PharMolix/UniProtQA huggingface dataset:
Protein: SIA10_RAT
Sequence: MKGYVVAIFLSSIFLYYVLYCILWGTNGYWFPNEEMKSKNNVKNCFKKPAFASLLRFPQFYPFLCKADFVKVAATYGTNNFLLPYGVKTFESYFRSGLSKLQSCDLVGQFDTVPCKRCVVVGNGGVLKNKTLGAKIDSYDVIIRMNNGPVLGHEEEVGKRTTFRLFYPESVFSDPSHYDPNTTAVLVVFKPQDLRWLMEILIGKKINTDGFWKKPALKLIYKQYQIRILDPYIIREAAFQLLRFPRVFPKDQKPKHPTTGIIALTLAFHICSEVHLAGFKYNFYTPDSPLHYYGNATMSLMKKNAYHNLTAEQLFLKNLIKKKMVINLTQN
What is the function of this protein?
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant.  Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids.  Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity).
What are the official names of this protein?
Type 2 lactosamine alpha-2,3-sialyltransferase, CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI, ST3Gal VI, ST3GalVI, Sialyltransferase 10.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: SYA_BRUA4
Sequence: MAGVNEIRSTFLDYYRKNGHEVVPSSPLVPRNDPTLMFTNAGMVQFKNVFTGLEHRSYNRATTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKEDAISFAWNLITKEFGLPKDKLLVTVYHTDDDAANYWKKIAGLSDDRIIRIATSDNFWAMGDTGPCGPCSEIFFDHGDHIWGGPPGSADEDGDRFIEIWNLVFMQFEQITPEQRIDLPRPSIDTGMGLERVAAVLQGVHDNYDIDLFKALIRASEEATGVKAEGEFRASHRVIADHLRASSFLIADGVLPSNEGRGYVLRRIMRRAMRHAQLLGAKEPLMWRLLPALIREMGQAYPELIRADALISETLKLEETRFRKTLDRGLGLLSDATESLVEGDRLDGETAFKLYDTYGFPLDLTQDALRQRGIAVDTDGFSAAMQRQKAEARANWAGSGEAATETIWFGIKDKVGATEFLGYETEVAEGVITALVRDGAEVQSAAEGDVVSVVVNQTPFYGESGGQQGDTGTISGEGFAIAIKDTQKKGEGVFVHIGEVTKGTAKTGDAVELKVDSVRRTRIRSNHSATHLLHEALRETLGSHVAQKGSLVAPDRLRFDFSHPKPISAEELTQVENLANEIILQNAPVSTRLMAVDDAIAEGAMALFGEKYGDEVRVVSMGTAKHGSKEGKAYSVELCGGTHVRQTGDIGLVRIVSEGAVAAGVRRMEALTGEAARLYLEEQDERVKAIAGALKTTPSEALERVNALLDERKKLERELADARKKLALGGGSADGGSAVEAVNGVNFLGKIVTGVSPRDLKPLADEGKKQVGSGVVLFIGIGEDSKASAVAAVTEDLVGRFSAVDLVRAASVALGGAGGGGRPDMAQAGGPDGDKADAAIAAVKALII
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_NEIM0
Sequence: MFDKHVKTFQYGNHTVTLETGEIARQAAAAVKVSMGDTVVLVAVTTNKEVKEGQDFFPLTVDYLERTYAAGKIPGGFFKREGKQSEKEILTSRLIDRPIRPLFPEGFYHDIQIVAMVVSVDPEIDSDIPAMLGASAALVLSGVPFAGPIGAARVGYINGVYVLNPTKAELAKSQLDLVVAGTSKAVLMVESEAKILPEDVMLGAVVYGHDQMQAAINAINEFADEVNPEVWDWKAPETNEELVAKVRGIAGETIKEAFKIRQKQARSAKLDEAWNAVKEALITEETDTLAANEIKGIFKHLEADVVRSQILDGQPRIDGRDTRTVRPLNIQTGVLPRTHGSALFTRGETQALAVATLGTSRDEQIIDALSGEYTDRFMLHYNFPPYSTGEVGRVGAPKRREIGHGRLAKRALLAVLPKPEDFSYTMRVVSEITESNGSSSMASVCGGCLSLLSAGVPLKAHVAGIAMGLILEGNKFAVLTDILGDEDHLGDMDFKVAGTTEGVTALQMDIKIQGITKEIMQIALAQAKEARLHILDQMKAAVAGPQELSAHAPRLFTMKINQDKIREVIGKGGETIRSITAETGTEINIAEDGTITIAATTQEAGDAAKKRIEQITAEVEVGKVYEGTVVKILDNNVGAIVSVMPGKDGLVHISQIAHERVRNVGDYLQVGQVVNVKALEVDDRGRVRLSIKALLDAPAREENAAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASCL1_MOUSE
Sequence: MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAQSAQQQQPQAPPQQAPQLSPVADSQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
What is the function of this protein?
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:24243019).  Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes (PubMed:20107439, PubMed:24243019, PubMed:27281220).  The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220).  Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS (PubMed:8217843).  Essential for the generation of olfactory and autonomic neurons (PubMed:8221886).  Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation (PubMed:16020526, PubMed:17728344).  Involved in the regulation of neuroendocrine cell development in the glandular stomach (PubMed:18173746).
What are the official names of this protein?
Achaete-scute homolog 1, ASH-1, mASH-1, mASH1.
What are the subcellular locations of this protein?
Nucleus.
Protein: NFI_ECOHS
Sequence: MDLASLRAQQIELASSVIREDRLDKDPPDLIAGADVGFEQGGEVTRAAMVLLKYPSLELVEYKVARIATTMPYIPGFLSFREYPALLAAWEMLSQKPDLVFVDGHGISHPRRLGVASHFGLMVDVPTIGVAKKRLCGKFEPLSSEPGALAPLMDKGEQLAWVWRSKARCNPLFIATGHRVSVDSALAWVQRCMKGYRLPEPTRWADAVASERPAFVRYTANQP
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDRP_LACCB
Sequence: MTQELNLYIMSDSVGETGLRLAQAVAAQFPNFEAHYVRFPFIHTEEKIYSALDEAKKENALAIMTFVTSGFAQLATHYAKDQGVIAIDVMSPILSGIKSITHEEPNHVPGAVHDLNERYFDRISAMEFAVLYDDGKDPKGFLEADIVLLGVSRTSKTPLSLFLANRNLKVANLPLVPNAHIPEEIWSVDPKKIVGLTTDASVLMEFRRQRMIAYGLNPDTAYSARDQVNQELKFAEDLYKKIGCMVINTAHRSIEETATLILEHMGLDEFDNTETH
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: MOAA_ALKOO
Sequence: MKDLYSRRINYMRISITDLCNLRCQYCMPAEGICKKDHKEVLTLEEITDIVKAGVGLGIDKVRITGGEPLVRNGIVEFIQMISNIDGIKDIAITTNGILLPRYAEALKEAGLKRVNISIDSLNPDKYREITRGGDLSKVLEGINECIRLGLTPVKLNVVAIGGYNDDEIEDFIQLTMDKPIDVRFIELMPIGEASQWGKDRFISNEEIVHRFKNLVPMETEKSSPAKYYQLPGGMGRVGLINPISSHFCGDCNRVRLTSDGKLKPCLHSNHEIDILDAVRNHPEKIQEVLASAILSKPEKHDLLTDSHEESNRGMSQIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: ATG15_YEAST
Sequence: MLHKSPSRKRFASPLHLGCILTLTVLCLIAYYFALPDYLSVGKSSSRGAMDQKSDGTFRLKSIYRHGVGANHRLHQRLEVTPEVISAAGMLYQETTTQGQDFEDQEPLWTTNAEYATTNPFDFEFELRRMPLLMKRMKERDPEFIESYIYGETYMTEEEEHAMWIDDDIVAPNITDRGTVVSLALMSSNAYVRIPQTGDWRNVTEPWNETEPEDFGWDGDGIRGHVFYNEVENIVVLSIKGTSAQGLPGSGEDETTGNDKINDNLLFSCCCARVSYLWTTVCDCYVKSYICDESCLEKELRRKDRFYSAVVDIYKGVLKEYPDAAIWVTGHSLGGALASLLGRTFGLPAVAFESPGELLPSKRLHLPFPPGLPSYMEGIWHFGHNADPIFMGTCNGASSSCSLVGYAMETACHTGRVCVYDVVNDKGWSVNMFNHRIHKVIDEVLLGYEQAAKCVEPEPCVDCYNWKFIPSRDWESSSRLITKTKSHAAPTTTTRTTATTTSSSTCVGRNWLGFCTKYEL
What is the function of this protein?
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies.  Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles.  The intravacuolar membrane disintegration by ATG15 is critical to life span extension.
What are the official names of this protein?
Putative lipase ATG15, Autophagy-related protein 15, Cytoplasm to vacuole targeting protein 17.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Single-pass type II membrane protein. Prevacuolar compartment membrane; Single-pass type II membrane protein. Note=From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Protein: CH602_RHOPS
Sequence: MAAKDVKFAGDARDRMLRGVDILANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEIELEDKFENMGAQMLREVASKTNDLAGDGTTTATVLAQAIVREGAKSVAAGMNPMDLRRGIEIAVAAVIKDIGKRAKPVASSAEIAQVGTISANGDAPIGKMIAQAMQKVGNEGVITVEENKSLDTEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDVYILLHEKKVSGLQSMLPVLEAVVQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQLISEELGVKLESVTLKMLGRAKKVVIDKENTTIVNGAGKKADIEARVQQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVEDALNATRAAVQEGIVPGGGVALLRAKKAVGRINNDNADVQAGINIVLKALEAPIRQIAENAGVEGSIVVGKILENKSETFGFDAQTEEYVDMLAKGIVDPAKVVRTALQDAASVAALLVTTEAMVAELPREAAPAMPGGGGMGGMGGMGGMGF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KXD1_YEAS7
Sequence: MVTGISEENDDEETFSAVHSSTPSINSQSYAIPITEEMSSSFHDSISTTSNSSGSFDSDGSNVSDVVEQNEMDNESNVDEDLFLDNDIPQSSNLLPTDAQDPGPIFDVSRYIFDSLKQSIDSADFSEALSLQTKTSAVINSKSLELKQYIDEMKSRLTQLQEKFENGEATSKKIKRDLETSRKNIDYLNAALRVDFPIEFNQAREKILERRLNEDHDC
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit KXD1, BLOC-1 subunit KXD1, KxDL homolog.
What is the protein family that this protein belongs to?
Belongs to the KXD1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: STT3A_ARATH
Sequence: MAALESPLPGTPTAMRNAFGNVLSVLILVLIGVLAFSIRLFSVIKYESVIHEFDPYFNYRVTQFLSKNGIYEFWNWFDDRTWYPLGRVIGGTVYPGLTLTAGTIWWGLNSLNIPLSVETVCVFTAPVFSAFASWATYLLTKEVKGSGAGLAAAALLAMVPSYISRSVAGSYDNEAVAIFALIFTFYLYIKTLNTGSLFYATLNALAYFYMVCSWGGYTFIINLIPMHVLLCIVTGRYSPRLYIAYAPLVVLGTLLAALVPVVGFNAVLTSEHFASFLVFIIIHVVALVYYIKGILSPKMFKVAVTLVVSIGMVVCFIVVAILVALVASSPTGGWSGRSLSLLDPTYASKYIPIIASVSEHQPPTWPSYFMDINVLAFLVPAGIIACFSPLSDASSFVVLYIVMSVYFSGVMVRLMLVLAPAACIMSGIALSQAFDVFTGSIKYQLGASSNSTDDAEDNTSTNNAPKDDVSAGKTDKGEEIVKERSSKKGKKKEREPADKPSVKAKIKKKALVLPLEASIVALLLLIMLGAFYVIHCVWAAAEAYSAPSIVLTSQSRDGLHVFDDFRESYAWLSHNTDVDDKVASWWDYGYQTTAMANRTVIVDNNTWNNTHIATVGTAMSSPEKAAWEIFNSLDVKYVLVVFGGLIGYPSDDINKFLWMVRIGGGVFPHIKEADYLRDGQYRIDSEATPTMLNSLMYKLSYYRFVETDGKGYDRVRRTEIGKKHFKLTHFEEVFTSHHWMVRLYKLKPPRNRIRGKAKKLKSKTSSGLSSKSAKKNPWV
What is the function of this protein?
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.  This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity).  Controls adaptive responses to salt/osmotic stress.  Acts as a key glycosylation determinant for EFR function during plant innate immunity (PubMed:12972670, PubMed:19763086, PubMed:19763087).
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, Oligosaccharyl transferase subunit STT3A, STT3-A, Integral membrane protein 1, Protein STAUROSPORIN AND TEMPERATURE SENSITIVE 3-LIKE A.
What is the protein family that this protein belongs to?
Belongs to the STT3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VP40_MABVM
Sequence: MASSSNYNTYMQYLNPPPYADHGANQLIPADQLSNQQGITPNYVGDLNLDDQFKGNVCHAFTLEAIIDISAYNERTVKGVPAWLPLGIMSNFEYPLAHTVAALLTGSYTITQFTHNGQKFVRVNRLGTGIPAHPLRMLREGNQAFIQNMVIPRNFSTNQFTYNLTNLVLSVQKLPDDAWRPSKDKLIGNTMHPAVSIHPNLPPIVLPTVKKQAYRQHKNPNNGPLLAISGILHQLRVEKVPEKTSLFRISLPADMFSVKEGMMKKRGENSPVVYFQAPENFPLNGFNNRQVVLAYANPTLSAV
What is the function of this protein?
Plays an essential role virus particle assembly and budding (PubMed:33673144).  Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway.  The interaction with host E3 ubiquitin ligase SMURF2 facilitates virus budding (PubMed:33673144).  The interaction with the nucleocapsid and the plasma membrane may also facilitate virus budding.  Specific interactions with membrane-associated GP and VP24 during the budding process may also occur (By similarity).  May play a role in genome replication (By similarity).
What are the official names of this protein?
Matrix protein VP40, Marburg VP40, mVP40, Membrane-associated protein VP40.
What is the protein family that this protein belongs to?
Belongs to the filoviridae matrix protein VP40 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein. Host late endosome membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Host endomembrane system; Peripheral membrane protein. Note=In virion, localizes on the intravirional side of the membrane. In the host cell, it is found associated with virus-induced membrane proliferation foci and probably also in multivesicular bodies. These VP40-enriched membrane clusters are then redistributed to the plasma membrane where budding takes place.
Protein: RIMM_METCA
Sequence: MPGNSGNDRSVVVGRVSGAFGVRGWVKAVSFTDPPVNLVGYRPWTLRRGDAERRADVLEGREHGNAVIVRLQGVDTREQAEALKGFEVTVRRSQLPPPAPGEYYRVDLVGLKVVNLGETVLGEVVDVMETGANDVLVVQGDRERLLPFVQGVFVKSVNLEESRIVVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFA3_THRS2
Sequence: MALRVKTNKKPCWEMTKEELTSGKTEVFNYEELLEFAEGDIGKVFGPEFAPIDKYSRRVRLPAREYLLVTRVTLMDAEPNNYRVGARMVTEYDLPVNGELSEGGDCPWAVLVESGQCDLMLISYMGIDFQCQGDRVYRLLNTTLTFYGVAHEGETLEYDIRVTGFAKRLDGGISMFFFEYDCYVNGRLLIEMRDGCAGFFTNEELAAGKGVVFTRADLAARAKVAKQDISPYAVAPCLHKTTLSEKEMQTLVDKDWASVFGSKNGMPEINYKLCARKMLMIDRVPKIDHTGGIYGLGLIVGEKILERDHWYFPCHFVKDEVMAGSLVSDGCSQMLKMYMIWLGLHLTTGPFDFRPVSGHPNKVRCRGQISPHKGKLVYVMEIKEIGFDEKNDPYAIADVNIIDIDYEKGQTFEMSRLGDYGKGDLNKKIVVDFKGIALKMQKRSTSTEEPSKVVPVFAKGQATVGTEASRAPGAATAYSPDVLAPAPVALPKNLLKGDPLAPREMTWHPMARIPGNPTPSFAPSAYAPRNIAFTPFPGNPLDNDHTPGKMPLTWFNMAEFMAGKVSQCLGPEFTKFDNSNTSRSPAWDLALVTRAVSVTDMEHVKWRNIDCNPSKGTMIGEFDCPADAWFYKGAANDGHMPYSILMEIALQTSGVLTSVLKAPLTMEKDDILFRNLDANADFVRADVDFRGKTIRNITKCTGYSMLGEMGVHRFSFELSVDDVVFYKGTTSFGWFVPEVFAAQAGLDSGRKSEPWFVEQKVPAGQVVSYDVRPGASGRTSLFANAPSGAQLNRRTNQGQYLDKIDLVSGSGKQGLGYGHGVKAVNPNDWFFACHFWFDSVMPGSLGVESMFQLVEAIAVQDDLAGKHGIANPTITHAPGKISWKYRGQLTPKSKQMDSEVHVTSIEAHDGVVDVVADGYLWADGLRVYQVNNIRVRIASGEPAASSSASSVGSSASAEVAERTRSKAAPQPVASGPAQSINLEQLKTDLLELDAPLYLSQDPTTGQLKKHTDVASGQATIVQPCTLGDLGDRSFMETYGVVAPLYTGAMAKGIASADLVIAAGKRKILGSFGAGGLPMHLVREAVDKIQAALPQGPYAVNLIHSPFDSNLEKGNVDLFLEKGVTVVEASAFMTLTPQVVRYRAAGLSRNADGSVRIRNRIIGKVSRTELAEMFIRPAPEHLLEKLIASGEITQEQAELARRVPVADDIAVEADSGGHTDNRPIHVILPLIINLRNRLHRECGYPASLRVRVGAGGGVGCPQAAAAALSMGAAFIVTGTVNQVCKQSGTCDNVRKALSKASYSDICMAPAADMFEEGVKLQVLKKGTMFPSRANKLYELFCKYDSFESMPPNELERVEKRIFQRALAEVWQETKDFYINRLHNPEKIQRAERDPKLKMSLCFRWYLGLASFWANAGIADRVMDYQVWCGPAIGAFNDFIKGTYLDPEVSGEYPCVVQVNLQILRGACYLRRLNALRNDPRIDLETEDAAFVYEPTGSL
What is the function of this protein?
Polyketide synthase-like protein; part of the polyunsaturated fatty acid synthase composed of the 3 PKS-like subunits A, B and C (PubMed:27527703).  While the saturated fatty acids (SFAs) in Thraustochytrium are produced by the conventional fatty acid synthase (FAS) pathway, polyunsaturated fatty acids (PUFAs) including docosahexeanoic acid (DHA) and docosapentaenoic acid (DPA) are synthesized via an anaerobical PKS pathway (PubMed:27527703).  PUFA synthase assimilates fatty acyl-CoA, the product of FAS, as the starter unit to synthesize DPA, and this starter unit may be butyryl-CoA, hexanoyl-CoA, or octanoyl-CoA (By similarity).  DPA and DHA biosynthesis seem to differ by the reduction at the N-3 position by PUFA synthase, not the extension of carbon chain (By similarity).  In DHA biosynthesis, PUFA synthase extends the fatty acyl chain from the methyl toward the carboxyl end, and the double bond is formed when the carbon chain is growing, instead of afterward (By similarity).  Therefore, PUFA synthase is unable to transform DPA to DHA, suggesting that DPA is not the precursor of DHA (By similarity).  Moreover, DPA molecule is partly extended by FAS KS domain, so DPA biosynthesis is less dependent on PUFA synthase KS domain than DHA (By similarity).
What are the official names of this protein?
Polyunsaturated fatty acid synthase subunit C, PUFAs-C.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
Protein: NDUF5_PONAB
Sequence: MLRPAGLWRLCRLSWAARVPAENLGRRDVTSGVSPRGSTSPRTLNIFDRDLKRKQKNWAAQQPEPTKFDYLKEEVGSRIADRVYDIPRNFPLALDLGCGRGYIAQYLNKETIGKFFQADIAENALKNSLETEIPTVSVLADEEFLPFRENTFDLVVSSLSLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLQGMGESNCSWNRKALLHRDTMLAAAAVYREMYRNEDGSVPATYQIYYMIGWKYHESQARPAERGSATVSFGELGKINNLMPQGNKSQ
What is the function of this protein?
Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages.  Acts by mediating hydroxylation of 'Arg-111' of NDUFS7.  May also have methyltransferase activity.
What are the official names of this protein?
Arginine-hydroxylase NDUFAF5, mitochondrial, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5, Putative methyltransferase NDUFAF5.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane.
Protein: ARCD_LATSK
Sequence: MTEEKPAKKIGLLALIALVISSSIGSGVFGLTSDLASASAPGPVLIAWVIVGFGILMLALSLNNLLMKEPELEGIFSYAEKGFGPFAGFISGWGYWLSAWLGNVTFATILMSALGYFFPIFKSRQNLPSILVASVLSWSLTYFVNRGVEGAAAINTLVTICKLIPLFVFIIFGIVLFKGHLFTQAFWNNMSSSFVAGDVMSQIKNCMMVMMWVFVGIEGASMLSARAEKKSDAGKATILGLVSLLAIYILASVLPYGYLTQDQLASIKQPAMLYIFEQMVGTWGGYFIGVGLIISILGAWLSWTMLPAETMLLMAKQNLLPAYFGRVNKKKAPTFALVVTAGLIQVFLFTLLFTTKAYNFAYSLCTASIIVCYMLVAAYQIKYSWAHLQEKGNRQQLLIGVLALLFEIAGILMAGVSYLLLCFIAYIPGIYFYGRARKNNGHQHFLSKGEWLITTIIVIGAIIGIWLVVSGKIVI
What is the function of this protein?
Catalyzes electroneutral exchange between L-arginine and L-ornithine.
What are the official names of this protein?
Arginine/ornithine antiporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ENPP5_RAT
Sequence: MIPEFLVVSCTLAALCHSVPLSLQTEQQKVLVVSFDGFRWDYLYKVPTPHFHYVMKNGVHVKQVTNVFITKTYPNHYTLVTGLFAENHGIVANDMFDPVLNKSFSLEHMNIYDSKFWEEATPLWITNQRAGHASGAAMWPGTDVKIHESYPTHYLPYNESVSFEDRVAKIIEWFTAKDPINLGFLYWEEPDDTGHDVGPDSPLMGPVISDIDHKLGYLIKMLKKAKLWNNINLIVTSDHGMTQCSKERVIELDQYLDKEHYTLIDHSPVAAILPKEGKFNEVYDALANAHPNLTVYKKEEIPERWHYKHSDRVQPIVAVADEGWYILQNKSDEFLLGNHGYDNALAEMHPIFLAHGPAFRKNFTKEAMNSTDLYSLVCHLLNVTALPHNGSFRNVQDLLSSAAPKAIPYTQSTTLPLGSAKPGEYEQEESYPYYIGISLGSLIAIVFFVVLIKHLIRSQMHTLQYMQVEVAQPLLQA
What is the function of this protein?
Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates (By similarity).  May play a role in neuronal cell communication.  Lacks nucleotide pyrophosphatase and lysopholipase D activity in vitro (PubMed:12927778).
What are the official names of this protein?
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5, E-NPP 5, NPP-5.
What is the protein family that this protein belongs to?
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RPOZ_MYCTA
Sequence: MSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQINDYYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLLEHTEGE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: ELDP2_LOTGI
Sequence: MMQTLLRGLCVVVLFWGYIKASADFDCRRTSQTCVTGTCDDVSGSCVCPTDAGGSPSHTNKDCGLELAKVASPATLCDPPCLNGGQCFEPTADTYMCMCSEAFYGSQCENPRKQVECSGDQITINYMPIPTFSGDIFILDNRNTPECAFTEANGMYTATFTYQQCGVITTNDQPNVGDTSYQTSAAVRFNANIERGTDMKLTAECVIDGSGQSNLNNNIGTVSVDQRSNLTEETALTQYQPVSFQLQGKNGNPMPVPVNLGDELRIYIPLADTGKYTKLKITDLTTNNGMAAPDMVTETLIFNGCLTDIGEALVTGDISSDPAIPAIIINFMAFRLRGSPQVKFEAKVKVCEAADTSCEPGSCPTPAPPAPVQPTPSENPGRKRRAASDNEVILHETLTVLDPRSNEKLRLPHNKSDKKSQQNADPQQCLQSTEIMVMVIVLIVAVVLLLVITTCLAVKFMKQRAAQVKIYNSDMPTGNNTVRIPHSAF
What are the official names of this protein?
EGF-like domain-containing protein 2, Uncharacterized shell protein 24, LUSP-24.