PharMolix/UniProtQA huggingface dataset:
Protein: TDH_HUMAN
Sequence: MLFIRMLRRAGQSPACGCWTPVLPVRFLGISPRQIPADANFHSASFSDTDHPRVLITGALGQLGVGLANLLRKRFGKDSVILSDIRKPPDHVFHSGPFIYSDILDYKNLREIVVNNRITWLFHYSALLSAFGEANVSLARAVNITGLHNILDVAAEHNLQLFVPSTIGAFGPTSPRNPTPDLCIQRPRTIYGVSKVHAELMGETMQSRFSMMPQSMANSSATWKPARDCP
What are the official names of this protein?
Inactive L-threonine 3-dehydrogenase, mitochondrial, Short chain dehydrogenase/reductase family 14E member 1 pseudogene.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PDXT_HAEI8
Sequence: MKIGILALQGAFAEHARMLEKLGIESVELRNLKNFQQHYSDLSGLILPGGESTAIGKLLRELYMLEPIKQAISSGFPVFGTCAGLILLAKEITSQKESHFGTMDIVVERNAYGRQLGSFYTEADCKGVGKIPMTFIRGPIISSVGKKVNILATVNNKIVAAQEKNMLVTSFHPELTNNLSLHKYFIDICKVA
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: RL23B_YEAST
Sequence: MSGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSRLNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIANPKGEMKGSAITGPVGKECADLWPRVASNSGVVV
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L23-B, L17a, Large ribosomal subunit protein uL14-B, YL32.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_PSET1
Sequence: MSKDIHDSRILILDFGSQYTQLIARRVREIGVYCELWAWDVTEEQIREFNPQGIILSGGPESTTLENSPRAPEYVFNAGVPVLGICYGMQTMAAQLGGSVHSSDKKEFGYAQVEKVGNCALFDAIEDHITDGGNGVLDVWMSHGDKVMDIPQSFKTTAKTSTCPHAAMSNEEKRFYGVQFHPEVTHTHQGQRLLERFAIDICGCEKLWTAAKIIDNAIERIKETVGDDEVILGLSGGVDSSVVAMLIHRAIGEKLTCVFVDNGLLRLNEGQQVMDMFGNKFGLNIVKVEAEEQFLNDLAGKSDPEDKRKAIGHTFINVFDEQAKKLKNAKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPADMKMGLVEPLRELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEIKKEYCDLLRRADAIFIEELHKAELYHKVSQAFTVFLPVKSVGVMGDARKYDWVVSLRCVETIDFMTARWSHLPYEFLGVVSNRIINEIDGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: AROA_CAMJE
Sequence: MKIYKLQTPVNAILENIAADKSISHRFAIFSLLTQEENKAQNYLLAQDTLNTLEIIKNLGAKIEQKDSCVKIIPPKEILSPNCILDCGNSGTAMRLMIGFLAGISGFFVLSGDKYLNNRPMRRISKPLTQIGARIYGRNEANLAPLCIEGQKLKAFNFKSEISSAQVKTAMILSAFRADNVCTFSEISLSRNHSENMLKAMKAPIRVSNDGLSLEINPLKKPLKAQNIIIPNDPSSAFYFVLAAIILPKSQIILKNILLNPTRIEAYKILQKMGAKLEMTITQNDFETIGEIRVESSKLNGIEVKDNIAWLIDEAPALAIAFALAKGKSSLINAKELRVKESDRIAVMVENLKLCGVEARELDDGFEIEGGCELKSSKIKSYGDHRIAMSFAILGLLCGIEIDDSDCIKTSFPNFIEILSNLGARIDY
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP4_ROTEH
Sequence: MDKLTDLNYTLNVITLLNSTLHTILEDPGMAYFPYIASVLTVLFTLHKASIPTMKIALRTSKCSYKVIKYCIVTIFNTLLKLAGYKEQITTKDEIEKQMDRVVKEMRRHLEMIDKLTTREIEQVELLKRIYDKLMIRATDEIDMTKEINQKNVKTLEEWENGKNPYESKEVTAAM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: GATC_DESAH
Sequence: MKISKQDVEHLAHLARLAVDGSQVESLTAQVSNILDYMDVLKEVDVDGVPLASGAALGTNVFRQDQVKPSPGPCVTLANAPERDDDFYTVPRIVG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: AMT25_MEDTR
Sequence: MSGVPFPSNLLPSPSSPEWLSKADNAWQLMAATLVGMQSVPGLIILYGGAVKKKWAVNSAFMSLYAFACVFFCWVFWAYRMSFGDTLFPFWGKPALALDEKYLFKQAFLGAFPNATMIYFQCVFAAITLILIAGAVLGRMNFYAWMMFVPLWLTFSYTFTAFSIWSTNGFLAKMGIIDYSGGYVIHLSSGVAGFTAAYWVGPRLNKDRERFPPNNLLLMLAGAGLLWMGWTGFNGGDPYSVGLDASLAVLNTHACTATSLLTWVFLDVIFFRKPSVIGAVQGMITGLVCITPAAGVVQGWAALIMGLFSGSIPWFTMMVIHKRSKLLQKVDDTMAVLHTHAIAGSLGGILTGLFAEPKLNSLFYGVYNKYVGLFYGIQMNMASTGRRQIGIQLLGILFVIFVNVVSTSLICLFIRLFVPLRMSEEDMEIGDEAAHGEEAYAIWGQGDKHENSNSKYGSSLYEDVEVAATTKNKRGSQIEMM
What is the function of this protein?
Involved in ammonium transport (By similarity).  May be involved in arbuscular mycorrhizal (AM) symbiosis with AM fungi (By similarity).
What are the official names of this protein?
Ammonium transporter 2 member 5, Ammonium transporter 2;5, MtAMT2;5.
What is the protein family that this protein belongs to?
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FAP3_ARATH
Sequence: MDGILAAVPSAVCVSLRISCRNLDNAESIYHFPGKSLNRVSVLQTGNYVSRKGNSLLKNRHCGEISRVIVKSAASSVGNAEDYAEETATSVKFKRSVTLPGCSSPLSLLGTGFREKKFAIIGVKVYAAGYYVNESILSGLSAWTGRSADEIQRDSSLFVSIFQAQAEKSLQIVLVRDVDGKTFWDALDEAISPRIKSPSSEDTTALSTFRGIFQNRPLNKGSVILLTWINTSNMLVSVSSGGLPTNVDATIESGNVTSALFDVFFGDSPVSPTLKSSVANQLAMTLV
What is the function of this protein?
Fatty-acid-binding protein.  Interacts with most fatty acids tested and has maximal relative affinity for C16:0.
What are the official names of this protein?
Fatty-acid-binding protein 3, chloroplastic, AtFAP3, Chalcone-flavanone isomerase family protein 3.
What is the protein family that this protein belongs to?
Belongs to the chalcone isomerase family.
Protein: RL18_AYWBP
Sequence: MITKQSSNALRKKRHLRLRKIVSGTSQRPRLNVFRSNKFLYVQIIDDTKQTTLCSANSKEANVWGSNIKAAEAVGALIAKKALSQGIKNVVFDRSGYFYHGKIKALADACRKSGLHF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: YEGS_XANAC
Sequence: MAPSHWRLILNGKSTDNLDLREAVGTLRKRGIQLDVRVTWEDGDAERYVGEAVADGVHTVVAAGGDGTLSEVAAALAHHEGDAATLPSLGLVPLGTANDFATAATLPIAPLEALTLIAERVAQPVDLLRIDADHGPHWCANVASGGFGTQVTVETDEGLKKMLGGLAYLITGMSRLGRIDPISARFSGPEFSWEGEFIALGLGNGRQAGGGQALCPEALIDDGLLDVTIVPDLDGEVAATLGTLVTGGKQAALERVAVRARVPWLDIVSQQPLTLNLDGEPETSRHFRIECVPARLRMHLPGECPLLGG
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS-like.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_WOLPM
Sequence: MNNEDISDKKLTLQGLSKLKLDLNLNSSASPSTGATVVKKRRKKSHDAEEHNLFDESKLCSLTEKEQIFRINAVQNAALLKERNQREEKEKTAKEDSNKEIDEKNEADALSKEINKQVLSNTHLVEPKEDSIDHEDNDKKSFKVNKDIYSKHSKLVIAQAIDEKTEQPPVFKQRFGIRGRKSKFTKGKNISREVIIPDKITIRELSIRMAEDSKSVLKMFKEEVGESYRVDDLVDPDIACEIVEKFNHTAKRVSDTNREKDLFFIEGRESLPKKPKPPIVTFMGHVDHGKTSLLDAFRESNVAERESGGITQHIGAYQITTKDKQKITFIDTPGHEAFTAMRARGANITNIVVIVVAADDGIMKQTVEAINHAKAANVSIIVAINKIDKSEPGDVEKIINSLPQYDLIPEGLGGDVMIMPVSAKKKTNLDKLEEAILLIAELMKLEAIEDCRALGWVIESKIDKAKGISATLIVEEGTLKVGDILVVGTTYSKVRSMVNHLGQREKAALPSAPIEITGLNGVPNAGDKFVVVNSEKQAREIVEYRLELIKKKKEDLGDNNLDIFSRNNSETEELSVVLKCDVTGSIEAISSSIDKLGKDQVKLNILHKAVGGITDSDVLLAEASSAVILAFNVKVDSKIRDLAKQKGIEIHTYNIIYELIDDMRMYLTKMLKPVTREVRVGFASVRQIFNVSKAGNIIGCYVSDGVIRKDSLIKVMRGGKLVHEGKLKALRRFKDDIKEVGVNFECGVSLEGNVDIKVGDILEAYQLVQEERVL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ST1A1_RAT
Sequence: MEFSRPPLVHVKGIPLIKYFAETIGPLQNFTAWPDDLLISTYPKSGTTWMSEILDMIYQGGKLEKCGRAPIYARVPFLEFKCPGVPSGLETLEETPAPRLLKTHLPLSLLPQSLLDQKVKVIYIARNAKDVVVSYYNFYNMAKLHPDPGTWDSFLENFMDGEVSYGSWYQHVKEWWELRHTHPVLYLFYEDIKENPKREIKKILEFLGRSLPEETVDSIVHHTSFKKMKENCMTNYTTIPTEIMDHNVSPFMRKGTTGDWKNTFTVAQNERFDAHYAKTMTDCDFKFRCEL
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe.  Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites.  Displays broad substrate specificity for small phenolic compounds (PubMed:8447833, PubMed:7889867, PubMed:1513323).  Plays an important roles in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (By similarity).  Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (PubMed:1513323).  Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (By similarity).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system.
What are the official names of this protein?
Sulfotransferase 1A1, ST1A1, Aryl sulfotransferase, Aryl sulfotransferase IV, ASTIV, Minoxidil sulfotransferase, Mx-ST, PST-1, Phenol sulfotransferase, Sulfokinase, Tyrosine-ester sulfotransferase.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_AZOC5
Sequence: MSLYEHVFLVRQDVTAQQVEELAARFKGVIEANGGTVSKVEAWGVKSLTYRIKKNRKAHFTLFNIDAPAAAVQEMERQMGIDEDVLRFLTIRVDELEEGPSAMLQKRDRDDRGERGERGFGGGGFGGGRDREDRPRRGRDREEAATEETF
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: LASA_PSEAB
Sequence: MQHKRSRALASPRSPFLFALLALAVGGTANAHDDGLPAFRYSAELLGQLQLPSVALPLNDELFLYGRDAEAFDLEAYLALNAPALRDKSEYLEHWSGYYSINPKVLLTLMVMQSGPLGAPDERALAAPLGRLSAKRGFDAQVRDVLQQLSRRYYGFEEYQLRQAAARKAVGEDGLNAASAALLGLLREGAKASAVQGGNPLGAYAQTFQRLFGTPAAELLQPRNRVARQLQAKAALAPPSNLMQLPWRQGYSWQPNGAHSNTGSGYPYSSFDASYDWPRWGSATYSVVAAHAGTVRVLSRCQVRVTHPSGWATNYYHMDQIQVSNGQQVSADTKLGVYASNINTALCEGGSSTGPHLHFSLLYNGAFVSLQGASFGPYRINVGTSNYDNDCRRYYFYNQSAGTTHCAFRPLYNPGLAL
What is the function of this protein?
Involved in proteolysis and elastolysis (degradation of the host protein elastin).  Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly-|-X substrates where X is Ala or Gly.  Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases.  Degradation of elastin is likely to contribute to the pathogenicity of P. aeruginosa.
What are the official names of this protein?
Protease LasA, Staphylolytic protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M23A family.
What are the subcellular locations of this protein?
Secreted.
Protein: WECG_YERPP
Sequence: MEPNTVIPKYNVRGFEIWGFRDMAQVLDHLLGSGPVKTGTLVAMNAEKLLKAEDDTALCELIKNAEYLYADGISMVRAIRRKYPQAELSRVAGADLWEALMQRAGQQGTPVFLVGGKPDVLAETEAKLRAQWNVNLVGSQDGYFTPEQREALFARIAASGAAIVTVAMGSPKQEIFMRDCRKFYPDALYMGVGGTYDVFTSHVKRAPKIWQNMGLEWLYRLLAQPSRIRRQLKLLKFVGYYYSGRL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: Y1566_ARCFU
Sequence: MYRFNGGGSMKHSIMVWVYVCLAAFTLAGKTLAYDVGAAVAFSEDPEDVWFNSVSQFVEIISSEPTWVQHFLNDYPNVGPYMWTEEEKGNDNFYADYTELSLVLGHGVVVVYPDGTKKSAIGFADRGYALPDDIRLGYASPDGFGYSVWTFIIQCSVLGDEYVDDWLQTLQGVHMVLGFASTATISNADFPELAYRLTGTGGYTREKVESAFFSTFLKSDGVHDDNRARIIAENSEVLDNDYLNSFERVPVDGSKIIVTGWVG
What are the official names of this protein?
Uncharacterized protein AF_1566.
Protein: NHAA2_FRAAA
Sequence: MSQPPPEPGPVRRRTVRRRAIVPGQGRGPGRWSQRLPRGARGADRDGFAAFLRAETTGGLLLLAATVAALVWANTAPGTYHTVWSTPAGLGPSWLHLADMHLTDWVADALLAVFFFTVGLELKRELTLGTLADRRSAALPVAAAAGGMLAPALLCLALTHHTPGAGHAWAIPVATDIAFALGVLSLAGPRVPPGLRTVLLGLAVADDLGGILLIALGLNHGINPAWLATATTLLATTALAHHRRWTSPLLHLPLAAAVWISLHAAGIHPTVAGVALGLLVRVHPDPDEPEAPATRLERHLGPINAAVILPAFALSATGVSLTPHALLHVATDPISRGVAVGLLAGKLLGVPAGAWLAVRLHLARLPDGVRWRHLVPLGLLAGIGYTVSLLITRLALPDPTAVDGASTAILTASVAASALALTALRSPLATVGAPATRGSSRPATQVGGVAGPIPQTRRESDGGPTGGQEPPPARVRRAPPASPHPR
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 2, Sodium/proton antiporter NhaA 2.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NUOK_MYXXD
Sequence: MVPITYYLLLAAALFCMGMFGVLVRRNALVVFMSVELMLNAANLTFVAFARMRGDNLGHVSAFFVIAVAAAEAAIGLAIVIAVFRSRGSILLEDLRTMKH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: QUEE_AGRFC
Sequence: MTEAARNIAARETTVRISEIFGPTIQGEGPLIGLPTVFVRTGGCDYRCSWCDTLHAVDSEYRDTWKPMSVEAIWQEVLGLSGGMPLTVSLSGGNPAIQPLGTLIAKGQGEGYRFALETQGSIAKDWFADLDHLVLSPKPPSSGMETDWQAFEDCLAAAGDGPQVALKVVIFDDADYAYAKAASARFPHLPVYLQPGNHTPPPPDDDDARVDIDGVMDRMLWLVEKISEDRWFSARVLPQLHVLLWGNKRGV
What is the function of this protein?
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
What are the official names of this protein?
7-carboxy-7-deazaguanine synthase, CDG synthase, Queuosine biosynthesis protein QueE.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
Protein: SPLA_STAA1
Sequence: MNKNVMVKGLTALTILTSLGFAENISNQPHSIAKAEKNVKEITDATKAPYNSVVAFAGGTGVVVGKNTIVTNKHIAKSNDIFKNRVAAHYSSKGKGGGNYDVKDIVEYPGKEDLAIVHVHETSTEGLNFNKNVSYTKFAEGAKAKDRISVIGYPKGAQTKYKMFESTGTINHISGTFIEFDAYAQPGNSGSPVLNSKHELIGILYAGSGKDESEKNFGVYFTPQLKEFIQNNIEK
What are the official names of this protein?
Serine protease SplA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1B family.
What are the subcellular locations of this protein?
Secreted.
Protein: MPRIP_HUMAN
Sequence: MSAAKENPCRKFQANIFNKSKCQNCFKPRESHLLNDEDLTQAKPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEGRTGQKFSLCILTPEKEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLSPAQSPSQSQPPAASSLREPGLESKEEESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAEEQQLPPPLSPPSPSTPNHRRSQVIEKFEALDIEKAEHMETNAVGPSPSSDTRQGRSEKRAFPRKRDFTNEAPPAPLPDASASPLSPHRRAKSLDRRSTEPSVTPDLLNFKKGWLTKQYEDGQWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSACYDVTEYPVQRNYGFQIHTKEGEFTLSAMTSGIRRNWIQTIMKHVHPTTAPDVTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWAEFRPIQQALAQERVGGVGPADTHEPLRPEAEPGELERERARRREERRKRFGMLDATDGPGTEDAALRMEVDRSPGLPMSDLKTHNVHVEIEQRWHQVETTPLREEKQVPIAPVHLSSEDGGDRLSTHELTSLLEKELEQSQKEASDLLEQNRLLQDQLRVALGREQSAREGYVLQATCERGFAAMEETHQKKIEDLQRQHQRELEKLREEKDRLLAEETAATISAIEAMKNAHREEMERELEKSQRSQISSVNSDVEALRRQYLEELQSVQRELEVLSEQYSQKCLENAHLAQALEAERQALRQCQRENQELNAHNQELNNRLAAEITRLRTLLTGDGGGEATGSPLAQGKDAYELEVLLRVKESEIQYLKQEISSLKDELQTALRDKKYASDKYKDIYTELSIAKAKADCDISRLKEQLKAATEALGEKSPDSATVSGYDIMKSKSNPDFLKKDRSCVTRQLRNIRSKSVIEQVSWDT
What is the function of this protein?
Targets myosin phosphatase to the actin cytoskeleton.  Required for the regulation of the actin cytoskeleton by RhoA and ROCK1.  Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin.  Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.
What are the official names of this protein?
Myosin phosphatase Rho-interacting protein, M-RIP, Rho-interacting protein 3, RIP3, p116Rip.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Colocalizes with F-actin.
Protein: ENO_DEHM1
Sequence: MSAVVKSIKAREILDSRGNPTVEADVVLSDGSFGRAAVPSGASTGSHEAVELRDGDKSRYNGLGVQKAVTNVNTAIAKAISGFKASDQQGLDNLLIELDGTPNKAKLGANAMLATSLAVAHAAAASCHMPLYRYLNNCDEYILPVPMFNILNGGKHASNSTDFQEFMVMPTGAKSFAEALRMGTEVYHSLKKVLKGMNQNTTVGDEGGFAPSLPTNKDAVEVILKAIEKAGYRPGEDIFIALDPASSELYQDGKYTLATENKTLSSAEMVDYWCGWVEKYPIISIEDGLFEDDWDGWKMLTKKIGSKVQLVGDDFYVTNIKRLERGIKENASNSILIKLNQIGTLSETIAAIKMANNSAWTAVVSHRSGETEDTTIADLAVAMNAGQIKTGAPCRAERTAKYNRLLRIEEELGGKAKYPGKEAFFNLK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ACTP_ECOLI
Sequence: MKRVLTALAATLPFAANAADAISGAVERQPTNWQAIIMFLIFVVFTLGITYWASKRVRSRSDYYTAGGNITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSLGFLVGWPIILFLIAERLRNLGRYTFADVASYRLKQGPIRILSACGSLVVVALYLIAQMVGAGKLIELLFGLNYHIAVVLVGVLMMMYVLFGGMLATTWVQIIKAVLLLFGASFMAFMVMKHVGFSFNNLFSEAMAVHPKGVDIMKPGGLVKDPISALSLGLGLMFGTAGLPHILMRFFTVSDAREARKSVFYATGFMGYFYILTFIIGFGAIMLVGANPEYKDAAGHLIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVFKKGATEREELRVSKITVLILGVIAIILGVLFENQNIAFMVGLAFAIAASCNFPIILLSMYWSKLTTRGAMMGGWLGLITAVVLMILGPTIWVQILGHEKAIFPYEYPALFSITVAFLGIWFFSATDNSAEGARERELFRAQFIRSQTGFGVEQGRAH
What is the function of this protein?
Transports acetate.  Also able to transport glycolate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.