PharMolix/UniProtQA huggingface dataset:
Protein: Y2778_STAA8
Sequence: MTVLTDKVAVVTGAGSGIGEAIATLLHEEGAKVVLAGRNKEKLQNVANQLSQDSVKVVPTDVTNKEEVDELIKIAQQTFGGLDIVINSAGQMLSSKITDYQVDEWDSMIDVNIKGTLYTAQAALPTMLEQSSGHLINIASISGFEVTKSSTIYSATKAAVHTITQGLEKELAKTGVKVTSISPGMVDTAITAAYNPTDRKKLEPQDIAEAVLYALTQPKHVNVNEITVRPV
What are the official names of this protein?
Uncharacterized oxidoreductase SAOUHSC_02778.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: CYTC_RABIT
Sequence: MARSLGVPLLLLAALVVALALAVSPAAGARTRQSPRLLGGLEDVDAQEKDVQRALGFAESEYNKGSNDRYHSRALQVVRARRQIVSGVKYYLDVLIGRTTCTKTQTNLANCPFHDQPDLQRKMLCSFEIYSVPWLNKISLLKSDCQNA
What is the function of this protein?
This is a thiol proteinase inhibitor.
What are the official names of this protein?
Cystatin-C, Cystatin-3.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GGP_BACIE
Sequence: MHEIGEHLTTNTGWDIIKNRYEAAQAITEGSNFMIGNGFMGYRGTFAEDGKDAYAACIVTDTWDKADGKWEELSTVPNALLTLLHVDGEPFIMSEEAASFERTLDLSQGVTSRKVSQRMKNGATITIHEEKFASYRKKHAVLMKYTVESDQDTDAVLDTGIDYDVWSINGDHLQGHHYFSHPTGDGVTAKTVSYEDTVTVVETCSLDADASEEDYQNPDGSGRTFSLSLEAGKPVTLEKAMIIYSSNDVDNPQDEALLEAKHMQSYEEEKAANRLEWDNLWSHYDVTIQNNIIDQVALRFNIYHAIIATPVHKSLPIGARGLSCQAYQGAAFWDQEIYNMPMYLYSNPEIARNILKYRHRTLDGARRKAKRLGYEGAYYAWISGKTGDELCPDFFFKDVLSGRDIRNHFNDWQIHISPDIAYAVKKYHQVTGDDAFIRDYGAEMIFEIARFLASHAVYKPMRGRYEFMRVQGPDEYHENVDNNAFTNHQAMFTLQAADELLQTLDEKTLSAVKEKIGLSDDEISLWRDMLANTYVPKPDKHGIIEQFDGYYDLETIIPAKKVTERLIKEDEYYGYPNGVTVRTQCIKQADVIQLFVLHPHLYDRKTVELNYEFYEPRTLHFSSLSPSSYAIVAAQIDKVEEAYRNFRKSVMIDLLNTNEAVSGGTFIGGIHTAANGASWQMVVNGFGGLSVHGDDIHLSPRLPDAWDGYTFKAIVKGQTLEVDVTKEQITITNKSEDRKPLTLHIFGEKSVLDSERITKSR
What is the function of this protein?
Catalyzes both the (1) reversible phosphorolysis of 2-O-alpha-D-glucopyranosyl-sn-glycerol (GG) from beta-D-glucose 1-phosphate (betaGlc1P) and glycerol and (2) the hydrolysis of betaGlc1P.  the betaGlc1P hydrolysis is a glucosyl-transfer reaction to an acceptor water molecule that produces an anomer-inverted alpha-glucose, not a phosphatase-type reaction.  In the absence of glycerol produces alpha-D-glucopyranose and phosphate from beta-D-glucopyranose 1-phosphate.
What are the official names of this protein?
1,2-alpha-glucosylglycerol phosphorylase, 2-O-alpha-glucosylglycerol phosphorylase, GGP.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 65 family.
Protein: SRRB_STAAN
Sequence: MMSRLNSVVIKLWLTIILIVTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTSKNIRDSLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAVVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVLTNLIDNASRYTKPGDEIAITCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLPKPE
What is the function of this protein?
Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation.  Also plays an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate.  Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to SrrA.  In turn, SrrA binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression.
What are the official names of this protein?
Sensor protein SrrB, Staphylococcal respiratory response protein B.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NU4C_OENGL
Sequence: MNSFPWLTIIVVFPILTGSLIFLLPHRGNKVMKWYTLCICILELLLTTYTFCYHFQLDDPLTQLTENYKWIHFFDFYWRLGIDGLSIGPILLTGFITTLATLAAWPVTRDAQLFHFLMLAMYSGQIGSFSSRDLLLFFLMWEFELIPVYLLLSMWGGKKRLYSATKFILYTAGGSIFLLIGVLGIGLYGSNEPTLNFETLANQSYPVALEVIFYVGFLIAFAVKLPIIPFHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLVRINMELLPHAHCLFSPGLIIVGAIQIIYAASTSPGQLNLKKRIAYSSISHMGFIIIGIGSLSDTGLNGAILQIISHGFIGAALFFLAGTSYDRIRLLYLDEMGGMAIPLPKLFTMLSILSMASLALPGLSGFVAELLVFFGIITSQKYLLMPKILIAFLMAIGMILTPIYSLSMLRQMFYGYKLFNVPNYYFFDSGPRELFVSISLLLPIIGIGIYPDFVLSLSVEKVEAIISHFFFR
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RS19_ECOSM
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVTDEMVGHKLGEFAPTRTYRGHAADKKAKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: HIS1_XYLFT
Sequence: MSASTALPVRDRLRIAIQKSGRLTEPARRLLTACGLSWRQSRDKLFCYGESLPVDLLLVRDDDIPGLIAQGVCDLGIVGRNELDEQAASRRRNGLPVPYQTLRGLHFGQCRLMLAVPEEWEWQDISQLTGKRIATSYPAILADWLQTHHIAAQIVELSGSVEIAPRLGTADLICDLVSSGATLAAHQLKPVIQIMESQAVLAGMICQPADARAGLLAMLLRRIDGMVNLRDSNLLMFRAFQEHLDALTRLLPDADPLVQLPDDGSGTLRVQTMCHGTITWQRLEELERAGAQGLMVLTVERSLA
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPE58_MYCTU
Sequence: MHLMIPAEYISNVIYEGPRADSLYAADQRLRQLADSVRTTAESLNTTLDELHENWKGSSSEWMADAALRYLDWLSKHSRQILRTARVIESLVMAYEETLLRVVPPATIANNREEVRRLIASNVAGGKHSSNRRPRGTIRAVPGRKYPSNGPLSKLDPICAIEAAPMAGAAADPQERVGPRGRRGLAGQQQCRGRPGPSLRCSHDTPRFQMNQAFHTMVNMLLTCFACQEKPR
What are the official names of this protein?
Uncharacterized PPE family protein PPE58.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: IOVO_CALGM
Sequence: FAAVSVDCSEYPKPACTLEYRPLCGSDNKTYANKCNFCNAVVESNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: MA8I_SCHJA
Sequence: MCVRRVDILSRFDIALSLLQSLTHSHTVLRHLCFLPTIIYKHLCEFTISFSSPVISTGQHIDVGDEDYHDGDDDVDYTDDVDDVDDPHGSPSQLLQGGYQRNQHYGGGNYQSGYYRPNKQHGNGYGGQYPKKYGSGYKH
What are the official names of this protein?
Immunogenic miracidial antigen 8I.
What is the protein family that this protein belongs to?
Belongs to the immunogenic miracidial antigen family.
Protein: METC_RHIL3
Sequence: MKDKDSLLQNAGINTRLTHIGNDPFDYHGFINPPVVHASTVLFPNARAMETRTQKYTYGTRGTPTTDALCEAIDALEGSAGTILVPSGLAAVTIPFLGFVAAGDHALVVDSVYGPTRHFCDTMLKRLGVEVEYYHPEIGAGIETLFRSNTKLVHTEAPGSNTFEMQDIPAISAVAHRHGAVVMMDNTWATPVYFRPLDHGVDISIHASTKYPSGHSDILLGTVSANAEHWERLKEANGVLGICGAPDDAYQILRGLRTMGLRLERHYESALDIAKWLEGRDDVARVLHPALPSFPSHHLWKRDFKGASGIFSFVLAADGPEKSRAKAHAFLDALRIFGLGYSWGGFESLALHAYLNDRTVAKAPTDGPVIRLQIGIEDVADLKADIERGFAAASAV
What is the function of this protein?
Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis.
What are the official names of this protein?
Putative cystathionine beta-lyase, CBL, Beta-cystathionase, Cysteine lyase, Cysteine-S-conjugate beta-lyase, ORF5.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family.
Protein: NU6M_ARATH
Sequence: MILSVLSSLALVSGLMVVRAKNPVHSVLFFILVFCDTSGLLLLLGLDFFAMIFLVVYIGAIAVLFLFVVMMFHIQIAEIHEEVLRYLPVSGIIGLIFWWEMFFILDNESIPLLPTQRNTTSLRYTVYAGKVRSWTNLETLGNLLYTYYFVWFLVPSLILLVAMIGAIVLTMHRTTKVKRQDVFRRNAIDFRRTIMRRTTDPLTIY
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: MURA_WOLPM
Sequence: MHKILIRNNYKPLVGKIKINGSKNAVLPIMAASLLSSSSVILHNVPDLIDVHLMSKLLESLGAEVNFMHNKNYKANHTLKIDCSNINNHVMPYKTASKLRTSFLILGPMLSRFGKARTAFPGGCNIGKRPVDMHIKALEEMGAKIEIDGYNIIATVKGKLQGKEITFEKISVGATENVIMAATFAEGVTTINNAATEPEVLDLIDFLKKMGADIEIDNTKVIITGVEALNGCVHKIIPDRIEAGTYALAAIITGGKLELEGINLSDIRCITNELETIGAMVELYDGGIVISRKNGSIKSANVATDPYPNFPSDMQPQLMSAMCIADGISVIEENIFENRFTHADELRKLGANISIEKSKATISGIKSLSGANLYATDLRSTAALVLASLVAGGETIINNSHHLWRGYEAMHEKLNSCGADISISS
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: USHA_YERE8
Sequence: MRFSLSTTAAALAVSLAFAPGWAVAWEKDKTYDITILHTNDHHGHFWQNDHGEYGLAAQKTLVDDIRKQVAAAGGSLLLLSGGDINTGVPESDLQDAEPDFRGMNLVGYDAMAIGNHEFDNPLSVLRQQEKWATFPLLSANIYQKSTQQRLFKPYALFDKQGVKIAVIGLTTDDTAKIGNPEYFTDIEFRVPATEAKQVVEQLRKTEKPDIIIAATHMGHYDDGKHGSNAPGDVEMARSLPAGYLDMIVGGHSQDPVCMASENHKQADYVPGTPCAPDRQNGTWIVQAHEWGKYVGRADFKFRNGELKLVSYQLIPINLKKKVEKADGTSERIFYTQEIAQDPSMLKLLTPFEQQGKAQLDVKVGSVNGKLEGDRSKVRFEQTNLARLLLAAQMERAGADFAVMSGGGVRDSIDAGDITYKDVLKVQPFGNTLVYADMKGSEVEKYLAVVANKKVDSGAYAQFANVSLVADGKGVSNVKIQGKPLDPNKTYRLATLNFNALGGDGYPKIDTLPSYVNTGFIDAEVLKQYIEKHSPLDASQYQPKGEIVYK
What is the function of this protein?
Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell.
What are the official names of this protein?
Protein UshA.
What is the protein family that this protein belongs to?
Belongs to the 5'-nucleotidase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TXM14_MACGS
Sequence: MKILEKALLENDSAAEEESRNLRTKRCARKRAWCEKTENCCCPMKCIYAWYNGQSSCDHTISTIWTSCPK
What is the function of this protein?
Inhibits tetrodotoxin-sensitive sodium channels (Nav) (By similarity).  Intracranial injection into mice causes strong convulsions and death.  Intrathorax injection into crickets causes paralysis prolonged for 2 min, followed by recovery.
What are the official names of this protein?
Delta-hexatoxin-Mg1b, Delta-HXTX-Mg1b, Delta-atracotoxin-9, Neurotoxin magi-14.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 06 (delta-actx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: 3MG_RAT
Sequence: SKEPVSVVLPDAEHPAFPGRTRRPGNARAGSQVTGSREVGQMPAPLSRKIGQKKQQLAQSEQQQTPKEKLSSTPGLLRSIYFSSPEDRPARLGPEYFDQPAVTLARAFLGQVLVRRLADGTELRGRIVETEAYLGPEDEAAHSRGGRQTPRNRGMFMKPGTLYVYLIYGMYFCLNVSSQGAGACVLLRALEPLEGLETMRQLRNSLRKSTVGRSLKDRELCNGPSKLCQALARSKSFDQRDLAQDEAVWLEHGPLESSSPAVVAAAAGIGHAGEWTQKPLRFYVQGSPWVSVVDRVAEQMYQPQQTACSDXALIVQK
What is the function of this protein?
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
What are the official names of this protein?
DNA-3-methyladenine glycosylase, 3-alkyladenine DNA glycosylase, 3-methyladenine DNA glycosidase, ADPG, N-methylpurine-DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion matrix, mitochondrion nucleoid. Nucleus.
Protein: LEUC_METTH
Sequence: MSMTVSEKILARASGKDRVEAGEIVMADIDVAMTHDLTGPLSVESFRAIGEDRVWDPEKIVVIFDHQVPADSIEAAQNHMIMRDFVEEQGIRNFYDVREGVCHQVLPEKGHVVPGEVVVGTDSHTCTHGALGAFATGIGSTDMAMVFATGKLWFRVPETLRFDVRGKLREHVYAKDVILNIIGRVGADGATYMACEFAGETVAEMSVSDRMVLSNMAIEMGGKTGIVEPDEKTLNYVRRRSGKPWRVFKTDPDAPSLSVMEVDVSDLEPQVACPHNVDNVKPVTEVEGTEIDQVFLGSCTNGRLSDLRDAAAILKNRKVSDSVRMLVIPASREVYRRALDEGLIEIFVDAGALVCNPCCGPCLGGHVGLVGPGEVSLSTSNRNFRGRQGSPEAEVYLSSAAVAAASAVKGSITHPGSLK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
Probable 3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
Protein: ORN_HAEIE
Sequence: MPFDKQNLIWIDLEMTGLDPEKERIIEIATIVTDKNLNILAEGPVLAVHQSDELLNKMNDWCQKTHSENGLIERVKASKLTERAAELQTLDFLKKWVPKGASPICGNSIAQDKRFLVKYMPDLADYFHYRHLDVSTLKELAARWKPEILEGFKKENTHLALDDIRESIKELAYYREHFMKLD
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_NITHX
Sequence: MSRIGKRPVTVPSGVTATVEGQTVRMKGPKGQLEFVVHNDVEVKLENGAVKVAPRYETNRAQALYGTARAQVANLVAGVTKGFEKKLEIVGVGYRAALQGKTLQLALGYSHDVSYAIPEGITIAVPKPTEITIAGNDAQRVGQVAAEIRGYRPPEPYKGKGVKYADEFIFRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: DNAJ_LATSS
Sequence: MAEKRDYYDVLGVGRDASDDEIKKAYRKLSKKYHPDINKAPDAEAKFKEVTEAYEALSDPQKRAAYDQYGHAGMNGGFGGGAGAGQGFGGFGGGAEGFGGFDDIFSSFFGGGARQQPNGPRQGSDLQYRMDLKFEEAVFGKETKISYSREAECHTCHGSGAKPGTSAETCHKCHGAGQIQVERQTPLGRMMSRETCDVCGGTGKEIKSKCDTCHGTGREEERHTVKVKVPAGVEDGQQMRLQGQGEAGSNGGPYGDLFIVFRVAPSDEFERDGAQIFVEVPISFVQAALGDEIEVNTVHGPVKLKIPAGTQTNTVFRLRGKGAPKLHGTGNGDQNVTVNVVTPKTLNSKQRDALKAFAVASGDSVNPQDSNLFDKILNKKYKK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_SYNJA
Sequence: MANGNSFGVLFCVTTYGESHGGAVGVVVDGCPPRLPLSEADIQAELDRRRPGQSHITTPRQEADRCQILSGVFQGFTLGTPIHILVRNQDARPQDYSEMATTFRPSHADATYQAKYGIRNWQGGGRASARETIGRVAAGAIAKKILRLAAGVEILAYVQRVQDVEAQVDPSSVTAEQVEANIVRCPDPAAAAAMIEKIEAAAREGDSLGGVVECVARNVPRGLGCPVFDKLEADLAKAVMSLPASKGFEIGSGFAGTYLTGKQHNDEFYMTPSGWRTRSNRSGGIQGGISNGEDIVLRVAFKPTATIRQPQSTVTLDGQETVLAARGRHDPCVLPRAVPMVEAMVALVLCDHLLRHHAQCRSLALPEVPIPAVPLPHS
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: ATG5_YEAS7
Sequence: MNDIKQLLWNGELNVLVSIDPSFLMKGSPREIAVLRIRVPRETYLVNYMPFIWNKIKSFLSFDPLTDSEKYFWFEHNKTPIPWNYPVGVLFDCLAGKSATFTTSFENQVKDVLTFLRIHLVMGDSLPPTIIPIASSKTQAEKFWFHQWKQVCFILNGSSKAIMSLSVNEARKFWGSVITRNFQDFIEISNKISSSRPRHIPLIIQTSRTSGTFRISQPTISMTGVNPTLKDIEGDILDVKEGINGNDVMVICQGIEIPWHMLLYDLYSKLRSFDGFLYITLVPIKGGDKASSEL
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production.  Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.  ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
What are the official names of this protein?
Autophagy protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre-autophagosomal structure (PAS). Ultimately, the IM expands to become a mature autophagosome. Localizes also to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS). Correct localization to the PAS requires ATG21.
Protein: LLDD_ECO55
Sequence: MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALAPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQGLGKELPTALAPMAKGNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HV70D_HUMAN
Sequence: MDILCSTLLLLTVPSWVLSQVTLKESGPALVKPTQTLTLTCTFSGFSLSTSGMRVSWIRQPPGKALEWLARIDWDDDKFYSTSLKTRLTISKDTSKNQVVLTMTNMDPVDTATYYCARI
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 2-70D.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: BFAR_HUMAN
Sequence: MEEPQKSYVNTMDLERDEPLKSTGPQISVSEFSCHCCYDILVNPTTLNCGHSFCRHCLALWWASSKKTECPECREKWEGFPKVSILLRDAIEKLFPDAIRLRFEDIQQNNDIVQSLAAFQKYGNDQIPLAPNTGRANQQMGGGFFSGVLTALTGVAVVLLVYHWSSRESEHDLLVHKAVAKWTAEEVVLWLEQLGPWASLYRERFLSERVNGRLLLTLTEEEFSKTPYTIENSSHRRAILMELERVKALGVKPPQNLWEYKAVNPGRSLFLLYALKSSPRLSLLYLYLFDYTDTFLPFIHTICPLQEDSSGEDIVTKLLDLKEPTWKQWREFLVKYSFLPYQLIAEFAWDWLEVHYWTSRFLIINAMLLSVLELFSFWRIWSRSELKTVPQRMWSHFWKVSTQGLFVAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKELRRLETQVL
What is the function of this protein?
Apoptosis regulator.  Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.
What are the official names of this protein?
Bifunctional apoptosis regulator, RING finger protein 47.
Protein: PG049_VAR67
Sequence: MGTNTIRAFIILYLLAVCGCVEYDVDNNVQICTCANVSHINHTFWYYNNKVIALATEDRTSGYISSFIKRVNISLTCLNISSLRYEDSGSYKGVSHLKDGVIVTTTMNISVKANIIDLTGRVCYLTRNYCEVKIRCEIKSFALNGSITPLHMILGTLDRWKYLPFPTDDYRYVGELKRYISGNPYPIESLALEISATFNRFTIVKNNDDEFSCYLFSQNYSFHKMLNARHICESEWEALNNNNDNSSSMPVSHNNRANDLSSMMSQLQNDNDDNNDYSAPMNINNLIMIVLITMLSIIIIIIVVIAIIAMYKRSKYSHIDDN
What is the function of this protein?
Plays a role in the spread of virus to neighboring cells ex vivo.
What are the official names of this protein?
Protein OPG049, 36 kDa major membrane protein F5.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG049 family.
Protein: ISCR_SERP5
Sequence: MRLTSKGRYAVTAMLDVALHSQEGPVPLADISERQGISLSYLEQLFSRLRKNGLVASVRGPGGGYLLGKDASEIAVGAVITAVDESVDATRCQGKEGCQGGDRCLTHTLWRDLSERISGFLNNITLAELVNNQDVLVVADRQNNDTRRTANGRPQETINVNLRA
What is the function of this protein?
Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.
What are the official names of this protein?
HTH-type transcriptional regulator IscR.
Protein: SYK_LEUCK
Sequence: MAEEKALNDQMLARRQKLATIVDDLHLDPFGKRFERTAKAQELHDLYDNSTLETLESEQHEVVIAGRMIAKRGAGKVIFADFRDVSGKIQVYAKRDDLGENYPIIKRADLGDFLGIKGIIMKTEAGELTVLATELTHLTKALRPMPDKFHGIADVETRYRKRYLDLIANEESFKKFQLRSKIISAIRAYMDSQDFMEVETPILQTEAGGAAARPFITHHNALNIDMYMRIATELYLKRLVVGGFERVYEIGRIFRNEGMDPKHNPEFTTMETYAAYMDFTDVMDETEGIFKAAASVVSDDLKVTYQGTEIDLGSNFARKHMVDLIKEQTGIDFWQDMSVEAAQKLADDKHVKYEKYWGVGHIINAFFEEFVEDTLVQPTFVYGHPVEVSPLAKRNAEDSRFTDRFELFIMGSEYGNAFTELNDPIDQRARFEAQVAERENGNDEAENIDEDFIEALEYGMPPTGGLGIGIDRLVMLLTDSDTIRDVLLFPTMR
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.