PharMolix/UniProtQA huggingface dataset:
Protein: RLMN_COXB1
Sequence: MTEKINLLNLSETELQGFIASQGQPLYRATQLLQWIHQRGVTDFSLMTDLSKPFRQQLSEASFVRVPELALERVSADGTHKWLFRLADNNKIETVFIPDRKRGTLCVSSQVGCALNCSFCATGKEGFNRNLTLAEIIGQVWLAARLLKSPYKITNVVMMGMGEPLLNYEAVVAAMHLMMHDHAYGLSKYRVTLSTSGVIPAMRRLREESPVSLAVSLHAPNDALRNVLIPLNKKYSLDQLIPLCRDYYSRGSKRCVTFEYVMIEGMNDRLIDAKQLIRLLADVPCKINLIPFNSFQGTAYRCSTESAISVFQKCLMDAGFNTRVRRTRGDDIAGACGQLAGQFHDRTGRHQRWVQKQGHDFNRPIPAIDH
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y9801_DROME
Sequence: MPSLRQKVTTYFRQLSFIAEPREGRRRASEHEDDDGSFITKYLEGRMQRQFVEGPEIYNGQNPTDMPVLKLDTYEAGNCSITAACTGPDEGLTGIKRSKLHLSTSFADDIDFIDTQQENDDCYGVRRSTPPVQVATQNSTRLTSKFGRPPAGPRRQSSAEQPSGSASASGMRSRKNSKSSIANLAAASAGTDAGKANSDQNNRNVLNAKTEVSTDGDPNSERERLLREAVSNQGGSDPAALIAGVENWRMECDFAYGISVSLYETNMLTKEPMGNPIADCYGMVVRGDSAAMAMADGVNWGDGARLAARSAVHGCLDYLDRAVFGQALECRATTTQEVFVSLLRSLWEGHGCILEVGGALSTLTIAVVLPLDGAPGKYVVCSCNVGDSLGYVYSKKHGVRELTQASHDISSMRDMRDALGALGPADGNKPELSNLTFSMTCIESGDIVFLTSDGISDNFDPVVGKFAEAWTPDVKLQTSGHVKPANLAPKRQNKSASAIYARLHPSTPPTRPARQSKAESPPNNAPSRPKYMRSQTLIEPRQGLVSAPPPSVVPQRIPKSISGLPLVTGPQRHALTLYRLEDLLSYGINGTFSPCVSARRLCHLLIDFVRMITSARRKTLEQRELFYKLSTGPDGAKREVQLNRMQHRAARKRVVDSSAFVALPGKLDHATVMAYTVGGGEEHNNGNENGDGGAISPVLQSKEFKETNF
What are the official names of this protein?
PP2C-like domain-containing protein CG9801.
Protein: Y3040_BACC2
Sequence: MKKTFYHYMMKHRAALFRNEISDLAEAMYDDLSFPKQSEDYDEISSYLELSGMLESMSIFDEAWDLYIQDR
What are the official names of this protein?
UPF0346 protein BCG9842_B3040.
What is the protein family that this protein belongs to?
Belongs to the UPF0346 family.
Protein: NORM_STRPN
Sequence: MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNTMDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLGRGKKEEVASDFYQFIYLALGLSVVLLGMVLFLAPIILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLTKLSMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQEKLKALHLEKRIPLNMDKIKEGVRLGLPIGGTVFAEVAIFSVVGLIMAKFSPLIIASHQSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRWTALIFAAFTLTFLYIFRGNVASLYGNDPKFIDLTVRFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYLGLLGYWGVAIPVRTLFDSLTDFGAYSYWIGLIISLIVSGALYRWRLTVIMKRFESLAKSKC
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYV_CHLTE
Sequence: MSDHSAQNLEKTYNHHEVEERWRSAHWEAIGTFHAEHSRVLKEGATPYTVLMPPPNVTGSLTLGHVLNHTLQDIFIRYARMMGKEALWLPGTDHAGIATQTVVEKKLRKEGVTRHDLGRRDFLDKVWEWREEYGGLILRQLRKLGISCDWRRNLFTMDERASEAVINTFVALYREGLIYRGRRIINWCPVSQTALSDEEVIMKSRRDKLVYISYPLAKDPTRSITIATVRPETILADVAIAVNPNDERYADLIGELVIVPIAGRHVPVIADDYVDIEFGTGALKITPAHDPNDYEVAKRHNLPVFSVIGKDARMTDECGYAGMDRFDARDKIVADLAELGYLVKLEEYEHNVGYSERADVVVEPYLSEQWFVKMQPLAEPALKVVNDGEIRFHPEHWINTYRHWMENIQDWCISRQLWWGHRIPAWYDDKGNVWVASSYEEACHLAGTDKLSQDEDVLDTWFSSWLWPLTTLGWTGPHSDNDDLRAFYPTDTLVTGPDIIFFWVARMIMAGLHFKGDVPFRDVYFTSIIRDMKGRKLSKSLGNSPDPLKVIDTYGTDALRFTIVYIAPLGQDVLFGEEKCELGRNFATKIWNASRFVFMQREKLFATREEFVEAFANFTPQRELMSSAGRWLMSRYNAMLERYHQAMANFKVNDMVKIVHEFFWGDYCDWYVEALKSELTGDITEERGRHAVCLAVSVLEGVLKALHPVMPFITDEIWHAIAPRSAEETIATEAMPQPDASWRGEDAAAFDLVRNMVSEIRSLRSAFNVPHDLRAQAVIRASSPAALVALQTGRAIFPAMTKCEVELGESVERPAHSAASVVDGNELFIKLEGLISFEKEKQRLEKEITKVTAYIESLEKKLSNEKFVSNAPADVVAKEKEKLEESRSMVLKLQGNLEVLS
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FYV8_CANGA
Sequence: MDESQVERKKSYRWVSASQATYDGAGWDSSSESETETRSQPKLGKLDESLPSLPKLNYDNTDVSQYKEEDDEDTDNRTEKAGEIGAGTLHSNSEIQNDVIVEDDPVIKQTPDMIDKDTLLTSPTAHKESSPSPNGSRHTFSRRPLPNRAVNEHLDDLMLEISKELTPKPEQEAVFGNHSPRKDIDSDLPNGKEDQKLNGSRLGLLNESIDNESDMPSVDETRSKDVDENGEKDREDRFDYYDDDSEFSIDSEIKQAQKASLEELQSEFDSDPQTSNIAKSLEGMNLEHDAEEESVKTNRDSNVSDLQKDQREINESNIENSDNDSLELPLTESSSDELESADHGDALSFTESIQYDQSDGDSEPNQGDDASLVSNRVQQNNVNTDAESADDIAKDKMDDHASGMDFEEDEVLNSTLTDGDVHVHKSGYFKKLVAEELGDKKLDDGKSLNNVASTQTASTEDKVASDTEDVQESKADNDDTKNDAHVSSNRSSVTSEEWRPDTDALRDGFMQKTGDNPPPGFVRDEKGELVDLTPASMKPRVVSTYSEIESTWNAFPSEDADDLETIRDTKTLYDNSTLYNVPGIMTNNDALPPLPEDASLYRDSNQSDAVGSQDRARAASVTRKVSKEGVNIAQPTSQEINKLSEQNTMPTRDLNKIISSNSTHAIKLENLRDYRNTLDNFDSGLQTWIAYTLKSSSKTDRDFIFQEYKSNSHVREAYANADDLSRKNTVINTVTNVNQNVNHLRKKVLQHSLKPKTLFSSISKKKL
What is the function of this protein?
Involved in the resistance to unfolded protein response (UPR)-inducing agents.
What are the official names of this protein?
Protein FYV8.
What is the protein family that this protein belongs to?
Belongs to the FYV8 family.
Protein: F16PA_RHOP5
Sequence: MEHALTLSQHTREYAGTDPLRLAVAAAIDAIAEASIEMAELIGRGALAGITGEAQGSSNADGDVQKDLDVRCDEMILEALKKLPFAALASEESEALVYGDPMAPISVAFDPLDGSSNIDTNATVGTIFSIIPTIVGVAPFTAPGKVQLAAGFVVYGPQTSLVLTTGDGVDIFTLDRAAHVYKRIRHKVRIPTDTPEFAINASNHRHWEQPVRDFVEECLAGTEGPRSKDFNMRWLGSLVAEAYRILTRGGVFLYPGDGRPGYSEGRLRLLYECHPMAFIMEQAGGGASTGREHVLDLAARTIHQRAPLIMGSIDKVNRVELLHNDPDAASRSAPLFARRGLFRV
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_ACTSZ
Sequence: MPIQILPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIQIDIENGGATLIRIRDNGFGIPKEELSLALARHATSKIATIDDLEAILSFGFRGEALASISSVSRLTLTSRTADQQEAWQVFVQGREQESTVNPASHPVGTTVEVANLFFNMPARRKFLRTDKTEFGHIDEVIRRIALAKSHIAFTLTHNGKIVRQYKSAVEDTQKLKRLAAICGNDFVRQALYIDWKHDNLHLSGWVTTPTFARQQNDLSYCYVNGRMVKDKVINHAIRQAYAEHLGSERYPAFVLFLDLNPNDVDVNVHPTKHEVRFQQSRLIHDFIFQGVTNALLSAEQFDFSASTESEKNNEIREPQADYQNVTPTIRPNRAAAGQNMFELNSPTQTKQTNVPITTKAYPTPAHSGQAGYSTTPSNPPPHFMPQSARSVSPFEREKVTKTEQRIYAELLKTPEVEAPPTSIQSSLLSSSSLLHAVALVNNQALLLQRDTAFYLLPLNKLQKMRLELLLTLPNTPQQMLLIPVVFRLSDKQQAQWRQQKIWFEQSGFEFIENPVQHRITLNAVPQCLRHQNLQKIVIALLNRSLQKTEKFLTALLDLVELPDCQVLANAVNILQETELLLDQQTTMKLDNLLIPIDFSSYLS
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: CYF_SYNJB
Sequence: MKRIGLVFCALLLLLGMGARPAAAYPYYAQMAYDNPREATGKIVCANCHLNAMPTRAEVPQAVTPGQVFTIKVGIPYDLSKQQVLADGSKGGLNVGAVVVLPEGFRLATEAEMTEEQRQETAETYITPYSDAKPNILLVGPLPGEQHQEIVFPVVAPDPKEDPSVAFMKYRVYIGANRGRGQLNPDGSLSNNNVFRAPATGRLVNIATLDSDISDLPAELASLVPPEYELPGTRVLSFESESGIHNLVVPPGPELVVAVGDSVKEGDPVTNNPNVGGFGQVERDLVLQSPDRVKWLVAFLAAITITQVLLVLKKKQVELIQAAEILG
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome f.
What is the protein family that this protein belongs to?
Belongs to the cytochrome f family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: SYC_LATSS
Sequence: MLTVYNTLTRQKETFKPLEEGRVKMYVCGPTVYNYIHIGNARSAIAFDTIRRYLEYRGYQVDYVSNFTDVDDKMIKAANAENITVPELADRYITAFKEDTKALNIEPATLNPRATDNIEEIVAFIQDLIAKDYAYAVDGDVYYRARKFKAYGHLAGQDLDQLEQGASEHTATEETLRKEDPIDFALWKAEKGNEIAWESPWGKGRPGWHIECSVMSTKYLGDTIDIHGGGQDLEFPHHENEIAQSEAKTGQTFVNYWLHNGFVTVGDDDQKMSKSLGNFVTVHDLIQEVNPQALRFLMSSTQYRRPIRYSQSLLAEAQTNLDRLKTTLDNLAFRQPTAEPGEDQIVMDKAAELEAAFVTAMDDDFNVQNGLTQLYELAKLSNQYLEQPTVQSDTLTSLATRLTRLLAIFGVVFKADQLLDTEVESLIEERQAARAAKDFAKSDAIRDQLKAQGIILEDTPQGMRWRRA
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_SHEWM
Sequence: MSVKDKLEIYLRLARMDRPIGTLLLMWPCLMALVLAAGGMPDLKVLVIFIIGVVVMRACGCIINDYADRKLDSHVERTKSRPLASGEVSVKEALTLFVVMGLIAFGLVLMLNPLVVQLSFVGIILTIIYPFTKRFTNMPQMFLGVVWSWSIPMAYAAQTGTVPAEAWWLFAANWCWTVAYDTMYAMVDRDDDLKVGIKSTAILFGKYDRQVIALFQLAALACFIIAGWAADRGLVYALGIITFVGFSLYQQKLIYGRERAPCFKAFLNNNWAGLSLFVALGVDYLV
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RNPH_METCA
Sequence: MRPSGRRPDQLRRIAFTCNYTKHAEGSVLVEFGDTRVICTASVEERVPPFLKGKGSGWITAEYGMLPRATHERTGREAARGKQGGRTMEIQRLIGRSLRAALNLEALGERTVTLDCDVIQADGGTRTASITGGYVALVLAVQRLLKSRKIKTNPVHGQIASVSVGICQGVPVLDLDYAEDCDAETDMNVVMNDAGAFIEIQGTAEGHAFRRDELDAMLRLAEAGIADLLLHQQEALDGCGIKS
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: Y3603_CHLAA
Sequence: MISLRIHEQPIHDQPRERLARQGAGALSDAELLAILLRVGTNGTNVLQLAQQLLAESGGLQGLQRLDFQELCRLHGMGVSKAASVKAALEIGRRLARSAIEERFPIRSPADVATLLLVEMSHLDQEHLRTILLDTKNRVQQITTVYIGSLNSANVRVGEVFKEAVRRNSAAIIVVHNHPSGEPTPSMEDIEITRQLVSAGRLLDIEVVDHLIIGNGRYVSLRERGLGFE
What are the official names of this protein?
UPF0758 protein Caur_3603.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: RL5_ACIAD
Sequence: MARLKTRYNEELKAKLQQELGIKNVMEIPRITKITLNMGVGAAATDKKLLDGAVADMQLIAGQKPVVTLARKSIAGFKIRDGWPIGCKVTLRGEQMYEFLDRLISIAIPRIRDFRGFSSKSFDGRGNYSMGLKEQIVFPEIDFDKIDRIRGMDITITTTARTDDEGRALMRTFGFPFK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RL15_BRUSU
Sequence: MKLNDLRDKPGSVKARKRVGRGIGSGTGKTGGRGVKGQKSRSGVSINGFEGGQMPIYRRLPKRGFTNIFAKSFNVVSLGRIQAAIDAGKLDAKAVVNLDSLKAAGVIRRAKDGVRILSDGELKAKVAFEVAGASKAAVEKIEKAGGSIKLPEAAAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ACP_SHISS
Sequence: MSTIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDYINGHQA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MLB_SCYCA
Sequence: BZIBYKMGHFRWGAPMDK
What is the function of this protein?
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.
What are the official names of this protein?
Melanotropin beta, Beta-MSH.
What is the protein family that this protein belongs to?
Belongs to the POMC family.
What are the subcellular locations of this protein?
Secreted.
Protein: FBL77_ARATH
Sequence: MDELPPELWIKILSRINDSESLARCRVASKTLNSLSREVRAVNLICTWSRYLKSRSIVVVTPFKTIFRSLIENSSKIRSISVGVDKALKGMSFDDFNEEDSKDLYLTDVEFVKEWLPRVREDLENLSISDFWIQSCWRKSDILALISSNCSKLVKLEVKNAWLSVVGLTEMPNLRYLTLEFIRLDDENLEKVNDCFPFLQELNLIGVGGLKEPRIHFLHLKSCHWTVSNAPLSLAIVAPNLLELKLKCNKPKSLLVETPKLVQCHLSVEDAEGVSFGEFQDLKTLELVSPDMYRLISNISFGNKIKKLAVDSVKSIEQSERLELGLATILKAFPGITSLSLSPRTWSDIETHFQSQGGLGDMKGTDSLKQITARVQMSDHTNVHQTVSFIRSIVNKYRGLTDMRLMIHQDKDPRVRSNLISTCMMSNPRVRWKWGMWAEGGEDMWV
What are the official names of this protein?
F-box/LRR-repeat protein At4g29420.
Protein: DAPD_NEIG2
Sequence: MSLQNIIETAFENRADITPTTVAPEVKEAVLETIRQLDSGKLRVAERLGVGEWKVNEWAKKAVLLSFRIQDNEVLNDGVNKYFDKVPTKFADWSEDEFKNAGFRAVPGAVARRGSFVAKNAVLMPSYVNIGAYVDEGAMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQAAPTIIEDNCFIGARSEIVEGAIVEEGSVISMGVFIGQSTKIFDRTTGEIYQGRVPAGSVVVSGSLPSKDGSHSLYCAVIVKRVDAQTRAKTSVNELLRGI
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABH_PROM9
Sequence: MEGIKFNQIGVSFKGSGSYVPDQILTNETISQKVDTSDEWIKSRTGISERRISGLGDNVNDMAYEAALSAIEMTNWDIKTIDLIVLATSTPHDLFGSAPSIQAKLGAHNAVAFDLTAACSGFLFALITASQFLKGGSFKRAIVIGADQLSSFVDWNDRRSCILFGDGAGALAIEATNEFDNFLGFDMRTDGERGSFLNLPSKNNKDLIIDNIDFLNGGFSPIQMNGQEVYKFAVREVPIILDNLFRKTNYTSDEVDWLILHQANQRILDSVGDRLKIPREKILSNLAKYGNTSAATIPLVMDEAIRNNRIKQNDIIATSGFGAGLSWGAALIKWG
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_PERMH
Sequence: MSVIVDIRGREVLDSRGNPTVEAEVVLESGVVATALVPSGASTGETEAVELRDGDKNRFKGKGVLKAVDNINTKIADLLIGENALDQVRIDRLMLELDGTENKSNLGANAILAVSLAVARAAAMELDIPLYRYLGGTNAKVLPVPLMNVINGGAHADNNLDFQEFMIVPVFGGRFKEALRCGVEIFHTLKTVLKDKGYSTNVGDEGGFAPALNSTKEALDILMDAIKKAGYEPGEDVLLAIDAASTEFYDKERKVYRFEGEELTADDMIVLYEEIEGTYPIISIEDGLAEDDIEGWKKLTKALGDKIQLVGDDLFTTNPKLIKKGIEEGIANSVLVKLNQIGSLTETLDAIELAKVASYTNVISHRSGETEDTFIADLAVATNAGQIKTGSASRTDRIAKYNQLLRIEEELGEDAVFKGKEAYSKFIR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: FBRL_PHYPO
Sequence: XFEGRGGFGGRGGGDRGGRGXGGFGGG
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins.  Involved in pre-rRNA processing.  Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA.  Site specificity is provided by a guide RNA that base pairs with the substrate.  Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.  Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).
What are the official names of this protein?
rRNA/tRNA 2'-O-methyltransferase fibrillarin, 34 kDa nucleolar protein B-36, Histone-glutamine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Fibrillarin family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Fibrillar region of the nucleolus.
Protein: TRMD_SYNWW
Sequence: MKIDILTLFPEMFVSPFNESIIKRAREQGIITINITNIRDFAQDRQQQVDDYPYGGGAGMVLKANVLGTAIEEVKGPDTWVLYMSPQGKPLNQDRVWELARRKELLIVCGHYEGIDERVMAMVDEEISIGDYILTGGELPAMVLVDAIARLIPGVLGDENSAMEESFSCSLLEYPQYTRPASYGEQEVPEVLLSGHHENIRRWRKKQSLLRTLLKRPDLLLKKCFDEEEKSLLEEILFHRENKR
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRIZ2_CAEEL
Sequence: MLLRISVLFLLLGSCGALFGKRQKCEQITIPLCKGIGYNMTSFPNSYGHEKQEEAGLEVHQFYPLVEVGCFQHLKFFLCTMYTPICQENYDKPILPCMELCVEARSKCSPIMAKYGFRWPETLSCEALPKMSDQMSTGNICAAPPDTPKKQHKGHHHKNQNQNQNQNHNYSPDGPEVGISKIDNEVIAGPSECQCTCNQPFQFVASEKSKVGNVTNCAYSCHSPALAESHSLVSNWMAFWSITCCVLASFTFLTFLIETDRFQYPERPIFMLAFCQLMVAVGFMIRYFVGHEEIACDSMRIKGADDNSGSLCFVVFLLTYFFGMAASVWWVILSLTWVLSAASKWSPEAISSFSFHFHVVGWCLPAIQTVLVIVFNAIDGDPITGICYVGNTDLQFQRIFVLFPLLVYFIVGVLFLVIGFCNLWSIRNEVQKQHPSLESAHKITQLMSKIGIFSLLYTIPSLLIICVLFYEQNHRSLWEQSQLCSCSPKQTIGDSSLIISLIKTCCMCILGWTSGFWVCSTKTLSSWKNAICCLGSSRSLPKYQPADILYAKSDMSSSQFYNTSLRHNHLYGGIPDKL
What is the function of this protein?
Receptor for Wnt proteins (PubMed:19855022, PubMed:20711352).  Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase.  Both pathways seem to involve interactions with G-proteins (Probable).  Required for the migration and axon formation and guidance of different neuronal cell types including canal-associated neurons (CAN), hermaphrodite-specific neurons (HSN), anterior lateral microtubule neurons (ALM), and the right Q neuroblast (QR) and its descendants (PubMed:16109397).  Directs ALM migration through frizzled protein mom-5 and Wnt ligands cwn-1, cwn-2 and egl-20 (PubMed:16109397).  May act redundantly with mom-5 to direct CAN migration (PubMed:16109397).  Plays a role in the organization of head ganglion cells (PubMed:16109397).  Probably by acting as a receptor for Wnt ligand cwn-2, plays a role in the positioning of the nerve ring and may in addition positively regulate the neurite outgrowth of RME GABAergic motor neurons along the anterior-posterior axis of the body (PubMed:19855022, PubMed:20711352).
What are the official names of this protein?
Frizzled-2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RPIA_RHOP5
Sequence: MSSDELKRQAAAVALEQVRDGMKLGLGTGSTAKHFVELLGAKVQGGLQVVGVPTSEVTRADAERCGIPLATLDEVDHLDLTVDGADEIDPALNLVKGGGGALLREKIVAAASGRMIVIADDSKLVETLGRFPLPIEVIPFGLAATRRAIEQALAVCGIDGELKLRNGKDGHAFVTDGGHWIVDAHLGRIPDAPRLAGLLSVIPGIVEHGLFIGLASSVVLASPHGIRIIERPACRDSGESK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: HIS5_PHOPR
Sequence: MASTNQKVVIIDTGCANVSSVRFAIERLGYTVTISKETSVVLNADKLFLPGVGTASEAMKNLQERDLVELVKQVDKPLLGICLGMQLLGALSEEQGQNGKELVPCLHLCDAPIKKLKTGNLPLPHMGWNTITPIDNHPLFQGIPAGSYFYFVHSYAMPVSTGVNDYTIAQCEYGQPFSAAIQSGNYYGVQFHPERSSKAGSQLIKNFLEM
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_STRPZ
Sequence: MQLLEERILTDGNILGENILKVDNFLTHQVDYRSMKAIGKVFAQKYAEAGITKVVTIEASGIAPAVYAAEAMDVPMIFAKKHKNITMTEGILTAEVYSFTKQVTSTVSIAGKFLSKEDKVLIIDDFLANGQAAKGLIEIIGQAGAQVVGVGIVIEKSFQDGRRLIEDMGIEVTSLARIKNFENGNLNFLEADA
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.