PharMolix/UniProtQA huggingface dataset:
Protein: CDK2H_PLAYO
Sequence: MEKYHGLEKIGEGTYGVVYKAQNSDGESFALKKIRLEKEDEGIPSTVSIREISILKELRHSNIVKLYDVIHAKKRLILVFEHLDQDLKKLIDVCDGGLESVTAKSFLLQLLNGIAYCHEHRVLHRDLKPQNLLINREGELKIADFGLARAFGIPARRYTHEVVTLWYRAPDILMGSKKYSTPIDIWSVGCIFAEMVNGRPLFPGVSETDQLMRIFKILGTPNSQNWPDVFKLPKYDPNFPVYEPLPWETFIKGLDDTGIDLLSKMLKLDPNQRITAKQAIEHPYFKETN
What is the function of this protein?
Serine/threonine-protein kinase (By similarity).  Involved in the control of the cell cycle.  Required for entry into S-phase and mitosis (By similarity).  Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 2 homolog, Cell division control protein 2 homolog, cdc2-related kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPHP1_CAEEL
Sequence: MSIFGSILSLQDAINRFPQFEYQINRLEKEQKDTEAASRASFRKHFVRQCQELHRQLDDHRNRIEKAKTDETYKKENALEQLDKLKQRLTALSPEKEQLSFSVSVDSQSEEEKPKMAAIGRRKSTMYNDDESEDSDNDSEIIETDVQLDDPLPSQPQPPQQQHQQPQPKPRQPITITKPLESKTLNERQELDEVISRLQNPSRGDSGEVMEPVVVRGNVFVAIDSWDAEAEGDLELIKGKKYRITQTRSDGWWTALDEYGQRGLVPKTYLQHVKEKPKNVPSKVSSRLGVRDSVIGISTTTDPSRREANRQASRVDDCLGKAYDNDTHLSLVCHMAPRLSTSNIGFHDLFWSHYKDQVYKRTVHISKIIRLVRFEKMPLIEHKALVRMALVDITNPKSTQIVSNVHTLVPRVKSSTWYFEKKESQTRSCIEFSDFVLRSNYRSPTVVLVVEASHLVKTQIGIEEKSLGHTYLRLIIDDKAVPSRTNVLYLDDEVMTKMKLPEASKRRVLVQVMDVPKDKVSYVDSLPDVIVFNALYLPFFHFYRRRAGTILIRDNRNPLSAEFISDPLLSVFPFVCDQHDIMDIMLKIWKTKKKVLAKKNEAEQTAEFFQTFLHTAFFIHGIRMISYDVKDDLTLSIRQQTMQRFVDALNKGLFKQFIADQQCKPINIIDYSLDLLGNHSID
What is the function of this protein?
Plays a role in the extension of dendrites from phasmid ciliated sensory neurons (PubMed:34115759).  May be necessary for initial assembly of the cilium.
What are the official names of this protein?
Nephrocystin-1-like protein, Nephronophthisis homolog.
What is the protein family that this protein belongs to?
Belongs to the nephrocystin-1 family.
Protein: MUTS2_CLOBK
Sequence: MKDKSIKVLEFNKIQEFLKNYTCTKAAKDIIEDLKPYDSVYEVREHLEETKEAFKLLITKGAPPFEGVYDIRSGISLAEKRSTLLPGQLLKIAAVLRCARRFKEYINHKEEEESYRVLENICEGIFSLPKIEEEIFNAIEGEDEIADRASSTLYNIRRSLKEKNYSVRDKINSLVRSYSSYLQENIYTVRGDRYVLPVKAEHKGAVPGLVHDQSSTGATLFIEPMSLVNLNNEIKELMLKEKAEIERILTVLSAKINANITGVKTDANIVWELDFIFAKAKFASEYNCTCPTINDEGIVDIIEGRHPLIDRREVVPISVKLGEEFTSLMITGPNTGGKTVTLKTVGLIHLMAMSGLMIPARENSVISYFNNVFADIGDEQSIEQSLSTFSSHMKNIVEIMDKADENSLVLFDELGAGTDPTEGAALAISILENLRKRGTKIIATTHYSELKAYALKKEGVENASVEFDVETLRPTYRLLIGIPGKSNAFEISKRLGLPDYIIDFARENISNENIRFEELIENLQEKSIKAQEDARLAENLKLERDKEKKKYEEKLEGLQKVRDNALIDARREAKNIIKEAKEEADKILKDIRQLERMGYSSDARRKLEEERKKLKDKLDSIEEKEIKTVHKGEALKNVKEGDEVLLASINQKVIVLSKPDNKGDVLVQAGIMKITANIKDLRAAKGSNSNSSSSKIKKSKKLNLNLRRVESSVDLRGMDAEEAIYTVDKYLDEAYLGGLGEVTIVHGKGTGVLRKTIMDMLKGHSHVKKYRLGEYGEGGTGVTVVELK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: GL21_ARATH
Sequence: MASPTLTLLLLLTTVSFFISSSADPDMLQDLCVADLPSGIKINGFPCKDAATVTSADFFSQGLAKPGLTNNTFGALVTGANVMTIPGLNTLGVSLSRIDYAPGGLNPPHTHPRATEVVFVLEGTLDVGFLTTANKLISQSLKKGDVFAFPKGLVHFQKNNGDVPASVIAAFNSQLPGTQSLGATLFGSTPPVPDNILAQAFQTSPGTVKHIKSKFQPKK
What is the function of this protein?
May play a role in plant defense.  Probably has no oxalate oxidase activity even if the active site is conserved.
What are the official names of this protein?
Germin-like protein subfamily 2 member 1.
What is the protein family that this protein belongs to?
Belongs to the germin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: EFTS_STAAT
Sequence: MATISAKLVKELREKTGAGMMDCKKALTETDGDIDKAIDYLREKGIAKAAKKADRIAAEGLVHVETKGNDAVIVEINSETDFVARNEGFQELVKEIANQVLDTKAETVEALMETTLPNGKSVDERIKEAISTIGEKLSVRRFAIRTKTDNDAFGAYLHMGGRIGVLTVVEGSTDEEAARDVAMHIAAINPKYVSSEQVSEEEINHEREVLKQQALNEGKPENIVEKMVEGRLRKYLQEICAVDQDFVKNPDVTVEAFLKTKGGKLVDFVRYEVGEGMEKREENFADEVKGQMK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_LEGPH
Sequence: MIVQDSVCSELMRGCEEILPVPELEKKLQKGIPLKIKAGFDPTAPDLHLGHTVLLNKLRQFQQFGHEVIFLIGDFTAMIGDPTGKNVTRMPLSQETVLENAKTYQHQVFKILDPDKTTVAFNSQWLNKFNAVDLIRLAATHTVARMLERDDFNKRYTTGQPIAIHEFLYPLLQGYDSVALKADVELGGTDQKFNLLMGRELQKHYGFEPQVVMMTPLIEGLDGVKKMSKSLDNYIGINETPEQMFGKIMSVSDELMWRYIDLLSFKTGKEIQQLKQSVLEGKNPRDVKIDFAKEIVARFHDQTQAEFAHNKFIERFQKGNIPEDLEELSLVIAEPIALAQLLKQIDLTASTSESIRMVKQGAVKVDGDKISDPSLKLPIGKSYIIQVGKRRIAKLSIQQAD
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_DESRM
Sequence: MEKLEMIYEGKAKKVYRTDNPDFYWVEYKDDATAFNGQKKGTIDNKGVVNNKVSAVFFKLMESKGITTHFVELVNDREMIVKALDIIKVEVVVRNIVAGTLAKRVGLPEGTILPKTVLEYYYKDDNLGDPLINASHIAALDLATPEQMAFIKETALKVNDIMREYLAPVNIDLIDYKLEFGLHKGQVLLGDEISPDTCRFWDKTTGEKLDKDRFRRDLGNVEGAYQEVLRRLTGEA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ADT2_RAT
Sequence: MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFKGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIFISWMIAQSVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).  In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity.  Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis.  Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity).  Proton transporter activity requires free fatty acids as cofactor, but does not transport it.  Probably mediates mitochondrial uncoupling in tissues that do not express UCP1.  Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1. 5 kDa, and which contributes to cell death.  It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it (By similarity).  Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity).  As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).
What are the official names of this protein?
ADP/ATP translocase 2, ADP,ATP carrier protein 2, Adenine nucleotide translocator 2, ANT 2, Solute carrier family 25 member 5.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=May localize to non-mitochondrial membranes.
Protein: DFC_ARATH
Sequence: MAKSFVPLIAVLCVLVLPLAAMAVGTPFHIEGSVYCDTCRFGFETIATQYIRGARVRIVCKDRVTLKSELVGVAVTGPDGKYKVAVRGDRQDQQCLAELVHSPLSRCQEADPGRSTATVILTRSNGAASTRHYANAMGFFRDEPLRGCAALRKRYLADGDNRAI
What is the function of this protein?
Part of a three-gene cluster containing FLC, UFC and DFC, which is coordinately regulated in response to vernalization.  Not regulated by FLX.
What are the official names of this protein?
Protein DOWNSTREAM OF FLC, AtDFC, Pollen allergen-like protein.
What is the protein family that this protein belongs to?
Belongs to the Ole e I family.
What are the subcellular locations of this protein?
Secreted.
Protein: GUAA_HERAR
Sequence: MHSKILILDFGSQVTQLIARRVRDSGVFSEVYPYDVSDEFVRNYGAAGVILSGGPNSVIEGDESPRVPQAVFELGVPVLGICYGMQAMAEQLGGKVENGTVREFGYAEVRAHGHTALLKDISDFTTPEGHGMLKVWMSHGDKVNEMPPGFKLMASTPNCPIAGMADEARHMYAFQFHPEVTHTLQGKAIIARFVHDICGCKSDWNMPDYIAEAVEKIRQQVGNDEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLDEGKMVMEMFADHLGVNVIRIDAVDQFMGHLAGVTDPEAKRKIIGREFVEVFQVEAGKRKNAKWLAQGTIYPDVIESAGKGKKGHTIKSHHNVGGLPETLNLQLLEPLRELFKDEVRQLGVALGLPHDMVYRHPFPGPGLGVRILGEVKKDFADLLRRADAIFIEELRNTPYVLAAGASESTDNGIPHRNWYDATSQAFAVFLPVKSVGVMGDGRTYEYVVALRAVQTQDFMTAHWAHLPYELLGKVSNRIINEVRGINRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: NSUN7_MOUSE
Sequence: MLDPTSERDLFDQENMEEISQLASLEMSGDVVANTNSTVVLEKPSYPDSVYVTAANIFQGIRIQRSPDKVIINYGSEPLQPSSSRSEDESFQRLSYELAFSTLKYQDILESILIDSYIFSSTTIASQLNSLIIVMLYDFQDRKFQPRILSENEETIPEVQEVENLLNGFKTKLAAALARCRIKHDALSIYHILPETVRKQEQRASTLPLYAWINTSKISLEEVYNNLRRKGYSKVKSITSVNEKVYAVDQHCFNVLIFPAHLKTDLLNIDLIKDYKLIFQDKSRSLAVHSVKALINIDDDVLMVNTGSWYTVAHMSILTSGHTSKIFVCGIQQEEKDFNARKLFTRMGCQNIEILHETFLSIESKDHRLQNVKVILLLPRCSSLGVSNPVEFILNEHEDKSLLQDLSQGGLPKDKLETLVQQQFEQLTHAMKFTKVQAIVYCTCSVSKEENEDVVEKALEYQSSGVKMQPYRLSPPVLPLCTLKEIELSMDRFFRLEPSDMNNGCFLSILTRERDPSETVSVKDVLARAAAKGLLEGVEVGKTLKRDKKRKKSKALPSRAPHHGDPLRDHLAVDGNDTSNVQMKISELLHRESKISTSTKMSAPAKTVSQAGTSSQVRKPSKPLSTPLVRNFSRPVERPTNFVRARPEGKVIPLKPIEIVLPPVIFPLSSQGPRVQMPATHFYYRFIGSKVGVPRYLTSSTSRRKEKVKESTTSSHVRHPRPWL
What is the function of this protein?
May have S-adenosyl-L-methionine-dependent methyl-transferase activity.
What are the official names of this protein?
Putative methyltransferase NSUN7, NOL1/NOP2/Sun domain family member 7.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Protein: CLP1_CULQU
Sequence: MGEEREATRTEYKLEMDSELRFEIENKNEKVTVTLMNGHAELFGTELVMRKPYEFGVGAKVAIFTYHGCTIELRGKPDVAYVARETPMVQYLNSNSALEHLRAKAEQDDTQGPVVMIVGPMDVGKTTLCRIFLNYAVRLGRRPIYVDLDVGQGGIAIPGTIGALLVERPAPVAEGFSQQAPLVYHFGHTSPSDNDVFYGVLISKLAETTLERLEANKKAKYSGMIINTCGWVKGGGYRHILHAIKAFEVNAVFVLDQERLYNELLRDVERAVQIVFLPKSGGVVERTKSQRAEARDNRVREYFYGSKMPLYPHSFDVKFSDVKIFKVGSPALPDSCLPLGMKREDNYTKLVAVQPGPQLLHHILAVSFAESTDDNVIQSNVAGFICVTNVSMEKEVLTILSPQPRPLPQTILLVSDFQFMDSH
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
Protein CLP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: EUME_EUMRU
Sequence: LNLKGIFKKVASLLT
What is the function of this protein?
Cationic linear alpha-helical antimicrobial peptide that binds preferentially to charged lipid membranes as compared with zwitterionic ones.  It exhibits inhibitory activity against both Gram-positive and Gram-negative bacteria, and moderately stimulates degranulation from the rat peritoneal mast cells.  Does not show hemolytic activity.  May play a role in preventing infection by microorganisms during prey consumption by their larvae.
What are the official names of this protein?
Eumenitin, Er-12.
What is the protein family that this protein belongs to?
Belongs to the MCD family. Eumenitin subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Assumes an amphipathic alpha-helical conformation in a lipid environment. Forms a membrane channel in the prey.
Protein: PT1_MYCCT
Sequence: MSKQIKGIAASEGISLARALVIKETKLDIQKQLISDVDQEIIKLEQAIEKSIADLKKIQQITLKKLGEEKAAIFDAHQDIANDPAIKEEVVELIKKEKVNAEYALFTVSNNYFEMFSQLEDPYFKERSADIKDVSLRIISHILGLEIHDLSTIDKEVIIISDDLTPSQTAQLDKKFVKGFLTNVGGRTSHAAIMARSLEIPAILGLKNITELVKTDDLIALDGSSGIVELDLNDDDIKNYQTKVQQYIELKEQLKKFKDEPSLTKDKIKKLIEANIGSTNDVQSVLDSGAEGIGLFRTEFLYMDNDHFPTEEEQFEAYKKVVSQIKHLVVFRTLDIGGDKKLSYFKFDEEMNPFLGYRAIRFTLDRKDIFKDQIRALLRASAFGKLGIMFPMIATIDEFKQAKTFVEECKIELDKEGIKYDNQVQIGMMVEIPSAAILADQFAKYADFFSIGTNDLIQYSFASDRMNQNVSYLYQPLNPSLLRLIQLTISGAHKHNKWVGMCGEMAGDSKALPILLGLDLDAFSMSATSVLKARSLMSKIEFSKAKILANKVLECETNEQVNKLVEDFLNNLD
What is the function of this protein?
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS).  This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
What are the official names of this protein?
Phosphoenolpyruvate-protein phosphotransferase, Phosphotransferase system, enzyme I.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_HAMD5
Sequence: MRIILLGAPGAGKGTQAQFIMKKYGIVQISTGDMLRAAVKAGTKLGQQVQGIMAAGKLVTDDLVIALVKERIRQEDCKEGFLLDGFPRTIPQADAMAEADIKIDYVLELVVPDEFIVERISGRRVHMPSGRIYHLKFNPPKITDKDDMTGESLTLRKDDQETTVRERLLEYHQQTMALVDYYRQRAKRGDTKYFKLDGTRTVNEVSQQLSSILGES
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIKI1_XENTR
Sequence: MVIIWNIFLPAFLLVLAKASLRSSRDSANCKLNKKQSQLNSFLWTIKRDPPSYFFGTIHVPYTRVWDFIPENSKTAFQQSNIVYFELDLTDPYTISALTSCQMLPQGENLQNVLPRDIYRRLKRHLEYVKLMMPSWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEVDIKSRGVPVLDLYLAQEAERLKKRTGAVEQVEEQCHPLNGLNLSQVIFALNQTLLQQENLRAGSVQVPYSTEDLIKHYNCGDLNSIIFNHDSSQVPNFINSTLPPQERITAQEIDNYFRQELIYKRNERMGKRVKDLLEQFPEKSFFFAFGAGHFLGNNTVIDVLKRYGYDVLHTPAGRSIINNGKGKKNLLPSKFSSSSLPVGLSAPPCTVTSRIKQSINSHKDQESLPDILLDDDIDQLDKDERKYKKRKQRKEKHRHFSDLWVRIQESSTDTTPQIRIINGYITVEPHPREHGKDKYIKAAQSVSFSLSIPSAFLLLAWCFQQVAVLQ
What is the function of this protein?
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway: expressed in the Spemann-Mangold organizer and is required for anterior-neural patterning in head formation in embryos.  Acts by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins.  Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.  Able to cleave wnt8.
What are the official names of this protein?
Metalloprotease TIKI1, TRAB domain-containing protein 2A.
What is the protein family that this protein belongs to?
Belongs to the TIKI family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CRIM2_ARATH
Sequence: MASLCLSSSRIVSLHHQKPFLALKLRPRPSNISGLGHSTSVVCFNPLRLSADRQRTATVSARAEKRRKRGSSVVCYATPMLSVHNLQWISTISCVALMFARGTGIHKSFVVPLFALQAPMGIVSWMKGEYGIWAAFLALLTRLFFSFPVELELPFIALLLVIVAPYQVMSIRGKQEGAILSLAISCFLAFQHFSRAGTLQKAFDQNSVLATVAIIGVTVVSFLFLI
What are the official names of this protein?
Cold-regulated 413 inner membrane protein 2, chloroplastic, AtCOR413-IM2, Cold-regulated 413 thylakoid membrane 2, AtCOR413-TM2.
What is the protein family that this protein belongs to?
Belongs to the Cold-regulated 413 protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: MRAZ_ECOBW
Sequence: MFRGATLVNLDSKGRLSVPTRYREQLLENAAGQMVCTIDIHHPCLLLYPLPEWEIIEQKLSRLSSMNPVERRVQRLLLGHASECQMDGAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWHQQVKEDIDAEQLATGDLSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ODPA_STAES
Sequence: MAPKLQAQFDAVKVLNETQSKFEMVQILDEDGNVVNEDLVPDLTDEQLVELMERMVWTRILDQRSISLNRQGRLGFYAPTAGQEASQLASQYALESEDFILPGYRDVPQIIWHGLPLTDAFLFSRGHFKGNQFPEGVNALSPQIIIGAQYIQTAGVAFGLKKRGKNAVAITYTGDGGSSQGDFYEGINFASAYKAPAIFVIQNNNYAISTPRSKQTAAETLAQKAISVGIPGIQVDGMDALAVYQATLEARERAVAGEGPTVIETLTYRYGPHTMAGDDPTRYRTSDEDAEWEKKDPLVRFRKYLEAKGLWNEDKENEVVERAKSEIKAAIKEADNTEKQTVTSLMDIMYEEMPQNLAEQYEIYKEKESK
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit alpha.
Protein: RNF13_RAT
Sequence: MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFEDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPLKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIDILKKIDIPSVFIGESSANSLKDEFTYEKGGHVILVPELSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRNRRNRLRKDQLKKLPVHKFKKGDEYDVCAICLEEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENQVSEHTPLLPPSASARTQSFGSLSESHSHHMTESSDYEDDDNEETDSSDADNEITDHSVVVQLQPNGEPDYNIANTV
What is the function of this protein?
E3 ubiquitin-protein ligase that regulates cell proliferation.  Involved in apoptosis regulation.  Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA.  Also involved in protein trafficking and localization.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF13, RING finger protein 13.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Nucleus inner membrane; Single-pass type I membrane protein. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane.
Protein: ADDB_STAAM
Sequence: MTLHAYLGRAGTGKSTKMLTEIKQKMKADPLGDPIILIAPTQSTFQLEQAFVNDPELNGSLRTEVLHFERLSHRIFQEVGSYSEQKLSKAATEMMIYNIVQEQQKYLKLYQSQAKYYGFSEKLTEQIQDFKKYAVTPEHLEHFIADKNMQTRTKNKLEDIALIYREFEQRIQNEFITGEDSLQYFIDCMPKSEWLKRADIYIDGFHNFSTIEYLIIKGLIKYAKSVTIILTTDGNHDQFSLFRKPSEVLRHIEEIANELNISIERQYFNQLYRFNNQDLKHLEQEFDVLQINRVACQGHINILESATMREEINEIARRIIVDIRDKQLRYQDIAILYRDESYAYLFDSILPLYNIPYNIDTKRSMTHHPVMEMIRSLIEVIQSNWQVNPMLRLLKTDVLTASYLKSAYLVDLLENFVLERGIYGKRWLDDELFNVEHFSKMGRKAHKLTEDERNTFEQVVKLKKDVIDKILHFEKQMSQAETVKDFATAFYESMEYFELPNQLMTERDELDLNGNHEKAEEIDQIWNGLIQILDDLVLVFGDEPMSMERFLEVFDIGLEQLEFVMIPQTLDQVSIGTMDLAKVDNKQHVYLVGMNDGTMPQPVTASSLITDEEKKYFEQQANVELSPTSDILQMDEAFVCYVAMTRAKGDVTFSYSLMGSSGDDKEISPFLNQIQSLFNQLEITNIPQYHEVNPLSLMQHAKQTKITLFEALRAWLDDEIVADSWLDAYQVIRDSDHLNQGLDYLMSALTFDNETVKLGETLSKDLYGKEINASVSRFEGYQQCPFKHYASHGLKLNERTKYELQNFDLGDIFHSVLKYISERINGDFKQLDLKKIRQLTNEALEEILPKVQFNLLNSSAYYRYLSRRIGAIVETTLSALKYQGTYSKFMPKHFETSFRRKPRTNDELIAQTLTTTQGIPINIRGQIDRIDTYTKNDTSFVNIIDYKSSEGSATLDLTKVYYGMQMQMMTYMDIVLQNKQRLGLTDIVKPGGLLYFHVHEPRIKFKSWSDIDEDKLEQDLIKKFKLSGLVNADQTVIDALDIRLEPKFTSDIVPVGLNKDGSLSKRGSQVADEATIYKFIQHNKENFIETASNIMDGHTEVAPLKYKQKLPCAFCSYQSVCHVDGMIDSKRYRTVDETINPIEAIQNININDEFGGE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB, DNA 3'-5' helicase AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: RNH2_CLOBL
Sequence: MNLNNLENIRYNEIKEFSDKIKKEFTFFQKKQVMDIIEKLNKDPRKNVIKLGQALEKFLNKYEEELKRTNNMYNFDRRYGNNYLIAGVDEVGRGPLAGPIVAAAVVLDLNVEEMQRIFNIKDSKKLSEKKREELDIIIREKAISYNIALVDNKTIDERGISWSNNEVLKRAVEGLKVKPDLVLSDGYAVKNLNIRNEFIIKGDSKSISIASSSIIAKVYRDNMMKEYSKGLNMYGFNHNAGYGTEEHVQAIKKYGPSKIHRMSFLTNIL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSPB1_CANLF
Sequence: MTERRVPFSLLRSPSWDPFRDWYPAHSRLFDQAFGLPRLPEEWAQWFGHSGWPGYVRPIPPAVEGPAAAAAAAAPAYSRALSRQLSSGVSEIRQTADRWRVSLDVNHFAPEELTVKTKDGVVEITGKHEERQDEHGYISRRLTPKYTLPPGVDPTLVSSSLSPEGTLTVEAPMPKPATQSAEITIPVTFEARAQIGGPEAGKSEQSGAK
What is the function of this protein?
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state.  Plays a role in stress resistance and actin organization.  Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.
What are the official names of this protein?
Heat shock protein beta-1, HspB1, Heat shock 27 kDa protein, HSP 27.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.