PharMolix/UniProtQA huggingface dataset:
Protein: UQCC6_MOUSE
Sequence: MPGGVPWSAYLKMLSSSLLAMCAGAQVVHWYYRPDLTIPEIPPKPGELKTELLGLKERRHEPHVSQQ
What is the function of this protein?
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263, PubMed:35977508).  Mediates early complex III biogenesis (PubMed:35977508).  Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (PubMed:35977508).  Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity).
What are the official names of this protein?
Ubiquinol-cytochrome-c reductase complex assembly factor 6, Protein BRAWNIN.
What is the protein family that this protein belongs to?
Belongs to the UQCC6 family.
Protein: DNAA_BURM7
Sequence: MNDFWQHCSALLERELTPQQYVTWIKPLAPVAFDAAANTLSIAAPNRFKLDWVKSQFSGRISDLARDFWNAPIEVQFVLDPKAGQRSPAGATPLAPRAPLPSANPAPVGPGPACAPAVDAHAPAPAGMNAATAAAVAAAQAAQAAQANAAALNADEAADLDLPSLTAHEAAAGRRTWRPGAANANSEAADSMYERSKLNPVLTFDNFVTGKANQLARAAAIQVADNPGISYNPLFLYGGVGLGKTHLIHAIGNQLLLDKPGARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKSRTQEEFFYAFEALVANKAQVIITSDTYPKEISGIDDRLISRFDSGLTVAIEPPELEMRVAILMRKAQSEGVSLSEDVAFFVAKHLRSNVRELEGALRKILAYSKFHGREITIELTKEALKDLLTVQNRQISVENIQKTVADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIADERGKDAQLNHELHVLEQTLKG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYPH_BRANA
Sequence: MVNPKVYFDMTVGDKAAGRIVMELYADTVPETAENFRALCTGERGIGKSGKPLHYKGSAFHRVIPKFMCQGGDFTAGNGTGGESIYGMKFKDENFVKKHTGPGILSMRNAGSNTNGSQFFICTEKTSWLDGKHVVFGQVVEGMDVVRDIEKVGSDSGRTSKKVVTCDCGQL
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase, PPIase, Cyclophilin, Cyclosporin A-binding protein, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_CAMC5
Sequence: MSDKKRVLVKFSGEALAGDSGFGIDTAILKFIADEIKELVTNGTEVCIVIGGGNIIRGVSAAKDGIIRRTSGDHMGMLATVINSIAMREALERGGLDVRVQSAIKMEAICETFIVGRANRHLEKGRVVIFAAGTGNPFFTTDTAATLRAIEIGSDMIIKATKVDGVYDKDPNKFKDAKLLKSLSYEKAMSDDIKVMDDTAIALAKDNSLPILVCNMFKQGNLLKIISEDAKALYSIVK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMEB1_BOVIN
Sequence: MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENNTAVVAVETHTIHKIEEGIDASTIEANEDMEIAYPITCGESKAILLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGSITQIAISEESMEEAGLEWNSALTAAVTMATEEGVKKDSEEISQDTLMFWKGIADVGLMEEVVCNIQKEIEELLRGVQQRLIQAPFQVTDAAVLNNVAHTFGLMDTVKKVLDNRKNQVEQGEEQFLYTLTDLERQLEEQKKQAQDHRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPPVHQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSSSPDTVTIHPSSSLALLSSTAMQDGSTLGNMTTMVSPVELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDPEAEDTEGKAVILETELRTEEKVVAEMEEHQHQVHNVEIVVLED
What is the function of this protein?
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids.  Binds also to the transferrin receptor promoter (By similarity).
What are the official names of this protein?
Glucocorticoid modulatory element-binding protein 1, GMEB-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Protein: AROB_BURVG
Sequence: MITVNVDLGDRAYPIHIGAGLIGRTELFAPHINGSSVTIVTNTTVDPLYGDALRAALAPLGKRVSTVVLPDGEAYKNWETLNLIFDGLLTERADRKTTLIALGGGVIGDMTGFAAACYMRGVPFIQVPTTLLSQVDSSVGGKTGINHPLGKNMIGAFYQPQAVVADIGALATLPDRELAAGIAEVIKTGAIADAEFFDWIEANVDALNRREPAVLVHAVKRSCEIKASVVAADEREGGLRAILNFGHTFGHAIEAGLGYGEWLHGEAVGCGMVMAGDLSVRLGLLDEASRQRLDAVIAAARLPVSGPALGEARYMDLMRVDKKAEAGAIKFILLKRFGDTLIAPAPDEAVFATLAKTTR
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNS1D_RATEX
Sequence: MGLEKSLILFSLLVLVLGWVQPSLGRKPSVQDFKRQHMDPDSPPNSRPTYCNQMMKRRGMTKGSCKRVNTFVHESWATVKAICSQRQMTCKTSSRNNCHKSSSPLHITDCRLKGSSKYPNCDYTTTNSQKHIIIACEGNPLVPVHYDASV
What is the function of this protein?
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides.  Acts on single-stranded and double-stranded RNA (By similarity).
What are the official names of this protein?
Ribonuclease pancreatic delta-type, RNase 1 delta.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: GYRA_MYCFV
Sequence: RGIFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYCVTGDALVRLPFGQSVRLRDVVAGARSSSDNAIDLKVLNRHGDPVVADKLFHSGEHETYTVRTAEGYEVTGTANHPLLCLVDVGGVPTLLWKLTEEIRPGDHVVLQRTPPTEFGPADWQDAFEALHLGAFISEGFVSENRAGFNNLDREFFNAVLTAYDTIVGGPRYVSSRTIASDSLLHELDVHNLTALKKSRLGELVGQRSADKAVPEWLWKAPAVVKRVFLQALFEGDGSCSALPRNTIQVSYSTRSGRLAKDIQQMLLEFGVISRRYVHATGEHKVVLTSRAQAELFAAQIGFGGIKQAKLQGLLDALPQAAAGRDGDYVPGLAQFVRKHSGSRWVDKDWLNRHNIDRLSRWQRDGAEILGRIADPDVRAIAQELTDGRFYYARVASVTDSGVQPVYSLRVDTDDHSFITNGFVSHNTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHN
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIC1_AGRFC
Sequence: MGLPFQIEYGQTTGRPELIEDALRQFSAALALTADAGGLYVHGYDESRNQRWANPASGKSPAIWARAVGWLAMALVDALVILPDDSATAELRERTRRLLAGIIARQTQAGLWMQVLDNQGLAGNYAETSASAMFAYALLRAARLGLLRGEEAKAALSAGRQALAALLETRLELDEQGVARLTGIVHVAGLGGFDGNYRDGTPDYYLTEPVVSDDAKGVGPLMMAYAESLLLAR
What is the function of this protein?
Seems to regulate the surface properties of the bacterium in the presence of plant cells or plant cell extracts.  Mutations in this protein are responsible for an increased aggregation of the bacteria in the presence of pea root cap cells (By similarity).
What are the official names of this protein?
Protein Atu3128.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 88 family.
Protein: RL34_ECO8A
Sequence: MKRTFQPSVLKRNRSHGFRARMATKNGRQVLARRRAKGRARLTVSK
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PTN4_MOUSE
Sequence: MTARFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFRVNKHDQGQVLLDIVFKHLDLTERDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYNLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLSCPCNTAALLASFAVQSELGDYNQSENLAGYLSDYSFIPNQPQDFEKEIAKLHQQHVGLSPAEAEFNYLNAARTLELYGVEFHYARDQSNNEILIGVMSGGILIYKNRVRMNTFLWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKTLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSLSDDRLETQSLPSRSPPGTPNHRNSSFTQEATRVRPSSVGHLVDHVVHMSPSEDFVSQRSPSSTQANSIVLESSPSQETPEDGQPPALPPKQSKKNSWNQIHFSNSQQDLVTHTNESFDVPSSPEKSTPNGGIPHDNLVLIKMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCEKHSGELVLLVRPNAVYDVVEEKLESEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLAQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVLLKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCKDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPSESSSYGCYQVTCHSEEGNPAYIFRKMTLFNQEKNESRQLTQIQYTAWPDHGVPDDSSDFLDFVCHVRDQRAGKEEPIIVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSSNK
What is the function of this protein?
Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:17953619, PubMed:25825441).  Regulates neuronal cell homeostasis by protecting neurons against apoptosis (By similarity).  Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441).  Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (PubMed:18614237).  May act at junctions between the membrane and the cytoskeleton.
What are the official names of this protein?
Tyrosine-protein phosphatase non-receptor type 4, Testis-enriched protein tyrosine phosphatase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein: DNAK_STRP7
Sequence: MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEDYLGEKVTKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDKEEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNKLGGDDFDQKIIDHLVAEFKKENGIDLSTDKMAMQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMTLTRAKFDDLTRDLVERTKVPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQTIVIQSNSGLTDEEIDRMMKDAEANAEADKKRKEEVDLRNEVDQAIFATEKTIKETEGKGFDAERDAAQAALDDLKKAQEDNNLDDMKAKLEALNEKAQGLAVKLYEQAAAAQQAQEGAEGAQATGNAGDDVVDGEFTEK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ZBT22_HUMAN
Sequence: MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTITTAAATSVTVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIMPQKHWVYVKRGGNCPAPTPLVPQDPDLEEEEEEEDLVLTCEDDEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPVAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAEHGAVTVGGTSVGSLGVPGSVGGVPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERRHRLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVEMGFGGGGGAN
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 22, Protein BING1, Zinc finger and BTB domain-containing protein 22A, Zinc finger protein 297.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RHG01_MOUSE
Sequence: MDPLSELQDDLTLDDTSQALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPEPVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGRKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKSPGQDPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVEVTQQVLQTLPEENYQVLHFLTAFLVQISAHCDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSTDAQGV
What is the function of this protein?
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state.  Cdc42 seems to be the preferred substrate (By similarity).
What are the official names of this protein?
Rho GTPase-activating protein 1, Rho-type GTPase-activating protein 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREF_PARP8
Sequence: MRIAELTALLHLASPALPIGAFSYSQGLEAAIEAQFITDADTACAWIRSGLSNVLAHGELPFLAHQIERWRTHDAAALIEGNREFLASRESAELRRETEQMGWSLRQLCASLEWGDAARRATLASMAPIAQPTAFAFAAIAHDAATDAALAAYAFSWVENQAAAALKAVPLGQLAGQRIIVALREPIDAAVRQALSTSPDDINTFAPQLGILSARHESQYSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBP_PEA
Sequence: MASTQCFLHHQYAITTPTRTLSQRQVVTTKPNHIVCKAQKQDDVVDAVVSRRLALSVLIGAAAVGSKVSPADAAYGEAANVFGKAKTNTDYLPYNGDGFKLLVPAKWNPSKEREFPGQVLRYEDNFDATSNVSVLVQTTDKKSITDYGSPEEFLSKVDYLLGKQAFFGQTDSEGGFDTNAVAVANILESSAPVIGGKQYYNISVLTRTADGDEGGKHQLITATVKDGKLYICKAQAGDKRWFKGARKFVEDTASSFSVA
What is the function of this protein?
May be involved in the regulation of photosystem II.
What are the official names of this protein?
Oxygen-evolving enhancer protein 2, chloroplastic, OEE2, 23 kDa subunit of oxygen evolving system of photosystem II, 23 kDa thylakoid membrane protein, OEC 23 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the psbP family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: RS5_FLAPJ
Sequence: MYHKYKNVELVKPSGLELKDRLVSVNRVTKVTKGGRAFGFSAIVVVGDENGVVGHGLGKSKDVSEAIAKAVEDAKKNLVKIPLSGKSVPHEQKGKFGGARVNLMPASHGTGVIAGGAVRSVLESVGIHDVLSKSQGSSNPHNVVKATFDALLQMRSAYTVSRQRGISLEKVFKG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: PYRB_PARD8
Sequence: MKSKSLVSIDQCSKEDILRILDNARKFEENPNRKLLEGKVAATLFFEPSTRTRLSFETAVNRLGGRVIGFSDASTTSSSKGETLKDTILMVSNYVDLIIMRHHLEGAARYASEVTDVPIINAGDGANQHPSQTMLDLYSIRKTQGKLDNLTITMVGDLKYGRTVHSLIVGMSHFHPTFHFVAPNELRMPDEQKNFCDKHGLKYEEHTDFTEDIINQTDILYMTRVQRERFTDLEEYERVKNVYILRNDMLRNSRENLRILHPLPRVNEIAYDVDDNPKAYYIQQARNGLFARQAIICEVLGISIDE
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RS9_BACP2
Sequence: MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREITEYIPFAALIEDVKQPLNITETANSYDVLVTVHGGGFSGQAGAIRHGISRALLEVDPEYRTSLKRAGLLTRDPRMKERKKYGLKGARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RH58_ORYSJ
Sequence: MAAFSGCASPLSTTLRSGLAPFTLRHRLRLRRLRASAATLREVCAGRVPEHVLQRAEEVGYVVPTEVQEQSLPVLLSGQDCILHAQTGSGKTLAYLLSVFSAIDFGRSSVQALVVVPTRELGMQVTKVARILAAKACTVMALLDGGMLRRQKSWVKAEPPAIIVATVASLCQMIEKRAFSLQSMRVLVIDEVDFIFGSSKQVSSLRKILTSYSAASSRQTIFASASIPQHNRFVHDCVQHKWTKTDVVHVHVNPVQPMPSHLQHKYAICSKKERLHVLLSLLEKDAPKSGIIFVAEQSEKSKKAGHPPSTTVVVEFLRTTYMGSLEVLLLEEDMNFNARATSFTEVKGKGFLLVSTDIASRGFDLPQTSHIYNFDLPKTAIDYLHRAGRTGREPFSKLACSVTTLITEDEHFVLQRFQNELKFHCEELPVESMFAFNL
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 58, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL7_FRATM
Sequence: MAITKEDILNAVAEMSVMDVCDLVKMMEDKFGVSAAAATVAVAAGPVAGPAEAAEEKTEFDVVLVDAGSNKIAAIKAVRGATGLGLKEAKDAVEGTPFTVKEAASKEEAEALKKQLEEAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: ISPE_PSEPW
Sequence: MHRLTLPAPAKLNLWLHIIGRRPDGYHELETVFQFLDHGDELTFALREDGAIRLHTEIEAVPHDSNLIVRAARRLQEQSGTGLGADIWLTKVLPMGGGIGGGSSDAATTLLALAHLWQLDWDEDRLAALGLTLGADVPVFVRGHAAFAQGVGEQLTPVDPAEPWYVVLVPQVSVSTVEIFSHPQLTRDSLPLKMRPVPEGNSRNDCQPVVEQSYPEVRNALNSLGKFTEARLTGTGSCVFGAFPSKAEADKVLALLSATQTGFVAKGSNVSMLHRKLQSLVKKSSA
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: TANK_HUMAN
Sequence: MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRKETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTATETQCSVPIQCTDKTDKQEALFKPQAKDDINRGAPSITSVTPRGLCRDEEDTSFESLSKFNVKFPPMDNDSTFLHSTPERPGILSPATSEAVCQEKFNMEFRDNPGNFVKTEETLFEIQGIDPIASAIQNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDHNALYVNSFPLLDPSDAPFPSLDSPGKAIRGPQQPIWKPFPNQDSDSVVLSGTDSELHIPRVCEFCQAVFPPSITSRGDFLRHLNSHFNGET
What is the function of this protein?
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.  Acts as a regulator of TRAF function by maintaining them in a latent state.  Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation.  Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989).  Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).  Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989).  May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
What are the official names of this protein?
TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAF.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APCD1_MOUSE
Sequence: MSRVRRLLLGYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFMTRSYRFYNNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHGVQVICHTEAVAEQLSRLVNRTCPGFLAPGGPWVQDVAYDLWQEESNHECTKAVNFAMHELQLIRVEKQYPHHSLDHLVEELFLGDIHTDATQRVFYRPSSYQPPLQNAKNHNHACIACRIIFRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVCKHPTFTIYARGRYSRGVLSSKVMGGTEFVFKVNHMKVTPMDAATASLLNVFSGNECGAEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDTRGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASSSPRAEELLEDSQGHLYGRAAGRTAGSLLLPAFVSLWTLPHWRILR
What is the function of this protein?
Negative regulator of the Wnt signaling pathway.  Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin.  May act via its interaction with Wnt and LRP proteins (By similarity).
What are the official names of this protein?
Protein APCDD1, Adenomatosis polyposis coli down-regulated 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the APCDD1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PLSX_CHRSD
Sequence: MTVRIAIDAMGGDLGPRATVLGSLQALSMHPDLEIQMYGPREALEDELETLPKRLSGYRSRLVLHDAPRVISQAMRVASALREAEGSSMLGALSGVREGRAQACVSAGNTGALMALGRRELGTISGISRPAISTAVPTQDGGRCYLLDLGANVDVQTRHLVDFARMGAVMARVVDEVAVPRVALLNIGVEANKGVPSVRDADRCLREDASRRIGDGTFDYIGYLEGDGIFSGAADVVVCDGFVGNAVLKASEGLATMLLTRLQETFEAHLTTRMVRAMARPALLRLKRRLDPVRYNGASLLGLAGIAVKSHGGADAKGFAYAVSRAVREIDMDLPAHLARALSDEGAAKPSTHSAAAVGGRVDSGLASDARPDDSHPQR
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: TGT_METFK
Sequence: MEFTLIKQDGAARRGTVSLAHGDVQTPAFMPVGTYGAVKSLSPVEVRDTGAHILLGNTFHLWLRPGLEVIGEFGGLHRFMGWNGPILTDSGGFQVWSLGDLRKITEEGVRFRSPINGDSCFLTPEESMRIQKVLNSDIVMIFDECTPYPATPADARDSMLLSLRWAARSKAAHQGNPNALFGIIQGGMYEDLRDESLAGLTEIGFDGYAIGGLSVGEPKEDMLRILAHTTPKMPQDKPRYLMGVGTPEDLVAAVSHGVDMFDCVMPTRNARNGWLFTRHGDIKLKNARHRKDTRPLDEHCQCYTCLNFSRAYLHHLHRSGEILGARLNTIHNLHYYQELMLGMRQAIEQGRFEAFATEFRQGRQMLQQSA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.