PharMolix/UniProtQA huggingface dataset:
Protein: SECA_KLEP7
Sequence: MLIKMLTKVFGSRNDRTLRRMRKVVNIINGMEPAMEKLSDDELKAKTAEFRARLEKGETLESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMTVGINMSGLPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYRKVNKIIPHLIRQEKEDSDTFTGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMDEGESLYSPTNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDMADLVYMTEAEKIQAIIEDIKTRTAAGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHASEADIVAQAGYPSAVTIATNMAGRGTDIMLGGSWQAEVAALENPTPEQIEKIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSETINSIREDVFKATIDAHIPPQSLEEMWDIEGLQERLKNDFDLDLPIKEWLDKEPELHEETLRERILQSAVETYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEAMEQQRREEAERLAQMQQLSHQSDDEAAAQDLAAQTGERKVGRNDPCPCGSGKKYKQCHGRLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ACCA_BURO0
Sequence: MKTTFLDFEQPIAELEAKIEELRFVQDDSAVDISEEIERLSKKSQQLTKDLYANLSPWQVSQIARHPQRPYTLDYVAELFTDFHELHGDRAFADDLSIVGGLARFGGHPCMVIGHQKGRDTKERAARNFGMPRPEGYRKAERLMRLAEKFGLPIFTFVDTPGAYPGIGAEERGQSEAIGRNLYVMAELKTPIITTVIGEGGSGGALAIAVADTVMMLQFSTYSVISPEGCASILWKSAAKAPEAAEALGLTAHRLKALGLIDKIINEPLGGAHRDPKGMAALLRRALADSLRQFQGMSIDALRERRFERLMAYGKFKETTPGA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
Protein: SUB2_ASPFU
Sequence: MSHEEDLIDYSDEELQTTDAAATTAAPAANGAQDKKGDLTVSGGRPDKKGSYVGIHSTGFRDFLLKGELLRAITDCGFEHPSEVQQVCIPTAILNVDVLCQAKSGLGKTAVFVLTTLHQLEPVPGECSVLVMCHTRELAYQIKNEYARFSKYLPDVKTAVFYGGTPIQKDIEVLSNKESYPNIVVGTPGRLNALVREKKLSLRNVKAFVLDECDKMLDQIGKQAQIAHMRRDVQEIFRATPADKQVMMFSATLSQEIRPICKKFMRNPLEVYVDDDTKLTLHGLQQYYIKLSESEKNRKLNELLDSLEFNQVIIFVKSTLRANELDKLLRECNFPSIAVHSGVSQEERIKRYKEFKEFNKRICVATDVFGRGIDIERINLAINYDLPADADSYLHRVGRAGRFGTKGLSISFVSSEEDEKVLKEIEKRFEVALPEYPEGGVDSSTYMA
What is the function of this protein?
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus.  SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly.  May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase sub2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ENO1_CHLTE
Sequence: MKIQNVNAIEILDSRGNPTVEVNLKLEDGTISRAMVPSGASTGEREATELRDGDKKRYGGKGVLKAVENVNSAIAKAIENKHFTNQRELDYFLIELDETNNKSKLGANAILGVSMAFARAKAQSSRTPLYQYLGGSNAHIMPVPCMNVINGGKHADNTIDFQEFMIAPHNAPSFRESIRMGEEVFHALKAVLKLKGLSTGVGDEGGFAPDLKSNEQAVEMILEGITKAGYKPSVDVSICLDPASSEMWENGKYKFFKSTQKLVSSDEMVKLWESWVNQYPIVLLEDGMAENDWEGWKNLTDVIGNKIEIVGDDLFCTNKSILLNGINKGVANSILIKLNQIGTVTETLETIELAYKNSYNCFVSHRSGETVDSFIADLTVGINAGHLKSGSGCRGERIEKFNQLMRIENELGKSAQFAGLKAFKNAK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase 1, 2-phospho-D-glycerate hydro-lyase 1, 2-phosphoglycerate dehydratase 1.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RF3_COXB1
Sequence: MSVEKQTAMRRTFAIISHPDAGKTTLTEKLLLFGGAIQLAGTVKSRKAARHATSDWMELEKQRGISVTTSVMQFPYKDYLINLLDTPGHADFTEDTYRTLTAVDSALMVIDAAKGVEPRTIKLMEVCRLRHTPIMTFINKMDRDTRPSIELLDEIESILRIHCAPVTWPIGMGKYFKGIYHLIEDAIYLYQPGKHERVGESERIEGINNPELDKKLGDLASELRNEIELVKGASHPFEREGYLKGELTPIFFGSAINNFGVGELLDAFVKEAPPPQGRETNSRLVKPEEEKFSGFVFKIQANMDPGHRDRIAFLRIASGQYQKGMKAYHVRLKKEIQINNALTFMAGKRENAEEAWPGDIIGLHNHGTIQIGDTFTQGERFKFTGIPNFASELFRLVRLKDPLKQKALLKGLTQLSEEGATQLFRPLDSNELILGAVGLLQFDVVAYRLENEYNVKCVYESVNVVTARWVICDDKAVLERFNQEQSRNLAYDGGGHLTYLAPSRVNLEITMEKWPEIQFSETREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTIP_METJA
Sequence: MIGIIGGTGIAEILKGDKEEIINTKYGKARVIIDKENEVVLLFRHGVRHNIPPHKINYRANIYALKKLGVERILAINSVGSLKEDLKPGMFFVPNDFIEFTKKREETFYDEGKVVHIDMTDPYCPELRNILKSILDKNNFSYGEGVYVCTEGPRFETKKEIAIYKNWGDVVGMTGYPEVVLARELEMCYVSLCNITNYACGISKNILTVDEVLEKIKEMENKILKVVEDFINYGFGERKCICKDALKHAVIG
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis.  Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
What are the official names of this protein?
Probable S-methyl-5'-thioinosine phosphorylase, 5'-methylthioinosine phosphorylase, MTI phosphorylase, MTIP.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein: TIG_PAEAT
Sequence: MKSAVENLTATRVKLNVEVPFEELKPSIDAAYKTVASQIQVPGFRKGKVPSKLIDQRVGRGYVLETAINDGLNGWYQAAVQETGVRPLSRPEVEITEVPDPSATDGELKFQVEIDVRPEIELPDYAGIKVEVAAAESSEADVDKSLDELRGRFGTLKSVERPAKNDDFLTIDITATIDGEDIDSAAGLSYQVGAGTMLEGLDEAVTGLSADEEAIFETTLVGGDHAGESAQVKVVVKAVKERELPEANDDFAQLASEFDTLAELREDLAKQAADSKVVEQGVEARDKVLDKLVELVEVPVPDSVVEEQIEAHFNPENAHGEGDHDTEEHRAEVKANTERAFQNEIILDAIADKEEVDVSQNELIDYIVTTASQYGMDPNQFAQIIDQSGQVPMMVSEVRRRKALAVVLGQAEVVDSEGNKVDLTDFVRPAGEAAAEEAAAGEANEEADVVASDDPAAVKF
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: CYSC_ECO7I
Sequence: MALHDENVVWHSHPVTPQQREQHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: MOAB_HALH5
Sequence: MSVEQHRKEAPKTVRCMILTISDTRTYDTDKSGALIRELLEAKGHQVTEYQIVKDEYSQIQHWLKVAAGRADIDAILLNGGTGIALRDTTYEAVRDSLDKEMPGFGEIFRLLSFQEDIGTAAILSRAIAGVRDGKAIFSMPGSTGAVKLAMTRIIIPELGHVMREILKDR
What is the function of this protein?
May be involved in the biosynthesis of molybdopterin.
What are the official names of this protein?
Molybdenum cofactor biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the MoaB/Mog family.
Protein: ATPA_LEUMM
Sequence: MAIQAEEISALIKQQLEKFDTTLTVEEVGTVTYVGDGVARATGLANALAGELVEFANGTYGMAQNLESSEVGIIILGGFDDIREGDTVKRTGRIMEVPVGEQLIGRVVNALGQPIDGLGEIKTDKTRPVEVKAPGVMERKSVSEPLQTGIKAIDALVPIGRGQRELIIGDRKTGKTSLAIDTILNQKDQNMIVIYVAIGQKNSTVRAQVETLRQMGAMDYTIVVNAGPSEPAPMLYLAPYVGAAMGEEFMYNGKHVLIVYDDLSKQATAYRELSLILRRPPGREAYPGDVFYLHSRLLERAAKLSDELGGGSMTALPFIETQAGDVSAYIPTNVISITDGQVFLDADQFYAGVRPAIDAGTSVSRVGGDAQIKAMKKVAGTLRLDLASFRELESFAQFGSDLDSATQAKLARGRRTVEILKQPLNKPMPVQHQVVVLYALTHGYLDDVEVADIQRFQDELIAYVDANASELFKAIVETKNLPEEADLNAAIEAFKAGFAGSESAE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y2315_STAA3
Sequence: MKRLVTGLLALSLFLAACGQDSDQQKDGNKEKDDKAKTEQQDKKTNDSSKDKKDNKDDSKDVNKDNKDNSANDNQQQSNSNATNNDQNQTNNNQSSNNQANNNQKSSYVAPYYGQNAAPVARQIYPFNGNKNQALQQLPNFQTALNAANNEANKFGSNNKVYNDYSIEEHNGNYKYVFSFKDPNANGKYSIVTVDYTGQAMVTDPNYQQ
What are the official names of this protein?
Uncharacterized lipoprotein SAUSA300_2315.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: HRCA_CHLSY
Sequence: MSGPLTERRQMILKLVIQEFVDTATPVASETLVRKYRLPVSSATVRNDMAALEELGFLTHPHTSGGRIPTDAGYRFFVENLMERTTLSPAEQRMIRHQFYQVRGELDQWVQLACAVLARTAHNASVATAPRAEQLRFKSLELIAIHETMALAVIVFHGGIVKQQTLPIEPGRTPEDLRRAAGLVSDLLADATLSRAEELAAIATFNGVPLSEFERTLVDLVVRAMSVFEEQAQEQIYSDGILEMLSQPEFLPASGRDDAERAIERLRRTLEILKSGRGLSPLIPQALASGGVQVIIGGEHSEDTMRDYSVILARYGVEGALVGVLGVIGPTRMAYPRSISTVRYIASLMTNLLADLYHVNTRPSDIEPAAEL
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: FAA32_MYCS2
Sequence: MPFHNPFIKDGQIKFPDGSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIAVDAVPDDVASTWVNPDEPDETTIAYLQYTSGSTRIPTGVQITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATDDATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKAIRTGYVAAFSVPANQLPDEVFENAHSGIKRDPDDTSEQLVIVAERAPGAHKLDIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLRAGKVANDFPDATD
What is the function of this protein?
Involved in the biosynthesis of mycolic acids (By similarity).  Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the phosphopantetheine arm of the polyketide synthase Pks13 for further chain extension (By similarity).  Can use decanoate (C10), dodecanoate (C12) and tetradecanoate (C14) (PubMed:23364516, PubMed:26900152).
What are the official names of this protein?
Long-chain-fatty-acid--AMP ligase FadD32, FAAL, Acyl-AMP synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: 5MP2_XENTR
Sequence: MNNQKQQKPTLSGQRFKTRKRDEKERFDPTQFQDCIIQGLNETGNDLEAVAKFLDASGAKLDYRRYAETLFDILVAGGMLAPGGTLADEVIRTDVCVFSAQEDLETMQAFAQVFNKLIRRYKYLEKGFEEEVKKLLLFLKGFSESERNKLAMLTGILLANGNLSASILNSLYNENLVKEGVSAAFAVKLFKSWINEKDINAVAGSLRKVNMDNRLMELFPANKQTVEHFTKYFTDAGLKELAEYVRNQQTIGARKELQKELQEMMSRGEPLKEISMYVKDEMKKNNISEQTVIGILWSSVMSCVEWNKKEELVTEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKSFQKIVVLFYKAEVLSEEPILKWYKDAHLAKGKSVFLEQMKKFVEWLKNAEEESESETEEGD
What is the function of this protein?
Translation initiation regulator which may repress repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (By similarity).  Enhances histone H4 gene transcription but does not seem to bind DNA directly (By similarity).
What are the official names of this protein?
eIF5-mimic protein 2, Basic leucine zipper and W2 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the BZW family.
Protein: ATP6_STAAW
Sequence: MDHKSPLVSWNLFGFDIVFNLSSILMILVTAFLVFLLAIICTRNLKKRPTGKQNFVEWIFDFVRGIIEGNMAWKKGGQFHFLAVTLILYIFIANMLGLPFSIVTKDHTLWWKSPTADATVTLTLSTTIILLTHFYGIKMRGTKQYLKGYVQPFWPLAIINVFEEFTSTLTLGLRLYGNIFAGEILLTLLAGLFFNEPAWGWIISIPGLIVWQAFSIFVGTIQAYIFIMLSMVYMSHKVADEH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PHS_XYLFM
Sequence: MNDRITLAQAHCQPREKKEHKLGQARLAELLPQVPGWELSNNGHALTRTFQFDNYYRTLAFVNALAFIAHCEDHHPDMNVHYGRAVVCFSTHKIGGISEIDFICAAKTSALYEQGI
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: OHRL_STAHJ
Sequence: MAVQYETKATNVGGRKGHVNTDDNAINVDVLPPQQADGNATNPEQLFAAGYASCFNGAFDLILKQNKVRDAEPEVTLTVRLEDDPDAESPKLSVAIDAKVKNVLSQEDAEKYLQDAHEFCPYSKATRGNIDVDLNLQVVD
What are the official names of this protein?
Organic hydroperoxide resistance protein-like.
What is the protein family that this protein belongs to?
Belongs to the OsmC/Ohr family.
Protein: QUEC_BURL3
Sequence: MIRTDAKDGALVLFSGGQDSATCVAWALERYQTVETLGFDYGQRHRVELECREGVREALKRDFPAWSDRLGDDHMIDLSVLGAISDTAMTRTIEIETAANGLPNTFVPGRNLMFMTIAAAIAYRRGLRVLVGGMCETDFSGYPDCRDDTMKALQVALNLGMDTRVVLETPLMWLDKAQTWQLAEQLGGEALVELIRVETHTCYVGERAELHDWGFGCGECPACKLRKRGYEAYLKGERVTEAPL
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RS3_LEPBP
Sequence: MGQKVNPIGLRIGITRNWDSVWFSKQDYIKNLHEDIKIRRFLQKKFKNASVVKIIIERFPEKINVNLHTSKPGMVIGQKGQNIEAVKQELKKFADKPIGMNIIEVKKPEIIAQAIAETVALQIEQRMPFRRVMKAELRRAMRGGVEGVKIQISGRLNGADMARTEKYMEGRVPLHTLRAKIDFGFKEALTTFGQIGVKVWTYTGDYFPTKEESDEDKYAVKRRTS
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PPAC_STRPN
Sequence: MSKILVFGHQNPDSDAIGSSVAFAYLAKEAYGLDTEAVALGTPNEETAFVLNYFGVEAPRVITSAKAEGAEQVILTDHNEFQQSVSDIAEVEVYGVVDHHRVANFETASPLYMRLEPVGSASSIVYRMFKEHGVAVPKEIAGLMLSGLISDTLLLKSPTTHPTDKIIAPELAELAGVNLEEYGLAMLKAGTNLASKSAEELIDIDAKTFELNGNNVRVAQVNTVDIAEVLERQAEIEAAMQAANESNGYSDFVLMITDIVNSNSEILALGANMDKVEAAFNFKLENNHAFLAGAVSRKKQVVPQLTESFNA
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_MYCTU
Sequence: MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKPQVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLLPAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: ABR_BOVIN
Sequence: MEPLSHRGLPRLSWIDTLYSNFSYGADDYDAEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDSISPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSRDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSEGSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQSGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPVNKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQVLLYYLQHPPISFAELKRNTLYFSTDV
What is the function of this protein?
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins.  The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42.  Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form.  The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1.  Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity).  Functions as an important negative regulator of neuronal RAC1 activity (By similarity).  Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (By similarity).
What are the official names of this protein?
Active breakpoint cluster region-related protein.
What are the subcellular locations of this protein?
Cell projection, dendritic spine. Cell projection, axon. Synapse.
Protein: LEUC_THISH
Sequence: MTGKTLYDKLWDAHVVRTEPDGTALLYIDRHLVHEVTSPQAFEGLRLAGRKPWRTDTVLAVPDHNVPTTHRDQGISDPVSRIQVETLDANVHEFGITFFPMNDVRQGIVHVIGPEQGATLPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLLQKKMKNMLVSVDGRVGPGVTAKDIVLAIIGEIGTAGGTGYAIEFGGEAIRDLSMEGRMTVCNMAIEAGARAGMVAVDETTIEYVKGRTYAPTGEQWESAVAAWRELNSDADARFDRVVRLDATAIAPQVSWGTSPEMVVPVTGRVPDPAEATDPVKASGMKRALEYMGLAANTPIEQIAIDKVFIGSCTNSRIEDLRAAAAVVRGRKVAGNVKLAMVVPGSGLVKQQAEQEGLDQVFLEAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAVTGHFTDVRQLAQS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: NDUS2_CAEEL
Sequence: MLGRKIAGTCLRANVPSVAATSSTPATQTRNSHTIWYPDAKFERQFKTGGTLGKLWMSERVSDFDEKIGLDKLEKLAYSDPVMSDNYSGKQREKNLENMILNFGPQHPAAHGVLRLVLKLEGEVIIKAIPHIGLLHRATEKLIEHKTYTQALPYFDRLDYVSMMCNEQAWSLAVEKLLGIDIPTRAKYIRTLMGELTRIQNHIMGITTHALDVGAMTPFFWMFEEREKLFEFSERVSGARMHANYVRPGGVAWDLPIGLMDDIYDWAIKFPERIDELEDMLTENRIWKARTIDIGLVSAADALNWGFSGVMVRGSGIKQDVRKTEPYDAYADMEFDVPIGTKGDCYDRYLCRIEEMRQSLNIVHQCLNKMPAGEIKVDDHKVVPPKRAEMKENMESLIHHFKFFTEGFQVPPGATYVPIEAPKGEFGVYLVADGTGKPYRCFIRAPGFAHLAAIHDVCYMSLIADIVAVIGTMDIVFGEVDR
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial, Complex I-49kD, CI-49kD, NADH-ubiquinone oxidoreductase 49 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: XYN6_MAGGR
Sequence: MRTPAIVLALAPAAAFGQAALWGQCGGQGWTGAKTCVSGAVCQAQNEWYSQCVPGSGGGNPPTPQPTQPSNPPPSTGSGLNAKFKNKGKLYFGTSMDHYDLNKAQLTNIVKAQFGQITNENSMKWDAIEPSRNSFSWTNADAVVNFATANGKLMRGHTLLWHSQLPAWVSNINDRNTLTQVIQNHVTAMVTRYRGKILQWDVVNEIFAEDGSLRSSVFSRVLGEDFVGIAFRAARAADPNAKLYINDYNLDIANYAKVTRGMVEKVNKWVSQGIPIDGIGSQAHLAQPGGWNPASGVPAALRALAAANVKEIAITELDIAGASANDYVTVVNACLQISKCVGITVWGVSDAISWRPNDNPLLYDRNYQPKAAYTAIMNAL
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
What are the official names of this protein?
Endo-1,4-beta-xylanase 6, Xylanase 6, 1,4-beta-D-xylan xylanohydrolase 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 10 (cellulase F) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MSCL_ECO8A
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PPO_ZINOF
Sequence: EQGVGGDDGL
What is the function of this protein?
Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.
What are the official names of this protein?
Polyphenol oxidase, PPO, Catechol oxidase.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.