PharMolix/UniProtQA huggingface dataset:
Protein: RL21_ECOLI
Sequence: MYAVFQSGGKQHRVSEGQTVRLEKLDIATGETVEFAEVLMIANGEEVKIGVPFVDGGVIKAEVVAHGRGEKVKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21, Large ribosomal subunit protein bL21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: HEMO_PIG
Sequence: MARALGTVEAPWLLGLCCSLAIAHPLSLTAGPKHGAEGRNESKPDPDVTERCSDGWGFDASTLDEHGAMLFFKGPSVWAGQNWTRGLISERWKNAPSSVDAAFRRGHDRVFLIQGDKVWVYPPEKEKENPRSLQEEFPGVPSPLDAAVECHRGECQDEGVLFFQGTHTWFWDSTTKTTKERLWPAVGNCSSAMRWISRYYCFRGNQFLRFDPVTGHVDPKYPRDVRDYFMSCPGRGHAHRNATHRGDDRCSPDLVLTALLSDNHGATYAFRGTHYWRLDTSRDGWHSWPIDHQWSHGPSAVDAAFSWDDKLYLIQGTQVYIFLTKAGYTLVDNYPKQLEKELGSPHGISLDAVDATFVCPGTSRLHVMAGRKLWWLDLSLGAQGPWTELPWPHEKVDAALCTEKSLGPNSCSASGLGLYIVHGPHVYCYKDVEKLVSAKALPQPQSVNSLLGCHRSRGS
What is the function of this protein?
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
What are the official names of this protein?
Hemopexin, Hyaluronidase.
What is the protein family that this protein belongs to?
Belongs to the hemopexin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS18_BRUSU
Sequence: MVDINQIPTRRPFHRRRKTCPFSGANAPKIDYKDVKLLQRYISERGKIVPSRITAVSQKKQRELAKAIKRARFLGLLPYVVK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: F16PA_OLEA2
Sequence: MRQVTVTEHLLLHQTKSPAATGQFTALLYDLILAAKIISKSVNKAGLLDVLGGTGQVNVQGEHVQKLDEYANRVLIHRMERTGVLCAMASEENADLIRVPERFEAGDYILIFDPLDGSSNIDVNINVGTIFSILKRKPGASGSKDVTLGDVLQSGVEQVAAGYFLYGPSTMLVYSSGQGVHGFTLDPSVGEFLLSHPDIRYPEQGRIYSVNESYWHYWDEPTREVVSYFKGPDNPLGKPYSLRYVGSLVADFHRNLFYGGIFMYPMDYRLPEKPQGKLRLMCEASPLAFLAEQAGGRATDGTKRILDIVPGELHQRVPLFIGSAGDVDAVEAIYRRHS
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SGPL_ARATH
Sequence: MDSFSYSSMKSMLIQARGSLNSRLSEFEPLVLLLVPLVSLFLAQIIGSVFGVVHEKGLKACLIGFIMGLLKMIPGVQNYIDAEKQKVVDQLQSGSSSKKKNKTEVLPVKGLGVEVLEKMENEKRNDAIWQGKCSGTVYIGGAESEGHFSLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSKETASGGQICGNMTSGGTESIVLAVKSSRDYMKYKKGITRPEMIIPESGHSAYDKAAQYFKIKLWRVPVDKDFRADVKATRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLALSYGICFHVDLCLGGFVLPFARKLGYQIPPFDFSVQGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLQNTSKIMEASKRLEEGVREIHELFVIGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICITLQHVPVVDDFLRDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFMDSQY
What is the function of this protein?
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine.  May play a minor role in maintenance of sphingolipid metabolism during normal plant development and growth, but be required for maintaining sphingoid long chain bases (LCB) and their phosphorylated derivatives (LCB-P) levels when sphingolipid metabolism is perturbed.  May play a role in dehydration stress.
What are the official names of this protein?
Sphingosine-1-phosphate lyase, AtSPL1, S1PL, SP-lyase, SPL, Dihydrosphingosine phosphate lyase 1, AtDPL1, Sphingosine-1-phosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: ATPG_BACC1
Sequence: MASLRDIKAKINSTKKTSQITKAMEMVSASKLNRAEQNAKSFVPYMEKIQEVVASIAQGSKGINHPMLNARPVKRTGYIVITSDRGLAGGYNSNVLRTVSNVIRERHNMDSNQYSIIVLGRLGRDYLKRRGFNIIDEVVGLSDHPSFTDIKDLASRAIAMFADGAYDELYIYYNHYVSKISQEVTENKILPLTDVASDKPTTAYEFEPSEEEILKVLLPQYAESLVYGALLDGKASEHAARMTAMKSATDNAMEVIDSLTLSFNRARQAAITQEITEIVGGAAALE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DGCA_TREDE
Sequence: MKTTPNEKLLKKALHSCNNKKYADKILHQEKEIFDLKQLLQISKSLNSVLEFDRLIEAILYIVMAQLKTLGAAIFTKKSFDDNLFVLNRDHYGFDIIRDAQYSINVDHPLINFLDKSDSGCTPDEISKNIKTDKIVKDLFSLSPSFFVPLKAKNRMIGFLLLGEKMESSHQFTDYEKNIIENIASLAAIAINNSQLLEMTTTDIMTHLKLKHYFFTLLMEHLYTINSSGEKKETLSILMIDIDFFKNINDTYGHAAGDIVLEEVAKIIKSCTRNADTAARYGGEEFIVMLNNTSASAAMAVAERIRKSVEEKSIMYDGKKINVTISIGVSSYNFDLESAKSIVERADKALYESKQNGRNRVTLSKNNLPKA
What is the function of this protein?
Catalyzes the conversion of GTP to cyclic-di-GMP (c-di-GMP).  Shows activity under aerobic and anaerobic reaction conditions.
What are the official names of this protein?
Diguanylate cyclase A, DGC.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VIRG_RHIRD
Sequence: MIVHPSRENFSSAVNKGSDFRLKGEPLKHVLLVDDDVAMRHLIIEYLTIHAFKVTAVADSTQFTRVLSSATVDVVVVDLNLVREDGLEIVRNLAAKSDIPIIIISGDRLEETDKVVALELGASDFIAKPFSIREFLARIRVALRVRPNVVRSKDRRSFCFTDWTLNLRQRRLMSEAGGEVKLTAGEFNLLLAFLEKPRDVLSREQLLIASRVRDEEVYDRSIDVLILRLRRKLEADPSSPQLIKTARGAGYFFDADVQVSHGGTMAA
What is the function of this protein?
VirG is required for the positive regulation of at least two vir loci encoded by the Ti plasmid of A. tumefaciens.
What are the official names of this protein?
Regulatory protein VirG.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GIS1_YEAST
Sequence: MEIKPVEVIDGVPVFKPSMMEFANFQYFIDEITKFGIENGIVKVIPPKEWLELLEGSPPAESLKTIQLDSPIQQQAKRWDKHENGVFSIENEYDNKSYNLTQWKNLAESLDSRISQGDFNDKTLKENCRVDSQQDCYDLAQLQILESDFWKTIAFSKPFYAVDENSSIFPYDLTLWNLNNLPDSINSSNRRLLTGQSKCIFPWHLDEQNKCSINYLHFGAPKQWYSIPSANTDQFLKILSKEPSSNKENCPAFIRHQNIITSPDFLRKNNIKFNRVVQFQHEFIITFPYCMYSGFNYGYNFGESIEFILDQQAVVRKQPLKCGCGNKKEERKSGPFSNLSYDSNESEQRGSITDNDNDLFQKVRSFDELLNHSSQELQNLEDNKNPLFSNINMNRPQSSSLRSTTPNGVNQFLNMNQTTISRISSPLLSRMMDLSNIVEPTLDDPGSKFKRKVLTPQLPQMNIPSNSSNFGTPSLTNTNSLLSNITATSTNPSTTTNGSQNHNNVNANGINTSAAASINNNISSTNNSANNSSSNNNVSTVPSSMMHSSTLNGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLSSPMNPNGHTSYNGNMMNNNSGNGSNGSNSYSNGVTTAAATTTSAPHNLSIVSPNPTYSPNPLSLYLTNSKNPLNSGLAPLSPSTSNIPFLKRNNVVTLNISREASKSPISSFVNDYRSPLGVSNPLMYSSTINDYSNGTGIRQNSNNINPLDAGPSFSPLHKKPKILNGNDNSNLDSNNFDYSFTGNKQESNPSILNNNTNNNDNYRTSSMNNNGNNYQAHSSKFGENEVIMSDHGKIYICRECNRQFSSGHHLTRHKKSVHSGEKPHSCPRCGKRFKRRDHVLQHLNKKIPCTQEMENTKLAES
What is the function of this protein?
Transcription factor involved in the regulation of gene expression upon nutrient starvation.  Recognizes and binds to the post-diauxic-shift element 5'-T[AT]AGGGAT-3' in the promoter region.  Can act as a transcriptional activator (e. g.  of stress genes like SSA3, HSP12 and HSP26) as well as a repressor (e. g.  of pyrophosphate phosphatase DPP1).  GIS1 also acts as a DNA damage-responsive transcriptional repressor of photolyase PHR1.
What are the official names of this protein?
Transcriptional activator/repressor GIS1.
Protein: Y0419_STAS1
Sequence: MVELQDKVAVVTGASSGIGASIAETLANQGVKVVLTGRDESRLAEVAKRIQDNKQAVVETSIVDVTHKEEVTELVEKTKEKFGQIDILVNSAGLMLSSAITEGDVEAWEAMIDVNIKGTLYTINAVLPSMLNQSSGHIINIASISGFEVTKKSTLYSASKAAVHSITQGLEKELAKTGVRVTSISPGMVDTPLSGDTDWGARKKLDPKDIAEAAIYALQQPSHVNVNEVTVRPV
What are the official names of this protein?
Uncharacterized oxidoreductase SSP0419.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: UXAC_RHIWR
Sequence: MTAAPLRLHPDRLFPADPDTRVVARRLYAEVAGLPIVSPHGHTDPRWFAEDAPFGDASSLLLQPDHYVFRMLYSQGVPLEAIGIGAPVDPRAAWRVLADHYHLFRGTPSRLWLDWVFHSVFGLDVRLAPETADLTFDSINEQLARPEFRPRALFDRFNIELLATTESPLDPLDHHAAIRASGWTGRVITAFRPDPVVDPDFEGFAANLDRLGAMTGEDVGSYAGYLAALRARRAAFAAAGATSTDHGHPTAATADLDRGEAERLYAQVRGGGATAEQAELFRAHMLTVMAEMSIDDGLVMQIHPGSFRNHNADLFRRFGRDKGADIPTRTDFVRALRPLLGRFGNDPRLSLILFTLDESAYARELAPLAGHYPALKLGPAWWFHDSPEGMRRFRRQTTETAGFHNLVGFNDDTRAFLSIPARHDVARRIDCGYLAELVVEHQLDEDEAADLAVDLTYRLVKSAYRL
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: Y939_SULTO
Sequence: MKRNTLLALVLVILIFPTLSTAYIEFTTSINQAIPDSLVYATSAYYDGKIFLIGGENLYSTPVNSVYVYENGSWYLGPSLPFSLSSAGATVCNNTLYVVGGANSTSIFGGILEFIGNGWKVITNSMPIPVYGAIVFSYDYKIYVIGGMNYSGNSLVPPVNYIQVYNLKTNSWQIIGNAPLRLAYSAYYFNGSALFVVGGFTQSATLTSSVFVYYPENNTWISLPSLPGVEAGGVLGYYNGYMYLVGGLYYVSGAYQLGEILYYYNGTWRNTNIQEQIPTQFSTSVQIGNKLIILGGFGPGNIPSNAMQTVSIYLPPPKPQIASIASGNETITVKWYDTNASGYYITYWSNFSQKVTINVGNVTSYTIKHLKDGVTYYIQIVPYNSLGNGTPSDIISATPSSVPNPPIIKVKIGNLNATLTWYDTFNGGYPIEGYYLYVNGKGINVGNITSYVLTNLTAGELYTIELIAYNKIGNSSISSVSFIAASKANLTVTVYKKINGFLVSWNSTSKAKYILTVSKENVVLLNVSTTNTSYFVKVPFGVYNISLEAVNIVGITKYAFILIYYIQPASPTVNWSITLNTVSLNWSKVSGAEYYLIYDNGKLITNTTNTAFTFNLTIGQNEIEVYAANAYYKSAPYIINDVRNYIVVVNSTAISISVPQIKVVSGENTDAPLQTNNIDLKSAIIVITVFVIALLMILVILRERSDNYW
What are the official names of this protein?
Kelch domain-containing protein STK_09390.
Protein: YQGF_CHLPB
Sequence: MGKIPIKRILAIDYGKKRTGLAKTDPFCSFAQPVGTFPPEKIITIIKSFLQENSVEKIIVGYPLNSDGTKNPMTGIIDGFIEELSAAFPDIPVEPIDEHGSSKQAGKVLIESGLSRKKRQRKGRLDSAAACLLLQHYLENTGNA
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_SHEHH
Sequence: MAATQYYGTGRRKTSTARVFAKVGTGNIIVNKLPLDEYFGRETSRMVVRQPLELVEMTDKLDIMVTVKGGGNTGQAGAIRHGITRALMELDESLRPSLRAAGFVTRDARKVERKKVGLRKARRKPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: CLPP_ALIFM
Sequence: MSYQENNAMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKKKLNTLLAEHTGQPLEVIEQDTDRDNFMSADDAVKYGLVDAVLNKRD
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPPC_MYCTO
Sequence: MESPMTSTLHRTPLATAGLALVVALGGCGGGGGDSRETPPYVPKATTVDATTPAPAAEPLTIASPMFADGAPIPVQFSCKGANVAPPLTWSSPAGAAELALVVDDPDAVGGLYVHWIVTGIAPGSGSTADGQTPAGGHSVPNSGGRQGYFGPCPPAGTGTHHYRFTLYHLPVALQLPPGATGVQAAQAIAQAASGQARLVGTFEG
What are the official names of this protein?
Putative lipoprotein LppC, UPF0098 protein MT1962.
What is the protein family that this protein belongs to?
Belongs to the UPF0098 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: TFE_METS5
Sequence: MTGNIDQLMKDMARDLLGEDVIDVLSFLLDNKTELTDEEMANKLNVKVNEVRKKLYALAEHGLVSYRRTRDKETGWYVYYWKANVDQINELLLSRKREILNKLKARLEYETNNEFYICPEDKTKYTFEEAFENEFKCPKCGVQLVYYDSAKMREFLERKIKEIEEEIARETKVGSS
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: DDX23_DICDI
Sequence: MDPPKLTFISKRDTKKKDEVNKEQPTKNLKILDLFSNDEEFSNPTQEEPTNTLQEKLMNVDPLEFFSKGGLKEEQKKERDDHRDDYRDSRDRDRDYRDNGGRDRDRDYRDGGGGGGGRDRDRNRDRDRDRDRDYRDGGGGRDRYRDNDRYRDTDRYRDNDRRDGSGSGSSRRRDERRENSGRRDYRDNDRRDDRRDNGRYGRDNDNSGGGGSGKNSSDKKEEINPVSNNNDIHKDRIKRDTTQFSHKVFEQINNKRDREDPELRDIKVDYMGIKRDENRKKIKGEKGKFVFEWDSSEDTSSDYNTLYTKKLEIQPQFGHGNFGGYEKNNNNNGNHYNGNIYNNNNNNNNNNNNNNNINNNNNGSMIGGKQISELPDTHWSKKPLKSMTKRDWHIFKEDFNISTKGGIAPNPIRTWQESNLPREILEAIRQLGYEKPSPIQMQSIPISLTGRDILGIAETGSGKTCAFVIPMLIYISKQPRLTKDTEADGPYALVMAPTRELVQQIEKETRNFAQHFGFRVVSLVGGQSIEDQAYQVSKGCEIIIATPGRLNDCLEKRYLVLNQCNYIVLDEADMMIDLGFEPQVTSVLDAMPSSFLKSEDDEMAEKQESDRSHIYRTTILFSATMPPLVEKLSKKYLRRPCTITIGEAGKVVDRIRQTVIFVKSENDKKEHLTQLIKDGPPPPIIIFVNKKKHCDIIAPVLEECRVSYTILHSGRSQEQREAALEGFKKRKYEVLIATGVASRGIHVDGVTHVINFDIPKNIEDYTHRIGRTGRAGSAGLASSFITDKDVEIMYDLKQILTSTNNIVPIELLKHPSSQQKHGSSKDHNKSVIFK
What is the function of this protein?
Probable ATP-dependent RNA helicase which may be involved in mRNA splicing.
What are the official names of this protein?
ATP-dependent RNA helicase ddx23, ATP-dependent RNA helicase helB2, DEAD box protein 23.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y1472_THEKO
Sequence: MFAEVLTIGDELLTGHTVDSNSAFIASKLTEQGYWVRRITTVGDDVEEIKAVVGEILARKPEVLVISGGLGPTHDDVTMLAVAEALGRKLVLCEKCLERIKAFYEKLYSEGYIDDPSLNEGRKKMAYLPEGAEPLENTGGAAPGAFIEHKGVKIFVLPGMPREMKAMLEKEVLPRLGRRKFLQRKFLAEITDESKLAPILREALERFNVRIHSSPKGFGKYIGLIIFAEDEGELEKTVEYLESRGIRLEEA
What are the official names of this protein?
Protein TK1472.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: DNAJ_RHOCA
Sequence: MAKVDFYEVLGVSKGASAEEIKKAYRSKAKELHPDRNQGQSAAEAQFKEVNGAYDVLKDGDKKAAYDRYGHAAFEGGMGGGGPRGPYGQGADFSSAFSDVFEDLFGDFMGGRGGPGGGGRRVRRRGSDLRYNMRVTLEEAFKGAQKTITVPGSAACGSCNGTGAEGGAEPQTCPTCSGLGKVRAQNGFFTVERTCPTCGGQGQVVKNPCRVCHGSGRIEKERTLSVNIPAGVETGTRIRLAGEGEAGMRGGPSGDLYIFIEVREHAIFQRDGVNLFCRVPVSMVSAALGGEVEVPTIDGGRSKVKVPVGSQSGRQMRLRGKGMPALRGGGIGDMVIELAVETPVNLTARQKELLDEFQRIQAENNPEGASFFQKVKSFWDGMKG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COL_BOVIN
Sequence: MEKVLILLLVALAVAYAVPDPRGIIINLDEGELCLNSAQCTSKCCHREDGLSLARCAPKASENSECSAFTLYGIYYKCPCERGLTCNVDKTIVGSITNTNFGVCLDLGRATE
What is the function of this protein?
Enterostatin has a biological activity as a satiety signal.
What are the official names of this protein?
Colipase.
What is the protein family that this protein belongs to?
Belongs to the colipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: FGFR2_PLEWA
Sequence: MFSWSYLMGLVMVATATLSLARPSYNIAEDTTLEPEEPPTKYQISQPDVHSALPGESVELRCLLGDAIMVTWTKDGAQLVSNNRTLLIGPYLQIREAAPRDSGLYACGATRPLQSETRYFIVNITDGNSSGDDEDDNDGSEDFTNDNNHKRAPYWTNTEKLEKKLHAVPAANTVKFRCPAGGNPLPSMRWLKNGKEFKQEHRIGGFKVRSQHWSLIMESVVPSDKGNYTCIMENEYGSINHTYHLDVVERSPHPPILQAGLPANTTTKVGGDREFVCKVYSDAQPHIQWRHIELNGSKIGPDGNPYLKVLKAAGGNTTVKEIEVLYVRNVSFEDAGEYTCLAGNSIGISYHSAWLTVLPDEERQLDSSSSEYTEIAIYCVGGFLIACMIGTIMMCHMKGRGKKSDFSSQPAVHKLSKRLPLRRQVTVSADSSSSMNSNTPLVRITTRLLSNTDTHLLAGVSEYELPEDPKWEYPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKDAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRTRRPPGMEYSFDIFRIPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTETNVIKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTLQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMVKPGNCTNELYTMMTDCWRAVPSQRPTFKQLVEDLDRILTQTTNEEYLDLNNPLEPYSPSYPDTRSSCSFGDDSVFSPDPMSMNLAFPNPNTQMAPLKHEATQPA
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development.  Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development.  Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development.  Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts.  Phosphorylates PLCG1, FRS2 and PAK4.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation.  Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling.  Over-expressed FGFR2 promotes activation of STAT1 (By similarity).
What are the official names of this protein?
Fibroblast growth factor receptor 2, FGFR-2, PFR2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded (By similarity).
Protein: RLMKL_HAHCH
Sequence: MNEFSLFASCPKGLEYVLADELKTLGAEVLRTNPAGVEAKVDLAGAYRICLGSRLANRVLRLLQSTRTATRDGLYQAASEVNWSEHLRPGESYWIAAFGSSGDIRHSRFGAQVVKDAINDHFRDRDLELPVIDKRSGVQTVQLNLAKTITLGLDLAGRSLHQRGYRQEGAAAPLKENLAAAILYRAGWPEICGEDGCFVDPMCGSGTLVVEAAMIAMNIAPGLLNPHFLFEKAPWHDPEVWRGVYEEAMEKAVLGKRRWRGAIFGCDLNPAAIRTAKRNLSRAGLDRWVKLETASAMDFTPDTEGCGQRLLVCNPPYGERLGQELELRSLYRALGRRLKTAYGEWKAGIFTSSVNLAKEIGLRADKQYHLYNGPLATTLYLFDVYGNRPEAETPRKPQNASLEGISEQAQMFRNRLSKNLAKWSKWAKKQQLSAYRIYDADMPEYAVAIDWYDGGIIVQEYAPPKSVDEEKARQRLLDVLEVTPAVLGIDGGQLFLKQRKKQKGMLQYEKTDSSRKERTVEEHGCRFWVNLSDYLDSGLFLDHRPTRYWIQKHSSGKRFLNLFCYTGAASVHAAAGGAATTTSVDMSQTYLSWAERNFHLNKLSGPHRFVRANVLDWLKAEHNSYDLIFLDPPTFSNSKKMEDVLDIQRDHAGLIEDCMRLLAPGGVLIFSCNYRRFKLDSGIEQRFAVENHTAASIPEDFKRNERIHQCWHIRHSA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_PROMS
Sequence: MQFSTFQTNLDNWQGASLIFGVLEEEIASQLENIKFVVDPKLLLKKVTQKKFKGEKGKTLSFEFLDQKLETLIIVGLGKSKDLNKSDIENSIGNLVRKTVDKNAKISILLPWELINSQLEITKLAESARLSAYKDNRFNKKKDEKKVLKEIEFLNLKQFENISFEETAQICEGVELARKLVAAPPNSLTPQEMSLQASKIAKDHGLEVKILEAKDCEDLEMGAYLAVAKGSDLDPKFIHLTLKSEGPIKEKIALVGKGLTFDSGGYNLKVGASQIEMMKYDMGGSAAVLGAAKALGAIKPKGLEIHFIVAACENMINGSAVHPGDVVKASNGKTIEINNTDAEGRLTLADALTYASNLNPDSIIDLATLTGAIVVALGNDVAGFWSNNDDLANDLKAASAQSGEKLWQMPLQKSYKEGLKSHIADMKNTGPRAGGSITAALFLEEFFDSEIKWAHIDIAGTCWTDKNKGINPSGATGFGVKTLVQWIKNK
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.