PharMolix/UniProtQA huggingface dataset:
Protein: SAS2_SPOUR
Sequence: MPNNNSSNQLLVPGVQQALNQMKEEIASEFGVQLGPDASSRANGSVGGEITKRLVRQAQSQMNGYTK
What is the function of this protein?
SASP are bound to spore DNA.  They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation.  They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.
What are the official names of this protein?
Small, acid-soluble spore protein 2, SASP.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta-type SASP family.
Protein: NU4M_PROFL
Sequence: PIAGSMVLAAILLKLGGYGIIRMMQVLPPTKTDMFLPFIVLALWGAILANLTCLQQTDLKSLIAYSSISHMGLVVAAIIIQTPWGLSGAMALMIAHGFTSSALFCLANTTYERTHTRILILTRGFHNILPMTTTWWLLTNLMNIATPPSLNFTSELLIMSSLFNWCPTTIILLGLSMLITASYSLHMFLSTQTGPTLLDNQTEPTHSREHLLMALHIIPLMMISMKPELII
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: PROQ_SHIBS
Sequence: MENQPKLNSSKEVIAFLAERFPHCFSAEGEARPLKIGIFQDLVDRVAGEMNLSKTQLRSALRLYTSSWRYLYGVKPGATRVDLDGNPCGELDEQHVEHARKQLEEAKARVQAQRAEQQAKKREAAAAAGEKEDAPRRERKPRPTTPRRKEGAERKPRAQKPVEKAPKTVKAPREEQHTPVSDISALTVGQALKVKAGQNAMDATVLEITKDGVRVQLNSGMSLIVRAEHLVF
What is the function of this protein?
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.  May regulate ProP activity through an RNA-based, post-transcriptional mechanism.
What are the official names of this protein?
RNA chaperone ProQ.
What is the protein family that this protein belongs to?
Belongs to the ProQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHCA_ARTPT
Sequence: MKTPLTEAVSIADSQGRFLSSTEIQVAFGRFRQAKAGLEAAKALTSKADSLISGAAQAVYNKFPYTTQMQGPNYAADQRGKDKCARDIGYYLRMVTYCLIAGGTGPMDEYLIAGIDEINRTFELSPSWYIEALKYIKANHGLSGDAATEANSYLDYAINALS
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex (phycobilisome, PBS).  Phycocyanin is the major phycobiliprotein in the PBS rod.
What are the official names of this protein?
C-phycocyanin alpha subunit.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Part of the phycobilisome rod.
Protein: RF1_CYTH3
Sequence: MVDKLEAIKSRFDEVAEAILDPNIMSDMKRYASLNKEYKELNKIVEVYAQYKNILDNIESSKKVLSVEKDPDFREMAKEELETLAVQKDDIELVIKELLIPKDPNDSKNIILEIRGGTGGDEASIFAGDIFRMYQRYCDRMGWKMELIDATEGTSGGYKEIICGISGEDVYGKLKFESGVHRVQRVPATETQGRIHTSAASVAVLPEVEELDVQLNMNDIRKDTFCSSGPGGQSVNTTYSAIRLTHIPSGTVVQCQDEKSQIKNFEKALKVLRSRIYEIEYKKQQDELGKERNSMIGSGDRSDKIRTYNYPQSRVTDHRIGHTVHNLPAVMDGNIDDFIEELRLAENAERLKEGAQETA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P5CR_METAC
Sequence: MENQKIGFIGAGKMGSALMQGTIKAGIVTPENIGASDVYEPFLKDLQAKLGIRVSTDNAVIVRESDILILAVKPQTLSSVLSNLKNEITSEKLVISIAAGVPLSTYEDALLEGTRVVRVMPNIAATVSEAASGIAPGKNATPEDLKAALEIFSAVGTAVQVPESLMDAVTGLSGSGPAFIFPVIEAMADGAVLEGMDRKSALTLAAQTVLGAAKMALETGMHPGELKDMVTSPAGTTIQGIHSLEEAGIRAAFMNAVIRASERSKELGKK
What is the function of this protein?
Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
What are the official names of this protein?
Pyrroline-5-carboxylate reductase, P5C reductase, P5CR, PCA reductase.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_RHOPS
Sequence: MSKVGTSDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKSSLVKSRDGIPTPKEICKVLDDYVIGQGHAKKVLSVAVHNHYKRLNHQTKHNDVELAKSNILLIGPTGSGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIILKLLQAADYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLEKIISARGRSTSIGFAAQVLAPEDRRTGEIFRHVEPEDLLKYGLIPEFVGRLPVVATLEDLDEASLKKILTDPKNALVKQYQRLFEMENIELTFADEALGAVARKAIERKTGARGLRSILESILLETMFDLPGLEGVEEVVISREVVDGTARPLYIYADRSDRAAESSASA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: VPU_HV1EL
Sequence: MQPLGIIAIAALVVAIILAIVVWTIVFIEYRRIKKQRRIDCLLDRITERAEDSGNESEGDREKLSKLVEMGHHAPWDIDDL
What is the function of this protein?
Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo.
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: APU_THEP3
Sequence: MFKRRTLGFLLSFLLIYTAVFGSMPVQFAKAETDTAPAIANVVGDFQSKIGDSDWNINSDKTVMTYKGNGFYEFTTPVALPAGDYEYKVALNHSWEGGGVPSQGNLSLHLDSDSVVTFYYNYNTSSVTDSTKYTPIPEEKLPRIVGTIQSAIGAGDDWKPETSTAIMRDYKFNNVYEYTANVPKGYYEFKVTLGPSWDINYGLNGEQNGPNIPLNVAYDTKITFYYDSVSHNIWTDYNPPLTGPDNNIYYDDLKHDTHDPFFRSPFGAIKTGDTVTLRIQAKNHDLESAKISYWDDIKKTRTEVPMYKIGQSPDGQYEYWEVKLSFDYPTRIWYYFILKDGTKTAYYGDNDEQLGGVGKATDTVNKDFELTVYDKNLDTPDWMKGAVMYQIFPDRFYNGDPLNDRLKEYSRGFDPVEYHDDWYDLPDNPNDKDKPGYTGDGIWNNDFFGGDLQGINDKLDYLKNLGISVIYLNPIFQSPSNHRYDTTDYTKIDELLGDLDTFKTLMKEAHARGIKVILDGVFNHTSDDSIYFDRYGKYLDNELGAYQAWKQGDQSKSPYGDWYEIKPDGTYEGWWGFDSLPVIRQINGSEYNVKSWADFIINNPNAISKYWLNPDGDKDAGADGWRLDVANEIAHDFWVHFRAAINTVKPNAPMIAELWGDASLDLLGDSFNSVMNYLFRNAVIDFILDKQFDDGNVVHNPIDAAKLDQRLMSIYERYPLPVFYSTMNLLGSHDTMRILTVFGYNSANENQNSQEAKDLAVKRLKLAAILQMGYPGMPSIYYGDEAGQSGGKDPDNRRTFSWGREDKDLQDFFKKVVNIRNENQVLKTGDLETLYANGDVYAFGRRIINGKDVFGNSYPDSVAIVVINKGEAKSVQIDTTKFVRDGVAFTDALSGKTYTVRDGQIVVEVVALDGAILISDPGQNLTAPQPITDLKAVSGNGQVDLSWSAVDRAVSYNIYRSTVKGGLYEKIASNVTQITYIDTDVTNGLKYVYSVTAVDSDGNESALSNEVEAYPAFSIGWAGNMNQVDTHVIGVNNPVEVYAEIWAEGLTDKPGQGENMIAQLGYRYIGDGGQDATRNKVEGVEINKDWTWVDARYVGDSGNNDKYMAKFVPDMVGTWEYIMRFSSNQGQDWTYTKGPDGKTDEAKQFIVVPSNDVEPPTALGLQQPGIESSRVTLNWSLSTDNVAIYGYEIYKSLSETGPFVKIATVADTVYNYVDTDVVNGKVYYYKVVAVDTSFNRTASNIVKATPDIIPIKVIFNVTVPDYTPDDGANIAGNFHDAFWNPSAHQMTKTGPNTYSITLTLNEGTQLEYKYARGSWDKVEKGEYGEEIANRKITVVNQGSNTMVVNDTVQRWRDLPIYIYSPKDNTTVDANTNEIEIKGNTYKGAKVTINDESFVQQENGVFTKVVPLEYGVNTTKIHVEPSGDKNNELTKDITITVIREEPVQEKEPTPTPESEPAPMPEPQPTPTPEPQPSAIMAL
What are the official names of this protein?
Amylopullulanase, Alpha-amylase/pullulanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: MEND_LACLA
Sequence: MTNEYLAPFVDELFNLGVREAVFSPGSRSTALAMLFEEYKKYDTYVNIDERSAAFFALGIAKAKKRPVVLVCTSGSAAAHHFPAVLEAKMSRVPLIILTADRPAELQFVGAPQTVDQTRFFGNFVNHFENLEAPHIQKQSQTENFWTYPRKVAQRAVLSAISPLSGPVQINVPLRDLLVPELKSENYEKGRSKHAFKFYEGQAQVILPFDEALLSGKTLILAGANFDKDYSEALLKLAEQLKAPILADPLSNLRNHNHPLVIDSYDAFLANNDLKTQLKADAILLFGQMPVSKRLQQFVAFNNEAEFIQVDPALDYRNPSLTTTTMVQSDVLPFASSIKKVNSDSSYLEKWQNAQEKMRQLLEKVTYEESPFEGRYVQELQKHLEALDAQLLVSNSMEIRDIDYWWKKADAKVRILGNRGVNGIDGTESTALGIATTGKPTVLLTGDLSMLHDLNGLIVGKTHELNLTIVLFNNDGGGIFHHLAQKGVPNFDYLFSTPHGLNFAGLAELTGLDYHLVSGYADFGQQFEASLHQSGIHLLEIKTDKDLSLALHQKYTTYEN
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: UBIE_ZYMMO
Sequence: MEKVSFGFSDVSPQEKTHLVGDVFRRVASRYDLMNDAMSGGLHRLWKDDFVRLVQPKASEHILDMAGGTGDIAFRLAKYGTNVTIADINPAMLEVGKKRAIARSIENLTWKEENAEALSFNDNVFDAYTIAFGIRNVTHIQKALDEAWRVLKVGGRFFCMEFSQTKWSGFSNLYKMYSTHIVPKIGQLLANDEDSYRYLIESIERFPNIEKFSDMIKSAGFVQIRARPILGGLVAIHSGWKV
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RNC_FUSNN
Sequence: MKNLLDLEHKLNYYFNDRNLLKNALLHKSLGNERKEYKNQTNERLELLGDAVLDLIVAEYLYKSYKNASEGPIAKLKAMIVSEPILAKISRQIGVGKFLMLSRGEVMSGGRNRESILADSFEAILGAVYIDSNLDEARVFALSHIKQYIDHIEENEDILDFKSILQEYVQKEFKTVPTYELVAERGPDHMKEFEIQVIVGNYKEKAVARNKKKAEQLSAKALCIKLGVKYNEAL
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBT6_ARATH
Sequence: METLETEKFFSDDKPLLKPISDHSEIKTKARRNAVVSVLIQPFQWLQMLSSRLNLSFVLGVVLVYGVNQGFSGSIFKVVTDYYWKDVQQVQPSVVQLYMGLYYIPWVMRPIWGLFTDVFPIKGYKRKPYFVVSGVLGLVSAIAIVVLGKLPAALALSCLLGVSAAMAIADVVIDACIATNSINIRSLAPDIQSLCMVCSSAGALVGYATSGVFVHQLGPQGALGVLAFSPATIVILGFFIYEKRSSTVPTQKTKKDTDGLGVAVKGMCKTVKYPEVWKPSLYMFISLALNISTHEGHFYWYTDPTAGPAFSQEFVGIIYAVGALASMFGVLIYHKKLKGYSFRNILFFAQLLYVFSGMLDLVFIKRWNLTLGIPDSLFVITEESFTKMISKIRWIPMVVLSTRLCPLGIEGTFFAFLMCIDSFGQLASKWGGGFVLHAFGVTRHDFGNLWLVILIRNILRLVTVCFVFLVPDSDHLDDLVPSDVLPKKQSEDDDDDDIKLLLL
What is the function of this protein?
Could mediate folate transport.
What are the official names of this protein?
Probable folate-biopterin transporter 6.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AQP2_SHEEP
Sequence: MWELRSIAFSRAVLAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLAIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAVFYVAAQLLGAVAGAALLHEITPPAIRGDLAVNALNNNSTAGQAVTVELFLTLQLVLCIFPSTDKRRGKQLGHPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAIVTGKFDDHWVFWIGPLVGAIVASLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
What are the official names of this protein?
Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
Protein: PAND_CITK8
Sequence: MIRTMLQGKLHRVKVTQADLHYEGSCAIDQDFLDAAGILENEAIDIWNVTNGKRFSTYAIAAERGSRIISVNGAAAHCAAVGDIVIIASFVTMSDEEARRWQPNVAYFEGDNEMKRTAKAIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBK_MYCTU
Sequence: MTRVLLLGGTAEGRALAKELHPHVEIVSSLAGRVPNPALPIGPVRIGGFGGVEGLRGWLREERIDAVVDATHPFAVTITAHAAQVCGELGLPYLVLARPPWDPGTAIIAVSDIEAADVVAEQGYSRVFLTTGRSGIAAFANSDAWFLIRVVTAPDGTALPRRHKLVLSRGPYGYHDEFALLREQRIDALVTKNSGGKMTRAKLDAAAALGISVVMIARPLLPAGVAAVDSVHRAAMWVAGLPSR
What is the function of this protein?
Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
What are the official names of this protein?
Precorrin-6A reductase, Precorrin-6X reductase.
What is the protein family that this protein belongs to?
Belongs to the precorrin-6x reductase family.
Protein: ERA_STAHJ
Sequence: MTEHKSGFVSIIGRPNVGKSTFMNRVIGHKIAIMSDKAQTTRNKIQGVMTRNDAQIIFLDTPGIHKPKHKLGDYMMRVAKNTLSEIDAIMFMVNVNEEIGRGDEYIMEMLKNVKTPVFLVLNKIDLVHPDALMPRIEQYQKYMNFTEIVPISALEGLNVDHFIDVLKTYLPEGPKYYPDDQISDHPEQFVVSEIIREKILHLTSEEIPHAIGVNVDRMIKENDERVRVEATIYVERDSQKGIVIGKGGKKLKEVGKRARHDIEMLLGSKVYLELWVKVQKDWRNKVNFIRQMGYIEDQD
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: SECA_LACLS
Sequence: MPNIIRKLVENDKKELKKLNKMALQVESFADEMEHLTDEQLKAKTPELKERIAKGESLDDLLYEAFAVCREAARRVLGLYPFHVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNALSGKGVHVVTVNEYLATRDMTEMGELYSWLGLTVGLNLNSKSPEEKREAYNCDITYSTSAELGFDYLRDNMVTRAVDMVQKPLNYALVDEVDSILVDEARTPLIISGQAESSSALYYRADQFTKTLKGQNLNVATSDYEEGDDYKIDLQSKTISLTEEGIDKAEKFFQIENLYDMENVALTHFVDNALRANFIMLHDIDYMVDENQEVLIIDQFTGRTMPGRRYSDGLHQAIEAKEAVPIQDESKTMASITIQNYFRMYKKLSGMTGTAKTEEEEFREIYNIQITPIPTNRPVQRLDHPDLLYPTLEAKFKAVIDDIKRRHAEGQPILIGTVAVETSELISKKLVEAKIPHEVLNAKNHFREAQIIMNAGQQGAVTIATNMAGRGTDIKLGPGVIDHADPEFRGLAVIGTERHESRRIDNQLRGRSGRQGDPGVSQFYLSLEDELMKRFGSERVSAFLDRMRISGEDAVIKSGLITRQIESSQKRVEGNNYDSRKQVLQYDDVIREQREVIYAQRQEVILTKEDMTPVLMGMFKRTIDRQVDGHELAGNLKDEETVKDLLQTVQNTMLPEEAIELSELTGLSGQAMKDLIFDKVKSRYASQMEKLADPERQLEFQRAVILRVVDNNWSEHIDALDQMRQSVGLRGYAQNNPIVEYQEESYKMYNNMIGAIEFEVTRLMMKAQIQPQTAIRQEAPRMTTTASQENITNVGPDTSVSEEISFENVGRNDPCPCGSGKKFKNCHGRTHIA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50.
Protein: DDL_CERS4
Sequence: MAGQSGRTFPRVAVLMGGASTEREVSLSSGHSCSAALRDAGYEVTEVDAGPDLARVLAELSPDAVFNALHGRWGEDGCVQGLLEWLRIPYTHSGVLASALAMDKARAKEVFAAAGLPVTQSVLATPEEVRARHILPPPYVVKPNAEGSSVGVYIVHEDANGPPQLAADMPQDLMVETYVPGRELTVTVMGDRVLAVTDILSDGWYDYDAKYRPGGSRHIVPADLPAEITEACHDIALRAHRALGCRGISRSDLRWDEARGLAGLILLETNTQPGMTPTSLSPEQAAHCGYSFPEFCAWLVEDASCSR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYY2_HUMAN
Sequence: MATVLLALLVYLGALVDAYPIKPEAPGEDAFLG
What are the official names of this protein?
Putative peptide YY-2, Putative peptide YY2.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAY_CHLPM
Sequence: MLYYLLKYINEVFDPPGLGVIEYLTFRASAAAITALLITLVAGPGFIALLRARFIEPVKEEAPPEHRKKKLPTMGGLLIIISVEVSVLLWAKFTDPHVWLIMLALLWMGVIGFIDDYSKVVLKVKGGLSARWKLVGQISLGLVVGIYTSMDPVFSVLMRETTVPFFKNLTIDYGIFYVPVVIFIITALSNAVNLTDGLDGLAAGSSAIVIFGLGGFAYLAGNVVYASYLSIPFIPGGGEIAVVCMAATMACVGFLWFNANPAEIIMGDTGSLALGSTIAVTALLIKQELLLPVLGGLFFLETLSVSLQVLYFKYTRMRFGEGRRIFLMAPLHHHFQLKGWAEQKIVIRFWIVTILLFLTSLMTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FTSL_NEIMB
Sequence: MAMNKLNFLLLLAVCVSAFSVVMQQNQYRLNFTALDKAKKQEIALEQDYAQMRLQQARLANHEAIRAAAEKQNLHPPVSGNTFMVEHQR
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsL.
What is the protein family that this protein belongs to?
Belongs to the FtsL family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum where it forms a ring structure.
Protein: EFCB3_BOVIN
Sequence: MAVSEIKAKFKLNPLTKVPNFHSRRDKDLPGLLPCQLQHKERKLSPSQMRAFQDAYNFFNKDKTGCIDLHGMMCTLAKLGMNLTKHDVHNELRCADIDQDGKVNFSDFLKVLTDKNRFLKAVVPEKGTCLDLAGNPGILLFEILSKLIETSALPKKAISEIVSYFRRKFQETTSGMVWSPDTTGYGKRRFKPDICTPPSSSTAAFANAARIAIMKEKDLFKFLDELKKCNPPSDSPYSKIPIFPLFPNVDGVVMGKPFKDIQKLEMLKRKEPLNFFENYFFHKKDWKTQEANIKPVDPTSGYTTDILTIDQMLKRKQNWTVADAAAIKPHVKRATETYNLGIALEHRKQMLNLWRKIRGDLIGIESKNESFYDTFSTYTWSWNVCQELLSPKDLKLYDAHVNRNALHNSVFSSSSDISECDTDTGRKRKRKGFKGFRQ
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 3.
Protein: Y6044_DICDI
Sequence: MIKKAMLLIMLYMVLVVNDLILYNILSKAIIKKSKNVWKLKHKPLKNINLETLKNY
What are the official names of this protein?
Putative uncharacterized protein DDB_G0280563.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AROA_CAUSK
Sequence: MTAAGLKSTPGGPLRGTVRAPGDKSISHRSMILGALASGTTTVEGLLEGADVLATAQAMRSFGARVEQEGVGRWRIEGQGGFLEPSDVVDCGNAGTGVRLIMGAAAGFPLCATFTGDGSLRSRPMSRVLDPLARMGATWLGRDKGRLPLTLKGGNLRGLQYTLPMASAQVKSAVLLAGLHAEGGVEVIEPEATRDHTERMLRAFGAEVIVEDQGGVRHIRLPAGQKLTGTHVAVPGDPSSAAFPLVAGLIVPGSEVTVEGVMLNELRTGLFTTLREMGADLVISNVRESSGEEVGDITARYSRMHGVVVPPERAPAMIDEYPILAVAAAFATGDTVMRGVGEMRVKESDRIALTAAGLEACGVDVEEEPEGFIVHGTGQAPRGGAMVETHGDHRIAMSHLILGLAAQSAVSIDEPGMIATSFPGFAEMMRGLGGDLVEA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCGF1_HUMAN
Sequence: MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSRWFGKPSPLLLQYSVKEKRR
What is the function of this protein?
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A.  Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway.  Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element).  Promotes cell cycle progression and enhances cell proliferation as well.  May have a positive role in tumor cell growth by down-regulating CDKN1A.  Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.  PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332).  Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).  Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).
What are the official names of this protein?
Polycomb group RING finger protein 1, Nervous system Polycomb-1, NSPc1, RING finger protein 68.
What are the subcellular locations of this protein?
Nucleus.