PharMolix/UniProtQA huggingface dataset:
Protein: BAG7_YEAST
Sequence: MFNMNLLSTPSSEEGSPQNRSSSMSSVEGKKDRDTFTNLQNEFDGKVFGVSLEESLKVAQEEVIIQKSTNEIGSIPVVIAKSGKYLKENALDTTGIFRIAGSNKRVRELQAVFSKPPDYGRKFEGWCDFNVHDIATLLKRYLNSLSEPLVPLALYDIFRNPILENPKINEHKEQIIKDYEDIYMLLPQQNRHLILYLAALLNLFARNEKKNLMSASNLAAIVQPSLLSHPKDEMCPKEYEASRTVIEFLILHASDIIPNTEKANKDTMPHAGTVAKFNNITVPEMAIDSDEEDFVHPSIDDHMLPRSRALSDSNNFTIHHHHHHHHALFPSPIDFDNNGLSVPRSFKGRTLSAESLSPRLSKLLGNVGNSSNTGIKDPTERVPRGEHKTKHKQRQSWLRRLTSPSRTQP
What is the function of this protein?
Acts in signal transduction.  Activates RHO1.
What are the official names of this protein?
Rho-GTPase-activating protein BAG7.
Protein: ROK1_CANAL
Sequence: MDIFRILSRGASLNKKKGITTDYALPSEKQTQKQKHKQESLLNEVERETDFFHTRKHNSNSTTTSGKGDKLTNGANSNKEEQMETNETKAKEEEIPPPELTTEEDAQTFRNLHKSKVTGDDIPIPIGSFQDMIGRFHINKKVLSNLIDNEFVEPTPIQCESIPITLNNRDLIACAPTGSGKTLAFLIPLVQQILSKNVSKNHGIRGLIISPTNELAVQIFQELEIITRGCKQINVAILSKQLASKLNNNIIKSSKYDIIVSTPLRLIDVVKQGNMDLSKIEQLIIDEADKLFDHGFAEQTDEILTHCTNPKIRKSIFSATIPSSVEEMAHSIMKDPLRIIIGHKEAASNTIDQKLVFTGNEQGKLLAIRQMIQQGEFKPPIIIFLQSITRAKALFHELLYDRLNVDVIHAERTPKQREEVIKRFKNGDIWVLITTDVLARGVDFKGVNLVINYDVPQSAQAYVHRIGRTGRGGKAGKAVTFFTKEDDKAIKPILNVMKQSGCNDGYSQWMEDMGKLSKKEKKQIKTHEIQRKKISTVPKVIKQKRKQRQDMIAASKRRKQESKQESKQESHSNDEREE
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase CHR1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SYYC_PONAB
Sequence: MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLTFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDERWGGNKTYTAYMDLEKDFAAEVVHPGDLKNSVDVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGERVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
What is the function of this protein?
Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).  Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity.  Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1.
What are the official names of this protein?
Tyrosine--tRNA ligase, cytoplasmic, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCPI_SOLLC
Sequence: MAQKFTILFTILLVVIAAQDVMAQDATLTKLFQQYDPVCHKPCSTQDDCSGGTFCQACWRFAGTCGPYVGRAMAIGV
What is the function of this protein?
May play a defensive role against insect attacks.
What are the official names of this protein?
Metallocarboxypeptidase inhibitor, Carboxypeptidase inhibitor, MCPI.
What is the protein family that this protein belongs to?
To potato MCPI.
Protein: H2A_PENVA
Sequence: MSGRGKGGKVKGKSKSRSSRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIVPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTEKK
What is the function of this protein?
Has antimicrobial activity against the Gram-positive bacterium M. luteus.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL15_CHLPB
Sequence: MDLSSLRPAKGAVKNKKRIGRGPGSGNGTTAGKGNKGQQSRSGYTRPVSEGGQMPIYRRLPKFGFTKPNRKNVIPVNLSQIALWMENGKATSEITVENLKSLCSARRADYFKILGNGELKSPVTITAHFVSKSAQEKILQAGGTITLAERTLLEAERIKDTPVEEGLMKPKARLRKKKKIKS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ALF_BUCBP
Sequence: MCNILNKIKPGVITGNEALKLFKIAKKNHFAIPAINCINTDSINIVLETAKKAKSPVIIQFSYGGSNFISGPGLTTNILHKKAIIGALSGANHVHIMAKHYNVPVILHTDHCNKNMLPWIDELINVGTKHFKTYNKPLFTSHMIDLSNEKLDYNINICSKYLEKMRKINMLLEIELGCTGGEEDGINNTKINKSLLYTQPNEVNYAYERLSSVGPEFIIAASFGNVHGVYKSGNVRLTPDILKKSQNYVSKKHNLSCNPLCFVFHGGSGSSEKDIKKSIKYGVIKMNIDTDIQWATWQGILNFYNKNNKYLHNQIGNLDNENKPNKKYYDPRTWIRSSQISVSNHLTKIFRILNSCNTL
What is the function of this protein?
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
What are the official names of this protein?
Fructose-bisphosphate aldolase class 2, FBP aldolase, FBPA, Fructose-1,6-bisphosphate aldolase, Fructose-bisphosphate aldolase class II.
What is the protein family that this protein belongs to?
Belongs to the class II fructose-bisphosphate aldolase family.
Protein: PACN1_DANRE
Sequence: MSGAYDESAMSDETTDSFWEVGNYKRTVKRIEDGHRLCNDMMSCIQERAKIEKAYSQQLTDWSKRWRQLVERGPQYGTLERAWLAVMTEAEKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQMMGGFKETKEADEGFRKAQKPWAKKLKELETAKKTYHMACKEEKIASAREANSKGEASVTTDQQKKLQEKVDKCKNDVQKAKEKYEKSLDELNKCTPQYMENMEVVFDQCQQFEEKRLNFLREVLLDTKRHLNLTESQSYATVYRELERTIVSASAQEDLKWFSSVHGPGMHMNWPQFEEFNPDLSHAISKKEKVKRNHDGVTLTQVTHGAEHGTPQTGDRGSVSSYEKNQQYSAEWSDDEQPPTAAQSASETNGGNPFEEDSKGVRVRALYDYEGQEQDELTFKAGDELTKLEDEDEQGWCKGRLDSGQLGLYPANYVEPV
What is the function of this protein?
Binds to membranes via its F-BAR domain and mediates membrane tubulation.  Plays a role in cellular transport processes by recruiting dynamins to membranes.  Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex.  Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length.  Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission.  Required for normal excitatory and inhibitory synaptic transmission (By similarity).  Required for normal embryonic development, including normal development of laterality, normal body size and shape, as well as normal brain and heart development.  Required for normal development of stereocilia and kinocilia in sensory hair cells of neuromasts in the posterior lateral line organ, and thus also for balance keeping and normal swimming behavior.
What are the official names of this protein?
Protein kinase C and casein kinase substrate in neurons protein 1, Syndapin-1.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Synapse, synaptosome. Synapse. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Note=Detected in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Detected at vesicular structures in neuron cell bodies and neurites (By similarity). Detected at the apical surface of cells at the basis of forming cilia, but not in the cilia themselves.
Protein: DUT_ANADF
Sequence: MPVTVKVRRVGQRGPPLELPRYETDGAAGLDLRADEPVTLAPGERRLVPTGLALEIPPGHEGQVRPRSGLAVRHGVGMVNAPGTIDSDYRGEVGVVLVNHGQEPVTFARGDRIAQLVIGPVVRAELALVEDLASSGRGGGGFGSTGR
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RDRP_ROTTU
Sequence: MGKYNLILSEYLSFIYNSQSAVQIPIYYSSNSDLEKRCIEFHSKCLENSKKGLSLKNIFVEYKDVVENATLLSILSYSYDKYNAVERKLVYYAKGKPLEADLSANKLDYENNKLTSDLFPTAEEYTDSLMDPAILTSLSSNLNAVMFWLEKHANDTAEKAKIYKRRLDLFTIVASTVNKYGVPRHNAKYRYEYEVMKDKPYYLVTWANSSIEMLMSVFSHEDYLIAKELIVLSYSNRSTLAKLVSSPMSILVALVDINGTFITNEELELEFSNKYVKAIVPDQTFEELKEMLDNMKKAGLVDIPKMIQDWLVDCSIEKFPLMAKIYSWSFHVGFRKQKMLDAALDQLKTEYTEDVDDEMYREYTMLIRDEVVKMLEEAVKHDDHLLQDSELAGLLSMSSASNGESRQLKFGRKTIFSTKKNMHVMDDMANGRYTPGVIPPVNVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKMLLYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNAMVLYTDVSQWDSSQHNTQPFRKGIIMGLDILANMTNDAKVIQTLHLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRIANKYSFVTKIIRVDGDDNYAVLQFNTEVTKQMVQDVSNDVRDTYARMNAKVKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAVLYSNYIVNRLRGFETDREFILTKIMQMTSVAITGSLRLFPSERVLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADEIAASQTFKNYVSKLSDQLLVSKNTIVSRGIALTEKAKLNSYAPISLEKRRAQISALLTMLQKPVTFKSNKITINDILHDIKPYFVTSEANLPMQYQKFMPTLPNNVQYIIQCIGSRTYQIEDDGSKSAISKLISKYSVYRPSIEELYKVISLHEQEIQLYLVSLGIPKIDADTYVGSKIYSQDKYRILESYVYNLLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEIINYAIKNGSWISLFCNYPKSEMIKLWKKMWNITSLRSPYTNANFFQD
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with VP3 capping enzyme, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.  Following infection, the outermost layer of the virus is lost, leaving a double-layered particle (DLP) made up of the core and VP6 shell.  VP1 then catalyzes the transcription of fully conservative plus-strand genomic RNAs that are extruded through the DLP's channels into the cytoplasm where they function as mRNAs for translation of viral proteins.  One copy of each of the viral (+)RNAs is also recruited during core assembly, together with newly synthesized polymerase complexes and VP2.  The polymerase of these novo-formed particles catalyzes the synthesis of complementary minus-strands leading to dsRNA formation.  To do so, the polymerase specifically recognizes and binds 4 bases 5'-UGUG-3' in the conserved 3'-sequence of plus-strand RNA templates.  VP2 presumably activates the autoinhibited VP1-RNA complex to coordinate packaging and genome replication.  Once dsRNA synthesis is complete, the polymerase switches to the transcriptional mode, thus providing secondary transcription (By similarity).
What are the official names of this protein?
RNA-directed RNA polymerase, Protein VP1.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging (By similarity).
Protein: NAGZ_NEIG2
Sequence: MTVPHIPRGPVMADIAAFRLTEEEKQRLLDPAIGGIILFRRNFQNIEQLKTLTAEIKALRTPELIIAVDHEGGRVQRFIEGFTRLPAMSTLGEIWDSEGAETAETHAEHIGWVLATELSACGIDLSFTPVLDLDWGNCAVIGNRSFHRNPEAVARLALALQKGLAKGGMKSCGKHFPGHGFVEGDSHLVLPEDGRSLDELEAADLAPFRIMSREGMAAVMPAHVVYPQVDTKPAGFSEIWLKQILRRDIGFKGVIFSDDLTMEGACGAGGIKERARISFEAGCDIILVCNRPDLVDELRDGFTIPDNQDLAGRWQYMENSLGHEAVQAVIQTTGFQAAQAFVAGLASPQDTAGGVKVGEAF
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROT3_ARATH
Sequence: MNSKNRINNVGEGVDIEIPDTAHQISSDSWFQAAFVLTTSINSAYVLGYSGTVMVPLGWIGGVVGLILATAISLYANTLVAKLHEFGGKRHIRYRDLAGFIYGRKAYCLTWVLQYVNLFMINCGFIILAGSALKAVYVLFRDDHAMKLPHFIAIAGLICAVFAIGIPHLSALGIWLAVSTILSLIYIVVAIVLSVKDGVKAPSRDYEIQGSPLSKLFTITGAAATLVFVFNTGMLPEIQATVKQPVVKNMMKALYFQFTVGVLPMFAVVFIGYWAYGSSTSPYLLNNVNGPLWVKALANISAILQSVISLHIFASPTYEYMDTKFGIKGNPLALKNLLFRIMARGGYIAVSTLLSALLPFLGDFMSLTGAVSTFPLTFILANHMYYKAKNNKLNTLQKLCHWLNVVFFSLMSVAAAIAALRLIALDSKNFHVFADL
What is the function of this protein?
Proline transporter that mediates proline and glycine betaine transport.  When expressed in a heterologous system (yeast), imports L-proline, glycine betaine and GABA across the plasma membrane.
What are the official names of this protein?
Proline transporter 3, AtPROT3.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.3) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Plasma membrane.
Protein: RUVA_PSEPW
Sequence: MIGRLRGTLAEKQPPHLIIDVNGVGYELEVPMTTLYRLPKVGETVTVHTHLVVREDAHLLYGFHEKRERELFRELIRLNGVGPKLALALMSGLEADELVRCVQAQDTSALVRVPGVGKKTAERLLVELKDRFKAWETSPAMFTLVSDGPVPVSGASTAEADAVSALVSLGYKPQEASKAVSAIKDKAGLSSEELIRRSLKGMITK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PUR7_PARMW
Sequence: MSPDHGELLYEGKAKRIYATDHPDQVLVEYKNDATAFNAQKKAQLADKGRLNCQISARLFELLEGQGVPSHYLGLAGDTWMLVQRVEVIPLEVVLRNIATGSLCRQTPIAEGTPINPALLDLYYKDDDLGDPLLTEARVRLLGLVDDARQSAIEQLARRINGVLQPFFDGLELQLVDFKLELGLNKAGELLLADEISPDTCRFWDQRSSDTNDRILDKDRFRKDLGGVMEAYGEVLKRVHTACPNPRNCL
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: Y0785_DICDI
Sequence: MISNKRKEIENINRHHEKDNDDDDSDGIDNGLLTYKKFKKDFDSGSTNYRELQIIAKSLGLASNGKKQLVYNRIEGYFLSKKVKNNLTNNETNQQEEKKEEEQQQPQPQEKQYILTFKDVEPVEIYFWKVFRNIVIFKHIFSNFKNKQYGYYDLIGCNGVFLNGKSNSMEIIIDNIKSNNNNQIIRNKYNITNIINKFKKNDEKTRSFYNLLFSRYSSTSTSLPIQLSSTIQFDEDIDKWIQRMIENVNFTALDQFIKFFKIDSEVIKKAIKIHVKPSVFGNTTYDKLKIYNYLKSINSIPTSHKLLPFISTDLSAFLSFDNKFKKLIKSYKRLIESTNLQERMEQQEQKEKIKIHPNNKKYYEKLNQKILELNEIQTSQFTNDQLNSTIKNLLNHTTPTSTSTSTSTSTSTLTLTLTPTTNLTITTSTASNNINLKDIIKKFYKSICLFFYCSVYSANERLFRKPLLYYLNFKKESVDKMYERVVNKWNGRSFDHQLFFQSILKDINIEKNEKFELILNVLDNKYVKTFEEYDHYIFFKAVFSSNDIELIDYFLKKIKQLQLNQTQKITKYPSIGKLIGDYCHLIDKKEILDFYFQNYRDECLFFKDQNEIWKQIQLELIEHYEYLMDSIGKRCKLDFYRWFDQNFLDRLNIAILKPSVYSIGFDGYFDIVSEGLVDSNIKDNKENSIINFLSNAQLKHPLSLEIFESSFNPYTSKMLTFIKFLFNNISKESIETKLKVINLKTDNKSFEEINSKIELTTTLTATTTTTTTTTTTKTTTTTTTTANLLSPKKSKDVGCLTIGKTESFNFTISIRMLLVCLYNLDRVDDIIYLFDKLPEVLFNPDYFSIFTNEYCIYGISSSYYLELFINYFIANINDNTINYLYNCLCIASKKGYTQIFKNIISSDQNSKYLLKIQTKSNQSSLFNSKLLNDIVVKSINSLNFELSNLLIDFIDFSAKDKNSLKMKILKLK
What are the official names of this protein?
UPF0746 protein DDB_G0280785.
What is the protein family that this protein belongs to?
Belongs to the UPF0746 family.
Protein: C82X1_PAPSO
Sequence: MELFIKLPFIQPIPFSIILVTTVSIVLLYSVFFWVTDKKKKRKKAPNAAGAWPLIGHLRLLMNDKEPLYRALGSMADKYGPAFNIRLGNQEVLVVSNWEMVKQCFGNQNDKLFSNRQTTLAAKYMLNQTTSSGFAPYGPYWRELRKIMVQQLLSKQSLESWKHLKIKEMDASFSKLNELCNNNGTGTATLIRMDEWFAELTFNVIARNVFGYQSGGRSTALTNGDTESKGERYKKTLEEALHLMSIFAVSDIFPSLEWVDRLRGLIRNMKRFGDELNSIAGCLIEEHRQKRLQSVSKSDKGVGDEQDFVDVLLSVAEKSQLPGDDPDLVIKSMILEIVSGGSETTSSTLTWALCLLLNHPHVLKKAKEELDTHVGKDRHVEESDTPKLVYINAIIKESMRLYPNGAMLDRLALEECEVGGFHVPAGGRLFVNVWKIQRDPSVWENPLEFKPERWFLSNGEKMDVDYKGHNHEFIPFGIGRRMCAGMLWASEVIHLVLPRLIHGFDMKAASANGKVDMAEMAGMVICFKKTPLEVMVNPRE
What is the function of this protein?
Cytochrome P450 involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine (PubMed:25485687, PubMed:27378283, PubMed:29610307).  Converts (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine to (13S,14R)-13-O-acetyl-1,8-dihydroxy-N-methylcanadine (PubMed:25485687, PubMed:27378283).
What are the official names of this protein?
(13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine 8-hydroxylase CYP82X1, Cytochrome P450 82X1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RGYR1_SULTO
Sequence: MLKVYYTFGCPNCGGPIDDEHLLAGVPCSKCLPGRVENLDYRVIYDLLVKNSTLKGYAEYFYDNETFEEIVRIFKRVIGNEPWNLQKYWIKRLAKSESFSLSAPTGLGKTTTLLVYSLFFSNTTLYVVPTNSLKDQICERLRNMGAKVSCNDVKEEYINVATFNRILRHYDNYVSLQPKLVIVDDSDMILKSGKTTEVMAKILGISEEIFQYAISLIRLKRILKFNEDDKELKNKIVELEYKIGSWKPFVQFLVASATLRPKGIKQQALRTLIGFEPSTIQTYLRNIADLYYQGVDIEAILDKISDNGGLLLVSKEYGREKMLELKEIIEKRGYSTGLAISGRKFLNKFTEGKIDYLIGSASYYGVAVRGLDEPKRLKYVIFYGIPKIRLNLTDALNNPSLIVKIGELLNIDVKDIRRKLLFLSPPEFQILRYSLMKDEELSGKLKDIKVNLINIKEKIWDVLKSDNIKKLKADTFLVTENNGKYYVYIPDTVTYIQASGRSSRIISNGLTFGISIVLVDNIDLLDILSQKLKKIIPNFMFKNINEVDIRELKSLAVSSREVSTSQKKKINIKTILLIVESPTKAKTIARLFGRPSRREVHGIPVYETIILVNDEILITNIIATKGHITDLTTENIGYYGVEVGNNEFNAYYSPIYKCYNCGKTFTIKSNTCPYCGSVFISSSEKVVSALRKLSTEVDEIYIASDPDQEGEKIAYDVAMLISPYNKNIYRIKYHEITRNGILNAILNKGKINMNLVKSQIVRRIEDRWIGFELSLALKSMFYERNHGSGRVQGPVLSWIVERTKEYKKNYGWILYIKLGDYAIKKFFRIKEEANKFIEKLNIKINLISERKEIQNPLPPFTTDSLLMDAYDKLGIGSQIVMKIAQDLFESGLITYHRTDSTHVSALGISIAKEYLESKNLNDSFSGRSWGNEGTHEAIRPTSSMDTESLIKDIEDNPNKYFIKFTKYHLRIYDLIFRRFIASQMKPAEVTYSKFEIFINGEKLEVELPTKISGGFSIIYPLKTYVVSEKYSTYLTKGSIIPLFTYAEIIKNMKEKEIGRPSTYAKTISALIRHGYVVESKRKALLIATNKGIKAYEFLSSCCSDLISENRTKLLLQKIDKIANGDVNVDYVLEDLHKEITQISGKLVNSLKLDTNV
What is the function of this protein?
Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process.  It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue.  May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
What are the official names of this protein?
Reverse gyrase 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
Protein: NETR_GORGO
Sequence: MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPPGPHYPSYYLPTQQRPPRTRPPPPLPRFPRPPRALPAQRPHALQAGHTPRPHPWGCPAGEPWVSVTDFGARCLRWAEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPVYWSNVRCRGDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCPKSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASANHFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSYHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDSSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRTLQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL
What is the function of this protein?
Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.
What are the official names of this protein?
Neurotrypsin, Serine protease 12.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVD_ECOHS
Sequence: MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDRIIKLDLVDAMIQGADPKVSDSQSDQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVKNVLGLTLPQTLEQYDVMLTQDDAVKNMFRAGPAGIRTTQAFSQDCRWDSLDDDRANGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGSIGLIEDGDLIAIDIPNRGIQLQVSDAELAARREAQEARGDKAWTPKNRERQVSFALRAYASLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: NU3M_PONPY
Sequence: MNFVLALTINTLLALLLMILTFWLPQLNPYMEKSDPYECGFDPAYPARIPFSMKFFLVAITFLLFDLEIALLLPLPWALQTTNLPLMTTSSLMLIIILALGLTYEWSQKGLDWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: KBTBB_HUMAN
Sequence: MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEGAATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASPEEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDVRGVLIPFALSLPEKPPRGEQGAP
What are the official names of this protein?
Kelch repeat and BTB domain-containing protein 11, Chronic myelogenous leukemia-associated protein, Kelch domain-containing protein 7B.
Protein: FRDD_HAEI8
Sequence: MVDQNPKRSGEPPVWLMFGAGGTVSAIFLPVVILIIGLLLPFGLVDAHNLITFAYSWIGKLVILVLTIFPMWCGLHRIHHGMHDLKVHVPAGGFIFYGLATIYTVWVLFAVINL
What is the function of this protein?
Anchors the catalytic components of the fumarate reductase complex to the cell membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit D, Quinol-fumarate reductase subunit D, QFR subunit D.
What is the protein family that this protein belongs to?
Belongs to the FrdD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.