PharMolix/UniProtQA huggingface dataset:
Protein: MDR3_ENTH1
Sequence: MISNPSETKVSNFDDFSVFDVTPDPDELARKHKKPNDHGSVSIKELYRYAGFIDYILLIGGIIGAMAAGVLQPMQMLVMGDMMDTFDTSSMQNMDFSNISKAEQIEMNYELTASVADTINDLVLKMIYFAIGTTVGMFLMHFCFFVLSERQGIKIRMLYFRALLRQDAGWYDFHESGELTSRIASDVQQIQDGMSQKFGVLFQTICGFIAGYAIGFSKCWDLTLVIMAVTPFMLITVLFLGFFATKFTAKGENSLSDAGAIAEATIGNMRTVQSLGQEHEFADAYDKKMDSIKKYYILRAQVVGVGLGMLLFFMMGSLALGSWYGSLVIRGKGASKDCSAGTVMVVFMSVLMATMSIAQVAMPINALSTAQAAAYRIYQTIDRIPDIDCRSTAGLVPTECIGNIKLEDVQFRYPTRPNKQILGGLDLEIKKGETVALVGASGCGKSTTIQLVQRVYDPVGGKVTLDGNDLRELNLKWLRNQIGLVGQEPILFACTIRENIMLGAKDGETPTEEEMIECAKMANAHEFISHLPEGYDTMVGERGAALSGGQKQRIAIARALIRKPTILLLDEATSALDTQSEKIVQQALEKASQGRTTIIVAHRLTTVRNANRICVFHQGEIIEQGTHQELMDLKATYYGLVKRQSMEEEVDQETVENDLKKFREQEDKEAEQGILHKEESSTLESSDVVERLTKEYEAETKYLKHSNRFVLLRVLLNNFRHEWLLSFLGLIGGIGAGAVFPFYMIQFIGLLMTLMGMSPDVEPTTEQLHTVRNKCIWILLFGLAVFVTTYMYLGLFLSAGEKMIVRLRKLLYSALLRQNISYYDRKENMVGKVTTRLASDPTTLKGISGERVGNVVNTLSSVGFGVGIAFYYDWKVALCVMAIAPVLIVIVFLNGKLNSIQSSPATAAYEQSGITLVEAVESIKTVQSLTREDFFYNKFAADLKRPKKNILRWGPTLAFVSAANTFVTSCISAYSFYIGTYLIKKKSDYNMEFLPFTAQFMDSFTKMQKAMMSIMMAANSCGNLGQMIPDVGKAIEAAKNTFDVLDRKPSIDCYSEEGETFNDVKGEIEFKDICFRYPTRPDNAVLKGISFKAEQGKTIALVGASGCGKSTSIQLIERFYDPTYGDVLLDGHNIKDLNIHFLRSQIGMVGQEPVLFAESVIDNIRRGVPKGVEVSNEQIYAAAKMANAHDFISAMPEGYNTMVGDRGAQISGGQKQRIAIARALIRNPKVLLLDEATSALDSESEKIVQDALDKAAKGRTTIVIAHRLSTIQNADQICVIMRGKIAERGTHQELIDLKGFYYTLAMQQFGTV
What is the function of this protein?
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug resistance parasites.
What are the official names of this protein?
Multidrug resistance protein 3, P-glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Protein: NUSB_CAMJJ
Sequence: MATRHQVRQSVISLLYAFELNSQNNVFVDEILDEKKIRNEQKNFTLNLYHGILDNLNNIDETLNSFLNDNQITALGHVERAILRLGAYELLFTDTPSAIVINEAIELAKELANDNSPKFINGVLDALIKAKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: EAF6_DROME
Sequence: MSSPTSKNVSETNGNKPKKSAKTSSNTKGGSMDTRAELADLIKKKAETSEQLANLERQIYAFEGSYLEDTQLCGNIIRGWERYLTSNKATNSKADKRNRKFKEAERLFSKSSITSMAICNPERASESDSITNEDSSDNQISINQNTTTAHDGTTTIKSTPKDEKDSPSHRNEGSVVSGMVSGSTNSGGNKDLLGTPTSNTKSKLSTNSSATAKKSGHINKKIRHR
What is the function of this protein?
Component of the Enok complex which has a histone H3 acetyltransferase activity (PubMed:27198229).  Might be involved in transcriptional activation of selected genes (PubMed:33926075).
What are the official names of this protein?
Chromatin modification-related protein MEAF6, Esa1-associated factor 6.
What is the protein family that this protein belongs to?
Belongs to the EAF6 family.
Protein: AMPA_ECOL5
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPP_ECOLI
Sequence: MKATKLVLGAVILGSTLLAGCSSNAKIDQLSSDVQTLNAKVDQLSNDVNAMRSDVQAAKDDAARANQRLDNMATKYRK
What is the function of this protein?
An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm (PubMed:29257832).  The only protein known to be covalently linked to the peptidoglycan network (PGN) (PubMed:4261992, PubMed:3013869, PubMed:4245367).  Also non-covalently binds the PGN (PubMed:3013869).  The link between the cell outer membrane and PGN contributes to the maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane (PubMed:4261992, PubMed:3013869, PubMed:4245367, PubMed:4565677).  The most abundant cellular protein in terms of copy number, there can be up to one million Lpp molecules per cell (PubMed:24766808).  About one-third of Lpp is bound to the PGN (called bound or periplasmic) the rest is called free or transmembrane (PubMed:4565677).  The 'free' form can be surface labeled by membrane impermeable agents and so must cross the outer membrane; it is thought that this transmembrane form is still anchored in the inner leaflet of the outer membrane (PubMed:21219470).  Modeling suggests that non-covalent binding of OmpA (from the outer membrane) and TolR (from the inner membrane) to peptidoglycan maintains the position of the cell wall in the periplasm, holding it approximately equidistant from both the inner and outer membranes.  Trimeric Lpp controls the width of the periplasm, adjusts its tilt angle to accommodate to the available space, and can compensate in part for an absence of OmpA (Probable).  The role of the cell surface-exposed, free form (transmembrane) of Lpp is unknown (PubMed:21219470).
What are the official names of this protein?
Major outer membrane lipoprotein Lpp, Braun lipoprotein, BLP, Murein-lipoprotein.
What is the protein family that this protein belongs to?
Belongs to the Lpp family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side. Secreted, cell wall; Peptidoglycan- anchor. Cell outer membrane; Lipid-anchor; Extracellular side. Note=Attached via its lipidated N- terminus to the inner leaflet of the outer membrane (PubMed:4575979). Attached to the peptidoglycan network (PGN) via its C-terminus (PubMed:4261992, PubMed:4245367) (Probable). About one-third of the protein links the outer membrane and the PGN, the rest is not-linked to PGN. PGN-bound and non-bound forms can interconvert (PubMed:4565677). The C-terminus of the non-PGN-bound form is exposed on the cell surface; its N-terminus is probably anchored in the inner leaflet (PubMed:21219470). Targeted by the SRP/Sec/YidC pathway (PubMed:15140892).
Protein: PYR6_ASPFU
Sequence: MATAQSPTQLVRTLIDVSRFDKYNCLFAIFPGVWSIFLAAASRHADGVHLPSDWVLGRAGLAFAYTYLLSGAGMVWNDWIDRDIDAQVARTKNRPLASGRLATRAAIIWMLVQYAASVWLMDRMLSGQNLWTFMLPLTTGIILYPFGKRPTTRKLGIYPQYILGASSALTILPAWASVYGDSVAPPDLLAKCLPLCVFLFLWTIYFNTAYSYQDVKDDCRLSVNSSYVLAGQYVHGLLLLQAVAVVMVIPWILHENGSAWLWFSWLGVWTAALAEQLYLFDTKDPSTGGRVHRRNFALGIWNVLACFVELLLVSGSLDMF
What is the function of this protein?
Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl-coenzyme A:cholesterol acyltransferase 2 inhibitor (PubMed:20861902).  The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1 (PubMed:20861902).  Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO (PubMed:20861902).  The next steps consist of an epoxidation of farnesyl-HPPO to epoxyfarnesyl-HPPO by FAD-dependent monooxygenase pyr5 and a cyclization of the terpenoid portion by the terpene cyclase pyr4 to yield deacetyl-pyripyropene E (PubMed:20861902).  The 2 cytochrome P450 monooxygenases pyr3 and pyr9, and the 2 acetyltransferases pyr7 and pyr8 are involved in the conversion of deacetyl-pyripyropene E into pyripyropene A through several cycles of oxidation and acetylation steps (PubMed:20861902).  Pyr7 acetylates deacetyl-pyripyropene E to pyripyropene E which is oxidized to 11-deacetyl-pyripyropene O by pyr3, which is in turn acetylated into pyripyropene O by pyr8 (PubMed:21224862, PubMed:26019565).  Pyripyropene O is then oxidized to deacetyl-pyripyropene A by pyr9 (PubMed:21224862).  Deacetyl-pyripyropene A is finally acetylated to pyripyropene A by pyr8 (PubMed:26019565).
What are the official names of this protein?
Polyprenyl transferase pyr6, Pyripyropene synthesis protein 6.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ASTB_SHEDO
Sequence: MKHFEANFDGLVGPTHNYAGLSFGNVASYSNAAQTANPKAAAKQGLQKAKALADLGMTQGVLAPQERPDLYTLRRIGFSGSDAEVIQKAAKQAPALLNACCSASSMWTANAATVSPSADTRDGKVHFTPANLVDKLHRSIEPITTANILKATFKDPHFFQHHAHLPEHAHFGDEGAANHTRLCGEYGHSGVELFVYGQEATNPNAPKPKKYPARQTLEASQAIARLHQLEDESTVFMQQNPDVIDQGVFHNDVISVGNQNVLFYHEQAFLNTDAKFDEIRRKMNADMHFVKVATSQVSIDDAVKSYLFNTQIITLPSGEMTIIAPTDCQENLAVFAYLNELVTLGTPIKQVRYYDVKQSMQNGGGPACLRLRVALNDQELAAVNQDTLMNDALFGRLNTWVEKHYRDSLSVKDLADPQLIVESRTALDELTQILKLGSVYQFQK
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: RL19_STRPC
Sequence: MNPLIQSLTEGQLRSDIPNFRPGDTVRVHAKVVEGTRERIQIFEGVVISRKGQGISEMYTVRKISGGIGVERTFPIHTPRVDKIEVIRHGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: EPHA8_RAT
Sequence: RIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLREAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGMLKGVGAGMRYLSDLGYIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFSHVVSVLEALVHSPESLRATATVSRCPAPAFARSCFDLRAGGNGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLHMNAQDVRALGITLMGHQKKILGSIQTMRSQLSCTQGPRRHL
What is the function of this protein?
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation.  With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth.  During development of the nervous system also plays a role in axon guidance.  Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
What are the official names of this protein?
Ephrin type-A receptor 8, EPH- and ELK-related kinase, Tyrosine-protein kinase receptor EEK.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes.
Protein: SGO1_CANGA
Sequence: MSNLYSAGTPHIQELQNILDSQQEEWAAIKENYTTQNSLIAKENCTLKMKLSELENKVSQLIRENVQLRSQVSLNKLEFQNKLASQINVLENGVIQRLEEVLYMFDSIRKKESLPSRPTSTNETVDRIKKRRQSNEEARNRRRSRSVSTGSAHSTSSMKRRSSTFGEDLIDASIKRALDNAQSNSLQTSDTLRLSELPGLNEIDTNNVNNDNLLSPIPHKKRKSNRRKSIYVPELPKPNNEPLMENTIEQQENICSESLIQEGEQSEKLGENLDADQSHVEDQSFSFTNSVLEYSIPEENTLPKQDILDETEKRDTAVNQKKKLEIFHDPPVEELSSSKNEKPPENSITNDPAFITVTGNNKVKHSMKSRKPKKNKGSVDESMPCTQSTESVDFDRPRRTRGKTVDYRLPSLRAKMRRPTEKLVDATTTVNIQDLQVKYKKSKKVLEKELKTDMKAMKSPKKNEKTFESGTIFKKISRDNESRPSSTHSTSSVDAECSHNNSHSENINSSINDTTHSSFNNSTKSVLSDITNISKNKQQQKTKKLLKTAIINDIYDDKTKNAQKTVSFRVNEDDLSVFDLIQHNDTNKSSPKTYRSRSRKNKA
What is the function of this protein?
Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.
What are the official names of this protein?
Shugoshin.
What is the protein family that this protein belongs to?
Belongs to the shugoshin family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere.
Protein: CYB6_SPIOL
Sequence: MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTDAFASVQYIMTEVNFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLGVLTASFGVTGYSLPWDQIGYWAVKIVTGVPDAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFLMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: MED21_CANAL
Sequence: MADRLTQLQICLDQLIQQFNSTINYVNTSAEPSLLDDDDVNSYSNMAANAPLPQSQQQRQQQKKQQEPQQEIEQPQQQSNPESKSISPPKEKVSFDNVINELCTDLILKSRQIKMLIDSLPGIGVTPNEQMNLINELSDKLQAIEEERIQKIKEKDNLLNLLESMIKEVVNGITETRI
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPE_HISS2
Sequence: MKNNIITLTQSLIQRPSISPDDQGCQQLIAERLQAVGFKLEWLPFGDTLNLWATHGEGKCIAFAGHTDVVPIGNESQWTYPPFEARIVENMLYGRGAADMKGALAAMVIAAETFVKHLPNHQGKIALLITSDEEAAATNGTVKVVETLIKRNEKIDYCVVGEPSSATQFGDIIKNGRRGSITGNLYIQGVQGHVAYPHLADNPVHNALKFLDELTHYQWDKGNEFFPPTSLQIANIHAGTGSNNVIPGELYVQFNLRYCTEVTDEIIKTKVAEMLEKHKLTYRIDWNLSGKPFLTPQGKLVNATIEAVKKFTQIRPHLDTGGGTSDARFIATMGAEVVEFGPLNQTIHKVNECVNIDDLAKCGEIYYYILEKLFNEQ
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: ATPA_PHAAO
Sequence: MGTLRADEISNIIRERIEQYNREVKIVNTGTVLQVGDGIARIHGLDEVMAGELIEFEEGTIGIALNLESNNVGVVLMGDGLMIKEGSSVKATGRIAQIPVSEAFLGRVINALAKPIDGRGEISSSESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQKGQNVICVYVAIGQKASSVAQVVTTFQEGGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYRERHTSIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSRLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKSKLELAQFAELEAFAQFASDLDKATQNQLARGQRLRELLKQSQSDPLAVEDQIATIYTGTNGYLDALEIGQVKKFLVGLRTYLTKKKPKFQEILSSTKIFTEEAETLLREAIQEQIELFLLQEQT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: PLSX_SALA4
Sequence: MTRLTLALDVMGGDFGPSVTVPAALQALNANSQLTLLLVGNPDIITPLLAKADFEQRSRLQIIPAQSVIASDARPSQAIRASRGTSMRVALELVKEGRAEACVSAGNTGALMGLAKLLLKPLEGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLVQFAVMGAVLAEEVVGIKNPRVALLNIGEEETKGLDSIREASLMLKTVPTINYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKRSWWLLLLKRWLQKSLTRRFSHLNPDQYNGACLLGLRGTVIKSHGAANQRAFAVAIEQAVQAVQRQVPQRIAARLESVYPAGFEPLDDGKGVNLRAHR
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RECU_STAAU
Sequence: MNYPNGKPYRKNSAIDGGKKTAAFSNIEYGGRGMSLEKDTEHSNTFYLKSDIAVIHKKPTPVQIVNVNYPKRSKAVINEAYFRTPSTTDYNGVYQGYYIDFEAKETKNKTSFPLNNIHDHQVEHMKNAYQQKGIVFLMIRFKTLDEVYLLPYSKFEVFWKRYKDNIKKSITVDEIRKNGYHIPYQYQPRLDYLKAVDKLILDESEDRV
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates in genetic recombination.  Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands.  Promotes annealing of linear ssDNA with homologous dsDNA.  Required for DNA repair, homologous recombination and chromosome segregation.
What are the official names of this protein?
Holliday junction resolvase RecU, Penicillin-binding protein-related factor A homolog, PBP-related factor A homolog, Recombination protein U homolog.
What is the protein family that this protein belongs to?
Belongs to the RecU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NFRA_STAES
Sequence: MSDYVYELMKQHHSVRKFKNQPLGSETVEKLVEAGQSASTSSYLQTYSIIGVEDPSIKARLKEVSGQPYVLDNGYLFVFVLDYYRHHLVDEVAASNMETSYGSAEGLLVGTIDVALVAQNMAVAAEDMGYGIVYLGSLRNDVARVREILNLPDYTFPLFGMAVGEPSDEENGSPKPRLPFKHIFHKDQYDANQHQQRKELEAYDQVVSEYYKERTNGVRTENWSQQIETFLGRKTRLDMLDELKKAGFIKR
What is the function of this protein?
Reduces FMN, organic nitro compounds and disulfide DTNB.  Involved in maintenance of the cellular redox state and the disulfide stress response (By similarity).
What are the official names of this protein?
NADPH-dependent oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the flavin oxidoreductase frp family.
Protein: PAAJ_ECOLX
Sequence: MREAFICDGIRTPIGRYGGALSGVRADDLAAIPLRELLVRNPRLDAECIDDVILGCANQAGEDNRNVARMATLLAGLPQSVSGTTINRLCGSGLDALGFAARAIKAGDGDLLIAGGVESMSRAPFVMGKATSAFSRQAEMFDTTIGWRFVNPLMAQQFGTDSMPETAENVAELLKISREDQDSFALRSQQRTAKAQSSGILAEEIVPVVLKNKKGVVTEIQHDEHLRPETTLEQLRGLKAPFRANGVITAGNASGVNDGAAALIIASEQMAAAQGLTPRARIVAMATAGVEPRLMGLGPVPATRRVLERAGLSIHDMDVIELNEAFAAQALGVLRELGLPDDAPHVNPNGGAIALGHPLGMSGARLALAASHELHRRNGRYALCTMCIGVGQGIAMILERV
What is the function of this protein?
Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA.
What are the official names of this protein?
Beta-ketoadipyl-CoA thiolase, 3-oxoadipyl-CoA thiolase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
Protein: RL13_PSET1
Sequence: MKTFVAKPETVKRDWYVVDAEGKTLGRIATEIALRLRGKHKVEYTPHVDTGDYIIVINAEKVTVTGNKFKNKVYYSHSGFPGGLKSTTFDKLQAAKPEMIIEKAVKGMLPRGPLGRAMYRKLKVYTGTEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PYRF_AQUAE
Sequence: MARICVALDVPWERAIKIVKDLYDFFETYPLILKIGHKIYLEKGGDAVKELKEDFPYEVFLDLKLHDIPSVVGLAVEKISELGTDYTTVHLLGGPEMVKEAVKNKGSMKILGVTILTSHDENYIKFLKSNFEDIKNFTLYLARVGIENGVDGVVCSGEEVEFLKKNIEKDFIAVVPGIRIKKEKRHDQKRVLTPAEAKKRGADVIVIGREITESKNPVYVVERALKMMGEI
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: HFLD_ECOSE
Sequence: MAKNYYDITLALAGICQSARLVQQLAHQGHCDADALHVSLNSIIDMNPSSTLAVFGGSEANLRVGLETLLGVLNASSRQGLNAELTRYTLSLMVLERKLSSAKGALDTLGNRINGLQRQLEHFDLQSETLMSAMAAIYVDVISPLGPRIQVTGSPAVLQSPQVQAKVRATLLAGIRAAVLWHQVGGGRLQLMFSRNRLTTQAKQILAHLTPEL
What is the function of this protein?
Negative regulator of phage lambda lysogenization.  Contributes to the degradation of the phage regulatory protein CII.  Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease.
What are the official names of this protein?
High frequency lysogenization protein HflD.
What is the protein family that this protein belongs to?
Belongs to the HflD family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MRAY_ACISJ
Sequence: MLLMLTQWLQGLSPELSFLRVFQYLTLRAVMAALTALLIGLIAGPKVIRMLTSLKIGQPIRGYAMQTHLSKSGTPTMGGVLILGSIAISTLLWFDLSNRFVWIVLAVTLGFGAIGWVDDWRKVVNKDPEGMRSREKYFWQSVIGLLAALYLVFSISENSNTRVFELFITWVQSGFLMDLPPKAGLLVPFFKEVSYPLGVLGFVILTYLVIVGSSNAVNLTDGLDGLAIMPVIMVGASLGIFAYVTGNAGYAKYLLFPYIAGSGELLIFCAAMAGAGLAFLWFNTHPAQVFMGDVGALALGAALGTIAVIVRQEIVLAIMGGIFVVEALSVMLQVTWFKYTKRKYGEGRRLLKMAPLHHHFEKSGWKETQVVVRFWIITMLLCLVGLTTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.