PharMolix/UniProtQA huggingface dataset:
Protein: ZBTB1_MOUSE
Sequence: MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSRQSSKMIFGVRMYEDTVARNGNEANRWCAEPSSTVNTPHHREPEEESLQLANFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHSYQNTTRAYHRIVDIRDGKDSNIKAELAEKDSSKTFSAQPDKYREDANQAPDDSASTTGSRKSTVEAGIAGEEKSRATETKRIIIKMEPEDIPADDMKDFNIIKVTEKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRMSISVDERGGLENMRPPNNTSPIQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNADEKMDMEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKGAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSGGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT
What is the function of this protein?
Acts as a transcriptional repressor (By similarity).  Represses cAMP-responsive element (CRE)-mediated transcriptional activation (By similarity).  In addition, has a role in translesion DNA synthesis.  Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (By similarity).  Plays a key role in the transcriptional regulation of T lymphocyte development (PubMed:22201126, PubMed:22753936).
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 1.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Note=Localized in dot-like structures in the nucleus. Colocalized with SMRT in nuclear bodies. The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies (By similarity).
Protein: RGA1_YEAST
Sequence: MASTAPNEQFPSCVRCKEFITTGHAYELGCDRWHTHCFACYKCEKPLSCESDFLVLGTGALICFDCSDSCKNCGKKIDDLAIILSSSNEAYCSDCFKCCKCGENIADLRYAKTKRGLFCLSCHEKLLAKRKYYEEKKRRLKKNLPSLPTPVIDNGHTDEVSASAVLPEKTFSRPASLVNEIPSGSEPSKDIETNSSDIVPHFITGYNDSDDNSGSSKFGSNVSIDVIGPEENSTEHVNDDVKEEAEAPSANMSLNVATDPTLSCKEPPSHSRNLLNKTPLRNSSGQYLAKSPSSYRQGIIVNDSLEESDQIDPPNNSSRNASELLTSVLHSPVSVNMKNPKGSNTDIFNTGEISQMDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQEQAEKYSYSNNSGKGRKISRSLSRRSKDLMINLKSRATGKQDSNVKLSPASKVTSRRSQDLMRDNDSHTGLDTPNSNSTSLDILVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSFKSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTPKTQLENSDNFEEQKETLYENSESRNDPSLDKEIVTAEHYLKQLKINLKELESQREELMKEITEMKSMKEALRRHIESYNSEKNKLYLDSNELSNNPPMINEISLGESPPVKHVATASSVARSSVKPKFWKFFSSAKPQTEQSIQGVSTNNTNSIVKSAPVLLSAPSSGSNSGRLEISPPVLQNPNEFSDVRLVPIENDANMGQSKDGEEYLDGSNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEIEKQFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLYNLALVFAPGLIRDFSGEKDIIDMKERNYIVAFIFGNYKDILT
What is the function of this protein?
GTPase-activating protein (GAP) for CDC42 and/or RHO1.  Negative regulator of the pheromone-response pathway through the STE20 protein kinase; acts at a step between the G-protein and the MAP kinase module.  Dominant suppressor of bud emergence defect caused by deletion of IPL2/BEM2.  Involved in the control of polarized cell growth and proper bud site selection.
What are the official names of this protein?
Rho-type GTPase-activating protein 1.
Protein: SCPA_STAAM
Sequence: MYEVKLDAFNGPLDLLLHLIQKFEIDIYDIPMQALTEQYMQYVHAMKQLEINIASEYLVLASELLMIKSKMLLPQSTSDMDVDDDPREDLVGRLIEYQNYKEYTAILNDMKEERDFYFTKRPTDLSHLETDESWDPNHTIDLTELIVAYQRVKNRVELNTPKSVEIRKETFTIQQATEQVTSRLKDKDHFNFFSLFTFSEPIEQVVTHFLAILEMSKAGIINIEQQRNFEDINIIRGVNYHFG
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: PA2HB_OXYMI
Sequence: MHPAHLLVLLAVCVSLLGASDIPPLPLNLLQFGFMIECAIRNRQPALDFMNYGCYCGTVGHGTPVDDLDRCCKTRNECYAEAEKHGCYPSLTTYRWQCGRVGLHCNSKTQCEVFVCACDLAAAKCLAQEDYNPAHFNINTKARCR
What is the function of this protein?
Monomer (beta chain): Snake venom phospholipase A2 homolog that is neither toxic nor enzymatically active.  Does not bind calcium (By similarity).
What are the official names of this protein?
Neutral phospholipase A2 paradoxin-like beta chain, svPLA2, Beta paradoxin-like.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. N49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PGXB_ASPOR
Sequence: MKFFLATLFASAVSSIAVDRLIPGAQIIPESDTRALLRVGGHHDKYHDRRTITIRPSRNDTDDVSRDFLWGIKHANHGGRLLLKKGEKYVIGRKLDLTFLDDIEVQLDGELKFTDDVSYWQENNFYYDFQKSITFWRWGGKDIKIFGTGLLNGNGQRWYNEFAGQEILDPDNEYYRPILFLTENATRISVEGITQLNSPCWTNFFIQSKDVSFDDVYIHAFSTNKSALPKNSDGFDSLNVDGLTVTNTRVDVGDDCFSPKPNTTNIFVQNLLCNNTHGVSMGSIGQYPGVMDIIEHAYIENVTLLNGQNGARLKAWAGQDVGYGRINNITYKNIRIENTDAPVVLDQCYFDIEAAECAQYPSQVNVTNILFENISGTSSGKNGKVVADLVCSPNAVCSDIQLKNINLTSPAGSPPEIICEGVQGDIGVECQASAD
What is the function of this protein?
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
What are the official names of this protein?
Probable exopolygalacturonase B, Galacturan 1,4-alpha-galacturonidase B, Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBF_SACOF
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVFFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: SPEE_STRU0
Sequence: MDLWFSESHTPDVKLSVRTEEQLFVGKSEWQDISVINTPSFGKMLILNGHVLFSDADNFVYNEMVVHVPMAVHPNPEKVLIIGGGDGGVAQVLELYPDIKQIDIVEPDEMLVDVCRQYFPEFASGLDDDRVTIYHQDGLRFLRNCDSDYDIIINDATDPFGHTEGLFTKEFYGNSYRALKEDGIMIYQHGSPFFDEDESAFRSMHRKASQSFPISRVFQAHIPTVPSGYWCFGFASKKYHPIEDFKKEDWKARQLKTDYYSANLHLGAFSLPRYVEDILEEEEEK
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBA_MUSPU
Sequence: VLSPADKTNVKSTWDKIGGHAGEYGGEALERTFASFPTTKTYFPHFDLSHGSAQVKAHGKKVADALTNAVAHMDDLPGALSALSDLHAYKLRVDPVNFKLLSHCLLVTLACHHPAEFTPAVHASLDKFFSAVSTVLTSKYR
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1/2, Alpha-1/2-globin, Hemoglobin alpha-1/2 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: GCST_PROM0
Sequence: MDLRKSPLYSKYIESNAKLVDFAGWEMPISFSGLIKEHESVRSSAGLFDISHMGVISVKGINPKDYIQKFFPTNLYSFSEGQGLYTVMLNDKGGIIDDLIIYDLGIQENDITELLLIVNASRYEEDFQWIKNNLNKDEISITNFKKAKVLLALQGKKSFDLFEEWIDSSISHIPNFGCEYKIFEHISPKEKIFFSKTGYTGENGLEILLSKKAAINLWDFSISKNVAPCGLGARDTLRLEAGMHLYGQDINEETSPYEAGLGWLVHLENNHEFFGRRFLEEQSRLGIQKKLVGLFIEGKAIGRKGCTVLKGEENIGTITSGSWSPTKQQAIAFAYINTSHALINNEVQVLIRGKKFKGVITKRAFYKKNY
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: HGF_MOUSE
Sequence: MMWGTKLLPVLLLQHVLLHLLLLHVAIPYAEGQKKRRNTLHEFKKSAKTTLTKEDPLLKIKTKKVNSADECANRCIRNRGFTFTCKAFVFDKSRKRCYWYPFNSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGPMDHTESGKTCQRWDQQTPHRHKFLPERYPDKGFDDNYCRNPDGKPRPWCYTLDPDTPWEYCAIKTCAHSAVNETDVPMETTECIQGQGEGYRGTSNTIWNGIPCQRWDSQYPHKHDITPENFKCKDLRENYCRNPDGAESPWCFTTDPNIRVGYCSQIPKCDVSSGQDCYRGNGKNYMGNLSKTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNKNYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTQTTVGWMVSLKYRNKHICGGSLIKESWVLTARQCFPARNKDLKDYEAWLGIHDVHERGEEKRKQILNISQLVYGPEGSDLVLLKLARPAILDNFVSTIDLPSYGCTIPEKTTCSIYGWGYTGLINADGLLRVAHLYIMGNEKCSQHHQGKVTLNESELCAGAEKIGSGPCEGDYGGPLICEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKVILTYKL
What is the function of this protein?
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types.  Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
What are the official names of this protein?
Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Plasminogen subfamily.
Protein: Y2095_PHOLL
Sequence: MLKKTLLGLTAGALLLNASSALAANYKIDIPGQHAFIGFRIQHLGYSWLYGTFKDFDGSFTFDEQNPAENKVNVTIKIASLDTNHAERDKHLRSKDYFNTEKYPEAKFTSTEVKKEGEKYVVTGDLTLNGVTKPVILNAELMGEGKDPWGGYRAGFEASGKIKLKDFNFKADLGPKSQEADLLISIEGVREK
What are the official names of this protein?
UPF0312 protein plu2095.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: SSB_XYLFT
Sequence: MARGINKVILVGNLGNDPDIKYTQGGMTITTISLATTSVRKDKDGNTQERTEWHRVKFFGKLGEIAGEYLRKGSQCYIEGSIRYDKFTGQDGQERYVTEIVADEMQMLGGRSDGGGMGGGGERPQRQTSQRQDYAPRRQTRQPSQSPQSSPPPMDDFADDDIPF
What is the function of this protein?
Plays an important role in DNA replication, recombination and repair.  Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
What are the official names of this protein?
Single-stranded DNA-binding protein, SSB.
Protein: Y267_FRATW
Sequence: MIIVISPAKSQNFEPIKTAYQFTQPIFKQQIIKLINILKHYEVEEIEKLMKISPKLAEEVFAKHNSFNPNKYDNSNAKAAIFTFNGDVYKGLEADTLDNKTIEYAQNHLLMLSGLYGLVRPLDLIQAYRLEMGTNIKIDGKILHKYWQDKITTQLNEYFSQQQNKILINLASNEYSQAIDKKSLAVKWLDIDFKENKAGAYKTIGIHAKKARGLMTRYILENRIENVSDIKKFNVAGYQFNPDFSDENLLCFTR
What are the official names of this protein?
UPF0246 protein FTW_0267.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: HEM6_PROMP
Sequence: MSKEPPKNSREKTKNLLLKLQDNICKGLENIDGKAKFTEESWLREEGGGGKSRVLKNGSIFEQAGVNFSEVHGKELPQSIISQRPEAKGHKWFATGTSMVLHPKNPFIPTVHLNYRYFEAGPVWWFGGGADLTPYYPYLTDVRNFHKEHCNACEKVNKNLHKVFKPWCDEYFFLKHRNESRGIGGIFYDYQDGSGRIYKGNNKESKAYKESINIGELNLNWNNLFSLAENCGGAFLDSYQPIIEKRVNQNYTKEQREFQLYRRGRYVEFNLVWDRGTIFGLQTNGRTESILMSLPPLARWEYGYKAKKGSREDYLTKIFTKPQDWQNDKILEKFCKENNIFD
What is the function of this protein?
Involved in the heme and chlorophyll biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBMS1_BOVIN
Sequence: MGKVWKQQMYPQYATYYYPQYLQAKQSLVPAHPMAPPSPSTTSSNNNSSSSSNSGWDQLSKTNLYIRGLPPNTTDQDLVKLCQPYGKIVSTKAILDKTTNKCKGYGFVDFDSPAAAQKAVSALKASGVQAQMAKQQEQDPTNLYISNLPLSMDEQELENMLKPFGQVISTRILRDSSGTSRGVGFARMESTEKCEAVIGHFNGKFIKTPPGVSAPTEPLLCKFADGGQKKRQNPNKYIPNGRPWHREGEAGMTLTYDPTTAAIQNGFYPSPYSIATNRMITQTSITPYIASPVSAYQVQSPSWMQPQPYILQHPGAVLTPSMEHTMSLQPASMISPLAQQMSHLSLGSTGTYMPATSAMQGAYLPQYTHVQTAAVPVEEASGQQQVTVETSNDHSPYTFQPNK
What is the function of this protein?
Single-stranded DNA binding protein that interacts with the region upstream of the C-myc gene.  Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'.  Probably has a role in DNA replication (By similarity).
What are the official names of this protein?
RNA-binding motif, single-stranded-interacting protein 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLGA_STRU0
Sequence: MKLLFIAAEGAPFAKTGGLGDVIGALPKSLAKNGNEIAVILPYYDVIDQQFGNQVKDLFYFYTNVGWRHQYVGIKEMIRDNVTFYFIDNRDYFFRGHIYGDWDDGERFAYFQLAALEAMEKINFIPDVLHVHDYHTAMIPFLLKEKYHWIQAYQKIRTVFTIHNIEFQGQFGPGMLGDLFGVGLERYEDGTLRWNNCLNWMKAGVLYADRVTTVSPSYANEIQTVAFGKGLDQVMRMESGKLSGIVNGIDTELYNPENDPHVTFPFSINDLSGKAKNKKELQEQLGLPVNENIPLIGIVSRLTDQKGFDILVSELESILQQDLQMVVLGTGYQQYEEAFRWFANCYPEKLSANITFDIGLAQKIYASSDMFLMPSAFEPCGLSQMMAMRYGTLPIVHEIGGLKDTVEPFNPFDKTGTGFGFNHFSGFWMTNTLLFALDIFHNHKEDWQAIQKNAMSADFSWDTASLAYEKLYMDLKLF
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: REV_SIVTN
Sequence: MAGREEDANLLYTVRIIKILYDSNPYPSGAGSRTARRNRRRRWRQRQHQVDALASRILQYRLGGPQEPPHLDIPDLSKLHLDPLDQPASTETGDNQLGTQPSNSA
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs (By similarity).
What are the official names of this protein?
Protein Rev, Regulator of expression of viral proteins.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: PSMG2_HUMAN
Sequence: MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSGCARVIVLSSSHSYQRNDLQLRSTPFRYLLTPSMQKSVQNKIKSLNWEEMEKSRCIPEIDDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDALGLVEYLNEWLQILKPLSDDPTVSASRWKIPSSWRLLFGSGLPPALF
What is the function of this protein?
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.  The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
What are the official names of this protein?
Proteasome assembly chaperone 2, PAC-2, Hepatocellular carcinoma-susceptibility protein 3, Tumor necrosis factor superfamily member 5-induced protein 1.
What is the protein family that this protein belongs to?
Belongs to the PSMG2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PA_I72A3
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYIVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: GUNA_CLOLO
Sequence: MKRSLLKTCSIIAGATIIFSSLSISRNPLEVQAASMRSASEIVQEMGVGWNLGNTLDAKITNLSYNTSPISFETGWGNPVTTKAMIDKIKNAGFKTIRIPTTWGEHLDGNNKLNEEWVKRVKEVVDYCIADDLYVILNTHHEGNWVIPTYAKESSVTPKLKTLWTQISEAFKDYDDHLIFETLNEPRLEGTPYEWTGGTSESRDVVNKYNAAALESIRKTGGNNLSRAVMMPTYAASGSSTTMNDFKVPDDKNVIASVHAYSPYFFAMDTSSNSVNTWGSSYDKYSLDVELDSYLNTFKSKGVPVVIGEFGSINKNNTSSRAELAEYYVTAAQKRGIPCVWWDNNYAETNKGETFGLLNRSTLNWYFSDIKDALIRGYKNVHPEATEDDKPSTDVTNPDSGNTKPDSGNTNPGTETTTPTDNEKISITSKINDWGGAYQADFTLKNNTSSDINNWSFKIKKNDIVFTNYWDVKITEENGYYVVTPQAWKTTILANSSIVISIQGTGKVISNFEYKFD
What is the function of this protein?
Hydrolyzes barley beta-glucan, lichenan, carboxymethylcellulose and xylan.  It shows preferential activity against the larger cellooligosaccharides (cellohexaose and cellopentaose); cellotetraose is the smallest substrate degraded completely.
What are the official names of this protein?
Endoglucanase A, Cellulase A, Endo-1,4-beta-glucanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
Protein: NUDL_ECO55
Sequence: MEYRSLTLDDFLSRFQLLRPQINRETLNHRQAAVLIPIVRRPQPGLLLTQRSIHLRKHAGQVAFPGGAVDDTDASVIAAALREAEEEVAIPPSAVEVIGVLPPVDSVTGYQVTPVVGIIPPDLPYRASEDEVSAVFEMPLAQALHLGRYHPLDIYRRGDSHRVWLSWYEQYFVWGMTAGIIRELALQIGVKP
What is the function of this protein?
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
What are the official names of this protein?
Uncharacterized Nudix hydrolase NudL.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. PCD1 subfamily.
Protein: FTHS_CLOBJ
Sequence: MFKSDIEIAQESKMKNIKNIAEKIGLTEEDIDLYGKYKCKISLDVLKSNKDKKDGKLILVTAINPTPAGEGKSTVTVGLGQALWKKNKKAVIALREPSLGPVFGIKGGAAGGGYSQVVPMEDINLHFTGDMHAITSANNLLAAAIDNHIHQGNILKIDQRRILFKRVMDINDRALRNVIVALGGKINGFPREDGFMITVASEIMAILCLAEDLMNLKNKMGEILVAYSTEGKPIYCKDLEVQGAMALLMKDAIKPNLVQTLENTPAIIHGGPFANIAHGCNSILGTKMALKLGDYVITEAGFGADLGAEKFFDIKCRKANLKPNCVVIVATVRALKYNGGIPKENLKEQNMEALSKGIKNLGKHIENVNKFGVPAVVAINKFISDTEEEIEFIKKYCKELGAEVSIAEVWEKGGNGGLELADKVLDTIENKESKFNPIYEETLNIKQKIETIAQEIYGAEGVDYSKEAEKQISEIEKLDLDKKPVCMAKTQYSLSDDARLLGRPCGFRINVKEVRISNGAGFIVVLTGNVMTMPGLPKKPAANNMNVLSDGNIVGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: LOLD_LEGPH
Sequence: MNDIILTSQKLYKSYHDGTSTVEVLKGVDLAITKGDRIAIIGPSGSGKSTLLHLLGGLDKPTSGLITLGNVNWQKINEKQRCQLRNQQLGFVYQFHHLLPEFTALENVMMPLLLAGMAVKDAEEKAINMLEHVGLKPRLAHKPAQLSGGERQRVAIARALVHQPHCVLADEPTGNLDEATASKVFDLMLELNKKMNTALVIVTHDQRIAERMDRVLVLHEGSLYARE
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FCP1_SCHPO
Sequence: MSKRLTPIHLPNSLNYPIEIASCLVPQGSYVKKGTPLLLYRFFTKVKEDQEDGSEVYVDREFVEQFECPVEGELVEWAVKKEESIENFSKIVAKLHEPCTHEVNYGGLCAICGKNITSQDYMGYSDMARANISMTHNTGDLTVSLEEASRLESENVKRLRQEKRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVLRDVRSFNLQEGPSGYTSCYYIKFRPGLAQFLQKISELYELHIYTMGTKAYAKEVAKIIDPTGKLFQDRVLSRDDSGSLAQKSLRRLFPCDTSMVVVIDDRGDVWDWNPNLIKVVPYEFFVGIGDINSNFLAKSTPLPEQEQLIPLEIPKDEPDSVDEINEENEETPEYDSSNSSYAQDSSTIPEKTLLKDTFLQNREALEEQNKERVTALELQKSERPLAKQQNALLEDEGKPTPSHTLLHNRDHELERLEKVLKDIHAVYYEEENDISSRSGNHKHANVGLIIPKMKQKVLKGCRLLFSGVIPLGVDVLSSDIAKWAMSFGAEVVLDFSVPPTHLIAAKIRTEKVKKAVSMGNIKVVKLNWLTESLSQWKRLPESDYLLYPSYDLPDRNLSEHSYSSSSDDEQRISELNDRELDEIDWQAADQDVENALKDLSDDNDFDTGSISASQSQPEALEVNTPIKRKADLIQPSYNYDGEKRRKENDNHEGYDLLPNSSTKGEESAENENELDDLADIMEAELSKDTA
What is the function of this protein?
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit.  This promotes the activity of RNA polymerase II.
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase, CTD phosphatase fcp1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL24_YERPS
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNLALFNATTGKADRVGFRFEDGKKVRFFKSTSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RL24_PSEPF
Sequence: MQKIRRDDEIIVIAGKDKGKRGKVLKVLADNRLVVGGLNLVKRHTKPNPMSGVQGGIVEKEAPLHASNVAIFNGETNKADRVGFKVEDGKKIRVFKSTQKAVDA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PUR7_LISMC
Sequence: MTNELVYEGKAKRLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITSLIFSHLAGAGIESHFIRAISETEQLVKEVSIIPLEVVVRNVMAGSLAKRLGKEEGELIPNAIVEFYYKDDALDDPFINDDHVLYLELATTSEMDIIRQAARSINKVLQELFNQMNITLIDFKLEFGRDATGNILLADEISPDTCRLWDKETNQKLDKDVFRRNIGNLTDVYTEVLNRLKQVQN
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: B21_VACCW
Sequence: MEEDTNISNKVIRYNTVNNIWETLPNFWTGTINPGVVSHKDDIYVVCDIKDEKNVKTCIFRYNTNTYNGWELVTTTESRLSALHTILYNNTIMMLHCYESYMLQDTFNVYTREWNHMCHQHSNSYIMYNILPIY
What are the official names of this protein?
Uncharacterized protein B21.
What is the protein family that this protein belongs to?
Belongs to the orthopoxviruses B21 protein family.