Protein: TISB_RAT
Sequence: MTTTLVSATIFDLSEVLCKGNKMLNYSTPSAGGCLLDRKAVGTPAGGGFPRRHSVTLPSSKFHQNQLLSSLKGEPAPTLSSRDSRFRDRSFSEGGERLLPTQKQPGSGQVNSSRYKTELCRPFEENGACKYGDKCQFAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRALAGGRDLSADRPRLQHSFSFAGFPSAAATAAATGLLDSPTSITPPPILSADDLLGSPTLPDGTNNPFAFSSQELASLFAPSMGLPGGGSPTTFLFRPMSESPHMFDSPPSPQDSLSDHEGYLSSSSSSHSGSDSPTLDNSRRLPIFSRLSISDD
What is the function of this protein?
Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:10751406, PubMed:12748283).  Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:12748283).  Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:12748283).  Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (PubMed:11279239).  Binds to 3'-UTR ARE of numerous mRNAs (PubMed:10751406).  Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs).  Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress.  Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA.  Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA.  Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation.  May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA.  In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation.  Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.  Participates in the delivery of target ARE-mRNAs to processing bodies (PBs).  In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells.  Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion.  Plays a role in vasculogenesis and endocardial development.  Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis.  Plays a role in myoblast cell differentiation (By similarity).
What are the official names of this protein?
mRNA decay activator protein ZFP36L1, Butyrate response factor 1, EGF-inducible protein CMG1, TPA-induced sequence 11b, Zinc finger protein 36, C3H1 type-like 1, ZFP36-like 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasmic granule. Cytoplasm, P-body. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. Component of cytoplasmic stress granules. Localizes in processing bodies (PBs).