PharMolix/UniProtQA huggingface dataset:
Protein: LUXS_WOLSU
Sequence: MPLLDSFKVDHTKMPAPAVRLAKTMTTPKGDEIAVFDLRFCRPNQEILSEKGIHTLEHLFAGFMREHLNGEGIEIIDISPMGCRTGFYMSLIGVPKNARVLEAWRRSMEDILTLKSEEEIPELNIYQCGTACMHSLKEAQEIARTVLDRGISIMDNEALKLQL
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: TMM64_HUMAN
Sequence: MRSPGGILLQALPRLLQHAALPGLAELPARWALPRGAGGDGPADRLPRGGGASAAAAAAAASGALLGAYLERHGPPEASELPEPGGALAGGPGSGGGGVVVGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRRYLHHLLLWVESLDSLLGVLLFVVGFIVVSFPCGWGYIVLNVAAGYLYGFVLGMGLMMVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLSAVIRVVEGGSGLKVVALARLTPIPFGLQNAVFSITDLSLPNYLMASSVGLLPTQLLNSYLGTTLRTMEDVIAEQSVSGYFVFCLQIIISIGLMFYVVHRAQVELNAAIVACEMELKSSLVKGNQPNTSGSSFYNKRTLTFSGGGINVV
What is the function of this protein?
Positively regulates TNFSF11-induced osteoclast differentiation.  Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation.  Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation.  Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway.  Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.
What are the official names of this protein?
Transmembrane protein 64.
What is the protein family that this protein belongs to?
Belongs to the TVP38/TMEM64 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein: HUNB_DROTA
Sequence: WYSSMFAANIKQEPISHHHHHHHAHHSHHADSNSNASSPHQSPLPSPNPPSNTNLQLEQYLKQQQQQQQQHQQQQQPMDTLCAAAMTPSPSNNDQNSPLMWSGLPNPMQTIMPANMRPSPTAATAATTTELCAPTTTTAAIALQANDKLQALTPPMDVTPPKSPAKSQQSCAEPEKEHDLMSNSSEDMKYMA
What is the function of this protein?
Gap class segmentation protein that controls development of head structures.
What are the official names of this protein?
Protein hunchback.
What is the protein family that this protein belongs to?
Belongs to the hunchback C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NRAC_BOVIN
Sequence: MKTAVHALSPDSRPETQHQTRKNEEAAPGSPTPRAGREGRKGPASILRRSPQERCGRGDEPRRTTRHVRFREPLEVAVHYIACREPTTAVQAPSRPRPRGGSLLLRLTACILLALALGMCCGQAGPMARALEDFRARLLAALLRLPLAALDCWRCLLQL
What are the official names of this protein?
Nutritionally-regulated adipose and cardiac-enriched protein homolog.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: NHAA1_MAGMM
Sequence: MNRWLKNMLHNEAASGVLIFLAAVAAMLIENSSLEPYYNSFLNIPVAVQFSELKIAKPLLLWINDGLMAVFFLLVGLELKREFLEGQLAQPANVVLPVVGAVGGIVGPALIYVMFNYTNPVALQGWAVPTATDIAFAMGVLALLGKRVPAAIKLFLLTLAIIDDLVAIVIIAIFYTSDLSVGSLTVAGGAIALLFLLNRIGVKGIAPYVLVGMVLWVAVLKSGVHATLAGVVLAMAIPIKGETPEHGSPLHALEHDLHHVVGLVILPLFAFANAGVSLAGLGLNVLLEPVAMGIGLGLLLGKQIGVMGAVWLANLLGVAKKPESLSWTQLYGVALLCGIGFTMSLFISSLAFEHSGAQVVAGAADAGHARLGILSGSLVSGVLGYLVLRFSLARKG
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYB_PELMG
Sequence: MAPNIRKSHPLLKMINNSLIDLPSPSNISAWWNFGSLLGICLMTQILTGLLLATHYTADTTLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFMIAGLTTIHLTFLHESGSNNPLGITSNCDKIPFHPYFTLKDILGFTLMLLPLTILALFSPNLLGDPENFTPANPLITPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLTPFLHKAKQRTMTFRPISQLLFWILVTNLLILTWVGSQPVEHPFIIIGQLASITYFTILLILFPITGALENKMLNY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BCHB_HELMI
Sequence: MKLAYWMYEGTALSGIARVAGSMPKVHTVIHGPQGDGYINVMFSMLERFHKLPPFTLSPIGRREMARGSRARLVETVRRVDALHQPDVIVITPTCSSTLLQEDLLAVANSLGRQTKARLIVPQVNAFRDLEHFAMDDFLAQMVAAFAVEQPKTERFTVNLIGPSYLGFHQIHDLNEIRTMLEEIGIGVNAVIPYGATVETLRSLTRAHLNICLYREYGRETCEYLRKRFGIDYISITPMGIRQTGRFLRALGEQAGIDVTPYIRRHLAPSGALARFTKSVDALSSLFGKRAVVFGDFSHAVGATYLLREIGLQVVWAGTYMTAWKDEFTEAVAALTDEAFVCDDFQAVSRKIRDTQPDIVFGTQMERHSAARYELPCIVISSPAHILNFPLFPAPVLGYRGMTRLLDTINQTIKLGLEEHLVNMFGEDTASERQMEAASAAARGTATAPTGAAGAVATVDELQWDAEAEKALKQVPFFVRGKVQRNTENYARERGYSEVTLDVIYAAKAYFEGKGNQGNR
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex (By similarity).
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: RL13_LUMRU
Sequence: MFNQPARKERRRVARRKKALAIAPRPAAGSLRPQVRCQTFKYNTRLREGRGFSLDELKAAGINKKEARAIGISVDVRRRNKSVESLQLNVQRLKEYRSKLILFPKKLSKPNKGDATEEEMKLATQLKGKLLPRTAWIKPEKARAITDEERKVKVFDRLRQARAHKRLAGKRAKKAKEAGGEVAGGEKA
What are the official names of this protein?
60S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL13 family.
Protein: ACCD_ACTSZ
Sequence: MSWIDKIFSKKPSSDSRRANVPEGVWTKCTACEQVLYRDELKRHLEVCPKCGHHMRIDARERLEYLLDKDSMTEIAADLEPKDILKFKDLKKYKDRLSAAQKDTGEKDALVAMSGTLYGMPIVAAASNFAFMGGSMGSVVGAKFVQAAEEAIEKNCPFVCFSASGGARMQEALLSLMQMAKTSAVLAKMKEKGVPFISVLTDPTLGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPEGFQRAEFLLEHGAIDMIIQRSEMREKLASILSKLMNKPSPFLEPEIIAD
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C3H58_ARATH
Sequence: MERYGGAGEDESRSDPSHEWSAQGTETGIEASMWRLGLRGGGGGGETFPERPDEPDCIYYLRTGVCGYGSRCRFNHPRNRAPVLGGLRTEAGEFPERMGQPVCQHFMRTGTCKFGASCKYHHPRQGGGGDSVTPVSLNYMGFPLRPGEKECSYFMRTGQCKFGSTCRYHHPVPPGVQAPSQQQQQQLSAGPTMYPSLQSQTVPSSQQYGVVLARPQLLPGSYVQSPYGYGQMVLPPGMVPYSGWNPYQASVSAMPSPGTQPSMGTSSVYGITPLSPSAPAYQSGPSSTGVSNKEQTFPQRPEQPECQYFMRTGDCKFGTSCRFHHPMEAASPEASTLSHIGLPLRPGAVPCTHFAQHGICKFGPACKFDHSLGSSSLSYSPSPSSLTDMPVAPYPSSLGTLAPSSSSDQCTELISSSSIEPITTTTGGSETVAAGVSSMTSDVSHPEPAETNKGDSASNEAKTSS
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 58, AtC3H58, Zinc finger CCCH domain-containing protein ZFN-like 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS12_METBU
Sequence: MPNGKYAAHRLQQVRKDARWKDTGYSRRTLGLDIKSDPLSGAPQGRGIVLEKVGVEAKQPNSAIRKCVRIQLIKNGRQATAFCPGDGAINFIDEHDEVTVERIGGRMGGAMGDIPGVRFKVIAVNNVSLREMVIGRKEKPRR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PAL1F_EUGGR
Sequence: MYILVWKEGQQIRTFQDLEESVQFRTASNITDGQIFSINVTPTMGKGGETGETQLRRLMYLSASTEPENCNADYVGDMAHFATLRNKSIGVSGFYMYSAPFLFQVIQGTDEDLDFLCANGSADPRHQRCIELADGPTTGRMYGWWHLKDSHIDNITKDPAIKTILIEIARSFSSMWSYLPRNAANMVLLGKNPNKQAPEPMSVVVTVIYLVEFSVIMAHPGLSEQCPDILPAFVDACVPHVDGTGGEVAKFIIAICMAYWPINSDEHALVGLQQLSDDLAELRSLQEDGSARSLIYSRCGLHFGRAMLCNAGFRKADFTLLGDWINSASRITSLSVNSKVPLLLSFLVRCLLGDEMRVELERSGLHKVGGRVKPVQVYQFNAPELDTATVRGEIKQFNPGRERALCPVKPYESLHPAHPDPIFDDTPRENQPELSQVQRRDSLVDRLSQIAKLAFPSSMMAGGEGQLITLTYISQAAHPVSRLDLASIQRIAFARNESSNITKSLLYVSGLFVQTLEGTKGAVVSLYLKNRQDKRHKDVVAAFMAPIDEGVYGSPLDMTSATEEMLATFTPLHDVLSQLAKSFISLETYVPSTVVRHLAAGNNPRNLQPVSVEVVMLATAISSFTPLSEKCSLTEVWTICNTFIVACTSAICNEGGEVIKLIGDCVPAYFPPTNADNAVHACQEIVSFCAQLRAAFHDVLDCRSVVACGVGLDYGQVIMVQCGSLGMTEFVVAGEVRARVLEVEALTREAGRAIVITEPVPERQSPKLRDTGIVPCQEGVDGARCYGILGPEWELDVATIKKNINGFLKDARALAANKKVDDGTNISCRGGNPPAGGIPTSPKVRPPGRTNSVSSYTPDPKQALDPRMAESVFLDMCHQGDTVNNSIAVKLGLAANEDGFDGGWILTWYVELMPVKQAIKVLTQLRIGNMSDNFVDDNNVGELLEKCIPTRSLQVLDLSNNPGLTKVIALKPKHNTQVREILLNGTRIAPTEQRKQQTSKNVNRLCASTDLKGSHKYEH
What are the official names of this protein?
Photoactivated adenylate cyclase subunit alpha-like protein 1224-5/1F.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Note=Paraxonemal body. And paraxonemal bodies (PABs).
Protein: PSBH_POPAL
Sequence: MATQSVEGSSRSGPRRTIVGDLLKPLNSEYGKVAPGWGTTPLMGVAMALFAVFLSIILEIYNSSVLLDGISMN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H, Photosystem II 10 kDa phosphoprotein.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CO6A6_MOUSE
Sequence: MLLVLCLTMICFHVCVNQDSGPEYADVVFLVDSSDHLGLKSFPLVKTFIHKMISSLPIEANKYRVALAQYSDALHNEFQLGTFKNRNPMLNHLKKNFGFIGGSLKIGNALQEAHRTYFSAPTNGRDKKQFPPILVVLASAESEDDVEEAAKALREDGVKIISVGVQKASEENLKAMATSQFHFNLRTARDLSVFAPNMTEIIKDVTQYREGMADDIIVEACQGPSVADVVFLLDMAINGSQEDLDHLKAFLGESISALDIKENCMRVGLVTYSNETRVISSLSTGNNKTEVLQRIQDLSPQVGQAYTGAALRKTRKEIFSAQRGSRKNQGVPQIAVLVTHRASEDNVTKAAVNLRREGVTIFTMGIEGANPDELEKIASHPAEQFTSKLGNFSELATHNQTFLKKLRNQITHTVSVFSERTETLKSACVDTEEADIYLLIDGSGSTQPTDFHEMKTFLSEVVGMFNIAPHKVRVGAVQYADTWDLEFEISKYSNKPDLGKAIENIRQMGGNTNTGAALNFTLKLLQRAKKERGSKVPCHLVVLTNGMSRDSVLGPAHKLREENIRVHAIGVKEANQTQLREIAGEEKRVYYVHEFDALRNIRNQVVQEICAEEACRDMKADIMFLVDSSGSIGPENFSKMKMFMKNLVSKSQIGADRVQIGVVQFSHENKEEFQLNTFMSQSDIANAIDRMTHIGETTLTGSALTFVSQYFSPDKGARPNVRKFLILITDGEAQDIVRDPAIALRKEGVIIYSVGVFGSNVTQLEEISGKPEMVFYVENFDILQHIEDDLVLGICSPREECKRIEVLDVVFVIDSSGSIDYQEYNIMKDFMIGLVKKADVGKNQVRFGALKYADDPEVLFYLDELGTKLEVVSVLQNDHPMGGNTYTAEALAFSDHMFTEARGSRLHKGVPQVLIVITDGESHDAEKLNTTAKALRDKGILVLAVGIAGANSWELLAMAGSSDKYYFVETFGGLKGIFSDVSASVCNSSKVDCEIEKVDLVFLMDGSNSIHPDDFQKMKGFLVSVVQDFDVSLNRVRIGVAQFSDSYRSEFLLGTFTGEREISTQIEGIQQIFGYTHIGDALRKVKYYFQPDMGSRINAGTPQVLLVLTDGRSQDEVAQAAEELRHKGVDIYSVGIGDVDDQELVQITGTAEKKLTVHNFDELKKVKKRIVRNICTSGGESNCFVDVVVGFDISSLQRGQTLLEGQPWMGSYLQDLLRAISSLNGVSCEVGTETQVSIAFQVTNAMERYPSKFEIYSENILSSLQGVTVNGPSRLNANLLSSLWDTFQNKSAARGKVVLLFSDGLDDGIEKLEQKSDELRKEGLNALITIAVDGAADSSDLADLLYIEFGKGFEYRTQFTIGMRNLGSQLSRQLINVAERTCCCLLCKCTGGDGAMGDPGSAGKKGPPGFKGSDGYLGEEGIAGERGASGPMGEQGTKGCFGAKGPKGTRGLSGEEGEVGEDGLDGLDGEQGDHGIPGRRGEKGDEGSQGNPGRRGAAGDRGAKGLRGDPGTPGRDSSIQGPKGLKGDLGRQGRRGWPGSPGTPGSRRKMVVHGRRGHIGPQGNPGTPGPDGLAGSPGLRGPQGPRGEVGEKGEKGSLGMKGPQGPPGPGGQAGSQGHLGSQGNKGEPGDLGEKGAAGFPGPRGLQGDDGSPGYGSIGRKGTKGQEGFPGESGLKGDIGDPGDPGEAGPKGARGKTVSAGIPGEPGSPGEPGPPGRKGVKGARGLASFSTCDLIQYVRDHSPGRHGKPECPVHPTELVFVLDQSRDVTEQDFERMKGMMVSLVRDVKVREANCPVGARVAILAYNSHTRHLIRFSDAYRKDQLLTAIKALPYERSSDSREIGKAMRFISRNVFKRTLPGAHVRRIATFFSSGPSADAQTITTAAMEFSALDIVPVVIAFSNVPSVKRAFSIDDTGTFQVIVVPSGSDEGPALERLQRCTFCYDLCKPDASCDQAKPPPIQSYLDTAFLLDGSRHVGSAEFEDMRDFLEALLDHFEITSEPETSVTGDRVALLSHAPLDFLPNTQRSPVRTEFNLTSYSSKRLMKRHVDQAVQQLHGDAFLGHALGWALDNVFLNTPNLRRNKVIFVISAGETSHLDAETLKKESLRAKCHGYALFVFSLGPDWDDKELEDLASHPVDQHLIQLGRIHKPDHGYSVKFVKSFINSIRHGINKYPPVNLKAKCNRLGSRDLKPPPRQFRSFVPGPQKANLKDHTAEAAKLFQDKKRLSSMLKGGRATISSLSRSTRYAFKQGKEAIKATSKLGKRSA
What is the function of this protein?
Collagen VI acts as a cell-binding protein.
What are the official names of this protein?
Collagen alpha-6(VI) chain.
What is the protein family that this protein belongs to?
Belongs to the type VI collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Note=Deposed in the extracellular matrix of skeletal muscle.
Protein: DNAA_BACLD
Sequence: MKNISDLWNQALGQIEKKLSKPSFETWMKSTKAHSLQGDTLIITAPNEFARDWLESRYLHLIADTIYDLTGEELSIKFVIPQNQNEEDFMPKSPIKKMSKEEPADFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNTLHEETKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPSSKPKVITIKDIQRIVGQQFNIKLEDFKAKKRTKSVAFPRQIAMYLSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLSDDEQLQQQIKEIKEQLR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP2S_GIBZE
Sequence: MLSFILIQNRQGKTRLAKWYAPFSDEQKIKLKGEVHRLVAPRDQKYQSNFVEFRNNKIVYRRYAGLFFCACVDTNDNELAFLEAIHFFVEVLDAFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE
What is the function of this protein?
Component of the adaptor complexes which link clathrin to receptors in coated vesicles.  Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).
What are the official names of this protein?
AP-2 complex subunit sigma, Adaptin small chain, Clathrin assembly protein 2 sigma small chain, Sigma2-adaptin.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes small subunit family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of the plasma membrane coated vesicles.
Protein: APD_BOMTE
Sequence: ANRPVYIPPPRPPHPRL
What is the function of this protein?
Antimicrobial peptide active against many Gram-negative enterobacterial and plant-associated bacterial species.  Not active against other bacterial species like H. pylori, P. mirabilis, B. pertussis or N. gonorrhoeae.
What are the official names of this protein?
Apidaecin +A.
What is the protein family that this protein belongs to?
Belongs to the apidaecin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNME_HAEIN
Sequence: MKETIVAQATAPGRGGIGILRVSGPLATKVAQAILGKCPKPRMADYLPFKDADGTILDQGIALYFKSPNSFTGEDVLELQGHGGQVVLDLLLKRILQIDGIRLARPGEFSEQAFLNDKLDLAQAEAIADLIDATSEQAVRSALKSLQGEFSKKVNELVDSVIYLRTYVEASIDFPDEEIDFLADGKIEANLRGIINQLEDVRSEAKQGSILREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLRDAIDEVERIGISRAWTEIEQADRIILMLDSSDPESADLSKVRSEFLAKLPSTLPVTIVRNKIDLNGEQASESEQGGYQMISLSAQTHDGVQLLREHLKQAMGFQTGMEGGFLARRRHLDALDKAAEHLQIGLVQLTEFHAGELLAEELRLVQSYLSEITGQFTSDDLLGNIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OMPU_VIBC3
Sequence: MNKTLIALAVSAAAVATGAYADGINQSGDKAGSTVYSAKGTSLEVGGRAEARLSLKDGKAQDNSRVRLNFLGKAEINDSLYGVGFYEGEFTTNDQGKNASNNSLDNRYTYAGIGGTYGEVTYGKNDGALGVITDFTDIMSYHGNTAAEKIAVADRVDNMLAYKGQFGDLGVKASYRFADRNAVDAMGNVVTETNAAKYSDNGEDGYSLSAIYTFGDTGFNVGAGYADQDDQNEYMLAASYRMENLYFAGLFTDGELAKDVDYTGYELAAGYKLGQAAFTATYNNAETAKKTSADNFAIDATYYFKPNFRSYISYQFNLLDSDKASKVASEDELAIGLRYDF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Outer membrane protein U, Porin OmpU.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: FMT_LATSS
Sequence: MTSIVFMGTPQFSVPILEALVANDYQILAVVTQPDRKVGRKQVLQQTPVKEAAVRLDLPVFQPEKLSGSPELADVIALQPDLIVTAAYGQFLPTKLLEAAKIAAINVHGSLLPKYRGGAPIQYAVLNGDSEIGITIMHMAKKMDAGDMIEQASIPIEATDDTGSLFDKLSYVGRDLLLKTLPGIIAQTAPRTPQDEVQVTFAYNITKEQEQLDINQPAEQLLNQIRALRPQPGAWLAVNGQRTKIWQATVAETTTDQAAGVVVALNKKDFELAAGNGTVLKITEIQPAGKAKMPVQSYLNGVGKQLAVGQQVVVQDAE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: FABV_BURM9
Sequence: MIIKPRVRGFICVTTHPAGCAASVREQIAYVARRGPIERGPKKVLVIGASTGYGLAARIAAAFGVGAATLGVFFERAPADAKPGTAGWYNSAAFHDEAAARGLQATSVNGDAFSDEIKHKTIDAIRRDLGQVDLVVYSVAAPRRTHPKTGVTHQSTLKPIGHAVRLRGIDTDNEAIKETLLQPATPDEIADTVAVMGGEDWRMWIDALDAAGVLADGAKTTAFTYLGEQVTHDIYWNGSIGEAKKDLDRTVLALRGKLAARGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKARSTHEGCIEQVDGLLRDSLYSAQPHVDAEGRLRADRLELDPAVQARVLELWDQVTDDNLYTLTDFAGYKAEFLRLFGFGIDGVDYDAPVEPNVRIPNLIE
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: IGFN1_HUMAN
Sequence: MAGKLRKSHIPGVSIWQLVEEIPEGCSTPDFEQKPVTSALPEGKNAVFRAVVCGEPRPEVRWQNSKGDLSDSSKYKISSSPGSKEHVLQINKLTGEDTDLYRCTAVNAYGEAACSVRLTVIEVGFRKNRKRHREPQEDLRKELMDFRKLLKKRAPPAPKKKMDLEQIWQLLMTADRKDYEKICLKYGIVDYRGMLRRLQEMKKEQEDKMAQYINTISSLRHIRVTKDGNAKFDLELDLKDSQSKIYLYKDGEMIPYGFNNQTKHCLRRLGKRYEFQIQDLRPEDSGIYQVKVEDAVVFSTELEASAIPPRVVVPLAETHCEEQGDAVFECTLSSPCPSAAWHFRHRLLHPSDKYEVYVSPDGLTHRLVVRGARFSDMGPYSLGTGLYTSSAWLVVEAGKDKDLQSTSADHKLQSRRSGKDGRLDIYGERRDATRSSTSRYKPGTGSFSKDAQGPMGHFSQGLADMEVQPGEAATLSCTLTSDLGPGTWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTFVAGDQQSEATLTVQDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAAWRKDGAEVVGSSDREAQVDLGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQGPMEVQDCHRAGVCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHVEPGRKYTFRVRAVTSEGAGEALESEEILVAPEALPKAPSAPAILSASSQGITLTWTAPRGPGSAHILGYLIERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTAVAPSGPGEPGPPSDAVFARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSLQWLPCHVGTVPVTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLVQAMPVTVCPKFLVDSSTKDLLTVKVGDTVRVPVSFEAMPMPEVTWLKDGLPLPKRSVTVTKDGLTQLLIPVAGLSDSGLYTVVLRTLQGKEVAHSFRIRVAACPQAPGPIHLQENVPGTVTAEWEPSPDEAQDVPLHYAVFTRSSAHGPWHEAADRIHTNRFTLLGILPGHEYHFRVVAKNELGASKPSDTSQPWCIPRQRDRFTVKAPCYREPDLSQKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGNPAVYSTDLLGVCSLTIPSVSPKDSGEYKAVAENTLGQAVSTATLIVIEPST
What are the official names of this protein?
Immunoglobulin-like and fibronectin type III domain-containing protein 1, EEF1A2-binding protein 1, KY-interacting protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
Protein: 4HYPE_BURCH
Sequence: MKRIQIIDSHTGGEPTRLVVSGFPSLGRGTMAERRDVLAREHDRYRTACILEPRGSDVMVGALLCDPVAPDAAAGVIFFNNSGYLGMCGHGTIGVVRTLHHMGRIEPGVHRIETPVGTVEATLHDDLSVSVRNVPAYRHAQGVVLDVPGYGPVKGDIAWGGNWFFLISDHGQRVAGDNVAALTAYASAVREGLERAGITGANGGEIDHIELFADDPEHDSRSFVLCPGLAYDRSPCGTGTSAKLACLAADGKLAPGVVWRQASVIGSVFHASYELADGGIVPTIRGSAHLSAEATLLIDEDDPFGWGIGS
What is the function of this protein?
Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4-hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases.
What are the official names of this protein?
4-hydroxyproline epimerase, Hydroxyproline-2-epimerase, HyPRE.
What is the protein family that this protein belongs to?
Belongs to the proline racemase family.
Protein: PTG3C_STAES
Sequence: MFKKLFGQMQRIGKALMLPVAILPAAGLLLAIGTAFQGEALQHYLPFIKNDIVQQIANMLTGAGGIIFDNLPIIFALGVAIGLAGGDGVAAIAAFVGFIILNKTMGAFLHVTPDKLSDPTNGYANVLGIPTLQTGVFGGIIIGALAAWCYNKFYNITLPSYLGFFAGKRFVPIMMATTSFILAFPMAIIWPTIQNGLNAFSEGLLDSNTGLAVFLFGFIKRLLIPFGLHHIFHAPFWFEFGSWKNAAGEIIRGDQRIFIEQIREGAHLTSGKFMQGEFPVMMFGLPAAALAIYQTAKPENKKVVAGLMISAALTSFLTGITEPLEFSFLFVAPFLFVIHAVLDGLSFLTLYLLNVHLGYTFSGGFIDYVLLGILPNKTAWWLVIPVGIIYAVIYYFVFRFLIVKFNYKTPGREDKKSSVTTTSASQLPFDVLKAMGGKENIKHLDACITRLRVEVNEKSKVDVAGLKSLGASGVLEVGNNMQAIFGPKSDQIKHDMAKIISGEITKPSETTIDEEVSDDPVHVEDIVETEIYAPGHGEIIPLSEVPDKVFSEKMMGDGIGFVPDSGEIVAPFDGTVKTIFPTKHAIGLESDSGVEVLIHIGIDTVKLNGEGFESLVNTDEPVTQGQPLMKIDLEYLKEHAPSIITPVIITNQEDKTLTIEDVKQVDPGKAIMTIK
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  This system is involved in glucose transport.
What are the official names of this protein?
PTS system glucose-specific EIICBA component, EIICBA-Glc, EII-Glc, EIICBA-Glc 1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.