PharMolix/UniProtQA huggingface dataset:
Protein: GLGC_SHIF8
Sequence: MVSLEKNDHLMLARQLPLKSVALILAGGRGTRLKDLTNKRAKPAVHFGGKFRIIDFALSNCINSGIRRMGVITQYQSHTLVQHIQRGWSFFNEEMNEFVDLLPAQQRMKGENWYRGTADAVTQNLDIIRRYKAEYVVILAGDHIYKQDYSRMLIDHVEKGARCTVACMPVPIEEASAFGVMAVDENDKIIEFVEKPANPPSMPNDPSKSLASMGIYVFDADYLYELLEEDDRDENSSHDFGKDLIPKITEAGLAYAHPFPLSCVQSDPDAEPYWRDVGTLEAYWKANLDLASVVPELDMYDRNWPIRTYNESLPPAKFVQDRSGSHGMTLNSLVSGGCVISGSVVVQSVLFSRVRVNSFCNIDSAVLLPEVWVGRSCRLRRCVIDRACVIPEGMVIGENAEEDARRFYRSEEGIVLVTREMLRKLGHKQER
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: SMC_THEVB
Sequence: MYIKRLELTNFKSFGGTTVIPLLPGFTVISGPNGSGKSNLLDALLFALGLAGSKGMRAERLPDLVNHSQTRRGHSVVETRVTVTFALDAETEWRVTRRLRVTKQGSYTSTYAVNDQPCTLNELHDQLQAFCIYPQGYNVVLQGDVTSMISMNAKARREIIDELAGVADFDRKIAQAREKLDTVKEREERFRIVERELIQQRDRLQRERLHAEKYQALRLELQEREQWLLVRQWQAHEEQKVQLQAQIQTLQQEQTQRQEQLQQKAQEMAAAAVTLEQLNRQVKALGEEEYLRLQATLADLHAQQRQCQRQQAANQQQQEQLAEQLQQGQAQYHRQQAQHRQLAEELAQQRGDRTPLMTAVANSQATLEALRQQVQELSTAAQTWFQEHSQRRQRIDALIHELEPSRTELSRLQERSQQLRQRQGELHQAATALEGQQLELQDALTTAAAAIKQQEQQLQTLAQQLATAQQQLSRTEETYQRLEREQRQKQRELDQLEARQQAVQETQGGFAARLILSADLPGVLGLVAQLGQVEPRYQLALEIAAGARLGNIVVADDSVAAAAIALLKREQAGRATFLPLNKMARPKPLSPIALAGCIDYALNLVTFEPQYAPIFAYVFGSTLVFESLEAAREYLGQYRMVTLEGELLEPSGAMTGGSQRRPNTLRFAQGVPPQESAEVQQVRDRLGELERLLDRLLQERTHQQGRVNALSQALSEAHQSHRDRQRQWEQLQQQQQQLNRQQAELERQQQYLSQELTAAETELTHLEARLPELEAELAAERLALNALEASPSHQQWQQVQAQLQAQEKIHASQVAALQAVDQALGDRHRQLEQLERDLKQTEQEIQRLCQAQREMRCQQQALDQTLGDLATQIERTQAALRELDSRLGHLKGDRDRHEYQLRQQQKNYQQLEWQYQKASETLTTLQAQLQELSTIEPPPLPQPLPEVPAELSLRDIQQQCQALEQRLRAMEPVNMLAIQEFEETQARLKELQEKLAVLAAERTEILLRIENFTTLRHQSFREAFDAINANFQTIFATLSDGDGYLQLESPEDPFAGGLNLVAHPKGKPVQRLASMSGGEKSLTALSFIFALQRYRPSPFYAFDEVDMFLDGANVERLAKMIQQQSQQAQFIVVSLRRPMIEAAQRTIGVTQARGQHTQVIGLDLTAYP
What is the function of this protein?
Required for chromosome condensation and partitioning.
What are the official names of this protein?
Chromosome partition protein Smc.
What is the protein family that this protein belongs to?
Belongs to the SMC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_THET8
Sequence: MHVVYPGSFDPLTNGHLDVIQRASRLFEKVTVAVLENPSKRGQYLFSAEERLAIIREATAHLANVEAATFSGLLVDFVRRVGAQAIVKGLRAVSDYEYELQMAHLNRQLYPGLETLFILAATRYSFVSSTMVKEIARYGGDVSKLVPPATLRALKAKLGQ
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_SHEB9
Sequence: MNLKQKWDVYSRLTRIDRPIGTLLLLWPCLMALMLAAGGMPDLKVLVIFIIGVVIMRACGCIINDYADRDLDSFVERTRSRPLASGEISTKEALILFVILGLSAFGLVLLLNGLVVKLSVVGIILTIIYPFTKRITNMPQMFLGIVWSWSIPMAYAAQTGEVPMEAWWLFAANWCWTVAYDTMYAMVDRDDDLKVGIKSTAILFGKYDRQIIGLFQLAALACFIAAGWSADRGLLYGLGILTFVGFSTYQQMLIFDRERAPCFKAFLNNNWAGLALFVGLGADYLI
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: APAH_PSEA7
Sequence: MTVYAVGDLQGCLEPLKCLLERVAFDPAKDRLWLVGDLVNRGPQSLETLRFLYAMREAVVSVLGNHDLHLLAVAHRSERLKKSDTLREILEAPDREALLDWLRRLPLLHYDEQRQVTLVHAGIPPQWSLEKARLRAAEVEEALRDDQRLPLFLEGMYGNEPAKWDKKLHGIERLRVITNYFTRMRFCTEDGRLDLKSKEGLDTAPPGYAPWFSFASRKTRGEKIIFGHWAALEGQCDEPGLFALDTGCVWGAKMTLLNVDSGERLSCDCAGQQASAKPAGPPA
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: NNRE_SCLS1
Sequence: MAAKYLSAANAAALDKDLMSMGAFSLDQLMELAGLSVSQVVYKVHPPSKGRRILVACGPGNNGGDGLVAARHLWHYGYKPTIYYPKPGKNELYQRLSTQLRNLSIPFTDDFPSAIKDSDHIVDAIFGFSFTGSIRSPFDTIISTLEATSLPITSIDAPSSWDITNGPPSSGPGANLMPQYLISLTAPKPLVRYFKGRHFLGGRFVTPEIHQKYNLQLPEYEGVDQIVEVPIEESEEKL
What is the function of this protein?
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
What are the official names of this protein?
NAD(P)H-hydrate epimerase, NAD(P)HX epimerase.
What is the protein family that this protein belongs to?
Belongs to the NnrE/AIBP family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion.
Protein: PPAC_STREM
Sequence: MSKLLVFGHQNPDTDAIASSYAFDYLAKKAFDLDTEVVALGDPNEETAFALDYFGVSAPRVVTSAKAEGASHVILTDHNEFPQSISDIREVEVYGIVDHHRVANFETANPLYMRVEPVGSASSIVYRLFKENRVDVPKDIAGLLLSGLISDTLLLKSPTTHASDHRVAVELAELAGVKLEEYGMAMLKAGTNLASKSEAELIDIDAKTFELNGNAVRVAQVNTVDIAEVLERKEAIEAAIKEVMASEGYSDFVLMITDIVNSNSEILALGANMDKVETAFDFKLEDNHAFLAGAVSRKKQVVPQLTESFGA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_RUMCH
Sequence: MKLFELQPAPGSKKLPNRKGRGIGSGNGKTGGRGHKGQNARAGGGVRPGFEGGQMPLYMRLPKRGFNNYEFSKKYTEVNVSDLNIFDEGTVVTEELLKSSGLAKKIIDGVAILGNGELTKKLTVQATKFTKTATEKIEAAGGKVEVV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: NR0B1_HUMAN
Sequence: MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRAGLPGGRPVALLYRCCFCGEDHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEARKVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQGPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI
What is the function of this protein?
Orphan nuclear receptor.  Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis.  Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions.  May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 0 group B member 1, DSS-AHC critical region on the X chromosome protein 1, Nuclear receptor DAX-1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR0 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus.
Protein: Y885_RICRS
Sequence: MSEVVIKEQLEQYISKIERLEQEKADLSQEVKDIFQDASSHGFDVKAMKSILKLKKLDKDKLAEQDAMLELYRDTLGI
What are the official names of this protein?
UPF0335 protein A1G_00885.
What is the protein family that this protein belongs to?
Belongs to the UPF0335 family.
Protein: PYRB_ANADE
Sequence: MIGRHKHCIALEDFSREEILEVIDLAVSMKEVLQRPIKKVPSLRGKMVVNLFFEASTRTRSSFETAAKILSADALNWTSSSSSVTKGETLVDTAKNLEAMRPDVLVIRHSAGGAPRLVAEHVGCSVVSAGDGAHEHPSQGLLDCFTLREKLGTLEGKTVAIVGDVSHSRVARSDLHAFPKLGAKVRLCGPPTMMPAGVERLGATVHTDLREAVDGADAVIMLRIQHERIGDPLIPGTREYSKVWGLNAKKAADWLKPSCVILHPGPINRGVELSPEVADGPRSVILDQVQNGVAVRMAILYLLAGGAGEEARA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RS13_ACIBC
Sequence: MARIAGVNIPDNKHAVISLTYIFGIGRHTAKNILAAVGITETTKIRELDDAQLDAIRAEVAKVPTEGDLRREISMNIKRLMDLGCYRGLRHRRSLPVRGQRTKTNARTRKGPRKPIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: HISX_RHOPA
Sequence: MPLRLDNASPDFASKFKAFLAMKREVAADIEAATRAIVDDVAHRGDAALLEATEKFDRLTLDAAGMRVGEAEVEAAVKACDSETVDALKLARDRIEFFHRRQLPKDDRFTDPLGVELGWRWSAIEAVGLYVPGGTAAYPSSVLMNAIPAKVAGVERVVMVVPSPGGTLNPLVLAAAQLAGATEIYRIGGAQAVAALAYGTATIAPVAKIVGPGNAYVAAAKRLVFGRVGIDMIAGPSEVVVVADKTANPDWIAADLLAQAEHDANAQSILITDSAVLAADVERALAAQLTTLPRVKIARASWDEFGAIIKVAKLEDAVPLANAIAAEHLEIMTADPEAFADKIRNAGAIFLGGHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLDFMKRTSILKCGPEQLAVLGPAAMALGKAEGLDAHARSVGLRLNQR
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: ATPFD_MYCVP
Sequence: MSIFIGQLIGFAVIVFILVKWVVPPIKGLMQKQQEAVRVALAESAEAGKKLADADAMHAKAVEDAKAAGAKVTEEAQQDSQRITAQLAEQADAEAERIKAQGAQQVQLMRQQLIRQLRSGLGSESVQKAEEIVRNYVSDPAAQASTVDRFLDELDAMAPSSAVLEAGASLNLRAASREALAELVKKFESVAESADTAALATLADNLSAVARLLLTSATLDKHLAEPTGDSAAKVRLLERLFGGKVDDNTMDLLKTAVAQRWSTEGNLIDAVEHVARLALLVRAEREGQSEEVEDQLFRFGRVLDAQSQLSRLLADPVIPADKRVALLKKVLDSGGGVNPIAEALLTQTVELIRGASADDAVNDLAELAVARRGEAVAQVTAAADLSDAQRTRLTEVLSRIYGTPVSIQLEVDPEVLGGLLITVGDEVIDGSISSRLAAARTGLPD
What is the function of this protein?
This fusion protein includes a component of the F(0) channel (subunit b) and of the F(1) subunit (subunit delta).  Two copies of subunit b and one of delta together form the peripheral 'stator' stalk which links F(1) to F(0) (By similarity).
What are the official names of this protein?
ATP synthase subunit b-delta.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: DCR1_CAEEL
Sequence: MVRVRADLQCFNPRDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLVEQQAIHIEVHTSFKVGQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIRHAYLKIEDMCVLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKVAPEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEIFDETVAFVNTTTEFHPDLDLDPRRPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKIIKSQVLPDKTLRFLNMAKTSMITIKRLLEPEMKKIKSIEALRPYVPQRVIRLFEILETFNPEFQKERMKLEKAEHLSAIIFVDQRYIAYSLLLMMRHIKSWEPKFKFVNPDYVVGASGRNLASSDSQGLHKRQTEVLRRFHRNEINCLIATSVLEEGVDVKQCNLVIKFDRPLDMRSYVQSKGRARRAGSRYVITVEEKDTAACDSDLKDFQQIEKILLSRHRTVNNPIEDDSDRFEEFDVDSQMEPYVVEKTGATLKMSTAIALINRYCSKLPSDIFTRLVPHNQIIPIEENGVTKYCAELLLPINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEHIDEEPDEYAPGIAAKVGSSKRKQLYDKKIARALNESFVEADKECFIYAFELERFREAELTLNPKRRKFEDPFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQMCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPKDEVRRQYKFNAEDYKDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKYKLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSSQRQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVKAFGKEKTKLDDNVEWNSLAYATEYEEKQTIIVKKIQQLRDLNQKSIEDQERETRENDKIDDGEELFNIGVWDPEEAVRIGVEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDDELPFVMHDYTARLTSNRNGIGAWSGSESIVPSGWGDWDGPEPDNSPMPFQILGGPGGLNVQALMADVGRVFDPSTASSSLSQTVQESTVSPPKQLTKEEEQFKKLQNDLLKQAKERLEALEMSEDMEKPRRLEDTVNLEDYGDDQENQEDENTPTNFPKTIDEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLPVAINEKSRSFSFEKESKAINGRLIRQRSEEYVSHIDSDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATTDYLYHTLLDQHEGKLSFARSKEVSNCNLYRLGKKLGIPQLIVANKFDAHDSWLPPCYIPTCDFKAPNTDDAEEKDNEIERILDGQVIEEKPENKTGWDIGGDVSKSTTDGIETITFPKQARVGNDDISPLPYNLLTQQHISDKSIADAVEALIGVHLLTLGPNPTLKVMNWMGLKVIQKDQKSDVPSPLLRFIDTPTNPNASLNFLNNLWQQFQFTQLEEKIGYRFKERAYLVQAFTHASYINNRVTGCYQRLEFLGDAVLDYMITRYLFEDSRQYSPGVLTDLRSALVNNTIFASLAVKFEFQKHFIAMCPGLYHMIEKFVKLCSERNFDTNFNAEMYMVTTEEEIDEGQEEDIEVPKAMGDIFESVAGAIYLDSGRNLDTTWQVIFHMMRGTIELCCANPPRSPIRELMEFEQSKVRFSKMERILESGKVRVTVEVVNNMRFTGMGRNYRIAKATAAKRALKYLHQIEQQRRQSPSLTTV
What is the function of this protein?
tDCR-1 acts as a deoxyribonuclease (DNase) initiating DNA fragmentation during apoptosis, upstream of nucleases cps-6, crn-2 and nuc-1.
What are the official names of this protein?
Endoribonuclease dcr-1.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Dicer subfamily.
Protein: REV7_SCHPO
Sequence: MENDTGWSVKKCIDIFGEFLLVSIHCILYARRLYPQDLFIKARKYNTIVWQSRHPILCEYIEEVVQSCIEELQTGSVHQVALSIINKEQREEERYVFSTDSIPIIPDFLLEKQISTNEPFTDAYVEYMRASLIQLLNITNGLPLIEQECTWTLRVTLKDGFPRPKQWEEWFLPPQARETDATRQFKGITIPVRNVDIGPMMTEIWVEKYTNSD
What is the function of this protein?
Required for DNA damage induced mutagenesis.  Involved in DNA repair, mitochondrial DNA repair and translesion synthesis.  Has a role in the bypass of abasic (AP) sites (By similarity).
What are the official names of this protein?
DNA polymerase zeta processivity subunit, Revertibility protein 7.
What is the protein family that this protein belongs to?
Belongs to the MAD2 family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus.
Protein: INS_HORSE
Sequence: FVNQHLCGSHLVEALYLVCGERGFFYTPKAXXEAEDPQVGEVELGGGPGLGGLQPLALAGPQQXXGIVEQCCTGICSLYQLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PB1F2_I56A2
Sequence: MEQEQDTPWTQSTGHINIQKKGNGQQTRKPERPNSTQLMDHYLRTMSQVDMHRQTASWKPWPSLKNPTQESLKTRVLKRWKLFNKQGWTS
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: ATPL2_PELPD
Sequence: MSFFSMCVLGAAIGMAIGTLGTGIGQGLAVKSAVEGVSRNPGASGKIMTTMMIGLAMIESLAIYALVICLIILFANPYKDIALKLAETVAK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c 2, ATP synthase F(0) sector subunit c 2, F-type ATPase subunit c 2, F-ATPase subunit c 2, Lipid-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GCS2_HALWD
Sequence: MDVGSADAFDRMGTLGVEEEFFVVDDSGQPTAGIQELIYDYNHPPAGVLADRLDHELFQFVIETQTPLLEDVSAVSESVQAVRDALVTHAADHGYRIAAAGLHPTAKWRERNHVEKPRYQSQLDRIQYPQHRNTTAGLHVHVGVDDPDAATWIANELRWYLPPLLALSANSPYWNGFDTGLASARAKIFEALPNTGMPTRFEDFEAYYQLEKRMVETGSIKDRGELWYDVRPHTGHGTVEVRTPDAQADPSVTVAIVEYIHALVMDFAARYADGESGTKVRREILDANKWHAMRYGRDAEFIIPGSMETVTLSEFVDRETNRLGVDGLTTLLAREGGAKKQRRLHASDNIDTLLESLCLDTDT
What is the function of this protein?
Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-glutamylcysteine synthetase, GCS, Gamma-GCS.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: ATR_CUPMC
Sequence: MGNRLSKIATRTGDAGTTGLGDGSRVGKNSLRIVAIGDVDELNSHIGLLLTEPDLPEDVRAALLHIQHDLFDLGGELSIPGYTLLKAPQVAQLDDWLAHYNAALPRLAEFILPGGSRPAAQAHICRTVCRRAERALVELGAAEALNEAPRQYLNRLSDLLFVLARVLNRAGGGSDVLWQRERES
What is the function of this protein?
Adenosyltransferase that catalyzes the conversion of cob(II)alamin to adenosylcob(III)alamin (AdoCbl) in the presence of ATP and an electron donor.  Acts as an accessory protein of IcmF that functions in cofactor repair, since IcmF is prone to inactivation during catalytic turnover due to the occasional loss of the 5'-deoxyadenosine moiety and formation of the inactive cob(II)alamin cofactor in its active site.  Thus, receives and repairs the inactive cofactor, which is then reloaded onto IcmF in a GTPase-gated step.
What are the official names of this protein?
Cobalamin adenosyltransferase, ATR.
What is the protein family that this protein belongs to?
Belongs to the Cob(I)alamin adenosyltransferase family.
Protein: P2C25_ARATH
Sequence: MSCSVAVCNSPVFSPSSSLFCNKSSILSSPQESLSLTLSHRKPQTSSPSSPSTTVSSPKSPFRLRFQKPPSGFAPGPLSFGSESVSASSPPGGVLKRKRPTRLDIPIGVAGFVAPISSSAAVAATPREECREVEREGDGYSVYCKRGRREAMEDRFSAITNLHGDRKQAIFGVYDGHGGVKAAEFAAKNLDKNIVEEVVGKRDESEIAEAVKHGYLATDASFLKEEDVKGGSCCVTALVNEGNLVVSNAGDCRAVMSVGGVAKALSSDHRPSRDDERKRIETTGGYVDTFHGVWRIQGSLAVSRGIGDAQLKKWVIAEPETKISRIEHDHEFLILASDGLWDKVSNQEAVDIARPLCLGTEKPLLLAACKKLVDLSASRGSSDDISVMLIPLRQFI
What is the function of this protein?
Protein phosphatase that negatively regulates defense respones.  Inactivates MPK4 and MPK6 MAP kinases involved in stress and defense signaling.
What are the official names of this protein?
Probable protein phosphatase 2C 25, AtPP2C25, Protein phosphatase AP2C1.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ALDH_DEIRA
Sequence: MTVAEQQPQHQGYANPGTPGSVVTFKKRYDNFIGGQWVPPVKGQYFDNASPVDGKVFTQAARSTAEDVELALDAAHRAAPAWGRTSVTERSNILLKIADRMEQNLEMLAVAETWDNGKPVRETLAADLPLAIDHFRYFAGCIRAQEGGLSQIDDSTVAYHFHEPLGVVGQIIPWNFPLLMGVWKLAPALAAGNAVVLKPAEQTPASIMVLMELIADLLPEGVVNVVNGFGLEAGKPLASSPRIAKIAFTGETNTGRLIMGYAADNLIPVTLELGGKSPNIFFDDVMMEDDAFLDKAVEGMVMFALNQGEVCTCPSRALIQESIYDRFMERAVQRVEAITMGHPLDPGTMIGAQASTEQLDKILSYLDIGRAEGAEVLTGGERGQREGLEEGFYVKPTIFKGHNKMRIFQEEIFGPVLAAATFKDEAEALELANDTLYGLGAGLWTRDISRAYRMGRGIQAGRVWTNCYHVYPAHAAFGGYKQSGIGRENHRMMLDHYQQTKNLLVSYSPNKMGFF
What are the official names of this protein?
Aldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: RUVA_DICNV
Sequence: MIGWLQGRVLYKQNDQLLINVCGVGYELTVPQSVMASAQVGEELTVFVHHVQREDGQFLYGFSSFLQRQLFRELIRVSGIGPKLSIVILSGLTPEALIAAVRAQESAPFLRLSGIGKKTAERLLIELHDRVEKNDLFLCDESESSRAPIALSASEEAIQALIALELAPAEAELWVKKAQKTLAEDADSAALIKTAFALRLQGAK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: KAD1_NOSS1
Sequence: MTRLIFLGPPGAGKGTQAQILAEHLHIPHISTGDILRQAMKEQTPLGIKAQSYVDSGELVPDQLVQDLVEERLEQADAKSGWILDGFPRKVTQAAFLEELLQKTGQGGERVVNLDAADDVVVARLLSRGRKDDTEEVIRRRLEIYRSDTAPLIDYYSDRQKLLTINGDQSQEEVTHELKATLGS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase 1, AK 1, ATP-AMP transphosphorylase 1, ATP:AMP phosphotransferase 1, Adenylate monophosphate kinase 1.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_BACMK
Sequence: MYAIIETGGKQIKVEAGQAIYIEKLDVEAGETVTFDKVLFVGGENVKVGSPVVEGATVTAKVEKQGRAKKIIVFKYKAKKNNRKKQGHRQPYTKLVVEAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: LEU1_ECO24
Sequence: MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.