PharMolix/UniProtQA huggingface dataset:
Protein: IBPB_PECCP
Sequence: MRNYDLSPLLRQWIGFDKLASSMQGSQEPIDFPPYNIEKKDDNHYRITLALAGFRQSDLDIEVEGPRLTVKGSPAPTEKAVEYLHQGLVFKPFTLSFTLAEHLHVSDAHFENGLLHIDLVRDVPEALQPQRIAIGGGRPALNQQPAEDA
What is the function of this protein?
Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpB, 16 kDa heat shock protein B.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URK_SALHS
Sequence: MTDQSHQCVIIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLQALKRGSAIELPVYSYVEHTRMQETVRVEPKKVIILEGILLLTDARLREEMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_BORPE
Sequence: MAQTLYDKLWDAHVVHQESDGTCMLYIDRHLLHEVTSPQAFEGLALAGRQPWRVGANLAVADHNVPTLNRAQGIEDPISRLQVDTLDDNCAKYGITEFRMNDLRQGIVHVIGPEQGATLPGMTVVCGDSHTSTHGALGALAFGIGTSEVEHVLATQTLLMKKAKSMQINVEGELPFGCTAKDVVLHIIGIIGTAGGTGHAIEFSGSTIRGLSVEGRMTVCNMAIEAGARSGMVAVDDKTIDYFRGRPFAPVGVLWDQAVGYWRTLHSDAGARFDRVINVDARDIKPQVTWGTSPEMVLPVDGRVPDPDREKDDVRRSGMERALEYMGLKPNTPLVDIRVDRVFIGSCTNSRIEDLRAAAVVARGKRVAANVRQAMVVPGSGLVKQQAEREGLDKIFIEAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAVAGHFVDVRSFR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: YRHA_ECOLI
Sequence: MMTKTQINKLIKMMNDLDYPFEAPLKESFIESIIQIEFNSNSTNCLEKLCNEVSILFKNQPDYLTFLRAMDGFEVNGLRLFSLSIPEPSVKNLFAVNEFYRNNDDFINPDLQERLVIGDYSISIFTYDIKGDAANLLI
What are the official names of this protein?
Putative uncharacterized protein YrhA.
Protein: RR7_POPAL
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQILYRAMKKIQQKTETNPLSVLHQAIRGVTPDIAVKARRVGGSTHQVPIEIGSTQGKALAIRWLLGASRKRPGRNMVFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RGPD2_HUMAN
Sequence: MRRSKAYGERYLASVQGSAPSPGKKLRGFYFAKLYYEAKEYDLAKKYVCTYLSVQERDPRAHRFLGLLYELEENTEKAVECYRRSLELNPPQKDLVLKIAELLCKNDVTDGRAKYWVERAAKLFPGSPAIYKLKEHLLDCEGEDGWNKLFDWIQSELYVRPDDVHMNIRLVELYRSNKRLKDAVARCHEAERNIALRSSLEWNSCVVQTLKEYLESLQCLESDKSDWRATNTDLLLAYANLMLLTLSTRDVQESRELLESFDSALQSAKSSLGGNDELSATFLEMKGHFYMHAGSLLLKMGQHGNNVQWQALSELAALCYVIAFQVPRPKIKLIKGEAGQNLLEMMACDRLSQSGHMLLNLSRGKQDFLKEVVETFANKSGQSVLYNALFSSQSSKDTSFLGSDDIGNIDVQEPELEDLARYDVGAIQAHNGSLQHLTWLGLQWNSLPALPGIRKWLKQLFHHLPQETSRLETNAPESICILDLEVFLLGVVYTSHLQLKEKCNSHHSSYQPLCLPLPVCKRLCTERQKSWWDAVCTLIHRKAVPGNSAELRLVVQHEINTLRAQEKHGLQPALLVHWAKCLQKMGRGLNSSYDQQEYIGRSVHYWKKVLPLLKIIKKNSIPEPIDPLFKHFHSVDIQASEIVEYEEDAHITFAILDAVHGNIEDAVTAFESIKSVVSYWNLALIFHRKAEDIENDAVFPEEQEECKNYLRKTRDYLIKIIDDSDSNLSVVKKLPVPLESVKEMLKSVMQELEDYSEGGPLYKNGSLRNADSEIKHSTPSPTKYSLSPSKSYKYSPKTPPRWAEDQNSLRKMICQEVKAITKLNSSKSASRHRWPTENYGPDSVPDGYQGSQTFHGAPLTVATTGPSVYYSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIAVSADGFKFGISEPGNQEKKSEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFGKKDPNFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDACKTEDSDDIHFEPVVQMPEKVELVTGEEGEKVLYSQGVKLFRFDAEISQWKERGLGNLKILKNEVNGKPRMLMRRDQVLKVCANHWITTTMNLKPLSGSDRAWMWLASDFSDGDAKLERLAAQFKTPELAEEFKQKFEECQRLLLDIPLQTPHKLVDTGRAAKLIQRAEEMKSGLKDFKTFLTNDQTKVTEEENKGSGTGAAGASDTTIKPNPENTGPTLEWDNYDLREDALDDNVSSSSVHDSPLASSPVRKNIFRFDESTTGFNFSFKSALSLSKSPAKLNQSGTSVGTDEESDVTQEEERDGQYFEPVVPLPDLVEVSSGEENEQVVFSHMAELYRYDKDVGQWKERGIGDIKILQNYDNKQVRIVMRRDQVLKLCANHRITPDMSLQNMKGTERVWVWTACDFADGERKVEHLAVRFKLQDVADSFKKIFDEAKTAQEKDSLITPHVSRSSTPRESPCGKIAVAVLEETTRERTDVIQGDDVADAASEVEVSSTSETTTKAVVSPPKFVFGSESVKRIFSSEKSNPFAFGNSSATGSLFGFSFNAPLKSNDSETSSVAQSGSESKVEPKKCELSKNSDIEQSSDSKVKNLSASFPMEESSINYTFKTPEKEPPLWHAEFTKEELVQKLSSTTKSADQLNGLLRETEATSAVLMEQIKLLKSEIRRLERNQEESAANVEHLKNVLLQFIFLKPGSERESLLPVINTMLQLSPEEKGKLAAVAQGLQETSIPKKK
What are the official names of this protein?
RANBP2-like and GRIP domain-containing protein 2, Ran-binding protein 2-like 2, RanBP2-like 2, RanBP2L2.
Protein: TVB14_HUMAN
Sequence: MVSRLLSLVSLCLLGAKHIEAGVTQFPSHSVIEKGQTVTLRCDPISGHDNLYWYRRVMGKEIKFLLHFVKESKQDESGMPNNRFLAERTGGTYSTLKVQPAELEDSGVYFCASSQ
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 14.
What are the subcellular locations of this protein?
Cell membrane.
Protein: CLPX_STAS1
Sequence: MFKFNEDEENLKCSFCGKDQDQVKKLVAGSGVYICNECIELCSEIVEEELAQSEPEGLTELPTPKEIMDKLNDYVIGQEKAKKSLAVAVYNHYKRVQQLGPNEDEVELQKSNVALIGPTGSGKTLLAQTLAKTLNVPFAIADATSLTEAGYVGDDVENILLRLIQAADFDIDKAEKGIIYVDEIDKIARKSENTSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPNQELIQIDTTNILFVLGGAFDGIDEVIKRRLGEKVIGFSSSEASKYDEDAILEQIRPEDLQSYGLIPEFIGRVPIVANLETLDVDALKNILTQPKNALVKQYTKMLELDDVTLEFTDEALSAISNKAIKRKTGARGLRSIIEEALIDIMYDVPSSDGVVKVVITAETINDEKEPELYDKDGNLVNKEQTSA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: LSM6_CANGA
Sequence: MAEESVSTQFLSNIIGKPVHVKLYSGMLYSGVLESIDGFMNVALSETREHYEHPNNNLLKKYASDVFLRGTQVMYISEA
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL31_CLOBB
Sequence: MKQGIHPEYHTDAVVKCACGNSFTTGSVKEELKVEICSKCHPFFTGKQKIVDVGGRVEKFNKRFNLDTK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: GPPA_ESCF3
Sequence: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPIDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLKANHELLTLTLPQGWLTQHPLGKEIIDQESQWQSYVHWPLEVH
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: STHA_STUS1
Sequence: MAVYNYDVVVLGSGPAGEGAAMNAVKAGRKVAVVDNRPLVGGNCTHLGTIPSKALRHSVRQIMQYNTNPLFRQIGEPRWFSFPDVLKSAEKVISKQVTSRTSYYARNRIDTFFGTASFSDEQSVEVVCLNGMVEKLVANQFVIATGSRPYRPADIDFNHPRIYDSDTILTLSHTPRRMIIYGAGVIGCEYASIFSGLGVLVDLIDNREQLLSFLDDEISDALSYHLRNNNVLIRHNEEYERVEGLENGVILHLKSGKKIKADAFLWSNGRTGNTDKLGLENIGLKANSRGQVQVDEHYRTEIGNIYAAGDVIGWPSLASAAYDQGRSAAGSIVENDSWRFVDDVPTGIYTIPEISSIGKNERELTQAKIPYEVGKAFFKSMARAQISFEPVGMLKILFHRETLEVLGVHCFGYQASEIVHIGQAIMNQKGPANSIKYFVNTTFNYPTMAEAYRVAAFDGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Protein: ISPE_PROM3
Sequence: MSISSPSAASGHLVSVSAPAKINLHLEVLGLRSDGFHELAMVMQSIELADQLHFRNTADGTISLRCDDSSLSTAGDNLIVQAAHLLRERSGFSELGAAIELQKRIPIGAGLAGGSSDGAATLVGLNGLWNLNFSQGQLEGFAAELGSDMPFCLAGGSQLCFGRGERLESLQAMQASMAVVLVKDPSVSVSTPWAYGRCKELFRSRYLSQESDFEQRRQQLRESSWLNPLRADDPPPLHNDLQAVVAPEVFAVQTTLKLLSDLPGSLAVAMSGSGPSCFALFADVDSAQAALKRQQPAFDAAGLSSWCCAFRSEGIKLEA
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: DCUP_JANSC
Sequence: MADKKKLLRSLAGEAMDVPPVWLMRQAGRYLPEYRATRAQAGDFLSLCYNPELAAEVTLQPIRRFDFDASILFADILLIPQALGANLWFVTGEGPRLSTITDASGMARMKTADDIHETLNPIYETVKILAQELPKETTLIGFAGAPWTVATYMIAGRGTPDQAPAHKLREGDPETFDKLMDLITAATIEYLDMQVQAGAEVVKLFDSWAGSLKGEAFDKYALAPAKRIISELKSRHPDLPIIAFPREAGEKYIGFANAVGADCLAIDTSVDAIWAAENLQTDGCVQGNLDPKLMVTGGEALASEARRIRDALKGGPHIFNLGHGITPDADPENVHILLDAIRS
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOD3A_XENLA
Sequence: MAFLNLFFCLVFISPLMAMPPVLQGRKSISPDSILKDTSTDIGAREFQGRKFPNFMMQLYQNIIRGRDNDLSNLEHPTLQESDTVQSFIAKSYTTVGNRWTLFFDMSSISRSNELKLAELRICLPSFRKSHSVTVDIYHTNDGKEKLFMGSFKTKLSSALDSDCKVFNLTILLQNFLTRGKRLIKDEYIQAKGLHLKDLEKSATEKDTENVDTMKQHQYHVSDFAAERIMLVVFAKEQSHAKPDPPSLGQKLFPSKYGIDDNANKVNGFRRLRRNKKEKTQIHVSTVPPKPIEEIKPECKKVDMFVDFQKIGWGSWIIYPKAYNAYRCESTCAVPQNETENATNHSYIKSLLPLSDMERKECPSCVPMKMMSMSMLYYENEDFILRHHEEMIVEECGFKDM
What is the function of this protein?
Exhibits mesoderm-dorsalizing activity and neural-inducing activity, but lacks mesoderm-inducing activity.  Regulates the expression of specific mesodermal and neural genes.  Induces convergent extension movements at the embryonic midline by activating the fgf signaling pathway to induce t/bra expression in the organizer region.  Acts with wnt11 to induce Spemann organizer cells and induce axis formation.  The unprocessed protein antagonizes bmp-signaling.
What are the official names of this protein?
Nodal homolog 3-A, Nodal-related protein 3-A, Xnr3, Xnr3-A.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RHTC_ECO57
Sequence: MLMLFLTVAMVHIVALMSPGPDFFFVSQTAVSRSRKEAMMGVLGITCGVMVWAGIALLGLHLIIEKMAWLHTLIMVGGGLYLCWMGYQMLRGALKKEAVSAPAPQVELAKSGRSFLKGLLTNLANPKAIIYFGSVFSLFVGDNVGTTARWGIFALIIVETLAWFTVVASLFALPQMRRGYQRLAKWIDGFAGALFAGFGIHLIISR
What is the function of this protein?
Conducts the efflux of threonine.
What are the official names of this protein?
Threonine efflux protein.
What is the protein family that this protein belongs to?
Belongs to the Rht family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DPO1_RICCN
Sequence: MTQKNTLLLIDGYGFVFRAYYAQQPLTSPKGEPVGALYGFTSMLLKLLSDFKPKHVAVVFDSGGKNFRHQIYPDYKANRPPPPEDLIIQLPLVRDVASNLNFPILEKNGYEADDIIATFATKTAALGAHVVIISSDKDLLQLMTENIKIYDPLKGKYITEDDVVKKFGTTSDKLREVMALIGDRSDNIPGVPSIGPKTASSLITQFGSVENIFNSLDQVSSVKQRETLQNSREAALISWQLIGLNSNVDLDFQLNNLEWSPPNSDKLTGFLQEYGFRSLYKRVENLLDIKINDHKEIADSKVTEIKELNNANELADFAKEATKIGIFGIYLLQHKGANLAFILSLQNQSYIIKISNTSHDLFSYNTKSNNNWFSDIIFNLLTDKSIKKITYSLKPLLKFYANQSHDITAIEDLELMQYALSAGLSQKNLFKEVLKETWIENIIIESAKIVINFIALYKQTIWELKDNKTFRLYSNIDLPICFILDKMEKVGITVDANYLKQLSAEFGTEILKLEEEIFALSGTKFNIGSPKQLGEILFEKMQLPFGKASAKASSYSTGAEILEKLSEHGYNIADLLLRWRQLTKLKNTYTDSLPKQIDNITHRVHTTFLQTSTTTGRLSSQEPNLQNVPIRSSEGNQIRKAFIAEEGYKLISADYSQIELRILSHIANIDALKQAFINKDDIHTQTACQIFNLQKHELTSEHRRKAKAINFGIIYGISAFGLAKQLNVTNGEASEYIKKYFAEYKGVQEYMEQTKAFASSNGYVTNCFGRKCFVPLIHDKKLKQFAERAAINAPIQGTNTDIIKIAMINLDQEIEKRKLKTRLVLQIHDELLFEAPIDEVEIITPIIKKIMENSTNMAVPIITEIRAGNNWMEIH
What is the function of this protein?
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
What are the official names of this protein?
DNA polymerase I, POL I.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-A family.
Protein: RH40_ARATH
Sequence: MATTEDTPASAGPRYAPEDPTLPQPWKGLIDGSTGILYYWNPETNVTQYERPSAPPPHSATTPKLAQIPVPSSGQGHQAQHEQAKPVGHVSQQHGFQQQPQQFPSQHVRPQMMQQHPAQQMPQQSGQQFPQQQSQSMVPHPHGHPSVQTYQPTTQQQQQGMQNQHSQMPQQLSHQYAHSQQHYMGFRPHMQTQGLQNSHQTPQGGPHGQQFPSQQEYNSLAPKREGDEFHGGKKTGFSQPHLPNSERSPSQNTHFEANAASQKTNANLAMAQKCNGPQANAAVTQFQQPGANLIHQQLGPRAPNQMDQTMLHQKSHVSPFQSNNTYENNLQSRPGNDSYVNMRMEVPVRGAQPLHPAAMPKDIRISGGPPTNADPAMGQTGHGTYGHAGPAFPNKSLVRPHFVTSPDVPHLSPVEIYRKQHEVTTTGENIPAPYITFESSGLPPEILRELLSAGFPSPTPIQAQTWPIALQSRDIVAIAKTGSGKTLGYLIPAFILLRHCRNDSRNGPTVLILAPTRELATQIQDEALRFGRSSRISCTCLYGGAPKGPQLKELERGADIVVATPGRLNDILEMKMIDFQQVSLLVLDEADRMLDMGFEPQIRKIVNEIPPRRQTLMYTATWPKEVRKIASDLLVNPVQVNIGRVDELAANKAITQYVEVVPQMEKERRLEQILRSQERGSKVIIFCSTKRLCDHLARSVGRHFGAVVIHGDKTQGERDWVLNQFRSGKSCVLIATDVAARGLDIKDIRVVINYDFPTGVEDYVHRIGRTGRAGATGVAFTFFTEQDWKYAPDLIKVLEGANQQVPPQVRDIAMRGGGGGGPGYSQDRRGMVNRFDSGGGGTRWDSGGGFGGRGGGFSGREGGFGGREGGFGGREGGFGGRGGRFGMRDDSFGRGGNRGRGFTGPDAGHMNVGGRGGFGRFGNNNNMESRGFGRGSGRGFGRGVGRFDNRRGRSRSRSPDLVRPRRRSSSYSRSRSRSGSYSRSRSRSRSWSRSRSRSPRHSRDRGGHNRSRSYSRSPSPVYERRDRAPRVSGFDIKPPVESVVNLDMNAAAAIENVVPTSLSERQGNGVVESEVEAALVRPVVDEEP
What is the function of this protein?
ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 40.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMG_JANSC
Sequence: MNESDAKHWLSDRVSRETMDRLELYHTLLTRWQKTINLIAPSTIDSVWVRHIMDSAQLFDLASKPAHRWLDLGSGGGFPGLVVAAMAKDVCPNLTVTLVESDIRKCGFLREAARQMDLSVKILSRRIGDVPAQTADVISARALSSLSNLIGHARPHMTPKTCLLFPKGMSYVAELETLPDDWQVNAEVIESVTDSDAVILRFRGAHLEGEG
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAKG3_MOUSE
Sequence: MEPELEHTLPGTLTWSHSGGPESQEMDFLEQGENSWPSPAVATSSERTCAIRGVKASRWTRQEAVEEAEPPGLGEGAQSRPAAESTRQEATFPKATPLAQAVPLAEAETSPTGWDLLLPDCAASAGGSSTGDLELTIEFPAPEAWDCELEGLGKDRPRPGPSPQAPLLGLSWDDELQKPGAQVYMHFMQEHTCYDAMATSSKLVIFDTTLEIKKAFFAMVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLVQIYEIEEHKIETWREIYLQGCFKPLVSISPNDSLFEAVYALIKNRIHRLPVLDPVSGTVLYILTHKRLLKFLHIFGALLPRPSFLCRTIQDLGIGTFRDLAVVLETAPVLTALDIFVDRRVSALPVVNESGQVVGLYSRFDVIHLAAQQTYNHLDMSVGEALRQRTLCLEGVLSCQPHESLGEVIDRIAREQVHRLVLVDETQHLLGVVSLSDILQALVLSPAGIDALSA
What is the function of this protein?
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.  In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.  AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.  AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.  The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism.  It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.  ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit.  ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
What are the official names of this protein?
5'-AMP-activated protein kinase subunit gamma-3, AMPK gamma3, AMPK subunit gamma-3.
What is the protein family that this protein belongs to?
Belongs to the 5'-AMP-activated protein kinase gamma subunit family.
Protein: YDFI_ECOLI
Sequence: MGNNLLSAKATLPVYDLNNLAPRIVHLGFGAFHRAHQGVYADILATEHFSDWGYYEVNLIGGEQQIADLQQQDNLYTVAEMSADVWTARVVGVVKKALHVQIDGLETVLAAMCEPQIAIVSLTITEKGYFHSPATGQLMLDHPMVAADVQNPHQPKTATGVIVEALARRKAAGLPAFTVMSCDNMPENGHVMRDVVTSYAQAVDVKLAQWIEDNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVRDPAGVACEPFRQWVIEDNFVAGRPEWEKAGAELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMEDEHYRYAAYGLMLQEQAPTLKVQGVDLQDYANRLIARYSNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLAHDSKFDLLALGVAGWMRYVGGVDEQGNPIEISDPLLPVIQKAVQSSAEGKARVQSLLAIKAIFGDDLPDNSLFTARVTETYLSLLAHGAKATVAKYSVK
What are the official names of this protein?
Uncharacterized oxidoreductase YdfI.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family. UxuB subfamily.
Protein: TRUA_AQUAE
Sequence: MPNYLLRLAFVGTNFYGWQVQPNLRTVQGEIQKALSQILCEDVKVTGCCRTDSGVHALDYIANFKTQKDFPEEKLLKALNGILPKDVGVYAVKKVSEEFNARYSVKGKVYLYKIWNSEVRNPFLYPFSWQVKREINTEVLRNILKKFEGTHDFRALTKLEEERNTVINLEEVSLNVEYPLIEIRLKASHFLRYMVRRIVGTAVKISLGLYSEEVLEELLQGKGNSPYTAPPQGLHLEKVLL
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: RCLB_ECOLI
Sequence: MFKKSVLFATLLSGVMAFSTNADDKIILKHISVSSVSASPTVLEDTIADIARKYNASSWKVTSMRIDNNSTATAVLYK
What is the function of this protein?
Probably involved in reactive chlorine species (RCS) stress resistance.
What are the official names of this protein?
Uncharacterized protein RclB, Reactive chlorine resistance protein B.
What is the protein family that this protein belongs to?
Belongs to the BhsA/McbA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: HFQ_ECOUT
Sequence: MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNAGGGTSSNYHHGSSAQNTSAQQDSEETE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: RBSD_THEAB
Sequence: MKKTGIFNSEISRVIAKLGHKDKIAIVDLGFPIPSHVERIDIVLDFGRPTFEEVLKVILKELEVEQVILAHESSKKFEQIIKENIPRVEFLKISHEELKKLTNDVVAVIRTGDVVPYSNAILVSGVIF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.