PharMolix/UniProtQA huggingface dataset:
Protein: CO2A1_MAMAE
Sequence: GEPGGVGPIGPPGERGAPGNRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGAPGERGETGPPGPAGFAGPPGADGQPGAKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXVGPPGANGNPGPAGPPGPAGKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGFTGLQGLPGPPGTSGDQGASGPSGPAGPR
What is the function of this protein?
Type II collagen is specific for cartilaginous tissues.  It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
What are the official names of this protein?
Collagen alpha-1(II) chain, Alpha-1 type II collagen.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: Y4238_VEREI
Sequence: MAGHSKWANIQHRKGRQDEKRGRIWTRIMREITVAARAGGGDLSANPRLRLALDKARAANMPAERIKYNIDKATGNAEGQSYEEIRYEGYGIGGAAIIVDTMTDNRLRTVAEVRHAFSKHGANMGTEGSVVFQFKHCGQLVYAPGSSEDQVMEVALQAGAEDVIMGEDGAIEVLTLPADFEAVKNALQAAGLRPELAEVTMRAENTIELQGEDAARMQKLLDALEDLDDTQAVYHNATL
What are the official names of this protein?
Probable transcriptional regulatory protein Veis_4238.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRR17_ARATH
Sequence: MYSLSSVSKHLILVHILALVATQLLLIRSVSSLNMTNSYLNHKCFVSQGKYKPGSAHEKSLEAIIHSISVGENVNSGYDMMSFGDGPDLVCVVLQCRGDSYGSKCRSCFASAMAGLRRRCPRYKGGIIWFDQCLLEISSIDNVGQLNYGDSFCMSNAKNVGDDPFSFILKWDTLFDNISRIAITEKNKNLKDTNKPALYGAGEKRLGTKKKMYGMVQCTDDLSVKACEECLVANILKFQNCWKSGKRGARVLDRSCNFRYELYPFVNAKTGPNSYFKS
What are the official names of this protein?
Putative cysteine-rich repeat secretory protein 17.
What is the protein family that this protein belongs to?
Belongs to the cysteine-rich repeat secretory protein family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTPRC_RAT
Sequence: MYLWLKLLAFSLALLGPEVFVTGQGTTDDGLDTTEIVLLPQTDPLPARTTEFTPPSISERGNGSSETTYLPGFSSTLMPHLTPQPDSQTPSARGADTQTLSSQADLTTLTAAPSGETDPPGVPEESTVPETFPGGTPILARNSTAPSPTHTSNVSTTDISSGANLTTPAPSTLGFASNTTTSTEIATPQTKPSCDEKFGNVTVRYIYDDSSKNFNANLEGDKKPKCEYTDCEKELKNLPECSQKNVTLSNGSCTPDKIINLDVPPGTHNFNLTNCTPDIEANTSICLEWKIKNKFTCDIQKISYNFRCTPEMKTFALDKHGTLWLHNLTVRTNYTCAAEVLYNNVILLKQDRRVQTDFGTPEMLPHVQCKNSTNSTTLVSWAEPASKHHGYILCYKKTPSEKCENLANDVNSFEVKNLRPYTEYTVSLFAYVIGRVQRNGPAKDCNFRTKAARPGKVNGMKTSRASDNSINVTCNSPYEINGPEARYILEVKSGGSLVKTFNQSTCKFVVDNLYYSTDYEFLVYFYNGEYLGDPEIKPQSTSYNSKALIIFLVFLIIVTSIALLVVLYKIYDLRKKRSSNLDEQQELVERDEEKQLINVDPIHSDLLLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKDARKSQNQNKNRYVDILPYDYNRVELSEINGDAGSTYINASYIDGFKEPRKYIAAQGPRDETVDDFWKMIWEQKATVIVMVTRCEEGNRNKCAEYWPCMEEGTRTFRDVVVTINDHKRCPDYIIQKLSIAHKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLESLEAEGKVDVYGYVVNLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHSCLQNLKKRDPPSDPSPLEAEYQRLPSYRSWRTQHIGNQEENKKKNRSSNVVPYDFNRVPLKHELEMSKESEAESDESSDEDSDSEETSKYINASFVMSYWKPEMMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELMSGDQEVCAQYWGEGKQTYGDMEVMLKDTNKSSAYILRAFELRHSKRKEPRTVYQYQCTTWKGEELPAEPKDLVTLIQNIKQKLPKSGSEGMKYHKHASILVHCRDGSQQTGLFCALFNLLESAETEDVVDVFQVVKSLRKARPGMVGSFEQYQFLYDIMASIYPTQNGQVKKANSQDKIEFHNEVDGAKQDANCVQPADPLNKAQEDSKEVGASEPASGSEEPEHSANGPMSPALTPSS
What is the function of this protein?
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor.  Acts as a positive regulator of T-cell coactivation upon binding to DPP4.  The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.  Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity).  Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
What are the official names of this protein?
Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Protein: LDHA_SPHLU
Sequence: MSTKEKLIDHVMKEEPIGSRNKVTVVGVGMVGMASAVSILLKDLCDELALVDVMEDKLKGEVMDLQHGGLFLKTHKIVGDKDYSVTANSRVVVVTAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPNCILMVVSNPVDILTYVAWKLSGFPRHRVIGSGTNLDSARFRHIMGEKLHLHPSSCHGWIVGEHGDSSVPVWSGVNVAGVSLQTLNPKMGAEGDTENWKAVHKMVVDGAYEVIKLKGYTSWAIGMSVADLVESIVKNLHKVHPVSTLVKGMHGVKDEVFLSVPCVLGNSGLTDVIHMTLKPEEEKQLVKSAETLWGVQKELTL
What is the function of this protein?
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
What are the official names of this protein?
L-lactate dehydrogenase A chain, LDH-A.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VASH2_MOUSE
Sequence: MTGSAADTHRCPHPKITKGTRSRSSHARPVSLATSGGSEEEDKDGGVLFHVNKSGFPIDSHTWERMWLHVAKVHPRGGEMVGAIRNAAFLAKPSIPQVPNYRLSMTIPDWLQAIQNYMKTLQYNHTGTQFFEIRKMRPLSGLMETAKEMTRESLPIKCLEAVILGIYLTNGQPSIERFPISFKTYFSGNYFHHVVLGIYCNGYYGSLGMSRRAELMDKPLTFRTLSDLVFDFEDSYKKYLHTVKKVKIGLYVPHEPHSFQPIEWKQLVLNVSKMLRADIRKELEKYARDMRMKILKPASAHSPTQVRSRGKSLSPRRRQASPPRRLGRRDKSPALTEKKVADLGTLNEVGYQIRI
What is the function of this protein?
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868).  Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).  Plays a role in axon formation (PubMed:31235911).
What are the official names of this protein?
Tubulinyl-Tyr carboxypeptidase 2, Vasohibin-2, Vasohibin-like protein.
What is the protein family that this protein belongs to?
Belongs to the transglutaminase-like superfamily. Vasohibin family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cytoplasm, cytoskeleton. Note=Mainly localizes in the cytoplasm. Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion. Associates with microtubules (By similarity).
Protein: RNH2_CAMJJ
Sequence: MKTLFDTKELLNEFDINLIGIDEAGRGALAGPMMMAACKLNKQLDGLCDSKKLSEKKREELYEIIIKNSNYLILAFSSEQIDALGLSTCLKKGLKLIKKHFKTENNFLYDGNTNLGINGIKTQIKADTSILQVSAASILAKVSKDRVMNFLAKDFPCYEFEKNKAYGTKAHKEFIAKFGICKLHRKSFKLL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOSI_BACSU
Sequence: MKMKYGLYCMGSLVNTYDDAIEAHNDAVYAQEESGVPHEVREIQ
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YosI.
Protein: ETF2_VACCC
Sequence: MRYIVSPQLVLQVGKGQEVERALYLTPYDYIDEKSPIYYFLRSHLNIQQPEIVKRHILLTLRMTQLKGYLGNLLDIKDDIIIYSHKNNLEYSYVDNTIFNPFVYTQKKTLLKNDSFLYNVYPGACDFLVIWVVRACDTSIPEFGSYEDVDNNIIKFETMLMEVFPQLDLDITVESKFNNIFRTNLKLTGLKKIIQRVQDLDINYKSLLSRYDEHFINMTGNHFILNDEQLNLSIWDLDGTLALSSDGDTVMINNVKLFTDLVSDIDTQMERIKGDITYKVHLATPINSRIKLDIETSFIFIETATNNILLSSDKKISIILAKNHISIKVKNHIPNIEKYFTFLVIAINAMFNSVQKSADFTKVETVYWSRICQNTKNKNRKPIIINYLDPGMKKISNNFYRSDEKEVFINDNGIMFTCMDPLGKYNKVGFLNIFHDMRKYCIPCCFLHDQSHRSTFSSCVHQIDVEKKIVSPYILNFGKVVTESKMSFLPIIFDAFLNDGMTANMEQDNKRLKETSGYHIVRCCAGDDIVRLRTTSDIIQFVNEDKNILIVNDMVYFPMNASDIGKKIHILIQEIVHEVMIVKKKESSDKIDFFPPNYKLLKDLFPKQTIQTPIQSDAGMVLTTDGFYIDGKLFNEDLSSKYVTFTKNVIASDAVAKYFSPLFKYVISEAKDRFIKTWMINIMIHMNVDPNNIIPTLEKYYPNSGRAQIN
What is the function of this protein?
Acts with RNA polymerase to initiate transcription from early gene promoters.  Is recruited by the RPO-associated protein of 94 kDa RAP94/OPG109 to form the early transcription complex, which also contains the core RNA polymerase.  ETF heterodimer binds to early gene promoters.
What are the official names of this protein?
Early transcription factor 82 kDa subunit, ETF large subunit, VETF A7 subunit, Vaccinia virus early transcription factor large subunit, VETF large subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae VETF large subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity).
Protein: RBL_ANTAG
Sequence: MSPQTETKAGVGFKAGVKDYRLTYYTPDYETKDTDILAAFRMTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVAGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEAIFKSQAETGEIKGHYLNATAGTCEEMMKRAHFARELGMPIVMHDYLTGGFTANTTLARYCRDNGLLLHIHRAMHAVIDRQRNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGEREVTLGFVDLLRDDYIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMSALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNDIIREASKWSPELAAACEVWKEIKFVFETIDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: HIS3_PARDP
Sequence: MFDTASLKYDANGLIPAIAQDHQSGEVLMMAWMNAEAVRQTLDSGRVTYWSRSRQGFWVKGESSGHVQKLVELRVDCDRDCLLLLVDQTGPACHTNRRSCFYTAIREGQEVVIMAPQNPSA
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG14_VANPO
Sequence: MTIQCSVCRNHVQSMYCAHCINTSPNLLHPLRMQLLMVQQKNKVLKGKVEDILSHALDKNWKSSDNDTEGIILADRLHKLEVLKRTKRNNRVRYRISQLTKRIENKQQRLQSLRLQITTTDVAKVSNANKKEIEEIRTKYLQLNEVVKREQELECQSLVDWFILRKRNSYEIPYTLVFLPVVSLKNFHKLPKAVTISSLHKMFQFLEIYSQIISFPLLYKGDEIKEKTINTDEEIAKLITKLVINVLQIGRFKNLIPKDAIDLVWLLDQYDVDSLFYNVIVNHKMECRVVLFHWTFGKVSKVVTETLQLPAGSTTSFPRQQVGDTYDKDDDMWHIVG
What is the function of this protein?
Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I.  This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure.  ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity).
What are the official names of this protein?
Autophagy-related protein 14.
What is the protein family that this protein belongs to?
Belongs to the ATG14 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Protein: GET3_PODAN
Sequence: MSTAVINADDDAMEPTLQSILDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKDARKVDGFENLFAMEIDPNGSMQDLLAGQAEGEGAEGLGGMGGMMQDLALSIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALKKISQLSSQFGGVLNGLLGANGALPNGQNLGEMMEKLEALRATISEVNQQFKDERLTTFVCVCIPEFLSLYETERMIQELASYQIDTHCIVVNQLLFPKPGSDCEQCTARRRMQKKYLDQIEELYDEFNVVKMPLLVEEVRGKEKLEKFSEMLVKPFVPPS
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: VG53_ICHVA
Sequence: MPMMNTNVGFTRNTCFDDDFRSGRFVVRFEPLIEENAADQGAEIVNQNFLTGDERLLKLLFSSKTNLSHKYTTMKELVMKWNHFRDRFQREIVGRNSRGAALSRAEILQILLDIAQEKTGSTITRAYPRDVSWFFAQLVLGDVDTFVRAVKPAGLITSLTELPGLTTGTVGEGGQNDLYDLVDPSSYICDVHLRRDRSCEGKSIFLIAVPKQDPPLALENFRGLELKVIITDSSLQQVVRQTVADVPIESPRFAVAHLGQCFSRTLAHASFGGWKLYDARLLSRSIEALLPHVPDERPTPLKRIRLLV
What are the official names of this protein?
Uncharacterized protein ORF53.
Protein: EXBB_HELPY
Sequence: MGGFSVGMLKDYVDIFVFAVLGVASFLALWFAIERVIFYSKVDLKAYDDIDALNLDLTKNLTILYVIFSNAPYVGLLGTVLGIMVIFYDMGVSGGMDAKTIMVGLSLALKATALGLAVAIPTLIAYNSLLRKSDVLSEKFRIMKK
What is the function of this protein?
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.  Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
What are the official names of this protein?
Biopolymer transport protein ExbB.
What is the protein family that this protein belongs to?
Belongs to the ExbB/TolQ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SECB_ALCBS
Sequence: MADEQQQVFQLQRIYLKDTSFECPGAPEVFLQEWKPKVNVQLNNSARRVGEGDEFEVEITVTVTAKDEAEEKTFYLVEVKQAGIFTVKGIDGEERAQLLGAYCPNLLFPYVREVVSDLVAKGSFPQMVLQPINFDALYQQQRDQQQGNAAAAGETVQ
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_VIBC1
Sequence: MEAIINPIITKLYEQESLTQEESQQLFDIIIRGELDPILMASALTALKIKGETPDEIAGAAKALLANANPFPRPDYDFADIVGTGGDGHNTINISTTAAFVAAACGLKVAKHGNRSVSSKSGSSDLLDSFGINLAMSAEDTRKAVDEIGVAFLFAPQYHGGVRHAMPVRQTMKTRTIFNILGPLINPARPNIELMGVYSEELVRPIAETMLQMSMKRAAVVHGSGLDEVAIHGETTVAEIKDGKITEYTLTPADFGLEPHPLEAIKGGVPEENKAIITNILTGKGTDAQLGAVAVNVALLMRLFGHEDLKANTQQAVEAMNSGEAYQLVQQLAAHA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: FMT_BDEBA
Sequence: MSKVRVCFLGTPEFAVTSLKALLSDEHFEVVGVVTQPDRPAGRKLQLTPSPVKALAQAHNLKVLAPESLKANPLMLQEIKTWGAEVAVVVAFGQILTQEFLDSFRFGCVNVHGSVLPRWRGAAPIQRAIEAGDVESGVTLQKMVKKLDAGDIIGIRRVKITPDMNALQLHDVLAQLGAELLQVELMDYVRGNLAPTPQDESKVTLAKKIEKMESQIDWSTSAKAIDGKIRGFVYGPGTYTFLQGKKLKLHRATVTRDGGSIGSAKPGTITAVHEDHISVATGDGVLQLFEVQPESRNRMAIADFLKGHALKVGDQLGV
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: CYSG_PHOLL
Sequence: MDYLPIFVELKGRLVLLVGGGEVAARKATLLLRAGALLQVVAPELCSELQQRYQAGELEWYQGEFQPEYLDGIFLVIAATDDRILNHQVFSEADKRSILVNVVDDQVHCSFIFPSIIDRSPVLVAISSAGKAPVLARLIREKLEALLPSSLGTMAKIAGKWRERVKQRLTSMRQRRSFWEQAFNGRFAMLVANGQIQQAEKQLEQQLEQSDLQGELALVGAGPGDPGLLTLKGLQVIQQADVVLYDHLVSSDVLDLIRRDADKICVGKRAGNHSVSQEETNRLIVKFARQGKKVVRLKGGDPFIFGRGGEELQVAASAGIPFQVVPGITAAIGATAYAGIPLTHREHSQSITFITGHCREKGNELDWPALARGHQTLVIYMGTVKAALISHQLILHGRAEDTPVAVIGCGTRLEQQVLTGTLLELEQLAQQAPSPALLVVGEVAQLHHQIAWFGQQSIAKISRPAVVDFA
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: FKBP4_RHIO9
Sequence: MSVQGFWGLQLVPGKTYSQVVSAPFRITMASLAADAEAGKRTSVSVLVDEKEFVLCTLVPNKIEQQPLDITFVEGEEVTFSAKGQNNIHLTGNYVFQDDEDDEMGASMIDSDEEDNVEDFLKKLPPNASKEDINKALLGLEVDEEIESDEEVESDEEIESDEEIESEEEEEEPVPVSKKRPAEEVKEIASKKQKAEKKEQPKKEKSKKEEPKKEEPKKEQPKKEEPKKKEEPKKKEEPKKKEEPKKKEEPKKKEEPKKKEEPKKKEEPKKKITKLPNGLIIEDIKMGEGASCKNGQRVGMRYIGKLTNGKVFDKNVSGKPFSFLLGRGEVIKGWDLGIAGMKAGGERKLTIPAPLAYGKRGAPPDIPKNATLVFDVKLLSMK
What is the function of this protein?
PPIase that acts as a histone chaperone.  Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail.  Proline isomerization influences H3 methylation thereby regulating gene expression.
What are the official names of this protein?
FK506-binding protein 4, Histone proline isomerase, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATP4B_CANLF
Sequence: MAALQEKKSCSQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGIFALCIYTLMCTLDPYTPDYQDQLKSPGVTLRPDVYGEKGLDISYNVSDNRTWVDLVNILHNFLEGYSPTSQEDNINCTSEKYFFQDVFGAPNHTKFSCKFMADMLQNCSGLTDPNFGFAEGKPCFIIKMNRIVNFLPSNSTAPRADCTFLDQHKDDRPLQVEYYPPNGTFSLRYFPYYGKKAQPHYSNPLVAAKLLNVPRNTEVLIVCKILADYVTFDNPHDPYEGKVEFKLTIQQ
What is the function of this protein?
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells.  Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity).  Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2).  Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity).
What are the official names of this protein?
Potassium-transporting ATPase subunit beta, Gastric H(+)/K(+) ATPase subunit beta, Proton pump beta chain.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type II membrane protein. Cell membrane; Single- pass type II membrane protein. Note=Localized in the apical canalicular membrane of parietal cells.
Protein: RL31_MESM1
Sequence: MKPNIHPEYKNITLTCSTCEKKHIFGSTAKKSSVDVCSNCHPFFTGDRSIQRTTGRVDRFNRRLTKSAEK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: SHO1_ARTBC
Sequence: MARFQMSNLVGDPFALATVSIGMLAWIIGVVSCSIAHTKEVVPNFFWWSIAYQLCVLVGVAVVMGSNTSHIYGTAVVGYAAAGLVCTTFTLDSLVTSKQGARQSAGAGLILLAMTDIVWIFYFGSTSQSGPRAYIDSFAPHKEQPHSYRNSKPISHSYTPRPETTVSSAHPHMYSSAPLSGFETSSPMTGFNPAAASTTGLQPVLGSQTNASTVGGETGEVGQPTEYPYRAKAIYSYEANPDDANEISFTKHEILEVSDVSGRWWQAKKSTGETGIAPSNYLILL
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.
What are the official names of this protein?
High osmolarity signaling protein SHO1, Osmosensor SHO1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KATG_SALPA
Sequence: MSTTDDTHNTLSTGKCPFHQGGHDRSAGAGTASRDWWPNQLRVDLLNQHSNRSNPLGEDFDYRKEFSKLDYSALKGDLKALLTDSQPWWPADWGSYVGLFIRMAWHGAGTYRSIDGRGGAGRGQQRFAPLNSWPDNVSLDKARRLLWPIKQKYGQKISWADLFILAGNVALENSGFRTFGFGAGREDVWEPDLDVNWGDEKAWLTHRHPEALAKAPLGATEMGLIYVNPEGPDHSGEPLSAAAAIRATFGNMGMNDEETVALIAGGHTLGKTHGAAAASHVGADPEAAPIEAQGLGWASSYGSGVGADAITSGLEVVWTQTPTQWSNYFFENLFKYEWVQTRSPAGAIQFEAVDAPDIIPDPFDPSKKRKPTMLVTDLTLRFDPEFEKISRRFLNDPQAFNEAFARAWFKLTHRDMGPKARYIGPEVPKEDLIWQDPLPQPLYQPTQEDIINLKAAIAASGLSISEMVSVAWASASTFRGGDKRGGANGARLALAPQRDWEVNAVAARVLPVLEALQKTTNKASLADIIVLAGVVGIEQAAAAAGVSISVPFAPGRVDARQDQTDIEMFSLLEPIADGFRNYRARLDVSTTESLLIDKAQQLTLTAPEMTVLVGGMRVLGTNFDGSQNGVFTDRPGVLSTDFFANLLDMRYEWKPTDESNELFEGRDRLTGEVKYTATRADLVFGSNSVLRALAEVYACSDAHEKFVKDFVAAWVKVMNLDRFDLL
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RL2_STRPQ
Sequence: MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVSLKSKAGRNNNGRITVRHQGGGHKRHYRLIDFKRNKDGVEAVVKTIEYDPNRTANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPDADIKVGNALPLANIPVGTVVHNIELKPGKGGELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATIGTVGNEQQSLVNIGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: P2C59_ORYSJ
Sequence: MREVLLLGSLVVLALLSLFPCCSCLSQGAEEEEDDGEVRLMGLAGEAAGSPGSGGGFSANGKFSYGYASSPGKRSSMEDFYDTRIDGVDGETVGLFGVFDGHGGARAAEFVKQNLFTNLIKHPKLFSDTKSAIAETYTSTDSELLKAETSHNRDAGSTASTAILVGDRLLVANVGDSRAVICRGGDAIAVSRDHKPDQSDERQRIEDAGGFVMWAGTWRVGGVLAVSRAFGDKLLKQYVVADPEIKEEVVDSSLEFLILASDGLWDVVTNEEAVAMVKPILDSEQAAKKLLQEASQRGSADNITCLVVRFLEQENHLPERPTNDQAS
What are the official names of this protein?
Probable protein phosphatase 2C 59, OsPP2C59.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.