PharMolix/UniProtQA huggingface dataset:
Protein: LPP2_SALTI
Sequence: MNRTNKLILGAVVLGSTLLAGCSSNAKIDQLSSDVQTLSAKVDQLSNDVNAMRSDVQAAKDDAARANQRLDNKVFRICK
What is the function of this protein?
A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes.  The only protein known to be covalently linked to the peptidoglycan network (PGN).  Also non-covalently binds the PGN.  The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
What are the official names of this protein?
Major outer membrane lipoprotein Lpp 2, Braun lipoprotein 2, BLP 2, Murein lipoprotein 2.
What is the protein family that this protein belongs to?
Belongs to the Lpp family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side. Secreted, cell wall; Peptidoglycan-anchor. Note=Attached via its lipidated N- terminus to the inner leaflet of the outer membrane. Attached to the peptidoglycan network (PGN) via its C-terminus.
Protein: MYB97_ARATH
Sequence: MIVYGGGASEDGEGGGVVLKKGPWTVAEDETLAAYVREYGEGNWNSVQKKTWLARCGKSCRLRWANHLRPNLRKGSFTPEEERLIIQLHSQLGNKWARMAAQLPGRTDNEIKNYWNTRLKRFQRQGLPLYPPEYSQNNHQQQMYPQQPSSPLPSQTPASSFTFPLLQPPSLCPKRCYNTAFSPKASYISSPTNFLVSSPTFLHTHSSLSSYQSTNPVYSMKHELSSNQIPYSASLGVYQVSKFSDNGDCNQNLNTGLHTNTCQLLEDLMEEAEALADSFRAPKRRQIMAALEDNNNNNNFFSGGFGHRVSSNSLCSLQGLTPKEDESLQMNTMQDEDITKLLDWGSESEEISNGQSSVITTENNLVLDDHQFAFLFPVDDDTNNLPGIC
What is the function of this protein?
Transcription activator (PubMed:24278028).  Binds to 5'-CAACTGTC-3' and/or 5'-TAACAAA-3' motif in target gene promoter to promote their expression (By similarity).  Together with MYB101 and MYB120, functions as a male factor that controls pollen tube-synergid interaction in fertilization.  Required for pollen tube growth arrest and sperm cell release in the female gametophyte, probably via the regulation of pollen tube-specific gene expression (PubMed:24278028, PubMed:23791732).
What are the official names of this protein?
Transcription factor MYB97, Myb-related protein 97, AtMYB97.
What are the subcellular locations of this protein?
Nucleus. Note=Detected in the vegetative nucleus of pollen tubes.
Protein: RS8_METST
Sequence: MSLMDPLADALTNIRNNELQGNDSCVIKPASKLIGHVLSTMQKENYIGNFELVDDGKAGIFNVELVGNINKCGVIKPRHAVKNTEFEDYEKRYLPAKNFGILIVTTPQGVMTHHEAKEAGIGGRLLVYVY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PP119_ARATH
Sequence: MRFILRHLHSLGVINKFDSFLLHFHTKSLKSNHTLKQYLESGEPIKALLDFRHRFRQSPSFVDSFSVLFAIKVSSAQKASSLDGRQIHALVRKLGFNAVIQIQTSLVGFYSSVGDVDYARQVFDETPEKQNIVLWTAMISAYTENENSVEAIELFKRMEAEKIELDGVIVTVALSACADLGAVQMGEEIYSRSIKRKRRLAMDLTLRNSLLNMYVKSGETEKARKLFDESMRKDVTTYTSMIFGYALNGQAQESLELFKKMKTIDQSQDTVITPNDVTFIGVLMACSHSGLVEEGKRHFKSMIMDYNLKPREAHFGCMVDLFCRSGHLKDAHEFINQMPIKPNTVIWRTLLGACSLHGNVELGEEVQRRIFELDRDHVGDYVALSNIYASKGMWDEKSKMRDRVRKRRMPGKSWIELGSIINEFVSGPDNNDEQLMMGEISEVLRCLVSCMTSFDCVIGKKM
What are the official names of this protein?
Putative pentatricopeptide repeat-containing protein At1g74400.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-E subfamily.
Protein: NSA2_ASPCL
Sequence: MRLPQLKIQYIERWQKQHGKRLDHDERVRKRQAREGHKQSQDAQNLRGLRAKLYQQKRHKEKIQMRKRIKAQEEKNVKSSAPDEPSKTPLPQYLLDRSQATNAKALSSAIKDKRAEKAAKFAVPLPKVKGISEEEMFKVVDTGKKTHKKSWKRMITKPTFVGSDFTRRPVKYERFIRPMGLRYKKANVTHPELGVTVQLPILGVKKNPQNPLYTQLGVLTKGTIIEVNVSELGIVTTSGKVVWGKYAQITNTPENDGTVNAVLLV
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit.  May play a part in the quality control of pre-60S particles (By similarity).
What are the official names of this protein?
Ribosome biogenesis protein nsa2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TONSL_MOUSE
Sequence: MTLEQELRQLSKAKTRAQRNGQLREEAAYCHQLGELLASHGRFKDALEEHQQELHLLESVQDTLGCAVAHRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDIYDHCQSRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCESLQQTALCNNYFKKSIFLAEQNHLYEDLFRARYNLGAIHWRGGQHSQAMRCLEGARECARAMKMRFMESECCVLVSQVLQDLGDFLAAKRALKKAYRLGSQKPNQRVTVCQSLKYVLAVIQLQQQLEEAEGNDLQGAMAICEQLGDLFSKAGDFPKAAEAYQKQLHLAELLNRPDLELAVIHVSLATTLGDMKDHRKAVHHYEEELRLRKGNALEEAKTWFNIALSREEAGDAYELLAPCFQKAFCCAQQAQRFQLQRQILQHLYTVQLKLQPQEARDTEIRLQELSMAKDTEEEEEEEEEEEEEASEAPETSELELSESEDDADGLSQQLEEDEELQGCVGRRKVNKWNRRNDMGETLLHRACIEGQLRRVQDLVKQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCDGITPLHDALNCGHFEVAELLIERGASVTLRTRKGLSPLETLQQWVKLYFRDLDLETRQKAATMEERLQMASSGQASRSSPALQTIPSNHLFDPETSPPSSPCPEPSSYTPRPPEASPAPAKVFLEETVSAVSRPRKTRHRPTSSSSSSEDEDNPSPCRPSQKRLRHTTQQGEVKIPDPPKSRETATSSACRAAYQAAIRGVGSAQSRRLVPSLPRGSEEVPAPKTALIPEEEYLAGEWLEVDTPLTRSGRPSTSVSDYERCPARPRTRVKQSRLTSLDGWCARTQAGDGSLNAEPAENPSVPRTSGPNKENYAAGQPLLLVQPPPIRVRVQIQDNLFLIPVPQSDIRPVAWLTEQAAQRYFQTCGLLPRLTLRKDGALLAPQDPIPDVLQSNDEVLAEVTSWDLPPLKDRYRRACLSLGQGEHQQVLHAMDHQSSSPSFSACSLALCQAQLTPLLRALKLHTALRELRLAGNRLGDACATELLATLGTTPNLVLLDLSSNHLGQEGLRQLVEGSSGQAALQNLEELDLSMNPLGDGCGQALASLLRACPMLSTLRLQACGFSSSFFLSHQAALGGAFQDAVHLKTLSLSYNLLGAPALARVLQTLPACTLKRLDLSSVAASKSNSGIIEPVIKYLTKEGCALAHLTLSANCLGDKAVRELSRCLPCCPSLTSLDLSANPEVSCASLEELLSALQERSQGLSFLGLSGCSIQGPLNSDLWDKIFVQLQELQLCTKDLSTKDRDSVCQRLPEGACTMDQSSKLFFKCL
What is the function of this protein?
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks.  The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication.  It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs.  Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination.  Within the complex, TONSL acts as histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones.  Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3. 1.
What are the official names of this protein?
Tonsoku-like protein, Inhibitor of kappa B-related protein, I-kappa-B-related protein, IkappaBR, NF-kappa-B inhibitor-like protein 2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2.
What is the protein family that this protein belongs to?
Belongs to the Tonsoku family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks. Recruited to stalled or collapsed replication forks following histone replacement by histone chaperones ASF1A and the CAF-1 complex: TONSL acts as histone reader that recognizes and binds newly synthesized histones.
Protein: MNHA1_STAA2
Sequence: MSLLHIAVILPLIFALIIPILYRFFKRIHLGWFVLPVPIVIFIYMLTLIKTTMSGNTVMKTLNWMPHFGMNFDLYLDGLGLLFSLLISGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNVIILYLFWELTSFSSFLLISFWRERQASIYGAQKSLIITVFGGLSLLGGIILLAIPTQSFSIQYMIQHASEIQNSPFFIFAMILIMIGAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARMTPIFAASQGWVWTVTLVGLITLFWASLNATKQQDLKGILAFSTVSQLGMIMAMLGIGAISYHYQGDDSKIYAAAFTAAIFHLINHATFKGALFMITGAVDHSTGTRDVKKLGGLLTIMPISFTITVITALSMAGVPPFNGFLSKESFLETTFTASQANLFSVDTLGYLFPIIGIVGSVFTFVYSIKFIMHIFFGQYKPEQLPKKAHEVSILMLLSPAILATLVIVLGLFPGILTNSIIEPATSSINHTVIDDVEFHMFHGLTPAFLSTLVIYILGILLIVTFSYWVKLLQRQPGKLTFNYWYNRSANVIPNYSEKMTNSYVTDYSRNNLVIIFGALILLTFVTIFSVPFNINFKDVSPIRIFEVCIVILLLSAAFLILFAKSRLFSIIMLSAVGYAVSVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKRSFQLTNALIAGGVGLSVIIIGLIAYGNRHFESISKFYQEHVYDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLAVYTMIKLRKKRQTQGNEVKNHE
What is the function of this protein?
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
What are the official names of this protein?
Na(+)/H(+) antiporter subunit A1, Mnh complex subunit A1.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUOB_BACMK
Sequence: MVINFEELHPQERAELERNIFFSTLEQLKGWARSNSLWPMTFGLACCAIEMMGVGSSHYDLDRFGSFFRTSPRQSDVMIVSGTVTKKMAPIVRRLYDQMPEPKWVIAMGSCATAGGPYVNSYAVVKGVDQIVPVDVYIPGCPPNPAALIYGINKLKEKIRYEARTGKQVTNK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL4_RHOP5
Sequence: MELKVTTLEGKDAGSVQLSDEIFGLDPRSDIIQRCVIWQLAKRQAGTHKAKGRAEIWRTGKKMYKQKGTGGARHGSQRVPQFRGGGRAFGPVVRSHAIDLPKKVRAMALKHALSAKAKDGGLIVIDQATLDSAKTKALVGHFAGLGLTSALIIDGAELNNGFAVAARNIPNIDVLPIQGINVYDILRRQKLVLTKAAVDALEARFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: Y202_BURCM
Sequence: MCHAAPAAPASGRGLPHGGGNFSGAAGSRSVGATFEQRARQFLERRGLAFVAANVTMRGGELDLVMRTPDGTLVFVEVRARRSTRHGGAAASVGWRKRRRLVKAALHFWVRHGKGAACRFDVVAFEAGRLEWLHDAFRADDV
What are the official names of this protein?
UPF0102 protein Bamb_0202.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: OMP19_BRUAB
Sequence: MGISKASLLSLAAAGIVLAGCQSSRLGNLDNVSPPPPPAPVNAVPAGTVQKGNLDSPTQFPNAPSTDMSAQSGTQVASLPPASAPDLTPGAVAGVWNASLGGQSCKIATPQTKYGQGYRAGPLRCPGELANLASWAVNGKQLVLYDANGGTVASLYSSGQGRFDGQTTGGQAVTLSR
What are the official names of this protein?
Outer membrane lipoprotein omp19, 18 kDa immunoreactive antigen, 19 kDa OMP, Minor outer membrane protein omp19.
What is the protein family that this protein belongs to?
Belongs to the rhizobiaceae omp19 lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: CSK2A_ENCCU
Sequence: MVVVTVARSNADVNEKKDERYWNYECYTITTGSIEKYQIYQRMGRGKYSEVFEGRKDREKIVIKALKPVRKAKICREVLILRNLSHKNIIKLMDVVVDPESQIYSLIFEYIEHEDYAKIFEKLCYKDIVEYSRQILSALSYCHSMGIIHRDIKPQNMVINQARRELKIIDWGLAEFYHPKKEYSVRVASRYYKGPELLVDYPYYDYSLDIWSFGCVLAELVFKKRPFFHGESNSDQLVKIARILGYTHLKKYVRKYKMAPLNPKYEGVGERVLLSSFTPPGKTGLYTNAIDLLEKILIYDHQDRPTADECLRHPLFESR
What is the function of this protein?
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
What are the official names of this protein?
Probable casein kinase II subunit alpha homolog, CK II subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Protein: LUXS_STRA5
Sequence: MTKEVVVESFELDHTIVKAPYVRLISEEVGPVGDIITNFDIRLIQPNENAIDTAGLHTIEHLLAKLIRQRINGLIDCSPFGCRTGFHMIMWGKQDATEIAKVIKSSLEAIAGGVTWEDVPGTTIESCGNYKDHSLHSAQEWAKLILSQGISDNAFERHIV
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: VF364_ASFK5
Sequence: MYFLVADHREHHVIPFLKTDLQHIYQNPTQKKQIPLEIKQLFTGDYLICKSPSTILACIERKTYKDFAASLKDGRYKNRQKMLSLREQTKCQLYFFVEGPAFPNPQKKINHVAYASIITAMTHLMVRDHIFVIQTKNEAHSSQKLVQLFYAFSKEMVCVVPTSLTPTDEELCIKLWSSLSGISGVIGKILANTCSVAHLVSGQLPPQNIDQLKTPSNRPFPKKVKRMLISISKGNKELEIKLLSGVPNIGKKLAAEILKDHALLFFLNQPVECLANIQIAQKTRTIKLGMKRAEAIHYFLNWCGSARVTVDSQNITETSRPATIQATATQPAATQPLHEISNEALNEASNDASNEVTHTGHQTLFI
What is the function of this protein?
Plays a role in the inhibition of type I interferon signaling pathway.  Mechanistically, specifically interacts with 2',3'-cGAMP and cleaves it via its phosphodiesterase activity.  In turn, prevents 2',3'-cGAMP interaction with host ER-resident STING1 leading to inhibition of downstream signaling pathway and type I interferon production.
What are the official names of this protein?
ERCC4 domain-containing protein EP364R, pEP364R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus EP364R family.
Protein: MTND_LEPBL
Sequence: MATIVRQKGLAPIEETSEVKSFLKERGIDYDHWKVPYNAADLTDKEILADVEKEELLKKLDDRFETLKEKEGYQSRDLIVLHPNVSGLNDMLAKFDRVHYHTDEEVRYIVDGSGVFGFVLKGEKFLVHVVKDDFISVPRNTNHWFYLDDKKRIKAVRYFRDMSGWVPNYVEETNSLD
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: PNTAA_RHORU
Sequence: MKIAIPKERRPGEDRVAISPEVVKKLVGLGFEVIVEQGAGVGASITDDALTAAGATIASTAAQALSQADVVWKVQRPMTAEEGTDEVALIKEGAVLMCHLGALTNRPVVEALTKRKITAYAMELMPRISRAQSMDILSSQSNLAGYRAVIDGAYEFARAFPMMMTAAGTVPPARVLVFGVGVAGLQAIATAKRLGAVVMATDVRAATKEQVESLGGKFITVDDEAMKTAETAGGYAKEMGEEFRKKQAEAVLKELVKTDIAITTALIPGKPAPVLITEEMVTKMKPGSVIIDLAVEAGGNCPLSEPGKIVVKHGVKIVGHTNVPSRVAADASPLFAKNLLNFLTPHVDKDTKTLVMKLEDETVSGTCVTRDGAIVHPALTGQGA
What is the function of this protein?
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.
What are the official names of this protein?
NAD(P) transhydrogenase subunit alpha part 1, Nicotinamide nucleotide transhydrogenase subunit alpha 1, Proton-translocating transhydrogenase component 1, Pyridine nucleotide transhydrogenase subunit alpha 1, dI.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
Protein: AROD_ECOUT
Sequence: MKTVTVKDLVIGTGAPKIIVSLMAKDIASVKSEALAYREADFDILEWRVDHYADLSNVESVIAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLAGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: CALM_CHICK
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
What is the function of this protein?
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding.  Calcium-binding is required for the activation of calmodulin.  Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: GMPPA_PAPAN
Sequence: MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQPDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDFPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLTDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPRIRGNVYIHPTAKVAPSAVLGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPNDPNPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL
What is the function of this protein?
May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.
What are the official names of this protein?
Mannose-1-phosphate guanyltransferase alpha, GDP-mannose pyrophosphorylase A, GTP-mannose-1-phosphate guanylyltransferase alpha.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAPCB_RAT
Sequence: MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF
What is the function of this protein?
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs.  PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.  Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.  Phosphorylates GPKOW which regulates its ability to bind RNA.
What are the official names of this protein?
cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Membrane; Lipid-anchor. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
Protein: SUCC_RICPR
Sequence: MNIHEYQAKEILRKYGVPTSTGLVVTKTEKINETIDKLNTKVYVIKAQIHAGGRGKAGGVKVAKSKEEAKKVAHDMFGINLVTHQTGPQGQKVNRIYIESGCDILKEYYFSIVFDRSASCITFIASTEGGVDIEAVAEKMPEKIIKFAVDPATGLQDFHMRGIAYELGFKDNQAKQMKEIVKAVYNAFIETDATQIEINPLIINSYGNLLALDAKITFDDNGLFKHPNITAMRDHDEEDPLETRAANAGLSYVKMDGNIGCMVNGAGLAMATMDIIKLYGALPANFLDVGGGADRERVKEALKIILSDKEVKGILVNIFGGIMRCDIIAEGIIAAAKDIGIKVPLVVRLAGTNVEKGKEILSNSDLKIIPAHDLADAANKIVEAIR
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RNF12_XENTR
Sequence: MESADSAGKGSTEQSESQRQSQMDRLDREEAFYQFVNNLNEDDYRLMRDNNLLGTPGEITKEELLRRLQQIKEGPPQPSTEGTRGDPVSASGDPAEDSSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRTSGNPSMPSLEQSSEMPGAEDMEVSSQGENENEPEPVAPRVAQAEVTEEAPVQRGQRRARSRSPDQRRTRARTDRSRSPLHQAVEPPIRRAQHSSSQTVDASSTEEAEGSSRTRHHVSSQMQNSSSSNETEGSSRTRQHITARQQALGTEGQSQSQTQTQSQSQTQTQSQTQSQSTVHLSNPESRSSSQPPQTDSSSNAETTGTGQRPPTIVLDLQVRRVRPGDYRQRDSIANRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYNDNDTDPNNPTPVSPPAAVPGEAQNLVSPEPPAPIVEPPEPVAPVESEEGSNVSTSSARREGRNSRGGVTFEESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLSTRNFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLVAGNRESIV
What is the function of this protein?
Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner.  Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the formation of a ldb1-lhx1/lim1 complex.  Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF12, RING finger protein 12, RING-type E3 ubiquitin transferase RNF12.
What is the protein family that this protein belongs to?
Belongs to the RNF12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPD_JANSC
Sequence: MTDAPLSEAMKPIIFSASEGPLSRAQAEEAFNLMFEGLASPAQMGGLIMAIRARGESVAEYAAAAQVMRDRCVKVSAPDGAMDIVGTGGDGMGTLNISTATAFVVAGAGVPVAKHGNRNLSSKSGAADVLTQMGINVMVGAAVVEQSLKEAGIGFMMAPMHHPAVKHVMPIRQELGCKTIFNILGPLTNPAGAKRQLTGAFAIDLIYPMAETLKELGSEAAWLVHGSDGTDEISISGKTDVVELKDGALRSRVVHPEDAGLPVHPFRDILGGTPDENAQAFRDLLDGAQGAYRDAVLLNAAAALIVAGRVTELRDGVEIARESIDSGAAKRAVEAVARVTSTSTA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: DAPB_SYNS9
Sequence: MSSPIPVVVAGALGRMGAEVINAVVNAEDCQLVGAIDNTPGKEGTDVGLELGIKELEVAVTADFEGCLCAVSQSVRNSDQNAVLVDFTHPSVVFDHTRAAIAYGVHPVIGTTGLSPIQLNDLTEFSAKASIGGAVIPNFSVGMVLLQQAAAAAARFYDHAELTELHHNRKADAPSGTCIKTAELMEEVKQSFNPAEVDEHESLQGSRGGVRDSGLNLHSLRLPGLVAHQEVMFGAPGETYTLRHDTIDRSAYMPGVLLTIRKVGSLQQLVYGLERLI
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.