PharMolix/UniProtQA huggingface dataset:
Protein: MTLD_SHIBS
Sequence: MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVNAVSSIGDDVVDLIAQVDLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPSMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAILDEKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYSLPHKNLIQGIAGAMHFRSEDDPQAQELAALIADKGPQAALAQISGLDANSEVVSEAVTAYKAMQ
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: OR4E2_HUMAN
Sequence: MDSLNQTRVTEFVFLGLTDNRVLEMLFFMAFSAIYMLTLSGNILIIIATVFTPSLHTPMYFFLSNLSFIDICHSSVTVPKMLEGLLLERKTISFDNCITQLFFLHLFACAEIFLLIIVAYDRYVAICTPLHYPNVMNMRVCIQLVFALWLGGTVHSLGQTFLTIRLPYCGPNIIDSYFCDVPLVIKLACTDTYLTGILIVTNSGTISLSCFLAVVTSYMVILVSLRKHSAEGRQKALSTCSAHFMVVALFFGPCIFIYTRPDTSFSIDKVVSVFYTVVTPLLNPFIYTLRNEEVKSAMKQLRQRQVFFTKSYT
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 4E2, Olfactory receptor OR14-42.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECF_STAES
Sequence: MKLNTLQLENYRNYEQVTLDCHPEVNILIGENAQGKTNLLESIYTLALAKSHRTSNDKELIRFKSDYAKIEGELSYRHGTMPLTMFITKKGKQVKVNHLEQSRLTQYIGHLNVVLFAPEDLNIVKGSPQIRRRFIDMELGQISAVYLNDLAQYQRILKQKNNYLKQLQIGQKTDTTMLEVLNQQFVEYALKVTLRREHFIKELETLAQPIHAGITNDQETLTLDYVPSLKLSNYEANQSELIEEVLALLNDNLQREKERGVCLYGPHRDDLSFNVNGMDAQTYGSQGQQRTTALSIKLAEIELMNIEVGEYPILLLDDVLSELDDSRQTHLLSTIQHKVQTFVTTTSVEGIDHEIMNNAKLYRISQGEILK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_SALCH
Sequence: MKSLQALFGGTFDPVHYGHLKPVETLANLIGLSRVIIMPNNVPPHRPQPEASSAQRKYMLELAIADKPLFTLDERELQRNAPSYTAQTLKAWREEQGPEAPLAFIIGQDSLLNFPTWHDYDTILDNTHLIVCRRPGYPLEMTQAQHQQWLEQHLTHTPDDLHQLPAGKIYLAETPWLNISATLIRERLEKGESCDDLLPENVLNYINQQGLYR
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: PAGP_ERWSE
Sequence: MKLKPVLYLLMLLGCLGLKSAHAATLAHGISASWHSFSQKWNEPQTFDPYIPSIIWHNRWTYDADKIDKYNERPWGAGGGVSHFDKKGNWNGIYLMAFKDSFNKWELISGYGWEKTWRPLSDPDFHLGLGYTAGVTMRDNWSYIPIPVLLPLASIGYEYVSFQMTYIPGTYNNGNVYFAWLRWQL
What is the function of this protein?
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.
What are the official names of this protein?
Lipid A acyltransferase PagP, Lipid A acylation protein.
What is the protein family that this protein belongs to?
Belongs to the lipid A palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: CCA_GEOTN
Sequence: MKPPFQQALGIIRQLNRHGYEAYFVGGAVRDLLLGRPIGDVDIATSALPDEVMAIFPKTIDVGSKHGTVVVVHEGTAYEVTTFRTDGDYEDHRRPESVTFVRSLEEDLKRRDFTMNAIAMDEHGTIIDPFGGQEAIEKRLIRTVGEADARFREDALRMMRAVRFVSQLGFSLAIDTKKAIIANAPLLAHISVERMTMEMEKLLAGPFAAEALPLLAETGLSTYLPGLAEKGEWLRRAAAYRWPWLAAREERWALLCHALGVKESRPFLRAWKLPNKVIDEAGAILATLAAVPEPAAWTNEQLFLAGLKRALSVEVVRAALTGKPYEPQHDELRRRFAALPIKTKGELAVNGKVVIDWIGKPAGPWVKETLDAIWRAVVNGEVENEKERIYAWLMERSRTQEKNC
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: CACO2_BOVIN
Sequence: MEETVDDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDITCYYTLTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPVDLNSESAKQQEVQFKAYYLPKDDEYYQFCYVDQDGVVRGASIPFQFRPENEEDILVVTTQSEVEEIEQHNKELCKENRELKDSCVSLQKQNSDMQATLQKKQEELETLKSINKKLEQTMKEQKDCWEIELLQLKEQNQKMSSENEKMGVRVDQLQAQLSNQGREMEKLVQGVQDKTEQLEHLKEENGQLFLSLTEQREHQKKLEQTVEEMKQKETTAAKKQQELTDQNMDLSKRLSENMIIHDVLQREKEKMEKENDYLKRENNRLLSYMGLDCDSLSYQVPTSNQGGTRQDPGLVFGNPYSGIQESSAPSLLSIKKCPTCKSDFAADVFDHNLALEQHLQTLSLNCPICDKTFPAKEKQIFEDHVFCHTL
What is the function of this protein?
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity).  Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity).  Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (By similarity).  Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (By similarity).  May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (By similarity).
What are the official names of this protein?
Calcium-binding and coiled-coil domain-containing protein 2, Antigen nuclear dot 52 kDa protein, Nuclear domain 10 protein NDP52, Nuclear domain 10 protein 52, Nuclear dot protein 52.
What is the protein family that this protein belongs to?
Belongs to the CALCOCO family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
Protein: CUMC_CONCL
Sequence: GRPSARYDAPYCSQEEVRECDDDCSGNPVRDACQCAYDPAGSPACDCFCVEPWRR
What is the function of this protein?
Probable neurotoxin with unknown target.  Possibly targets ion channels.
What are the official names of this protein?
Conotoxin Cal22c.
What are the subcellular locations of this protein?
Secreted.
Protein: ACY2_HUMAN
Sequence: MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKKCTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTKLTLNAKSIRCCLH
What is the function of this protein?
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate.  NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter.  In other tissues it acts as a scavenger of NAA from body fluids.
What are the official names of this protein?
Aspartoacylase, Aminoacylase-2, ACY-2.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: APGM_SULIY
Sequence: MKQYKILLIIADGLGDRPVSKLNGLTPLEAANKPAISDLLKNSMIGLMDPISPGVIPGSDTSHLSIFGLDPHVYYRGRGAFEALGAGATLKHGDVAFRGNFATVNNDLVVVDRRAGRKLEEGEELVKELNEKIKEINDVKIRFYKGTEHRVAVVLSGKGISDKVSDTDPHYEGLKVLESKPLEDSTEALRTAEIINILTRKVFDVLNSSEVNKRRIEQGEKPANIVLLRGAAHYIKLPSFSSYTKLKAAAVSATALIKGICRELGMNVVTPVGATGGIDTDYNAKAKAAIELLKENDFVFLHIKATDAASHDGLVEEKVKAIERIDKVIGTIVDNVGRDNLILMFTGDHATPVEVKEHSGDPVPILLYVPYPIINDNVRDFNEKEARKGSLRIRGLDVTNILLNYSNRAEKYGA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, aPGAM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Protein: SYA_METEP
Sequence: MSGVNEIRSTFLDYFRDAGHAVVPSSSLVPKNDPTLMFTNAGMVQFKNVFTGVEKRPYVKATSSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKADAIELAWTLITKEFGLSPEKLLVTVYADDEEAAGLWRKIAGFSDEKIIRIGTSDNFWQMGDTGPCGPCSEIFIDQGPTLAGGPPGSPDEDGDRFLEFWNLVFMQYEQVEPGVRNSLPRPSIDTGMGLERMAAILQGVHSNYDTDLFRALIDAVAHAVSRAPEPSTRASYRVIADHLRSTSFLIADGVLPSNEGRGYVLRRIMRRAMRHLELLGARDPVMYRLVPTLVREMGQAFPELARSEALISETLRLEEGRFRKTLERGLAILDTETRDLAAGQNLSGETAFTLYDTYGFPLDLTQDALKARGIGVDTKAFDAAMLRQKQAARAAWQGSGEAATETVWFGIKERTGATEFLGYDTEAAEAVIGALLRDGAEVETLKAGENGIVVANQTPFYGESGGQVGDTGTISGPGLKARVTGTEKKLGDLFVHHVTVEEGTLAVGAAVELKVDHARRAAIRANHSATHLLHEALRQVLGDHVAQKGSLVAPERLRFDISHPKPIDEAELSRVEEIANAVLLQNAPVVTKLMAVDEAIESGARALFGEKYGDEVRVVSMGRPVDDEGREVEGRLPNFSIELCGGTHVSQLGEIGQITVLGESAVGAGVRRIEAMTGTAARRHRATESRTLSQLAGLLKAPVADVPERLSTLIEERRRLEKELADARKKIAMGGASGGGDEAREINGVKLMARVVEGVEMRDLKGLADEGKTRLGSGIVALVGVSADGKAGLVVGVTEDLTGRYDAVELVRAGAGHLGGKGGGGRRDMAQAGGPDGAGADAALAAIAEALAAG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUSB_ECOL6
Sequence: MRIGQYQLRNRLIAAPMAGITDRPFRTLCYEMGAGLTVSEMMSSNPQVWESDKSRLRMVHIDEPGIRTVQIAGSDPKEMADAARINVESGAQIIDINMGCPAKKVNRKLAGSALLQYPDVVKSILTEVVNAVDVPVTLKIRTGWAPEHRNCEEIAQLAEDCGIQALTIHGRTRACLFNGEAEYDSIRAVKQKVSIPVIANGDITDPLKARAVLDYTGADALMIGRAAQGRPWIFREIQHYLDTGELLPPLPLAEVKRLLCAHVRELHDFYGPAKGYRIARKHVSWYLQEHAPNDQFRRTFNAIEDASEQLEALEAYFENFA
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
What are the official names of this protein?
tRNA-dihydrouridine synthase B.
What is the protein family that this protein belongs to?
Belongs to the Dus family. DusB subfamily.
Protein: OMPD_SALCH
Sequence: MKLKLVAVAVTSLLAAGVVNAAEVYNKDGNKLDLYGKVHAQHYFSDDNGSDGDKTYARLGFKGETQINDQLTGFGQWEYEFKGNRTESQGADKDKTRLAFAGLKFADYGSFDYGRNYGVAYDIGAWTDVLPEFGGDTWTQTDVFMTGRTTGVATYRNTDFFGLVEGLNFAAQYQGKNDRDGAYESNGDGFGLSATYEYEGFGVGAAYAKSDRTNNQVKAASNLNAAGKNAEVWAAGLKYDANNIYLATTYSETLNMTTFGEDAAGDAFIANKTQNFEAVAQYQFDFGLRPSIAYLKSKGKNLGTYGDQDLVEYIDVGATYYFNKNMSTFVDYKINLLDDSDFTKAAKVSTDNIVAVGLNYQF
What is the function of this protein?
Forms pores that allow passive diffusion of small molecules across the outer membrane.
What are the official names of this protein?
Outer membrane porin protein OmpD.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: KATG_PSEE4
Sequence: MANESKCPFHQTAGGGTSNRDWWPDQLNLKILHQHSRKSDPMDPDFDYAKAFKSLDFQALKKDLTALMTDSQDWWPADFGHYGPLFIRMAWHSAGTYRIGDGRGGAGSGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGNKISWADLIVLTGNVALESMGFKTFGFSGGRADVWEPDEDVYWGSEKVWLGGDTRYGKAEAPGKGDLVAEPAKRPQEQGRNLAGERNLENPLAAVQMGLIYVNPEGPEGNPDPVASGKDIRDTFGRMAMNDEETVALIAGGHAFGKTHGAGPADNVGAEPEAAGLEQQGFGWHNTFGTGKGGDTITSGLEVTWTSTPTKWSNEYLNNLFNFEWELTKSPAGAHQWRPKDGKGANTVPDAHDTTKRHAPSMLTSDLALRFDPIYEPIARRFKDNPDQLADAFARAWYKLIHRDMGPLARYLGPEMPNEELLWQDPLPKAGPQPSEADIAAHKAKVLASGLSVAELVSTAWASASTFRGSDKRGGANGARLRLAPQKDWAANQGLDKVLAALEKIRDEGGNKISLADLIVLAGSAAVEKAAKDAGHAISVPFHPGRVDASQAQTDVESFAVLEPLADGFRNFSKARYSVKAEKLLLDKAQLLTLTAPELTVLVGGLRVLGANHGGSKEGVFTDKPGVLTNDFFRNLLDMGVEWKPTSADNEHFEGRDRKTGAVKWTGSRVDLVFGSHAQLRALSEVYGSGDAAAKFVKDFVAAWVKVMELDRFDLK
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: GLSA_PARPJ
Sequence: MNYASILEQIRGDLQPFLGTGKVADYIPELATVPADSFGMAIVTASGEIFRTGEADTRFSIQSISKLFACTLAFQLLGDALWERVGREPSGTAFNSLVQLESERGKPRNPFINAGALVVTDVLCRRFVQAETALVEFMRRLTGETSIDYDSRIAQSELQHAHRNRAMAHFMASFGNMEMPPEVVVDAYCRQCAISMSCVELAKAALFLTNHGVAPVTGERILDTSSAKRLSALMLTCGTYDAAGDFVYRVGLPAKSGVGGGIVAVLPGEMAACVWSPALDSNGNSAAGVLALEWLTTYTGQSIF
What are the official names of this protein?
Glutaminase.
What is the protein family that this protein belongs to?
Belongs to the glutaminase family.
Protein: AZUR_BORPE
Sequence: MFKQVLGGMALMAAFSAPVLAAECSVDIAGTDQMQFDKKAIEVSKSCKQFTVNLKHTGKLPRNVMGHNWVLTKTADMQAVEKDGIAAGLDNQYLKAGDTRVLAHTKVLGGGESDSVTFDVAKLAAGDDYTFFCSFPGHGALMKGTLKLVD
What are the official names of this protein?
Azurin.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLYA_AERPE
Sequence: MKELDLSDPLSMVLKIAELTTRHNVWRLRESINLIASENVMSLTALKAYLSDFMFRYAEGKPFKRYYQGTRYIDELEVLTGELMGSMMGTNLVELRPVSGTIANASVFRVLAEPGDKAVIAPVQAGAHVSHTKFGTLGALGIEQVSMPYDEENMNVDVDKAVKLIEEVKPRFAVLGGSVYIFPHPTREIAEAIHSVGGKLIYDAAHVLGLIMGGAWPNPLERGADAVTGSTHKTFPGPQGGAVFFRDEQLYKKVSKTIFPWWVSNHHLHRIPATAITAVEMKLYGRDYASQVTSNARKLAEALAAEGLKVIGEHLGYTRSHQVVVDVRDLGGGAKCASLLEESNIIVNKNLLPWDPPEAVKDPSGIRIGVQEVTRLGMKHGEMEEIAKLIRKVLIDKEDPKKVAEQVKEFRKQFMKIHYSLDDKDVRIDTIADILSLAQ
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier.  Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HXA3_BOVIN
Sequence: MQKATYYDSSAIYGGYPYQAANGFGYNANQQPYPASTALGADGEYHRPACSLQSPANAGSHPKAHELSEACLRTLSGPPSQPPVLGEPPLAPPPPQAAPPAPPQPPAPPQPPAPTPAAPPPPSSVSPPQNGSSNPTPASAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSGSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGPGSYLNSMHSLVNSVPYEPQSPPPFSKPPQGAYGLPPASYPAPLPSCAPPPPQKRYTAAGAGAGGTPDYDPHAHGLQGNGSYGTPHLQGSPVFVGGSYVEPMSNSGPPLFGLTHLPHTASAAMDYGGAGPLGSGHHHGPGPGEPHPTYTDLTAHHPSQGRIQEAPKLTHL
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A3.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RUVB_PSEPW
Sequence: MIEADRLIAASGRDREEVQDRAIRPLRLDEYIGQPVVREQMALFIQAARGRNESLDHTLIFGPPGLGKTTLANIIAQEMGVSVKSTSGPILERPGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDFQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGMLTNPLRDRFGIVQRLEFYSDKDLATIVSRSANILGLVIEDQGAYEIARRARGTPRIANRLLRRVRDYAEVRGKGQITKAVADLALNLLDVDERGFDHSDRRLLLTMIEKFDGGPVGVDNLAAAISEERHTIEDVLEPYLIQQGYIMRTPRGRVVTRHAYLHFGLNVPGRLGEGADFSEAGDE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: YTFE_ECOSM
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVDVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMEHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTRA_NEIME
Sequence: MFKVKFYIRHAVLLLCGSLIVGCSAIPSSGPSAKKIVSLGQQSEVQIPEVELIDVNHTVAQLLYKAQINQSFTQFGDGYASAGTLNIGDVLDIMIWEAPPAVLFGGGLSSMGSGSAHQTKLPEQLVTARGTVSVPFVGDISVVGKTPGQVQEIIKGRLKKMANQPQVMVRLVQNNAANVSVIRAGNSVRMPLTAAGERVLDAVAAVGGSTANVQDTNVQLTRGNVVRTVALEDLVANPRQNILLRRGDVVTMITNPYTFTSMGAVGRTQEIGFSARGLSLSEAIGRMGGLQDRRSDARGVFVFRYTPLVELPAERQDKWIAQGYGSEAEIPTVYRVNMADAHSLFSMQRFPVKNKDVLYVSNAPLAEVQKFLSFVFSPVTSGANSINNLTN
What is the function of this protein?
Involved in transport of capsular polysaccharides to the cell surface.  May function as a membrane anchor for capsular polysaccharides.  Possible porin properties.
What are the official names of this protein?
Capsule polysaccharide export outer membrane protein CtrA.
What is the protein family that this protein belongs to?
Belongs to the BexD/CtrA/VexA family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: KAD_BURPS
Sequence: MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKTYMDEGKLVPDSLIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLVQRDDDKEETVKKRLDVYEAQTKPLITYYGDWARRGAENGLKAPAYRKISGLGAVEEIRARVFDALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPI18_CHAGB
Sequence: MAPKHQTPHTHAQIHTHPYRTLLTSFAAWKLFLFAIVLGSTLVGDAYDTSGGLLLQGPANGDAATRPAGLGTTLIARLTSWDAIYYVSAARRDYVFEQEWAFGAGLPFVVRTLLQGLEYVGIIDAPGAEGGRALVAEALAGILVANTAHLLSALVLYRLGQVVWRDQTLSLVAALLHVISPAGLFLSAPYSESSFALLSFSGYLLFALGCRAEGSSNSNNSPTRRDLYTISAGVLFGAATVFRSNGLLNGAPFALEVLRHLPAFVRRPTAIDTLRRLAALGVGGAAVAAGSLGPQAAAYLRYCIPSSSSGASDGEENLLLPRPWCQGYLPSIFTFVQQHYWNVGFLRYWTLPNLPLFLLATPMLVILVKSGVDSLRGRHLPGDAKAVDGESGRLLALIRSTAAAQVLLAVLAATTYHVQIITRISSGYPVWHWWLAGRLVQGDKTGSRIVMFMVIYASIQGALFASFLPPA
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 2, GPI mannosyltransferase II, GPI-MT-II, Glycosylphosphatidylinositol-anchor biosynthesis protein 18.
What is the protein family that this protein belongs to?
Belongs to the PIGV family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CRBB3_BOVIN
Sequence: MAEQHSTPEQAAAGKSHGGLGGSYKVIVYEMENFQGKRCELTAECPNLTESLLEKVGSIQVESGPWLAFERRAFRGEQYVLEKGDYPRWDAWSNSHHSDSLLSLRPLHIDGPDHKLHLFENPAFGGRKMEIVDDDVPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRHWNEWDANQPQLQSVRRIRDQKWHKRGVFLSS
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Beta-crystallin B3, Beta-B3 crystallin.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: FENR_CHLL2
Sequence: MTLNKVYYSGGEEIRDLTIVGGGPTGIFAAFQCGMNNITSRIIESMPQLGGQLAALYPEKHIYDVAGFHEVPAAGLVDSLWKQAERYHPEINLGEAVTRYRKLDDGSFETTTKSGKVFLSRALLLAAGLGAFTPRTLPQLGCVDHLEGRSIFYAVKNIRDFAGKKVVIVGGGDSALDWAVGLLDAAEHVTLVHRMHEFQGHGKTAREVDEARDKGVIDVYMDTEVTAIETAEGGMKNVTLLRKNGASVVLEADRLLILIGFRSNLGPLAEWDLELVDNALVVDSHMKTSVDGLYAAGDIAWYPGKLKIIQTGLSDAAMAVRHSLNYIRPGEKIRHTFSSVKMAKQKKNEQ
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: SYD_BUCA5
Sequence: MRTKYCGNIRISHVNKKVKLCGWVHKVRNLGQFIFVDMRDYTGLVQVIFELKNYTIFKKALNLRNEFCIQVFGTVQKREKKNQNIKIRTGEIEILANVLNILNTSKSLPLNFTQENNDDSRLKYRYLDLRSFDILENLKIRNKITYLIRNFMTKKNFLDIETPILTKSTPEGARDYLVPSRNHYGKFYALPQSPQLFKQILMISGIDRYYQIVKCFRDEDLRSDRQPEFTQIDIEVSFMSAKKIRNLVENLIKKLWLEIRNINLKKFPQISFHEAMKKYGSDKPDLRNPIEIIDVSNIFKDKKFISFFNLNPQKNNRIALLCISKGAHLSRKKIDDYTKYVQRFDAKKLFYIKIKECKLGCLGIHSSIKNILDEIILKEIIEKSQSKNGDILFLIADQEHIVNKSLGMLRLKIGIDLNITKKNRWEPLWIVNFPMFDKDIQGNLSSVHHPFTAVKNMDREILKNSPDLAISDSYDLIINGYEIGGGSVRIHDVNMQKQVFDIIGIKKSMQNEKFGFLIEALKYGAPPHAGIALGLDRIVMLLTNSKNIRDVIAFPKTTSATCLMTNSPSTVDNLLLQELAIKHLKK
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_SALAI
Sequence: MQHSKSYRKAAAAIDRSKLYTPAEAVKLAKETTSVKFDATVEVAMRLGVDPRKADQMVRGTVNLPHGTGKTARVIVFAAGAKAEEAVAAGADEVGTDELVARIQGGWLEFDAAIATPDQMAKIGRIARILGPRGLMPNPKTGTVTMNVAKAVSDIKGGKIAFRVDKHSNLHLIIGKASFSEAQLVDNYAAVLDEVLRAKPSAAKGKYLKKVTLTTTMGPGVPVDPNVVKNLQEGSAEG
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PYRB_METMA
Sequence: MMLFKNRHVISMKDFSREEIDYILDIAEKLEPVARGEERSRLLDGKIISLLFFEPSTRTRLSFEVATRRLGGQVLSLGSVEASSVMKGENLADTIRVISKYADLIVLRHPLDGSARMATEFAAVPVINGGDGSVHHPTQTFLDLYTIRRESHLEGLKIAMAGDLKYGRTVHSLCYALSLYGAEMTFVSPPELRMPREIVRELRKKNIRVKESECLEEIIGDIEVLYMTRVQRERFPDPQEYEKVKNKLKITGDLLKSADPELKILHPLPRVNEISPDVDDTPHARYFEQAFYGVPIRMALLALTIGVIE
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.