PharMolix/UniProtQA huggingface dataset:
Protein: DXR_HELPH
Sequence: MVVLGSTGSIGKNALKIAKKFGVEIEALSCGKNIALINEQIKVFKPKKVAILDPSDLNNLEPLGAEVFVGLDGIDAMIEECVSNLVLNAIVGVAGLKASFKSLQRNKKLALANKESLVSAGNLLDISQITPVDSEHFGLWALLQNKTLKPKSLIISASGGAFRDTPLELIAIQNAQNALKHPNWSMGSKITIDSASMVNKLFEILETYWLFGTSLKIDALIERSSIVHALVEFEDNSIIVHLASADMQLPISYAIDPKLASLNASIKPLDLYALNAIKFEPISMERYTLWRYKDLLLENPKLGVVLNASNEVAMEKFLNQEIAFGGLIQTISQALELYAKKSFKLSSLDEVLELDKEVRERFENVAGV
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: SYK_METHJ
Sequence: MQDNPSIQFDDQRLAKRQQLIEAGVPMYPHEFRRSHTIAEIRAKYSQAGHDPSSDQVITAGRLYGVRDHGKTFFADLRDETGRIQLYIRKDALPEGKFQMFKSSIERGDIIGVTGRIFKTKVGEISIFVDDIILLTKTLCSLPEKFHGLTNLEKRYRQRYLDLIVNEESRETFRTRSRIISLLRNYLTGQGFLEFETPTLQPLYGGANARPFTTFHNFLGQKLYLRIAPELYLKRLVVGGFEKVFEVAKNFRNEDIDTSHNPEFSMVEIYQAYADYTDMMKLTEGIISSIVHEVTGSYEVAFEENTISYKAPWTVMSMEEAVRTIGKVDIFAHDLESLKKIGKEKGVDGIDDVHTQREMLVLFFEALVEDKLIQPTFITDFPVENSPLAKSHREKEGFVERFELFIAGMELANGFSELNDPLDQMERFEAQEEKRRLGDEEAQMHDYDFVNALGYGMPPTGGVGIGIDRLVMLITGNTSIKEVILFPSMKREVTTPADEEEPSSV
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_CAEEL
Sequence: MVPKPHAKSAKKALRKKKVHLKFNVECKNPVEDGILRIEDLEAFLNEKIKVNGKTGHLAANNVKVEVAKSKVSVVSEVPFSKRYLKYLTKKYLKRNSLRDWLRVVAVNKNTYEVRYFHINDGEDAGSDHE
What are the official names of this protein?
60S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL22 family.
Protein: SUCC_SOLUE
Sequence: MKIHEYQAKAILAQYKVPVPRGHVAYTEADAETAAKTLGGSVVVKAQIHAGGRGKGGGVKVAKDAAEALELAKKILGMTLVTHQTGPEGRLVQRLLIEETLPIERELYLGIVLDRVQGKPVFMASSAGGMDIEEVAAKTPELILKETLEYPGLSPYQARKLAFGIGIPAASVNAAAAAMTALSKAYWAMDASLAEINPFILTTDGKVYALDAKITFDDNALYRHKELVELRDLNEEDPLEVEASKHGLNYIKLDGTVGCMVNGAGLAMATMDIIKFAGGSPANFLDVGGGANAEQVKNAFRILLSDHSVKAVLINIFGGILRCDTLATGVVAAARDLNIQVPIVVRMEGTNVEAGRQILLESGFNFTVGADMWDAAQKVVKLAA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: GATB_LACP3
Sequence: MNFETTIGLEVHVELKTKSKMFSPSPVTYGQEPNTQTNVIDWGFPGVLPSINRGAYQLGIMVGLALHADITRLTHFDRKNYFYPDNPKAYQITQSEKPLGTNGWVEIEVDGKKKKIGIAELHVEEDAGKNQHEDDGYSYVDLNRQGTPLVEIVSKPDITSPEEAYAYLETLRQIVQFTGASDVKMEEGSMRVDTNLSVRPIGQEHFGIKTEIKNLNSFVHVRDGLAFEEKRQQAVLLSGGEVRQETRRWDPDAKETLLMRVKEGADDYRYFPEPDLPPVAVSQKWIDDIQASLPQPPAERRQRYIEDWGIPAYDAGVLTQTKEMSDFFEATVAQGADAKQASNWLMGEVSGFLNAQHVELGQVALTPAHLAGMIKLIGDGTISSKMAKKVFKEIIQHDTDPDKWVHEKGLIQLSDPAKLTPIIDEILDNNQQSIDDFKAGKDRAIGFLVGQIMKQTHGQANPKVVNQILMAEIKQR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: NQRA_YERE8
Sequence: MIKIKKGLNLPIAGAPVQVIEEGPDIHYVALLGEEYVGMRPSMLVQEGDWVKKGQALFEDKKNPGVMFTAPASGKVSAINRGERRVLQSVVIEIDGDEQVPFEHYEESSLNQLSDEQVQRHLLASGLWTALRTRPFSKTPVPNSRPRAIFISAMDTQPLAADPQVIIATESEAFNHGLTILARLTEGKVHVCHAPGQAVASYQNAQVTYNEFSGPHPAGLVGTHIHFLEPVSLNKTVWHVGYQDVIAIGKLFTRGELWTDRIVSLAGPQVEQPVLLRTRLGASLSELTTGRLKEGDNRIISGSVLSGTAFSATHGYLGRFHQQVSVIREGREKELFGWVMPGRDKYSITRTTLGHFFKHKLFAFSTDMHGGERAMVPIGNYERVMPLDILATHLLRDLLAGDTDSAAALGCLELDEEDLALCTFVCPGKYEYGPVLRDILTKIEQEG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit A, Na(+)-NQR subunit A, Na(+)-translocating NQR subunit A, NQR complex subunit A, NQR-1 subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrA family.
Protein: MURG_CHLTR
Sequence: MKKINKIVLAVGGTGGHIIPALAARETFIHEDIEVLLLGKGLAHFLGDDSEVAYCDIPSGSPFSLRVNRMFSGAKQLYKGYVAALQKIRDFTPDLAIGFGSYHSLPAMLASIRSRIPLFLHEQNIVPGKVNKLFSRFAKGVGMSFAAAGEHFHCRAEEVFLPIRKLSEQIVFPGASPVICVVGGSQGAKILNDVVPKALARIRESYSNLYVHHIVGPKGDLQAVSQVYQDAGINHTVTAFDHNMLGVLQASDLVISRSGATMLNELLWVQVPAILIPYPGAYGHQEVNAKFFTHTVGGGTMILQKYLTEESLSKQVLLALDPATSENRRKAMLSAQQKKSFKSLYQFICESL
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HFLD_THISH
Sequence: MDASQRNRVIALAALFQAASLVKDVAWHGRCDPDEFRTMVGSLFSFEASDVEGIYGNVHRLRRGLQALASQLENRGSGNDMELTRYVIGLLFLERKLMKQPHMIQGVREGIQGAERQRDYFDDPTHESVNAALAQTYQDTISQLGPRIIVQGEQAHLSNSDNAARIRTLLLSGIRAAVLWRQAGGSRWRLLFSRAGLLRETRALLAH
What are the official names of this protein?
High frequency lysogenization protein HflD homolog.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: WDR26_MOUSE
Sequence: MQANGAGGGGGGGGGGQGQTPELACLSAQNGESSPSATSAGDLAHANGLLPAAPSAAGNNSNSLSVNNGVPGGAAAASATAAAAQATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEISQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHAEDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRVRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS
What is the function of this protein?
G-beta-like protein involved in cell signal transduction.  Acts as a negative regulator in MAPK signaling pathway.  Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes.  Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity).  Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation.  Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration.  Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity).  Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
What are the official names of this protein?
WD repeat-containing protein 26.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion.
Protein: VG72_ICHVA
Sequence: MDGGMTVSDKGNWSFFGMASENKRPKWAAILSKAMGIQASFMTDQLRTAGPNPEGLISIHNSPDEALAVYSAHHTDGLNTCKICGHNVRDLKAHARQVHLGRLCKIENLAELGLAQTLRIDRDVEFAYIDGCYFWIGARAAPGLSRFFKPDATRCHRCPTVEWPDIENGESLEAVRLTGESPRLTDRARHLLAFHPGDFMASITTLISPKKSMNCEAIYSARGELQRFQLMWRGYGYKGERATAFPTKAVNEGFGTAVHEFLKMYDARTKALSVLPSDTKIYTVRFMEGEEPTTAVIPPGTHSVVPATTPAPEAPGKLNMSSPDLELIRRKGGKRVIEMVSGVAPSGSLVGAPSPSERVMKRKSERPLDDSSAVKRVSKKVTSVTDQECTAWESSIPGVSIERAPTIYTGKSAQTIAGVLTEGGVAPYPLIMDVDGERDLPIDLPNQIITGRVIESLGDLEGDIAARKEVIKKAVEALRVYSYRPLMQLSVIGIFFDEGWIYSVLEKPTGDLKTMSQTLRVLSTTGTFPWGGKSPAGTWKMAIVHHIFRDVVKLVALQNRLKVTPVFGKQDVYVWEHGLTIAPNSVEPRVDITGAQNLIISLLSQYTMFQHTTKLPIKPEVRATLSPDVLKLLDWPPRPPSSEVTEMAGRLGVMGDIGHPTIQFPLDFKIHMGSERVLRPDVLLIKPPKAAPSFYPSMEEVLRVLETPGPRSDESDEMVPASALISHATLAASQRGLVAAHASVGRAQAALSTRGGAFGATPSGEDATSALMKMIQELSNTSIPTSRSLLCELGLSSMRGPAVATPRPAEAPPSTSEGELFDVDAFLEKWTGPAPVEGTAPVPVEIPIVGDDIIRQSMALAGGECWELTETPSGNVVATGFTTPATPTIINPPSPHVFAVPMPPPANPGKRTKSVKRRIEAASKMEGGERDATGSSMDTVRGTGGLVTVKPQSLIRGDELGLMDKWVFEPALDTRTSSYLRGVHRTIVQRWLQNHGSMKPKMCRDPPTFAITDADVPILTTTPDATRRPICVDNNLPSTPMVFTWGDPNGSEPVPTEHRTSYELYRGDIQAAHQCNLYLGPSMEIYAYSPRVWIAQHTFDGANQIWGGFPPVIRYVYLNMMKIRPSKHIPYIYTVIEPHSVKGYKMNMYALITPMGHPVLTTGVAGYSKYLIKALVRTLHAVHSAGLKIGYMHPKNVWVKTDALGSDLQTYYIFDVVTQILENVFMPGSVGGRNAPVIPPEWTSKMTDNGPPLNLITEASDIFCLGRLLTVFCAQQDLTSEQVALIQLMCAAKPEERPCVTDLLVNFNVSPEEPFYPVDIGEMPVKITNTKKAERSNTAYVRFPVQGAQE
What are the official names of this protein?
Uncharacterized protein ORF72.
Protein: UPPP_BORPE
Sequence: MTDSTLHLLKAFFLGIVEGLTEFIPVSSTGHLIVIGDWINFASSSGKVFEVVIQFGSILAVMWIFRARLWQLIRGTLTGVRQEVNFTRNLLLAFLPAAVIGAIFIKSIKQVFYHPGVVAVTLVVGGFIMLWVERRAPHTPGDAPGAADDTASDERASAHTLEQISAKQALGVGVAQCVAMIPGVSRSGATIIGGMIAGIQRKTATEFSFFLAMPTMLGAAVYDLYRNIGLLSQHDMSAIAVGFVAAFLSALVVVRAVLRFVANHTYRVFAWYRIALGLVVAAWIYAK
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADA1D_MOUSE
Sequence: MTFRDILSVTFEGPRASSSTGGSGAGGGAGTVGPEGPAVGGVPGATGGSAVVGTGSGEDNQSSTAEAGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWPFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGNPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWPSLRPPLASLDRRPALRLCPQPAHRTPRGSPSPHCTPRPGLRRHAGGAGFGLRPSKASLRLREWRLLGPLQRPTTQLRAKVSSLSHKFRSGGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDLSNLRETDI
What is the function of this protein?
This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
What are the official names of this protein?
Alpha-1D adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoreceptor, Alpha-1D adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BEV1J_BETPN
Sequence: MGVFNYETEATSVIPAARLFKAFILDGDNLFPKVAPQAISSVENIEGNGGPGTIKKISFPEGFPFKYVKDRVDEVDHTNFKYSYSVIEGGPVGDTLEKISNEIKIVATPNGGSILKINNKYHTKGDHEVKAEQIKASKEMGETLLRAVESYLLAHSDAYN
What is the function of this protein?
May be a general steroid carrier protein.
What are the official names of this protein?
Major pollen allergen Bet v 1-J, Allergen Bet v I-J.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORR5_ORYSI
Sequence: MATCRSRGVERGGAPHVLAVDDSSVDRAVISGILRSSQFRVTAVDSGKRALELLGSEPNVSMIITDYWMPEMTGYELLKKVKESSRLKEIPVVIMSSENVSTRINRCLEEGAEDFLLKPVQPSDVSRLCSRVLR
What is the function of this protein?
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system.  Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes.  Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
What are the official names of this protein?
Two-component response regulator ORR5, Type A response regulator 5, OsRR5.
What is the protein family that this protein belongs to?
Belongs to the ARR family. Type-A subfamily.
Protein: RAN2_ORYSI
Sequence: MALPNQGTVDYPSFKLVIVGDGGTGKTTFVKRHLTGEFEKKYEPTIGVEVHPLDFTTNCGKIRFYCWDTAGQEKFGGLRDGYYIHGQCAIIMFDVTSRLTYKNVPTWHRDLCRVCENIPIVLCGNKVDVKNRQVKAKQVTFHRKKNLQYYEISAKSNYNFEKPFLYLARKLAGDPNLHFVEAVALKPPEVPIDLAMQQQHEAELAAAAAQPLPDDDDDLIE
What is the function of this protein?
GTP-binding protein involved in nucleocytoplasmic transport.  Required for the import of protein into the nucleus and also for RNA export.  Involved in chromatin condensation and control of cell cycle (By similarity).
What are the official names of this protein?
GTP-binding nuclear protein Ran-2, OsRan2, Ras-related nuclear protein 2.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y2181_BURO1
Sequence: MRIVLITGISGSGKSVALNALEDAGYYCVDNLPPHVLPELARYLAQDGQRRLAVAIDARSSASLDEMPGLIRELSREHDVRVLFLNASTQALIQRFSETRRRHPLSGSRSHDADVGLLSSLEEAIERERELVAPLAEFGHQIDTSTLRANALRTWVKRFIEQKNNDLMVMFESFGFKRGVPLDADLMFDVRALPNPYYDHQLRPLTGLDQPVIAFLDALPIVHQMIDDIHAFLMKWLPHFRDDNRSYLTVAIGCTGGQHRSVFIAETLAARLARDANVIVRHRDAPVDVDASSRLVSEVDRP
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein Bcen_2181.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: NR1H3_BOVIN
Sequence: MSLWLEAPVPDVSPDSAVELWEPDAQDASSQPLGSSKCILREESSTPQSAGDTSRMGLEAPEPTALLPGVEAPPESTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKMKRQEEEQAQATSAPPRASSPPQVLPQLSPEQLGMIEKLVAAQQLCNRRSFSDQLRVTPWPMAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
What is the function of this protein?
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity.  Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES.  LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides.  Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.  Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).  Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity).  Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity).  Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity).
What are the official names of this protein?
Oxysterols receptor LXR-alpha, Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: HRG1_MOUSE
Sequence: MAPSRLQLGLRAAYSGFSSVAGFSIFFVWTVVYRQPGTAAMGGLAGVLALWVLVTHVMYMQDYWRTWLRGLRGFFFVGALFSAVSVSAFCTFLALAITQHQSLKDPNSYYLSCVWSFISFKWAFLLSLYAHRYRADFADISILSDF
What is the function of this protein?
Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
What are the official names of this protein?
Heme transporter HRG1, Heme-responsive gene 1 protein homolog, HRG-1, Solute carrier family 48 member 1.
What is the protein family that this protein belongs to?
Belongs to the HRG family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein.
Protein: YVOD_BACSU
Sequence: MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVRLITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLIIESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWLGMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTSMTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIPVWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI
What are the official names of this protein?
Uncharacterized membrane protein YvoD.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAS5A_SACS2
Sequence: MIYSKVFLKLHWGFSVVKPLAAKAKPGFYLPPPTTLIGALSYGKFRGVDNINLGNVYGSPAYNFRNIMATARLESEGVYTEDIIRNVISYFQRKERRENPRYIYGVIPTGKVYIPNGRLVVVYVTDSISKEELEKLCWSITRIGCKECLASVENVEVGEAKKVSGRVKTRYYFRDTVKVVGRKEFLEYVTFWEENGYIWGKEGSPVRYILPITTYPLASKEVEVEAKEAYEVGGEYVVFS
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
What are the official names of this protein?
CRISPR system aCascade subunit Cas5 1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
Protein: DUT_TREPS
Sequence: MIRVRAVVYPGASFPEYQTLGSSGADLRAFLPGGPLEVHPLGRVLVPTGVCVELPVGLEMQIRPRSGLALEYGVTVLNSPGTIDADYRGEIRVLLVNLGLAAFVVSHGDRIAQAVISSVLRVEYVRSGSISLTERGKGGYGSTGVL
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: TFE_META3
Sequence: MLNNPIIQQVLLEILGDDINGFNVLEALTELTEVTDDEISRQLDLKLNTVRKLLYKLYDARLVDYNREKDEETNWYSYTWRATFTKLPGVVKKRMEQLLIDLKEQLEVEENTLFFYCPRCEFKYSFDEAIDYGFRCSQCNGVLKEYNNKNDILMIKNQIKIIEEELALNPLFS
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: RISB_KLEP3
Sequence: MNIIEANVATPDARVAITIARFNNFINDSLLEGAIDALKRIGQVKDENITVVWVPGAYELPLAAGALAKTGKYDAVIALGTVIRGGTAHFEYVAGGASNGLAHVAQDSEIPVAFGVLTTESIEQAIERAGTKAGNKGAEAALTALEMINVLKAIKA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: PHS_LEGPC
Sequence: MTSDLSSKHCESCEGIGAALNSEQIKNLLPQLNTKWEVTEDNRIIKRAFSFKNFYETMAFVNAIAWIANIENHHPDLEVGYNYCRVHFMTHALNGLTHNDFICAAKIDKLLVD
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: PFDB_METPE
Sequence: MSAISPKIQNQIAMLQQVQQQMQTIMSQKTQYEMEIRENRRAEEELNDVPQESAVFMNVGTVMMQKPKEKVIASLQEKAESLELRVKSLEKQEKMMQAKFEQLQAQVKEALEGGNRPPNAA
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRXB_PNEJI
Sequence: MHSKVIIIGSGPAGHTAAIYLARAELKPVLYEGMLANGIAAGGQLTTTTDVENYPGFPDGIMGPLLMEKFREQSVKYGTCIITETVSKLDLSKRPFKYWCESDENTCHTADVVVMATGAYARRLHIPGEETYWQRGISACAVCDGAAPIFRGKCLSVVGGGDSAAEESLFLTRYATKVYLLVRRDKLRASAVMAKRLLNHPKIEVIWNTVVLRSLGDGHLLNRLEIKNVKTQVVSELHVSGLFYAIGHEPATALVRGQVECDDNGYIITKNGGPETNIKGFFAAGDVQDKKWRQAVTSAGSGCMAGLAAERLLAEEEEMKNIEKNKK
What is the function of this protein?
Component of the thioredoxin-thioredoxin reductase system which may be involved in biosynthesis of penicillins and cephalosporins and may be important in determining the thiol-disulfide redox balance.
What are the official names of this protein?
Thioredoxin reductase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YXJI_BACSU
Sequence: MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMTDSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLWRDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDESIF
What are the official names of this protein?
Uncharacterized protein YxjI.
What is the protein family that this protein belongs to?
Belongs to the LOR family.