PharMolix/UniProtQA huggingface dataset:
Protein: KPRS_PARMW
Sequence: MTSFLTAARAEQEKLTPDTRRLRLFSGTSNPGLAREIAAYLGVPDGPRVCKRFADGELYVQIQESIRGCDVFLIQPTCAPVNDHLMELLIMVDACRRASARQITAVVPYYGYARADRKTAGRESITAKLTANLLVKSGVDRVLAMDLHSAQIQGYFDIPCDHIYGSPVLVDYLSTQNLDDIVVVSPDVGGVARARAFAKQMNDAPLAIIDKRRTGHNLAESLTVIGDVSGRTAILIDDMIDTGGTICAGARLLRQQGAKRVIACATHAVFSPPASERLSADGLFEQVVVTNSIPIQQERTFPQLQVLSVANMLGEAIWRIHEESSVSSMFR
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2077_SYMTH
Sequence: MRLAKEVEAALDLLIIFLAQATYVSVNTVRWIILVKGRRLLASAISFFEVILWVYALGLVVSQLSDPVKVATYALGYAVGALVGSKIEERLALGYVLFQVITTRIGELAPALREHGLGVTDWRAEGRMGQREVLMVVARRKNGPQVVRLLEELDPQAFVVQLDASWYRGGFIQKMLQ
What are the official names of this protein?
UPF0316 protein STH2077.
What is the protein family that this protein belongs to?
Belongs to the UPF0316 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPE_ECOHS
Sequence: MRTQWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTISIELRDDGDIRLLTPVEGVEHEDNLIVRAARLLMKTAADSGRLPTGSGADISIDKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSMDELAEMGLTLGADVPVFVRGHAAFAEGVGEILTPVDPPEKWYLVAHPGVSIPTPVIFKDPELPRNTPKRSIETLLKCEFSNDCEVIARKRFREVDAVLSWLLEYAPSRLTGTGACVFAEFDTESEARQVLEQAPEWLNGFVAKGVNLSPLHRAML
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: VATA2_ACEAT
Sequence: MSKAKEGDYGSIKKVSGPVVVADNMGGSAMYELVRVGTGELIGEIIRLEGDTATIQVYEETSGLTVGDGVLRTKQPLSVDLGPGILGNIFDGIQRPLKAIADVSGDVFIPRGVNVPSLDQTKQWEFHPSSYRVGDRVTGGDIIGTVPENTLLDHKVMLIPQAKGTITYIAPAGNYNINERIIEVEFQGTKYEYCMKQSWPVRSPRPVVEKLLADTPLLTGQRVLDSLFPGVRGGTCAIPGAFGCGKTVISQALSKYSNSDGIVYVGCGERGNEMAEVLMDFPQLTMTMPDGREESIMKRTTLVANTSNMPVAAREASIYTGITLSEYFRDMGYNFAMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERSGRVACIGSPEREGSVTIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNWLISYSKYLNALEPFYEKFDNDFVDIRQVAREVLQKEDELNEIVQLVGKDALAESDKIILETADFLKEDYLAQNSFTKYDKYCPFYKSVGMMRNIVTFHRLATQAIERTATGNSDGQKLLSNIIKAKLGDLLYKVSSQKFEDPSDGESVVTGRLNELNDELKEKFRALEDEYS
What is the function of this protein?
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase.  V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
What are the official names of this protein?
V-type proton ATPase catalytic subunit A isoform 2, V-ATPase subunit A 2, V-ATPase 69 kDa subunit 2, Vacuolar proton pump subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: HEY1_BOVIN
Sequence: MKRAHPEYSSSESELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGSAFGHHPHVAHPLLLSQSTHGNTGTSASPTESHHQGRLATAHPEASALRAPPSGGLGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTEIGAF
What is the function of this protein?
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'.  Downstream effector of Notch signaling required for cardiovascular development.  Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development.  May be required in conjunction with HEY2 to specify arterial cell fate or identity.  Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification.  Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3.
What are the official names of this protein?
Hairy/enhancer-of-split related with YRPW motif protein 1.
What is the protein family that this protein belongs to?
Belongs to the HEY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DADA_NEIG1
Sequence: MKVLVLGAGVAGVSSVWYLAEAGHEVTVIDRTEGVAMETSFANAGQLSYGYTTPWAAPGIPTKALKRLFKSHPPLLFRPDGGLYQIEWLWRMLQNCTATRYQINKERMVRISEYSREMFRRFEAQTDMNFEGRKKGTLQIFRQTEEVEAAKQDIAVLERYGVPYRRLKPEECAEFEPALARVTAKIVGGLHLPADATGDCRLFTENLYKLCQEKGVRFYFNQTISRIDHNGLRIKAVETETGRFETDAVVCALGCFSRTVLAQLDLNLPIYPVKGYSLTLPVTNSDGAPVSTVLDESYKVAITRFDNRIRVGGMAELSGYETKLPEKRRETLALVVNDLFPEGGDLSQALSWSGLRPMTPDSTPLIGRTRFENLFLNTGHGTLGWTMSPGSAKLTADIVSGKDTEIRSDDLSLSRYQKL
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: ECFA1_STAAS
Sequence: MEDKNSVIVFKNVSFQYQSDASFTLKDVSFSIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQTITDDNFEKLRKDIGIVFQNPDNQFVGSIVKYDVAFGLENHAVPHDEMHRRVGEALKQVDMLERADYEPNALSGGQKQRVAIASVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAMEADHVIVMNKGTVYKEGTAIEIFDHAEELTTIGLDLPFPIKINQMLGYQTSFLTYEGLVDQL
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: 1433Z_XENTR
Sequence: MDKNELVQKAKLAEQAERYDDMAACMKRVTEEGGELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQEMSREYREKIEAELREICNDVLNLLDKFLIANASQPESKVFYLKMKGDYYRYLAEVASGDAKADIVAQSQKAYQDAFDISKTEMQPTHPIRLGLALNFSVFYYEILNCPEKACSLAKAAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEQGEGGEN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.
What are the official names of this protein?
14-3-3 protein zeta.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_NITEC
Sequence: MNTFPAPAKLNLFLHVIGRRDDGYHLLQTVFRFIGYSDQLGFDVTNDGVIRHLNLVPGLTDTDDLCVRAAKLLQKRSGKEMLGVGIHLSKNIPLGGGLGGGSSDAATTLIVLNRLWGINWGRERLMALGLELGADVPIFIYGRNAFAEGVGEKLEVINLPPAWYVVLTPPAPISTAAVFASRELTRNTIPIKMAAFSMAQGHNDLELVAMRLQPVIAEWLDWLKGRHGSTKVAMSGSGSCVFAEFPSESAAREVLRQLPDSMSGFIAPGLARHPLSDF
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: FABZ_CHLSY
Sequence: MLSIQEIMALIPHRYPFLLVDRIMELEPGVRAVGEKLVSANEPYFQGHFPGNPIMPGVLILEALAQTGAVAALSAPENAGKLVLFAGIDGARFKRVVRPGDTLRLEVQLEKMRRGVGKGQARATVADQLACEAELLFALTDPSR
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TILS_GEMAT
Sequence: MPADGIPEGIPAEDLLRASIEVALAAVREPLVLAVSGGSDSMALLFAMERWAPDRIAAVATFDHGTGSYATDAASLVAAHGRRLGLTVIRERARRPGVNEAAWRDARWSFLQRVARGFHARVATAHTRDDQAETVVMRLLRGSGARGLAALAAPSPVVRPWLGVSREELTRWLASEGLPFLEDPMNASRYFLRARVRHELLPACEAASPGFRDAMLLIGERAARWRREVEQYLDQAGLVVEHAGRSASLPVEVLEQTTPEGQAVLWAALSARAGVTLDAHGTRAAVRFTSSRRRGAYITVAGGAAIMRTRRAAEQVASDVGADRGIRAPAGVGERFVVRSRAAASEAVEWSGESTTLPRRLGQWRFRRLAAAPAAFDAWHMGLPAGTSVVVRPWREGDRIRSAGAAAGRRVTRYFTESRIPVPDRSQWPVVLVDDEVAWVPGVCRGLAAPSRSGRSELIWYRCEREFD
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_LEGPC
Sequence: MTTKKQPDSTIALNRKAGFDYFIEDQYEAGLVLEGWEVKSLRAGKINLSDSHVIIKYGEAFLLGAQIQPLPTASTHFIPDPIRTRKLLMNKKELNHLIGSVERQGYTIVPLSLYWKKNKIKIKIALAKGKKEHDKRDTIKDREWQRDRSRIMKKNT
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: HNDC_SOLFR
Sequence: MAATTTEKKQLRIATRNCGFIDPESIDDYIALRGYEGLAKVLTMTPAEVVDLVKRSGLRGRGGAGFPTGIKWGIALGNKADQKYMVCNADEGDPEFMDRAVLEGDPHSVVEAMAIGGYAIGATRGTVYIRAEYPLAIKRLKKAIDDAREYGLLGENIFGSGFDFDIELKYGAGAFVCGEETALIRSMEGKRGEPVTKPPFPAQSGYWEKPTIVNNVETFANIPAIIINGADWFSGIGTATSKGTKVFALAGKIQNVGLIEVPMGISLREVIFDIGGGCPDGKAFKAVQTGGPSGGALANKDLDVAIDYESLAACKSIMGSGGMVVMDEDDCMVSVAKFFLDFTMDETCGKCTPCRIGSKRLYEILDRITKGKGTRADLDRLKSLSEIIKDTALCGLGQTMPNPILSTMDTFANEYEAHVDDKKCPAHVCTALLTYTIDPAKCTGCGLCTRVCPVECISGTKKQPHTIDTTRCIKCGACYDKCKFDSIIKQ
What is the function of this protein?
Catalyzes the reduction of NADP in the presence of molecular H2 to yield NADPH.
What are the official names of this protein?
NADP-reducing hydrogenase subunit HndC, Hydrogen dehydrogenase (NADP(+)).
What is the protein family that this protein belongs to?
Belongs to the complex I 51 kDa subunit family.
Protein: Y722_HAEIN
Sequence: MAEYLVPKSAVVFEEEIKKSRFITYLQHTEGLEDARAFWAKIKQEHPNARHHCWAAVAGKPTDSLQLGFSDDGEPAGTAGKPMLSALQGSQLGEISAVVVRYYGGILLGTGGLVRAYGNGVQQALKLIESEIKVERTLFKLDCDYGQLRLVQQLCEKYQVEILSQGFQANIHLILGISEKTIEAFSSELTEKSSGRLVIQLLEIGE
What are the official names of this protein?
IMPACT family member HI_0722.
What is the protein family that this protein belongs to?
Belongs to the IMPACT family.
Protein: NDHI_ZEXSE
Sequence: MFPMVTEFMNYGQQTIRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: Y0306_DICDI
Sequence: MIVNQALIELTKQVAVAVEEIKFSPNSTSNNSTPTNNKLKSSSSSISNCDSPSSKSKSNSSTSTPTSQPQTPSQLPQQAQQQAQQQHYSANSMNPYYAQQVLLQLQKPSTFVKHVHVVVKNTPFGITLRSKEPLQFNFQNYVIKATLLYDSDPPKMVDFIHNEPLQYVATVSEDGSEVCVDVKVGILSSQHQGSMFLVVLHISHCSAPTPSNSEPISTILTNIGNNSIHSLNVTNICVVSHPIRIVSKLDHVKKEGIPILKKRTFHEILTDKLKKLQKSQDSQSKWIKNLYQQHGAQYDMEPYNSTLHSQKTDSLCSSSTSTPSFNSTSSSSKNQSQSIKNEEEEDGGEDEEEEGGEDNDNESESSNTNSTQLIGKKSINKLPISTTTSSSNFNNLMVNNNINNNNNNNNNNHLIQNTTFSSTSHFQNSFNRVVEVYNLIPEYERVEVIRKMVQQLKSYDLEQLVSTFIDELKCGYESTIIS
What are the official names of this protein?
Uncharacterized protein DDB_G0270306.
Protein: HIS6_CLAM3
Sequence: MAASAASGPSAQLAVRVIPCLDVAAGRVVKGVNFLDLQDAGDPVELARLYYEQGADELTFLDVTATVEDRSTMYDVVSATAEQVFIPLTVGGGVRSADDVARLLASGADKIGVNSAAIARPDLVGEIADRFGAQVCVLSLDITRGDTESGFVVTTHGGRTRTTIDAVAWAREAVERGAGELLVNSIDADGTRDGFDLELVAAMRAASRVPVIASGGAGELDHFAPAIEAGADAVLAASVFHSRRFTIGDVKGALADAGQVVRR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_SALNS
Sequence: MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKDRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVMGLISTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVIHDVAIQKLPVMFAIDRAGIVGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGNAQGVALTPLEKLPIGKGLVKRHGEKLAILNFGTLMPEAAKVAEALNATLVDMRFVKPLDDTLILEMAAQHDALVTLEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEARAELGLDAAGIEAKIKAWLA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: MAP1_MYCBO
Sequence: MPSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: HDA_SALDC
Sequence: MSSWVEVSLNTPAQLSLPLYLPDDETFASFWPGDNASLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECVAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDHASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: PUCB_BACSU
Sequence: MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSSRLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESMGADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLKGDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS
What is the function of this protein?
Required for xanthine dehydrogenase activity.  Could be involved in formation of the molybdenum cofactor required by xanthine dehydrogenase.
What are the official names of this protein?
Purine catabolism protein PucB.
Protein: MUTS2_STACT
Sequence: MRQKTLDVLDFDKIKAQVENEAVSDLGRVKAAAMTPASDYETVVFQMNETDELSQIYNKHRLPSLSGLTEVKPLIHRAKIGSILNVRELNQIKRLIQVQNQYKTFYSQLLEEEEAINYPILDERMAQLPILTDLYQEIHQKCDAYDLFDDASHELQSIRSRIHSTSQRIKQNLDRIVKSQSNQKKLSDAIITVRNDRHVIPVKAEYRQDFNGIVHDQSSSGQTLYIEPSAVVEMNNKISRLRNDEKVEVERILSVLSGEVAAEADACLIAESVMGQIDFLTAKARYGQSIKGTKPEFTEERNVYLPKAFHPLLDRATVVANTIEFAEDIQTVIITGPNTGGKTVTLKTLGLIIVMAQSGLLIPALDGSKLSVFDNVYCDIGDEQSIEQSLSTFSSHMKNIVEILKHADHNSLILFDELGAGTDPSEGAALAMSILDHVQKLGSLVMATTHYPELKAYSYNREGVMNASVEFDVNILSPTYKLLMGVPGRSNAFEISSKLGLSGNIIREAKSLIGQDEQEINNMIASLETNAKKVEDQRIELDRLLREAKQVHGDLNKKYEQYQNYEKQLMDDAKVKANQRVKAATKEADDIIKDLRHMRDEKNAEVKEHELIEKRKHLDEQYEGTDIKQNVKKQKWDEIQAGDEVKVLTYGQKGEVLEILDDDEAVVQMGIIKMKLPIADLEKKKKAQEKPAKTVSRTNRSAVKMELDLRGYRYEEAITALDQYLDQAMLSNYENVYIIHGKGTGALQKAVQQHLKKHKNVASFRTGMPSEGGFGVTVAELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: PA2B_LATSE
Sequence: MYPAHLLVLLAVCVSLLGASAIPPLPLNLVQFTYLIQCANKGSRASYHYADYGCYCGAGGSGTPVDELDRCCKVHDDCYGEAEKMGCYPKLTMYNYYCGTEGPYCNTKTDCQRYVCACDLQAAKCFARSPYNNKNYNIDTSKRCK
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 cL038, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: G6PI_BACP2
Sequence: MTHIQFDYSKALPFFQEHELTYLKDFVKVAHHNIHEQTGTGSDYLGWVDLPKQYDREEFARIKKSADKIKSDSDVLLVVGIGGSYLGARAAIEFLNHSFYNTLPKGKRKTPQIIFIGNNISSSYLTDVMDLLEDADFSINVISKSGTTTEPAIAFRIFKKLLIEKYGAEEAKKRIYATTDKARGALKTLATEEGYESFIIPDDVGGRYSVLTAVGLLPIAVSGADIDQMMEGAAKASEDFASSELSENAAYQYAVVRNVLYNKGRTIEMLINYEPGLQYFAEWWKQLFGESEGKDEKGIYPSSANFSTDLHSLGQYVQEGRRDLFETIVNVDKPRHELVIEAEEQDLDGLNYLAGKTVDFVNKKAFEGTMLAHTDGKVPNLIVTIPEMDAYTFGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELESRLKQS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_AERPE
Sequence: MACSRARARAYSSAANLGPGFDALAVALDAYYDEVEVRVCSGGNSVYVDEVEGKFSSGVLQGPNTAAEAVRGLLNMEGVEAEVGIRVYKGVPPGRGLGSSGASAAAAVAAVSHALALEVPVDRLVFYAGLGERAAAGQPHFDNAAASILGGLAVVASDAAGKLRVFRVPFKAWFAVVTPMNPVPQGKTGVMRKVLPENVSFRDAVRNFSRAAGIVAAAVNGDLKSMGALMMSDEIVEPRRRSYVPCYTQVRKAALQAGALGFSLSGAGPSMIALAPSSEAAREIAAAMEESCICCDNPMTVAAEPAPGASVVG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_ALKMQ
Sequence: MENSKKTPLFTVYEKHKGKLIDFGGWAMPVQFEGIIPEHEAVRSNAGLFDVSHMGEVEIKGKDALNFVQYLITNDASQMEKNQIIYSFMCYENGGVVDDLLVYKFEEDYFYLVINAGNIEKDYEWMLKQSTAYDVEVNNISNDVSELALQGPKAEKILQKLTETDLSQLQFFYLQRDVTIDGVNCLISRTGYTGEDGFEIYVNPSDAVQLWEKLLEVGQEDGLKPIGLGARDTLRFEAALPLYGHEINRDITPLEAGFGFAVKLKKEVDFLGKKALIEQKEAGLTRKLVGFEMKDRGIPRSDYEVYHQGEKIGFVTTGYFSPTLKRNIGLALIDAKYAELGNEVDILIRKKQVKAELISKTFYKKNYKK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: PORED_RAT
Sequence: MAGWAGAELSVLNPLRALWLLLAAAFLLALLLQLAPARLLPSCALFQDLIRYGKTKQSGSRRPAVCRAFDVPKRYFSHFYVVSVLWNGSLLWFLSQSLFLGAPFPSWLWALLRTLGVTQFQALGMESKASRIQGKKLALSTFLVLVFLWVHSLRRLFECFYVSVFSNTAIHVVQYCFGLVYYVLVGLTVLSQVPMNDKNVYALGKNLLLQARWFHILGMMMFFWSSAHQYKCHVILSNLRRNKKGVVIHCQHRIPFGDWFEYVSSANYLAELMIYISMAVTFGLHNVTWWLVVTYVFFSQALSAFFNHRFYKSTFVSYPKHRKAFLPFLF
What is the function of this protein?
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol (PubMed:8486680).  Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:8486680).  Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (PubMed:8486680).  Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity).
What are the official names of this protein?
Polyprenol reductase, 3-oxo-5-alpha-steroid 4-dehydrogenase 3, Steroid 5-alpha-reductase 3, S5AR 3, SR type 3.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
Protein: YO035_YEAST
Sequence: MRVYHHIYVYTYILSAVIYSQDLFPSWVVQLSTVKSDIIRPYLIHGNSFLFQILQVLITAPSTRCKFSFQNSIPFIFLALLLSQDFHVFLGIELHAFFVS
What are the official names of this protein?
Putative uncharacterized protein YOL035C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.