PharMolix/UniProtQA huggingface dataset:
Protein: ENO_STAAT
Sequence: MPIITDVYAREVLDSRGNPTVEVEVLTESGAFGRALVPSGASTGEHEAVELRDGDKSRYLGKGVTKAVENVNEIIAPEIIEGEFSVLDQVSIDKMMIALDGTPNKGKLGANAILGVSIAVARAAADLLGQPLYKYLGGFNGKQLPVPMMNIVNGGSHSDAPIAFQEFMILPVGATTFKESLRWGTEIFHNLKSILSKRGLETAVGDEGGFAPKFEGTEDAVETIIQAIEAAGYKPGEEVFLGFDCASSEFYENGVYDYSKFEGEHGAKRTAAEQVDYLEQLVDKYPIITIEDGMDENDWDGWKQLTERIGDRVQLVGDDLFVTNTEILAKGIENGIGNSILIKVNQIGTLTETFDAIEMAQKAGYTAVVSHRSGETEDTTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELFETAKYDGIKSFYNLDK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: LIVB5_BRUSU
Sequence: MIGTRLPAWTRVLACGVAGLSLMTISAKAEDVITLGASVQLSGPVANTGRYYQDAYNITIDKINAAGGVKVDGKPYKLALKIYDNQSNVNLSVRQYTQLVTTDKVNFLLGPFASNFALADSVISEKYRIPMVQGGGASDEIYSRNFKYIFGTLAPASNYFGSTVEMLKGLDPKVTNVALVYADDSFDISVADGTRKLLKDAGFTIAADEKFATNSTDFTSLISQIKSKNVDAVLVAGHETEVLNFVRQSKSLAFDPKLYSFTVGVPTEDFRKALGKDANYAFGMTAWLPSADLKDRWFGDAAKFETEYKARFNYEPDYHAASGASDVEAFAEAIEKANSLDPQKVRDALASIKFDSLYGPIAFDKQGQINLPQIVVQVQDGKLVEIRGPAGQVNPPQYPMPAWNAR
What is the function of this protein?
Component of an amino-acid transport system.
What are the official names of this protein?
Leu/Ile/Val-binding protein homolog 5.
What is the protein family that this protein belongs to?
Belongs to the leucine-binding protein family.
Protein: EX7L_BACC7
Sequence: MEKQYLTVTALTRYIKTKIEYDPHLQSVWLKGEISNFKNHSRGHMYFTLKDENARIAAVMFAGHNRNIKFRPENGMKVLVKGKISVYEASGSYQIYIQDMQPDGVGNLHLAYEQLKVRLEEEGLFSQVYKKTIPPYAKTIGVITSPTGAAIRDIITTIKRRYPIGNVIVFPVLVQGESAAPSIVQAIRTANEMEGIDVLIVGRGGGSIEELWAFNEEMVARAIFKSEIPIISAVGHETDFTIADFVADLRAPTPTAAAELAAPNIIELQEKVLQRTLRLQRAMRELVHKKEEKLQVLQKSYAFRYPRQVYEQKEEQLDRALEQLVLAKERYIDKKVNQLKQLSFYLEKHHPSQKIMQTKVAVETLQKQLQREMQTLLQTKEFAFVRAAQKLEALSPLKVMMRGYGLVYDEEKQVLKSVKDVSLGDAVSVQLQDGILDCSVSGIEERELNNGK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C561_YERPE
Sequence: MHKKYSCLQIGIHWLVLLLVIIAWSSIELRGFAPRSYQPWMKMIHFSCGIAILVLMMTRILIQLRYPTPPIVPKPSPMIVGLAHVGHWVIYLLFIALPIIGIAILYCRGSSWIAFGLIMPHAEQANFDLADTLKAYHLLLANMSYFVIGLHALAALLHHYVLKDNTLLRMMPKKRG
What is the function of this protein?
B-type di-heme cytochrome.  Catalyzes the oxidation of superoxide to molecular oxygen and transfers the extracted electrons to ubiquinone through the two hemes.
What are the official names of this protein?
Probable superoxide oxidase CybB, SOO, Cytochrome b-561, Cytochrome b561, Superoxide:quinone oxidoreductase, Superoxide:ubiquinone oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b561 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RSMH_SALTO
Sequence: MGELRGAHVPVLLERCLELLSPALDRTGQTGRTVYVDATLGLGGHAEAILTAHPRTMLVGLDRDTEALAHARVRLARFADRVHLEHAVYDELPDVLDRIGHPVVDGILFDLGVSSLQLDAPDRGFAYAQDAPLDMRMDQSRGVTAEEVVNSYSHPELARVLRVYGEEKFASRIASAIVRERDRAPITSSAQLAELVRQAIPAPARRTGGHPAKRTFQALRIEVNRELAALETALPAALDRLAIEGRMVVLSYHSLEDRLTKVALADRVRSKGPIDLPVELPGTGPTFRLLSRGAELPGEAEVAVNPRAASVRLRAAERLDPTQQQRQRTDRERYRRQVRAMHQPGTGSAVRRPVSGDDGTGTDEEGEGHDD
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CO4A4_MOUSE
Sequence: MRCFFRWTKSFVTAPWSLIFILFTIQYEYGSGKKYGGPCGGRNCSVCQCFPEKGSRGHPGPLGPQGPIGPLGPLGPIGIPGEKGERGDSGSPGPPGEKGDKGPTGVPGFPGVDGVPGHPGPPGPRGKPGVDGYNGSRGDPGYPGERGAPGPGGPPGQPGENGEKGRSVYITGGVKGIQGDRGDPGPPGLPGSRGAQGSPGPMGHAGAPGLAGPIGHPGSPGLKGNPATGLKGQRGEPGEVGQRGPPGPTLLVQPPDLSIYKGEKGVKGMPGMIGPPGPPGRKGAPGVGIKGEKGIPGFPGPRGEPGSHGPPGFPGFKGIQGAAGEPGLFGFLGPKGDLGDRGYPGPPGILLTPAPPLKGVPGDPGPPGYYGEIGDVGLPGPPGPPGRPGETCPGMMGPPGPPGVPGPPGFPGEAGVPGRLDCAPGKPGKPGLPGLPGAPGPEGPPGSDVIYCRPGCPGPMGEKGKVGPPGRRGAKGAKGNKGLCTCPPGPMGPPGPPGPPGRQGSKGDLGLPGWHGEKGDPGQPGAEGPPGPPGRPGAMGPPGHKGEKGDMVISRVKGQKGERGLDGPPGFPGPHGQDGGDGRPGERGDPGPRGDHKDAAPGERGLPGLPGPPGRTGPEGPPGLGFPGPPGQRGLPGEPGRPGTRGFDGTKGQKGDSILCNVSYPGKPGLPGLDGPPGLKGFPGPPGAPGMRCPDGQKGQRGKPGMSGIPGPPGFRGDMGDPGIKGEKGTSPIGPPGPPGSPGKDGQKGIPGDPAFGDPGPPGERGLPGAPGMKGQKGHPGCPGAGGPPGIPGSPGLKGPKGREGSRGFPGIPGSPGHSCERGAPGIPGQPGLPGTPGDPGAPGWKGQPGDMGPSGPAGMKGLPGLPGLPGADGLRGPPGIPGPNGEDGLPGLPGLKGLPGLPGFPGFPGERGKPGPDGEPGRKGEVGEKGWPGLKGDLGERGAKGDRGLPGDAGEAVTSRKGEPGDAGPPGDGGFSGERGDKGSSGMRGGRGDPGRDGLPGLHRGQPGIDGPPGPPGPPGPPGSPGLRGVIGFPGFPGDQGDPGSPGPPGFPGDDGARGPKGYKGDPASQCGPPGPKGEPGSPGYQGRTGVPGEKGFPGDEGPRGPPGRPGQPGSFGPPGCPGDPGMPGLKGHPGEVGDPGPRGDAGDFGRPGPAGVKGPLGSPGLNGLHGLKGEKGTKGASGLLEMGPPGPMGMPGQKGEKGDPGSPGISPPGLPGEKGFPGPPGRPGPPGPAGAPGRAAKGDIPDPGPPGDRGPPGPDGPRGVPGPPGSPGNVDLLKGDPGDCGLPGPPGSRGPPGPPGCQGPPGCDGKDGQKGPMGLPGLPGPPGLPGAPGEKGLPGPPGRKGPVGPPGCRGEPGPPADVDSCPRIPGLPGVPGPRGPEGAMGEPGRRGLPGPGCKGEPGPDGRRGQDGIPGSPGPPGRKGDTGEAGCPGAPGPPGPTGDPGPKGFGPGSLSGFLLVLHSQTDQEPACPVGMPRLWTGYSLLYMEGQEKAHNQDLGLAGSCLPVFSTLPFAYCNIHQVCHYAQRNDRSYWLSSAAPLPMMPLSEEEIRSYISRCAVCEAPAQAVAVHSQDQSIPPCPRTWRSLWIGYSFLMHTGAGDQGGGQALMSPGSCLEDFRAAPFVECQGRQGTCHFFANEYSFWLTTVNPDLQFASGPSPDTLKEVQAQRRKISRCQVCMKHS
What is the function of this protein?
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
What are the official names of this protein?
Collagen alpha-4(IV) chain.
What is the protein family that this protein belongs to?
Belongs to the type IV collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A3 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL).
Protein: GYS2_RAT
Sequence: MLRGRSLSVTSLGGLPAWEAERLPVEDLLLFEVSWEVTNKVGGICTVIQSKAKTTANEWGENYFLIGPYFEHNVKTQVEPCEPANDAVRKAVDAMNKHGCQVHFGRWLIEGSPYVVLFDISSSVWNLDRWKGDFWEACGVGIPHDDREANDMLIFGSLTAWFLKEVTDHADGKHVIAQFHEWQAGTGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNQLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEADHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHATYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSNVTVVVFFIMPAKTNNFNVETLKGQAVRKQLWDTVHCMKEKFGKKLYDGLLRGEIPDMNSILDRDDLTIMKRAIFSTQRHSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTQFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHLEPTSPPTTDGFKYPRPSSVPPSPSGSQTSSPQSSDVENEGDEDERYDEEEEAERDRLNIKSPFSLNHIPKGKKKLHGEYKN
What is the function of this protein?
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
What are the official names of this protein?
Glycogen [starch] synthase, liver.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 3 family.
Protein: LTAA_STAHJ
Sequence: MPDSSLSNKGISKNFKIMLVILFLMEFARGMYVLSYVNYLPTVTSIAVAVTSAALSIHFISDAATNFVIGFLLKKFGTKLVLTLGFLLAFISLFLVIWFPTNPIVIILSAIMLGIAVSPIWVIMLSSVEEAQRGKQMGYVYFAWLLGLLVGWAFMNVLVKLHPTRFAFMMSLVVVIAWVLYYFVDIKLTNYNTKPVSEQLGQIVDVMKRHLVLFPGILLQGASISALLPILPTYATKVVGVSTIEYTIAIAIGGAGCAFSMLFLSKIIDKNSKGFMYAVIFTGFILFTAFIFGLSLVTNILIVWIVAIFIGLMYGILLPAWNTFMAGQIDPAEQEETWGVFNSVQGFGSMIGPLFGGLIAQFSNGLNNTFYFSAAIFLVLAIFYGVYFVKYRGKANRF
What is the function of this protein?
Proton-coupled antiporter flippase that catalyzes the translocation, from the inner to the outer leaflet of the cell membrane, of the lipid-linked disaccharide (anchor-LLD) that anchors lipoteichoic acids (LTA) to the cell membrane.
What are the official names of this protein?
Proton-coupled antiporter flippase LtaA, Lipoteichoic acid protein A.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LtaA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: STK11_MOUSE
Sequence: MDVADPEPLGLFSEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPCDCGPPLSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRSMTVVPYLEDLHGRAEEEEEEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLPKAVCVNGTEPQLSSKVKPEGRPGTANPARKVCSSNKIRRLSACKQQ
What is the function of this protein?
Has a role in spermiogenesis.
What are the official names of this protein?
Serine/threonine-protein kinase STK11, Liver kinase B1 homolog, LKB1, mLKB1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Membrane. Mitochondrion. Note=Translocates to mitochondrion during apoptosis (By similarity). A small fraction localizes at membranes. Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). PTEN promotes cytoplasmic localization (By similarity). SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta).
Protein: UBIA_SACD2
Sequence: MTATRKSTRPSKPLKATLVAYAKLMRLDRPIGIYLVLWPTLWSLWIAADGLPDWDVLVIFVLGVVLMRSAGCVINDFADRKIDGHVRRTANRPLVTGLITPKQAVLFFVALLVIAFILVLFTNPLTIKLSFGGALLAFCYPFMKRYTQLPQIVLGAAFAWSIPMAFAAQTNQLPEAIWVLYTAVVLWTVAYDTFYAMADREDDLKIGVKSTAILFGDQDRIITACLQLMALVAMAMAGERFGLGFSFKVSLLVAGGLFAYQQYLIRNREPNACFRAFLHNNWVGLVVFLGILVDKLITN
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CMU1_USTMA
Sequence: MKLSVSIFVLLAVSAFGGGSAAAVSGKSEAAEIEAGDRLDALRDQLQRYETPIIQTILARSALGGRAPSEQDEVRAALSRNAFEPSEVISEWLQTESGARFRSTRPLPPAVEFITPVVLSRDTVLDKPVVGKGIFPIGRRPQDPTNMDEFLDTSLLSLNQSSTVDLASAVSLDVSLLHLVSARVLLGYPIALAKFDWLHDNFCHILTNTTLSKSQKLANIIQQLTDHKQEVNVLSRVEQKSKSLSHLFRNDIPYPPHTQDRILRLFQAYLIPITTQIEAAAILDHANKCT
What is the function of this protein?
Secreted chorismate mutase that is one component of a cocktail of effectors shaping the host metabolome and acting as virulence factors.  The enzyme is taken up by plant cells, can spread to neighboring cells where it affects the biosynthesis of the plant immune signal salicylic acid by channelling chorismate into the phenylpropanoid pathway (PubMed:21976020, PubMed:30651637).  Interfers with the activity of host cytosolic chorismate mutase CM2 through heterodimerization (PubMed:21976020).
What are the official names of this protein?
Secreted chorismate mutase.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm, host cytosol. Note=Is translocated to host plant cells and spreads to neighboring tissue. The spreading is likely to occur through plasmodesmata.
Protein: TIG_COXB1
Sequence: MRGNFMSSIEKLGGLKQRLTITVSAEEVDKAYKSRLLKVARTAKIPKFRPGKASPAVVEKLYGKAILQEVGSELIQSSLREAVEEHQLRVAGAPDIKMDKILRGEPFKYVVNFEVYPEITLESLAGETIERTQVEITEEDLDKMLEALRKQYAEWKEVDRPAKADDRVIIDFEGTLDGKPFERGSAKDFQLELGSKRMIAGFEEGIEGMKPGESKALDITFPADYPSEDLAGKAAVFNITLQKVMAPELPVLDEQFAERLGIKEGGLEALRQKVRTNMEKEVHHHMENKLKMAVLDKLIERNPIEVPESLIEAEIDHLQQMTRQQVAMQTHKPDEAKKMELPRDPYREQATKRVKLGLLLAEVVKQHKIKADPEQLRARVEEVAASYQDPEKVISWYYSNKQMLSEIESVVLEDQAVAQLMSELEVEDQAIPYEEAVKQIQQ
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: MDC1_RAT
Sequence: MENTQVIDWDAEEEEETEISSGSLGYSVEPIGRLRFFSGTHGPERDFPLYLGKNVVGRSPDCSVALPFPSISKQHAVIEISAWNKAPILQDCGSLNGTQIVKPPRVLAPGVSHRLRDQELILFADFPCQYHRLNVPPPLVPRSLLTIEKTPRIRGRSQNSRVLLAEDSEEEGDFPSGRSVANGSRNTASPSATVVPESDEEGSSPGPSVPGPSSPFGLGSDTDESQGQQPGVEESSLADNSGAAGEPEQPEVNGVTTGTLAQPTKDKFKDTKMKEEAGSAGVPVGSVVEGSPTLGEDSDTEADEERQPSGSGDSDTDVEEERVPVKKNQVLLGVGIGGPGARGVAHLQDSPTGSDTDVEEDKTALAAPPERSHTAMVINSDTDEEERGEEEEVSAALTLARLKERGIALWSGEPGTEEVKSQPQVLVERSQSASGRDSDTDVEEGSSGGKREIVPDSPMDVDETLTVTQPESQPPCRPNDVDEDVDMSSPGSHLEGKKASSALVDKNRAQVEEEVPGPSVTLGEKHQVPLEGAQPPEEARETAVQEGSSSPVADIRMSQQPVAEDAGTECAAAVSEQKSALEVGAQSRSPAAPVEQVVVRTDTSGDPTLPQREGAQTPTGREREAHVGGTKHAKECCDEPEDLCLSATQCFVEGESQHPGAVQSLEDEPTQVFPCLPQEPGPSHLSLPTPGADTLDVPWEVLATQPFCLREQTETSEPIDTHEAHGSQPSLPGEPPGHQHPVPTSLDHTELLRIDDREMQTVEKAMGHLSCQMMPDGKASGDDPEPSDHRLFSPVPEASASPQSLLTSQSQKQSTPQPMFPTSSSELALPETLHTKPNVRPRRSSRMTPSPHSSAALKPYTTCPTNQPAASRPTSRPTRGRANRSSTRTPELIVPTGPELQPSTSTEQPGIPNLTSQVTEGRAHSTSVNMPEPVLTGPEAQPLTSAEQSVTSNLNPRAQPLTLEPVPQTSHQRRRRATGKQGSRTAPVGPKSYSTPAEPEPQSSASQSSGASEADSPHQKRPRRQVTQKTVVVKEEDPGEIQVKEEPQETAIPTPGKRKRDPAEGETQGNPTRSRRTKPNQEAAAPKVLFTGVVDSRGERAVLALGGSLASSVNEASHLVTDRIRRTVKFLCAVGKGIPILSLNWLYQSRKAGCFLPPDDYLVTDPEQEKNFSFSLRDSLSRARERRLLEDYEIHVTPGVQPPPPQMGEIISCCGGTVLPSMPHSYKLHRVVITCTEDLPRCAIASRLGLPLLSPEFLLTGVLKQEATPEAFVLSNLEM
What is the function of this protein?
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle.  May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX.  Also required for downstream events subsequent to the recruitment of these proteins.  These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis.  ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1 (By similarity).
What are the official names of this protein?
Mediator of DNA damage checkpoint protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires phosphorylation of H2AX. Colocalizes with APTX at sites of DNA double-strand breaks (By similarity).
Protein: POLS_EEEVF
Sequence: MFPYPTLNYPPMAPINPMAYRDPNPPRRRWRPFRPPLAAQIEDLRRSIANLTLKQRAPNPPAGPPAKRKKPAPKPKPAQAKKKRPPPPAKKQKRKPKPGKRQRMCMKLESDKTFPIMLNGQVNGYACVVGGRVFKPLHVEGRIDNEQLAAIKLKKASIYDLEYGDVPQCMKSDTLQYTSDKPPGFYNWHHGAVQYENNRFTVPRGVGGKGDSGRPILDNKGRVVAIVLGGVNEGSRTALSVVTWNQKGVTVKDTPEGSEPWSLATVMCVLANITFPCDQPPCMPCCYEKNPHETLTMLEQNYDSRAYDQLLDAAVKCNARRTRRDLDTHFTQYKLARPYIADCPNCGHSRCDSPIAIEEVRGDAHAGVIRIQTSAMFGLKTDGVDLAYMSFMNGKTQKSIKIDNLHVRTSAPCSLVSHHGYYILAQCPPGDTVTVGFHDGPNRHTCTVAHKVEFRPVGREKYRHPPEHGVELPCNRYTHKRADQGHYVEMHQPGLVADHSLLSIHSAKVKITVPSGAQVKYYCKCPDVREGITSSDHTTTCTDVKQCRAYLIDNKKWVYNSGRLPRGEGDTFKGKLHVPFVPVKAKCIATLAPEPLVEHKHRTLILHLHPDHPTLLTTRSLGSDANPTRQWIERPTTVNFTVTGEGLEYTWGNHPPKRVWAQESGEGNPHGWPHEVVVYYYNRYPLTTIIGLCTCVAIIMVSCVTSVWLLCRTRNLCITPYKLAPNAQVPILLALLCCIKPTRADDTLQVLNYLWNNNQNFFWMQTLIPLAALIVCMRMLRCLFCCGPAFLLVCGALGAAAYEHTAVMPNKVGIPYKALVERPGYAPVHLQIQLVNTRIIPSTNLEYITCKYKTKVPSPVVKCCGATQCTSKPHPDYQCQVFTGVYPFMWGGAYCFCDTENTQMSEAYVERSEECSIDHAKAYKVHTGTVQAMVNITYGSVSWRSADVYVNGETPAKIGDAKLIIGPLSSAWSPFDNKVVVYGHEVYNYDFPEYGTGKAGSFGDLQSRTSTSNDLYANTNLKLQRPQAGIVHTPFTQAPSGFERWKRDKGAPLNDVAPFGCSIALEPLRAENCAVGSIPISIDIPDAAFTRISETPTVSDLECKITECTYASDFGGIATVAYKSSKAGNCPIHSPSGVAVIKENDVTLAESGSFTFHFSTANIHPAFKLQVCTSAVTCKGDCKPPKDHIVDYPAQHTESFTSAISATAWSWLKVLVGGTSAFIVLGLIATAVVALVLFFHRH
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to target cell and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits.  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group.
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. Host nucleus. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: METK_FLAPJ
Sequence: MAYLFTSESVSEGHPDKVADQISDALIDNFLAFDAQSKVACETLVTTGQVILAGEVKSNTYLDVQNIAREVIRKIGYTKSEYMFEANSCGILSAIHEQSADINQGVDRASKEEQGAGDQGMMFGYATNETENYMPLALDLSHALLIELANLRRENNDIKYLRPDAKSQVTLEYSDDNKPQRIDAIVISTQHDDFDEEATMLAKIKTDLVSILIPRIKAKYPQYAHLFNDQITYHINPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAYATRHIAKNLVAAGICDEILVQVSYAIGVAKPTSINVVTYGTSKVNLTDGEISKKVEAIFDMRPYFIEQRLKLRNPIYSETAAYGHMGRTPETVTKTFSAPGGLTKTVEVELFTWEKLDFVDTVKTAFGI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_LEIXX
Sequence: MAKIADSIDSAQADSVENVESYSTETPESAAPAAPRPVLSVPGAAVGRRKEAIARVRLVPGAGAVTVNGRAFADYFPNKLHQQLITDPFKVLDLVGSYDVIARITGGGPSGQAGALRLAIARALNEIDRENNRPTLKKAGFLTRDARVTERKKAGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: HLDE_CITK8
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVDTIEERPGGAANVAMNIASLGANSRLVGLTGIDDAARALSKTLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPLPLHERINQALGSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVAGKCKSEEEIVERGMKLIADFEFSALLVTRSEQGMTLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACYFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEAELKQAVASARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGETRPVNPLEQRMIVLGALESVDWVVSFDEDTPQRLIAGVLPDLLVKGGDYKPEEIAGSEEVWANGGEVLVLNFEDGCSTTNIIKKIQKDSDK
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: CDK20_MACMU
Sequence: MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMGDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRSSLSCRTTTRSPLRSRCPCPWRRCCLTSLPRHWICWVNSFSTLLTSASQLPRLSSISTSSQLPCLPIHLSCRFLSV
What is the function of this protein?
Required for high-level Shh responses in the developing neural tube.  Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling.  Involved in cell growth.  Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 20, CDK-activating kinase p42, CAK-kinase p42, Cell cycle-related kinase, Cell division protein kinase 20, Cyclin-dependent protein kinase H.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium.
Protein: PAND_THEAB
Sequence: MQEIMLKSKIHMAKVTDKSINYMGSIGIDTELLEKAGMKPYELVLVADVNNGQRFVTYIIPEEKGSKKIVINGAAARLVEQGDRVIIMAFGMYDSNEYKGPKVIIMNEKNEIVEIKQEGV
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR14_CHLAT
Sequence: MAKKSMIEREKKRQKLVAKYAELRKEIKEQMRLASSFEEKLNLHRKLQRLPRNSSSTRLHNRCAISGRPKAYYRDFGLSRHVFREMAHNCLLPGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NUOI_YERE8
Sequence: MTLKELVVGFGTQVRSLWMIGLHAFHKRETQMYPEEPVYLPPRYRGRIVLTRDPDGEERCVACNLCAVACPVGCISLQKAEHKDGRWYPEFFRINFSRCIFCGLCEEACPTTAIQLTPDFEMGEFKRQDLVYEKEDLLISGPGKYPEYNFYRMSGMAIDGKLKGEAENEAKPIDVKGLMP
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.