PharMolix/UniProtQA huggingface dataset:
Protein: HBEAG_HBVD7
Sequence: MQLFHLCLIISCSCPTVQASKLCLGWLWDMDIDPYKEFGATVQLLSFLPHDFFPSVRDLLDTASALFRDALESPEHCSPHHTALRQAILCWGELMTLATWVGANLQDPASRELVVTYVNINMGLKFRQLLWFHISCLTFGRETVIEYLVSFGVWIRTPQAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
What is the function of this protein?
May regulate immune response to the intracellular capsid in acting as a T-cell tolerogen, by having an immunoregulatory effect which prevents destruction of infected cells by cytotoxic T-cells.  This immune regulation may predispose to chronicity during perinatal infections and prevent severe liver injury during adult infections.
What are the official names of this protein?
External core antigen, HBeAg, Precore protein, p25.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus precore antigen family.
What are the subcellular locations of this protein?
Secreted. Host nucleus.
Protein: RSMC_SALEP
Sequence: MSAFTPASEVLLRHSDDFEQSRILFAGDLQDDLPARFECAASRAHTQQFHHWQVLSRQMGDNVRFSLVAQASDVADCDTLIYYWPKNKPEAQFQLMNILSLMPSGVDVFVVGENRSGVRSAEPMLADYAPLNKVDSARRCGLYHGRLEKQPQFSLESWWAEYNIDGLTIKTLPGVFSRDGLDVGSQLLLSTLTPHTKGKVLDVGCGAGVLSAALASHSPKVRLTLCDVSAPAVEASRATLAANGLEGEVFASNVFSEVKGRFDMIISNPPFHDGMQTSLDAAQTLIRGAVRHLNSGGELRIVANAFLPYPKILDETFGFHEVIAQTGRFKVYRTVMTRQAKK
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_BACCZ
Sequence: MDKRISIAIDGPAAAGKSTVAKVVAKKLSYVYIDTGAMYRTITYAALEQKVDIENEEQLMEVVKNVKIEFQQGENTQLVFLNGQDVSEVIRTPEVTNRVSIVAKHRLVREEMVRRQQELAEKGGVVMDGRDIGTHVLPDAEVKIFMLASVEERAERRHLENMNKGFDSNLEQLKEEIAQRDKLDSEREVSPLKKADDALELDTTSLSIEEVVQKIMGIVSGVFAK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1798_STRPQ
Sequence: MGFTDETVRFKLDDGDKRQISETLTAVYHSLDEKGYNPINQIVGYVLSGDPAYVPRYNDARNQIRKYERDEIVEELVRYYLQGNGIDVK
What are the official names of this protein?
UPF0297 protein SPs1796.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: PUS1_ARATH
Sequence: MSLLRNFFSFTFSANSIITKPYFAIPIKAMEATSELNLNYPKPISAPPPPISKDIELRRAMEASSKSSLFNLTRDDILYEDEYLMAVNKPKGVYCEAVLRSAPQIVLDSSSEYHLANRLDRDTSGVMIITKSHKVAAKLVKAFTEHKIRKSYIALCIGSSPNWRRVTVSSGHGRSKHGAWRVYAALDVGRVLPGGSFVRDMETTFEVVSVNSVKNESCELEDVNHVIVAEGERELSCGGDDDDVVVVVRAFPRSGRTHQIRLHCQYLGIPIRGDVKYHGVYEWNGRTFEGHELHAECLSLDHPVTGDSIVIRAPLPYWAAGD
What are the official names of this protein?
RNA pseudouridine synthase 1, RNA pseudouridylate synthase 1, RNA-uridine isomerase 1.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: MURG_PROA2
Sequence: MNILFAGGGTGGHLYPAVAMAERLEQLYPGTTVAFVGTERGIEATEIPRLGYRLHLLDVRGFRRGFSFSDMLNNAGVLLDFVRAVVKAAGIIRAEQPDVVVGTGGFVSGPLLAAAELMGRKTLIQEQNAFPGVTTRFLAAFATEVHLSFEESRKFFRRKQGVFVTGNPARSFTGIDQAEAQSFFGLQPGLPTLLVFGGSRGARSINNAVKTWISGAAGKANIIWQTGSLDDERLRKEVEPSATLWIGPYINDMRMAYGAADLVLCRAGASTLAELTNLGKASVLVPYPYATGNHQFFNAKALVDAGAAELVADADIALDQSRTKVFSILADPELRLRMREACRKEGRPEAALDLAGRIAGLANIK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CX7A1_HUMAN
Sequence: MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYSLGWASFPRN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 7A1, mitochondrial, Cytochrome c oxidase subunit VIIa-heart, Cytochrome c oxidase subunit VIIa-H, Cytochrome c oxidase subunit VIIa-muscle, Cytochrome c oxidase subunit VIIa-M.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase VIIa family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: VATD_ANASK
Sequence: MSRAATTRMGLLEVRARRAVAGKGARLLRAKREVLASELWKLVHDVLEGRARLDEALHRAVKALELAKALEGEERLASLALPAARAVPLAVTVRRVWGVPTPSVAAPPLVRAADQRGSSPVSWGPSGAAAARHHEESLEVLLTIASKELHLARLGEEIQETSRRINALEQLVLPALRSEASRIAAALDERDREDAVRLRRFRARHPRPA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: RS16_ANADE
Sequence: MAVVLRLSRAGTHKAPFYHVVATDSRNARDGKYLEDVGIYDPTKRPERIELKVERIEHWLKAGAKPSQTVAMILKRAAKAAAPAAPKA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: RSMA_COLP3
Sequence: MNDKKHLGHQAKKRFGQNFLHNDAVISDIVDAINPEPGENLIEIGPGLGALTEPVIERAGKLSVVELDRDLAHRLRHHPFLAKDLTIYETDALKFDFSELATEEQPLRIFGNLPYNISTPLIFHLLTFKDKVKDMHFMLQKEVVERMAAGPHCKAYGRLSIMTQYQCQVFPVMEIGPEAFKPAPKVDSAIVRLIPHAHIENPVKDINALNTVCLAAFNQRRKTIRNTFKKLITEAQLAELNIDANLRPENLSLDEYKKLADFIVDNPPEAAPVKEKRRMAKNKMTEPANNNLNENSAPEVD
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CD019_HUMAN
Sequence: MGCRCCKIIQSYLFDPVQVPSPGYVNEVNSCKLDEDDTDKLKGKWSSEVLVQKNDPQRQGSKKTESSSRTADPWEPCWPHQGPLPQGDAGGEHHACGVNGIGPAATPQPTGNSSPTQDDRGSWASTANTVPPTQPFLEGGGTRKQDCVLLASEGTQVMRNGDSRAPSEAESFALEVQDHVFQIPAPDYLQHWGPAGDNVDHNEKDCVFKNHTEDESLEGIQPPVGEHGLNTPFSVRRSWDSLNEDVETEVLSICFNEKGPVHAMPVVDSGNRQEDTHGSDGDGDGEIVDEDAAVAEALAALEAATAGEDLDETD
What are the official names of this protein?
Uncharacterized protein C4orf19.
Protein: PQQD_XANOR
Sequence: MSSITRDSQPALRAGVRLQHDRTRDQWVLLAPERVVELDEIALVVAQRYDGTRSLAQIAQELAAEFDADAADIEADVIELTATLQQKRLLRL
What is the function of this protein?
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
What are the official names of this protein?
PqqA binding protein, Coenzyme PQQ synthesis protein D, Pyrroloquinoline quinone biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the PqqD family.
Protein: ACPY_STRAW
Sequence: MPETTTTALDKEQLRELVADVLDLDVAEVTDDADFMEDLDVDSLMALEITVRLEKEYGVRLAEAELTSITSLQGTYELLTSKLGDTR
What is the function of this protein?
Acyl carrier protein.
What are the official names of this protein?
Polyketide-8 synthase acyl carrier protein 2, ACP 2.
Protein: TMPA_TREPA
Sequence: MNAHTLVYSGVALACAAMLGSCASGAKEEAEKKAAEQRALLVESAHADRRLMEARIGAQESGADTQHPELFSQIQDVERQSTDAKIEGDLKKAAGVASEAADKYEILRNRVEVADLQSKIQTHQLAQYDGDSANAAEESWKKALELYETDSAQCLQSTVEALESYRKVAHEGFGRLLPDMKARAGAAKTDVGGLKVAVELRPQLEEADSQYQEAREAEEVNARAKAFSGYHRALEIYTELGKVVRLKKTEAEKALQSAKTKQKASSDLARSADKSAPLPENAQGFSKEPIEVEPLPNDRLNTTQADESAPIPISDTSSPSRVQSRGVEDGGRSPKSSMNEEGASR
What are the official names of this protein?
Treponemal membrane protein A, Antigen TmpA, Membrane protein A.
What is the protein family that this protein belongs to?
To T.phagedenis TmpA.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: TSGA_SALA4
Sequence: MTNSNRIKLTWISFLSYALTGALVIVTGMVMGNIADYFQLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKTQLRFGFILMVLAVAGLMFSHSLALFSAAMFVLGLVSGITMSIGTFLITQLYEGRQRGSRLLFTDSFFSMAGMIFPMVAAFLLARSIEWYWVYACIGLVYLAIFILTFGCEFPALGKHAQHSQAPVVKEKWGIGVLFLAVAALCYILGQLGFISWVPEYAKGLGMSLNDAGALVSDFWMSYMFGMWAFSFILRFFDLQRILTVLAGMAAVLMYLFITGTQAHMPWFILTLGFFSSAIYTSIITLGSQQTKVASPKLVNFILTCGTIGTMLTFVVTGPIVAHSGPQAALLTANGLYAVVFVMCFALGFVSRHRQHSAPATH
What are the official names of this protein?
Protein TsgA.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: AROB_NITMU
Sequence: METVTVNLVSTPAQRGYPIHIGANILTQPELILDYLDQKRVAIVTNTTVGPLYLEKFRADLSVHGMVSVPIVLPDGEEYKNWETLNLIFDALLTHRCERNTPLIALGGGVVGDLTGFAAATYLRGVPFIQVPTTLLAQVDSSVGGKTGINHPLGKNMIGAFYQPQAVVADTSTLDTLPDRELRAGIAEVIKYGLIRDPAFFDWIESHIELLLRRDNSILTDAIKRSCQHKAEVVEEDERESGMRALLNLGHTFGHAIENAMGYGNWLHGEAVAAGTMLAAEVSRRMGMIGEEDVDRVRNLYVKTGLPVIAPNLGPEKYLHLMGLDKKVQGGKMRFILLENIGRATVHADVPAAILTEVLTECTADA
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4087_PSEU2
Sequence: MPSFDVVSELDKHEVTNAVDNAIKELDRRYDLKGKGTFEFKELTVTLTAEADFQLEAMIEILKLALVKRKIDAKCLEIKDAYASGKLMKQEVILREGIDKELAKKIVAHIKEAKLKVQAAIQGEQVRVTGKKRDDLQEAIAALRAYDSGMPLQFNNFRD
What are the official names of this protein?
UPF0234 protein Psyr_4087.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: XPT_STAAE
Sequence: MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_NITMU
Sequence: MLVIGLTGGIGSGKTSAANIFSALGAGVVDTDEIAHELTQSGGRSLPAIRRAFGEKYITPEGALNRKEMRNLVFNDTDARRKLEAILHPLIRDEVSRRVGLAQGPYLIIVVPLLLETGHYRGIVQRVLVVDCSEGAQISRATARSGMNEQAVRAIMVAQVSRDERLGQADDVIVNNADLPNLERQVRALHKKYMTLAQGS
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF2_TRIV2
Sequence: MTHWITLLAVEEVAKEGGLFDLDATLPLMAIQFLLLALVLNATLYKPLGKAIDGRNEYVRNNQLEAQERLSKAEKLAEAYEQELAGARRQAQTIIADAQAEAQKIAAEKVAAAQKEAQAQREQAAGEIEQQKQQALASLEQQVDALSRQILEKLLGADLVKQR
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).  The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
What are the official names of this protein?
ATP synthase subunit b', ATP synthase F(0) sector subunit b', ATPase subunit II, F-type ATPase subunit b', F-ATPase subunit b'.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: HSL17_DICDI
Sequence: MTILASISSIGNVKSISKSNNLSSLSNSSSSLQSMNSIQCGGCGNGGLLGAVGGLVGGVLTGTGVIVGSVLHGVGSILTGGSNNCGCN
What are the official names of this protein?
HssA/B-like protein 17.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: LGI4_MOUSE
Sequence: MGGAGILLFLLAWAGAGVAWSPPKGKCPPHCSCSKENTLCEGSPELPESFSTTLLSLSLVRMGVSRLKAGSFLKMPSLHLLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNKIGSISKNALRGLRSLTHLSLANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPPAVAQIQLNHLDPKKFKCRATELSWLQTVGESALSVESFSYQGEPHMVLAQPFAGRCLILVWDYSLQRFRPEEELSAPSVVSCKPLVLGPRLFILAARLWGGSQLWSRSSPDLRLTPVQVLAPQRLLRPNDAELLWLDGQPCFVVADASKAGSTTLLCRDGPGFYPRQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHWVGGRFERRTDIPEAEDVYATKHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGSHVFQPLLIARDQLAILGSDFAFSQVFRFESDKGILEPLQELGPPALVAPRAFAQVTVAGRRFLFAACFKGPTQIYQHHELDLSA
What is the function of this protein?
Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation.
What are the official names of this protein?
Leucine-rich repeat LGI family member 4, LGI1-like protein 3, Leucine-rich glioma-inactivated protein 4.
What are the subcellular locations of this protein?
Secreted.
Protein: DNLJ_ECOL6
Sequence: MESIEQQLTELRTTLRHHEYLYHVMDAPEIPDAEYDRLMRELRELETKHPELITPDSPTQRVGAAPLAAFSQIRHEVPMLSLDNVFDEESFLAFNKRVQDRLKSNEKVTWCCELKLDGLAVSILYENGVLVSAATRGDGTTGEDITSNVRTIRAIPLKLHGENIPARLEVRGEVFLPQAGFEKINEDARRTGGKVFANPRNAAAGSLRQLDPRITAKRPLTFFCYGVGVLEGGELPDTHLGRLLQFKKWGLPVSDRVTLCESAEEVLAFYHKVEEDRPTLGFDIDGVVIKVNSLAQQEQLGFVARAPRWAVAFKFPAQEQMTFVRDVEFQVGRTGAITPVARLEPVHVAGVLVSNATLHNADEIERLGLRIGDKVVIRRAGDVIPQVVNVVLSERPEDTREVVFPTHCPVCGSDVERVEGEAVARCTGGLICGAQRKESLKHFVSRRAMDVDGMGDKIIDQLVEKEYVHTPADLFKLTAGKLTGLERMGPKSAQNVVNALEKAKETTFARFLYALGIREVGEATAAGLAAYFGTLEALEAASIEELQKVPDVGIVVASHVHNFFAEESNRNVISELLAEGVHWPEPIVINAEEIDSPFAGKTVVLTGSLSQMSRDDAKARLVELGAKVAGSVSKKTDLVIAGEAAGSKLAKAQELGIEVIDETEMLRLLGS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RL5_LEPIC
Sequence: MAARLRTKYKKEIVPELNKKFKFSSIMQVPRLEKIVLNVGMGEAHTNPKALEAAVEELALITGQRPVKTKAKKSIAGFKIREGMSLGCMVTLRGDYMYEFLDRLVNVALPRVRDFKGVSEKGFDGRGNYNMSIKEQIIFPEIKVDKINTLYGINMTFVTNSKSNEEAYSLLAAFGMPYRNQK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: AAAT_MACFA
Sequence: MVADPPRGDSKGLAAAEPTANGGLALASIEDQGEAAGGCCGSRDRVRRCLRANLLVLLTVVAVVVGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVALALALQPGAASAAINASVGAAGSAENAPKKEVLDSFLDLARNIFPSNLVSAAFRSYSTSYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSEQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTEVRSTEPELIQVKSELPLDPLPAPTEEGNPLLRHYRGPAGDATVASEKESVM
What is the function of this protein?
Sodium-coupled antiporter of neutral amino acids.  In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (By similarity).  The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation.  Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way.  Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (By similarity).  The transport cycle is usually pH-independent, with the exception of L-glutamate.  Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion.  May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (By similarity).  Can transport D-amino acids.  Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (By similarity).  Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity).  Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (By similarity).
What are the official names of this protein?
Neutral amino acid transporter B(0), ATB(0), Solute carrier family 1 member 5.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Melanosome.
Protein: PPARG_MACMU
Sequence: MGETLGDSPIDPESDSFTDTLSANISQEITMVDTEMPFWPTNFGISSVDLSVMDDHSHSFDIKPFTTVDFSSISAPHYEDIPFTRTDPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
What is the function of this protein?
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids.  Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase.  It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.  Key regulator of adipocyte differentiation and glucose homeostasis.  ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer.  Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses.  Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.
What are the official names of this protein?
Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation (By similarity).
Protein: HEMH_PSEFC
Sequence: MTDHALLLVNLGSPASTSVADVRSYLNQFLMDPYVIDLPWPVRRLLVSLILIKRPAQSAHAYASIWWDEGSPLVVLSRRLQQQMTAQWTQGPVELAMRYGEPSIESVLTRLAGQGISKVTLAPLYPQFADSTVTTVIEEARRVVRDKQLDLQFSILQPFYDQPEYLDALVASARPHLQQDYDHLLFSFHGLPERHLNKLNPGHSLEGSGDCCANASPEVRTTCYRGQCFSVARDFAARMGLPDDKWSVAFQSRLGRAKWIEPYTEARLEALAQQGVKKLLVMCPAFVADCIETLEEIGDRGLEQFREAGGEELVLVPCLNDDPQWAVALNTLCERAPVSL
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2C44_ARATH
Sequence: MGFLDLPFMLKAFRFRRLVVEDGKRRKKKKPLWLTPVSHGYYTVDRLSYADNSSNDDSVFVQREQQSDELEIWLFGVSNAGTGKEIVKYMQNHLFDKLPNELGIMRKCKETMRRAYVEEERTGGSAASVMVVNGEKLAIASIGDHRVVVCKDGEAHQIRDRKASTKHWSQFIFPVCNQGEEEDESDPRNSELVVITEKINSDTEFIIIGSPGIWEVMKSQEAINLIRHIEDPKEAAKCLAKEALNRISKSSISCVVIRFG
What are the official names of this protein?
Putative protein phosphatase 2C-like protein 44, AtPP2C44.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
Protein: RL28_BACC7
Sequence: MARVCAITGRKARSGNSRSHAMNATKRKWGANLQKVRVRIDGKVQRVYVSARALKSGKIERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.