PharMolix/UniProtQA huggingface dataset:
Protein: ELOA1_RAT
Sequence: MAAESALQVVEKLQARLAANPDPKKLLKYLKKLSVLPITVDILVETGVGKTVNSFRKHEQVGNFARDLVAQWKKLVPVERNNEAEDQDFEKSNSRKRPRDVPQQEEEAEGNYQESWQASGSQPYSPEHRQKKHRKLPELERPHKVAHGHERRDERKRCHKVSPPYSSDPESSDYGHVQSPPPSSPHQMYTDLSRSPEMDQEPIVSHPKPGKVHSNTFQDRLGVSHLGEHQGKGAVSQNKPHKSSHKEKRPVDARGDEKSSVMGREKSHKASSKEESRRLLSEDSAKEKLPSSVVKKEKDREGNSLKKKLSPALDVASDNHFKKPKHKDSEKIKSDKNKQSVDSVDSGRGTGDPLPRAKDKVPNNLKAQEGKVRTNSDRKSPGSLPKVEEMDMDDEFEQPTMSFESYLSYDQPRKKKKKVVKTSGTALGEKGLKKKDSKSTSKNLNSAQKLPKANENKSDKLQPAGAEPTRPRKVPTDVLPALPDIPLPAIQTNYRPLPSLELISSFQPKRKAFSSPQEEEEAGFTGRRMNSKMQVYSGSKCAYLPKMMTLHQQCIRVLKNNIDSIFEVGGVPYSVLEPVLERCTPDQLYRIEECNHVLIEETDQLWKVHCHRDFKEERPEEYESWREMYLRLQDAREQRLRLLTNNIRSAHANKPKGRQAKMAFVNSVAKPPRDVRRRQEKFGTGGAAVPEKVRIKPAPYTTGSSHVPASNSSSSFHSSPEELAYEGPSTSSAHLAPVASSSVSYDPRKPAVKKIAPMMAKTIKAFKNRFSRR
What is the function of this protein?
As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A.
What are the official names of this protein?
Elongin-A, EloA, Elongin 110 kDa subunit, RNA polymerase II transcription factor SIII subunit A1, SIII p110, Transcription elongation factor B polypeptide 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYGB_PSESM
Sequence: MSAQDFLVELGTEELPPKTLVSLADAFLAGIEKGLAGAGLTYSAKQVYAAPRRLAVLITALATQQPDRSVNLDGPPRQAAFDADGNPTQAALGFAKKCGVDLSEIDQSGPKLRYSQTILGKPTTSLLPTIVEDSLNDLPIAKRMRWGARKEEFVRPTQWLVMLFGDQVVDCTILAQSAGRHSRGHRFHHPEDVRISSPAGYLSDLRAANVLADFNERRQIISKRVEELASQQEGTAIVPPSLLDEVAGLVEWPVPLVCSFEERFLDVPQEALITTMQDNQKYFCLLDADGKLLPRFITVANIESKDPAQIIAGNEKVVRPRLTDAEFFFKQDKKQKLETFNDRLKNVVFQAQLGSVFDKAERVSKLAAYIAPRIGGDAQRAARAGLLSKCDLSSEMVGEFPEMQGIAGYYYAKADGEAEDVALALNEQYMPRGAGAELPTTLTGAAVAIADKLDTLVGIFGIGMLPTGSKDPYALRRAALGILRILIEKKLDLNLVETVKFAVTQFGAKVKPAGLAEQVLEFIFDRLRARYEDEGVEVAVYLSVRALQPASALDFDQRVQAVQAFRKLPQAAALAAVNKRVSNLLSKAEGSIAQTVEPKYFDNANEFSLYSAIQQADHAVQPMAAERQYSESLARLAMLREPVDAFFEAVMVNAEDANVRANRYALLARLRGLFLGVADISLLG
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_CLOPS
Sequence: MKEFDTIAAIATALGEGGIAIIRVSGNKALEIVNKIFRGINGKDLLDIKPYTMRYGHMIDENNEIIDEVIVSFMKGPRSFTAEDTVEINCHGGIVATNKVLQNVIKAGARLAEPGEFTKRAFLNGRIDLSQAEAVMDIITAKTELSMKSAMTQSQGRLSTEINNLRKEALDILALIEYAVDFTEDDEEPDETIPVKVKEDVITLRGKVNNLIDTADEGKLIRDGLSMVIVGKPNVGKSSLLNALLNENRAIVTDIAGTTRDVIEEYINLDGIPVRLVDTAGIRETEDVVEKIGVEKSKEKINEADLVILMLDTSRELDEEDKEIIDYIKDRKYIVLLNKVDLDRKLSSEIVDNLENKIELSAKTGFGIDDLKSKIKDLFFNGSIDAESVMVTNTRHKEALYRASENLDGALNGLNNNEFLDLVSIYVTSALRALGEITGAELEEDLVNKIFAEFCCGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EBPS_STAAC
Sequence: MSNNFKDDFEKNRQSIDTNSHQDHTEDVEKDQSELEHQDTIENTEQQFPPRNAQRRKRRRDLATNHNKQVHNESQTSEDNVQNEAGTIDDRQVESSHSTESQEPSHQDSTPQHEEEYYNKNAFAMDKSHPEPIEDNDKHDTIKNAENNTEHSTVSDKSEAEQSQQPKPYFTTGANQSETSKNEHDNDSVKQDQDEPKEHHNGKKAAAIGAGTAGVAGAAGAMAASKAKKHSNDAQNKSNSGKANNSTEDKASQDKSKDHHNGKKGAAIGAGTAGLAGGAASKSASAASKPHASNNASQNHDEHDNHDRDKERKKGGMAKVLLPLIAAVLIIGALAIFGGMALNNHNNGTKENKIANTNKNNADESKDKDTSKDASKDKSKSTDSDKSKEDQDKATKDESDNDQNNANQANNQAQNNQNQQQANQNQQQQQQRQGGGQRHTVNGQENLYRIAIQYYGSGSPENVEKIRRANGLSGNNIRNGQQIVIP
What is the function of this protein?
Promotes binding of soluble elastin peptides and tropoelastin to S. aureus cells although it is not able to promote bacterial adherence to immobilized elastin and, therefore, is not a microbial surface component recognizing adhesive matrix molecule (MSCRAMM).
What are the official names of this protein?
Elastin-binding protein EbpS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THF1_NOSS1
Sequence: MELLRTVSDTKRTFYALHTRPINTIYRRVVEELMVEMHLLSVNVDFSYNPIYALGVVTTFDRFMEGYQPERDKESIFSAICQAVEQEPQRYRQDAERLQAVAQSLPVNDLVAWLSQANHLQQDADLQAQLQAIANNSNFKYSRLFAIGLFTLLEQSNPDLVKDEKQRTEALKSIAAGLHLSDDKFSKDLELYRSNLDKMTQALAVMADMLTADRKKREQRQQQASTPVAPPNE
What is the function of this protein?
May be involved in photosynthetic membrane biogenesis.
What are the official names of this protein?
Protein Thf1.
What is the protein family that this protein belongs to?
Belongs to the THF1 family.
Protein: IHFA_BRUAB
Sequence: MGGKTVTRADLAEAVYRKVGLSRTESAALVEMILDEVCDAIVNGETVKLSSFATFQVRDKNERIGRNPKTGEEVPILPRRVMTFKASNVLKQRILQEHQKRQGKTSK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PYRD_STRGG
Sequence: MYKIFFRLVFKRMDPERAHYAAFRWIRLAARIPVLRTFVAAALAPRHKELRTEALGLRMHGPFGLAAGFDKNAIAIDGMAMLGFDHVEIGTVTGEPQPGNPKKRLFRLVADRALINRMGFNNEGSAAVAARLAARNPVFRTTVGVNIGKTKVVPEDEAAADYVKSTERLAAHADYLVVNVSSPNTPGLRNLQATESLRPLLTAVREAADRTVTTRRVPLLVKIAPDLADEDVDAVADLAVELGLDGVIATNTTVAREGLGLKSHPDLVGEAGGLSGAPLKDRSLEVLSRLYARVGDRITLVGVGGVENAEDAWQRILAGATLVQGYSAFIYEGPAYARAIHQGLAARLAASPYATLAEAVGAETRKQAAA
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MQO_ECO7I
Sequence: MKKVTAMLFSMAVGLNAVSMAAKAKASEEQETDVLLIGGGIMSATLGTYLRELEPEWSMTMVERLEGVAQESSNGWNNAGTGHSALMELNYTPQNADGSISIEKAVAINEAFQISRQFWAHQVERGVLRTPRSFINTVPHMSFVWGEDNVNFLRARYAALQQSSLFRGMRYSEDHAQIKEWAPLVMEGRDPQQKVAATRTEIGTDVNYGEITRQLIASLQKKSNFSLQLSSEVRALKRNDDNTWTVTVADLKNGTAQNIRAKFVFIGAGGAALKLLQESGIPEAKDYAGFPVGGQFLVSENPDVVNHHLAKVYGKASVGAPPMSVPHIDTRVLDGKRVVLFGPFATFSTKFLKNGSLWDLMSSTTTSNVMPMMHVGLDNFDLVKYLVSQVMLSEEDRFEALKEYYPQAKKEDWRLWQAGQRVQIIKRDAEKGGVLRLGTEVVSDQQGTIAALLGASPGASTAAPIMLNLLEKVFGDRVSSPQWQATLKAIVPSYGRKLNGDVAATERELQYTSEVLGLKYDKPQAADSTPKPQLKPQPVQKEVADIAL
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: CADC_LISIN
Sequence: MNNEICEITCIHEDKVNRAKSKLANFDTPSVSGFFKILSDENRLKIVHALVHEDELCVCDIANIIDASVATTSHHLNSLKKLGVVDSHKDGKLVYYFIKNIKILNLMELGVNFKEEVLA
What is the function of this protein?
Metal-binding repressor for the cad operon.  Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead.  Metal binding causes the repressor to dissociate from the DNA (By similarity).
What are the official names of this protein?
Cadmium resistance transcriptional regulatory protein CadC, Cadmium efflux system accessory protein.
Protein: MNMG_HAEDU
Sequence: MIYPEHYDVIVVGGGHAGTEAALAPARMGLKTLLLTHNVDTLGQMSCNPAIGGIGKGHLVKEIDAMGGLMAIATDHAGIQFRTLNSSKGPAVRATRAQADRVLYRQSVRTALENQQNLAIFQQEVVDILVENHRASGVVTKMGLTFKAKTVILTAGTFLAGKIHIGLDNYAGGRAGDPAATRLAERLRDLNLRVDRLKTGTPPRLDARTINFEVLAKQPGDEVLPVMSFMGEVGQHPRQIPCYITHTNHQTHDIIRANLDRSPMYTGIIEGIGPRYCPSIEDKVMRFGDRNGHQIYLEPEGLTTIEVYPNGISTSLPFDVQMAIVNSMKGLENTRIIKAGYAIEYDYFDPRDLKPTLETKAIEGLFFAGQINGTTGYEEAAAQGLLAGINAALQVQAKPSWFPTRDVAYTGVLVDDLCTLGTKEPYRVFTSRAEYRLLLREDNADIRLTPIAHQLGLIDEARWQRFNQKMENIERERERLKQIWIHPQSAYVDAVNQLVNSPLTREVNGEDLLRRPEINYAKLTEIAAFAPALDDRQAAEQVEIAIKYQGYIEHQYNEIERHKRHENTLIPAEFDYNKVDSLSNEVRAKLMQHRPISIGQASRISGITPAAISILLVNLKKQGMLKRGEI
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPR_SALSV
Sequence: MTQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKTELGAGIATITRGSNSLKSAPVELRHWLENVLLKNA
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THRB_BOVIN
Sequence: MARVRGPRLPGCLALAALFSLVHSQHVFLAHQQASSLLQRARRANKGFLEEVRKGNLERECLEEPCSREEAFEALESLSATDAFWAKYTACESARNPREKLNECLEGNCAEGVGMNYRGNVSVTRSGIECQLWRSRYPHKPEINSTTHPGADLRENFCRNPDGSITGPWCYTTSPTLRREECSVPVCGQDRVTVEVIPRSGGSTTSQSPLLETCVPDRGREYRGRLAVTTSGSRCLAWSSEQAKALSKDQDFNPAVPLAENFCRNPDGDEEGAWCYVADQPGDFEYCDLNYCEEPVDGDLGDRLGEDPDPDAAIEGRTSEDHFQPFFNEKTFGAGEADCGLRPLFEKKQVQDQTEKELFESYIEGRIVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISMLDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCLPDKQTAAKLLHAGFKGRVTGWGNRRETWTTSVAEVQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDRLGS
What is the function of this protein?
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.  Functions in blood homeostasis, inflammation and wound healing (By similarity).
What are the official names of this protein?
Prothrombin, Coagulation factor II.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: SPIKE_IBV6
Sequence: MLERSLLLATLLSALCSANLFGNNSYVYYYQSAFRPSDGWHLHGGAYEVVNVSTESSNAGTTGCTAGAIYWSKNFSAASVAMTAPQNGMSWSTEQFCTAHCNFTDFVVFVTHCYKSGHGSCPLTGLIPQNHIRISAMKNSSLFYNLTVAVTKYPRFKSLQCVNNMTSVYLNGDLVFTSNETKDVSAAGVHFKAGGPITYKVMREVKALAYFVNGTAQDVILCDGSPTGLLACQYNTGNFSDGFYPFTNSSLVKEKFIVYRESSVNTTLELTNFTFSNVSNATPNTGGVQTIQLYQTITAQSGYYNLNFSFLSSFIYKASDYMYGSYHPSCKFRLETINNGLWFNSLSVSLGYGPIQGGCKQSVFANRATCCYAYSYNGPSLCKGVYRGELTKSFECGLLVFVTKTDGSRIQTRNEPFTLTQHNYNNITLDRCVEYNIYGRVGQGFITNVTNYAINYNYLADGGMAILDTSGAIDIFVVQGEYGLNYYKVNPCEDVNQQFVVSGGKLVGILTSRNETGSQPLENQFYIKIINGTRRSRRSITGNVTNCPYVTYGKFCIKPDGSISTIVPKELEHFVAPLLNVTENVLIPDSFNLTVTDEYIQTRMDKVQINCLQYVCGNSLECRKLFQQYGPVCDNILSVVNSVGQKEDMELLYFYSSTKPSGFNTPVLSNVSTGEFNISLLLTPPSSASGRSFIEDLLFTSVESVGLPTDDAYKKCTAGPLGFLKDLACAREYNGLLVLPPIITAEMQTLYTSSLVASMAFGGITSAGAIPFATQLQARINHLGITQSLLFKNQEKIAASFNKAIGHMQEGFRSTSLALQQIQDVVNKQSSILTETMASLNKNFGAISSVLQDIYQQLDSIQADAQVDRIITGRLSSLSVLASAKQAEYYRVSQQRELATQKINECVKSQSIRYSFCGNGRHVLTIPQNAPNGIVFIHFTYTPESFVNVTAIVGFCVNPANASQYAIVPANGRGIFIQVNGSYYITARDMYMPRDITAGDIVTLTSCQANYVSVNKTVITTFVDNDDFDFDDELSKWWNDTKHELPDFDEFNYTVPILDIGSEIDRIQGVIQGLNDSLIDLETLSILKTYIKWPWYVWLAIAFLTIIFILVLCWIFFMTGCCGCCCGCFGIIPLMSKCGKKSSYYTTFDNDVVYEQYRPKKSV
What is the function of this protein?
Acts as a viral fusion peptide after S2 cleavage occurring upon virus endocytosis.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the gammacoronaviruses spike protein family.
What are the subcellular locations of this protein?
[Spike protein S2]: Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers may be transported to the plasma membrane, where they may mediate cell-cell fusion. SUBCELLULAR LOCATION: [Spike protein S1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Some S oligomers may be transported to the plasma membrane, where they may mediate cell-cell fusion. S1 is not anchored to the viral envelope, but associates with the extravirion surface through its binding to S2.
Protein: CCRL2_MACMU
Sequence: MANYTLAPEDEYDVLIEGELESDEAEQCDRYDTWALSAQLVPSLCSAVFVVGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTLQRYLVFLHKGNFFSVRRRVPCGIVTSAVAWVTAILATVPEFAVYKPQMEDPKYKCAFSRTPFLPADETFWKHFLTLKMNVSVLVFPLFIFTFLYVQMRKTLRFGEQRYSLFKLVFAIMVVFLLMWAPYNIALFLSTFKEHFSLSDCKSNYNLDKSVLITKLIATTHCCVNPLLYVFLDGTFRKYLCRFFHRRSNTPRQPRRRFAQGTSREEPDRSTEV
What is the function of this protein?
Receptor for CCL19 and chemerin/RARRES2.  Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor.  Plays a critical role for the development of Th2 responses (By similarity).
What are the official names of this protein?
C-C chemokine receptor-like 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YAJC_RICFE
Sequence: MSANTQDNQANNNDTIEIQETEVVPVETNSLQSGLTSLTPMVLIFAVFYFLLLRPQEKRRKEREKLVSEVKKGEEVLTNSGIYGIVTKVSENDNNIEIEIAKDVRIKALKSAIVDITSRTKEVAVKKENNKKDKKVSGAKSS
What is the function of this protein?
The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes.  While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
What are the official names of this protein?
Sec translocon accessory complex subunit YajC.
What is the protein family that this protein belongs to?
Belongs to the YajC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MATK_NEPMI
Sequence: MEELRGYLELDRSWQRDFLYTLILQEYIYSLAHDHGFNRTIFLENAGYEKKYSFLIVKRLITRMYQQNHLILSANDSNQNEFWGQKKNLYYQVISEGFAFIVEIPFSLQLLFSLEGKEIVKSRNLRSIHSIFPFLEDKFSHLNYVLDILIPHPVHLEILVQTIRYWTKDASSLHLLRFFLYEXRNWNSRISIKQYISFFSNRNQRLFLFLYNSHVCEYESIFIFLRNQPSHLRSTFSGAFLERIHFYEKMEHLVKVFTKNFQVILWFFKDTFMHYVRYQGKSFVASKGTSLLMIKWKYYLVNFWQCYFSVWSQPRRIYINQLSNHSLDFMGFLSSVRLNPSVVRIQMFEKSFIIDNAINTFDTLVPNIPMIGSFAKEKFCNIFGHPISKPVWADLSDSDIIDRFGRICRSLFHYYSGSSRKKSLYRIKYILRISCARTLARKHKSTVRTFLKRLGSEFLEEFFMEEEKVLSLILPRDSYTSQRFYRGRIWYLDIFCIHDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RUVC_ECOLC
Sequence: MAIILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: YCFP_ECO27
Sequence: MIIYLHGFDSNSPGNHEKVLQLQFIDPDVRLISYSTRHPKHDMQHLLKEVDKMLQLNVDERPLICGVGLGGYWAERIGFLCDIRQVIFNPNLFPYENMEGKIDRPEEYADIATKCVTNFREKNRDRCLVILSRNDEALNSQRTSEELHHYYEIVWDEEQTHKFKNISPHLQRIKAFKTLG
What are the official names of this protein?
UPF0227 protein YcfP.
What is the protein family that this protein belongs to?
Belongs to the UPF0227 family.
Protein: RK2_CHLRE
Sequence: MGIRFLQAYTPGTRNRSVSDFSELTDKNSTPEKALTVSLHRAKGRNNRGIITCRHRGGGHKRLYRQIDFRRDKIGVTAKVVRIEYDPNRNARIALLRYEDGEKRYIIHPRGLNIGDIIQSDLNAPILIGNSLPLRNIPLGAEVHNVEFQPGSGGQLARSAGAMVEILAKEGNFVTIRLPSKEIRLVSKNCWATVGQVGNIEAYNLTIGKAGRTRWLGKRPTVRGSVMNPVDHPHGGGEGRAPIGRSRPVTPWGRPALGQLTRKPKKYSNTLIVKKRKK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: P22_ASFP4
Sequence: MFNIKMTISVLLIALIVLLIIILVVFLYYKKQQPPKKVCKVDKDCGSGEHCVRGSCSSLSCLDAVKTDKRNIKIDSKISSCEFTPNFYRFTDTAADEQQEFGKTRRPIKITPSPSESHSPQEVCERYCSWGTDDCTGWEYEGNEKEGTCYIYNNPHHPVLKYGKDHVIALPRNHKHA
What are the official names of this protein?
Inner membrane protein p22.
What is the protein family that this protein belongs to?
Belongs to the asfivirus inner membrane protein p22 family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Part of the virion inner membrane.
Protein: RSMH_ANOFW
Sequence: MTSLFHHVTVLLKETVDGLNIKKDGTYVDCTLGGAGHSEYLLSQLSPEGRLFAFDQDDIAIRHAQQRLERYRGQFTIIKSNFRYLKQQLALYGVHEVDGILFDLGVSSPQLDMPERGFSYQHEAPLDMRMDREQTLTAYDVVNTWPYEQLVKIFFQYGEEKFSKAIARKIEQTRKQKPIETTTELAEVIKEAIPAPARRTGGHPAKRVFQAIRIAVNDELRAFEEAIEQAIDLLKPGGRISVITFHSLEDRICKIAFKQASETPHLPPGLPIIPDEYKPKLKIITKKPIVPSEEELQHNHRARSAKLRIAEKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_SHEFN
Sequence: MSATGEEMTQQSYIQHHLTNLTVGEGFWTWNIDSLLFSVGLGMLFLWLFYRAGKKATTGVPGKFQCFVEIIVEFVDSSVKETFHGRNPVIAPLALTIFVWIFMMNFMDMIPVDWLPSLALLAGVPYLKVVPTTDVNITFSLALGVFVLIIYYSIKVKGVSGFVKELTFQPFNHWAMIPVNLLLETVTLVAKPISLALRLFGNLYAGELIFILIALMYGSNVALSALGVGLQLGWLIFHILVITLQAFIFMMLTIVYLSMAHEDH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CGT_HUMAN
Sequence: MKSYTPYFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK
What is the function of this protein?
Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed:9125199).  Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides (By similarity).
What are the official names of this protein?
2-hydroxyacylsphingosine 1-beta-galactosyltransferase, Ceramide UDP-galactosyltransferase, Cerebroside synthase, UDP-galactose-ceramide galactosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Endoplasmic reticulum.
Protein: SSTT_SALHS
Sequence: MATQRASGLLQRLAQGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPVLVLMLVMASIANHQHGQKTNIRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAQDIVPPSGIVEVLRGLLMSMVSNPIDALLNANYIGILVWAVGLGFALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPVGIFGLVSSTLATTGFSTLWGYAHLLVVLIGCMLLVALMVNPLLVFWKIRRNPYPLVFACLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGVPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGIPNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQAEDERLANNALRS
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OSGEP_DROME
Sequence: MVCALGIEGSANKIGIGIIRDGKVLANVRRTYITPPGEGFLPKETAKHHREAILGLVESSLKEAQLKSSDLDVICYTKGPGMAPPLLVGAIVARTLSLLWNIPLLGVNHCIGHIEMGRLITGAQNPTVLYVSGGNTQVIAYSNKRYRIFGETIDIAVGNCLDRFARIIKLSNDPSPGYNIEQLAKSSNRYIKLPYVVKGMDVSFSGILSYIEDLAEPGKRQNKRKKPQEEEVNNYSQADLCYSLQETIFAMLVEITERAMAHCGSNEVLIVGGVGCNERLQEMMRIMCEERGGKLFATDERYCIDNGLMIAHAGAEMFRSGTRMPFEESYVTQRFRTDEVLVSWRDD
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
What are the official names of this protein?
Probable tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein Tcs3, tRNA threonylcarbamoyladenosine biosynthesis protein Tcs3.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TM116_HUMAN
Sequence: MKHTQSGQSTSPLVIDYTCRVCQMAFVFSSLIPLLLMTPVFCLGNTSECFQNFSQSHKCILMHSPPSAMAELPPSANTSVCSTLYFYGIAIFLGSFVLSLLTIMVLLIRAQTLYKKFVKSTGFLGSEQWAVIHIVDQRVRFYPVAFFCCWGPAVILMIIKLTKPQDTKLHMALYVLQALTATSQGLLNCGVYGWTQHKFHQLKQEARRDADTQTPLLCSQKRFYSRGLNSLESTLTFPASTSTIF
What are the official names of this protein?
Transmembrane protein 116.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.