PharMolix/UniProtQA huggingface dataset:
Protein: SYR_RICCK
Sequence: MNIFNQLKQDIIAASRQLYNNQEIANIVTIETSKDNFNGDLSSNIAMIIAAKENMPPRTVALKFKEILITLPYIASIEIAGPGFINFTIKAESWQIAIKNILQHEGKFFEIDIDKNKYINIEYVSANPTGPMHIGHARGAVYGDVLARILQKVGYNVTKEYYVNDAGSQINDLVSTVLLRYREALGEKITIPVGLYPGEYLIPVGQILVKEYGNKLLVMDEEERFKIVKNFAVEKMLDLNRKDLEELGIKHDLFFSEQSLHDKGKIEEIVKLLTNMGLIYEGTLPAPKGKIHAKWDNRVQKLFKSTKYGDSQDRPIEKADGSWSYFASDLAYAKDKIDRGANHLIYVLGADHSGYVKRIEAIVKALGKEQIKVDVKICQLVNFIENGVPVKMSKRLGNFASVQDVNHEVGKDIIRFMMLTRQNDKPLDFDLVKVKEQSRENPIFYVQYAHVRTVSILSKAMELMPESYSSFEAGIYDLSLLSSEEEIDIIKLLAAWTKTLEVSAKYFEPHRIALYLINLASKFHSIWNFGKENSDYRFVIENNKELTTARLALAKAIQKVIASGFEVIGVEPMNKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_THEM4
Sequence: MRAVVQRVNSANVDVNGKIIGKIKKGLLVLLGVGKNDTESDAEYLVNKILNLRIFDDNKGKMNLSLLDIKGDILIVSQFTLYGDCRRGRRPSYSDSASPEKAKKLYEYFVEKIRKEYNIKVETGEFGAYMKVNLENDGPVTLLLDSKKVF
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF2_MARMS
Sequence: MNLNLTLLGQAISFAIFVWFCMKYVWPPVIAALEERSKKIADGLEAANRASRDLELAQEQASQILRESKENAAEIIEQANKRANQMVDEAKEQVIADGKRLREAAQAEIEQDVMRAKEALRAQVSVLAFAGAEKILGATIDEKAHSEIVEQLAKEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b 2, ATP synthase F(0) sector subunit b 2, ATPase subunit I 2, F-type ATPase subunit b 2, F-ATPase subunit b 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RF1_ERWT9
Sequence: MKPSIVAKLEALQERHEEVEAMLGDAGVIADQERFRALSREYAQLTDVSQCFRQWQQSQEDIETAEMMLSDAEMRDMAQEELQTARAASEELEQQLQVLLLPKDPDDERNCYLEVRAGTGGDEAAIFAGDLFRMYSRYAESRRWKVEVMSANEGEHGGYKEVIAKVVGEGAYGRLKFESGGHRVQRVPETESQGRIHTSACTVAVMPELPEAELPDINPSDLKIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALGVLGSRIRAAEMARRQQEESSTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTIYRLDEAMEGKLDALIEPIVQEYQADQLAALSGQD
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_MYCTO
Sequence: MAAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTVEAPVARRLRESFGGSKPAPAKGTAKSPGKGPDKSLDKALDAAIDMAAGNGKATAAPAKAADSGGAAIVSPTTPAAPEPPTAVPPSPQAPHPGMAPGARPGPVPKPGIRTPRVGNNPFSSAQPADRPIPRPPAPRPGTARPGVPRPGASPGSMPPRPGGAVGGARPPRPGAPRPGGRPGAPGAGRSDAGGGNYRGGGVGAAPGTGFRGRPGGGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFADKIDANPAALVQALFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLSYGEDEGGEEDLQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVAVDLDGSQRLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVPEEFGGDTMFVDISAKQGTNIEALEEAVLLTADAALDLRANPDMEAQGVAIEAHLDRGRGPVATVLVQRGTLRVGDSVVAGDAYGRVRRMVDEHGEDVEVALPSRPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQVDDEVVLRVIDRGVGGITETNVNLASASDAVIIGFNVRAEGKATELASREGVEIRYYSVIYQAIDEIEQALRGLLKPIYEENQLGRAEIRALFRSSKVGLIAGCLVTSGVMRRNAKARLLRDNIVVAENLSIASLRREKDDVTEVRDGFECGLTLGYADIKEGDVIESYELVQKERA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBA_MACSP
Sequence: VLSPADKTNVKAAWDKVGGHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTLAVGHVDDMPHALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1/2, Alpha-1/2-globin, Hemoglobin alpha-1/2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: RL3_SHIDS
Sequence: MIGLVGKKVGMTRIFTEDGVSIPVTVIEVEANRVTQVKDLANDGYRAIQVTTGAKKANRVTKPEAGHFAKAGVEAGRGLWEFRLAEGEEFTVGQSISVELFADVKKVDVTGTSKGKGFAGTVKRWNFRTQDATHGNSLSHRVPGSIGQNQTPGKVFKGKKMAGQMGNERVTVQSLDVVRVDAERNLLLVKGAVPGATGSDLIVKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: KCY_CORGL
Sequence: MPAGGLIVAIDGPSGTGKSTTSRALATRLSAKYLDTGAMYRVATLHVLNQGIDPADSAAVIAATAVLPLSISDDPASTEVLLAGVDVQKDIRGPEVTQNVSAVSAIPEVRENLVALQRALAAKAHRCVVEGRDIGTAVLVDAPIKAFLTASAEVRAQRRFDQDTAAGRDVDFDAVLADVVRRDELDSTRAASPLKPADDAHIVDTSDMTMDQVLDHLIHLVEASAERSNQ
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMPL6_MYCTO
Sequence: MQGISVTGLVKRGWMVRSVFDTIDGIDQLGEQLASVTVTLDKLAAIQPQLVALLPDEIASQQINRELALANYATMSGIYAQTAALIENAAAMGQAFDAAKNDDSFYLPPEAFDNPDFQRGLKLFLSADGKAARMIISHEGDPATPEGISHIDAIKQAAHEAVKGTPMAGAGIYLAGTAATFKDIQDGATYDLLIAGIAALSLILLIMMIITRSLVAALVIVGTVALSLGASFGLSVLVWQHLLGIQLYWIVLALAVILLLAVGSDYNLLLISRFKEEIGAGLNTGIIRAMAGTGGVVTAAGLVFAATMSSFVFSDLRVLGQIGTTIGLGLLFDTLVVRAFMTPSIAVLLGRWFWWPQRVRPRPASRMLRPYGPRPVVRELLLREGNDDPRTQVATHR
What are the official names of this protein?
Probable transport protein MmpL6.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL9_SHEHH
Sequence: MNVILLDKIANLGNLGDQVSVKAGYARNFLLPQGKAVVANAANTEVFEARRADLEAKLAADLAAATQRAEKISALESVVIASKAGDEGKLFGSIGNRDIADAVTAAGVELAKSEVRLPLGAIRTTGEFEVEVQVHTEVKAIVKLSVVAEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: MBIP1_MOUSE
Sequence: MAAAAELSSSSGSERSLEQCSSPLLTREVLCEVFRSLHTLTRQLNLRDDVVKITIDWNRLQSLSASQPALLLTALEQHVLYLQPFLAKLQSLMKENSTATEIRQTEAETKSELRAIHPTEDLQDEGKPKDCDVGDVKKTQNLFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAVFTPYPGFKSHVKVSRVVNTYGPQTRPEGIAGSGHKPTGMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVNFSGKRRKVQPPQQNYSLAELDEKISALKRALLRKSREADSMAAHLP
What is the function of this protein?
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway.  Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
What are the official names of this protein?
MAP3K12-binding inhibitory protein 1, MAPK upstream kinase-binding inhibitory protein, MUK-binding inhibitory protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shows a cytoplasmic localization when co-expressed with MAP3K12.
Protein: VF015_IRV22
Sequence: MDSNALIKRCSSSKNKINGLKVPTVTIKVEEVCLVKSNLKIARKNLKKIEKIYDDLNLINPKQLKGINGLINPLLHTIYYEVWFMFMDDIVHIQKNLIDYFEYANKGEEQPIKNNEFVDKIKMLMKPISVDLSTPSKA
What are the official names of this protein?
Uncharacterized 15.9 kDa protein in MSP 5'region.
What is the protein family that this protein belongs to?
Belongs to the IIV-3 015R family.
Protein: SEPF_STAAE
Sequence: MSHLALKDLFSGFFVIDDEEEVEVPDKQQQVNEAPAKEQSQQTTKQNAIKSVPQKSASRYTTTSEERNNRMSNYSKNNSRNVVTMNNATPNNASQESSKMCLFEPRVFSDTQDIADELKNRRATLVNLQRIDKVSAKRIIDFLSGTVYAIGGDIQRVGTDIFLCTPDNVEVAGSITDHIENMEHSFD
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: VE5A_HPV6C
Sequence: MEVVPVQIAAATTTTLILPVVIAFAVCILSIVLIILISDFLVYTSVLVLTLLLYLLLWLLLTTPLQFFLLTLCVCYFPAFYIHIYIVQTQQ
What are the official names of this protein?
Probable protein E5A.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E5A protein family.
Protein: LEU3_CHRVO
Sequence: MKIAILPGDGIGPEIIAQAERVLEVLRRDGLKIETEHAPLGGAAYDQYGVPYPEATQKLAREADAVLLGAVGGPAYDKLDRPLRPERGLLAIRKDLNLFANLRPAILYPELANASTLKPEVVAGLDIMIVRELTGDIYFGQPRGIAVNELGEREAYNTMRYSESEVRRIAHVAFGIAMKRNRKLCSVDKANVLETTEFWKEIMIEVAKEYPQVELSHMYVDNAAMQLVRNPKQFDVMVTGNIFGDILSDEASMLTGSIGMLPSASLDQNNKGLYEPSHGSAPDIAGQNLANPLATILSAAMMLRYSFGQEAAARRVEDAVKKVLAQGYRTADIYEAGCEKVSCSGMGDAVVAAM
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSK_STRA3
Sequence: MVFMANKKKTKGKKTRRPTKAEIERQRAIQRMITALVLTIILFFGIIRLGIFGITVYNVIRFMVGSLAYLFIAATLIYLYFFKWLRKKDSLVAGFLIASLGLLIEWHAYLFSMPILKDKEILRSTARLIVSDLMQFKITVFAGGGMLGALIYKPIAFLFSNIGAYMIGVLFIILGLFLMSSLEVYDIVEFIRAFKNKVAEKHEQNKKERFAKREMKKAIAEQERIERQKAEEEAYLASVNVDPETGEILEDQAEDNLDDALPPEVSETSTPVFEPEILAYETSPQNDPLPVEPTIYLEDYDSPIPNMRENDEEMVYDLDDDVDDSDIENVDFTPKTTLVYKLPTIDLFAPDKPKNQSKEKDLVRKNIRVLEETFRSFGIDVKVERAEIGPSVTKYEIKPAVGVRVNRISNLSDDLALALAAKDVRIEAPIPGKSLIGIEVPNSEIATVSFRELWEQSDANPENLLEVPLGKAVNGNARSFNLARMPHLLVAGSTGSGKSVAVNGIISSILMKARPDQVKFMMIDPKMVELSVYNDIPHLLIPVVTNPRKASKALQKVVDEMENRYELFSKIGVRNIAGYNTKVEEFNASSEQKQIPLPLIVVIVDELADLMMVASKEVEDAIIRLGQKARAAGIHMILATQRPSVDVISGLIKANVPSRIAFAVSSGTDSRTILDENGAEKLLGRGDMLFKPIDENHPVRLQGSFISDDDVERIVGFIKDQAEADYDDAFDPGEVSETDNGSGGGGGVPESDPLFEEAKGLVLETQKASASMIQRRLSVGFNRATRLMEELEAAGVIGPAEGTKPRKVLMTPTPSE
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region.  Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: CYB_PHAAS
Sequence: MAPNIRKSHPLLKMVNNSLIDLPTPSNISAWWNFGSLLGICLMTQILTGLLLAMHYTADTNLAFSSVSHTCRNVQYGWLIRNLHANGASLFFICIYLHIGRGIYYGSYLYKETWNTGIILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFLIAGLTLIHLTFLHESGSNNPLGITSNCDKIPFHPYFSSKDILGFMLLYFLLTTLALLSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASILILFLSPFLHKSKQRTMTFRPLSQALFWLLVTNLFILTWIGSQPVEHPFIIIGQLASLSYFTILLILLPLTGALENKILNY
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ALLC_SCHPO
Sequence: MSVENVERLSPEQADAFFGQSSVDLISRALGGQVLGCSDDFFASCENLINPADPIRKAGVFVETGAWYDGWETRRHNTAPCDWVIVKLGPSSGRVTGCEIDTTFFNGNHAPEVSVEAAFLPEGNPDAKTNWTPILPKLPCGPTQRHIYRFKEIPQQNFTHVRLCMYPDGGIARFRLYGNVVPVFPADLDARLDLAHMYLGGLVVQCSDQHFGKKDNLLLPGRGVNMGDGWETARSREKGHVDWVIVKLGARGYIDDALIDTNHFKGNYPKEVILEAIDSPDHIPGPDAQWVTILPARKLGPHMEHVFTNLQNNSTPMTHVRMIIIPDGGVKRLRIYGRRAAN
What is the function of this protein?
Utilization of purines as secondary nitrogen sources, when primary sources are limiting.
What are the official names of this protein?
Probable allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: BMCH_HALO1
Sequence: MADALGMIEVRGFVGMVEAADAMVKAAKVELIGYEKTGGGYVTAVVRGDVAAVKAATEAGQRAAERVGEVVAVHVIPRPHVNVDAALPLGRTPGMDKSA
What is the function of this protein?
The only hexameric shell protein in this bacterium, it forms the majority of the bacterial microcompartment (BMC) shell.  Expression of 5 proteins in E. coli (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)) forms a 40 nm artificial BMC with a molecular mass of 6. 5 MDa.  There are 60 BMC-H hexamers per BMC.  The shell facets are 20-30 Angstroms thick (a single hexamer layer), with 1 of BMC-T trimers protruding to the exterior.
What are the official names of this protein?
Bacterial microcompartment protein homohexamer, BMC-H.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: TTCA_ESCF3
Sequence: MSQNQEFSKKEIYNLNKLQKRLRRNVGEAIADFNMIEDGDRIMVCLSGGKDSYTMLEILRNLQQSAPISFSLVAVNLDQKQPGFPEHILPEYLEKLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIQRFADAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGIKHGFEVINGGDLAFDREELPLQPAGWQPEDDENQLDELRLNVVEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPW_CHICK
Sequence: MRRTVPRGTLRKIIKKHKPHLRLAANTDLLVHLSFLLFLHRLAEEARTNAFENKSKIIKPEHTIAAAKVILKKSRG
What is the function of this protein?
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity).  The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity).  Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA.  Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly.  CENPW has a fundamental role in kinetochore assembly and function.  It is one of the inner kinetochore proteins, with most further proteins binding downstream.  Required for normal chromosome organization and normal progress through mitosis.
What are the official names of this protein?
Centromere protein W, CENP-W.
What is the protein family that this protein belongs to?
Belongs to the CENP-W/WIP1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis (PubMed:19070575). Localizes to the inner kinetochore.
Protein: ARMC9_XENLA
Sequence: MGDILAYEADLLGLVKEFLNFGEFQETLECFSKECKIKGKLLPRTSGSSLRESKTLLIQKDLITAFEDGDIKEFFALWQEHIPVETQNTNPVAQKLEFYLQIHFAIFPLKQSQGRIDRVDCEERISHFKTYLETSGAALSQTTEFLPFYALPFVPNPAAHPSFKEIFQESWEAELKMRLEKFLSVILKAASTPKLITLYKESLHNNQEQLQQLQQQLMETEHKARTYKKCFNKMQSDYHNLIGVTADLVDSLEATINGKLITPEYLQSVCTRLFSAQMKQSSAQSIDFTRPGTASSMLRASIAPLKQQEVPLFPSLDYEKLKKDLVFGNDRLKAFILQALRWRLTRSQPGEQRNTVLQAYISNDLLDCQHNEQKNVLILLRSPSEVVRQYTALLIDVCASLGYGRVYLSQNPRLLHSLVEAWKAEEKESIARETVLGILQKLSLRRSMQSAMIKDDLIFWLVRELEDPDHLSDYALQYTIALFMNLCLRTAGRKLCSRDADHVLKVLSDLLGHENHEIRSYVNGALYSILAVPSIREEARSMGMEEILRWYIREGNPDMNCHIEFIIRQLNSEDKFDESVESDDEEEEKDDEEDEDALEADLDKDEIIHAQSGELSGEKLLTTDYLGIMTNSFKVKKRMFAGILQSADEPLQRPVTPSSHRAMNTVRKNSNSPSPLTNTFKSSQANKMSLSSSRPPTRSGSRASSSDSIDSEASRLFSPNSLTDHRGAMSPTSPRILDLGMEKNIVQNSSKAWLPRSPEVQNATSRKTRTPTIAPQFSQSGPQQTSYSSSAGSSTRSRQSTQSYRK
What is the function of this protein?
Involved in ciliogenesis.  It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (By similarity).  Acts as a positive regulator of hedgehog (Hh)signaling (By similarity).
What are the official names of this protein?
LisH domain-containing protein ARMC9.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity). Localizes to the daughter centriole of the primary cilium in RPE1 cells (By similarity).
Protein: PTPRJ_CHICK
Sequence: MRRLPLLPPCPLLLLLLLPAEVRCTTACTDDCSLKNVTEEMGTSSNDELSVNATSGNRRLSEDVSLPGRAMSDQNSVAQPRAVLDLKTEYVGVTSVNLTWTVNDTASDSYTYRIEVRNGSSINNKTSDITDAEITGLIPGTLYTFTVFAVAADGQTAGEGASISLYTKPSPVLDLKAEYVGVTSVNLTWTVNDTASASYTYRIEVTSDSSIDSLTSSVTMAEITGLIPGTLYSFKVFAVAADNRTEADGASISLYTKPSPVLDLKAEYVGVTSVNLTWTVNGTALTAYTYRIEVRNATSIRNETSNINKIEITGLIPGTSYNFKVFATPVNNTTEEEGLSLNLYTKPSPVLRVVTEYVGVTSVNLTWMVDDTASDSYTYRIEVRNGSSINNKTSDITDAEITGLIPGTLYTFTVFAVAADGQTAGEGASISLYTKPSPVLDLKAEYVGVTSVNLTWTVNDTASASYTYRIEVTSDSSIDSLTSNVTMAEITGLIPGTLYNFTVFAVAADNRTEADGAFTSLYTKPTPVTDLKAEHGVTSVSLNWMVNDTASDSYTYRIEVRNGHSVNNKTSNIPETEITGLNPGTLYTFTVFAVAADGETEGEGASISVYTKPRAVLHLKTEYVGVTSVNLTWTVNDTDSASYTYRIEVRNGSSINNKTSDITDAEITGLDPGTLYIFTVFAVAADGQTAGEGASISLYTKPSMVLNLKAEYVTMTSVNLTWMVNDAESASYTYRIEVAHESLINETMSNVTKSIVTYLIPGTSYNFTVFAIAADNQTEGEGASISQNTVPSSVNAFQCEAVANMSYLTLKWNCPYGGYSGFDIEIFNGTWTKKQQSQFCGREGSEEIFKTEPLDYYKTYTVSVTTVSDGLTSLPVQKICKTSITDPPVPNKAPLVKAVSHNSLSVEFPDFESVNGPLKAYAVMIVTEAEGCLPSKSDLDYTYNDFKQKMTATYVTYVIDVEEISSSSHSQNGHNIVDVGKGNTMYGYENGPLIPLHSYRASVAGFTNINFTVANKIMGEQSYVSFSPCSEVVSLPQDPGVIAGAVIGCLLAILAVVAIGGYIFWRRRRKDKRNTEVSFSPIKIKKSKMIKVENFESYFKKQQADSNCGFAEEYEELKSAGVHQPKFAAEIAENRGKNRYNNVLPYDISRVKLSNPSCTTDDYINANYMPGYSSKKAFIAAQGPLPNTIEDFWRMIWEKNIYSIVMLTKCVEQARTKCEQYWPDKQSKSYGDIIVTMVSEVVLPEWTIRDFNVENADTMESHTVRQFHFTSWPDHGVPETTDLLINFRHLVHEYSSQNPIDSPILVHCSAGVGRTGTFIAIDRLIQQIEMENTVDVYGVVYDLRMHRPLMVQTEDQYVFLNQCVMDIIRSQKEKKTDLIYQNTTAMAIYENFTPGPAFGKANGYHA
What is the function of this protein?
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of several substrates (By similarity).  Plays a role in cell adhesion, migration, proliferation and differentiation (By similarity).  May influence the potential of nonsensory supporting cells to either proliferate or differentiate into hair cells (PubMed:10366616).
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase eta, Protein-tyrosine phosphatase eta, R-PTP-eta, HPTP eta, Protein-tyrosine phosphatase receptor type J, R-PTP-J, Supporting-cell antigen.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction.
Protein: Y189_METAR
Sequence: MTKDELKALGWDRCDVVIVSGDAYVDHPSFGVAIIGRVLEKAGFRVGIIAQPDVTDKTSFSRLGEPRLCFCVTSGNVDSMVNNYTANKRLRSDDDYSPGNRPHMRPDRAVTVYCNKIRETYKTIPIITGGLEASLRRFAHYDYWDDKVRQSILADAPADMIVYGMGEKTIVDVVGRLKNGERIADITDIRGTTYKTRKIGDLSDFIELPDFKAVSTDKRAFAEAFKTFYDEQDPYYGHTLVQRHPKTIIVQNPPALPLTTAEMDAIYDLPYTRYPHPSYKEDIPALRTVRFSITSHRGCFGGCAFCAITAHQGRMIQSRSQESILREIRALTKLPEFKGTISDIGGPTADMYMLGCSKRSTQGMCRDKLCLYPEPCPNLNKDHSRLITLLNEVRKVPGVKNVFIGSGIRYDLAMQDEQYLYHICRQNVSGQLKVAPEHVSRNVTDAMCKPSIEAYDKFVSKYREINKELGKEQYIIPYFISAHPGCTLKDAIQLAEYVRDMGYYVEQVQDFTPTPSTLSTCMYYTGYNPYTGQEVYVPKSVEERRMYRALLQYKNPENYDLVKKALISANRKDLIGYGQNCLIKPVRPAIYKKPGRRKP
What are the official names of this protein?
UPF0313 protein UNCMA_01890.
What is the protein family that this protein belongs to?
Belongs to the UPF0313 family.
Protein: VL1_HPV09
Sequence: MSLWLPASGKVYLPPATPVARVQSTDEYVERTNIFYHAISDRLLTVGHPYYDVRSGDGQRIEVPKVSGNQYRAFRISLPDPNRFALADMSVYNPDKERLVWACRGIEIGRGQPLGVGTSGHPLFNKVRDTENSSNYQGTTMDDRQNTSFDPKQVQMFIIGCIPCLGEHWDKAKVCEKDANNQLGLCPPIELRNTVIEDGDMFDIGFGNINNKELSFNKSDVSLDIVDETCKYPDFLTMANDVYGDACFFFARREQCYARHYYVRGGSVGDAVPDGAVNQDHNFFLPAKSDQQQRTIANSTYYPTVSGSLVTSDAQLFNRPFWLQRAQGHNNGILWGNQIFVTVADNTRNTNFTISVSTEAAQTEEYNANNIREYLRHVEEYQISLILQLCKVPLVAEVLSQINAMNSGILEDWQLGFVPTPENAVHDIYRYIDSKATKCPDAVEPTEKEDPFAKYSFWKVDLTERLSLDLDQYPLGRKFLFQAGLQTRKRPIKTSVKTSKNAKRRRT
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.