PharMolix/UniProtQA huggingface dataset:
Protein: YPHC_ECOLI
Sequence: MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFINGHEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGEGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGVGTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATTEGLPQIIAELTHGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCAHDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVINFPD
What are the official names of this protein?
Uncharacterized zinc-type alcohol dehydrogenase-like protein YphC.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: SPLF_STAA9
Sequence: MNKNIIIKSIAALTILTSITGVGTTVVDGIQQTAKAENSVKLITNTNVAPYSGVTWMGAGTGFVVGNHTIITNKHVTYHMKVGDEIKAHPNGFYNNGGGLYKVTKIVDYPGKEDIAVVQVEEKSTQPKGRKFKDFTSKFNIASEAKENEPISVIGYPNPNGNKLQMYESTGKVLSVNGNIVSSDAIIQPGSSGSPILNSKHEAIGVIYAGNKPSGESTRGFAVYFSPEIKKFIADNLDK
What are the official names of this protein?
Serine protease SplF.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1B family.
What are the subcellular locations of this protein?
Secreted.
Protein: PURT_SALSV
Sequence: MTLLGTALRPAATRVMLLGAGELGKEVAIECQRLGIEVIAVDRYPDAPAMHVAHRSHVINMLDSEALRHVITEEKPHYIVPEIEAIATDTLRELEGEGLNVVPCARATQLTMNREGIRRLAAEELGLPTSTYRFADSEASFHDAVAAVGFPCIVKPVMSSSGKGQSFIRSAEQLAQAWEYAQQGGRAGAGRVIVEGVVKFDFEITLLTVSAVDGVHFCAPVGHRQQDGDYRESWQPQQMSELALKRAQEIARHVVLALGGHGLFGVELFVCGDEVIFSEVSPRPHDTGMVTLISQDLSEFALHVRAFLGMPVGAIRQYGPAASAVILPQLTSQNVTFDNVHAAVGAGVQVRLFGKPEIDGTRRLGVALATGENVEEAVIRAKKAASRVTVKG
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: CLC6A_BOVIN
Sequence: MVREGNAESCFRMRLWCIAVLGLALLSACFIVSCVVTYYFTHGNTGKRLSELHTHHSNLTCFSEGTRVTEKIWGCCPGTWKPFGSSCYFISSEENFWAKSEQNCIGMGAHLVVINTETEQDFIIQQLNKTFSYFLGLSDPQGNGNWQWIDQTPYKENVRFWHQNEPNFSAEECASVVFWDGRGWGWNDVFCDSKRKSICEMKKIYL
What is the function of this protein?
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C. albicans hypheas (By similarity).  Binding of C. albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity).  Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production.  Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity).
What are the official names of this protein?
C-type lectin domain family 6 member A, Dendritic cell-associated C-type lectin 2, DC-associated C-type lectin 2, Dectin-2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: GVPL2_HALSA
Sequence: MTPAQSQARAQLSDGRYVYCVVDTTSVPSASVGETTGIDDETVRVVSVDGVGAVVHDCTSVYDADDIDQVKRWLVTHQQVVDDVSDVFGTPLPMRFDTVFAGGDSALTDWLADTHPRLRTELDGFAGCWEYRVTLLWDPQPFEAHVTATDDTLQALEARQAEADAGTTFLLEKQYDARLAERRRARRSALASDLSAAVEPVATQVASQDTTTSLRDESVSERHTPIARLAVLAPETDESALGSQLDDIAARDGVTIRFTGPWPPYTFAPDICTDEPNQA
What is the function of this protein?
May play a structural or regulatory role in gas vesicle synthesis.
What are the official names of this protein?
Protein GvpL 2.
What are the subcellular locations of this protein?
Vacuole, gas vesicle.
Protein: COBT_SYNC1
Sequence: MNLLHTTVARIKPQDENIRRQAKDRLDRLTMPHWALGRLLDLALDLAGMTGSLQPPVDRRLIVTMAGDHGVAAEGVSAFPQEVTGQMVANIANGGAGISTLARVANARVQVVDMGAACDLSDLVDSGQILSRRIAPGTANMALGAAMTREQAVRSLEAGIEIANTFAGEADLFGTGEMGIANTTPSSAIVALLADATADQATGCGTGIDDNRRKHKVSVIERALQTNLPDPHDGLDVLAKVGGFEIGGLAGLILGAAALRKPIIIDGFISTAAALLAQSLAPASVDYMIAAHHSIEQGHQLALARLGKKPLLDLDFRLGEGTGAALAMNLVEGAKRLLTEMATFDEAAVSQGK
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: CMC1_YEAST
Sequence: MLLKNCETDKQRDIRYACLFKELDVKGNGQVTLDNLISAFEKNDHPLKGNDEAIKMLFTAMDVNKDSVVDLSDFKKYASNAESQIWNGFQRIDLDHDGKIGINEINRYLSDLDNQSICNNELNHELSNEKVNKFSRFFEWAFPKRKANIALRGQASHKKNTDNDRSKKTTDSDLYVTYDQWRDFLLLVPRKQGSRLHTAYSYFYLFNEDVDLSSEGDVTLINDFIRGFGFFIAGGISGVISRTCTAPFDRLKVFLIARTDLSSILLNSKTDLLAKNPNADINKISSPLAKAVKSLYRQGGIKAFYVGNGLNVIKVFPESSIKFGSFEVTKKIMTKLEGCRDTKDLSKFSTYIAGGLAGMAAQFSVYPIDTLKFRVQCAPLDTKLKGNNLLFQTAKDMFREGGGQIILQRCHSRYSGHISLCCIRFGDFFCLKKMVYCQTGKDPEPTTRSGHSKQPGCTSNGCIQWNCRSFCCLSNQSFKNKTTSPRNICTSLCV
What is the function of this protein?
Calcium-dependent mitochondrial solute carrier.
What are the official names of this protein?
Truncated non-functional calcium-binding mitochondrial carrier SAL1-1, Suppressor of AAC2 lethality.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL10_SYNC1
Sequence: MKKEAKSQVVSEMAQKLASCQAAFLADYRGLTVEQVNQLRGELKKVGVEYRVVKNTLLRLASKGTDAECLSEYLQGPNAIALAEEDPVGPAKVLTQFAKSNKAFELRAAELNGKLLSIDEVKALAELPSKEELLGKMLGSINAPVSNFVGVLAAVPRTFVQVLAAIQQQKEG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: CPCT_SYNP2
Sequence: MSHSTDAHTLARWMAGEFSNEAQALANPPLWAHIKVCMRPLPNQFFDGYGLYLEQAYSSDTSAPYRLRLFHIKPVDDHMELVHYKPKDDAKTKYMGAARNPAMMQHFDMADLDPMPGCDMIVTWSGTSFKGTVQAGKGCRVVRYNKESYLDNSFEITDNALISIDRGRDPVTNEILWGSLAGAFEFEKINNFSGEVQPH
What is the function of this protein?
Attaches a phycocyanobilin (PCB) chromophore to 'Cys-153' of the C-phycocyanin beta subunit (PhcB).  It does not attach chromophore to CpcA, ApcA or ApcB, the other phycobiliproteins.
What are the official names of this protein?
Phycocyanobilin lyase CpcT.
What is the protein family that this protein belongs to?
Belongs to the CpcT/CpeT biliprotein lyase family.
Protein: NU2M_CARAU
Sequence: MNPYVLMILLSSLGLGTTLTFASSHWLLAWMGLEINTLAITPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWMTGEWSITDLSDPLANTMFMTALALKIGLAPMHFWMPEVLQGLDLLTGLILSTWQKLAPFALIIQTAQNIDPLLLTLLGVTSTLVGGWGGLNQTQLRKILAYSSIAHMGWMIIVIQYAPQLTLLALGTYIIMTSAAFLTLKMSLTTKVSTLATTWSKSPILTATTALVLLSLGGLPPLTGFMPKWLILQELTKQDLPIIATTMALAALISLYFYLRLCYAMTLTISPNTTNSTTPWRTQTTQASMPLALFTMATLGLLPMTPAILTLTT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: K1BAA_ANEVI
Sequence: MSRIAILLFVAFLLVAGISAKSTAHFKKNVLADLFKERRFNAKRDPAGSTCVNIDVDSFCDGMAERGACNIIPQMATNCAKACNSC
What is the function of this protein?
Inhibits voltage-gated potassium channels (Kv1/KCNA).
What are the official names of this protein?
U-actitoxin-Avd10a, U-AITX-Avd10a, Potassium channel toxin avtx-10.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 1 potassium channel toxin family. Type 1b subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RECO_STAAN
Sequence: MLMRQKGIIIKAVDYGESDKIITILNEHGAKVPLMARRAKKVKTGLQAQTQLFVYGLFIYNQWRGMGTLNSVDVISQHYKLQMDLYVSSYASLAAETIERSMDEGDIAPYNYQLLQFVLEKIESGTSAQLMSVVVMLKCMKRFGFTASFNRCAVSGNDTQADLIGYSFKFDGAISRQEASKDVHAVILSNKTLYLLDVLQKLPIDKMNSLNIHQEIIDEMSDIILMLYREYAGMFFKSQKLINQLKRLEQ
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: Y1448_MYCBO
Sequence: MATIGEVEVFVDHGADDVFITYPLWIGTRQADRLRQLADRARIAVGAGTAEGASNTGARLADAAGAIDVLIEIDSGHHRSGVRAEQVLEVAHAVGEAGLHLVGVFTFPGHSYAPGKPGEAGEQERRALNDAANALVAVGFPISCRSGGSTPTALLTAADGASETSRRLCAR
What are the official names of this protein?
Uncharacterized protein Mb1448.
Protein: YIDD_SHIBS
Sequence: MAPPLSPGSRVLIALIRVYQRLISPLLGPHCRFTPTCSSYGIEALRRFGVIKGSWLTVKRVLKCHPLHPGGDDPVPPGPFDTREH
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CTX5A_MESEU
Sequence: MCMPCFTTDPNMAKKCRDCCGGNGKCFGPQCLCNR
What is the function of this protein?
Toxin with unknown function in healthy organisms.  On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells.  This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).  Has been shown to weakly inhibit TRPV1 channels (PubMed:29483648).
What are the official names of this protein?
Insectotoxin-I5A, BeIT5A.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPT45_DANRE
Sequence: MSKQERLYELNMHRETWCRVETTSKYWNLPERKHFRCHLQNTCDISALQTASPEQRSAWMSSGGQNTAHPERRHFEDSYRAHLV
What are the official names of this protein?
Spermatogenesis-associated protein 45.
What is the protein family that this protein belongs to?
Belongs to the SPATA45 family.
Protein: RMF1_COLP3
Sequence: MKRQKRDRQSRAHTRGYQAGISGRSKEHCPYQIDAIKSQWLGGWREAIEDKQQGLFK
What is the function of this protein?
During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).
What are the official names of this protein?
Ribosome modulation factor 1, RMF 1.
What is the protein family that this protein belongs to?
Belongs to the ribosome modulation factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP84_BP186
Sequence: MIDSRCFAESTINIVSVSGGKDSLAQWILAVENDVPRTTVFADTGHEHSQTMEYLDYLESRLGPVIRVKADFTRRIEGKRKFIAEKWPVSLVEECGMSHEQAAERIAKALEILKPTGNPFLDLCMWKGRFPSTKARFCSLELKHDSVRDKIVLPALEKYDEVILWQGVRAQESPARAALPMWEEDADNTPGLHVYRPILNWTHEDVFALAKRHGIKPNPLYQQGCSRVGCMPCIHARKSELAEIFARWPEEIARVAEWERLVAACSRRGNSTFFPSTHDPRRAEKRIEVVTVEEYGIASYRDWAMTTRGGSQYDLLAATNDKTVCSSVYAGVCE
What are the official names of this protein?
Uncharacterized 37.8 kDa protein in gpa 5'region.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family.
Protein: FAD3C_HELAN
Sequence: MAGLVLSGCAIKPFSQSLPIPTKRFITNPSNINLLHPKDPIFSPNFHGFSRWAVKVSAPLRIPSIDQQDLDLDLERERISSLDVQEEEIFDAGAPPPFKLADIRAAIPKRCWVKDPWRSMSYVVRDVAIVLGLAAAAAHLNNWLVWPLYWAAQGTMFWALFVLGHDCGHGSFSNNAKLNSVVGHLLHSSILVPYHGWRISHRTHHQNHGHVENDESWHPLTEKTFKSLDWITRTLRFTLPFPMLAYPFYLWNRSPGKSGSHFDPSSDLFVPAEQKDVITSTICWTTMLALLFGLNFVVGPVQMLKLYGIPYLINVMWLDFVTYLHHHGHEDKLPWYRGKEWSYLRGGLTTIDRDYGWINNIHHDIGTHVIHHLFPQIPHYHLIEATEAAKPVLGKYYREPKKSSPIPFHLLGELVRSLKKDHYVSDTGDVLYYQTDDKLSKEK
What is the function of this protein?
Chloroplast omega-3 fatty acid desaturase introduces the third double bond in the biosynthesis of 18:3, and probably also 16:3 fatty acids, important constituents of plant membranes.  It is thought to use ferredoxin as an electron donor and to act on fatty acids esterified to galactolipids, sulfolipids and phosphatidylglycerol.
What are the official names of this protein?
sn-2 acyl-lipid omega-3 desaturase (ferredoxin), chloroplastic, Omega-3 fatty acid desaturase 7, chloroplastic, HaFAD7.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: QUEA_LATSS
Sequence: MVSTEDFDYNLPEELIAQTPMIERAASRLLVMDHETGALEDKVFYDIIDELNPGDAVVMNNTRVLPARLYGVKPDTGGHEEVLLLNNTHDDEWEVLMKPAKRAKVGTEVVFGDGQLRAIVTKELEHGGRMIEFKYDGIFMQILEALGEMPLPPYIKEKLDDPEMYQTVYAKEPGSAAAPTAGFHWTEELLQKVQDKGIKLVYLTLHVGLGTFRPVSEDNVEDHKMHSEFYRLTEEAAATLNEVKQNGGRIVATGTTSIRTLETIATKFDGEIKADSGWTEIFIKPGYQWKAVDAFITNFHLPKSTLVMLVASFTGRENILNAYQHAVDERYRFFSFGDAMFVK
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC_MYCLB
Sequence: MCPATVLDSILKGVRADVAAREACISLSEIKAAAAAAPAPLDAMAALREPGIGVIAEVKRASPSVGSLATIADPAKLAQAYEDGGARIISVLTEERRFNGSLDDLDAVRAAVSVPVLRKDFVVQPYQIHEARAHGADMLLLIVAALDQSALMSMLDRTESLGMIALVEVRTEQEADRALKAGAKVIGVNARDLMTLEVDRDCFSRIAPGLPSNVIRIAESGVRGPADLLAYAGAGADAVLVGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: NU1M_METSE
Sequence: MRKFVFLMIIETIHIILKILIIVIPLLVAVAYLTLAERKVLGYMQARKGPNVVGVYGLLQPLADGIKLFTKELVIPHYANLFIYVAAPVLSFTLALIAWGVIPYDKGVVISDLKIGILFTLAVSSISVYAILMSGWASQSKYAFLGAIRAAAQMISYEVSIGLIIITVILCVGSLNITEIVLAQSSGIWFFFPLFPVAMMFFASALAETNRAPFDLTEGESELVSGYNVEYASMSFALFFLAEYAHIILMSCLTTILFLGGWLSPIVFFKGGPAWFGLKTSFIILLFIWVRASFPRMRYDQLMALLWKSYLPLSLAFVVLVASLLFGLNGLPPS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NSP1_ROTRH
Sequence: MATFKDACFHYRRVTKLNRELLRIGANSVWTPVSSNKIKIKGWCIECCQLTGLTFCHGCSLAHVCQWCIQNKRCFLDNEPHLLKLRTFESPITKEKLQCIINLYELLFPINHGVINKFKKTIKQRKCRNEFDKSWYNQLLLPITLNAAVFKFHSRDVYVFGFYEGSSPCIDLPYRLVNCIDLYDKLLLDQVNFERMSSLPDNLQSIYANKYFKLSRLPSMKLKRIYYSDFSKQNLINKYKTKSRIVLRNLTEFTWDSQTDLHHDLINDKDKILAALSTSSLKQFETHDLNLGRIKADIFELGHHCKPNYISSNHWQPASKISKCKWCNVKYAFRDMDWKMESMYNELLSFIQSCYKSNVNVGHCSSIEKAYPLVKDILWHSITEYIDQTVEKLFNTMNPVQVNEQQVIKFCWQIDIALYMHIKMILETEALPFTFTLNQFNSIIKGIVNQWCDVAELDHLPLCTEQTDALVKLEEEGKLSEEYELLISDSEDDD
What is the function of this protein?
Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7.  Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.
What are the official names of this protein?
Non-structural protein 1, NSP1, NCVP2, Non-structural RNA-binding protein 53, NS53.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP1 family.
What are the subcellular locations of this protein?
Host cytoplasm, host cytoskeleton.
Protein: RS17_LISIN
Sequence: MADRNQRKVYTGRVVSDKMDKTITVVVETYKKHGLYGKRVKYSKKFKAHDENNIAKTGDVVRISETRPLSATKHFRLLEVVEEAVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: GLOM_GLAL2
Sequence: MYKISFAGLLRGNDKDVEALAEAATTQGFLELELDCMEAKALQKDVKFLESFAESILDSPEDVKAAYHFHKTGRFRTTGFKPLGSEEGAKAGNPDGFEFFFLPQKEILLSEFREQLNCPPLAMSNIDTLTDCFKHYERTAQMLLQRLTEGLKLGNELLNAHNTSLPCVTNMGLIRYPPQPKESGNFGHIAHTDVGSLTILAATQRGLQTLDNITQKWIWVDPSDECLFVQLGDSLKFLSRGKILPSLHRVLPSDVAPEATKYTIAYFLRPNEEAEITSDDGKVWLYKDYHCRKFDAFARPLGYRPDGEESLISLRDYTGVE
What is the function of this protein?
2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of pneumocandins, lipohexapeptides of the echinocandin family that prevent fungal cell wall formation by non-competitive inhibition of beta-1,3-glucan synthase (PubMed:27705900).  The 10,12-dimethylmyristoyl side chain is synthesized by the reducing polyketide synthase gloL/GLPKS4 (PubMed:27494047).  The thioesterase gloN/GLHYD exclusively interacts with gloL/GLPKS4 to maintain turnover of the polyketide side chain (PubMed:27494047).  The 10R,12S-dimethylmyristic acid is then transferred to the first thiolation domain of the nonribosomal peptide synthetase gloA/GLNRPS4 by the acyl-AMP ligase gloD/GLligase, followed by its acylation to L-ornithine to trigger elongation of the cyclic hexapeptide (PubMed:27494047).  L-ornithine, 4R-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2), 3S-hydroxyl-L-homotyrosine (generated by gloG/GLHtyB, gloH/GLHtyA, gloI/GLHtyC, gloJ/GLHtyD and hydroxylated at C-3 by the dioxygenase gloM/GLOXY1), 3R-hydroxyl-L-glutamine (generated from L-glutamine probably by the dioxygenase gloE/GLOXY3) and 3S-hydroxyl-L-proline (generated from L-proline by the dioxygenase gloF/GLOXY2 to yield pneumocandin B0), or 3S-hydroxyl-4S-methyl-L-proline (generated from L-leucine by the dioxygenase gloC/GLOXY4 to yield pneumocandin A0) are sequentially added to the growing chain (PubMed:25270390, PubMed:25879325, PubMed:25527531).  The last C domain of gloA/GLNRPS4 is proposed to be responsible for cyclization by condensation to form the peptide bond between L-ornithine and 3S-hydroxyl-4S-methyl-L-proline (for pneumocandin A0) or 3S-hydroxyl-L-proline (for pneumocandin B0).  Finally, the subsequent C-4 hydroxylation of 3S-hydroxyl-L-homotyrosine and L-ornithine dihydroxylation at C-4 and C-5 are performed by the cytochrome P450 monooxygenases gloP/GLP450-1 and gloO/GLP450-2, respectively (PubMed:25879325).
What are the official names of this protein?
2-oxoglutarate-dependent dioxygenase gloM, Homotyrosine 3-hydroxylase, Pneumocandin biosynthesis cluster protein M.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: AROA_CARHZ
Sequence: MKKITAAKKGLKGQVTVPGDKSISHRALILGALAEGITEIENFLVAQDTLATLNCLEKYGVRIERRDTFVRVFGTAQNFSEPQDVLDAQNSGTTLRLLSGVAATFPFVSVFTGDASLRRRPMKRVLEPLTQMGARVLARGQGDYAPFAIKGGKLRGQDFILKKASAQVKSALLLAGLRAEGNTSVTEPQLSRDHTERMLVGFGAKIKREGLRVEISGGQKLLGQKVIVPGDFSTASFFIVAALIVPDSHLIIKNVGLNPTRTGLLTVLKEMGANIQILNFHENSGEPVGDLEVKYSPLKAVEVPPEIVPAMIDEFPILAVAMALAYGESKVRGAEELRVKESDRIKSIVSEFSKMGVAVKELPDGFIISGGNKILGTTVDSHHDHRIAMSLAVLGLTAAGTTEILNADAVAISYPEFFQQLTKLTEGA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXO5_CANGA
Sequence: MTLRDVEKLRLWRLKIFRNQQPILRAKPPHASRKTQYLFQKIDNVKSQFGTDGKGDLLWQRDGMNPYHDLYDPGDLKTHRLSVTKLLTKSWCELRFAYDLYSRLPLFREAHLAAGERTHQKLENSEHTPVIRPQDIPQFSETVEIVEDDLHVLAASWAETITRLIHLFSSGDAREILCHGYLNKETNQLYDPMETEVWDPSQHILISGIIDHLTLTSKNGNLPLNNHHRSIDDSIAKLKNTRNEFAKNGLTIQISDVKTRTRKFIPPQESVQNATKLQLMYYRHFLLSLGTDSDNTYEMLLYNARIRGVDVDQPLNPANCLLIMIQMDGFVGDFVKLQNGDGFQFPKFDNAPISHSFTLADAKHHQFLQNINSHELAGQLLNGTFAKPITLRYFAMRLAQMYSMLTPLISEKLKVEYYHNNECFQEVEFVNDKKSLGESCRSASSFWFGKRAIEPVEATTFNYNQYCKHCDYRDHCAWIKDSLAKSTKLGDELTQIARRIHNI
What is the function of this protein?
Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination.  Releases dinucleotides as main products of catalysis.  Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).
What are the official names of this protein?
Exonuclease V, mitochondrial, Exo V, Defects in morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the EXO5 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TAF6_MOUSE
Sequence: MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGAAAADGKGKEKKAPPLLEGAPFRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRGEFGSLGPLLCSHVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSASSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPAGSGSVQKYIVVSLPPTGEGKGGPPSHPSPVPPSSSSPSPLGGSTLCGGKQEAGDSPPPAPGTPKANGSQPTGPGSPQPAL
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.  TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC).  The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13.  The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C.  TAF6 homodimer connects TFIID modules, forming a rigid core.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 6, Transcription initiation factor TFIID 70 kDa subunit, TAF(II)70, TAFII-70, TAFII70, Transcription initiation factor TFIID 80 kDa subunit, TAF(II)80, TAFII-80, TAFII80, p80.
What is the protein family that this protein belongs to?
Belongs to the TAF6 family.
What are the subcellular locations of this protein?
Nucleus.