PharMolix/UniProtQA huggingface dataset:
Protein: PHOL_SHIFL
Sequence: MNIDTREITLEPADNARLLSLCGPFDDNIKQLERRLGIEINRRDNHFKLTGRPICVTAAADILRSLYVDTAPMRGQIQDIEPEQIHLAIKEARVLEQSAESVPEYGKAVNIKTKRGVIKPRTPNQAQYIANILDHDITFGVGPAGTGKTYLAVAAAVDALERQEIRRILLTRPAVEAGEKLGFLPGDLSQKVDPYLRPLYDALFEMLGFEKVEKLIERNVIEVAPLAYMRGRTLNDAFIILDESQNTTIEQMKMFLTRIGFNSKAVITGDVTQIDLPRNTKSGLRHAIEVLADVEEISFNFFHSEDVVRHPVVARIVNAYEAWEEAEQKRKAALAAERKREEQEQK
What are the official names of this protein?
PhoH-like protein.
What is the protein family that this protein belongs to?
Belongs to the PhoH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_STAEQ
Sequence: MKTLNHLNKMKASQQKISMVTAYDYPSAKQAQQAEIDMILVGDSLGMTVLGYDSTVQVTLNDMIHHGKAVKRGASDTFIVVDMPIGTVGLSDEEDLKNALKLYQNTNANAVKVEGAHLTSFIQKATKMGIPVVSHLGLTPQSVGVMGYKLQGDTKTAAMQLIKDAKAMETAGAVVLVLEAIPSDLAREISQQLTIPVIGIGAGKDTDGQVLVYHDMLNYGVDRHAKFVKQFADFSSGIDGLRQYNEEVKAGTFPSENHTYKKRIMDEVEQHD
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHK_SYNJB
Sequence: MTSEKSQVLFPGAAPQVTTDLSNNVVLTTVNDLYNWAKMSSLWPLLYGTACCFIEFAAMLGSRFDFDRFGLLPRSSPRTADLIITAGTVTMKMAPALVKLYQQMAEPKYVIAMGACTISGGMFSSDSYTAVRGVDKLIPVDVYIPGCPPRPEAIMDAIVKLRKKIAAEDMRERGRLQQTHRYYTVKHNLKPVPEIITGKYLESETRQAPPPELAAAIGLPVPPALQTADFKQAEQQLKALQGGV
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit K, NAD(P)H dehydrogenase I subunit K, NDH-1 subunit K, NDH-K.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DPYL5_RAT
Sequence: MLANSASVRILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHFHQTFMNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETSLVEAYEKCRALADPKVCCDYALHVGITWWAPKVKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELYQVFHACRDFGAIPRVHAENGELVAEGAKEALDLGITGPEGIEISHPEELEAEATHRVITIANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTNAHATLTGLHYYHQDWSHAAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHRPFTTKQKAMGKEDFTKIPHGVSGVQDRMSVVWERGVVGGKMDENRFVAVTSSNAAKILNLYPRKGRIIPGADADVVVWDPEATKTISASTQVQGGDFNLYENMRCHGVPLVTISRGRVVYENGVFMCAEGTGKFCPLRSFPDIVYKKLVQREKTLKVRGVDRTPYLGDVAVVVNPGKKEMGTPLADTPTRPVTRHGGMRDLHESSFSLSGSQIDDHVPKRASARILAPPGGRSSGIW
What is the function of this protein?
Involved in the negative regulation of dendrite outgrowth.
What are the official names of this protein?
Dihydropyrimidinase-related protein 5, DRP-5, UNC33-like phosphoprotein 6, ULIP-6.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_TRIEI
Sequence: MFLFNILVLHGPNLNLLGLREPGIYGSVTLDNINRLLKQEAEAIGVKISISQSNHEGVLVDLIHSSSEQHQGILINAGAYTHTSVAIRDAISGINIPTVEVHLSNIYSREEFRHHSFIAPVAIGQISGFGSQSYLLGLKAIVNYLKNRGD
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: ASTL_HUMAN
Sequence: MEGVGGLWPWVLGLLSLPGVILGAPLASSCAGACGTSFPDGLTPEGTQASGDKDIPAINQGLILEETPESSFLIEGDIIRPSPFRLLSATSNKWPMGGSGVVEVPFLLSSKYDEPSRQVILEALAEFERSTCIRFVTYQDQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHTRADRDRYIRVNWNEILPGFEINFIKSQSSNMLTPYDYSSVMHYGRLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLKLYGCSPSGPRPRGRGSHAHSTGRSPAPASLSLQRLLEALSAESRSPDPSGSSAGGQPVPAGPGESPHGWESPALKKLSAEASARQPQTLASSPRSRPGAGAPGVAQEQSWLAGVSTKPTVPSSEAGIQPVPVQGSPALPGGCVPRNHFKGMSED
What is the function of this protein?
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization.  Plays a role in the polyspermy inhibition.  Probably acts as a protease for the post-fertilization cleavage of ZP2.  Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
What are the official names of this protein?
Astacin-like metalloendopeptidase, Oocyte astacin, Ovastacin, ZP2-proteinase.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Note=Probably exocytosed from cortical granules during post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages. Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS).
Protein: IHFB_ECOSE
Sequence: MTKSELIERLATQQSHIPAKTVEDAVKEMLEHMASTLAQGERIEIRGFGSFSLHYRAPRTGRNPKTGDKVELEGKYVPHFKPGKELRDRANIYG
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: SUB2_LODEL
Sequence: MSAENQEELLDYSDSEEIAVPTTTQAGEGESANDKEADKKGSYVGIHATGFRDFLLKPELLRAIGDCGFEHPSEVQQVCIPQSILGTDVLCQAKSGLGKTAVFVLSTLQQLDPVAGEISTLVICHTRELAYQIRNEYARFSKYMPDVKTEVFYGGTPVKRDIEKLKNKDTCPHIVVATPGRLHALVQEKAIRLNNVKSFVIDECDKVLESLDMRRDVQDIFRATPHQKQVMMFSATLSQDIRPVCKKFMQNPLEIYVDDEAKLTLHGLQQYYIKLEEKEKNRKLSDLLDSLEFNQVIIFVKSTQRANELNKLLCACNFPSIAVHSGLPQEERIERYKSFKEFNKRICVSTDVFGRGIDIERINLAINYDLPNEADQYLHRVGRAGRFGTKGLGISFVSTKEDEEVLEKIQSRFDVKITEFPEEGVDPSTYMNT
What is the function of this protein?
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus.  SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly.  May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase SUB2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: IBPKA_TYPIS
Sequence: MFSSTYLLAIIALAVSSVFAAGPTAVPLGTAGNYAILASAGVSTVPQSVITGAVGLSPAAATFLTGFSLTMSSTGTFSTSTQVTGQLTAADYGTPTPSILTTAIGDMGTAYVNAATRSGPNFLEIYTGALGGKILPPGLYKWTSPVGASADFTIIGTSTDTWIFQIAGTLGLAAGKKIILAGGAQAKNIVWVVAGAVSIEAGAKFEGVILAKTAVTLKTGSSLNGRILSQTAVALQKATVVQK
What is the function of this protein?
Binds to the surface of ice crystals (Ref. 1, PubMed:20030710, PubMed:27613857).  Inhibits growth of the ice crystals (PubMed:20030710).  Has antifreeze activity for survival under snow cover.  Has high thermal hysteresis (TH) activity, which is the ability to lower the freezing point of an aqueous solution below its melting point, and thus the freezing of the cell fluid can be prevented protecting the organism from ice damage (PubMed:20030710, PubMed:27613857).  The TH activity of this protein is 2. 0 degrees Celsius at 0. 11 mM (PubMed:27613857).
What are the official names of this protein?
Ice-binding protein K1-A, Antifreeze protein 8, AFP8, TAFP-3, TisAFP8.
What is the protein family that this protein belongs to?
Belongs to the ice-binding protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: YIDC_CHLMU
Sequence: MRMNKRTLLFVSLVSAAFLGCQIFFGYQDLKSCQDLAEKQRAISEQILASTEQLSVVPWTASAEESESVNQYAVRLGNRLLVLTKGGAHSEVHSKGTSWKLIDQTSTFGGILVSLYGEDGQEVLSKGGSVYLPNQQDALPVLVAEFRRNQEPLVFFGEYKNGKLSNKAGTIYGTSLVFLNTGNEFVPLGIYNSKEECVESLDLPMARAVVFADKENLTTSGSYYMLANEYMQVIVSQESGAIEGINLPFASDREGNKSIVNEIGFDRELAAGSPSEASFPGVQAIDSQRQNVSSVVGGYYPLLRRGTLSDTRKMVSPQYQALNIVSGRELSSPVATGFRVVSFDNKTLVLESGDGGIRKTYTLGEQPYAFDLEIQTTRGQEDLWITSGVPEVEIMSNAFVPAVKYHAVKKNKSDLINVKLPKAKDSLLVRNDASPQWILNSNGYFGVILTPKTPLPTGYASSFIPGNAVPTRLTQLSPKDQAYPASKYPGYTAMLPLPKEAGRYQFMVYAGPLSEPTLKALDRAHTNHKGESPEYVDAIAFRGFFSFITEPFAALLFIIMKFFQFLTGSWGISIILLTIVLKLVLYPLNAWSIRSMRRMQKLSPYIQDIQQKYKREPKRAQMEIMALYKVNKVNPITGCLPLIIQIPFLIAMFDLLKSSFLLRGASFIPGWIDNLTAPDVLFSWETPIWFIGKEFHLLPILLGIVMFAQQKISAIKRSGPVSDQQRQQEAMGTMMALLFTFMFYNFPSGLNIYWLSSMLLGVIQQWATNKILDEKHLQHEVIVNKKR
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins (By similarity).
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YEES_ECOLI
Sequence: MTPGERSLIQRALKTLDRHLHEPGVAFTSTRAAREWLILNMAGLEREEFRVLYLNNQNQLIAGETLFTGTINRTEVHPREVIKRALYHNAAAVVLAHNHPSGEVTPSKADRLITERLVQALGLVDIRVPDHLIVGGNQVFSFAEHGLL
What are the official names of this protein?
UPF0758 protein YeeS.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: NFYB3_ORYSJ
Sequence: MADGPGSPGGGGGSHESGSPRGGGGGGGGGGGGGGVREQDRFLPIANISRIMKKAIPANGKIAKDAKETVQECVSEFISFITSEASDKCQREKRKTINGDDLLWAMATLGFEDYIEPLKVYLQKYREMEGDSKLTAKAGDGSVKKDVLGSHGGSSSSAQGMGQQAAYNQGMGYMQPQYHNGDVSN
What is the function of this protein?
Component of the NF-Y/HAP transcription factor complex.  The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.  May regulate the expression of photosynthetic genes, and may be involved in chloroplast and amyloplast development.
What are the official names of this protein?
Nuclear transcription factor Y subunit B-3, OsNF-YB-3, Transcriptional activator HAP3B.
What is the protein family that this protein belongs to?
Belongs to the NFYB/HAP3 subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SDHD_BACMK
Sequence: MKEIEALKEQYPLVNNLIATEEVFWVNPNMEKYETAIKNSPLNEEHVKDAEERLKRFAPYIAKVFPETKETGGIIESPLVKISSMKQSLEKNYEQPILGELLLKCDSHLPISGSIKARGGIYEVLKHAEQLALQHGMLTEKDDYSILDSDRFRGFFAKYSIAVGSTGNLGLSIGIMSAKLGFNVTVHMSADAKQWKKDLLRSKGVNVIEYEADYSKAVEEGRLQADADPSCYFVDDENSHDLFLGYAVAASRLQKQLEELEIVVDEEHPLFVYLPCGVGGGPGGVAFGLKLLYKDNVHCFFAEPTHSPCMLLGLMTGLHDKIAVQDIGIDNVTDADGLAVGRPSGFVGKTMEPFLSGNYTVSDEELYRLLKELADTENIYLEPSALAGMIGPLNVCKAENEYLQKQQLTEKVKKGTHIVWGTGGSMVPEDVMNGYYKKGLELTCK
What are the official names of this protein?
Probable D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: RL16_MALP2
Sequence: MLEPKRTKYRRPHKVSYEGKAKGNKYVAFGEFGLMATNGAWISNRQIESARIAISKALGKTGKMWIRIFPHLSLTKKPLEVRMGSGKGSPEKWVAVVKAGTVMFEVANIPEEVARTALKNAGNKLSVNWKIVKKGEIAHD
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: YEJO_ECOLI
Sequence: MHQSGSVSLCRSAISVLVATALYSPIALASTVEYGETVDGVVLEKDIQLVYGTANNTKINPGGEQHIKEFGVSNNTEINGGYQYIEMNGAAEYSVLNDGYQIVQMGGAANQTTLNNGVLQVYGAANDTTIKGGRLIVEKDGGAVFVAIEKGGLLEVKEGGFAFAVDQKAGGAIKTTTRAMEVFGTNRLGQFDIKNGIANNMLLENGGSLRVEENDFAYNTTVDSGGLLEVMDGGTVTGVDKKAGGKLIVSTNALEVSGPNSKGQFSIKDGVSKNYELDDGSGLIVMEDTQAIDTILDKHATMQSLGKDTGTKVQANAVYDLGRSYQNGSITYSSKAISENMVINNGRANVWAGTMVNVSVRGNDGILEVMKPQINYAPAMLVGKVVVSEGASFRTHGAVDTSKADVSLENSVWTIIADITTTNQNTLLNLANLAMSDANVIMMDEPVTRSSVTASAENFITLTTNTLSGNGNFYMRTDMANHQSDQLNVTGQATGDFKIFVTDTGASPAAGDSLTLVTTGGGDAAFTLGNAGGVVDIGTYEYTLLDNGNHSWSLAENRAQITPSTTDVLNMAAAQPLVFDAELDTVRERLGSVKGVSYDTAMWSSAINTRNNVTTDAGAGFEQTLTGLTLGIDSRFSREESSTIRGLIFGYSHSDIGFDRGGKGNIDSYTLGAYAGWEHQNGAYVDGVVKVDRFANTIHGKMSNGATAFGDYNSNGAGAHVESGFRWVDGLWSVRPYLAFTGFTTDGQDYTLSNGMRADVGNTRILRAEAGTAVSYHMDLQNGTTLEPWLKAAVRQEYADSNQVKVNDDGKFNNDVAGTSGVYQAGIRSSFTPTLSGHLSVSYGNGAGVESPWNTQAGVVWTF
What are the official names of this protein?
Putative uncharacterized outer membrane protein YejO.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein.
Protein: GSLG1_CRIGR
Sequence: MFRLSAALQLLLLAATGAQNNHGQVQVPGANIGPLLGQAEGGSPAGQQLLQLSQQQKQPPQQQQQQQPAFPAGGPPARRGGAGPGGTGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVCKSTISEIKECAEEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINLLKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEEKEPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVIRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSELMPPGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLAVECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHRVSLKCRKQLRVEELEMTEDIRLEPDLYEACKSDIRGYCSTVQYGNAQIIECLKENKKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMITKRQITQNTDYRLNPVLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEIANLCAEEAAAQEQTGQVEECLKVNLLKIRTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNYILSVISGSICILFLIGLMCGRITKRVTRELKDR
What is the function of this protein?
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
What are the official names of this protein?
Golgi apparatus protein 1, E-selectin ligand 1, ESL-1, Golgi sialoglycoprotein MG-160, Latent TGF-beta complexed protein 1, LTCP-1.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Golgi medial cisternae. Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.
Protein: ENV_HV1V9
Sequence: METQRNYPSLWRWGTLILGMLLICSVVGNLWVTVYYGVPVWKEAKTTLFCASDAKAYDTERHNVWATHACVPTDPNPQEMVLENVTETFNMWVNDMVEQMHTDIISLWDQSLKPCVKLTPLCVTLDCSSVNATNVTKSNNSTDINIGEIQEQRNCSFNVTTAIRDKNQKVHALFYRADIVQIDEGERNKSDNHYRLINCNTSVIKQACPKVSFEPIPIHYCAPAGFAILKCNGKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEVEEVIIRSKNITDNTKNIIVQLNEPVQINCTRTGNNTRKSIRIGPGQAFYATGDIIGDIRRAYCNISGKQWNETLHKVITKLGSYFDNKTIILQPPAGGDIEIITHSFNCGGEFFYCNTTKLFNSTWTNSSYTNDTYNSNSTEDITGNITLQCKIKQIVNMWQRVGQAMYAPPIRGNITCISNITGLILTFDRNNTNNVTFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTEARRRVVEREKRAVGMGAFFLGFLGAAGSTMGAASITLTVQARQLLSGIVQQQSNLLRAIQAQQHMLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTNVPWNSSWSNKSLDEIWDNMTWMEWDKQINNYTDEIYRLLEVSQNQQEKNEQDLLALDKWANLWNWFSITNWLWYIRIFIMIVGGIIGLRIVFAVLSIVNRVRQGYSPLSLQTLIPNQRGPDRPREIEEEGGEQDRDRSIRLVNGFLPLVWEDLRNLCLFSYRRLRDLLSIVARTVELLGRRGWEALKLLGNLLLYWGQELKNSAISLLNTTAIAVAEGTDRIIELVQRAWRAILHIPRRIRQGFERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: SARA_STAA8
Sequence: MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL
What is the function of this protein?
Global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner.  In a strain-dependent manner plays a role in multidrug resistance mechanism.  Is required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus.  Acts as a transcriptional activator of the genes encoding, among others, for fibronectin binding proteins (fnbA and fnbB), hemolysins (hla, hld, hlgB and hlgC), serine proteases (splA, splB, splD and splF) and of the bap gene, which is essential for biofilm development in some strains.  Negatively regulates the expression of the genes for protein A (spa), lipase (lip), thermonuclease (nuc), immunodominant staphylococcal antigen B (isaB), staphylococcal serine and cysteine proteases (sspA and sspB), staphostatin B (sspC), metalloprotease aureolysin (aur) and collagen adhesin (cna).  Probably activates the development of biofilm by both enhancing the ica operon transcription and suppressing the transcription of either a protein involved in the turnover of PIA/PNAG or a repressor of its synthesis, whose expression would be sigma-B-dependent.
What are the official names of this protein?
Transcriptional regulator SarA, Staphylococcal accessory regulator A.
What is the protein family that this protein belongs to?
Belongs to the SarA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_ANAMF
Sequence: MKLNELFAGLPKRRRLKVLGRGLGCGKGKTSGRGHKGQKARSGCAVNGFEGGQQPIFTRLPKRGFRSMSRARYEIVNIGALQRLISEKKIVDASNISKELMAELGMIPSPMSKVKILGKGALKAKVGISYDAVSKAAWEESLLTEGLSDS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: KDSB_SHESW
Sequence: MNVILLIPARYGSSRFPGKPLAPINGKPMIQHVYERASLAKGLTNIYVATDDERIKATVEGFGGKVVMTSPDAASGTDRINEAIKLLGLKDDDLVINVQGDQPLIDPTAIEQLINLFERQPGEFEMATLGYEIVNKADIDDPMQVKMVFDNNYYALYFSRSRIPFGRDTQDYPVFKHLGIYAYTSKFVQTFAALPLGRLEDLEKLEQLRALEHGHKIKIAISASNSLEVDRPEDIHKCEQRLAAG
What is the function of this protein?
Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus.
What are the official names of this protein?
8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase, CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_METCA
Sequence: MAVSKEDILETISNMTVMEIVDLISAMEEKFGVSAAAAVAVAPVAAGAAAPAVEEKTEFDVVMTSFGANKVNVIKAIREITGLGLKEAKDLVEGVPSTVKEGISKAEADDIKKKLEEAGAAVDVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: YCX2_CHLMO
Sequence: MDFYNICCKYLKEIELTREDYSADRNSPQYNLFCSHHINPKFNKGGDEPENLVLLHYFEHAYVHLFRWLITDNPRDLGGFTSAMNAKERRELQIEKRRENPPKLTLPPLPPPAEERKKPAKTAKAIRAGKAVGSKYQLQSLKRANPFTMFMANLVLKFINNNGIEVIHKPSDNIKDVSVNSASAIGRALNNVYPTETLTNSPDGISKLLKGTNKIVQNWRIDSLFIDDFEYEITQEVLLKYQDLFETLTTYFSENQELSILELTKSMADIRNSNPKEIALIQKMFTFIKKWSFLIKSLSEGKADDEIDLPTD
What are the official names of this protein?
Uncharacterized 35.9 kDa protein in psbA intron 2.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TCRY_MYCTU
Sequence: MGITAATEMALRRHLVAQLDNQLGGTSYRSVLMYPEKMPRPPWRHETHNYIRSGPGPRFLDAPGQPAGMVAAVVSDGTTVAAGYLTGSGSRAALTSTGRSQLERIAGSRTPLTLDLDGLGRYRVLAAPSRNGHDVIVTGLSMGNVDATMLQMLIIFGIVTVIALVAATTAGIVIIKRALAPLRRVAQTASEVVDLPLDRGEVKLPVRVPEPDANPSTEVGQLGSALNRMLDHIAAALSARQASETCVRQFVADASHELRTPLAAIRGYTELTQRIGDDPEAVAHAMSRVASETERITRLVEDLLLLARLDSGRPLERGPVDMSRLAVDAVSDAHVAGPDHQWALDLPPEPVVIPGDAARLHQVVTNLLANARVHTGPGTIVTTRLSTGPTHVVLQVIDNGPGIPAALQSEVFERFARGDTSRSRQAGSTGLGLAIVSAVVKAHNGTITVSSSPGYTEFAVRLPLDGWQPLESSPR
What is the function of this protein?
Member of the two-component regulatory system TcrY/TcrX.  Activates TcrX by phosphorylation.
What are the official names of this protein?
Probable sensor histidine kinase TcrY.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: KDPC_SODGM
Sequence: MMKLLRPALSVFFLLVLVTAVAYPLVVTGLAQWWFPGAAQGSLVTQDGQPCGSVLIGQTFTRAGYFQGRPSATADTPYNAPASSGSNLAVSNPALDDAVKQRVTALLQANPHADAPVPVELVTASASGLDPHISPAAALWQIPRVAEARHLPQAELRRLVDDNTTRPLLYFIGEPVVNVLKLNMALDARQKG
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.