PharMolix/UniProtQA huggingface dataset:
Protein: FSLM_DICDI
Sequence: MKSIFIIIFILYVFQVNSQTIYPIDPSGKCEQYIGDTPSSPCSKFLNNLDSIYVSSNATQQNAMKKLDEYFGILGAIGTSGCKSDSLTYKTLCSIYLPGCESFTNNQTNITIAIPKRICYNTCNNVTTKCGVPKFYFSCDQIEPVSGLPMFPLNYSEFNLTNYDVGNPNYTVQCYGPLSDNTMVNLDSSYCPPPLFYHNSTDHDADYDRGYLFVSETSNCVVPNPVPLYTNEQWDQLYNLSNTLAVLSTFGSLYLLVTFIILNPKVTSFDRMYGFFNGSVFMMSLSGVILFIAGGPRALIKDGGARISVFEDPLCSSTGFIFQLFAINAILFWAYMGFDLWWRVKYITKPLNIQKYYVPIAFTISFIFSVIPLATKNYRMVRGNIHCWVHKAVLQNTLFFGPLGLTLTISTGFIGLVIYEIYKIVKATGRGGIMKLEIKPILNIVLIYFSFVYIFAFNFHNDNNSKNTYGSIDEFFQCTLESDDPSKCTVGGPSIGSLGYFIYCIRIYGIYCFFLQGLNERAFKIWKRSIVFNNRFILFIKVKLFSMDNNSPSESGNSSTTAGTSTTINNSNINKKNNNSKPTLSTMDSNAFSKNNDSDSDFDDYDPYHKKQNDIEIGSVNIK
What are the official names of this protein?
Frizzled and smoothened-like protein M.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MS84A_DROME
Sequence: MYMYVNPNYVLVGGPCCGPCGGCGPCGGCGPCCGGCGPCCGPCGGCGPCCGGTSSFCGCGPCC
What are the official names of this protein?
Male-specific sperm protein Mst84Da.
What is the protein family that this protein belongs to?
Belongs to the MST(3)CGP family.
Protein: PYRC_PSEE4
Sequence: MSDRLTLLRPDDWHIHLRDGAVLQHTVGDVARTFARAIIMPNLVPPVRNALEAGGYRERILAARPAGSRFEPLMVLYLTDRTSPEDIRAAKASGFVYAAKLYPAGATTNSDSGVTSIDNIFPAIEALAETGMPLLVHGEVTRSEIDVFDREKRFIDEHMRRLVERFPTLKVVFEHITTADAAQFVTEAPANVGATITAQHLLYNRNHMLVGGIRPHFYCLPILKRNTHQVALLDAATSGNPKFFLGTDSAPHAKHAKEAACGCAGCYTAYAAIELYAEAFEQRNALDKLEGFASKHGPDFYGLPRNTDTITLVRDEWTAPDSLPFGDNTVIPLRAGEKLRWRLLEDNA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: MURC_XYLFM
Sequence: MIRRLQDNGDLIRAFPRVHFVGIGGAGMTGIAEVMLTLGYEVSGSDNADNVATRRLATLGARVMRGHSAANVLGTDCVVVSSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRHGIAVAGTHGKTTTTSLIAAVLSEGGLDPTFVIGGQLLAAGANAKLGAGQWLVVEADESDGSFLRLNPLVAVVTNIDADHLENYGNDFSRIKDAFTEFLQRLPFYGLALLCLDDPEVAELAGKARRHVMTYGIDAAADVRAEDVVQDGARMYFTLCLPEGKVIPVTLALPGRHNVLNALAASAVGWQLGVPPEVIGRALKSFVGIGRRFNDLGDVAIGNGACVRLIDDYGHHPRELEAVFAAARGGWPDKRLVVAFQPHRYSRTRDQFDAFAAVLSSVDALVLSEVYPAGEVPIPGADAKALARAIRARGRSEPVVVGQVASLIEVLPDVLQEGDLLLMMGAGDIGSIAQRIVHDGFVFGEV
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAD56_ORYSI
Sequence: MVRGRTELKRIENPTSRQVTFSKRRNGLLKKAFELSVLCDAEVALIVFSPRGRLYEFASAPSLQKTIDRYKAYTKDHVNNKTIQQDIQQVKDDTLGLAKKLEALDESRRKILGENLEGCSIEELRGLEMKLEKSLHNIRLKKTELLERQIAKLKEKERTLLKDNENLRGKHRNLEAAALVANHMTTTTAPAAWPRDVPMTSSTAGAADAMDVETDLYIGLPGTERSSNRSETG
What is the function of this protein?
Probable transcription factor.
What are the official names of this protein?
MADS-box transcription factor 56, FDRMADS8, OsMADS56, RMADS214.
What are the subcellular locations of this protein?
Nucleus.
Protein: CARB_METMJ
Sequence: MPKKSHIKKVLIIGSGPIQIGQAAEFDFSGSQACRALREEGVEVVLVNSNPATIQTDPDTADVIYIEPLKAELIAKIIAKEKPDGILSGMGGQTGLNMTAELAEMGALEGVEILGTPLEAIYRGEDREQFRDLMNAIGEPVPRSMILEHMNQIDEAIREVGLPAIIRPAYTLGGSGGGVAHTPEEMRRICELGLARSRIHQVLVEESVAGWKEIEFEVMRDAADTCIIVCGMENVDPMGIHTGESVVVAPILTLRDDEFQTLRTAAIKIIRALDVQGGCNIQFAYKDGDYRIIEVNPRVSRSSALASKATGYPIARVAAKIAIGLRLDEIMNTVTGVTPASFEPAIDYVVVKVPRWPFDKFKSADRTLTTAMKSTGEVMAIGRTVEEAFKKALRSLDNDMQQHTNPSEIRMILTSPTDERFGCLFDAFREGFTVREIAELTAITPFFLEKIKNIVDLERKLETDFEPEDVRVARRSGFSDEDLLALTKKTAGEIEALGGTPTYKMVDTCAAEFPATTPYFYSTWEEGCELVRDSAKKVLILGSGPIRIGQGIEFDYCTVHAVMALREEEGIEVHIVNNNPETVSTDADTSDRLFFEPMQLEDVMNILKKDDYYGVMVQFGGQNSVNLAVPLEAEIRRLDLPTKILGTSPDAMDAAEDRDRFSRLLTRLEIPSPANSSAYSEEEAREMAGEIGYPVLVRPSYVLGGRAMELVHDEAELESYIKEAVRVSRKHPVLIDSFLQNAVEIDVDAVSDGTDVLIGGIMEHIEWAGVHSGDSACVIPPQSLTPSVIARVRDYTKKIALGLGVVGLINIQYAVRNDVVYVLEANPRASRTVPFVAKATGIALAKIAAKVMVGRKLADMGVAEPEIEHVAVKEVLLPFNKLPGVDTVLGPEMKSTGEVMGIDYDFGRAYYKACTAADNTLPTTGNVFISVTDEQKEELLPVARKLRELGLSLYGTSGTVDFLTQNGVEANLVRKVQEGSPNVIDAMRSGSIRLIINTPADKASRQDHIQIMRAAVDYGIPYITTLQAARAAAMAIDAIKREEITIEPLGHYHGLM
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: MYO9_ARATH
Sequence: MVRECFTFLNIFVLHSIGSHVWFEDPEVAWIDGEVEKINGQEVVIQATTGKKVTAKLSKIYPKDVEAPAGGVDDMTKLSYLHEPGVLQNLKIRYELNEIYTYTGNILIAINPFQRLPHIYDAHMMQQYKGAPLGELSPHVFAVADVAYRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRAVTEGRTVEQQVLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDKQGRISGAAIRTYLLERSRVCQISDPERNYHCFYLLCAAPQEEIEKYKLGHPKTFHYLNQSKCFELVGISDAHDYLATRRAMDIVGISEKEQEAIFRVVAAILHIGNIDFTKGKEVDSSVPKDEKSKFHLKTAAELLMCDLKALEDALCKRVMITPEEVIKRSLDPQSAVTSRDGLAKTVYSRLFDWLVDKINKSIGQDANSRSLIGVLDIYGFESFKTNSFEQFCINFTNEKLQQHFNQHVFKMEQEEYTKEAIDWSYIEFVDNQDVLDLIEKKPGGIVALLDEACMFPKSTHETFANKLYQTFKTHKRFIKPKLSRTDFAVAHYAGEVLYQSELFLDKNKDYVIPEHQDLLGASKCPFVVGLFPPLPEETSKSSKFSSIGSRFKLQLQQLMETLNCTEPHYIRCVKPNNLLKPAIFENVNIMQQLRCGGVLEAIRISCAGYPTRKPFFEFINRFGLLSPAALEGNFDEKVACQKILDNMGLKGYQIGKTKVFLRAGQMAELDARRAEVLSSAAKKIQRRIRTHQAQKRFIVLRKATISLQAICRGRLSCKHYDNLRREAAAVKIQKNGRRHYSRKSYKKLHVASLVVQTGLRAMAARKQFRFRKQTKAATIVQAQWRCHRAISYYKKLKNGVVLSQTRWRGRLAKRELRKLKMAARETGALKEAKDMLEKKVEELTYRVQLEKRSRGDLEEAKTQEILKLKSSFEEMRKKVDETNALLLKEREAAKKAAEEAPPVIKETQILVEDTKKIELMTEELESVKVTLENEKQRADDAVRKFEEAQESLEDKKKKLEETEKKGQQLQESLTRMEEKCSNLESENKVLRQQAVSMAPNKFLSGRSRSILQRGSESGHLAVDARSNLDLHSHSINHRDPSEVEDKPQKSLNEKQQENQDLLIRSIVQHLGFQGNRPITACIIYKCLLQWRSFEVERTSVFDRIIQTIGHAIETQDNNNTLAYWLSNTSTLLLLLQRTLKASGAAGMAPQRRRSSSATLFGRMSQSFRGAPPGVNLAMINGAAGGGADTFRQVEAKYPALLFKQQLTAYVEKIYGMIRDNLKKEISPLLGLCIQAPRTSRASLVKGASRSVGNTAAQQALIAHWQGIVKSLTNFLNTLKSNNVPSFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEYVKAGLSELEHWCFKATNEYAGSSWDELKHIRQAIGFLVVHQKPKKTLDEISHDLCPVLSIQQLYRISTMYWDDKYGTHSVSPDVIANMRVLMTEDSNNAVSNSFLLDDDSSIPFSVDDLSKSMEKFEIADIEPPPLIRENSGFSFLLPVSE
What is the function of this protein?
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation.  Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables.  Involved in trafficking of Golgi stacks and mitochondria.
What are the official names of this protein?
Myosin-9, Myosin XI C, AtXIC.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Plant myosin class XI subfamily.
Protein: CYAY_PSEP1
Sequence: MSLSEARFHDLVDATQQALEDLFDESGLDLDMENSAGVLTVKFEGGAQLIFSRQEPLRQLWLADRSGGFHFDYDEDSGKWVCEKSEELLGEMLERIVWERAGEKLDFDEI
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: CASP3_HUMAN
Sequence: MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
What is the function of this protein?
Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed:7596430, PubMed:18723680, PubMed:20566630, PubMed:23650375, PubMed:35338844, PubMed:35446120).  Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed:7596430, PubMed:18723680, PubMed:20566630, PubMed:23650375).  At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond (PubMed:7774019, PubMed:7596430, PubMed:10497198, PubMed:16374543).  Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain (By similarity).  Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430).  Involved in the cleavage of huntingtin (PubMed:8696339).  Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690).  Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800).  Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed:30878284).  Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed:35446120, PubMed:35338844).  Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486).
What are the official names of this protein?
Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WCAC_ECOLI
Sequence: MNILQFNVRLAEGGAAGVALDLHQRALQQGLASHFVYGYGKGGKESVSHQNYPQVIKHTPRMTAMANIALFRLFNRDLFGNFNELYRTITRTAGPVVLHFHVLHSYWLNLKSVVRFCEKVKNHKPDVTLVWTLHDHWSVTGRCAFTDGCEGWKTGCQKCPTLNNYPPVKIDRAHQLVAGKRQLFREMLALGCQFISPSQHVADAFNSLYGPGRCRIINNGIDMATEAILADLPPVRETQGKPKIAVVAHDLRYDGKTNQQLVREMMALGDKIELHTFGKFSPFTAGNVVNHGFETDKRKLMSALNQMDALVFSSRVDNYPLILCEALSIGVPVIATHSDAAREVLQKSGGKTVSEEEVLQLVQLSKPEIAQAIFGTTLAEFSQRSRAAYSGQQMLEEYVNFYQNL
What are the official names of this protein?
Putative colanic acid biosynthesis glycosyl transferase WcaC.
Protein: HIS5_METCA
Sequence: MSSVAVIDYGMGNLHSIAKALQHADANAAVTVTSDPDVILASDRVVFPGVGAMRDCMAHLAERRLEQVVRRAAAEKPFLGICLGMQALLEESEENGGTRCLGLITGRVLRFPEGLTGAAGEPLKIPHMGWNRVHFSDPSHPLWAGIPAESWFYFVHSYYAAPADPADVAATSDYPTPFAAAVARGKVFAVQFHPEKSQAAGLRLLANFLRWEPWSSR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REP_AHEBV
Sequence: MFLAAIHVITFFISENSKSFYTMSTPTSAFNAMLDDIGIEIQDDISALCSTLADPSDAEPAPPVHDVDDLLASVGPDKRKKIRSGLLTIHPPSSHPSWLKPETWFPQCDDILEIWCAKFEKGEDTGNLHVHIYFKLKHSNTIRFELLQKWITKHVTGFDFKPQRSATKNSTQCVVNYVLKPETSVGDPFIWNASCAFDQKTWDARHKGKGKKQEIIDHIMARDWTLSWASLVHESDESRALLADCGWGKRFQEDRAAAQPRRKIKDVVILYGAAGTGKTTMAMDWDSKPDETTKARYYRRSCDEDFWGGGATAYNGQRVIHYDEFGGQEKFASLKEITSIGLPGPPVKVKGSGRDLNHDTVVFTSNVHPAGWYKGVWAKDPHQFKPFQRRVTKVLFFPRERPDGTENVPSDGNPAHFVDQTPEWVAFGDNLDLAIEHAESCWPLPATIEDDGGGAFAPGFSLTSEPEPKRRRFF
What is the function of this protein?
Plays an essential for the replication of viral DNA.  Presumably cleaves viral genomic dsRNA replicative form to initiate rolling circle replication.
What are the official names of this protein?
Replication-associated protein, Rep.
What are the subcellular locations of this protein?
Host nucleus.
Protein: Y047_SIFVH
Sequence: MKIVTYVTTSNKNVKPKWADLVFSIPQVDLKTALVTVAHINDDVLLLRNDVNVLNKDVIVRFFKSFKTSAVVKYGNEVIGYYLTRADKSSRMTPTLTVTHYALKV
What are the official names of this protein?
Uncharacterized protein 47.
Protein: NEEDL_BPKVM
Sequence: MFMGLDGFEWWTGVVEDRTTDPLKLGRIKVRMIGLHPDKKSSEQGIRTEELLWVHPMQSLDNAAMNGIGNAPIGVVEGTWVFGFFRDKLRQDAVAMGVLPGIPEDLPNGSVGFNDPNEKYPLADKLNEPDTNRLARNDVDPDVYDESQSQTAFDNGEAPYVYRPHPIIASKRAAEEKEIPLAGYNAEGPKYDEKGTPYAAQYPYNHVRESESGHIHEIDDTEGAERLHTYHRTGTFEEIHPDGSRVTKIIGDDFEIVHKNQNVYIKGNLNITVVGDATFYCQQNVTQQIDGDLKQHVKGNVDQHVEMNVTQTVDKDVTQVVHQNVTQTVDMNVTQTVHQNVTQTVDGDVNQTVGGNVQSNVTGDYTQNISGNYTITVGGSMSESVSSSYTRSAASISDDGGGATLNLAGSAALDGTTVSLG
What is the function of this protein?
Tail-associated protein of the baseplate hub that is essential for viral DNA ejection.  Involved in the tail assembly.
What are the official names of this protein?
Protein Gp5.
What are the subcellular locations of this protein?
Virion. Note=Present in 3 copies in the baseplate.
Protein: MALE_PYRAB
Sequence: MKRGIYAVLLVGVLIFSVVASGCIGGTQTQTETQTPEKTQTPTTTQPSPTTTTSPTQTTSQTPTETETHTQEAECGSGKVVIWHNMQPNELQVFQSLAEEYMAMCPDVEIVFEQKPDLENALKVAIPAGQGPDLFIWAHDWIGKFAEAGLLEPIDEYITDDLLQKFAPMAREAIEYKGHYYALPFAAETVAMIYNKKIVSEPPKTFDELKEVMEKYYDPNNEKYGIAWPINAYFISAIAQAFGGYYFDDKTEQPGLDKPETIEGFKFFFENIWPYMAPTADYNTQQSIFLEGRAPIMVNGPWSIGSVKDAGIDFGVAPLPPIIKDGKEYWPRPYGGVKLIYFAAGTHNKDAAWKFVKWFTTNPEVIKQLALDLGYIPVLSEVLNDPEIKNDPVIYGFGQAVQHAYLMPKSPKMGAVWGGVQGAIDEILKDPKHADIEAILKKYQEEILKNMQG
What is the function of this protein?
Involved in an abc transport system for maltotriose.
What are the official names of this protein?
Maltotriose-binding protein, MMBP, Maltodextrin-binding protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
Protein: ATPA_BACCR
Sequence: MKHMSIRAEEISALIKQQIENYQSEIEVSDVGTVIQVGDGIARAHGLDNVMAGELVEFSNGVMGLAQNLEENNVGIIILGPYTEIREGDEVRRTGRIMQVPVGKELIGRVVNPLGQPVDGLGPINTTNTRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTAVALDTIINQKDEDMICIYVAIGQKESTVRNVVETLRKHGALEYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFIETQAGDVSAYIPTNVISITDGQIFLQSDLFFSGVRPAIDAGTSVSRVGGSAQIKAMSKVSGTLRLDLASYRELEAFAQFGSDLDKATQAKLNRGARTVEVLKQGLHKPLRVEKQVIILYALTRGFLDDIPVVDITRFEEEFHAWLDSNATDLLEEIRTTKKLADDDKFAAAINGFKKVFVASE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TAGA_VIBC3
Sequence: MVVRYSLLMKVSFAILIFLVGCNENATSSNDQYLTDPDISEQTKKPSRPIIDEKNKGVTDTSVTIEWDKIECEKNFSHYNVIVYRKDRIEDVITIRTRNNSVFIDDLKPNSQYSIDVSSCLHSACSESAKIEFITLNEIDYYHTTEIEKNVYGSLEGEVRFVQTHVISPEGRKNEPEIITGRDALILFKPSIKNSSSILMKIYSEDGLTSKVVMKSPSMLPKTDQPIDIDENNKVVSYSNSYWSAEIPWNKMKSGMSLHFEDENGNLGIIESERIKFSAPSELIIQNIDLGMLYKPRGRNIVIKELERTAVDYFQKVPVSKLIFSDYTPIHFEKITLPNGSVYTEKSADIGGWHQGDMREAVGKALVSTGINNANLGIVASSGYSQQYNRLTNHITAHTNIGYYNNGVVVHGGSGGGGIVTLENTLHNEWSHELGHNYGLGHYVAGGTSHGPDTSWGWDGYYKRFIANFDWKRSPQSNIRPDNQEVVKPFMDKYTYLWDAMSGGYDHQNGIISRYTLHHPYVARIIQDWLKNGAVVINNDYMVWDELKNIYVYKGTNFKVPIKKGVPVVTILGVYDPDKINPSQLYPPTYSNYGNIFDLEKPRSESSLKGWQYVKDVNYLDRVNTHWHTMLVNRKEEKICRFSYLSPKGKKFEFLGYEDIENKICTGSRSIHYLEDGKKNPIESKYNDYFLLSIDGDGEISYVPDSTIGESKICSLKMSGTVYGAGFIKGNSCRQIDGVFMNGFQWAFTLNQSGVNSTYTWSNECVLKIKDKDNNIESISIPNYRIEKNQSNKIHLNISREKPIIDINVYCGEHELTSIKVSDNPDIKLLKGPIIVGQEHGYTSYEPKLPSGWFKHYDNFEPKNEINHELGKMRVNDNDEYICRFNFSDSDREMKFVGYVSQLSESKYICTGGSEIYYKKNDINIELSSKENDFEWLSVRDKNLIGSKIEFDNNKTLCVLDNRSFYGAGYLDENNRCTQDRQIHWSNGKQWLFSTYKTMTYH
What are the official names of this protein?
ToxR-activated gene A lipoprotein.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: RL18_BIFLO
Sequence: MSVAILGKGKKVALKRRHARIRKRISGTPERPRLVVTRSNRHMVAQVVDDTKGITLVSASTLQADFAGFEGTKTEAAKKVGELIAEKAKAAGITAVVFDRGGNKYTGRVAAVADGAREGGLAL
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PTH_PSE14
Sequence: MTAIQLIVGLGNPGAEYEQTRHNAGAFFVERIAAAQRVNLVPERKFFGLTGRFTHQGQDVRLLIPTTYMNRSGQAVAALAGFYRIPVESILVAHDELDLPPGVAKLKVGGGHGGHNGLRDIIAQLGNQNTFHRLRLGIGHPGDASKVSGFVLGRAPRAEQEKLDASIDFALGVLPDIFAGEWNRAMKNLHSQKA
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RGYR1_SACS2
Sequence: MTSINKVPPSIYTRSCPNCGGNISSQRLFNGSVCESCLKDDREFSNLSDLINILSENSNLKNLTQIRDVLEEYKKVEEIFGKLLNNSKPIGPQRSWTIRFLRGESFAIIAPPGLGKTTFGLIMSLYNATRNRKSIIIFPTRTLISQTVDKLAKFSELYSYSPRILYNKQSPTQTENILDQLKSGNFDIFISTNRFVIQNLSELSNIKFDFIFVDDVDAALKSGKSAKAILRLVGFTDEDIQTTMKLLRENIGEEEKFGKIQEIRESRLKDKIVIFSSATISRGNPILSSLMGFRPGSSVIYLRNIYDSYIDLTQTCKGQDFEECTLGTVIKLLKRLNDGTLIFVPIDKGAQYADYLASNLRDHGINVESVASSSISKLEKFERGEVSSLVGVATHYGVLVRGIDLPWRVKYSIFVGIPKFKFKIGEYMHPLALTRLLSLVYLVKNDDKVRGLLSYIRKRLRKISPAALAMLAKDIREGKIDDERLKEAYNLVNEYLKDNEFLKKVSDVGDLVIEGDYILMPDYLTYIQASGRTSRLYGANLTTGLSVLLIDNSRLFELLNKKLNLILDEVKWYSLDIDADKLGQVSLSDISAKITEERESLSKIKKEGNVESSSLSVKTTLFIVESPNKAKTISNFFSRPSTRSYGKLRVYETVLGDRVLIVAASGGHIYDLITEDESEKQDDNYVYGVLVKDSKFIPIYSTIKKCEKGHQIVKDLSQNKCPICGSRIVTDKTEVVDILRKLALEVDEVLIGTDPDTEGEKIAWDIYLAIRPFNGNIKRAEFHEVTRRAILNAIKNPREFNDNLVKSQIVRRIEDRWIGFKLSRKLQTEFWEQHCTSISKKNSKDEECKENRNLSAGRVQTPVLDWVVNRYQKYNENKKKYLIIESQDKSIFPFSVLALKKNGLSKNTQIIIHLEDINIKEEEFGPLPPYTTDTLLSDAANLLRIPASDTMRVAQDLFELGLITYHRTDSTRVSNVGISVAETYLKSKQVDISKIFRPRSWGEGGAHEAIRPTKPLDETMLKASIEQGDLELSKQLTFNHFRVYNLIFRRFITSQLPPLVVTKQIVRIRAYTKDNIELELDENKKEFVIGYKLKEGDEFRQTLQDAIYTLFRLYQPLDEKMKGKELSATITGTLNKSDVQLYTEGELISEMKSKQIGRPSTYAVIISTLKKRRYIIESKNLKKIIPTKLGMAVKEYLMENYKQIVSEKRTVKLLEKMNEVEEGKVDYLVLLKELYNEIQTIS
What is the function of this protein?
Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process.  It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue.  May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity).  Its activity is inhibited by the DNA-binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase.
What are the official names of this protein?
Reverse gyrase 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
Protein: FGF2_HUMAN
Sequence: MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
What is the function of this protein?
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044).  Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677).  Binds to integrin ITGAV:ITGB3 (PubMed:28302677).  Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677).  Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3964259, PubMed:3732516).  Can induce angiogenesis (PubMed:23469107, PubMed:28302677).  Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879).
What are the official names of this protein?
Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor, bFGF, Heparin-binding growth factor 2, HBGF-2.
What is the protein family that this protein belongs to?
Belongs to the heparin-binding growth factors family.
What are the subcellular locations of this protein?
Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063).
Protein: ZAPC_XENBS
Sequence: MKIRPDDQWRWYFDSEHSRVMLDLANGMVFRSRFLAKMLTDYAITMEEMPFSVDDAALYYAFEEHFRCINIASELRAELALNGVVAFRFMKPQMPKSWYFSSFSVMTKPEQGEIVQVRLQDCGTEVLFMVAEVGDSASLCLLAQQKLELSDRVMNFCDPIKIMNDRLMPYVEPTRETIYGRVI
What is the function of this protein?
Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ.  Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
What are the official names of this protein?
Cell division protein ZapC.
What is the protein family that this protein belongs to?
Belongs to the ZapC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_BACFR
Sequence: MKVLVLNCGSSSIKYKLFDMDSKEVIAQGGIEKIGLKDSFLKLTLPNGEKKILEKDIPEHTVGVEFILNTLVSPEYGAIQSLEEINAVGHRMVHGGERFSKSVLLTKEVLEAFAACNDLAPLHNPANLKGVDAITAILPNVPQIGVFDTAFHQTMPEHAYLYAIPYELYKKYGVRRYGFHGTSHRYVSQRVCEYLGIKPEGLKLITCHIGNGGSIAAIKDGKCIDTSMGLTPLEGLMMGTRSGDIDAGAVTFIMDKEGLTTTGISNLLNKKSGVAGMMNGSSDMRDLEAAVAKGDPQAILTEQMYFYRIKKYIGAYAAALGGVDVILFTGGVGENQATCRAGVCEGLEFLGVKLDPEKNKVRGEEAIISTDDSRVKVVVIPTDEELLIASDTMAILDK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S26A4_RAT
Sequence: MAARDRRSEPPQLAEYSCSYAVSRPVYSELAFQQQRERRLPERRTLRDSLARSCSCSRKRAFGALKALLPILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQYGLYSAFFPILTYFVFGTSRHISVGPFPVVSLMVGSVVLSMAPDDHFLVPSGNGSTLNTTTLDTGTRDAARVLLASTLTLLVGIIQLVFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLIEIFQNIGDTNIADFIAGLLTIIVCMAVKELNDRFKHKIPVPIPIEVIVTIIATAISYGANLEANYNAGIVKSIPSGFLPPVLPSVGLFSDMLAASFSIAVVAYAIAVSVGKVYATKHDYIIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGGKTQVAGLISAVIVMVAIVALGKLLEPLQKSVLAAVVIANLKGMFMQVCDVPRLWKQNKTDAVIWVFTCIMSIILGLDLGLLAGLLFGLLTVVLRVQFPSWNGLGSVPSTDIYKSITHYKNLEEPEGVKILRFSSPIFYGNVDGFKKCVKSTVGFDAIRVYNKRLKALRRIQKLIKKGQLRATKNGIISDVGSSNNAFEPDEDVEEPEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAVSFLDVVGVRSLRMIVKEFQRIDVNVYFALLQDDVLEKMEQCGFFDDNIRKDRFFLTVHDAILYLQNQAKSREGQDSLLETITLIQDCKDPLELMEAEINEEELDVQDEAMRRLAS
What is the function of this protein?
Sodium-independent transporter of chloride and iodide (PubMed:12107249, PubMed:26791486).  Mediates electroneutral chloride-bicarbonate and chloride-formate exchange with 1:1 stoichiometry (PubMed:11208611).  Mediates electroneutral iodide-chloride and iodide-bicarbonate exchange (By similarity).
What are the official names of this protein?
Pendrin, Sodium-independent chloride/iodide transporter, Solute carrier family 26 member 4.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.