PharMolix/UniProtQA huggingface dataset:
Protein: TERF2_HUMAN
Sequence: MAAGAGTAGPASGPGVVRDPAASQPRKRPGREGGEGARRSDTMAGGGGSSDGSGRAAGRRASRSSGRARRGRHEPGLGGPAERGAGEARLEEAVNRWVLKFYFHEALRAFRGSRYGDFRQIRDIMQALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRLVLEEDSQSTEPSAGLNSSQEAASAPPSKPTVLNQPLPGEKNPKVPKGKWNSSNGVEEKETWVEEDELFQVQAAPDEDSTTNITKKQKWTVEESEWVKAGVQKYGEGNWAAISKNYPFVNRTAVMIKDRWRTMKRLGMN
What is the function of this protein?
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes.  In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo.  Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection.  Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.  Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair.  Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo.  Preferentially binds to positive supercoiled DNA.  Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology.  Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.
What are the official names of this protein?
Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Protein: ASAH2_RAT
Sequence: MAKRTFSSLEAFLIFLLVMMTAITVALLTLLFVTSGTIENHKDSGNHWVSTTQGPTTTQSSPTTQTPTTQTPDLPPSQNFSGYYIGVGRADCTGQVSDINLMGYGKNGQNAQGLLTRLFSRAFILADPDGSNRMAFVSVELCMISQRLRLEVLKRLQSKYGSLYRRDNVILSATHTHSGPAGFFQYTLYILASEGFSNRTFQYIVSGIVKSIDIAHTNLKPGKVLINKGNVANVQINRSPSSYLQNPPSERARYSSDTDKEMVVLKLVDLNGEDLGLISWFAVHPVSMNNSNHLVNSDNMGYAAYLFEQEKNRGYLPGQGPFVAGFASSNLGDVSPNILGPHCVNTGESCDNDKSTCPSGGPSMCMASGPGQDMFESTHIIGRVIYQKAKELHASASQEVTGPVLTAHQWVNMTDVSVQLNATHTVKTCKAALGYSFAAGTIDGVSGLNITQGTTEGNLFWDTLRDQLLGKPSEEIIECQKPKPILIHTGELTKPHPWQPDIVDIQIVTLGSLAIAAIPGEFTTMSGRRLREAVKKEFALYGMKDMTVVIAGLSNVYTHYITTYEEYQAQRYEAASTIYGPHTLSAYIQLFRALAKAIATDTVANMSSGPEPPFFKNLIGSLIPNIADRAPIGKQFGDVLQPAKPEYRVGEVVEVVFVGANPKNSAENQTHQTFLTVEKYEDSVANWQIMHNDASWETRFYWHKGVLGLSNATIHWHIPDTALPGVYRIRYFGHNRKQELLKPAVILAFEGISSPFEIVTT
What is the function of this protein?
Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:11328816, PubMed:10488143, PubMed:15217782).  Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:11328816).  Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:15123644, PubMed:11278489).  Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:15217782).  Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells.  This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity).
What are the official names of this protein?
Neutral ceramidase, N-CDase, NCDase, Acylsphingosine deacylase 2, N-acylsphingosine amidohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the neutral ceramidase family.
What are the subcellular locations of this protein?
[Neutral ceramidase]: Cell membrane; Single-pass type II membrane protein. Membrane raft; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Mitochondrion. Secreted, extracellular exosome. Note=Enriched in exosomes upon stimulation by cytokine (By similarity). Enriched in caveolae and lipid rafts (By similarity). The localization to the mitochondrion could not be confirmed (By similarity). SUBCELLULAR LOCATION: [Neutral ceramidase soluble form]: Secreted.
Protein: ATBP_STAAU
Sequence: MTKNQNFIETKEYKRFAEFCDACIKYQYIGICYGQPGVGKTLSSRYYTNWNTIEKQVNHRGWEDLASKTTDDILSVNKIFYTRPAEKQTRLSNDLYSISASIDLGQKLHIVNKYGHDHSKHYSDMFKYIDLIIVDEIDRLKVQHLEQLRAIYDEHNLAMIFIGMPGIEKKLSRYPQLYSRIGFAHEFDNLSKDETHHILEYKWQDLGFDLKLEDFTDYEAITTIIKITKGNFRLIHRLFAQIDRIMDINGLDKISTEVVETARDSLVIGIR
What are the official names of this protein?
Potential ATP-binding protein, ORF 271.
Protein: VSP_ECHOC
Sequence: MVLIRVLANLLVLQLSYAQMSSELVVGGGECNRNRHRSLALLYNSSGTLCGGTLIHEEWVLSAAHCDMENMKIYLGLHNLSLPNKDQQKREPRETHFCLPSRNYTLWDKDIMLIKLNRPVNNSPHIAPISLPSNPPRLRSVCHIMGWGAITSPNETYPDVPHCANINILRYSVCRAAFGRLPAQSRTLCAGILRGGIDTCLGDSGGPLICNGQIQGIVSWGAEVCAKPHAPGLYTKVSDYTDWIQSIIAGNTTATCPP
What is the function of this protein?
Snake venom serine protease that may act in the hemostasis system of the prey.
What are the official names of this protein?
Serine protease sp-Eoc49, Snake venom serine protease, SVSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RGI2_YEAS1
Sequence: MTKKDKKAKGPKMSTITTKSGESLKVFEDLHDFETYLKGETEDQEFDHVHCQLKYYPPFVLHDAHDDPEKIKETANSHSKKFVRHLHQHVEKHLLKDIKTAINKPELKFHDKKKQESFDRIVWNYGEETELNAKKFKVSVEVVCKHDGAMVDVDYRTEPLQPLI
What is the function of this protein?
Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.
What are the official names of this protein?
Respiratory growth induced protein 2.
What is the protein family that this protein belongs to?
Belongs to the RGI1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUI1_METST
Sequence: MKICEICGLPKDLCVCEEIAREVQKVKVYTVRRRFGKLMTIVEGIDEHDIDIRELTKTLKSKCACGGTSKKGQIELQGDHKRKVKEVLAGMGFSSDTIEIK
What are the official names of this protein?
Protein translation factor SUI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: NDHH_JASNU
Sequence: MIAPTTRKDLMIINMGPHHPSMHGVLRLIITLDGEDVIDCEPILGYLHRGMEKIAENRTILQYLPYVTRWDYLATMFTEAISVNGPEQLGNIQVPKRASYIRTIMLELSRIASHLLWLGPFMADIGAQTPFFYIFREREFIYDLFEAATGMRMMHNFFRIGGIAADLPHGWIDKCLDFCDYFLRGVVEYQKLITRNPIFLERVEGVGIIGAEEALNWGLSGPMLRASGIQWDLRKMDHYECYDEFDWEVQWQKEGDSLARYLVRISEMTESIKIIQQALERIPGGPFENLEIRRFDRIKDTEWNDFEYRFISKKPSPTFELSKQELYVRVEAPKGELGIFLIGDQSVFPWRWKIRPPGFINLQILSQLVKRMKLADIMTILGSIDIIMGEVDR
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, chloroplastic, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase 49 kDa subunit, NADH-plastoquinone oxidoreductase subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: SODM_ASPOR
Sequence: MATTFSLPPLPYAYDALEPVICKQIMEIHHQKHHQTYITNLNAALSAQSTALAANNIPQLINLQQKIKFNGGGHINHSLFWKNLAPHASPETNIDQAAPVLKAAIEAQYGSVEKFKEAFGATLLGLQGSGWGWLVANGPGGKLEIVSTKDQDPVTDKVPVFGVDMWEHAYYLQYFNNKASYVEGIWKVLNWRTAEDRFKNGVEGSALLKL
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Superoxide dismutase [Mn], mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: Y2005_MYCTO
Sequence: MSKPRKQHGVVVGVDGSLESDAAACWGATDAAMRNIPLTVVHVVNADVATWPPMPYPETWGVWQEDEGRQIVANAVKLAKEAVGADRKLSVKSELVFSTPVPTMVEISNEAEMVVLGSSGRGALARGLLGSVSSSLVRRAGCPVAVIHSDDAVIPDPQHAPVLVGIDGSPVSELATAVAFDEASRRGVELIAVHAWSDVEVVELPGLDFSAVQQEAELSLAERLAGWQERYPDVPVSRVVVCDRPARKLVQKSASAQLVVVGSHGRGGLTGMLLGSVSNAVLHAARVPVIVARQS
What are the official names of this protein?
Universal stress protein MT2061.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
Protein: CSPL7_VITVI
Sequence: MSSVDTEKPAPPPLETEAPPPPPPPPPPPPPPPPPPAGYSALDVVLRILLLGSAVASVVVMVTSVQTKLIAVAGVPVLVSNKAKFQNSPAFIYFVAALSVVGLYSIITTLASFIFISKPSCSTKTILHLAIWDVLMLGLAASATGTAGGVAYVGLKGNSHVGWNKVCNTYDKFCRHVGGSIAVALFASILLVLLVWLSLFTLYSRIRK
What are the official names of this protein?
CASP-like protein 1D1, VvCASPL1D1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YORQ_SCHPO
Sequence: MFDSTKKSLHSMSDSANRFQNKITSKLPGEHGEDAMYDIRSVHGTGPRLSIKYVDVTKLPPPPKHASQLRAGGSSTGSTPRTASPAVGNQDYSKPSYSQPSYSQPSQPPKEPALPSRGTPSLPSRPGSRPSVLNQEQVPPPPVRPNVMSQMPPPPSYSSSGSYSQTYQSNANYTASSPLPTASANAPLPVPPPRRVSQNSSYASGSVPAATAASTASPVKKPPPPAPPKPRRLAARTSSNSSGVSSPTSVPPPVQRNTRPNL
What are the official names of this protein?
Uncharacterized protein P8B7.26.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at the cell tip and barrier septum.
Protein: PYRF_BACCZ
Sequence: MSQSLIVALDFPGKQDVEQFLRHFEGEELFVKVGMELFYKEGPAIITYLKEKGHKIFLDLKLHDIPNTVKSAMRSLASLDVDMVNVHAAGGSSMMKAAIEGLEEGKQEGKERPICIAVTQLTSTSEAMMKKEIGIEKTLEEAVAHYAKLTKESGLDGVVCSTLEVPKLREVCGSEFVTVTPGIRLASDDVNDQVRVATPKRARELGSSYIVVGRSITKAENPLEAYKTVKQQWEGVTV
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: BCHB_RHOPS
Sequence: MQLTVWTYEGPPHVGAMRVATGMEGLHYVLHAPQGDTYADLLFTMIERRNKRPPVTYTTFAARDLGKDTAELFMKAARDAYERFKPQAMIVGASCTGSLIQDDPGGLAKSLGFPIPVVAIDLPAYQRKENWGAAETLYQLVRALAGPKAPAPGAKRPERAPGVRPTCNLLGPTALGFRHRDDITEITGLLGKLGIDVNVVAPMGATPADIARLGDADFNVVMYPEIAGQAASWLHRIFHQPFTKTVPIGVSATRDFIKEVAQLAGVDATAVLEAASTRLPWYSHSVDSTYLTNKRVFIFGDATHAIAAARIASEELGFKVVGLGSYSREFGRELREAAKHYDVEPLITDDYLEVEAKVAELHPELVLGTQMERHIAKRLGVPCAVISAPVHVQDFPARYAPQMGFEGANVIFDTWVHPLMMGLEEHLLTMFKDDFEFKDGAMPSHLGTGHAAPVAEVIAESAPPAVAATAPEIVSVANAAASAAVWAPEAEKELQKIPFFVRGKARRNTERFANENGVATITVETLYDAKAHFAR
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: RL11_TROW8
Sequence: MADKKVVGVIKLQIQAGAANPAPPVGPALGQHGVNIMEFCKAYNAATESQKGNVIPVEISVYEDRSFTFVLKTPPVVELIKKAARISKGSPTPHNLKVAQITPEQVKSIAEAKMVDLNANDIDAASKIVRGTARSMGVTVA
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: HPPK_AQUAE
Sequence: MATVYLGLGSNVGDRISYILKAIEKLEEFLEIEKISTVYESKAWGFENQGNFLNFVLKAKTSLLPQELLLKIKKVEKEVGRKERFKWGPREIDIDILLYKDEVIRTKLLKVPHPFLEKRDFFVYPLLEIEPNVIHPIYRKPLKEFKPENTLKPFCCILKV
What is the function of this protein?
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
What are the official names of this protein?
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK.
What is the protein family that this protein belongs to?
Belongs to the HPPK family.
Protein: RL7_MARN8
Sequence: MALSKDDILNAIAEMSVMEVVELVEAMEEKFNVSAAAAVAAAPAAAAAGEAAEEKTEFDVVLTGAGEKKVNVIKAVRELTGLGLKEAKEMVDGAPSTVKEGASKDEAEEAKKKLEEAGASVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: GLNA_HALSA
Sequence: MTNGDSSSSALTDNERAVLDDIEAQGIDFLRLQFTDILGTVKNVSIPAHQAEKAFTEGIYFDGSSIEGFVRIQESDMRLDPDPETFAVLPWRSNGDGGSARLICDVVDREGNAFAGGPRQVLKNVLARADDMGYSVSIGPEPEFFLFEKDDDGNATTTAHDQGGYFDLAPKDLASDIRREIIFTLEAMGFEIEASHHEVARGQHEINFKYDDALTTADNIATFRAVVRAVAEQHDVHATFMPKPIGEINGSGMHSHISLFDEDGENVFADNDDEFNLSETAYQFMGGVLEHAPAFTAVTNPTVNSYKRLVPGYEAPVYIAWSGVNRSALIRVPDAAGVSARFEIRSPDPSCNPYLALAAVIAAGLDGIDTDADPGDAVREDIYEFDEDKRDAYGIDTLPGHLGDAVTALESDPVMQDALGEHVCEKFAEAKRHEYAEYKASVSEWETDRYLEKF
What is the function of this protein?
Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism.  It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.  Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA.  During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation.  Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity.  In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
What are the official names of this protein?
Glutamine synthetase, GS, Glutamate--ammonia ligase, Glutamine synthetase I alpha, GSI alpha.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_PAEAT
Sequence: MQPLVLPGFFIPSPTVSAVEIGPLTIRFYALCILAGIVIGAWLTARRFRARGGTTAQAMDIIMWAVPFGIVGGRLYHVITDNQLYFGPGKDPWGAFRIWEGGLGIWGAVAVGLAGAAIGARRTGVRLATFADAAAPGLLLAQAMGRWGNWFNNELYGEPTNLPWKLQIHNMNPATGQAVLTADGTPETLGYFQPTFLYESLWCLAAAALLVFLDRRYKLGAGSVFALYVVLYTAGRFIFELMRSDYANTILGLRVNTWVSALLFLAALAVFLILRSRPRSASTAQSACSIDGFDTRANGHDPEKHDETDGKGNRHHVP
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SI172_DICDI
Sequence: MTIFDSIALISKSSKSGLTSGNTTSKLNGITVGGNNVSSVNCGGCGGYTNNEPSLYGGNCGCN
What are the official names of this protein?
Protein sigN172, SrfA-induced gene N-like protein 172.
Protein: MUTS_ALKEH
Sequence: MAQSSPKASSRHTPMMRQFLRIKAEHPDILLFYRMGDFYELFYEDAERAAKLLDITLTTRGQSAGEPIPMAGVPVHAVESYLARLVRQGESVAICEQIGDPDNSKGPVERQVVRIVTPGTLTDEALLEERQSNILAALSCHQSRWGLASLELSSGRFSLTEPADEQALAADLERLNPAELLVDEALTLPTGLAVGPGLTRRPPWHFELDTATDLLTEQFGTRDLAGFGAQDHSAGLAAAGALLQYVRETQRSALPHIRRLQVEHGDQAIVIDAASRRNLELERNLSGGTEHTLASVLDSTVNAMGSRLLRRWLNRPLRDRTTLQARHQAVEILMAESLTEALRRQLRGISDVERILARVALGSARPRDLTGLRETLARLPDIQATLTGAGAPRLVDLAAQCGEHPQTLDHLRRALVDQPPVVIRDGGVIAEGYDATLDELRTLSENADNYLLELEQRERERTGISTLKVGYNRVHGYYIEVTRAQADAVPAEYVRRQTLKGVERYILPELKAFEDKVLSAREKALAREKVLYEQLLASLASDLAPLQDTAAALAELDTLAAFAERAQALDYSRPELRDGAGLRIEAGRHPVVEYSLDGPFVPNDLTLDDRRRMLIITGPNMGGKSTYMRQVALITLMAHIGSFVPARAASLGPVDRIFTRIGASDDLAGGRSTFMVEMTETANILHNATAQSLVLMDEIGRGTSTFDGLALAWATAERLARDQRAYTLFATHYFEMTALPEQCPGASNVHLDAVEHGERIVFLHAVKPGPASQSYGLQVAALAGVPGPVLEAAREKLRALEEESSRQRAEPDQLSLFAEPAPPPPLPSAAEQALSEVDPDELSPRQALDLLYRLKALTSGEEGADKKARGDAVDARSR
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: PANB_PYRAE
Sequence: MSARRRVTDFVKGKGPYVWVTAYDYPTAKIVDEAGVDGILVGDSLGMVVLGLPNTLGVTLADMIRHTQAVARARPRALVVADMPFMSYETGPRDALRNASKLIKAGADAVKLEGGAEYARIVEKLVKAGIPVMGHIGLNPQRVLALGGFKMVGRTEEQRRKLLDDAKALRDAGAFSLVIEFVPASVAKEITEAVDIPTICIGAGPHCDGQILVLHDIIGLTERPPSFAKRYANVADVIRSAVKQYVNEVKTGQFPSKEHFKE
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTH_ALKCK
Sequence: MVILTGRSLTLDDMEAILYKGVKVGLSQSCINEIEASRRAVEKIVQDGRTVYGINTGFGKFSDVQIAAADTEELQRNLILSHACGVGGYFSDEISQAMMVLRANALAKGFSGVRLEVVEMLLELINKDIYPCIPSQGSLGASGDLAPLSHLALVLIGEGEVRYRGECMSTASCFAKLGIQPLTLQAKEGLALINGTQAMTAVGVVAYLEAEKLAYQGEQIAAVTMEGLQGIIDAFDQAVHVARGYQEQIDVAARMRHLLQGSKLTTKQGEKRVQDAYSLRCIPQVHGAVWQALGYVKDKLLIEMNAATDNPLLFDEGEKVISGGNFHGEPIAFAMDFLCIAMAELGNIAERRVERLVNPQLNDLPPFLSPAPGLQSGAMIMQYVAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTIAARHALQIVENVRRICAIEAICALQAVEYRGIAAMAPATKTFFVEARRVVPTITADRVFAKDIEAMAQWLRNGGKAAAVLS
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VTC4_TRYCC
Sequence: MPFSKAWRSAVYPDFREQGAYINYKATKDILHRMKEDIANPSTPDELYNSLLLQKCRVYKWCEKKIKELLTVAEALMAASDYLTEEDTKTNLSLVLNTLGSGNMKCLPPNEARLLADSITHELLRFVECCNLNTDTIEHIIGRMYRYAVLGPTGKHWNNIMTEYDYHKLSIHEIFYLLSKVYDRVTATENMRIVKRSGIPAGTVGSQVFDRRSVKYWVHLQDLPFVIARIIPHLPHSTFKETYQTCKERNIPFTLGSPVSSVYWDNNEFLLYHRRLERLEGATLIRMRWYGDPLENDWNKLGPNDSVFMEIKVHHEAWSGERSNKRRFALKEKEVNSYVHGELDLNPALEKLRAKKASKKELHNFMDLSTEIVTKIDAYDLKPVIRTQCSRAAFQRGIDQSIRVSIDTDLRVCAEDFGLGHHWRYSGVDAPVSYFPYAVVEIKLQCAENERIAPWIEELMSCRYMESVPKFSKYAHGIASLYGHTPFIKMVPYWMHQLDIDIRASTKPEQNQWDPTVGLASGCWERTTDRAIFGVGHAQTQTVGASEAQFLPRTDYTRVYQKALHGIRGEGVATPATADNFQDAEAEGGCASGTAGSRKQQLQPRLPAHTLQYDVDRRHKAYTTFHLYPFAEYGVESLCFTPASGKNAAAEVLSGLIPWQTGKRIRVPQKYDPKTLLTSERYMLKWTEHATRLGLVGLGVIQFGNSMTLPGDVTQLSSFWRANFHIVLGIALVLVALMTLMYALMTFKARSRRVYARKKIRFDDSWGPTVLTVFLAFGICVIAMMHILGRYGPMLTGDDNF
What is the function of this protein?
Component of a polyphosphate synthase complex that utilizes ATP to synthesize and translocate polyphosphate to acidocalcisomes in epimastigotes, insect-stages of Trypanosoma brucei (PubMed:24386955).  Catalytic subunit of the vacuolar transporter chaperone (VTC) complex.  The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP.  VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation.  The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen.  PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase.  The VTC complex also plays a role in vacuolar membrane fusion (By similarity).  Essential for infection and parasite survival in the mammalian host (By similarity).
What are the official names of this protein?
Vacuolar transporter chaperone complex subunit 4, Polyphosphate kinase, SPX-dependent polyphosphate polymerase VTC subunit 4, Vacuolar membrane polyphosphate polymerase catalytic subunit, PolyP polymerase.
What is the protein family that this protein belongs to?
Belongs to the VTC4 family.
Protein: COX2_VULVU
Sequence: MAYPFQLGLQDATSPIMEELLHFHDHTLMIVFLISSLVLYIITLMLTTKLTHTSTMDAQEVETVWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTQELKPGELRLLEVDNRVVLPMEMTVRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMAMRPGLYYGQCSEICGSNHSFMPIVLEMVPLSYFETWSAVMV
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CML23_ARATH
Sequence: MSKNVSRNCLGSMEDIKKVFQRFDKNNDGKISIDELKDVIGALSPNASQEETKAMMKEFDLDGNGFIDLDEFVALFQISDQSSNNSAIRDLKEAFDLYDLDRNGRISANELHSVMKNLGEKCSIQDCQRMINKVDSDGDGCVDFEEFKKMMMINGSA
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Probable calcium-binding protein CML23, Calmodulin-like protein 23.