PharMolix/UniProtQA huggingface dataset:
Protein: EIF3D_NEMVE
Sequence: MAGKAKFCAPEIQDNPDGWGPCSVPTAFKDIPYQPFSKADRLGKVSDWTGSVYQDRRYANKYQSQFGTGNQMFSYYHEEDETSFQLVDTSRTQRPGYMRNRNRFNQRGGYRRDNRGGRFQGQGGNMGMQNLSRGRDTRNKFQRKMQRNWGGGRHWSDKKTGGMHKRVASVTVREEWKVLEDGELDFPRLSKLNLPNVEEPETLYECGSVEYYDKAYDRVTTKNEVPLVGVNRVFHKVTTTDDPIISKLLSQGNVFATDAIISTLMTCTRSNYSWDIVVQRVGSKLFFDKRDDSEFDLLTVGETANDLNIDETSGINTPTNLSLEATFINQNFSQQVLKRGEVKTFDHPNPFVTDEDDSTVASVCYRYRKWDLGDGIQLIVRCEHDAIMQGPRGETCLVNIKTLNEWDPKMTGVDWRQKLDSQRGAVLATELKNNSCKLAKWTANSILAGSEYLKLGYVSRVNFLDTSKHTILGTQQFRPREFATQIALNMDNAWGVLRCIIDICMKQPEGKLLILKDPSKGVIRIYDIPNSTFETDEEDDDDDEDDVENDDGDDEKDEGDGED
What is the function of this protein?
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit D, eIF3d, Eukaryotic translation initiation factor 3 subunit 7.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2R40_PAPHA
Sequence: MATMNTDATDKDISRFKVIFTLVVSGIECITGILGSGFITAIYGAEWARGKTLPTGDCIMLMLSFSRLLLQIWMMLENIFSLLFRIVYNQNTVYILFKVITVFLNHSNLWFAAWLKVFYCLRIANFNHPLFFLMKRKIIVLMPWLLGLSVLVSLSFSFPLSKDVFNVYVNSSIPIPSYNSTEKKYFSETNXVNLVFFYNIGIFIPLIMFILAATLLILSLKRHTLHMGSNATGSRDPSMKAHIGAIKATSYFLILYIFNAVALFLSMSNIFDTYSSWNILCKIIMAAYPXGHSIQLILGNPGLRRAWKRFQSQVPLYLKGQTL
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 40, T2R40.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TIG_LEPCP
Sequence: MAVTVETLDKLERRITLTLSADELKNEVESRLKKLARTTKADGFRPGKVPMSVVAQRYGYSVQYEVMNDKVGQAFAAATGEAQLRVAGTPRITEKDGSADGQVSFDATFEVYPEVTIGDLSALEVERVTTEVTDVAIDRTLDILRKQRRTFADRPQGEYAVDGDRVTIDFEGKIDGETFQGGKAEAFQFILGEGRMLEAFEKAVRGMKTGESKTFPLAFPADYHGADVAGKEADFLVTLTRIEAQNLPEVDAAFAESLGIADATVDGLRADIKKNLEREVKFRVAARNKQSVMSALEKVATFDLPKALVDNEMARLVENARADLKQRGIADADKAPIPTEMFQPQAERRVRLGLTMAELVRANALSATMEQIKAHIDEMAQSYEKPEEVVRWYFGDQQRLSEVEAVVIEANVANFVLGQAQVVDKQLPFDELMGA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: CPP1_ENTH1
Sequence: MFTFILMFYIGYGIDFNTWVANNNKHFTAVESLRRRAIFNMNARIVAENNRKETFKLSVDGPFAAMTNEEYNSLLKLKRSGEEKGEVRYLNIQAPKAVDWRKKGKVTPIRDQGNCGSCYTFGSIAALEGRLLIEKGGDSETLDLSEEHMVQCTREDGNNGCNGGLGSNVYNYIMENGIAKESDYPYTGSDSTCRSDVKAFAKIKSYNRVARNNEVELKAAISQGLVDVSIDASSVQFQLYKSGAYTDKQCKNNYFALNHEVCAVGYGVVDGKECWIVRNSWGTGWGEKGYINMVIEGNTCGVATDPLYPTGVEYL
What is the function of this protein?
Cysteine protease which degrades matrix proteins such as collagen, laminin and fibronectin and thus is involved in the destruction of human tissue (PubMed:2557443).  Can abolish adhesion (PubMed:2557443).  May play an important role in pathogenicity (PubMed:2557443).
What are the official names of this protein?
Cysteine proteinase 1, EhCP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: SECA_AQUAE
Sequence: MLGWIAKKIIGTKNEREVKRLRKFVNQINELEKELDALTNKELVELAQELHDKIRFDEELKERVIKGEITPEVIKAFALVREAAKRTLGLRHFDVQLIGGLVLHEGKIAEMKTGEGKTLVATSPAVVNGMTDEGVHIVTVNDYLARRDAQWMGPIYKFLGLEVGVINSDGKTYLVEWVDPEKVKEAIENDVRVWPKGYYEEILPSEKVNIDAKKTYFTTLKEAEHRRKAYEAHITYGTNNEFGFDYLRDNLAFSKEEIVQVKGHNYAIVDEVDSILIDEARTPLIISGPAQIDSQIYHVADAVVRKLKKDKDFTVDEKNRTVNLTEQGIKKVEKMLGIDNLYDLKHVDLLHAILQSIRAHHLFKKDVHYIVRDGEVLIVDEFTGRVLPGRRWSDGLHQAIEVKEGVPVKEENQTLASITFQNYFKLYRKLAGMTGTAETEALEFKEIYGLDVVVIPTHKPMIRKDHPDLVFKTKEEKWERVVEEVLLNHIFGRPVLVGTVSIEDNEKLSSLLKNKKLLKEIANRNSFKRRLEETAKNLGVSPEEVQKKLEEVLKKGIPHNVLNAKHHEREAEIIAQAGRVGAVTIATNMAGRGTDILLGGNPEYLAKQMLKEKGINPEEATEEQFREALREAYRITEEEKEKVKKLGGLLVIGTERHESRRIDNQLRGRAGRQGDPGESRFIVSLEDDLLRLFGGERVSKLMDMLKIERGEPIESRMVSKALENAQKRVEAQNFQIRKRLYEFDSVMNIQRDVVYTLRRQLLEGENVHEKIKEFLKDIITQKVNELLPEDDPELWDLEPLKAFLKELTGREVEIPQVRDKEELIQKLYEELLKIYEEKEKEIGSPEAMRELERVILLNLLDNAWREHLHTLDRLREGIYLRGYAGKDPLIEYKREAYELFENMMENVKLNTLMTLFNVQIKSEEEIKEVEHEEEKKHQRLLEEAELQGVQGKSDKKPRPKTLKERLKEERLRKRKLKAKKKEQE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CH60_SALTI
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIITEGLKAVAAGMNPMDLKRGIDKAVAAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKIADLKGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKSDAPDLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_STAAB
Sequence: MKVVVQRVKEASVTNDTLNNQIKKGYCLLVGIGQDSTEQDADVIAKKIANARLFEDDNNKLNFNIQQVNGEILSVSQFTLYADVKKGNRPGFSNSKNPDQAVKIYEYFNDALRAYGLTVKTGEFGTHMNVNINNDGPVTIIYESQDGKIQ
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2A6_GLOHA
Sequence: NLLQFEKMIKKMTGKEPVVSYAFYGCYCGSGGQGKPKDATDRCCFVHDCCYGKVTGCDPKMDVYSFSEENGDIVCGGDDPCKKEICECDRAAAICFRDNLNTYNDKKYWAFGAKNCPQEESEAC
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 BA2, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GUAA_HELAH
Sequence: MIVVLDFGSQYTQLIARRLRESGIYAEIVPFFESTENIQKKAPKGLILSGGPASVYAKDAYTPSEKIFDLNLPILGICYGMQYLVDFFGGAVACANEQEFGKAALEIIQDSVIFKGVKAKSLVWMSHMDKVITLPKGFTTIAKSPNSLHCAIESGKVFGLQFHPEVIQSEEGGKILENFALLVCGCEKTWGMQNFAQKEMTRLKEKISDARVLCAVSGGVDSTVVATLLHRAIKDNLIAVFVDHGLLRKNEKEKVQAMFKDLQIPLNTIDAKEIFLSKLKGVSEPELKRKIIGETFIEVFEKEAKKHHLKGKIEFLAQGTLYPDVIESVSVKGPSKVIKSHHNVGGLPEWMDFKLIEPLRELFKDEVRLLGKELGVSQDFLMRHPFPGPGLAVRILGEVSESKIKCLQEADFIFIEELKKANLYDKVWQAFCVLLNAHSVGVMGDNRTYENAICLRAVDASDGMTASFSHLGHSFLEKVSNRITNEVSGINRVVYDITSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: Y1171_PROMH
Sequence: MKMICAIYRSTKRDQTYLYIEKKDDFSRIPEELLQSFGEPQFAMLLDLAQRQRLANADIEKVKQALTDQGFYLQVPPPVESMLNAYLDELKNSEKTE
What are the official names of this protein?
YcgL domain-containing protein PMI1171.
Protein: KPTA_AGRFC
Sequence: MSTATSKFLSYVLRHAPESIGLVLDSQGWADVADLLAKANASGTPLDEAGLRAVVAESDKKRFTLSEDGRRIRAAQGHSVKVDLGQPPVEPPPQLFHGTATRFLEPILREGLRPGERQQVHLSADRTTALAVGQRHGKPVVLIVDAGQMFADGCRFYLADNGVWLTDAVPFSYLTVSADSSAENDR
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: YTFH_SHIFL
Sequence: MSQVSLSQQLKEGNLFAEQCPSREVLKHVTSRWGVLILVALREGTHRFSDLRRKIGGVSEKMLAQSLQALEQDGFLNRIAYPVVPPHVEYSLTPLGEQVSEKVAALADWIELNLPEVLAVRDERAA
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YtfH.
Protein: VATA_NITMS
Sequence: MAAQGRIVWVSGPAVRADGMSEAKMYETVTVGDSKLVGEVIRLTGDVAFIQVYESTSGLKPGEPVIGTGNPLSVLLGPGIIGQLYDGIQRPLRALSEASGSFIGRGITTTPVDMAKKYHFVPSVSNGDEVAAGNVIGVVQETDLIEHSIMVPPDHKGGKISNLVSEGDYDLETVLATTEGEGETVELKMYHRWPVRKPRPYKNRYDPTVPLLTGQRVIDTFFPIAKGGTGSIPGAFGTGKTVTLHQIAKWADSQVVVYIGCGERGNEMTEVLVEFPHLKDPRSGKPLMDRTVLVANTSNMPVAAREASIYTGVTIAEYYRDMGKDVVLVADSTSRWAEALREMSGRLEEMPAEEGYPSYLASRLAEFYERAGRVRAAGSPDRDGSVTLIGAVSPSGGDFTEPVTTHTMRFIKTFWALDAKLAYSRHYPSINWMNSYSGYLADIAKWWGENINEDWLSLRSEVYGVLQREDTLKEIVRLLGPEALPDEEKLILEVARMVKIGLLQQNSFDDVDTYCSPEKQYKLMKLLVDFYKKGQQAIKEGTPLADIRAMKSITTLLKARMDVKDDEMPKLDQLDADMQEEFKSITGVKVSN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: REXO4_XENTR
Sequence: MAKAKVKQDQSPSGSALGKAANSQKQTKKQKKKKFWKNHPKIAGKTSEAKTLFPLLPPKQPQEFSSNWKALQELLKPKLNPAAPATPSEKFPKKDQKVSEKKNGDPEPPKSTPKINGGITSVTPKEAKAPSQAPPTKAVEVKKEKKRKIKAEGTEQLDPPKKPQGGTQPEPPKVDIWFDDVDPDDIEAALGPEAGRIAREMQGVTETAPPTAEKVLVKEKAFEGLTRTVAMDCEMVGVGLDGEESMLARVSIVNLFGKCVYDKYVRPTERVTDYRTAVSGIRPDDIKNGEAFKDVQAEVAEILRGRTLVGHAVHNDLKILFLDHPKKAIRDTQKYKPFKEKVKSGRPSLKLLCEKILNVKVQTGEHCSVQDAQAAMRLYTMEKKCWEAAIKAKYAGVTAAKAKGPQKDKQPPAQ
What are the official names of this protein?
RNA exonuclease 4, Exonuclease XPMC2, Prevents mitotic catastrophe 2 protein.
What is the protein family that this protein belongs to?
Belongs to the REXO4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNAA_SULDN
Sequence: MNIGEKILLLLKEEIPEIEYNRYIKHLTYDTKKSTADNAIFYVPNSLVLSWIKNRYSSKIKHLFEIQNSIKVDVSILLKNQVESKKAEQKSVQKQQHSLLNPSHTFENFMVGGSNQFAYAAVKSVSEKAGVLYNPLFIHGGVGLGKTHLMQAAGNVFQNQGKVVIYTTVEQFLNDFIRHVRNKTMERFQEKYRKCDVLLIDDIQFLSNKEGIQEEFFHTFEALKGVGKQIILTADKHPKKIAGLEKRLQSRFEHGLVADIQPPELETKIAIIENKCKINKVILTKDIIHYIATVIESNVREIEGILSKLHAYSQLMHVDIDLQFTKNVLKDQLQENRANLTLDIITQNVAKDLNIKPSEIRSKGRSKNLVYARRIAIYLCRELTQNTMPQLAQYFGMQDHTAISHTLKKIGELMQNDEDFKVKIEELTNKITSSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBA1_ARCGA
Sequence: MVLSPADKTNIKTTWDKLGGHAGEYGGEALERTFMSFPTTKTYFPHFDLSPGSAQVKAHGKKVADALTTAVAHMDDLPKALSALSDLHAYKLRVDPVNFKLLSHCLLVTLACHHPAEFTPAVHASLDKFFSTVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1, Alpha-1-globin, Hemoglobin alpha-1 chain, Hemoglobin alpha-I chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: METJ_HISS2
Sequence: MADWDGKYISPYAEHGKKSEQVKKITVSIPIKVLEILTNERTRRQLRNLRHATNSELLCEAFLHAFTGQPLPTDEDLLKERHDEIPESAKQIMRELGINPDDWEY
What is the function of this protein?
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
What are the official names of this protein?
Met repressor, Met regulon regulatory protein MetJ.
What is the protein family that this protein belongs to?
Belongs to the MetJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_FRSF5
Sequence: MKGPAFSKPLKDKINPWGPLIVLGILIRAGVSVQHDSPHQVFNVTWRVTNLMTGQTANATSLLGTMTDAFPMLHFDLCDLIGDDWDETGLECRTPGGRKRARTFDFYVCPGHTVPTGCGGPREGYCGKWGCETTGQAYWKPSSSWDLISLKRGNTPKDRGPCYDSSVSSGVQGATPGGRCNPLVLKFTDAGKKASWDSPKVWGLRLYRPTGIDPVTRFSLTRQVLNIGPRIPIGPNPVIIGQLPPSRPVQVRLPRPPQPPPTGAASMVPGTAPPSQQPGTGDRLLNLVQGAYQALNLTNPDKTQECWLCLVSGPPYYEGVAVLGTNSNHTSALKEKCCFYADHTGLVRDSMAKLRKRLTQRQKLFESSQGWFEGSFNRSPWFTTLISTIMGLLIILLLLLILLLWTLHS
What is the function of this protein?
This envelope-like membrane glycoprotein is responsible for ligand-independent activation of the erythropoietin receptor EPOR leading to the abnormally rapid proliferation of erythroid precursor cells.  In the first stage of Friend disease, constitutive activation of EPOR by gp55 causes uncontrolled, polyclonal proliferation of infected erythroblasts, leading to polycythemia (massive increase in the number of mature red cells).  Host susceptibility to SSFV-induced erythroblastosis depends on the expression of the truncated isoform of MST1R receptor tyrosine kinase (MST1R isoform sf-Stk).  Interaction with SSFV gp 55 results in constitutive tyrosine phosphorylation and activation of MST1R isoform sf-Stk.
What are the official names of this protein?
Glycoprotein 55, gp55.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Virion membrane; Single-pass type I membrane protein. Note=The envelope-like membrane glycoprotein gp55 is defective in its transport to the cell surface and remains associated predominantly with the rough endoplasmic reticulum (RER) membrane. It is almost not incorporated into virions. Host cell surface expression appears to be a prerequisite for its leukemogenicity.
Protein: TSG6_MOUSE
Sequence: MVVLLCLCVLLWEEAHGWGFKNGIFHNSIWLEQAAGVYHREARAGRYKLTYAEAKAVCEFEGGRLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKRIFKSPGFPNEYDDNQVCYWHIRLKYGQRIHLSFLDFDLEHDPGCLADYVEIYDSYDDVHGFVGRYCGDELPEDIISTGNVMTLKFLSDASVTAGGFQIKYVTVDPASKSSQAKNTSTTGNKKFLPGRFSHL
What is the function of this protein?
Major regulator of extracellular matrix organization during tissue remodeling (By similarity).  Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan.  Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan.  In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin (By similarity).  Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization (PubMed:12668637).  Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling.  Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation.  Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling (By similarity).  Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation.  In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium (By similarity).  Has a role in osteogenesis and bone remodeling.  Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts.  Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation (PubMed:18586671) (By similarity).
What are the official names of this protein?
Tumor necrosis factor-inducible gene 6 protein, TNF-stimulated gene 6 protein, TSG-6, Tumor necrosis factor alpha-induced protein 6, TNF alpha-induced protein 6.
What are the subcellular locations of this protein?
Secreted.
Protein: SCF_MOUSE
Sequence: MKKTQTWIITCIYLQLLLFNPLVKTKEICGNPVTDNVKDITKLVANLPNDYMITLNYVAGMDVLPSHCWLRDMVIQLSLSLTTLLDKFSNISEGLSNYSIIDKLGKIVDDLVLCMEENAPKNIKESPKRPETRSFTPEEFFSIFNRSIDAFKDFMVASDTSDCVLSSTLGPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKAAKAPEDSGLQWTAMALPALISLVIGFAFGALYWKKKQSSLTRAVENIQINEEDNEISMLQQKEREFQEV
What is the function of this protein?
Ligand for the receptor-type protein-tyrosine kinase KIT.  Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.  KITLG/SCF binding can activate several signaling pathways.  Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1.  KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1.  KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.  KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  KITLG/SCF acts synergistically with other cytokines, probably interleukins.
What are the official names of this protein?
Kit ligand, Hematopoietic growth factor KL, Mast cell growth factor, MGF, Steel factor, Stem cell factor, SCF, c-Kit ligand.
What is the protein family that this protein belongs to?
Belongs to the SCF family.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single- pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, filopodium. SUBCELLULAR LOCATION: [Soluble KIT ligand]: Secreted.
Protein: DNLJ_ECOSM
Sequence: MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKSNEKVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGENIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGSDVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPEPIVINAEEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIEVIDETEMLRLLGS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: IKBG2_MDBVW
Sequence: MLAKSGFKIVLNGCLNDRGDNLAHYFSRQGDVIDLIALKEVINDDNRHLLLDYNFSQRQCVHIVVCEDKVNAIKKLKVLLEMGADINGQERKGGNTPLHLAVHSNNYKLVKWLCKQPSINKTALNYAQKTPHDIAIERIEKKINNALMEQKKWYKIMHPSGADLSEEE
What is the function of this protein?
Suppresses the host immune response through NF-kappa-B inactivation.  Possesses ankyrin repeat domains required for NF-kappa-B binding but lacks the regulatory regions required for dissociation from NF-kappa-B and degradation.  Therefore, prevents host NF-kappa-B release and subsequent activation (By similarity).
What are the official names of this protein?
I-Kappa-B like protein G2.
What is the protein family that this protein belongs to?
Belongs to the polydnaviridae I-Kappa-B-like protein family.
Protein: RL20_CHLTR
Sequence: MVRATGSVASRSRRKRVLKQAKGFWGDRKGHFRQSRSSVMRAMAFNYMHRKDRKGDFRSLWITRLSVASRIHGLSYSRLINGLKQAGIHLNRKMLSEMAIHDPQGFAVVATQAKLALEAAVQG
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: RK33_ZYGCR
Sequence: MAKNKEIRINVTLECTNCANNSQKSSRGISRYITQKNRRNTPNRLELNKFCPYCVGHTVHKEIKK
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BETB_BURA4
Sequence: MSVYGLQRLYIGGGYVDATSGKTFDTFDPATGELLAQVQQASAADVDRAVASAREGQREWAAMTAMQRSRILRRAVDLLRERNDELAAIETRDTGKPIGETLAVDIVTGADVIEYYAGLATAIEGLQVPLRAESFVYTRREPLGVCAGIGAWNYPIQIACWKTAPALAAGNAMVFKPSEVTPLTALKLAEIYTEAGVPAGVFNVVQGDGSVGALLTGHPDIAKVSFTGGVETGKKVMSLAGASSLKEVTMELGGKSPLIVFEDADLDRAADIAVTANFFSSGQVCTNGTRVFVHRSVKDAFTQRVLERVKRIRVGKPTDADTNFGPLVSAAQLDKVLGFIDSGKAEGAKLLAGGTRLTDGHFGSGQYVAPTVFGDCRDDMKIVREEIFGPVMSILDFESEDEVIARANDTHYGLAAGVVTENLSRAHRTIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQVELGRYNPVF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.