PharMolix/UniProtQA huggingface dataset:
Protein: YCF3_OSTTA
Sequence: MPRSQKNDNFIDKTFTVVADILLKVLPTTRNEKEAFVYYRDGMSAQAEGEYAEALQNYAQAMRLEVDPYDRSFIFYNIGLIHTSNGEHTKALEYYYQALDRNPSLPQALNNIAVIYHYRGEQALAAGNIPDSETLFEKAAEYWKEAIRLAPLNYSEAQNWLQTTGR
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RL17_STAEQ
Sequence: MGYRKLGRTSDQRKAMLRDLATSLIVSERIETTEARAKEVRSVVEKLITLGKKGDLASRRNAAKTLRNVEILNEDDSTQTALQKLFGEIAERYSERQGGYTRILKVGPRRGDGAESVIIELV
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PHL_LEPIR
Sequence: MRIKKYTKVRLLVNCCLLLFFLIDCGADRQSLYKDLLASLIYISDNKNIGSTNSDLTGSGSVSSSPADAAPENSILANSIPENMGIKILTHNVFLLPKTLPGWGNWGQNERAQRIVSSNYIQNQDVIVFDEAFDTDARKILLDGVRSEYPYQTDVIGRTKKGWDATLGLYRTDAFTNGGVVIVSKWPIEEKIQHVFKEKGCGADVFSNKGFAYVRIDKNGRKFHIIGTHVQAQDSGCANLGVVSRVNQFNEIRDFIDSKKIPKNEMVLIAGDLNVIKGSREYHQMLCILNVNNPKYVGVPFTWDTKTNEIAAFYYKKVEPAYLDYIFVSKSHFQPPIWQNLAYDPISAKTWTAKGYTSDEFSDHYPVYGFIYADSSTPTKSGRKRKYDRVSFVSVATGKKIQANSEKSNAWLKVNATTETDLTKFNLVQTNDPDSNPSCMKSGHVRIESSHSLNYFWNWWLGGGKGNYAYYPKFNDGSNRIQIINLDGGCLQDGSRVAFKDYDTISRRQYFLTVWEGGNWDKYLYLWRSHIGLREIFYLKLDSSPEMNWSKKLIYR
What are the official names of this protein?
Sphingomyelinase C, Sphingomyelin phosphodiesterase, SMase.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3100_BACCN
Sequence: MDGFDKTMKFSIQDEKQSVHVNDVLLTVYDALQEKGYNPINQIVGYLLSGDPAYIPRHKDARNIIRKLERDELIEELVKSYLKQHREE
What are the official names of this protein?
UPF0297 protein Bcer98_3100.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: NU2C2_SOLTU
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFDGSLIFPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVLSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVLIGLLTSVVSIYYYLKIIKLLMTGRNQEITPHVRNYRRSPLRSNNSIELSMIVCVIASTIPGISMNPIIAIAQDSLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 B, chloroplastic, NAD(P)H dehydrogenase, subunit 2 B, NADH-plastoquinone oxidoreductase subunit 2 B.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CHLF_CHLFP
Sequence: MKLESDHVIATSDSSDYTSEPTANKLSKRRKKVNYWEKFCSWVTSTENRLYVGWFGVLMIPCVLTAATVFIIAIIAAPPVDMDGIGVPISGSILSGNNIITAAVVPTSAAIGLHFYPIWEAASIDEWLYNGGPYQLIVLHFLIGIIAYQDREWELSYRLGMRPWISLAFTAPVAASVSVLLIYPVGQGSLSAGMPLGISGTFHFMLQFQADHNILMSPLHQLGVIGVLGGAFAAAMHGSLVTSTLIRSHNHSESESINKGYKLGQQHPTYNFRSAQVYLWHLIWQRVSFPNSRKLHFFLAALPVAGIWSAALGVDIAAFDFDYLQFHQPELKSQGQIIHTWADTIDWASLGIKVLDERHIYDFPENLTAGEVVPWK
What is the function of this protein?
Synthesizes chlorophyll f or chlorophyllide f (Chl f, 2-formyl chlorophyll a), probably by oxidation of chlorophyll a or chlorophyllide a and reduction of plastoquinone.  The reaction is probably light-dependent (PubMed:27386923).  Chl f absorbs far red light (FRL, 707 nm in 100% methanol), and is synthesized when cells are grown in FRL, where it provides the advantage of extending the spectral range of harvested light in terrestrial cyanobacteria (PubMed:27386923).  When ectopically expressed in Synechococcus PCC 7002 (which does not grow in FRL and does not make Chl f) produces Chl f (0. 059% of total chlorophyll) (PubMed:27386923).
What are the official names of this protein?
Light-dependent chlorophyll f synthase, Chl f synthase, Super-rogue PsbA4, Sr-PsbA4.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi- pass membrane protein.
Protein: 6PGL3_ORYSI
Sequence: MSASAAVSSTCAAASSTTSRRSSSSPASRVQATPRRSLPSRLVASRTSPRSPVVPPVYATASPGGAGGTTAAAARKKLLIFDAEEYLAESLAKYTARLSGEAVAERGAFTVALSGGSLIKALRKLTESPYLEAVEWSKWHVFWVDERVVPKDHADSNYKLAMDGLLSKVPIPASQIYAINDTLSAEGAADEYETCLKQLVNDGVVAISEVTGFPKLDLMLLGMGPDGHVASLFPGHPVVNENLKWVSYIKDSPKPPPERITFTFPLVNSSAHIALVVTGAGKAGAVHKAFSDKQSSSDLLPVEMVSQQEGVLTWFTDKPAVSMLSSI
What is the function of this protein?
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
Probable 6-phosphogluconolactonase 3, chloroplastic, 6PGL 3.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MD15A_ARATH
Sequence: MDNNNWRPSLPNGEPAMDTGDWRTQLPPDSRQKIVNKIMETLKKHLPFSGPEGINELRRIAARFEEKIFSGALNQTDYLRKISMKMLTMETKSQNAAGSSAAIPAANNGTSIDSIPTNQGQLLPGSLSTNQSQAPQPLLSQTMQNNTASGMTGSTALPSSMPPVSSITNNNTTSVVNQNANMQNVAGMLQDSSGQHGLSSNMFSGPQRQMLGRPHAMSSQQQQQPYLYQQQLQQQLLKQNFQSGNVPNPNSLLPSHIQQQQQNVLQPNQLHSSQQPGVPTSATQPSTVNSAPLQGLHTNQQSSPQLSSQQTTQSMLRQHQSSMLRQHPQSQQASGIHQQQSSLPQQSISPLQQQPTQLMRQQAANSSGIQQKQMMGQHVVGDMQQQHQQRLLNQQNNVMNIQQQQSQQQPLQQPQQQQKQQPPAQQQLMSQQNSLQATHQNPLGTQSNVAGLQQPQQQMLNSQVGNSSLQNNQHSVHMLSQPTVGLQRTHQAGHGLYSSQGQQSQNQPSQQQMMPQLQSHHQQLGLQQQPNLLQQDVQQRLQASGQVTGSLLPPQNVVDQQRQLYQSQRTLPEMPSSSLDSTAQTESANGGDWQEEVYQKIKSMKETYLPDLNEIYQRVAAKLQQDSMPQQQRSDQLEKLRQFKTMLERMIQFLSVSKSNIMPALKDKVAYYEKQIIGFLNMHRPRKPVQQGQLPQSQMQPMQQPQSQTVQDQSHDNQTNPQMQSMSMQGAGPRAQQSSMTNMQSNVLSSRPGVSAPQQNIPSSIPASSLESGQGNTLNNGQQVAMGSMQQNTSQLVNNSSASAQSGLSTLQSNVNQPQLSSSLLQHQHLKQQQDQQMQLKQQFQQRQMQQQQLQARQQQQQQQLQARQQAAQLQQMNDMNDLTSRQGMNVSRGMFQQHSMQGQRANYPLQQLKPGAVSSPQLLQGASPQMSQHLSPQVDQKNTVNKMGTPLQPANSPFVVPSPSSTPLAPSPMQVDSEKPGSSSLSMGNIARQQATGMQGVVQSLAIGTPGISASPLLQEFTSPDGNILNSSTITSGKPSATELPIERLIRAVKSISPQALSSAVSDIGSVVSMVDRIAGSAPGNGSRASVGEDLVAMTKCRLQARNFMTQEGMMATKKMKRHTTAMPLSVASLGGSVGDNYKQFAGSETSDLESTATSDGKKARTETEHALLEEIKEINQRLIDTVVEISDDEDAADPSEVAISSIGCEGTTVRFSFIAVSLSPALKAHLSSTQMSPIQPLRLLVPCSYPNGSPSLLDKLPVETSKENEDLSSKAMARFNILLRSLSQPMSLKDIAKTWDACARAVICEYAQQFGGGTFSSKYGTWEKYVAAS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 15a.
What is the protein family that this protein belongs to?
Belongs to the plant Mediator complex subunit 15 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CELA1_MOUSE
Sequence: MLRFLVFASLVLCGHSTEDVPETDARVVGGAEARRNSWPSQISLQYQYGGSWHHTCGGTLIRSNWVMTAAHCVDSPMTYRVVVGEHNLSQNDGTEQYVNVQKIVSHPYWNKNNVVAGYDIALLRLAKSVTLNNYVQLGVLPREGTILANNSPCYITGWGRTRTNGELAQTLQQAYLPSVSYSICSSSSYWGSSVKNTMVCAGGDGVRSGCQGDSGGPLHCMVNGQYAVHGVTSFVSSMGCNVARKPTVFTRVSAYISWMNNVIASN
What is the function of this protein?
Acts upon elastin.
What are the official names of this protein?
Chymotrypsin-like elastase family member 1, Elastase-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Elastase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPD_PECCP
Sequence: MQLSSTKPSSKTREPSTAQDIVTMQNILEKLYRAESISRQESQALFGAIIRGELEASQLAAALISMKVRGEHPDEIAGAATALLADAQPFPRPDYLFADIVGTGGDGTNSINISTASAFVAASCGLKIAKHGNRSVSSRSGSSDLLSAFGIKLDMSAQDSRQALDDLGVCFLFAPQYHLGFRHAMPVRQQLKTRTVFNVLGPLVNPARPPLALIGVYSPELVRPIAETLKVLGYQRAAVVHGGGMDEVAIHAPTQVAELNNGEIETYELTHRDFGLDTYSLSALQGGTPEENRDILASLLQGKGERAHAAAVAANVALLLRLFGQENLRQNAQQALEVIHSGQAYQRVIALSARG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: ZAPA_ECO27
Sequence: MSAQPVDIQIFGRSLRVNCPPDQRDALNQAADDLNQRLQDLKERTRVTNTEQLVFIAALNISYELAQEKAKTRDYAASMEQRIRMLQQTIEQALLEQGRITEKTNQNFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: ACADS_MOUSE
Sequence: MAAALLARARGPLRRALGVRDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDREHLFPTAQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRACASTGVIMSVNNSLYLGPILKFGSAQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRNAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
What is the function of this protein?
Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats.  The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA.  Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.
What are the official names of this protein?
Short-chain specific acyl-CoA dehydrogenase, mitochondrial, SCAD, Butyryl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RPOB_ANGEV
Sequence: MILKENKKMFVLPEFGRIQFEGFQRFIHQDLVEELTNFPKIEDIDQEVEFRLFGERYRLTEPCIKERDAVYQSFTYSSDLYVPAQLMRRRNGRIQRQTVHFGSIPLMNSQGTFVINGIARVVINQILRSPGIYYDSELDHNGNSIYTGTIISDWGGRFKSEIDGKKRIWVRLSKNRKVSIIILLLAMGLNMNDILKNVRYPNIFLRLFQRQAENIQSYEDAIVELYKNLYSAGGNLVFSDSICKELQTKFFQQKFELGQFGRRNLNKKLNLDVPGNEHLLLPQDLLAAVDYLIGVNYGIGTLDDIDDLKNRRVRSVADLLREQLGLALDRLEILIRQTIHTVARRKRLVTPKGLITSAPLTTIFQDFFGSHSLSQFLDQTNPLAELTHKRRLSSLGPGGLTRRTASFQVRDINPSHYGRICPIETSEGMNAGLIASLAIHAKVNDRGSLLSPFYKISKTLGEEHIVYLSSEEDEYYRIATGNTLSLDREIREERATPARYRQEFLTIAWKQIHFRSIFPFQYFSIGTSLIPFLEHNDANRALMGSNMQRQAVPLSQPEKCIVGTGLESQIALDSGSVVVSNQDGQIAYLDGETISILLQNEKTVDIKSIIYERSNNNTCIHQRPVVSQGERLRKGQLLADGTATVGGELALGRNILVAYMPWEGYNFEDAVLISERLIYEDIYTSFHIERYEINIYTTSQGPEKITKEIPHLDSYVLRHLDNNGLVVPGSWVETGDVLVGKLTPQEAENSLRVPEGKLLQAISGIQLANTRESCLKVPIGGRGRVIDVRWIYDEDTLPNIANMVHVYILQKRKIQVGDKVAGRHGNKGIVSKILPRQDMPYLQDGTPVDMILSPLGVPSRMNVGQIFECLLGLAGDILKKHYRITPFDERYEREASRKLVFSELHEASQEAAIPWLFEPDHPGKSRLIDGRTGDIFEQPVTIGKAYMMKLIHQVDDKIHARSSGPYALVTQQPLRGRSRGGGQRVGEMEVWALEGFGVSYILQEMLTIKSDHIPARSKLLGSIVTGKSIPKPNTVPESFRLLVRELRSLAVNSDHNLIFEKDLRKKVKDV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PG079_VAR67
Sequence: MSKVIKKRVETSPRPTASSDSLQTCAGVIEYAKSISKSNAKCIEYVTLNASQYANCSSISIKLTDSLSSQMTSTFIMLEGETKLYKNKSKQDRSDGYFLKIKVTAASPMLYQLLEAVYGNIKHKERIPNSLHSLLVETITEKTFKDESIFINKLNGAMVEYVSTGELSILRSIEGELESLSKRERQLAKAIITPVVFYRSGTETKITFALKKLIIDREVVANVIGLSGDSERVSMTENVEEDLARNLGLVDIDDEYDEDSDKEKPIFNV
What is the function of this protein?
Plays an essential role in viral DNA replication.  Binds to ssDNA with high affinity and localizes to cytoplasmic factories where nascent viral genomes accumulate.  May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation.
What are the official names of this protein?
Protein OPG079, Protein I3.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG079 family.
Protein: NUOA_SHIDS
Sequence: MSMSTSTEVIAHHWAFAIFLIVAIGLCCLMLVGGWFLGGRARARSKNVPFESGIDSVGSARLRLSAKFYLVAMFFVIFDVEALYLFAWSTSIRESGWVGFVEAAIFIFVLLAGLVYLVRIGALDWTPARSRRERMNPETNSIANRQR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CELF4_DANRE
Sequence: MATLTNGQVDAAVHGGAASTNGLVNGISHTHSPASCATIPMKDHDAIKLFIGQIPRNLDEKDLRPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCARESALKAQTALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLNKQQCEDDVRRLFESFGSIEECTILRGPDGNSKGCAFVKYSTHAEAQAAISALHGSQTMPGASSSLVVKFADTDKERTIRRMQQMAGQMGIFNPMALQFGAYGAYAQVQQQAALMASVGQGGYLSPMAAFAAAQMQHMATINGLPGAPMTPTSGGSTPPGITAPTVTSIPSPISVNGFTGLPPPQANGQAPAEAMFTNGIHPYPVLQEVVFREDSEKGGLGVAQRSCFGVQGSCFLSSLSEAQSPTAADPLQQAYAGVQQYAAFPAAYGQISQAFPQPPPIIPQQQREGPEGCNLFIYHLPQEFGDGELMQMFLPFGNVISSKVFVDRATNQSKCFGFVSFDNPGSAQAAIQSMNGFQIGMKRLKVQLKRPKDANRPY
What is the function of this protein?
RNA-binding protein that may be implicated in the regulation of pre-mRNA alternative splicing.
What are the official names of this protein?
CUGBP Elav-like family member 4, CELF-4, Bruno-like protein 4, CUG-BP- and ETR-3-like factor 4, RNA-binding protein BRUNOL-4.
What is the protein family that this protein belongs to?
Belongs to the CELF/BRUNOL family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: TBC23_HUMAN
Sequence: MAEGEDVPPLPTSSGDGWEKDLEEALEAGGCDLETLRNIIQGRPLPADLRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLQFIDQLSVPEEKAAELLLDIESVITFYCKSRNIKYSTSLSWIHLLKPLVHLQLPRSDLYNCFYAIMNKYIPRDCSQKGRPFHLFRLLIQYHEPELCSYLDTKKITPDSYALNWLGSLFACYCSTEVTQAIWDGYLQQADPFFIYFLMLIILVNAKEVILTQESDSKEEVIKFLENTPSSLNIEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDDADLSQALCLAISVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLSTAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVDGPENGYGHWIASTSGSRSSINSVDGESPNGSSDRGMKSLVNKMTVALKTKSVNVREKVISFIENTSTPVDRMSFNLPWPDRSCTERHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDVKHHFPCKEVKESGHMFPSHLLVTATHMYCLREIVSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATKAIKQQIMKVLDALES
What is the function of this protein?
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking (PubMed:28823707).  Involved in endosome-to-Golgi trafficking.  Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197, PubMed:29426865).  Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865).  Plays a role in brain development, including in cortical neuron positioning (By similarity).  May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity).  May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways.  Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (By similarity).
What are the official names of this protein?
TBC1 domain family member 23, HCV non-structural protein 4A-transactivated protein 1.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Note=Localization to the trans-Golgi is regulated by ARL1 and ARL5B/ARL8. ARL1 increases Golgi localization, while ARL5B decreases it. Recruitment to the trans-Golgi network requires the presence of GOLGA1 and GOLGA4, but not that of FAM91A1 (PubMed:29084197, PubMed:28823706). Recruited on AP-1-derived vesicles by WDR11 complex (PubMed:29426865).
Protein: S2534_DANRE
Sequence: MNSAFSGPSSPTPGPSPPRPPLWPPLDFGLGALACCGACVFTNPLEVVKTRLQLQGELRARGSYRRLYRGVLQALWVVGRTDGLRGLQKGLTAALLYQGLMNGLRLGSYAQMQAAGVTDGPCCSLIAGAAAGALGAFIASPAYLVKTHLQAQTVAAIAVGHQHNHQGMSSALVSIYRREGVCGLWRGVNGAVPRVMVGSATQLATFSSAKDWITHTQWFSPLSSLNTLCAAVMSGVAVSIIMTPFDVISTRLYNQPVDQFKQGRLYCGFVDCLLKVCAAEGVLGLYKGMTPVFVRLAPHTTLSMLLWDVLRQRALPYTH
What are the official names of this protein?
Solute carrier family 25 member 34.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS9_STRPI
Sequence: MSQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVINQPFAVTSTVGSYDVFVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAGLLTRDSRKVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: LEUD_POLNS
Sequence: MEKFTVYKGLVAPLNRENVDTDAIIPKQFLKSIKKTGFGQNLFDEWRYLDHGEPGQDCSTRPINPDFVLNQPRYKGAGILLARKNFGCGSSREHAPWALDQFGFRAVIAPSFADIFYSNCFKNGVLPIVLTEVQVDHLFNETQAFNGYQLTIDLEAQQVIAPDGTAYNFDVAPFRKYCLLNGLDDIGLTLQHADKIKAYEAERILKMSWLATQLP
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: NDRG1_HUMAN
Sequence: MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSAGPKSMEVSC
What is the function of this protein?
Stress-responsive protein involved in hormone responses, cell growth, and differentiation.  Acts as a tumor suppressor in many cell types.  Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis.  Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath.  Required for vesicular recycling of CDH1 and TF.  May also function in lipid trafficking.  Protects cells from spindle disruption damage.  Functions in p53/TP53-dependent mitotic spindle checkpoint.  Regulates microtubule dynamics and maintains euploidy.
What are the official names of this protein?
Protein NDRG1, Differentiation-related gene 1 protein, DRG-1, N-myc downstream-regulated gene 1 protein, Nickel-specific induction protein Cap43, Reducing agents and tunicamycin-responsive protein, RTP, Rit42.
What is the protein family that this protein belongs to?
Belongs to the NDRG family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53- dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.
Protein: GLYA_AMOA5
Sequence: MLRDTQIFTLIEKEYQRQNEGLELIASENFVSQQIMEAAGSILTNKYAEGLPGRRYYGGCEIVDEIETLAIERAKSLFHASWANVQPHSGSQANAAVMFAVLEPGDKILGFNLAHGGHLTHGSPVNFSGQLYESHFYGVQPETGLIDWEEVGTIAEQVNPKLIICGASAYSRDWDYKRLRAIADQVGALLLADISHPAGLISRGLLNDPVPYCHFITTTTHKTLRGPRGGMILMGADFENPFGKKTTKGKLKSMSTLLDASVFPGIQGGPLEHIIAAKAIAFQEAMSDDYFNYILQVQKNTRQLAQSFVKRGYNIVSGGTDNHLILIDLRNKGITGKLAEEALIKASITLNKNMVPFDDQSPLITSGIRIGTPAVTTRGMQETDMEQIAAWIDDVLKNHENESKIDSIRKEIGNYMLQFPLP
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.