PharMolix/UniProtQA huggingface dataset:
Protein: SYP_STRZP
Sequence: MKQSKIPIPTLREMPSDAQVISHALMLRAGYVRQVSAGVYSYLPLANRVIEKAKNIMRQEFEKIGAVEMLAPALLSAELWRESGRYETYGEDLYKLKNREKSDFILGPTHEETFTAIVRDSVKSYKQLPLNLYQIQPKYRDEKRPRNGLLRTREFIMKDAYSFHANYDSLDSVYDEYKAAYERIFTRSGLDFKAIIGDGGAMGGKDSQEFMAITSARTDLDRWVVLDKSVASFDEIPAEVQEEIKAELLKWIVSGEDTIAYSSESSYAANLEMATNEYKPSNRVVAEEEVTRVATPDVKSIDEVAAFLNVPEEQTIKTLFYIADGELVAALLVGNDQLNEVKLKNHLGADFFDVASEEEVANVVQAGFGSLGPVGLPENIKIIADRKVQDVRNAVVGANEDGYHLTGVNPGRDFTSEYVDIREVREGEISPDGQGVLNFARGIEIGHIFKLGTRYSASMGADVLDENGRAVPIIMGCYGIGVSRLLSAVMEQHARLFVNKTPKGEYRYAWGINFPKELAPFDVHLITVNVKDEEAQALTEKLEASLMGAGYEVLTDDRNERVGVKFSDSDLIGLPIRITVGKKAADGIVEVKIKATGDTIEVHADNVLETLEILSKK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIC19_CAEEL
Sequence: MAAQFYERNTSGMNADRFMTRLTDESTVNTMQRHYWTARQFIRTKLGKKEDEHLEASDNELDTCLNLYRSVHGTSFQLLNNVDNYANFLLDETLVQNVLGKYLKEKGKIDKTEAVGRILIAVGRSLLFSSHRLNAARIGVSTFYNKLSVFVERAIGDCSQTIEAVQMCRTEYRGSLLWMKKTSEELDPEVDGSMEKFREAQTTVKSNKERLDRLKTDTLQKVDLLSASRSNLLSYVLTHYQNELYEYYSKTSRAFETLAENINCYNNYDFEILSHLATGTKPERERKSEKEESAKTSQPRGNEEELKNLLFGRESPQFGEEEVQDESRSQCDSPLIEDVDDERRKTGDLLDLESAASIAFPIGPLATLFDTSSFVPPILPPPKPNAVSDDILSLFDGNKANSSGKEASATTMDWQSLIDGFDRENEDNLL
What is the function of this protein?
May be involved in neurotransmitter secretion (PubMed:11029035).  In association with the GTPase activator protein tbc-8 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons (PubMed:22654674).
What are the official names of this protein?
Resistance to inhibitors of cholinesterase protein 19, ICA1 homolog.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Co-localizes with tbc-8 at cytoplasmic vesicle membranes in neurons.
Protein: RAB1B_HUMAN
Sequence: MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPAGGGCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002).  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002).  Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908).  Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity).  Required to modulate the compacted morphology of the Golgi (PubMed:26209634).  Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).
What are the official names of this protein?
Ras-related protein Rab-1B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments (PubMed:11389151). In the GDP-form, colocalizes with GDI in the cytoplasm (PubMed:11389151). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri- Golgi region (By similarity).
Protein: RIMK_ECOL5
Sequence: MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIHYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGDFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIAGKMIRWIERHATTEYCLKTGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: P5I13_HUMAN
Sequence: MAPPPPSPQLLLLAALARLLGPSEVMAGPAEEAGAHCPESLWPLPPQVSPRVTYTRVSPGQAEDVTFLYHPCAHPWLKLQLALLAYACMANPSLTPDFSLTQDRPLVLTAWGLALEMAWVEPAWAAHWLMRRRRRKQRKKKAWIYCESLSGPAPSEPTPGRGRLCRRGCVQALALAFALRSWRPPGTEVTSQGPRQPSSSGAKRRRLRAALGPQPTRSALRFPSASPGSLKAKQSMAGIPGRESNAPSVPTVSLLPGAPGGNASSRTEAQVPNGQGSPGGCVCSSQASPAPRAAAPPRAARGPTPRTEEAAWAAMALTFLLVLLTLATLCTRLHRNFRRGESIYWGPTADSQDTVAAVLKRRLLQPSRRVKRSRRRPLLPPTPDSGPEGESSE
What is the function of this protein?
May act as a tumor suppressor.  Inhibits tumor cell growth, when overexpressed.
What are the official names of this protein?
Tumor protein p53-inducible protein 13, Damage-stimulated cytoplasmic protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein; Extracellular side. Cytoplasm. Note=Associates with unknown subcellular structures in the cytoplasm.
Protein: SYR_PSEFS
Sequence: MKDTIRQLIQQALTQLVNEGVLPEGLTPAIQVENTRDKTHGDFASNIAMMLSKPAGMKPRDLAEKIIAALPVDDSVTKAEIAGPGFINFFQNTQALAGRLDAALADARVGVRKAGPAQRTVVDLSAPNLAKEMHVGHLRSTIIGDGVARVLEFLGDEVVRQNHVGDWGTQFGMLMAYLQENPITSDELSDLENFYRAAKKRFDESEAFADRARGLVVKLQAGDAECLALWTKFKDISLSHCQKIYELLNVKLTMADVMGESAYNDDLINVVNDLKAAGMLVESNGAQCVFLDEFKNADGEPLPVIIVKADGGYLYATTDLAAVRYRSGTLKADRALYFVDQRQALHFQQVFAVARKAGFVTHPMDMEHMGFGTMNGADGRPFKTRDGGTVKLIDLLTEAQERAYTLVKEKNPELAEADLRNIARVVGIGAVKYADLSKHRTSDYSFNFDLMLNFEGNTAPYLLYAYTRVAGVFRKLGKDFSEVEGQIDLQASHEQELAAKLAQFGEVLNSVGEKGTPHILCTYLYEVAGLFSSFYENCPILTADDEAQKQSRLRLAALAGRTLKQGLELLGLETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_STRP2
Sequence: MSTTIIGFPRLGEFRELKFTTEKYFRKEISEEELLAAAKDLRAKHWNIVKEKGITEIPSNDFSHYDNFLDAAFLFNVVPASVQNLDLSDLERYFALGRGYQGEKGDVRALPMKKWFNTNYHYIVPKFEKDTQVKLAGHKIFDEFQEAKELGLNTRPVLVGPFTFLQLSDFEEGVKADDFVDSFVAAYQEVFAKLADLGATRIQLDEAALVKDLTAEEKALFLNLYNKLLADKKGLEVLFQTYFGDVRDVYADLVNLPVDAIGLDFVEGKKTLELVKGGFPADKTLYVGIVNGKNIWRNNYEKSLTVLEQIPAENIVLTSSCSLLHVPFTTANEEFEPALLNHFAFAVEKLDEIRDLDAIRNGQGSEALAANKELFATERVGENAELRARIAGLTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAYRKGELSQKEYDAFLAETIDEWIKWQEDIDFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGMRGVKPPIIWGDVTRLNPITVKWSSYAQSRTNKPVKGMLTGPVTILNWSFPREDISIKDSTLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVHSTVAPDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVGPGVYDIHSPRVPNEGEIDNTIEAILAKVPSKKVWINPDCGLKTRGIPETKESLIRLVEAAKAAREKL
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: CRTP_STAAN
Sequence: MTKHIIVIGGGLGGISAAIRMAQSGYSVSLYEQNTHIGGKVNRHESDGFGFDLGPSILTMPYIFEKLFEYSKKQMSDYVTIKRLPHQWRSFFPDGTTIDLYEGIKETGQHNAILSKQDIEELQNYLNYTRRIDRITEKGYFNYGLDTLSQIIKFHGPLNALINYDYVHTMQQAIDKRISNPYLRQMLGYFIKYVGSSSYDAPAVLSMLFHMQQEQGLWYVEGGIHHLANALEKLAREEGVTIHTGARVDNIKTYQRRVTGVRLDTGEFVKADYIISNMEVIPTYKYLIHLDTQRLNKLEREFEPASSGYVMHLGVACQYPQLAHHNFFFTENAYLNYQQVFHEKVLPDDPTIYLVNTNKTDHTQAPVGYENIKVLPHIPYIQDQPFTTEDYAKFRDKILDKLEKMGLTDLRKHIIYEDVWTPEDIEKNYRSNRGAIYGVVADKKKNKGFKFPKESQYFENLYFVGGSVNPGGGMPMVTLSGQQVADKINAREAKNRK
What is the function of this protein?
Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress.  Catalyzes the oxidation of the terminal methyl side group of 4,4'-diaponeurosporene to form 4,4'-diaponeurosporen-4-al.
What are the official names of this protein?
4,4'-diaponeurosporene oxygenase, 4,4'-diaponeurosporene oxidase, Carotenoid oxidase.
What is the protein family that this protein belongs to?
Belongs to the carotenoid/retinoid oxidoreductase family. CrtP subfamily.
Protein: HSCA_SHELP
Sequence: MALLQIAEPGQSAAPHQHRLAVGIDLGTTNSLVAAVRSGVADTLADESGRHALASVVRYSEDGVQVGVDAERFSAQDPLNTVVSVKRFMGRSLSDIQAKDASLPYNFSASENGLPLFNTQAGQFNPIQISADILRPLVDRAEKTLGGSLEGVVITVPAYFDDAQRQGTKEAASLLGVKVLRLLNEPTAAAIAYGLDSGQEGVIAIYDLGGGTFDISILRLNKGVFEVLATGGDSALGGDDFDHALAAHLQESWQLTSLTASERRALLIESRRVKEALTEQASVTASLTLEQGIVHEQVVDKAQFDALIESLVKKTIASCRRALRDAAISNDEVLETVMVGGSTRVPLVRERVEGFFGKAPLTSIDPDRVVAIGAAIQADILVGNKPESDLLLLDVIPLSLGIETMGGLVEKVVSRNTTIPVARAQEFTTFKDGQTAMAFHVVQGERELVADCRSLARFTLKGIPPMAAGAAHIRVTFQVDADGLLSVTAMEKSSGVQASIQVKPSFGLTDEEIGTMLKDSMAHAKEDIERRMLAEQQVEAARVLESLSAALAKDGDLLDEAEAATIQAGMANLAQVASQSDTDAIEKAIAALDDASQDFAAKRMDNSIRLALKGQSVDNI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RECR_SHEAM
Sequence: MKFSPLVDELIQSLRCLPGVGPKSAQRMAFALLESDRKAGIRLADTLSRAMSDVGHCQKCRTFTEQSLCPICSSSRRGEADTLCVVETPADVLAIESGGHFQGRYFVLQGHLSPLDGIGPEELGLSLLEGQLVGGGISELILATNPTVEGDATAHYIADIARRAGVAVSRIAHGVPVGGELEYVDSTTLALSFNGRLPL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: MURC_OCEIH
Sequence: MTTYHFIGIKGTGMSALAQILHDSGEKVQGSDFEKRFFTQEALEQKNITILPFSKENIKEDYTIIAGNAFSDDHIEIQKAKELGCKFYRYHEFLGEWLKQYTSIAVTGAHGKTSTTGLLSHVLKSAYPISYLIGDGTGNGHVDSEYFVFEACEYRRHFLKYEPDYAIMTNIDFDHPDYFTSLDDVVDAFQSMADRVKKCIVACGDDEQLQGIHTKVPVIYYGFNDSNDFQAQNVVETANGTEFDVFVRNTYYDHFIIPTYGNHTVLNALAVIAICHYEGISVEHMKQLDTFEGVKRRFTEKEIGSQIVIDDYAHHPKEISVTIESARKKYPNKNVVAIFQPHTFTRTKTFLKEFADSLNEADNVYLCDIFKSAREDSGQLTINDLQKLIPNSQLLSLKETEVLQEFKDSVLIFMGAGDIQKFQAAYEETTTKSTNFQD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_PHOLU
Sequence: MSLSTEAKAQIIAEFGRDANDSGSSEVQVALLTAQINHLQGHFSEHKKDHHSRRGLLRMVSQRRKLLDYLKRKNVTSYTALIGRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: HISZ_STUS1
Sequence: MATVDRWLLPDGIEEVLPPEAARIETARRRVLDLFQRWGYELVITPHVEFLESLLTGSGQDLDLRTFKVIDPLSGRQMGLRADITPQVARVDAHTLRREGPSRLCYAGSVLHAKPQALSTSRSPIQLGAELYGDASASSDLEVISLMLEMLELADVPDVHMDLGHVGIYRGLAKAAALSGEAEQRLFDALQRKAMDEIEQLTAALDPALASMLRALARLCGGRETLDDARHALAAAPAGVQAALETLATVADQLALRYPQVPLYFDLGELRGYHYHTGMVFAAFVPGVGQSIAQGGRYDDIGADFGRARPATGFSTDLKTLVGLGNADLTTPVAGIWAPYGDESGLWGAIRDLRRQGERVVQALDGQSQADAAQLGCDRQLQLSNGIWTVASLAS
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
Protein: GLYA_VARPS
Sequence: MYHRNILVEQTDPEIWAAIQAENARQEHHIELIASENYASPAVMAAQGSQLTNKYAEGYPGKRYYGGCEHVDVAEQLAIDRVKQIFGADAANVQPHCGASANEAVMLAFLKPGDTIMGMSLAEGGHLTHGMPLNMSGKWFNVVSYGLDANEAIDYDAMERKAHEHMPKLIIAGASAYSLRIDFERFAKVAKDVGAIFMVDIAHYAGLVAAGVYPNPVPHADVVTSTTHKSLRGPRGGIILMKSQHEKAINSAIFPGLQGGPLMHVIAAKAVAFKEAMSPEFKAYQQQVVKNAQIVADTLTERGLRIVSGRTESHVMLVDLRAKGITGKEAEAVLGSAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFRDEEARITANLIADVLENPRDAANIDAVRAKVHALTSRFPVYR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_LACJO
Sequence: MTKVTELVADVVTPLAEARGDELVDVEYVKEKKQYYLRIYVDRRPGGIDIEEIANLSELVSEKLDELDPDPFPEPYILELSSPGLERPIKNEKDWERAKGSYIHVSLYQKIDGEKTFEGTLKDLNQDQIVLEVKIKTRRKDITIPRKVIASSRFAVEF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TXHM1_HERML
Sequence: GCIPYGKTCEFWSGPWCCAGKCKLNVWSMTLSCTRNF
What is the function of this protein?
Blocks the Nav1. 2/SCN2A, Nav1. 4/SCN4A, and Nav1. 6/SCN8A sodium channels.  Reduces the peak amplitude of the sodium current and negatively shifts the steady-state inactivation process.  Does not shift the threshold potential of activation or the voltage corresponding to maximal current.  Does not change the reversal potential of the sodium current.  May act on site 1 of the receptor.
What are the official names of this protein?
Mu-thomitoxin-Hme1a, Mu-TMTX-Hme1a, Neurotoxin Hm-1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 01 (U2-agtx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: END8_ENT38
Sequence: MPEGPEIRRAADSLEAAIKGKPLTNAWFAFPQLKSFESSLIGQKVTQIETRGKALLTHFSHNLTLYSHNQLYGVWRVVDAGEHPQTSRILRVRLQTADKAILLYSASDIEMLTPEQLLTHPFLQRVGPDVLDMRLTAEEVKARLLSPKFRNRQFSGLLLDQAFLAGLGNYLRVEILWEVGLAAQRKASQLSEEQLDALSHALLEIPRLSYNTRGVVDDNKHHGALFRFKVFHREGKACERCGGVIERSTLSSRPFYGCPVCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: MNMA_BACHK
Sequence: MNKLPHETRVVIGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYNDVIEVCNQIGIPYYAVNFEKQYWDKVFTYFLDEYRAGRTPNPDVMCNKEIKFKAFLEHAIALGADYVATGHYARVAYMDGEYKMLRGVDDNKDQTYFLNQLSQEQLSKTMFPLGELKKPQIREMAKEAGLATAAKKDSTGICFIGERNFKDFLSNYLPAQPGVMQTLSGEVKGKHDGLMYYTIGQRHGLGIGGNGDPWFAVGKNLKENILYVDQGFHNELLYGDEVIATNVGWVSNEAKEKEFKCTAKFRYRQEDNKVTVQIVDENTVRILCDEPIRAITPGQAVVFYDGDECLGGATIDEVYRSGKKLDYLG
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMI2_MOUSE
Sequence: MAAAASESLSSGGPGAVRLPRLPPLKVLAGQLRRHAEGGPGAWRLSRAAVGRAPLELVAVWMQGTVLAAEGGQARLRDSSGAFSVRGLERVPRGRPCLLPGKYVMVMGVVQACSPEPCLQAVKMTDLSDNPVHESMWELEVEDLHRNIP
What is the function of this protein?
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates.  It is required to regulate sister chromatid segregation and to limit DNA crossover.  Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM.  In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
What are the official names of this protein?
RecQ-mediated genome instability protein 2.
What is the protein family that this protein belongs to?
Belongs to the RMI2 family.
What are the subcellular locations of this protein?
Nucleus. Note=Colocalizes with BLM at nuclear DNA repair foci.
Protein: GPHA2_MOUSE
Sequence: MPMAPRVLLLCLLGLAVTEGHSPETAIPGCHLHPFNVTVRSDRLGTCQGSHVAQACVGHCESSAFPSRYSVLVASGYRHNITSSSQCCTISSLRKVRVWLQCVGNQRGELEIFTARACQCDMCRFSRY
What is the function of this protein?
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production.  Plays a central role in controlling thyroid cell metabolism.
What are the official names of this protein?
Glycoprotein hormone alpha-2, Putative secreted protein Zsig51, Thyrostimulin subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit alpha family.
What are the subcellular locations of this protein?
Secreted.
Protein: STAD3_ARATH
Sequence: MSMALLLTSPAMKQKPAVITSPRRGSSPSRRLRVSCVTTNPARKKNETCNHFRPIKEVNNQLTHTIPQEKLEIFKSMENWAEQKLLPYLKPVEDSWQPQDFLPAPENDDEFYDRVKEIRERTKEIPDDYFVVLVGDMITEEALPTYQTTLNTLDGVKDETGGSLSPWAVWIRAWTAEENRHGDLLNKYLYLTGRVDMRHVEKTIQYLIGSGMDSKFENNPYNGFIYTSFQERATFISHGNTARLATTYGDVTLAKICGTIAADEKRHETAYTKIVEKLFEIDPDGSVQALASMMKKRITMPAHLMHDGRDNDLFDHYAAVAQRIGVYTAADYAGILEFLLRRWKVESLGLGLSGEGRRAQEYLCTLPQRIKRLEERANDRVKLVSKPSVSFSWVFGRDVKL
What is the function of this protein?
Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain.  Also able to convert palmitoyl-ACP to palmitoleoyl-ACP at the C9 position.  Exhibits delta-9 palmitoyl-[acyl-carrier-protein] desaturase (PAD) activity.  Involved in omega-7 monounsaturated fatty acid biosynthesis, especially in the endosperm oil (PubMed:27681170).
What are the official names of this protein?
Stearoyl-[acyl-carrier-protein] 9-desaturase 3, chloroplastic, Stearoyl-ACP desaturase 3, Acyl-[acyl-carrier-protein] desaturase 3.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL25_PSYIN
Sequence: MSIKLTATTRTDLGKGASRRLRHADLVPAIVYGADKEAVSLTFTHKDIIKAEGIEAFYSSVLDLEIDGVSEQVVLKDLQRHAFKARIQHLDLLRVDAKHKLHTTVPLHFINEGLSEAIKNGGIVYRTINEVEVLCLPKDLPSFIEVDISTMEIGDTLHLSNITLPAGVESVELNKGEEHDLPMVSIALSKKAPAEEIEAETAE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: PDRP_DESHD
Sequence: MTKEMPVIYIISDALGETAEYVSRAAAAQFSGIRTKIRKVPYVQDEIHIDEILEEAAKEQAIIAYTLVVKKLRNYLEEKAKDYGLRTVDILGPLIKMLADQTGLLPSYTPNVTHILDEQYFRKVDAIEFAVKYDDGKDPRGVLLADVVLIGVSRTSKTPLSMYLAHKGIKAANIPLVPEVSPPQELFRVPSQKVIGLTLKPDLLNQIRTERLRTLGLGSSADYANYERIVEELEYARGIMRKVGCPIIDATGKAIEETASRILEILYKGERNV
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: HELI_GAHVM
Sequence: MSQESNDLFCEATYLNFTAMHGIQSIITRVRALADATLSDELIPPLSYFIEASNHENPVELEARDLPFAVYLISGNAGSGKSTCIQTLSEILDCIITGTTKVASQNIYCKLSNSYTSPHINTIFQEFGFKGNHVQANLGKWQYVCSTSPPTMKELQKKDIVYYWEVLSDITKSMLKVLDSETGPGKFDVIRTLEDLLGKPRGNLSWMTFGIHGSLPSFTRSNIIIIDEAGLLGKYLLTAIVYCWWLTNAVYRTPQYKRGLKPVLICVGSPTQTSSLESTFEHSKLRCNVRISENILTYIICNQTLRSYLDLSNNWAIFINNKRCTEPEFGDLLKTLEYGLPITEEHARMADNFVVPEAFINNPANLPGWTRLYSSHKEVSTYMSRLHDYLKTSGNNKFVVFTLPAYTFISLENFERYRTAANQPHITLEKWLNVNAGRLSNWSQSRDQDATQTRCEIRSQQGLAISCSDITYVLNSQVAVTTRLRKWVFGFCGTFENFLSVLKDDSFIKTHGEGSIEYAYRFLSHLLFNGMINFYNYLQQRSLSEHAVKTAYNKLATLTNTILFPQRQLSAGDGENFNDVIVPTDLCHFEGKGIEDVDIQQRHENVDDVIFSALDDQMIDLLYCNYEFGHAETSSEIYTQFSMLKTMFMGRYSIMVELFGRNFSTSRFDSYVDNVSSRGCEIFINNMRGGMLSLALQTDSYTLMGYTFARVNAFADEPIRRKIQPHVAEVLGELNMPTIVLKDQHGFMAAVNSNINDFVESVDDHELKMAVTADYGISSKLAMTIARSQGLSLERVAICFAHSGLKLSSVYVAMSRVTSSKYLRMNINPLRETHSRDDNNISEHLLAALRDPKVHIVY
What is the function of this protein?
Component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase synthesizes short RNA primers on the lagging strand that the polymerase elongates using dNTPs.  Possesses helicase-like motifs and therefore may act as the helicase subunit of the complex.
What are the official names of this protein?
DNA replication helicase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae helicase family.
What are the subcellular locations of this protein?
Host nucleus.