PharMolix/UniProtQA huggingface dataset:
Protein: PTH_THET2
Sequence: MFLVVGQGNPGERYARTRHNLGFMVLDRLGLSFRPRGEALVAEAEGGLFLKPLTYYNLTGRAVAPLARFYKIPPERILVVHDEMDLPLGRIRFKAGGSAAGNRGVLSIEEALGTRAFHRLRLGIGKPPDPSRGAEYVLSPFREEELPVVERVLEAAKEAVWCWVREGLPPCAGRFNGLDLSLG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURE_COREF
Sequence: MCADTPHHPTPVHTEEAMAITLGELARTIGGELFNAPDQDLEIHNIGLDSSTLAKKAPIFAAVPGSRKHGAEFADTDRAAGALAVLTDRDGATILDRKGDTRPRLIVDDVREVLGVASSSVYGDPSRDLVLIGVTGTSGKTTTSYLLERGLMEAGYKVGLIGTTGTRIDGEPVPTKLTTPEAPTLQKLFYRMRQHGVTHVVMEVSSHALSLGRVSGSHFNVAAFTNLSQDHLDFHDTMEEYFDAKALFFRAGSPLAADHQVVCIDDEWGTRMAEVAGNAQTVATTGKRADFTAGLVTVKETGEQSFTVTVPDHGEVPVTLALPGAFNVANATLALAAAVRAGVDPVAFARGMAQVAVPGRMERIDEGQDFLAVVDYAHKPAAVAAVLDTLRTQIDGRLGVVIGAGGDRDATKRAPMGELSARRADLVIVTDDNPRSEVPATIRAAVMEGARRGAAEADHEVEVREIGDRAEAIRALIEWAGPGDGIVVAGKGHEVGQLIAGVTHHFDDREQVREALRHTQSDGEGK
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPO_SCHPO
Sequence: MDDEEGNATLIDEISVLEARRDVLLDELKSLDNATLSDLVQKPELSKNLSVNNEFLKETPLNQPALHYDRLSGISFFQPNDPEELSRKTLLVKNKKTGAIETAPSIPLLGVRFDIMLNPVNIGFTNLSENPISSASGMDEELEGGNRFDVPYYIIFRVFHDSFALYKYTIPSFLNIQEWADEYLTGKNPERFRIFLWKVDKLLTAYICRKNALLQINKSLTIDGTNISANLSCTHLVIQIPKVIQATLVCSSESTRVVKSRIYQYSDENWKRDHRLELSLLDNKRWVNILVSHLTAPESHASL
What is the function of this protein?
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis.  Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore.  COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
What are the official names of this protein?
Inner kinetochore subunit mal2, CENP-O homolog, Constitutive centromere-associated network protein mal2, Sim4 complex subunit mal2.
What is the protein family that this protein belongs to?
Belongs to the CENP-O/MCM21 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere.
Protein: CEEP_DICTD
Sequence: MDLKVLKSEIFEHLNNKIIPFWEELKDENNGGYISYVGFDLKPDPYAPKGLVLTSRILWFFSRLYNQLRKEEFINFADHSYKFLIKSFLDKENKGFYWMVDYKGEPIDKRKHLYGQAFVLYGLSEYYKATQKKESLDLALEIYKIIEEVCKNDVGYKEEFDEKWNPKENIIVSEYGIICERSMNTLLHILEAYTNLFTATYDQSIKKKIEDLIILFKEKIYDSKTNHLYVFFDKKMNPIIDAISYGHDIEATWLIDEALRYIDNNKLIKEMSEINLKIAEKVLEEAFESGSLLNERVRGIVDKNRIWWVQAEALVGFLNAYQKSKLDKFLKAVFELWEFIKDFLVDKRAQGEWFWKLDENYIPSPMPEVDLWKCPYHNGRMCLEVIKRI
What is the function of this protein?
Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).  Catalyzes epimerization but also isomerization for beta-1,4- and alpha-1,4-gluco-oligosaccharides.  Can use cellobiose, lactose, cellotriose, maltose and maltotriose.
What are the official names of this protein?
Cellobiose 2-epimerase, CE.
What is the protein family that this protein belongs to?
Belongs to the cellobiose 2-epimerase family.
Protein: TEPA_BACSU
Sequence: MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIHCLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLAIAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQTFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDHAGGVGQAINKLNELIDEARKEEGRMIQ
What is the function of this protein?
Required for efficient translocation of pre-proteins across the membrane.
What are the official names of this protein?
Translocation-enhancing protein TepA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family. TepA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHCB_ANASL
Sequence: MTLDVFTKVVSQADSRG
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex (phycobilisome, PBS).  Phycocyanin is the major phycobiliprotein in the PBS rod.
What are the official names of this protein?
C-phycocyanin beta subunit.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Part of the phycobilisome rod.
Protein: CYSG_PSEP1
Sequence: MDYLPLFHKLQGGRVLVVGGGEIALRKARLLADAGGVLRVVAPDVDGQLAALAREGGGEVLVRGYQAADLVGCRLVIAATDDPGLNAQVSADAQALSVPVNVVDAPALCTVIFPAIVDRSPLVIAVSSGGDAPVLARLIRAKLEAWIPSAYGELAGLAARFRHKVKSLYPDVNQRRGFWETVFQGPIAERQLAGQGAEAERLLQAMVDGAPVQQGGEVYLVGAGPGDPDLLTFRALRLMQQADVVLYDRLVAPAIIDMCRRDAERIYVGKRRADHSVPQDQINRLLVDLARQGKRVLRLKGGDPFIFGRGGEEIEELAEHGIPFQVVPGITAASGCSAYGGIPLTHRDYAQSVRFVTGHLKDGTSNLPWTDLVAPAQTLVFYMGLVGLPTICAELIRHGRAASTPAALVQQGTTRNQRVFTGTLADLPDLVAQHEVHAPTLVIVGEVVQLRDKLAWFEGSQNS
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: PEPX_STRPS
Sequence: MRFNQYSYINFPKENVLSELKKCGFDLQNTANHKDSLETFLRRFFFTYQDTNYPLSILAADKKTDLLTFFQSEDELTADIFYTVAFQLLGFSYLVDFEDSDVFRKETGFPIIYGDLIENLYQLLNTRTKKGNTLIDQLVSDGLIPEDNDYHYFNGKSLATFSNQDVIREVVYVESRVDTDQKGLSDLVKVSIIRPRFDGKIPAIMTASPYHQGTNDKASDKALYKMEGELEVKLPHKIELEKPQLNLVQPQGKAELIAEAEEKLTHINSSYTLNDYFLPRGFANLYVSGVGTKDSTGFMTNGDYQQIEAYKNVIDWLNGRCRAFTDHTRQRQVKADWSNGKVATTGLSYLGTMSNGLATTGVDGLEVIIAEAGISSWYNYYRENGLVTSPGGYPGEDFDSLAELTYSRNLLASDYIRGNEAHQADLEKVKAQLDRKTGDYNQFWHDRNYLLNAHKVKAEVVFTHGSQDWNVKPLHVYQMFHALPTHIHKHLFFHNGAHVYMNNWQSIDFRESINALLTKKLLGQETDFQLPTVIWQDNTAPQTWLSLDNFGGQENCETFSLGQEEQAIQNQYPDKDFERYGKTYQTFNTELYQGKANQITINLPVTKDLHLNGRAQLNLRIKSSTNKGLLSAQLLEFGQKKYLQPYPAILSARTIDNGRYHMLENLCELPFRPEAQRVVTKGYLNLQNRNDLLLVEDITADEWMDVQFELQPTIYKLKEGDTLRLVLYTTDFEITIRDNTDYHLTVDLAQSMLTLPC
What is the function of this protein?
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Xaa-Pro dipeptidyl-peptidase, X-Pro dipeptidyl-peptidase, X-prolyl-dipeptidyl aminopeptidase, X-PDAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYW32_THEKO
Sequence: MKAKREALQSLFTAMRDGKVDGDIIDLLLLINSIKGIYTTSSCSGRIGIIEEPALGAKPLSRWLIKVHRPIEFEEAKEALKNAKEGIIFLKSQPPIFHVVAEDLEKARKLHELGLASGFKYTTFKVISKRYLVEINATEYLTAPLGRDGRVLVDDGYLRFAVEIGNEMLRRSKGRLPRLEENFRRLREELGTDELFYELVEEYKIRENWELP
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway.  Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
What are the official names of this protein?
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2, tRNA wyosine derivatives biosynthesis protein Taw3 2.
What is the protein family that this protein belongs to?
Belongs to the TYW3 family.
Protein: RUVB_CAMLR
Sequence: MDRIVEIEKFSPDETYETSLRPSNFDGYIGQENIKKNLEIFIKAAKKRNECLDHILFSGPAGLGKTTLANIISYEMNANIKTTAAPMIEKSGDLAAILTNLSEGDILFIDEIHRLSPAIEEVLYPAMEDFRLDIIIGSGPAAQTIKIDLPKFTLIGATTRAGMLSNPLRDRFGMQFRLEFYKNEELAIILEKAALKLNKTCEKNAALEIAKRSRSTPRIALRLLKRVRDFADVNDEEIISEKRAKEALDSLGVNELGFDAMDLRYLELLTEAKRKPIGLSSIAAALSEDENTIEDVIEPYLLANGYIERTAKGRIASLKSFDVLKLKYNKGLFDEK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MURB_RHIE6
Sequence: MKQVNGEKLLASLGDGVKDIRGRITPDAPMDRVTWFRAGGLAELMFQPHDVDDLIAFLKILPEEVPLTVIGVGSNILVRDGGIPGVVLRLSAKGFGFVELAGENRILAGAICPDKHVAAMAMDNGIGGFHFYYGIPGAIGGAARMNAGANGVETRERLVEVNAVDRKGNKHVLSNAEMGYSYRHSAASADLIFTSVLFEGYPEDRAQIRAEMDAVRNHRETVQPVREKTGGSTFKNPPGHSAWKLIDEAGCRGLVIGGAQMSSLHCNFMINMGQATGYDLEYLGEQVRREVFEKDGIKLEWEIKRLGVFMPGREVRPFQGVTSE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPYM_FELCA
Sequence: MSKPHSDVGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVEILKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPIRYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENVLWLDYKNICKVVEVGSKVYVDDGLISLLVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAMFHRKLFEELVRGSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKARGFFKHGDVVIVLTGWRPGSGFTNTMRVVPVP
What is the function of this protein?
Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth.  In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
What are the official names of this protein?
Pyruvate kinase PKM, Pyruvate kinase muscle isozyme, Threonine-protein kinase PKM2, Tyrosine-protein kinase PKM2.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
What are the subcellular locations of this protein?
[Isoform M2]: Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli. SUBCELLULAR LOCATION: [Isoform M1]: Cytoplasm.
Protein: RNF8A_XENLA
Sequence: MTDEGPGMCWCLRRCGRNTEDLLLPDGEEVTLGRGLGVTYQLKPTLCPLMISRTHCLFKQNTGGEWTVTDNKSLNGVWRNKERLEPHKAYTLSEGALIQLGVPPPNMESAEFEYMLVREHLEKLSGSLIRPLPDKTKATRTKRKFTSEDTDASGNEGPSNFSIPKFYRVSREDEDSAKSSHTTDLYKQPTVEPTASGTESRLNDSVEAEVVAPTQQQCRSTLQLSRVRQTMEEIRRLNVQMQEKQMEMQEKLNSPLENQVGANSVLAVQKELRALHNHLSNEQEQHMQSVKELKEIFEEEQQSMGSRKQVEEEHLKEQLAQALQEHTQLMQELNRSKNDFEQIIEAKNKELQETKEEKEKVFAQKEEVLNHMNDVLDNELQCIICSEHFIEAVTLNCAHSFCSYCIKSWKKRKEECPICRQEIVTETRSLVLDNCIDSMVDKLSPEMKNRRAALILERKEMVQAEESNPVLVVSDSSSFLSDTFYISSSSSDSDELGNDFWMRSEEEEYEETLFGCGTDELDSSDFESDDDEEEDSFLII
What is the function of this protein?
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.  Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53bp1 and brca1 ionizing radiation-induced foci (IRIF).  H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates.  Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins.  In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.
What are the official names of this protein?
E3 ubiquitin-protein ligase rnf8-A, RING finger protein 8-A, RING-type E3 ubiquitin transferase rnf8-A.
What is the protein family that this protein belongs to?
Belongs to the RNF8 family.
What are the subcellular locations of this protein?
Nucleus. Note=Following DNA double-strand breaks, recruited to the sites of damage.
Protein: Y4KE_SINFN
Sequence: MVAVADWFLTGSDAMPAGQAKDPSEAFSNADAPLGSLVMLASPNGSYDTPFGTKVKTTRPSIANLKTAYVAWLERLKLNPQSRGVFYFCGHGISDGETQYLVADDFGEDEADIWNAVFQLTMTVQATLRKSKASLFYFIDACMELSEEIINQLEDPKALIGGSRRGALTTTDWAIVRATTANRLAYAPDGGVAHFTQALLSALRGHCGVEHPSGNGYSVDVARLRAAISEFLEFLQPEGMADRQKIGKTEGDGNWTVPLHVLSKRPSVMLELDVLPQGFRPIAQAFMEDTALVRDTKPLATGPVRFVREHGEWTYGTNSTDPTSFPEKIYNRKLLTNAAVRRLIKVD
What are the official names of this protein?
Uncharacterized protein y4kE.
Protein: G3PB_PEA
Sequence: MATHAALASTRIPTNTRFPSKTSHSFPSQCASKRLEVGEFSGLKSTSCISYVHSARDSSFYDVVAAQLTSKANGSTAVKGVTVAKLKVAINGFGRIGRNFLRCWHGRKDSPLEVIVVNDSGGVKNASHLLKYDSMLGTFKAEVKILNNETITVDGKPIKVVSSRDPLKLPWAELGIDIVIEGTGVFVDGPGAGKHIQAGAKKVIITAPAKGADIPTYVIGVNEQDYGHEVADIISNASCTTNCLAPFAKVLDEEFGIVKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTSTGAAKAVSLVLPQLKGKLNGIALRVPTPNVSVVDLVVNVAKKGISAEDVNAAFRKAAEGPLKGILDVCDVPLVSVDFRCSDVSTTIDSSLTMVMGDDMVKVVAWYDNEWGYSQRVVDLAHLVANKWPGTPKVGSGDPLEDFCETNPADEECKVYE
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase B, chloroplastic, NADP-dependent glyceraldehydephosphate dehydrogenase subunit B.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TORD_SHELP
Sequence: MNKPSIDQTPANQARARVYRLLSDLFAKEIDHQRLQSLQSAEAQAFFDLLAGEPRLAPEVNIIQEVLAELGDEASLLNLAADYCGLFLVGGKQSANPYAGLYLTPEGDEEQPQLFGPQHQEMLALLKQSKLGVQSDFPEPADHISVILAYVAQQATSLDDKAQQRFIAKYLDAWLAEFAKRVSDRDPGRFYQALARLTQIWVSLDCEALGA
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALG11_MOUSE
Sequence: MAADTGSWCVYAVLRFFYSLFFPGLMICGVLCVYLVIGLWVIRWHLQRKKKSVSTSKNGKEQTVVAFFHPYCNAGGGGERVLWCALRALQKKYPEAVYVVYTGDINVSGQQILDGAFRRFNIKLAHPVQFVFLRKRYLVEDSRYPHFTLLGQSLGSILLGWEALMQRVPDVYIDSMGYAFTLPLFKYVGGCRVGSYVHYPTISTDMLSVVKNQNPGFNNAAFISRNALLSKAKLIYYYLFAFVYGLVGSCSDIVMVNSSWTLNHILSLWKVGHCTNIVYPPCDVQTFLDIPLHEKKVTPGHLLVSIGQFRPEKNHALQIKAFAKLLNEKAAELGHSLKLVLIGGCRNKDDEFRVNQLRSLSENLGVQENVEFKINISFDELKNYLSEATIGLHTMWNEHFGIGVVECMAAGTVILAHNSGGPKLDIVIPHEGQITGFLAESEEGYADSMAHILSLSAEERLQIRKNARASISRFSDQEFEVAFLCSMEKLLT
What is the function of this protein?
Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.  Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain (By similarity).
What are the official names of this protein?
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase, Asparagine-linked glycosylation protein 11 homolog, Glycolipid 2-alpha-mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TRUB_BURP6
Sequence: MARRALDGVLLLDKPVGLSSNDALMRAKRLYQVKKAGHTGTLDPLASGLLPLCFGEATKFSQDLLEADKTYEATMRLGVRTTTGDAEGDVLDTRDVSCDEAAVRAALARFVGEIVQVPPMYSALKRDGKPLYEYARAGQTVEREGRTVTIRALALVSCALPDVTFRVTCSKGTYVRTLAEDIGEALGCGAHLTMLRRTGVGPLTLEHAVTLDALDAATQDERDARLAPVDALLSTFPCVKLDAALATRFLHGQRLKLSELAARPDAAEGGRVRVYDADDRLLGVARASEGVLAPERLVVTGA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: GBLP_DROME
Sequence: MSETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSPDGSLCTSGGKDSKALLWDLNDGKNLYTLEHNDIINALCFSPNRYWLCVAYGPSIKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVWQVSVSAH
What is the function of this protein?
Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules.  Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-like protein, Receptor of activated protein kinase C homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
Protein: Y1391_AQUAE
Sequence: MTQWKRRSRRKGMRTRNNKQLIKLILTKSREICNTIRPSQYNKRGRPRVYEDHLIVAALLIKILENLSLRDLEERLKDLFPKVPDFTTLHYRFRKLNRGYLKELIHRTAKEIMEKLQAKEFYCLIADGTGFGYAQAYELKWKKGKELRNVKSHVKTEVLVGVVRNKAIVVDINTGKSYADENMLLRSMLKELGFRARYFLGDAYYGKSAGVLEEIKKLRMESIVPVRDTAHTRVRNMYRLWAKRNYEIRRKVYRKNRYRVEQVIGIVKNRFGDRDNVYDFEIASLYVLGRFVLYNLILLLKLLLLCLNLLRITWASSRFIL
What are the official names of this protein?
Uncharacterized protein aq_1391/aq_1640/aq_aa40.
Protein: RL2_BEUC1
Sequence: MGIRKYKPTTPGRRGSSVADFVEVTRSEPEKSLVRPLSKSGGRNSTGRITSRRRGGGHKRAYRVIDFRRHDKDGVPAKVAHIEYDPNRTARIALLHYADGEKRYIVAPNRLKQGDRIENGPAADIKPGNNLPLRNIPTGTVIHAVELRPGGGAKIARSAGSSVQLVAKDGPYAQLRMPSGEIRNVDARCRATIGEVGNAEQSNINWGKAGRMRWKGKRPSVRGVAMNPVDHPHGGGEGKTSGGRHPVSPWGQPEGRTRRPGKPSDKLIVRRRRTGKKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: CAPI_STAAU
Sequence: MKILITGTAGFIGSHLAKKLIKQGHYVIGVDSINDYYSVSLKEDRLKSIGKENFTFNKVKLENYDDLSKVFVDEQPEVVVNLAAQAGVRYSIENPRTYIDSNIVGFMNILECSRHFNIQNLIYASSSSVYGANTSKPFSTSDNIDHPLSLYAATKKSNELMAHTYSHLYNLPTTGLRFFTVYGPWGRPDMALFKFTKAIVNDQAIDVYNHGNMMRDFTYVDDIVEAISRLVKKPASPNKEWSGADPDPGSSYAPYKVYNIGNNSPVRLMEFVEAIENKLGKEARKNYMDLQPGDVPETYANVDDLFRDIDFKPETTIQDGVNKFVDWYLEYYKK
What is the function of this protein?
Required for the biosynthesis of type 1 capsular polysaccharide.
What are the official names of this protein?
Protein CapI.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: ASPP_BACSU
Sequence: MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSGAFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSLISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANFIISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPIVSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSLPFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVNKDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKDLNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKEDVSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKYTGLPKAAIDYDK
What is the function of this protein?
Uptake of L-aspartate with the concomitant import of a proton.  Can also transport aspartate hydroxamate and L-glutamate with lower affinity and efficiency.
What are the official names of this protein?
Aspartate-proton symporter, L-aspartate transporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. AGT (TC 2.A.3.11) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CDK20_MOUSE
Sequence: MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEIEDSQYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGGRLYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPSPRVWPEITELPDYNKISFKEQAPVPLEEVLPDASPQALDLLGQFLLYPPRQRIAASQALLHQYFFTAPLPAHPSELPIPQRPGGPAPKAHPGPPHVHDFHVDRPLEESLLNPELIRPFIPEG
What is the function of this protein?
Involved in cell growth.  Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).  Required for high-level Shh responses in the developing neural tube.  Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling.
What are the official names of this protein?
Cyclin-dependent kinase 20, CDK-activating kinase p42, CAK-kinase p42, CDK-related protein kinase PNQLARE, Cell cycle-related kinase, Cell division protein kinase 20, Cyclin-dependent protein kinase H, Cyclin-kinase-activating kinase p42.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium.
Protein: CSTM5_ARATH
Sequence: MSQYSQNQYAGAYPTPPVSTGPYVAPPPLGYPTNDTTHATVAPVETKSKGEAADGFLKGCLATMLACCVLDACIF
What is the function of this protein?
Involved in resistance to abiotic stress.
What are the official names of this protein?
Protein CYSTEINE-RICH TRANSMEMBRANE MODULE 5, AthCYSTM5.
What is the protein family that this protein belongs to?
Belongs to the CYSTM1 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Nucleus.