PharMolix/UniProtQA huggingface dataset:
Protein: LIPA_HALLT
Sequence: MQRGRRKPDWLKSRPPSGSRFTEIKERLRERDLHTVCEEANCPNMGECWSGRDGPGTATFMLMGDRCSRGCNFCDVETGGMKSLDSDEPENVADAVAEIGLDYVVLTSVDRDDLADGGSEHFAETIREIQRRDPEILVETLIPDFQGDPEAIDRIIDAGPDVIAHNVETVERLQWPVRDRRADYEQSLAVLDRVGRESDIHTKTSLMLGVGEYDHEVYRTLGDLSEVGVDVVTFGQYLQPSRSHLDVFEYVHPDVFETWRAVAEREFDFLYCASGPMVRSSYKAGELFVEALLREGRSPEDARRHARAAGGD
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMUV_ROSDO
Sequence: MSLDAADITVKLGRTPILHGIGFCAKPGEVSAIVGPNGSGKTTLLRAITGDLPFDGTVRLNGKDTSRMKPWELSAIRAVLPQSAVLAFPFTVAEVVRLGVQAGVCARDCDAPMAALSQVRLAHYADRFYHELSGGEQQRVQLARVLAQVWRPVVGGAPRWLLLDEPVASLDIANQLEVMEITRAYASAGGGVVAVMHDLNLTAMFADHLAILSGGQCLAAGPPEQVMTDAILSQAYGCALRVNTPPPHSATYVLPHAANRL
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DPO3_STRS2
Sequence: MSDKFQLLLQQIGMPLDARQSGAFSTATIEKVVLHKVSKLWEFTFRFETPLPLMDYQLFKARLATEFEKVGNKIQFSIVSDAEAFEAGLVEAYYPEAFTEDLCQSAGFKALFQPLEVAYRDGVLWIKGPETIDTDHFRKNHLPNLVEQYKRFGFGNLAVDIQVCQEMTQQQAEIFHAQNAEIYQQANEENLAALEQLAQMAPPPEAAQPFVPEYKKNRPAKVNIEKAEITPMIEVDSEENRIVFEGLVFEVEQKTTKTGRVIINFKMTDYTSSFTLQKWAKNEEEAQKFDMVKKGNWLRVRGNVETNNFTRDLTMNVQEVQEVKKEIRKDLMPEGEKRVEFHAHTNMSTMDALPAVEDLVARAAAWGHKAVAITDHGNVQSFPHGYHAARKAGIKPLFGMEANIVEDSVPIAYNEADVVLSDATYVVFDVETTGLSAVNNALIQIAASKMHKGNIIAEFDEFIDPGHPLSQFTTDLTGITDEHVRGSKPLEQVLREFQDFCQDSVMVAHNATFDVGFMNVNYERAGLPIISQPVIDTLEFARNLYPDFKRHGLGPLTKRFGVALEHHHMANYDAEATGRLLFIFLKDALEKHNLTNLNQLNTELIAEDSYKKARVKHATLYVINQVGLKNMFKLVSLSNTKYFEGVPRIPRTVLNAHREGLILGTACQEGEVFDDLLSKGIDEAVKTAAYYDFIEVMPPALYAPMIAKEQFKDMAEIEETIKQLIEVGRRAGLPVLATGNVHYIDPEEEIYREIIVRALGQGAPINWTIGNGENAQPAPLPKAHFRTTSEMLDEFAFLGESLAREIVITNPNAMLDRFEDVQVVKTDLYTPYIEKAEETVAELTYQKAFEIYGNPLPDIIDLRIEKELTSILGNGFAVIYLASQMLVHRSNERGYLVGSRGSVGSSFVATMIGITEVNPMPPHYVCPNCQHSEFITDGSYGSGFDLPDKDCEKCGTKYKKDGQDIPFETFLGFDGDKVPDIDLNFSGDDQPSAHLDVRDIFGEENAFRAGTVGTVAAKTAYGFVRGYERDYGKFYRDVEVERLAAGAAGVKRTTGQHPGGIIVFPDYMDVYDFTPVQYPADDVTASWQTTHFNFHDIDENVLKLDILGHDDPTMVRKLQDLSGIDPQTIPADDKGVMALFSGTEILGVTPEQIGTPTGMLGIPEFGTNFVRGMVEETKPTTFSELLQLSGLSHGTDVWLGNAQDLIKAGIANLSTVIGCRDDIMVYLMHAGLPPKMAFNIMERVRKGLWLKISEEERNGYIQAMKDNKVPDWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPLYYYCAYFSIRAKAFDLATMSGGLERVKAKMEEIALKKKNNEASNVEQDLYTTLELVNEMLERGFKFGKLDLYKSHATDFLIEEDTLIPPFVAMDGLGENVAKQVVAARAEGEFLSKTELRKRGGLSGTLVEKMDEMGILGKMPEDNQLSLFDDLF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL136_HCMVM
Sequence: MSVKGVEMPEMTWDLDVGNKWRRRKVLSRIHRFWECRLRVWWLSDAGVRETDPPRPRRRPTWMTAVFHVICAVLLTLMIMAIGALIAYLRYYHQDSWRDMLHDLFCGCHYPEKCRRHHERQRSRRRAMDVPDPELGDPARRPLNGAMYYGSGCRFDTVEMVDETRPAPPALSSPETGDDSNDDAVAGGGAGGVTSSATRTTSSNALLPEWMDAVHVAVQAAVQATVQVSGPRENAVSPAT
What are the official names of this protein?
Protein UL136.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL136 protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: CRCB_SHEPC
Sequence: MTNVLLVALGGSIGAVFRYLISIFMIQVFGSSFPFGTLVVNVIGSFFMGVIYALGQMSHISPELKALIGVGLLGALTTFSTFSNETLLLLQEGDWLKAILNVVLNLSLCLFMVYLGQQLVFSRI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIMKB_BOVIN
Sequence: MCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDELVLTVEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDSDITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPQANTAVDNMSASSSSVDSDPETTERELLTKLPGGLFNMNQLLANEIKLLVE
What is the function of this protein?
Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate.  Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.
What are the official names of this protein?
Beta-citrylglutamate synthase B, N-acetyl-aspartylglutamate synthetase B, NAAG synthetase B, NAAGS, Ribosomal protein S6 modification-like protein B.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T2R13_PAPHA
Sequence: MESALLSILTLVIIAEFVIGNLSNGFXVLINCIDWVSKRQLSSVDKILTFLAISRIGLIWELLVSWFLGLHYLAIFVSGTGLRIMIFSWVVSNHFSLWLATILSIFYLLKIASFSSPAFLYLKWRVNQVILMILLGTLVFLFLNLIQINIHIKDWLDRCERNTIWNFSMSGLPTFSVPVKFTMTMFSLAPFTVALISFLLLIFSLRKHLQKMQLNYKGHREPRTKAHINALKIVISFLLLYASFFLCILISWISELYQNTLIHMFCQTIGVFYPSSHSFLLILGNPKLRQASLLVAAKVWAKR
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 13, T2R13.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y1597_ARCFU
Sequence: MGEDAVRLGELALKLERYRYNVALATTWAIFGMVFGSMITLASSLMLLGLGYEVHWHY
What are the official names of this protein?
Uncharacterized protein AF_1597.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TRI11_BOVIN
Sequence: MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELFPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCAAHREPLAAFCGDELRLLCAACERSGEHWAHRVRPLQDAAEDLKSKLEKSLEHLRKQMEDALLFQAQAEETCSLWQKMVETQRQNVLTEFERLRRLLVEEEQLLLQRLEEEELEVLPPLRESAARLGQQSAQLAELITELEGRCQLPALGLLQDIRDTLRRVQDVKLQPPEVVPMEMRTVCRVPGLVEALRRFRGDMTLDPDTANPELVLSEDRRSVRRGDLRQALPDSPERFDPGPCVLGREPLTSGRHYWEVEVGERASWALGVCRENANRKEKGELFAGNGFWILVFLGSYYNSSERAFAPLRDPPRRVGIFLDYEAGHLSFYSANDGSLLYTFPETPFSGTLRALFSPLSSSPTPMTICRLKGGPGDGLAPQ
What is the function of this protein?
E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX.  Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis.  May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences.  May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity).  Mediates MED15 ubiquitination leading to proteasomal degradation.  May contribute to the innate restriction of retroviruses.  Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression.  Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain.  May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.  Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2.  Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM11, Tripartite motif-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In the nucleus, colocalizes with PAX6.
Protein: REP1_LACFM
Sequence: MGALYNEDYDATDMTETRLLAIPLQAYVYRTFSNVMRSASEHLDDKYAQEAHEESETIRAHWEALETRYEVPDWSKEDFDVSEGITNVDTAVRLAESAERFVRQTNLELSANQLLRLLHYRSMQERQWELETRSYLNDLINLVEDPADQKRIDDVLMPWFANKPFMVELTTEELTQLRKKIEDAIKNTNVQKSARQALKKYPLLSTFSSNGSRRGRSNKHRVVH
What is the function of this protein?
Plasmid partition require REP1, REP2, and a cis-acting DNA sequence (known as STB).  REP1 may act by intercalating in the yeast nuclear matrix and binding STB either directly or via REP2.
What are the official names of this protein?
Trans-acting factor B, REP1.
Protein: ATPE_PELTS
Sequence: MSDKTQRLEIVTPQRKVFSEDVSFLVAPGTEGELGVLPNHAPLITSLNIGIMRIQQEGKTFKVVVTGGFMEVRDNKVTVLANAAERAEEIDVARAEAARRRAEERLAKKTPDIDVLRAELALKRALTRLKAAGQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CALM_AJECG
Sequence: MADSLTEEQVSEYKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin, CaM.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: RNFA_VIBA3
Sequence: MTEYLLLLVGTVLVNNFVLVKFLGLCPFMGVSKKLETAIGMGLATTFVLTLASVSAYLVETYILTPLGIEYLRTMSFILVIAVVVQFTEMVVHKTSPTLYRLLGIFLPLITTNCAVLGVALLNINENHNFIQSIIYGFGAAVGFSLVLILFAAMRERIAVADVPMPFKGASIAMITAGLMSLAFMGFTGLVK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rnf electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROB_CHLCV
Sequence: MIENFISDPHNVKFVENFFNSELFSSLSTDYPIVMISDHYVAEELLPPILDFMDNLGYRVILLTFPPGEKNKTWETFISLQNQLIDQGVSLGSTIIGIGGGIILDMAGFLASTYCRGVPLFLIPTTLTAMIDASIGGKNGINLRGFKNRLGTFYPPKDVWICPEFLATLPKKEWLHGIPEAIKHGCIADAYIWEFLDNCRDRLFSSQEILHEFIKRNCMVKAAIVAKDPKDQNLRKTLNFGHTIAHAIETLSKGHISHGLAVSVGMMIEMRISLESGIMKNPYLIEQLDNLLKYFCLPTALQELGSLIPQHLHNEFYHPENILHTLGYDKKNLSKKAVRMVMVEHLGRAASCNGAYCATPHTDILYEVLKSECHVVCNN
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEF1_MOUSE
Sequence: MASYPNGQSCPGAAGQVPGVPPGGYYPGPPHGGGQYGSGLPPGGGYGAPAPGGPYGYPSAGGVPSGTPSGPYGGIPPGGPYGQLPPGGPYGTQPGHYGQGGVPPNVDPEAYSWFQSVDADHSGYISLKELKQALVNSNWSSFNDETCLMMINMFDKTKSGRIDVAGFSALWKFLQQWRNLFQQYDRDRSGSISSTELQQALSQMGYNLSPQFTQLLVSRYCARSAIPAMQLDCFIKVCTQLQVLTEAFREKDTAVQGNIRLSFEDFVTMTASRML
What is the function of this protein?
Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium.  Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats.  In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification.  Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium.  Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (By similarity).  Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity).
What are the official names of this protein?
Peflin, PEF protein with a long N-terminal hydrophobic domain, Penta-EF hand domain-containing protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein. Note=Membrane-associated in the presence of Ca(2+) (By similarity). Localizes to endoplasmic reticulum exit site (ERES) (By similarity).
Protein: RRF_MYCPA
Sequence: MIDEALFDAEEKMEKAVAVARDDLSTIRTGRANPGMFSRIVIDYYGAATPITQLASINVPEARLVVIKPYEASQVGAIETAIRNSDLGVNPTNDGTLIRVAVPQLTEERRRELVKQAKSKGEDAKVSVRNIRRKAMEELHRIRKDGEAGEDEVGRAEKDLDKTTHQYITQIDELVKHKEGELLEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGFI1_RAT
Sequence: MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKSVAPVAPPFSSSSGVLGNGLCELDRLLQELNATQFNITDEIMSQFPSSKMAEGEGKEDQSEDKSITTVPSSTFPAPSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAVSPTREGCPSPPGQTNKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCRGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKPYCQPCFLKLFG
What is the function of this protein?
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus.  Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.  May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity.  In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity.  May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence.  May have a zinc-dependent DNA-binding activity.
What are the official names of this protein?
Transforming growth factor beta-1-induced transcript 1 protein, Androgen receptor-associated protein of 55 kDa, Hydrogen peroxide-inducible clone 5 protein, Hic-5.
What is the protein family that this protein belongs to?
Belongs to the paxillin family.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.
Protein: HUTG_SALAR
Sequence: MTQWYPVSPTLWQGRDDSAEAADARRLFQTVIRSEDFAPQDWPKQIALMGFACDEGVKRNAGRPGAAGAPDALRKALANMASHNGHERLVDLGNWVAQAPDLEGAQQTLRDAVRRCLCAGMRTLVLGGGHETAFGHGAGVLDAFAQESVGIINLDAHLDLRQTERATSGTPFRQLAQLCDAQRRVFHYACFGVSRAANTRALWREATRRNVTVVEDLDCYNALAQMTQFIARVDKIYLTIDLDVLPVWEMPAVSAPAALGVPLIQILRLIEPVCRSGKLQAADLVEFNPRFDKDGAAARVAARLGWQIAHWWR
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: PROA_ESCF3
Sequence: MLEQMGIAAKQASYKLAQLSSREKNRVLEKIADELEAQSESILNANAQDVADARANGLSDAMLDRLALTPARLKGIADDVRQVCNLADPVGQVIDGGVLDSGLRLERRRVPLGVIGVIYEARPNVTVDVASLCLKTGNAVILRGGKETCRTNAATVAVIQDALNSCGLPAGAVQAIDNPDRALVSELLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIYVDESAEIAEALKVIVNAKTQRPSTCNTVETLLVNKNIADSFLPALSKQMAESGVTLHADAGALAQLQTGPAKVVAVKAEEYDDEFLSLDLNVKIVSDLDDAIAHIREHGTQHSDAILTRDMRNAQRFVNEVDSSAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGIGDYTIRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SCM2_MESMA
Sequence: VRDAYIAKPHNCVYECARNEYCNNLCTKNGAKSGYCQWSGKYGNGCWCIELPDNVPIRVPGKCH
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  This toxin is active against both mammals and insects, and is classified as an alpha-like toxin.
What are the official names of this protein?
Alpha-like toxin BmK M2, BmK-M2, BmKM2.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LPTD_BURP1
Sequence: MPPKTLFPLVPACDAAPRKKRLAVALLAVPGLVPAVSQAQLSGAAAEPQAFGSPWDLRLAPQLDEHPQKQGGKPATFVLADHTNGTAEQDLAAKGAAEIRRGNAAVKADAIHYDQDTDMADAYGKVTVANGGTTFSGPEAHLKVEANQGFMTTPKYRFTATGGTGSAERVQLLDSERSVFTNGTYTGCQCSTNPAWYIKGSEFDFDTGADEGVARNGVLFFQGVPLFGSPWLTFPLSGDRRSGFLPPTFSPFSSTNGFELSLPYYFNIAPNRDLTITPHIISKRGIFTQATFRYLSTNYSGTLTGEYLPDDRVAHRNRYAIFWQHQQNFGNGFGGYVYYNKVSDNLYPEELGSTNQFVNGVQTVYQQEAGLTYNNGPWSVLGRYQHWQTLPPSAAPYGREPQLNVKYTKYNVGGFDFGAEADYSRFRITTADQPEGDRVMFNPYVSYGLYGPGYFFVPKAQLHMASYDLTTTTGGVPGQPKRFTYSIPTLSLDTGLVFDRSVRLFGQDFIQTLEPRLFYVYTPYRNQSNAPLFDTAVSDFGLAEIFTPNTFVGNDRIADANRLTAALTTRFINPTTGDERARFVIAQQYYFTDQRVTLLPTEAPATARHSDLILGASVKLGAGFASETAFQYNVDNNQLVKSSVGFGYSPGERRVINVGYRYTRQNPTLSNEPINQILMSAQWPLTRRLYAVGRLNYDLASSRVVDGLVGFQYDADCWAFGVGVQRYANGLNSSGQQNSSTRVLAQLVLKGLTSIDNGLVTAFRAGVQGYTPLPPAPAPLSRFSNYD
What is the function of this protein?
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
What are the official names of this protein?
LPS-assembly protein LptD.
What is the protein family that this protein belongs to?
Belongs to the LptD family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: CZCD_BACSU
Sequence: MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDAGHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEAIERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLGSVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSDIIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHKGITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH
What is the function of this protein?
Involved in divalent cation and potassium homeostasis in the cell.  Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions.
What are the official names of this protein?
Cadmium, cobalt and zinc/H(+)-K(+) antiporter.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLME_BARQU
Sequence: MKKTKKTPTGGYGGSGSHKLYQRVKKKAGTIKASSRRWLERHLNDPYVHQSKVDGYRSRAAYKLIEMNERYKFLKKGQKIIDLGAAPGGWCQVAQRIVGSSDEKPSVVGIDYLPVVPLPGVIMLEMDFLHTDAPQKLIDALGTKPDVVLSDMAAPTTGHRQTDYLRTTYLCEVAADFALSVLKSGGHFLVKAFQGGAENTLLTTLKQNFKTVHHVKPPASRTESVELYLLALEFKAKTEVK
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_BURM1
Sequence: MSGIDPKRFGKVAVLFGGESAEREVSLTSGRLVLQGLRDAGVDAHPFDPAERPLSALKDEGFVRAFNALHGGYGENGQIQGALDFYGIRYTGSGVLGSALGLDKFRTKLVWQQTGVPTPPFETVMRDDDYAARATEIVAKLGLPLFVKPASEGSSVAVLKVKTADALPAALAEAATHDKIVIVEKSIEGGGEYTACIAGDLDLPLIKIVPAGEFYDYHAKYVADDTQYLIPCGLPADQEAQLKRLARRAFDVLGCTDWGRADFMLDAAGNAYFLEVNTAPGMTDHSLPPKAARAIGISYSELVVKVLSLTLND
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_KLEP7
Sequence: MLKQVEIFTDGSCLGNPGPGGYGAIMRYRQHEKTFSAGYRLTTNNRMELMAAIVALEALKEHCEVVLSTDSQYVRQGITQWIHNWKKRGWKTAEKKPVKNVDLWQRLDAALGQHKIKWEWVKGHAGHPENERCDELARAAASHPTLDDVGYLPES
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOKE_SHIFL
Sequence: MLTKYALVAVIVLCLTVLGFTLLVGDSLCEFTVKERNIEFKAVLAYEPKK
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system (By similarity).  When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration (By similarity).  Its toxic effect is probably neutralized by an antisense antitoxin Sok RNA (By similarity).
What are the official names of this protein?
Protein HokE.
What is the protein family that this protein belongs to?
Belongs to the Hok/Gef family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.