PharMolix/UniProtQA huggingface dataset:
Protein: G3BP1_PONAB
Sequence: MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVSNDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETVPEDAQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFFQSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ
What is the function of this protein?
ATP- and magnesium-dependent helicase that plays an essential role in innate immunity.  Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS.  Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA.  In addition, plays an essential role in stress granule formation.  Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends.  Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency.  Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.  Phosphorylation-dependent sequence-specific endoribonuclease in vitro.  Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR.
What are the official names of this protein?
Ras GTPase-activating protein-binding protein 1, G3BP-1, ATP-dependent DNA/RNA helicase G3BP.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Perikaryon. Cytoplasm, Stress granule. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells. Cytosolic and partially nuclear in resting cells. Recruited to stress granules in response to arsenite treatment. The unphosphorylated form is recruited to stress granules. HRAS signaling contributes to this process by regulating G3BP dephosphorylation.
Protein: PYRG_STAAB
Sequence: MTKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITNEIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQIRSDLGRENVMYVHCTLLPYIKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECRDADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKYVSLQDAYLSVVESLKHAGYPFAKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRASEGKISAIKYARENNVPFFGICLGMQLATVEFSRNVLGLEGAHSAELDPATPYPIIDLLPEQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMVISGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: IHFB_HAEDU
Sequence: MTKSELIEKLIALNPSLPEKAVEDGVKDILENIMLTLEQAKRVEIRGFGSFSLHYRQPRIGRNPKTGASVKLDAKYVPHFKAGKDLKERVDLV
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: RSMF_SALSV
Sequence: MAQHAVYFPDAFLTQMREAMPSTLSFDEFISACQRPLRRSIRINTLKISVADFLALIAPYGWSLTPIPWCHEGFWIERDDEEALPLGSTAEHLSGLFYIQEASSMLPVAALFADDNHPQRVMDMAAAPGSKTTQIAARMGNRGAILANEFSASRVKVLHANISRCGIANTALTHFDGRVFGAALPEMFDAILLDAPCSGEGVVRKDPDALKNWSPESNLDIAATQRELLDSAFHALRPGGTLVYSTCTLNRQENEAVCLWLKETYADAVEFLPLGDLFPDADRALTPEGFLHVFPQIYDCEGFFVARLRKMSSLPAMPAPGYKVGAFPFTPLKGREALHVTQAANAVGLLWDENLHLWQRDKEVWLFPAEIESLIGKVRFSRLGIKLAESHNKGYRWQHEATIALACPTHAHAFELSAQEAEEWYRGRDIYPQTPPAADDVLVTFQHQPLGLAKRIGARIKNSYPRELVRDGKLFTGNS
What is the function of this protein?
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase F, 16S rRNA m5C1407 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmF.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLY1_ARATH
Sequence: MALNLRQKQTECVIRMLNLNQPLNPSGTANEEVYKILIYDRFCQNILSPLTHVKDLRKHGVTLFFLIDKDRQPVHDVPAVYFVQPTESNLQRIIADASRSLYDTFHLNFSSSIPRKFLEELASGTLKSGSVEKVSKVHDQYLEFVTLEDNLFSLAQQSTYVQMNDPSAGEKEINEIIERVASGLFCVLVTLGVVPVIRCPSGGPAEMVASLLDQKLRDHLLSKNNLFTEGGGFMSSFQRPLLCIFDRNFELSVGIQHDFRYRPLVHDVLGLKLNQLKVQGEKGPPKSFELDSSDPFWSANSTLEFPDVAVEIETQLNKYKRDVEEVNKKTGGGSGAEFDGTDLIGNIHTEHLMNTVKSLPELTERKKVIDKHTNIATALLGQIKERSIDAFTKKESDMMMRGGIDRTELMAALKGKGTKMDKLRFAIMYLISTETINQSEVEAVEAALNEAEADTSAFQYVKKIKSLNASFAATSANSASRSNIVDWAEKLYGQSISAVTAGVKNLLSSDQQLAVTRTVEALTEGKPNPEIDSYRFLDPRAPKSSSSGGSHVKGPFREAIVFMIGGGNYVEYGSLQELTQRQLTVKNVIYGATEILNGGELVEQLGLLGKKMGLGGPVASTSLSGGH
What is the function of this protein?
May be involved in the early secretory pathway.
What are the official names of this protein?
SEC1 family transport protein SLY1, AtSLY1.
What is the protein family that this protein belongs to?
Belongs to the STXBP/unc-18/SEC1 family.
Protein: DRE2_DROGR
Sequence: MEQFKDLQKSLYIWTDSGELDKRVQTIKEATGGEVAVENVHRLSFSSYANSSFDLIVIECAQLTDNYVKLLHMLKPSGKLHLIAYIGTPASLLQEIKLSGFINCGEDTAANTLTAEKPGYETGSAARLSFAKKAAGVNVWKISGDDEELIDEEDLLDEADKQKPDPSGLRVCSTTGKRKACKNCSCGLAEELESERTTSSANTENAKSSCGNCYLGDAFRCSTCPYLGMPAFKPGEKVQLANNLLKSDI
What is the function of this protein?
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.  Required for the maturation of extramitochondrial Fe-S proteins.  Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex.  Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase.  Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.
What are the official names of this protein?
Anamorsin homolog, Fe-S cluster assembly protein DRE2 homolog.
What is the protein family that this protein belongs to?
Belongs to the anamorsin family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion intermembrane space.
Protein: RNH2_STRCO
Sequence: MPYEPPTHTVERSLRATTGAKIIAGVDEVGRGAWAGPVTVCAAITGLRRPPVGLTDSKLLTIKRRTELEVELRTWVTSYALGHASPEEIDAMGMTAALRLAAVRALGTLPVRPDAVILDGKHDYLGAPWRVRTVIKGDQSCIAVAAASVLAKVQRDKMMAELGVDHADFGFADNAGYPSPVHKAALEERGPTPHHRLSWAYLDALPQWRHLKKVRSWVEGSVPEIEGQLGFDF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YNZE_BACSU
Sequence: MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIKLGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK
What are the official names of this protein?
Uncharacterized protein YnzE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YM8M_YEAST
Sequence: MFSIFKKKTSVQGTDSEIDEKITVKAKDKVVVSTEDEEVTTIVSSTKSTQVTNDSPWQDPTYFSSFGKELMFIATCMLAQLLNQAGQTHALCIMNVLSKSFNSEANNQAWLMASFPLAAGSFILISGRLGDIYGLKKMLIVGYVIVIVWSIISGLSKYSNSDAFFITSRAFQGVGIAFILPNIMGLVGHVYKVGSFRKNIVISFIGACAPTGGMFGGLFGGLIVTEDPNQWPWVFYAFGIATFLSLLMAWYSIPNNVPTNIHGLSMDWTGSALAIIGLILFNFVWNQAPIVGWDKPYIIVLLIISVIFLVAFFVYESKYAEVPLLPRAMTKNRHMIMILLAVFLGWGSFGIWTFYYVSFQLNLRHYSPVWTGGTYFVFVIFGSMAAFFVAFSIKRLGPALLLCFSLMAFDAGSIMFSVLPVEQSYWKLNFAMQAILCFGMDLSFPASSIILSDGLPMQYQGMAGSLVNTVINYSASLCLGMGGTVEHQINKSGNDLLKGYRAAVYLGVGLASLGVVISVTYMLENLWNRHRKSEDRSLEA
What are the official names of this protein?
Uncharacterized transporter YMR279C.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MURC_CLAM3
Sequence: MIAPDLTMDIPTELGRVHFVGIGGSGMSGIARLFLAAGHRVTGSDSRDSDAVQALRELGAEIHVGHDAAHVGDADALVVTGALWQDNPEYVLAKERGLPILHRSQALAWLISGQRLVAVAGAHGKTTSTGMIVTALLEAGRDPSFVNGGVIGGLGVSSAPGSEELFVVEADESDGSFLLYDTSVALITNVDADHLDHYGSHEAFDDAFVRFASAASELVVISSDDPGARRVTARIEGRVVTFGEDPAADIRITDIVTDGPVAFTLTHDGVSRRAALRVPGRHNAINAAGAYAVLVGLGVDPDDAIAGLAGFSGTGRRFELHAEVRGVSVYDDYAHHPTEVRAALEAARTVVGEGRIIAVHQPHLYSRTRMMAGDFARVYEELADHTIVLDVFGAREDPIPGVTGALVSECFEDAGHVDYLPDWQEAADRAAEIARDGDFIVTLSCGDVYRIIPQVIAALERPAGSPQPAASSRPRE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCM2_ORYSI
Sequence: MDDSENNAPSTPGSPGFSTDRLPPNTTTSRGATDPSSYSDDDDDDVVGAEEAEVDPNVLPEDDGVVAAEEEEDGEDLFNDNYLDDYRRMDEQDQYESVGLDDSIEDERNLDEIMADRRAAEAELDARDVRTGAAPDRKLPRMLHDQDTDEDMSFRRPKRHRANFRPPREPRTPRSDDDGDGATPSSPGRSQRGMYSGGDVPMTDQTDDDPYEDEFDEEDEMNMYRVQGTLREWVTRDEVRRFIAKKFKEFLLTYVNPKNEQGEFEYVRLINEMVLANKCSLEIDYKQFIYIHPNIAIWLADAPQSVIEVMEEVAKNVVFDLHKNYRNIHQKIYVRITNLPVYDQIRNIRQIHLNTMIRIGGVVTRRSGVFPQLQQVKYDCSKCGTVLGPFFQNSYTEVKVGSCPECQSKGPFTINVEQTIYRNYQKLTLQESPGIVPAGRLPRYKEVILLNDLIDCARPGEEIEVTGIYTNNFDLSLNTKNGFPVFATVVEANYVAKKQDLFSAYKLTDEDKAEIEKLAKDPRIGERIVKSIAPSIYGHEDIKTAIALAMFGGQEKNVKGKHRLRGDINVLLLGDPGTAKSQFLKYVEKTGHRAVYTTGKGASAVGLTAAVHKDPVTREWTLEGGALVLADRGICLIDEFDKMNDQDRVSIHEAMEQQSISISKAGIVTSLQARCSVIAAANPIGGRYDSSKTFTQNVELTDPIISRFDVLCVVKDIVDPFTDEMLARFVVDSHARSQPKGANLEDRVPTDVEDDPLAAARQADPDILSQDMLKKYITYAKLNVFPKIHDADLDKISHVYAELRRESSHGQGVPIAVRHIESIIRMSEAHARMHLRSYVSQEDVDMAIRVLLDSFISTQKFGVQKALQKNFRKYMTYKKDYNELLLLLLRTLVKDVLHFEEIVSGPTTRLTHIEVKVEDLKNKAQEYEIYDLRPFFSSAHFRDNNFVLDEGRGIIRHPLAA
What is the function of this protein?
Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
What are the official names of this protein?
DNA replication licensing factor MCM2, Minichromosome maintenance protein 2.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GATA_RICBR
Sequence: MTELNKLSVADSLKGLKNKEFTSKELVNAHIKQIEKHKNLNAYVTETFDLALKQAEEADQSYAKNHSRTLEGIPFAAKDLFCTKGIRTTACSNILREFIPNYESGVTQNIFNKGGVMLGKTNMDEFAMGSANITSCFGNVISPWKALDDGADLVPGGSSGGSAAAVSGFMATAALGSDTGGSVRQPASFTGLVGFKPTYGRCSRYGMVSFASSLDQAGIFTRSVLDSSIMLEAMIGFDERDSTSIKMEVPQLQPAIGSSIKGMKIGVPLSLGEGGIIEPDIMKMWHSTIELLKDAGAEIIDISLPHTKYGVAVYYVIAPAEASSNLSRYDGVRYGLRVEKENMSLDEMYEITRSSGFGDEVKRRIMIGTYVLSSSFMDAYYLKAQKVRRLVADDFNNAFAKVDAILLPSAPTEAFRIGEKQNDPTITYLNDLFTIPASLAGLPCVSVPAGLSNRGLPLGMQVIGKQLDEYNVLRVASAIEAGVKHIKFEPVGF
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RLMD_SHEB8
Sequence: MAQFFKAKPNSSKQLSAKLSLSVNQLDHLGAGIAQHQGKVVFIPGALPDETVTVQLTEQKKNYARAKLIKVDTPSSERVEPECPHYHTCGGCDLQHMSLSGQREHKEAALLDIMAKFAGAEGGTLSPALTGEGWHYRRRARLATLFDKNTKHLSLGFRAASSSNVVPISQCQVLAKPLSDLIVPFAKLLNQLSAKASLGHLELIAADNGHFAVLRITKALNDKDLAKLSAFAEQHLIHICLQDNEGQFQGVGAELVLPVYQLLGDKAESDAVSLSFTPGNFVQVNGQINKAMVAQALDWLAPAPDERILDLFCGMGNFSLPLAKMGADVIGVEGVAEMVTQARVNAKANNLDKLTFYHGDLSADLSLEPWMGKIDKLLLDPARAGAFESLQWLKKMKPRKVVYVSCNPASLARDSAVLLERGYRLQQLGLIDMFPQTHHIEAMALFELTK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: AGAK_SHESA
Sequence: MYYGLDIGGTKIELAIFDTQLALQDKWRLSTPGQDYSAFMATLAEQIEKADQQCGERGTVGIALPGVVKADGTVISSNVPCLNQRRVAHDLAQLLNRTVAIGNDCRCFALSEAVLGVGRGYSRVLGMILGTGTGGGLCIDGKLYLGANRLAGEFGHQGVSANVACRHQLPLYVCGCGLEGCAETYVSGTGLGRLYQDIAGQTADTFAWLNALRCNDPLAIKTFDTYMDILGSLMASLVLAMDPDIIVLGGGLSEVEEILAALPQATKAHLFDGVTLPQFKLADFGSASGVRGAALLGHGLDAGISYEA
What is the function of this protein?
Involved in the pathway of N-acetyl-D-galactosamine degradation.  Catalyzes the phosphorylation of N-acetyl-D-galactosamine (GalNAc) to yield D-galactosamine 6-phosphate (GalN-6-P).  It can also phosphorylate N-acetylglucosamine (GlcNAc).
What are the official names of this protein?
N-acetylgalactosamine kinase AgaK, GalNAc kinase, N-acetylglucosamine kinase, GlcNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSC_LACPL
Sequence: MVKSDNITWHQSQVSKAERQALNHHKSVVLWFTGLSGSGKSTIANAVEKALFDQQVGSYVLDGDNMRFGLNKNLGFSAEDREENIRRIGEVAKLFVDAGVITLTAFISPYRADRDKVRANLEVDEFIEVFVDTPLEVCEQRDVKQLYAKARRGEITGFTGIDAPYEAPIDPEITIDTSKQPLTASVQQVLNYLAEHHYVSLVTANEN
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: MYO1B_MOUSE
Sequence: MAKMEVKSSLLDNMIGVGDMVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLYKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFLDHEAEAVLEVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHSLIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLMRNLQTKNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQKRCKEAATTIAAYWHGTQARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP
What is the function of this protein?
Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.
What are the official names of this protein?
Unconventional myosin-Ib, MIH-L, Myosin I alpha, MMI-alpha, MMIa.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Protein: BL1S2_MOUSE
Sequence: MAAAAEGVPATRREEQPPRDDAAVETAEEAKEPAEADINELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAELQPYLDQINMIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR
What is the function of this protein?
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity).  In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:16760431, PubMed:21998198).  The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860).  As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery.  Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity).
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit 2, BLOC-1 subunit 2.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane. Note=Localizes to the centrosomes in a microtubule-dependent manner.
Protein: GPH_ECOLI
Sequence: MNKFEDIRGVAFDLDGTLVDSAPGLAAAVDMALYALELPVAGEERVITWIGNGADVLMERALTWARQERATQRKTMGKPPVDDDIPAEEQVRILRKLFDRYYGEVAEEGTFLFPHVADTLGALQAKGLPLGLVTNKPTPFVAPLLEALDIAKYFSVVIGGDDVQNKKPHPDPLLLVAERMGIAPQQMLFVGDSRNDIQAAKAAGCPSVGLTYGYNYGEAIDLSQPDVIYQSINDLLPALGLPHSENQESKND
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate (2P-Gly).  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: AP2M_ARATH
Sequence: MPVAASAIYFLNLRGDVLINRTYRDDVGGNMVDAFRTHIMQTKELGNCPVRQIGGCSFVYMRISNVYIVIVVSSNANVACGFKFVVEAVALFKSYFGGAFDEDAIRNNFVLIYELLDEIMDFGYPQNLSPEILKLYITQEGVRSPFSSKPKDKPVPNATLQVTGAVGWRREGLAYKKNEVFLDIVESVNLLMSSKGNVLRCDVTGKVLMKCFLSGMPDLKLGLNDKIGLEKESEMKSRPAKSGKTIELDDVTFHQCVNLTRFNSEKTVSFVPPDGEFELMKYRITEGVNLPFRVLPTIKELGRTRMEVNVKVKSVFGAKMFALGVVVKIPVPKQTAKTNFQVTTGRAKYNPSIDCLVWKIRKFPGQTESTLSAEIELISTMGEKKSWTRPPIQMEFQVPMFTASGLRVRFLKVWEKSGYNTVEWVRYITKAGSYEIRC
What is the function of this protein?
Subunit of the adaptor protein complex 2 (AP-2).  Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways.  Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation.  AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome.  AP-2 recognizes Y-X-X-Phi endocytosis signal motif within the cytosolic tails of transmembrane cargo molecules.  The complex binds polyphosphoinositides.
What are the official names of this protein?
AP-2 complex subunit mu, Adaptor protein complex AP-2 subunit mu, Adaptor protein-2 mu-adaptin, Adaptor-related protein complex 2 subunit mu, At-muA-Ad, Clathrin assembly protein complex 2 mu medium chain, Mu2-adaptin, Protein AP47/50, AtAP47/50.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans- Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane (By similarity). Detected in the trans-Golgi membrane but not in the plasmamembrane (PubMed:14871308).
Protein: STPAP_RAT
Sequence: MAAVDSDVVSLPRGRFRCCLCDVTTANRPSLDAHLKGRKHRDLVQLRATRKAQGLRSVFVSGFPRDVGSAQLSEYFQTFGPVANIVMDKDKGVFAIVEMGDISAREAVLSQPKHSLGGHTLRVRPREQKEFQSPASKSPKGVDSNSHQLAQALAEAADVGAQMVKLVELRELSEAERQLRTLVVALMQEVFTEFFPGCVVHPFGSSVNSFDVHGCDLDLFLDLGDMEEPQPDPQTPKLPEASSLDSTLASSLDPQVLACTPASLDSLSPTSLQDSEALDFETPSSLAPQTPDSALGSDTVTSPQSLPPVSPLEEDRGEGKHRKELELAEASKDEKEEATAVLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDISLSNRLALYNSRFLNLCSEMDSRVRPLVYTLRCWAQHNGLSGGGPLLNNYALTLLVIYFLQTRDPPVLPTVAQLTQRSGEGEQVEVDGWDCSFPKDASRLEPSTNVEPLSSLLAQFFSCVSCWDLSGSLLSLREGQALMVAGGLPSDLWEGLRLGPMNLQDPFDLSHNVAANVTSRVAKRLQSSCGAAASYCRSLQYQQRSSRGRDWGLLPLLQPSSPSSLLSAKLIPLPSAPFPQIITALVSVLREALGCHIEQGTKRRRSEGARSKDSPLGGANKRPRLSGQEKSCEEGKEEPQGCAGDHSENEVEEMVIELRETPQDWALLHCGPPGELPLMTAKCLDKTAEQNPMEPEGAGEGSPGETEKEASHPSSVSWRCALWHQIWQGRRRARRRFQQQTKEEGRGGPSTGAEWLAVEARVTQELKGPKSEQQRLQGEPLLTFVASASQAEQTLTVAPLQDPQGLFPGLHHFLQVFIPQALKNLLK
What is the function of this protein?
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs.  Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1.  In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs.  In addition to adenylyltransferase activity, also has uridylyltransferase activity.  However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase.  Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA.  Not involved in replication-dependent histone mRNA degradation.
What are the official names of this protein?
Speckle targeted PIP5K1A-regulated poly(A) polymerase, Star-PAP, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus speckle.
Protein: XDH_ORYSJ
Sequence: MGSLTRAEEEETAAAEEWSGEAVVYVNGVRRVLPDGLAHLTLLQYLRDIGLPGTKLGCGEGGCGACTVMVSCYDQTTKKTQHFAINACLAPLYSVEGMHIITVEGIGNRQRGLHPIQERLAMAHGSQCGFCTPGFVMSMYALLRSSEQPPTEEQIEDSLAGNLCRCTGYRPIIDAFRVFSKRDDLLYNNSSLKNADGRPICPSTGKPCSCGDQKDINGSESSLLTPTKSYSPCSYNEIDGNAYSEKELIFPPELQLRKVTSLKLNGFNGIRWYRPLKLKQVLHLKACYPNAKLIIGNSEVGVETKFKNAQYKVLISVTHVPELHTLKVKEDGIHIGSSVRLAQLQNFLRKVILERDSHEISSCEAILRQLKWFAGTQIRNVASVGGNICTASPISDLNPLWMATGATFEIIDVNNNIRTIPAKDFFLGYRKVDLKPDEILLSVILPWTRPFEFVKEFKQAHRREDDIALVNAGMRVYIRKVEGDWIISDVSIIYGGVAAVSHRASKTETFLTGKKWDYGLLDKTFDLLKEDVVLAENAPGGMVEFRSSLTLSFFFKFFLHVTHEMNIKGFWKDGLHATNLSAIQSFTRPVGVGTQCYELVRQGTAVGQPVVHTSAMLQVTGEAEYTDDTPTPPNTLHAALVLSTKAHARILSIDASLAKSSPGFAGLFLSKDVPGANHTGPVIHDEEVFASDVVTCVGQIVGLVVADTRDNAKAAANKVNIEYSELPAILSIEEAVKAGSFHPNSKRCLVKGNVEQCFLSGACDRIIEGKVQVGGQEHFYMEPQSTLVWPVDSGNEIHMISSTQAPQKHQKYVANVLGLPQSRVVCKTKRIGGGFGGKETRSAIFAAAASVAAYCLRQPVKLVLDRDIDMMTTGQRHSFLGKYKVGFTDDGKILALDLDVYNNGGHSHDLSLPVLERAMFHSDNVYDIPNVRVNGQVCFTNFPSNTAFRGFGGPQAMLIAENWIQHMATELKRSPEEIKELNFQSEGSVLHYGQLLQNCTIHSVWDELKVSCNFMEARKAVIDFNNNNRWRKRGIAMVPTKFGISFTTKFMNQAGALVQVYTDGTVLVTHGGVEMGQGLHTKVAQVAASSFNIPLSSIFISETSTDKVPNATPTAASASSDLYGAAVLDACQQIMARMEPVASRGNHKSFAELVLACYLERIDLSAHGFYITPDVGFDWVSGKGTPFYYFTYGAAFAEVEIDTLTGDFHTRTVDIVMDLGCSINPAIDIGQIEGGFIQGLGWAALEELKWGDDNHKWIRPGHLFTCGPGSYKIPSVNDIPLNFKVSLLKGVLNPKVIHSSKAVGEPPFFLGSAVLFAIKDAISAARAEEGHFDWFPLDSPATPERIRMACVDSITKKFASVYYRPKLSV
What is the function of this protein?
Key enzyme involved in purine catabolism.  Catalyzes the oxidation of hypoxanthine to xanthine and the oxidation of xanthine to urate.
What are the official names of this protein?
Xanthine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.