PharMolix/UniProtQA huggingface dataset:
Protein: DFRA_PYRCO
Sequence: MGSESESVCVTGASGFIGSWLVMRLLEHGYTVRATVRDPTNQKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIQGCSGVFHVATPMDFESRDPENEVIKPTINGLLDILKACQKAKTVRKLVFTSSAGTVNVEEHQKPVYDESNWSDVEFCRSVKMTGWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVIGPFLMPSMPPSLITGLSPILRNESHYGIIKQGQYVHLDDLCLSHIYLYKHPKAEGRYICSSHDATIHELVKMLREKYPEYNIPTKFKGIDDNLEPVHFSSKKLREIGFEFKYSLEDMFVGAVDACRAKGLIPIPAEKTEAAEESNLVDVKVGS
What is the function of this protein?
Bifunctional enzyme involved in the flavonoid metabolism.  May use dihydroquercetin, eriodictyol, garbanzol (5-deoxydihydrokaempferol), dihydrofisetin (5-deoxydihydroquercetin), dihydrokaempferol to a low extent (5%), but not naringenin, 5-deoxynaringenin or butin (5-deoxyeriodictyol) as substrate.
What are the official names of this protein?
Bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase, Dihydroflavonol 4-reductase, DFR, Flavanone 4-reductase, FNR.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
Protein: STAU2_DANRE
Sequence: MANPKEKTPMCLVNELARFNRIQPQYKLLNEKGPAHAKIFTVQLCLGNQVWESEGSSIKKAQHSTATKALAESSLPRPPPRSPKADSNSNPGSITPTVELNGLAMKRGEPAIYRPLDPKPIPNYRANYNFRGMFNQRYHYPVPKVFYVQLTVGNNEFIGEGRTRQAARHNAAMKALQALKNEPIPERPPQCSEEKKETEENSDASKSEISLVYEIALKRNLPVNFEVLKESGPPHMKSFLTRVTVGEFSAEGEGNSKKLSKKRAALSILQELKKLPVLPVVEKPKVHYKKRPKTILKTGPEYGQGMNPISRLAQIQQAKKEKEPEYMLLSERGMPRRREFIMQVKVGTEVTTGTGPNKKVAKRNAAEAMLLQLGYKASTPLQNTPEKMDNKGWNGQRAAFPETTSNTQKGILHLSPDVYQEMEASRNKGVPGAPGNFPTAKEIGQGSAGPFCTPSVGNTATIAKELLLSGTSPTAEALVLKGKAPALACGSIQPSQQLEYLAHIQGFQVQYSDRQTDKEFMTYLTLSPVQMTFHGIGSSIPASHDQAALSALKQLSEQGLDPVDGPIKVENGSCDIQAKRLAERTESKPTNSGTTAQDCKDSKAVV
What is the function of this protein?
RNA-binding protein required for the microtubule-dependent transport of RNAs within polarized cell types.
What are the official names of this protein?
Double-stranded RNA-binding protein Staufen homolog 2.
Protein: SODC_IPOBA
Sequence: MVKAVAVLSSSEGVSGTIFFSQEGDGPTTVTGNVSGLKPGLHGFHVHALGDTTNGCMSTGPHFNPAGKEHGAPGDDNRHAGDLGNITVGEDGTASFTITDKQIPLTGANSVIGRAVVVHGDPDDLGKGGHELSKSTGNAGGRVACGIIGLQG
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQRB_CHLTA
Sequence: MLEKLVDSLWKICRKSKFQHMTPIADAVDTFCFEPLHTPSSPPFVRDAVDVKRWMMLVVIALMPTIFAAVWNSGLQALVYQSSDPRIMEAFLHISGFKSYFSFVSQEIGIGSVLFAGCKIFLPLLFISYAVGGTCEVLFAIIRKHKIAEGLLVTGMLYPLILPPTIPYWMAALGIAFGVVMGKELFGGTGMNILNPALTGRAFLFFTFPAKMSGDVWVGSNPSRIKESLATMSSLAEKSHFDGFSQSTCLQVLNSTPPSVKRVHIDAIASNILNLEHVPTQDVLQTQFATWAESYPGLTVDQLSLEQLQNFVTTPITEGGLGLLPAHFDSACSLTEAVYGIGKFSTGNLFFGNILGSLGETSTVACLLGAGLLLLTGIASWRTMLSFGLSAFFFAWFFKIMSILTTGNAGAWAPAKFFIPAYRHLCIGGLAFGLVFMATDPVSSPAMKLAKWLYGAFIGFLTILIRLINPAYPEGVMLAILLGNVFAPLFDNIALKQYRQRRI
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit B, Na(+)-NQR subunit B, Na(+)-translocating NQR subunit B, NQR complex subunit B, NQR-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DEF02_ARATH
Sequence: MKLSMRLISAVLIMFMIFVATGMGPVTVEARTCESQSHRFKGTCVSASNCANVCHNEGFVGGNCRGFRRRCFCTRHC
What is the function of this protein?
Confers broad-spectrum resistance to pathogens.
What are the official names of this protein?
Defensin-like protein 2, Low-molecular-weight cysteine-rich protein 69, Protein LCR69, Plant defensin 2.2.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: YANC_ASPNA
Sequence: MALVHLTALAACGLLLVILRAAFNSWRLQRKLPPGPPGAPLIGNILQLPKVRAHQKFTEWARTYGGLYSFRIGPATAAVVTDRALVKELFDKRSALYSSRPTSYVGQNIITRGDHLLVMDYSDNWRLFRKAINQHFMASMCEKTHVRLLEAEHTQMMRDFLLHPEKHMLHTKRTTNSIIMSLLFGIRTPSWDTPHMQELYEIMEIWSQIMETGATPPVDIFPWLHWVPQQWLGHWVDRSQTVARGMKRLYSSFHRRAIEARRKAESTSQSRARTFLDDVLDLQEKLGLTDNQVDFLGGVMMEGGSDTGSTMLLVMIQALALHPEIQQRARAELDAVCGEHRSPTWEDFPRLPYINMIVKETMRWRPVTPLAFPHALNKDDWVNGYFLPKGTTVFLNVWGLHHDENIFPNPDQFDPSRFEGRHKLAFDYAASPDYMQRDHYIYGAGRRLCPGIHLSERSMFLGAAKLLWAFNFEPARDEDGNPIRIDTDPVTGYTEGFLVCPRPYQCNVTPRSPAHAETILREFSRAESEVLSQYAMP
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of yanuthone D, a fungal isoprenoid epoxycyclohexenone that acts as an antibiotic against fungi and bacteria (PubMed:24684908).  The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase yanA (PubMed:24684908).  6-MSA is then converted to m-cresol by the decarboxylase yanB (PubMed:24684908).  The cytochrome P450 monooxygenase yanC then catalyzes the oxidation of m-cresol to toluquinol (PubMed:24684908).  Epoxidation of toluquinol is then performed by the short chain dehydrogenase yanD, with the help of yanE, and a further prenylation by yanG leads to 7-deacetoxyyanuthone A (PubMed:24684908).  The next step is the hydroxylation of C-22 of 7-deacetoxyyanuthone A by the cytochrome P450 monooxygenase yanH to yield 22-deacetylyanuthone A (PubMed:24684908).  O-Mevalon transferase yanI then attaches mevalon to the hydroxyl group of 22-deacetylyanuthone A to produce yanuthone E (PubMed:24684908).  Finally, the FAD-dependent monooxygenase yanF oxidizes the hydroxyl group at C15 of yanuthone E to form yanuthone D (PubMed:24684908).  Furthermore, several branching points in the pathway lead to the production of yanuthones F and G from 7-deacetoxyyanuthone A; yanuthones H and I from 22-deacetylyanuthone A; and yanuthone J from yanuthone E (PubMed:24684908).  YanC is also involved in the synthesis of yanuthone X1 which does not have 6-methylsalicylic acid (6-MSA) as precursor (PubMed:24684908).
What are the official names of this protein?
Cytochrome P450 monooxygenase yanC, Yanuthone D biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: SELO_SYNY3
Sequence: MTNPFLNLTYEPALESLGNEFFDPVSAATFPEHKLRFRNDRLLPMLGLEPSQVKDDNFVEAFGLFHGVRPFLALRYHGYQFGEYNPNLGDGRGFLYGQVRGVNGELFDFGTKGSGQTPYSRGGDGRLTLKGGVREVLAAEALHRLGVKTSRCLSLVETGDSLWRGDEPSPTRASVMIRFSRSHIRFGTFERLHYHHQTEQIAQLLDHVIVTYYPEVSGSNSDDSAHIAFFRVLVERVAKLVAQWMAAGFCHGVLNTDNMSITGESFDYGPYGFVPTYDLNFIAAYFDYGGRYRFGNQPAVCRWNLERLQVSLSSVIPSKAMTEALEDYEKIYLGYYITLIARRLGISSTLGDRLDPELWEKLVGQTLQCLAQSQWSYPDFFAQLRLNFSPSWRDNADLILENVDLLGADWSTWRSIYQQVLKQLPPESLAAVPTVLEQANPLTDLLRPRIETVWQAIAEDDNWQPFNDLVQKLQSGN
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: RS15_ACTP7
Sequence: MSLSVEAKAKIVAEFGRDAKDTGSSEVQIALLTAQINHLQAHFAEHKKDHHGRRGLLRMVSRRRKLLDYLKRTDLAKYSETIARLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: COPE2_ORYSJ
Sequence: MAGAASPDHLFGLRNSFYVGAYQAVITGVQAIPARAALSPDALAERDSLLYRSYIAIGSHQLVIDEIGPGAATPLQAVRLLTVYLSGGAGGKESAIRKLNELLADDAVGSNPILRLVAGTVLMHERDYAGALKHTNSGGTMELLAMNVQICLQMHRSDHAEKQLRIMQQLDEDHTLTQLANAWVDLVMGGSKIQEAHLIFQDLSEKYPATCLILNGKALCLMHMGNFEDAEGLLLESLNKDAKDAETLANLVVCSLNLGKSASRYLNQLKLAHPDHMLVKRMSSAEDSFDRACQAIS
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit epsilon-2, Epsilon-coat protein 2, Epsilon-COP 2.
What is the protein family that this protein belongs to?
Belongs to the COPE family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: COX1_EQUAS
Sequence: MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMIEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPALSQYQTPLFVWSVLITAVLLLLALPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNQTWAKIHFTIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTISSMGSFISLTAVMLMIFMIWEAFASKREVSTVELTSTNLEWLHGCPPPYHTFEEPAYVNLK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UB2Q2_HUMAN
Sequence: MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPQQGSPHSLPPPLTLHCNITESYPSSSPIWFVDSEDPNLTSVLERLEDTKNNNLLRQQLKWLICELCSLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEEEEEEEEMAEDIEDLDHYEMKEEEPISGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTGIYSVELINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGGGALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes 'Lys-48'-linked polyubiquitination.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 Q2, E2 ubiquitin-conjugating enzyme Q2, Ubiquitin carrier protein Q2, Ubiquitin-protein ligase Q2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_CROS5
Sequence: MSAATDEILEKLKSLTLLEASELVKQIEEAFGVSAAAPSGGMMMMAPGAAAPGAAAAEPEEEKTEFDVILEEVPGDKKIAILKVVRGITGLGLKEAKDMVESTPKPIKEGTGKEDAEDIKKKLEEAGAKVSVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: APA2_YEAST
Sequence: MIEENLKQKIHDKFVAAKKNGHLKVTHAESKKLKDPQTTTQYWVTFAPSLALKPDANKNSDSKAEDPFANPDEELVVTEDLNGDGEYKLLLNKFPVVPEHSLLVTSEFKDQRSALTPSDLMTAYNVLCSLQGDKDDDVTCERYLVFYNCGPHSGSSQDHKHLQIMQMPEKFIPFQDVLCNGKDHFLPTFNAEPLQDDKVSFAHFVLPLPESSDQVDEDLLAMCYVSLMQRALTFFQDWTNESPELTKSYNVLLTKKWICVVPRSHAKSGPPLMLNINSTGYCGMILVKDREKLENLTEDPHLVDKSLLQCGFPNTAGQKPTEYHY
What is the function of this protein?
Ap4A phosphorylase catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP.  Can also use other Np4N' nucleotides (where N and N' stand for A,C,G or U) as substrates, but prefers A-containing substrates.  Cannot catalyze the reverse reaction.  Additionally, this enzyme can also catalyze the phosphorolytic degradation of adenosine 5'-phosphosulfate (AMPS) into ADP and sulfate, the reversible exchange reaction between inorganic phosphate and the beta-phosphate of a nucleoside diphosphate (NDP), and the synthesis of Ap4A from AMPS plus ATP.
What are the official names of this protein?
Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2, Ap4A phosphorylase 2, ADP-sulfurylase, ATP adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ATP adenylyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YR700_MIMIV
Sequence: MDYSHKYIKYKKKYLSLRNKLDRENTPVIISRIEDNFSIDDKITQSNNNFTNNVFYNFDTSANIFSPMSLTFSLALLQLAAGSETDKSLTKFLGYKYSLDDINYLFNIMNSSIMKLSNLLVVNNKYSINQEYRSMLNGIAVIVQDDFITNKKLISQKVNEFVESETNAMIKNVINDSDIDNKSVFIMVNTIYFKANWKHKFPVDNTTKMRFHRTQEDVVDMMYQVNSFNYYENKALQLIELPYNDEDYVMGIILPKVYNTDNVDYTINNVPMFSPAEINEFINNCQYSKVELYVPKFTQRKRYEFVPILKKMGLTHLFNKNDTDLNIMAKDAYISRIIHEAVVVIDEIGTEAAATTIVIGQAMATRPVKQKIKVFKADHAFIYYIRHQPTGLFLFFGDYQG
What is the function of this protein?
May act as an inhibitor for a host chymotrypsin-like protease.
What are the official names of this protein?
Uncharacterized serpin-like protein R700.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
Protein: NTPPB_ECOLI
Sequence: MPKLILASTSPWRRALLEKLQISFECAAPEVDETPRSDESPRQLVLRLAQEKAQSLASRYPDHLIIGSDQVCVLDGEITGKPLTEENARLQLRKASGNIVTFYTGLALFNSANGHLQTEVEPFDVHFRHLSEAEIDNYVRKEHPLHCAGSFKSEGFGITLFERLEGRDPNTLVGLPLIALCQMLRREGKNPLMG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP) (PubMed:24210219).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219).
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTHR_CANLF
Sequence: MLRRLVQQWGVAVFLLSYSVPSCGRSVEELGRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPAPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTRSAWLNSGVAESGLEGDHPYDISATSLELNLRRH
What is the function of this protein?
Osteostatin is a potent inhibitor of osteoclastic bone resorption.
What are the official names of this protein?
Parathyroid hormone-related protein, PTH-rP, PTHrP.
What is the protein family that this protein belongs to?
Belongs to the parathyroid hormone family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted.
Protein: NU5M_ALLMA
Sequence: MYLTIITLPLFAFLTVGVIGRKLGVRGSQIITSLSIIISAILSLYGFYEIVLLNNLGPITIYLSPWMNVIGAHADWAFYFDSISITMCVVVSSISSLVHLYSIGYMQGDPHIQRFFSYLSLFTFFMLLLVTGNNYLLMFVGWEGIGVSSYLLINFWFTRIQANKASMQAMLVNRVGDLGFVLGLFGIFWLFGSSDYDTVGIIAYKLDEQYITIVTLFLLIAAIGKSAQLGLHTWLPSAMEGPTPVSALIHAATLVTAGVYLILRSSPLFELAPTSLICVCVIGSLTAIFAATTGLFQNDLKRVIAYSTCSQLGYMVFALGLSQYEVAFFHLFNHAYFKALLFLSAGSIIHALHDEQDMRKMGGLVNILPFTYTMILIGSLSLMALPFLTGYYSKDAILEVAYGQFLVTGTFTYWLGTITATITAFYSSKALILGFFGTPNGSKKIYNTIHEAPLIMSIPLFLLSICSIFIGYITNKHLSVIGIGSSGIISGGVGTLRDHYLGFDIEFISTSFGVQFYPLFASLLGISLALIVLKDPKKMHSIEKPEGLLNTVNITRWLSSKSYWFDNVYNTVLISGSLHFGGIFARDIDKGFLSLLGPQGLQQLLITISRFFAIKIDTGFIPHYASIIIIIPIFIILSIFI
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MKS3_MOUSE
Sequence: MVTRTRPVAAMAVRSRSSSRTGTAYLLLVLCEVSWAQIFSFPFRRPETCDFNQYFDISALSCAPCGANQRRDALGTSCVCLPGYHMISNNGGPSIICKKCPENMKGVTKDGWDCISCPSGLTAEGKCHCPTGHILVERNVSGSLLAQATCELCDESENSFTKANALGTRCVRCEPTFVNTSRSCSCSEPHTLTGGLCFSNTGNFHQRVISTARYGELGMSLNSEWFAKYLQATAAACWTHANLTSCQALGNMCVMNMNSYDSTTLDACRLFHYIFESTAGLISVHSVPFWRQNLPWLFYGDQPGLAPQVLSTTPLPTNFSFKGQNQLKFVAASYDIRGNFIKWQPLEGGVLQLCPDTERRLDAAYAFGTTYQQNCEISLSKLLVDFSSPVFYDVYLEYTDEEQHRYLWPIPVLNLNLQHNKLFVNQDSSSSKWLLTRRIFLVDAVSGRENDLGNQPRVIRVATQISLSIRLVPNTKNGNIYTPLLTIAYSDIDIKNAHSQSAKISFSVKYEMNQGDASVHTDIALGVLGGLAVLSSLLKTAGWKRRVGSPMIDLQTVMKFLLYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPVQEERFVTYVGCAFAMKALQFLHKFISQISIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTTLFFLEVVGFKNLALMDSSSSLSRNPSDYTAPYSRILRYAVATAIWLVIGIIQVVFFAAFYERFIEDKIRQFVDLCSMSNVSVFLLSHRCFGYYIHGRSVHGHADTNMEEMNMNLKREAENLCSQRGLVPNTDGQTFQIAVSSQMRQHYDRIHETLTRRNGPARLLSSSGSTFEQSIKAYHAMNKFLGSFIDHVHKEMDYFIKDKLLLERILGMEFMEPMEKSIFYNDEGHSFSSVLYYGNEATLLIFDLLFFCVVDLACQDFVLASFLTYLQQEIFRFIRNTVGQKNLATKTLVDERFLI
What is the function of this protein?
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.  Involved in centrosome migration to the apical cell surface during early ciliogenesis.  Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication.  Is a key regulator of stereociliary bundle orientation (PubMed:26035863).  Required for epithelial cell branching morphology (PubMed:26035863).  Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc).  Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A (PubMed:26035863).  In non-canonical Wnt signaling, it may act as ROR2 coreceptor (PubMed:26035863).
What are the official names of this protein?
Meckelin, Meckel syndrome type 3 protein homolog, Transmembrane protein 67.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
Protein: GPI1_SCHPO
Sequence: MSTTTMNIASAPIEVKRIYWPKSTISYTDSGYLVGWKYSTNDLIVVTTITSYQSFANFLVDYCKNQDQSVDIKSLCILGTFNCSADILPGDKYEIDCWIKVQQSTELSHPRVFDSASTPLKINLHIIYYHPPQPRKMQFLSLEPLSLLLLKDSFINKSNPEYESMQHQQILLKKLKLHFPRRKENSWKRSLRSGLIELLNQSFEVRMLTHENNNKKNSYVFRLFDRVSSSTFYFFNSLFAYFIILLRIINEVILLAINYRPIPLSYNMMDIFVSARQVDLRLQQACFWPVQYMKLWVFRKSKRVAIEDYKEYIRFYNNLWLVANDMIFGITMSSFILENLHLVVKLIENITFEYAIKNVRSMVIWLVDTPAGLKLNNDICKFIMKLSVWVIDVWSNFLLHCLPWTPFLVQVVAISGFGGASLMIALISDFLSVMTIHIHLLYLASSRLYNWQLRVIYSLLQLFRGKKRNVLRNRIDSYEYDLDQLLLGTILFTVLIFFLPTIYVFYAAFALTRVSVMTCLAICETMLAFLNHFPLFVTMLRIKDPYRIPSGLNFEIVSFEPLKQDGFATLYLNCNSKPMSLGSMFEHYRKLARRLISHYLSKTTLISLLVGCPVPAIPAEQLYNIQYAMLPTKRISIRKLRDLLFHQKKFPYD
What is the function of this protein?
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
What are the official names of this protein?
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AROK_THIDA
Sequence: MSKRDNLYLVGLMGAGKTTVGRLLAKHYGCTFYDSDHEIEARTGVKIPVIFEIEGEAGFRRREEAVIAELTTLSGIVLATGGGAVLSPANREHLRTNGLVIYLRGSPEQLCERTRNDRNRPLLQTGNPLAKLRELYQQRDPIYRELADVTVDTARQSVAGMTRVLYGKLDLLKGEATSFDPAG
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXB_SHESR
Sequence: MSKKSQLVFAMVAGELSGDILGAGLMAALQKTHPNARFVGIGGPRMEALGFESLFAMEELAVMGIVEVLSRLPRLLHVRSSLIKSITELKPDCFIGIDAPDFNIGLELKLKAQGIKTVHYVSPSVWAWRPKRIFKIAKATNMVLSLLPFEKAFYDKHQVPCTFVGHTLADDIPLESDKASARQLLELDPDAEYLAILPGSRGGELKQLAEPFVKAALLIKQQFPDIRFVTPLVNQKRREQFEQALKAHAPDLEIHMVEGKSREVMAAADGILLASGTATLEAMLIKRPMVVAYRVSPLTYEIAKTMMQVNRFSLPNLLAGRDVVPELIQHDCTPEKIAAAVGVELNRDFAPIKAEFERLHQLLRCDASQKAAEAVLALVDAKELN
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: CYB_MYOMA
Sequence: MTNIRKSHPLMKIINSSFIDLPAPSNISSWWNFGSLLGICLALQILTGLFLAMHYTSDTATAFNSVTHICRDVNYGWILRYLHANGASMFFICLYLHVGRGLYYGSYMYTETWNIGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFLLPFIISAMVMVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGLLLMITVLLALVLFSPDMLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAAIPLLHTSKQRSMSFRPLSQCLFWLLVADLLILTWIGGQPVEHPYVIIGQLASILYFSTIIILMPLTSLLENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NIRC_ECOLI
Sequence: MFTDTINKCAANAARIARLSANNPLGFWVSSAMAGAYVGLGIILIFTLGNLLDPSVRPLVMGATFGIALTLVIIAGSELFTGHTMFLTFGVKAGSISHGQMWAILPQTWLGNLVGSVFVAMLYSWGGGSLLPVDTSIVHSVALAKTTAPAMVLFFKGALCNWLVCLAIWMALRTEGAAKFIAIWWCLLAFIASGYEHSIANMTLFALSWFGNHSEAYTLAGIGHNLLWVTLGNTLSGAVFMGLGYWYATPKANRPVADKFNQTETAAG
What is the function of this protein?
Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane.  Is up to 10-fold more active than NarK or NarU in nitrite uptake for subsequent reduction in the cytoplasm by the NirB/NirD nitrite reductase.
What are the official names of this protein?
Nitrite transporter NirC.
What is the protein family that this protein belongs to?
Belongs to the FNT transporter (TC 2.A.44) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.