PharMolix/UniProtQA huggingface dataset:
Protein: NFI_THEKO
Sequence: MSEGLFKKLEEVQRKLAERIVERPLEVSKIKTVGAVDVSYRDERARAAFVLCSFPDCELLKQRVVEVDVSFPYIPTFFFLRETRPVLIALGKERPDVLLVEGHGRAHPRGYGLASHIGLVLGIPTIGISKRLLRGTPEGSWVKVGKAYVSVGHLIDLPSAVEVVKTLNKNGYPLPLRIADRLSRGHTSWSGGVNDEH
What is the function of this protein?
DNA repair enzyme involved in the repair of deaminated bases.  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.
What are the official names of this protein?
Endonuclease V, Deoxyinosine 3'endonuclease, Deoxyribonuclease V, DNase V.
What is the protein family that this protein belongs to?
Belongs to the endonuclease V family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALLA_ECOL6
Sequence: MKLQVLPLSQEAFCAYGDVIETQKRDFFHINNGLVERYHDLALVEILEQDRTLISINRAQPANLPLTIHELERHPLGTQAFIPMKGEVFVVVVALGDDKPDLSTLRAFITNGEQGVNYHRNVWHHPLFAWQRVTDFLTIDRGGSDNCDVESIPEQELCFA
What is the function of this protein?
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate.  Involved in the anaerobic utilization of allantoin as sole nitrogen source.  Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.
What are the official names of this protein?
Ureidoglycolate lyase, Ureidoglycolatase.
What is the protein family that this protein belongs to?
Belongs to the ureidoglycolate lyase family.
Protein: FABA_PSEPK
Sequence: MTKQHAFTREDLLRCSRGELFGPGNAQLPAPNMLMVDRITHISEEGGKYGKGELVAELDINPDLWFFACHFEGDPVMPGCLGLDAMWQLVGFFLGWQGLPGRGRALGSGEVKFFGQVLPEAKKVTYNIHIKRVLKGKLNMAIADGSVSVDGREIYTAEGLRVGVFTSTDNF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_ECO5E
Sequence: MLQLLLAVFIGGGTGSVARWLLSMRFNPLHQAIPLGTLAANLIGAFIIGMGFAWFSRMTNIDPVWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWALLNVFVNLLGSFAMTALAFWLFSASTAH
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCR4B_ARATH
Sequence: MLSVIRVHLPSEIPIVGCELTPYVLVRRPDKNSTTDDVPESAPLEGYFLRYRWYRVQSDKKVTICSVHPTEQATLQCVFCSKRRSLVPKSYHCSPKCFTDAWQHHRTLHERAAAENNANEDDDLNRNNSAGSGSLAGSLSGSMSNLSIANNGPAPFYPSNITQKNGGETLVEVGGCKTYTPTADDISHVLKFECVVANAETKQIVGHPSTILTSRVIPAPSPSPRKLIPVNGADGMGHLDQDARIQSAGSFTVLSYNILSDTSASSDLYSYCPPWALSWPYRRQNLLREIVGYRADVVCLQEVQSDHFHEIFAPELDKHGYQALYKRKTNEVLSGSTSAIDGCATFFRRDRFSHVKKYDVEFNKAAQSLTDALIPQAQKRTALNRLVKDNIALIVVLEAKFGNQPTDPSGKRQLICVANTHVNVQQDLKDVKLWQVHTLLKGLEKIAASADIPMLVCGDFNTLPGSAPHTLLVMGKVDPMHPDLAVDPLNILRPHTKLTHQLPLVSAYSSFVRKGIMGLGLEQHRRRIDLNTNEPLFTNCTRDFIGTHDYIFYTADTLMVESLLELLDEDGLRKDTALPSPEWSSNHIALLAEFRCTPRTRRG
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.
What are the official names of this protein?
Carbon catabolite repressor protein 4 homolog 2, CCR4 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: GPA7_CAEEL
Sequence: MGHCTSKDQKEGKRLNRRIDEQIKKDQSMSLRIIKLLLLGAGESGKSTILKQMRILHKDGFSQQDLEMIRPVVYSNCIHSMLSILRAMFHLQIEYGEPDRVRDSQLVFATVHANKEELTEELAAAMQRLWHDPGVRECYRRSNEYQIDDSAKYFLDNLPRLSSPNYVPSEQDLLRTRIKTTGITEVLFELKGLTFRVIDVGGQRSERKKWIHCFDNVNAIIFISSLSEYDQTLREDNCTNRMQESLKLFDSICNSPWFADIHFILFLNKKDLFAEKIVRSPLTVCFPEYKGQQNQTECINYIQWKFEQLNRSSQREIYCHHTCATDTNNVQFVLDACLDMIIAKNLKSMGLC
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-7 subunit.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Protein: RNC_AGRFC
Sequence: MSKTKPLSADEISRLEALIGYEFKEKARLDRALTHASARSAAAGNYERLEFLGDRVLGLCVAELLFSTFRNASEGELSVRLNQLVSAESCAAIGDEMGLHNFIRTGSDVKKLTGKAMLNVRADVVESLIATLYLDGGLEASRKFILKYWQGRATSVDAGRRDAKTELQEWAHARFAATPAYRVDDRSGPDHDPSFTVTVEIPGVKPETGVERSKRAAEQVAATRLLEREGVWRKSPTGN
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTNB_XANOP
Sequence: MNATTAPLPYSAARLHELAHVLIANIRELAHAGWTPATSSNFSHRLDEQHAAITVSGRDKGRLVEEDIMVVDFDGLAVGRPLRPSAETLLHTQLYRRFPEICCVLHTHSPVQTIASRLYAGSDVIRLEGYELLKAFEGNTTHETAVEVPVFANTQDMQVLAAQVDALLDKQSMWGYLIEGHGLYAWGRNMAEARRHLEAFEFLLQCELELLKLRGTRQVVPVPHS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: MURG_YERPN
Sequence: MSGKTKRLMVMAGGTGGHVFPGLAVAHHLMAQGWQVRWLGTADRMEASLVPQHGIEIDFIKISGLRGKGLMAQLTAPIRIYRAVRQAQKIMRDYQPNVVLGMGGYVSGPGGLAAWLCGVPVVLHEQNGIAGLTNRWLARIAKKVLQAFPGAFPNADVVGNPVRTDVLALPLPAVRLSGREGPIRVLVIGGSQGARILNQTLPLVAASLGEQITLWHQVGKGALPEVSQAYQQAGQAGHLVVEFIDDMAAAYAWADVVVCRSGALTVSEVAAAGLPAIFVPFQHKDRQQYWNALPLEKAGAAKIIEQPQFTATSVSSLLASWDRATLLSMAERARSVAIPDATERVAAEVVAASKSA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SP1L3_ARATH
Sequence: MGKARGVNNGVNESSLGYLFGSGQPSSAAAATMGTTTTTTTTTTTDGTGGRPITTTTTTVTDNKKTSAGVRGSPNNYFRSEGQNCGNFLTDRPSTKVHAAPGGGSSLDYLFGGPSPAGSGNK
What is the function of this protein?
Acts redundantly with SPR1 in maintaining the cortical microtubules organization essential for anisotropic cell growth.
What are the official names of this protein?
Protein SPIRAL1-like 3.
What is the protein family that this protein belongs to?
Belongs to the SPIRAL1 family.
Protein: SNTB2_MOUSE
Sequence: MAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAVEPEPPAAAFNGLPNGGGGESLPGSPNRGLGPPSPPAPPRGPAGEASASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGASPQSPSFSGSEDSGSPKHQNTTKDRKVIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVETHRDLSTWTRILVQGCHAAAELIKEVSLGCTLSGQEVRFTVHYEHGFTITRDNGGASSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV
What is the function of this protein?
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins.  May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.  May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity).
What are the official names of this protein?
Beta-2-syntrophin, 59 kDa dystrophin-associated protein A1 basic component 2, Syntrophin-3, SNT3, Syntrophin-like, SNTL.
What is the protein family that this protein belongs to?
Belongs to the syntrophin family.
What are the subcellular locations of this protein?
Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction. Cytoplasm, cytoskeleton. Note=Membrane-associated. In insulinoma cell line, it is enriched in secretory granules (By similarity). In muscle, it is exclusively localized at the neuromuscular junction.
Protein: BARF1_EBVA8
Sequence: MARFIAQLLLLASCVAAGQAVTAFLGERVTLTSYWRRVSLGPEIEVSWFKLGPGEEQVLIGRMHHDVIFIEWPFRGFFDIHRSANTFFLVVTAANISHDGNYLCRMKLGETEVTKQEHLSVVKPLTLSVHSERSQFPDFSVLTVTCTVNAFPHPHVQWLMPEGVEPAPTAANGGVMKEKDGSLSVAVDLSLPKPWHLPVTCVGKNDKEEAHGVYVSGYLSQ
What is the function of this protein?
Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1.  May inhibit interferon secretion from mononuclear cells.  Exhibits oncogenic activity in vitro (By similarity).
What are the official names of this protein?
Secreted protein BARF1, 33 kDa early protein, p33.
What are the subcellular locations of this protein?
Secreted. Note=Massively secreted in the serum of EBV-induced nasophyryngeal carcinoma patients.
Protein: CDKL2_RABIT
Sequence: MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDDQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMLMGEPLFPGDSDIDQLYLIMRCLGNLIPRHQELFYKNPVFAGVRLPEIKESEPLERRYPKLSEVVIDLAKKCLHVDPDKRPFCAELLHHDFFQMDGFAERFSQELQMKVQKDARNISLSKKSQNRKKEKEKDDSLGEERKTLVVQDTNVDSKFKDSKVFKIKGSKIDGEKVDKGNRAAVSMTVGPSHIKAVPSTSLRDCSNVSVDHTRNPGMAIPPLTHNLSAVAPGINSGMGTIPGVQSYRVDEKTKKYCIPFVKPNKHSPSGIYNMNVTTSVSSEKNLLQANKKRGEYSKTDVRLPELNYNHLPELRALEGIARNSRLIRKENKILSESRIPSLAAIDLHTPNIAVHQVSGSPLSDGSEADSPWMEHQH
What are the official names of this protein?
Cyclin-dependent kinase-like 2, Serine/threonine-protein kinase KKIAMRE.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TBA3_CHICK
Sequence: ADQCSGLQGFLVFHSFGGGTGSGFTSLLMERLSVEYSKKSKLEFSVYPDRQVSTAVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICNRNLDIERPTYTNLNRLIGQIVSSVTASLRFNGALNVDLIEFQTNLVPYPRIHFPLTTYARIISAEKAYHEQLSVPEITNACFEFSNQMVKCDPRRGKYMACCLLYRGDVVPKDVNAAIAAIKTRRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGRNSADGGEFEE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-3 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: AP1_KLULA
Sequence: MSTSTAKRPFDNKRAGSPDDGTDSDSGGNNSGSSPASKRRERKPGRKPLETEAKDKRTAQNRAAQRAFRERRERKMKELEDKVSQLESLNKQSELETKFLRNQVTNLLSELKRYNPELPKKRDSILLDYLAKQRKASIDSNPDFSAAANKAANSKDSSTAISSSNFQFEFPWKMDPSKIPSPSSDSTSPSASTSILDNANNKSVSSTNLNHSRSSISNSSSSPSNVNGLSSRKHSNTLNLYQTQSNVTSEFDFDSQFDESVSSFCSKLSMACGTKSNPIPKASPVSTPSSSDLLKPKSNSNVNITNHNNNKINSKDLSSSAPLHDSASASALNNHDSVNAVSNQFSVDKQYNDSSHSQATPNGLDNDSSVSAWQQPSFGQLGFRTDQLFDLDLDSASPITKQKDNNYSTTTNNTNSPAKADGMYWNFNTPLSNMVSRNMQNPEIPFIDTGLAFPDYDDPLLDILKEEQENEQVEGDSDPIQALINEEPSMPLCHDPAANAGASVSETDKLSNQEEIVQDIIPSNDGKLLKCSEVWDRITAHPRYSDLDIDGLCLELRTKAKCSEKGVVVNAEDVQKALISHMQ
What is the function of this protein?
Transcription activator involved in oxidative stress response and cadmium resistance (PubMed:9439570).  Regulates the transcription of genes encoding antioxidant enzymes and components of the cellular thiol-reducing pathways.  Activity of the transcription factor is controlled through oxidation of specific cysteine residues resulting in the alteration of its subcellular location.  Activation by alkyl hydroperoxides or cadmium induces nuclear accumulation and as a result YAP1 transcriptional activity (By similarity).
What are the official names of this protein?
AP-1-like transcription factor YAP1.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. YAP subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Oxidized YAP1 is found predominantly in the nucleus, while reduced YAP1 is continuously exported to the cytoplasm by CRM1/exportin 1.
Protein: ALF1_STAAC
Sequence: MNKEQLEKMKNGKGFIAALDQSGGSTPKALKEYGVNEDQYSNEDEMFQLVHDMRTRVVTSPSFSPDKILGAILFEQTMDREVESKYTADYLADKGVVPFLKVDKGLAEEQNGVQLMKPIDNLDNLLDRANERHIFGTKMRSNILELNEQGIKDVVEQQFEVAKQIIAKGLVPIIEPEVNINAKDKAEIEKVLKAELKKGLDSLNADQLVMLKLTIPTEPNLYKELAEHPNVVRVVVLSGGYSREKANELLKDNAELIASFSRALASDLRADQSKEEFDKALGDAVESIYDASVNKN
What are the official names of this protein?
Fructose-bisphosphate aldolase class 1, Fructose-bisphosphate aldolase class I, FBP aldolase.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
Protein: RAN_DANRE
Sequence: MAENEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGAIKYNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVEMPALAPPEIAMDPTLAAQYEHDLKVASETALPDEDDDL
What is the function of this protein?
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs.  Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis.  Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way.  Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport.  Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins.  RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation.  Required for normal progress through mitosis.
What are the official names of this protein?
GTP-binding nuclear protein Ran, GTPase Ran, Ras-related nuclear protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ran family.
What are the subcellular locations of this protein?
Nucleus. Nucleus envelope. Cytoplasm, cytosol. Cytoplasm. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis (By similarity).
Protein: PMP3_CRYNJ
Sequence: MAFTCSDIFKIILAIILPPLGVFLERGCGADLLINILLTILGYIPGIIHALYIILKY
What is the function of this protein?
Plays a role in the regulation of membrane potential.  Could mediate a proton leak (By similarity).
What are the official names of this protein?
Plasma membrane proteolipid 3.
What is the protein family that this protein belongs to?
Belongs to the UPF0057 (PMP3) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AGL12_ARATH
Sequence: MARGKIQLKRIENPVHRQVTFCKRRTGLLKKAKELSVLCDAEIGVVIFSPQGKLFELATKGTMEGMIDKYMKCTGGGRGSSSATFTAQEQLQPPNLDPKDEINVLKQEIEMLQKGISYMFGGGDGAMNLEELLLLEKHLEYWISQIRSAKMDVMLQEIQSLRNKEGVLKNTNKYLLEKIEENNNSILDANFAVMETNYSYPLTMPSEIFQF
What is the function of this protein?
Probable transcription activator that regulates root development by controlling cell proliferation in root meristem.  May mediate responses to auxin in the root.  May act as promoter of the flowering transition through up-regulation of SOC, FT and LFY.
What are the official names of this protein?
Agamous-like MADS-box protein AGL12, Protein XAANTAL 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS18_BORPA
Sequence: MAFFGKRKEKRKFTQQNPLFKRRKFCRFTAAGVEEIDYKDLDTLRDFVQENGKIIPARLTGTRAIYQRQLDTAIKRARFLALLPYTDNHK
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MFN2A_XENLA
Sequence: MELEAVLKERTAAAGDPGRVLGAWVRSGWSAAGPSVLESEGGSGGPLAFESTSSRILELASKDNEPEYEALPDGSNVTTHMLAGAVAGVMEHCLMYPVDCVKTRMQSLQPDPAARYRNVMDALSKIVRTEGFWRPLRGLNVTATGAGPAHALYFACYEKLKKTLSDIIHPGGNSHIANGTDYSCPA
What is the function of this protein?
Mitochondrial iron transporter that mediates iron uptake.  Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells.
What are the official names of this protein?
Mitoferrin-2A, Mitochondrial iron transporter 2-A, Solute carrier family 25 member 28-A.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VKT3_STIHA
Sequence: MAKLYFLLCLALVACLTMATEEMPALCHLQPDVPKCRGYFPRYYYNPEVGKCEQFIYGGCGGNKNNFVSFEACRATCIIPL
What is the function of this protein?
Dual-function toxin that inhibits both the serine protease trypsin and voltage-gated potassium channels (Kv).
What are the official names of this protein?
KappaPI-stichotoxin-Shd2a, KappaPI-SHTX-Shd2a, Kunitz-type protease inhibitor and potassium channel toxin SHTX III, Kunitz-type protease inhibitor and potassium channel toxin SHTX-3.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. Sea anemone type 2 potassium channel toxin subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: ORF3_HEVME
Sequence: MGSPPCALGLFCCCSSCFCLCCPRHRPVSRLAAVVGGAAAVPAVVSGVTGLILSPSQSPIFIQPTPLPQTLPLRPGLDLAFANQPGHLAPLGEIRPSAPPLPPVADLPQPGLRR
What is the function of this protein?
Small multifunctional phosphoprotein involved in virion morphogenesis, egress and counteracting host innate immunity.  Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway.  Acts also as a viroporin and forms ion conductive pores allowing viral particle release.  Impairs the generation of type I interferon by down-regulating host TLR3 and TLR7 as well as their downstream signaling pathways.  Down-regulates the phosphorylation of host IRF3 via the interaction with host SIRP-alpha, thereby inhibiting IFN-I expression.  Interacts with host microtubules.
What are the official names of this protein?
Protein ORF3, pORF3.
What is the protein family that this protein belongs to?
Belongs to the hepevirus ORF3 protein family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane. Host cytoplasm. Note=The N-terminal region seems to associate with the cytoskeleton probably via one of its hydrophobic regions.
Protein: PUR5_HISS2
Sequence: MSKQSLSYKDAGVDINAGNTLVERIKSDVKRTTRPEVIGGLGGFGALCALPSKYKDPILVSGTDGVGTKLRLAIDLKKHDTIGVDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDVAADVIKGIADGCVQAGCALVGGETAEMPGMYHTGDYDLAGFCVGVVEKSEIIDGSNVKAGDALLALASSGPHSNGYSLIRKVIEVSGIDPTTAQLAEHSFAEQVLAPTKIYVKPVLQLIKHTDVHAICHLTGGGFWENIPRVLPSSVKAVINEKSWEWHPIFKWLQEQGNIDRYEMYRTFNCGVGMIIALPQEDVETALALLQQVGEKAWVIGKIEHANADEEKVVIC
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_CAMJ8
Sequence: MIIELAKNYGFCFGVKRAIKKAEQIKDAATIGPLIHNNEEISRLQKNFNVKTLENIQALSNEKKAIIRTHGITKQDLEELRKKDIEIFDATCPFVTKPQQICEQMSKEGYEVVIFGDENHPEVKGVKSYVSTKAYVVLDKKELQNIKLPNKIAVVSQTTKKPEHFMEIVNFLILKTKEVRVFNTICDATFKNQDAIKELSLKSDVMVVVGGKNSANTKQLFLIAKTNCEDSYLIETEEELKKEWFLDKKHCGISAGASTPDWIIQKVIAKIENFKIN
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: NRDR_ENT38
Sequence: MHCPFCSAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRKGMLKALEKRPVSADDVEMALNHIKSYLRGTGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLQD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PLD3B_MOUSE
Sequence: MKIWTSEHVFDHPWETVTTAAMQKYPNPMNPSVVGVDVLDRHVDPSGKLHSHRLLSTEWGLPSIVKSLIGAARTKTYVQEHSVVDPVTRTMELKSTNISFTNMVSVDERLTYKPHLQDPEKTVLTQEALITVKGVSLSSYLEGLMASTISSNASKGREAMEWVIHKLNAEIEELAASARGSIRTPMAAAAALVDK
What are the official names of this protein?
PRELI domain containing protein 3B, Protein slowmo homolog 2.
What is the protein family that this protein belongs to?
Belongs to the slowmo family.
Protein: RUVC_PROM9
Sequence: MRIIGIDPGLARVGYGIIEIKNDKKILLDCGVIETGKEKKEEDRLYEIFKDLNELISHWKPNLAAVEKFFFYRSSTTISVVQARGVIMMVLASKKINISEYSPAQIKLTIAGSGKASKKEVLDAVMYNLELNKPPKPDDSADALAIALTKLNEEGFN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.