PharMolix/UniProtQA huggingface dataset:
Protein: PRC3B_XENLA
Sequence: RRRRSQGSEVNLTGQGQPCHSCGERCPGFLAHKWRKICQHCQCPWEEHGHTASNQDLERSLCRLVSGSQRDSLCDSSSDSSVEKYAWVPSGLNPVQVHHFFKCFPEKKIPYINSPGEKYRLKQLLHQLPPHDSEARYCCSLQGEEEEELLLLFSQKRRLENLGRGCVRPISGTMSGTVCQQCGHQINVGEVAVFASRAGLGFCWHPQCFTCAQCLELLCDLIYFYQDGKVYCGRHHAELKRPRCLACDEVIFSLECTQAEGFHWHTRHFCCFECECPLGGQRYIMKDQRPFCCSCYERLYAQYCDSCGECIGIDEGQLTYGGQHWHASESCFCCGRCGECLLGRPFLPRHGQIYCSRSCSMLHTKSERPFSPSQMDLSFQKETKDVGTSTNHELEGDSITNCTLAGSRTSLSVIDQTPTQAAPARSLHSSLRGAPKGFSRECPNRRSLPDLSSHTRTPTRVTFQLPSHSEIKESISFSRPSFTSSSSSDEEEGYFLGEPIPLPPFLRSPGYTAPPTHVPTSTRKQKKKKDKSCFLS
What is the function of this protein?
Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity).  PCP is maintained by two molecular modules, the global and the core modules (PubMed:23140624).  Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo) (PubMed:23140624).  The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells (PubMed:23140624).  Distinct proximal (Vang, Pk and Fmi) and distal (Fz, Dsh, Dgo and Fmi) complexes segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (PubMed:23140624).  Directional information to orient polarization with respect to the tissue axes is provided by the global module which involves Wnt proteins (PubMed:23140624).  Involved in the organization of the basal body (By similarity).  Involved in cilia growth and positioning (By similarity).  Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (By similarity).
What are the official names of this protein?
Prickle planar cell polarity protein 3-B, LIM domain only protein 6-B, LMO6-B, Prickle-like protein 3-B, Pk3-B.
What is the protein family that this protein belongs to?
Belongs to the prickle / espinas / testin family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion. Note=Recruited by vangl2 to anterior cell borders. This polarity is controlled by wnt proteins (By similarity). Wtip is involved in the recruitment of prickle3 to the basal body (By similarity).
Protein: FETP_AERS4
Sequence: MSRTVFCQRLKKEGPGLDFQLYPGELGKRIFDNISKEAWTEWQKKQVMLINEKKLNMMNLEHRQLLEKEMVSYLFEAGEVAIDGYTPPSQ
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: NUOI_FRATH
Sequence: MRNITNFLKTFLLWELLKGLKVTGKHFFTRKVTVQYPDEKTPISNRFRGLHALRRYENGEERCIACKLCEVVCPALAITINSTEREDGTRRTSSYEMDLFKCIFCGYCEESCPVDSIVETNILEYHFEERGENIMTKAKLLAIGDKYEAQIAADRLQDKDFR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EMID1_MOUSE
Sequence: MGGPRAWTLLCLGLLLPGGGAAWSVPGARFSGRRNWCSYVVTRTVSCHVQNGTYLQRVLQNCPWPMGCPGNSYRTVVRPLYKVTYKTVTAREWRCCPGHSGVTCEEGSPGLLEPTWTDSGMRRMAVRPTALSGCLNCSKVSELTERLKALEAKVAVLSVTEQTVPSVPATPEDSALLWGSPAARGSPGDGSLQDRLDSWGLPGPTGPKGGTDSQSPVRIRGPPGPQGPPGRPGQTGAAGTPGKMGPPGPPGPPGPPGPPAPVGPPYGQVSLHGDPLLSNTFTEMGSHWPQGPTGPPGPPGPPGPMGPPGLPGPMGAPGSPGHMGIPGPSGPKGTSGHPGEKGERGLPGEPGPQGLMGVPGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLILETMIGLYEPDLGSGAGPDGTGTPSLLRGKRGGHPTNYPIITPRRRSERS
What are the official names of this protein?
EMI domain-containing protein 1, Emilin and multimerin domain-containing protein 1, Emu1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: GLMM_METTH
Sequence: MKEKKPRLFGTSGIRGRFGEKVTLELTAEHRKALATHLGGDGEVVVGYDTRTSSQLLENALIAGIVECGCDVTRLGMVPTPLVGYAASRLGAAAGVMITASHNPAPYNGIKLWNPDGMAYRPSQERVIESIIHSRDFKRKAWDELGSITTVDMRDDYVRAVLETVEIKKPLKVVIDSGCGAASHLSPLIFRKAGCRVITLNSQPDGFFPGRDPEPVPENLSELMETVRSTGADLGIAHDGDADRMVAIDDQGRFASFDKLLALMAREIGGKIITTVDASLCVDECLGDRGEVIRTRVGDVHVANTIAEEGARFGGEPSGTWLHPDFCMCPDGILSALRVAELVSARGPLSELLEEVPSYPNIRDKVPCPDEKKDIIMERVAAELSDQFSETSDINTIDGVRISLDDGSWVLVRPSGTEPYIRITLEGKTEEKARYIHERTRGYLENVIG
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Probable phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: ACP_HELAH
Sequence: MALFEDIQAVITEQLNVDAAQVTLEAEFVKDLGADSLDVVELIMALEEKFGIEIPDEQAEKIVNVGDVVKYIEDNKLA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSRB_ECO5E
Sequence: MKVNDRVTVKTDGGPRRPGVVLAVEEFSEGTMYLVSLEDYPLGIWFFNEAGHQDGIFVEKAE
What are the official names of this protein?
Protein DsrB.
What is the protein family that this protein belongs to?
Belongs to the DsrB family.
Protein: SYT_CORGL
Sequence: MSARRSAIFVNTTDTAVANLVVFEVPAGTAIGAAMRELDLPNKGPEAIVCAKDAEGQLKDLSHVPETTATFTAVPANTDDGRAVIRHSCAHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDAAEPFTPEDLKTIEKRMKKIIKTGQKFERRVYESAEAAAEELKNEPYKLELIQDKGNVDPNSDEATEVGAGELTAYDNVNPRTSEVEWSDLCRGPHIPTTRYIPAFALTRSSAAYWRGDQDNAGLQRIYGTAWEDKESLDAYQTMLAEAEKRDHRRLGTELDLFSFPDDLGSGLPVFHPNGGIVRNEMEDHSRRRHIAAGYSFVNTPHITKQDLFERSGHLGFYKDGMFPPMQVDAEFDEDGNVTKPGQEYYLKPMNCPMHNLIFDSRGRSYRELPLRLFEFGNVYRYEKSGVIHGLTRARGFTQDDAHIYCTEDQLEAELTSVLDFILSLLRDYGLDDFYLELSTRDPKKSVGSDEIWERSTEILNRVATNSGLELVPDPEGAAFYGPKISVQARDAIGRTWQMSTVQLDFNMPERFNLEYTSSDGSKQQPIMIHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVMGIPVADDCIPHLETITAQLREKGIRADVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEANAVSFRFLDGTQVNGVPVDEAIAVISSWIGDRINDQPSEDSIAARR
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBR_ARATH
Sequence: MASDAVKYMPIHGGGTTATTAADIKSFFSALKPKKTSTFAYAFVITFVSFTLFFAFSPSPNSSSPWFSNIFTSSSTTTTSDNTSGSQFSSIFSYILPNVTSTKPTNRSSDATDSLSVNATSPPLNSNSKNGTLQTPAPETHTPVAKNTTFESPIVNGTNPDAKNNTSSHPLLSDKSSTTGSNNQSRTTADTETVNRNQTTSPAPSKAPVSVDLKTNSSSNSSTASSTPKKQTKTVDLVSSVKQEIEKWSESLKNCEFFDGEWIKDDSYPLYKPGSCNLIDEQFNCITNGRPDKDFQKLKWKPKKCSLPRLNGAILLEMLRGRRLVFVGDSLNRNMWESLVCILKGSVKDETKVYEARGRHHFRGEAEYSFVFQDYNCTVEFFVSPFLVQEWEIVDKKGTKKETLRLDLVGKSSEQYKGADVIVFNTGHWWTHEKTSKGEDYYQEGSNVYHELAVLEAFRKALTTWGRWVEKNVNPAKSLVFFRGYSASHFSGGQWNSGGACDSETEPIKNDTYLTPYPSKMKVLEKVLRGMKTPVTYLNITRLTDYRKDGHPSVYRKQSLSEKEKKSPLLYQDCSHWCLPGVPDSWNEILYAELIVKLNQLSQTQRKT
What is the function of this protein?
Required during cellulose deposition (PubMed:20388664).  May act as a bridging protein that binds pectin and other cell wall polysaccharides.  Probably involved in maintaining esterification of pectins (Probable).  May be involved in the specific O-acetylation of cell wall polymers (By similarity).
What are the official names of this protein?
Protein trichome birefringence.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: NA122_ANEVI
Sequence: MMNRLLVFLMLGAAFMLVVSAIDQDANEDINKRGVPCLCDSDGPSVRGNTLSGIIWLAGCPSGWHNCKKHGPTIGWCCKQ
What is the function of this protein?
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation during signal transduction (By similarity).  Has a strong effect on crustaceans and insects and a weaker effect on mammals (By similarity).  It strongly inhibits D. melanogaster sodium channel (DmNav1) (By similarity).  It strongly affects the heart sodium channels (Nav1. 5/SCN5A) and weakly inhibits the brain sodium channel Nav1. 2/SCN2A (By similarity).  In vivo, when released into the medium, this recombinant toxin induces impaired swimming, paralysis and death of the crustacean A. nauplii within several hours (PubMed:22048953).  Its effect on zebrafish (D. rerio) larvae is much faster, since it induces paralysis or strong convulsion and impaired swimming, within 10 minutes (PubMed:22048953).
What are the official names of this protein?
Delta-actitoxin-Avd1c 2, Delta-AITX-Avd1c 2, Anemonia viridis toxin 2, Av2, Avt 2, Toxin Av2-2.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Note=In nematocyst, is associated with the tubule prior to discharge.
Protein: PGA14_CANAL
Sequence: MKFTTVATVFAISSLAAAKGGEKDHGKASTVTKYVTETTHRYGRFDKTSRSKKPKETGTHRYGKFNKTPRPVTTTVLVKESDLPKKRDAVVARDSKNASSNSTTSSGNNGVATGVSLGLAGVLAVGAALVI
What is the function of this protein?
Hydrophilin which is essential to overcome the simple stress of the desiccation-rehydration process.
What are the official names of this protein?
Hydrophilin PGA14, Predicted GPI-anchored protein 14.
What is the protein family that this protein belongs to?
Belongs to the PGA14 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Protein: DCDB_KOCRD
Sequence: MLISDRDIRRHLDSGRVRLEPSDPAMVQPASVDVRLDRWFRLFDNHKYAHIDPEQEQPELTRLVEVAPDEPFVLHPGEFVLGATYEKVTLPDDIAARLEGKSSLGRLGLLTHSTAGFIDPGFSGHVTLELSNMATLPIKLWPGSKVGQLCFFQLSSPTEHPYGSGAYGNRYQGQRGPTASRSHLNFHRTVIE
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: LCRR_YEREN
Sequence: MMEDPLIPWLTEHGLVCHPHTLSGTPISLGSAFQLAGLKLAWRVEIEQRRVWIVLIQRVEQRRGLKNPFAALYMLANAARAVLGPDYYLYGNVDVLAGSSLSTQRLAHFYRRWTGAKELSTGWFSLKVSQVITLSNMKKRQNNGFA
What is the function of this protein?
Involved in the down-regulation of lcrGVH transcription in the presence or absence of calcium and is necessary for lcrG protein expression in the absence of calcium.  Plays an important role in the regulation of the low-calcium response (By similarity).
What are the official names of this protein?
Low calcium response locus protein R.
Protein: UREE_RHIME
Sequence: MPYRSTEVLSPGPGERAPLHRLTLTHEQRHLRRKLLHLENDDVVMLDLKEPVMLADGDLLVLEGGGHIEVKAAAEALYDIRARNPLHLMELAWHLGNRHLPAAVEEGRILIARDPVIRAMLEGLGATVDEVNEPFHPLHGAYHQHGHGDHYRHG
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLIN1_RAT
Sequence: MSMNKGPTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYNSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKGTISTRLRSARNSISVPIASTSDKVLGATLAGCELALGMAKETAEYAANTRVGRLASGGADLALGSIEKVVEYLLPPDKVESAPSSGRQKTQKAPKAKPSLLRRVSTLANTLSRHTMQTTARALKRGHSLAMWIPGVAPLSSLAQWGASAAMQVVSRRQSEVRVPWLHNLAASKDENHEDQTDTEGEETDEEEEEEESEAEENVLREVTALPTPLGFLGGVVHTVQKTLQNTISAVTWAPAAVLGTVGRILHLTPAQAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFQDIDNPPAEVERKGSGSRPASPESTARPGQPRAACAVRGLSAPSCPDLDDKTETSARPGLLAMPREKPARRVSDSFFRPSVMEPILGRTQYSQLRKKS
What is the function of this protein?
Modulator of adipocyte lipid metabolism.  Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL).  Its absence may result in leanness.  Plays a role in unilocular lipid droplet formation by activating CIDEC.  Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer.  May modulate lipolysis and triglyceride levels (By similarity).
What are the official names of this protein?
Perilipin-1, Lipid droplet-associated protein.
What is the protein family that this protein belongs to?
Belongs to the perilipin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Lipid droplet. Note=Lipid droplet surface-associated.
Protein: ISPD_ALIFM
Sequence: MALTTPLSITAIVPAAGVGSRMKADRPKQYLLLNGKTVLEHTIEQLLAFPLVNKVVVAITDGDPYFPELTLAQDNRVIRVSGGKERADSVLSGLSYVQEHQLSEWVMVHDAARPCVRHSDIDKLITEVIPEHIGGILASPVRDTMKQATQEQCIETTIDRSVLWHALTPQLFTTELLYSALQTGLDKNLSITDESSAIELMGYQPKLVQGRADNLKITQPEDLDLAEFYLQKMKKETK
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: NLEE_ECO57
Sequence: MINPVTNTQGVSPINTKYAEHVVKNIYPEIKHDYFNESPNIYDKKYISGITRGVAELKQEEFVNEKARRFSYMKTMYSVCPEAFEPISRNEASTPEGSWLTVISGKRPMGQFSVDSLYNPDLHALCELPDICCKIFPKENNDFLYIVVVYRNDSPLGEQRANRFIELYNIKRDIMQELNYELPELKAVKSEMIIAREMGEIFSYMPGEIDSYMKYINNKLSKIE
What is the function of this protein?
Cysteine methyltransferase effector that inhibits host cell NF-kappa-B activation by preventing nuclear translocation of host protein RELA/p65.  Acts by mediating cysteine methylation of host proteins TAB2 and TAB3: methylation of a conserved cysteine residue of the RanBP2-type zinc finger (NZF) of TAB2 and TAB3 disrupts zinc-binding, thereby inactivating the ubiquitin chain-binding activity of TAB2 and TAB3, leading to NF-kappa-B inactivation.  Also mediates cysteine methylation of host protein ZRANB3, inactivating its ability to bind ubiquitin chains.
What are the official names of this protein?
Cysteine S-methyltransferase NleE, Effector protein NleE, Non-LEE-encoded type III effector E.
What is the protein family that this protein belongs to?
Belongs to the NleE/OspZ family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Note=Secreted via the type III secretion system (TTSS). Localizes in the nucleus of the infected cells.
Protein: RSLBB_BOVIN
Sequence: MRLIQNMCTIAEYPAPGSAAAADCCLGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYERNAGNLYTRQVQIEGETLAIQVQDTPGIQVHENGLSCTEQLNRCIRWADAVVIVFSITDYKSYELTSQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVSVSENDNDVYNAFHVLCKEVSHKQQPSGTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRTVTSV
What are the official names of this protein?
Ras-like protein family member 11B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
Protein: TRUA_PETMO
Sequence: MKWVAATVMYDGSNFYGYQSQPTFRTVQDEFEKALKVIFKKEIPSYACGRTDTGVHAVGQVISFKVENENMTEKNIKDALNAILPEDVYVKEVKEVKEGFNPRAEAKKRIYHYFIYISEDPNIFLRDRVWWIPFALNLEKMRQAAKYFEGEHDFTSFKTGNDERNPIRTIYRVRIIELRKDLILIRVEGKSFLKRMVRNIVGSLVKVGTDVWEVEKIQEILEAKKRALAPASAPAQGLYFYSALF
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: ACPS_MYCPN
Sequence: MILGIGIDLVEIKRFEQLARQTDNCFAKRLLTSTEYAHYAKLRKDSEKSSFLAVHWSLKEAIYKAVNHIKPLFSQLEITKKNQRYNCQIDPKIELLLSVSYSSNNITAICLAQQTPWKN
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SESN2_HUMAN
Sequence: MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT
What is the function of this protein?
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190, PubMed:31586034, PubMed:35114100).  In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190, PubMed:31586034, PubMed:35114100).  Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190, PubMed:35114100).  This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses.  May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615).  May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085).  May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468).  Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684).  Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503).  However, this could not be confirmed (PubMed:19113821).
What are the official names of this protein?
Sestrin-2, Hypoxia-induced gene.
What is the protein family that this protein belongs to?
Belongs to the sestrin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y_BPPHM
Sequence: MLYLSELTILSITTGSETKILSEKSPFLKETDQTTTRTINYSKPQNRTTTSQAHYLGHKKAWL
What are the official names of this protein?
Uncharacterized protein Y.
Protein: IDI2_LIMRJ
Sequence: MMESRHAQRKNEHLSLAAKYYDQVHQHHYFDQVRLIHDSLPEMTTDDVDLHVQLADNLEIECPFYIEAMTGGSDQALKINRQLAQLAHKHHLAMATGSLSIISKDPQSFSSFEIIREENPDGIIFANLSANASLDQAINAISLLKANALELHINAAQELIMPEGDRDFNWLDNIQYLVSELEVPVIVKEVGFGMSKTTIAKLQTHDVHLINVSGRGGTNFAAIENRRNHDINFESLLDWGQTTPESLLEAHSIRRGKTEIIASGGITSPLDVIKAGVLGARAVGVAGYFLNILQNEGYEALDQTLGEWQVIVKRLLALLGCSSFTELSRVEYVLGTDLLSYARQRHLR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMH_SHESW
Sequence: MKLQLIAVGTRMPDWVTRGFEEYQRRFPRDMALELIEIPAGKRGKNADIVRILQKEGEQMLAAIPKGNHIVSLDLPGKNWTTPELATALSKWQLDGRDVSLLVGGPEGLAPACKDAAHQSWCLSALTLPHPLVRIVVAESLYRAWSVNTNHPYHRE
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_IGNH4
Sequence: MSDFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYEAADVIYHLMVLLALRGVDWAEVIKELERRSRAKSGAGGNS
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAA_YERP3
Sequence: MTNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGIYQSFLDIPVSIKIASLDISKPLLLWINDGLMAVFFLVVGLEVKRELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALAIIDDLGVIIIIALFYTQQVSLQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLHTQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGKPLGIFTFSWLAVKLGIAKLPDAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTYSKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: URE1_PSET1
Sequence: MKISRQAYADMYGPTTGDRIRLGDTELWVEIEHDHTHYGEEVKFGGGKVIRDGMGQSQRCDDAVMDTVITNAVIIDWWGIIKADVGLKNGRIAAIGKSGNPDTQPDIDIIIGPGTEIIAGEGQILTAGGVDTHVHYICPQQVDEALMSGLTTMIGGGTGPATGSVATTHTPGPWHLGKMMQAVDDLPINIGFLGKGSASTPEALEQQIKAGAMSLKIHEDWGAAPASISNALDVADRYDIQVAIHADSLNESGFVQDTLEAFKDRCIHTYHTEGAGGGHAPDIIVACAMPNVLPSSTNPTRPYTINTVDEHLDMLMGCHHLDPNIPEDVAFADSRIRRETIAAEDILHDMGVISMMSSDSQAMGRIGEVVCRTWQTAHKMRVQRGLLPEDEALGADNFRAKRYIAKYTINPAITHGISHEVGSIEVGKFADLVLWKPPFFGVKPSIILKGGMIAGAAMGDPNAAISTPQPVHYRRMFGALGKAVSATRMTFVSQAAMNTGLEEKLGLKSQLVACKNVRQVRKCDMKLNDACPVLTVDPQTYEVHADGVLLTCEPATELPLAQRYHLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.