PharMolix/UniProtQA huggingface dataset:
Protein: FEN1_THAPS
Sequence: MGIKGLAKLLSDEAPLSLKEVPLSHLHGRKLAIDASMAIYQFLIAVRSGGPGGQNAAMMLTNADGETTSHIQGIFNRTIRFISEGIRPVYVFDGKPPQFKSGELLKRREKRLKAEQALKAAEESGNIEEQDKQSKRLVRAGTKENEDCIKLLTLMGVPVIRAPCEAEAQAAALARSGKVYAAATEDMDALTFRSPVMVRKMTFANASKSDVQQIFYDKAIEGLEITHDQFVDLCILLGCDYCDTIKGIGPKTALKLIREHKNIETILKHLNREKYVVPDIYVEARRLFNHHEVLPDNEIELKWTECQPEPLKSFLVDEMGFNPDRVQASIEKLQKAFKASAKPQSRMDSFFKVKANPEGDKKKAEKRKAELAASRGKGKKGKGGGGFKKK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: RIBB_ECOK1
Sequence: MNQTLLSSFGTPFERVENALAALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMALTIRHGSGIVCLCITDDRRKQLDLPMMVENNTSAYGTGFTVTIEAAEGVTTGVSAADRITTVRAAIADGAKPSDLNRPGHVFPLRAQAGGVLTRGGHTEATIDLMTLAGFKPAGVLCELTNDDGTMARAPECIEFANKHNMALVTIEDLVAYRQAHERKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: TCAF1_PONAB
Sequence: MATPSAAFEALMNGVTSWDVPEDAVPCELLLIGEASFPVMVNDMGQVLIATSSYGRGRLVVVSHEDYLVEAQLTPFLLNAVGWLCSSPGAPIGVHPSLAPLAKILEGSGVDAKVEPEVKDSLGVYCIDAYNETMTEKLVKFMKRGGGLLIGGQAWDWANQGEDERVLFTFPGNLVTSVAGIYFTDNKGDTSFFKVSKKMPKIPVLVSCEDDLSEDREELLHGISELDISNSDCFPSQLLVHGALAFPLGLDSYHGCVIAAARYGRGRVVVTGHKVLFTVGKLGPFLLNAVRWLDGGRRGKVVVQTELRTLSGLLAVGGIDTSIEPNLTSDASVYCFEPVSEVGVKELQEFVAEGGGLFVGAQAWWWAFKNPGVSPLARFPGNLLLNPFGISITSQSLNPGPFRTPKAGIRTYHFRSTLAEFQVIMGRKRGNVEKGWLAKLGPDGAAFLQIPAEEIPAYMSVHRLLRKLLSRYRLPVATRENPVINDCCRGAMLSLATGLAHSGSDLSLLVPEIEDMYSSPYLRPSESPITVEVNCTNPGTRYCWMSTGLYIPGRQIIEVSLPEAAASADLKIQIGCHTDDLTRASKLFRGPLVINRCCLDKPTKSITCLWGGLLYIIVPQNSKLGSVPVTVKGAVHAPYYKLGETTLEEWKRHIQENPGPWGELATDNIILTVPTANLRTLENPEPLLRLWDEVMQAVARLGAEPFPLRLPQRIVADVQISVGWMHAGYPIMCHLESVQELINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCNLWCVYVHETVLGIPRSRANIALWPPVREKRVRIYLSKGPNVKNWNAWTALETYLQLQEAFGWEPFIRLFTEYRNQTNLPTDNVDKMNLWVKMFSHQVQKNLAPFFEAWAWPIQKEVTTSLAYLPEWKENIMKLYLLTQMPH
What is the function of this protein?
Positively regulates the plasma membrane cation channel TRPM8 activity.  Involved in the recruitment of TRPM8 to the cell surface.  Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.
What are the official names of this protein?
TRPM8 channel-associated factor 1, TRP channel-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the TCAF family.
What are the subcellular locations of this protein?
Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane.
Protein: DAPA_SHEFN
Sequence: MINGSIVALITPMNSDGTVDYASLERLVEFHIEQGTDAIVAVGTTGESATLPMTEHAAVVCQTVKFASGRIPVIGGNGANATAEAIELTKSMQKSGVVAMLGVTPYYNKPTPKGLIAHYTAVAASTDIPQILYNVPGRTAVDMKPETVAELSSVSNIIGVKEATGDLSRVARLRELCGEDFLLYSGDDATAREFLLLGGNGVISVANNIVPHAFKAMCDAALAKNAQLAETIDQPLTGIYRSLFCEANPIPVKWAVHRMGLIANGHIRLPLTELSEQFHGLLIETMKQAHIEVK
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOC31_MAIZE
Sequence: MGGRREAIERELKKLRAEREELDGRIRLLESQLEAGPAGFNGAAAGKGVGDDACGGSGACQSRVGNEFAPDGSLPADMIYRYSRHLLLPDFGVEGQRKLSQSSILVVGAGGLGSPLALYLAACGVGRLGIVDGDDVELNNLHRQIIHKEAYVGQSKVKSAADACREINSSIKVVEYHHTLKPCNALEVARKYDIVVDATDNLPTRYMISDCCVLLNKPLVSGAALGLEGQLTVYHHNGSPCYRCLFPTPPPVAACQRCSDSGVLGVVPGVIGCLQALEAIKVATGVGEPLCGRMLLFDALSARIRVVKLRGSSPDCTHCGENSVFTEEDFQKFDYESFTQSPMSDKAAPSVNVLPESARITCREYKKLADDGEPHLLLDVRPAHHFQIASISPSHNIPLSMLEEKLPALEASLKEAGEGSALVVLCRRGNDSQRAVQLLREKGFTSAKDIIGGLQAWGRDVDPDFPVY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Also essential during biosynthesis of the molybdenum cofactor.  Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A.  Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase MOCS3-1, Molybdenum cofactor synthesis protein 3-1.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MARC1_HUMAN
Sequence: MGAAGSSALARFVLLAQSRPGWLGVAALGLTAVALGAVAWRRAWPTRRRRLLQQVGTVAQLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVINQEGNMVTARQEPRLVLISLTCDGDTLTLSAAYTKDLLLPIKTPTTNAVHKCRVHGLEIEGRDCGEATAQWITSFLKSQPYRLVHFEPHMRPRRPHQIADLFRPKDQIAYSDTSPFLILSEASLADLNSRLEKKVKATNFRPNIVISGCDVYAEDSWDELLIGDVELKRVMACSRCILTTVDPDTGVMSRKEPLETLKSYRQCDPSERKLYGKSPLFGQYFVLENPGTIKVGDPVYLLGQ
What is the function of this protein?
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129).  As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771).  May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045).  Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045, PubMed:19053771).
What are the official names of this protein?
Mitochondrial amidoxime-reducing component 1, mARC1, Molybdenum cofactor sulfurase C-terminal domain-containing protein 1, MOSC domain-containing protein 1, Moco sulfurase C-terminal domain-containing protein 1.
Protein: SYV_DEHM1
Sequence: MAQCSGLPEMAKAYEAAEVEKKWYQYWMEKGYFKPNPDSDKKPFVIIMPPPNVTGELHLGHALTATLEDIMIRWHRMLGEPALWLPGADHAGIAAQVVVERMLAKQGKTRQELGRELFLEKMWEWVNPCRERIRHQHMRLGASCDWDRETFTLDPGPVKAVREIFTNLYQKGLIYRGERIINWCPRCATAVSDLEVDHKDLAGHIWHLRYPLEDGSGFVTVATTRPETMLGDTAVAVHPDDARYTGMVGKNVLLPIMNRRIPVIADEAVDMAFGTGAVKVTPAHDPNDFEMGLRHSLPMITIQNRDTTMNENAGPCSGMTAKACREYVVSELKSLGLLLKIEDYTHSVGHCQRCSAVIEPMVSKQWFVKMEPLAKPALEAVNSGRIQILPERFTKVYQNWMENIRDWCISRQLWWGHRIPVWYCPCGEMIVSKEDPTACPKCGSTKLEQDPDVLDTWFSSGLWPHSTLGWPDQTEDLKRFYPGSVLETAYDIIFFWVARMIVMGIEDMKEVPFRTVYLHGLIRDDKGEKMSKTKGNVIDPLKVIDQYGTDALRFAVTFGTSPGNDSKLGQTKLEAARNFVNKLWNASRFVIMNLGEEKELLPEAGLPLEDRWILSRMNRVTADVIRLMEEFQFGEAQRVLQDFVWGEFCDWYIELAKVRLRDEASVSPRPVLVKVLSTILRLLHPYMPFITEELWSYLRPYLPKSLGETDIIVAPFPQADETCFDEQAESIMGSLVEVVRSLRNLRAEHNVEISRYIQANIYAGDMAEVLSNYLGAVETLSRSRPVNILPGHYSGASTATEVVLVLNGIEVVVPMSTMVDLEAEAKRVEAEIAELETQIERLSARLSDTQFLAKAPQAVVDKERTKLEGYIEKVSRLKAV
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNK8_YEAST
Sequence: MAIENIYIARHGYRSNWLPKGPYPPPPTGIDNDVPLSEHGVEQAHELANYISKLDVKPEMIFSSPFYRCLETSKPTVEALKIPLYVDRGVGEWYKPDRPIIPEPATHEVMSKFFPSMISPDWEPSIIPSNKGETEEDIFERCHKFWPVFIDRVERKFPNVKTIMIVTHAATKSALGMNLLKFSSAKEPIDNKGTFIRNGSCAIDKFELVKGENESIPFEEREWKLTMNGNTSFLTNGEEMNWTFMNAFEAGSDADIKARRAAESGKLKME
What are the official names of this protein?
Uncharacterized protein YNL108C.
What is the protein family that this protein belongs to?
To yeast YOR110w.
Protein: YOKB_BACSU
Sequence: MNIRFSMLVCVSFIFFTGGCAESSANSNDGSKNKNESKEESSEEGVKENDNKLADTPNMDDCIEVYGKEECEQITEYYKSEEGQKELDASETDKYSAKSQTSTTHKDIYEKVSWLVKEMFGVPERTIPADYEKSLVEKRDDGLYYIQSSYEIKGTGNQADTYYEFEMLMDNKYNLIDAYFPGSTGRYSRPMVYDKLKNMEIPEVKKVSPEEEKREEKKREETMKSIYGEEHIKDNK
What are the official names of this protein?
SPbeta prophage-derived uncharacterized lipoprotein YokB.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GCP2_CAEEL
Sequence: MPYVGVGAQTVSTSLTGAPMVKAYIAIAASLIFVFCIAALGVHHSERKFNKFNKVSIDDIHKSDAGVIQDNIKTENIKKYLRIFTKDPHVAGTEANKKVAYEIANAWSEAGLEDVHTLPYEVLLSYPDFENPNSVIIKSSAGKEVFKSKGVSPVIIPDEQSGKYAGHQWLAYAGNGSASADVVYINHGTANDFKNLKLMGVDIKGKIALMRYGHGFRGDKIHKAQQAGAIGAILFSDTQDVAQDGVESENVYPKKIWMPNEGVQRGSLMHGDGDALSPYYPSKKELFKGRTIEEAKEDGVLPSIPVLPVSYTTGYEILKRLSGRPAPSDWQGFVGGNLTYKLGPGFVNGEKLSINVHSELRTKRIRNVIGYIRGSEEPDSYIMLGNHFDAWVYGSIDPNSGTAVLAEVARAMMQTINETSWKPARTIVFNAWDAEEFGLIGSTEFVEEFVNILQKRAVVYINMDCIQGNISLHVDTVPILEHAVIEASKQVENPSKRERSRGRKTLYDTWMKVFPDKKAGVPKIRVPGGGSDHAPFLNFAGVPVINFTFKNYTTWDTYPLYHTMYETPFSNIHLLDTDNLSVHKAIGQYWAELAKTFADDVILPMNTTHFASVMLKTYLPQLKTTISGINVSRSDFEDIRTQYALLSKSAQDLLTMSKKFQETIHFTQHSFSQNPYDPKHVNAVNERLKSTERCFINPRGVSMHNPSARHVLFSVSDSDSYSSSLMAGVQNAINSYDLNPTKKGLREIINQISIVQYSVICVVNTLRDVI
What are the official names of this protein?
Glutamate carboxypeptidase 2 homolog, Glutamate carboxypeptidase II homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: Y2160_ARCFU
Sequence: MVKSCSVGWGAKVAAVFAALYTSILGLAVLIPHANSAIEVFSAVMAAGLGILIALLAVPFISEITDKTETLEVEVIGEVVVEDSLSFGGANAGLKSERIFVADKGLVIDGYLFEWQKIKFEIEKDEIILRLPSGRRLPIPYSEELAEMLRKSKTSYFIDTK
What are the official names of this protein?
Uncharacterized protein AF_2160.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CO2FA_CONCE
Sequence: MEKLTFLILVATVLLTIHVLVQSVGDKHLKRRPKQYATKHLSALMRGHRQCTQQGYGCDETEECCSNLSCKCSGSPLCTSSYCRP
What are the official names of this protein?
Conotoxin Cap15a.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LRC55_HUMAN
Sequence: MGDTWAQLPWPGPPHPAMLLISLLLAAGLMHSDAGTSCPVLCTCRNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCCHRWSKASEEEEI
What is the function of this protein?
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha).  Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.
What are the official names of this protein?
Leucine-rich repeat-containing protein 55, BK channel auxiliary gamma subunit LRRC55.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DPTL_DIPMA
Sequence: MKTIIAAIFLGILMHAFAKECTLMAAASNFNSDKYFDVPHVYVTHSKNGPKEKVCREYNTTKNSDKTTSTTVVTLKTGGTQSIVLSCNNSPKSGVKGQYFMDCQVPGGTGGINIQLESSIIATDNKNYALVHFCPITGRGVTEDIVVLQTNKDNVDPGVTSAIKNYGWSLENWKSRKDAGCQ
What is the function of this protein?
Inhibits platelet aggregation, vasoconstriction, and angiogenesis through binding to distinct eicosanoids involved in inflammation (acts as a scavenger), and has a role in inhibiting host innate immunity by impairing platelet-assisted formation of neutrophil extracellular traps (NETs) (PubMed:20889972, PubMed:26110417).  Inhibits platelet aggregation by collagen (IC(50)=30 nM), thromboxane A2 mimetic (TXA2 mimetic), or arachidonic acid (AA) without affecting aggregation induced by ADP, convulxin (GP6 agonist), PMA, and ristocetin (vWF-dependent platelet agglutinator) (PubMed:20889972, PubMed:26110417).  Binds with high affinity to TXA2, TXB2, prostaglandine H2 mimetic (PGH2 mimetic), PGD2, PGJ2, and PGF2alpha (PubMed:20889972).  Also interacts with 15(S)-hydroxyeicosatetraenoic acid (HETE), being the first calycin/lipocalin described to date to bind to a derivative of 15-lipoxygenase (PubMed:20889972).  Binding is not observed to other prostaglandins, leukotrienes, HETEs, lipids, and biogenic amines (PubMed:20889972).  It prevents contraction of rat uterus stimulated by PGF2alpha and induces relaxation of aorta previously contracted with TXA2 mimetic (PubMed:20889972).  In addition, it inhibits angiogenesis mediated by 15(S)-HETE and does not enhance inhibition of collagen-induced platelet aggregation by SQ29548 (TXA2 antagonist) and indomethacin (PubMed:20889972).  Also impairs platelet-assisted formation of neutrophil extracellular traps (NETs) (PubMed:26110417).  NETs are web-like structures of DNA and proteins that play an important role in killing of pathogens (PubMed:26110417).  In addition, NETs are implicated in thrombus formation (PubMed:26110417).  In vivo, this protein exhibits antithrombotic activity in two distinct mice models that are highly dependent on platelets (PubMed:26110417).  It is noteworthy that it inhibits thrombosis without promoting excessive bleeding (PubMed:26110417).
What are the official names of this protein?
Dipetalodipin, DPTL, Salivary lipocalin.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Triabin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEMA_CVMS
Sequence: MGCMCIAMAPRTLLLLIGCQLVFGFNEPLNIVSHLNDDWFLFGDSRSDCTYVENNGHPKLDWLDLDPKLCNSGRISAKSGNSLFRSFHFIDFYNYSGEGDQVIFYEGVNFSPSHGFKCLAYGDNKRWMGNKARFYARVYEKMAQYRSLSFVNVSYAYGGNAKPTSICKDKTLTLNNPTFISKESNYVDYYYESEANFTLQGCDEFIVPLCVFNGHSKGSSSDPANKYYTDSQSYYNMDTGVLYGFNSTLDVGNTVQNPGLDLTCRYLALTPGNYKAVSLEYLLSLPSKAICLRKPKSFMPVQVVDSRWNSTRQSDNMTAVACQLPYCFFRNTSADYSGGTHDVHHGDFHFRQLLSGLLYNVSCIAQQGAFVYNNVSSSWPAYGYGHCPTAANIGYMAPVCIYDPLPVILLGVLLGIAVLIIVFLMFYFMTDSGVRLHEA
What is the function of this protein?
Structural protein that makes short spikes at the surface of the virus.  Contains receptor binding and receptor-destroying activities.  Mediates de-O-acetylation of N-acetyl-4-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells.  This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell.  May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one.  May become a target for both the humoral and the cellular branches of the immune system.
What are the official names of this protein?
Hemagglutinin-esterase, HE protein, E3 glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface.
Protein: ERCC8_BOVIN
Sequence: MLGFLSARQAGLEDPLRLRRAESTRRVLGLELNKDRDVERIHCSGVNTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQPYYTCKAVCSVGRSHPDVHKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQIADVFNFEETVYSHHMSPVATKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYEYILATASADSRAKLWDVRRASGCLITLDQHNGKKSQAAESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVYNDSRKGLKFTVSSGCSSEFVFVPYGSTIAVYTIYSGEQITMLKGHYKSVDCCVFQSNFQELYSGSRDCNILAWVPSLCESVPDDDDETSTRSQLNPAFEDAWSSSDEEG
What is the function of this protein?
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair (By similarity).  The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair (By similarity).  It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (By similarity).  Plays a role in DNA single-strand and double-strand breaks (DSSBs) repair; involved in repair of DSSBs by non-homologous end joining (NHEJ) (By similarity).
What are the official names of this protein?
DNA excision repair protein ERCC-8.
What are the subcellular locations of this protein?
Nucleus. Nucleus matrix. Note=UV-induced translocation to the nuclear matrix is dependent on ERCC6.
Protein: RP54_RHOCB
Sequence: MELAQTLSQRQTMQMAGQMLHSLAILGMSSQDLSEHLTEQATSNPFLTYRAPPAFIARGGEDFDAVAAVAAHKPSLMAHVVDQIEMAFTETPDRLLALRFAEALEPSGWLGQSLDSIALAAGVSLSRAESMLAVLQGFEPTGLFARDLSDCLILQAREADILTWEVETLIRNIRLIAENRLSDLADLCDCDIGDIPEIIKQIRHLNPKPGLAFDHQPTPVFPPDLIAVRGAEGWTVELNRATSPTITVREDRFADGTADAKARAERRKALAEARALAQALERRGDTLLRTAAVLVARQSAFLDKGPAHLVPLTLEDVASELGLHASTISRAVSGRMIQTQTRALPLRAFFSRAVSTQGGGEAVSRDSALDFVQRTVGGEDPQNPLSDDAIVTLAERAGLRIARRTVAKYRSTLGLASSYERRRAAAAR
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is responsible for the expression of the nitrogen fixation genes.  The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein nifA for the expression of the nitrogen fixation proteins.
What are the official names of this protein?
RNA polymerase sigma-54 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: DNAK_THEM4
Sequence: MSSKKEYVVGIDLGTTNSVIAWMKPDSSVEVIPNAEGARTTPSIVAFSKSGEILVGEPAKRQLILNSDRTIKSIKRKMGTDYKVKIDDKEYSPQEISAFILKKLKKDAEEYLGGEIKRAVITCPAYFNDAQRQATKEAGIIAGFDVLRIINEPTAAALAYGLDRKGKEEKVLVYDLGGGTFDVSILEIGDGVIQVIATSGNNHLGGDDFDQRIIDWLAEEFKKQHGVDLKEDKQALQRLRDAAEKAKIELSSKLETDISLPYITATAEGPLHLEMRLTRSMFESLTRDLVEMTRKPIEQALSDAKLKPEDIDEIILVGGMTRVPMIQNFIKEIFGKEPNKRVNPDEAVAMGAAIQAAILAGEEGAQGKDIVLVDVTPLTLGIEVKGGLFEPIIPRNSTIPIKKSKVFTTAEDGQTEVEIRVFQGERPIAADNILLGSFRLVGIPPAPRGVPQIEVTFDIDSDGIVHVSAKDLGTGKEQTMVVSGRHKLSEEDINKIIEDAKKYEEQDKRRKEEVELKNKADDLAYYIDKSLKEYGDKIPQDEKQKLETLVNDLRDAINKNDIARIKMLFDELEREKTKIGEYIYKQNQGNQQAENQ
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: COMT_RAT
Sequence: MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDKS
What is the function of this protein?
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.  Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
What are the official names of this protein?
Catechol O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
What are the subcellular locations of this protein?
[Isoform Soluble]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform Membrane-bound]: Cell membrane; Single-pass type II membrane protein; Extracellular side.
Protein: HXT17_YEAST
Sequence: MQSSTESDRDIQDGPDADIHVAPPVEKEWSDGFDDNEVINGDNVEPPKRGLIGYLVIYLLCYPISFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYYLSNVRMGLLVAMFSIGCAIGGLIFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYDNTAQWRVPLGLCFLWTLIIIIGMLLVPESPRYLIECERHEEARASIAKINKVSPEDPWVLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYGTTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAAGMMACMVIFASIGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSRAMSISTACNWLWQFLIGFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFFLPETIGLSLEEIQLLYEEGIKPWKSASWVPPSRRGIPSEESKTEKKDWKKFLKFSKGSD
What is the function of this protein?
Probable glucose transporter.
What are the official names of this protein?
Hexose transporter HXT17.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RNH_NEOSM
Sequence: MEEYVIYTDGACLGNPGPGGWAAVIIQRGTNEKIISGREADSTNNKMELLAVIKALESFEQKGKRVTVYTDSTYVYKGITAWIESWMKNKWRNSSGGAVKNKEMWVRLHGIAAAHTVRWLWVKAHNGDHYNEIVDRVARKEAASFTNCEPE
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPH_RHOPB
Sequence: MRPSRRAPDELRAVSLERGVVKYAEGSCMVKFGDTHVLVTATLEDRLPPWLKGQGRGWVTAEYGMLPRATLERTRREASAGKQNGRTVEIQRLIGRSLRATVDLQALGERQITVDCDVIQADGGTRTASITGAWVALADCIGWMKTRNMFKGTAPVLRDNVAAISCGIYNGTPVLDLDYAEDSEADTDANFVMTGDGRIIEVQGTAEKTPFSQDEFLALMALAKKGVARLVDLQKMAVA
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.