Protein: EGL4_CAEEL
Sequence: MSSGSRPSSGGGGGGGGASGGAGGGAPGGGGGGIRGFFSKLRKPSDQPNGNQVQVGTRTFEAHELQKLIPQLEEAISRKDAQLRQQQTIVEGHIKRISELEGEVTTLQRECDKLRSVLEQKAQSAASPGGQPPSPSPRTDQLGNDLQQKAVLPADGVQRAKKIAVSAEPTNFENKPATLQHYNKTVGAKQMIRDAVQKNDFLKQLAKEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGELQVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGETEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLKKDYGDKERLAQVVREPPSPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKAKTFALKALKKKHIVDTRQQEHIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDNDVPPDEFSGWDEGF
What is the function of this protein?
Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor (PubMed:18832350).  Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2 (PubMed:21573134).  Represses body size and lifespan through the dbl-1 and insulin pathways, respectively (PubMed:12571101, PubMed:15330854, PubMed:26434723).  May also signal through daf-3 and/or daf-5.  Role in egg-laying, dauer formation and motility (PubMed:12571101, PubMed:11181837, PubMed:21573134).  Regulates behavioral responses to various chemosensory stimuli in sensory neurons (PubMed:10978280, PubMed:22319638, PubMed:23874221, PubMed:26434723).  Required for the initiation of long term adaptation to prolonged odor exposure which results in a decrease in odor seeking behavior (PubMed:12495623, PubMed:20220099, PubMed:26434723).  May regulate this process by phosphorylating tax-2, a subunit of cyclic nucleotide-gated channel tax-2/tax-4 (PubMed:12495623).  In ASH sensory neurons, negatively regulates avoidance behavior to some bitter tastants, such as quinine, probably by phosphorylating rgs-2 and rgs-3 which are 2 regulator of G-protein signaling proteins (PubMed:23874221).  In AWB sensory neurons, involved in avoidance behavior to some repellent odors (PubMed:23954825).  In ASE left (ASEL) sensory neuron, involved in the sensing of environmental alkalinity downstream of receptor-type guanylate cyclase gcy-14 (PubMed:23664973).  In sensory neurons, involved in the signaling pathway downstream of insulin, TGF-beta and receptor-type guanylate cyclase responsible for inducing quiescence after food intake (PubMed:18316030).  Might play a role in aversive olfactory learning in AWC neurons when an odor is associated with food deprivation, depending on the ins-1/age-1 signal from the AIA to the AWC neurons (PubMed:27383131).  Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 in ALA neurons, involved in the decrease in locomotion during the quiescent state that precedes each larval molt (PubMed:17891142).
What are the official names of this protein?
cGMP-dependent protein kinase egl-4, Egg-laying defective protein 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=In resting AWC sensory neurons, localizes in cytoplasm (PubMed:20220099, PubMed:23954825, PubMed:27383131). Prolonged exposure to attractive odorants sensed by AWC neurons results in nuclear translocation (PubMed:20220099, PubMed:23954825, PubMed:27383131). Nuclear translocation is required for the adaptation to prolonged odor exposure and is controlled by G(o)-alpha subunit protein goa-1 (PubMed:23954825, PubMed:20220099, PubMed:27383131). Localization is regulated by cGMP levels: high cGMP levels result in cytoplasmic localization whereas low cGMP levels result in nuclear localization (PubMed:20220099, PubMed:22319638). Nuclear localization in AWC neurons is dependent on age-1 (PubMed:27383131). In addition, an intact sensory cilia structure is required for cytoplasmic localization in resting AWC neurons (PubMed:22319638). In resting AWB sensory neurons, constitutive nuclear localization is dependent on goa-1 (PubMed:23954825). In resting ASH sensory neurons, localizes in both cytoplasm and nucleus (PubMed:23874221). Cytoplasmic localization is important for negative regulation of quinine sensitivity in ASH neurons (PubMed:23874221).