PharMolix/UniProtQA huggingface dataset:
Protein: 4CL2_ARATH
Sequence: MTTQDVIVNDQNDQKQCSNDVIFRSRLPDIYIPNHLPLHDYIFENISEFAAKPCLINGPTGEVYTYADVHVTSRKLAAGLHNLGVKQHDVVMILLPNSPEVVLTFLAASFIGAITTSANPFFTPAEISKQAKASAAKLIVTQSRYVDKIKNLQNDGVLIVTTDSDAIPENCLRFSELTQSEEPRVDSIPEKISPEDVVALPFSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFNRDDVILCVLPMFHIYALNSIMLCSLRVGATILIMPKFEITLLLEQIQRCKVTVAMVVPPIVLAIAKSPETEKYDLSSVRMVKSGAAPLGKELEDAISAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKILDPDTGDSLPRNKPGEICIRGNQIMKGYLNDPLATASTIDKDGWLHTGDVGFIDDDDELFIVDRLKELIKYKGFQVAPAELESLLIGHPEINDVAVVAMKEEDAGEVPVAFVVRSKDSNISEDEIKQFVSKQVVFYKRINKVFFTDSIPKAPSGKILRKDLRARLANGLMN
What is the function of this protein?
Produces CoA thioesters of a variety of hydroxy- and methoxy-substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics (PubMed:10417722).  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioesters (By similarity).
What are the official names of this protein?
4-coumarate--CoA ligase 2, 4CL 2, 4-coumarate--CoA ligase isoform 2, At4CL2, 4-coumaroyl-CoA synthase 2, Caffeate--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: PDXH_NOCSJ
Sequence: MGHLDLAALREEYARAGLDEADLAPDPIAMFDRWMGEAHDAIRHDANAMVLSTVGPDLAPSSRMLLLKGVAEDGFVFFTNTASLKGHELAANPRCSLLFPWHPLERQVRVDGVAAPLPRADVEAYFASRPRASQLGAWASHQSEVVSGRAELEAAYAAAEVRYPDQVPTPEEWGGYVVRPEVVEFWQGRTGRLHDRLRYRRTPGGWVTERLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: HMGB5_ARATH
Sequence: MKDNQTEVESRSTDDRLKVRGNKVGKKTKDPNRPKKPPSPFFVFLDDFRKEFNLANPDNKSVGNVGRAAGKKWKTMTEEERAPFVAKSQSKKTEYAVTMQQYNMELANGNKTTGDDEKQEKAADD
What is the function of this protein?
Binds preferentially double-stranded DNA.  Confers resistance to salt and drought stresses.
What are the official names of this protein?
High mobility group B protein 5, High mobility group protein D, AtHMGdelta, HMG delta, Nucleosome/chromatin assembly factor group D 05, Nucleosome/chromatin assembly factor group D 5.
What is the protein family that this protein belongs to?
Belongs to the HMGB family.
Protein: OXYT_STRRM
Sequence: MTTTPLAPVAQARSLLQLTTAYHQAKALHSAVELGLFDLLADGPATAEEVKDRLRIVHPLAKEFLDALVALELLEADGDRYRNSPAAQAFLVSGASEYLGGTVLQHARKHYHVWAGLTTALQEGEAGSGAEAHGPEAYPKHYEDPERARQVMAHFDTFSSFTAEELARRVDWSGYGSFIDIGGARGNLATRVALAHPHLHGAVFDLPALAPLAGELIRERGLEGRVRFHGGDFLTDPLPSADAVVTGHVLPDWPVPQRRKLLARIHEALPSGGALVVYDLMTDPATTTVHDVLQRLNHGLIRGDSSSSSVEEYRAEIEEAGFRVRQAERIDNLLGDWLIVAVKP
What is the function of this protein?
Involved in the biosynthesis of the tetracycline antibiotic, oxytetracycline.  Catalyzes the dimethylation of 4-amino-4-de(dimethylamino)anhydrotetracycline (4-amino-ATC) to yield anhydrotetracycline (ATC) (PubMed:1134373, PubMed:18422316).  Also able to catalyze the dimethylation of 7-chloro-, 6-demethyl-, 2-decarboxamido-2-nitrile-, and 4-methylamino-derivatives of 4-amino-4-de(dimethylamino)anhydrotetracycline (PubMed:1134373).
What are the official names of this protein?
N,N-dimethyltransferase OxyT, 4-amino-anhydrotetracycline N(4)-methyltransferase, S-adenosylmethionine: dedimethylamino-4-aminoanhydrotetracycline N-methyltransferase, SAM-dependent methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: BH011_ARATH
Sequence: MDQPMKPKTCSESDFADDSSASSSSSSGQNLRGAEMVVEVKKEAVCSQKAEREKLRRDKLKEQFLELGNALDPNRPKSDKASVLTDTIQMLKDVMNQVDRLKAEYETLSQESRELIQEKSELREEKATLKSDIEILNAQYQHRIKTMVPWVPHYSYHIPFVAITQGQSSFIPYSASVNPLTEQQASVQQHSSSSADASMKQDSKIKPLDLDLMMNSNHSGQGNDQKDDVRLKLELKIHASSLAQQDVSGKEKKVSLTTTASSSNSYSLSQAVQDSSPGTVNDMLKP
What are the official names of this protein?
Transcription factor bHLH11, Basic helix-loop-helix protein 11, AtbHLH11, bHLH 11, Transcription factor EN 137, bHLH transcription factor bHLH011.
What are the subcellular locations of this protein?
Nucleus.
Protein: GSA_DESVV
Sequence: MSQRSSELFERAQQLIPGGVNSPVRACLGVDSEPLFIARAAGSRLHTVDGETFIDFVESWGPMLLGHTHPEVTAAVHAAVDRGTSYGAPCEDEVVLAAKVVDALPGVDMVRMVNSGTEATMSALRLARGYTGRTKLVKFVGCYHGHADPFLASAGSGVATLSIPGTPGVPESTVRDTLLAPYNDLAAVKDLFALHGKDIAAIIVEAVAGNMGLVPPKAGFLEGLRELCDQHGALLIFDEVITGFRVSFGGAQQRFGITPDLTTLGKIIGGGLPVGAYGGKREIMQRIAPCGEVYQAGTLSGNPLAMAAGIATLDVLSRSDYAGLEARVSAFVKELEAILKGKGVPVRINTLASMFTVFFTNDPVTDFASAKTADGALYTSFYKQMRAQGIYLAPSPFEAAMVSFAHTDDDLAAMLDAARKVTF
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INS_ACIGU
Sequence: AANQHLCGSHLVEALYLVCGERGFFYTPNKVGIVEQCCHSPCSLYDLENYCN
What is the function of this protein?
Insulin decreases blood glucose concentration.  It increases cell permeability to monosaccharides, amino acids and fatty acids.  It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
What are the official names of this protein?
Insulin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLK_BURO1
Sequence: MSTGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTITDAIRKYLKDVKISRVNHAAIAIANPVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQVGGGARRQNSVIGLLGPGTGLGVSGLIPADDRWIALGSEGGHASFAPQDEREDLVLQYARKKFPHVSFERVCAGPGMEIIYRALAARDKKRVAATVDTVEIVERAHAGDALALETVECFCGILGAFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKGRFTHYLENIPTYLITAEYPAFLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRASTNGELPEAVAQAKARASDDETADVLDWLSHGASPAAKDVARD
What are the official names of this protein?
Bifunctional protein glk.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the bacterial glucokinase family.
Protein: JUPIT_DROAN
Sequence: MAAYAAFKHVELYNVGKAKKRVLRAPGGGSSDIFGSEMPQTPRGHVKNRMASNIFAAEKDNGVKNNVRQGAHRFYFIGDAPRRGQKTVDSHNRLFGEPTRPITPAKNHMKSSIPFGGQNTEAAAAQKLLTTNGHYNGKSGSVSSASSSVSSSTENLKMNSGSRGVFRNMSTAPGSKSNPIPSVRDPACPLTPEPSIPEIPPPDVLPIDIPCKEIEVGDIPADNYTYNQSDKRDEAIQSRCDSGTNPEKPYSLNHMEGPADLQEPMHPCPDTLKEAAQQCKMDSRNPITGLGLNGDGVGGLKPKKQKNREGNPVTGEGYKPGANDFHQRADSSQGGTPIINKNRVPPGGYSSGLW
What is the function of this protein?
Binds to all microtubule populations.
What are the official names of this protein?
Microtubule-associated protein Jupiter.
What is the protein family that this protein belongs to?
Belongs to the MAP Jupiter family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
Protein: Y3225_DICDI
Sequence: MGHHHHYAYTTTTPYIMPGVPPPVVYGAPPPMMVVPPPMGIVQPQVFVQGMVPPPVVYGAPPPMMGVPPPMGQPFYPPSYY
What are the official names of this protein?
Uncharacterized protein DDB_G0276477.
Protein: SCNNB_BOVIN
Sequence: MHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMWFVLTLLFTSLVCWQWGLFIKTYLNWEVSVSLSIGFKTMDFPAVTICNASPFQYSKVQHLLKDLDELMEAVLGRILGPELSQVNDTRALNLSIWHHTPLVFINEQNPHHPVVLDLFEDNFNGSASNSPAPGRPCSAHRCKVAMRLCSHNGTTCTFRNFSSATQAVTEWYTLQATNIFAQVPNQELVAMGYPAERLILACLFGAEPCNYRNFTPIFHPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDMGQEDYVPFLTSTAGARLMLHEQRSYPFIKEEGIYAMAGMETSIGVLVDKLQRKGEPYSQCTKNGSDVPIQNLYSNYNTTYSIQACIRSCFQEHMIRECGCGHYLYPLPHKRKYCNNQEFPDWAHCYSALRISLAQRETCIYACKESCNDTQYKMTISMAVWPSEASEDWIFHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVALAKSVRQKRAQARYEGPPPTVAELVEAHTNFGFQPDLATPGPDVEAYPHEQNPPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
What is the function of this protein?
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride.  Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells.  Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.  Controls the reabsorption of sodium in kidney, colon, lung and sweat glands.  Also plays a role in taste perception.
What are the official names of this protein?
Amiloride-sensitive sodium channel subunit beta, Beta-NaCH, Epithelial Na(+) channel subunit beta, Beta-ENaC, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB.
What is the protein family that this protein belongs to?
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=Apical membrane of epithelial cells.
Protein: RPPH_PSYA2
Sequence: MIDADGFRANVGIILANTQGQVLWAKRIGHNAWQFPQGGIDRGETPMDAMYRELWEEVGLHPRHVDLLAVTQDWLRYRLPKRYVRHGQYPLCIGQKQKWFLLRLDEPNTQHIRFDEGKAEFDNWQWVSYWYPLGQVIHFKRGVYRRALQELVPELPLQQGLIIPEQNNHLLQF
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: APR_MOUSE
Sequence: MPGRKARRNAPVNPTRAELPPEFAAQLRKIGDKVYCTWSAPDITVVLAQMPGKSQKSRMRSPSPTRVPADLKDECAQLRRIGDKVNLRQKLLNLISKLFNLVT
What is the function of this protein?
Promotes activation of caspases and apoptosis.  Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria.  Contributes to p53/TP53-dependent apoptosis after radiation exposure.  Promotes proteasomal degradation of MCL1.  Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity).  Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1.
What are the official names of this protein?
Phorbol-12-myristate-13-acetate-induced protein 1, Protein Noxa.
What is the protein family that this protein belongs to?
Belongs to the PMAIP1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RPPH_XYLF2
Sequence: MIDPDGYRPNVGIVLIRRDGQVFWGRRVRRDGWQFPQGGMHSDETPVEAMYRELNEETGLLPEHVQLVGATPGWLRYRLPSQAVRCNRSQMCIGQKQVWFLLQLIGDESHVQLDQSENPEFDHWRWVSFWYPIEHVVMFKRSVYARALCQLASLAQQVVGLEVGTMPQYVQDICLLNVGYKHLPNWVSRY
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RL20_XYLF2
Sequence: MARVKRGVQARRRHKKILSLAKGYYNARRKVFRVAKQAVIKAQQYAYIGRKQKKRNFRSLWIVRINAAARMNGLSYSRFMNGILKCGITLDRKMLADIAVHDPAGFTALAEKAKTMLAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: MTMC1_METAC
Sequence: MANQEIFDKLTNAIATQNVAGCAQLAQEALDAGISPLDIITKGLSPGMKIIGDKFEAAEVFLPQIMMSAKAMEAAMKVLTPELEKTKVEGEEGTGLAITFVAEGDIHDIGHRLVTTMLGANGFDILDLGTDVLNETVVEEAAKHKGEKVLLVGSALMTTSMLGQKDLMDRLREENLRDSVKCMFGGAPVSSKWIDEIGADATAENAAEAAKVALNIMK
What is the function of this protein?
Acts as a methyl group carrier between MtmB and MtbA.
What are the official names of this protein?
Monomethylamine corrinoid protein 1, MMCP 1.
What is the protein family that this protein belongs to?
Belongs to the methylamine corrinoid protein family.
Protein: GRSA_ANEMI
Sequence: MLNSSKSILIHAQNKNGTHEEEQYLFAVNNTKAEYPRDKTIHQLFEEQVSKRPNNVAIVCENEQLTYHELNVKANQLARIFIEKGIGKDTLVGIMMEKSIDLFIGILAVLKAGGAYVPIDIEYPKERIQYILDDSQARMLLTQKHLVHLIHNIQFNGQVEIFEEDTIKIREGTNLHVPSKSTDLAYVIYTSGTTGNPKGTMLEHKGISNLKVFFENSLNVTEKDRIGQFASISFDASVWEMFMALLTGASLYIILKDTINDFVKFEQYINQKEITVITLPPTYVVHLDPERILSIQTLITAGSATSPSLVNKWKEKVTYINAYGPTETTICATTWVATKETIGHSVPIGAPIQNTQIYIVDENLQLKSVGEAGELCIGGEGLARGYWKRPELTSQKFVDNPFVPGEKLYKTGDQARWLSDGNIEYLGRIDNQVKIRGHRVELEEVESILLKHMYISETAVSVHKDHQEQPYLCAYFVSEKHIPLEQLRQFSSEELPTYMIPSYFIQLDKMPLTSNGKIDRKQLPEPDLTFGMRVDYEAPRNEIEETLVTIWQDVLGIEKIGIKDNFYALGGDSIKAIQVAARLHSYQLKLETKDLLKYPTIDQLVHYIKDSKRRSEQGIVEGEIGLTPIQHWFFEQQFTNMHHWNQSYMLYRPNGFDKEILLRVFNKIVEHHDALRMIYKHHNGKIVQINRGLEGTLFDFYTFDLTANDNEQQVICEESARLQNSINLEVGPLVKIALFHTQNGDHLFMAIHHLVVDGISWRILFEDLATAYEQAMHQQTIALPEKTDSFKDWSIELEKYANSELFLEEAEYWHHLNYYTENVQIKKDYVTMNNKQKNIRYVGMELTIEETEKLLKNVNKAYRTEINDILLTALGFALKEWADIDKIVINLEGHGREEILEQMNIARTVGWFTSQYPVVLDMQKSDDLSYQIKLMKENLRRIPNKGIGYEIFKYLTTEYLRPVLPFTLKPEINFNYLGQFDTDVKTELFTRSPYSMGNSLGPDGKNNLSPEGESYFVLNINGFIEEGKLHITFSYNEQQYKEDTIQQLSRSYKQHLLAIIEHCVQKEDTELTPSDFSFKELELEEMDDIFDLLADSLT
What is the function of this protein?
In the first step of peptide synthesis this enzyme activates phenylalanine and racemizes it to the D-isomer.
What are the official names of this protein?
Gramicidin S synthase 1, Gramicidin S synthase I.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: SSRP_ZYMMO
Sequence: MAAFRPPQFKKSKILAENRRARYEYAFEDFYEAGLALTGTEVKSLRFGQGSIAESYAEVKNGEVTLINANIPEFSHGNRFNHEPKRPRKLLLHEREIRKMQTAVSREGMTVIPVSLYFNNKGKAKLELAIARGKKTHDKRATIKERDWKRDQARLLRDKG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: RL7_XANAC
Sequence: MSLTNEQIVDAIAEKSLMEVMELVKAIEEKFGVSAAAPVAAAAAGPAAVVEEQTEFNVVLTNCGTNKVGVIKAVRAVTGLGLKEAKDLTEAGGMLKEGASKDEAEKIKKELTEAGATVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: DNLJ_PARXL
Sequence: MARTPVSPPATSAPAERAAWLRAELERANYAYYVLDQPDLPDAEYDRLFKELESIETEHPDLIVPDSPTQRVGGEAASGFEPVVHEQPMLSLNNGFADEDIVAFDKRVGDALGKNASEPPVPVEYAAELKFDGLAISLRYVDGVFVQASTRGDGTTGENVTENVRTIRSIPLRLKGKRVPHVLDVRGEVLMFKRDFERLNERQRAAEQKEFANPRNAAAGSLRQLDSKITAQRPLSFFSYGIGVLEGMDMPATHSELLDWYKELGLPVNGERAVVHGAEGLLGFFHAVGEKREKLPYDIDGVVYKVNRRDEQEALGFVSRAPRFALAHKFPAQEALTRLVAIDVQVGRTGAVTPVARLEPVFVGGATVTNATLHNEDEVRRKDIRIGDTVIVRRAGDVIPEVVSALLDRRPDDAREFVMPTHCPVCGSNIERLPDEAIARCTGGLFCPAQRKQALWHFAQRRALDIDGLGEKIIDQLVEQNLVRTPADLFNLGFATLAELDRFAEKSAQNLLDSLEKAKHTTLARFIYALGIRHVGESTAKDLAKHFGSLDPIMDASVEALLEVNDVGPVVAESIHQFFAEEHNRTVIEQLRAPGRVTWPEGPPAPKAPQGVLAGKTVVLTGTLPSLAREEAKEMLEAAGAKVAGSVSKKTDYVVAGAEAGSKLAKAEELGIPVLDEDGMRKLLEGQL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: XYLA_ECO81
Sequence: MQAYFDQLDRVRYEGSKSSNPLAFRHYNPDELVLGKRMEEHLRFAACYWHTFCWNGADMFGVGAFNRPWQQPGEALALAKRKADVAFEFFHKLHVPFYCFHDVDVSPEGASLKEYINNFAQMVDVLAGKQEESGVKLLWGTANCFTNPRYGAGAATNPDPEVFSWAATQVVTAMEATHKLGGENYVLWGGREGYETLLNTDLRQEREQLGRFMQMVVEHKHKIGFQGTLLIEPKPQEPTKHQYDYDAATVYGFLKQFGLEKEIKLNIEANHATLAGHSFHHEIATAIALGLFGSVDANRGDAQLGWDTDQFPNSVEENALVMYEILKAGGFTTGGLNFDAKVRRQSTDKYDLFYGHIGAMDTMALALKIAARMIEDGELDKRIAQRYSGWNSELGQQILKGQMSLADLAKYAQEHNLSPVHQSGRQEQLENLVNHYLFDK
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODO1_XENLA
Sequence: MFNLRTCASKLRPLTASQTIRSLKHNRPAAPRTFQQFRCLSTPVAAEPFLSGTNSNYVEEMYYAWLENPKSVHKSWDIFFRNANAGASPGAAYQSPPSLGSSLSTLTQAQSLLHSQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSCVPADIVTSSDKLGFYGLQESDLDKVFHLPTTTFIGGNEMALPLREIIRRLENAYCQHIGVEFMFINDLEQCQWIRQKFEAPGIMQFNNEEKRTLLARLVRSTRFEEFLHRKWSSEKRFGLEGCEVLIPALKTIIDKSSGNGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEATDEGSGDVKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVQGKTKAEQFYCGDTEGKKVMAILLHGDAAFAGQGIVYETFHLSDLPSHTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVMYVCNVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKAVLQKYAETLISQGVVNQLEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPRSMTCPSTGLTEEDLTHIGNVASSVPVEDFMIHGGLSRILKGRGEMVKNRTVDWALAEYMALGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFVCPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVWPKASEDFAVGQLYDCNWIVVNCSTPANFFHVIRRQILLPFRKPLIVFTPKSLLRHPEARSSFDDMLPSTHFQRIIPEAGPASQNPEGVKRLIFCTGKVYYELTKERSGRDMEGDVAIARVEQLSPFPFDLVEKEVQKYPNADLVWCQEEHKNQGYYDYVKPRLRTTIHRTKPVWYAGRDPAAAPATGNKKTHLTELRRFLDTAFNLDAFKGHF
What is the function of this protein?
2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC).  Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC.  Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST).  Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids.  Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate.  Mainly active in the mitochondrion.  A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
What are the official names of this protein?
2-oxoglutarate dehydrogenase complex component E1, E1o, OGDC-E1, OGDH-E1, 2-oxoglutarate dehydrogenase, mitochondrial, Alpha-ketoglutarate dehydrogenase, Alpha-KGDH-E1, Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion. Nucleus. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2- oxoglutarate dehydrogenase complex is required for histone succinylation.
Protein: HTPG_MYCBO
Sequence: MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVDTSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASEELIGQFGIGFYSSFMVADKVQLLTRKAGESAATRWESSGEGTYTIESVEDAPQGTSVTLHLKPEDAEDDLHDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIETETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFEYQALLFIPSHAPFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKGVVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLKEGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVDEVWVGMVPEFDGKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKEVRLSTRLTESPACLITDAFGMTPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQDRADDAEKSLAETAELLYGTALLAEGGALEDPARFAELLAERLARTL
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPC3_LODEL
Sequence: MDEDYYSAVRAQSPKTYLYALTAETHLGEVASVIITTLLASGRLNIKQISVKTKLAIKSIKSAIVSLIQLNCLYYWQDDKNPTIFYYSVNETGLKTLVYSGDILNHITQEYGDEEAEIIQNIIMNGHLKLDDYLRQYDNDLEKSDEASLRLEKEKIFLKLYNEGWIKILSLNDFHHINDIWEKLFDDTLRNTPRSSTTSEVKRLAEAQSVCKEKLMALLEKTKQPLDLYITENGYKKLNPNLVLTFNLTRFQKRSRTVALTNLAKSRIGLITSKVYEAALKSVENGSPDLSHPFLEIPGLINNPTDVKDFKDSLETTLTAEKKIVFTVKDVMRYFPKLLDIKNSVITENSKRSFNDINANPETSNKKIKLENGNAFNTGGGASGANTSNSNNHLTASSFFTDEDRMSIIEQHLRLLAAGTNTQFVHEISPGRYAIPFVKLSNELKQFHYESLVKSTLQDQAFRVLRCIKHLKLADEKSIANAVLLKEKTVRNEVYQLIKANVVEIQEIPRSVDRAASKTFYLVKYKEYHRFESLINCLVYNMAEIVRNIQNFKMENKILLDKCNRVDVEGNEDEMLLDSELKTLHGLQNREVMNLVRFNRTRSLWDIFTL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC3, RNA polymerase III subunit C3.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LCMT1_EMENI
Sequence: MSAPQIPNLNTLRRGGGRGRFRARGGPDSSSSSGNKDRVVQGTDNDASVSRLSAVELGYLEDPFARALTPMGQEMRRLPIINRGTYVRTTAIDQLVASFLGLKADSDPTWKLKKKQIISLGAGSDTRVFRLLSLRPALDIIYHEIDFAVNNTAKIKAIQGTPLLQRVLGQSQVSISNEGDELHSPAYHIHAVDLRTLAQKGEGDKSTGQDPGRRLQDFVDTTLPTLLLSECCLIYLSPNDAAGVVRYFTHTLFPASQETETLALVLYEPIRPDDAFGRTMVANLATRGIQLQTLHQYASLGAQRQRLREHGFNGGQAAADVDFLWERWVAEEEKERVAALEMLDEVEEWKLLAQHYCVAWGWRKGSTRFTGWGDLDGQSAEE
What is the function of this protein?
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
What are the official names of this protein?
Leucine carboxyl methyltransferase 1, Protein phosphatase methyltransferase 1, [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LCMT family.