PharMolix/UniProtQA huggingface dataset:
Protein: CLPB_PROMP
Sequence: MKFVPSEFSNSAWDIFILSKEIAQNNFQQNIDSENILLALIKQDLLTSKILKKNCVNIRKIETKLTSLLDAKAKMKNKQKTLFIGETTEKVFLKANDLRVSFNDVVISTEHILYGLSYDEICSELVLNTKKIPEFLELLNKMKSESTINDNFESSNETLDKFGIDLTKSARDGILDPVIGRDEEIRRTIQILSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGDVPSSLNNRQLISIDMGSLIAGAKYRGEFEERIKNVLKKVKSSEGKIILFIDEIHTVVGAGATGGSLDASNLLKPMLARGELRCIGATTINEHKQNIEKDPALERRFQKIKINAPSVDDTISILRGLREKYEVHHSVRISDNALVAAASLSERYINDRFLPDKAIDLIDEAASRLNMIITSKPEEIDEIDRKVLQLEMENLSLQRESDNFSLERLKRINNELHDLKIRQSELNHQWQKEKEEIDEISNLKEEIESTQLKIEQAKRSFDLNKAAELEFGTLISLQKKLKIKSENLVDSFKSGEKNLLRQEVNFDDIAEVVSKWTSIPVNNLNQSEKEKLLKLELTLKEKIIGQNNAICAVSDSIKRSRTGLNDPNRPIASFLFLGPTGVGKTELSKVIAKTIFDSNSSITRLDMSEYMEKHSVSKIIGAPPGYLGFESGGQLTEAVRKNPYSLILLDEIEKAHKDVLDVLLQVLDDGIITDGQGRTISFKNSIIVLTSNLGSQSINDLSIRNEDKNEIKNIVNVELKKFFKPEFLNRLDEIIIFQNLELNELKDIAKLQLKKLENRLIKKDLNFQITDEAIDHLVKNSFDNSYGARPLKRIIQKEIETKIANNILNNNYLNKKEVYISIKDGCIFVN
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDN_MYCTO
Sequence: MPKSPPRFLNSPLSDFFIKWMSRINTWMYRRNDGEGLGGTFQKIPVALLTTTGRKTGQPRVNPLYFLRDGGRVIVAASKGGAEKNPMWYLNLKANPKVQVQIKKEVLDLTARDATDEERAEYWPQLVTMYPSYQDYQSWTDRTIPIVVCEP
What is the function of this protein?
Is involved in the bioreductive activation of bicyclic 4-nitroimidazole prodrugs such as PA-824 and delamanid developed for anti-tuberculosis therapy against both replicating and persistent bacteria.  It converts PA-824 into three primary metabolites resulting from reduction of the imidazole ring at C-3; the major one is the corresponding des-nitroimidazole that generates lethal reactive nitrogen species, including nitric oxide (NO), which appears to be responsible for the anaerobic killing activity.  Ddn uses the reduced F420 produced by FGD1 to activate PA-824.  Delamanid (OPC-67683) is also reduced by Ddn to its des-nitro form.
What are the official names of this protein?
Deazaflavin-dependent nitroreductase, F420H(2)-dependent quinone reductase Ddn, Fqr.
What is the protein family that this protein belongs to?
Belongs to the F420H(2)-dependent quinone reductase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: QUEE_THEAC
Sequence: MLITEIFHSIQGEGPYAGLPMLFVRTNVCNIRCEWCDTKYSFYGGKEIPLSELLGIVKEAKEGWVCFTGGEPLVQRDALAFVKSVVDMGKNVLIETNGTISIRNFVFSDRIFIDMDVKPPSAKVTKGFLMDNLRYLRKQDYLKIVIKDDTDLDFAIDFVDRYGEGLSFVFQPAWGSDIRRIADRIVGTGYNVRVLPQIHKIIYGDVPGV
What is the function of this protein?
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
What are the official names of this protein?
7-carboxy-7-deazaguanine synthase, CDG synthase, Archaeosine biosynthesis protein QueE.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
Protein: CYSG_SALTI
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLEAGARLTVNALTFIPQFTVWVNEGMLTLVEGPFDETLLDSCWLAIAATDDDTVNQRVSEAAESRRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPQHLGQVARYAGQLRARVKKQFATMGERRRFWEKFFVNDRLAQSLANADEKAVNATTEHLFSEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADIVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCHAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLVTGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQEKLIAFGMEANMPVALVENGTSVKQRVVHGVLTQLGELAQQVESPALIIVGRVVALRDKLNWFSNH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: MED21_ASPNC
Sequence: MADILTQLQTCLDQLATQFYATLCYLTTYHDNIPATPPPTSTTPSAAPLLAKIPKNASTPPVPASAPQAAQSQSQASPPPPDTANPQTGGQHADQQQQSPDGEGLPAPDSPATFAARQRELARDLVIKEQQIEYLISVLPGIDSSEAEQERRIRELEGELRIVEGVREERRRELGVLRRRLEGVLGVVERGIYSRD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL26_HUMAN
Sequence: MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEETIEKMQE
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:26100019, PubMed:23636399, PubMed:32669547).  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:26100019, PubMed:23636399, PubMed:32669547).
What are the official names of this protein?
60S ribosomal protein L26, Large ribosomal subunit protein uL24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSH_CHLL2
Sequence: MSIPDDLRYTKDHEWIKLLEDGSAALVGITDFAQSELGDIVFVELKPAGTKLKAHEVFGTVEAVKTVADLFAPVAGEIMEVNGSLDAAEVVNQDPYGEGWLVKIRIDDPASLAELLDAAAYRELIGE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: CYB_LIPVE
Sequence: MTNIRKTHPLMKILNKTFIDLPTPSNISSWWNFGSLLGLCLTVQILTGLFLAMHYTPDTSTAFSSITHICRDVNYGWMIRHLHANGASMFFICLYIHIGRGLYYGSYLFKKTWNIGVLLLFTTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWVWGGFSVDKATLTRFFALHFILPFIIVALTTVHLLFLHETGSNNPMGIPSNMDKIPFHPYHTIKDILGALLLMFVLLTLTLLAPDLLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLFSILILLFIPLLHTSKQRSMMFRPLSQLLFWLLMTDLLVLTWIGGQPVEHPYIIMGQLASILYFLLILVMMPTASFIENKILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TX90C_PHONI
Sequence: MKCAVLFLSVIALVHIFVVEAEEEPDSDALVPQERACLARGETCKDDCECCDCDNQCYCPFDWFGGKWHPVGCSCAHANQYFCDHKKEKCKKA
What is the function of this protein?
Probable neurotoxin.
What are the official names of this protein?
U11-ctenitoxin-Pn1a, U11-CNTX-Pn1a, Neurotoxin Pn3-6A.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 09 (Tx3-6) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PER4_DAUCA
Sequence: ANLFTSDQDLYTDSR
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 4.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Protein: VGE3_EHV2
Sequence: MATEVQFACALVVLLGCGYAGTPTPSKSTLIYNSQNCTTYPSIENGQSSLYYNGSWFIRYEFNCSSGYELQGWPYTTCIFWPKNGTIWTNGPPSCVKLNITTTLMPTSTSTTPVTTGTFPDPQNTTHPTHHTVKPTRRPINLLRFGYTPWAIITLVVIILLVVWIVNCCMGPMF
What are the official names of this protein?
SUSHI domain-containing protein E3.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: DNAJ_ECO7I
Sequence: MAKQDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNEKQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_LEPIC
Sequence: MVLLAAKGLSLLDVNPGLVVWTLVTFLVVVLVLKKFAWDVILKALDERAETVQNDIKKASELRLEAEALLKDYEARLNSAKDEANAIVAEAKSDALKLKNKLLEETNGEVKAQKDQAVKEIELAKAKALGQLQAQIVEMTITVAAKVLEKQLKSEDYKAFIETELDKLGKLSA
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TRHO_ALISL
Sequence: MSQYIVCALYKFVSLEDYTEIRQPLTQVMEDNQIRGTLLLASEGINGTVAGSRKAIDTLLTWFKEDSRLADVVYKESINDVQPFNRTKVKLKKEIVTMGVEGIDPLHVVGTYVKPADWNALISDPDVLLVDTRNDYEVDIGTFKYAVNPKTETFRDFPQYVAENLDPAKHKKVAMFCTGGIRCEKSTAYMKEQGFDEVYHLEGGILKYLEEVPEENSLWEGDCYVFDGRVAVNHQLEKSHYDVCNACRLPITDEDKQSDSFEKGVSCPKCIDQHTEEQKSRFREREKQVQLANERGETHVGGDAAKLIEQRKQEKKEKKQQQRSSK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: B2MG_SAGIM
Sequence: MARFVVVALLVQLSLFGLEAIQHPPKIQVYSRYPADNGKPNFLNCYVSGFHPSDIEVDLLKNGKKIEKVEHSDLSFSKDWSFYLLYYTEFTPNEKDEYACRVSHVTFSTPKTVKWDRNM
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system (By similarity).
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HTPG_HAEIG
Sequence: MSQNQETRGFQSEVKQLLQLMIHSLYSNKEIFLRELISNASDAADKLRFKALSNPALYEGDGDLRVRVSFDADKGIITISDNGIGMTREQVIDHLGTIAKSGTKEFLTALGQDQAKNSQLIGQFGVGFYSAFIVADKVTVKTRAAGEEADKAVLWESAGEGEYSVADIEKKSRGTDVILHLREDEKEFLNEWRLREIIGKYSDHIGLPVEMLTKEYDDEGKECGEKWEKINKSDALWTRSKNDVSDEEYKAFYKHLSHDFSDPVTWAHNKVEGNQAYTSLLYVPAKAPWDLFNREHKHGLKLYVQRVFIMDDAEQFMPNYLRFMRGLIDSNDLPLNVSREILQDNKITAALRKALTKRSLQMLEKLAKDDAEKYLQFWKEFGLVLKEGPAEDFANKETIAKLLRFASTHNDGCEQTVSLEDYILRMKEGQKAIYYITADSYVAAKNSPHLELFNKKGIEVLLLSDRIDEWMLSYLTEFDGKQLQSITKADLDLGDLADKESETQKQRDEAFGSFIERVKNLLGERVKTVRLTHNLTDTPAVVSTDNDQMTTQMAKLFAAAGQPVPEVKYTFELNPEHHLVKKVADIADEIEFADWVELLLEQAMLAERGSLENPAAFIKRINKLLG
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDB_CLOPS
Sequence: MGLKIIYGRAGTGKSTFCINQIKKKINNSPTNKLILLVPEQFTFQTENKVLNAIGERYVLNAEVLSFKRLAHNVFNECGGATRTIMGDAGKSMLIFKVLEDLGDNMTVFKNASRQKGFIDIASKTITEFKKYNVNNEVLDLTINEIEDENLKMKMEELKDVFNEFNSRLHEGYVDEEDQLLLLNEKLDGCSLYDGAEIWIDEFSSFTPNQLSVIGKLLKKAKSVNITLSIDEVNSPKVESDLFVATKNTEKRLMNLIQEEGIAFNGYINLNEDIPYRFKENKELAHIERQLYAYPFKQYRGENNSLRLYRANNNYDEIEFVAKDILRLVREKQYRFKDISVICREVDNYEKVISAIFAEYEIPYYIDKKIDIASNPLIVFINSAVDIISKNWTYESMFKYLKTGLIKEFRGIEGAELIDELENYVLAYGIKGKKWMEEWVNYSSSILKEEEISEENKQRLERLNDIRETIVTPLDEFNKECKGKKTLKEFAIILYEFLDSKLNIMDTIDKYVEYFKENDMAIEAKEYSEVRDIFIDVLEQAVDVLGNEVMDLDEFMKVLNIGLSQYEMGLIPVALDQVNIGDITRIKSRGTKALYIIGVNDGVLPSASKEEGILSDNDREILLEKGISLASDTRTKIFEEQFLVYTAFTIAEEYLVVTYPLADFEGKSQRPSIIVHRLKKILPNVKEESEGFKLVNDKYDKISAKIPTLNELMIAIRKNYDGAEIDDYWKYVYDWYLREPKWKERIEYVRKGLEYTNLENNISKEKAKKLYEDNKNKISLSVSRLERYAQCPFAYYIQYGLKAKDRKIYEFTAPDLGSFMHEILDEFTNEIKEKDLKWSDLSKENCKNIINSLVDNQVKNNKSSILNSSKRYSYFTDRFKRILTKSVMVISEQMKRSDFEIYKNELAFGFSKDVNSIKLDLPSGESFYLNGRIDRIDKLNLDGETYLRIIDYKTGSKKFDLNKFYNGLQMQLLVYLDALINNSENIVENQAMPGAILYFRIDDPILKSKGDLTEEEIKSEILKELKLEGLLLDDVKVVKAMDNTLEPGTHSLIIPANMKKAGDLGKNKALITMEQFELLRKYVNEKMVEICQNMIEGKIDIEPCKENKNIVCDYCNYSHICQFDSSLEDNRYKVIPKKKDEDIWKSINEKVGGEVNGD
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: YL39_SCHPO
Sequence: MAGLLNLCYIKDECQFSLLPLTYSFIKMDIDPYSVLGVEKDASDELIRRAYRKKALQHHPDRIHDEEKKVEARIEFDKVAIAYGVLSDKKRRKHYDKTGQLRETDADIDFDWKEWLDELYQGVVSGETLNEFKASYQYSEEEKCDVLKAYEKGKGSMDVILEEVMCCEISDEDRFRQVINNAIKDGKISKYKRFAPNEKKRKRRAKAAEREAQEAEELSMELGLDENLKKRRKAGASDEEALSALIRSRQKSRMYNLISNLESKYSKSSTKPKKSKKSRSKE
What are the official names of this protein?
Uncharacterized J domain-containing protein C1071.09c.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
Protein: ASIA_BPT4
Sequence: MNKNIDTVREIITVASILIKFSREDIVENRANFIAFLNEIGVTHEGRKLNQNSFRKIVSELTQEDKKTLIDEFNEGFEGVYRYLEMYTNK
What is the function of this protein?
Transcriptional inhibitor.  Inhibits sigma 70-directed transcription by weakening its interaction with the core of the host's RNA polymerase.  This allows Gp55 to successfully compete for the core enzyme.  Plays an important role during the prereplicative period of phage T4 development.
What are the official names of this protein?
10 kDa anti-sigma factor, 10 kDa RNA polymerase-associated protein, Audrey Stevens' inhibitor.
Protein: RS2_COPPD
Sequence: MAVVTLKQLLEAGVHFGHQTRRWNPKMKPFIYAERNGIYIIDLQKTYEQLEAAYSFVRDASKEGKTVLFVGTKRQAQEPIREEAERAGMPYVNQRWIGGFLTNFRTIRTRIKKYKELLALREQGYIESLDYKEQKRVMRELEKLDKYYSGVKDMDTLPDILFVVDTKKEEAAIREAKKIGIPVVAMIDTNCDPDLVDYPIPANDDAVRAIKLITSKIADAILEGREGRQGIVSSEGQQASMEEIAEELEAIDETEKYLDLIDEEKEEE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: GAG_HV1JR
Sequence: MGARASVLSGGELDRWEKIRLRPGGKKKYRLKHIVWASRELERFAVNPGLLESSEGCRQILGQLQPSLKTGSEELTSLYNTVATLYCVHQRIEIKDTKEALEKIEEEQTKSMKKAQQAAADTGNSSQVSQNYPIVQNLQGQMVHQAISPRTLNAWVKVIEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPVSILDIRQGPKEPFRDYVDRFYKTLRAEQATQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPGHKARVLAEAMSQVTNPATIMMQRGNFRNQRKNVKCFNCGKEGHIARNCRAPRKKGCWKCGKEGHQMKECTERQANFLGKIWPSYKGRPGNFLQSRPEPTAPPEESFRFGEETATPSQKQEQKQEPIDKELYPLTSLRSLFGNDPSSQ
What is the function of this protein?
Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.
Protein: OGRK_ECOLI
Sequence: MFHCPLCQHAAHARTSRYITDTTKERYHQCQNVNCSATFITYESVQRYIVKPGEVHVVRPHPLPSGQQIMWM
What is the function of this protein?
Cryptic version of the phage P2 OGR protein which acts as an activator of P2 late transcription.
What are the official names of this protein?
Prophage late control protein OgrK, Prophage P2 OGR protein.
Protein: RL5_MALP2
Sequence: MAIKSVLYDKYKKDVTKSLMKEFNYKSTMEIPRLEKIVINSGLGDATSDSKIVEIGLKELHLITGQKPIATKSKKSIATFKLREGQAIGAKVTLRRENMWNFLTKLISIAIPRIRDFRGLSTKSFDGNGNYTFGIKEQIIFPEIVYDDVKKLRGFDITIVTSAKTDKEAMFLLKELGMPFVKTKEAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: THIG_AGRRK
Sequence: MLALYGTEVASRLLLGTARYPSPAILAEAVRQSATEIVTVSLRRETAGGRNGGAFFEMIRTLGVRILPNTAGCHGVSEAVLTAKMAREVFQTNWIKLEVIGNHDTLQPDVFGLVEAARILASEGFEVFPYTTDDLVVAERLLDAGCKVLMPWCAPIGSAAGPLNLSALRAMRAHFPDVPLIVDAGIGRPSHATTVMELGFDAVLLNTAVAGARDPAAMAGAFAKAIDAGRLAFTAGMLEPRDMAVPSTPVIGKAVFA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKT4_WALAE
Sequence: MSSGCLLLLLGLLTLWAELTPISGLGGPKYCHLPADPGPCSNYRPAYYYNPASRKCEEFMYGGCKGNKNNFKTRHECHRVCVR
What is the function of this protein?
Snake venom serine protease inhibitor.
What are the official names of this protein?
Protease inhibitor 4, Kunitz inhibitor IV.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: IL1FA_HUMAN
Sequence: MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW
What is the function of this protein?
Cytokine with immunomodulatory activity.  Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans.  Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells.  Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS).  Ligand for IL-36R/IL1RL2.
What are the official names of this protein?
Interleukin-1 family member 10, IL-1F10, Family of interleukin 1-theta, FIL1 theta, Interleukin-1 HY2, IL-1HY2, Interleukin-1 theta, IL-1 theta, Interleukin-38, IL-38.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: RNKA_DANRE
Sequence: MVSLLFCGPKLAACGLVLSIWGVIMLALLGIFFTTHSAILIEDVPLTEEDLHSQDTPPQSVYKLYNQVGYNCFIAAVIYVGIGFLSFCQVRLNKRKEYLVH
What is the function of this protein?
Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds.
What are the official names of this protein?
Ribonuclease kappa-A, RNase K-A, RNase kappa-A.
What is the protein family that this protein belongs to?
Belongs to the RNase K family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ZYG11_XENLA
Sequence: MEESSPKSLLDITLLYLSTHLEKFCWERQDGTYCLQDAAIFPQEVADRLLQAMAVQRQLNEVTVGIFRGNQLRLKRACIRKAKISAVAFRKAFCHHKLIELDATGVNADITITDIISGLSSSKWIRENLQCLVLNSLTLSLEDPYERCFSQLSGLRVLSITNVLFYNEDLADVASLPRLESLDISNTSVTDITALVACKDILKSLTMHHLKCLKMTTTQILEVIRELKKLNHLDMSDDKQFTSDIACRLLEQNDILLHLVSLDISGRKHVTDKAVEAFIRHRPQMQFVGLLATEAGYSEFLSGEGCVKVSGEANQTQIAEALRRYSERSFFVREALFHLFSLTHVMDKANPEMLKLVVIGMRNHPTNLPVQLAASACVFNLTKQDLAAGMPVKLLADVTHLLLEAMKHFPNHQQLQKNCLLSLCSDRILQDVPFNRFDAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLSTEQTAQLGAELFIVRQLLQIVRQKTSQNMVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMKVLETFPSESSIQQKVLGLLNNIAEVKELHTELMCKDFIDQISKLLHSVEVEVSYFAAGIIAHLVSRGEETWTLSSSMRETLLEQLHSAILSWPTPECEMVAYRSFNPFFPLLACFRTPGVQLWAVWAMQHVCSKNPVRYCSMLIEEGGLVRLHRIRDHMCADPDVLRITITILDNLDRHLKKHGNPPCQKPPFTK
What is the function of this protein?
Serves as substrate adapter subunit in an E3 ubiquitin ligase complex zyg11-cul2-elongin BC.  Targets substrates bearing N-terminal glycine degrons for proteasomal degradation.
What are the official names of this protein?
Protein zyg-11 homolog.
What is the protein family that this protein belongs to?
Belongs to the zyg-11 family.