PharMolix/UniProtQA huggingface dataset:
Protein: SOP12_ARATH
Sequence: MRNTISSKMGQVLIVLLLLCTVLCRTESALPSGQHSVLLTGRRLMGSGASGPVRSSQSSQAGGRFNDADPIAIDYGKY
What is the function of this protein?
Brassicaceae-specific phytocytokine (plant endogenous peptide released into the apoplast) perceived by MIK2 in a BAK1/SERK3 and SERK4 coreceptors-dependent manner, that modulates various physiological and antimicrobial processes including root growth prevention, phospholipid signaling pathway activation (e. g.  accumulation of phosphatidic acid (PA), but transient reduction of phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels) and reactive oxygen species (ROS) response regulation (PubMed:30715439, PubMed:33514716, PubMed:34535661).  Moderates primary root growth, and regulates root meristems and cell elongation; this root growth regulation is associated with the modulation of ROS metabolism and alteration of cell wall structure, and depends on variations in many genes expression (PubMed:34535661, PubMed:35639812).  Promotes ROS (e. g.  superoxide anion O(2) and hydrogen peroxide H(2)O(2)) production and MAPK (e. g.  MPK3, MPK4 and MPK6) activation in a MIK2-dependent manner, thus leading to the up-regulation of immune-related marker genes (e. g.  WRKY30, WRKY33 and CYP81F2) (PubMed:34535661, PubMed:35639812).  Involved in biotic and oxidative stress responses; acts as a negative regulator of defense against necrotrophic pathogens such as the bacteria Erwinia amylovora and the fungus Alternaria brassicicola (PubMed:30715439).  Able to prime defense responses against the pathogenic bacteria Pseudomonas syringae pv.  tomato DC3000 (PubMed:30715439).  Contributes to the triggering of defense responses toward generalist herbivores such as Spodoptera littoralis, probably via the activation of jasmonate and indole glucosinolate biosynthesis (PubMed:35401621).  Triggers the expression of several PROSCOOP genes (e. g.  PROSCOOP3, PROSCOOP7, PROSCOOP12 and PROSCOOP13) (PubMed:30715439).
What are the official names of this protein?
Serine rich endogenous peptide 12, AtSCOOP12, Phytocytokine SCOOP12, Precursor of serine rich endogenous peptide phytocytokine 12.
What is the protein family that this protein belongs to?
Belongs to the serine rich endogenous peptide (SCOOP) phytocytokine family.
Protein: DPOL_RHCM6
Sequence: MFFNPYLSGARKPPNLVAKRSVAKTFLEIVPRGAMHDGQSGLIKHKTGRGAIMFYRDIKHVLENDMAWPCPLPAPPPSIEAFARRLMGPLKFHTYDQVDGVLTHDTQECLSPRYRHHITPSGNVLRFFGATEQGHSICVNVFGQRSYFYCEYADGDLLRDLLASVSDLVSEPRMAYALTITPVQKMSIYGYGTSPIPNLFRVSISNWSMAKKIGEYLLENGIPVYEIRVDPLTRLVIDKKMTTFGWCCVHRYEWRTHKSSTCDFEIDCDVADIMAVSDDTSWPVYRCLSFDIECMSASGGFPAAEQTDDIVIQISCVCYNTGGTGCEENTVFGTSGLHLFTIGSCAPLAGVDVYEFPSEYEMLLGFLIFFQRYSPCFVTGYNINSFDFKYILTRLEFVYKLSPGPYSKLPAQGRFSMYSPLKKFVTTTTTKVFISGTVVIDMYPVCMAKTSSPNYKLNTMAELYLKQQKEDMSYKDIPVKFISGCEGRAQVGKYCVQDAVLVKDLFNTINFHYEAGAIARLARIPMRRVIFDGQQIRIYTSLLDECACRDFIMPNHKGADNSSEPTDVSYQGATVFEPEVGYYSDPVVVFDFASLYPSIIMAHNLCYSTFVAPGGESPPESDVLTVELESGLSYRFVKNTVRNSVLSELLTKWVSQRRAVRETMRSCHDPVKRMLLDKEQLALKVTCNAFYGFTGVVNGMMPCLPIAASITRIGRDMLMRTSQFVEENFAEPCFLHNFFNREDYSGDPVAVKVIYGDTDSVFVCYRGVTAAALIERGPSLAHYITQCLFVDPIKLEFEKVFGSLMMICKKRYIGKIVGETELSMKGVDLVRKTSCEFVKNVTRDIIQLLFDDPEVSRAAVQLSRLTLDELKMQGVPPGFGRVIQRLSQARDELYTSRARVEELVLSSVLSKDVSLYKQSNLPHIAVIKRLAARSEELPVVGDRVFYVLTAPVDGRSSGVRNYEIAEDPTYVREHGVPIHADKYFDQVIKSVTNVLSPVFPPQTLRKDKFLLGILPHRIYLEPSFLPYCVKASEHC
What are the official names of this protein?
DNA polymerase catalytic subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: CDVA_SULAC
Sequence: MGIPVEVLTKFIGQKVKDVYGRDAGVIVHVYTEIDGTITGIELFKGEEIKTYSPNSVKVDGDSVVILPDWKTDSLKVLGQMEKIRKRQRALEELYSRQEIPKSTYEDMKRKLDSELLKIRDEHSRLKGRLKDRLNSIEDQVAQIDRAMIALKINYISGEIPELAYKNSMEILRLSRDSYALERDDIKKTLDKLDGLDKEVIELKPSASLNTSTEQSNKNEGNKSEVSVPIPVRVINTL
What is the function of this protein?
Part of a cell division machinery (PubMed:18987308, PubMed:21255729).  The CdvA, CdvB and CdvC proteins polymerize between segregating nucleoids and persist throughout cell division, forming a successively smaller structure during constriction (PubMed:18987308).  CdvA is a membrane interacting protein that recruits ESCRT-III homologs to the membrane (PubMed:21255729).
What are the official names of this protein?
Cell division protein A.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Cell membrane; Peripheral membrane protein. Note=Forms, with CdvB, colocalized band- like structures between segregating nucleoids.
Protein: RPOA_LACCB
Sequence: MIEFEKPNITKVDESTNYGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAISSIQIDGVLHEFSTIDGVLEDVTQIILNIKKLALKMNTDEDKNIEIDVNGPAKVTAADIVADPDVEVLNPEQYICTVADGGHFHVRMTVKKGRGYVAADQNKSDDMPIGVLPIDSIFTPISRVNYQVESTRVGRRNDFDKLTLDVWTNGSISPREAISLAAKILTEHLDIFVNLTDEAKNAEIMVEKEETHKEKMLEMTIEELDLSVRSYNCLKRAGINTVQELTNKTEADMMKVRNLGRKSLEEVKNKLADLGLGLRKED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: Y4390_HAEIG
Sequence: MAGHSKWANIKHRKAAQDAQRGKIFTKLIRELVTAAKIGGGDVSANPRLRAAVDKALSNNMTRDTINRAIDRGVGGGDDTNMETKIYEGYGPGGTAVMVECLSDNANRTISQVRPSFTKCGGNLGTEGSVGYLFSKKGLILIAEADEDALTEAAIEAGADDIQPQDDGSFEIYTAWEDLGSVRDGIEAAGFKVQEAEVTMIPSTTVDLDIETAPKLLRLIDMLEDCDDVQNVYHNGEICDEVASQL
What are the official names of this protein?
Probable transcriptional regulatory protein CGSHiGG_04390.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KARG_ANTJA
Sequence: MADPETAAKFKSKNAFPDPLNDPKCNPKSLVKKYLTPKVFESLKNKKTKLGITLWDCINSGVVNLDSGVGVYAGDEESYTLFGPLFDAIIEDYHSPYKLATGHNSDMNPAHVKAPDLDPANRYIRSTRIRVARSLKGYGLAPGVTKAHRLEIEKKVVGVLTSLTGDLAGKYYPLSGMDEKTRQQLVDDHFLFKKGDRFLEAAGINKEWPEGRGIYHNNDKTFLVWLNEEDHLRIISMEKGSDIGSVFSRLCRAVNEIDKKLGFQHTKKHGYLTSCPSNLGTGMRASVHVKIPHAKEHPDFENILTKYHIQARGIHGEHSESTGEDAGVYDISNRRRLGLSEVQCVQDMYDGVKALMELEKEAIAKKRSVFPEVLKNPEVKSLLRKYLTPELFDSLKDKKTAKGISLYDCINSGVENLDSSCGVYAGDEECYTLFAPLFDKIVEDYHSPYKLANKHTSDMNPEKVDAPNLDPEGTYIRSTRIRVARNVKGYALTPGLTRNERLDIERKVVGVLSSLTGDLAGQYYPLTGMDEATRQKLVNDHFLFKKGDRFLEAAGVNKLWPEGRGIFHNNDKTFLVWINEEDQLRIISMEKGSDIGSVFGRLCRAVNEIDKQLGFQHTDAHGYLSGCPTNLGTGMRASVHVKIPKASAHPDFQKICDEFHIQARGIHGEHSVSTGEDAGVFDISNRRRLGLSEVQCVQDMYNGVKKLLEIEKSTK
What are the official names of this protein?
Arginine kinase, AK.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: DSZC3_RHOER
Sequence: MTLSPEKEHVRPRDAADNDPVAVARGLAEKWRATAVERDRAGGSATAEREDLRASALLSLLVPREYGGWGADWPTAIEVVREIAAADGSLGHLFGYHLTNAPMIELIGSQEQEEHLYTQIAQNNWWTGNASSENNSHELDVKVSATPTEDGGYVLNGTKHFCSGAKGSDLLFVFGVVQDDSPQQGAIIAAAIPTSRAGVTPNDDWAAIGMRQTDSGSTDFHNVKVEPDEVLGAPNAFVLAFIQSERGSLFRPIAQLIFANVYLGIAHGALDAAREYTRTQARPWTPAGIQQATEDPYTIRSYGEFTIALQGADAAAREAAHLVQTVWDKGDALTPEDRGELMAKVSGVKSLATNAALNISSGVFEVIGARGTHPRYGFDRFWRNVRTHSLHDPVSYKIADVGKHTLNGQYPIPGFTS
What is the function of this protein?
Catalyzes the first step of the '4S' desulfurization pathway that removes covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds.  Sulfur dioxygenase which converts DBT to DBT-sulfone (DBTO2 or DBT 5,5-dioxide) in a stepwise manner.
What are the official names of this protein?
Dibenzothiophene monooxygenase, DBT monooxygenase, DBT-MO.
What is the protein family that this protein belongs to?
Belongs to the DszC flavin monooxygenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CU92E_CONCL
Sequence: KKGVTQREDDRTFPCNSGRCACQPLDSYSYTCQSPSSSTANCKNNVCVSEADW
What is the function of this protein?
Probable neurotoxin with unknown target.  Possibly targets ion channels.
What are the official names of this protein?
Conotoxin Cal9.2e.
What are the subcellular locations of this protein?
Secreted.
Protein: PUR7_EXIS2
Sequence: MQPLYEGKAKRLYTTQDQDVLRIVYKDEATAFNGEKKAEFAGKGELNNRLTSHFFEVLAAAGIPTHFIEQTSEREQLVRRVTIIPLEVVVRNVVAGSLSKRLGIEEGTVLETPIVEFYYKDDSLGDPLVTPAHINLLKIATTEELSLLEQEANRVNDVLRPYFDEKGITLIDFKLEYGKTPAGEILLADEISPDTCRLWDKETGEHLDKDVFRRNIGSLIDTYQTLFNRLGGNGQ
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: SYFA_CHLPM
Sequence: MEKSISSLQQQINAAPLNSEADIESFRLLYTVRKGLIAALFSQLKSVDPTDRPRIGNLLNQLKESAEARIAEAAESISHHEESSQPVIDLTLPGRVSFTGSEHPVQKVLGEMKRIFSAMGFAMATGPELELDSYNFDMLNFPPDHPARDMQDTFFIKRNGNEDDVLLRTHTSPVQVRVMLEEPPPIRVICPGKVYRNEAISSRSYCVFHQLEGLYIDKGVTFADLKATIYSFAHQMFGSDVKLRFRPSFFPFTEPSAEVDVTCYLCGGKGCKVCKKSGWLEIMGCGMVHPNVIQNCGIDPEVWSGYAFGMGVDRTVLLHYKIDDIRLLFENDIRMLRQFTA
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VITH2_ORYSJ
Sequence: MARAQWLRAAVLGANDGLVSVASLMIGIGAVNENNKAMLVSGLAGLVAGACSMAIGEFVSVYAQYDIEVTQIERDGDIDGADAAAAREKLPSPTQAAFASALAFAIGGLLPLLTSGFIKPWGPRVGVVCAASSVGLAGFGAAGGYLGGANMVRSGTRVLLGGWLAMLITYAVLRLFATIFHGMNISSSA
What is the function of this protein?
Probable vacuolar iron transporter that may be involved in the regulation of iron distribution throughout the plant.
What are the official names of this protein?
Vacuolar iron transporter homolog 2, Protein NODULIN-LIKE 2.
What is the protein family that this protein belongs to?
Belongs to the CCC1 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: NCAP_HIRRV
Sequence: MANLKEEFAGLRGVKGGALEDSGTEYDPTKINLTLYGTDKLYTLAIIKRAVSQVGGSQTNKALGILCAFVTSENNPDMTDAAVKLLVDMRFKVDVVPVDDRLGDNLDDPNSKLAEVLTEENMVDLVKGLLFTCALMVKYDVDKMATYCQQKLERLANSQGLNELTLISTSRAVLARIGAAVRPGQKLTKAIYGIILINLMDPATAARAKALCAMRLSGTGMTMVGLFNQASKNLGAPPADLLEDLCMKSIIDSARRIVKLMRIVADVEDMTAKYAIMMSRMLGDGYFKSYGINENSRITCILMNINEQYDEGTTGGLAGVRVSPPFRKLATEIARLLVKKYDGNGSAGPGASDLVRQAEQAAQETEGEDDKYDEEGEEDGGEGEGGEDEEYY
What is the function of this protein?
Encapsidates the genome, protecting it from nucleases.  If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA.  Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation.  The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace.  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication.  Protein N binds protein P in the NC through a different interaction, and can be phosphorylated.  Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N.  During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
What are the official names of this protein?
Nucleoprotein, NP, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the novirhabdovirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: KHSE_ECOLI
Sequence: MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPETAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.  Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group.  Neither L-threonine nor L-serine are substrates of the enzyme.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCNP_MOUSE
Sequence: MADGKAGEEKPEKPQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEDEAADLPTKPTKMSKFGFAIGSQTARKASAISIRLGASKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN
What is the function of this protein?
May be involved in cell cycle regulation.
What are the official names of this protein?
PEST proteolytic signal-containing nuclear protein, PCNP, PEST-containing nuclear protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: PA2GD_MOUSE
Sequence: MRLALLCGLLLAGITATQGGLLNLNKMVTHMTGKKAFFSYWPYGCHCGLGGKGQPKDATDWCCQKHDCCYAHLKIDGCKSLTDNYKYSISQGTIQCSDNGSWCERQLCACDKEVALCLKQNLDSYNKRLRYYWRPRCKGKTPAC
What is the function of this protein?
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular lipids, exerting anti-inflammatory and immunosuppressive functions (PubMed:10531313, PubMed:23690440, PubMed:26392224, PubMed:10455175).  Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (By similarity).  In draining lymph nodes, selectively hydrolyzes diacyl and alkenyl forms of phosphatidylethanolamines, releasing omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoate and docosahexaenoate that are precursors of the anti-inflammatory lipid mediators, resolvins (PubMed:23690440).  During the resolution phase of acute inflammation drives docosahexaenoate-derived resolvin D1 synthesis, which suppresses dendritic cell activation and T-helper 1 immune response (PubMed:23690440, PubMed:27226632).  May act in an autocrine and paracrine manner.  Via a mechanism independent of its catalytic activity, promotes differentiation of regulatory T cells (Tregs) and participates in the maintenance of immune tolerance (PubMed:19564598).  May contribute to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance.  Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541).
What are the official names of this protein?
Group IID secretory phospholipase A2, GIID sPLA2, sPLA2-IID, PLA2IID, Phosphatidylcholine 2-acylhydrolase 2D, Secretory-type PLA, stroma-associated homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
[Isoform 1]: Secreted. Cell membrane. Note=Localizes to cell membrane likely through binding to heparan sulfate proteoglycans. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
Protein: F16PC_CLOTE
Sequence: MTLYDEDNINLIKDDLRYLKLLSTKYHNIPSACSEIINLQAILNLPKGTEHFISDIHGEYESFTHMLKNASGVIKRKLDDIFGTSLMDKDKDSLATLIYYPKEKLEILKESNNDLEEWYKVTLYRLIQVCKSVSSKYTRSKVRKALPKNFSYIIEELLNEQADRVNKQEYYSGIINTIVDIGCADSLIIEISKVIQKLVVDRLHIIGDIYDRGPGAEIIMDALMDHHSMDIQWGNHDILWMGAASGSKACTANVLRISLRYANLSTVEDGYGINLLPLATFAMKYYGNDPCESFIPKALDKMLDESDKNLYAKMHKAISIIQFKLEGQKIKRHPEFKLENMLLLDKINFDDGTITFEGSTYKLNDTNLPTIDPKNPYKLTKEESELIEKLQGSFLNSEKLQKHIRFMYSIGSLYLVYNSNLLFHGCIPLNEDSSFRTLNICNKEYSGKSLLDLFDKYAREAYYYKDDDNVKNYAMDMMWYLWCGPISPLFGKHKMTTFERYFIDDKKTHKEIKDPYYTYRDSEELCNRIFEEFQLDLEKSHIINGHIPVKTKNGESPVMANGKLLVIDGGFCKAYQPQTGIAGYTLIYNSYGFLLSSHEPFESTKKAIEEEQDILSSTVILENSVTRKRVMDTDIGKELKEQIKNLKKLLVAYRKGLIQENI
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 3, FBPase class 3, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 3 family.
Protein: NU2C1_EUCGG
Sequence: MIWHVQNENLILDSTRIFMKAFHLLLFDGSFIFPECILIFGLILLLMIDSTSDQKDIPWFYFISSTSLVMSITALLFRWREEPMIIFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGILIALLFITVGIGFKLSLAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNGGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLHLFWCGWQAGLYFLVSIGLLTSVISIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 A, chloroplastic, NAD(P)H dehydrogenase, subunit 2 A, NADH-plastoquinone oxidoreductase subunit 2 A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: AMBB_PSEAE
Sequence: MQERHGLPLRSFSSGKALTAGRAVRPEVAQERRYLQGAPLGLELPGRIALRDPHCAWQWFEPEAAAEAFPAAHWLAAFLVLLGRYGNEEITLGFPEPITVRGRQAPALLRSSYRAMESSAERSARLAEELDDARRQLSADGQERAALAGRCAVQVLAARPTASSPGWLALVLAADGSVGLALRDPQYDELRRIAGHLARLARGLVDAQACVGRLPWLDADEERRLQALRSEPQAAPSRGVLHHLFEAQARRTPQRIAVHAADRSLSYAELERESAALAVRLRAAGVAPEQRVGVCLRRDSGLLVGLLGVLRAGGCYVPLDPAYPEERVAYMLDDADCLLVLVDASTRERVAALGRPCLTLEEGGDQANDLALPASEVGADHLAYIIYTSGSTGRPKGVAIEHGSAHAFLRWAGQHYAAEEWSGVLAATSVCFDLSVYELFGTLAEGGTLHLVENLFSLPDYPRRDEISLLNTVPSVCAALLALGDLPGGVRTLNLAGEPLRGHLVRQIRGQPQVRRLVNLYGPTEDTTYSTVHELDLHAEALDEPPIGRPLPGTTVEVLDGFEAPLPLGVAGELYLGGIGLARGYFGKPEQTAERFRVDPGSGERRYRTGDRVRMREDGVLEHLGRLDDQVKFNGFRIELGEIASCLASFPGVSEACAMLTEDSAGLRRLVGYLAAPFAPPLQALNEHLGQSLPHYMLPSAFVVLAELPKTLNGKIDRKALPRPQATGAEPQALPSDPLEQALHQAWQAQLGAPPRAGQGFYAAGGDSLRAVHLLATLRQRLSRRVPLQAFAGGPATPEALLELLRQAAPEGDEPEPSAGAAGLSLAERRLWVAQQLAPEDTSYNLLAHLRIVGATADAIEQALRQLLERHVALRRRVETGVDGPQPHALAAHAVPLQRLLASDAVHAERLLEDGVRREGARVFDLAHEAPARLLLVVTRDSARADLLLSVHHYAFDDVSLAVFAAELKTLLDGGRLGVLASTPEQVAARERAALASGRLDRVAERWAERLLPLAKAPGAAPARPEESGGRAGQRLALPVSAAVHAACRALAERTSVSPFSAALQAFAEVLGAELGVDDLLVGVALAGRSRLEMQGLVGCFVNLLPLAVGLRPEQSVEWRLRQVGHDLLELLEHQDVPLECVTQALRQRGASGLPIRIACGAHNGRAAPAVDAGVRVEADFIPVPGARLDLTLWLEDQPQGWLAVWTGVSAIFDLHRIERLHQAWERRLLANAGEPISKRMSPEGCNAS
What is the function of this protein?
Involved in the biosynthesis of the antimetabolite L-2-amino-4-methoxy-trans-3-butenoic acid (AMB), a non-proteinogenic amino acid which is toxic for prokaryotes and eukaryotes (PubMed:20543073, PubMed:25814981).  Adenylates L-alanine and loads it onto its peptidyl carrier domain via a thioester linkage to the phosphopanthetheine moiety.  In addition, loads activated L-Ala in trans onto the second carrier domain of AmbE (PubMed:25814981).  Can also activate L-Ser, Gly and D-Ala, albeit to a lower extent (PubMed:25814981).  The condensation domain of AmbB probably condenses the activated L-Ala and the L-Glu loaded on AmbE to form a L-Glu-L-Ala dipeptide at the first carrier domain of AmbE (PubMed:25814981).
What are the official names of this protein?
AMB antimetabolite synthase AmbB, L-alanine--[L-alanyl-carrier protein] ligase, Nonribosomal peptide synthase AmbB.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: PDXB_PECCP
Sequence: MKILVDENMPYARELFSRLGDVQAVPGRPLPRDLLAGADALMVRSVTKVNADLLSGSAVKFVGSATAGTDHVDDTWLNANGIAFSAAPGCNAIAVVEYVFSSLLMLAERDGFQLRDKTVGIVGVGNVGRRLDARLKAWGVKTLLCDPPRADRGDAGDFLPLETLVRDADILTLHTPLYLDGPYRTHHLVDASVLDAFADGRILINACRGPVVDNAALLEALQRGKKLSVILDVWEPEPELSTDLLARVDIGTAHIAGYTLEGKARGTTQVFEAWSEFIGTPQQVALSSLLPEPEYAEVTLTVPLDEALLKRLVHLVYDVRRDDALLRHVAHQEGEFDRLRKHYQERREWSSLHVICADADSADCLNALGFTASVRGAR
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STK36_MOUSE
Sequence: MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRWPSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGSDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILRQACKLMAEEAKQKEDQNAGSALEQEDGLCKVTPSTAPVPGLKATPQESSLLAGILASEMKNNWEDWGAGEAPRTSRENHINLECEQGFPEPRPEAMGRQSTDVVDPENEEPDSDDEWQRLLETSEPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGVLDGVSHLLPVLRILSSLLSSCNDSVLLYSFCQEAGLPELPLSLLRYSQESSSIQQQPWYGALLRDLVAVVQAYFSCTFNLERSQTGDSLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMCFAVLCEAVDGNSWAVSKAFYSSLLTTQRAVLDGLLHGLTVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQLRPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLALESLLMLVQGKVKVADWEESTEVALYLLSLLVFRLQDLPSGMEKLGSEVATLFTHSHVVSLVNAAACLLGQLGQQGVTFDLQPREWIAAAAHALSAPAEVRLTPPYSCGFYDGLLILLLQLLMQVQGKPGLIRDVVGSEVWTILWHRFSMALRLPEEVSAQEDDLLLSSPSSLEPDWTLISPQGMAALLSLAMAIFTQESQLCLSHLSQHGSVLMLTLKHLLSPSFLHHLSQAPQGPEFLPVVVLSVCKLLCFPFALDVDADLLVGVLADLRASEVVVCLLQVCCHHLSLLQAELPIGLLTRLALTDSASLKQFVNTVATSSRAIISFLSVVLLSDQPLMISDLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQHSMALRGALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDGIRRNAASALGNLGPEGLGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLQQESCIHQVLVSLGASEKLALLSLGNQLLPNSSNRPASVRHCRKLIQLLRPTHST
What is the function of this protein?
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors.  Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization.  GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur.  Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function.  Essential for construction of the central pair apparatus of motile cilia.
What are the official names of this protein?
Serine/threonine-protein kinase 36, Fused homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, cilium axoneme. Note=Low levels also present in the nucleus.