PharMolix/UniProtQA huggingface dataset:
Protein: BFR2_KLULA
Sequence: MGKKSLAEQIADIANKPQVEDFDIENDEGVFQHGGSDSDVSSGDESEEELKKQHYVAVGKSKLRNVVDQGLAVKDKKYVGSKGSRAELFNDEEMDAPEQGESESEAESGSEESDAVSFRSDSEDVSESEATSESEIEKDREEDEETAMKKEKLAKIVQTQTKQVINNLAHSAQRDASKGYAILQQNKFFDKILDSRIKLQKALSASNQLPLSQQSWDELLDENNSKLLTSTFKVLEKVLTQCVTVRHKFQIGDHINQSENPSDFDNSKKRSFKELVHETVTLDSDLKSYRSAVLNKWSAKVSASSGKSLLQASKFKAINQSADVQVDNQLADMPRLLKRTKLNRSNTKPLLFDEDLQKGLLKELQLEENVEGDIEEENNLDIPKNYDPRRKDNNALDFTQNPYIYDDEDFYRVLLNDLVEKKISNSQQSNGVTLAITSRSENKLKKNIDTKASKGRKLNYSIQEPIANYEASVNTGYKWSDEQIDEFFAGLLGQKINFNEDDELEADTMHNEEDEEIKNDDIQIFG
What are the official names of this protein?
Protein BFR2.
What is the protein family that this protein belongs to?
Belongs to the AATF family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TPBGL_HUMAN
Sequence: MAPRAGQPGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVRGGPALLAALDAALAPLAELRLLGLAGNALSRLPPAALRLARLEQLDVRLNALAGLDPDELRALERDGGLPGPRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDRPLLDLDGARLRCADSGADARGEEAEAAGPELEASYVFFGLVLALIGLIFLMVLYLNRRGIQRWMRNLREACRDQMEGYHYRYEQDADPRRAPAPAAPAGSRATSPGSGL
What are the official names of this protein?
Trophoblast glycoprotein-like.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: AROQ_BUCA5
Sequence: MKNNINILLINGPNLNLLGTRETEIYGDITLPDLLKNLEKRAKKLNMSLKHIQSNAEHVLIDKIHSSRKNINYIIINPAAFTHTSIAIRDALIAVEIPFIEIHISNIYSREDFRSHSWLSDISQGVICGLGLDGYHWALETISNRLIHLK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: DEF3_HUMAN
Sequence: MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMDCYCRIPACIAGERRYGTCIYQGRLWAFCC
What is the function of this protein?
Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766).  Possesses the ability to neutralize bacterial toxins such as B.  anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed:15772169, PubMed:18435932, PubMed:25963798).  Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed:17142766).
What are the official names of this protein?
Neutrophil defensin 3, Defensin, alpha 3, HNP-3, HP-3, HP3.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PHNC_NOCFA
Sequence: MSADSRAEVVLHAEAVTKRFGATLALDAVSMTVHRSELVVLLGLSGSGKSTLLRCFNGLHPVTSGAVTVAGTRVDTAPRATVRALRRDIGFVFQQFNLVGRLSCLDNVLLGGLARLRLPRYGALTYPKRMRAEAVAHLDRVGLADLAHRRTDTLSGGQQQRVAIARTLMQRPKLVLADEPVASLDPENAGVVMDLLFRICLEDNLTVVCTLHQVDLALGWAHRVIGLRDGRKVFDRPAAGLSRDEVMAIYQRAEVTRSAPAGLAAGAL
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: EIPR1_CAEEL
Sequence: MSECLMFGMDCEARCMTSMTADEENICFLVGTNNIKNDKNQVNKLFMDPEASRLMSKTFRHPAGEVRAIAAHPTKSTILATCTADFSSLGGTHSITIWNIEEDKRTLETVSRLPTEQVMSCLEWEPNSMKCAAMTPFRPEIQLLNMENGPEIVQNLKIPLENEEDEMFSATWSPHHDGNMLGVTGGRTAWCIDCRTDNEYLKIRDAHIHRTISMDFNPNLQHVIATCGDDGYVRIWDTRSTSSALTSLHPHAHWVWSVRFHPVHDQLLLTGGSDASVVLSCAQSVSSEQQIEFRDDEEEEEDDDLVEKLQDGQLERIDEHEDSVYACAWSSADPWTFASLSYDGRMIVSNVSRKHKYALMQL
What is the function of this protein?
Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the endosome-associated recycling protein (EARP) complex.  Important for neuronal function.
What are the official names of this protein?
EARP-interacting protein 1, Endosome-associated recycling protein-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EIPR1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The cytoplasmic localization is supported by the over-expression of an eipr-1-GFP fusion protein.
Protein: RT25_RAT
Sequence: MPMKGRFPIRRTLQYLGSGDVVFKESVKVMTVNYNTHGELGEGARKFVFFNIPQIQYKNPWVQIMLFKNMTPSPFLRFYLESGEQVLVDVETKSNTEIVEHIKKILGKKEETLREEELEKQQRFHPGNFGPRKYCLRECMCEVEGQVPCPGLVPLPKEMTGKYKAALKANT
What are the official names of this protein?
28S ribosomal protein S25, mitochondrial, MRP-S25, S25mt.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mS25 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CTU2_YARLI
Sequence: MSAESTCRRCDGPTAIKTRQANFCQPCFITFIQQKQRKAMEGCKVLFARPGCVLPPAINILVPISFGQSSLALLDMAHAQLEEQAKTYENAAGFTLNAVFIDCSEADPLEKEPNQIISELEKRFAHAKFTCIPLSKAFEGASSVTLKHNRDYTSFVSGISEEPTSVQQLLSCIGTKSAREDIISVLQRHLIIEEAKKQNESLPTTVAWGHNATRLAELTLSLTIKGRGNRIHAQVLEHKNPKDSISGLPEIHPLNDVLSYEIPFYNSFRNVSDLAVDTVSKPSQVTKNLSIDQLMHQYFENIQTNFPSIASTVVRTAAKLDDPNAAKQGLTPCLICASPVDPNQSLAWLTNITVNEPAAPETEEEEELSKKAHMEKSQEKTGDADRHLPVPNLCYGCIITIRDTDSFTFPKRASKQDILDEFTL
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  May also be involved in protein urmylation.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU5M_METSE
Sequence: MYILVLTVPLLGALVSGLFGRKIGEKGAGIFTSGCLIISLSWSLLIFYETTLNFSTTYIKLWRWLDSDLVTAYFGLQFDSLTAVMLIVVTSISTLVHIFSTAYMDGDPHVPRFMSYLSLFTFFMILLVTSDNYPQLFIGWEGVGLCSYLLINFWLTRIEANKAAIKAMLVNRVGDIGFVLAMLAIWDQFGCLDFASVFNIVALAPSDNTTLICLFLFIGAVGKSAQLGLHTWLPDAMEGPTPVSALIHAATMVTAGVFLLIRSSPLLEQAPMALMVVTIVGSLTAFMAATIGLVQNDLKKVIAYSTCSQLGYMVMACGLSQYSISLFHLMNHAFFKALLFLSAGSVIHALADEQDMRKMGGLIRSIPFTYTMIVIGSLSLMGFPYLTGFYSKDLILELAYDQYYLAFAHWLGVFSALLTAAYSLRLIYLTFISNTNAKKEVFSQAHEGSWNLTLPLILLALGSIFVGYLTKEIIWSFQITLSPIIPTSIKLMPVIFSLFGAGTAVVLYHYSSRIFNAPTSPVGLAGYTFLYSAWQFNYIINHFLVQNVWRLGHLITFRVLDKGVLELIGPKGISQFMIRLTQEISNLQSGLVYNYALMIL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MRPD_BACSU
Sequence: MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVISGILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGEKRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESLKYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGMKGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMIWLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDMLIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGKFKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLYPAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE
What is the function of this protein?
Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B. subtilis.  Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB.  MrpA may be the actual Na(+)/H(+) antiporter, although the six other Mrp proteins are all required for Na(+)/H(+) antiport activity and Na(+) resistance.  MrpA is required for initiation of sporulation when external Na(+) concentration increases.  Also transports Li(+) but not K(+), Ca(2+) or Mg(2+).
What are the official names of this protein?
Na(+)/H(+) antiporter subunit D, Mrp complex subunit D, Multiple resistance and pH homeostasis protein D.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYS_TREPA
Sequence: MLDYRFIRENVDAVKENVKVRNVHADVDAIVHLYDQRVKLLAELQELQRARNENAQTMKSSLDALARSACVETGRALKDRIAHSERLLVQISDQLLSATQALPNMTHMCTPHGRSDSDNLEIKRCGVPPCFSFSPRDHVELARLLDIVDFEAGKKVSGIKFYYLKREGVLLEQALIMFGLQFLQERGFVPFLTPDIAREGMVCGLGFNPRGSGSNIYRIEGEHRCLVATAEITLGAYHAGEVLEERSLPRLYAGLSHCFRKEAGAAGQFSRGLYRVHQFTKLEMFAYCTPSDSECLHERLRSLEEEIFTALEIPFRVVEVCAGDLGAPAYRKWDLEAWMPGRQGGSWGEVTSASNCTDYQARRLNVRYKDAEGKKHYVHMLNGTALAISRVLIALLENGQDAEGRVRIPQALVPFCGFEYLYPRVL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CASC3_RAT
Sequence: MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEEYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSPPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNAAGTGRMSTSRNYSRSGGFKEGRTSFRPVEVGGQHGARSGETLKHEANYRSRRLEQTPMRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSEVVSRGSS
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome (By similarity).  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).  Stimulates the ATPase and RNA-helicase activities of EIF4A3.  Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress.  Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons.  May play a role in mRNA transport.  Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.  Binds poly(G) and poly(U) RNA homomer (By similarity).  Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons.  May play a role in mRNA transport.
What are the official names of this protein?
Protein CASC3, Cancer susceptibility candidate gene 3 protein homolog, Metastatic lymph node gene 51 protein homolog, Protein barentsz, Btz.
What is the protein family that this protein belongs to?
Belongs to the CASC3 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Nucleus speckle. Cytoplasm, Stress granule. Cell projection, dendrite. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity). Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (By similarity). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (Probable).
Protein: CSRA_BUCAI
Sequence: MLILTRRVGETLIIGDEITVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKKK
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIVIB_EXIS2
Sequence: MKEQQPARQPKMDATVRSLEDKIPYVREQRRKKANRRLIYVLILIGLLIGVVFYLQSSFSRVATFDVTGTVNVKKEDIIQASRIKVKETHAFNVSEEAVLERIEDVPGIREATMKKTFLHHYEVDVVEEKEIAYAKDKPGARIVLADGTIIPGKSKEELFDAPILTGFTDQSLERLTKELVKIEPKVRSRISEIVANDQTDKGGLKLFMTDGNTVLLSTSAFSNSLNEYVKVISALPKGKTGTITIDGGIYFKPYKGKK
What is the function of this protein?
Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
What are the official names of this protein?
Cell division protein DivIB.
What is the protein family that this protein belongs to?
Belongs to the FtsQ/DivIB family. DivIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: LFTR_SALCH
Sequence: MRLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQHGIFPWFSPGDPILWWSPDPRAVLWPEKFHLSRSMKRFHNASPYRVTLNYAFDRVIDGCANHRDEGTWITRGIEEAYRRLHELGHAHSIEVWRDRELVGGMYGVSQGALFCGESMFSRQENASKTALLVFCAEFTRHGGKLIDCQVLNSHTASLGAIEIPRRDYLDHLAALRQQPLASRFWVPRTLFLPRK
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S404_ARATH
Sequence: MATSKCYYPRPSHRFFTTDQHVTATSDFELDEWDLFNTGSDSSSSFSFSDLTITSGRTGTNRQIHGGSDSGKAASSLPVNVPDWSKILGDESRRQRKISNEEEVDGDEILCGEGTRRVPPHELLANRRMASFSVHEGAGRTLKGRDLSRVRNTIFKIRGIED
What are the official names of this protein?
Protein S40-4, AtS40-4.
What is the protein family that this protein belongs to?
Belongs to the senescence regulator S40 family.
Protein: HPRT_META3
Sequence: MKILERSLKTCPIVQRGEYTYFIHPISDGVPLIKPDLIREITTEIIKIGDLNVDKIITAEAMGIPLATAISLCTDIPYAIIRKREYKLDGEIAVHQETGYSKGELYLNGVNKGDKVIIVDDVLSTGGTIIALIEALRKAGAEIKDIICVIERGDGKKIVKEKTGHTVKTLMKIDVIDGKVVIL
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
What are the official names of this protein?
Hypoxanthine/guanine phosphoribosyltransferase, HGPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_BORGP
Sequence: MERKVFSKDGKEIGTINLDDRVFNIEISHGSIYNAIKNELSNLRVGTSSTKTRSEVRGSSKKPWKQKGTGRARVGTKRNPIWIGGGIALGPKPRDYSYRLPKKVKRLAFKSVLSLRAADENNFKVVENFNIESGKTKDLALIIKNFASFNGKVVILLGNDDQMIKRAGKNIRDLKILSFNKLRVVDLFYAKNLIALESAVNKLNEFYVK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TIG_COXBU
Sequence: MRGNFMSSIEKLGGLKQRLTITVPAEEVDKAYKSRLLKVARTAKIPKFRPGKASPAVVEKLYGKAILQEVGSELIQSSLREAVEEHQLRVAGAPDIKMDKILRGEPFKYVVNFEVYPEITLESLAGETIERTQVEITEEDLDKMLEALRKQYAEWKEMDRPAKADDRVIIDFEGTLDGKPFERGSAKDFQLELGSKRMIAGFEEGIEGMKPGESKALDITFPADYPSEDLAGKAAVFNITLQKVMAPELPVLDEQFAERLGIKEGGLEALRQKVRTNMEKEVHHHMENKLKMAVLDKLIERNPIEVPESLIEAEIDHLQQMTRQQVAMQTHKPDEAKKMELPRDPYREQATKRVKLGLLLAEVVKQHKIKADPEQLRARVEEVAASYQDPEKVISWYYTNKQMLSEIESVVLEDQAVAQLMSELEVKDQAIPYEEAVKQIQQ
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: DNAA_RALPJ
Sequence: MQDFWHAASAQLESELTPQQFKTWIKPLTPLSFDEQACTLRIAAPNRFKLDWVKSQFSGRIQSLACDYWEATVDVQFVLDPSAGQRQAALQPALAPVPMQPLGAQAGQPRQAMPAGNGVSHDAATLRPAPSVYRETALATASHAAADIDVPVMDAAEVSARSYRMPPQAPAVVATLAAPPQAHVDDSVHERSRLNQILTFDNFVTGKANQLARAAAIQVANNPGKSYNPLYLYGGVGLGKTHLIHAIGNFMLMENPRARIRYIHAEQYVSDVVKAYQRKAFDDFKRYYHSLDLLLIDDIQFFSGKNRTQEEFFYAFEALIANRAQVIITSDTYPKEITGIDDRLISRFDSGLTVAIEPPELEMRVAILMKKAQAENVTVPEEVAFFVAKHLRSNVRELEGALRKILAYSNFHGKEITIEVTREALKDLLTVQNRQISVENIQKTCADFYNIKVADMYSKKRPANIARPRQIAMYLAKELTQKSLPEIGELFGGRDHTTVLHAVRKIADERTKDAQLNHELHVLEQTLKG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RDRP_TOMS1
Sequence: MAYTQTATSSALLETIRGNNTLVNDLAKRRLYDTAVDEFNARDRRPKVNFSKVVSEEQTLIATKAYPEFQITFYNTQNAVHSLAGGLRSLELEYLMMQIPYGSLTYDIGGNFASHLFKGRAYVHCCMPNLDVRDIMRHEGQKDSIELYLSRLERGNKHVPNFQKEAFDRYAEMPNEVVCHDTFQTCGHSQECYTGRVYAIALHSIYDIPADEFGAALLRKNVHVCYAAFHFSENLLLEDSHVNLDEINACFQRDGDRLTFSFASESTLNYSHSYSNILKYVCKTYFPASNREVYMKEFLVTRVNTWFCKFSRIDTFLLYKGVAHKGVDSEQFYKAMEDAWHYKKTLAMCNSERILLEDSSSVNYWFPKMRDMVIVPLFDISLETSKRTRKEVLVLKDFVYTVLNHIRTYQAKALTYSNVLSFVESIRSRVIINGVTARSEWDVDKSLLQSLSMTFFLHIKLAVLKDDLLISKFALGPKTVSQHVWDEISLAFGNAFPSIKERLINRKLIKITENALEIRVPDLYVTFHDRLVSEYKMSVDMPVLDIRKKMEETEEMYNALSELSVLKNSDKFDVDVFSQMCQSLEVDPMTAAKVIVAVMSNESGLTLTFEQPTEANVALALQDSEKASDGALVVTSRDVEEPSIKGSMARGELQLAGLSGDVPESSYTRSEEIESLEQFHMATASSLIHKQMCSIVYTGPLKVQQMKNFIDSLVASLSAAVSNLVKILKDTAAIDLETRQKFGVLDVASKRWLVKPSAKNHAWGVVETHARKYHVALLEHDEFGIITCDNWRRVAVSPESVVYSDMAKLRTLRRLLKDGEPHVSSAKVVLVDGVPGCGKTKEILSRVNFEEDLILVPGRQAAEMIRRRANASGIIVATKDNVRTVDSFLMNYGKGARCQFKRLFIDEGLMLHTGCVNFLVEMSLSDIAYVYGDTQQIPYINRVTGFPYPAHFAKLEVDEVETRRTTLRCPADVTHFLNQRYEGHVMCTSSEKKSVSQEMVSGAASINPVSKPLKGKILTFTQSDKEALLSRGYTDVHTVHEVQGETYADVSLVRLTPTPVSIIARDSPHVLVSLSRHTKSLKYYTVVMDPLVSIIRDLERVSSYLLDMYKVDAGTQXQLQVDSVFKNFNLFVATPKTGDISDMQFYYDKCLPGNSTLLNNYDAVTMKLTDISLNVKDCILDMSKSVAAPKDAKPTLIPMVRTAAEMPRQTGLLENLVAMIKRNFNSPELSGVVDIENTASLVVDKFFDSYLLKEKRKPNKNFSLFSRESLNRWIAKQEQVTIGQLADFDFVDLPAVDQYRHMIKAQPKQKLDLSIQTEYPALQTIVYHSKKINAIFGPLFSELTRQLLDSIDSSRFLFFTRKTPAQIEDFFGDLDSHVPMDVLELDVSKYDKSQNEFHCAVEYEIWRRLGLEDFLAEVWKQGHRKTTLKDYTAGIKTCLWYQRKSGDVTTFIGNTVIIASCLASMLPMEKLIKGAFCGDDSLLYFPKGCEYPDIQQAANLMWNFEAKLFKKQYGYFCGRYVIHHDRGCIVYYDPLKLISKLGAKHIKDWDHLEEFRRSLCNVAESLNNCAYYTQLDDAVGEVHKTAPPGSFVYKSLVKYLSDKVLFRSLFLDGSSC
What is the function of this protein?
Is a methyltransferase active in RNA capping and an RNA helicase.  Methyltransferase displays a cytoplasmic capping enzyme activity.  This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus.  Helicase region probably exhibits NTPase and RNA unwinding activities (Potential).  It also acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  May mediate silencing suppression through either inhibition of HEN1-mediated siRNA or siRNA demethylation (By similarity).
What are the official names of this protein?
Replicase large subunit, 183 kDa protein, RNA-directed RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: OXYR_HUMAN
Sequence: MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA
What is the function of this protein?
Receptor for oxytocin.  The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
What are the official names of this protein?
Oxytocin receptor, OT-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RRP42_METAC
Sequence: MKKMSEIIATLKKDYIYNLMIKGKRQDGRGFKDFRDLKLETNVIVKAEGSAKVTLGNTQVLVGVKLQTGTPFPDSQDEGVIITNLELNPIASPEFEPGPPREEAIEMARVVDRGIRESGAIDIKKLCITVGESVWIVFIDVHVLNDDGNIIDASCLAAIAALMTTMVPNEQQGLGEDVPLAMKEMPVGITIAKIGSKLMVDPSLDEEAVCETKLTIVSSSDGSVAGMQKMGISPLTEAELFEAIDLALEKAAELRGLYLEGLAKSE
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Contributes to the structuring of the Rrp41 active site.
What are the official names of this protein?
Exosome complex component Rrp42.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp42 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.