PharMolix/UniProtQA huggingface dataset:
Protein: TA2R7_PANTR
Sequence: MADKVQTTLLFLAVGEFSVGILGNAFIGLVNCMDWVKKRKIASIDLILTSLAISRICLLCVILLDCFILVLYPDVYATGKEMRIIDFFWTLTNHLSIWFATCLSIYYXFRIANFFHPLFLWMKWRIDRVISWILLGCVVLSVFISLPATENLNADFRFCVKAKRKTNLTWSCRVNKTQHASTKLFLNLATLLPFCVCLMSFFLLILSLRRHIRRMQLSATGCRDPSTEAHVRALKAVISFLLLFIAYYLSFLVATSSYFMPETELAVIFGESIALIYPSSHSFILILGNNKLRHASLKVIWKVMSILKGRKFQQHKQIG
What is the function of this protein?
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.  Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 7, T2R7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS4_PYRHO
Sequence: MGDPKRQRKKYETPPHPWIKERLDRERVLMDKYELKNKKELWKHETQLKNFRRRARRLLAARGKQAEIEREQLLSRLKRLGLLPEDAVLDDVLSLTVEDILERRLQTIVYKKGLARTMRQARQLIVHGHIEVNGQIIRSPSYLVLKEEEDKITYARTSPFANPQHPERMMIEKAKQGGEA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RNAS7_HUMAN
Sequence: MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKHPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL
What is the function of this protein?
Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966).  Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966).  Causes loss of bacterial membrane integrity (PubMed:17150966).  Probably contributes to urinary tract sterility (PubMed:25075772).  Bactericidal activity is independent of RNase activity (PubMed:17150966).
What are the official names of this protein?
Ribonuclease 7, RNase 7, Skin-derived antimicrobial protein 2, SAP-2.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Note=Detected in urine.
Protein: PDRP_EHRCR
Sequence: MSTSVTLNLHLISDSTCETVASVARSALEHFRSVEVNEFVWSFINNNEQIDKIMSLIEKDKYNFIMYTMFDDELRRYLKQKAGAQEIPCIPVLSHVIREISCYLHIKKDPYISTNIGLDDEYFTRIDAINYTIAHDDGQNLWDIDQADIIILGVSRTSKSPTSIYLAYRGYRVVNIPLVHSINLSVDLSNMKNKLIVGLTIDIDRLIEIRRTRLVSMKNQNNYQYVDYEHVLMEIKETKRICVQNGWPIIDVTQKSVEEIAATIIQYFNKMQH
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative pyruvate, phosphate dikinase regulatory protein, PPDK regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
Protein: YVDE_VACCW
Sequence: MNIYCRYSSLTLANFLCLLMKLSISCPNSLELKYLDIFCWKVVNGRVTTLSYNIYPFLERSVINGICFTELDTNRVPILR
What are the official names of this protein?
Uncharacterized 9.3 kDa protein.
Protein: RS18_WOLSU
Sequence: MAEKKRYSKRYCKYTEAKIEFIDYKDVEMLKHSLSERYKIMPRRLTGNSKRWQERVEVAIKRARHMALIPYIIDRKKVVENPFKI
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: RASH_RAT
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
What is the function of this protein?
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
What are the official names of this protein?
GTPase HRas, H-Ras-1, Transforming protein p21, c-H-ras, p21ras.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus (By similarity). The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form.
Protein: RLMB_SHIFL
Sequence: MSEMIYGIHAVQALLERAPERFQEVFILKGREDKRLLPLIHALESQGVVIQLANRQYLDEKSDGAVHQGIIARVKPGRQYQENDLPDLIASLDQPFLLILDGVTDPHNLGACLRSADAAGVHAVIVPKDRSAQLNATAKKVACGAAESVPLIRVTNLARTMRMLQEENIWIVGTAGEADHTLYQSKMTGRLALVMGAEGEGMRRLTREHCDELISIPMAGSVSSLNVSVATGICLFEAVRQRS
What is the function of this protein?
Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
What are the official names of this protein?
23S rRNA (guanosine-2'-O-)-methyltransferase RlmB, 23S rRNA (guanosine2251 2'-O)-methyltransferase, 23S rRNA Gm2251 2'-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBX39_HUMAN
Sequence: MDEESELIQPQDQSCWAFLPDLCLCRVFWWLGDRDRSRAALVCRKWNQMMYSAELWRYRTITFSGRPSRVHASEVESAVWYVKKFGRYLEHLEVKFMNPYNAVLTKKFQVTMRGLLSCLSKSNNRLKSLSIQYLELDRLVWRNSIRSSFISSLSFFLKKMGKRLDYLNLKGARLTVEQGCQILDSLSYMRNENVISELNIEDYFSHHLAVYNSPQFKKTMSTFHNLVSLNLNYNCISDELLENLCENASTLRTINIKCHVHDPHGQVIWGMSWAKLARQATNLKVNFFFERIMKYERLARILLQEIPIRSISLRSCYFSDPDCSMRPTLIDLLPTFRHTLQKLTCEFNNNHESLDEELHLLIISCRKLFYFKIWAFLDVSFVERILKSQKERQCALRVFKARIYTNRYETNEEDKTLQEIYRKYRKLIESELSYFVIVYSVM
What is the function of this protein?
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
What are the official names of this protein?
F-box only protein 39.
Protein: ARGD_COREF
Sequence: MKNLATVEDTLTSWPQVLLNTYGTPPVELVTGKGSTVTDADGNVYIDLLAGIAVNALGHAHPAIIEAVTTQLSQLGHVSNLFATRPVVEVAAELVQRFALDDATIASQTQVFFCNSGAEANEAAFKLARLTGRHRILAATNGFHGRTMGSLALTGQPDKRIPFAPLPSGVEFYPYGDLDYLTTLVESDPTDTAAIILEPIQGETGVIPAPEGFLTGVRELCDKHGLLFIVDEVQTGIGRTGDFFAHQHEGVTPDVVTMAKGLGGGLPIGACLATGEAAKLFGPGKHGTTFGGNPVSAAAARAVLSVIDEEFCADVARKGELFAEQLRGVAGVADVRGRGLMLGVVLDQPVAKQAVTAGFKHGLILNAPADNIIRLTPPLVITDDEIRDAVRALAAVLAELNA
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHO2_BLAGS
Sequence: MSEQATSSGLESRSNGLRERNLQASKSAADRDVASQSLEDKLQVEEGEADTEKKTFGRTPDGTVFTVPPTRDMVSQLLSPSEPKNISDIFVLAILGCHILLLWFLPSSFRVAAFAVIFLFWRASYNIGIGWLLHMQSNGRTLVCWAKKSNIFVNPSTGQNPHPTLYKLLKWELETKISEQYSFEEAPTEYNTWLVFRRVVDLILMCDFTSYCLFAIACGGRPTGESFIMLALRWITGMSLVLFNLWVKLDAHRVVKDFAWYWGDFFYLIDQDLTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKILFISILAHAAQFAFLVLVENPHIEKTYNAPPPRKRVADTDTKPQEDENSHEGSVVSDTLSSAPVIPPLQPSSMHSLLGLHNIDLYRSTDQSVLLAQVLFFALTTLTPSTPVYQFCFVLNAALWRIWYSVGIGYILNRQSNCKMWTRHFVKYGESNHEAWRQWKGTYHLSMTMTYASFIAAAWKMYSFPQDWRYGLVLLRHILGASLIALQIWTSTSIYESLGEFGWFFGDFFFDEFPKLTYSGIYRFLNNPERVLGLAGVWGAVLITSTKSVVFLALLSHTLTLAFIQLVERPHMQKLYGQSLRRDAGLVRSLKRSLPPSLKQIHGSVDKILDDSFEFIEEFIEAARPKLAAGVQTFVKDTSALFQKYPARVTISRLEPDLAGYDLKDYSITLEGTQPSRPAQFERASDKEGERARSMPYRRGEQENLMFEYGAPIKVKWTAPLNHSKKDWVGLYMVTDNTSREVTRVSSQGRWIATNQASFDSETCEQGLISSDIVLKSSRDDGEPRDVASGEMVFSGDKLWWTQGVFEFRYHHNGKHNVMAVSRPFEICIGRFDEDDIEVDNYGLVRAAVEAALLPVVQNCFDRDPEIAPQTVEEHYGCLVDRDGKYSKRVVFAVHHMFGIEFAPEVVRADGNIRNLAWRICNAKKVLAPYSMSRSNGASTPTAAHEED
What is the function of this protein?
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
What are the official names of this protein?
Phosphatidylethanolamine N-methyltransferase, PE methyltransferase, PEAMT, PEMT.
What is the protein family that this protein belongs to?
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RHAM_RHIEC
Sequence: MTSEKHAFKMQLNPGMEAEYRKRHDEIWPELVDLLHKSGASDYSIHLDRETNTLFGVLTRPKDHTMASLPEHPVMKKWWAHMADIMATNPDNSPVQSDLVTLFHMP
What is the function of this protein?
Involved in the anomeric conversion of L-rhamnose.
What are the official names of this protein?
L-rhamnose mutarotase, Rhamnose 1-epimerase, Type-3 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the rhamnose mutarotase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF1_RHILO
Sequence: MFVTSAFAEETAPAVTGGDTHSGTGVPAEAHGTFPPFDPATFPSQLLWLAITFGLFYLFLKKVAMPRIGGIIDVRNDRISQDLDQASKLKGEADAAVAAYEQELAEAKKNASSIGQQAADAAKAEAETARKKIEAALDEKLGEAEARISSIKANAMKEVGSIAEDTASAIVEALVGGKASKAEIAAAVKSVAR
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b 1, ATP synthase F(0) sector subunit b 1, ATPase subunit I 1, F-type ATPase subunit b 1, F-ATPase subunit b 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: MAGBA_CANLF
Sequence: MPRGQKSKLRACKKRRQVREELQDLVGAQATAAVGEVFHSPSSLCFKSSPAAGSYSVSQGPQGAISTSTTAASVSHTRSNESADNQVEERPRSSQAQPTAEPFPRGPLDEKVVKLVHYLLYKYQMKELISKAGMLRNVIQMYRNHFHEILKRASEHLELVFGLDLKEVDPNRHIYVLVNKLELSYDAMLSDDEGVPKTGLLMTILGVIFTKGNCAAEEQVWQVLNVIGLYAGMEHFIFGEPRKLITEDLVKEEYLEYRQVANSDPPRYEFLWGPRAYAETSKMKVLEFLAKVHYTVPSAFPAWYEEALQDEEERAQARAAARAHTAAMASARARAMTSAHSKGITNEHSRAMTNVHSRAIASVRSKATQTIPPTPNKV
What are the official names of this protein?
Melanoma-associated antigen B10, MAGE-B10 antigen.
Protein: CLPB_TROW8
Sequence: MSESQSELDKYGTNLTKTAATNKLDPVIGRDAEIRRVCQILSRRTKNNPVLIGSAGVGKTAIVEGLAQRIVAGDVPESLRNKEIVSLDLSALLAGASYRGEFEKRVKNLLEEIQKSKVIIFIDEVHTLMSAGAAEGAIAAGNMLKPLLARGELRLIGATTLDEYREHLEKDPALERRFQQVFVGEPNLEDCIAIMRGLKERYEAHHKVSISDTALVTAVELSSRYITGRQLPDKAIDLLDEAASSLRMEIDSSPVELDQLRREVDRLRLEELALKSENDPTSEQRLRSITNQLSGKQEMLNTLQASWNSERARLNQIGALKEQIDIAKQSADIAQREGRLEDASRLLYATIPQLQKNLAEKLEEQDSAPLVSDQVMPEDIASVVEGWTGIPVKKLMQKDAKQLLHLEEDLSKSVIAQKVAIGVIADAVRRSRAGLSDPNRPSGTFLFLGPTGVGKTQLVKALASLLYDGEIVRIDMSEYSEKFSISRLIGAPPGYIGHESAGQLTESVRRRPYSVVLFDEAEKAHPEVFDILLQVLDEGRLTDSHGRTVDFRNTIIVLTSNIGSRYLSDISLEATTAHEYVNDEVRRTFRPEFLNRLDEIVIFEPLSQSDICQIVDLNIESLNKRIKDRRIVVTVSEDLRRWLSKSGYDVIYGARPLRRLIQREIEDRLAKLIIEGLIHDGQTASFDLSGGAVNAQVCS
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RP54_CLOK5
Sequence: MDFALNLTQEQRLAMTQEMQLSIKLLQMSSFELQEYVEKELQENPVLDIKESNVDKVEKDKLEYKEIIKNLDFDNYSHHSYDRNPDEEVSPFNFISEEKSLKEYLKDQIRDLDENQCIKTICLYIIENIDDRGYLILENEEIEEELKISKELAAYCVDLIHSLEPHGIGARNLAECLKIQIKQKDMDEENIFIMIDKYLEFIAENKYNVIAKELNIDVKQAQEYGDLIKTLSPKPSRGFYTGESVRYISPDAYIKKIDSEYFIIMNDDLTPRLTINAIYKDIINNDTDKDAVSYVKEKLNSALFLIKSIQHRKSTIYRVLEKIVEIQKDYFDYGESYLKPMTLKEIASSMDMHESTVSRAIRDKYIHINRGIVKIKDLFTTGMAASFSEENVSSLIIKNSIKKMIDNEDRKKPLSDQKICDLINEEGMNISRRTVAKYREEMGIKSSKGRKRF
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
What are the official names of this protein?
Putative RNA polymerase sigma-54 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: FOLD_STRS2
Sequence: MTVIDGKALGVKLQAALAEKTARLKEEKGLVPGLVVILVGENPASQVYVRNKERSALAAGFKSEVVRVPDTISESDLLDLIERYNQDDEWHGILVQLPLPAHISEEKVLLAIDPDKDVDGLHPTNMGKFWSGHPVMIPSTPAGIMEMFKEYQIELEGKSALVIGRSNIVGKPMAQLLLDADATVTIAHSRTKNLPDLARQADIVVVAIGRGHFVTKEFVKLGAVVIDVGMNRDENGKLIGDVKYDEVSEVASYITPVPGGVGPMTITMLMEQTYEACVRSAK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PIMT_PECAS
Sequence: MVNKRIETLLAQLRQQGIEDERLLTAIEAVPRERFVDEAFEHKAYENTALPIGSGQTISQPYMVAKMTELLNLTPESRVLEIGTGSGYQTAILAHLVQHVCSVERIKGLQWQAKRRLKQLDLHNVSTRHGDGWQGWASRGPFDAIIVTAAPPEIPQALLEQLDEGGVMVLPVGEQSQILQVVQRHAGEFIIKTVEAVRFVPLVKGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOP58_CRYNB
Sequence: MLVLTETSVGFVVFKLSSDAKIDNKDLWKEFETPEGANKALKVQAIQRFTSTASAVEDLTAVQDGRLTDSLSRFLLDTVGGADDGEKKKKKKKIEEMLVVSDPKLAGTINKALSIPVLSDSSTQDLYRGIRQQLASLLGGVDQKDLNTMSLGLGHSLSRFKLKFSTDKVDTMVIQAIALLDDLDKEINIYAMRVKEWYGWHFPEMAKIIVDNIAFARVVKAMGFRTNAVTTDFSLLLPEDLEATLKSAAELSMGTEISDSDMTHIHSLCDQVISISEYRTQLSEYLRNRMQAIAPNLTALVGELVGARLISHAGSLMNLAKHPASTVQILGAEKALFRALKTKHDTPKYGLIYHASLIGQAPQKLKGKMARMVATKAALSIRVDALSDADSRSDVSAAEVGISNRVKLESRLRALEHQAGIQSVRKVVSANGQQGRQQPRFEMSGVTGSYNAATDNVPLNGDLLPTQPATEEVKEEKDEKKDKKKKRKSEVAEAGDVTMDGDADLSMVAGETKEERRARKEAKKAAKAAKKAAEESGDGDKKSKKRRADEDEDSEKKKKKKKKDE
What is the function of this protein?
Required for pre-18S rRNA processing.  May bind microtubules (By similarity).
What are the official names of this protein?
Nucleolar protein 58.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: VP47_NPVAC
Sequence: MFVTRLEHTTQFLPQACKLEDEVLVLYAIYLNGFDYTLPRFVKREVQVNADGFVRFDYNIKMFDFARFTDMTQTTPEDIDDYINLTRINSLSDHDLKMLQLVCRDRWYKGDVARLRRILQQKDVDDLVKFVCNVMWERAYEDHYTLGQQLSIRITTKLIQSGLDFKHQPDTTAPVSVRGWEDATFEKYLQSITSISEVIKRHVFSKKYICLEVAASYWSDAVESLQQENFRIILNSKTPYVLLIEMDDDKNSMVYLRKLAHLLENKIVNLLFVTDVEFYFKNGNFMFYLYNSLKFYYYCLKNKFAFENVDKEIFFLLYTIVALEWFNGGHLNSFTLEKSALYNPLELSTRRLNSIKRAAQHNRVINCDSEINMDYIRGKRVRTGAHYGKRVVNFDLNQSLH
What is the function of this protein?
Component of the viral DNA-dependent RNA polymerase which is composed of four equimolar subunits of LEF-4, LEF-8, LEF-9, and p47.  Plays an essential role in late and very late gene expression.
What are the official names of this protein?
DNA-directed RNA polymerase subunit p47.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae p47 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ZORE_ECOLC
Sequence: MKLSIDISELIQLGKKMLPEGVDFFLDESPIDFDPIDIELSTGKEVSIEDLDPGSGLISYHGRQVLLYIRDHSGRYDAAIVDGEKGKRFHIAWCRTLDEMRHKNRFERYHATNRIDGLFEIDDGSGRSQDVDLRVCMNCLERLNYKGSIDKQRKREIFKSFSLNEFFSDYSTCFRHMPKGIYDKTNSGYVENWKEISKEIREKANYVCNDCGVNLSTAKNLCHVHHKNGIKYDNHHENLLVLCKDCHRKQPLHEGIFVTQAEMAIIQRLRSQQGLLKAESWNEIYDLTDPSVHGDINMMQHKGFQPPVPGLDLQNSEHEIIATVEAAWPGLKIAVNLTPAEVEGWRIYTVGELVKEIQTGAFTPAKL
What is the function of this protein?
Component of antiviral defense system Zorya type II, composed of ZorA, ZorB and ZorE.  Expression of Zorya type II in E. coli (strain MG1655) confers resistance to phages SECphi7 and T7.  While most T7 infected Zorya-containing cells undergo abortive infection, a minority produce viable phage progeny.  These eventually accumulate to a high multiplicity of infection, leading to culture collapse by 170 minutes after initial infection (PubMed:29371424).  ZorA and ZorB probably assemble in the cell inner membrane and exert their effect there.  This may be a nuclease (Probable).
What are the official names of this protein?
Zorya protein ZorE, Putative nuclease ZorE.
Protein: NANE_SHISS
Sequence: MSLLAQLDQKIAANGGLIVSCQPIPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLALVKTLSEAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: SSRP_WOLWR
Sequence: MEVIAENRKARFEYFILEEFEAGMVLLSSEVKSLRERKVNISDAYVVEKNSEVWLHNMHIAEYKAANRKNHKPKRERKLLLHKKEINKLIGQIKTAGITVVPLSVYFNDKGFAKTKIAIVKGKKLYDKRATIKQREWDREKSRLSKNNL
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RBPA_MYCTO
Sequence: MADRVLRGSRLGAVSYETDRNHDLAPRQIARYRTDNGEEFEVPFADDAEIPGTWLCRNGMEGTLIEGDLPEPKKVKPPRTHWDMLLERRSIEELEELLKERLELIRSRRRG
What is the function of this protein?
Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
What are the official names of this protein?
RNA polymerase-binding protein RbpA.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase-binding protein RbpA family.
Protein: OBGC1_ORYSJ
Sequence: MAPAVAVVAAAAAFPFRLFSAEARRNTKGSRSKRGSARPLKPSPPPRPSASSSAAGGGGATTFTRLPLRNAPASVEVTLDRFPTANPEPRASTFTRRNGERLGDDEEDEEEEEDEVELGLRGATTFARLPLRDSPDGGDLTIGHFDAGVAPQEGLRSRAISRQLVEHLDDVEEEEEEQVVSRLDIFEGAKGREARAFLPDEDDEDDDVVVFDPEYDGYSDDEEFVATAVEQSPRGDAIAVAELEKLKYDNDDDDDDDDEVVVFHPDDDEEVDVFEDYDDDEEEETKEKGVPAVMRCFDTAKIYAKAGDGGNGVVAFRREKYVPLGGPSGGDGGRGGNVFVEVDGDMNSLLPFRKSVHFRAGRGAHGQGRQQAGAKGDDVVVKVPPGTVVRSAAGDVELLELMRPGQRALLLPGGRGGRGNAAFKSGTNKAPRIAEKGEKGPEMWIDLELKLVADVGIVGAPNAGKSTLLTAISAAKPTIANYPFTTLLPNLGVVSLDFDATMVVADLPGLLEGAHRGYGLGHEFLRHSERCSVLVHVVDGSGEQPEYEFEAVRLELELFSPSLVDKPYIVVYNKMDLPEASERWNKFQEKLQAEGIEPYCISAMNRQGTEDVVLAAYKVLQKDRQRMKDDEEWNGPENLNHVADAIKRERRAPMNEFEIFHDKGTNTWNVVGAGIERFVQMTNWQYSESLKRFQHALEACGVNKTLIKRGVKEGDTVVVGEMEMVWTDEPSKTRSSKTMNSKDDSVRWPEFG
What is the function of this protein?
Probable GTP-binding protein that plays a crucial role in chloroplast development and is required for leaf greening during plant growth.
What are the official names of this protein?
Probable GTP-binding protein OBGC1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GFPT2_MOUSE
Sequence: MCGIFAYMNYRVPKTRKEIFETLIRGLQRLEYRGYDSAGVAIDGNNHEVKERHIHLVKKRGKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPNAVNSHPQRSDKDNEFVVIHNGIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSIHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPVLYPTCNIENVKNICKTRMKRLDSSTCLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSATDDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKDRGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLDEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE
What is the function of this protein?
Controls the flux of glucose into the hexosamine pathway.  Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2, D-fructose-6-phosphate amidotransferase 2, Glutamine:fructose-6-phosphate amidotransferase 2, GFAT 2, GFAT2, Hexosephosphate aminotransferase 2.
Protein: SDHE_HAEI8
Sequence: MEKYNKLRIEWDCRRGMLELDKIIMPFYLKHFDELTDDKKDIFIRLLASTDLQLFSWFFNRGKSSDSEIQSMVEYIQNVQKITTN
What is the function of this protein?
An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins.  Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
What are the official names of this protein?
FAD assembly factor SdhE.
What is the protein family that this protein belongs to?
Belongs to the SdhE FAD assembly factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_METS5
Sequence: MKIRIAARGSKLSLKQVEIVTTYLQAKGYETEFIEIKTKADLFGNKPLHEIGKGVFEKEVNEAVLQGRADIAVHSMKDMSSELPPGLELLATPKRENPVDVLVSELNLEELPEKSRIGTGSLRRANFLKVVRPDLVVENIRGNVDTRLRKYRDHEYDGIILAEAGLRRLGVEVKRFPLDVESFTPEPNQGIIAVVGSPKFLGLFQELNDTGTMKEALAEKETVKVVGGGCHSPLGVLFRLEDDVLHGIASYSNGVKRVTVKLSTRESPQIAGNQLGKALVKAMKDEGLIP
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Probable porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.