PharMolix/UniProtQA huggingface dataset:
Protein: DCDB_CLOAB
Sequence: MILSGKQIKDSLGKDIVIEPFNEKQINPNSYNLKLHNELLVYDEEVLDMKKPNKTKKLIIPEEGIVLEPRKLYLGRTLEYTETDKYVPMLEGRSSIGRLGVFIHVTAGFGDVGFKGYWTLEIFCVEPIRIYSGVEICQIYYHDVGGDYEKYSSGKYQNNKGIQPSLLYKDFIN
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RNPH_PSEPF
Sequence: MKRPSGRAADQLRSIRITRNYTKHAEGSVLVEFGDTKVICTVSVENGVPRFLKGQGQGWLTAEYGMLPRATGERNQREASRGKQGGRTLEIQRLIGRSLRAALDMSKLGDLTLYVDCDVIQADGGTRTASITGAMVALVDALKVIKKRGGLKGGDPLKQMIGAVSVGMYQGEPVLDLDYLEDSAAETDLNVVMTSTGGFIEVQGTAEGAPFQPEELNAMLELAKKGMNEIFELQKAALAD
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: IBP2_PIG
Sequence: MLPRLGGTALSLLPLLLLLLGTGGRGARAEVLFRCPPCTPESLAACRPPPAAPPSAGAGPAGDSRAPCELVREPGCGCCSVCARLEGERCGVYTPRCAQGLRCYPHPGSELPLQALVLGEGTCEKRRDAEYGASPEQVADNGDDAEGGLVENHVDGNVNLLGGTGGAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQGARGAHTQRMQ
What is the function of this protein?
May have both growth-inhibiting and growth-promoting effects, depending on tissue type; increases IGF-induced DNA synthesis in the uterine epithelium.  IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.  They alter the interaction of IGFs with their cell surface receptors.
What are the official names of this protein?
Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, pIGFBP-2.
What are the subcellular locations of this protein?
Secreted.
Protein: ENGB_THENN
Sequence: MVIKDVKLVKVAKTPGDYPPPLKGEVAFVGRSNVGKSSLLNALFNRKIAYVSKTPGKTRSINFYLVNSRYYFVDLPGYGYAKVSKKERVQWKKLVEDYFTNRWSLQMVFLLVDGRIPPQETDLMMVEWLKSLNVPFTIVLTKMDKVKMSERKKKLDEHKKAFSKYGEYTIIPTSSVTGEGIDDLLNLISTLLKEN
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: VPX_HV2SB
Sequence: MTNPRETIPPGNSGEETIEEAFDWLDRTVEAINREAVNHLPRELIFQVWQRSWRYWHDEQGMSRSYTKYRYLCLMQKAVFMHFKKGCTCRGEGHGPGGWRSGPPPPPPPGLV
What is the function of this protein?
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells.  Targets specific host proteins for degradation by the 26S proteasome.  Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1.  This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1.  In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).
What are the official names of this protein?
Protein Vpx, Viral protein X, X ORF protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus VPX protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.
Protein: SMG8_MOUSE
Sequence: MAGPVSLRELLMGASAWLGSESPGGPSAEGGGNAAGTPEPPWREDEICVVGIFGKTALRLNSEKFSLVNTVCDRQVFPLFHHQDPGDPGTGIKTKAVSVGEAGGAGDPGAAAGDSLRGGMATAEGNRAEPGPQDFSLLQAYYNQESKVLYLILTSICDNSQLLRACRALQSGEAGGGLSLPHAETHEFWKHQEKLQCLSLLYLFSVCHILLLVHPTCSFDITYDRVFRALDGLRQKVLPLLKTAIKDCPVGKDWKLNCRPCPPRLLFLFQLNGALKVEPPRSQDTAHPDKPKKHSPKRRLQHALEDQIYRIFRKSRVLTNQSINCLFTVPANQAFVYIVPGSQEEDPIGMLLDQLRSHCTVKDPESLLVPAPLSGPRRYQAMRQHSRQQLSFHIDSSTSSSSGQLVDFTLREFLWQHVELVLSKKGFDDSVGRNPQPSHFELPTYQKWISAAAKLYEVAIDGKEEDLGSPTGELTSKILSSIKVLEGFLDIDTKFSENRCQKALPMAHSAYQSNLPHNYTMTVHKNQLAQALRVYSQHARGPAFHKYAMQLHEDCYKFWSNGHQLCEERSLTDQHCVHKFHSLPKSGEKPEADRNPPVLYHNSRARSTGACNCGRKQAPRDDPFDIKAANYDFYQLLEEKCCGKLDHINFPVFEPSTPDPAPAKNEPSPAPPDSDAEKLKEKEPQTQGESTSLSLALSLGQSTDSLGTYPADPQAGGDNPEVHGQGEGKSEKRPNLVDRQASTVEYLPGMLHSNCPKGLLPKFSSWSLVKLGPAKSYNFHTGLDQQGFVPGTNYLMPWDIVIRTRAEDEGDLDTNSWPAPNKAIPGKRSAVVMGRGRRRDDIARAFVGFEYEDSRGRRFMCSGPDKVMKVMGSGPKESALKALNSDMPLYILSSSQGRGLKPHYAQLMRLFVVVPDAPLQIILMPQVQPGPPPCPVFYPEKQEITLPPDGLWVLRFPYAYVTERGPCFPPKENVQLMSYKVLRGVLKAVTQ
What is the function of this protein?
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC).  Acts as a regulator of kinase activity (By similarity).
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG8, Protein smg-8 homolog.
What is the protein family that this protein belongs to?
Belongs to the SMG8 family.
Protein: AMPA_PECAS
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKVGQSLLLHHVPNILSERILLIGCGKERELDERQYKQVIQKTINALNETGSMEAVCFLTELHVKGRNTYWKVRQAVETAKETLYTFDQLKSNKVELRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADTYSQNTITRVIGEEQMKELGMNAYLAVGQGSQNESLMSVIEYKGDPNPENRPIVLVGKGLTFDSGGISIKPADSMDEMKYDMCGAATVYGVMRMAAELALPLNIIGVLAGCENMVDGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDTLTYVERYEPDVVIDVATLTGACVIALGHHITGLMANHNPLAHELLSASEQSGDRAWRLPLTDEFQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYSWAHLDIAGTAWRSGKAKGATGRPVALLSQFLLNRAGQNDVE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED4_DICDI
Sequence: MNKRINEVSGRPIGEYLSRDISDFQRVSRTLFECFSSLATGATLNSQQLQQIQLPIDQISNNATPNMVLQLMNHLIDVDKIYQNTLKKLEKHQKIQKEITEIQKEIEEKDKLISTLALNLKDIESFLENELSQDNVNINNGNASDGIVNEVLIDLKQPDDAASMDNIVNREVSPEDLISYAHKISGTTSAPFGYQPNAPLASLFKPPAPQDEMMRSSVLFTKPPPHVLKYYGLAEIDVTTPTMAANISSPFSIGGNVGDVTTPTSKEQEDQQQQQQQQQPQQQLSQSQQSQQQTESELQPIQSILQPPQQLNIDLDLNPDLDSSGDDDDEDDDDEESEEVEWD
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Putative mediator of RNA polymerase II transcription subunit 4, Putative mediator complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COX2_AEDAE
Sequence: MATWANLGLQNSSSPLMEQLNFFHDHTLLILIMITVMIAYIMFMLFFNKFTNRYLLHGQTIEIIWTILPAIILMFIAFPSLRLLYLMDEINSPLITLKVIGHQWYWSYEYSNFLNLEFDSYMIPTNELDLNGFRLLDVDNRIILPMNNQIRILVTATDVLHSWTVPSLGVKIDATPGRLNQTNFLINQPGLFFGQCSEICGANHSFMPIVVESIPMNYFIKWISSQMN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UVRC_ACIAD
Sequence: MNPNARPHIEKILANMTQLPGVYRMLGKDGELLYVGKAKNLKNRVSSYFVKTIEHPKTQALVARIHDIETLVTRSETEALLLEQNLIKQHRPPYNIMLRDDKSYVYIFVSSDKPYPRIASGRGKGKHQIGKFFGPYPSAYSARDTLLVLQKLFNVRQCENSYFAQRKRPCLQYQIKRCSAPCVGLISPEDYKQDVDNSIRFLQGDTKELNQELIAKMEEAAEQLAFEKAMFYRDRLGLLREVQAQQAVFKIKGEADILAIAFQAGVTCVQIMYVRNGRMLGGKSYFPDMLSDDLGQMLSDFIANFYFQVADEVPSELIVNVELPDRKELEQALQTQFDKKIQIKHKVRETRAEWQELAIMNVQHAIKGQLSNHLELNERFHQLEQVVGRPVDRIECFDISHTMGEATIASCVVFDQGGARKRDYRQFGIEDITAGDDYAAMRQALTRRYKKHIVPDLLLIDGGKGQLHMAMEVMQTLGLDAFMVGVSKGEGRKPGLETLHFTDGSKIQLPEDHKALHLIQQVRDEAHRFAITKHRAKRDKRRAGSVLEVIPGLGPKRRRDLLTHFGGIQGVLKASEKELMLVSGLGPSMARTIYKILHE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_FRATW
Sequence: MSKVCIVTGKRPATGNNVSHAQNKTKRRFLPNLHAHRFWVESENRYIKLRVSSKGMRIIDKKGIDTVLSDLRAQGHKI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: URED1_BRASO
Sequence: MRADPASAAADIFEANRARGAVRFDLRLQDGVTRRHHLHESGSLRVRFPSPEDDGLSAMFVNTAGGIAGGDRFAIEVAAGEGSRVTLSSAAAEKVYRAPGTPAELAIALRAADSAHISWLPQETILFDRARIHRRMDIDLAETASLLLCEIVVFGRTAMGERMREGEFVDRWRLRRGGKLVFAETVRLDGDIGDKLAQPAIANGATAIGTALIVPGDGALVERIRESLPASRGEAGLSAWNGFAMARFCAQDAASLRADMMAVLGCASAVPLPRLWLN
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD 1.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_PHOV8
Sequence: MIKAGIIGGAGYTAGELIRLLINHPDVDIKFINSSSNAGNKITDVHEGLYGETDLVFTDELPLDEIDVLFFCTAHGDTKKFMDSHNVPEDLKIIDLSMDYRIKSDDHDFIYGLPELNRRAICHSKHVANPGCFATCIQLGLLPLAKHLLLNEDIMVNAITGSTGAGVKPGATSHFSWRNNNMSIYKPFSHQHVPEIKQSLKQLQNSFNAEIDFIPYRGDFPRGIFATLVVKCKVELEELVKMYQDYYAEDSFVHIVDKNIDLKQVVNTNKCLIHLEKHGDKLLVISCIDNLLKGASGQAVHNMNLMFNLEETVGLRLKPSAF
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXJ_PSEA7
Sequence: MTEATRILLGVNIDHVATLRQARGTRYPDPVKAALDAEEAGADGITVHLREDRRHIQERDVRMLKEVLQTRMNFEMGVTEEMLAFAEEIRPAHSCLVPERREELTTEGGLDVAGQEQRIRDAVRRLAAVGSEVSLFIDPDPRQIEASARVGAPAIELHTGRYADAENPGEQARELQRVREGVALGRSLGLIVNAGHGLHYHNVEPVAAIEGINELNIGHAIVAHALFVGFRQAVAEMKALMLAAAAKR
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABHD5_MOUSE
Sequence: MKAMAAEEEVDSADAGGGSGWLTGWLPTWCPTSTSHLKEAEEKMLKCVPCTYKKEPVRISNGNRIWTLMFSHNISSKTPLVLLHGFGGGLGLWALNFEDLSTDRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALRLDKMILLGHNLGGFLAAAYSLKYPSRVSHLILVEPWGFPERPDLADQERPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGGLHPDIPVSVIFGARSCIDGNSGTSIQSLRPKSYVKTIAILGAGHYVYADQPEEFNQKVKEICHTVD
What is the function of this protein?
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid (PubMed:19801371).  Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor (PubMed:19801371).  Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (PubMed:19801371).  Functions in phosphatidic acid biosynthesis (By similarity).  May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289).  Involved in keratinocyte differentiation (By similarity).  Regulates lipid droplet fusion (PubMed:26083785).
What are the official names of this protein?
1-acylglycerol-3-phosphate O-acyltransferase ABHD5, Abhydrolase domain-containing protein 5, Lipid droplet-binding protein CGI-58, Protein CGI-58.
What is the protein family that this protein belongs to?
Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Lipid droplet. Cytoplasm, cytosol. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA.
Protein: COAD_FLAJ1
Sequence: MRKAIFPGSFDPITLGHEDIIKRGIPLFDEIVIAIGVNAEKKYMFSLEERKRFIEETFKDEPKVSVITYEGLTIDLAKKQKAHFILRGLRNPADFEFEKAIAHTNRKLSKIETVFLLTAASTSFISSSIVRDVLRHGGEYEMLVPDAVRVKK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECX_STRP1
Sequence: MKITKIEKKKRLYLIELDNDESLYVTEDTIVRFMLSKDKVLDNDQLEDMKHFAQLSYGKNLALYFLSFQQRSNKQVADYLRKHEIEEHIIADIITQLQEEQWIDDTKLADTYIRQNQLNGDKGPQVLKQKLLQKGIASHDIDPILSQTDFSQLAQKVSQKLFDKYQEKLPPKALKDKITQALLTKGFSYDLAKHSLNHLNFDQDNQEIEDLLDKELDKQYRKLSRKYDGYTLKQKLYQALYRKGYNSDDINCKLRNYL
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDB_CLOPE
Sequence: MGLKIIYGRAGTGKSTFCINQIKKKINNSPNNKLILLVPEQFTFQTENKVLSAIGERYVLNAEVLSFKRLAHNVFNECGGATRTIMGDAGKSMLIFKVLEDLGDNMTVFKNASRQKGFIDIASKTITEFKKYNVNNEVLDLTINEIEDENLKMKMEELKDVFNEFNSRLHEGYVDEEDQLLLLNEKLDGCSLYDGAEIWIDEFSSFTPNQLSVIGKLLKRAKSVNITLSIDEVNSLKGESDLFVATKNTEKRLMNLIQEEGIAFSGYINLNEDIPYRFKENKELAHIERQLYAYPFKQYRGKNNSLRLYRANNNYDEIEFVAKDILRLVREKQYRFKDISVICRDVDNYEKVVSAIFSEYEIPYYIDKKIDIASNPLIVFINSAVDIISKNWTYESMFKYLKTGLIKEFRGIEGAELIDELENYVLAYGIKGKKWMEEWVNYSSSILKEEEISEENKQRLERLNDIRETIVTPLDEFNKQCKGKKTLKEFATILYEFLDSKLDIMDTLDKYVDYFKENDMAIEAKEYSEVRDIFIDVLEQAVDVLGNEVMDLNEFMKVLNIGLSQYEMGLIPVALDQVNIGDITRIKSRGTKALYIIGVNDGVLPSASKEEGILSDNDREILLEKGISLASDTRTKIFEEQFLVYTAFTIAEEYLVVTYPLADFEGKSQRPSIIVHRLKKILPNVKEESEGFKLVDDKYEKISAKIPTLNELMIAIRKNYDGAEIEDYWKYVYDWYLREPKWKERIEYVRKGLEYTNLENNISKEKAKKLYEDNKNKISLSVSRLERYAQCPFAYYIQYGLKAKDRKIYEFTAPDLGSFMHEILDEFTNEIKEKDLKWSDLSKENCRNIINSLVDNQVKNNKSSILNSSKRYSYFTDRFKRILTKSVMVISEQMKRSDFEIYKNELAFGFSKDVNSIKLDLPSGESFYLNGRIDRVDKLNLDGETYLRIIDYKTGSKKFDLNKFYNGLQMQLLVYLDALINNSENIVENQAMPGAILYFRIDDPILKSKGDLTEEEIKSEVLKELKLEGLLLDDVKVVKAMDNTLEPGTHSLIIPANMKKAGDLGKNKALITMEQFELLRKYVNEKMVEICQNMIEGKIDIEPCKENKNIVCDYCNYSHICQFDSSLEDNRYKVIPKKKDEDIWKSINEKVGGEVNGD
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: PSRP_XANC8
Sequence: MSTIRPVFYVSDGTGITAETIGHSLLTQFSGFNFVTDRMSFIDDADKARDAALRVRAAGERYQVRPVVVNSCVDPQLSMILAESGALMLDVFAPFIEPLERELNAPRHSRVGRAHGMVDFETYHRRINAMNFALSHDDGIALNYDEADVILVAVSRAGKTPTCIYLALHYGIRAANYPLTEEDLESERLPPRLRNYRSKLFGLTIDPERLQQIRQERRANSRYSAAETCRREVATAERMFQMERIPTLSTTNTSIEEISSKVLSTLGLQREMF
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: IFT56_TRYB2
Sequence: MLSTSGRVKRKNAAPLQKVGQTKTSVVDQLEEALQQRDFSKATTVLEFYKTTNQPVGDLPINPWLAYSAFHMNDVSKALDVYKELLSLDGCDPMHYIHMGCCHFVNGSYAEAEECALKGPDCSLQTRLLFHIAQKTYDEDKLLVYHQKLKETVEDQLSLGAVHFYRGHFQEAIDVYKRILLETREYIALNVYVAMCYYKMDYYDVSLEVLNVYLQSHNNSATAINLKSCNHYRLYNGKAAEAELRVLIDLQRSTYNVENDIVKHNLVVFRNGEDALQVLPPLLNVVPEARLNLVIYHLRHEQIEEAYELIKDLEPVASTEYILKAVVNAFIGQKLDSEEHLKTTREYFNLIGSAQSECDTIPGRQCMASYFFILRDFPNVLIYLRSIKPYFLNDDTFLYLHGIACAATGSFAEAEESLTAVRSEKVKAEFSYMSWLMRAHIMNKHAKRAWDIYLKMETSAESFNILQLMANDCYKVCAFYYAAKAFDVLERLDSAPEYIEGKKGACIGVFQQVFAGQEPADSLFDVMKMLDMSVQQHANDPKVSQQFESILKVIKDWVKESKLKKK
What is the function of this protein?
Component of the intraflagellar transport (IFT) complex required for transport of proteins in the motile cilium.
What are the official names of this protein?
Intraflagellar transport protein 56 homolog, Putative IFT protein C3.
What is the protein family that this protein belongs to?
Belongs to the IFT56 family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum. Note=Localizes around the basal bodies and the flagellum base.
Protein: PHS_RHOPB
Sequence: MVKRLTDEDRHAALRELPGWSAAEGREAIARTFVFKDFNEAFGFMARVALIAEKHDHHPEWRNVYKTVEVVLTTHDAGGVTARDIDLARAMNAIAAQLSPR
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: TNR8_RAT
Sequence: MSILLKAAGLLFLGMLQAFPKDRPLDTTCTGDLSYYPGEAARNCCYQCPSGLSPTQPCPQGPATARSSVILTTTNEDRKCTACVTCLPGLVEKAPCSGNSPRICECQPGMYCSTPAVNSCARCSEKTVVKFPDTAEKNTICDLPSPGSGPNGSNPDDCKTLTSHTTPQAIPTLESPANDSVRSLLPKQVTDFVNEGATKLVKVPESSSSKASMPSPDPGNAEMNMTLKLPPPGTVPDISTSENSMEPASTASTLSLLVDARTSSRMQPTSPLSTGTPFLDPGSMLFWVAMVVLLVGSASFLLCYWKACRRRFQRKFHLNYLQQTFQPKMEQVDSCPTEKLTQLQRSGSVTDSSAGHTLSPLSPPAVETGASVGTACLETLPLLDDSITGNSFAPREPPEPRVSTEHTNNRIEKIYIMKADTVIVGSVKTEVPEGRAPVGSTESELEAELEVDHTPHYPEQETEPPLGSCTEVMFSVEEGGKEDHEPTTVSEK
What is the function of this protein?
Receptor for TNFSF8/CD30L.  May play a role in the regulation of cellular growth and transformation of activated lymphoblasts (By similarity).  Regulates gene expression through activation of NF-kappa-B (PubMed:8982082).
What are the official names of this protein?
Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Lymphocyte activation antigen CD30.
What is the protein family that this protein belongs to?
Belongs to the TNFR8 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: MSRA_SALDC
Sequence: MSLFDKKHLVTQADALPGRNTPMPIATLHAVNEHSMTNVPAGMEIAYFAMGCFWGVERLFWQLPGVYSTAAGYAGGYTPNPTYREVCSGQTGHAEAVRIVYDPAVIRYEQLLQTFWENHDPTQGMQQGNDHGTQYRSAIYPLTPEQNAAAHASRERFQSAMAAAGDHRPITTEIAHATPFYYAEDEHQQYLHKNPYGYCGIGGIGVCLPPDA
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: GPSB_STAAB
Sequence: MSDVSLKLSAKDIYEKDFEKTMARGYRREEVDAFLDDIIADYQKMADMNNEVVKLSEENHKLKKELEELRLRVATSRPQDNKSFSSNNTTTNTSSNNVDILKRISNLEKAVFGK
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.