PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_NEIM0
Sequence: MAIANNKKAFHDFFIEDRIEAGLVLEGWEVKAIRAARVQLKESYIYWKKDAFYLVGCHITALPTASTHIKPDAVRPRKLLLNQSEINKLIGKTERAGYTIVPLDLHFSRGKIKMEIGLAKGKKQHDKRQSMKEADWKREKQRLIKHTR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MSHR_MOUSE
Sequence: MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:1325670).  The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1325670).  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TDRD5_XENLA
Sequence: MEQERIMQRVQKDVRSLLIASKNGLSIQELEQDYRMMIGSQIPLRSLGYKSTMELLLDMPNVVQIHTQMDGTVNLSAVVDEATRKIADLVSCQKDRSTARSRNRRRNIRPRCPVDLVRRGRVSPVLPATVKSDLRDLLSLSPLLLSELEKAFFSRFGRSFQYTRYGFYSMLEVLRSISDIVEVKQTRTGSLLVLRKSETGHISASLCVKKSLDCQPAAVPNKTSCVFEKCLNEPQRPEKKPSEPATSLKISPPEFQKFSSQEPQSITSSRSFLHSSSNKEPDVNRNVSLGESKKSIENKTSPAVPSNNVVLNNSLVKNSETFESLFTRMSKPVSHVEADHANASEPNSSDLNWLEKKLEKELKLCLARKGAGGSVSDDLRSDIKHVVNQHSNGLNISLLPTAFKSFTGKDLPFKELGFMSVMELVGSLGDILCLESTDEGKDWKLFGAKKEDLVDEFSAGLRSTNSSLSSWNSTRQSTAPLKPVGTIFSKVDEKLWWGPLELKVCSTEQIDIPPDAVRNQKLHCLPRIKHSLMIGVYVESIESPSQFYVRCCGKDTSEKLEDMMIEMRHCYSNECVSERYIVPDNCISVGQIYALRVPGDVWWYRVIVHSIKNSELLDVFYPDFGNVATVKKSWLRFLKNCYMKVPAQAVPSSLPFVTSTEAQWSTQAIKRFRQLCSCLPLVGLVLQYVQDVLVIFLCDTSSAEDVYLHQLLIAQGLAKMEPEHACKKVSRNTFMHYLTPSQEKPQEESSKSSVPSESSQSEVLCTKETILQVIDEVDPEMPYLEAFPTDTDVWDENWVFSDGAGGSNTTPTIPKVETQKQENKISKEQKQPFKFCMDSGDASVVHRPLEEFYISLIKSSKSQESTDIQQSSHTEEQHLAEKSHRCTAEQLQGGSSSSMLCEKKLYYENKDLTYCQQQSKCSFSPLIGFQKLQIPRSATPAALGPAARLATAGRLLYWASDSH
What is the function of this protein?
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity.  Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity).
What are the official names of this protein?
Tudor domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the TDRD5 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.
Protein: ZFP10_ARATH
Sequence: MEKPGGFWIPKKSNKESSWEELAFAEDDAAGSLWPPRSYTCSFCRREFKSAQALGGHMNVHRRDRARLKQADDQYLFPKSSSSPEYPSHKDSDNIHETSCYTLVFNTKPNYFKTQHSCVIDLSSSSSLPYLTPSRVSSGLPGKQHTSSSPPSFVVEPSKNSKYIPSSSPWSCPSTVVEQKSCDLYEIPAMEGEKKRKTESDVPKIGHKAKLSLGNTTDLSVSMNLVIHQSFPITAHGSDEEIGRVDIRKRRRRHESPSQQSIFISSLSCKSDIITRNEESKHKGDRFEDLDLELRLGTDPPKGI
What is the function of this protein?
Probable transcription factor that may regulate cell division and growth.
What are the official names of this protein?
Zinc finger protein 10, AtZFP10.
What are the subcellular locations of this protein?
Nucleus.
Protein: METJ_SALG2
Sequence: MAEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMREMGIDPETWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAMYB_ORYSJ
Sequence: MYRVKSESDCDMIHQEQMDSPVADDGSSGGSPHRGGGPPLKKGPWTSAEDAILVDYVKKHGEGNWNAVQKNTGLFRCGKSCRLRWANHLRPNLKKGAFTAEEERLIIQLHSKMGNKWARMAAHLPGRTDNEIKNYWNTRIKRCQRAGLPIYPTSVCNQSSNEDQQCSSDFDCGENLSNDLLNANGLYLPDFTCDNFIANSEALPYAPHLSAVSISNLLGQSFASKSCSFMDQVNQTGMLKQSDGVLPGLSDTINGVISSVDQFSNDSEKLKQAVGFDYLHEANSTSKIIAPFGGALNGSHAFLNGNFSASRPTSGPLKMELPSLQDTESDPNSWLKYTVAPALQPTELVDPYLQSPAATPSVKSECASPRNSGLLEELIHEAQTLRSGKNQQTSVISSSSSVGTPCNTTVLSPEFDMCQEYWEEQHPGPFLNDCAPFSGNSFTESTPPVSAASPDIFQLSKVSPAQSTSMGSGEQVMGPKYEPGDTSPHPENFRPDALFSGNTADPSVFNNAIAMLLGNDLSIDCRPVLGDGIMFNSSSWSNMPHACEMSEFK
What is the function of this protein?
Transcriptional activator of gibberellin-dependent alpha-amylase expression in aleurone cells.  Involved in pollen and floral organs development.  May bind to the 5'-TAACAAA-3' box of alpha-amylase promoter.  Required for anther development (PubMed:19454733, PubMed:20590996).  Functions in parallel with UDT1 to regulate early anther development.  Functions upstream of the transcription factor TDR and may positively regulate its transcription (PubMed:20590996).  Required for pollen development.  Probably required for controlling tapetal cell size and promoting tapetal programmed cell death (PCD) during anther development.  Required for exine and Ubisch body formation in anthers.  Interacts with the DNA specific motifs of giberrellin-up-regulated genes of anthers and regulates their expression.  Positively regulates the expression of the laurate hydroxylase CYP703A3, known to be essential for the development of pollen exine and anther epicuticular layer (PubMed:19454733).  Functions with MYBS1 to integrate diverse nutrient starvation and gibberellin (GA) signaling pathways during germination of grains.  Sugar, nitrogen and phosphate starvation signals converge and interconnect with GA to promote the co-nuclear import of GAMYB and MYBS1, resulting in the expression of a large set of GA-inducible hydrolases, transporters and regulators that are essential for mobilization of nutrient reserves in the endosperm to support seedling growth (PubMed:22773748).
What are the official names of this protein?
Transcription factor GAMYB, OsGAMyb.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBQ2_ARATH
Sequence: MAQAVTSMAGLRGASQAVLEGSLQINGSNRLNISRVSVGSQRTGLVIRAQQNVSVPESSRRSVIGLVAAGLAGGSFVKAVFAEAIPIKVGGPPLPSGGLPGTDNSDQARDFSLALKDRFYIQPLSPTEAAARAKDSAKEIINVKSFIDKKAWPYVQNDLRLRASYLRYDLNTVISAKPKEEKQSLKDLTAKLFQTIDNLDYAARSKSSPDAEKYYSETVSSLNNVLAKLG
What is the function of this protein?
Required for photosystem II assembly/stability and photoautotrophic growth under low light conditions.
What are the official names of this protein?
Oxygen-evolving enhancer protein 3-2, chloroplastic, OEE3, 16 kDa subunit of oxygen evolving system of photosystem II, OEC 16 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the psbQ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Associated with the photosystem II complex.
Protein: CO5_MOUSE
Sequence: MGLWGILCLLIFLDKTWGQEQTYVISAPKILRVGSSENVVIQVHGYTEAFDATLSLKSYPDKKVTFSSGYVNLSPENKFQNAALLTLQPNQVPREESPVSHVYLEVVSKHFSKSKKIPITYNNGILFIHTDKPVYTPDQSVKIRVYSLGDDLKPAKRETVLTFIDPEGSEVDIVEENDYTGIISFPDFKIPSNPKYGVWTIKANYKKDFTTTGTAYFEIKEYVLPRFSVSIELERTFIGYKNFKNFEITVKARYFYNKVVPDAEVYAFFGLREDIKDEEKQMMHKATQAAKLVDGVAQISFDSETAVKELSYNSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLSPYTLNLVATPLFVKPGIPFSIKAQVKDSLEQAVGGVPVTLMAQTVDVNQETSDLETKRSITHDTDGVAVFVLNLPSNVTVLKFEIRTDDPELPEENQASKEYEAVAYSSLSQSYIYIAWTENYKPMLVGEYLNIMVTPKSPYIDKITHYNYLILSKGKIVQYGTREKLFSSTYQNINIPVTQNMVPSARLLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPDEYVYSPGQTVSLDMVTEADSWVALSAVDRAVYKVQGNAKRAMQRVFQALDEKSDLGCGAGGGHDNADVFHLAGLTFLTNANADDSHYRDDSCKEILRSKRNLHLLRQKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIANKIRKESPHKPVQLGRIHIKTLLPVMKADIRSYFPESWLWEIHRVPKRKQLQVTLPDSLTTWEIQGIGISDNGICVADTLKAKVFKEVFLEMNIPYSVVRGEQIQLKGTVYNYMTSGTKFCVKMSAVEGICTSGSSAASLHTSRPSRCVFQRIEGSSSHLVTFTLLPLEIGLHSINFSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIRGIVNRRKEFPYRIPLDLVPKTKVERILSVKGLLVGEFLSTVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLEAGNHWNIFYPDTLSKRQSLEKKIKQGVVSVMSYRNADYSYSMWKGASASTWLTAFALRVLGQVAKYVKQDENSICNSLLWLVEKCQLENGSFKENSQYLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDICPTMKIHTALDKADSFLLENTLPSKSTFTLAIVAYALSLGDRTHPRFRLIVSALRKEAFVKGDPPIYRYWRDTLKRPDSSVPSSGTAGMVETTAYALLASLKLKDMNYANPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLLKQIHLDMDINVAYKHEGDFHKYKVTEKHFLGRPVEVSLNDDLVVSTGYSSGLATVYVKTVVHKISVSEEFCSFYLKIDTQDIEASSHFRLSDSGFKRIIACASYKPSKEESTSGSSHAVMDISLPTGIGANEEDLRALVEGVDQLLTDYQIKDGHVILQLNSIPSRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISDTRLQKVCEGAACTCVEADCAQLQAEVDLAISADSRKEKACKPETAYAYKVRITSATEENVFVKYTATLLVTYKTGEAADENSEVTFIKKMSCTNANLVKGKQYLIMGKEVLQIKHNFSFKYIYPLDSSTWIEYWPTDTTCPSCQAFVENLNNFAEDLFLNSCE
What is the function of this protein?
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.  Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes.  C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
What are the official names of this protein?
Complement C5, Hemolytic complement.
What are the subcellular locations of this protein?
Secreted.
Protein: MDH_VIBC1
Sequence: MKVAVIGAAGGIGQALALLLKNRLPAGSDLALYDIAPVTPGVAADLSHIPTPVSIKGYAGEDPTPALEGADVVLISAGVARKPGMDRADLFNVNAGIVKSLAEKIAVVCPTACVGIITNPVNTTVPIAAEVLKKAGVYDKRKLFGVTTLDVIRSETFVAELKDKDPGDVRVPVIGGHSGVTILPLLSQVEGVEFTAEEVEALTKRIQNAGTEVVEAKAGGGSATLSMGQAACRFGLALVRALQGEEGVVECAYVEGDSEHASYFAQPVKLGKDGVEEVLSYGALSDYEKSALDGMLETLNGDINIGVEFAK
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Protein: QSOX2_XENLA
Sequence: MAAFVGLPLRSVPMLLLLLLLVVAGTARGETLYGPEDSVTILNKESVARAVFNSSSAWLLEFYSSWCGHCINYAPTWKALARDVRDWEPAIKIGVLDCAEEDNYGACKDFGVTLYPTFRFFKAFTKEFTQGENYKAVGDREIQTVRQVIIDFLQTSPAESKPQAWPSLEPISSSEISSLLTPKQSHYTAIIFESEESYEGREVILDLIQYSNIVVRRALPSDKPILEKLGIGSVPSCYLIQPNGLHGLINDVKSIRSQLSLHLKALSNVRKLLPSETAHSGLSKGVQQEDTTMNQFDRSKLYMTDLESGLHYILRAELANHHTLEGEKLKTFKDFVTILYKLFPGRPHVMKLLETLQEWLVSMPLDTIPYDAILDLVNNKMRISGIFLTNHTQWVGCRGSKSNLRGYPCSLWKLFHSLTVQAAVKPDALANTAFEAEPRAVLQTMRRYIREFFGCRECAKHFEAMAKETVDSVKTPDQAILWLWRKHNVVNNRLSGAPSEDPKFPKVQWPTSDLCSACHSQTGGVHSWNEDEVLAFLKRYYGNQEISLEFADPRKDLSEAATDNGNKEPHFTKKPQERDYVKKQNPQFLDKLVQKKPEKSLDSEAAESSQSVSFLGIGFSNIDMSLCVILYVTSSLFLMIMFFFFRFRSKRWKVRYNRPFV
What is the function of this protein?
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.  May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).
What are the official names of this protein?
Sulfhydryl oxidase 2, Quiescin Q6-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: U239_DROME
Sequence: MSASADSLGAAAALDKYGDEDIFSLLIRYGLYVGALFQFVCISAAVLMENNPDGQSNPESGEVTEREGEPVRTRLHKIRKLEKKKRR
What are the official names of this protein?
Protein anon-73B1.
What is the protein family that this protein belongs to?
Belongs to the UPF0239 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GCSH_SYNWW
Sequence: MKIPADLYYSPSHEWVRVEGDQAWIGISDYAQHELGDIVFVEMPEPDDELEAGGQLGVIESVKAASTIYSPVGGTVVAINEELEDAPQLINEDPYANYIVVVAMNNPGDLDNLLSAAAYEELCQKEQGGE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: ASND1_DANRE
Sequence: MCGICCVVSLTTQHNPLEENVHKNLKHRGPNCSKDITEEISNCSVLFSAHVLHMRGCLTPQPLQDDTGNMLLWNGEVFGGLKLEQEENDTEVLLHQLSMATSASDIVCLLSQLEGPWAFIYYQKSERCIWFGRDFFGRRSLLWKFNPERASFTLASVASQPADDSQSQWQEVPPGGVYRFDLTDTSLDGTFIFELYPWIFHSDDKPIESPELKCEGLPRCVSVNTNSSGLYLTSPVCPMNTSISSLTTEQNHNASQTSVENLKAFLTNTDKKAMVSALIDVLSEAVRKRVQYLPARDALEVSLNQTKADIAILFSGGIDSMILAALTDRHVPADKPIDLLNVAFKMQEAKMPPKSMKKGKNKKNDCDDADKTQLDQQKFNPFNVPDRITGRAGLQELKNLSPKRQWNFIEINVTQEELVEMRQKRICHLVHPLDTVLDDSLGCAIWFAARGIGVINEAVDEELYISEAKVVLTGIGADEQLAGYSRHRVRYKHSGLEGLVRELAMELGRISSRNLGRDDRIIGDHGKEARFPYLDEDVVSFLNGLPVSEKADLSLPRGVGEKLLLRLAAVELGLGLSALLPKRAMQFGSRIAKLEDNHEKASDKCKRLVTTI
What are the official names of this protein?
Asparagine synthetase domain-containing protein 1.
Protein: RNFH_SALDC
Sequence: MPDKLVVEVAYALPEKQYLQRVTLEEGATVEEAIRASGLLELRTDIDLAKNKVGIYSRPVKLTDTVQDGDRVEIYRPLIADPKALRRQRAEKSAGR
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: GGLO6_ARATH
Sequence: MAFTSSPSYGSLNAAFWRTIFVVHCISTLVFTTISTPPEDPVKCVSGNTNCTVTNSYGAFPDRSTCRAANVAYPTTEAELISVVAAATKAGRKMRVTTRYSHSITKLACTDGTDGLLISTKFLNHTVRTDATAMTLTVESGVTLRQLIAEAAKVGLALPYAPYWWGLTVGGMMGTGAHGSSLWGKGSAVHDYVTEIRIVSPGSVNDGFAKVRVLRETTTPKEFNAAKVSLGVLGVISQVTLKLQPMFKRSLRYVMRNDSDFGDQAVTFGMKHEFADFIWLPSQGKVVYRMDDRVAVNTSGNGLLDFMPFRSQLSAALAIIRSSEETQERFRDANGKCAGATLITSTLFATSYGLTNNGMIFTGYPVIGSQNRMMSSGSCLDSLHDGLITACPWDSRIKSEFFHQTTFSIPLTQVKSFINDIKSLVKIESKSLCVLELYDGILMRYVTSSPAYLGKETEALDFDLTYYRAKDPLSPRLYEDFIEEIEQIALFKYNALPHWGKNRNLAFDGVIKKYKNVPAFLKVKESYDPMGLFSSEWTDQILGIKGNVTIIKDGCALEGLCVCSEDAHCAPTKGYFCRPGKVYKEARVCTRADDISVIQSLSY
What is the function of this protein?
May be involved in the biosynthesis of ascorbic acid.
What are the official names of this protein?
Probable L-gulonolactone oxidase 6, AtGulLO6.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: DCAM2_ARATH
Sequence: MAMSAIGFEGYEKRLEVTFFEPGLFLDTQGKGLRALAKSQIDEILQPAECTIVSSLSNDQLDSYVLSESSLFIFPYKIVIKTCGTTKLLLSIEPLLRLAGELSLDVKAVRYTRGSFLCPGGQPFPHRNFSEEVSVLDGHFAKLGLSSVAYLMGNDDETKKWHVYSASSANSNNKNNVYTLEMCMTGLDKDKASVFYKNESSSAGSMTDNSGIRKILPQSQICDFEFEPCGYSMNSIEGDAISTIHVTPEDGFSYASFEAVGYDFTTMDLSHLVSKVLTCFKPKQFSVAVHSTVAQKSYDSGLSVDLDDYGCKESTMESLGEERGTVMYQRFEKLGRYCGSPRSTLKCEWSSNSSCNSEDEKE
What is the function of this protein?
Essential for biosynthesis of the polyamines spermidine and spermine.  Essential for polyamine homeostasis, and normal plant embryogenesis, growth and development.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme 2, AdoMetDC2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic AdoMetDC family.
Protein: DERL1_PONAB
Sequence: MSDIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFYFPVGPGTGFLYLVNLYFLYHYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ
What is the function of this protein?
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins.  Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane.  This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome.  The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first.  May mediate the interaction between VCP and the misfolded protein.  Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation.  By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
What are the official names of this protein?
Derlin-1, Der1-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the derlin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CINA_NATTJ
Sequence: MIGEIISVGDELLEGHVLNTNSQYLSQQLFQIGINVKYQQTIGDDFDSLVSAFNNSLNRSDVIILTGGLGPTRDDITKEAVSRSLNLNLLLDENEYQRIKSFFDHLQKRMSENNKKQAYIPEGAEVLINQIGTAPGIFIEQEDKIVAMLPGPPREMKTVFLNELKPRLIKNITAEGYYKSSIIKLIGIGESQVDEIIKEIKIPNCEIVPLALRHQVHLILKSYSQNQITAEEQLKRLENMLQHKLSSFIWGRDDDKLEEIVVNTLKDKGLSLAVAESMTGGLIAGKLTDVSGASNVFHGGVVAYTEDAKLNSLTVSQKVLEKYSHVSEETSYELAKQIREKFNTDIGLGITGYAGPEGERVGLFHTVIVGSTGKRHLSRILPGGRTDIKKGAVIQSLNELRKFLSD
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: BRB_AMOLO
Sequence: MFTLKKSLLLLFFLGTINLSLCEQERDADEEERRDDDEMDVEVEKRFLPLAVSLAANFLPKLFCKITKKC
What is the function of this protein?
Antimicrobial peptide with activity against Gram-positive and Gram-negative bacteria and against fungi (PubMed:17000029).  Has been tested against S. aureus (MIC=5. 5 ug/mL), E. coli (MIC=6. 5 ug/mL), B. dysenteriae (MIC=2. 2 ug/mL), and C. albicans (MIC=7. 5 ug/mL) (PubMed:17000029).  Can regulate or mediate antimicrobial response by stimulating mast cell degranulation (PubMed:17000029).  Induces histamine release (PubMed:17000029).  Shows cytotoxicity toward solid tumor cell line HepG2 (PubMed:17000029).  Also shows a potent hemolytic activity (LD(50)=5 ug/ml) (PubMed:17000029).
What are the official names of this protein?
Brevinin-ALb, Amolopin-1b, Brevinin-1E-AL2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TUS_SALPC
Sequence: MSRYDLVERLNGTFRQIEQHLAALTDNLQQHSLLIARVFSLPQVTKEAEHAPLDTIEVTQHLGKEAETLALRHYRHLFIQQQSENRSSKAAVRLPGVLCYQVDNAIQLDLENQIQRINQLKTTFEQMVTVESGLPSAARFEWVHRHLPGLITLNAYRTLTLINNPATIRFGWANKHIIKNLSRDEVLSQLKKSLASPRSVPPWTREQWQFKLEREYQDIAALPQQARLKIKRPVKVQPIARIWYKGQQKQVQHACPTPIIALINTDNGAGVPDIGGLENYDADNIQHRFKPQAQPLRLIIPRLHLYVAD
What is the function of this protein?
Trans-acting protein required for termination of DNA replication.  Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks.  The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
What are the official names of this protein?
DNA replication terminus site-binding protein, Ter-binding protein.
What is the protein family that this protein belongs to?
Belongs to the Tus family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_STRP2
Sequence: MTSPLLESRRQLRKCAFQALMSLEFGTDVETACRFAYTHDREDTDVQLPAFLIDLVSGVQAKKEELDKQITQHLKAGWTIERLTLVERNLLRLGVFEITSFDTPQLVAVNEAIELAKDFSDQKSARFINGLLSQFVTEEQ
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: STT3_DICDI
Sequence: MKRSEKSSTSVVSNNKQQDVNIISSNEVGVKEENKGHQEFLLKVLILSVIYVLAFSTRLFSVLRYESVIHEFDPYFNYRSTIYLVQEGFYNFLNWFDERAWYPLGRIVGGTIYPGLMATASLVHWSLNSLNITVNIRNVCVLLSPWFASNTAMVTYKFAKEVKDTQTGLVAAAMIAIVPGYISRSVAGSFDNEGIAIFALIFTYYCWIKSVNTGSLMWAAICSLAYFYMASAWGGYVFIINLIPLHAFFLLLTGRYSHRLYIAYSTMFVIGTILSMQITFISFQPVQSSEHLAAIGIFGLLQLYAGLSWVKSHLTNEAFKKLQRLTVLFVLSCAAAVLVVGTLTGYISPFNGRFYSLLDPTYARDHIPIIASVSEHQPTTWASYFFDLHILVFLFPAGLYFCFQKLTDANIFLILYGVTSIYFSGVMVRLMLVLAPVACILAAVAVSATLTTYMKKLKAPSSPSDANNSKESGGVMVAVLTVLLILYAFHCTWVTSEAYSSPSIVLSAKQNDGSRVIFDDFREAYRWIGQNTADDARIMSWWDYGYQLSAMANRTVLVDNNTWNNSHIAQVGKAFASTEEDAYIQMKALDVDYVLVIFGGLTGYSSDDINKFLWMVRIGGSCDPNIKEQDYLTNGQYRIDKGASPTMLNSLMYKLSYYRFSEVHTDYQRPTGFDRVRNVEIGNKNFDLTYLEEAFTSVHWLVRVYKVKDFDNRA
What is the function of this protein?
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.  This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3, Oligosaccharyl transferase subunit STT3.
What is the protein family that this protein belongs to?
Belongs to the STT3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MURG_FINM2
Sequence: MNIIVSGGGTGGHIYPAISLIEELKKRDKDNKILYVGTEKGLESSIVPKLGIDFKTIHVRGIPRKINANSFKALKELFQGLREANKILKEFKPDLVIGTGGYVSGPILYKATKTKAKVAFHEQNSFPGITNRILSRYVDKYFVTFKESIKYFKNQDKAVVTGNPIRNRFTDIEKNKKSALEQYDISENKKVVFIFGGSNGSEILNKATLNMIEKISNQDKFEIVLATGKLNYDEFIQQSGKEIKNLHVYPYIDDIDKAYAVSDLIVTSSGAITLAELSFLGKASILVPKAYTTENHQEHNARAFEKNGASKVILEKDLNSDTLFDQINEILSDDNLLNELSENSKKMSYPTACKDIVDELYRLVEQDEKA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y3927_SHEPW
Sequence: MLDTKFDELMEFPASFPFKVVGDASDTLQDRVVAVVQGLAPGDYAPSTKASSKGTYYSVTIRVTVTSKEQIEKLYTQLAELEGVKRVL
What are the official names of this protein?
UPF0250 protein swp_3927.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.