PharMolix/UniProtQA huggingface dataset:
Protein: GATB_LACCB
Sequence: MNFETTIGLEVHVELKTKSKMFSPSPVTYGQEPNTQTNVIDWGFPGVLPSINRGAYQLGIMVGLALHADITRLTHFDRKNYFYPDNPKAYQITQSEKPLGTNGWVEIEVDGKKKKIGIAELHVEEDAGKNQHEDDGYSYVDLNRQGTPLVEIVSKPDITSPEEAYAYLETLRQIVQFTGASDVKMEEGSMRVDTNLSVRPIGQEHFGTKTEIKNLNSFVHVRDGLAFEEKRQQAVLLSGGEVRQETRRWDPDAKETLLMRVKEGADDYRYFPEPDLPPVAVSQKWIDDIQASLPQPPAERRQRYIEDWGIPAYDAGVLTQTKEMSDFFEATVAQGADAKQASNWLMGEVSGFLNAQHVELGQVALTPAHLAGMIKLIGDGTISSKMAKKVFKEIIQHDTDPDKWVHEKGLIQLSDPAKLTPIIDEILDNNQQSIDDFKAGKDRAIGFLVGQIMKQTHGQANPKVVNQILMAEIKQR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: Y095_MYCPN
Sequence: MNQQLNTTRKSTAARGRMGLVGGILLVIGTCIGAGIFFKSERVLQNMGGNTTLALLVWLMAGITVILMGLALVEITAKAAFDDLALLSWTQKFTNNTFYKACKRFLIWIYLPTTFFFMPLYLVQSLQDGLRGFGVANHFNTPHDWAIWMVIVLLINLWFFFTSGLSVKWTSVQNVVLLLLKVIPLIAVVILALWLGASAEQMERQPVVPVKDFTAISPFFGWFSAMGAIFFAFDGFYVSAAAKTQLKKQKNYRK
What are the official names of this protein?
Uncharacterized protein MPN_095.
What is the protein family that this protein belongs to?
To M.pneumoniae MPN_308 N-terminal region.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL10_GEOKA
Sequence: MSSAIELKKQVVAEIADKFRASKATVIVDYRGLNVAEMTELRKQLREAGVEFKVYKNTLTRRALAEVGLEGLDEVFTGPNAIAFSNEDVVAPAKILSEFAKTHEALEIKGGVIEGNIASKEEIDALAKLPSREGLLSMLLSVLQAPIRNFALAIKAVADKQEEQGA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: PNM8C_HUMAN
Sequence: MLFGVKDIALLEHGCKALEVDSYKSLMILGIPEDCNHEEFEEIIRLPLKPLGKFEVAGKAYLEEDKSKAAIIQLTEDINYAVVPREIKGKGGVWRVVYMPRKQDIEFLTKLNLFLQSEGRTVEDMARVLRQELCPPATGPRELPARKCSVPGLGEKPEAGATVQMDVVPPLDSSEKESKAGVGKRGKRKNKKNRRRHHASDKKL
What are the official names of this protein?
Paraneoplastic antigen-like protein 8C.
What is the protein family that this protein belongs to?
Belongs to the PNMA family.
Protein: DNAA_BACSU
Sequence: MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTITAPNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKEDTSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQFLAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMYLSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.  DnaA can inhibit its own gene expression as well as that of other genes.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE7_HPV50
Sequence: MRGDKPTIPDIVLEELVLPVNLLSDESIETDDIAESERSPFKIDSTCKHCHCRVRLCCVATDAAIRVFECLLQSEFSFLCLKCSKELLRNGRT
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: GCH1_PERMH
Sequence: MSIDREKLKRSIRLFLEAIGEDPDREGLKETPDRIVRLWEEFKSYENFNMTVFEDIGDYNEMVVVRDIQFYSFCEHHLLPFFGKAHIAYIPEKKVCGLSKLVRVVNKFAYRPQVQERLTAQIAEFLEKELSPKGVAVVLEAEHLCMSMRGVKNPTSYTITSKLTGAFMEDEKTRNEFLNLIHNGR
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: MSD7_HUMAN
Sequence: MASANSSAGIRWSRQETRTLLSILGEAEYIQRLQTVHHNADVYQAVSKRMQQEGFRRTERQCRSKFKVLKALYLKAYVAHATSMGEPPHCPFYDTLDQLLRNQIVTDPDNLMEDAAWAKHCDQNLVASDAPGEEGTGILKSKRTQAADHQPILKTVKASDEDCQLRISDRIRETSDLEDSWDESSGAGCSQGTPSYSSSHSLFRGAVAPCQSSPMARLGVSGEPSPCTSTNRSTPGVASTPQTPVSSSRAGFVSGGDRPLTSEPPPRWARRRRRSVARTIAAELAENRRLARELSKREEEKLDRLIAIGEEASAQQDTANELRRDAVIAVRRLATAVEEATGAFQLGLEKLLQRLISNTKS
What are the official names of this protein?
Myb/SANT-like DNA-binding domain-containing protein 7.
Protein: CU36A_MANSE
Sequence: MKLFVLAAVLGVCLADRLDNKYLPPRGNAGAGFGPGFGGAGPKGGGSGFGGAGSGFGGAGSGFGGAGSGFGGGAGGGFGHGGAGSGFGGQAGGYSGAGGAGGYIGGASGQYSGRGGAASADANAQILRLNNEVTAEGFAYDFETSNGIRADAQGVATNGVQSQGSFAYKGDDGQDYSITYTADENGFVSQGAHLPTPPPIPEEILKSLEQNARDEAAGIVDDGTYRGEGAGAGGAGGYSGAGGCSGGAGGAGGFGAGGAGRAGGTATSASEAPTTTIRLM
What are the official names of this protein?
Pupal cuticle protein 36a, CP36a.
Protein: ATG2_ASHGO
Sequence: MSSWLPQNVQKRLLIYLLQQISIFSQIDTTNLDVSLGCRSQFAFHDVELNVDHMRVPHITVESGHISELELGLVVSGGLDITGDGLCFVVRPELSEVAGSHDLAQSLARSIMDLTNSMMQPLPEVLEGDEVLANSCSEAGDAQQPASSSALDKMRNKVLERALSNLTVRIINVRIQVLFPGQQSITVLVGSVELSTVDKTRRVDLQDICISHSELVPSPEQPDEFMSTSASNSIYMSAIDSLPFGSRSKMEENARNVRALLQMDKLHVTFQGISSVEDISIRDLMLHMGRVDVFLDAIIAVDIGVFEVLVQFVAEFQQDTEVSETSNTLQNYKRFRQEQNLEEDLQITGFTIEELRITLSQSVKVSVIDIQLRNRYIENSTVTVGRVTICDYDLDLLHIDAGSKPCLELTVDSRKLQRIISVDGDIHMDISSTFVSSLIPLIFRLQELGRGLHFVGTNNCKMSQEFKTQVETKTIILSLPVGDDTLQMIIQPISYELSLHTVFTDFISISKVQSSETRDIAIIREIKIGYQTANFQVKSYNLKLSETLLTSKLRGSVSSVELYCSDSDIKWLFDGLSPYQDMITPYMHSKPEVRKPIMNKSVRILSASSVIHRQNVFSDMVLLIERITCSLSADSISSFGNVKTELNSSLLSLNTDNSIIFHSSCVKGSTVFSDVKYCLFEPIKTKDVTKPALFVQRFENGKLKVNVQNTCIYYHAKWLDILDESKGTKSTPQQESAVPVPLQQRIEVKFHDCALSMHPYRLKSALLICVNRCILDISVPPANFKCIIRSPTFMLADDCSNMKTSITESWESLVRYYSKAGFAVIGKSGLLSCTIKQSGGQICLDIDVDRIDLSICADSFQCLIQTLIDIKPPVSFPDEKKYRTEPCSIPVFENVDDEFFVPKGTSNLPALNDMHIVDDFINNSNNSFSEVQVIEETEEGSPLKLEDNGLLFDEGHFNKEDIPVATDSKFFPFGPVAIVLHLFVRKASIKLHDGYDWVYTRRSISKVVDDLEDEVHKQDQPGRVETSLFDSIYLYATPDSNIKKAVSSNIQSEDIIAENYSSKMKLRPSKHHKILIELTNMKLTFSGYSYDEPTEDIADWSTDLLNSIDVEVKTFEIVDNVATSTWNKFLTELKEAHGGSPSMLALSISLVRPIDFLYATELIISAQVSPLRLHVDQDTLDFLIRFSEFKDARFDLIDDYPDIVYIQRFEVNSIDVKLDYKPKKVDYVGLKSGHTSELMNFFTLDGAKMTLKRVVLYGVDGLGELHNCLSSIWTPDITRSQLSGVLKGVTPLKSIITLGSGVKALVTVPLKEYRQDQRLTRSLQKGARDFLKTTSGELIRLGVRMASGTQAILENTEEFFGGQGARARCMSARLPEDELSPVPSACDEFDLFRSSIPRKQSPIVPIPSEEDDIEPLKAISLYADQPQNAQKGVKEAYGSLGKNLTIAYGAVRRAQRDARHSISAQDAATAFARATPIAFIRPMIGATEAVSKTLQGISNQMDRDQLVHMRDKYKQSSHYQRKRER
What is the function of this protein?
Lipid transfer protein required for autophagosome completion and peroxisome degradation.  Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion.  ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region.  The latter binding is assisted by an ATG18-PtdIns3P interaction.  ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
What are the official names of this protein?
Autophagy-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG2 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: INT6_HUMAN
Sequence: MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCMSPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
What is the function of this protein?
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.  The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable).  Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).  May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144).
What are the official names of this protein?
Integrator complex subunit 6, Int6, DBI-1, Protein DDX26, Protein deleted in cancer 1, DICE1.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL28_SACD2
Sequence: MAKVCQVTGKRPVTGHNVSHAKNHTKRRFLPNLHSHRFWVESEKRFVKLRISTKGMRIIDKKGIDTVLAELRARGEKV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: END4_YERPE
Sequence: MKFVGAHVSAAGGVDQAVIRAHELEATAFALFTKNQRQWRAAPLAEDVIEKFKLACEKYGYTSAQILPHDSYLINLGHPVTEALEKSREAFIDELVRCQQLGLSLLNFHPGSHLLQIDEDQCLARIAESINIALDATEGVTAVIENTAGQGSNLGFKFEHLAAIIERVEDKSRVGVCIDTCHAFAAGYDLRTEEDCEHTFAALGKIVGFQYLRGMHLNDAKSEFNSRVDRHHSLGEGNIGKTVFSYIMRDSRFDNIPLILETVNMDIWAEEIAWLKSQAEIEPSL
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: VP3_ROTHU
Sequence: MKVLALRHSVAQVYADTQTYVHDDSKDEYENAFLISNLTTHNILYLNYSVKTLKILNKSGIAAIEIQSPDELFTLIRCNFTYNYENNTVYLHDYSYYTNNEIRTDQHWVTKTDITNYLLPGWKLTYVGYNGKNTRGHYKFSFICQNAATDDDIIIEYIYSNELDFQTFLLRKIKERMTTSLPITRLSNRVFRDKLFSSILNTHKKVINVGPRNESMFTFLNLPTIKQFSNGAYLVKHTIKLKQERWLGKRVSQFDIGQYKNMLNVITTIYYYYNLHFSKPIIYMLGSAPSYWIYDIKQYSDFTFETWDPLDTPYSTTHHKELFFDKDINRLKDNSILYIDIRTDRGNMDWKEWRKVVEHQTISNLNIAYKYLSTGKAKVCCVKLTAMDLELPVTTKLLHHPTTEVRSEFYAILDVWDVNTIKRFVPKGVFYAFINNVITENVFIQPPFKLKTSSNDYIVALYALSNDFNSRQDVINLINQQKQSLITVRMNNTFRDEPKVNFKNIYDWTFLPTDFETKGSIITSYDGCLGIFGLSISLSSKPTGNNHLFIINGTDKYYKLDQYANHMGISRRSHQIRFSESATSYSGYIFRDLSNNNFNLIGTNVENSVSGHVYNALIYYRYNYAFDLKRWIYLHSIGKANVEGGRYYEHAPIELIYACRSAKEFAILQDDLTVLRYANEIERYINIVYNITYADDPNYFIGIEFTNIPYEYDVKVPHLTLGVLFISDNMINDVITVLKKMKPELFKMEISTSYTYMLSDNIYVANASGVLSTYFKLYNMFYRSHITFGQSRMFIPHITLSFSNRQMVRIESTRLKISSIYLRKIKGETVFDMSE
What is the function of this protein?
Counteracts the host innate immune response thanks to its phosphodiesterase that degrades the 5'-triphosphorylated, 2'-5' linked adenylate oligomers produced by the host cell IFN-inducible 2',5'-oligoadenylate synthetase (OAS).  The host RNaseL is therefore not activated.
What are the official names of this protein?
Protein VP3.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP3 family.
What are the subcellular locations of this protein?
Virion. Note=Attached inside the inner capsid as a minor component. There are about 11 to 12 copies per virion.
Protein: Y1359_HAEDU
Sequence: MQKIPSFISRFIQDNHVVNFAAYTIDDFWTASCFYAFDHNMARLILLTSKNTRHSQIMLHNPKIVGTISAQITDIQAIKGIQFSATSQLLTKQDTEYHSSLTHYYQRHPFARLTSSDVWLLHLDMIKYTSNEYLFAQKSIWQRHTE
What are the official names of this protein?
UPF0306 protein HD_1359.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: NAGZ_SALEP
Sequence: MGPVMLNVEGCELDAEEREILAHPLVGGLILFTRNYHDPEQLRELVRQIRAASRNHLVVAVDQEGGRVQRFREGFTRLPAAQSFFALHGLEEGGRLAQEAGWLMASEMIAMDIDISFAPVLDVGHISAAIGERSYHADPAKALAMATRFIDGMHDAGMKTTGKHFPGHGAVTADSHKETPCDPRPETDIRGKDMSVFRTLISENKLDAIMPAHVIYRAIDPRPASGSPYWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERAQASLDAGCDMILVCNNRKGAVSVLDNLSPIKAERVTRLYHKGSFSRRELMDSARWKTASAQLNQLHERWQEEKAGH
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGGPS_METAR
Sequence: MAPIDWKKWRHVTKLDPDKKITRQDIAAIVDSGTDAVMISGTQNITKENVGNMIDMLAEYSIPKVLEPSVSAIIRNDVDFIFVPSIFNTKYSKFAVGYHKDFVKNYPDEVLDKVIPEAYIVLNPLSAVAIVTRAQTGISPREAAAYAELADRFFRFPVVYIEYSGTYGNPELVKAVREKLTNTVLYYGGGIDSREKAETMAKYANTIVVGNAVYKKGGIEKLKETIVK
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_STAAE
Sequence: MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTIEAISAAAIKFAQQFEENSTFKIDVKRADKNFPMDTYELQRELGGAVLKHFDNISVNVKRPDHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGALAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_PSEMY
Sequence: MATVDRWLLPDGIEEVLPPEAARIEAARRQVLDLFQRWGYEFVVTPHIEYLESLLTGAGQDLDLRTFKVTDPLSGRQMGFRADITPQVARIDAHTLRREGPNRLCYAGSVLHAQPRALTTSRSPIQLGAELYGDASPASDIEVISLLVETLELAAVPDVHMDLGHVGIYRGLARAAGLSGEVEQQLFDALQRKAMDEIEALTAALPAGLGNMLRSLAELCGGREVLDLAQAALVEAPDAVHAALDELVAIADALELRYPELPLYFDLGELRGYNYHTGVVFAAFVPGEGGAIAQGGRYDDTGAVFGRARPATGFSTDLKTLVTLGDMRLDEAVRGVWAPDNHDLYLWQAVRRLRSEGERVVQALPGQSEADAREAGCDRLLALRDGRWQVAPLAS
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUDI_ECOL5
Sequence: MRQRTIVCPLIQNDGAYLLCKMADDRGVFPGQWALSGGGVEPGERIEEALRREIREELGEQLLLTEITPWTFSDDIRTKTYADGRKEEIYMIYLIFDCVSANRDVKINEEFQDYAWVKPEDLVHYDLNVATRKTLRLKGLL
What is the function of this protein?
Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
What are the official names of this protein?
Nucleoside triphosphatase NudI, Nucleotide diphosphatase NudI, Pyrimidine deoxynucleoside triphosphate diphosphatase, dCTP diphosphatase, dTTP diphosphatase, dUTP diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudI subfamily.
Protein: TSAD_PROMH
Sequence: MRVLGIETSCDETGIAIYDDKAGLLANQLYSQIKLHADYGGVVPELASRDHIRKTVPLIQAALKEANLTAKDIDAVAYTAGPGLVGALLVGATIGRSLAFAWDVPAIPVHHMEGHLLAPMLEEKTPDFPFVALLVSGGHTQLISVTGIGEYTLLGESIDDAAGEAFDKTAKLLGLDYPGGPVLSKMAQQGVEGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRQNDDSEQTRADIARAFEDAVVDTLAIKCRRALEQTGFKRLVMAGGVSANRTLRAKMAMIMEQLGGEVFYARPELCTDNGAMIALAGMIRFKGGTEGPLGVTVRPRWPLAELPALADK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG3_PHANO
Sequence: MAYNFVRSYIDTFRERTAAISHTSTFRETGQITPEEFVLAGDFLVFKFPSWQWGDASSAGKRVPYLPEGKQYLMTRGVPCHRRLDDNFAGEAGQDETIVGDGFAGSEGADDDGWLRTGGMAASQEAKVRDVRTVDESGNLGAAEEEDEIPDMEDMDDDEEAIIRDPQGGSSSTAPLRTYTLYICYSAHYRTPRLYLSGYGATSVPLKPQEMMEDIVGDYKDKTVTIEDFPFFEHALKTASVHPCKHASVMKVLLDRADAALKLRLAKLKAGKDIGKLDTGMEGLVDDTRLLKLSEQAKGKEGDEAKDDWEVLSEGGDDEVAIRVDQYLVVFLKFMASVTPGIEHDFTMGV
What is the function of this protein?
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8.  The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE).  This step is required for the membrane association of ATG8.  The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt).  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
What are the official names of this protein?
Autophagy-related protein 3, Autophagy-related E2-like conjugation enzyme ATG3.
What is the protein family that this protein belongs to?
Belongs to the ATG3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLX4_MAGO7
Sequence: MTTPRFLPSSPPGQARSDLYTTLVSSSPDLPSINELVSRYAKKPKPLRSGSNAASIPTTATTTFTTAAKLLQSAQAEQADLVETLPPPRAKTKAKPKQKDPPEVVDLSPDLPVNIPEPQPERRKARKTANGVTKKKRGGGEESVADDATNEITTPTKNQPWKFFKSPSPRTTSDLEITGFQEVAATTAPVTTSTTDLTKGTASAQNKVTKSRVRKTSSAASRKKKAETVSRHFAVPDDVSTAPEPITVPDDAPEEQLFNLEPAVARRLDWTPPRETNTADLCPVSSNAKEVTSTLDGALSAAPAAVQNVFLTLQDKFAYPVEQVARRPDSPSKELGPPPEVIKKRKVIQLVGPSNDSKIPNQASPVKSKAPKKKPRTITDLATAAYTTEGKQSNAPAKKGTLTSYLEGQGEQVFQHCHPDSRLRKPERKRKPKGRGQVLLSPLSAIDQSARQDFVFGTSSQLAQEHSPTFLRDLHAALRQSNDFSDDPFASPIMAAPQGRKLWTAGARGEEGDLMNIEVIDLVDSPAFPDDPDAIVRAEMQKSPSRSEPKGIKNRRTPMVNLDSSEIDISEPHARDLESANSAEHTLKTQASKSTHFASTTPPRPTKITMVPACENTAEPPIVASDVDSDNEPPPSNQQAYQMPPPPRPVVPEETAIPRPNFEVMTDTQLSKQVSSYGFKSVKKRSAMIALLNQCWESKAGATGAAGQSSAFATTSRTSAPRGPRGKTSTAAAAAKSPTKRPVGRPRKNSVGASGDVTVVEATTPVKRPRGRPKKNAKAEASPDMMQNIAASMPPTVAAAVKTPRRRKKAATQPAVEILDSDGEAGLSPSPSLSPEPVFSSPEKDSVDVSIGEHTTMSLAVTPTAQQAELFTRITRAVKSAPRSTDPDKPSWHEKMLMYDPIVLEDLAAWLNSGQLDRVGYDGEVAPADVKMWCESKSICCLWRMSYRGRERKRL
What is the function of this protein?
Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX4.
What is the protein family that this protein belongs to?
Belongs to the SLX4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MURA_PSEU2
Sequence: MDKLIITGGVRLDGEIRISGAKNSALPILAATLLADGPVTVQNLPHLHDITTMIELFGRMGIEPVIDEKLSVEIDPRTIKTLVAPYELVKTMRASILVLGPMVARFGEAEVALPGGCAIGSRPVDLHIRGLEAMGAIIDVEGGYIKAKAPEGGLRGANFFFDTVSVTGTENIMMAASLANGRSVLQNAAREPEVVDLANFLIAMGAKIHGAGTDTITIDGVKRLGPATYKVMPDRIETGTYLVAAAVTGGRVKVKDTDPTILEAVLLKLQEAGAEVTTGEDWIELNMHGKRPKAVNVRTAPYPAFPTDMQAQFISLNAIAEGTGAVIETIFENRFMHVYEMHRMGAQIQVEGNTAIVTGTEVLKGAPVMATDLRASASLVISALVAQGDTLIDRIYHIDRGYECIEEKLQMLGAKIRRVPG
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.