PharMolix/UniProtQA huggingface dataset:
Protein: GRPE_HELP2
Sequence: MKDEHNQEHDHLSQKEPEFCEKACACKEQQNEEMQEASEKECEIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAYKSAAEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAKND
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM_BACAN
Sequence: MNTKEISKVVDLVRESNPLVHNITNVVVTNFTANGLLALGASPVMAYAKEEVAEMASIAGALVLNMGTLRPDEVEAMLLAGKSANRNDVPVLFDPVGAGATSYRTEVARHIPAEIELAIIRGNAAEIANVINEKWEIKGVDAGAGNGNVVSIAKQAADELNTVAVITGKEDVVTDGERTIVIRNGHSILTKITGTGCLLTSVIGAFVAVEKDYVKAAVAALTFYGVAAELAAAKTVEKGPGSFQIEFLNQLANTTSGDIEKYGKIEVI
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: RESA_GEOKA
Sequence: MKKQQRLVMRTAILLVLLAAIGYTIYTNFFTEKTAVAVGSTAPDFVLTDLKGHEHRLSDYRGKGVFLNFWGTWCKPCEREMPYMNELYPIYKKQGVEILAVNVGEPKLSVEKFAERFGLTFPIVIDRQDQVLNAYNVGPLPTTFLIDKNGEVKQIITGTMTKEDIERHLESIKP
What is the function of this protein?
Thiol-disulfide oxidoreductase which is required in disulfide reduction during c-type cytochrome synthesis.  May accept reducing equivalents from CcdA, leading to breakage of disulfide bonds in apocytochrome c; following this reduction heme can be covalently attached.
What are the official names of this protein?
Thiol-disulfide oxidoreductase ResA.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. ResA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=The thioredoxin-like motif is exposed on the outside of the membrane.
Protein: CAPP_ECO5E
Sequence: MNEQYSALRSNVSMLGKVLGETIKDALGEHILERVETIRKLSKSSRAGNDANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPELSEDTIKKAVESLSLELVLTAHPTEITRRTLIHKMVEVNACLKQLDNKDIADYEHNQLMRRLRQLIAQSWHTDEIRKLRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVEFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIQVLVSELSMVEATPELLALVGEEGAAEPYRYLMKNLRSRLMATQAWLEARLKGEELPKPEGLLTQNEELWEPLYACYQSLQACGMGIIANGDLLDTLRRVKCFGVPLVRIDIRQESTRHTEALGELTRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWQPSAETREVLDTCQVIAEAPQGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNANDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEITVSSLSLYTGAILEANLLPPPEPKESWRRIMDELSVISCDLYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFAKADLWLAEYYDQRLVDKTLWPLGKELRNLQEEDIKVVLAIANDSHLMADLPWIAESIQLRNIYTDPLNVLQAELLHRSRQAEKEGQEPDPRVEQALMVTIAGIAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: DEOC_STRPQ
Sequence: MEVKDILKTVDHTLLATTATWPEIQTILDDAMAYETASACIPASYVKKAAEYVSGKLAICTVIGFPNGYSTTAAKVFECQDAIQNGADEIDMVINLTDVKNGDFDTVEEEIRQIKAKCQDHILKVIVETCQLTKEELIELCGVVTRSGADFIKTSTGFSTAGATFEDVEVMAKYVGEGVKIKAAGGISSLEDAKTFIALGASRLGTSRIIKIVKNEATKPDSY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDH_STRP6
Sequence: MTATKQHKKVILVGDGAVGSSYAFALVTQNIAQELGIIDIFKEKTQGDAEDLSHALAFTSPKKIYAADYSDCHDADLVVLTAGAPQKPGETRLDLVEKNLRINKEVVTQIVASGFKGIFLVAANPVDVLTYSTWKFSGFPKERVIGSGTSLDSARFRQALAAKIGVDARSVHAYIMGEHGDSEFAVWSHANVAGVGLYDWLQANRDIDEQGLVDLFISVRDAAYSIINKKGATFYGIAVALARITKAILDDENAVLPLSVFQEGQYEGVEDCYIGQPAIVGAYGIVRPVNIPLNDAELQKMQASANQLKAIIDEAFAKEEFASAAKN
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBA_THAPS
Sequence: MIATLERREGVSLWERFCAWITSTENRLYIGWFGCLMFPTLLTATSCFIIAFIAAPPVDIDGIREPVAGSLLYGNNIISGAVIPSSNAIGMHFYPIWEAASVDEWLYNGGPYQLIVLHFLLGVASYMGREWELSYRLGMRPWIFVAFSAPVAAASAVFLVYPIGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHMAGVAGVFGGSLFSAMHGSLVTSSLIRETTENESTNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRALHFFLALWPVLGIWLTAMGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRADLGMEVMHERNAHNFPLDLASGDVLPVAFTAPAVNA
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL20_METSB
Sequence: MARVKRGVTSHAKHKKTLEAAKGFYGRRKNTIRAAKAAVDRSMQYATRDRRAKKRVFRALWIQRLNAAVRECGLTYSRFIDGLAKAGVAVDRKVLSDLAITQPEAFKAIVDKAKSALPA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: FSX1_HALS0
Sequence: MKNGLKASVVALFFLLAASSASAATNSVDTVTYESNSDFFDGQVLQVGYTSNFATDKINVYLSESKIESETGAVADEPITFDVSHQNTYAKYPTQDTGLESITGWDAVKKTVSSKQELWDWTTTNCVDTNDAGTFTVDGYGTTDVDARANRWFDTWTGQYKYTIYCWQRNDYYGAVADIGSPDEVFRTEWRLQAGDKNPQTAVITNGDGGTGVTSNLGRYAKVSWEGSLSTGENPPLVDDEYALHSNDYEGGWRVISESRYSSYQSFVQNNADDLLGEWGAGLTTESHIESEMNGKAEEAASEFTESPLSDSEILDSSFQNGAFKLDMERSLMYPEFSVYVDAGENGYATISKPVGKPEIVSTSGAEFGELGQGTISVEAENVGDSEGSFSARTDSCGEYFSGNSLQDTQRVSPGGTASFDFRVTFTSTSMTQSEFSDQCEVVVEDTGSGNEVSASVSVTATQEDECTEGDETKKEKQVNGETVDVIMSCTNGLKLEEDEVCSADEEARYIDDDVQYECRDKDSPPGGGGGDPWTIPGLGWQLDTPFGGMEKALSGNAGALTWAQLLLSFIGFLAGFALVGVKLGKMVDGLATEFIPLSDAVVRLGIGLVGGGMAFMAVYQLVTNPLGFLLTVVGLLLTGYLYLKGTTPDINL
What is the function of this protein?
Exhibits fusogenic activity (PubMed:35794124).  Mediates cell-cell fusion in mammalian cells (bilateral fusion) (PubMed:35794124).
What are the official names of this protein?
Fusexin 1, HQ22Fsx1.
What is the protein family that this protein belongs to?
Belongs to the HAP2/GCS1 family. Fusexin 1 subfamily.
Protein: NADK_RICPR
Sequence: MNINKIALIYNKNSKHLAIIEEIKKLYNYCKIEEAEVIIIIGGDGELLHNIHRYMHLNIPFYGLNLGSLGFLMNPLDTKKLLQNIYESTVSILHPLLMQVEDTSGQIYKALAINEVSIFRKTNQVAKFRIDVNGVERMSELVADGALVATPAGSSAYNLSAGGPILPLASNMLCLTPICSFRPRRWHGALLLSTDTIKFEILNITKRPVNATADFQEFNNITRVTVKSTKDKYIKLLFNKNHTLEDRIIKEQFGE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB2A_DICDI
Sequence: MYSFLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDNKAIKLQIWDTAGQESFRSITRSYYRGSAGALLVYDITRRDTFNHLTCWLKDARSYANSNMTIILIGNKSDMESKRAVSYEEGRQFADENGLIFLETSAKTASNVEEAFVNTASKIYEKIQKGDFDINNESFGIKLGAPTSKQDGTDQKPAGGGCCK
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between active GTP-bound and inactive GDP-bound states.  In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.
What are the official names of this protein?
Ras-related protein Rab-2A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: ADH_MORSE
Sequence: MKAAVLHEFGQSLQIEEVDIPTPGAGEIVVKMQASGVCHTDLHAVEGDWPVKPSPPFIPGHEGVGLITAVGEGVTHVKEGDRVGVAWLYSACGHCTHCLGGWETLCESQQNSGYSVNGSFAEYVLANANYVGIIPESVDSIEIAPVLCAGVTVYKGLKMTDTKPGDWVVISGIGGLGHMAVQYAIAMGLNVAAVDIDDDKLAFAKKLGAKVTVNAKNTDPAEYLQKEIGGAHGALVTAVSAKAFDQALSMLRRGGTLVCNGLPPGDFPVSIFDTVLNGITIRGSIVGTRLDLQESLDMAAAGKVKATVTAEPLENINDIFERMRQGKIEGRIVIDYTM
What is the function of this protein?
Psychrophilic alcohol dehydrogenase that exhibits a wide range of substrate specificity, oxidizing mainly primary and secondary aliphatic alcohols, utilizing NAD(+) as a cosubstrate.  In vitro, shows highest reaction rates for ethanol as a substrate and gradually decreases its reaction rates as the length and branching of the carbon chain of the alcohol substrates increase.  To a lesser extent, is also able to reduce aldehydes and ketones.  Do not catalyze the further oxidation of aldehydes to carboxylic acids.  Cannot use NADP(+) instead of NAD(+).
What are the official names of this protein?
Alcohol dehydrogenase, ADH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: ALB32_CHLRE
Sequence: MALQMKQSPSMGVRRASQPVLPPRPIVHRGVGSVSRRPAVVVKASLLDAASAASAVDAVHHATQLYTLAEGGPIDVLAQFFEFVLQTLDEGLESAKIPYSYGFAIIALTVLVKVATFPLTQKQVESTLSLQALQPRVKELQAKYADDPENLQLETARLYKEAGVNPLAGCFPTLATIPVFIGLYNALSNAAKEGLLTEGFFWIPSLGGPTTIGGGLEWLVPFENGAPPVGWANAAAYLVMPVLLVASQYASQKIISSQNNQDPSQQQAQAILKFLPLMIGWFSLNVPSGLTLYWFVNNLLSTGQQLYLKATVKVNIPEAIKAPATAGSSTPIVKPKEERVKKVTGKELGSRKKRRNDDGEEVEDVEVEVVSSGSSSSSGSNGASGRKGEKFRALKAREAAAKAASTVSAGAGGSEEGKDNSA
What is the function of this protein?
Required for the insertion of some light-harvesting complexes (LHC) proteins into the chloroplast thylakoid membrane.  Essential for the assembly and activity of LHC I and II.  Its function is probably partly distinct from that of ALB3. 1.
What are the official names of this protein?
Inner membrane ALBINO3-like protein 2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC (TC 2.A.9.2) family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RPOZ_STAES
Sequence: MLNPPLNQLTAKVNSKYLIATTAAKRARELDERRETALLDQYHSSKPVGKALEEIADGKIEPVVPKEYLG
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: GPMA_STRMK
Sequence: MTRKLVLLRHGQSQWNLDNRFTGWVDVDLTEQGRREAAAAGRLMREEGLQFDVAHTSVLKRAIHTLQGALAELEQDWLPANKSWRLNERHYGGLQGLDKAETAAKHGEEQVKVWRRSYDIPPPPMELEDPGHPIHDRRYAGLDRNALPGTESLATTLDRVLPYWHDAIAPQLKDGKTVLVTAHGNSLRALYKYLNNVSREEILELNIPTGIPLLFELNDDLTVQSFRYLGDPEAARKAAEAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: SODL_VACCT
Sequence: MAVCIIDHDNIRGVIYFEPVHGKDKVLGSVIGLKSGTYSLIIHRYGDISQGCDSIGSPEIFIGNIFVNRYGVAYVYLDTDVNIFTIIGKALSISKNDQRLACEVIGISYINEKIIHFLTINENGV
What is the function of this protein?
Virion protein with no enzymatic activity.
What are the official names of this protein?
Cu-Zn superoxide dismutase-like protein.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: THII_SALNS
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALAQYREQLEGKTFCVRVKRRGKHEFSSIEVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKVDDGQMGVVLKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAIKAKIEAEEENFDFSILDKVVEEANNVDIREIAQQTQQEVVEVETVSGFGPNDVILDIRSVDEQDDKPLKVEGVDVVSLPFYKLSTKFGDLDQSKTWLLWCERGVMSRLQALYLREQGFANVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRI_VIBPA
Sequence: MAKETQLQVEAIKNGTVIDHIPAQIGIKVLKLFDMHNSSQRVTIGLNLPSSALGHKDLLKIENVFINEEQASKLALYAPHATVNQIENYEVVKKLALELPEKINNVFECPNSNCISHNEPVESSFKVFEKKEEIRLKCKYCEKVFSREIVTER
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: VPX_HV2UC
Sequence: MDPRERVPPGNSDEETIGEAFDWLERTITELNRVAVNHLPRELIFQVWQRCWAYWREEQGMSSSYTKYRYLLLMQKAMFVHYTKGCRCLQEGHGPGGWRSGPPPPPPPGLA
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells.  Targets specific host proteins for degradation by the 26S proteasome.  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1.  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1.  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein: PLSX_STRA1
Sequence: MKKIAVDAMGGDYAPKAIVEGVNQAISDFSDIEVQLYGDQKKIEKYLTVTERVSIIHTEEKINSDDEPAKAVRRKKQSSMVLGAKAVKDGVAQAFISAGNTGALLAAGLFVVGRIKGVDRPGLMSTMPTLDGVGFDMLDLGANAENTASHLHQYAILGSFYAKNVRGIEIPRVGLLNNGTEETKGDSLHKEAYELLAAEPSINFIGNIEARDLMSSVADVVVTDGFTGNAVLKTMEGTAMSIMGSLKSSIKSGGVKAKLGALLLKDSLYQLKDNMDYSSAGGAVLFGLKAPIVKCHGSSDSKAVYSTLKQVRTMLETQVVDQLVDAFTDE
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: ACPS_HALH5
Sequence: MIIGTGIDIVELERIQSMVEKHPRFVKKILTENEQEVFARLSRRRRLEYIAGRFAAKEAFVKAVGTGISAEYGWHDLEVLSDERGKPVLSVNLDATIHVSISHSQSYAIAQVILERLSS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
Protein: Y1278_THEKO
Sequence: MAEDIEEIRKRKLMELQKKYLEQQKAQEEALKREMELEAQLEAIMRKILTPEARERLGRVKLVKPELARQVELLLVQLYQAGQIRERIDDAKLKRILAEIDARTRRDFKIKW
What are the official names of this protein?
DNA-binding protein TK1278.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: VIF_HV1B1
Sequence: MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: GPDA_WOLWR
Sequence: MAISILGAGAWGTAIAISLGSKKDVILWTRNETTFESINGKRESDKLPGCRISDNVSVKLAIEDTINASVTILAVPTQSLRKVCQQLHNCNLKKDVAIILACKGIEKSTLKLPSEIVNEILPNNPIAIFSGPSFAVEVARKLPYSMVLACQNNTLGSKLVSELQQENVKLEFSNDIIGVQICAALKNVFAIACGIVLGSKLGFNAHAALITKSMSEIKALYSAKIGDGSVDINTLLGPACLGDLIMTCTSLNSRNLSFGFKIGNSDNGFNVQQILSEGKSVIEGFSTAESIFNLAGKLKIKMPICEAVYRLLYESASIEDTISVLIS
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y274_HELPJ
Sequence: MRDFDFSFNHKACEGCGAKCCVGESGYIFVTIQEMQQISAFLKLELEEFSQKYVKKVGYKFSLLEKDAKDLGLACVFLDLETKKCQIYSARPKQCQTFPFWESVKTFSKEQKEAFCQSCPGITQKTKETKVR
What are the official names of this protein?
Uncharacterized protein jhp_0259.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0661.
Protein: MSP77_CAEEL
Sequence: MAQSVPPGDIQTQPGTKIVFNAPYDDKHTYHIKVINSSARRIGYGIKTTNMKRLGVDPPCGVLDPKEAVLLAVSCDAFAFGQEDTNNDRITVEWTNTPDGAAKQFRREWFQGDGMARRKNLPIEYNP
What is the function of this protein?
Central component in molecular interactions underlying sperm crawling.  Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
What are the official names of this protein?
Major sperm protein 77/79, MSP.
What are the subcellular locations of this protein?
Cell projection, pseudopodium. Cytoplasm, cytoskeleton.
Protein: DNLJ_FRATF
Sequence: MTPNEFFSIKYHILAKAELKAYIDKLADYLSQQSYLYHTLDKPIISDSDYDKLFRLLQDLVNDNPQFKPINSVLDRVGGEVLAGFETIKHKKKMTSLANVFSLEELRDFYDKIEYDIELECEPKMDGLAISIFYKNGKFDYAVTRGDGIQGEKVSENVKTIRNVPLKLNTSNPPEELEVRGEIILDKQSFLSLNEYMQTHENKTFANPRNAAAGSIRMLDSKVVAKRPLKLYSYGIGYFSKDFVYPETQFELMQLLQSFGFTISDNMFLAKNFSEVEEYHHKMSHQRADLAYDIDGLVFKINNIKLQDTIGYTARGPKWAIAYKFPAEEVESEVLNVEFQVGRTGAITPVARLKPVAVGGVIVSNATLHNINEIKRKDIRVGDRVIVRRAGDVIPEVVKSLPQYRKSDAQIVEMPTNCPVCDSKIENVNDQAIYRCTGGWHCQAQTTERLKHFVSRKAMDIDKLGAKLIEQLVAANLIKYPADIYKLNFEQLTGLERMAAKSSQNVLDSITKSKEPSLARFIFAIGIKDIGEVSSDALANHFGSLESFRDAKFEELIEINYIGEIIANNIVSFWHDSLNIKIVEEFLAIGIKIQNPVKVEHAYNESFTGKTVVITGSFENYGRTELTQLLKSIGAKVTSSVSKKTDMVICGDNAGSKLTKAQELGVEVILEDNLKDLL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PUS10_THEPD
Sequence: MSTGTSASYKRDNAFYALDKVERILLDGYSLCDACTGRLFGLRGYGLSNTERGRALKTLLIMKAFQASPRQADLELLRVLARTGFEPARELLKKLSGEDVEVKACSICEGLTGRYYELALRAVEEAKSYEFNTFEVGVRIDAEVIRREEELWRRYGLESAESIRNEASREVGKIISKLTGKEYSRNNSELLIIVDLSAGAIELHPAPVFVYGRYRKYARGLPQNPWPQPDERIKFNTSIEELIVKPALELFEAEKAKFHAAGREDIDVRTLGTGRPFVLEIKKPRKRNIDLKVLAEKINSGAGGLIEVLDLAYTDRKTIKKLKSLASIAKKAYVARVKFEKPVDDEKLAEISKVFSNAVINQRTPTRVLHRRVDKLRKKIVYRLEARKISQDEVEFYLETQGGFYVKEFIHGDNGRTTPSIAEFLGNNVLSIELDVVSIEETAA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase Pus10, tRNA pseudouridine 54/55 synthase, Psi54/55 synthase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase Pus10 family.