PharMolix/UniProtQA huggingface dataset:
Protein: PURA_HAES1
Sequence: MGKSVVVLGAQWGDEGKGKIVDLLTDRVKYVVRYQGGHNAGHTLIINGEKTVLRLIPSGILRENVTCLIGNGVVLSPTALMQEMGELESRGINVRERLLISEACPLILPYHVAMDKARESALGNKAIGTTGRGIGPAYEDKVARRGLRVGDLFDKELFAEKLKNILDYYNFQLVHYYKAEAVDYQKTLDEVFAVADIITAMVADVSTILDIARKKGDNILFEGAQGTMLDIDQGTYPYVTSSNTTAGGVSTGAGFGPRHIDYVLGIIKAYCTRVGGGPFTTELFDDVGAEIARKGNEFGAVTGRPRRCGWFDAVAIKRAIQTNSISGFCMTKLDVLDGFHEIKICVGYKMPNGEIAEYAPLAAKDWEGVEPIYETLPGWQENTFGITDVNQLPENTRNYIKRIEEVTGVPIAILSTGPDRVETMILNDPFAV
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHFL_XENTR
Sequence: MDGNVQEELELEKSIRRFREKFHGKVTLETAVALMRRFTNNHDQVCKYIILCMDNDTDLDVRNDLRNDPVARNVINKIKSDDQKAKEMPKDKDIKDLAKRMNTLPLTEKNLKMFNDAAENRIPSRDRQFACKECDFVWWRRVPQRKEVSRCHRCRKKFDPVPENKMWGIAEYHCPVCRRMFRGFGQIEVSSPCYVCRNPVLPSCILPPRRNQGPRTRNTHSCLAENCYNRRVPFVAGLQCAHPKSRIMNQLPKVLHPSEPHISTGSTIATCLSQGSLTENDIDDIILDDIKEEEEDEGSDDSDG
What is the function of this protein?
Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes.  Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site.  May exhibit antiviral activity.
What are the official names of this protein?
Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog, SHFL, Repressor of yield of DENV protein homolog.
What is the protein family that this protein belongs to?
Belongs to the SHFL family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly found in t for dsDNA.
Protein: ASSY_CITBB
Sequence: MAKKEVKKIVLAYSGGLDTSIILKWLKNEYGCEVVTFSADLGQGDELEPVREKAFKTGADKVYIDDLREEFVRDFVYPMFRANAIYEGSYLLGTSIARPLIAKRQMEIAKIEGCDAVSHGATGKGNDQVRFELAYYHFNPGITVVAPWREWKLNSRQALINYAKRNDIPIPITKKRPWSSDRNLLHISFEGGILEDTWLEPPENMFVLTKAPEKAPNKPQYIEIEFEKGNAVAVDGVRMSPAELLAHLNTIGGEHGIGRVDLLENRSVGMKSRGVYETPGGTILREAHMAVEQITMDREVMHLRDSLIPRYAEMIYNGYWFSPEREMMQCMIDESQKTVNGVARLKLYKGHCRTVGRKSESDSLFNLDFATFEKDQVYNQADAEGFIKLNSLRLRIRSLMLANKNK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COBS_ECOLC
Sequence: MSKLFWAMLSFITRLPVPRRWSQGLDFEHYSRGIITFPLIGLLLGAISGLVFMVLQAWCGVPLAALFSVLVLALMTGGFHLDGLADTCDGVFSARSRDCMLEIMRDSRLGTHGGLALIFVVLAKILVLSELALRGEPSLASLAAACAVSRGTAALLMYRHRYAREEGLGNVFIGKIDGRQTCVTLGLAAIFAAVLLPGMHGVAAMVVTMVAIFILGQLLKRTLGGQTGDTLGAAIELGELVFLLALL
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAK2_COLP3
Sequence: MGKIIGIDLGTTNSCVAVLDGDSVRVIENAEGDRTTPSIIGYTAEGETLVGQPAKRQSVTNPENTLYAIKRLIGRRFEDKETQRDIDIMPFGIVKADNGDAWVQVKGEKIAPPQVSAEVLKKMKKTAEDFLGETVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAYGMDKQEGDKVVAVYDLGGGTFDISIIEIDEMDGEHTFEVLATNGDTHLGGEDFDNRLINYLVAEFKKDQGMDLTSDPLAMQRLKEAAEKAKCELSSAQQTDVNLPYITADGSGPKHMNIKVTRAKLESLVEDMVKATLEPLKQALKDADLSVSKIDDVILVGGQSRMPLVQKTVTDFFGKEPRKDVNPDEAVASGAAIQAGVLSGDVTDVLLLDVTPLSLGIETMGGVMTKVIDKNTTIPTKQSQTFSTADDNQAAVTVHVCQGERKQASANKSLGQFNLEGIEPAQRGTPQIEVTFDIDADGILHVTAKDKNTGKEQKITIKASSGLSDEEVEQMVRDAEANADADAKFEELVTARNQADGMIHATRKQVEEAGEELPSEDKEKIEAALTELEEAVKGDDKEVIEAKTQALMEASAKLMEIAQAKEQAQSAPEGAQEADAAPADDVVDAEFEEVKDDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK 2, HSP70 2, Heat shock 70 kDa protein 2, Heat shock protein 70 2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: CYP5_CAEEL
Sequence: MKSLLVVAAVLAVGALAQGDDAKGPKVTDKVYFDMEIGGKPIGRIVIGLFGKTVPKTATNFIELAKKPKGEGYPGSKFHRVIADFMIQGGDFTRGDGTGGRSIYGEKFADENFKLKHYGAGWLSMANAGADTNGSQFFITTVKTPWLDGRHVVFGKILEGMDVVRKIEQTEKLPGDRPKQDVIIAASGHIAVDTPFSVEREAVV
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase 5, PPIase 5, Cyclophilin-5, Rotamase 5.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_ARTGW
Sequence: MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVNHICRDVNYGWLLRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLVMLTALATLVLFSPDLLGDPDNYIPANPLTTPPHIKPEWYFFFAYAILRSIPNKLGGVLALVVSILILAIVPILHMSKQRSMMFRPLSQCLFWLLVAVLFTLTWIGGQPVEHPYIIIGQTASALYFLIILFLMPMTSMVENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TCYN_BACSU
Sequence: MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFLRCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVMEGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDVLLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIVEQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI
What is the function of this protein?
Part of the ABC transporter complex TcyJKLMN involved in L-cystine import.  Responsible for energy coupling to the transport system (Probable).  Is also involved in cystathionine, djenkolate, and S-methylcysteine transport.
What are the official names of this protein?
L-cystine import ATP-binding protein TcyN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. L-cystine importer (TC 3.A.1.3.13) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DAPB_AJECN
Sequence: MATEKGHSRDDEERVPLTRGSTEFRNSIDSFDYSSSTASLSLAVIDRINNSTQDAGLSEKGPRDDDDDRYWDDDVEYDVEDADYIPSGGKPMHKSVKIALWSLLFLSLGGWSLAFVLFIFRSHDTYQTPILSEDNISSGGLRGDRITLDDVLGEEWMPRHHFISWFPGPNGEDGLLLEKDGPGSTGYLRVEDIVSRKDTNSSKGSIVLMQKNTFTVGGETVICSQVWPSPDLKTVLVLSEKKQNWRHSFTGKYWLFDVDTQTGQPLDPAAQDQRIQLASWSHKSDAVVFTRDNNMFLRKLSSKEVITITSDGGVDLLYGVPDWVYEEEVFSGNSATWWAHDGNYIAFLRTNESAVPEYPIQYFVSRPSGEDPNLGEENYPEVREIKYPKAGAPNPIVDLQFYDIRKGEIFSVDVADRFPDDNRLIIEVLWASNGKVLVRETNRESDILIIAAIDVLSRTGKIVRKEDINALDGGWVEPTQSTRFIPADPSNDRPEDGYIDTVIHEGRDQLAYFTPLDNPKPLILTKGHSEVVNSPSGVDLKRGLVYFVVAGNEPWERHVYSVKFDGTALQPVTNVSESSYYDVSFSDGAGYALLNFRGPKVPWQKVISTPANENPFEEIIEQNNHLSRKLRLFSLESKVFQYINIDGFSLPVLERRPPNFDPTKKYPVLFYLYGGPGSQTVDKKFGVDFQSYVASTLGYIVVTVDGRGTGYIGRKSLSLVRGKLGHYEARDQIEVAKKWAAKPYVDESRMAIWGWSYGGFMTLKTIEEDGGRTFQYGMAVAPVTDWRYYDSIYAERYMHTPQHNPQGYDSSAISNTTALANSVRFLVMHGTADDNVHIQNTLTLLDKLDLANVDNYDVHVFPDSNHNINYHNAHKMVYTRLADWLVNAFNGQWLKTNNPTPNDSLFRRVATWAGLYKFKHLC
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: RSMH_DEIDV
Sequence: MTLPEDTTTAESLIHTSVLSAEVLEALAPTPGKTIVDGTLGGAGHTRLLLEAGAHVYGIDQDPFALDRAREAGLPNLTVLQGNYRDMVSLLEQAGVSQVDGILLDIGVSSFQLDDAGRGFSYHTEAPLDMRMSQSGESAADVVNTYEEEDLAAIIYEYGEDRLSRRIARAIGQARQKAPIETTVQLAEIVKRAYPGFSKGIHPARRTFQALRIHVNDELGALRDGLQAAETLLRPGGRLAVISFHSLEDRIVKRFLLGSEVLQPLTKRPVVASDEEQAINPRSRSAKLRAAERVVVQEAS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL37A_OSTLU
Sequence: MAKRTKKVGIVGKYGTRYGASLRKVVKKQEVSQHSKFFCDFCGKYGMKRKAVGIWSCKGCNKTKAGGAYSLNTGGSVTVRSTIRRLREATEK
What are the official names of this protein?
60S ribosomal protein L37a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein: SCX1_BUTMA
Sequence: GVRDAYIADDKNCVYTCAKNSYCNTECTKNGAESGYCQWLGKYGNGCWCIKLPDKVPIRIPGRCRGR
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  Since the experiments have been done on F11 cells (immortalized cell line derived from rat DRG neurons mainly expressing Nav1. 3/SCN3A, but also Nav1. 7/SCN9A and Nav1. 2/SCN2A), it is supposed to act on these channels.  The slow of inactivation process is partially reversible.  Is lethal to mice.
What are the official names of this protein?
Alpha-toxin Bu1.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: C5AR1_MOUSE
Sequence: MDPIDNSSFEINYDHYGTMDPNIPADGIHLPKRQPGDVAALIIYSVVFLVGVPGNALVVWVTAFEARRAVNAIWFLNLAVADLLSCLALPVLFTTVLNHNYWYFDATACIVLPSLILLNMYASILLLATISADRFLLVFKPIWCQKVRGTGLAWMACGVAWVLALLLTIPSFVYREAYKDFYSEHTVCGINYGGGSFPKEKAVAILRLMVGFVLPLLTLNICYTFLLLRTWSRKATRSTKTLKVVMAVVICFFIFWLPYQVTGVMIAWLPPSSPTLKRVEKLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLLRSLPSIIRNALSEDSVGRDSKTFTPSTTDTSTRKSQAV
What is the function of this protein?
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.  The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events.  Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
What are the official names of this protein?
C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
Protein: Y138A_HAEIN
Sequence: MITVFGLKSKLAPRREKLAEVIYNSLHLGLDIPKGKHAIRFLCLEKEDFYYPFDRSDDYTVIEINLMAGRMEGTKKRLIKMLFSELEYKLGIRAHDVEITIKEQPAHCWGFRGMTGDEARDLDYDIYV
What are the official names of this protein?
Uncharacterized protein HI_1388.1.
Protein: PYRF_ERYLH
Sequence: MSNPVFLALDIPRLEAGKALVDKVKAHIGGVKLGMEFFYAHGHHGVHEIAHCGLPVFLDLKLHDIPNTVAAAMQSIHVLEPAIVTVHASGGRAMMEDAKAAAGENTKVVGVTMLTSLDERDLERTGVDGSPHDHVMRLAELAENAGLDGIVCSGQEVGAVHKQWKQGFFVVPGLRPAGSASGDQKRVVTPRQARDDGASVLVIGRPISKADDPEQAARDIEATL
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: YJBT_ECOLI
Sequence: MKRNLIKVVKMKPYFAALMLSVSVLPAYAGPLGTADKADLPQSNVSSPMMAQSLRQPDLQPISTDRKTECFRLYTPDRKPGVNCVPDGSTGH
What are the official names of this protein?
Uncharacterized protein YjbT.
What is the protein family that this protein belongs to?
Belongs to the YjbT family.
Protein: JUN_CHICK
Sequence: MSAKMEPTFYEDALNASFAPPESGGYGYNNAKVLKQSMTLNLSDAASSLKPHLRNKNADILTSPDVGLLKLASPELERLIIQSSNGLITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHNQNTLPSVTSAAQPVSGGMAPVSSMAGGGSFNTSLHSEPPVYANLSNFNPNALNSAPNYNANGMGYAPQHHINPQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
What is the function of this protein?
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.  May be involved in activated KRAS-mediated transcriptional activation of USP28.  May bind to the USP28 promoter.
What are the official names of this protein?
Transcription factor Jun, Proto-oncogene c-Jun, Transcription factor AP-1 subunit Jun.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Jun subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL34_STRZP
Sequence: MKRTYQPSKLRRARKHGFRNRMSTKNGRRVLAARRRKGRKVLAA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: ULBP3_HUMAN
Sequence: MAAAASPAILPRLAILPYLLFDWSGTGRADAHSLWYNFTIIHLPRHGQQWCEVQSQVDQKNFLSYDCGSDKVLSMGHLEEQLYATDAWGKQLEMLREVGQRLRLELADTELEDFTPSGPLTLQVRMSCECEADGYIRGSWQFSFDGRKFLLFDSNNRKWTVVHAGARRMKEKWEKDSGLTTFFKMVSMRDCKSWLRDFLMHRKKRLEPTAPPTMAPGLAQPKAIATTLSPWSFLIILCFILPGI
What is the function of this protein?
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
What are the official names of this protein?
UL16-binding protein 3, ALCAN-gamma, NKG2D ligand 3, N2DL-3, NKG2DL3, Retinoic acid early transcript 1N.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: SYGA_PROM5
Sequence: MFFQDIIQNLNKFWSEEGCLIMQPYDTEKGAGTMNPHTFLRAIGPEPWSVAYAEPCRRPTDGRFGDNPNRAQHYFQYQVIIKPSPDRIQEKYLSSLEFLGINPKEHDIRFVEDNWESPTLGAWGVGWEVWLDGMEVTQFTYFQQCGGVDCNPIPIEITYGLERIATFLQDKESIWDLDWNKDFNYSDIWLQFEKNQCEFNFRASNPENMRKLFSIYQEEAVSLLDKKLTFPALDFVLKCSHCFNLLDARGVISVTDRAQYIEKIRKLAREVASSWIIERESLKFPLLKK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C4BPB_RAT
Sequence: MLCLVVCCLIWLISALDGSCSEPPPVNNSVFVGKETEEQILGIYLCIKGYHLVGKKSLVFDPSKEWNSTLPECLLGHCPDPVLENGKINSSGPVNISGKIMFECNDGYILKGSNWSQCLEDHTWAPPLPICRSRDCEPPETPVHGYFEGETFTSGSVVTYYCEDGYHLVGTQKVQCSDGEWSPSYPTCESIQEPPKSAEQSALEKAILAFQESKDLCNATENFVRQLREGGITMEELKCSLEMKKTKLKSDILLNYHS
What is the function of this protein?
Controls the classical pathway of complement activation.  It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b.  It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a.  It interacts also with anticoagulant protein S and with serum amyloid P component.
What are the official names of this protein?
C4b-binding protein beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: LMO_MYCSM
Sequence: MSNWGDYENEIYGQGLVGVAPTLPMSYADWEAHAQQALPPGVLSYVAGGSGDEHTQRANVEAFKHWGLMPRMLMAATERDLSVELWGKTWAAPMFFAPIGVIALCAQDGHGDAASAQASARTGVPYITSTLAVSSLEDIRKHAGDTPAYFQLYYPEDRDLAESFIRRAEEAGYDGLVITLDTWIFGWRPRDLTISNFPFLRGLCLTNYVTDPVFQKKFKAHSGVEAEGLRDNPRLAADFWHGLFGHSVTWEDIDWVRSITKMPVILKGIQHPDDARRAVDSGVDGIYCSNHGGRQANGGLPALDCLPEVVKASGDTPVLFDSGIRTGADVVKALAMGASAVGIGRPYAWGAALGGSKGIEHVARSLLAEADLIMAVDGYRNLKELTIDALRPTR
What is the function of this protein?
Catalyzes the oxidative decarboxylation of (S)-lactate (L-lactate) to acetate and carbon dioxide.  Its physiological role remains unknown.
What are the official names of this protein?
L-lactate 2-monooxygenase, LMO, Lactate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Protein: SIGA_CHLPN
Sequence: MFMNTQNSQATEVSSEEESQKKLEELVALAKEQGFITYEEINEILPMSFDTPEQIDQVLIFLTGMDIQVLNQIDVERQKEKKKEAKELEGLARRTEGTPDDPVRMYLKEMGTVPLLTREEEVEISKRIEKAQVQIERIILRFRYSAKEAISIAHYLISGKERFDKIISEKEVEDKTHFLKLLPKLITLLKEEDTYLENLLLSLKQPDLSKQEAAKLNDSLEKCRIRTQAYLRCFHCRHNVTEDFGEVVFKAYDSFLHLEQQINDLKVRAERNKFAAAKLAAAKRKLYKREVAAGRTLEEFKKDVRMLQRWMDKSQEAKKEMVESNLRLVISIAKKYTNRGLSFLDLIQEGNMGLMKAVEKFEYRRGYKFSTYATWWIRQAVTRAIADQARTIRIPVHMIETINKVLRGAKKLMMETGKEPTPEELAEELGLTPDRVREIYKIAQHPISLQAEVGEGSESSFGDFLEDTAVESPAEATGYSMLKDKMKEVLKTLTDRERFVLIHRFGLLDGKPKTLEEVGSAFNVTRERIRQIEAKALRKMRHPIRSKQLRAFLDLLEEEKTGTSKVKSLKSK
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA, Sigma-66, Sigma-70, Sigma-A.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_BURVG
Sequence: MSYRELVVELAREHAEALSDALLDLGALSVSVEDADADTPDEQPLFGEPGLVPERTAWQHSRVVALLSPDLEPAVLLAAAANEIGIADTPKFDVREVEEQDWVRLTQSQFEPIPIGERIWVVPSWHDAPDPDALILELDPGLAFGTGSHPTTRLCMEWLEQTVKPGQSVLDYGCGSGILAILARKCGADPVIGIDIDPQAVESARQNSERNHADVTYGLPDACPDGEFDIVVANILSNPLKLMASMLASKVKPGGRIALSGVLARQADEVAAVYARYVDISVWREHEGWVCLAGTRRESH
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BFR_ECOLI
Sequence: MKGDTKVINYLNKLLGNELVAINQYFLHARMFKNWGLKRLNDVEYHESIDEMKHADRYIERILFLEGLPNLQDLGKLNIGEDVEEMLRSDLALELDGAKNLREAIGYADSVHDYVSRDMMIEILRDEEGHIDWLETELDLIQKMGLQNYLQAQIREEG
What is the function of this protein?
Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.  The mineralized iron core can contain as many as 2700 iron atoms/24-meric molecule.
What are the official names of this protein?
Bacterioferritin, BFR, Cytochrome b-1, Cytochrome b-557.
What is the protein family that this protein belongs to?
Belongs to the bacterioferritin family.
Protein: RUVA_CLOP1
Sequence: MYEYIRGQFQGISKDYVVIELNNIGYKIFTSGNTMSNMPKVGEEVLLYLEQIVREDFIGLYGFTTREELEMFKLLLSINGVGAKAALSLLSISTVNNLKYAIMMGDEKHITRAPGIGKKTAQRIILELKDKLKPDELTSEEGELIEGINDNSDYSFNINETLSALMALGYTEKEAQKALEKVDKTLSIENMIKESLKLLMR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PROA_CALBD
Sequence: MNDLIEKAKKVKEASKKLMNLSENEKNRALSCISQKILEKMDFILQENQKDMENAVSKGIKGALLDRLKLTEDRIKQICKGIEDVIKLPDPVGEVISMWKRPNGLVIGQKRVPIGAIGIIYEARPNVTVDAAVLCLKAGNSVLLRGGSEAINSNVALVKVMKEGLLEAGIEEGSIEIVEDTSRETAIAMMKLNEYLDLLIPRGGANLIKTVVQNATVPVIETGVGNCHVFVDESADFEMAKAIVINAKTQRPGVCNAAEKLLVHKNIAESFLPMIVKELMAKGVEIRGCSKTVEICKKNGIEVKEATEDDWYTEYLDLIIGVKVVDSIDAAIEHINKYGSKHSEAIVTRDYFNAQKFLDYVDAAAVYVNASTRFTDGFEFGFGAEIGISTQKLHARGPMGLKELTTIKYIIYGSGQVRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS21_ECOLC
Sequence: MPVIKVRENEPFDVALRRFKRSCEKAGVLAEVRRREFYEKPTTERKRAKASAVKRHAKKLARENARRTRLY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: CAP12_NIADE
Sequence: MIKKRLFIGSSSEELKTAEIVKEVLLKDFEVTIWNDNVWDTAVFKINQNFLADLLKASLQFDFGILIGTKDDKVMFREVEMIQPRDNVLFELGLFTGRLGTSKCAFLIDKEIKLPSDFNGLTLARFDSTNEATVIAGANSIKDLFLASADDEINFFPSATLASVYYENLIVPICRFIIDNNGFTKGDTHYQKCKLNIIVPERINQDVNLQFEKLKGLFTTENVSFKYSGRPRQISVDTQIKNDTLEFIDFPTIITGINHAISNLLPNDFNKQSPDYSSILDRELRRFITTLKKLLIRGGFDEMVNVKRDSEL
What is the function of this protein?
The effector protein for this CBASS system.  Binds c-di-GMP, does not bind cUMP-AMP (PubMed:32877915).  Upon activation by c-di-GMP forms filaments which hydrolyze NAD(+); filament formation is required for enzyme activation (By similarity).
What are the official names of this protein?
CD-NTase-associated protein 12, Cap12, NAD(+) hydrolase, TIR-STING, NdSTING.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the bacterial STING family.