PharMolix/UniProtQA huggingface dataset:
Protein: PBIR1_MOUSE
Sequence: MAQEKMELDLELPAGASPAEGGGPGGGGLRRSNSAPLIHGLSDSSPVFQAEAPSARRNSTTFPSRHGLLLPASPVRMHSSRLHQIKQEEGMDLINRETVHEREVQTAMQISHSWEESFSLSDNDVEKSASPKRIDFIPVSPAPSPTRGIGKQCFSPSLQSFVSSNGLPPSPIPSPTTRFTTRRSQSPINCIRPSVLGPLKRKCEMETDYQPKRFFQGITNMLSSDVAQLSDPGVCVSSDTLDGNSSSAGSSCNSPAKVSTTTDSPVSPAQAASPFIPVDELSSK
What is the function of this protein?
Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity.  Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (By similarity).  Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (By similarity).
What are the official names of this protein?
P2R1A-PPP2R2A-interacting phosphatase regulator 1, PABIR family member 1.
What is the protein family that this protein belongs to?
Belongs to the FAM122 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=The CHEK1-mediated Ser-34 phosphorylated form is sequestered by 14-3-3 proteins in the cytoplasm and fails to translocate to the nucleus, where it otherwise inhibits serine/threonine-protein phosphatase 2A.
Protein: PELP1_XENLA
Sequence: MEVTIAGILERDLSEGELAEAIRGLREHGAFRGEGLPAAMSGLLSSCNSRLTSASSRIEGLSLLALAVEESPTDVFVQHCVSWLRSLLQIIQSQDPPRVVSLAVFVLRSLLAHSSALPELSREISTNHIPGLLTSLLGLRRQCLVPALEGIRSCFLSYPRACGSLRGKLTAFLLSLLDAENQQIQEVACQCYSLLPSLGSGFSQGIKHTENWERQIQSVICSLHSVFLQLYQGSETDTARYEGSGTELEFPSVEDDGTHGVLQLARRFTALGQCMRLLLREQFPAPVRVPVSDILSLVCRVVNVSPKNLSWHGEESLKLLLLPRVHSSILEILEATIIACGPRLLPFSAVICRLFPQLLLSWAAVKGITGIPSGQERPYSSLRCSVYRVLETWVTTCGISSGVLQGPMHHSDILLANLLSDITPPTDAIKMSTFVQLGAKKQKVSEVGDDDFQSHRKRDNTANVELCAAALKGLCCVILHCGSVIKEDVHRRLQELSIPLLLRLQQGSDQWLGPYISSDCRKELYRLLLCLTLTPNPKLPAPLHCAIRIFRGGTTEESLQVSRFSTEALAICRILIHPRVPSLQRPLPHLAPRPSVQSDAPTLRPPAALSTFPAMPPANHLPPRPTVPAMSTEPPIPAAVPSPPPEESFGEKPRRAVFIHFDKEEPSDVEISLESDSDDSVVIVPEGLFAKSDSKPEPSPPAVKPPTEEVTEQVAPSAVPSSSTAAPPPPPPPPAPPVCAGPSSAPVPIAEAPPPPQQEVDTVININSSDDEEDGEEDEEEGLYDDEDEEDYYDEEEDEDLEGLEEDDYDYEEDEEGITEEEEEDLEEEGEDDEEEVEDEECLMPDEMQIGSEAEEIPDGIETSSLHEGELEEGPPRLSPVQEDEAVDTGLLMLVESEDREPSGEAPGEGLPESDLTRSPPQPPVLTPPSPPDEPPPMEESDVPPLEEPDLEVAPVAEEPVEETEEKKPEEVTVEKPEPEPEEEEQIADADAMLADFVDCPPDDDKLPEPCT
What is the function of this protein?
Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors.  Regulates oocyte maturation.  Enhances androgen receptor (AR)-mediated transcription in a SRC-dependent manner.
What are the official names of this protein?
Proline-, glutamic acid- and leucine-rich protein 1, Modulator of non-genomic activity of estrogen receptor.
What is the protein family that this protein belongs to?
Belongs to the RIX1/PELP1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MOBA_SHESM
Sequence: MSLQIDAVILAGGMARRMGGDDKGLVELNGKAMIEHTIERIKPQVKEILINANRNQTRYAEFGFTVLSDEHTGFLGPLAGMITAMGHTQADYLLVVPCDCPLLPRDLVARLLAAIKANDAELAVASDGEREQPVVMLLKPSLRESMTAFLEAGERKIDFWYAKHRFAVAAFADQPNAFVNVNTPEQKQRLAAEINQS
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDS3_HORVU
Sequence: MENILHATPAHVSLPESFVFASDKVPPATKAVVSLPIIDLSCGRDEVRRSILEAGKELGFFQVVNHGVSKQVMRDMEGMCEQFFHLPAADKASLYSEERHKPNRLFSGATYDTGGEKYWRDCLRLACPFPVDDSINEWPDTPKGLRDVIEKFTSQTRDVGKELLRLLCEGMGIQADYFEGDLSGGNVILNINHYPSCPNPDKALGQPPHCDRNLITLLLPGAVNGLEVSYKGDWIKVDPAPNAFVVNFGQQLEVVTNGLLKSIEHRAMTNSALARTSVATFIMPTQECLIGPAKEFLSKENPPCYRTTMFRDFMRIYNVVKLGSSLNLTTNLKNVQKEI
What is the function of this protein?
Involved in the biosynthesis of mugineic acid family of phytosiderophores.  Hydroxylates the C-2' positions of 2'-deoxymugineic acid (DMA) and 3-epihydroxymugineic acid (epiHDMA).  May be involved in boron tolerance.
What are the official names of this protein?
2'-deoxymugineic-acid 2'-dioxygenase, Protein iron deficiency-specific 3.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOP1_CAEEL
Sequence: MPRTKRVYSGKTITGVLYPVAICMLFVAINVKLSQPEQQEQSKVVYGLFHSYDTADSGTITLYLIGFLILTTSLGVFCYQMKFYKAIKVYVLANSIGILLVYSVFHFQRIAEAQSIPVSVPTFFFLILQFGGLGITCLHWKSHRRLHQFYLIMLAGLTAIFILNILPDWTVWMALTAISFWDIVAVLTPCGPLKMLVETANRRGDDKFPAILYNSSSYVNEVDSPDTTRSNSTPLTEFNNSSSSRLLESDSLLRPPVIPRQIREVREVEGTIRLGMGDFVFYSLMLGNTVQTCPLPTVVACFVSNLVGLTITLPIVTLSQTALPALPFPLAIAAIFYFSSHIALTPFTDLCTSQLILI
What is the function of this protein?
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1).  Probably works redundantly of lin-12, which provides more presenilin function.
What are the official names of this protein?
Presenilin hop-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RL29_CLOBK
Sequence: MKARELQELRKSSPQELQSKLNDLKAELFNLRFQLATGQLENPMRIREVKKSIAQIKTILREEEIRAYQQ
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: NUOC_GEOUR
Sequence: MADMAENNRAVIKLREKFASSILEVKEFRGEVTVIVRKEDIVALCKFLKEELRYNLLTDVTAVDYLGKDPRFMVVYNIYSIPNKDRLRIKAPVTEGECTIDTVCGVWTTANWLEREAYDLMGIIFKNHPDLRRIMMTDDWVGHPLRKDYPLQGPDREPYKGRLS
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS11_VESOH
Sequence: MIAKSSSKKKSKKVITDGIAHIHATFNNTIVMITDRHGNTVCWATSGGSGFRGSRKSTPFAAQVAAGSCGEKALAFGMKNLEVHVKGPGPGRDSAIRGLNAQGLKIQSITDVTPIPHNGCRPSKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: 3S14_AIPLA
Sequence: MKTLLLTLVVVTIVCLDLGYTLTCCNQQSSQPKTTTDCADDSCYKKTWKDHRGTRIERGCGCPQVKPGIKLECCKTNECNN
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Short neurotoxin D.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRR_STRPN
Sequence: MKTKEVVDELTVKRAITRITYEIIERNKDLNKIVLAGIKTRGVFIAHRIQERLKQLENLSVPVVELDTKPFRDDVKSGEDTSLVSVDVTDREVILVDDVLYTGRTIRAAIDNIVGHGRPARVSLAVLVDRGHRELPIRPDYVGKNIPTSRSEEIIVEMTELDDQDRVLITEEA
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: AMP3_COCNU
Sequence: YCSYTMEA
What is the function of this protein?
Has antimicrobial activity against Gram-positive bacteria B. subtilis (MIC=257 ug/ml) and S. aureus (MIC=274 ug/ml), and against Gram-negative bacteria E. coli (MIC=302 ug/ml) and P. aeruginosa (MIC=259 ug/ml).
What are the official names of this protein?
Antimicrobial peptide 3, Cn-AMP3.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: ATPF_SHEB9
Sequence: MNFNATLIGQTVAFIIFVWFCMKFVWPPLMNAIEERQKRIADGLADADRAVKDLELAQAKATDQLKEAKVTANEIIEQANKRKAQIVEEAKTEADAERAKIIAQGKAEIEAERNRVKEDLRKQVATLAIMGAEKILERSIDPAAHSDIVNKLVAEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: Y2311_MYCTU
Sequence: MAPTGQAVDVAVREGAGDVGYSVERENLPADDPVRNGNRWRVIAVDTEHHRIAARRLGDGARAAFSGDYLHEHITHGYAITVHASQGTTAHSTHAVLGDNTSRATLYVAMTPARESNTAYLCERTAGEGARVDLAGWDLWVSGKAEAMSDEKSASPVWCRVGARCDHRGKRSCW
What are the official names of this protein?
Uncharacterized protein Rv2311.
Protein: B2L15_BOVIN
Sequence: MSPRTFEEQTECIVNALLTDFLGPAWEVGNRTLQCEDESDSGEVSSFDVAIIAGRLRMLGDKFNGELEASAKNVIAETIRGQAGIVLQNTVKSLSNAWCAQDSSLAYERAFLAVSVKLLEHVARMAPEVARQVVRPITNMINGNTAIREYIQGQGGWENLEG
What are the official names of this protein?
Bcl-2-like protein 15, Bcl2-L-15.
Protein: CO1A2_HUMAN
Sequence: MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK
What is the function of this protein?
Type I collagen is a member of group I collagen (fibrillar forming collagen).
What are the official names of this protein?
Collagen alpha-2(I) chain, Alpha-2 type I collagen.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: MIAB_ECO7I
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGSFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_CHLT2
Sequence: MKILIASSHGYKVRETKAFLKKLGEFDIFSLVDYPSYQPPKETGETPEENAIQKGLFAAQTFRCWTIADDSMLIIPALGGLPGKLSASFAGEQANDKDHRKKLLENMRLLENTIDRSAYFECCVALISPFGKIFKAHASCEGTIAFEERGSSGFGYDPLFVKHDYKQTYAELPEAIKNQVSHRAKALVKLQPYVETVLANHLLAGKESL
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: TOP3_SALTY
Sequence: MRLFIAEKPSLGRAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHQAGEIIHAGDPDREGQLLVDEVLDYLQLPAEKRQQVRRCLINDLNPQAVERAIDRLRANSDFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRINGQPALVTSYNDKRESESAPLPFSLSTLQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRQAVMNAISVHAPDLLPQPVVNPDTRNRCWDDKKVDAHHAIIPTARSSSVHLTENEAKVYTLIARQYLMQFCPDAVFRKCVIELEIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRSFLTKKGRYIHSTDAGKALIHSLPEMAARPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIEQAKRTPVKRFRGIVAPGGGDKKKSAPRKRAGKKSPPAAETGRQTE
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 3, DNA topoisomerase III.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: UBC16_SCHPO
Sequence: MNSSIKRLHKEYASFQAGDISGLLLLKPVTDVDMFHWKAVIEGPTETPYEGGQWVLDIHVHEGYPISPPSVYFQTKIVHPNISWTNGEVCMDILKTHWSPAWSLQSACLAIISLLSNYDASSPLNVDAAKLLRTGDKTAYNSLVRCTTYLYAKGKIEDLS
What is the function of this protein?
Catalyzes the covalent attachment of ubiquitin to other proteins.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 16, E2 ubiquitin-conjugating enzyme 16, Ubiquitin carrier protein 16, Ubiquitin-protein ligase 16.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: ASSY_SHEDO
Sequence: MSSTVKKTGVKKVVLAYSGGLDTSAIIPWLKETYDDCEIVAFCADVGQGEEELVGLTEKALASGASECHIVDLKEEFVKDYIYPTIATGAIYEGTYLLGTSMARPIIAKAQVEVARKVGADALCHGCTGKGNDQVRFEGCFAALAPDLKVIAPWREWEMRSREDLLAYLAARDIQTSASATKIYSRDANAWHISHEGGELEDPWNEPSKGVWTLTVAPEDAPDEAEYVALSIKHGRVTHVNEQVLSPYNALMKLNDIASKHGVGRIDITENRLVGMKSRGCYETPGGTVMFAGLRAIEELVLDKTSRTWREQVAAQMAHLVYDGRWFTPLCNSLLAASESLAEAVNGDVVIKLYKGQATAVKKRSPNSLYSESFATFGEDDVYDQKHAEGFIRLYSLASRIRAMNSN
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_RALPJ
Sequence: MKPVIALVGRPNVGKSTLFNRLTRSRDALVADIPGLTRDRHYGEGRVGDRPFIAIDTGGFEPVAKEGIVAEMAKQTRQAVVEADVVIFIVDGRLGLAPQDRVIADYLRKTGRRILLAVNKAEGMRYTAVASDFYELGLGDPAAISAAHGDGVNDLVAEALDLAFAERPELAEAADAHDHGTRIAIVGRPNVGKSTLVNALIGEERVIAFDMPGTTRDAIYVDFERNGKPYTLIDTAGLRKRGKVFEAIEKFSVVKTLQSIADANVVVLILDAQQDISDQDAHIAGFIVESGRALVIGVNKWDGLTGHARDRIKHDMERKLQFLSFANVHYISAKERTGIGALMKSVDAAYAAAMVKLPTPKLTRVLMEAVEYQQPRRAGVSRPKLRYAHQGGSNPPIVVIHGNALSNIPETYRRFLEGRFREAFQLKGTPLRIEFRTNKNPYAQSND
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: CC134_HUMAN
Sequence: MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVMLKGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVLRFPRIVHYYFDHNSNWNLLIRWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTEFIPSTDPFQKALREEEKRRKKEEKRKEIRKGPRISRSQSEL
What is the function of this protein?
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity.  May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity.  May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
What are the official names of this protein?
Coiled-coil domain-containing protein 134.
What is the protein family that this protein belongs to?
Belongs to the CCDC134 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum. Note=Accumulates in the nucleus in response to UV irradiation (PubMed:22644376).
Protein: KAIB_MICAN
Sequence: MSVFKKTYVLKLYVAGNTPNSVRALKTLKNILEEEFQGVYALKVIDVLKNPQLAEEDKILATPTLAKVLPPPVRKIIGDLSDREKVLIGLDLLYEEIRERENDS
What is the function of this protein?
A metamorphic protein which reversibly switches between an inactive tetrameric fold and a rare, thioredoxin-like monomeric fold (KaiB(fs)).  KaiB(fs) binds phospho-KaiC, KaiA and CikA.  KaiA and CikA compete for binding to KaiB(fs), and KaiB(fs) and SasA compete for binding to KaiC, thus the clock oscillator and output signal pathway are tightly coupled.
What are the official names of this protein?
Circadian clock oscillator protein KaiB.
What is the protein family that this protein belongs to?
Belongs to the KaiB family.
Protein: RS19_PSEA6
Sequence: MPRSLKKGPFIDLHLLKKVEAAVEKNDKKPIKTWSRRSMIIPDMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHVADKKAKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: SLMO_DROME
Sequence: MKIWTSEHIFNHPWETVTQAAWRKYPNPMTPSIIGTDVVERRVVDGVLHTHRLVQSKWYFPKWTHALIGTAKTCFASERSTVDPERKQMVLKTNNLTFCRNISVDEVLYYEPHPSDASKTLLKQEATVTVFGVPLSHYMEDLLTSTISTNAGKGRQGLEWVIGLINTEVKGIARGTDELLHNTRRSIDEVTESARKSMDEISAQAAKAAKAMHIT
What is the function of this protein?
Required to regulate peristaltic movement and also for germline proliferation in males and females.
What are the official names of this protein?
Protein slowmo.
What is the protein family that this protein belongs to?
Belongs to the slowmo family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DEF1_BURM1
Sequence: MANAAHRFTEYRKTMALLNILHYPDKRLHKVAKPVDKVDDRIRKLVADMAETMYAAPGIGLAATQVDVHERVIVIDVSEDKNELRAFINPEIIWSSDGKQVYEEGCLSVPGIYDEVERPDRVRVRALNEQGETFELDCEGLLAVCIQHEMDHLMGRVFVEYLSPLKQSRIKTKMKKLERAM
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 1, PDF, Polypeptide deformylase 1.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: MT1A_VICFA
Sequence: MSGCGCGSSCNCGDSCKCNKRSSGLSYSEMETKETKETVVLGFGPAKIHFDGAEMSVASKEEGCKCGDKCTCDPCNC
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-like protein 1A, MT-1A.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: H2AZ_CRYNB
Sequence: MSSKVGGGKGGKSKTSSEAKVLTTRSSKAGLQFPVGRIHRFLRNKNANNVRIGAKAAVYVASIMEYLTAEVLELAGNAAKDLRVKRITPRHLQLAIRGDEELDLLIRATIAGGGVLPHIHKSLVAKNAPLKKPKALDA
What is the function of this protein?
Variant histone H2A which can replace H2A in some nucleosomes.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.  This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received.  Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins.  Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes.  Involved in chromosome stability (By similarity).
What are the official names of this protein?
Histone H2A.Z.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: Y525_MYCPN
Sequence: MQPNYYRVIKKATSFSGLDMISHAYGQIAGVEVVGFYLWLITEANAQAFNSEIRTPISRLQNAFNTTGTKNVNVPDWIYKTIGKLESLGLVRTFFSQEKSEMTFWIVEPLGWKEFNQKKHFKEKLIESMGKLEYDRNCLSFEQIDNIQFDNALEITANFEANFTSKQDCLSFSFDFEAFHKQLVKQNLFVSFNQKTKAVINGYFEKYQITLEGILECVIPSVVNDEVDLELLQKLLEQLVKNNTAPIVDTVINDRNFFYDNQNLATETKDAISRCHLEYNAEKYLFLLYGKVENEQLDLIRRLRQEFGIADKVINLIVDFSFWKNNSMWREQYILKIAESVERYRSHNNYQATLDNFIRASSLAKKQRTKTKIEKSEPETSAAPVNETDDVNYFLNRIKAINKKNRENGKHKR
What are the official names of this protein?
Uncharacterized protein MG349 homolog.