PharMolix/UniProtQA huggingface dataset:
Protein: AUSI_PENBI
Sequence: MLHETISLALLGQPLVPGLMVVSAILYLLYSTQQWRPKNLPLLNDAGPFDFLQATAVKRFRRDARQLIKSGFDSYNNVFAMRTDVGVELFASPEYADQFRNHPSLKVFPFTAKMHHGHLPGFELCRSQPVEDRILIESVRTQLAQSLGKMIQPLASDIGQAISDRWPSESGWQEIALGSVIERTIAQGTSSVYCLDEAWPEFVVKMEMALGMASAALSAWPVMLRRVVAKFLPECLELYRIMDAGRELMSRDMRRRVALQASTGEAPLNFFEWFKEASHGEEYDELILNLRIAFASMHGLCDHLVKILLRLSEDPQLVDDLRKEVIQVYKTHGWSKTALYHLKLMDSTFKEVQRVDPILFAVGRLAVADVALKDGLIIPKGQSIRISGHTMWDEDKYPDAAHFDAYRFYKLRQAPGQENTAQFTSPTSDHLGFGYGGRACPGRFFAAAVLKISLCHVLMKYDIKPANGETGPHVWEFAAAINANMTANVLVRRREPEIRL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster B that mediates the biosynthesis of the fungal meroterpenoid acetoxydehydroaustin (PubMed:29076725).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (By similarity).  3,5-dimethylorsellinic acid is then prenylated by the polyprenyl transferase ausN (By similarity).  Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (By similarity).  Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (By similarity).  Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (By similarity).  The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (By similarity).  The cytochrome P450 monooxygenase ausG then modifies austinolide to austinol (By similarity).  Austinol is further acetylated to austin by the O-acetyltransferase ausP, which spontaneously changes to dehydroaustin (PubMed:29076725).  The cytochrome P450 monooxygenase then converts dehydroaustin is into 7-dehydrodehydroaustin (PubMed:29076725).  The hydroxylation catalyzed by ausR permits the second O-acetyltransferase ausQ to add an additional acetyl group to the molecule, leading to the formation of acetoxydehydroaustin (PubMed:29076725).  Due to genetic rearrangements of the clusters and the subsequent loss of some enzymes, the end product of the Penicillium brasilianum austinoid biosynthesis clusters is acetoxydehydroaustin (PubMed:29076725).
What are the official names of this protein?
Cytochrome P450 monooxygenase ausI, Austinoid biosynthesis clusters protein I.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: BBS_PHASS
Sequence: MLSLESIKKAPRADGFASILAIGRANPDNIIEQSAYPDFYFRVTNSEHLVDLKKKFQRICEKTAIRKRHFVWNEEFLTANPCFSTFMDKSLNVRQEVAISEIPKLGAKAATKAIEDWGQPKSRITHLIFCTTSGMDLPGADYQLTQILGLNPNVERVMLYQQGCFAGGTTLRLAKCLAESRKGARVLVVCAETTTVLFRAPSEEHQDDLVTQALFADGASAVIVGADPDEAADERASFVIVSTSQVLLPDSAGAIGGHVSEGGLLATLHRDVPQIVSKNVGKCLEEAFTPFGISDWNSIFWVPHPGGRAILDQVEERVGLKPEKLSVSRHVLAEYGNMSSVCVHFALDEMRKRSANEGKATTGEGLEWGVLFGFGPGLTVETVVLRSVPL
What are the official names of this protein?
Bibenzyl synthase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: ZN131_HUMAN
Sequence: MEAEETMECLQEFPEHHKMILDRLNEQREQDRFTDITLIVDGHHFKAHKAVLAACSKFFYKFFQEFTQEPLVEIEGVSKMAFRHLIEFTYTAKLMIQGEEEANDVWKAAEFLQMLEAIKALEVRNKENSAPLEENTTGKNEAKKRKIAETSNVITESLPSAESEPVEIEVEIAEGTIEVEDEGIETLEEVASAKQSVKYIQSTGSSDDSALALLADITSKYRQGDRKGQIKEDGCPSDPTSKQVEGIEIVELQLSHVKDLFHCEKCNRSFKLFYHFKEHMKSHSTESFKCEICNKRYLRESAWKQHLNCYHLEEGGVSKKQRTGKKIHVCQYCEKQFDHFGHFKEHLRKHTGEKPFECPNCHERFARNSTLKCHLTACQTGVGAKKGRKKLYECQVCNSVFNSWDQFKDHLVIHTGDKPNHCTLCDLWFMQGNELRRHLSDAHNISERLVTEEVLSVETRVQTEPVTSMTIIEQVGKVHVLPLLQVQVDSAQVTVEQVHPDLLQDSQVHDSHMSELPEQVQVSYLEVGRIQTEEGTEVHVEELHVERVNQMPVEVQTELLEADLDHVTPEIMNQEERESSQADAAEAAREDHEDAEDLETKPTVDSEAEKAENEDRTALPVLE
What is the function of this protein?
Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity).  May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
What are the official names of this protein?
Zinc finger protein 131.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Note=Sumoylation does not affect nuclear localization.
Protein: UBIG_YERPN
Sequence: MRAKTTSRHHNVDEQEIAKFEAVASRWWDLEGEFKPLHRINPLRLNYILQRSGGIFEKKVLDVGCGGGILAESMAREGAQVTGLDMGYEPLQVARLHALETGVKLEYVQETVENHAQQHPQHYDVVTCMEMLEHVPDPASVVRACAQLVKPGGHVFFSTINRNTKSWLMAVVGAEYLLKMVPKGTHDAKKFIRPSELIGWVDQTPLLERHIIGLHYNPITDHFKLGRNVDVNYMVHTQRDSE
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: CHMP6_DANRE
Sequence: MGNLFGKKKATRVTEQDRAVLQLKQQRDKLKQYQKRITLQMDKERQLAKQLLKDGKKDKALLLLKKKRYQDQLLEKTENQISNLERMVQDIEFAQIEMKVIEGLKVGNDCLKKMHEVLSIEEVEKIMDETHDAIEYQKQIDEMLAGSLTQEDEEAVLAELEAITQGEADLELPEVPGEELPEVPEQEPVREKERVKKKPEREMVAV
What is the function of this protein?
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.  MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.  In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity).
What are the official names of this protein?
Charged multivesicular body protein 6, Chromatin-modifying protein 6.
What is the protein family that this protein belongs to?
Belongs to the SNF7 family.
What are the subcellular locations of this protein?
Endomembrane system; Lipid-anchor. Late endosome membrane.
Protein: ISPG_AGRVS
Sequence: MAPAEDFDPKPRRASVAVDVGGVIVGGGAPVVVQSMTNTDTADIDGTVAQVAALHKAGSEIVRITVDRDESAAAVPKIRDRLERLGLDVPLIGDFHYIGHKLLADHPACAEALAKYRINPGNVGFKDKKDKQFADIIEMAIRYDKPVRIGVNWGSLDQELLTQLMDENQAKGFPLSARQVTREAICQSALLSAELAEEIGLSRNRIILSAKVSQVQDLIAVYSMLASRSDHALHLGLTEAGMGSKGIVASSAAMGYVLQQGIGDTIRVSLTPEPNGDRTREVQVAQELLQVMGFRQFIPVVAACPGCGRTTSTVFQELAQKIQSDIRKNMPVWREKYPGVEGLNVAVMGCIVNGPGESKHADIGISLPGTGENPAAPVFIDGEKALTLRGPKIAEDFEALVIDYIEKRYGQRSAAE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: CYB_CEPNI
Sequence: MTNIRKTHPLLKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTADTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYTYMETWNIGVILLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFIFPFIIAALAMVHLLFLHETGSNNPTGISSDADKIPFHPYYTIKDILGALLLILVLMTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLILMPLLHTSKQRSMMFRPISQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLLILVLMPMASTIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FAR1_ACAVI
Sequence: MYHQLILMALIGVIMANVVPFSMSNIPEEYKEFIPEEVKNFYKNLTQEDRQILRELASKHATFTNEDAALEALKNKSDKLYQKAVELRNFVKAKIDSLKPDAKAFVDEIIAKVRSLRPEDGQKLDVEKLKQAARDIIAKYEALNEETKEELKAPFPNTTKIITNEKFTRIANSFLQKN
What is the function of this protein?
Binds retinol and different fatty acids.
What are the official names of this protein?
Fatty-acid and retinol-binding protein 1, Av-FAR-1, Av20.
What is the protein family that this protein belongs to?
Belongs to the fatty-acid and retinol-binding protein (FARBP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HDT4_ARATH
Sequence: MEFWGIEIKPGKPFKVIQKDGFMVHASQVTLGDVEKVKKDETFAVYVKIGDDENGFMIGNLSQKFPQFSIDLYLGHEFEISHNSTSSVYLIGYRTFDAFDELDEEIDSDSELDEYMEQQIAALPQNEINPEEDDESDSDEMGLDEDDDSSDEEDVEAEAPLKVAPPSKKMPNGAFEIAKGGKKNKSSGGKKRCPFPCGPSCKK
What is the function of this protein?
Probably mediates the deacetylation of lysine residues lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
What are the official names of this protein?
Histone deacetylase HDT4, HD-tuins protein 4, Histone deacetylase 2d.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase HD2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: GPMI_SHEHH
Sequence: MMTRKRPLALLILDGWGYRENTQKNAVFHANTPVLDQLTAKYPNSLISGSGIDVGLPDGQMGNSEVGHINIGSGRIVYQELTRISKAIDDGEFDTNPTLIKAIDDAIKADAAVHIMGLLSPGGVHSHQDHIEAMCRLSVKRGAKKVYLHAFLDGRDTPPRSAKPGLAHFEELFKTLGTGQVASLIGRYYAMDRDNRWDRVSQAYELITEGKGLHQATSAVEGIEAAYTRDENDEFVGSTAIPDAQGNIIKLEDNDALIFMNFRADRARQITRSFINADFDGFKRAVTPKINFVMLTEYAADIKAAIAYPSSDLVNTLGETLQNRDLTQLRISETEKYAHVTFFFNGGKEEPFKGEDRILVQSPKVATYDLQPEMSSVELTDKLVEAIESTQYDVIICNYPNGDMVGHTGNFDAAVKACEAVDSCIGRIVEALEKVGGECLITADHGNAEQMTDESTGQAHTAHTSELVPLIYVGRDAEIEKGGRLSDLAPTMLTLMGQEVPAEMTGRSIIQLKE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: FER_APHSA
Sequence: MASYKVTLKTPDGDNVITVPDDEYILDVAEEEGLDLPYSCRAGACSTCAGKLVSGPAPDEDQSFLDDDQIQAGYILTCVAYPTGDCVIETHKEEALY
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin-1, Ferredoxin I.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
Protein: CLPP_PSEPF
Sequence: MFRNSYIQQNSDIQAAGGLVPMVVEQSARGERAYDIYSRLLKERVIFLVGPVEDYMANLICAQLLFLEAENPDKDIHLYINSPGGSVTAGMSIYDTMQFIKPNVSTTCIGQACSMGAFLLTAGAPGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAKEILFIRERLNTLMAKHSGRTLEEIERDTNRDNFMSAEAAKEYGLIDEVINQRPA
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_FLAJ1
Sequence: MAKENFNRSKPHLNIGTIGHVDHGKTTLTAAITKVLSDAGYCQAKSFDQIDNAPEEKERGITINTSHVEYETANRHYAHVDCPGHADYVKNMVTGAAQMDGAILVVAATDGPMPQTREHILLGRQVGIPRIVVFMNKVDMVDDAELLELVEMEIRDLLSFYEYDGDNGPVVQGSALGGLNNDPNWVPKIIELMEAVDNWIEEPVRDVAKPFLMPVEDVFTITGRGTVATGRIETGVANTGDPVEIIGMGAEKLTSTITGVEMFRKILDRGEAGDNVGLLLRGIDKADIKRGMVIIKPGSVKPHAKFKAEVYILKKEEGGRHTPFHNNYRPQFYVRTTDVTGVISLPAGVEMVMPGDNLTIEVALLSPIAMNVGLRFAIREGGRTVGAGQVTEIVE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHP6_CANAL
Sequence: MAPGERKKSSRKKKDPDAPKRSLSAYMFFANENRDIVRAENPGISFGQVGKLLGEKWKALNSEDKLPYENKAEADKKRYEKEKAEYAKKNSA
What is the function of this protein?
DNA-binding protein that induces severe bending of DNA.  Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).
What are the official names of this protein?
Non-histone chromosomal protein 6.
What is the protein family that this protein belongs to?
Belongs to the NHP6 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RIMO_SYNC1
Sequence: MKESDSVEKRKVSMISLGCAKNLVDAEVMLGYLPQDRFEITTDEAQADIIIVNTCGFISDAKEESVETLLEAIEYKKSGNCTLLVVTGCLSQRYAEDMAKELPEVDILLGTGDVPRILELIEAHDRGEDVRQSVGLPQYLYDHTTPRVASSPFYSTYVKIAEGCNNLCSYCIIPQLRGPLRSRSIASVVAEVERLVAAGAQEVNLIAQDITAFGADRHDGASLEGLLRELVKISELRWLRLLYAYPDGISDELIELVATEEKICSYFDVPLQHIDDRVLARMNRRVGEDTIRDLIHRMRQRIPDLTLRTSFIVGFPGETDAEFAKLLAFVEEGHFDRVGVFRYSREEDTPAASLPDQVPEGVKKSRYNKLMKAQQRVSFRRNRALIGRVEPVLVEGYSEETELLLSGRSIRQAPDVDGQVYITAGQADVGQIVPLRITDSSEYDLIGEIVDESDE
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_BARHE
Sequence: MKYNREKLKNKVCLAIIGMPHGIKGDVLLKILSSEPQRLKTYGTLYDDRGHSYEIVMLRMQKKNAIVHFKGVEDRSAAEALRGIHLYVARDQLVDDLTEDEFYQVDLIGLRVQDCTGRILGEVSGLFNFGAGDLLEMRLNTGKTVLIPFSKAAVLEVCIASGFLVVDPVAAGLSDGGENT
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYPH_ECOSM
Sequence: MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAAIKLADKAPESTPTVYRRISE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: AROC_SYNAS
Sequence: MSGNTIGNVFRVTTWGESHGGAIGAVIDGCPPGLGLSEQHIQAALDRRKPGVGAFATPRQETDRIEILSGVFEGRTTGTPIALLIRNRDANSGAYDGLRNIFRPGHGDYTYFKKYGLRDHRGGGRASGRETAARVAAGAVAALVTAAAGIDVLAYTIALGGVSISESGTTVNRESLANPLCCPDQEAARRMTGRLEEARNAGDSLGGIVGIVVRGCPAGLGEPVFDKMDAQLAGALMSIGTVKGVEIGAGFAVAGMKGSESNDPLSPGGFLANASGGILAGITNGEQINMRVACKPIPSISRSQKTVDREGNPVTLSIGGRHDVCVIPRIIPVCEAMVQIVLADFLLRQKAVTL
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: WAP_PIG
Sequence: MRFLTSLALALIALEAALALAPALNLPGLATCPELSSSSEDPCVISCVNDESCPQGTKCCARSPCSRSCTVPLLVPVPKAGRCPWVPAPLAPELCLEKNECSRDDQCRGNKKCCFSSCAMRCLDPDTEAPLQ
What is the function of this protein?
Could be a protease inhibitor.  May play an important role in mammary gland development and tissue remodeling.
What are the official names of this protein?
Whey acidic protein, WAP.
What are the subcellular locations of this protein?
Secreted.
Protein: DNS2A_RAT
Sequence: MAAPSSLLLAALLWVPAEALSCYGDSGRPVDWFVVYKLPANSGSGDKPWKGLMYKYMDQNSEGWQDGVGHIDSKDGAVGLTLQPLYQKNSSQLAFLLYNDQPPKSSSAQDSSSRGHTKGVLLLDQEGGFWLVHSVPRFPSPASSGAYSWPPNARTYGQTLLCVSLPFSQFPGIGKQLTYTYPLVYDHKLEGIFAQKLPDLEEVTKGHHVLREPWNSSVILTSRAGTTFQSFAKFGKFGDDLYSGWLAAALGTNLQVQFWPNSPGILPSNCSGTHKILDVTETGFPGPSGPTFNATEDHSKWCVAPEGPWVCVGDMNRNKRETHRGGGTLCTQVPALWKAFRSLVKACKPC
What is the function of this protein?
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA.  Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation.  Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
What are the official names of this protein?
Deoxyribonuclease-2-alpha, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II.
What is the protein family that this protein belongs to?
Belongs to the DNase II family.
What are the subcellular locations of this protein?
Lysosome.
Protein: RHG29_MOUSE
Sequence: MIAHKQKKAKKKRVWASGQPSAAITTSEMGLKSVSSSSSFDPEYIKELVNDVRKFSHMLLYLKEAILSDCFKEVIHIRLDELLRVLKSILSKHQNLSSVDLQSAAEVLTAKVKAVNFTEVNEENKNDIFREVFSSIETLAFTFGNILTNFLMGDVGSDSILRLPISRESKSFENISVDSVDLPHEKGNFSPIELDNLLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNIVKLAEATRSSIGIQEFMPLQSLFTNALLSDIHSSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKDLWKQQQNKLLETETALKKAKLLCMQRQDEYEKAKSSMFRAEEEQLSSSVGLAKNLNKQLEKRRRLEEEALQKVEEANEHYKVCVTNVEERRNDLENTKREILTQLRTLVFQCDLTLKAVTVNLFHMQQLQAASLANSLQSLCDSAKLYDPGQEYSEFVKATSSSELEEKVDGNVNKQMTNSPQTSGYEPADSLEDVARLPDSCHKLEEDRCSNSADMTGPSFVRSWKFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSEAGPNSLGAFKKTLMSKAALTHKFRKLRSPTKCRDCDGIVMFPGVECEECLLVCHRKCLENLVIICGHQKLQGKMHIFGAEFIQVAKKEPDGIPFVLKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSPEDKKHPHVSIEVNRILLKSKDLLRQLPASHFNSLHYLIAHLRRVVDHAEENKMNSKNLGVIFGPTLIRPRPTTAPVTISSLAEYSNQARLVEFLITYSQKIFDGSLQPQAVVISNTGAVAPQVDQGYLPKPLLSPDERDTDHSMKPLFFSSKEDIRSSDCESKSFELTTSFEESERRQNALGKCDAPLLDNKVHLLFDQEHESASQKMEDVCKSPKLLLLKSNRAANSVQRHTPRTKMRPVSLPVDRLLLLASSPTERSSRDVGNVDSDKFGKNPAFEGLHRKDNSNTTRSKVNGFDQQNVQKSWDTQYVRNNFTAKTTMIVPSAYPEKGLTVNTGNNRDHPGSKAHAEPARAAGDVSERRSSDSCPATAVRAPRTLQPQHWTTFYKPPNPTFSVRGTEEKTALPSIAVPPVLVHAPQIHVTKSDPDSEATLACPVQTSGQPKESSEEPALPEGTPTCQRPRLKRMQQFEDLEDEIPQFV
What is the function of this protein?
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.  Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42.  May act as a specific effector of RAP2A to regulate Rho (By similarity).  In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
What are the official names of this protein?
Rho GTPase-activating protein 29, Rho-type GTPase-activating protein 29.
Protein: IF2_BUCBP
Sequence: MEMINIQDLANEVDMSVDRLVQVCIKIGILKTKYDTITQLEKLTILNYLNENLKNSNKNVLMLKRKIRSTVKIFSSGGKNKCISIEIRKNKRYSKSNDDIKTFLEKNKDINLNKSEIVLSAKEDSKIFVSHSKDNINSNINDTCTIRKKFNKNFKKQQKINILSEKEDKNNLDNVLNVEQGSKKKINFKNVVLEEKKENKVKFSNYIKLSEKYNTRKVSNFLTSKNIRDHNNVEKHRRNRNKILRNKHQKDNFSFEKNLSDKNIKLDNCIHKKSIKNKKESLLKQVFKKPLRAINRNIILSSAISIFNLANKMAVKSSEIIKMMARLGYTVTINQIIDQDIAQLVAEEMGHKVTICYENKLEDKIMRDRDFGDGIKKTRPPIITIMGHVDHGKTSLLDKIRLTRVADSEPGRITQHIGAYHIKINNKIITFLDTPGHSAFTAMRARGAQVTDIVILVIAIDDGIKPQTIEAIQHAQAASVPIIIAINKIDKLITNIEKIKNELTKYNILPEEWGGDNIFVNISAKSGEGIESLLNAILTQSEMLELKSISNGMASGLVIESYLDKGRGPTAIILIKEGKLNKGDIVLCGFEYGKVRSIRDDLENEVNSIGPSIPVKILGLSGIPLAGDKIVVVRDEKQAREVATYRQKKFKEQKMSKQRQLKSLDIFEDVKRSSNPSLNIVIKSDVQGSLEAISYSLLKLSNDEIKINIIGKGVGGITETDVLLAAASNAIIIGFNVRADSSAKRIIEFENVDFRYYSVIYQIIDEIKNCICGMLSPKYQQKIIGLANVRSIFKSPKIGVIAGCIVMEGIIKRNSIIQILRNNVVIHKGELISLRRFKEDVSEVRCGVECGIGMKNFNDICIEDIIEVFETIEIKQ
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXP33_ORYSJ
Sequence: MAMPVVQVLLLCALAYQAVDAQWTPATATFYGGSDGAGTMGGACGYGNLYNAGYGLNNAALSSALFNDGAMCGACYTIACDTSQSTWCKPGTSITITATNLCPPNYAKKSDAGGWCNPPRKHFDMSQPAWTSIAIYQAGIVPVNFKRVPCQKSGGIRFTISGRDYFELVTVFNVGGSGVVAQVSIKGSKTDWMAMSRNWGQNWQSNAYLNTQSLSFKVKLDDAREVTVWNIAPSNWNFGTTYTSNINF
What is the function of this protein?
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans.  No enzymatic activity has been found.  May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
What are the official names of this protein?
Expansin-A33, Alpha-expansin-33, OsEXP33, OsEXPA33.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.