PharMolix/UniProtQA huggingface dataset:
Protein: GLMU_ECOLI
Sequence: MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAO1_VIBC3
Sequence: MNNDKRPLYISYAGPALLSTPLLNKGSAFSAEERASFNLEGLLPEATETIQEQVVRAYQQYRGFESDMDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYANRDRIDDLLNNAANHNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLADPMYMGWRHPRITGPDYDNFVEEFMQAVQRRWPDALIQFEDFAQKNAMPLLERYKNRVCCFNDDIQGTAAVTVGSLLAACKAAGSQLSQQRITFLGAGSAGCGIAEAIIAQMVSEGISDEQARSQVYMVDRWGLLEEGMPNLLDFQQRLVQKKANTQHWTTENNGYSLHDVIRNAKPTVLVGVSGAPGLFSEEIIKEMHQHCPRPIVFPLSNPTSRVEALPSDIIRWTNGEALVATGSPFDPVLHEGKTYPIVQCNNSYIFPGIGLGVLAANARRVTDEMLMESSRALASCSPLAINGHGPLLPPLESIHSVSKKIAFAVAKKAIEQGVAPEVTDEALEASIEQHFWQPVYRRYKRTAF
What are the official names of this protein?
NAD-dependent malic enzyme, NAD-ME.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
Protein: LN28B_HUMAN
Sequence: MAEGGASKGGGEEPGKLPEPAEEESQVLRGTGHCKWFNVRMGFGFISMINREGSPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSSKGLESIRVTGPGGSPCLGSERRPKGKTLQKRKPKGDRCYNCGGLDHHAKECSLPPQPKKCHYCQSIMHMVANCPHKNVAQPPASSQGRQEAESQPCTSTLPREVGGGHGCTSPPFPQEARAEISERSGRSPQEASSTKSSIAPEEQSKKGPSVQKRKKT
What is the function of this protein?
Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c.  Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463).  Does not act on pri-miR21 (PubMed:22118463).  The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation.  When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396).  This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463).  Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop.  Mediates MYC-induced let-7 repression (By similarity).  When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7.  Isoform 2 has no effect on cell growth.
What are the official names of this protein?
Protein lin-28 homolog B, Lin-28B.
What is the protein family that this protein belongs to?
Belongs to the lin-28 family.
Protein: RECR_CITK8
Sequence: MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMSEIGHCADCRTFTEQDVCNICSNPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLASEQLSEVILATNPTVEGEATANYIAELCAQYGVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIRF
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: PAPM_STRPR
Sequence: MTAAAPTLAQALDEATGQLTGAGITADAARADTRLLAAHACQVAPGDLDTCLAGPVPPRFWHYVRRRLTREPAERIVGHAYFMGHRFDLAPGVFVPKPETEEITRDAIARLEALVRRGTTAPLVVDLCAGPGTMAVTLARHVPAARVLGIELSQAAARAARRNARGTGARIVQGDARDAFPELSGTVDLVVTNPPYIPIGLRTSAPEVLEHDPPLALWAGEEGLGMIRAMERTAARLLAPGGVLLLEHGSYQLASVPALFRATGRWSHASSRPTCNDGCLTAVRNHTCAPPA
What is the function of this protein?
Involved in pristinamycin I biosynthesis (PubMed:9044253).  Catalyzes the SAM-dependent methylation of 4-amino-L-phenylalanine (PAPA) to 4-methylamino-L-phenylalanine (MMPAPA), and of MMPAPA to 4-dimethylamino-L-phenylalanine (DMPAPA) (PubMed:9044253).
What are the official names of this protein?
4-amino-L-phenylalanine/4-methylamino-L-phenylalanine methyltransferase, PAPA/MMPAPA methyltransferase, SAM:PAPA/MMPAPA N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family.
Protein: KRA63_HUMAN
Sequence: MCGSYYRNYNGGHGYGCCGYGGLGCGYGGCGYGCCGYGGLGFGYGGLDCGYGGLGCGYGSFCGCGYRGLDCGYGCGYGYVSHSFCGCGYRCGSGYGSSFGYYY
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 6-3.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 6 family.
Protein: LMRB_LISMO
Sequence: MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGESGWGSATVLVSIIVGGIALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGVGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK
What is the function of this protein?
Proton-dependent transporter.  May mediate the efflux of lincomycin (By similarity).
What are the official names of this protein?
Lincomycin resistance protein LmrB.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. EmrB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OTASE_ASPNG
Sequence: MVRRIASATPMVQSPMSPLGTTYCVRPNPVSLNLQRRPLVIASTDEAKVTIIYAGLLIPGDGEPLRNAALVISDKIIAFVGSEADIPKKYLRSTQSTHRVPVLMPGLWDCHMHFGGDDDYYNDYTSGLATHPASSGARLARGCWEALQNGYTSYRDLAGYGCEVAKAINDGTIVGPNVYSSGAALSQTAGHGDIFALPAGEVLGSYGVMNPRPGYWGAGPLCIADGVEEVRRAVRLQIRRGAKVIKVMASGGVMSRDDNPNFAQFSPEELKVIVEEAARQNRIVSAHVHGKAGIMAAIKAGCKSLEHVSYADEEVWELMKEKGILYVATRSVIEIFLASNGEGLVKESWAKLQALADSHLKAYQGAIKAGVTIALGTDTAPGGPTALELQFAVERGGMTPLEAIKAATANAPLSVGPQAPLTGQLREGYEADVIALEENPLEDIKVFQEPKAVTHVWKGGKLFKGPGIGPWGEDARNPFL
What is the function of this protein?
Carboxypeptidase that catalyzes the release of a C-terminal amino acid with specific catalytic activity for aromatic amino acids such as phenylalanine (PubMed:24947135, PubMed:33647354).  Is able to degrade ochratoxin A, one of the five major mycotoxins most harmful to humans and animals that is produced by Aspergillus and Penicillium species and occurs in a wide range of agricultural products (PubMed:24947135).
What are the official names of this protein?
Ochratoxinase, OTase, Amidohydrolase 2, Amidase 2, Carboxypeptidase Am2.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Ochratoxinase amidase 2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CSRA_ACIAD
Sequence: MLILTRRVGETLMIGDQVSVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQHERAMHVILAKIMDSTSL
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOC1_PANPR
Sequence: MRLILWLPVLVVVLLMVMEGPAPAQGAPDVASTFRNIPNSLKEFGNNLKDTFESIPEATRKLMTSFAEGIKNFRIPLL
What is the function of this protein?
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor.  Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL.  Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP).  Binds free fatty acids and reduces their intracellular esterification.  Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
What are the official names of this protein?
Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPF_GEOMG
Sequence: MVRVKICGITSLEDALMAVEAGADALGFVFHEDSPRHVPPEQATGIIAGLPPFVQTVGLFVNRPIAYVNETAARCRIDLVQLHGDEPPEFCAAVERRVIKAFRVQDITSLDPIKHYRVAAHLLDAYSPKAYGGTGLTFNWDIAAAAKEFGPVILAGGLTPDNIREAVEAVNPYAVDVSGGVESAPGRKDAAKVREFIRRAKA
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: QUEF_BACCN
Sequence: MAGRLDEDLKDVTLLGNQNTKYLFEYSPEILETFDNNHPNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPEKKMVESKSLKLYLFSFRNHGDFHEDCMNVIMNDLIELMDPRYIEVWGKFTPRGGISIDPYCNYGRPGTKYEKMAEYRMMNHDLYPETVDNR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7S_BACVZ
Sequence: MTETKKSEELTFEEAMKGLEGIVAKLEEGDVPLEQAINYFQEGMALSKMCHEKLQHVEKQMDFILKDNGELAPFSVQEEDEGDK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM198_HUMAN
Sequence: MPGTVATLRFQLLPPEPDDAFWGAPCEQPLERRYQALPALVCIMCCLFGVVYCFFGYRCFKAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLFLVGLLLGLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTGAALIATAADYFAELLLLGRYVVERLRAAPVPPLCWRSWALLALWPLLSLMGVLVQWRVTAEGDSHTEVVISRQRRRVQLMRIRQQEDRKEKRRKKRPPRAPLRGPRAPPRPGPPDPAYRRRPVPIKRFNGDVLSPSYIQSFRDRQTGSSLSSFMASPTDADYEYGSRGPLTACSGPPVRV
What is the function of this protein?
Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling.  May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
What are the official names of this protein?
Transmembrane protein 198.
What is the protein family that this protein belongs to?
Belongs to the TMEM198 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasmic vesicle. Note=Largely located to vesicle-like structures.
Protein: NU6M_SALSA
Sequence: MTYIVSLFLLGLVLGLVAVASNPAPYFAALGLVVAAGVGCGVLVGYGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPFPESWGDRSVLGYVVVYTVGVMLVAGWFWSGWYETSWVVVDEFKEFSVLRGDTSGVALMYSYGGGMLIVCAWVLLLTLFVVLELTRGLSRGALRAV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: UBIE_ROSDO
Sequence: MTDDSNKTTHFGFETVPEGEKAGRVQGVFSSVASKYDIMNDVMSVGIHRLWKEAMMDWLAPRAGQKLLDVAGGTGDISFRFLKRAGYGHATVLDLTESMLVEGRKRAEAAAMADQLDWVTGDAMALPFADNTFDVYTISFGIRNVTRPQEALNEAFRVLRPGGRLMVLEFSQLPNPAMQKAYDLYSFNVIPRMGQAIAGDRDSYQYLVESIRKFPDQDTFLKMVRDAGFENAKFRNLSMGIACLHSGWKL
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: KIF27_HUMAN
Sequence: MEEIPVKVAVRIRPLLCKEALHNHQVCVRVIPNSQQVIIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHIASVVEGQKGIIPRAIQEIFQSISEHPSIDFNVKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECHVESAGEVMSLLEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHIVSKFHFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDRIDEMEFEIKLLREALQSQQAGVSQTTQINREGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAFTFLVDLKDTVRLNEKQQHKLQEWFNMIQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKRELKKCQCVLAADEVVFNQKELEVKELKNQVQMMVQENKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSEELTKLNLSVTSSAKENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQDSRKVHTSPPMYSLDRIFAGFRTRSQMLLGHIEEQDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDSVCSLVELSDTQDETQKSDLENEDLKIDCLQESQELNLQKLKNSERILTEAKQKMRELTINIKMKEDLIKELIKTGNDAKSVSKQYSLKVTKLEHDAEQAKVELIETQKQLQELENKDLSDVAMKVKLQKEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHMKYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEIQLKTGQEEGLKPKAEDLDACNLKRRKGSFGSIDHLQKLDEQKKWLDEEVEKVLNQRQELEELEADLKKREAIVSKKEALLQEKSHLENKKLRSSQALNTDSLKISTRLNLLEQELSEKNVQLQTSTAEEKTKISEQVEVLQKEKDQLQKRRHNVDEKLKNGRVLSPEEEHVLFQLEEGIEALEAAIEYRNESIQNRQKSLRASFHNLSRGEANVLEKLACLSPVEIRTILFRYFNKVVNLREAERKQQLYNEEMKMKVLERDNMVRELESALDHLKLQCDRRLTLQQKEHEQKMQLLLHHFKEQDGEGIMETFKTYEDKIQQLEKDLYFYKKTSRDHKKKLKELVGEAIRRQLAPSEYQEAGDGVLKPEGGGMLSEELKWASRPESMKLSGREREMDSSASSLRTQPNPQKLWEDIPELPPIHSSLAPPSGHMLGNENKTETDDNQFTKSHSRLSSQIQVVGNVGRLHGVTPVKLCRKELRQISALELSLRRSSLGVGIGSMAADSIEVSRKPRDLKT
What is the function of this protein?
Plays an essential role in motile ciliogenesis.
What are the official names of this protein?
Kinesin-like protein KIF27.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Localizes to centrioles and basal bodies.
Protein: RIMP_ECOSE
Sequence: MGLSTLEQKLTEMITAPVEALGFELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPLFTAEHYARFVGEEVTLVLRMAVQNRRKWQGVIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_PSELT
Sequence: MKIPEDIKKRIEKLREEIEYHNYRYYVLADPIISDEEYDRLMQELIELEKKYPELVTPDSPSQRVGEKVLDEFRSVEHSEPMLSLDNTYDEAQIREFDKRVRKLLEKDTIEYVTELKIDGVSVALRYENGRFVLGLSRGDGTRGDDITENLKKVRSIPLILREPVTVEVRGEIYMPTEEFERLNEERKKVDGPLFANPRNATAGTLRQLDTSVIRNRRLDSFIYYVLSPERYGLQTQWDALKWLKKIGFKVNPYSQLCQNIDQVIDYWKQWIEKKSELSYWVDGVVVKVNHFNFQSILGSTSRSPRWAIAFKFPAQRAKTRVLNIIVQVGRTGILTPVAELEPIQLAGTVVKRVSLHNFDYIEEKDIRIGDQVYVEKSGGIIPQVVSVIADERNGSEKKIEIPSKCPVCSGKVGKIDSEDVALRCLNPHCPAKLKRALETFVSRGALNIKGLGEKLIDRLVDSGLVKDIADIFYLTPFELSQLGSGIGQKMIANLLAQIEQAKKTPLHKILTGLGIPLVGEKTARILTQKFRSIKRLLSSSVDELTQIEGIGIEIAKNIREYFDNEKTRQIIGKLEKAGLNLEEKEAVVQSKILSNLTFAVTGTLKNFTRDQIKQLVQSLGGQVTDSVSKSTDYVIVGDNPGSKLTKARNLGVKLLTEDEFLQFVKIDIKNLRQQKLF
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DPHB_ARCFU
Sequence: MLTFVGLGLWDVKDISVKGLEAVREADEVYVEYYTSKLLSSIEEMEEFFGKRVVELERSDLEENSFRLIERAKSKSVVLLVPGDPMVATTHSAIKLEAERKGVKTRIIHGASISTAVCGLTGLHNYRFGKSATVSWHRSQTPVNVIKANRSIDAHTLLFLDLHPEPMTIGHAVENLIAEDAQMKDLYAVGIARAGSGEEVVKCDRLENLKKIDFGKPLHVMVVLAKTLHFMEFECLREFADAPAELERLVA
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine.  The three successive methylation reactions represent the second step of diphthamide biosynthesis.
What are the official names of this protein?
Diphthine synthase, Diphthamide biosynthesis methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the diphthine synthase family.
Protein: YBEY_ENDTX
Sequence: MKKDNNIINFVNFPKQHVPLLKIAAATVLKSEKIKRYQVNFIMVDDKEIRKLNTKYRKIKRITDVISFLVVPEFFMGDIYISKTRSQEQAKEYSNTWQQELAYLVIHGLLHLCGYTDYDAVNKTKMFTKQDKIFKCLFYRL
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURQ_PORGI
Sequence: MFEKITEQPSLYDRLEEKSTREILEDINREDRKVAEAVSRTIPMIERLVEQIIPRMEQGGRLFYMGAGTSGRLGVLDASEIPPTFGMPPTFVIGLIAGGDRALRNPVEKAEDNTERGWEELLSHGVNSSDTVIGIAASGTTPYVIGALREARRHGILTGCICSNIESPLAAEADCPIEVIVGPEYVTGSSRMKSGTAQKMILNMISTSIMIRLGRVKGNRMVNMQLSNNKLIDRGTRMLMSEFDLSYEDARTLLLRYGSVRIASESMKQKPPKK
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: TRMD_CHLCH
Sequence: MRFDVISVIPYFFDSVLTSGLLNIARKKGEVEIYIHNLHDYGLGRYKQVDDAPYGGGAGMVIRPEPVFACIEALQAERHYDAVIFLTPDGELLEQPLANRLSRLENLLLLCGHYKAIDERIREQLITMEISVGDVVLSGGEIPALMLMDAIVRLIPGVLGDSESALTDSFQNGLLDAAYYTRPADFRGMKVPEVLLSGHQAHIEQWRTASALERTKIRRPDLLERAWREEF
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_MYCBP
Sequence: MSASDGNTAELWVPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTEV
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: GATA_DEHM1
Sequence: MTDLIKLTIAQSHKLLKERKLSSAELTRAHLDRIEKLEPEIKAFMTVCPESALAQAKAADEAIKQGHIRPLTGIPMALKDVLCTKGIRTTCSSRMLENFVPPYNAHVVDKLAEEGAVLLGKTNMDEFAMGSSTENSAFFTTHNPWNTAKVPGGSSGGSAACVAASEAVFSLGSDTGGSIRQPASFCSVTGLKPSYGMVSRYGLVAFASSLDQIGPFTKDVLDCALVMNAIAGFDDRDSTSVPQTAPDFSSCLDGDIKGFKLGVPKEYFSHNMRADIAEKINDALGVLSGLGASVDREVSLPHTPYALAVYYILAPSEASANLSRYDGVKYGYSYNQTENMWEAMEKTRAKGFGPEVKRRIMIGTYALSAGYYDAWYVKAQKVRTLISQEFNNAFEKYDALITPTTPNLPFSIGEKLSDPFEMYMCDTCTIPINIAGLPAISIPAGFVDGLPVGLQIIGKPFADQTIMRIAHAFQCATAWHKETPRL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: PANC_RUMCH
Sequence: MKSVNTIHEVKNIVKDWKKQGLSVGLVPTMGYLHEGHGSLILKARENSKVVVSIFVNPMQFGPTEDLEKYPRDLEKDLKYCEELGADLIFSPEPGEMYPEGFCTSVDMSVLTEELCGLSRPSHFKGVCTIVNKLLNIVNPDRAYFGEKDAQQLVIVKRMVRDLNMDIEIVGCPIIREKDGLAKSSRNTYLNSEERRAALVLSKSIFTGKDMVKKGCRETDVLLKKMKAIIDQEPLARIDYLKAVDTMTMQQVDTIDRPVLIAMAVYIGNVRLIDNFSFIPD
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.