PharMolix/UniProtQA huggingface dataset:
Protein: U74F2_ARATH
Sequence: MEHKRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQSK
What is the function of this protein?
Glycosyltransferase that glucosylates benzoic acid and derivatives.  Substrate preference is benzoic acid > salicylic acid (SA) > 3-hydroxybenzoic acid > 4-hydroxybenzoic acid.  Catalyzes the formation of both SA 2-O-beta-D-glucoside (SAG) and SA glucose ester (SGE).  Has high affinity for the tryptophan precursor anthranilate.  Catalyzes the formation of anthranilate glucose ester.  Is the major source of this activity in the plant.
What are the official names of this protein?
UDP-glycosyltransferase 74F2, AtSGT1, Salicylic acid glucosyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: RL20_SALAR
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGISYSKFINGLKKASVEIDRKILADIAVFDKVAFSALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CENPS_CHICK
Sequence: MEAAGGEQRELLIQRLRAAVHYTTGCLCQDVAEDKGVLFSKQTVAAISEITFRQCENFARDLEMFARHAKRSTITSEDVKLLARRSNSLLKYITQKSDELASSNMEQKEKKKKKSSAAKGRKTEENETPVTESEDSNMA
What is the function of this protein?
DNA-binding component of the Fanconi anemia (FA) core complex.  Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428).  In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA.  Stabilizes FANCM.  In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks.  In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631).  As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.  DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded.  Does not bind DNA on its own (By similarity).
What are the official names of this protein?
Centromere protein S, CENP-S.
What is the protein family that this protein belongs to?
Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPS is more stably bound at the kinetochore than CENPX. During S phase, rapidly recruited to DNA interstrand cross-links that block replication. Recruited to DNA damage sites about 20 minutes following UV irradiation, reaching a plateau after approximately 40 minutes.
Protein: TRPD_BRUSU
Sequence: MADLKPYIAKAASGEPLSLGDAKAAFDIMMSGQATPSQIGGFLMALRVRGETVPEIAGAVASMRSRMIPVIAPDDAMDIVGTGGDQSGSYNVSSCTAFVVAGAGVPVAKHGNRALSSRSGAADALAALGINIEADADTIGRSISEAGLGFMFAPMHHSAMRHVSPSRVELGTRTIFNLLGPLSNPASVKRQLVGVFAPQWLEPLAHVLKELGSETAWVVYGDGLDEMTTAGTTQVAALENGQIRTFEITPEEVGLRRCSPAELKGGEAAENAKALLGVLEGKDSAYRDIVLLNSGAALVVAGKAENLKDGIAQAVQSIDSGAALAVLQKVIAVSNDKPA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: AROK_CLOB8
Sequence: MKNKVVFIGMPGCGKSTIGRLVSEELKINFIDMDNYIENMTSKTIPELFEHGENYFRDFESLACRELAKEGKAIISSGGGVVKRKENIDILKEESFIIFIDRPLEELLGDVDISKRPLLKEGREKIIKLYEERYELYRLCADKIIRNDREIGNIVNEIKEVILDNLEMN
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIR_THIND
Sequence: MNDLNRLGRVGRWIAGAACLFLASAAHAEPGENLKPVDAMQCFDCHTQIEDMHTVGKHATVNCVHCHDATEHVETASSRRMGERPVTRMDLEACATCHTAQFNSFVEVRHESHPRLEKATPTSRSPMFDKLIAGHGFAFEHAEPRSHAFMLVDHFVVDRAYGGRFQFKNWQKVTDGMGAVRGAWTVLTDADPESSDQRRFLSQTATAANPVCLNCKTQDHILDWAYMGDEHEAAKWSRTSEVVEFARDLNHPLNCFMCHDPHSAGPRVVRDGLINAVVDRGLGTYPHDPVKSEQQGMTKVTFQRGREDFRAIGLLDTADSNVMCAQCHVEYNCNPGYQLSDGSRVGMDDRRANHFFWANVFDYKEAAQEIDFFDFRHATTGAALPKLQHPEAETFWGSVHERNGVACADCHMPKVQLENGKVYTSHSQRTPRDMMGQACLNCHAEWTEDQALYAIDYIKNYTHGKIVKSEYWLAKMIDLFPVAKRAGVSEDVLNQARELHYDAHLYWEWWTAENSVGFHNPDQARESLMTSISKSKEAVSLLNDAIDAQVASR
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process (PubMed:16500161, PubMed:22281743).  Has very low activity toward hydroxylamine (PubMed:16500161).  Has even lower activity toward sulfite (PubMed:16500161, PubMed:22281743).  Sulfite reductase activity is maximal at neutral pH (PubMed:20944237).
What are the official names of this protein?
Cytochrome c-552, Cytochrome c nitrite reductase, TvNiR.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: UPP_NOSS1
Sequence: MTVQLRVYVPPHPLIKHWLAVARDAATPSVLFRSAITELGRWLTYEAAREWLPTEETTVQTPLEICPATVINPQVPVAVVPILRAGLGLLEGAQTVLPLASIYHLGLVRNEETLEASCYLNKLPEKFDPQTRVLITDPMLATGGSIMKAMSELTERGVDPSLVRIVSVVAAPPALQKLNAAYSGLIVYTATIDETVNDQGFIVPGLGDAGDRIFGT
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RUBR_THETC
Sequence: MEKWQCTVCGYIYDPEVGDPTQNIPPGTKFEDLPDDWVCPDCGVGKDQFEKI
What is the function of this protein?
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide.  Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
What are the official names of this protein?
Rubredoxin, Rd.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
Protein: KAD_ALKCK
Sequence: MNLILMGLPGAGKGTQAEKIVNDYGIPHISTGDMFRAAMKNETELGLKAKSFIDAGDLVPDEVTIGIVKERLSEDDCENGFLLDGFPRTIAQAEALEGILSSLGKQLDHVLNIAVPKELLMERLTGRRVSPTTGKTYHIVYNPPKVEGKCDIDGSDLIQRDDDKPETVKRRLEVNEKQTKPLIDFYEAKGYLRQVDGNQDMNTVYADIKAILSEKRA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_CLONN
Sequence: MNFSIPTFVWTIINFLLLLVVLSYFLFKPVNEIIDKRSKDIEGDIEQARIDKDKAEELRIANEEEYKAAKKEGKIIVENYKAKAENVSEEIISDAHKEAEIIIERAKKEIQREREKAEYEIKNKTIELSLELSKKALERSIDEKMHRELIEEFISKVGN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: V17_SPTNK
Sequence: MDLRLQQKILKYQQVRKYYVEDGYTIDEACKKVKINKTTFYNYRKLLKENNLLEIVETNNNINNILSSEVLNKKKIQSKKTTPKKKYN
What are the official names of this protein?
Uncharacterized protein V17.
Protein: MSHC_BRAFD
Sequence: MRSWTSPALAPLPASGLPLRLHDTRTGRITPVVPLTPGTARLYVCGITPYDSTHLGHAATYHAADLMRRALRDSGLAVEMAQNVTDVDDPLLERADRDGVDWRELAASQSALFAEDMEALRVIAPETYRSVSEAMDEIIAVVLALHARGRAYPVEAADAAGPDWYLDLAADGALGDVSGWSEEQMLAVFAERGGDPDREGKRGRFDPLLWSAEREGEPAWDAGVLGRGRPGWHVECVCIAEEGIGLPFDVQAGGSDLIFPHHDLSAAHSVALGRPFAAAYAHSGMVGYQGEKMSKSLGNLVFVHRLVREGTDPMVIRLVLMAHHYRSDWEWTDGELDRAAERLKSYRLAARRGDHRPATVEALRAALRDDLDTVRALEALDAWAEGGSSSGAETDPAAPGDVPTAMDALFGITLQS
What is the function of this protein?
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
What are the official names of this protein?
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, L-Cys:GlcN-Ins ligase, Mycothiol ligase, MSH ligase.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
Protein: RUVA_LACP7
Sequence: MLAFIQGELAEVKENYVVVDNNGMGYEIFIPHTVHSYLPAIGDKVKFHTYLQVREDGMALFGFLNREDLAMFKLLITVNGIGPKGAIGILSAISTDDLRFAVLAEDVKAISKAPGIGTKTASKLILELKDKFKLEDAFEATFQSNQVISTGGKGNNDGIREEAIQALVALGYSATDALKAVKAVEITSNMTSEDVLKFSLRNF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RLF36_ARATH
Sequence: MGISKKTVVQSFALIIIISIVMSTTEANSIGAPAMREDLPKGCAPGSSAGCKMQPANPYKPGCEASQRCRGG
What is the function of this protein?
Cell signaling peptide that may regulate plant stress, growth, and development.  Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
What are the official names of this protein?
Protein RALF-like 36.
What is the protein family that this protein belongs to?
Belongs to the plant rapid alkalinization factor (RALF) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRADD_DANRE
Sequence: MDSIDTKRLNDSNASDRALSGCAVLFLGCSSLEHNFLSLYKDERGKFSVFKVIKLTLSDSVGGLEGYEILKLHDADPYLGVELKFMAMPPCQRFLESYACGSLTQFLSQHASRLLALPDGVEIETQLKAGVHTLDHSLQDIEICLDHIRQSQPVRLRDDEVTQLEQQLQNSYGPPSQPPQELPRNCFLFQKRVFDDRPLTPADQQRFAAHVGRDWKRVGRALQKNCRALKGPAIDNLAYEYEREGLYEQAYQLLGRFIQSEGRSAKLSRLISALEETKMTSMAEIMLGIQPRD
What is the function of this protein?
Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd.
What are the official names of this protein?
Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus.
Protein: IOVO_PAVCR
Sequence: LAAVSVDCSEYPKPACTLEHRPLCGSDNKTYGNKCNFCNAVVESNGTLTLSHFGKC
What are the official names of this protein?
Ovomucoid.
What are the subcellular locations of this protein?
Secreted.
Protein: RL22_SHEPA
Sequence: MEVLAKHRFARTSPQKCRLVADQIRGLPVAKALEILTFSPKKAAVLVKKVLDSAIANAEHNEGADIDELRVGAIMIDEGPTMKRIMPRAKGRADRIIKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: CTTB2_FELCA
Sequence: MATDGASCEPDFSRAPEDAAGATAEAAKKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMSTQLAAAESRQKKLEMEKLQLQAVEQEHQKLAARLEEERGKNKHVVLMLVKECKQLSGKVIEEAQKLEEVMAKLEEEKTKTSALEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLHREEAHTTDLKEEIDKMKKMIEQLKRGNDSKPSLSLPRKTKDRRVVSISVGTEGPVTRSVACQTDLVIESTDHVKKLPLTVPVKPSAGSPLVPANTKGNVCTGAALGRPGIDRQASHGDLIGSSPPTVPPPSANRIEENGPSAGSASSTPPLPNSTAPPTVQTPGIAPQSYSQAPPVHSLHSPCANASLHPGLNPRIQAARFRFQGNANDPDQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGAPPRPGTAPTGDGGTCPPVGRTSLKTPGVARVDRGNPPPIPPKKPGLSQTPSPPHPQLKVIMDSSRASNAGAKVDNKTMASPPSSLPQGNRVINEENLPKSSSPQLPPKPSIDLTVAPAGCAVSALATSQVGAWPAETPGLNQPACSESSLVIPTTIAFCSSINTVSASSCRTGASDSLLVTASGWSPSLTPLLMSGGPAPLAGRPTLLQQAATQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLNAGAQVNAADTNGFTPLCAAAAQGHFKCVELLISYDANINHAADEGQTPLYLACKNGSKECIQLLLEAGTDRSVKTRDGWTPVHAAVDTGNVDSLKLLMYHRAPACRNSLHEEESESVVFDLDQGEESPEGTSKPVVPAELINHADREGWTAAHIAASKGFKNCLEILCMHGGLEPERKDKCHRTAHDVATDDCKHLLENLNALKIPLRISVGEIEPGSYGSDDFECENTICALNIRKQTSWDDFSKAVSQALTNHFQAISSDGWWSLEDVTFNNTTDSSIGLGTSSVRSIMLGNVPWSAGQSFTQSPWDFMKKNKAERVTVLLSGPQEGCLSSVTYASMIPLQMLQNYLRLVEQYHNVIFHGPEGSLQDYIAHQLALCMKHRQMAAGFTCEIVRAEVDAGFSKEQLIDLFINSACLIPVKQSPVNKKIIIILENLEKSSLSELLGDFLAPLENRSTESPWTFQKGNGTSECYYFHENCFLMGTIAKACLQGSDLLVQQHFRWVQLRWDGEPMQGLLQRFLRRKVVNKFRGQVPSPCDPVCKTVDWVLAVWRQLNSCLARLGTPEALLGPKYFLSCPVVPGHAQATVKWMAKLWNAIIAPRVQEAILSRASVKRQPGLGLATAKKHPSQGQQAVVKAALSILLNKAVLHGCPLPRAELDQHAADFRGGSFPLSIVSSYHSYSKKKGESGAWRKVSTSPRKKSGRFSPPSWNKPGLSEEGIRIKAVSQQNCNRNASLSKQKSLENDLSLTLNLDQRLSLGSDDEADLVKELQSMCSSRSESDISKIADSRDDLRRFDGSRNNPAFSTVNPRMPVSPKEVSPLSSHETTECSNSQSKIELGVSRVKSFLPVPRSKVTQCSQNTKRSSSSSNTRQIEINNNTKEEIWNFHQNEQVEKPNQ
What is the function of this protein?
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
What are the official names of this protein?
Cortactin-binding protein 2, CortBP2.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex. Cell projection, dendritic spine. Note=Remains associated with dendritic spines even after glutamate stimulation.
Protein: SET1_SCHPO
Sequence: MDFNTSTRSKSQPVQRNNYKVLYDPELGIKENLGRKIIYRFNGVSKPPLVVRDPRLKNPIYARGIPKSGRPFLKSLQTINYDYNENSLGPEPPTQVFVSNISPLVTSEQLRYHFKSFGEVFDLDLKLNPYTGTSLGLCCISFDKRSSISVAAHSAKIAVQQANGLRFSGKPLSVVLDRDGSLCEEAFKKALNAVEKQFQEETLQKQRFEREDESSRQKLSAAMNEDIPPWRQPSKNSQTLSNGDLQHSKVQNVDQKSGFLTSSETDVPKNINDYIYLLIDDRFVPPDRVYYTDIKHHFRKFLYEKIYMNKDGFYITFNNYREASNCYRALDRTYVQNCRIKLKFHDIPSRTKEDGKKSAVRRVVLPPEEAYAEATSVVLRDLEAALLRDVKSKIIGPAIFKYLHSMPKPSVKEELQENLLVSSTSVPDVPLKIESTVGKLPSLPKFKKRVDSSKMNLSAGSKTKSKLQRRRRRRHEARPLHYQLNQMYNSSASEAESDQELLLSSGDERVERGKIGSIKSVKSDEATPVFSDTSDENDKFHRFRTKSKISKKKYEKMEVDYTSSSETESDASILSPSAAIPKSGSAIKDELISPKKEIDEVLALAPKWRINEFDETGSVYYGALPYNYPEDDVLLDLDGLQYLVKNDEDYSYLQEALKDEPLMDINDPNFWAYERKSCKFKNGDVKYGDTAILPEPKGYFRSNTSGSAKSEGYYIIPTTEKSLYLPLRNRSTIDTISHSTSRITSRMNRVNNRRLAAGVEKSQLPAEADLLRFNALKARKKQLHFGPSRIHTLGLFAMENIDKNDMVIEYIGEIIRQRVADNREKNYVREGIGDSYLFRIDEDVIVDATKKGNIARFINHSCAPNCIARIIRVEGKRKIVIYADRDIMHGEELTYDYKFPEEADKIPCLCGAPTCRGYLN
What is the function of this protein?
Catalytic component of the Set1 complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3.  Methylation promotes maintenance of active chromatin states at euchromatic chromosomal domains and is present throughout the cell cycle.  Plays a role in telomere maintenance and DNA repair in an ATM kinase rad3-dependent pathway.  Required for efficient telomeric and centromeric silencing.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-4 specific, COMPASS component set1, Lysine N-methyltransferase 2, SET domain-containing protein 1, Set1 complex component set1, Set1C component set1, Spset1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MNMA1_THEP3
Sequence: MKKNNRVVVGMSGGVDSSVSAYLLKEQGFDVIGVTMQIWQDKDEEAVRVEGGCCSLSAVNDARRVANKIGIKYYVMNFKDVFKEKVIDYFVDEYLKGRTPNPCIACNKYIKFEELLKRAWMIDAYYVATGHYAIKEYDEERGRYLLKKSVDTSKDQTYVLYNLTQTQLEHILFPLGKYKKDEVRELAKNLGLPVASKPDSQEICFVTDNDYGKFIRENAKEEIKPGEFRDTRGRFLGYHKGIIHYTIGQRKGLGISVGKPLYVVDIDAENNVVVLGYGDEVFGDELISYNNNFISIDKLEREMRVKAKIRYNAKEQDAVIRPLEDGKVFVKFDNPQRAITPGQSVVFYEGDIVVGGGTIERKVR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA 1.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANX11_MOUSE
Sequence: MSYPGYPPPAGGYPPAAPGGGPWGGAGYPPPSMPPIGLDNVANYAGQFNQDYLSGMAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPPAQQPVPPYGMYPPPGGNPPPGMPSYPAYPGAPVPGQPMPPTGQQPPGAYPGQPPMTYPGQSPMPPPGQQPVPSYPGYSGSSTITPAVPPAQFGNRGTITAASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDVYEIKEAIKGAGTDEACLIEIFASRSNEHIRELSRAYKTEFQKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSELDLLDIRAEYKRMYGKSLYHDITGDTSGDYRKILLKICGGND
What is the function of this protein?
Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity).  Binds specifically to calcyclin in a calcium-dependent manner.
What are the official names of this protein?
Annexin A11, Annexin XI, Annexin-11, Calcyclin-associated annexin 50, CAP-50.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
What are the subcellular locations of this protein?
Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.
Protein: S39A9_PONAB
Sequence: MDDFISISLLSLAMLVGCYVAGIIPLAVNFSEDRLKLVTVLGAGLLCGTALAVIVPEGVHALYEDILEDPEAARSSNSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPVMSMVTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGIGHSHKLDATGGRGLSRLEVAALVLGCLIPLILSVGHQH
What is the function of this protein?
Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis.  Participates in the zinc ions efflux out of the secretory compartments.  Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (By similarity).  Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity).  This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity).  Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription.  Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity).
What are the official names of this protein?
Zinc transporter ZIP9, Solute carrier family 39 member 9, Zrt- and Irt-like protein 9, ZIP-9.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRPC_BUCDN
Sequence: MKETILEKIVKNKYEWIKFRKKKQPLITFKNHINTKTRNFYNSLKEKNPVFILECKKKSPSLGIIKKNFNLIDIAKIYNKYASAISVLTDEKYFDGKLEFINIVRERVSQPILCKDFFIDPFQIYLARYYNADAILLMLSILDDFQYQKLSKIAKELNMGILTEVNNTSELKRAIKLNANIIGINNRNLHDLSINLNRTRILSSLIPKNIIIISESGITKYKQIRYLSQFVNGFLIGSHLMSEKQLEIGVRSLILGENKICGLTRSCDIEIAEKYGAVYGGLIFAPSSLRKISKNTAKKIIFNNTLRNVGVFQNENIEIVKNIAEELNLYAVQLHGQEDQKYVKKLRQTLSINIQIWKAFSIDSKIPDLNWDHIHKYVLDSQFGGSNKCFNWSILKHQILENVILAGGINSNNCIKASKLNCSGLDLNSGIEVSPGIKDHKKIKSVFQKLRYY
What is the function of this protein?
Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway.  The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).
What are the official names of this protein?
Tryptophan biosynthesis protein TrpCF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the TrpF family.
Protein: PAQRB_MOUSE
Sequence: MRFRNRFQRFMNHRAPANGRYKPTCYEHAANCYTHAFLIVPAIVGSALLHRLSDDCWEKITAWIYGMGLCALFIVSTVFHIVSWKKSHLRTVEHCFHMCDRMVIYFFIAASYAPWLNLRELGPLASHMRWFIWLMAAGGTIYVFLYHEKYKVVELFFYLTMGFSPALVVTSMNNTDGLQELACGGLIYCLGVVFFKSDGIIPFAHAIWHLFVATAAAVHYYAIWKYLYRSPTDFIRHL
What is the function of this protein?
Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.
What are the official names of this protein?
Monocyte to macrophage differentiation factor, Progestin and adipoQ receptor family member 11, Progestin and adipoQ receptor family member XI.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein.
Protein: GUX1A_NEUCR
Sequence: MLAKFAALAALVASANAQAVCSLTAETHPSLNWSKCTSSGCTNVAGSITVDANWRWTHITSGSTNCYSGNEWDTSLCSTNTDCATKCCVDGAEYSSTYGIQTSGNSLSLQFVTKGSYSTNIGSRTYLMNGADAYQGFELLGNEFTFDVDVSGTGCGLNGALYFVSMDLDGGKAKYTNNKAGAKYGTGYCDAQCPRDLKYINGIANVEGWTPSTNDANAGIGDHGTCCSEMDIWEANKVSTAFTPHPCTTIEQHMCEGDSCGGTYSDDRYGGTCDADGCDFNSYRMGNTTFYGEGKTVDTSSKFTVVTQFIKDSAGDLAEIKRFYVQNGKVIENSQSNVDGVSGNSITQSFCNAQKTAFGDIDDFNKKGGLKQMGKALAKPMVLVMSIWDDHAANMLWLDSTYPVEGGPGAYRGECPTTSGVPAEVEANAPNSKVIFSNIKFGPIGSTFSGGSSGTPPSNPSSSVKPVTSTAKPSSTSTASNPSGTGAAHWAQCGGIGFSGPTTCQSPYTCQKINDYYSQCV
What are the official names of this protein?
Exoglucanase 1, 1,4-beta-cellobiohydrolase 1, Exocellobiohydrolase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.