PharMolix/UniProtQA huggingface dataset:
Protein: MTNA_DROER
Sequence: MSLQSIKYSRGSLEILDQLLLPGQSKYEVVRGVEDGWKVINKMQVRGAPAIAIVGCLSLAVEINPEDFETKKSLRQEVEGKLNYLVSARPTAVNMKIAADELITLANDLYKDEAIDVNGMKQRFLDATEAMLKKDIADNRAIGANGAKAILQRVAEKGGAPAGSTGSVRVLTHCNTGSLATAGYGTALGVVRQLAELGKLEHVYCTETRPYNQGARLTAYELVHEKFPATLVLDSMVAALLRAKNVAAVVVGADRVASNGDTANKIGTYQIAVVAKHHDVPFYVAAPLTSIDLAIPGGDHIIIEERPDREMTHVGEHRIAAPGINCWNPAFDVTPASLITGIITERGVFKPAELKEAITKLLES
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PLC1_SCHPO
Sequence: MNCEMVTSPESVNLGDSNRAVSPFCLPDCSENAVAQTRSKTLDNAALDLPYVGNRKKSEQDFFKMLSSRDRDAHSTLRKRSNSLSSFLSTKSTSASENKFHGGLNWLSLKLNLLLRLQGRMNSARTNTSMNPYSCDSNENLSTLSSVNQNFNSRQLLATIVPESIQNGCSLLRITKKKVRQRKVSLDPISGYLMLDKNTGKAYKKLCVDDIKEIRQGRDARNYREQYKISSENEKRWFTIIYCADNKLKAMHMISPTLDAHNQWIMALEGLKTYRLNEFIIGLNLVCHQGEKMIDYSENLNPWEKLEKEQSAQLDLGDVHRMCQMLHLNASMEFLEETFQKADADHSGKLSFEEFQHFVSLLKTRSEIVDIFKEYTSGSDKMSLEQFRHFLSTSQKARLDSDSIRTLYVSFCSNDDSKMGLIEFTSFLLSPHNSPVVPVIQDMSRPLNEYLISSSHNTYLLGKQFGGESSIEGYIRSLQRGCKCIEIDCWDGPNGPVVCHGHTFTSMIKFNDVIDAIRKYAFVVSPYPLFISLEIHCCPDQQRQMVSYMKQAFGDTLVMKPVTANESVLPSPEDLLNKILLKVKCSATPLHQFSTDILKVGITDSSTDTTESSELENSELTGLRKGKRRMKNIIVQELQQLAPYARSLKFRNFSLPESKTYSHIFSFSERTIKKHGKAMVPRLSKHNLRYLCRVYPGPLRVGSTNFNPQVYWRLGVQMVALNWQTYDTGLQINDALFIADPPTGYLLKPPCQRIIGTTVGEEGLPRKIKLTIDVISGQQLRRARELSNSETLSPYVEIQVHSMEESPFRWCSKVVHENGFRPFWGETMVYESIISDDFYSMIRFLVHHRGSNGNDSIFANFTCPIDRLQQGYRHIRLLDMQGENLLFSSLFLKIKKEDI
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1, Phospholipase C-1, PLC-1.
Protein: FTSK_STRAW
Sequence: MASRQPAAKKPPAKKAAVPTKAPAKKAPAKKAAVRKAPARKVAAKKPAPKPAPNPTGGVYKLARALWLGVAHAVGAMFRGIGQGAKGLDPAHRKDGLALLLLGLALIVAAGTWSNLRGPVGDLVEMLVTGAFGRLDLLVPILLAVIAVRFIRHPEKPEANGRIVIGLSALVIGVLGQVHIACGAPARSDGMQAIRDAGGLIGWSAATPLTYTMGDVLAVPLLVLLTVFGLLVVTATPVNAIPQRLRLLGVRLGVVHDAQEGLAEDDERYDEQWREALPPNARRRGPAPAGYDPDGDEQEALSKRRSRPRRSAGQQPDLNRPMDAVDVAAAAAAALDGAVLHGMPPSPLVADLTQGVTVERDGYEETTPVPAARAKAVKPPRKEASKAGVPDLTKAPPAETRDLPARAEQLQLSGDITYSLPSLDLLERGGPGKTRSAANDAVVASLSNVFMEFKVDAAVTGFTRGPTVTRYEVELGPAVKVERITALTKNIAYAVASPDVRIISPIPGKSAVGIEIPNTDREMVNLGDVLRLADAAEDDHPMLVALGKDVEGGYVMANLAKMPHLLVAGATGSGKSSCINCLITSVMVRATPEDVRMVLVDPKRVELTAYEGIPHLITPIITNPKRAAEALQWVVREMDLRYDDLAAFGYRHIDDFNEAIRNGKVKLPEGSERELSPYPYLLVIVDELADLMMVAPRDVEDAIVRITQLARAAGIHLVLATQRPSVDVVTGLIKANVPSRLAFATSSLADSRVILDQPGAEKLIGKGDGLFLPMGANKPTRMQGAFVTEDEVEAVVQHCKDQMAPVFRDDVTVGTKQKKEIDEDIGDDLDLLCQAAELVVSTQFGSTSMLQRKLRVGFAKAGRLMDLMESRNIVGPSEGSKARDVLVKADELDGVLAVIRGEAAP
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: DNLI4_HUMAN
Sequence: MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDVVKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAIKALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDKCELQEENQYLI
What is the function of this protein?
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination (PubMed:8798671, PubMed:9242410, PubMed:9809069, PubMed:12517771, PubMed:17290226).  Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed (PubMed:9242410, PubMed:9809069, PubMed:12517771, PubMed:17290226).  Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction (PubMed:9242410, PubMed:9809069, PubMed:12517771, PubMed:17290226).  LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps (PubMed:17290226).  Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4 (PubMed:9242410, PubMed:9809069).  Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (PubMed:10854421).  LIG4 regulates nuclear localization of XRCC4 (PubMed:24984242).
What are the official names of this protein?
DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: YIBT_SALCH
Sequence: MAKIGENVPLLIDKAVDFMASSQAFREYLNKTPPRDYVPSEVPSESAPIYLQRLEYYRRLYRPKEEERG
What are the official names of this protein?
Uncharacterized protein YibT.
Protein: BCHN_HELMI
Sequence: MEGIERENGCFHTFCPIASVAWLHRKIKDSFFLIVGTHTCAHFIQTALDVMVYAHSRFGFAVLEESDLVAASPTAELAKVVEDIKAEWQPKVIFLLSTCSCDILKLDLENSSKDLTIRFGFPVVPVQTSGLDRTFTQGEDAVLHALLPFVPKEDPKVAVVEEKKRSWFSFGKDEGNKASVPAAPTRNLVLVGAVTDSTTQQLQWELKQLGLERVDVFPSGDITNMPVINEHTVIVPLQPYLSDTLATLRRERGAKVLTTLLPIGPDGTARFLEAICAEFGLDASPVAEREAQTWRSLESQRALLRGKRIMFLGDNLLEIPLARFLTACGAEVVEAGTPYVHAKDLSEEIARLREKGVPIVESPNFSAQVERIDRLRPDLIVAGLGICNPLEAAGYTTAWSIEFTFAQIHGFVNAIDLIKLFVKPLLKRQALLEQGWTEAGWMS
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit N, DPOR subunit N, LI-POR subunit N.
What is the protein family that this protein belongs to?
Belongs to the BchN/ChlN family.
Protein: MCL1_MOUSE
Sequence: MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
What is the function of this protein?
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation.  Mediates its effects by interactions with a number of other regulators of apoptosis.  Isoform 2 has antiapoptotic activity.
What are the official names of this protein?
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-related protein EAT/mcl1.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
Protein: W_SENDO
Sequence: MDQDALISKEDSEVEREASGGRESLSDVIGFLDAVLSSEPTDIGGDRSWLHNTINTLQRPGSTHRVKGEGEGEVSTSSTQDNRSGEESRVSGGTSEPEAEAHARNVDKQNIHWATGRGASTDSVPQDLGNGRDSGILEDPPNEGGYPRSGAEDENREMAANPDKRGEDQAEGLPEEIRRSAPLPDEREGRADNNGRGVEPGSPHSARVTGVLVIPSPELEEAVLQRNKRRPANSGSRSLTPVVVPSTRSPPPDHDNSTRSPPRKPPTTQDEHTNPRNTPAVRIKDRRPPTGTRSAPDRPTDGYPTHPSPETDATKKGA
What are the official names of this protein?
Protein W.
Protein: ALG6_CHICK
Sequence: MEKWSLMTITVLLALTVRWTVSLGSYSGAGKPPMYGDYEAQRHWQEVTYNLPIRQWYFNTSDNNLLYWGLDYPPLTAYHSFLCAYVAKLINPDWIALHTSRGYESQSHKLFMRTTVFVADLLIYIPAVILYCCSLKETSTKKKVSSALCILLYPGLILIDHGHFQYNSVSLGFALWGVLCLSYDWDLLGSAAFCLALNYKQMELYHSLPFFCYLLGKCFKKGLKGKGLLLLIKLAGTVVASFAVCWLPFCTDVEQIMQVLRRLFPIDRGLFEDKVANIWCSLSVLIKIKNVVSPQTQLKLSFAVTFLSLLPTCIKLTVQPSLRGFKLTLVSCALSFFLFSFQVHEKSILLVSVPVCLIINEVPFMATWFLLVSTFSMLPLLLKDGLLLPYAVTTLAFLSACVASFAIFEKTSAKDLQLKPFSQSLRGYVSWFKLFPKIVRSLFLLSVTLMGVLSVMSAAVHPPQRFPDLFPVSVSSISCLHFLFFLVYFNVIILWDSKNSRNQKKVS
What is the function of this protein?
Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity).
What are the official names of this protein?
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 6 homolog, Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG6/ALG8 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CASK_SHEEP
Sequence: MMKSFFLVVTILALTLPFLGAQEQNQEQRICCEKDERFFDDKIAKYIPIQYVLSRYPSYGLNYYQQRPVALINNQFLPYPYYAKPVAVRSPAQTLQWQVLPNAVPAKSCQDQPTAMARHPHPHLSFMAIPPKKDQDKTEIPAINTIASAEPTVHSTPTTEAVVNAVDNPEASSESIASAPETNTAQVTSTEV
What is the function of this protein?
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
What are the official names of this protein?
Kappa-casein.
What is the protein family that this protein belongs to?
Belongs to the kappa-casein family.
What are the subcellular locations of this protein?
Secreted.
Protein: CAF20_YEAST
Sequence: MIKYTIDELFQLKPSLTLEVNFDAVEFRAIIEKVKQLQHLKEEEFNSHHVGHFGRRRSSHHHGRPKIKHNKPKVTTDSDGWCTFEAKKKGSGEDDEEETETTPTSTVPVATIAQETLKVKPNNKNISSNRPADTRDIVADKPILGFNAFAALESEDEDDEA
What is the function of this protein?
Acts as an inhibitor of cap-dependent translation.  Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA.  Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631.  Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation.
What are the official names of this protein?
Cap-associated protein CAF20, 20 kDa cap-associated protein, CCR4-associated factor 2, p20.
What is the protein family that this protein belongs to?
Belongs to the CAF20 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED23_DICDI
Sequence: MYTNIPQQQQNIPQQQQQNIPQQQNVQNIQQPLPHTNIQQQNIQQQQQQYQLQFQKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQQQRPQTPQQNAQQQSQQSQQSQQQQASLGQGQQGSGPNTPPQSQPETIESIFKQLDLNSTGQQAKDILEQCKLKIHSLESQQLIAQAKYKLFSLAANYQSTVFQHIKMVSTTTTPTSTPTTSTTNTPQNSNTSSSSSTGTSSSTIGSSSSSTTTSTTNNENLGLPISKEIYQQKIQLWISIITFLRENLQYFGKWRESIYISIQNITQSTLLPTLIQKEFFTELFILLKSIFSFVNIEFPHYIALKEVKLSNTHQCLEYQNLIEPYYCRAAKLSSLLSLSSLSSSARIVGSSILLNQDAMIGYTNQLTESPPFFTSNRLLNNKYSTIVHHLLSQSASIEPIKELLFPQVQSNTLKSKIISIITEATISKTMQLLNKYPNQIIENQIENNSWKEWLLFSEQFYFLCENGLVDLEQFIVTLSEKRMNNGDPIKDNMVVLLISKTIIIQDVKTLFKQHLQNVNSNHYGHLIPLVLSFVNNDSNYPIISQNISLYFFLMRINTNTENPEIIAHIKKLLDNFNFQFTLFQQYRNWWESEKVKQKPEFFTTIQDITYFSIICNVIPTEGEMELIRFQSNGSDQSIQFPGVGGIGTVVTGKIKPVSNLILLNLSLRCRRKLIQESVLLLLDKEVPISPGFLEDYCRTVHYTPGPVSPFLFSYFKKFHRLAPIHAVIESVSHRLLKVLKSNKELAVLLRALQDIQTQKPIQNIQLSRSIDYLLLKASISLPVDLISAKEIWKSLDLGLFNNRRLITSIARLIKLKGIQDFNRISDVPVFIENCFKSNPYCFSKSTLEFFPDILKNEFKKNSENLSLNPNQFTNLTLMKPPTLQKVQLENQQRFQLFSVGGKLQILQKQALVQQYLTDNNSNLLLCQVFIYMLENKIKMDVMGPLIQQMFFKQIIGNQQPQQQQQPQQPPPLAISNQQLNRITSVFIDFIFDEVYVNHPLKQENLHQHVSEFLCQSIFTYKILTLNSVLLALLDRDDHPSMPTILDTFLFSSAEIQNRLQFFSTYPSDFFISQSFRNDDNYFIKNCEFNNRFNDLIPTVIDPNTLIEQSTQDTILPIYYSNSISRLMPIVEIIISKSIELNNGDLFEKTINHFNIPYHYYQDEKETTIKDTLIYYYDSQLFKLNPELKLLFLKLLNQSDIDNRFSNIFNQFLKSSRIEDITMVGSTAYFNDLISPLAEMMDLTNQNVFDTFSFKTENTFSSIDISNPLELKLNNIILEILLLPLDSNWIANGLVSLLNYSNRNKNFSDRKIDPPSSSMVLALSIIFSILPTQIHNSFIPIVTQNLSNELNFSKFKSPIMKNQYNFGNYTTNVEEKMTEPIEWYIYFIQFYYLYCPLERLLSLNDLVTNIRPLIKNVYQYYVLLTIVSPVLLRFGTQTNHLIQITREMLQILTDSYLSSYIENTLQDLESCWIGNTNDDDDIMDTTNFNLFGKRIGYDDDDDDEDDDYYDEDDEDEDDDNEDDQQDENDRMDFSQDTNNIFNRSMGDHDHLMMMSNSENLNDPWSDKNEFFRKQKSIFLKIDSQLIDTIIDWIYHIKMIFPFQPFRDELLRIVKEFKPNFLSKFNQLN
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Putative mediator of RNA polymerase II transcription subunit 23, Putative mediator complex subunit 23.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 23 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSMA2_STAAC
Sequence: MGIIAGIIKFIKGLIEKFTGK
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
What are the official names of this protein?
Phenol-soluble modulin alpha 2 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: NR0B1_PANTR
Sequence: MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVGREGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEATLGPCWGCSCGSDPGVGRTGLPGGRPVALLYRCCFCGENHPRQGSILYSLLTSSKQTHVAPAAPEARPGGAWWDRSYFAQKPGGKEALPGGRATALLYRCCFCGEDHPQQGSTLYCMPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELAQDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQPHLAPPAEARKVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYIQGLQWGTQQILSEHTRMTHQGPHDRFIELNSTLFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCTKI
What is the function of this protein?
Orphan nuclear receptor.  Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis.  Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions.  May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).
What are the official names of this protein?
Nuclear receptor subfamily 0 group B member 1, Nuclear receptor DAX-1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR0 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus (By similarity).
Protein: PER19_ARATH
Sequence: MHVISLSLSSIFFFLFLTSTILISPVQPTTSKPPAPRPHRELSADYYSKKCPQLETLVGSVTSQRFKEVPISAPATIRLFFHDCFVEGCDGSILIETKKGSKKLAEREAYENKELREEGFDSIIKAKALVESHCPSLVSCSDILAIAARDFIHLAGGPYYQVKKGRWDGKRSTAKNVPPNIPRSNSTVDQLIKLFASKGLTVEELVVLSGSHTIGFAHCKNFLGRLYDYKGTKRPDPSLDQRLLKELRMSCPFSGGSSGVVLPLDATTPFVFDNGYFTGLGTNMGLLGSDQALFLDPRTKPIALEMARDKQKFLKAFGDAMDKMGSIGVKRGKRHGEIRTDCRVFL
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 19, Atperox P19, ATP51.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DNAA_CLOPS
Sequence: MDAQLNNLWEQALNIIKGEISEISFNTWIKSCTPISISDNILKLSVPNEFTKGILDTRYKDLLIQALKIVTSRKFKIEFYLESDLEEEKENEEKQKEEKKDNTNDVDGSIVVSDEMSATLNPKYTFQSFVIGNSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHAIGHYILQENPKAKVVYVSSEKFTNELINAIKDDKNEEFRNKYRKVDVLLIDDIQFIAGKERTQEEFFHTFNALHEENKQIILSSDRPPKEIPTLEDRLRSRFEWGLIADIQPPDFETRMAILKKKADVEGLSVPNEVMVYIATKIKSNIRELEGALIRIIAYSSLTNRDVSVDLASEALKDIISNKESAPVTVKTIQESVANYYNLRIEDLKSQRRTRNIAYPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEKISENLKTDEGLQSMINDITKKLTQK
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUZ_ARMGA
Sequence: MSFIDSMKLDLVGHLFGIRNRGLAAACCALAVASTIAFPYIRRDYQTFLSGGPSYAPQNIRGYFIVCVLALFRQEQKGLAIYDRLPEKRRWLPDLPPRNGPRPITTSHIIQRQRNQAPDPKFALEELKATVIPRVQARHTDLTHLSLSKFEFHAEAIFLLPSVPIDDPKNVPSHDTVRRTKREIAHMHDYHDFTLHLALAAQDGKEVVSKGWGQRHPLAGPGVPGPPTEWTFIYAPRNEEELAVVEMIIEASIGYMTNDPAGVVIA
What is the function of this protein?
Luciferase; part of the gene cluster that mediates the fungal bioluminescence cycle (PubMed:30478037).  Uses the fungal luciferin 3-hydroxyhispidin as a substrate to produce an endoperoxide as a high-energy intermediate with decomposition that yields oxyluciferin (also known as caffeoylpyruvate) and light emission (By similarity).  The fungal bioluminescence cycle begins with the hispidin synthetase that catalyzes the formation of hispidin which is further hydroxylated by the hispidin-3-hydroxylase, yielding the fungal luciferin 3-hydroxyhispidin.  The luciferase then produces an endoperoxide as a high-energy intermediate with decomposition that yields oxyluciferin and light emission.  Oxyluciferin can be recycled to caffeic acid by caffeoylpyruvate hydrolase (PubMed:30478037) (Probable).
What are the official names of this protein?
Luciferase, Fungal bioluminescence cycle protein luz.
What is the protein family that this protein belongs to?
Belongs to the fungal luciferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PYRD1_HUMAN
Sequence: MEAARPPPTAGKFVVVGGGIAGVTCAEQLATHFPSEDILLVTASPVIKAVTNFKQISKILEEFDVEEQSSTMLGKRFPNIKVIESGVKQLKSEEHCIVTEDGNQHVYKKLCLCAGAKPKLICEGNPYVLGIRDTDSAQEFQKQLTKAKRIMIIGNGGIALELVYEIEGCEVIWAIKDKAIGNTFFDAGAAEFLTSKLIAEKSEAKIAHKRTRYTTEGRKKEARSKSKADNVGSALGPDWHEGLNLKGTKEFSHKIHLETMCEVKKIYLQDEFRILKKKSFTFPRDHKSVTADTEMWPVYVELTNEKIYGCDFIVSATGVTPNVEPFLHGNSFDLGEDGGLKVDDHMHTSLPDIYAAGDICTTSWQLSPVWQQMRLWTQARQMGWYAAKCMAAASSGDSIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGSDHELMLRCTKGREYIKVVMQNGRMMGAVLIGETDLEETFENLILNQMNLSSYGEDLLDPNIDIEDYFD
What is the function of this protein?
Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (PubMed:27745833).  Required for normal sarcomere structure and muscle fiber integrity (By similarity).
What are the official names of this protein?
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, myofibril, sarcomere.
Protein: HE_HEMPU
Sequence: MANFCLIFAAVFLTRLTTVLNTPISVTFGPTQLTDITKLVSETGDDFGLTTPRSAILTTVSEDDSDDDDGGESVEDTTILQTTTSSEIVISGIVVDEDIDESKVVKLKANLEQFGYVPLGSTFGEANINYTSAILEYQQNGGINQTGILDAETAALLDTPRCGVPDILPYVTGGIAWPRNVAVTYSFGTLSNDLSQTAIKNELRRAFQVWDDVSSLTFREVVDSSSVDIRIKFGSYEHGDGISFDGQGGVLAHAFLPRNGDAHFDDSERWTIGTNSGTNLFQVAAHEFGHSLGLYHSDVQSALMYPYYRGYNPNFNLDRDDIAGITSLYGRNTGSTTTTTRRPTITRTTTRRTTTRRTTTQLATTQTTTIRPPTYPTPPRQACTGSFDAVIKDNSDRIYALAGRYYWRLDQASPSWGVVRNRFGFDLPENVDASFQNGIFSYFFSGCYYYYQTSTRRRFPRTPFNRRWVGLPCDIDAVYKSGDSGTTYFFKGRFVYKFSSSNQLQRRSPISSYFRNTPYALRDGVEAVVRVDDVYLHFYRDGRYYRMIESTKQFVNFPNGLSYRDVIDTLIPQCRSLNLSVEIESCSNSSE
What is the function of this protein?
Allows the sea urchin to digest the protective envelope derived from the egg extracellular matrix; thus allowing the sea urchin to swim freely.
What are the official names of this protein?
50 kDa hatching enzyme, HE, HEZ, Envelysin, Sea-urchin-hatching proteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
Protein: PIMT_BURL3
Sequence: MSGERAKRFPLALEDLKRAPRKSEGRAGERHAAVAGSKAADKPAAVLKPVAVKPAAVRTALPGSAAAKPATAPKPTALKPAMPKPAAPSVAPAGAFALTSERVRERMVERLRANGVTDARVLEAMAAVPRHMFVDPGLATQAYEDSALPIGHQQTISKPSVVARMIELAMAGRTLERVLEIGTGCGYQAAVLSHVARDVYSIERIKPLYERAKLNLRPLRVPNIRLHYGDGRVGLPSAAPFDAIVIAAAGLDVPQALLEQLAIGGRLVAPVGAQSGQHQVLTLVERVAHAQWRESRLDRVFFVPLKSGVI
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.