PharMolix/UniProtQA huggingface dataset:
Protein: TRHBN_MYCTU
Sequence: MGLLSRLRKREPISIYDKIGGHEAIEVVVEDFYVRVLADDQLSAFFSGTNMSRLKGKQVEFFAAALGGPEPYTGAPMKQVHQGRGITMHHFSLVAGHLADALTAAGVPSETITEILGVIAPLAVDVTSGESTTAPV
What is the function of this protein?
Binds oxygen cooperatively with very high affinity (P(50) = 0. 013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1). sec(-1)) and a slow dissociation (0. 2 sec(-1)) rate.
What are the official names of this protein?
Group 1 truncated hemoglobin GlbN, Truncated hemoglobin, trHbN, Hemoglobin-like protein HbN.
What is the protein family that this protein belongs to?
Belongs to the truncated hemoglobin family. Group I subfamily.
Protein: PURA_GEOTN
Sequence: MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIVFNGEKYKLHLIPSGIFYKDKICVIGNGMVVDPKALVAELSYLHEHGISTDNLRISNRAHVILPYHLKLDGLEEERKGANKIGTTKKGIGPAYMDKAARIGIRIVDLLDRDVFAEKLARNLEEKNMLFEKVYGVEGFRHEDIFEEYYEYGQQIAKYVCDTSVVLNNALDEGRRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGAGVGPTKIKHVVGVAKAYTTRVGDGPFPTELHDEIGDRIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVLTGIETLKICVAYRYRGEVIEEFPASLKVLAECEPIYEELPGWTEDITGVRSLDELPANARHYVERISQLTGIPLSIFSVGPDRSQTNVVRSVYA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_CANAL
Sequence: MSDVEEQYQEEQQPVVQEELQVVELATTIPLDVQEAQREVKLFNKWSFEDVEVKDVSLVDYIQIRNPVFVSHTAGKYASKRFRKAQCPIVERLTNSLMMNGRNNGKKLKAVRIVKHALEIIHVLTEQNPIQVVVDAIVNSGAREDSTRIGSSGTVRRQAVDVSPLRRVNQAIALLTIGAREASFRNIKTIAECLAEELINAAKGSSTSYAIKKKDELERVAKSNR
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
40S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: DEF7_RABIT
Sequence: GICACRRRFCLNFEQFSGYCRVNGARYVRCCSRR
What is the function of this protein?
Microbicidal activity and inhibits corticotropin (ACTH) stimulated corticosterone production.
What are the official names of this protein?
Corticostatin-6, Corticostatin VI, CS-VI, Neutrophil antibiotic peptide NP-6.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGC_BACFN
Sequence: MIKAGIIGGAGYTAGELIRLLINHPETEIVFINSTSNAGNKITDVHEGLYGECDLAFTDELPLEDIDVLFFCTAHGDTKKFMESHNIPEELKIIDLSMDYRIASPDHDFIYGLPELNRRATCTAKHVANPGCFATCIQLGLLPLAKHLMLNEDVMVNAITGSTGAGVKPGATSHFSWRNNNMSVYKAFEHQHVPEIKQSLKQLQNSFDAEIDFIPYRGDFPRGIFATLVVKTKVALEEIVRMYEEYYAKDSFVHIVDKNIDLKQVVNTNKCLIHLEKHGDKLLIISCIDNLLKGASGQAVHNMNLMFNLEETVGLRLKPSAF
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WNT9_EPTST
Sequence: SGSCTVRTCWRQLAPFTEMGRSLKQRYDVAVKVLSMTNEAAGERTIARSRRRPREQRGQRRPKVSDGALTPRGIDLVYVEDSPSYCRASRYSPGTANRSCQKGRNCDSICCGRGYNTRVSSVQKPCQCQV
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.
What are the official names of this protein?
Protein Wnt-9.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: KNG2_BOVIN
Sequence: MKLITILFLCSRLLPSLTQESSQEIDCNDQDVFKAVDAALTKYNSENKSGNQFVLYRITEVARMDNPDTFYSLKYQIKEGDCPFQSNKTWQDCDYKDSAQAATGQCTATVAKRGNMKFSVAIQTCLITPAEGPVVTAQYECLGCVHPISTKSPDLEPVLRYAIQYFNNNTSHSHLFDLKEVKRAQKQVVSGWNYEVNYSIAQTNCSKEEFSFLTPDCKSLSSGDTGECTDKAHVDVKLRISSFSQKCDLYPGEDFLPPMVCVGCPKPIPVDSPDLEEALNHSIAKLNAEHDGTFYFKIDTVKKATVQVVGGLKYSIVFIARETTCSKGSNEELTKSCEINIHGQILHCDANVYVVPWEEKVYPTVNCQPLGQTSLMKRPPGFSPFRSVQVMKTEGSTTVSLPHSAMSPVQDEERDSGKEQGPTHGHGWDHGKQIKLHGLGLGHKHKHDQGHGHHRSHGLGHGHQKQHGLGHGHKHGHGHGKHKNKGKNNGKHYDWRTPYLASSYEDSTTSSAQTQEKTEETTLSSLAQPGVAITFPDFQDSDLIATVMPNTLPPHTESDDDWIPDIQTEPNSLAFKLISDFPETTSPKCPSRPWKPVNGVNPTVEMKESHDFDLVDALL
What is the function of this protein?
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e. g.  prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
What are the official names of this protein?
Kininogen-2, Kininogen II, Thiol proteinase inhibitor.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: YACG_ACIAD
Sequence: MKDFIMPRTFPCPRCGQPSVWEGNESRPFCSERCKLIDLGAWASEEYKLKTQDAPTSGKGQHSDDYED
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: MEND_CHLL2
Sequence: MNNREITSLWSRIIIEELVRLGAGFFCISPGSRSTPLTVAAARHPEAAWKMFPDERSAGFFALGYARATQKPAVLICTSGTAVANYYPAVVEASMDCQPMLILSADRPFELLETGANQTIQQFGIFGGYSRWNFRLPEPSSDVPLRSVITAIDHAVSSATGSLPGPVHINVPFREPFEPLDPDLHDPWLAPVSEWIDTSTPLCRTLSQERVPNRESISSLRKIIAESKLPFMIAGRLNNRSDSLAVGNLARSLNIPLYADLSSGLRLDSSFNPLQLAFQSSQFPERFRPDTVIHFGGPLVARQPSAAVRMWNPRNHIVIKPHANRFGPDHNITLSIEASPALIAEALLGCRTPLPSGCQPLPEPFFQQAKAEIDICCLPDHPVSEISAARIVSSLVTPESGLFLSNSMPVRDMDLYASPSASRPFMTGMNRGASGIDGIISTAAGFAKGLRKPVTLMIGDIAFLHDLNALSLLPSLQVPLCIVVLNNNGGGIFSFLPVASEKDVFETCFATPQSYSIKAAAETFGIESSRPATNRDFEECCRKAAESDRCSIIEVKGNRRNNVELHRTLQSKITALGASYLSR
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: MDV1_CRYNJ
Sequence: MANHHDHDKPLRSALDPISSPYFSSLNGTLSIAKEVLIGPFQGDHRRSESARILSDLAPSLMQPRFLNAASSSQQSLSKSSHPGAPYPLLRLPTNLPFNKSSRPTASSLAILEAVDNLASLSLGDVSHPQNGQNSPSLIRGFKATIPSSELAKQRRRMVRGGIVDEDLGGKIGLKKLGDRARGLLTEKGEDEEDGELGVGRHAVKKRRKKRESRRFTEGRHLEGKLRLEDLAKQADEIGQDKENLHVRQSLIQSEIAEVGAKIDALEDIRRHLEASLLHLQEEDLELDDELEGVQELMASPAIKAAAGAKSLPLSSSGAGISNKSSRRRKGPAFLPSEHDELPSGVAFMTLNGHTAPITALDFDEPYGMLVTAGQDDVVKVWDLCDGEEIGQLRGHRGTVKALQVEDTLCLTGGADGNVRLWDLRMVEDYEERLHTQLAELARQDPLERIAEQRAHEEDGEHAEQDDELPDGTLQDPQPGDGSPCVRTLEGHSKSVTSLYYEDGCLVTGSSDKTIRQWDVATGQCVLTMDILWAISNPPPPPSSVPPQRPPRLSHRSSTSFGSNTYEDILPSPGASLVGMSGAALLGAATGQNFAVPTPPYADGTWEMYQDFVGGVQFWGYALASGSGDGGVRMWDMRTGQAHRTLIGHTAPVTCLQFDEQYIVTGSLDRTVRIWDLRMGSVSEVHKYEYPVTALQFDSRKVVACTGENGVEVYNRTTHAHSRLVVNGHTKPAEKMRFIDKYLVSGGRDGCAKVWAM
What is the function of this protein?
Involved in mitochondrial fission.  Acts as an adapter protein required to form mitochondrial fission complexes.  Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
What are the official names of this protein?
Mitochondrial division protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MDV1/CAF4 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FADI_VIBVY
Sequence: MGKQEVKTRQGERVAIVAGLRTPFARQSTEFSQVPAVDLGKMVVSDLLARTDIDPKLIDQVVFGQVVQMPEAPNIAREIVLGTGMNIHTDAYSVTRACATSFQSAVNVAESIMAGAIDIGIAGGADSSSVLPIGVSKKLAASLLALSKTKTLGQKLKVLSGLGLKDLMPVPPAVAEYSTGLSMGQTAEQMAKTHGITRAEQDALAHRSHTLASQAWRDGKIAGEVMTAFPEPYKKWIAEDNNIRHDSTLEGYAKLRPAFDRQYGSVTAANSTPLTDGAAAVLLMREGRAKELGMEILGYIRGYAFSAIGVESDMLMGPSYATSKVLQSTGLALSDLTLIDMHEAFAAQALANVKMFASDKFAQENLGRSKAMGEIDMDKFNVLGGSIAYGHPFAATGARMMTQTLRELKRRGGGLALNTACAAGGLGAAMILEVE
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, ACSs, Acetyl-CoA acyltransferase, Acyl-CoA ligase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIGM_TRYB2
Sequence: MELQSLIDTVSLQKLLLLGALLRLILIAYAFFHDQWFRVKYTDIDYMIVVDGARHMWNGGSPFDRTTFRYTPLLAALVMPSIWIANPMGKLIFASSDLGAAWYCYGVLKSFAKERSAKWMVSLFILFNPIVLSVSTRGNSDMLVTFMSLMVLSKFARRKCYQAAAVLGFAVHFKIYPIIYALPLTLGVWEQSVAASTNTWRRVVKTAVVVSICALMAAISFAVPTVLCYMKYGQQYLNEAFIYHVYREDHRHNFSPYWLLMYLNMARRHLGQGVDFSPRLVAFAPQAVVLSFVSYKLRRNTAHACCVQTVLFVAFNKVCTVQYFVWFIPFLAFLFCEPKEVEDDESGGSGAFKFFSWVKALGVVLMWAATIPLWVTTAVPLEFHGYSDFAQLWIVSCLFFLAMVVLASMLARIAYRVQCTKCSAKSIKVA
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the first alpha-1,4-mannose to GlcN-PI during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 1, GPI mannosyltransferase I, GPI-MT-I, Phosphatidylinositol-glycan biosynthesis class M protein, PIG-M, TbPIG-M.
What is the protein family that this protein belongs to?
Belongs to the PIGM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ALKB6_HUMAN
Sequence: MEEQDARVPALEPFRVEQAPPVIYYVPDFISKEEEEYLLRQVFNAPKPKWTQLSGRKLQNWGGLPHPRGMVPERLPPWLQRYVDKVSNLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPTVSTISLGSHTVLDFYEPRRPEDDDPTEQPRPPPRPTTSLLLEPRSLLVLRGPAYTRLLHGIAAARVDALDAASSPPNAAACPSARPGACLVRGTRVSLTIRRVPRVLRAGLLLGK
What is the function of this protein?
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.
What are the official names of this protein?
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6, Alkylated DNA repair protein alkB homolog 6.
What is the protein family that this protein belongs to?
Belongs to the alkB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TLP_BACCZ
Sequence: MPNPDNRSDNAEKLQEMVQNTIDNFNEAKETAELSNEKDRSAIEAKNQRRLESIDSLKSEIKDES
What are the official names of this protein?
Small, acid-soluble spore protein Tlp.
What is the protein family that this protein belongs to?
Belongs to the Tlp family.
What are the subcellular locations of this protein?
Spore core.
Protein: AROB_PSEE4
Sequence: MQTLKVDLGERSYPIYIGEGLLDQPELLAPHIAGRQVAIVSNETVAPLYLERLSKTLGAYSVLPVVLPDGEKYKNWETLQLVFDALLSARHDRRTTVVALGGGVIGDMAGFAAACYQRGVDFIQVPTTLLSQVDSSVGGKTGINHPLGKNMVGAFYQPNAVLIDTTSLKTLPQRELSAGLAEIIKYGLICDEPFLGWLEDNMQALRALEPVALTEAIRRSCAAKAAVVGADERESGVRATLNLGHTFGHAIETHMGYGVWLHGEAVAAGTVMALEMSMRLGWIDQPARDRGIRLLQDAGLPVVPPQEMTPAHFMEHMAVDKKVLDGRLRLVLLRQMGEAVVTDDYPKEILQATLAADYRAIVAQL
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_AERHH
Sequence: MQKFDVKTFQGLILQLQDYWSRQGCTIIQPLDMEVGAGTSHPMTCLRALGPEPIACAYVQPSRRPTDGRYGENPNRLQHYYQFQVIIKPSPDNIQELYLGSLKELGMDPEIHDIRFVEDNWENPTLGAWGLGWEVWLNGMEVTQFTYFQQVGGLECKPVTGEITYGLERLAMYIQGVDSVYDLVWSDGPLGKTTYGDVFHQNEVEQSTYNFEHADVEFLFHCFEQYEKEAQNLLALEKPLPLPAYERILKAAHSFNLLDARKAISVTERQRYILRIRTLTKAVAEAYYASREALGFPMCQRSENKQG
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDRG3_BOVIN
Sequence: MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETAHGMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLNLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILSHHFGQEELQANLDLIQTYRLHIAQDINQENLQLFLGSYNGRKDLEIERPILGQNDNKSKTLKCSTLLVVGDSSPAVEAVVECNSRLNPVNTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSIGSGESAFSRSVASNQSDGTQESSESPDVLDRHQTMEVSC
What are the official names of this protein?
Protein NDRG3, N-myc downstream-regulated gene 3 protein.
What is the protein family that this protein belongs to?
Belongs to the NDRG family.
Protein: KAD_STRPG
Sequence: MNLLIMGLPGAGKGTQAAKIVEEFGVAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVPDEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSCLVERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNMAQGEPILEHYRKLDLVTDIEGNQEITDVFADVEKALLELK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNP1_THESM
Sequence: MWRNSQKWKNRASRRPQRKGEALIDKLWIFRGLDRGRMTKKTLLMHELIGLKVKVVKSSHPGLIGIEGYVIDETKNTLTILGTKVWAIPKIVAEFEFEVGDKKIRIKGEELVGRPEMRLKKR
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 1, RNase P component 1, Rpp29.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK33_CYAPA
Sequence: MARAKGVRILVTLECTECRSNGERLGGGVSRYATKKNRRNTPNRLELNKFCPYCKKHVLHREIK
What are the official names of this protein?
50S ribosomal protein L33, cyanelle.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: CBPA_COXBN
Sequence: MEYQDYYKILGVSRDATADEIKKSYRKLARKYHPDVSSEPNAEEKFKQVKEAYEVLKDVEKRKAYDAIGSGWKQGQGFTPPPGWESRPGGEGVRPEFREGFSDFFESLFGGLGQEARWTRQEFKQRGQDQHSRVTVSLEEAFNGSTRLLTLQEPIVDYQTGQVTSKTRQLRIKIPAGVTEGQQIRLQGQGLPGIGGAPNGDLYLEIHLAPHSLFTVEGKDVYLNLPVTPWEAALGAKVSIPTLGGSVDLTLPPGSQTGQKLRLKGRGLPGGTPGDQYVLIKIYIPEPKNDQQKELYQQMAEQMPFDPRKELLG
What is the function of this protein?
DNA-binding protein that preferentially recognizes a curved DNA sequence.  It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock.  Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK.  Its activity is inhibited by the binding of CbpM.
What are the official names of this protein?
Curved DNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: VDAC1_PIG
Sequence: MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHVNLGCDVDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane and also the plasma membrane.  The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis.  It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.  The open state has a weak anion selectivity whereas the closed state is cation-selective.  Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol.  In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis.  May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.  May mediate ATP export from cells.
What are the official names of this protein?
Voltage-dependent anion-selective channel protein 1, VDAC-1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: PHAF1_RAT
Sequence: MLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNLTQDGIKLLFDAFNQRLKVIEVYDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVYNSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGLASLQIPHGATVKRMYIYSGNSLQDTKAPMMPLSCFLGNVYAESVDVIRDGTGPSGLRLRLLAAGCGPGVLADAKMRVFERAVYFGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPSPHKQVPSKCNDYFFNYFTLGVDILFDANTHKVKKFVLHTNYPGHYNFNIYHRCEFKIPLAIKKENAGGQTEICTTYSKWDSIQELLGHPVEKPVVLHRSSSPNNTNPFGSTFCFGLQRMIFEVMQNNHIASVTLYGPPRPGAHLRTAELP
What is the function of this protein?
Plays a regulatory role in autophagic activity.  In complex with BCAS3, associates with the autophagosome formation site during both non-selective and selective autophagy.
What are the official names of this protein?
Phagosome assembly factor 1.
What is the protein family that this protein belongs to?
Belongs to the PHAF1 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure. Note=The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner.
Protein: WZYE_SALEP
Sequence: MSLMQFSGLLVVWLLSTLFIATLTWFEFRRVRFNFNVFFSLLFLLTFFFGFPLTSVLVFRFDVGVAPPEILLQALLSAACFYGVYYVTYKTRLRKRVVDVPRKPLFTMNRVETHLTWVILMGIALVSVAIFFMHNGFLLFRLHSYSQIFSSEVSGVALKRFFYFFIPAMLVVYFLRQDSKAWLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGLNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYHNIDFQGLAPIVRDFYVFIPTWLWPGRPSIVLNSANYFTWEVLNNHSGLAISPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNREPNRYKAAILHSFCFGAIFNMIVLAREGLDSFVSRVVFFLVVFGASLLVAKLLFWLFDSAGLIHKRTTSLPQAQVEGKL
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPE_GEOSW
Sequence: MRLLVKAPAKINLSLDVLHKRPDGYHEVKMVMTTIDLADRIELIPQMDDTIQIISKNRFVPDDHRNLAYQAAKLLKDTFAIKQGIAISITKNIPVAAGLAGGSSDAAATLRGLNKLWNLGLTLDELAELGAKIGSDVSFCVYGGTAIATGRGEKITPIPAPPPCWVILAKPSIGVSTAEVYRNLKVDEIPHPDVDGMVEAIYRQDYAAICKLVGNVLEEVTLKKYPEVAHIKEQMKRFGADAVLMSGSGPTVFGLVQHDSRLQRIYNGLRGFCDQVFAVRILGERHSLD
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: GLYA_MYCA1
Sequence: MSAPLADIDPDIAGLLGQELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEYVDVVENIARDRAKALFGADFANVQPHSGAQANAAVLHALMTPGERLLGLDLANGGHLTHGMKLNFSGKLYDVGFYGVDPTTHLIDMDAVRAKALEFRPKVIIAGWSAYPRVLDFAAFASIADEVGAKLWVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGPRSGLILGKQEYAKSINSAVFPGQQGGPLMHVIAAKAVALKIAGTEEFADRQRRTLSGARILAERLSGADVAAAGVSVVSGGTDVHLVLVDLRNSELDGQAAEDLLHEIGITVNRNAVPNDPRPPMVTSGLRVGTPALATRGFGDAEFSEVADVIATALAGGRGADLAALRDRVTRLARDFPLYEGLEDWALVGR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQA_DINSH
Sequence: MAWTKPIIREIECGMEINMYGPDSDEEREVLF
What is the function of this protein?
Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis.  PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide.
What are the official names of this protein?
Coenzyme PQQ synthesis protein A, Pyrroloquinoline quinone biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the PqqA family.