PharMolix/UniProtQA huggingface dataset:
Protein: TRAA_SINFN
Sequence: MAVPHFSVSVVARGSGRSAVLSAAYRHCARMDYEREARTIDYRAKQGLLHEEFVIPAESPEWLRSMIADRSVASASEAFWNKVEDFEKRSDAQLAKDVTIALPIELTTEQNIVLVRDFVERHVTAKGMVADWVYHDAPGNPHVHLMTTLRPLTADGFGAKKLAVVGPDGNSLRNDAGKIVYELWAGSLDDFNAFRDGWFACQNRHLALAGLDIRIDGRSFEKQGIELTPTIHLGVGTKAIERKATTDDQAVSLERLELQEEKRAENARRIQRRPEIVLDLITREKSVFDERDVAKILHRYIDDPGVFHSLMARILQSPKTLRLERERIAFATGIRAPAKYTTRELIRLEAEMGSRAIWLSRRSSHGVRKEVLEAAFSRHSRLSDEQKTAIEHVAGAERIAAVIGRAGAGKTTMMKAAREAWEAAGYRVVGGALAGKAAEGLEKEAGIASRTLSSWELRWNEGRKQLDDKTIFVLDEAGMVSSRQMALFVETATKAGAKLVLVGDPEQLQPIEAGAAFRAIADRIGYAELETIYRQREQWMCDASLDLARGNVGKVVDTYRANGRMMRSELKAEAVQNLIADWDRDYDPTKTTLILAHLRRDVRMLNQMARAKLVERGIVDAGFSFKAEDGNRRFAPGDQIVFLKNEGALGVKNGMRGKVVEAAQNRIVAEIGEVEHRRQVMVESRFYNNLDHGYATTIHKSQGATVDRVKVLASLSLDRHLTYVAMTRHREDLGVYYGARSFAKSGGLIQILSQKNSKETTLDYEKATFYRQALRFAEARGMHLVNVARTIARDRLEWTVRQKQKLADLTQRLVAIGARFGLAVGAKTTNSQNLKETRPMVAGIATFPKSMEQAVADRLEVDPGLKKQWEDVSTRFHLVYTQPEVAFKAVNVDAMLKDETVAKSALSNMANQPESYGSLKGKTGLLASRADKQDRERAERNVPALAQSLSDYMRQRSRAEQCYQADELAVRRKVAIEIPALSPGARQTLERVRDAIDRNDLPAALEFALADRQVKAELEGFARAVTERFGERAFLPLAAKDTNGETFKTITAGMNPGPKAEVQSAWNTMRTVQQLNAHERTIEALKQAETLRQTKSQGLSLK
What are the official names of this protein?
Probable conjugal transfer protein TraA.
What is the protein family that this protein belongs to?
Belongs to the MobA/MobL family.
Protein: BSR_PSEPU
Sequence: MPFRRTLLAASLVLLITGQAPLYAAPPLSMDNGTNALTVQNSNAWVEVSASALQHNIRTLQAELAGKSRLCAVLKADAYGHGIGLVMPSIIAQGVPCVAVASNEEARVVRASGFTGQLVRVRAASLSELEDALQYDMEELVGSAEFARQADAIAARHGKTLRIHLAFNSSGMSRNGVEMATWSGRGEALQITDQKHLELVALMTHFAVEDKDDVRKGLAAFNEQTDWLIKHARLDRSKLTLHAANSFATLEVPEARLDMVRTGGALFGDTVPGRTEYKRAMQFKSRVAAVHSYPAGNTVGYDRTFTLARDSRLANITVGYSDGYRRVFTNKGHVLINGHRVPVVGKVSMNTLMVDVTDFPDVKGGNEVVLFGKQAGGEITQAEMEEINGALLADLYTVWGSSNPKILVD
What is the function of this protein?
Amino-acid racemase that catalyzes the interconversion of L-lysine and D-lysine, and L-arginine and D-arginine (PubMed:23118975).  To a lesser extent, is also able to interconvert alanine and isoleucine enantiomers (PubMed:23118975, PubMed:22806802).
What are the official names of this protein?
Broad specificity amino-acid racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family. Bsr subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: ALLB_SALHS
Sequence: MSFDLIIKNGTVILENEARVIDIAVQGGKIAAIGENLGEAKNVLDATGLIVSPGMVDAHTHISEPGRTHWEGYETGTRAAAKGGITTMIEMPLNQLPATVDRETIELKFDAAKGKLTIDAAQLGGLVSYNLDRLHELDEVGVVGFKCFVATCGDRGIDNDFRDVNDWQFYKGAQKLGEMDQTVLVHCENALICDELGEEAKREGRVTAHDYVASRPVFTEVEAIRRVLYLAKAAGCRLHVCHISSPEGVEEVTRARQEGQDVTCESCPHYFVLDTDQFEEIGTLAKCSPPIRDQENQKGMWEKLFNGEIDCLVSDHSPCPPEMKAGNIMQAWGGIAGLQNCMDVMFDEAVQKRGMSLPMFGKLMATNAADIFGLKHKGRIAPGKDADLVFIQPDSSYVLKNEDLEYRHKVSPYVGRTIGARITKTILRGDVIYDIEHGFPVPPKGQFILKHQQ
What is the function of this protein?
Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
What are the official names of this protein?
Allantoinase, Allantoin-utilizing enzyme.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
Protein: RECO_LISMH
Sequence: MEKCEGIVIRQTSYRESDKIVRMYTREFGKIGVVARGAKKTKSRLAAVTQLFTNGYFTFFGGNGLGTLQQGEVIETFSSIQQDIFMTAYATYVCELLDKATEERQPNPYLYELTFQILRDIDEGYDPQILTQIYEMKMLPVLGLYPTMDKCAICGETTGHFDFSTSSNGIICHRCFEKDRYRMHLPENVVKLLRLFFIFQLDRLGNIDVKQETKDWLQKAIDTYYDEYSGLYLKSRKFIREMDKWENMLKKDSDD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: LACD2_STRA3
Sequence: MVLTEQKRKYMEKLSDENGIISALAFDQRGALKRLMAQYQEAEPTVEQMEDLKVLVAEELTPYASSMLLDPEYGLPATKALDKNAGLLLAYEKTGYDTSSTKRLPDCLDVWSAKRIKEQGSDAVKFLLYYDVDSSDELNQQKQAYIERVGSECVAEDIPFFLEILAYDEKIADAGSAEYAKVKPRKVIEAMKVFSDSRFNIDVLKVEVPVNVKYVEGFGDGEVIHTRGEAAAFFKQQDEATNLPYIYLSAGVAAKLFQETLIFAHESGANFNGVLCGRATWAGSVKEYIEQGEEAARQWLRTTGYQNIEELNQVLKQTATSWKERV
What are the official names of this protein?
Tagatose 1,6-diphosphate aldolase 2, D-tagatose-1,6-bisphosphate aldolase 2, Tagatose-bisphosphate aldolase 2.
What is the protein family that this protein belongs to?
Belongs to the aldolase LacD family.
Protein: RS7_SYNSC
Sequence: MSRRNAAEKRPILPDPQFNSRLATMMVVRLMQHGKKSTAQRILSDAFGLINERTGGDPLELFETAVKNATPLVEVRARRVGGATYQVPMEVRQERGTAMALRWLVSFSRARNGRSMAQKLAGELMDAANEAGNAVRKREETHKMAEANKAFAHYRY
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: NGFV_CRODU
Sequence: MSMLCYTLIIAFLIGIWAAPKSEDNVPLGSPATSDLSDTSCAKTHEALKTSRNIDQHYPAPKKAEDQEFGSAANIIVDPKLFQKRRFQSPRVLFSTQPPPLSRDEQSVDNANSLNRNIRAKREDHPVHKRGEYSVCDSVNVWVANKTTATDIRGNLVTVMVDVNINNNVYKQYFFETKCRNPNPVPTGCRGIDARHWNSYCTTTNTFVKALTMEGNQASWRFIRIDSACVCVISRKNENFG
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor, v-NGF, vNGF.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: DDL_BART1
Sequence: MKDKHIAVLMGGFSSERSISLSSGAACADVLEEQGYRVSRVDVGAHIASVLEQLQPDIAFNALHGPFGEDGRIQGILEYLKIPYTHSGVMASALAMDKGRAKIIAANAGVCVAPSRIMNRFSIGKTHPMEPPYVIKPVCEGSSFGVVIVQENEAVPPHNIGGSEWGYADEVMVEKYIPGRELTCAVLGNEVLDVCEILPDQHFAFYDYDSKYKTGGSLHICPAKLSLNIYQSVQRMSLAAHQAIGCRGVSRSDFRFDEKTGELVWLEINTQPGMTSTSLLPDIAKASGRTYGDIVQWMVEDASCMR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRC22_CANDC
Sequence: MKLSTIFTVFAATIATVAGYETTGSKQTVDILIDYVIKETPELSQNDVANWENGDTVTLQYVVNNNEETEITVVGVTGQFKNPINNEIVTNLTTGKVGPIAVPPGEAIKFDQKINVDLIPANYELIPHVFIAQDSLIKVIPCRGQLATIVDAAVSFFDPRLIFLELVLLVTFAGLLYVGYEIWGKQYFKSVAPVKAKKTSTKASSPVASASTSAATGYDTNWIPESHLKQKKTKKVN
What is the function of this protein?
Is probably involved in a pathway contributing to genomic integrity.
What are the official names of this protein?
Increased recombination centers protein 22.
What is the protein family that this protein belongs to?
Belongs to the IRC22 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: SYA_METKA
Sequence: MKVDPSEFELEFFEEIGFERKRCPECGEYFWGPPEAEVCNETPCVEYSFIGDPPASVKLDVWEAGEEFFRFFERHDHEVLDRYPVVARWRDDIHLTIASIACFQPWVTSGEVPPPANPLVINQPCIRLNDIDNVGRTGRHFTLFHMGGHHAFNNHPHDRRDIYWKEETVRLCYEFTVEKLGIPEEKIAFKESWWEGGGNAGPCFEVVVDGLELATLVFMQYEQVGGEYRELPQKIVDTGYGIERYAWITTGEPTAYDAVFGDLVDATARDLGVEIDGEAREILGELARVAGLMDVETESDLRVLRNRVARRLDLDVNELVRVAEPVEFVYGILDHARCLAFMLGDGVVPSNAGEGYLARLVIRRALRLLDGLDAEREYLLEVVERVLEDLRGTYPELAEREEYIQDALECEIDRYTRALKRGKKEVRKRLEEKGELSFEDLVELYDSHGIPPEVAREIAEDEGVEVEVPDDFYSRVAERHEGPEEVEEGLEELERIAVEEELPETELAFYDDEKRLEFKAEVIGTYEVNGDAWVVLDRTYFYPEGGGQEADRGTMRWKDGEAEVKDVQKVRGVVFHRIDGDVPPEGAEVECEVDGERRMRLTRNHTATHVILEAARRVLGDHVWQAGAHKSTDEARLDVTHHRRISDEELREIERLANEIVMKDLPVNKRFMDRNEAERRYGFELYQGGVVPGREIRVVEIEGWNVQACAGTHCDSTGEIGPIKIVGRERIQDGVERIRFAAGEAALERIWETEDLLRETCEVLRVNPENLPKTVKRFFEEWKEQRKRIERLERELVEAKLRAAPAEGRRVGDFTVTLVELEDVEVGSVAGTVEELVKEHENLVLVAKIVSNGSCQVVVGSGESAPPAGELMREIGKLIEGGGGGDERLAQGGGRNPDGLTEDRLVEIVEDLAGG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASIP_MACFU
Sequence: MDVTRLLLATLLVFLCFFTAYSHLPPEEKLRDDRSLRSNSSVNLLDFPSVSIMALNKNSKEISRKEAEKKRSSKKEASMKKVARPRTPLSAPCVATRDSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMP_BACSU
Sequence: MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKSPGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLATARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPVVRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKTDLNLYVPLYGQAESLNVAVAAAILVYHLRG
What is the function of this protein?
Specifically methylates the ribose of guanosine 2553 (G2553) in 23S rRNA (PubMed:35710145).  When the target G2553 is mutated, is able to methylate the ribose of adenosine, but it cannot methylate cytidine nor uridine (PubMed:35710145).  Modifies free 23S rRNA but not the fully assembled ribosome nor the 50S subunit, suggesting that the modification occurs early during ribosome biogenesis (PubMed:35710145).
What are the official names of this protein?
23S rRNA (guanosine(2553)-2'-O)-methyltransferase RlmP, 23S rRNA (guanosine-2'-O-)-methyltransferase RlmP.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: KGUA_STRT1
Sequence: MSERGLLIVFSGPSGVGKGTVRQEIFSKSDHKFEYSVSMTTRAQRPGEVDGKDYFFRSREEFEELIRNGQMLEYAEYVGNYYGTPLAYVNETLDKGIDVFLEIEVQGALQVKKKVPDAVFIFLTPPDLNELEERLVGRGTDSEEVIAQRIERAREEIALMSEYDYTIVNDEVPLAAERVKRVIEAEHFRVERVIGHYRNMISDKRLSDK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM51_MOUSE
Sequence: MAGSVPWAASRRLWGWVPSACRSFSLGVPRLAFVRLTLPPPKVVDRWNEKRALFGVYDNIGILGNFEKHPKELIKGPVWLRGWRGNELQRCVRKKKFVGNRMFIEDLHNLNKRISYLYKHFNRHGKYR
What are the official names of this protein?
39S ribosomal protein L51, mitochondrial, L51mt, MRP-L51, bMRP-64, bMRP64.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL51 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YBEY_YERPE
Sequence: MSQVILDLQIACADSQGLPTEGDFQRWLEAVLPLFQPVSEVTIRLVDEAESHDLNLTYRGKDKSTNVLSFPFEAPPEIELPLLGDLIICRQVVEKEAIEQEKALLAHWAHMVVHGSLHLLGYDHIDDEEAEEMELIETEIMHGLGYPDPYISEKDPD
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FXRD1_HUMAN
Sequence: MIRRVLPHGMGRGLLTRRPGTRRGGFSLDWDGKVSEIKKKIKSILPGRSCDLLQDTSHLPPEHSDVVIVGGGVLGLSVAYWLKKLESRRGAIRVLVVERDHTYSQASTGLSVGGICQQFSLPENIQLSLFSASFLRNINEYLAVVDAPPLDLRFNPSGYLLLASEKDAAAMESNVKVQRQEGAKVSLMSPDQLRNKFPWINTEGVALASYGMEDEGWFDPWCLLQGLRRKVQSLGVLFCQGEVTRFVSSSQRMLTTDDKAVVLKRIHEVHVKMDRSLEYQPVECAIVINAAGAWSAQIAALAGVGEGPPGTLQGTKLPVEPRKRYVYVWHCPQGPGLETPLVADTSGAYFRREGLGSNYLGGRSPTEQEEPDPANLEVDHDFFQDKVWPHLALRVPAFETLKVQSAWAGYYDYNTFDQNGVVGPHPLVVNMYFATGFSGHGLQQAPGIGRAVAEMVLKGRFQTIDLSPFLFTRFYLGEKIQENNII
What is the function of this protein?
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554).  Involved in mid-late stages of complex I assembly (PubMed:25678554).
What are the official names of this protein?
FAD-dependent oxidoreductase domain-containing protein 1.
Protein: UPPP_GEODF
Sequence: MDLFQATILGIVQGLTEVLPISSSAHLILIPTFLKWPESGITFDVALHLGTFIALCLYFWRDLIELASDFFTGMADWKHQPTSRRLPFYIIAGTFPAAIVGKLFETTIEELFRKSPSLIALFLIVFALLLAFADTSGSKKWKIEAITLKSAIIIGLAQCLALIPGVSRSGITITAALLLGFNREAAARFSFLLSLPIVAGAALFELSGLLKTGIPPSDVAPLLIGIATSAVFGYISVAFLLKMVQRSSLYPFVWYRIAIGCLALVFINFG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACCD_RHOBA
Sequence: MEMDTAVENPAVEKNGQPTPSSTSTATDAAPTPNAPNRPAPNTAGNRKRGVPEGVWRKCDSCGASLFYKEVQQRLNVCPQCDHHFYVSAWERVAQVLDDGTFEPMNEHLRPTDPLEFRDRRSYAERLVGEQKRTGLTDAVLTGTGMIRARRVAFAVTDSAFIMGSMGSVVGERLTRLIERATEQNLALIIISASGGGARMHEGILSLMQMAKVSAALSRYHAAGGLFISVLTNPTMGGVAASFASLGDLVFAEPKALIGFAGPRTIKATIGIELPEGFQTSEFLLEHGYIDRIVHRKSLKTEIATAIDYCGK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUI1_MIMIV
Sequence: MLNRIIYDPFNDGLDTEQHFEKIHIKTKQRTKTKSITIIENIPEKIDLKLFLKKLKYTFHCSGSIQQNYDDDSKFIQLSGDHRELVKNFLIKNSIVKESNIVMHGY
What is the function of this protein?
Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.
What are the official names of this protein?
Protein translation factor SUI1 homolog.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: SCONB_PENRW
Sequence: MADRPEPSSTQQSLVVPDAGVSANADSNRSLPRKDTDNTTQTLEELARQNVAPFLAKYQPRQYAPLRSQVSAPSERHMVNAGYCYRHQPDSKCSRRQADEQSMTQLQSELNLLPQSDQQGIAHVWSLFSAAPAKQRTLMLQGILAQSCFPQLSYISASVRELIRIDFLAALPPELSFKILRYLDTASLCRAAQVSPRWRALADDDVVWHRMCEQHIRRKCNKCGWGLPLLDRKRLREAKREIELRATNWGNNKPAVGSSEAAMVESCSTVQPPASGKRTLESDEEAAALAKRHCASSPQSPEVDESYFKTRYRPWKEVYRDRFVVGMNWKHKRCSIKVFKGHRDSVMCLQFEDNILMTGSYDATVKIWDTDTGEELRTLKGHVAGVRCLQFDDTKLITGSLDRSIRVWNWRTGECISKYNGHAEAVIALHFDCTLLASASVDRTVKIWNFKDKSTFVLPHPQGVNAVKIDSVSRTVLTACDDGAARLWDLDTKTCIRVFHNHIGAVQQVIALPREIELENHLADCENDHVGTSSQGGDNILSTLSPLLEATSPSHPNSPFGSSFDQDQDRIESPRYILTSGVDTTIRLWETSTGRCLRTFFGHLEGIWALSADTLRIASGGMDRMVKIWDPRIPTGQDTYEGHSAAVNCIGLSDSRFITGGDDYQVRMYDFRA
What is the function of this protein?
Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
What are the official names of this protein?
Probable E3 ubiquitin ligase complex SCF subunit sconB, Sulfur controller B, Sulfur metabolite repression control protein B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MET30/SCONB/SCON-2 family.
Protein: DYR1_ECOLX
Sequence: MKLSLMVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRSSFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGDVYFPEIPSNFRPVFTQDFASNINYSYQIWQKG
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase type 1, Dihydrofolate reductase type I, Trimethoprim resistance protein.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: KUP2_ALBFT
Sequence: MSRTSNRESLAALTLGAMGVVYGDIGTSPLYTMKEVFSPATGVPLDGVHLIGAVSVIFWGLMMVVTLKYVLLILRADNRGEGGIMALTALAANAAGKTARRRTVLLLMGVFGAALFYGDSVITPAISVLSAVEGLEVVTPAFKSYVLPISVTVLIGLFAVQRFGTSLVGKLFGPVIMLWFAVLSVTGVAEIIQQPAILAALNPLNAFEFLRSQGWHMFVAVGAIVLAFTGVEALYADMGHFGKRPIQLAWLGLVLPALAINYMGQGALLMRDPSALANPFYRLFPQAWLMPAVVLATLATVIASQAVISGAYSMTKQAVLLGLLPRMQVQYTSAKEIGQIYMPEVNWLLLISVLLAVVGFGSSSALASAYGIAVTMTMLITTALTFFVVRDGWGYPLPVALAATAVFLALDTLLVVSCSLKFFQGGWFPLVLGLVIFTVMATWRRGRELLIDNIRHDDPELLPFITALSADVVHRVPRTAVYTVANPDTVPQALMHNLKHNQVLHERNVILTVVFHDVPWIAFDERVQVKPLVPGFWKVQVNYGFKNAPDIPRALELCQSQGLSINLFETSYFLSREIVVPTKGAGMAHWREALFAIMSRNAGSVADFFRLPNNCVIELGTRVQI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 2.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CYB_MACPR
Sequence: MTNIRKSHPLLKILNHSFVDLPAPSNISSWWNFGSLLGMCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYVHANGASLFFICLFIHAGRGIYYGSYLYSETWNIGVVLLFITMATAFVGYVLPWGQMSFWGATVITNLLSAIPYVGSTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMVHLLFLHETGSNNPLGLISDSDKIPFHPYYTIKDLLGMLLTILLLTGLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVVALVMSILILAIMPLLHTSKHRSLMFRPISQCLFWILVADMLTLTWIGGQPVEDPFITIGQVASILYFLLILVLMPIAGLIENHLIKL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS5_EHRRW
Sequence: MDVVKKSRNTHGSNDFSELIVSVRRVAKVVKGGRRFSFSVLVVIGDEKGKVGCGIGKHLEVSEAKVKAVNAARKNMIRVHLRESRTLHHDIQAKFCSSKVMLRSAKVGTGIIAGGSIRLIFEVLGVQDVVAKSIGSSNPHNVVYAVFTAFRKMLSPKQVASKRSRKIGEIIENR
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: TECRL_HUMAN
Sequence: MFKRHKSLASERKRALLSQRATRFILKDDMRNFHFLSKLVLSAGPLRPTPAVKHSKTTHFEIEIFDAQTRKQICILDKVTQSSTIHDVKQKFHKACPKWYPSRVGLQLECGGPFLKDYITIQSIAASSIVTLYATDLGQQVSWTTVFLAEYTGPLLIYLLFYLRIPCIYDGKESARRLRHPVVHLACFCHCIHYIRYLLETLFVHKVSAGHTPLKNLIMSCAFYWGFTSWIAYYINHPLYTPPSFGNRQITVSAINFLICEAGNHFINVMLSHPNHTGNNACFPSPNYNPFTWMFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTLLMSIQMSLWAQKKHKIYLRKFNSYIHRKSAMIPFIL
What are the official names of this protein?
Trans-2,3-enoyl-CoA reductase-like, Steroid 5-alpha-reductase 2-like 2 protein.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Protein: OEP80_ORYSJ
Sequence: MGTRRDVRFVSSGVKLPCADAAPAPAPAPTLLSAALPFARIGRAIDGVVRHVARSLPRLPVARAETGAGAAAAPIALPRRQKDGGGGGGGEERVLISEVAVRGKDGEPLERPELEAAAAAALRACRPNAALTVREVQEDVHRVVESGLFRSCMPVAVDTRDGIRLVFEVEPNQDFHGLVCEGANMLPSKFLEDAFHDRHGKIINIRHLDQVIKSVNGWYQERGLTGLVSYAEILSGGILRLQVSEAEVNNINIRFLDRRTGEPTVGKTQPETILRHLTTKKGQAYNRAQVKRDVETILTMGIMEDVTIIPQPVGDSNKVDLVMNLVERPSGGFSAGGGISSGITNGPLSGLIGSFAYSHRNVFGRNKKLNLSLERGQIDSIFRLNYTDPWIDGDNKRTSRTIMVQNSRTPGTLIHGGDHPDHGPITIGRVTAGIEYSRPFRPKWSGTLGLIFQHAGARDDKGNPIIRDFYNSQLTASGNAYDDTLLAKLESVYTDSGDRSSTMFVFNIEQGLPILPEWLSFNRVTARLRQGYEIGPARLLLSASGGHVEGNFSPHEAFAIGGTNSVRGYEEGAVGSGRSYAVGSGEVSCRMFGPLEGVVFGDYGSDLSSGPKVPGDPAGARGKPGSGYGYGVGVRVDSPLGPLRLEYAFNDKQARRFHFGVGYRN
What are the official names of this protein?
Outer envelope protein 80, chloroplastic, Chloroplastic outer envelope protein of 80 kDa, OsOEP80.
What is the protein family that this protein belongs to?
Belongs to the OEP80 (TC 1.B.33.2) family.
What are the subcellular locations of this protein?
Plastid, chloroplast outer membrane.
Protein: GOPC_PONAB
Sequence: MAAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSVDSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKEDEALRGHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVDGVNLRDTKHKEAVTVLSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDPSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
What is the function of this protein?
Plays a role in intracellular protein trafficking and degradation (By similarity).  May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity).  May also regulate the intracellular trafficking of the ADR1B receptor (By similarity).  May play a role in autophagy (By similarity).  Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (By similarity).  Overexpression results in CFTR intracellular retention and degradation in the lysosomes (By similarity).
What are the official names of this protein?
Golgi-associated PDZ and coiled-coil motif-containing protein, CFTR-associated ligand, PDZ protein interacting specifically with TC10, PIST.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Synapse. Postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides (By similarity).
Protein: SSB_VIBPA
Sequence: MASRGINKVILVGNLGNDPEIRYMPNGGAVANITIATSESWRDKATGEQREKTEWHRVVLFGKLAEVAGEYLRKGSQVYVEGQLQTRKWQDQSGQDRYSTEVVVQGFNGVMQMLGGRAQGGAPAMGGQQQQQGGWGQPQQPAQQQYNAPQQQQQAPQQPQQQYNEPPMDFDDDIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.