PharMolix/UniProtQA huggingface dataset:
Protein: C26AA_BACTF
Sequence: MNSEEMNHVNPFEISDNNDVSIPSQRYPFANDPADSVFCADDFLQSYGEFNMDNFGESEPFIDASGAINAAIGVTGTVLGFLGVPFAGALTTFYQKLFGFLFPNNNTKQWEEFMKQVEALIDEKISDAVRNKAISELQGLVNNITLYTEALEEWLENKENPAVRDRVLQRWRILDGFFEQQMPSFAVKGFEVLLLVVYTQAANLHLLSLRDAYIYGAEWGLTPTNIDQNHTRLLRHSAEYTDHCVNWYNTGLKQLENSDAKSWFQYNRFRREMTLSVLDVIALFPAYDVKMYPIPTNFQLTREVYTDVIGKIGRNDSDHWYSANAPSFSNLESTLIRTPHVVDYIKKLKIFYATVDYYGIYGRSGKWVGHIITSATSANTTETRNYGTIVNHDSVELNFEGKNIYKTGSLPQGVPPYQIGYVTPIYFITRAVNFFTVSGSKTSVEKYYSKKDRYYSEGLPEEQGVFSTEQLPPNSIAEPEHIAYSHRLCHVTFISVSNGNKYSKDLPLFSWTHSSVDFDNYVYPTKITQLPATKGYNVSIVKEPGFIGGDIGKNNGQILGKYKVNVEDVSQKYRFRVRYATETEGELGIKIDGRTVNLYQYKKTKAPGDPLTYKAFDYLSFSTPVKFNNASSTIELFLQNKTSGTFYLAGIEIIPVKSNYEEELTLEEAKKAVSSLFTDARNALKIDVTDYQIDQAANLVECISGDLYAKEKIVLLRAVKFAKQLSQSQNLLSDPEFNNVNRENSWTASTSVAIIEGDPLYKGRAVQLSSARDENFPTYLYQKIDESTLKPYTRYQLRGFVEGSENLDVYLIRYGAAHVRMNVPYNLEIIDTSSPVNPCEEVDGLSHRSCNVFDRCKQSISVAPDANTGPDQIDGDPHAFSFHIDTGTVDSTENLGIWVAFKISELDGSAIFGNLELIEVGPLSGEALAQVQRKEEKWKQVLAKKRETTAQTVCSGEASQLTNSSQILKIRNYDLIQNFRIFSLRNTLSIKFKIYTITNYPYSRLNYDLFMELENRIQNASLYMTSNILQNGGFKSDVTSWETTANAEVQQIDGASVLVLSNWNASVAQSVNVQNDHGYVLRVTAKKEGIGNGYVTILDCANHIDTLTFSACRSDSDTSSNELTAYVTKTLEIFPDTEQIRIEIGETEGMFYVESVELIRMEN
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of insects.
What are the official names of this protein?
Pesticidal crystal protein Cry26Aa, 131 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryXXVIA(a).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: NOP2_YEAST
Sequence: MGSRRHKNKQAAPPTLEEFQARKEKKANRKLEKGKRPSTTQGDEVSDRKKKKSKPFKKSRKEEEEVVEEDKDLPEVDLEELSKARKSLFDDEEDDDEAGLVDEELKDEFDLEQEYDYDEDEDNDAHPIFSDDDDEADLEELNAQNMEALSKKLDEEEAEEAEEAEMELVEAENMQPRADILPTEEQEEMMAQETPNLTSTRTRMIEIVKVLENFKTLGAEGRSRGEYVDRLLKDICEYFGYTPFLAEKLFNLFSPAEAMEFFEANEIARPITIRTNTLKTRRRDLAQTLVNRGVNLQPIGSWTKVGLQIFDSQVPIGATPEYLAGHYILQAASSFLPVIALDPHENERILDMAAAPGGKTTYISAMMKNTGCVFANDANKSRTKSLIANIHRLGCTNTIVCNYDAREFPKVIGGFDRILLDAPCSGTGVIGKDQSVKVSRTEKDFIQIPHLQKQLLLSAIDSVDCNSKHGGVIVYSTCSVAVEEDEAVIDYALRKRPNVKLVDTGLAIGKEAFTSYRGKKFHPSVKLARRYYPHTYNVDGFFVAKFQKIGPSSFDDNQASAKEKETAARKEALEEGIIHSDFATFEDEEDDKYIEKSVKNNLLKKGVNPKAKRPSNEK
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.  Required for 60S ribosomal subunit synthesis and processing.
What are the official names of this protein?
25S rRNA (cytosine(2870)-C(5))-methyltransferase, Nucleolar protein 2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TRPF_LEGPA
Sequence: MNPSRIRIKMCGMTRSEDIQYAIDLGVDAIGLIFYPKSARNVSLEKARIIVNNIPPFVDIVAVLVNPEQSFVQLIINEIPVQLLQFHGEESSEFCRQFNKPFIKAIHPKTAIQIQSAVDEFFDASAILLDTPSDKERGGTGLTFDWNIIPENLSKPYILAGGLNESNILEAITMCHPYAVDVCSGIEASPGVKDHLKMSRFIKAIWG
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: CYB_ANISC
Sequence: MITNLLLKSAGLLPVTTNISTWWNFGSMLMVCLAIQIATGFFLAMHYTANITLAFSSIVHIVRDVPYGWLMQNLHAIGASMFFACIYIHVARGLYYGSYMYKKTWSSGIMILLTLMATAFFGYVLPWGQMSFLAATVITNLLTTIPYLGTFLTTWLSGGFAINDPTLTRFFALHLILPSMVTALSSIHIMLLHETGSSNPLGTNPNIDKTQFHPYHTYKDLLMLSILILILLSITSFIPDILNDPENFSKANPLVTPQHIKPEWYFLFAYSISRSIPNKLGGAFALAMSIMILFSLPLTHTSNLRTMTFRPTAQYLFWTLITTFLLLTWTATKPVEIPFTTVSQGASLMYFSFFIMLPLPGLMENKTSKPN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL5_DICNV
Sequence: MARLQKFYKEEVIKKLQSELGLKNVMEVPRLEKITINMGVGEAVNDKKIMDNAVRDLALISGQKPVVTKSKKSIAGFKIRDGWAIGCKVTLRRQQMYEFLDRLINVSLPRTRDFRGLNPKSFDGRGNYTFGVKEHIIFPEIDFEKTDAIRGMDITFTTSAKDNAQAKALLEAFGFPFRG
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RS142_ARATH
Sequence: MSKRKTKEPKVETVTLGPSVREGEQVFGVVHIFASFNDTFIHVTDLSGRETLVRITGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITAMHVKLRATGGNKTKTPGPGAQSALRALARSGMKIGRIEDVTPIPTDSTRRKGGRRGRRL
What are the official names of this protein?
40S ribosomal protein S14-2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FKBP4_HUMAN
Sequence: MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
What is the function of this protein?
Immunophilin protein with PPIase and co-chaperone activities.  Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90).  May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments.  The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening.  Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.  May have a protective role against oxidative stress in mitochondria.
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 51 kDa FK506-binding protein, FKBP51, 52 kDa FK506-binding protein, 52 kDa FKBP, FKBP-52, 59 kDa immunophilin, p59, FK506-binding protein 4, FKBP-4, FKBP59, HSP-binding immunophilin, HBI, Immunophilin FKBP52, Rotamase.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).
Protein: YR306_MIMIV
Sequence: MPRKITSYKTSLQGLREENEDVELMNLNLLLTGKPNNPKYAPIDLFIVCDGHGGKEVAEYVAPRLNRYIMNNNNTFPLHRQHVAKIYDAIQNELIGKGIARTWWMYCSSYY
What are the official names of this protein?
Uncharacterized protein R306.
Protein: RR18_EMIHU
Sequence: MYKNPIKANLGEEVNNSLNYKDVSILSNFVNEQGKILPRRLTGLKSKQQKKVTKLIKQARIAALLPFVIGKN
What are the official names of this protein?
30S ribosomal protein S18, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRPA_ACTP2
Sequence: MSRFDTLFANLKAKNEGAFVPFVTLCDPDFDCSFEIIETLIANGADALELGFPFSDPLLDGPVIQAANKRALDGGYSTDACFEMIAKIRSKYPEIPIGLLLCANLVFVPTQDVFFKRCAETGVDAVLIADVPVLAAEEFTQAAKKHGIQSVFICPPNADQATIERIARLTEGYTYLVSRAGVTSAENQAHAKNLDNLIESLKRSNSAPILQGFGIAKPEQVKEALVLGCDGAISGSAIVKIIERNLDSQTQLLSELAKFVSVMKAATKS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: MDARF_CUCSA
Sequence: EAVAPYERPALSKNIFYLREIADADQLVEAIKLKDGRTLDADIVVVGVGGRPLVSLFKTSIPDVYAVGDVATYPLKLYNELRRVEHVDHARLSIEEYDYLPYFYSRTFNLAWQFYGDNVGETVLFPDNFGTYWIKVVGVFLEGGTPDEYKVARVQPPVESLDQLAK
What is the function of this protein?
Catalyzes the conversion of monodehydroascorbate to ascorbate, oxidizing NADH in the process.
What are the official names of this protein?
Monodehydroascorbate reductase, fruit isozyme, MDAR fruit, Ascorbate free radical reductase fruit, AFR reductase fruit.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
Protein: Y112_ADE02
Sequence: MLPYISWNTQRAPLRLRHLRHVRLRAHPPHAMGSPTQPIRARACRPRMAAGARLARMQDRLLRRAPAARGLYRGRRPPGRDAARPTTAILFAQGRPPLLDQRAPTRRGSHQR
What are the official names of this protein?
Uncharacterized protein F-112.
Protein: NU2M_BRAFL
Sequence: MSPYISPLFSITMIMSVMLISSSGHWVFMWLGLELGTLAFIPILVWWHSSLEVEATVKYFIVQAMAAAVFFLGGMVSLSGDFMGGVNQLMGNIGDMMIMLAVVTKLGLAPFHYWVVDVVQGLNYIPGAVLLTWQKVPGLAVLTQLATCNNSSMLLLFGMVSALVGGLGGLGQTQMRKLLAFSSISHLGWLVVGCVAGSLLGLSYFTLYVVLSIPLFSILHMLNGGHLNQLRTGLMFNPLMSVLLGVGFLSLGGLPPFFGFFGKWLLLTHFVGQLLLGVSVVLITGTLISLFYYLRVSYLCIVVLGPQQIMSGLNWRKMQLSGLMSGLLVLNMLGLFLVGGASCLPK
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AMPA_ECOSE
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_MANSM
Sequence: MIEADRIISSNAQLGDEYIDRAIRPKLLTDYVGQPQVREQMGIFIQAAKLRQDALDHLLIFGPPGLGKTTLANIVANEMGVNIRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPAIEEVLYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYSVEDLTSIVARSAGCLNLEMSDGASHEIARRSRGTPRIANRLLRRVRDFADVKNAGIISEDIAKSALSMLDIDQAGFDYLDRKLLSAVIERFDGGPVGLDNLAAAIGEERDTIEDVLEPYLIQQGFLQRTPRGRIATSRTYRHFGLDKLTE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MOMT4_SOLLC
Sequence: MALSMDNIVISNEEEIYMMKAMHIPCGLYLNMVLRAAIELDLFEIIAKSTTQKLSSYEIASQIPTKNPNASSLVLERILRFLASQSFLTCNITKNDDGNVHTSYNLTPLSQSLISDKDGSSLAPFLLLHSESVVVNSCFLLKDAILQGEVPFNKAYGMNAFEYTKKDSRMNGLFNKAMQNVTCIEMKKIVECYNGFEGVKETIDVGGGLGISLASIISKYPNIKGINFDLPHVIKDAPTYEGIEHVGGDMLKSVPQGELIILKEILHNWDDEDCVKILKNCWRALPNDGKVVVIEQIQPEYPETNLLSKHLFALDISMMIMFHGGKERTKQQFEDLAKQAGFTSIKVMARAYYYWVIEFYKY
What is the function of this protein?
Flavonoid 3'-O-methyltransferase involved in the biosynthesis of polymethoxylated flavonoids natural products such as myricetin derivatives, aroma compounds possessing antioxidant properties and exhibiting pharmacological activities such as anti-carcinogen, anti-viral, anti-thrombotic, anti-diabetic, anti-atherosclerotic, and anti-inflammatory effects (PubMed:25128240).  Catalyzes S-adenosylmethionine-dependent regioselective 3'-O-methylation of flavonoids; active on various hydroxylated flavonoid substrates, including myricetin, thus producing 3'-methyl myricetin (laricitrin) (PubMed:25128240).
What are the official names of this protein?
Myricetin 3'-O-methyltransferase 4, SlMOMT4.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: UB2D3_RAT
Sequence: MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWTQKYAM
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination.  Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation.  Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin.  Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin.  Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA.  Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase.  Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair.  Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus.  In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53.  Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis.  In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes.  In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.  Together with RNF135, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 D3, (E3-independent) E2 ubiquitin-conjugating enzyme D3, E2 ubiquitin-conjugating enzyme D3, Phosphoarginine phosphatase, PAPase, Ubiquitin carrier protein D3, Ubiquitin-conjugating enzyme E2(17)KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-protein ligase D3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Protein: LSPA_BURTA
Sequence: MAKTLSKSSGGALAPWLGISLIVILFDQLTKIAVLKTFAYGAMHQLTPFFNLTLIYNRGAAFGFLATAGGWQRWAFTALGIGATLVICYLLKRHGHQRLFSLSLALILGGALGNVIDRLIYGHVIDFLDFHVGAWHWPAFNLADSAITVGAVLLIYDELRRVRGAR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DINJ_ECOLI
Sequence: MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDLFDKLGI
What is the function of this protein?
Cell death governed by the MazE-MazF and DinJ-YafQ TA systems seems to play a role in biofilm formation (PubMed:19707553).
What are the official names of this protein?
Antitoxin DinJ.
What is the protein family that this protein belongs to?
Belongs to the RelB/DinJ antitoxin family.
Protein: ENY2_DROYA
Sequence: MSVSAAVDQYTVLTGDRSKIKDLLCSRLTECGWRDEVRLMCRNILLEKGTNNSFTVEQLITEVTPKARTLVPDAVKKELLMKIRTILTENEEEADEAEEEP
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes.  The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Involved in transcription elongation by recruiting the THO complex onto nascent mRNA.  The AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
What are the official names of this protein?
Enhancer of yellow 2 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm.
Protein: HRB1_YEAST
Sequence: MSDQERGSENNNRSRSRSRSPVRRRMSDDHGYERDNHLSRRSGNYNGRRKFADTYRGSRDRGEYRGGRERSDYRERERFNNRDNPRSRDRYDDRRRGRDVTGRYGNRRDDYPRSFRSRHNTRDDSRRGGFGSSGARGDYGPLLARELDSTYEEKVNRNYSNSIFVGNLTYDSTPEDLTEFFSQIGKVVRADIITSRGHHRGMGTVEFTNSDDVDRAIRQYDGAFFMDRKIFVRQDNPPPSNNIKERKALDRGELRHNRKTHEVIVKNLPASVNWQALKDIFKECGNVAHADVELDGDGVSTGSGTVSFYDIKDLHRAIEKYNGYSIEGNVLDVKSKESVHNHSDGDDVDIPMDDSPVNEEARKFTENVVGGGERNRLIYCSNLPFSTAKSDLYDLFETIGKVNNAELRYDSKGAPTGIAVVEYDNVDDADVCIERLNNYNYGGCDLDISYAKRL
What is the function of this protein?
Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus (PubMed:14676199, PubMed:14769921, PubMed:24452287).  Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded.  On correctly spliced mRNAs, GBP2 and HRB1 recruit MEX67 to allow nuclear export.  On faulty mRNAs, GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation (PubMed:24452287).
What are the official names of this protein?
Serine/arginine (SR)-type shuttling mRNA binding protein HRB1, Hypothetical RNA-binding protein 1, Polyadenylate-binding protein HRB1, Protein TOM34.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus. Cytoplasm, P-body. Cytoplasm, Stress granule. Note=Shuttles between nucleus and cytoplasm (PubMed:9499403). Nuclear at steady state and its import is mediated by the karyopherin MTR10. Export is dependent on active transcription and the export of mRNAs in general. Depends on MFT1 and HPR1 for nuclear export (PubMed:14676199).
Protein: CPSF6_HUMAN
Sequence: MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR
What is the function of this protein?
(Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro).
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 6, Cleavage and polyadenylation specificity factor 68 kDa subunit, CPSF 68 kDa subunit, Cleavage factor Im complex 68 kDa subunit, CFIm68, Pre-mRNA cleavage factor Im 68 kDa subunit, Protein HPBRII-4/7.
What is the protein family that this protein belongs to?
Belongs to the RRM CPSF6/7 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs) (PubMed:17267687). Distribution in speckles and paraspeckles varies during the cell cycle (PubMed:17267687). Associates at sites of active transcription on nascent perichromatin fibrils (PFs) and perichromatin granules (PubMed:17267687). Nuclear import is mediated via interaction with TNPO3 independently of CPSF6 phosphorylation status (PubMed:30916345).
Protein: GPMA_LEIXX
Sequence: MSASHALILLRHGNSEWNRQNLFTGWVDVRLSEQGVAEAKRAGELLAESGLVPDILYTSLLTRAIQTANHALDAADRLWIPVVRSWRLNERHYGALQGLDKAETLEKYGPEQFQLWRRSFDVPPPPLADDSEWSQADDPRYADLGADLPRTECLKDVIARMLPFWESDITTSLSAGKTVLVTAHGNSLRALVKHLDGISDDDIAELNIPTGVPLVYKLDDSFKPVEPAAYLDPEAAAVGAAAVAAQGKK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.