PharMolix/UniProtQA huggingface dataset:
Protein: MAPE_PINMG
Sequence: MTCTLRLTVAALVLLGICHLSRPVAAYQKCARYWYCWLPYDIERDRYDDGYRLCCYCRNAWTPWQCREDEQFERLRCGSRYYTLCCYTEDDNGNGNGNGNGYGNGNGNGNGNNYLKYLFGGNGNGNGEFWEEYIDERYDK
What is the function of this protein?
May be specifically involved in the formation of the nacreous layer.
What are the official names of this protein?
Perlin matrix protein.
What is the protein family that this protein belongs to?
Belongs to the N16 matrix protein family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: CSLB1_ARATH
Sequence: MADSSFSLPPLCERISYTNYFLRAVYLTVLGLFFSLLLHRIRHTSEYDNVWLVAFFCESCFFLVCLLITCLKWSPADTKPFPDRLDERVHDLPSVDMFVPTADPVREPPIMVVDTVLSLLAVNYPANKLACYVSDDGCSPLTYFSLKEASKFAKIWVPFCKKYNTRVRAPSRYFLKPISVATEDYEFNRDWEKTKREYEKLRRKVEDATGDSHMLDVEDDFEAFSNTKPNDHSTLVKVVWENKGGVGDEKEIPHIIYISREKRPNYVHNQKCGAMNFLARVSGLMTNAPYILNVDCDMYANDADVVRQAMCILLQESLNMKHCAFVQFRQEFYDSSTELIVVLQSHLGRGIAGIQGPIYIGSGCVHTRRVMYGLSPDDFEVDGSLSSVATREFLVKDSLARRFGNSKEMMKSVVDAIQRNPNPQNILTNSIEAAREVGHCQYEYQTSWGNTIGWLYDSVAEDLNTSIGIHSRGWTSSYISPDTPAFLGSMPAGVPEALLQQRRWATGWIEILFNKQSPLRGLFSKKIRFRQRLAYLCIITCLRSIPELIYCLLPAYCLLHNSTLFPKGLYLGITVTLVGIHCLYTLWEFMSLGYSVQSWLVSQSVWRIVATSSWLFSIFDITLKLLGISETVFIITKKTVAGTKSALGSGPSQGEDVGPNSDLFKFEFDGSLCFLPGTFIVLVNIAALAVFSVGLQRSSYSHEGGGSGLAEACGCVLVMMLFLPFLMGLFKKGKYGTPLSTLSIAGFLAVLFVVFSV
What is the function of this protein?
Thought to be a Golgi-localized beta-glycan synthase that polymerize the backbones of noncellulosic polysaccharides (hemicelluloses) of plant cell wall.
What are the official names of this protein?
Cellulose synthase-like protein B1, AtCslB1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like B subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: ALA2_HORVU
Sequence: MAATVAVDNLNPKVLKCEYAVRGEIVIHAQRLQEQLKTQPGSLPFDEILYCNIGNPQSLGQQPVTFFREVLALCDHPDLLQREEIKTLFSADSISRAKQILAMIPGRATGAYSHSQGIKGLRDAIASGIASRDGFPANADDIFLTDGASPGVHLMMQLLIRNEKDGILVPIPQYPLYSASIALHGGALVPYYLNESTGWGLETSDVKKQLEDARSRGINVRALVVINPGNPTGQVLAEENQYDIVKFCKNEGLVLLADEVYQENIYVDNKKFHSFKKIVRSLGYGEEDLPLVSYQSVSKGYYGECGKRGGYFEITGFSAPVREQIYKIASVNLCSNITGQILASLVMNPPKASDESYASYKAEKDGILASLARRAKALEHAFNKLEGITCNEAEGAMYVFPQICLPQKAIEAAKAANKAPDAFYALRLLESTGIVVVPGSGFGQVPGTWHFRCTILPQEDKIPAVISRFTVFHEAFMSEYRD
What is the function of this protein?
Transfer of C3 units between the cytosol of mesophyll and bundle sheath cells to maintain a nitrogen-carbon balance in the C4-dicarboxylic pathway.
What are the official names of this protein?
Alanine aminotransferase 2, ALAAT-2, Glutamate pyruvate transaminase 2, GPT, Glutamic--alanine transaminase 2, Glutamic--pyruvic transaminase 2.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
Protein: TXF1A_SCOMO
Sequence: MKMNVVVLSVVVLLLFIANIQQTEAGKPEKEVNFPAPGKKPTREDCKKACANKYTNGVMSKVIVAKLTGKNCYCKYQEN
What are the official names of this protein?
U-scoloptoxin(15)-Sm1a, U-SLPTX(15)-Sm1a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-15 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMC_SALCH
Sequence: MQCALYDAGRCRSCQWITQSVNEQLSAKTADLHRLLAGLPVEQWCAPIGGPEQHFRNKAKMVVSGSVEKPLFGMLHRDGTPVDLCGCPLYPASFAPVFSALKPFIARAGLTPYNVARKRGELKYLLLTESQFDGGMMLRFVLRSETKLTQLRAALPWLRAQLPQLRVITANIQPVHMAIMEGETEIYLTDQQALVERFNDVPLWIRPQSFFQTNPTVASRLYATARDWVGQLPVRHMWDLFCGVGGFGLHCATPQMQLTGIEIAPEAIACAKQSAAELGLTRLHFQALDSTQFAIAQGETPDLVLVNPPRRGIGKPLCDYLAQMAPRFIIYSSCNAQTMAQDIRHLPNYRIQRVQLFDMFPHTAHYEVLALLRRSI
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: NAPEP_HUMAN
Sequence: MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVKLNEALERYGLNAEDFFVLKHGESRYLNNDDENF
What is the function of this protein?
D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:27571266, PubMed:25684574).  Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity).  May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity).  As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight.  In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose.  Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity).
What are the official names of this protein?
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-PLD, NAPE-hydrolyzing phospholipase D.
What is the protein family that this protein belongs to?
Belongs to the NAPE-PLD family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Nucleus envelope. Nucleus, nucleoplasm. Note=Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids.
Protein: THIG_CAMJD
Sequence: MQENLKNDKLKIGKYEFDSRFILGSGKYSLELIKSSIEEAKAQIITLALRRANTGEIANILDYIPKNITLLPNTSGARNADEALRIARLSRELGCGELIKIEVISDSRYLLPDNYETIKACELLAKEGFTPLPYMHADLYAARAMRDVGAAAIMPLAAPIGSNKGLCAKEFIQILLNEIDLPIIVDAGIGTPAQACEAMQMGVSAVMVNTAIAEAKDIALMARAFSLAVNAGRAAFLAGLASVSEAKASSPLTGFLRD
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MACB_ACIAD
Sequence: MMTKQALLEVHNLVREFPAGDSTVQILKNINLTIYEGELVAIVGQSGSGKSTLMNILGCLDRPTSGSYKVSGQETGKLEPDDLAKLRREYFGFIFQRYHLLGDLSAEGNVEVPAVYAGVTPAERKQRATALLTELGLGSKTENRPSQLSGGQQQRVSIARALMNGGDVILADEPTGALDSHSGVEVMRILRELNAAGHTVIIVTHDMQVAKNATRIIEISDGKIIADRENIPEYASELNKDPDAAPAIANKQSKGKSVSAFRSMLDRLSEAFQMALISMNAHRMRTFLTMLGIIIGIASVVTVVALGNGSQKQILENISSLGTNTITVFQGRGFGDNSKTANFKTLVPSDADALSSQPYVTAVSPMVSSSKTIRYKENEATATINGVSNDYFDVKGLTFKDGQSFDQRSVRDLTQDVVIDTNTQKQFFTDGSNPIGQVVLLGSVPARIIGIVEPQTSSMGSDDSLNVYMPYTTVMSRMLGQSNVRNIIVRINDQYSTSAAENAIVNLLTLRHGQQDIFTMNSDSIRQTIEKTTSTMTLLVSAIAVISLIVGGIGVMNIMLVSVTERTQEIGVRMAVGARQSDILQQFLIEAILVCLIGGVLGVLLSLGLGQLINKVAAGNFAVAYSTTSIVAAFVCSTLIGVVFGFLPARNAAQLDPVAALSRE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMH_AFIC5
Sequence: MSAAVSRHISVLGREAVEFLAPRAGGIYVDATFGAGGYSRRILAVAGARVIGIDRDRTAIAEAFDLVEQAEGRLTLVQDRFSQLDEVCASQNAPQVDGIVMDIGVSSMQLDRAERGFSFRQDGPLDMRMGQEGASAADVVAVASEKDLANIIYIFGEERHSRAVARAIVRARQEKPILTTKVLADIVASVVHTRPNDIHPATRTFQALRIFVNEELDELQSALHASERTLKPGGRLVVVTFHSLEDRIVKNFINARASRGGGSRHMPDVERTAPSFEILTKRPVVADENEIAANPRARSAKLRAAERTANASHDADTSFDWPTLRTVMKGGRA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_BURO1
Sequence: MSMRTEYCGLVTEHLLGQTVSLCGWVQRRRDHGGVIFIDLRDREGLVQVVCDPDRAEMFATAEGVRNEFCVQIKGLVRNRPDGTVNAGLKSGRIEVLCHELNVLNASVTPPFQLDDDNLSETTRLTHRVLDLRRPQMQHNLRLRYRVAIEARKYLDEQGFIDIETPMLTKSTPEGARDYLVPSRVNAGQFFALPQSPQLFKQLLMVANFDRYYQITKCFRDEDLRADRQPEFTQIDCETSFLGEQEIRDLFEDMIRHIFKTTIDVELDAKFPVMPYSEAMARFGSDKPDLRVQLEFTELTDAMKDVDFKVFSTPANAKDGRVAALRVPKGGELSRGDIDGYTEFVRIYGAKGLAWIKVNEKAKGRDGLQSPIVKNLHDASIAAILERTGAEDGDIIFFAADRAKVVNDSLGALRLKIGHSEFGKANGLVQAGWKPLWVVDFPMFEYDDEDARYVAAHHPFTSPKDEHLEYLETDPGRCLAKAYDMVLNGWEIGGGSVRIHREEVQSKVFRALKIGAEEAQLKFGFLLDALQYGAPPHGGIAFGLDRIVTMMAGADSIRDVIAFPKTQRAQDLLTQAPSPVDERQLRELHIRLRQPEQPKA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
Protein: ARGA_YERE8
Sequence: MKERSTELVQGFRHSVPYINAHRGKTFVVMLGGEAIEHENFSSIVNDIGLLHSLGIRLVVVYGARPQIDSNLAQHHYEPVYHKHTRVTDARTLEMVKQAAGLLQLDITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGVDDGVDYCHSGRIRRIDEEAIHRQLDNGAIVLLGPVAVSVTGESFNLTSEEVATQLAIKLKAEKMIGFCSSQGVTDSEGNIISELFPNDAQKRIEDLEQEGDYNSGTVRFLRGAVKACRSGVRRSHLLSYQEDGALVQELFSRDGIGTQIVMESAEQVRRATINDIGGILELIRPLEQQGILVRRSREQLEMEIDKFTIIERDNLTIACAALYPFPEEQIGEMACVAVHPDYRSSSRGEMLLKRVANQARQMGLKKLFVLTTRSIHWFQERGFTPAEVDVLPIQKQELYNYQRRSKILLADL
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLK4_DROSE
Sequence: MLSNRAFGETIEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTSRVRQEVEIHSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARHFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRSSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHSAPGALNMFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQVLPQIREEFKQVHHKLPYEQPGLFGQASTGLAEPNWTGAAKTSAFRMETGMVPNSKPASLKEDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPPDLQIPSGDCVYNYDNLPNKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMETMTDSEIRFYSGAKLLKAPTEGLKVYDRNGMLLSDHSCSESRSLIEHGNECFTHCVNISNALEVAQTKDNSCFPVTIGRRPITDVQPAQRLDGLRDTTNITFSTPKSNQGSINFSLSTISSTRNTSDFGTNCSRSNMLAAHQNIPIKRINVPDIGIATELSHGVVQVQFYDGSVVSVIPSMQGGGITYTQPNGTSTHFGKDDDLPFPVRDRVGQIPNIQLKLKTAPLLGSGRKTDYNNAMTPKTTTPYYNRMLL
What is the function of this protein?
Serine/threonine-protein kinase that plays a central role in centriole duplication.  Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as sas-6.  When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase.  Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase PLK4, Polo-like kinase 4, PLK-4, Serine/threonine-protein kinase SAK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: TRX1_EHV1V
Sequence: MNLGGNRFVQIGNGMSNIMYTDANGAVRWEQISPPAGFPQQQRGRGRGHVAFGLPNTLDWLPGFVQATPNSITISNMGGIQISSAGVITAAINSEQNSWMLSSFNPSLKLTRQVTLTDFCDPTAERPGLPIIRLRHHLDAIGSSPSSTPPGRNPQELDEAWAALSELSVSGRSDTTGLRPSLLSLTFLVASRSGEYSDKAAAEAVRAHVLANYRDRRTEQRLDRFGEYLQAMVRTHVFPHKHMTVFGGLISHVIQDKLASLTAVAGGVQEGARTNNSAVPRSSVYVPACAFLDVDHELKLGDASAKFVYLIFVYSQRLRREGVRVYVAVSKFDEVAFEDAVSFLFHKARTESAIRGTEGADAPEPHPNAALPLQELSSSRCEPRCPPSRLNNREFTNALYQWAPDLRGRPNRTSCMYAAYIRLGAIASDPPRTTRRSERFGSVDMPVVWLENVRWDPQDWVECSY
What is the function of this protein?
Structural component of the T=16 icosahedral capsid.  The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes.  These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2.  Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.
What are the official names of this protein?
Triplex capsid protein 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRX1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RRP3_CHAGB
Sequence: MSAKRRKVSSGNGAIKEASIQIQKPKTKPQPVTAPVEPSAVPNSEAESETIDDASGEESEEPAPKTFQDLGIVDSLCDACKELGWKKPTPIQQESIPLALQDRDIIGLAETGSGKTGAFALPILQALLDKPQPLFALVLAPTRELAAQIAQSFEALGSLISLRCALILGGLDMVQQAIALGKKPHVVVATPGRLLDHLEKTKGFSLRNLRYLVMDEADRLLDMDFGPILDKILKFLPRERRTFLFSATMSSKVESLQRACLRDPLKVSISSSKYQTVSTLVQNYVFIPHTHKDTYLIYLCNEFAGQTIIIFTRTVIETQRIAILLRTLGMGAIPLHGGLSQSARLGALNKFRAGSRDILVATDVAARGLDIPNVDCVLNLDLPGDSKTYVHRVGRTARAGRSGHAISFVTQYDLELWLRIEAALGTKLTEYSLEKDDVMVFRPRVEEAQRIAKTEIKALMDDRGKKGSVLKGGKGRKRGPPGSSRDHMDAEEG
What is the function of this protein?
ATP-dependent rRNA helicase required for pre-ribosomal RNA processing.  Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent rRNA helicase RRP3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS6_SINFN
Sequence: MTLKARVIPCLDVKDGRVVKGVNFVDLIDAGDPVEAAKAYDAAGADELCFLDITASSDNRETIFDVVARTAEQCFMPLTVGGGVRQVSDIRKLLLAGADKVSINTAAVKNPEFVAEAADKFGNQCIVVAIDAKKVSAAGETDRWEIFTHGGRQPTGIDAIDFARKVVDLGAGEILLTSMDRDGTKSGYDIALTRAIADAVRAPVIASGGVGTLDHMVEGIRDGHATAVLAASIFHFGTYSIGEAKRYMAERGIAMRLD
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACADM_MACFA
Sequence: MAAAFGRCCRVLRSISRFHWRSQHTKADRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNPHIPQNCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNEQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKASWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVLKENVLIGDGAGFKIAMGAFDKTRPTVSSGAVGLAQRALDEATKYALERKTFGKLLIEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQIFGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIIAREHIGKYKS
What is the function of this protein?
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats.  The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA.  Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).  Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains.
What are the official names of this protein?
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, MCAD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GAT5A_XENLA
Sequence: MYPSLALTANHAQPAYSHDTPNFLHSTGSPPVYVPTSRMPAMLQSLPYLQSCDTAHQGHHLANHPGWAQTAESHAFNASSPHTPTGFSYSHSPPVGNSSARDGGYQSPLIMGGGARDQYGNTLVRTGSYPSPYSYVGADMPPSWAAGHFEGSMLHSLQGRQSLSGRRSSLEFLEEFPGEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPQKRLSSSRRAGLCCTNCHTSTTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKNIGKGKTSTGSSTSANNSPSSVTNSDPTPVLKTEPNITSQYSGQAIVPVSQGHSQTDDLVNGSHELKFMPDEYTYSPTALSQQSGLSVPLRQESWCALALA
What are the official names of this protein?
GATA-binding factor 5-A, Transcription factor xGATA-5A.
What are the subcellular locations of this protein?
Nucleus.
Protein: HEM3_XANOM
Sequence: MTTLRIATRKSPLALWQSEHVAAALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLFLKELELAMLRGDADCAVHSFKDVPMELDDPFVLPAILERGDPADALVSNLYASLQALPLGARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNGGYDAIVLACAGLQRLGLDERISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRACVEAERAMNRALHGSCHVPVAALARWEGEGLFLQGMVGSASDGRLIHADAHGSADDTEDLGRRVAQGLFDKGAAQLLAAL
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: DPH3_BOVIN
Sequence: MAVFHDEVEIEDFQYDEDSETYFYPCPCGDNFCITKEDLENGEDVATCPSCSLIIKVIYDKDQFTCGETVPAPSTNKELVKC
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase.  Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state.  Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM.  Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex.  The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
What are the official names of this protein?
Diphthamide biosynthesis protein 3, CSL-type zinc finger-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the DPH3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: POLG_GSMV
Sequence: TSPNINGFWVMLENDEQIEFPIKPLIDHARPTFRQIMSRFSDLAEAYIEKRNFERAYMPRYGLQRNLTDMSLRRYAFDFYEMTSKAPARA
What is the function of this protein?
Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the potyviridae genome polyprotein family.
What are the subcellular locations of this protein?
[Capsid protein]: Virion.
Protein: Y020_SULAC
Sequence: MNFIQEINGKISLNGNFAFILVIATTDVSLIPGITVAGATPELTHFTPAADAEFLIKEKCISINSVPVTPTGIPTPAIISRASLKLVNATKLVVNAGSRVKPKIPFIDVGGEPGGDIRKFSLTRETSQRILENSIILGEELANSYDFLVIGESIPAGTTTAMAVLLSLGYDAADKVSSASPVNPKDLKRKVVYEAIKDLPSDFLGKISKVSDPMLISVAGITIGFRKRVLLAGGTQMTAAAAIIKEIDKKIIQNISIGTTKWIIQDSSSDIVSISRQVGVPVMASLLDFSKSKYSGLRAYEEGFVKEGVGAGGSSIIALSKGFTPQDILVEIEKIYSKLI
What are the official names of this protein?
UPF0284 protein Saci_0020.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: ADA2B_ERIEU
Sequence: AIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSHCRGPRAKGAPGKGESKQTGQASLGAPSSAKLPNLVSRLVAAREANRHSKSTGEKVEGETPEGPGTPGVPPSWPPLPSSGRGQEEDIYRASPEEEAGDDEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLSRGVGTASGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPQHCKVPHGLF
What is the function of this protein?
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
What are the official names of this protein?
Alpha-2B adrenergic receptor, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor, Alpha-2BAR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane.
Protein: NEU2_MOUSE
Sequence: MLARMLNTTLSACFLSLLAFSSACYFQNCPRGGKRAISDMELRQCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAVGICCSDESCVAEPECHDGFFRLTRAREPSNATQLDGPARALLLRLVQLAGTRESVDSAKPRVY
What is the function of this protein?
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.  Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (By similarity).
What are the official names of this protein?
Vasopressin-neurophysin 2-copeptin, AVP-NPII.
What is the protein family that this protein belongs to?
Belongs to the vasopressin/oxytocin family.
What are the subcellular locations of this protein?
Secreted.