PharMolix/UniProtQA huggingface dataset:
Protein: RS4_SHEAM
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDSKCKLETAPGQHGARKPRLSEYGTQLREKQKVRRIYGVLEKQFRNYYKEAARLKGNTGENLLQLLETRLDNVVYRMGFGSTRAEARQLVSHKSVMVNGRVVNIPSFKVSANDVVSIREKSRTQARIKAALEVAAQREKPTWVEVDAAKMEGAFKRLPERSDLSADINEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PUR5_LACP7
Sequence: MDYKKAGVDIEAGYKAVELMKKHIQGTMRSEVLTGIGGFSGAFSLTSFKDMEEPTLVSGTDGVGTKLKLAFILDKHDTIGIDCVAMCVNDIACAGGEPLFFLDYIACGKNEPEKIATIVSGVAEGCKQSNAALIGGETAEMPGFYPVEEYDLAGFAVGIVDRKKLITGDKLKHGDVLIGIASSGIHSNGYSLVRKVFRMEKEALNTYYESLSGTLGEVLLTPTKIYVKALNSLKTGNVEVKACSHITGGGFYENIPRMLREGVTAIVKKDSYVIPPIFHMLQKDGSIEEQMMYNTYNMGIGMMIAVDKADADKAVSLLSVAGETAYIVGEIQDGEKGICLC
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_ACTNA
Sequence: MIIESISGNIHDLPGEDLEDVHVESVVLPLADLTKRIQRVRSDHGTELGIRLAPGAPDLREGDILLRNERGIVVVRLEPTDVLVIAPVTVREMGVVAHNLGNRHLPAQFFGPAEPFPGLEGHDGVMVIQYDHTAEHYLEHLGVRHARMERSMPVPFRHAEHTH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN185_RAT
Sequence: MASKGPSASASTENSSAGGPSGSSNGTGESGGQDSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA
What is the function of this protein?
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1.  Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation.  Protects cells from ER stress-induced apoptosis.  Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway.  Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity.  Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF185, RING finger protein 185.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SUCC_NAUPA
Sequence: MNIHEYQAKEIFRKYGVPTPRGGVAFTGPEARRVAEELGGNLWVVKAQIHAGGRGKAGGVKLAKSLDEVEKIAEEMLGMTLVTHQTGPEGKVVKKVYIEEGADIKDELYLGMVLDRALEMPVMMASTEGGMEIEEVAEKTPEKIIKVAIDPAIGFQPFHARKLAFGLGLPKDEQREFIKFASALYNVYMDNDAEMIEINPLIKTGDGKFLALDAKMGFDDNALYKHPEIAEMRDLDEEEPTEVEAKKYGLSYIKLDGNVGCMVNGAGLAMATMDIIKHEGGEPANFLDVGGGANPDTVAKGFEIILSDPNVKSIFVNIFGGIVRCDRIANGILQATEKVEVNVPVIVRLDGTNAEEAAEILRNANIKNIIPAENLKDGAKKAVAAAKGEL
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: RIBBA_ACTPL
Sequence: MTDFQFSKVEDAIEAIRQGKIILVTDDEDRENEGDFICAAEFATPENINFMATYGKGLICTPISTEIAKKLNFHPMVAVNQDNHETAFTVSVDHIDTGTGISAFERSITAMKIVDDNAKATDFRRPGHMFPLIAKEGGVLVRNGHTEATVDLARLAGLKHAGLCCEIMADDGTMMTMPDLQKFAVEHNMPFITIQQLQEYRRKHDSLVKQISVVKMPTKYGEFMAHSFVEVISGKEHVALVKGDLTDGEQVLARIHSECLTGDAFGSQRCDCGQQFAAAMTQIEQEGRGVILYLRQEGRGIGLINKLRAYELQDKGMDTVEANVALGFKEDEREYYIGAQMFQQLGVKSIRLLTNNPAKIEGLKEQGLNIVAREPIIVEPNKNDIDYLKVKQIKMGHMFNF
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: CADH1_MOUSE
Sequence: MGARCRSFSALLLLLQVSSWLCQELEPESCSPGFSSEVYTFPVPERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLVRARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVNARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQQYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEITSYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVALIIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPNTSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTTLDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYGGGEDD
What is the function of this protein?
(Microbial infection) Does not function as a receptor for L. monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers receptor activity to this protein and promotes uptake of the bacteria.
What are the official names of this protein?
Cadherin-1, ARC-1, Epithelial cadherin, E-cadherin, Uvomorulin.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell- cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane (By similarity).
Protein: DCUP_ACIET
Sequence: MSFAPLQNDTFLRACRRQATDYTPLWLMRQAGRYLPEYKATRAKAGSFMGLATNVEYATEVTLQPLERFPLDAAILFSDILTVPDAMGLGLSFAEGEGPRFAKAVRDEADVAALAVPDLDKLRYVFDAVTSIRRALNGRVPLIGFSGSPWTLACYMVEGKGSDDYRLVKTLMYSRPDLMHRILAVNADAVAAYLNAQIDAGAQAVMVFDSWGGVLADGCFQDFSLEYTRRVLAQLKRTGVDGQDVPRIVFTKGGGIWLDDMKDIDCEVLGLDWTAHLGKARAIVGGQVGGPGKALQGNIDPNVLFAPSAQIVTQVRAVLDSFGTPHTDKTTTGPTHIFNLGHGISQFTPPEHVAALVEAVHGYSRSLRQR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANE_ACTPJ
Sequence: MSKLSHSEVLNTIRNGLIASCQPVDDGPMDKPEIVAAMAQASLIGGAAGLRIEGVDNLKATRPTVKAPIIAIVKRDLPDSPVRITPFLQDIDDLAAAGADIIAVDGTDRVRPVTIEAALKRIHELGCLAMADCSTLAEGLYCQQLGFDIVGSTMSGYTGGEVPNEPDYQLVKDLKAAGCFVMAEGRYNSPRLAKTAIEIGADCVTVGSALTRLEHIVGWFADEIKTAKV
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: DAPE_ACIF5
Sequence: MGKSAVLELAEDLISRPSVTPEDAGCQELMIARLKAVGFRVTRLPANGVENFWAERGGAGPRLCFAGHTDVVPSGPLAEWQNDPFQPIIRDGMLYGRGAADMKGSLAAMVVAAERFVALHPAHSGRLAFLITSDEEGIATHGTRHVVDWLREHGETIDWCVVGEPSSEKVLGDVIKNGRRGSLNGRLTVHGIQGHVAYPDKADNPIHRAFRPLADLVDQSWDAGNDFFPPTRLQFSNIHAGTGANNVIPGQLQADFNFRFSTESTPESLQAGVHKILDASAMRYTIDWQLSGPPFFTAPGPLVAATQKALQAVEQRVAQLSTGGGTSDGRFIAQLGGQVVELGPVNATIHKINECVAVADLEHLAQIYMEIMVHLLETANGR
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: XTH9_ARATH
Sequence: MVGMDLFKCVMMIMVLVVSCGEAVSGAKFDELYRSSWAMDHCVNEGEVTKLKLDNYSGAGFESRSKYLFGKVSIQIKLVEGDSAGTVTAFYMSSDGPNHNEFDFEFLGNTTGEPYIVQTNIYVNGVGNREQRLNLWFDPTTEFHTYSILWSKRSVVFMVDETPIRVQKNLEEKGIPFAKDQAMGVYSSIWNADDWATQGGLVKTDWSHAPFVASYKEFQIDACEIPTTTDLSKCNGDQKFWWDEPTVSELSLHQNHQLIWVRANHMIYDYCFDATRFPVTPLECQHHRHL
What is the function of this protein?
Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET).  Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.  Involved in internodal cell elongation.
What are the official names of this protein?
Xyloglucan endotransglucosylase/hydrolase protein 9, At-XTH9, XTH-9.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family. XTH group 1 subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Secreted, extracellular space, apoplast.
Protein: RIOX2_MOUSE
Sequence: MPKKVQPTGDENEEASVPCKRVKEELPETLSVLNFDSPSSFFESLISPIKVETFFKEFWEQKPLLIQRDDPVLAKYYQSLFSLSDLKRLCKKGVYYGRDVNVCRSISGKKKVLNKDGRAHFLQLRKDFDQKRATIQFHQPQRYKDELWRIQEKLECYFGSLVGSNVYMTPAGSQGLPPHYDDVEVFILQLEGTKHWRLYSPTVPLAHEYSVESEDRIGTPTHDFLLKPGDLLYFPRGTIHQAETPSGLAYSIHLTISTYQNNSWGDCLLDSISGFVFDIAKEDVALRSGMPRRMLLNVETPADVTRKLSGFLRTLADQLEGREELLSSDMKKDFVKHRLPPFFEGNGTETMDPGKQLPRLDNIIRLQFKDHIVLTVGPDKNPFDEAQQKVVYIYHSLKNVRQMHMIGEEEESEIFGLRFPLSHVDALKQIWCGSPIRVKDLKLDTDEEKENLALSLWSESLIQVL
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.  Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression.  Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity).  May play an important role in cell growth and survival.  May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
What are the official names of this protein?
Ribosomal oxygenase 2, Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA, Histone lysine demethylase MINA, MYC-induced nuclear antigen.
What is the protein family that this protein belongs to?
Belongs to the ROX family. MINA53 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: NRIF1_RAT
Sequence: MASTLPTTWPHESVKFEDVSLTFTKEEWAQLDLQQKCLYREIMMENYNNMISVEHHFSKPNVISQLEEAEDCWPMEREIRQDILPECSGPSLDPGMNSFPAESPLMKIKVVEVLTLNKDVAGPRNALIQSLYPESRENLNPGNLKPAKPSKRLTDTEALRQKFRHFQYEESAGPQKAVSRLRKLCHQWLQPNIRSKKQIIELLVFEQFLSALPEKFRVWLESQHPEDCRAAVALLENMTSVTKDDAQLVCSSEATDQLKEKRKDVATLPVTVPPEEPVTFQDVAVGFSQEEWRLLGPVQRTEYHDVMLETLGNLVSVGWEPTLENRAISPDSPIPVVKPIHDPNPKDLSRNGIQSTVFEIISQDRVQEIHTIESNQAGLLQEKSHPQKKLSESSKSQEGTNLHKSQGSLDEVPPRKHVKVKQKGTRKGKDRKNTISMTRGLRIRNQQKDSVEWQGRGDSNPMTHGYSIKNQRGSEQGTAGARRDPITLTVSAQFYQKATGSEEGRFRDNSNAIVPDTPTKIHQKSPEWHKVGRSNNSMSSVQNDQMGSGAGRGRDNTILTHALPVKIHQKGYEEGKVQGNRNSLRHVKAHQKGSKGERVRELSTSEKHVPYIKNHLKTSEREKGRENNDSIKYGPYIKTCYRGSEVRKLRRANNCTKAISRHAQQIFFIKIHKGSQVCRCSECGKMFRNSRYFSVHKKIHTGERPYMCMACGKAFVQSSSLTQHLRIHSGERPFECSECGRTFNDRSAISQHLRTHTGAKPYHCQHCGKAFRQSSHLTRHERTHTGERPYVCSNCGKAFTQSSHLIGHQKTHRIKFKKQPKL
What is the function of this protein?
Transcription regulator which may participate in NGFR/p75(NTR)-mediated apoptosis.  Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (By similarity).
What are the official names of this protein?
Neurotrophin receptor-interacting factor 1, Zinc finger protein 110.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: FEN12_ORYSI
Sequence: MGIKGLTKLLAEHAPGAAVRRRVEDYRGRVVAIDTSLSIYQFLIVVGRKGTEVLTNEAGEVTSHLQGMLNRTVRILEAGIKPVFVFDGEPPDMKKKELAKRSLKRDGSSEDLNRAIEVGDEDLIEKFSKRTVKVTKKHNEDCKRLLSLMGVPVVQAPGEAEAQCAALCENHKVFAIASEDMDSLTFGARRFLRHLTDLSFKRSPVTEFEVSKVLEELGLTMDQFIDLCILSGCDYCENIRGIGGQRALKLIRQHGYIEEVVQNLSQTRYSVPEDWPYQEVRALFKEPNVCTDIPDFLWTPPDEEGLINFLAAENNFSPDRVVKSVEKIKAANDKFSLGRGKLLAPVANLTGSTSTAGKEPKCILGGPGQVMKARSPLQVCKSSSLNFIHDNSKAFMLGRRSGFLRISTYASI
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1-B, FEN-1-B, Flap structure-specific endonuclease 1-B.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: RR16_ARATH
Sequence: MVKLRLKRCGRKQRAVYRILAIDVRYRREGRDLSKVGFYDPITNQTFLNLSAILDFLKKGAQPTRTAHDISKKAGIFTE
What are the official names of this protein?
30S ribosomal protein S16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PPCS_HUMAN
Sequence: MAEMDPVAEFPQPPGAARWAEVMARFAARLGAQGRRVVLVTSGGTKVPLEARPVRFLDNFSSGRRGATSAEAFLAAGYGVLFLYRARSAFPYAHRFPPQTWLSALRPSGPALSGLLSLEAEENALPGFAEALRSYQEAAAAGTFLAVEFTTLADYLHLLQAAAQALNPLGPSAMFYLAAAVSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLETDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEEKIVDNLQSRHTAFIGDRN
What is the function of this protein?
Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine (PubMed:11923312, PubMed:12906824, PubMed:29754768).  Has a preference for ATP over CTP as a cosubstrate (PubMed:11923312).
What are the official names of this protein?
Phosphopantothenate--cysteine ligase, Phosphopantothenoylcysteine synthetase, PPC synthetase.
What is the protein family that this protein belongs to?
Belongs to the PPC synthetase family.
Protein: RN167_RAT
Sequence: MHPAAFPLPVVVATVLWGAAPIRGLIRATSEHNASMDFADLPALFGATLSDEGLQGFLVEAHPENACSPIAPPPSAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSAEYLRALFVYEKGARVLLVPDNSFPLGYYLIPFTGIVGLLVLAMGTVLIVRCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDEYDVCAICLDEYEDGDKLRILPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEEQEEETQGQEEEGDEGEPRDQPASEWTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPSPSPSSAALA
What is the function of this protein?
E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway.  Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1.  Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex.  Also involved in protein trafficking and localization.  Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2.  Does not catalyze ubiquitination of GluA1/GRIA1.  Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3.  Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B.  Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18.  Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF167, RING finger protein 167.
What is the protein family that this protein belongs to?
Belongs to the Godzilla family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane. A subpopulation localizes to the cell membrane of neurons.
Protein: PDXH_NOSP7
Sequence: MDKTVADLRKDYTLEGLSELEVDLNPFIQFKKWFDQALAGQLPEPNAMTLATVTPDGKPSARMVLLKDFDERGFAFFTNYNSRKGQELAENPLAALVFWWAELERQVRICGYVEKVSETESDQYFDTRPPNSRLGAWVSNQSEVIESREVLERRMQEFYSKYENQEIPRPPHWGGLRVIPTEIEFWQGRSSRLHDRLLYSRLDNGTWKIDRLSP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RLMD_SHEPW
Sequence: MAQFFKAKPNRSKQLSSKLSLNVTQLDHLGAGIAHHQGKIVFINGALPGETVQVQLTEQKKKFSRAKLLKVETASGERVSPLCIHYEKCGGCDLQHLNVESQRAHKAKALQELVAKFAQTTASQVCETLSDSPWHYRRRARLATWFDKKTKHISLGFRASSSSDVVEIQSCVVLAKPLSALIPELAFLLNQLSGKKALGHVELTLADNGIFVVLRVTKALSDKDRQRLAEFGASHSLNMLLQDDDANTESLSGHGQQPFYSFNDSDAELKFSAGNFIQVNASVNQAMVNQAVDWLAPQANERVLDLFCGIGNFSLPLAKSGAEVIGVEGVPAMVEQATVNAKGAALDKVSFYHADLSADLSQQPWLGKVDKMLIDPARAGAYESMLSLKKLKPQALVYVSCNPASLARDSEVILKQGYRLTKIAMVDMFPQTHHLESMALFELGK
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: PROT_UNKP
Sequence: MPQPAIIAKLEQQLRITIAPFDAPDLKAFMRYGRKGDDNSQYFLKDGKLTGLKLRTLGLKDTSFLEERELAGLQGLYLAENDFSSLQLPGHLQQLRLLHLADNKELKTLEFAGSMPLLEEIDLSDSGIQTLQLPACPALQKLDVSRSKLEAFSFASACPALWWLDLSGNGELRKLKMPAGFKALQYLYLYKSGIQELQINGKLPKLVVLDLEGNQLKQWPEKLLLPEGLETLYLEGNPIENIPETIRGSGERHNSVEDVRQYLLSIIDEDKVEYLHQAKMILVGNGEVGKTSIRLKLLDSKATLPKKKDRTQGLDIVPYELKALSPDLTGLEDAIDFQLNIWDFGGQGKYREVQQLFFSPQSLYLFVTACDDTPEDKESYVTFDYWMSLVHALSYDREQERSSPVIHVVNKIDKERMDIDQTAHNRFGNVEEFHAISCKHLTNFEALRKAIPRVLPKVGQGIFRDQYNEDWLGVMEELQRRQGEHHITYQEYRDEVCKDRLNDGEARAWLRILDRIGTVIYFGENEKLKDWIILNPNWVKQAVFEVIDSGERNPVPQWRFEKQIWSHYSEKEREKLFELLQAYDLAYKQQNAFGEQEFVVPALLEHESPNYQDLLPQEELPLKLRFAFKPILPAGTVNKLMVRLKDYIYRGLMWKDNVVFHHPDSNAYVQVEEDWQEHFIYLSVYGKQPSVIYETVTSTLKDINNDFKNAKFLKELEFTVEGFDGEEWMKKRLLKKAGADFFNFLWEKPGIHYKEEDEKNIMDQVKELIAKNRVGDALEMLKSLVPAHLEAEVLQLISRYSKLQRDSRMGILANNDENVERNRIVSSILNLASEAERDNDHTGLSDSSDQEDETFTNVTDQTKKILFICSSPSGKNLLDFGKEFKSIGIARQLADSRDDYAEPIIKTSVEADDLLHIMTKYQPDILHISLHSSKSKGLYFENNAGQAEPISAEDFKDIIETYASDPDGKGRIETIVLSCCDSEAYGRAITNFADHIVVTKDLFPDKAAVVYAKDFYRMLFNNKDIGFAHRSATSAIKRKKYPSDGFAHPIHEIPFLIKNDDK
What is the function of this protein?
A dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death.  Probably involved in defense against bacteriophages.  Expression of bGSDM and this neighboring protease is highly toxic in E. coli.
What are the official names of this protein?
Roc-COR-CHAT protease, Protease Ga0307981_100051430.
Protein: ARGB_METM6
Sequence: MEQYTKAEILIEALPYICKFHDQKFLIKYGGHAMVNEQARNWIAKDLVLLKYVGINPIVVHGGGPEINRAMEKMGKTPEFIHGLRVTDEETLEIVKMVLIGKINGDIVSKLERYGGKAVGLSGKSGQLIKAKKKIQYLMKDSQKIEIDLGMVGEVEHVDTKLIDILVEKRYIPVISPIGVDHQGNDLNLNADIAAGDIAGAMNAEKLIMVTDVDGIMDDINDQSTLHRRLTISQIEDMIEKGFITGGMIPKIEACINALDKGVQSVHIVNGKTPHAVLLEIFTEEGVGTMIVKE
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y362_MYCPN
Sequence: MNLYELFLNQKLLYGTDPHFNGVFLTLLEKFGLHFKDLTALWKHAKTITDFDEQGIVNALKAYFVDQLPLPYITGSVKLGSLTFKTQPGVFIPRADSLALLKVVKAQNLKTAVDLCCGSGTLAIALKKRFPHLNVYGSDLNPQALQLAAQNARLNMVEVQWIEADFLAALAQVNTPIDLIITNPPYLNESQLDQTLNHEPRNSLVADGNGILFYQKLYNFLLGNRQVKQVILECSPTQKKEFLALFSIFKTSEIYTSHKQFIGLSIDNTKLPVLKIAQTKQIKALLDKGMTAIIPTDTQIGLMSYCQQDLDHIKQRDPNKHYVQFLAPSQINQLPKQLQKLAKLFWPGAYTFIVDGQSYRLPNSPQLLKLLKTVGLIYCTSANQAKQKPFGKLSAYQNDPYWVQQNCFIVQNSFKSNNEPSLIYNLDTKQIVRGSSTQLQRFQALLAKHKLRH
What are the official names of this protein?
Uncharacterized protein MG259 homolog.