PharMolix/UniProtQA huggingface dataset:
Protein: MTH9_DROME
Sequence: MVSPLIILLIIWLSVGAKSVEIASINHPCAYAHTVNITDGLRMKDGSYSYAGVVVPPHLMAEYSFKVIDGVEYRAKKHLRGCVCLLKPCISFCCPENLVFDAKHWNCTMPHQVRESTHVELTYANRTVDQVRIRDRFVVRTELGCRNKFVDKKHDNFWQWDLFENGTLRRDNRLWSTDEYCFSPLEHNPEQWELTPLNCERFQTGYRVWIYAICSIIAIIINIFILSLLGSVRDARKSHYGQLIIYYLLSMIVGYSLLVYLALKNPMKLSHVACRNIGFLAYFCIMLSFVFLAICSLDFLLKFKQKAVRSSVRRLSLALAVLAVIGLRFLVSLAQDSKLPKHFKPGMGEDYCWFDVRTWGILIYYYGPIALLLIFSIVCCLKAYFSIYELPPDTQYILGTQLKIVKTHFYAFSAYIVGVFAVWIREIVVYIMARVREHFFIIDFWSGICILGLAIAGFILLLGKNLHVKSWWAINVESSQTDLSIINARVYKFDEKGDLKSSDSPYKPTVTSL
What are the official names of this protein?
Probable G-protein coupled receptor Mth-like 9, Protein methuselah-like 9.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Mth subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECF_STACT
Sequence: MKLNALQLENYRNYEEVVLDCHPDVNILIGENAQGKTNLLESIYTLALAKSHRTSNDKELIRFNAEYAKIEGELSYRHGKMPLTMFITKKGKKVKVNHLEQHRLTQYVGHLNVVLFAPEDLNIVKGSPQVRRRFIDMELGQISAVYLNDLSQYQRILKQKNNYLKQLQMKQKTDRTMLEVLNQQFAEYALKITLKRVHFINELETLAKPIHSSITDERETLDLEYRPSLKLSEETDEAKLYEEVQKLLQDNMEREIERGVALYGPHRDDLGFKVNEMDAQTYGSQGQQRTTALSIKLAEIELINIEVGEYPILLLDDVLSELDDSRQTHLLSTIQDKVQTFVTTTSVEGIDHEIMKHAKLYRINQGEIIK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O1094_MOUSE
Sequence: MSIHSPGYTVRRIPVNNVTDTTMFILTGFTDDADLQVLLFLLFFVIYLFTLIGNLGLVLLVIGDSRLHNPMYYFLSVLSFLDACYSTVVTPKMLVNFISNDKSISYPGCVTEMFLFVTFGTTECFLLAAMAYDRFVAIYNPLLYAVKMSPRVYIPLIIACYSGGIMHATIHTVATFSLSFCASNEIRHVFCDIPPLLAISCSNTNINQLLLFYCVGSIEIITILIVLVSYSFILFAILKMNSAEGRRKIFSTCGSHLTGVSIYHGTILFMYVRPSSNYALEHDMIVSTFYTIVIPMLNPIIYSLRNKDVKEAMKKIFERNFFMNKVHFKL
What is the function of this protein?
Potential odorant receptor.
What are the official names of this protein?
Olfactory receptor 1094, Olfactory receptor 179-7.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PGK_MYCSJ
Sequence: MAVKTLEDLLNDGDREIAGRGVLVRSDLNVPLDDNGAITDPGRIIASVPTLEALAEAGAKVIVTAHLGRPKGGPDPKYSLKPVAAALSEKLGRHVQLAGDVVGTDALARAEGLTDGDVLLLENIRFDPRETSKDDGERRKLAEALVELVGDDGAFVSDGFGVVHRKQASVYDIATLLPHYAGTLVAAEVKVLEQLTSSTDRPYAVVLGGSKVSDKLAVIESLAKKADSLVIGGGMCFTFLASQGVSVGKSLVQPEMIDTCRELLDTYGDVIHLPVDIVVAPEFSADAEPETVAADRIPEDKMGLDIGPESVKRFTNLLSNARTVFWNGPMGVFEFPAFAAGTKGVAEAIIGATAKGAFSVVGGGDSAAAVRQLGLAEDGFSHISTGGGASLEYLEGKELPGIQVLES
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TECT3_MOUSE
Sequence: MCTLQLHLLLLVVLMLSETARPQPSSTARAFPTSWGLEPVTPEVPTSAPPDSSESPTPWTLSMPVNATTDPFPALPICVCDLTPGTCDLNCCCDKDCDLLHPRTVFSFCLPGSVRSSSWVCVDNSLMFRSNSPFPSRVFTDSSGTTQFCVRVNNSKANYFQKLQTVNATNFQALAAEFGGQSFPSMPPETQPPVLFYRAGDPILTYYPSWSVVSLLRQPAAVGAGGLCAESNPAGFLESKSTTCPRFFRDLASSCTSEPALDAASYYNFRVLKVPRGVTDLQNMKFQVPVTLASQASPPLLAGNTCQNIVSQVVYEIETNGTFGIQKVSVSFRQTNLTVKPGVSLQQDFIVHFRAFQQRKAAAPAAPRSGNPGYLTGKPLLVLTGDTSHSMTLLQSEGNGLCSAKRHAVQFGVNAVSGCQLRPREVNCSHLQEEVYQTLHGRPRPEHVAVFGNADPAQRGGWTRILSRDCSVSAVNCTSCCLIPVSLEIQVLWAHLGLQSNPQAHVAGARFLYQCKSVQEHQRGIEVSLTTLVNFVDITQKPEPPRDQPRIDWKLPFDFFFPFKAALSRGASVQKDSLVLILCVLLLGLLNSQTK
What is the function of this protein?
Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.  May be involved in apoptosis regulation (By similarity).  Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
What are the official names of this protein?
Tectonic-3.
What is the protein family that this protein belongs to?
Belongs to the tectonic family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: TSAD_MALP2
Sequence: MYILSIETSCDDTSVAILEDNKVLSCIIKNDSKQLNPFGGIVPEIVARYHEENIIKALDLALQESNISLNQIDKVAYTNQPGLPGSLFVGEIFAKTMAYALDVECVPINHIHGHILSPFINSVPKYPFMSLIASGKTTSIFLVKSANEIIELTKTRDDAIGEIFDKVGKALGYDYPAGPKLDKYFDISKATITPSFPPVKNDFSFSGIKNKFLSIINSSKMKNEEIDTITIGSSFLKYSIDLIIKKLKYYKDEYSVDCVCIGGGVANNNYFKQEIKKLFSDSFVPESKYSTDNAAMIGFAYYEKNK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADC_ECOLI
Sequence: MPPRRYNPDTRRDELLERINLDIPGAVAQALREDLGGTVDANNDITAKLLPENSRSHATVITRENGVFCGKRWVEEVFIQLAGDDVTIIWHVDDGDVINANQSLFELEGPSRVLLTGERTALNFVQTLSGVASKVRHYVELLEGTNTQLLDTRKTLPGLRSALKYAVLCGGGANHRLGLSDAFLIKENHIIASGSVRQAVEKASWLHPDAPVEVEVENLEELDEALKAGADIIMLDNFETEQMREAVKRTNGKALLEVSGNVTDKTLREFAETGVDFISVGALTKHVQALDLSMRFR
What is the function of this protein?
Involved in the catabolism of quinolinic acid (QA).
What are the official names of this protein?
Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NadC/ModD family.
Protein: Y1878_STRGG
Sequence: MNARGALGRYGEDLAARLLAEAGMAVIERNWRCRAGEIDIVARDGDALVFCEVKTRRSPGFEHPMAAVGPVKADRLRRLAEIWLDRHGGPPPGGVRIDLVGVLVPRRGAPVTEHARGVS
What are the official names of this protein?
UPF0102 protein SGR_1878.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: PTGR1_RABIT
Sequence: MVRAKNWTLKKHFHGHPTDSDFELKTVELPPLNNGEVLLEALFLSVDPYMRLGSKRLKEGDTMMGQQVARVVESKNPAWPVGTLVLAHSGWASHSISDGQQLEKLLTEWPDTLPLSLALGTVGMPGITAYFGLLEICGAKSGDTVLVNAAAGAVGAVVGQIAKIKGCRVVGAAGSEEKVDYLKKIGFDFAFNYKTVKSLEETLKKAAPDGYDCYFDNVGGEFSNTVIRQMKKFGRVAICGAISMYNSTGQLPPGPSPESVLYQEIRMEGFIFNRWKGEVGQKALKELLTWVLEGKIQYREFVIEGFENMPAAFMRMLKGENVGKARSESLKSGTCKPGDHPHDLIFPIT
What is the function of this protein?
NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX).  Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity).  Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity).  Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity).  Plays a role in metabolic detoxification of alkenals and ketones.  Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (By similarity).  May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity).
What are the official names of this protein?
Prostaglandin reductase 1, PRG-1, 15-oxoprostaglandin 13-reductase, ADRAB-F, Dithiolethione-inducible gene 1 protein, D3T-inducible gene 1 protein, DIG-1, Leukotriene B4 12-hydroxydehydrogenase, NAD(P)H-dependent alkenal/one oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the NADP-dependent oxidoreductase L4BD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPKA_PYRAB
Sequence: MPERVVIALGGNALQQRGQKGTYEEMMENVKKTAKQIAEIIARGYEVVITHGNGPQVGTILLHMDAGQSLHGIPAQPMDVAGAMSQGWIGYMIQQALRNELRKRGIEREVVTIVTQTIVDKDDPAFENPTKPVGPFYDEETAKKLAKEKGWVVKEDAGRGWRRVVPSPDPKRHVEAETIKKLVEDGVIVIASGGGGVPVIEEDGEIKGVEAVIDKDLAGERLAEEVNADILMILTDVNGAALYYGTEKETWLREVKVDEMERYYQEGHFKAGSMGPKVLAAIRFVKNGGKRAIIAHLEKAVEALEGKTGTQVIP
What are the official names of this protein?
Carbamate kinase, Carbamate kinase-like carbamoylphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VGK_BPPHK
Sequence: MKHVNTLLMQELRLLICELKRLKLSAVSDPDFSQEKIHAELDSLLCKLSRHFD
What is the function of this protein?
No function has yet been ascribed to K protein.
What are the official names of this protein?
K protein.
Protein: RNFD_YERPS
Sequence: MQIASSPFTHNQRSTRRIMLLVILACIPGIIAQTYFFGYGSLIQVMLAMITALLAEGAVLQLRKQPVMARLQDNSALLTALLLGISLPPLAPWWMIVLGTLFAIVIAKQLYGGLGQNPFNPAMVGYVVLLISFPVQMTSWLPPLPLQGTSVGFYDSLLTIFTGYTHSGENIHQLQVGYDGISQATPLDTFKTSLRSQPADQILQQPIFGGVLAGLGWQWVNIGFLVGGLLLLWRKAIHWHIPVSFLLALGGCAAVSWMIAPQSFASPMLHLFSGATMLGAFFIATDPVSASTTPRGRLIFGALIGILVWLIRVYGGYPDGVAFAVLLANITVPLIDHYTQPRVYGHKSGHK
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBIC_YERPS
Sequence: MFIGDASILKPIQWCATEHPELPADIADWLMELGSMTRRFEQHCQRVHVEPQRECFITRDALGEEAEHLPVSQRYWLREIVLFGDNVPWLLGRTVIPEETLSGPDRALVDLGTLPLGRYLFSGDALTRDYIHVGRQDNLWARRSLLRLSGNPLLLTEVFLPASPLYTHCDSIPK
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPZP_STRAQ
Sequence: MSESAELTELYSAIEETTRVVGAPCRRDTVRPILTAYEDVIAQSVISFRVQTGTSDAGDLDCRFTLLPKDMDPYATALSNGLTAKTDHPVGSLLEEVHRQFPVDCYGIDFGAVGGFKKAWSFFRPDSLQSASDLAALPSMPSGVSENLGLFDRYGMTDTVSVVGFDYAKRSVNLYFTGASPESFEPRGIQAILRECGLPEPSDELLRFGEEAFAIYVTLSWDSQKIERVTYSVNTPDPMALPVRIDTRIEQLVKDAPLGSAGHRYVYGVTATPKGEYHKIQKYFQWQSRVEKMLTADAG
What is the function of this protein?
Involved in the biosynthesis of prenylated phenazines.  Catalyzes the transfer of a dimethylallyl moiety to C-9 of 5,10-dihydrophenazine 1-carboxylate (dihydro-PCA).  Specific for both dimethylallyl diphosphate and dihydro-PCA.
What are the official names of this protein?
5,10-dihydrophenazine-1-carboxylate 9-dimethylallyltransferase, Dihydro-PCA dimethylallyltransferase, Dihydro-PCA prenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the aromatic prenyltransferase family.
Protein: RL11_DECAR
Sequence: MAKKIIGYIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAQTQGVEPGLPIPVVITAFADKSFTFVMKTPPATILIKKAAGIKSGSAKPHTDKVGKITRAQCEEIAKTKSPDLTAADMEAAIRTIAGSARSMGITVEGL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: YKZI_BACSU
Sequence: MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIEQSKNKLERLRKEWIRLNG
What are the official names of this protein?
Uncharacterized protein YkzI.
Protein: Y529_ARCFU
Sequence: MMMTDLPENIRKTAVALLRLGEATAEDIAKITGRKRSTESYYLNLMADLKLVKKKKVGRKIYFIFNSRDQEKRQ
What are the official names of this protein?
Uncharacterized protein AF_0529.
Protein: PSBT_TROAR
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPKVPTKKMK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ACKA_YERPE
Sequence: MSSKLVLVLNCGSSSLKFAIIDATNGEEHISGLAECFHLPEARIKWKVDGGKQEAALGAGAAHSEALNFIVNTILAQKPALSAQLTAIGHRIVHGGEKFTSSVIVTEDVIQGIKDSIPFAPLHNPAHLIGIAEALKSFPNLADKNVAVFDTAFHQTMPEESYLYALPYSLYKDHGIRRYGAHGTSHFYVSQEAAKILNKPLEELNVITCHLGNGGSVTAVRNGKCVDTSMGLTPLEGLVMGTRSGDLDPAIIFHLHDAMGMSVDQINTLLTKESGLLGLTEVTSDCRYVEDNYATKADAKRAMDVFCHRLAKYIGSYTALMDGRLDAVVFTGGIGENAAMVRELTLDKLGLLGFEIDHERNMAARFGKSGTITKDSSRLALVIPTNEELVIAQDAARLTA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG095_VACCC
Sequence: MGAAASIQTTVNTLSERISSKLEQEANASAQTKCDIEIGNFYIRQNHGCNLTVKNMCSADADAQLDAVLSAATETYSGLTPEQKAYVPAMFTAALNIQTSVNTVVRDFENYVKQTCNSSAVVDNKLKIQNVIIDECYGAPGSPTNLEFINTGSSKGNCAIKALMQLTTKATTQIAPRQVAGTGVQFYMIVIGVIILAALFMYYAKRMLFTSTNDKIKLILANKENVHWTTYMDTFFRTSPMVIATTDMQN
What is the function of this protein?
Component of the entry fusion complex (EFC), which consists of 11 proteins.  During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation.
What are the official names of this protein?
Entry-fusion complex associated protein OPG095, EFC-associated protein OPG095, Protein L1, Virion membrane protein M25.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG095 family.
Protein: PYRB_CHLSY
Sequence: MTELRRHAIDLDNFSATEIEEILETAESMREVLSREIKQVPALRGKTVVNMFFEESTRTRISFELAARALSANVVAFTARGSSVEKGESLVDTVRTLQALGADIIVMRHSQSGAPYLVARHFRGSLINAGDGRHAHPTQALLDLYTMQSRLGQIRDLHVVIVGDILHSRVVRSNLWGLTRLGARVTLCGPPTLIGPAAFWTATWPQVRIAYELDPLLPEADVVMALRLQKERMQSGLLPALREYTRIYGLTSERLARLPSHAIVMHPGPMNEGIEIFPEVATASPAVIEEQVTNGVAVRMALLYRMAG
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL3_BACAA
Sequence: MTKGILGRKIGMTQVFAENGELIPVTVIAANPNVVLQKKTTETDGYNAIQLGFEDKREKLTNKPEQGHTAKASTTPKRFIREIRDADVDGLEVGQEVKVDVFATGEIVDVTGISKGKGFQGVIKRHGQSRGPMSHGSRYHRRPGSMGPVAPNRVFKGKKLAGRMGGDQVTIQNLEIVQVDTERNLLLVKGNVPGAKKSLVVVQGAVKVSK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: QCR9_HUMAN
Sequence: MAAATLTSKLYSLLFRRTSTFALTIIVGVMFFERAFDQGADAIYDHINEGKLWKHIKHKYENK
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
What are the official names of this protein?
Cytochrome b-c1 complex subunit 9, Complex III subunit 9, Complex III subunit X, Cytochrome c1 non-heme 7 kDa protein, Ubiquinol-cytochrome c reductase complex 7.2 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the UQCR10/QCR9 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: FABA_SALSV
Sequence: MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTARKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTAHDLKVGLFQDTSAF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLA1A_MOUSE
Sequence: MRPGLWETCFWLWGPLLWLSIGSSGNVPPTTQPKCTDFQSANLLRGTNLKVQFLLFTPSDPSCGQLVEEGSDIRSSEFNASLGTKVIIHGFRALGTKPSWIDKFISAVLRAADANVIAVDWVYGSTGVYYSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGQITGLDPAGPEYTRASLEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFFHAGYNYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVMIEPLPKEVKVYLLTTSSAPYCVHHSLVEFYLKEKRKKDTSIEVTFLSNNVTSSVKITIPKQQLEGRGVMAHPNPQCQINQVKLKFQVSSRVWRKDRTPVVGTFCTAPLPVNDSKKTVCIPEPVRLQAGVPAFQDLKIACV
What is the function of this protein?
Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (By similarity).  Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production.  Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity).
What are the official names of this protein?
Phospholipase A1 member A, Phosphatidylserine-specific phospholipase A1, PS-PLA1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: PCSK9_PLEMO
Sequence: MGTVSSRRLWWPLPLLLLLLLGPPGARAQEDDDGDYEELVLALRSEEDGPADALQHGATATFHRCAKDPWRLPGTYVVVLKDSDAHRSQPERTARRLQAQAARRGYLIKLLHVFHHLLPGFLVKMSRDLLELALRLPHVDYIEEDSSVFAQSIPWNLERITPARYRADEYQPPNGGSLVEVYLLDTSIQSSHREIEGRVMVTDFESVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGASLRSLHVLNCQGKGTVSSALIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACRRLAGAGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPLTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSRSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVATLPPSTHGAGWQLFCRTVWSAHSGPTRMATAMARCAPDEELLSCSSFSRSGKRRGERIEAQGGRRVCLAPNAFGGEGVYAVARCCLLPQANCSVHTAPPAGAGMGTRAHCHQQGHVLTGCSSHWEMKDLGTHKPPVLKPRGQPDQCMGHSGASTHASCCYAPGLECKVKEHGLPAPQEQVTVACEEGWTLTGCSALPGTSHVLGAYAVDDTCVVRSRDVSTTGSTSEEAVAAVAICCRSRHLA
What is the function of this protein?
Crucial player in the regulation of plasma cholesterol homeostasis.  Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments.  Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway.  May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation.  Can induce ubiquitination of LDLR leading to its subsequent degradation.  Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner.  Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.  Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation.  Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways (By similarity).
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 9, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation (By similarity).
Protein: QUEA_SALSV
Sequence: MRVTDFSFELPESLIAHYPQPERSRCRLLSLEGPTGALTHGTFTDLLDKLNPGDLLVFNNTRVIPARLFGRKASGGKIEVLVERMLDDKRILAHIRASKAPKPGTELLLGDDESIHATMTARHGALFEVEFNDPRPVLDILNAIGHMPLPPYIDRPDEDADRELYQTVYSEKPGAVAAPTAGLHFDEPLLAALREKGIEMAFVTLHVGAGTFQPVRVDTIEDHIMHSEYAEVPQEVVDAVLAAKARGNRVIAVGTTSVRSLESAAQAAKSDLIEPFFGDTQIFIYPGYQYKVIDALITNFHLPESTLIMLVSAFAGYQHTMNAYKTAVEQKYRFFSYGDAMFITYNPQAIFERP
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSU72_CRYNB
Sequence: MCHKVEEDRYFVWFVRAITKNSFRVVSAGTGSAVRLPGPAIDKPNVYRFGTPYDDIYRDLESQDPQLYTRNGILPMLDRNRKVKKAPEKWQELKSVLADVVITCEERCYDAVCDDLLTRSGEYNRPIHIINIEIKDNPEEAHIAGQSILELARAIEASDDLDSDIDAILNAHGDKHPHTLLHTVGFY
What is the function of this protein?
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.  SSU72 is required for 3'-end formation of snoRNAs (By similarity).
What are the official names of this protein?
RNA polymerase II subunit A C-terminal domain phosphatase SSU72, CTD phosphatase SSU72, Suppressor of SUA7 protein 2 homolog.
What is the protein family that this protein belongs to?
Belongs to the SSU72 phosphatase family.
What are the subcellular locations of this protein?
Nucleus.