PharMolix/UniProtQA huggingface dataset:
Protein: LON_METBF
Sequence: MRRLTMYPEQPDENRESIVMPLFEVVVYPKSRAKFLADKVTGEILLNDMKNAESVSAIGLTVKNGTKASDLSEESLYKIGNLLNITYVQPSDDGYLVVAKGIERVEAVSLYQKNGLFYATYRPVHDLPDFDEDAETEVMANIKKTIHEISARFQGSEQFTKSIDKMDSIDQIMGFVMPYIPVKLAEKQRLLELASVRERYLLFLHILTKHKENINLQIEMAKKVTDKISKSNREAMLREQLKVIQEELNEGDDSASGDAAYREKIENSTMPDEVKKKAFSELKKLETGGSHNPEAPGIRNYLDLLLDLPWITEEKKSIDIAEARRVLESNHNGLEKVKERIIQHLAVMKLKHEKQGSILLLIGPPGTGKTSLGKSIADALGRKYIRISLGGVKDEAEIRGHRRTYIGALPGRIIQGMRKAGTKNPVFILDEVDKLSASYSGDPASALLEVLDPEQNSTFSDHYLEIPYDLSDVLFIATANSMANIPWPLLDRMETIEISGYTKNEKLAIAKDHLVPCILEDHGLDAEKLKIEDEALKVIIDKYTREAGVRGLKKQLAKTARFVSEKIVSGKADLPYVVRADMLKEILGKEIIRQEEARKENVPGVVTGLAWTPVGGDILFIEGTFMPGSGKLTLTGQLGDVMKESAKISLSLVRSRLANTANSFDFTSSDIHIHVPSGATPKDGPSAGVTLFTALTSLIIGKAVDPKLAMTGEITLSGAVLPVGGIKEKVLAAHRAGIKKIILPKENERDLEDVPEDARNELQFVPVETIEEVLREALDIDLPRPVVPSSYPGSSYAPAHSV
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins.  Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress.  Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long.  Binds to DNA in a double-stranded, site-specific manner.
What are the official names of this protein?
Lon protease, ATP-dependent protease La.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_XANCP
Sequence: MATVGMNDVKNGMKILVNNEPAVITETEYVKPGKGQAFTRMKYRFIKSGRVVEMTMKATDDVEVADVVDTDMRYLYTDGEYWHFMDPESFEQVQADKAGMGGAEKWLKGEEDCIVTLWNGAPIWVQPPNFVELKITETDPGVRGDTSGGGGKPATLETGAVVRVPLFVNQDEVIKVDTRSGEYSARVK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2433_CLOK5
Sequence: MIVTTTNCIEGKKVLEYKGIVFGEVISGVDAIKDIAAGFTNFFGGRSKSYEGELIQAREEALEELKNRAYAVGANAVIGIDIDYEVLGQGGNMLMVTASGTAVVVE
What are the official names of this protein?
UPF0145 protein CKL_2433.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: RPD3B_ARATH
Sequence: MDGVTYQRFPTVKIRELKDDYAKFELRETDVSMANALRRVMISEVPTMAIHLVKIEVNSSVLNDEFIAQRLSLIPLTSERAMSMRFCQDCEDCNGDEHCEFCSVEFPLSAKCVTDQTLDVTSRDLYSADPTVTPVDFTSNSSTSDSSEHKGIIIAKLRRGQELKLKALARKGIGKDHAKWSPAATVTYMYEPDIIINEEMMNTLTDEEKIDLIESSPTKVFGIDPVTGQVVVVDPEAYTYDEEVIKKAEAMGKPGLIEIHPKHDSFVFTVESTGALKASQLVLNAIDILKQKLDAIRLSDNTVEADDQFGELGAHMREG
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements.
What are the official names of this protein?
DNA-directed RNA polymerases IV and V subunit 3B, DNA-directed RNA polymerase II 36 kDa polypeptide B, DNA-directed RNA polymerase II subunit RPB3-B, RNA polymerase II subunit 3-B, RNA polymerase II subunit B3-B.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YPEL2_MOUSE
Sequence: MVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD
What are the official names of this protein?
Protein yippee-like 2.
What is the protein family that this protein belongs to?
Belongs to the yippee family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DRC1_MACFA
Sequence: MNPPGSLAGLDPNLDEHLSTQILAPSVHSDNPQERIQARRLRIAARLEPRRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWERALQAHNAKELEYLTNRMKKVEDYEKQLNRQRIWDCEEYNTIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTLDYKRLVLQFKELQKAMRHFALIDDEKFREIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWTAPDFWFLKNVGPISQQPQKSATQIVEEMLMHTEEEEAEEAASEPESYLDLPKQVSEKTTKKILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKSCSQASMEKASMEETSMGSELELAEQTEMEGAKEESLVEGEKEEEEETPPSPWDIHPNDVLKILEAFVMGLKKPRDSRAPPRVQKNMRNNSKDSEYWQALTTVIPSSKQNLWDALYTALEKYHIVLTQRAKLLLENSSLEQRNTELQALLQQYLNSKINSELQVPPTQVLRVPTK
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.  Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes.  Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
What are the official names of this protein?
Dynein regulatory complex protein 1, Coiled-coil domain-containing protein 164.
What is the protein family that this protein belongs to?
Belongs to the DRC1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: PHS_DECAR
Sequence: MATSCNLADRQCTPCEGGIAPLENSVAAVMLDTLPGWTLDGQRLDKTYVFRNHYEAMAFVNAIAWVSHRENHHPELIVGYKDVRVRYWTHAIGGLSENDFICAAKLEKLLEI
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: AIM36_YEAST
Sequence: MLRPLRKSVLASCRHCFKVCGGLPQKQLPLFSPLLLRARYSSTDSSTKRSNKSDKIDAPGFKKIFLVAIIGTVIFVKTVQSLDKNKPKTTLSEEEFENVVKGLKRRVAIFPQGEVDIKFSLSPSIEETRKVLQKSQGDDINELQFVDPVKVIDYYRTLRDDRYEALLNEYYKKYGCDTYAYNLPTGMLVMLLGRYFKENFKTGDKLVVVNFPHSIADATRFENEVSIVSKIFVPRKLSGSDVCKYYETVGKADII
What are the official names of this protein?
Altered inheritance of mitochondria protein 36, mitochondrial, Found in mitochondrial proteome protein 39.
What is the protein family that this protein belongs to?
Belongs to the AIM36 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: CYDC_HAEIN
Sequence: MRTLLPFIRLFKFAKFPLILGLVLMILGLGSSMGLLTVSGWFLAATAIAGLGTLFNFFYPSASVRGLAIGRTVMRYFEKIVTHDATFRILSKLRVQVFEKIIPLSPAVLNRYRNSDLLNRLVSDVDTLDSLYLRLLAPFFTAVFVIIAMMIGLSFINIPLALGLGLFLLILLMIIPTVFYRLGQQFGERLIQARATYRTQFLEFIQAQAELLLFNAEDKLKEKMLVTEKTWQEDQAKEAKLSGFSTALVLFLNGLLISGMLWFASNADFGTDEYHTAYIALFTFAALAAFEIIMPLGAAFLHIGQVIAAAERVTEIIEQKPLVEFNGNEEFETKVRLISAKNLNFSYPEQETLVLKNLTLDLEQGKKIAILGKTGSGKSSLLQLLVRNYDANQGELLLAEKPISAYSEETLRHQICFLTQRVHVFSDTLRQNLQFASADKISDEQMIEMLHQVGLSKLLEQEGKGLNLWLGDGGRPLSGGEQRRLGLARILLNNASILLLDEPTEGLDRETERQILRLILQHAENKTLIIVTHRLSSIEQFDKICVIDNGRLIEEGDYNSLITKENGFFKRLIERV
What is the function of this protein?
Part of the ABC transporter complex CydDC that exports the reduced low-molecular-weight thiols cysteine and glutathione to the periplasm.  Export of these thiol-containing redox-active molecules may be crucial for redox homeostasis in the periplasm, permitting correct assembly of various respiratory complexes and formation of correct disulfide bonds in periplasmic and secreted proteins.  CydC contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Required for the assembly of functional cytochrome bd-type quinol oxidases and periplasmic c-type cytochromes.
What are the official names of this protein?
Glutathione/L-cysteine transport system ATP-binding/permease protein CydC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3.A.1.129.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HYPK_MOUSE
Sequence: MATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAERSLREHMGNVVEALIALTN
What is the function of this protein?
Component of several N-terminal acetyltransferase complexes (By similarity).  Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex) (By similarity).  Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex (By similarity).  May play a role in the NatA complex-mediated N-terminal acetylation of PCNP (By similarity).
What are the official names of this protein?
Huntingtin-interacting protein K, Huntingtin yeast partner K.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Within the NatA/HYPK complex, may localize to ribosomes.
Protein: GRAM4_MOUSE
Sequence: MGIASHSAFRERESSPTGASLDASPRPWDKGLSGREPPRHVQVRPRSAVLNMLRRLDRIRFRGHKREDLLDLAESPNASDTECGDEIPLKTPRPSPRDSEELRDPAGPGTLIMAAGVQDFNRTEFDRLNEIKGHLEIALLEKHFLQEELRKLREETNSEMLRQELDRERQRRIELEQKMQEVLKARSEEQPAQPQQPPKGQSQASNGTGTERRSQGLASRVQKWFYERFGEYIEDFRFQPEENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSIYTSAIAFTVYMNAVWHGWAIPMFLFLAILRLSLNYLIARGWRIQWSIVPEVSEAVEPAKEDLTVSEKFQLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPETTQKLYVALWAAFLASCFFPYRLVGLAVGLYAGIKFFLIDFIFKRCPRLRAKYDTPYIIWRSLPTDPQLKERAGATVSRRLQTASSRSYVSSAPAGLSKDEDAGRFHSTKKGNFHEIFNLTENERPLAVCENGWRCCLINRDRKMPTDYIRNGVLYVTENYLCFESSKSGSSKRNKVIKLMDITDIQKYKVLSVLPGSGMGIAVSTPSTQKPLVFGAMVHRDEAFETIFSQYVKITSAAASGGDS
What is the function of this protein?
Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (By similarity).  Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response (PubMed:25917084).
What are the official names of this protein?
GRAM domain-containing protein 4, Death-inducing protein.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with COX4I1.
Protein: MATK_ANTAN
Sequence: MEEIQRYLQPDRSQQHNFLYPLIFQEYIYALAHDHGLNRNRSILLENPGYDNKFSFLIVKRLITRMYQQNHFLISTNDSNKNSFLGCNKSLYSQMISEGFAFIAEIPFSLRLMSSLSSFEGKNIFKSHNLRSIHSTFPFLEDNFSHLNYVLDILIPYPVHLEILVQTLRYWVKDASSLHLLRFFLHEYWNLNSLITSKKPGYSFSKKNQRFFFFLYNSYVYECESTFVFLRNQSSHLRSTSFGALLERIYFYGKIERLVEVFAKDFQVTLWLFKDPFMHYVRYQGKSIMASKGTFLLMNKWKFYLVNFWQCHFSLCFHTGRIHINQLSNHSRDFMGYLSSVRLNPSMVRSQMLENSFLINNAIKKFDILVPIIPLIGSLAKENFCTVLGHPISKPVWSDLSDSDIIDRFGRICRNLFHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRTFLKRSGSELLEEFLTSEEQVLSLTFPRASSSLWGVYRSRIWYLDIFCINDLANYQ
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ALLR_SALTY
Sequence: MTEVRRRGRPGQAEPTAQKGAQALERGIAILQYLERSGGSSSVSDISGSLDLPLSTTFRLLKVLQAADFVYQDSQLGWWHIGLGVFNVGSAYIHNRDVLSVAGPFMHRLMLLSGETVNVAIRNGNEAVLIGQKECKSMVRMCAPLGSRLPLHASGAGKALLYPLTEEELVGIVVNTGLRRFTPTTLVDLPILLKNLEQAREQGYTVDQEEHVVGLNCIASAIYDDAGSVVAAISISGPASRLTEDRFISQGELVRDTAKDISTALGLKPPVA
What is the function of this protein?
Negative regulator of allantoin and glyoxylate utilization operons.  Binds to the gcl promoter and to the allS-allA intergenic region (By similarity).
What are the official names of this protein?
HTH-type transcriptional repressor AllR, Negative regulator of allantoin and glyoxylate utilization operons.
Protein: PDE6A_BOVIN
Sequence: MGEVTAEEVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNSVEESEIIFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNGIAELATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVPNTEEDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAIIMVVNKVDGPHFTENDEEILLKYLNFANLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYAGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIMNAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMVKYHVKCDNEEIQTILKTREVYGKEPWECEEEELAEILQGELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLDQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYETKMKGLEEEKQKQQAANQAAAGSQHGGKQPGGGPASKSCCVQ
What is the function of this protein?
Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP.  This protein participates in processes of transmission and amplification of the visual signal.
What are the official names of this protein?
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium, photoreceptor outer segment.
Protein: GLYC_LYCVA
Sequence: MGQIVTMFEALPHIIDEVINIVIIVLIVITGIKAVYNFATCGIFALISFLLLAGRSCGMYGLKGPDIYKGVYQFKSVEFDMSHLNLTMPNACSANNSHHYISMGTSGLELTFTNDSIISHNFCNLTSAFNKKTFDHTLMSIVSSLHLSIRGNSNYKAVSCDFNNGITIQYNLTFSDAQSAQSQCRTFRGRVLDMFRTAFGGKYMRSGWGWTGSDGKTTWCSQTSYQYLIIQNRTWENHCTYAGPFGMSRILLSQEKTKFFTRRLAGTFTWTLSDSSGVENPGGYCLTKWMILAAELKCFGNTAVAKCNVNHDAEFCDMLRLIDYNKAALSKFKEDVESALHLFKTTVNSLISDQLLMRNHLRDLMGVPYCNYSKFWYLEHAKTGETSVPKCWLVTNGSYLNETHFSDQIEQEADNMITEMLRKDYIKRQGSTPLALMDLLMFSTSAYLVSIFLHLVKIPTHRHIKGGSCPKPHRLTNKGICSCGAFKVPGVKTVWKRR
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm (PubMed:16731928).  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: FOM1_STRWE
Sequence: MQRPIVYVGMSADLIHPGHINILSRAAELGDITIGLLTDAAIASYKRLPHMTYEQRKAVVENLKGVASVVPQRTLDYAENLRTVRPDFVVHGDDWQTGVQRHTRERVIEVLSEWGGKLVEIPYTPGISSTRLHSSVKEVGTTPNVRLSRLRRLLDSKDIVRILEVHNGLTGLIIENSKVTVDNQAREFDGMWSSSLTDSLARGKPDTEAVDVSSRLQMVNELFEVTTKPLVFDGDTGGKPEHFGFTVRSLERLGVSAVIVEDKEGLKRNSLFGTDVPQTQSSVEDFSERIRIGKRAQITDDFMVIARIESLILEKGMADAVHRAEAYVDAGADGIMIHSRQSDPAEIFEFCRYFDKLPRRVPLVVVPTSYSSVRESELADAGVNMVIYANHLMRAVYPQVTKVVQSILQHGRAHEAESMLASIKDALSIIPENAG
What is the function of this protein?
Bifunctional enzyme that catalyzes two steps during fosfomycin biosynthesis (PubMed:28727444).  It catalyzes the conversion of phosphoenolpyruvate (PEP) to phosphonopyruvate (PnPy), the first step of the pathway.  It also catalyzes the cytidylylation of the 2-hydroxyethylphosphonate (HEP) intermediate to produce cytidylyl-2-hydroxyethylphosphonate (HEP-CMP), the fourth step of the pathway (PubMed:28727444).
What are the official names of this protein?
Fosfomycin biosynthesis bifunctional protein Fom1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the isocitrate lyase/PEP mutase superfamily. PEP mutase family.
Protein: OBGC1_ORYSI
Sequence: MAPAVAVVAAAAAFPFRLFSAEARRNTKGSRSKRGSARPLKPSPPPRPSASSSAAGGGGATTFTRLPLRNAPASVEVTLDRFPTANPEPRASTFTRRNGERLGDDEEDEEEEEDEVELGLRGATTFARLPLRDSPDGGDLTIGHFDAGVAPQEGLRSRAISRQLVEHLDDVEEEEEEQVVSRLDIFEGAKGREARAFLPDEDDEDDDVVVFDPEYDGYSDDEEFVATAVEQSPRGDAIAVAELEKLKYDNDDDDDDDDEVVVFHPDDDEEVDVFEDYDDDEEEETKEKGVPAVMRCFDTAKIYAKAGDGGNGVVAFRREKYVPLGGPSGGDGGRGGNVFVEVDGDMNSLLPFRKSVHFRAGRGAHGQGRQQAGAKGDDVVVKVPPGTVVRSAAGDVELLELMRPGQRALLLPGGRGGRGNAAFKSGTNKAPRIAEKGEKGPEMWIDLELKLVADVGIVGAPNAGKSTLLTAISAAKPTIANYPFTTLLPNLGVVSLDFDATMVVADLPGLLEGAHRGYGLGHEFLRHSERCSVLVHVVDGSGEQPEYEFEAVRLELELFSPSLVDKPYIVVYNKMDLPEASERWNKFQEKLQAEGIEPYCISAMNRQGTEDVVLAAYKVLQKDRQRMKDDEEWNGPENLNHVADAIKRERRAPMNEFEIFHDKGTNTWNVVGAGIERFVQMTNWQYSESLKRFQHALEACGVNKTLIKRGVKEGDTVVVGEMEMVWTDEPSKTRSSKTMNSKDDSVRWPEFG
What is the function of this protein?
Probable GTP-binding protein that may play a role in chloroplast development.
What are the official names of this protein?
Probable GTP-binding protein OBGC1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SYDND_GLOC7
Sequence: MRTHYCGDLRASDIDKTVTLFGWVDRYRDHGGVIFADLRDRTGRVQIVSDPQRTPESYQAAANLRNEYVIKVEGRVSKRPKESLNPKIPTGEVEIYADSIEILNGVNKQLPFVISSEDAELVREEVRLKYRYLDLRRDRMRKNLQLRHQVVQAMRRYLEDQQNFMEVETPILTRSTPEGARDYLVPSRTNPGKWYALPQSPQLFKQLLMVSGVDRYYQIARCFRDEDNRADRQPEFTQLDMEMSFMSFDEILDLNEGLIAHVFKTVKNIDIPRPFPRLTYAEAMEKYGIDRPDTRFGLELVDVSEIVKDSGFKVFSGAVKSGGIVKVLPIPEATNIISNVQIKPGGELFKEATEAGAKGIAYIRIKDNNELDTIAAIKDNLTDEQKQELIEKTGAKPGHLLLFGAGDTDTVNKSLARLRLVVGEKLGLIDEDKINLLWVTDFPMFEWNAEEKRLEALHHPFTAPKPEDINDLPHARALAYDMIFNGIELGGGSLRIYQRDIQEKVFSTIGLSMEEAYNKFGFLLEAFEYGTPPHGGIAYGLDRFVMLLAKEESIRDVIAFPKTQQASCLLTEAPSTVEPKQLKELHIASTFKPKS
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y556_LACDB
Sequence: MHEKYKKQLLILTGMSGAGKTVAAHSLEDVGYFVVDNLPPELLGNFWDLMNTSEDFEKVAVVIDLRVKSFYKDLIDEINSLEDSGQTQATIVFLEASDDTLVARYKETRRLPPLAENGRLLDGIRDERRILTPVRNRSNYILDTSKMTTKELKQKLQSKFGELHKPKFGIEVMSFGFKYGMPIDADIVMDVRFLPNPFYIPELRPFTGLDKRVFNYVMDKDETKVFYGKLLDLLLTAIPGYIDEGKEKLTIAIGCTGGQHRSVSIAQQLARDLSEKYPVDITHREISRYLRK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein LBUL_0556.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ISL1_MOUSE
Sequence: MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA
What is the function of this protein?
DNA-binding transcriptional activator (PubMed:14664703, PubMed:24643061, PubMed:25775587, PubMed:22343712, PubMed:18539116).  Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes (PubMed:24643061, PubMed:25775587, PubMed:18539116).  Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:25775587).  Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina (PubMed:24643061, PubMed:25775587).  Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (PubMed:18583962).  Binds to insulin gene enhancer sequences (By similarity).  Essential for heart development.  Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart.  Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (PubMed:14667410).
What are the official names of this protein?
Insulin gene enhancer protein ISL-1, Islet-1.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
Protein: SEG1_YEAST
Sequence: MFRRRTTAPEMEQADPTAVAAAASIGKLLMKKGNQSDNEQRPTYRSASMTNLRKPSAPKRMSSISSISSESRRSDGKGRPGKINSLTQRSSMGKGDSLNSPLTKEPQHKTRSHNRTSSLPNQRGQQSRNSSGLQRQKSKTHQRISYDEAQRTFKDFGGPQARGILTGQHRTENPSGSIPLRTTRKYIPGPNGLVAIEVPVEKPSNANTSKLLRRSNSAHSALNARNGSLLRKKVSQESLHSQPKKTSSLGNTSSTQAKKGQKAVQERNLAKKHPINSNVPLIETQVREETDQELKLDNSNSSESETVVNSENNLEKPSSLNIEKDDLSKLIHENIELESFIEEKGKEKPLNSDQEDVFISEKTVKGDVQWPKNNRQASTLEKTFNYDNEEKREGNKPVAEHPLPEAEVDDKSVEQLNNISSSGSYSAQGSVENSKPENGNKNLENDTTSSPTQDLDEKSRSIEEKDTLEGTESSKKVEKPDNCCEKISGANTSSKKGNVGDTKDEFFDTVEESDQKTSKSNSSKNTDHSNQTEPTPSLAQYLRTSNTYLSRKNQSKQAEQEKFHKPEAPMVPVTKVVTPIKSALKKSSGSSNHDSSMYSDNSPANGAYLSLTTAENTRLNAQMTMSDSVSRRASLKRSSIKRPQSVGQFRSIRSNSPSPPEKINNKRHSAIPLGTPEKGKPKRNSVMASLSKNSQQIQEPASVYESNGPNKPKNQINKNIKRGSQIAQNNKPSTKDMNSILYPKEPPPRKSSFEKTRSNESHLGFKKLSLRNGNFEEALSESYNGQASQNSTNVNRTDTAQEFFKYLGHSSRFADSDSEDESQFFNQGPSKYNTETEGNKTSGNKNSNGGNGAFSLFKSKSKQKENNVVSPGVSSPNHTTTDPAITSKKVDKKFSGLSLRAASEAEPAKNSNPSMTNRLRFSSNPENGESRLPQAQEVSVTKEKKGSFGKKLKKIFGRKK
What is the function of this protein?
Important for the biogenesis of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations.  Required for efficient incorporation of the eisosome component PIL1 into eisosomes.
What are the official names of this protein?
Eisosome protein SEG1, Stability of eisosomes guaranteed protein 1.
What is the protein family that this protein belongs to?
Belongs to the SEG1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to eisosomes.