PharMolix/UniProtQA huggingface dataset:
Protein: R1A6_SOLDE
Sequence: MYFNNELSDLKDHLLRKLQYYTYSDVVRDRINFILWEFKFLDCFLYLKSFPFASECGMLHVSQKMIEIWKSQWNKLIYICMYDEEGSPWDAVVYWKELISQTKQEFRAQYSFPKSPLAANEVIDDDDDDNTHSPEFVMEVIGFFVGNINVLVKINDPCSCFFVPGLKEQIEQILKELKLLRFLVCFVSNKCIVPQYRCTTFYTRALIEASYIAMVAWLYLPIYGNGNQDLAPSEVSRLLSDFMEMKIKSIEPGISRNSIYIDVLQALKSTIPQAQKKHVEIPTHSLTVGLSDQMANLQEMLCLLRDNLIHLPILDLEFHLQDMDSVIVDAGLLIYSLYDIKGQMEDTSLDVINWALGFDLPRNIEPIKVMAYLVMQKAFHCNLPRIHGLGYVDFLLKNLNDFQDCYSDSLAFLKNQLQVIQTEFESLQPFLKVVAEEPHNKLKTLNEDCATQIIRKAYEVEYVVDACINKEALHWCLERWLLDIIEEITCIKAKIQEKNTVEDTMKTVIARTSSKLARTPRMKEEIVGFEDVIENLRKKLLSRTKGQDVISIHGMPGLGKTTLANRLYSDRSVVSQFDFCAQCCVSQVYSCKDLLLSLLRDAIGEESERRELPDNELADMLRKTLLPRRYLILVDDVWDNSAWDDLRGCFPDVNNRSRIILTTRHHEVAKYASVRSDPLHLRMFDEVESWKLLEKKVFGEQSCPPLLKNIGLRIAKMCGQLPLSIVLVAGILSEMEKDVECWEQVANNLGSHIHNDSRAIVDQSYHVLPCHLKSCFLYFGAFLEDRVIDISRLIRLWISEAFIKSSEGRSLEDIAEGYLENLIGRNLVMVTQRAISDGKVKACRLHDVLLDFCKERAAEENFLLWINRDQITKPSSCVYSHKQHAHLAFTEMHNLVEWSASCSFVGSVVLSNKYEPYFHDLSSLHDFSISRILPNFKFLKVLDLEHRVFIDFIPTELPYLRYFSALIDQNSIPSSISNLWNLETLILNRRSADSHNRVLLPSTVWDMVKLRHLHIPNFSPENKKALLKNSPNLDDLETLSYPYFARVKDAELMLRKTPNLRKLTCKVKCLEYLHQYHALNFPIRLEILKLYRSNAFKAIPFCISAPNLKYLKLSGFYLDSQYLSKTADHLKNLEVLKLYYVEFGDHREWKVSNGMFPQLKILKLEDVSLMKWIVADDAFPNLEQLVLRGCQDLMEIPSCFMDILSLQYIEVEDCNESVVKSAMNIQETQVEDYQNTNFKLVLIEKWPKFYKLFSQLSLPRGLVLHLGIESVSSDEKEKKLTVTGDVDADEVQLVVEKLRKCGMPGL
What is the function of this protein?
Confers resistance to late blight (Phytophthora infestans) races carrying the avirulence gene Avr1.  Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein.  That triggers a defense system including the hypersensitive response, which restricts the pathogen growth.
What are the official names of this protein?
Putative late blight resistance protein homolog R1A-6.
What is the protein family that this protein belongs to?
Belongs to the disease resistance NB-LRR family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: ATP6_RHOE4
Sequence: MMAADRLRERTLSVTTLAADEFHAPSLDDFFPPSVLIHAGPFELDRLMLIRLLMSVLVAAFFVIAMRSPRLVPRGMQNAAELALDFVRINIAEEILGKEQGKRFLPVITTIFFIVVASNMASIIPFLNISPNARIGMPLVLAALAYIVFNYVGIKKYGFFKYVKSSIVVPGVPLPLHFLLVPIEFISTFILRPFTLMVRLMANMLAGHILLVLFFSATNYFFFVSGGFQAIFGVPSIIAGIAFTFFELLVIFLQAYVFALLTAVYIELALHADEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VMA21_XENTR
Sequence: MERYDKASLNAANVPLPEFSQNEGSLVATLKTLLFFTVLMIMLPIGLYFSSKVYVFEGTYGMSNRDSYFYAAIVAVVAVHVVLAMFVYVAWNEGSRQWREGKQD
What is the function of this protein?
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
What are the official names of this protein?
Vacuolar ATPase assembly integral membrane protein vma21.
What is the protein family that this protein belongs to?
Belongs to the VMA21 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.
Protein: METK_STRAW
Sequence: MSRRLFTSESVTEGHPDKIADQISDTILDALLREDPTSRVAVETLITTGLVHVAGEVTTKAYAPIAQLVRDKILEIGYDSSKKGFDGASCGVSVSIGSQSPDIAQGVDTAYENRVEGDEDELDRQGAGDQGLMFGYATDETPTLMPLPIHLAHRLSHRLSEVRKNGTIPYLRPDGKTQVTIEYDGDKAVRLDTVVVSSQHASDIDLDSLLAPDIREFVVEPELKALLDDGIKLETEGYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLASRCEVQVAYAIGKAEPVGLFVETFGTAKVEADKIEQAIATVFDLRPAAIIRDLDLLRPIYSQTAAYGHFGRELPDFTWERTDRVDALRTAVGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XAMOA_XANP2
Sequence: MALLNRDDWYDIARDVDWTLSYVDRAVAFPEEWKGEKDICGTAWDDWDEPFRVSFREYVMVQRDKEASVGAIREAMVRAKAYEKLDDGHKATSHLHMGTITMVEHMAVTMQSRFVRFAPSARWRSLGAFGMLDETRHTQLDLRFSHDLLNDSPSFDWSQRAFHTDEWAVLATRNLFDDIMLNADCVEAALATSLTLEHGFTNIQFVALASDAMEAGDVNFSNLLSSIQTDEARHAQLGFPTLDVMMKHDPKRAQQILDVAFWRSYRIFQAVTGVSMDYYTPVAKRQMSFKEFMLEWIVKHHERILRDYGLQKPWYWDTFEKTLDHGHHALHIGTWFWRPTLFWDPNGGVSREERRWLNQKYPNWEESWGVLWDEIISNINAGNIEKTLPETLPMLCNVTNLPIGSHWDRFHLKPEQLVYKGRLYTFDSDVSKWIFELDPERYAGHTNVVDRFIGGQIQPMTIEGVLNWMGLTPEVMGKDVFNYRWAGDYAENRIAAE
What is the function of this protein?
Component of the alkene monooxygenase multicomponent enzyme system which catalyzes the O2- and NADH-dependent epoxidation of short chain (C2 to C6) alkenes to their corresponding epoxides (PubMed:10103255, PubMed:1444418, PubMed:9312093).  Also able to catalyze the oxidation of a number of chlorinated alkenes, including trichloroethylene, cis- and trans-1,2-dichloroethylene, vinyl chloride, 1-chloropropylene, 1,3-dichloropropylene and 2,3-dichloropropylene (PubMed:1444418).
What are the official names of this protein?
Alkene monooxygenase system, oxygenase component subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the TmoA/XamoA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX4A_PARAW
Sequence: MKLGIFFSVFFLAMIHSCLSETNEDKNLESYFREDDLKALSFGEYARAMMAESRKDNCIPKHHECTSRPKDCCKQNLMQFKCSCMTIIDKNNKETERCKCDNSIFQKVAKTSVNIGKAVVTK
What is the function of this protein?
Potent antibacterial peptide with anti-inflammatory properties.  Inhibits both Gram-negative and Gram-positive bacteria by disrupting both the outer membrane and the cytosolic membrane of bacteria.  Also downregulates the expression of pro-inflammatory mediators (cyclooxygenase-2 (PTGS2/COX2), nitric oxide-induced synthase (NOS2), IL-1 beta (IL1B), TNF-alpha (TNF)) and upregulates the level of anti-inflammatory cytokine (IL10) by inactivating mitogen-activated protein kinase signaling in a lipopolysaccharide-stimulated murine macrophage cell line.
What are the official names of this protein?
Lycotoxin-Pa4a, LCTX-Pa4a.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: FDL35_ARATH
Sequence: MEECDYINELPDSLLTQILLDLRTKDSVKTSVSSKRWRNLWLNVPGLDLFSLQFTNPHHEEGLIKFMDRFMESNCRSRLQKFMIRYFECNGYRDRFMELIGTVVDCGIQHLYVYMHTCNRVDFIRQNIYKSKTLVSLKLYNVELKNPDFVVSLPCLKILKLMKICYGEDGPLVVEKLISGCPVLEDLELIKPFDILTQDVILFLRVSSQTLKSLRLYFATNGSVEIDAPRLKYMTFYESRFDRIMVKNMSSLFSIEIRAKSSFEYGGLLKAEDPRKRAIICDFLTVISSVRHMIISGSILEELHSYSKLGWIPQFRNLYHLQASFFGTSLQLLPTFLESCPNLKNLIMDYGAFKEENIDFHEVPQCLISTLEYVHINKLMMMEQSGIKLVNYFIENSAVLKKLTLRFSFFSSIESESYKKLLTSTKLSPTCQVIFV
What are the official names of this protein?
Putative F-box/FBD/LRR-repeat protein At5g44960.
Protein: RL15E_THEKO
Sequence: MGMYKYIREAWKSPKKSYVGELLKKRMIQWRRDPVVKRIERPTRLDRARSLGYQAKQGYVVVRVRVRRGGRKRPRWKGGRKPSKMGMVKYSPKKSLQWIAEEKAARKFPNLEVLNSYWVGEDGMYKWFEVIMVDPHHPVIKSDPKIAWIAGKAHKGRVFRGLTSAGKRSRGLLNKGKGAEKVRPSIRAHQGKGK
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: GPDA_PSEU2
Sequence: MTTQQPVAVLGGGSFGTAIANLLAENGHQVRQWMRDPEQAEAIRVNRENPRYLKGIRIRPEVEPVTDLTAVLDASELIFVALPSSALRSVLSPHVARLNGKMLVSLTKGIEAQSFKLMSQILEEIVPQARIGVLSGPNLAREIAEHALTATVVASEDEALCQEVQAALHGRTFRVYASNDRFGVELGGALKNVYAIIAGMAVALDMGENTKSMLITRALAEMTRFAVSQGANPMTFLGLAGVGDLIVTCSSPKSRNYQVGFALGQGLTLDEAVTRLGEVAEGVNTLKVLKVKAQEVQVYMPLVAGLHAILFEGRTLSQVIEALMRAEPKTDVDFISITGFN
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDLI7_CHICK
Sequence: MESYKVMLNGPAPWGFRLQGGKDFSMPLSISRLTPGGKAAQAGVGVGDWVLYIDGESTGTMTHIEAQNRIRACGDRLCLTLSRAQNHLGKPQKDSLPCSEPPKYNFAPSTALNKTARPFGASSPPNPRPGLVTKPVTYVPLAPACTPQHNGQVSVPDPSPGAAMKTEPGLAPRTPAATPGPTSRPPWAVDPSFAERYAPDKTSTVLSKHSQPATPTPMQNRSSIVQAAQQAPESPGRTPLCYKCNKIIRGRYLVALGHYYHPEEFTCCQCRKVLDEGGFFEEKGSIFCPKCYDTRYAPSCAKCKKKITGEVMHALKMTWHVQCFTCAACKTPIRNRAFYMEEGQPYCERDYEKMFGTKCRGCDFKIDAGDRFLEALGFSWHDTCFVCAICQTNLEGKTFYSKKDKPLCKSHAFSHV
What is the function of this protein?
May function as a scaffold on which the coordinated assembly of proteins can occur.  May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues.  May be involved in bone formation (By similarity).
What are the official names of this protein?
PDZ and LIM domain protein 7, LIM mineralization protein, LMP.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TPM2 near the Z line in muscle (By similarity). Colocalizes with TBX4 and TBX5 to actin filaments.
Protein: ERPA_SODGM
Sequence: MSETATLPLRFTDSAASKVKNLIADEENPNLKLRVYITGGGCSGFQYGFTFDDKVNEDDFTIEKQGVALVVDPMSLQYLVGGSVDYSEGLEGSRFIVTNPNAKTTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: DYHC_ONCMY
Sequence: PSMLFSTVPSTLFSTVPSTLFSTVPSTLFSTVSSVIQYSIHVIQYSTLHVIQYSTLHVIQYSTLHVIQYSTLNVIQYSTLHVIQYSTLHVIQYSILHVIQYSIHVIQYSIHVTQYSILHVIQYSIHVIQYSIHVIQYSTHVIQYSIHVIQYSIHVIQYSILHVIQYSIHVIQYSIHVIQYSTHVIQYSIHVIQYSILHVIQYSILHVIQYSILHVIQYSIHVIQYSIHVIQYSIHVIQYSIHVIQYSILHVIQYSIHVIQYSIHVIQYSIHVIQYSILHVIQYSILHVIQYSIHVIQYSIHVIQYSIHVIQYSILHVIQYSIHVIQYSIHVIQYSIHVIQYSIHVIQYSIHVIQYSILHVIQYSIHVIQYSIHVIQYSIHVIQYSIHVIQYSILHVIQYSILHVIQYSIHVIQYSILHVIQYSIHVIQYSIHVIQYSILHVIQYSIHVIQYSILHVIQYSIHVIQYSIHVIQYSILHVIQYSIHVIQYSILHVIQYSIHVIQYSILHVMILACSM
What is the function of this protein?
Force generating protein of eukaryotic cilia and flagella.  Produces force towards the minus ends of microtubules.  Dynein has ATPase activity.
What are the official names of this protein?
Dynein heavy chain, DYHC.
What is the protein family that this protein belongs to?
Belongs to the dynein heavy chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: RS16_FRIAG
Sequence: MATPATESVQCFGRKKTAVAVTHCKRGRGLIKVNGSPIELVKPEILRYKAFEPILLLGRHRFVGVDMRIRVRGGGKTSQIYAIRQSIAKALVAYYQKYVDEQAKKEVKDILMRYDRTLLVADPRRCEPKKFGGRGARSRFQKSYR
What are the official names of this protein?
40S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN151_HUMAN
Sequence: MGGGYDLNLFASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCILRWLARQKTCPCCRKEVKRKKVVHMNKLRKTIGRLEVKCKNADAGCIVTCPLAHRKGHQDSCPFELTACPNEGCTSQVPRGTLAEHRQHCQQGSQQRCPLGCGATLDPAERARHNCYRELHNAWSVRQERRRPLLLSLLRRVRWLDQATSVVRRELAELSNFLEEDTALLEGAPQEEAEAAPEGNVGAEVVGEPRANIPCK
What is the function of this protein?
May be involved in acrosome formation of spermatids.
What are the official names of this protein?
RING finger protein 151.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NRDR_PARXL
Sequence: MHCPFCRHADTQVVDSRVSEDGATIRRRRRCPACDKRFTTYERVELALPSVVKKDGSRTEFDRRKIVASMQLALRKRPVAADAIEAAVARIEYQLLGSGEREVRSERLGELVMNELRALDTIAYVRFASVYRRFEDVSEFEDVIEEFRRASSPPKPSRKR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: UBIG_CHRVO
Sequence: MSNVDELEIDKFSQLAHKWWDKDSEFKPLHEINPLRLDFIDRHASIAGKKVLDVGCGGGILAESMALRGAQVTGIDLAKKSLKVAQLHSLESGVPIDYRCVAVEDLAAEMPGAFDAVTCMEMLEHVPDPESVVRACSTLVKPGGWVFFSTLNRNAKAYLLAVVGAEYVLNMLPRGTHEYARFLKPSELGRMARHAGLGLQTLSGMGYNPVTRIYSLNDDTAVNYLMATRRAD
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: ESCA_TRICA
Sequence: IRTHTLPCKCTICPKAFSRPWLLQGHIRTHTGEKPFSCTYCNRAFA
What are the official names of this protein?
Escargot/snail protein homolog.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SCAF_BPB03
Sequence: MPMERDSHEEILNKLNDPELEHSERTELLQQLRADYGSVLSEFSELTSATEKLRAENSDLIVSNSKLFRQVGITKEKEEEIKQEELSETITIEDLEKQAQL
What is the function of this protein?
Scaffolding protein involved in the icosahedric procapsid assembly.  Coassembles with the capsid proteins to form the procapsid.  The scaffolding protein is found within the capsid as a serie of concentric shells.  During DNA packaging, the scaffolding protein molecules are released from the procapsid.
What are the official names of this protein?
Capsid assembly scaffolding protein, Gene product 7, gp7, Head morphogenesis protein, Protein p7, Scaffold protein.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus scaffolding protein family.
What are the subcellular locations of this protein?
Note=Present in about 147 copies in the prohead but not present in mature virions.
Protein: NPF2_LEPDE
Sequence: APSLRLRF
What is the function of this protein?
Neuropeptide.  May be involved in the regulation of adult diapause.
What are the official names of this protein?
Neuropeptide NPF-2, Led-NPF-2, Short neuropeptide F II.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: AZOR3_BACHK
Sequence: MTKVLFVKANNRPAEQAVSVKLYEAFLASYKEAHPNDTVVELDLYKEELPYVGVDMINGTFKAGKGFDLTEEEAKAVAVADKYLNQFLEADKVVFGFPLWNLTIPAVLHTYIDYLNRAGKTFKYTPEGPVGLIGDKKIALLNARGGVYSEGPAAEVEMAVKYVASMMGFFGATNMETVVIEGHNQFPDKAEEIITAGLEEAAKVANKF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 3, Azo-dye reductase 3, FMN-dependent NADH-azo compound oxidoreductase 3, FMN-dependent NADH-azoreductase 3.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: PLDA2_BRAOC
Sequence: MAQHLLHGTLHATIYEVDALHTGGLRSAGFLGKIISNVEETIGFGKGETQLYATIDLQKARVGRTRKITDEPKNPKWYESFHIYCAHMASDIIFTVKDDNPIGATLIGRAYVPVDEVINGEEVEKWVEILDDDRNPIHGESKIHVKLQYFAVEADRNWNMGVKSAKFPGVPYTFFSQRQGCKVSLYQGAHVPDNFVPKIPLAGGKNYEPHRCWEDIFDAITNAKHLIYITGWSVYTEITLVRDSRRPKPGGDMTLGELLKKKATEGVRVLLLVWDDRTSVDVLKKDGLMATHDEDTENYFNGSEVHCVLCPRNPDDGGSIVQNLQVSAMFTHHQKIVVVDSEVPSQGGGSEMRRIMSFVGGIDLCDGRYDTPFHSLFRTLDTVHHDDFHQPNFTGASITKGGPREPWQDIHSRLEGPIAWDVLYNFEQRWSKQGGKDILVKLRELSDIIITPSPVMFQEDHDVWNVQLFRSIDGGAAAGFPDSPEVAAEAGLVSGKDNVIDRSIQDAYIHAIRRAKDFIYIENQYFLGSSFAWAADGITPEDINALHLIPKELSLKIVDKIEKGEKFRVYVVVPMWPEGIPESASVQAILDWQRRTLEMMYKDVTQALRAQGLEEDPRNYLTFFCLGNREVKKEGEYEPAERPDPDTDYMRAQEARRFMIYVHSKMMIVDDEYIIVGSANINQRSMDGARDSEIAMGGYQPHHLSHRQPARGQVHGFRMSLWYEHLGMLDETFLDPSSLECIEKVNRIADKYWDFYSSESLEHDLPGHLLRYPISVDNEGNITELPGFEFFPDSKARILGNKVDYLPPILTT
What is the function of this protein?
Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond.  Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence.
What are the official names of this protein?
Phospholipase D alpha 2, PLD 2, Choline phosphatase 2, Phosphatidylcholine-hydrolyzing phospholipase D 2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. C2-PLD subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: DX39B_CHICK
Sequence: MAENDVDNELLDYEEDEVENAAGGDGSEAPPKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPSVKVAVFFGGLAVKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDMRRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYVKLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR
What is the function of this protein?
Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint.  Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity.  Even with the stimulation of RNA, the ATPase activity is weak.  Can only hydrolyze ATP but not other NTPs.  The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA.  However, ssRNA stimulates the ATPase activity much more strongly than dsRNA.  Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro.  The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly (By similarity).
What are the official names of this protein?
Spliceosome RNA helicase DDX39B, 56 kDa U2AF65-associated protein, DEAD box protein UAP56.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: IL12A_HORSE
Sequence: MCPPRGLLLVAILVLLNHLDHLSLARNLPTATPGPGMFQCLNHSQNLLRTVSNTLQKARQTLEFYSCTSEEIDHEDITKDKSSTVAACLPLELAPNESCLASREISFITNGSCLTPGKASSMMTLCLSSIYEDLKMYQVEFKAMNAKLLIDPQRQIFLDENMLTAIDKLMQALNFNSETVPQKPSLEGLDFYKTKVKLCILLHAFRIRAVTINRMMGYLNAS
What is the function of this protein?
Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine.  IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity.  Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits.  Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2.  In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity).  As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity).  Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers.  Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
What are the official names of this protein?
Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1531_BACF6
Sequence: MDWIVHQLRVHPELAIFLTLFVGFWIGKIKIGKFSLGVVTSVLLVGVLVGQLDITVDGPIKSVFFLLFLFAIGYKVGPQFFRGLKKDGLPQMGFAAIMCVFCLIIPWILAKIMGYNVGEAAGLLAGSQTISAVIGVAGDTINELNISPETKEAYNNIIPVSYAVTYIFGTAGSAWVLGSLGPRLLGGLDKVKAACKELEAKMGNNEADQPGFMAAARPVTFRAYKIANEWFGDGKRVSDLESYFQENDKRLFVERVRQAGVIVKEVSPTFVLKKGDEVVLSGRREYVIGEEDWIGPEVLDPQLLDFPAEVLPVMVTRKTVAGEKVSTIRALKFMHGVSIRRIKRAGIDIPVLAQTVVDAGDMVELVGTKHEVDAAAKQLGYADRPTNQTDMIFVGLGILIGGLIGALSIHMGGVPISLSTSGGALIGGLFFGWLRSKHPTFGRIPEPALWILDNVGLNMFIAVVGIAAGPSFVQGFKEVGLSLFIVGALATSIPLIAGVLMAKYIFKFHPALVLGCTAGARTTTAALGAIQEAVESETPALGYTVTYAVGNTLLIIWGVVIVLLM
What are the official names of this protein?
Uncharacterized transporter BF638R_1531.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BDG2_ARATH
Sequence: MGIARWLNRTVGFFVFALLDIADFLLCYTYKTLDYFLESERKPCYCSSPPEAKAKTEKIIVSERGGYSKVVSLTRSKIHFDEISDTLYSRGPSLLTRLSKLVRSVKCFNYKGLIMRGNVVESCDHHESKKKISKGKKRLMTLNSTVIEKSSTAPRWSDCHCSFCTSWLTSTNRDSLFVKVQQPKDNKKARDNVVFIHGFVSSSAFWTETLFPNFSDSAKSNYRFIAVDLLGYGRSPKPNDSLYTLREHLEMIEKSVISKFKLKTFHIVAHSLGCILALALAVKHPGAIKSLTLLAPPYYKVPKGVQPAQYVMREVARKEVWPPMQFGASVLSWYEHLGRTIGLVLIKNHQLIEFVTRLLTLNRMRTYLIEGFLCHTHNGSFHTLHNIIFGSGAKLDSYLDHVRDHVDCDVAIFHGGKDELIPVECSYSVKSKVPRATVHVIPDKDHITIVVGRQKDFARELELIWQRTKST
What is the function of this protein?
Involved in cuticle development and morphogenesis.
What are the official names of this protein?
Probable lysophospholipase BODYGUARD 2, AtBDG2.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Secreted, cell wall.
Protein: PETR_RHOCB
Sequence: MMSASPPHLLIVDDDERIRGLLQKFLIRNGFLVTAGRDAAHARRLLSGLEFNLIVLDVMMPGEDGLSLTRDLRTKMATPILLLTARGETRERIEGLEAGADDYLPKPFEPKELLLRINAILRRVPEAVTAGPKYLSLGPLRYDLDRGELSQGDQPVRLTATEAALMRIFAAHAGEVIGRTELIEELGRDRSASAEEAAGDRAVDVQITRLRRKIEPDPREPRYLQTVRGLGYMLAPD
What is the function of this protein?
Necessary for photosynthetic and respiratory growth.  Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase.
What are the official names of this protein?
Protein PetR.
Protein: SYGB_YERE8
Sequence: MTQQTFLVEIGTEELPPKALRSLAESFAANFTAELNNANLPYGEVIWYAAPRRLALKVTNLSATQADREVEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLVTDKGEWLLYRAHVKGQSAQLLLAGMVNTALSKLPIPKLMRWGDKDTQFVRPVHTVTMLLGSEVIPGTVLGIDSDRIIRGHRFMGEPEFTLDNADQYPQVLQERGKVIADYELRKAIIKRDAELAAQKIGGVADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPAEALVYTMKGDQKYFPVYDTAGNLLPNFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFKTDRKKRLEDNLPRLETVLFQQQLGTLRDKTDRIQALAGWVAAQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLPLDLQTLTEEAVRLYGSKLTNTKVVDEVIEFMLGRFRAWYQDEGHSVDTIQAVLARRPTRPADFDARVKAVTYFRTLDAAAALAAANKRVSNILAKSTDKLNDHVRASVLKEPAELKLATHLVVLRDKLEPVFAAGQYQEALVELAALRETVDEFFESVMVMDEDDAVRVNRLTLLSKLRELFLQVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.