PharMolix/UniProtQA huggingface dataset:
Protein: VE7_HPV49
Sequence: MIGKEVTIPDIILQEEFGQPIDLQCYENLTAEAPAEQELEAEEELIQGIPYKVIATCGGGCGARLRVFVLATDAAIRSFQELLLEELQFLCPQCREEIRNGGR
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: Y1560_SHESM
Sequence: MGQYKIWVDADACPNPIKEILFRAAERKSLPLVLVANQMLRVPPSPYISQVRVGSGFDVADQYIVDHVEATHLVITADIPLAAQVIEKGALALNPRGELYTTDNIRQKLTMRDFMEDLRSSGVHTGGPDALSAADKQAFANSLDKWLVRV
What are the official names of this protein?
UPF0178 protein Shewmr4_1560.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: CSRA_CLOBA
Sequence: MLIITRKKDESLMIGDNIEITVLKLEDGSVKLGINAPRETTILRKELYEAVKQENKKAMNIDMNLLKGLKK
What is the function of this protein?
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation.  Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
What are the official names of this protein?
Translational regulator CsrA.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_STRM5
Sequence: MDVLLANPRGFCAGVDRAIEIVKRAIETLGAPIYVRHEVVHNRFVVDDLKQRGAIFVEELDEVPDNNTVIFSAHGVSQAVRQEAERRGLKVFDATCPLVTKVHFEVARHCRAGRDVVLIGHAGHPEVEGTMGQWNREAGTGQIYLVEDVEQVATLQIKQPENFAYTTQTTLSVDDTRGIIDALRERFPAMQGPKNDDICYATQNRQDAVRDLAKRCDLVLVVGSPNSSNSNRLSELARREGVESYLIDGAHEIDPAWVVGKQHIGVTAGASAPQVLVDGVLARLAELGANGVGELDGEPESMVFALPKELRLRLVD
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: SECG_STAAC
Sequence: MHTFLIVLLIIDCIALITVVLLQEGKSSGLSGAISGGAEQLFGKQKQRGVDLFLNRLTIILSILFFVLMICISYLGM
What is the function of this protein?
Involved in protein export.  Participates in an early event of protein translocation (By similarity).
What are the official names of this protein?
Probable protein-export membrane protein SecG.
What is the protein family that this protein belongs to?
Belongs to the SecG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2070_DICDI
Sequence: MTTTISSNLPSQLEISPTKLLITKQPIKLRESTESPFKSMMDTFKNTIISTSPTECEESSSSTITTPSEESLSSGEESSSISDSESKIITIATLLKPSNSVQDFTPLCNGAQETEIVKISNSINLSNFIIKHLVGKGGFGKVFQVVHVDTQKVYALKVIKKNHIIAKKSVVNTLAEKDILKKISHPFIVNLHYAFQNEKKLYLVMDFVNGGQLFYHLQKEAIFSEDQVRFYMAELILALEHLHDSNIVHRDLKPENILLDSQGHCILTDFGLAKLEVKTNNETFSFAGTLEYMAPEMIQHATCGKAVDWWSIGILMYDMMIGKPPFEHKNRALMQEKIISEKAKFPKFVSSSARSLINGLLTKDPTKRLGANGAIEIKRHPFFKSIQWRKIENKEITPPFVPSTKGIDDISNFDHASLKAHQRDSFSTSPTLSSSQQAYFDGFSFVRTPVLLESQK
What are the official names of this protein?
Probable serine/threonine-protein kinase DDB_G0277449.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Protein: EFTU_BACSU
Sequence: MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGTAMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLSEYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVEDVFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDNIGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFYFRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVSTITE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu, P-40.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_CLOPE
Sequence: MSNNIGKVVQVIGPVVDIKFANDELPNIFNAIHIKMDDGKILVCEVEQHVGDDIVRTIAMEATEGLRRGVEAVDTGAPISVPVGECVLGRIFNVLGKPLDSGAEVNNEEKYPIHRPAPSFEEQSVVPQMFETGIKVIDLLAPYQRGGKIGLFGGAGVGKTVLIQELINNIAKEHGGLSVFTGVGERSREGNDLYYEMMESGVIKNTALVFGQMNEPPGARMRVALTGLTMAEYFRDQGQDVLLFIDNIFRFSQAGSEVSALLGRIPSAVGYQPTLATEMGALQERITSTTHGSITSVQAVYVPADDLTDPAPATTFNHLDAKTVLSRSIAEIGIYPAVDPLDSSSRILDPRVVGEEHYEVASKVKHILERYKELQDIIAILGVDELADEDKLIVARARRIQKFLSQPFTVAEQFTGMQGRYVPIKETIRGFKEILEGKHDNVPESAFLFAGTIEEVLEKARAMAQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: P20D1_XENTR
Sequence: MAVSRWKAVGSTLLAAFLVGLVVLIAVLLIRTYTLPTAVRKWNRNESLITELAEKERKQLVEALKGAIRIPTVSFSEEEQNTTALREFGEYIQKVFPQVFSSSLIQHEVLGGYSHLFKVQGSDHNLLPYMLLAHIDVVPAPPESWEVPPFSGEERDGYIYGRGTLDDKNCVIGILQSLEFLLKRGHKPRRSFYIGLGHDEEISGHKGAQKIVEKLQSQGVKLAFVLDEGLAVLDGVIQGISQPVALVGTTEKGSVTLDLTVNRLPGHSSMPPSETSIGILAAAVSRLEQNMMPNMFGNGPEQDMFEHLSTKFDFPLNIIMANLWLFSPILSRILELSPSTNAIVRTTTALTIFKAGIKSNVIPPTATATVNFRLHPAQTVQEVLDIVQNTIKDERVELSVLNSFDPLPVSPNDMSLGYHILQRTIHDVFSGPPVAPGVCVGNTDSRHFVNLTNSIYRFSPVVLKKEDVDRIHGLNERISKEAIELLVQFYIQLIQNSDTDNIPPPHLDTHEL
What is the function of this protein?
Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase.  It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction.  Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner.  Thereby, this secreted protein may indirectly regulate whole body energy expenditure.  PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles.
What are the official names of this protein?
N-fatty-acyl-amino acid synthase/hydrolase PM20D1, Peptidase M20 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
What are the subcellular locations of this protein?
Secreted.
Protein: IXTPA_PROMA
Sequence: MSFNLGKSLTKLIIASNNDGKIEEFIQLLSGIPLVVMGQPKHLEVEETGVSFAENARIKAIAVAKATGEMALADDSGLSVGSLGGAPGVFSARYANTDLERVSRLLKELEMVDDRSAFFSAALCLASSKGEVLLELDGRCDGIITTTPRGKFGFGYDPIFEVKGTGLTFSEMDSKQKRELSHRGLAVKKLIPSLKKILDS
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: TAOK2_MOUSE
Sequence: MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEELTPCSQEAEPYTHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEEEGPESREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEMTPGPLQPPAAPPTSTSSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQLPMGLPATGALGPLSTGTPSEEQPCSSGQEAILDQRMLGEEEEAVPERRILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLANEEDWDISEEMKEIRVPSLASQERNIIGQEEAAAWSLWEKEGGNLVDVEFKLGWVQGPVLTPVPEEEEEEEEEGGAPIGTHRDPGDGCPSPDIPPEPPPSHLRQYPTSQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLFLCTALHLPPGLFLLLAQGTALLAVLSLSWRRGLMGVPLGLGAAWLLAWPSLALPLAAMAAGGKWVRQQGPQMRRGISRLWLRILLRLSPMVFRALQGCGAVGDRGLFALYPKTNKNGFRSRLPVPWPRQGNPRTTQHPLAQLTRVWAVCKGWNWRLARASHRLASCLPPWAVHILASWGLLKGERPSRIPRLLPRSQRRLGLSASRQLPPGTVAGRRSQTRRTLPPWR
What is the function of this protein?
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade.  Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins.  Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases.  In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases.  May affect microtubule organization and stability.  May play a role in the osmotic stress-MAPK8 pathway.  Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation.  Isoform 2, but not isoform 1, is required for PCDH8 endocytosis.  Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2.  This process leads to PCDH8 endocytosis and CDH2 cointernalization.  Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase TAO2, Thousand and one amino acid protein 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Note=Found to be perinuclear and localized to vesicular compartment. SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8.
Protein: FTR_METKA
Sequence: MEINGVEIEDTFAEAFEAKMARVLITAASHKWAMIAVKEATGFGTSVIMCPAEAGIDCGYVPPEETPDGRPGVTIMIGHNDEDELKEQLLDRIGQCVMTAPTASAFDAMPEAEKEDEDRVGYKLSFFGDGYQEEDELDGRKVWKIPVVEGEFIVEDSFGITTGVAGGNFYIMAESQPAGLQAAEAAVDAIKGVEGAYAPFPGGIVASASKVGSKQYDFLPASTNDAYCPTVEDNELPEGVKCVYEIVINGLNEEAVKEAMRVGIEAACQQPGVVKISAGNFGGKLGQYEIHLHDLF
What is the function of this protein?
Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR) (By similarity) (PubMed:11054114, PubMed:1483480, PubMed:7601152).  Acts via a ternary-complex mechanism.  Uses N-furfurylformamide much less efficiently, does not use N-methylformamide or formamide (PubMed:1483480, PubMed:11054114, PubMed:7601152).  Protein overexpressed in E. coli has very similar properties to enzyme purified from M. kandleri (PubMed:7601152).
What are the official names of this protein?
Formylmethanofuran--tetrahydromethanopterin formyltransferase, Ftr, H4MPT formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the FTR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_ECOLC
Sequence: MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: AROB_STRP4
Sequence: MKIRIDIPHHPYDIQIEKGCMAQAGQWLRELWQPQKVVIVTDNHVASLYAEKVKLSLEDAGFQVAVFDFLEGEERKNLTTVQKVYEFLVKQGLTRSDGIVALGGGVVGDLAGFVASTYMRGIHFVQIPTSLTAQVDSSIGGKTGVNTPFAKNMVGTFAQPDGVLIDPLVLETLGKRELIEGMGEVIKYGLIEDPELWALLTGLNGSVESILEHAETLIXHSCQVKRKMVVEDELDNGIRLYLNFGHTIGHAIEATAGYGKVMHGEAVAMGMVQISKIAEEKGLMPAGITQSITEMCQKFGLPVDYENWEVDKLYQALTHDKKARGNTLKLVLVPELGSATIHPVSLEEMKDYLVK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_MICMR
Sequence: MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLITQILTGLFLAMHYTSDTATAFSSVAHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGVYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPTGLNSDSDKIPFHPYYTIKDFLGVLILLMAFMILTLFFPDILGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALMPLLHTSKQRALTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQTASIAYFAIIVILMPIAGMIENNILDLD
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: G3P_CUTCU
Sequence: MATKVGINGFGRIGRIVLRNALEHGDIDVVAINDPFIDLDYMVYMFKYDSTHGRFKGKVETKDGKLVIEGKPISVFGERDPAAIPWGKAGADYVVESTGVFTTIEKASLHLKGGAKKVIISAPSADAPMFVCGVNLEAYKPEYEVISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHATTATQKTVDGPSHKDWRGGRGAAANIIPSSTGAAKAVGKVIPSLNGKLTGMSFRIPTSDVSVVDLVVRLEKGASYDQIKEVIKKASEGELKGILGYTEDEVVSTDFLGSTESSVFDAKAGIPLNDKFVKLISWYDNEYGYSRRVCDLIAYVAKKDKSA
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GBRB2_MOUSE
Sequence: MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAANANNEKMRLDVNKMFYKDIKQNGTQYRSLWDPTGDLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:20400944).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275).  The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:27129275).  Functions also as histamine receptor and mediates cellular responses to histamine (By similarity).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit beta-2, GABA(A) receptor subunit beta-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
Protein: MNTP_SALHS
Sequence: MHYTATVLLAFGMSMDAFAASIGKGATLHKPKFSEALRTGLIFGAVETLTPLIGWGLGILASKFVLEWNHWIAFVLLIFLGGRMIIEGIRGGSDEDETPLRRHSFWLLVTTAIATSLDAMAVGVGLAFLQVNIIATALAIGCATLIMSTLGMMIGRFIGPMLGKRAEILGGVVLIGIGVQILWTHFHG
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Probable manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUA_STRE4
Sequence: MTRYKAIISYDGTLFSGFQRQSQARTVQEEIEKTLQKLTGGQGIQIHGAGRTDAGVHAYGQVIHFDLEQKRDPEKLRFALDTQTPDDIDVISLEIAADDFHARYHKHFKTYEFLVDIGRPKNPMMRHYATHYPYPLDIAKMQAAIKDLVGTHDFTGFTAAGTSVKNKVRTITAATLTQDPKTGFLVFTFSGNGFLYKQVRNMVGTLLKIGNGRLPIEQIRLVLESKNRQLAGPTAAGNGLYLKEIIYEE
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: ARSB_MOUSE
Sequence: MGKLSPCTGRSRPGGPGPQLPLLLLLLQLLLLLLSPARASGATQPPHVVFVLADDLGWNDLGFHGSVIRTPHLDALAAGGVVLDNYYVQPLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSCVPLDEKLLPQLLKEAGYATHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIESLNGTRCALDLRDGEEPAKEYNNIYSTNIFTKRATTVIANHPPEKPLFLYLAFQSVHDPLQVPEEYMEPYGFIQDKHRRIYAGMVSLMDEAVGNVTKALKSHGLWNNTVFIFSTDNGGQTRSGGNNWPLRGRKGTLWEGGIRGTGFVASPLLKQKGVKSRELMHITDWLPTLVDLAGGSTNGTKPLDGFNMWKTISEGHPSPRVELLHNIDQDFFDGLPCPGKNMTPAKDDSFPLEHSAFNTSIHAGIRYKNWKLLTGHPGCGYWFPPPSQSNVSEIPPVGPPTKTLWLFDINQDPEERHDVSREHPHIVQNLLSRLQYYHEHSVPSHFPPLDPRCDPKSTGVWSPWM
What is the function of this protein?
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity).  Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity).  In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
What are the official names of this protein?
Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Lysosome. Cell surface.
Protein: CPHB_THEVB
Sequence: MLYRIPVSTVGYWHSPWQIHQFLLPIERFIHRNPMLQLDPISKTTHQHSGHKGLVMAIGGAEDKVRGRQILTTFCQRAGGLDAVIGVIPSASREPDAMGRLYHDIFRDIGVREVDILLVGDRADAEQEEMLARLSRCTGIFMSGGDQLRLSALLDETPLLYQLRHQVWEGKSILGGTSAGAAVLGECMIASGGSNEAPNRSLVDLATGLGILPDVLVDQHFHNRNRLARLISAISAHPDKLGVGIDEDTCAMFEADGTLRVLGRGSVTIVDPRDVSYTNYAHVDVNEPLSIYNLRLHILSDGDCYNLRTHQVQHKCILPPLN
What is the function of this protein?
Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.
What are the official names of this protein?
Cyanophycinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
Protein: WCSD_DROME
Sequence: MALQGWRFFGVSATIIIYIGGVLFLSMNNIPGSHPKRPRIERFAEFPSFHSPRFPMPSRKMTIRWCRDLKYINRDLPIYADYKSDFYTALPSDVSAALQSLPALTALASFPGSGNTWLRYLLQQATGILTGSIYKDYGLLKTGFPAENVCNSSVLLVKTHEWGSKAWAPFSKAILLVRDPEKAIIAEFNRQSGGHIGFASPDRYKRTKGKYWQQFVSNKLKGWEMMNLSWARNFTGSIKVVFYDDLVHHTERELRSILDFLQFPINEQLMRCAIMRKEGIFRRKKRLLSFDPYTESMRAEVQNRRRIVYGLLGRQEP
What are the official names of this protein?
WSCD family member CG9164.
What is the protein family that this protein belongs to?
Belongs to the WSCD family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: VE4_HPV51
Sequence: MDCEVPAATRYPLLQLLNNYQTPQRPIPLPPAWAPKKPRHNSENDSDLLSPTPPQSPHCPWTIQTTKYTVEVEALTLEGTKVQLRLRL
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: Y033_BRUO2
Sequence: MRDMMGMMKQAKELQAKMKAMQDEIATMEASASSGGGLVTVTLSGKGTLSALKIDPSLMKEDEVEILEDLIIAAHNDAKAKLEAAMAEKTQSLTAGLPIPPGFKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein BOV_0033.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.