PharMolix/UniProtQA huggingface dataset:
Protein: GLYA_LACGA
Sequence: MNYGEKAPALWDAIKNEEKRQEDTIELIASENIVSDAVREAQGSVLTNKYAEGYPGKRYYGGCQYIDQVEQLAIDYAKKLFNAEYANVQPHSGSQANMTVYNALLKPGDTILGMGMDAGGHLTHGSKVNFSGKIFNSVSYDLNPETEELDFEKIRQIALENKPKLIIAGASAYSRIIDWQKFREIADEVGAYLMVDMAHIAGLVATGAHPSPIPVADVVTTTTHKTLRGPRGGMILSNNKKLGKKIDSALFPGTQGGPLEHVIAAKAQAFYEDLQPEFSTYIEQVVKNAQAMADEFKKSENIRVVSGGTDNHLMIVDITKTGVTGKDAQNLLDSVNITTNKESIPGDTRSPFITSGLRIGTPAITSRGFKENDAREVARIIIKVLDNPEDKDVLTEAKSSVKSLVDKHQIK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCP_ECOLI
Sequence: MTTMNPFLVQSTLPYLAPHFDQIANHHYRPAFDEGMQQKRAEIAAIALNPQMPDFNNTILALEQSGELLTRVTSVFFAMTAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVWQRRESLGLDSESIRLVEVIHQRFVLAGAKLAQADKAKLKVLNTEAATLTSQFNQRLLAANKSGGLVVNDIAQLAGMSEQEIALAAEAAREKGLDNKWLIPLLNTTQQPALAEMRDRATREKLFIAGWTRAEKNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQMAKTPEAALNFMREIVPAARQRASDELASIQAVIDKQQGGFSAQPWDWAFYAEQVRREKFDLDEAQLKPYFELNTVLNEGVFWTANQLFGIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDSKSGGAWMGNFVEQSTLNKTHPVIYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLFARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRNASLFNKGYEMSELLSAALLDMRWHCLEENEAMQDVDDFELRALVAENMDLPAIPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGLRFREAILSRGNSEDLERLYRQWRGKAPKIMPMLQHRGLNI
What is the function of this protein?
Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides.
What are the official names of this protein?
Dipeptidyl carboxypeptidase, Peptidyl-dipeptidase Dcp.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP5_ROTWI
Sequence: MSLSIDVTSLPSISSSIFKNESSSATSTLSGKSIGRSEQYISPDVEAFNKYMLSKSPEDIGPSDSASNDPLTSFSIRSNAVKTNADAGVSMDSSTQSRPSSNVGCDQLDFSLNKGINVSANLDSCISISTDHKKEKSKKDKSRKHYPRIEADSDSEDYVLDDSDSDDGKCKNCKYKKKYFALRMRMKQVAMQLIEDL
What is the function of this protein?
Plays an essential role in the viral genome replication.  Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place.  Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories.
What are the official names of this protein?
Non-structural protein 5, NSP5, NS26.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP5 family.
What are the subcellular locations of this protein?
Host cytoplasm. Note=Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RALYL_XENTR
Sequence: MTGKTQTSNVTNKNDPKSINSRVFIGNLNTGIVKKADIEAIFAKYGKIVGCSVHKGYAFVQYISERHARAAVTGENSRIIGGQPLDINMAGEPKPYRPKLGTKRPLSTLYSAYDFDYDYYRDDFYNRLFDYGHGRVPPPPRAAIPLKRPRMSVPTTRRGKGVFSLKGGSRSASGGSSSSGSKLKSDELQTIKKELTQIKTKIDSLLGRLEKIEKQQKAEAGAQKKQTEDHTDSVQEECKSETADNSTEEHIEGGHDADGEEMTDGIEEDFDEDGSNELMENHISDIEDTSN
What are the official names of this protein?
RNA-binding Raly-like protein.
What is the protein family that this protein belongs to?
Belongs to the RRM HNRPC family. RALY subfamily.
Protein: G6PI_BURMS
Sequence: MTLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTDATLALLVRLAREAGVEARRDAMFAGETVNPTEGRAALHTALRANAPDAPFQAQVAAERAKMARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALHHVATPDIATHFVSNVDGADLARVLERIDPEETLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSANPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFRTAPLERNLPVLQGLVGIWYRNFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDGAFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIAVLTPEHPLASHHPKLLANCFAQSEALMLGRTLDEARKIAGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEHKVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_PROA2
Sequence: MQRKDALKEIARLRDELNRHNYRYYVLAQPEISDYAFDQELERLIALEKAFPDLVTPDSPSQRVGGEITKEFPTVTHRQPMRSLSNTYSLEEVEEFYARVLKLLPEEAGENPEFVAELKFDGVAVSLLYRDGFLVQGATRGNGVEGDDITPNIRTIGSVPLQLRGGAAMAAEQYGGREIEVRGEVFMRKDDFAALNEGRPEEEQFANPRNATAGTLKLQDSAEVARRKMMFVAYYLTDPQCRSMQHVQRLQRLEEMGFYTGGHYSTCRSFDEIRDFIGRWEVDRLTLQYDIDGIVLKLNNPAFWDELGATSKSPRWAIAYKYPAEQAETVLNDVVFQVGRLGTITPVAELEAVRLAGTTVKRSTLHNFDEIRRLDVRIGDRVVIEKSGEIIPKVIRVVPGTRREDSSEIAIPSHCPVCGTALLHPENEVSWYCPNSQSCPAQVKARILHFASRNAMDIKSLGESLVEQLVHNGLVADSGDLYRLTADEVSHLDRMADKSAMNLLKAIEKSRTREYERVLYALGIRHVGLATARELAAAYHSIDLLASAALEELSCVADIGPVIAQSVHDFFRNPDALALVEKLRTAGLRLAASAPKALVNRNFEGMKVIFTGTLERHSRDDAAALVAQRGGKEVKSLSRKTDLVVAGKDPGSKLQKALKLGVRVIGEEEFEAMLF
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: TRUB_PICTO
Sequence: MSNLNGFIVVDKPKGPTSHQIDSWIRDITGEPRVGHIGTLDPGVSGVLVMALGKATKLIDIVHRESKEYVSVLRTYDKYDHDSIKSVFKEFTGKIYQIPPVRSAVSRELRIREIYNLELLEMDEKFVLFKVCCESGTYIRTLCTDIGYVLGSGGQMAELRRTRTGPFDESMCHTLQEVSDAFKLKSMGNEKLFKNIFIPMDFIFIKYPKVIVKETALKNIAHGSDIYPAGIHAITGSPKKGDVVAVYTEKNELVATGTMMVNADEIYDLKVIDIDNVLIETGDNDGKDSLVRKDNRWKDIPVQKPERKLHGNLQGSQEWKDTGNRGNPKRGGTGSKGFSSGFRKRKAKR
What is the function of this protein?
Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
Probable tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
Protein: MATK_ROSCN
Sequence: MEEFQGYLELYRSQQHDFLYPLIFREYIYALAHDRGLNRSVLLDNVGYDKKSSLLIIKRLISRMYQQNHFIISVNDSNQNKFFGYNKNLYSQMISEGFAVIVEIPFSLRLVSSLEETETVKSYNLRSIHSIFPFFEDKFPHLNYASDVLIPYPIHLEILVQTLRYCVKDPSSLHLLRLFLHEYYNWNTLITPKKSIFAKSNQRLFLLLYNSYVCEYESILLFLRNQSNHLRLTSSGILFERIRFYEKIKYPVEEVFANDFPATLWFFKDPFIQYVRYQGKSILASKDTPLLMNKWKYYLVHFWQCHFYVWSQPGRIHINQLSKHSFDFLGYLSSIRPNISVVRSQLLENSFLMDNAMKKLDTLFPIIPMIGSLAKVKFCNTSGHPISKSSWADSSDSDIIDRFVRIGGNLSHYYSGSSKKKSLYRIKYILRLSCVKTLARKHKSTVRTFLKRLGPKLLDEFFTEEEQIFSLLFPRTSSTLKRFYRGRIWYLDILCINDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KU_BACSU
Sequence: MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDKDIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQEHEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTIRSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELTAKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRRPNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS
What is the function of this protein?
With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity.  Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA.  Recruits and stimulates the ligase activity of LigD (By similarity).  Probably involved in DNA repair during spore germination.
What are the official names of this protein?
Non-homologous end joining protein Ku.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic Ku family.
What are the subcellular locations of this protein?
Spore core. Note=Expressed in the center of the spore core, presumably with the nucleoid.
Protein: UBP40_MOUSE
Sequence: MFGNLFEEDYSSVSSSQYGRGKKLKTKGLEPPAPREFTNLSGIRNQGGTCYLSSLLQTLHFTPEFREALFSLGPEELGSLEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTIDLTDSFGWTNDEEMRQHDVQELNRILFSALETSLVGTSGHDLIHRLYHGTIVNQIVCKECKNISERQEDFLDLTVAVKNVSGLEDELCNMYVEEEIFDYDNLYHCGTCDRLVKAAKSAKLRKLPPFLTISLLRFNFDFVKCERYKDTSCYTFPLRINLKPFCEQSELDDMEYMYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQCQEEISDTNVNVKAPQSEEEANDPLVVLKTILLQEEANQIPVDQLGQKLLKKTGISWNKKYRKQHGPLRKFLQLHPQIFLLSTDESTVSLLRNHLTQAPSDLQSCEQILHTLASESPGLNDDTSCPHWFDINDSKVHPIREKDITQQFQGKESAYMLFYRKATLQRPPEARANPRYRVPCHLLKEMDAANILLQMRRAECDSANSTFELHLHLGPHYRFFNGALHPAVSETESVWDLTFDKRKTLGDLRQSIFQLLECWEGDMVLSVAKRVPAGLHVYHTLDGDDLTLCEAEVADGEDIFVWNGVEVGGVQIQTGFDCEPLLLNILHLELSGEGSKCEQLVESPHVFPANAEVGAVFTALGTPAGAILMNSVESADGECWTAVPKEDMKKTFREQGLRNGSLILVQDSDSDNNSLLPKQGRWTNSMNELNWLQVKNFCQSESEEKQVQIAVTMHTVVFDIRIKAIKELKLMKELAENSCLRPIDRNGKLLCPVPDSSTLEEAEVKMGSSVGLCLGKAPTSSQLFLFFALGTDIHPGAEMDIIVEETLSVRDCLKIMLEKSGQQGEIWHLRKMDWCYEAGEPLCEEDATLKELMIRSGDTLLLTEGKLPPPGHLKMPIWWYQPARLSGHCESRDHLNCAFSQDSTWRAAPTQGAPGPEPAEVSLLYLGDMEISEEATLVELKSQALALPSVSKLAVQSTALLRVWTVESKRPSRLLRTNWRQLKEYRLGRRAELCLELLQKEEDLGPRDVLLRTQLRIPGERAYSLATDLIWDTTRGWTAGSLRQRVADFYSLPVEKIEIAKYFPEKFEWLPISSWNQQVAKRKKKKNQDTLQGGPYYLKDGDTIGIKNLLFDDNDDFSTIRDDIGKENQKRLALEKKKSREVHRAQSSDLFSNAGVPARFRGPEASLSIHVASFR
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 40, Deubiquitinating enzyme 40, Ubiquitin thioesterase 40, Ubiquitin-specific-processing protease 40.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: SYN_DEIDV
Sequence: MISNIRDLKQHVGETVTLQAWLTDKSGKGKIQFLKLRDGSGFVQATVFKNDVEEEVFESAKRLTQEQALTLTGEVRADERAPGGVELSVRRLSPISENHAEYPITPKEHGIEFLMDQRHLWLRHRRPWAIMRIRDCVQRAIVDFFHSEGFVRFDAPFFTPNAAEGTTELFEIDLFGEDKAYLSQTGQLHAEAGAFAFGKVYTFGPTFRAEKSKTRRHLLEFWMVEPEVAPSNHKQNMDLQERFVSFLVRRALDECTVELEMLGRDLSKLKGAAEGNYPRVTYTEALEIVRQHIENKDLPPNVQEDVQPVEWGDDLGAPHETILGHHFDRPVMIEKYPAAIKAFYMQPDPEDSRVALCDDMIAPEGYGEIIGGSERIHDYDLLKSRIEHEGLPLEAFDWYLDLRRVGSVPHAGFGMGLERVIAWISGIDHIREAIPFPRMLTRMRP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_NITEU
Sequence: MTKFVFVTGGVVSSLGKGIAAASLAALLETRGIRVTILKLDPYINVDPGTMNPFQHGEVFVTDDGAETDLDLGHYERFISTKMTRQNNFTTGQIYESVIRKERRGDYLGGTVQVIPHITDEIKLFIRNGVSDAQVAIVEIGGTVGDIESLPFLEAIRQMSVQLPHHDTCFIHLTLLPYISSAGELKTKPTQHSVKELREIGIQPDVLLCRSDRPLPLEERRKIALFTNVREESVISAIDVDNIYKIPALLHEQMLDEIVCHRLDILARPANLTVWKKLVHALEHPEHEVSIALVGKYVDLTESYKSLSEALIHAGIHTRCKINIHYIDSENIEQHGTGCLTNMDAILVPGGFGKRGVEGKIMAISYARNHRIPYLGICLGMQLAVIEFSRNRLQLENAHSTEFDPDTPYPVLGLITEWRDRCGRVEKRSAQTDLGGTMRLGGQECLLKPHTLAHKIYGADKVIERHRHRYEVNAEFIPQLEQAGMHISGLSAEGDLCEMIELPQSEHPWFVACQFHPEFTSTPRNGHPLFKSYIQAAISFAGQSDRTKLHSRNVQESVTTDSSN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PYRB_BURO0
Sequence: MTTDTTGRAGNPAAAASPDRFRYGFLKGNPQLTKNGELKHLLSIEGLPRSIVNHILDTAEQFVSVTDREVKKVPLLRGKSVFNLFFENSTRTRTTFEIAATRLSADVLNLNINASSTSKGESLLDTINNLSAMHADLFVVRHASSGAPYLIAEHCAPHVHVINAGDGRHAHPTQGLLDMYTIRHYKRDFTKLRVAIVGDILHSRVARSDIHALTTLGVPEVRAIGPRTLLPGGLEQMGVKVFHNLDEGLKGVDVIIMLRLQNERMSGALLPSAQEYFKTWGLTPERLALAAPDAIVMHPGPMNRGVEIDSQVADGPQSVILNQVTFGIAVRMAVMGIVAGNSD
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: GLGB_RHOMR
Sequence: MSWLTEEDIRRWESGTFYDSYRKLGAHPDDEGTWFCVWAPHADGVSVLGAFNDWNPEANPLERYGGGLWAGYVPGARPGHTYKYRIRHGFYQADKTDPYAFAMEPPTGSPIEGLASIITRLDYTWHDDEWMRRRKGPASLYEPVSIYEVHLGSWRHKRPGESFSYREIAEPLADYVQEMGFTHVELLPVMEHPYYGSWGYQVVGYYAPTFRYGSPQDLMYLIDYLHQRGIGVILDWVPSHFAADPQGLVFFDGTTLFEYDDPKMRYHPDWGTYVFDYNKPGVRNFLISNALFWLEKYHVDGLRVDAVASMLYRDYSRKEWTPNIFGGRENLEAIDFIKKFNETVYLHFPEAMTIAEESTAWPGVSAPTYNNGLGFLYKWNMGWMHDTLDYIQRDPIYRKYHHDELTFSLWYAFSEHYVLPLSHDEVVHGKGSLWGKMPGDDWQKAANLRLLFGHMWGHPGKKLLFMGGEFGQHHEWNHDTQLEWHLLDQPYHRGIQLWVCDLNHLYRTNPALWHDGPEGFEWIDFSDRDQSVICYLRKNAGRMLLFVLNFTPVPREHYRVGVPIGGPWHEVLNSDAVAYGGSGMGNFGRVEAVPESWHGRPFHLELTLPPLAALILEPEHG
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: SNX4_MAGO7
Sequence: MGGIDQDNFSNISWQSDRLGAGSSAAHQHGGQESEQPTHNQAEPEPNYTSMIVHGMGLGDEVLECNVSSPLKENDGTKDAFVSYLVTTHTTFADFQKPDASVRRRFTDFVFLFKTLSREYPASAVPPLPDKQRMEYVRGDRFGNDFTSRRAYSLRRFLARCALHPVLRRSAILHTFLESPDWNATMRSRASRSVSMSGTSSGESGNAHYGGGSAGGGSTGGGNSLANSVFDNFADTFINAFTKVHKPDRRFIEVREKSDKLDEDLAHVEKVVARVSRRETDMEADHKDLAEQFQKLIVLEPGVEGPVRAFAASVEDTAQGLRGLREATEQDYLGSLRDLAAYSGALKNLLKAREQKQLDFEQLTEYLNKSSAERDVLASGGYSSGGALAGAGGFIRSKIEDVRGVDHEQSRRERLRKLELRIEELTVEVERAKKTSELFDEEVIREVSDFERIKRIELKRQFGSLAQSHTDFYDATIDVWEKYVKEMEKEGAVAA
What is the function of this protein?
Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells.  Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), autophagy, mitophagy, and pexophagy.
What are the official names of this protein?
Sorting nexin-4, Autophagy-related protein 24.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures. Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures.
Protein: RIMK_AERS4
Sequence: MKIAILSREPRNYSTRRLVEVAQARGHQVEVLDTLRCYMNIASHSPSIHYEGRELESYDAVIPRIGASITFYGTAVLRQFEMMNTMALNSSVAISRSRDKLRAMQLLSRHGIGLPITGYAHSTHDVPDLITMVGGAPLVVKLLEGTQGIGVVLCETHKAAESVIEAFIQTNNNILVQEYIREANGADIRCLVVNGKVVAAMRRQAQPGEFRSNLHRGGTAEAIKISPEERATAVQAAKIMGLDVAGVDILRSARGPLVLEVNSSPGLQGVEAASGKDVAGKIIEFLELKASRKNKPAE
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: COFG_SYNE7
Sequence: MKHFSDQTWRSPQQSAVITYSPAYTLVPTYECFNRCTYCNFRRDPGMDEWLSLSTAQQRLLTVRDRGVCEVLILSGEVHPQSPRRAAWRQRLIELAELALDMGFLPHTNAGPLNRAEMIALQNVNVSLGLMLEQLTPQLQRTVHRAAPSKDPQLRLQQLEQAGELGIPFTTGLLLGIGETSRDRLETLEAIAACHDRWGHIQEVILQPHSPGRQQAIQHPPLAPDELIDCVAIARQVLPTSIAIQVPPNLLTQPQQLADCLGAGARDLGGIVPYDEVNPDYQHHDLDELREALAQQGWQLQPRLPVYPHLVDRLPQRLQTHVAAWLNRFNSQSRSS
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
What are the official names of this protein?
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, FO synthase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofG family.
Protein: PDPR_BOVIN
Sequence: MLPRLLAVVRGPGSCRGWREGSPARGSASATVAPPVALPAQAQVVVCGGGIMGTSVAYHLSKMGWKDVVLLEQGRLAAGSTRFCAGILSTARHLAIEQKMADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINSRLNVIGIPCEIISPKKVAELHPLLNVHDLVGAMHVPEDAVVSSADVALALASAASQSGVQIYDRTSILHVMVKKGQVAGVETDKGQIQCQYFVNCAGQWAYELGLCSEEPVSIPLHACEHFYLLTRPWETPLPSSTPTVVDADGRIYIRNWQGGILSGGFEKNPKPIFTEGKNQLEIQNLQEDWDHFEPLLSSLLRRMPQLETLEIVKLVNCPETFTPDMRCIMGESPSVRGYFVLVGMNSAGLSFGGGAGKYLAEWMVYGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLLYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFIPPDKDLLALEQSKTFYKPDWFEIVESEVKCCKEAVCVIDMSSFTKFEITSTGDQALEILQYLFSNDLDVPVGHIVHTGMLNERGGYENDCSIARLSKRSFFMISPTDQQVHCWAWLKKYMPEDSNLILEDVTWKYTALNLIGPRTVDVLSELSYAPMTPDHFPSLFCKEMSVGYANGIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDLNTLTTPLECGGESRVKLDKGVDFIGRDALLQQRQNGVYNRLTMFILDDHDTDLDLWPWWGEPIYRNGRYVGKTTSSAYGYTLERHVCLGFVHNFSEDTGEEQVVTADFINRGEYEIDIAGHRFQAKAKLYPVPSLLTHKRRKEDVELSDLHGK
What is the function of this protein?
Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.
What are the official names of this protein?
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial, PDPr.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RL15_CAMC1
Sequence: MALEKLTPAAGSTHATKRIGRGQGSGNGKTAGKGNKGQRARKGYNEKRGFEGGQQPLQRRLPKVGFASKFEKPYVINVEKIAAIKELAEISIATIASVHKISKSVTKIKLIGASAKALASKIKDENVSVSGTK
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PDXT_MYCTU
Sequence: MSVPRVGVLALQGDTREHLAALRECGAEPMTVRRRDELDAVDALVIPGGESTTMSHLLLDLDLLGPLRARLADGLPAYGSCAGMILLASEILDAGAAGRQALPLRAMNMTVRRNAFGSQVDSFEGDIEFAGLDDPVRAVFIRAPWVERVGDGVQVLARAAGHIVAVRQGAVLATAFHPEMTGDRRIHQLFVDIVTSAA
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: MSHR_CAPHI
Sequence: MPALGSPRRLLGSLNCTPPATLPLTLAPNRTGPQCLEVSIPDGLFLSLGLVSLVENVLVVAAIAKNRNLHSPMYYFICCLAMSDLLVSVSNVLETAVMLLLEAGVLATRAAVVQQLDNVIDVLICSSMVSSLCFLGAIAVDRYISIFYALRYHSVVTLPRAWRIIAAIWVASILTSVLSITYYNHTVVLLCLVGFFIAMLALMAVLYVHMLARACQHARGIARLQKRQRPIHQGFGLKGAATLTILLGVFFLCWGPFFLHLSLIVLCPQHPTCGCIFKNFNLFLALIICNAIVDPLIYAFRSQELRKTLQEVLQCSW
What is the function of this protein?
Receptor for MSH (alpha, beta and gamma) and ACTH (By similarity).  The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity).  Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (By similarity).
What are the official names of this protein?
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBFA_HUMAN
Sequence: MWAAAGGLWRSRAGLRALFRSRDAALFPGCERGLHCSAVSCKNWLKKFASKTKKKVWYESPSLGSHSTYKPSKLEFLMRSTSKKTRKEDHARLRALNGLLYKALTDLLCTPEVSQELYDLNVELSKVSLTPDFSACRAYWKTTLSAEQNAHMEAVLQRSAAHMRHLLMSQQTLRNVPPIVFVQDKGNAALAELDQLLAVADFGPRDERDNFVQNDFRDPDAPQPCGTTEPTTSSSLCGIDHEALNKQIMEYKRRKDKGLGGLVWQGQVAELTTQMKKGRKRAKPRLEQDSSLKSYLSGEEVEDDLDLVGAPEYECYAPDTEELEAERGGGRTEDGHSCGASRE
What are the official names of this protein?
Putative ribosome-binding factor A, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PANC_ANADE
Sequence: MKTPELITDPAAWQARCTAAREAGTRIALVTTMGYLHEGHLSLMREARRRADAGGRRGLAVGTIFVNPTQFGPTEDLARYPRDLEGDLAKCAAAGLDAVLAPSDPALMFAPGHETWVTVERASQGLDGASRPGHFRGVATVVAKLFNLTRPHVALFGEKDWQQLAVIRAMVRDLAFGIEIVGMPIVREPDGLALSSRNAYLSPDERRRALALSGALAEAREATARGERDAAALRAGARARLEAAGGRVDYVELVHPETLAPVARAEPGTVLLLAASFGTTRLIDNGRLP
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHM4A_BOVIN
Sequence: MSGLGRLFGRGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIEQELQAAKKHGTKNKRAALQALRRKKRLEQQLAQTDGTLSTLEFQREAIENATTNAEVLRTMELAAQGLKKAYQDMDIDKVDELMADITEQQEVAQQISDAISRPVGFGDDVDEDELLEELEELEQEELARELLHVGDEEEEPPVALPSAPSTHLPAEPAPKADEDEAELKQLAEWVS
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.  ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.  The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses).  ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.  When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding.  CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 4a, Chromatin-modifying protein 4a, CHMP4a.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane. Late endosome membrane; Peripheral membrane protein. Note=Membrane-associated. Localizes to large vesicle- like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body (By similarity).