PharMolix/UniProtQA huggingface dataset:
Protein: RT78_ECOLX
Sequence: MSVIRRLAAVLRQSDSGISAFLVTAPRKYKVYKIPKRTTGFRVIAQPAKGLKDIQRAFVQLYNFPVHDASMAYMKGKGIRDNAAAHAGNQYLLKADLEDFFNSITPAIFWRCIEMSSALTPQFEPQDKFFIEKILFWQPIKHRKTKLILSVGAPSSPVISNFCMYEFDNRIHAACNKLEITYTRYADDLTFSCNIPNVLKAVPSTIEALLKDLFGSELRLNHSKTVFSSKAHNRHVTGVTINNEETLSLGRDRKRFIKHLINQYKYGLLDNEDKAYLTGLLAFASHIEPGFITRMNEKYSLELMGRLRGQR
What is the function of this protein?
Reverse transcriptase (RT) component of antiviral defense system retron Ec78, composed of a non-coding RNA (ncRNA), this reverse transcriptase (RT), a probable ATPase and a putative HNH endonuclease.  Expression of retron Ec78 confers protection against bacteriophage T5.  At multiplicity of infection (MOI) of 0. 02 cultures slow growth when infected with T5 but do not collapse, at MOI 2 cultures enter growth stasis (PubMed:33157039).  Responsible for synthesis of msDNA-Ec78 (a linear ssDNA with a 5'-terminal phosphate residue).  Unlike most known msDNAs the mature product does not have an RNA component.  The retron transcript serves as primer and template for the reaction, and codes for the RT.  Not mutagenic when cloned in E. coli (PubMed:9281493).  It is thought to be synthesized as a branched RNA with a 2',5'-phosphodiester linkage to ssDNA; the linkage is cleaved endonucleolytically by ExoVII (xseA-xseB) leaving the observed mature 5'-ssDNA terminus (Probable) (PubMed:26626352).  Overexpression of the ncRNA and RT, which leads to increased levels of msDNA, is not mutagenic in vivo.  As the stem in the msDNA does not have a mismatch it probably does not bind or sequester MutS and/or MutL (PubMed:7885227).
What are the official names of this protein?
Retron Ec78 reverse transcriptase, RT.
What is the protein family that this protein belongs to?
Belongs to the bacterial reverse transcriptase family.
Protein: RSIW_BACLD
Sequence: MSCPEHIVQLMHKYLDGDILPEDETRLKEHLQSCEGCKKHLHEMEKSIALVQSTSHLTAPANFTANVLANLPKEKRTASINRWLKAHPFLVAAALFAILMGGSFFSSWKNDHDFSVSSQPNLVVKNNTVIVPEGEVVKGDVTVKNGKLIIEGKVDGDVTIVNGEKYTASAGQVTGQIHEINEVFDWIWYKIKSTGKSVFGVKESKE
What is the function of this protein?
Is the anti-sigma factor for SigW.  The presence of RsiW leads to the inactivation of SigW, and its proteolytic destruction to sigma-W activation (By similarity).
What are the official names of this protein?
Anti-sigma-W factor RsiW.
What is the protein family that this protein belongs to?
Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Note=Site-2 clipped RsiW is released from the membrane to the cytoplasm.
Protein: SOL1_SCHPO
Sequence: MNNQGFVPASDYPTAVSYPTQGQSYNTQEEQPAYPQRFSTSQGMYAAEYGNANMMNTSENEPNNLAHSQPFRQSPSTQRNLPNQSFDFASNGAWNGSGSVKYSSPMMPSSRIPFQQEKEAAMQQQQQQQQQQQLYQRQMQSREALLSQQIPPNQIGINAHPAVRQTPQPAPSPNTPSGNANQLTPAYAASFDKFMVSLISFMEKRGTPIKSYPQINNTPINLMMLYALVMRAGGSRQVSAHNFWPKISASLGFPSPDAISLLIQYYNSYLLPYEEAWLAAQQQQKSLQQAKANHSANVQSRPKNYPQKPVQTTPEAVHANGSMHGSLHSKSPSPAFTANRFSPAAPTTVSSERNAPPYPSAPTRPTPPTVQTSSSAAPVDSAEPVAYQPIKKPIDPMLGYPLNVAATYRLDESLLRLQMPSIVDLGTVNIQALCMSLQSTLEKEITYAMNVLLILTNDQKWMFPLSECQDVVDALIDVATQCLDNLLSVLPNEDLMEIADKRPSYRQLLYNCCVEISQFSREDFSNSLSENKTKDSINAIDVHNSEQNLLAVFVIFRNLSHFEANQNVLVQNPDFFPLLIRVVKSLNFHATSLLRSSRNTLDLHKDVLIVLCQLSQNFILPNVDVARHVLLFILSFSPFNRKKSKTILNDTLPTSIPSYTPATHPYAGPAINAYAKLLAKDANNKTNFQAIFDNNPKFLDSLFLLLASVVPKFNRHCLKICERRLPLLQQSFFCLAATVSYVKQSEQAANWCNIGEGFFVSMLRLLILLSGHPSLNPPSRVASQYPTTNPFRYVIQSGISTVRRLLSLVEAGNISLSSFPKSETLLAVLLAPTTETSFLKEISNLLDRTGDSDASLENTDDKSGI
What is the function of this protein?
Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes.  It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
What are the official names of this protein?
SWI/SNF chromatin-remodeling complex subunit sol1, SWI/SNF complex subunit sol1, Switch one-like protein, Transcription regulatory protein sol1.
What is the protein family that this protein belongs to?
Belongs to the SWI1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1029_KLEP7
Sequence: MYPVDLHMHTVASTHAYSTLHDYIAEAKRKGIKLFAITDHGPDMADAPHYWHFVNMRIWPRLVDGVGILRGIESNIKNIEGEIDCSGPMLTSLDLIIAGFHEPVFPPQDRDTHTQAMIAAMASGKVHMISHPGNPKFPVDIPAIAEAAARYQVALEINNSSFVSSRMGSEDNCRAIAAAVRDAGGWVALGSDSHTAFTLGEFTECRKILDAVDFPEERILNVSPRRLLNFLESRGMPAIPEFADL
What are the official names of this protein?
Probable phosphatase KPN78578_10290.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: Y6401_NOSP7
Sequence: MTYCLRIADLPTNERPRERLMTHGAKILATAELIAILLGTGQGPGKLSAVGLGQFILSELGKHQRDPLAVLREVSPAELMLISGVGPAKATSILAAIELGKRAFQSRPNDGTLIDSPLAAAATLSQDLMWQTQERFAVVLLDVKNRLLGTQVITIGTATETLASPRDIFREVIRQGATRAIVAHNHPSGNLEPSQEDIELTRQLLAGAQLLGIPVLDHLILGNGNHQSLREITTLWDEHPQGD
What are the official names of this protein?
UPF0758 protein Npun_R6401.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: MIAB_MYCTO
Sequence: MSSASPLARCCDEATPSAGPRAAQPPYHGPVTSMVAHDAAAGVTGEGAGPPVRRAPARTYQVRTYGCQMNVHDSERLAGLLEAAGYRRATDGSEADVVVFNTCAVRENADNRLYGNLSHLAPRKRANPDMQIAVGGCLAQKDRDAVLRRAPWVDVVFGTHNIGSLPTLLERARHNKVAQVEIAEALQQFPSSLPSSRESAYAAWVSISVGCNNSCTFCIVPSLRGREVDRSPADILAEVRSLVNDGVLEVTLLGQNVNAYGVSFADPALPRNRGAFAELLRACGDIDGLERVRFTSPHPAEFTDDVIEAMAQTRNVCPALHMPLQSGSDRILRAMRRSYRAERYLGIIERVRAAIPHAAITTDLIVGFPGETEEDFAATLDVVRRARFAAAFTFQYSKRPGTPAAQLDGQLPKAVVQERYERLIALQEQISLEANRALVGQAVEVLVATGEGRKDTVTARMSGRARDGRLVHFTAGQPRVRPGDVITTKVTEAAPHHLIADAGVLTHRRTRAGDAHTAGQPGRAVGLGMPGVGLPVSAAKPGGCR
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE3_HALH5
Sequence: MRLSPVEKEKLFLFMAGELAKQRMDRGLKLNYPEAVAILSCYVLEGAREGKSVSELMKDGKHVLSTEDVMEGVPEMLEEIQVEATFPDGVKLVTIHEPIQ
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
Protein: CRBL_VESAN
Sequence: FLPMIAKLLGGLL
What is the function of this protein?
Mast cell degranulating peptide.  Induces the chemotaxis of neutrophils.
What are the official names of this protein?
Vespid chemotactic peptide A, VESCP-A.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Crabrolin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL17_SINMW
Sequence: MRHGKAGRKLNRTASHRKAMFANMAASLIEHEQIVTTLPKAKEIRPIVEKLVTLGKRGDLHARRQAVSQIRDVAVVAKLFDAIASRYATRNGGYLRIMKAGFRQGDNAPLAVIEFVDRDADAKGSKDRARVAAEAEAAEAA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: HXK2_SCHPO
Sequence: MEANFQQAVKKLVNDFEYPTESLREAVKEFDELRQKGLQKNGEVLAMAPAFISTLPTGAETGDFLALDFGGTNLRVCWIQLLGDGKYEMKHSKSVLPRECVRNESVKPIIDFMSDHVELFIKEHFPSKFGCPEEEYLPMGFTFSYPANQVSITESYLLRWTKGLNIPEAINKDFAQFLTEGFKARNLPIRIEAVINDTVGTLVTRAYTSKESDTFMGIIFGTGTNGAYVEQMNQIPKLAGKCTGDHMLINMEWGATDFSCLHSTRYDLLLDHDTPNAGRQIFEKRVGGMYLGELFRRALFHLIKVYNFNEGIFPPSITDAWSLETSVLSRMMVERSAENVRNVLSTFKFRFRSDEEALYLWDAAHAIGRRAARMSAVPIASLYLSTGRAGKKSDVGVDGSLVEHYPHFVDMLREALRELIGDNEKLISIGIAKDGSGIGAALCALQAVKEKKGLA
What is the function of this protein?
Catalyzes the phosphorylation of hexose (six-carbon sugars) to hexose 6-phosphate (PubMed:8549830, PubMed:9790975).  Phosphorylates D-glucose, D-fructose and D-mannose (PubMed:8549830, PubMed:9790975).  Compared to hxk1, has a much higher affinity for D-glucose (PubMed:8549830, PubMed:9790975).  Constitutes the initial enzyme of glycolysis by catalyzing the phosphorylation of glucose to D-glucose 6-phosphate (Probable).
What are the official names of this protein?
Hexokinase-2.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
Protein: LEUD_YERPE
Sequence: MAKFIQHIGLVAPLDAANVDTDAIIPKQFLQKVTRTGFGQHLFNDWRFLDDAGKVPNPDFVLNLPRYQGATILLARENFGCGSSREHAPWALTDFGFKVVIAPSFADIFYGNAFNNQLLPVTLSEADIDTLFQLVKENEGIEFVVDLEQQTVNAGGKSYAFEIDPFRRHCMINGLDSIGLTLQHEHNISAYEKQQPEFLR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: YBHG_SALCH
Sequence: MKKPVVIGLAIAAIVAVIAGGTWWYQSRQDDGLTLYGNVDIRTVNISFRVGGRLASLNVDEGDTIKAGQVLGELDHAPYENALMQAKAGVSVAQAQYDLMLAGYRDEEIAQAAAAVRQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLSQYRTGNREQDIAQAKASLEQAKAQLAQAQLDLQDTTLIAPANGTLLTRAVEPGSMLNAGSTVLTLSLTRPVWVRAYVDERNLSQTQPGRDILLYTDGRPDKPYHGKIGFVSPTAEFTPKTVETPDLRTDLVYRLRIIVTDADDALRQGMPVTVKFNDEARHE
What are the official names of this protein?
UPF0194 membrane protein YbhG.
What is the protein family that this protein belongs to?
Belongs to the UPF0194 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MSBA_SALPA
Sequence: MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGIALILNAASDTFMLSLLKPLLDDGFGKTDRSVLLWMPLVVIGLMILRGITSYISSYCISWVSGKVVMTMRRRLFGHMMGMPVAFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILVVLAPIVSIAIRVVSKRFRSISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNKMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFAILDSEQEKDEGKRVIDRATGDLEFRNVTFTYPGREVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGHILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEEYSREQIEEAARMAYAMDFINKMDNGLDTIIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLMIAHRLSTIEQADEIVVVEDGIIVERGTHSELLAQHGVYAQLHKMQFGQ
What is the function of this protein?
Involved in lipopolysaccharide (LPS) biosynthesis.  Translocates lipid A-core from the inner to the outer leaflet of the inner membrane.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
ATP-dependent lipid A-core flippase, Lipid A export ATP-binding/permease protein MsbA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYB_MYORT
Sequence: MTIIRKKHPLIKIINHAFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLTGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLTLILSILILALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFAIIVIFMPMAGMIENNILDLD
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NLE_DROME
Sequence: MLAKKQKMQETDTEQEATPHTIQARLVSDTGEEAGPPIDLPAGITTQQLGLICNALLKNEEATPYLFFVGEDEIKKSLEDTLDLASVDTENVIDIVYQPQAVFKVRPVTRCTSSMPGHAEAVVSLNFSPDGAHLASGSGDTTVRLWDLNTETPHFTCTGHKQWVLCVSWAPDGKRLASGCKAGSIIIWDPETGQQKGRPLSGHKKHINCLAWEPYHRDPECRKLASASGDGDCRIWDVKLGQCLMNIAGHTNAVTAVRWGGAGLIYTSSKDRTVKMWRAADGILCRTFSGHAHWVNNIALSTDYVLRTGPFHPVKDRSKSHLSLSTEELQESALKRYQAVCPDEVESLVSCSDDNTLYLWRNNQNKCVERMTGHQNVVNDVKYSPDVKLIASASFDKSVRLWRASDGQYMATFRGHVQAVYTVAWSADSRLIVSGSKDSTLKVWSVQTKKLAQELPGHADEVFGVDWAPDGSRVASGGKDKVIKLWAY
What is the function of this protein?
Plays a role in regulating Notch activity.
What are the official names of this protein?
Protein Notchless.
What is the protein family that this protein belongs to?
Belongs to the NLE1/RSA4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: SYS_HELAN
Sequence: MLDINLFREEKGGNPEIVRESQRRRGASVEIVDEIIKLDKEWRQRQFELEQLRKDFNRINKEVAKLRISGGDASSLIKNTEENKDSTAKKQAEVQEARTALYSKLETVGNLVHDSVPVSNDEADNAVVRTWGERREETNLKNHVELVELLGIADLKKGANVAGGRGYYLKGDGVRLNQALINFGLDFLEKRKYTALQTPFFMRKDIMGKCAQLAQFDEELYKVTGEGDDKYLIATAEQPLCAYHIDDWIHPNELPLRYAGYSSCFRKEAGSHGRDTLGIFRVHQFEKVEQFCLTKPSGNDSWEMHEEMIKNSEEFYQMLKLPYQVVSIVSGALNDAAAKKYDLEAWFPASKTYRELVSCSNCTDYQSRKLEIRCGQKKGNEQAKQYCHLLNSTLTATERTLCCILENYQTEKGVAIPEVLQPFMGGKTFLDFLKKIKK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
Protein: PANC_ECOBW
Sequence: MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADVVVVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYPNGTETHTYVDVPGLSTMLEGASRPGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRKMVADMGFDIEIVGVPIMRAKDGLALSSRNGYLTAEQRKIAPGLYKVLSSIADKLQAGERDLDEIITIAGQELNEKGFRADDIQIRDADTLLEVSETSKRAVILVAAWLGDARLIDNKMVELA
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANXA3_BOVIN
Sequence: MASIWVGKRGTIRDYAGFNPSVDAEAIRKAIRGIGTDEKTLISILTERTNAQRLLIAKEYQALCGKELKDDLKGDLSGHFKHLMVALVTPPAVFDAKQLKKSMKGMGTNEDALIEILTTRTSKQMQEIGHAYYTAYKKSLGDEISSETSGDFRKALLILANGRRDESLKVDEQLARKDAQILYNAGEKRWGTDEDAFTNILCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAIVRCARNTPAFLAERLYRALKGAGTDEFTLNRIMVSRSEIDLLDIRAEFKKLSGYSLYSAIKSDTSGDYEITLLKICGGDD
What is the function of this protein?
Inhibitor of phospholipase A2, also possesses anti-coagulant properties.  Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate (By similarity).
What are the official names of this protein?
Annexin A3, Annexin III, Annexin-3.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
Protein: SSRP_FLAPJ
Sequence: MLKTVNILNKRAKFEYEIIDRYTAGMVLTGTEIKSIRLGKANIAESFCEFQGDELFVINSHIEEYLFGHQYNHKPKSERKLLLNKRELKGLLKDVQNKGLTIIPLRLFTNEKGMAKLDIALCKGKKTFDKRETIKDRDNKRDLDRIKKEF
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: DNAJ_BLOPB
Sequence: MAKSDYYEILGISKNADEREIKKSYKRLAMKFHPDRNPGNTTAETKFKEIKEAYEVLSNSEKRAAYDQYGHAAFESGSMGATSNSGGADFSDIFGDVFGDIFGGNRRSRAGRGSDLRYNIELSLEDAVRGIIKEICIPTLSTCEKCRGTGARSNAAIITCMTCHGQGQVQIRQGFFSVQQSCPTCHGHGKIIKEACNKCHGNGRVERSKTLSVKIPSGVNTGDRIRLSGEGESGKNGAPSGDLYVQIQIRKHPIFDREEKNLYCEVPISFSMAALGGEIEVPTLDGRVKLKIPPETQTGKLFRMRGKGVKSVRSGGNGDLLCRVVVETPVKLNDIQKRLLQDLSDSFEGPHGNRNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPT4_YEAST
Sequence: MSSERACMLCGIVQTTNEFNRDGCPNCQGIFEEAGVSTMECTSPSFEGLVGMCKPTKSWVAKWLSVDHSIAGMYAIKVDGRLPAEVVELLPHYKPRDGSQVE
What is the function of this protein?
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing.  The complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.  Structural and functional component of the centromeric and heterochromatic loci linking chromatin structure with kinetochore function and gene silencing.
What are the official names of this protein?
Transcription elongation factor SPT4, Chromatin elongation factor SPT4.
What is the protein family that this protein belongs to?
Belongs to the SPT4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome. Note=Centromere and heterochromatin (PubMed:15057281). Associates with the coding region of HTA1 (PubMed:19683497).
Protein: RL25_SACD2
Sequence: MSNEDFILNAEARDVSGKGASRRLRREAGLVPAIVYGGRKNPQNVTITLRELTKHLENEAFYSHIITLNIGDSSEQVILKDLQRHPATNFAMHADFLRVSKTKKFNTKVPLHFINEATSKGVKEQGGKVQHSMTELEIACLPADLPEFIEVDLANVELGGIVHISDIVLPKGVESIALQQGEDHDLPVASIFKPKGVAGDEDEEAEGDAE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: SMS2_LOPAM
Sequence: MQCIRCPAILALLALVLCGPSVSSQLDREQSDNQDLDLELRQHWLLERARSAGLLSQEWSKRAVEELLAQMSLPEADVQREAEDASMATGGRMNLERSVDSTNNLPPRERKAGCKNFYWKGFTSC
What is the function of this protein?
Somatostatin inhibits the release of somatotropin.
What are the official names of this protein?
Somatostatin-2, Somatostatin II.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RHLB_SHEB2
Sequence: MSETHLSTQRFADLPLHPEVKQALAENGFEFCTPIQALSLPVLLQSKDIAGQAQTGTGKTMAFLVATFNHLLSTPVPEGRLINQPRAIIMAPTRELAIQIAKDAILLAKHTHLKVGIVYGGESYDVQRKVLDQGVDILIGTTGRIIDYVRQGIIGLNSIQAVVLDEADRMFDLGFIKDIRFLFRRMPEANQRLNMLFSATLSMKVQELAYDHMNEPVKVEIAPEEKTSKNIKEEIFYPSQEEKMRLLLTLIEEDWPEKAIVFSNTKHSCETLWSWLEGDGHRVGLLTGDVPQKKRIRILEQFTSGQLDILVATDVAARGLHISDVSHVYNYDLPDDCEDYVHRIGRTGRAGNKGMSISFACEEYALNLPAIESYINHSIPVSNYDSEALLADIPTPAKIHRKHPSGTRNLRDRSGTSRPGAQRSGARPPRHDRTRRHS
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S115A_MOUSE
Sequence: MPDTPVEDSLFQIIHCFHHYAAREGDKETLSLEELKALLLDSVPRFMDTLGRRQPYYITELFRAADKNKDNQICFDEFLYILGKLVKDYHLQFHRQLCAHYCTEHSLY
What are the official names of this protein?
Protein S100-A15A, Protein S100-A7A, S100 calcium-binding protein A15A, S100 calcium-binding protein A7A.
What is the protein family that this protein belongs to?
Belongs to the S-100 family.
Protein: HMGCL_BOVIN
Sequence: MATVKKVLPRRLVGLATLRAVSTSSVGTFPKQVKIVEVGPRDGLQNEKNIVPTPVKIKLIDMLSEAGLPVVEATSFVSPKWVPQMADHAEVLKGIQKFPGVNYPVLTPNFKGFQAAVAAGAKEVAIFGAASELFTKKNINCSIDESLQRFDEILKAARAAGISVRGYVSCVLGCPYEGKISPAKVAEVTKKLYSMGCYEISLGDTIGVGTPGAMKDMLSAVLQEVPVTALAVHCHDTYGQALANTLTALQMGVSVMDSSVAGLGGCPYAQGASGNLATEDLVYMLAGLGIHTGVNLQKLLEAGAFICQALNRRTNSKVAQATCKL
What is the function of this protein?
Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis.  Terminal step in leucine catabolism.  Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
What are the official names of this protein?
Hydroxymethylglutaryl-CoA lyase, mitochondrial, HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA lyase family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Peroxisome. Note=Unprocessed form is peroxisomal.
Protein: GLYA_LACLA
Sequence: MIFDKEDFESFDPELWAAIHAEEIRQQQNIELIASENIVSKAVMAAQGSVLTNKYAEGYPGKRYYGGTEAVDVVENLAIERAKELFGAKFANVQPHSGSQANAAAYMALIQPGDTVLGMDLNAGGHLTHGASVNFSGKTYHFVPYGVNSETELLDYDEILKIAKQVQPKLIVAGASAYSRLIDFAKFREIADSVGAKLMVDMAHIAGLVATGAHPNPLPYADVVTTTTHKTLRGPRGGMILTNDEALAKKINSAIFPGTQGGPLEHVIAAKAVAFKEALDPEFTTYIEQVIKNTQAMAEEFAKVEGLRLIAGGSDNHLLNLKVLDLGINGKEAQDLLDSVHITLNKEAIPDETLSPFKTSGVRIGAAAITSRGFKEVEAKKVAQLVSEALVNHDNQEKLAEVRKAALELTRQFPL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.