PharMolix/UniProtQA huggingface dataset:
Protein: VP4_ROTRF
Sequence: MASLIYRQLLTNSYTVELSDEIQEIGSTKTQDVTVNPGPFAQTNYAPVNWGPGETNDSTTVEPVLDGPYQPTTFNPPVSYWMLLAPTNAGVVVEGTNNTNRWLATILIEPNVQQVERTYTLFGQQVQVTVSNNSQTKWKFVDLSKQTQDGNYSQHGSLLSTPKLYGVMKHGGKIYTYNGETPNATTDYYSTTNFDTVNMTAYCDFYIIPLAQEAKCTKYINNGLPPIQNTRNIVPVSIVSRNIVYTRAQPNQDIVVSKTSLWKEMQYNRDIVIRFKFANSIIKSGGLGYKWSEVSFKPANYQYTYTRDGEEVTAHTTCSVNGINNFNYNGGSLPTDFVISKYEVIKENSFVYIDYWDDSQAFRNMVNVRSLAADLNSVMCTGGDYSFALPLGHYPVMTGGAVSLHSAGVTLSTQFTDFVSLNSLRFRFRLSVEEPPFSILRTRVSGLYGLPAARPNNSQEYYEIAGRFSLISLVPSNDDYQTPIINSVTVRQDLERQLGELRDEFNNLSQQIAMSQLIDLALLPLDMFSMFSGIKSTIDAAKSMATNVMKRFKKSSLANSVSTLTDSLSDAASSISRNASVRSVSSTASAWTEVSNITSDINVTTSSISTQTSTISRRLRLKEMATQTDGMNFDDISAAVLKTKIDKSTQLNTNTLPEIVTEASEKFIPNRAYRVIKDDEVLEASTDGKYFAYKVETFEEIPFDVQKFADLVTDSPVISAIIDFKTLKNLNDNYGISRQQALNLLRSDPRVLREFINQDNPIIRNRIESLIMQCRL
What is the function of this protein?
Forms the head of the spikes and mediates the recognition of specific host cell surface glycans.  It is the viral hemagglutinin and an important target of neutralizing antibodies.  In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.  In some other strains, VP8* mediates the attachment to histo-blood group antigens (HBGAs) for viral entry.
What are the official names of this protein?
Outer capsid protein VP4, Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP4 family.
What are the subcellular locations of this protein?
[Outer capsid protein VP4]: Virion. Host rough endoplasmic reticulum. Host cell membrane. Host cytoplasm, host cytoskeleton. Host endoplasmic reticulum-Golgi intermediate compartment. Note=The outer layer contains 180 copies of VP4, grouped as 60 dimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple- layered particles. VP4 also seems to associate with lipid rafts of the host cell membrane probably for the exit of the virus from the infected cell by an alternate pathway. SUBCELLULAR LOCATION: [Outer capsid protein VP8*]: Virion. Note=Outer capsid protein. SUBCELLULAR LOCATION: [Outer capsid protein VP5*]: Virion. Note=Outer capsid protein.
Protein: MHPB_RHORH
Sequence: MTQALLCMSHSPLLDHATPPAEVKSAVDDAFARARDFVEAFDPELVVNFGPDHFNGFFYDLMPPFCIGYRAHGTGDYDSFAGDLDVPEDVAADLAQFVLDHGSDVAISRHMEVDHGAVQPMEILHGGDAGARPILPVFVNSIARPFVPMSRVRAFGHAVGDFFAGTDKRVLFLGSGGLSHDPPVPQFATATASQREFLTSGRNPPPEARPARQARTIETARRFAAGEAEIMDLNPEWDRAFLDVCRSGRVEDFDRYTADEMDAAAGHSSHEVRTWVAAYSALRACGEYDVTYEFYRPIKEYIAGFAVTTAQLAGEA
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: HIS7_MICAN
Sequence: MISTSQIPDSFVSPCRRASVSRTTKETDVQVTIDLDGSGNCRAQTGIPFLDHMLQQIASHAAIDLDVRATGDIEIDDHHTNEDVGITLGQALLQALGDKKGIVRFGHFVAPLDEALVQVALDFSGRPHLSYGLEIPTQRVGTYDTQLVREFFVALVNHSQMTLHIRQLDGINSHHIIEATFKAFARAMSMAIAIDPRRAGIIPSSKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_STRCO
Sequence: MAKKQGAIEIEGTVVESLPNAMFKVELQNGHQVLAHISGKMRMHYIRILPDDRVVVELSPYDLTRGRIVYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDCC_XANC8
Sequence: METLRYRFDGRNGARTGLDHALVGVVASGNLEVLVERVPLGGAMEIEIVTAARGFGEIWQAVLDDFAARHSLQDVRISINDVGATPAVVSLRLEQAIDVLQGADA
What is the function of this protein?
Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.
What are the official names of this protein?
Malonate decarboxylase acyl carrier protein, Malonate decarboxylase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the MdcC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_PSEAE
Sequence: MIQTQSMLDVADNSGARRVMCIKVLGGSHRRYAGIGDIIKVTVKEAIPRGKVKKGQVMTAVVVRTKHGVRRTDGSIIRFDGNAAVLLNNKQEPIGTRIFGPVTRELRTEKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: Y2272_MYCTO
Sequence: MADDSNDTATDVEPDYRFTLANERTFLAWQRTALGLLAAAVALVQLVPELTIPGARQVLGVVLAILAILTSGMGLLRWQQADRAMRRHLPLPRHPTPGYLAVGLCVVGVVALALVVAKAITG
What are the official names of this protein?
Uncharacterized protein MT2333.
What is the protein family that this protein belongs to?
To E.coli YidH.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y4JJ_SINFN
Sequence: MANVTVRNLPDEVHRALRVRAAMHGRSTEAEIRDILETTVRPPERVKLGSLLASIAHEAGGLTDAEAEHFNQLRDKTPAEPMSFE
What is the function of this protein?
Involved in plasmid stability.
What are the official names of this protein?
Putative plasmid stability protein y4jJ.
What is the protein family that this protein belongs to?
To P.syringae pv tomato plasmid stability protein StbC.
Protein: RS19_FRATO
Sequence: MPRSLKKGPFVDHHLLKKVFEAQESNSKKPIKTWSRRSMIVPDMIGLTIAVHNGQQHVPVLMTEEMVGHKLGEFVVTRNYRGHAADKKAKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SYA_ARATH
Sequence: MRLVKAASLLISSTKPPSRVFYSSHLRRPFFSHFRFSSSSSTSSSVAVMPGSEPSETQWPAKRVRDTYVDFFRGKGHKFWPSSPVVPHNDPTLLFANAGMNQYKPIFLGTADPNTELSKLSRACNTQKCIRAGGKHNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKEAIEWAWELLTKVYGLPTDRIYATYFGGDEKAGLQPDNEARDIWLKVLPSGRVLPFGCKDNFWEMGDTGPCGPCTEIHYDRIGNRDAASLVNNDDPTCLEIWNLVFIQFNRESDGSLKPLPAKHVDTGMGFERLTSVLQNKMSNYDTDVFMPIFDDIQKATGARPYSGKVGPEDVDRVDMAYRVVADHIRTLSFAIADGSRPGNEGREYVLRRILRRAVRYGKEILKAEEGFFNGLVSSVIRVMGDVFTELKEHEKKITDIIKEEEASFCKTLAKGIEKFRKAGQAVQGNTLSGDDAFILWDTYGFPLDLTQLMAEERGLLVDVDGFNKAMEEARERSRSAQNKQAGGAIVMDADATSTLHKAGVSATDDSFKYIWFQDHESELKAIYTGSTFLESSAASDNVGLVLGSTSFYAEQGGQIFDTGLIEGSFGTFNVCNVQIFGGFVLHIGYLSKETGEVSVGDKVICKVDYERRKLIAPNHTCTHMLNYALKEVLGDHIDQKGSIVLPEKLRFDFSHGKPVDPEDLRRIESIVNKQIKDELDVFSKEAVLSEAKRIKGLRAVFGEVYPDPVRVVSIGRKVEDLLADPENNEWSLLSSEFCGGTHITNTREAKAFALLSEEGIAKGIRRVTAVTTECAFDALNAASLLEREVEDASRAEGSALEKKVSALKSRVDAAIIPAAKKADIRTKIASLQNEVRKAQKKIAEQNLKKSVKLATEAAESAASDGKTFCIIQLDVGLDAAAVREAVSKVMEKKGMSIMVFSTDESTNKAVVCAGVPEKSDQFKPLDVTEWLTTALGPLKGRCGKGKGGLASGQGTDASQVQAALDMASSFASMKLN
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: SEPF_CALS8
Sequence: MFDNLQRKFLNLIGIEIEEEDKPQESTKAKEENVKPKHETPKVVTIGKANQTEVTVYNLKLFDEVVKVCDALRENKIVVFNLEQVAEDHIQRIIDFVSGAVYVLDAKIHKVSKKIFVVVPRSIDLEVDEQLKEEFRTKGVFAWLK
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: CIA84_NEUCR
Sequence: MRSHLARNATTTTPNVYRRLHAAVGHHHGLLRPCSATALSARRCLFDCQHDVAHIPRDVALCTRTSKRTFISLFTPKPERFVKLPHFDPGYNVLLQYRKSEVEQERPPPRDQLVTAFKKLTKFKADTNRPLNPNQAFLLRTVLHYLLVTKPEADAPVDLKMSDLENAMDAALLPPKGSPEFHLALARLLHEEIMRRRLILLNPEERKVHLTKDDFARYIKALTQYGGSLEAAGRVKEFWQQLKDERSAVYFRGSGRIWIMVLEGLANEGREEELLQFWEEAQETGGIKYIPGVHQIFVTYYARQDKIEETKQWYSKPIHSGFSPTGETLLELVRSSRRSSQKWNEWLLPVFEQVVQDKFAKKGSLDAFLQWSVLALDKGPDGIKTYLQTMASGDFYQSHEVKVDATTINRLMQAAQEKGNPYMAERFWQLAQDFNIKANVHTYLNQMSYRLDANDIEGAHQIFSKLASGAVEVEFDEDLPVMNKYLRVLCAQQEPNIQHILTITSALEQRHAVLEPETIVALCLVFLNHDKKFDVIDTLSLHSVSISHIERQQIYKAFVDYICSPQTTTDRAWDAYSLLRQYFPETSVDDRVRLMESFFERKKPDMACLVFGHMRAHDDDNMHPTADIYVRCLEGLGRCPIPEQRPSDPASSLKMVHNMLKMDTRVEMNTRLYNALMLAYAAGGDPFTALDFWEEHITRSAEGPSYNSLAIVFWCCELIPLGDRYARPVWQKMLRMDLEVPQLGLTYNALPDPVSKDEFAAWAKEEYPEEWARLESKGQKETEFQGPVFNITRLFEA
What is the function of this protein?
Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
What are the official names of this protein?
Complex I intermediate-associated protein 84, mitochondrial.
Protein: NADK_CLOBB
Sequence: MKNIGIAINPSKDYKNTILNMVKEKIKNICNITDIEVYNSFDIKNLNLSSLDLLIVLGGDGTLLGVARELDDDFKAPILGINIGNLGVLSSIEISDLELALKKLMTKDCKVHKRMMLNCEVDINESIKNIKALNEVAVARGTLSRMVKFKIFVDEKLYAIFKGDGLIVSTPTGSTAYSFSAGGPFICPDLEVISIVPICDHTKSMHPIVLKGDSTIKIIAQNGGDQIYLTIDGQRAIEMKDNSVITVKKNPKSLKLLLFNDYDYFKVIRNKVLNNSKECDGEKN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_BARQU
Sequence: MAQKERGERDERDGEFVDRLVHINRVAKVVKGGRRFGFAALVVVGDQKGRVGFGHGKAREVPEAVRKATEAAKRGMIYVPLRSGRTLHHDLEGRHGAGRVLLRSASAGTGIIAGGPMRAIFETLGMQDVVAKSLGSSNPYNMVRATFDALKHQMHPRDIAVQRGIKYSILQARRQHLVDAEG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: TIM14_CAEEL
Sequence: MTGGLIVAGLGLAAVGFGARYVLRNQALIKKGMEAIPVAGGAFSNYYRGGFDQKMSRAEAAKILGVAPSAKPAKIKEAHKKVMIVNHPDRGGSPYLAAKINEAKDLMESSKS
What is the function of this protein?
Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.  May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM14, DnaJ homolog subfamily C member 21.
What is the protein family that this protein belongs to?
Belongs to the TIM14 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: SYR_LISW6
Sequence: MNVMQENQIKLIEHIKQAVVQAVGLPEVEVPEILLEVPKDKKHGDYSTNIAMQLARVAKKAPRQIAESIVPELKKDNKLIKEVEIAGPGFINFYLDNAYLTELVPVILTEDHKYGESDFGKGEKFQIEFVSANPTGDLHLGHARGAAIGDSLANIMKMAGFDVSREYYINDAGNQINNLVLSAEARYFEALGLESEFPEDGYRGADIISLGKDLAAKYGDKYVNTSEEERRSVFRVDALAFETGKLRADLEEFRVSFDEWFSETSLYEENKVLPALERLRENGYIYEQDGATWLRTTDFEDDKDRVLIKSDGSYTYFLPDIAYHLNKLERGFDVLIDIWGADHHGYIPRMRAAIEALGYSPNQLEVEIIQLVHLFEDGVQVKMSKRTGKSVTMRDLIEEVGLDATRYFFAMRSSDTHMNFDMSLAKSTSNDNPVYYVQYAHARISSILRSGKEQGLEVTKDADMSLLQTEAEYDLLKVLGEFADVVAEAAAKRAPHRIVRYLNDLATAFHRFYNSNKVLDMDNLEVTQARLSLIKTAQITLRNGLTLLGVSAPEKM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAB5_PYRAB
Sequence: MRRGAIGIGTLIVFIAMVLVAAVAAGVLISTSGYLQQRAMSVGLETTRDVSSGLRIISIWGYAPKNTTGNTTIQSNITKLAIYIAPNAGSEPINLNQTRIILTVKSTMVIFTFGGEDTVADWTNGAVNVFNETIWENINGTKFGVGVVVDSDKSMLSNKASPGMNSGDLAVLLINTKLAFNKYGGIPPNTKVVGKILPPHGAGTVIDLITPATYSSEGIELQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
What are the official names of this protein?
Flagellin B5.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: QCR2_CANAL
Sequence: MLSRASIRAYSSIPNSVKIAAKESATDLTKLSVIINNAGSKTGKSGVSHLLSKFTFLNNGAKSALRFTRESELLGGTFESKVTRDALILNTTFLKQDLPYYVEALGNVVSNTQFAPHEFNEIVLPTANAETKLANANPAFKGVEKLHEITFRRGLGNPLFYNESTPIKLEEVAQFSKEQFSGENISIVAEGANEEDLTKFVSESAFCYLPSSSSNGAKALPTNTFTGQEARVPSSGASSALIGIPVKPADFGKYEVLSAAIGTSTLPSTSTPLAQIPGATSHLYKYQDAGLFVISVSGEASQVAQGIKQAKSVAESVSSSALSEAVKAAELSVALQSTVDSPLNVKVVAEEAPISKFNYVAVGDLDVLPYADEL
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 2, mitochondrial, Complex III subunit 2, Core protein II, Cytoplasmic antigenic protein 5, Ubiquinol-cytochrome-c reductase complex core protein 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: NCAP_MACHU
Sequence: MAHSKEIPSFRWTQSLRRGLSQVHPTVKTDVLKDAKLIADSIDFNQVSQVQRALRKNKRGEEDLNKLRDLNKEVDRLMSMKSIQKNTIFKIGDLGRDELMELASDLEKLKNKIKRTESGPQGLYMGNLSQLQLTKRSEILKTLGFQQQRGAGNGVVRIWDVSDPSKLNNQFGSMPALTIACMTVQGGETMNSVVQALTSLGLLYTVKYPNLNDLDKLTLEHECLQIVTKDESSINISGYNFSLSAAVKAGASILDGGNMLETIRVTPDNFSSLIKSTLQVKRKEGMFIDEKPGNRNPYENLLYKLCLSGDGWPYIGSRSQILGRSWDNTSVDLTKKPQVGPRQPEKNGQNLRLANLTEMQEAVIKEAVKKLDPTNTLWLDIEGPPTDPVELALYQPANKHYIHCFRKPHDEKGFKNGSRHSHGILMQDIEDAMPGVLSYVIGLLPQDMVITTQGSDDIRKLLDIHGRKDLKLVDVKLTSDQARLYDQQIWEKFGHLCKHHNGVVVNKKKREKDSPFKLSSGEPHCALLDCIMYQSVMDGKMVDEEPVALLPLSLLFLPKAAFAL
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  The encapsidated genomic RNA is termed the nucleocapsid (NC).  Serves as template for viral transcription and replication.  The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses.  Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation.  Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: PHL1_LEPIC
Sequence: MITKRNIPCKKNWKYKKKSISLTLITICYMFLFLTSCKPGKQNSINLLLLLLNTLDNKNVNEKIEDSTNTDPSSNVNEEDENSINANANDNAPSDSDSSNPRSPDKNPVNPTSPNSSSADIGIKILSHSIFMAPTNLSSWGDLGQEERAQRIASSSYIKNQDIIVFEGLSHNNAEKILLEKIRSEYPYQTNVVGRTKKGWNATLGAYTTSPMANGGVIIVSKWPIEEKVQYIFNNSNCGQDQYYNKGFAYVKINKDGKKFHVIGTQLQAREPDCFNSGETIRKLQLNDIKSFIDSKDIPKDETVLITGDLNIIKGSNEYFDMISKLNVNEPRYVGVPFTLDTKTNALAAYYYEKEKPIYLDYILVSKLHAQPPVWQNLAYDPISNTTWKRSDGYTSYEFSDRYPVYGFIYADSSTPTKSGHKRKYDQVSFQSTFNRKFIQADHNKKDGWLKADTRIKTDFTKFNLLQENVSESNPSCMNSGSVRIESSYYLNYYWNWFIGAASGDYGYYTKFNNGSDSLGIKNLDNGCLKDGSRVAFYDWDTIGGGYYYLTVWDKGSWKEHLFLWVQSFLSSREIFYLHLDSNPPKDWSKDLIYHH
What are the official names of this protein?
Sphingomyelinase C 1, Sphingomyelin phosphodiesterase 1, SMase 1.
What are the subcellular locations of this protein?
Secreted.
Protein: NHAB_SHEB2
Sequence: MPATMSQAFIGNFLGNSPKWYKTAILSFLIINPLLFFYVDPFVAGWVLVLEFIFTLAMALKCYPLQPGGLLAIEAVAIGMTSASQVLHEIEANLEVLLLLVFMVAGIYFMKQLLLFGFTKIITKVRSKVLVSLMFCLASAFLSAFLDALTVIAVIIAVAVGFYSIYHKVASGKDFGADHDHTSEGKNAAGEDQLNEEELGAFRGFLRNLLMHAGVGTALGGVCTMVGEPQNLIIAAQANWQFGEFAVRMSPVTVPVLISGILTCYLVEKFGIFGYGAKLPTAVHRILCEYAAHEDARRTNKDNMKLIVQALVGVWLIAGLALHLASVGLIGLSVIILTTAFNGVTDEHALGKAFEEALPFTALLAVFFAVVGVIIDQHLFAPVIQWALGYEGNTQLVIFYIANGLLSMVSDNVFVGTVYINEVKAALINGQITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLSIVGVMAIQTGFLEQATQYFYDSHTIIHHSAKEVLGTVSGH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYN3_RAT
Sequence: MNFLRRRLSDSSFVANLPNGYMPDLQRPESSSSSPASPATERRHPQPLAASFSSPGSSLFSSFSSAMKQTPQAPTGLMEPPTPVTPVVQRPRILLVIDDAHTDWSKYFHGKKVNGDIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKIVRSFKPDFILVRQHAYSMALAEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPNFPVVIKLGHAHAGMGKIKVENQHDYQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKNGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVVSKMSQLLVPGASVPSPLRPWGPQTKSAKSPGQGQLGPLLGQPQPRPPPQGGPRQAQSPQPPRSRSPSQQRLSPQGQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPTASLSSHTRPPVQGRSTSQQGEEPQKTASPHPHLNKSQSLTNSLSTSDTSHRGTPSEDEAKAETIRNLRKSFASLFSD
What is the function of this protein?
May be involved in the regulation of neurotransmitter release and synaptogenesis.  Binds ATP with high affinity and ADP with a lower affinity.  This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed.
What are the official names of this protein?
Synapsin-3, Synapsin III.
What is the protein family that this protein belongs to?
Belongs to the synapsin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
Protein: RL5_ANAMM
Sequence: MYMLGSLCKEAVAQSLMSKLGCSSVMQVPKVVKVCLNMGIGIGAMDSKVMDSCSRDLALISAQKPVVTRARRSIAGFKIRKGFPIGCMVTLRGKKMYEFLDRLINIALPRERDFKGLSMSQFDGHGNISFGVKEHISFLEVDYDKIDKVRGFDVSVVTTAKSDYDAKALLTELGFPFVN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RUVB_PSEPF
Sequence: MIEADRLIAATHSPREREEVQDRAIRPVSLAEYIGQPTVREQMELFIQAARGRSESLDHTLIFGPPGLGKTTLANIIAQEMGVSIKSTSGPVLERPGDLAALLTNLEPHDVLFIDEIHRLSPIVEEVLYPAMEDFQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGMLTNPLRDRFGIVQRLEFYSTADLATIVSRSANILGLPLDPEGSFEIARRARGTPRIANRLLRRVRDFAEVRAKGHITKSVADLALNLLDVDEHGFDHQDRRLLLTMIEKFDGGPVGIDSLAAAISEERHTIEDVLEPYLIQQGYIMRTPRGRVVTRHAYLHFGLNIPTRMGEMPVVDEFLDAVDD
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL7_BURP6
Sequence: MAIAKEDILAAVEGMTVLELNELVKAFEEKFGVSAAAVAVAGPAAGGAAAAAEEKTEFTVVLAEAGSNKVAVIKAVREITGLGLKEAKDLVDGAPKPVKEGVDKASADEAKKKLEDAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.