PharMolix/UniProtQA huggingface dataset:
Protein: RP132_CWPXB
Sequence: MKKNTDSEMDQRLGYKFLVPDPKAGVFYRPLHFQYVSYSNFILHRLHEILTVKRPLLSFKNNTERIMIEISNVKVTPPDYSPIIASIKGKSYDALATFTVNIFKEVMTKEGISITKISSYEGKDSHLIKIPLLIGYGNKNPLDTAKYLVPNVIGGVFINKQSVEKVGINLVEKITTWPKFRVVKPNSFTFSFSSVSPPNVLPTRYRHYKISLDISQLEASNISSTKTFITVNIVLLSQYLSRVSLEFIRRSLSYDMPPEVVYLVNAIIDSAKRLTESITDFNIDTYINDLVEAEHIKQKSQLTINEFKYEMLHNFLPHMNYTPDQLKGFYMISLLRKFLYCIYHTSRYPDRDSMVCHRILTYGKYFETLAHDELENYIGNIRNDIMNNHKNRGTYAVNIHVLTTPGLNHAFSSLLSGKFKKSDGSYRTHPHYSWMQNISIPRSVGFYPDQVKISKMFSVRKYHPSQYLYFCSSDVPERGPQVGLVSQLSVLSSITNILTSEYLDLEKKICEYIRSYYKDDISYFETGFPITIENALVASLNPNMICDFVTDFRRRKRMGFFGNLEVGITLVRDHMNEIRINIGAGRLVRPFLVVDNGELMMDVCPELESRLDDMTFSDIQKEFPHVIEMVDIEQFTFSNVCESVQKFRMMSKDERKQYDLCDFPAEFRDGYVASSLVGINHNSGPRAILGCAQAKQAISCLSSDIRNKIDNGIHLMYPERPIVISKALETSKIAANCFGQHVTIALMSYKGINQEDGIIIKKQFIQRGGLDIVTAKKHQVEIPLENFNNKERDRSNAYSKLESNGLVRLNAFLESGDAMARNISSRTLEDDFARDNQISFDVSEKYTDMYKSRVERVQVELTDKVKVRVLTMKERRPILGDKFTTRTSQKGTVAYIADETELPYDENGITPDVIINSTSIFSRKTISMLIEVILTAAYSAKPYNNKGENRPVCFPSSNETSIDTYMQFAKQCYEHSNPKLSDEELSDKIFCEKILYDPETDKPYASKVFFGPIYYLRLRHLTQDKATVRCRGKKTKLIRQANEGRKRGGGIKFGEMERDCLIAHGAANTITEVLKDSEEDYQDVYVCENCGDIAAQIKGINTCLRCSKLNLSPLLTKIDTTHVSKVFLTQMNARGVKVKLDFERRPPSFYKPLDKVDLKPSFLA
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of D6 and A7, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase 132 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity).
Protein: NACC1_HUMAN
Sequence: MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNNSRSAVVELPAAVQPQSFQQILSFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHAEEAPSSEPQSPVAQTSGWPACSTPLPLVSRVKTEQQESDSVQCMPVAKRLWDSGQKEAGGGGNGSRKMAKFSTPDLAANRPHQPPPPQQAPVVAAAQPAVAAGAGQPAGGVAAAGGVVSGPSTSERTSPGTSSAYTSDSPGSYHNEEDEEEDGGEEGMDEQYRQICNMYTMYSMMNVGQTAEKVEALPEQVAPESRNRIRVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMCTNARRVVRKSWMPKVKVLKAEDDAYTTFISETGKIEPDMMGVEHGFETASHEGEAGPSAEALQ
What is the function of this protein?
Functions as a transcriptional repressor.  Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4.  Contributes to tumor progression, and tumor cell proliferation and survival.  This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1.  Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
What are the official names of this protein?
Nucleus accumbens-associated protein 1, NAC-1, BTB/POZ domain-containing protein 14B.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation.
Protein: MOAA_ACIC1
Sequence: MTQPIRDSLGRPLRDLRISVTDRCNMRCRYCMPREIFGPNFTFLPRSELLTFEEITRIAAAFIRAGVRKIRLTGGEPLLRADLPRLVAMLADLPDVHDLALTTNGSLLARYARPLRDAGLRRVTVSLDTLNPATFSRLADTDIPLDNVLAGIDAAQSAGFFPIKLNAVIRRGVNDGDVEELAAFARDNGHIMRFIEYMDVGNSNGWRAADVVPAAEIIARISSHWPIDPLPPRYPGEVANRFRYRDGRGEFGVIASITQPFCRDCTRLRLSAVGEVFTCLFAVRGHDLRSIVRSNTDSAAIDAALDEAITRIWSRRSDRYSELRALDSDGSREDADESEASAVPGRSTHPGHRKVEMSYIGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: Y1313_STRP4
Sequence: MSNIYDSANELSRGLRGLPEYKAVKAAKDAIAADAEASKIFTEYLAFQEEIQKLAQTGQMPDASFQAKMEGFGKQIQGNSLLSEFFTKQQQLAIYLSDIEKIVFEPVSELLK
What are the official names of this protein?
UPF0342 protein SPG_1313.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: PATR_MYCBO
Sequence: MTARLRPELAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIDRATDTVNRYPDNGCVQLKAALARHLGPDFAPEHVAVGCGSVSLCQQLVQVTASVGDEVVFGWRSFELYPPQVRVAGAIPIQVPLTDHTFDLYAMLAAVTDRTRLIFVCNPNNPTSTVVGPDALARFVEAVPAHILIAIDEAYVEYIRDGMRPDSLGLVRAHNNVVVLRTFSKAYGLAGLRIGYAIGHPDVITALDKVYVPFTVSSIGQAAAIASLDAADELLARTDTVVAERARVSAELRAAGFTLPPSQANFVWLPLGSRTQDFVEQAADARIVVRPYGTDGVRVTVAAPEENDAFLRFARRWRSDQ
What is the function of this protein?
May catalyze the transamination reaction in phenylalanine biosynthesis.
What are the official names of this protein?
Putative phenylalanine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: SEY1_YEAS6
Sequence: MADRSAIQLIDEEKEFHQSALQYFQQCIGNRDVGLDYHVISVFGSQSSGKSTLLNVLFNTNFDTMDAQVKRQQTTKGIWLAHTKQVNTTIEIDNDRPDIFVLDVEGSDGSERGEDQDFERKAALFAIAVSEVLIVNMWEQQIGLYQGNNMALLKTVFEVNLSLFGKNDNDHKVLLLFVIRDHVGVTPLSSLSDSVTRELEKIWTELSKPAGCEGSSLYDYFDLKFVGLAHKLLQEDKFTQDVKKLGDSFVMKGTENYYFKPQYHHRLPLDGWTMYAENCWDQIERNKDLDLPTQQILVARFKTEEISNEALEEFISKYDESIAPLKGNLGSLTSQLVKLKEECLTKYDEQASRYARNVYMEKREALNTKLNSHISGTINEFLESLMEKLWDDLKLEVSSRDKATTSFVESVAAGKSKIEKEFNESMETFKKLGLLISNEEITCKFSDDIEERIKQLRDAELKAKIGRIKKNLVPELKDHVIHLLSHPSKKVWDDIMNDFESTIKDNISAYQVEKDKYDFKIGLSESENAKIYKNIRILAWRTLDTTVHDYLKIDTIVSILRDRFEDVFRYDAEGSPRLWKTEEEIDGAFRVAKEHALEVFEVLSLAVTSDNVEIIPDVPMAEEESGEDNEIYRDNEGVFHSRRFAHILTELQKENVLDQFRRQINITVLDSKRSIITTRTHIPPWIYVLLAVLGWNEFVAVIRNPLFVTLTLILGATFFVIHKFGLWGPVVNVVQSAVGETRTAIKDKLRQFVVEDHEVKESFEMKDFSKNEQKEK
What is the function of this protein?
Cooperates with the reticulon proteins RTN1 and RTN2 and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network.  Has GTPase activity, which is required for its function in ER organization.
What are the official names of this protein?
Protein SEY1, Synthetic enhancer of YOP1 protein.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Enriched in the cortical ER. Concentrated in punctae along the ER tubules.
Protein: SUCC_PROA2
Sequence: MNIHEYQGKDILRKFGVSVPKGIVAFTAEEARQAAEQLFEEQENPVVVVKAQIHAGGRGKAGGVKLAKSPDEVFDIARQMIGCTLVTHQTGPEGKEVRRLLVEEGMNIEKEFYVGITLDRATSQNVLMVSTEGGMEIETVAEETPEKLLKIQIHPLQGLQGFQARQAAFFLGLEGDKFKNTVKFITALYKAYTAIDASIAEINPLVITKEGKVMALDAKINFDSNALFRHKDFLELRDISEEDPFEVEASKSNLNYVRLDGNVGCMVNGAGLAMATMDMIQLAGGKPANFLDVGGSASPETVEEGFKIIMSDKNVKAILINIFGGIVRCDRVAGGVIEAAKKVGLDMPVIVRLEGTNAEIAQKMLDESGLNLIAANGLREAAQKVNEALS
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RS7_NATTJ
Sequence: MSRKGPAPKRDVNPDPIYNSKMVTKFINKLMLDGKKGLSQRIFYKALELVGERTNEEPLEVFETAVKNVMPVLEVKARRVGGATYQVPVEVEPNRKQVLAIRWIVNYARERGERAMSERLAGELIDAYNNTGGAIKKKEDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RS20_STAAR
Sequence: MANIKSAIKRVKTTEKAEARNISQKSAMRTAVKNAKTAVSNNADNKNELVSLAVKLVDKAAQSNLIHSNKADRIKSQLMTANK
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RS3_DEHM1
Sequence: MGRKVHPIGFRLGIIKDWSAKWHASDKGFAECLTEDLKLRKAIAKKYVDAAISQVDIERQSNKVTVSVRTARPGIVIGRGGQRVDEMRHFLEELIGKKVQLNIVEISQAELDAFLVARSVAEQIERRVAYRRAMKQAIFRSMQAGAKGIKVCASGRLGGVEIARREVMHEGRVPLHTLRADIDYGCTRAHTALGDIGIKVWVYRGDILPEAKEQSEPEVTEMAAVMADAPAAAVAEAKVADTVAKPKRVTKKAEAEASAEEKPKRAAKKAENITKEEE
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: KTHY_RUEPO
Sequence: MSGTGLFLTFEGIDGSGKSTQARLLAETLRAAGHDVVLTREPGGSPGAEEIRRLVLEGDPDRWSAETEILLFTAARRDHLERTIEPALAAGRVVICDRFADSTRMYQGLSRGDLRQLVDQLHALMIGREPDLTLLVDMDPETGLSRAKGRQGSEERFEDFGPELQQRMRAGFLDLAREYAHRFRIIDGNRDMDSVAADVTEIVLTHLNRTR
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: ARGR_COREF
Sequence: MTMDDGRASTSTPVTRTARQALIVQILNRQRVTSQVQLSELLLDEGIDITQATLSRDLDELGARKVRPDRGRAFYAIGPVDTTIGEDLRGPQEKLRRMLDELLVSTDHSGNIAMLRTPPGAAQYLASFIDRVGLKEVVGTIAGDDTVFVLAREPLTGRDLGELLGGRAGARGPEGKV
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_MESFL
Sequence: MAVPFRKTSKSAKNKRRSHLALVASNLVSCENCGSMIKPHRVCRECGFYKGKEVKSVQD
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: GDE1_CANAL
Sequence: MKFGKTYVTHQIPEWSIYYMNYKQLKKIIKSIDSAANTNVDESKYPEVISDTLGSFFYDLDRDIEKVDSFYNTKFKEYNRRLNKIFQVLGYQDGQITHNIESSEELDEIINILIELKSLFRNLKWFAELNHKGFIKILKKLDKKLTSILSQHSGVSVGGVSNHNQEAYMGSRINALPFANGTEASNCLDSIHHILSRIETRNDVVQETIPVENNETSISALIKNDDFEGLKKHITIKSSQKFLISTLNKAALANSTKCIDVIWNQLDMLYDDSDFNGRNFFHQHIISLGKAQFIREEQIVPGEVTNRLIGGDNGPDNSNKNDNPIGLLYILNKLKHKRLILAEDHYHRTPLHYASQYGLVEVTRYLVEFGVKWGLINTSISIDDVSIWGDQEGLTPLHLSIIGKHPKTTETLLGFNKAQTLTCPNLLLLAVRLNSPQILNSLIVEGNIDVNYTDIDHRNETALYIASKLNHPDLVEFLLESNANTEIGENVFGWTPIFIAASEGFMTIVKLLKEYGASYDIVDDSGWLPMEHACLRGHLDVTDLLLPKNEKLLLYDMYHPENNLPRIPSLAASPVLTGSDDGTVSTSSIDKLPEPQKNTVNQFYKQLKNNSSNNVSRSTSPKRNKRYKPVKSFGHRYLNEDESLILLTLGTTDLRDTNVPVELNKVSLAKSFATELDTALSLSITCRHKLTNNPVEPPVVVDLPLEDFHGSATDPISFKLSNDLTVNDVIITFDIIPTYQVNKKVIGRAIALLKDAYTKVGPNLRSLNNSIAIPIIESTNLDILGTIRFEYLQVLPFKHKAMSIARSDTYWKQLVSTRVIGHRGLGKNLSGKKSLQLGENTVESFIAAASLGASYVEFDVQLTKDHVPVVYHDFTVAESGVDIPMHLLTLEQFMGFNTPTEKPTHTVDDEVLTRGKQRAQSSYQLSNNHNDDIEKEFANQRDERMKFTKTWKNQGYKGNLRGSSVASNFVTLRELFRKLPNNVGFNIEVKYPMLDEAQLEDMGEIGVDLNFFVDTILKVIYDENTTGRDIVFSSFHPDICLLLSLKQPTMPVLFLTEAGTAPMYDIRASSLQNAVRFSKKWNLLGIVSNALALIKTPRLAQVVKSMGLVCVTYGTENNEPELAKIQMRAGVDAVIVDSVLAVREGLREHNETMNEFEDSPTE
What is the function of this protein?
Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline (PubMed:24114876).  The choline is used for phosphatidyl-choline synthesis (PubMed:24114876).  Required for utilization of glycerophosphocholine as phosphate source (PubMed:24114876).  C. albicans can utilize GroPCho through transport and intracellular hydrolysis or through extracellular hydrolysis (PubMed:24114876).
What are the official names of this protein?
Glycerophosphocholine phosphodiesterase GDE1, Glycerophosphodiester phosphodiesterase GDE1.
What is the protein family that this protein belongs to?
Belongs to the GDE1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBT_NICTO
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPKVPTKKN
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RNM5_MESFL
Sequence: MANEIIIVEGKSDSQKLKKIYGENLITFETNGLGIDDKKLNSIKELSKKNKIIIFTDPDGPGKKIRETIIEFLDVDVFNAFVSKQDIDKNSKKIGLAEASEEAIKKALDNLITYNKKNISISWDEYVKNDFYIKANRIIIANHFNLSEDMSSKSLFKWLNWMNLKVKDIEKIIGE
What is the function of this protein?
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor.  Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.
What are the official names of this protein?
Ribonuclease M5, RNase M5, Ribosomal RNA terminal maturase M5.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease M5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHS3_IPOBA
Sequence: MVTVGEVRKAQRAEGPATILAIGTATPANCVNQSTYPDYYFRITNSEHKTELKEKFQRMCDKSMITKRYMHLTEEILKENPSFCEYMAPSLDARQDIAVVEVPKLGKEAAQSAIKGWGQPKSKITHVVFCTTSGVDMPGADYQLTKLLGLRPSVKRLMMYQQGCFAGGTVLRLAKDLAENNKGARVLIVCSEITVVTFRGPSEAHLDSLVGQALFGDGAAAVIVGADPTPAEKPLFQLVSAAQTLAPDSCGAIDGHLREVGLTFHLLKDVPSVVSNNIEKCLFEAFNPLGISDWNSVFWIAHPGGPAILDQVEDKLGLKPEKLRATRHVLSEYGNMSSACVLFILDEMRKASSNDGLGTTGEGLEWGVLFGFGPGLTIETVVLHSVPT
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase LF3, Naringenin-chalcone synthase LF3.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: RIMP_ACIF2
Sequence: MEDRLYEGIAQQAGIAGCTLVDARMVRTGRAVALQVFIEKDETTAVTIEDCAAVSRQLSLWLDVENPIHGAYRLEVSSPGLDRPLKNLHDFERFKGSQAEIHLHGLTQGRRRLQGELLGVEDQKIVLKNAEGRWTFALDDIHKARLVPQW
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y785_CUPMC
Sequence: MAGHSKWANIKHKKAAADAKRGKVWTRLIKEITVAAKLGGGEFDSNPRLRLAMEKAMDANMPKDNIQRAIQRGVGGLEGANYEEIRYEGYGLAGAAIIVDCLTDNRTRTVAEVRHAFSKHGGNMGTEGSVAFMFTHCGQFLFAPGTPEDKLMDAALEAGADDVVTNDDESIEVTCPPNDFGAVKAALEAAGFKAEVADVVMKPQNEVSFVGDDAVKMQKLLDALENLDDVQEVFTNAVVEE
What are the official names of this protein?
Probable transcriptional regulatory protein Rmet_0785.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_NEIG1
Sequence: MKQGIHPNYREVNVTCSCGNKFVTKSAMEKENFNIEVCSLCHPFYTGTQKIVDTTGRVDKFNNKFGNLFKR
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: GPAT3_CHICK
Sequence: MEELGSLAVWLGAAWLSLVFALIVLPSALGVSLGISEAYMWVLVKTLEWATIRIEKGVKKPQPQMLKIPAANGIIERDETPMEKEIAGLHRMEFRFSDIFYFCRKGFEAIVEDEVTQRFSSEELVSWNLLTRTNVNFHYVSLRLTVVWVIGVIVRYCFLLPLRFTLAAIGITSMIVGTTVVGQLPNGSLKNYLSEVVHLTCSRILVRALSGTIHYHNKENKPQKGGICVANHTSPIDAIILTNDGCYAMVGQVHGGLMGVIQRATVKACPHVWFERSEIKDRHLVTKRLREHVADKNKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIYPVAIKYDPQFGDAFWNSSKYNIVSYLLRIMTSWAIVCHVWYMPPMVRKEGEDAVQFANRVRSAIARQGGLTELPWDGGLKRAKVKDSFKEEQQKNYSKMLVRNGSQGNLPAGTESD
What is the function of this protein?
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone.  Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.  Protects cells against lipotoxicity.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase 3, GPAT-3, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10, AGPAT 10, 1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9, 1-AGP acyltransferase 9, 1-AGPAT 9, Lysophosphatidic acid acyltransferase theta, LPAAT-theta.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RSEP_ECOLI
Sequence: MLSFLWDLASFIVALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDKLGTEYVIALIPLGGYVKMLDERAEPVVPELRHHAFNNKSVGQRAAIIAAGPVANFIFAIFAYWLVFIIGVPGVRPVVGEIAANSIAAEAQIAPGTELKAVDGIETPDWDAVRLQLVDKIGDESTTITVAPFGSDQRRDVKLDLRHWAFEPDKEDPVSSLGIRPRGPQIEPVLENVQPNSAASKAGLQAGDRIVKVDGQPLTQWVTFVMLVRDNPGKSLALEIERQGSPLSLTLIPESKPGNGKAIGFVGIEPKVIPLPDEYKVVRQYGPFNAIVEATDKTWQLMKLTVSMLGKLITGDVKLNNLSGPISIAKGAGMTAELGVVYYLPFLALISVNLGIINLFPLPVLDGGHLLFLAIEKIKGGPVSERVQDFCYRIGSILLVLLMGLALFNDFSRL
What is the function of this protein?
A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA.  Part of a regulated intramembrane proteolysis (RIP) cascade.  Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue 'Val-148' of RseA may be required for this.  This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA.  Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamase, OmpF, LivK, SecM, PhoA, LivJ, OmpC, Lpp and TorA, probably within the membrane.
What are the official names of this protein?
Regulator of sigma-E protease RseP, S2P endopeptidase, Site-2 protease RseP, S2P protease RseP, Site-2-type intramembrane protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBIC_BURL3
Sequence: MRFDGGQAGWRETPRPGCTLDQRDWLTRGGSLTAHLARLGRVNVRVTREAVDCPWFDEPDAVASAPRAPMWVREVILSVDGTPYVAAHSIAPLAASKGVWQAMRRLRTRPLAELLYSDPQVERSALVSRRVIAGHPLYALATHALGGARAPHSFAARRSVFQRHGKPLMVTECMLPALWRHLDAHGDGPRSGGPGGGA
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYI_METCA
Sequence: MDYKSTLNLPQTPFPMKANLAQREPEQIERWRTLDLYRKVRSRRAGRDKFILHDGPPYANGEIHIGHAVNKILKDFIVKSRTLSGFDAPYVPGWDCHGLPIELMVEKKIGKAGHKVSPAEFRKACREYAAAQVDLQRREFIRLGVLGDWENPYLTMDFRFEADIVRALGRIAARGHLAKGAKPVHWCLDCGSALAEAEVEYENKHSPAIDVRFAVVDEFGLMARFHTADGALGEGPLSVVIWTTTPWTLPANQAVALNPELDYVVVQRTDIKERLVLADALMKDVMLRCGAEGYRVIGYCKGAALEGVQLRHPFYDRIVPVILGDHVTLDAGTGAVHTAPGHGQEDYAVGQRYGLAVDNPVGGDGRFLPNTELFAGEHVLSANDHVIEVLKERGALLHEARIEHSYPHCWRHKTPVIFRATPQWFIAMDKGELRRQALEAIGQVQWIPDWGQARIEAMVGNRPDWCISRQRTWGVPIPLFVHKETGALHPDTDRLIEEIAKKIETAGIDAWFELDPAELLGAEADRYGKIGDTLDVWFDSGVTHHAVLAQNPDLAFPADLYLEGSDQHRGWFQSSLMTSVAMSGQAPYKAVLTHGFTVDAEGKKMSKSRGNVVAPQKVMQTLGADVLRLWVAATDYRGEMTVSDEILKRISDVYRRIRNTARYLLANLDGFDPALHLVKPEDMLALDRWVVDRALAIQQEVIEAYETYQFNTIFQKTHHFCSVDLGSFYLDVLKDRQYTCKTDSLPRRSGQTAMYHIAEAMVRWLAPVLSFTAEEIWQYLPGQREESVFLSEWYDGLFGLDENSRCDRAFWDQMLKIREAVSKELEILRVRGEIGASLDAEVELFCDPPLFRKLSEAGDELRFVLLTSYATVKPAAEAGTDALPTEIPGLELKLAASGKPKCVRCWHHRHDVGTHPDHPELCGRCVDNVAGTGELRTFG
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE1_PAPVE
Sequence: MAETAGSSGQGGGAYICFEADCSDSDTEVDSPVQCSDSSDEDLVDNANIVPGNHLELFQTQEKEAGERQISLLKRKFCLSPGTSEVEELSPGLAGIRISPPKRNPVVRRRLFDAGGRDAVRTPRDHEVNSSPEPRSQVQSGSSSRSWEGHLESINEPASDGNMAAVMHKLFKTLYIAGFGEITRVFQSDKTNNNQWVIAAHGASEVLYAASFEILSKHCSYLQASRKVHETGSMSLFLAVFNVGKSRETVRKLISGVLNTPCSRLLLQPPKIRGLCPALFWFKLGLSPATQTHGTTPDWIKQQTNVAYNTGEASKFDFGTMVQWAYDHRLTEECKIAYQYAKCAGTDLNAKAFLASTNQARLVKDCCTMVKHYLRAEEQSLTISAFIKRRCDNATGKGSWLSIMNLLKFQGIEPINFVNALKPWLKGTPKHNCIAIVGPPNSGKSLLCNTLMSFLGGKVLTFANHSSHFWLAPLTDCRVALIDDATHACWRYFDTYLRNVLDGYPVCIDRKHKSAVQLKAPPLLLTSNIDVHADEKYFYLQSRVKTFYFKEPCPASDTGEPLFFITDADWKNFFERLWERLDLSDQEDEVDEDECSQRSFTCSARNTDAMH
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.