PharMolix/UniProtQA huggingface dataset:
Protein: SRCH_RABIT
Sequence: MGCRGPWLHTCLLWAAVASLLLPPAVTQQLRGAGLGPSTWINNAGAPGPSGEAAAAGLGHHGHSHRSPGEENEDVSMENGHHFWSHRDHGETDDEVSREYGHQPQGHRYHSPEAGDESVSEEGVHREQARQAPGHGGHGEAGAEDLAEHGSHGHGHEEEDEDVISSERPRHVLRRAPRGHGGEEEGEEEEEEEEVSPEHRHRGHGKEDEEDEDDDSTESDRHQAHRHRGHREEEDEDDDDDEGDSTESDHHQAHRHRGHEEEEDEEDDDDEGDSTESDRHQAHRHRGHREEEDEDDDDEGDSTESDRHQAHRHRGHREEEDDDDDDDEGDSTESDRHQAHRHRGHREEEDEDDDDEGDSTESDRHQAHRHRGHREEEDEDDDDEGDSTESDRHQAHRHRGHREEEDEDDDDEGDSTESDHHQAHRHRGHREEEDEEDDDEGDSTESDRHQAHRHRGHGEEEDEDDDDEGEHHHVPHRGHRGHEEDDGGDDDDGDDSTENGHQAHRHQGHGKEEAEVTSDEHHHHVPDHGHQGHGDKEGEEEGVSTDHWHQVPRHAHHGPGGEEEGGEEELTVKAGHHVASHPPPGHRSREGHAEEHQTEVPGHHQHRMGDTDTSAERGHPASSPRQQGHPPEDTVHHHRGSLKEEVGPESPGPAGVKDGSRVKRGGSEEEEEQKGTHHHSLEDEEDEEEGHGRSLSQEDQEEEDRRGESAKVQAPLRHHREEEEEEEEEEEEEGRLPFTIIPNPLSGREAAGGASSEESAEDTGPEDTQEYGNYQQGSLCGYCTFCNRCTECEHCHCDEDSMGEHCDQCQHCQFCYLCPLVCETVCTPGSYVDYFSSSLYKALADMLETPEP
What is the function of this protein?
May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
What are the official names of this protein?
Sarcoplasmic reticulum histidine-rich calcium-binding protein.
What is the protein family that this protein belongs to?
Belongs to the HRC family.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum lumen.
Protein: CYNS_PSEU2
Sequence: MPHSNISRAPRQHLTERVLQAKTAKNLTWAGLAEGTGLSVVYVTAALLGQHPLPQAVAEVVAERLGLDRDAVAELQTIPLRGNVEDVSSDPTIYRFHEMVQVYGTTLKALVHEQFGDGIISAINFKLDIKKVDDPEGGERAVITLDGKFLPYKPF
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: RL6_PORGI
Sequence: MSRIGKLPISIPAGVTVSHKDEIVTVKGPKGELSQYVDPRITVVIEGGMIHLERKTDDRIERSLHGLYRSLINNMVQGVSAGFKRELELVGVGYRASNQGQLLELSLGFTHSIFMQLPKEVTVETKSERNKNPLIILESADKQLLGQVCMKIRSFRKPEPYKGKGVKFVGEQIRRKSGKSAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: ACTTR_ALTAL
Sequence: MLQCAPKKNERLRGSCDFCTQSKLRCNKNKPSCRRCTIQQQPCVYSVARRTGRPPKRPRKANDGQEANEQHGDQDPVTSTPGGSCQQQSNHLLDVEGDGANFTLADASTTAQDRETAACTALDNALLMGGTFGFSSLLDDPLIQSDDFLSFSLCMPPGEEEGHMASPCSPPILPSIDVPHLPARFGFLESSVESGLHGRNGPHLIEQPDKTVPSSFSEMEKIYDEGLTFSGLDSAINAVTNNGKGEPSIPGTMAAHPHSKRQCFCSTSMSKLQMLVSHPTLCQKNSRARFDMTLFLEEVVFSIYRDVLQCLVCQSKSLHSLASLCICTDWVIEALRDVAQDLSSGQDNLGGFRAGLCPPKDKFSICVGRFVLDDQLRESCTRSLVRYRLRKLIPIMDTMMKLNYRGAGGALSQAIRTMVEDVRHKIESALGMMEL
What is the function of this protein?
Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) ACT-toxins responsible for brown spot of tangerine disease by the tangerine pathotype which affects tangerines and mandarins (Probable).  ACT-toxins consist of three moieties, 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA), valine and a polyketide (PubMed:22846083).  ACT-toxin I is toxic to both citrus and pear; toxin II the 5''-deoxy derivative of ACT-toxin I, is highly toxic to pear and slightly toxic to citrus (PubMed:22846083).  On cellular level, ACT-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).
What are the official names of this protein?
Transcription activator ACTTR, ACT-toxin biosynthesis regulator.
What are the subcellular locations of this protein?
Nucleus.
Protein: HUTU_XANAC
Sequence: MTRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAERPQELVVYGGIGRAARDWESFDAIVAALTRLDEDHTLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFNELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYDGNLAGKWLFTGGLGGMGGAQPLAAVMAGASCLAVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTARKPLSVGLLGNVADVLDELLLRGIRPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSAPKEVEAAARDSMANHIRAMLTFHALGVPTVDYGNNLRQMALEAGVDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAADKIAFQGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIATDCAKAKGLDLPGILR
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_AZOSB
Sequence: MNLNATLIAQLVVFFILAWFTMKFVWPPIVKALDERAKKIADGLAAADKAKADLALAEKKVVEELRKARESAGDVRASAEKQASQLVDEARAEASRIIAQAREAAEAEAGAAAQRAKEALRDQVAHLAVAGAEKILRREINAQVHAELLANLKQELQ
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PP120_ARATH
Sequence: MGPPLLPKHVTAVIKCQKDPMKALEMFNSMRKEVGFKHTLSTYRSVIEKLGYYGKFEAMEEVLVDMRENVGNHMLEGVYVGAMKNYGRKGKVQEAVNVFERMDFYDCEPTVFSYNAIMSVLVDSGYFDQAHKVYMRMRDRGITPDVYSFTIRMKSFCKTSRPHAALRLLNNMSSQGCEMNVVAYCTVVGGFYEENFKAEGYELFGKMLASGVSLCLSTFNKLLRVLCKKGDVKECEKLLDKVIKRGVLPNLFTYNLFIQGLCQRGELDGAVRMVGCLIEQGPKPDVITYNNLIYGLCKNSKFQEAEVYLGKMVNEGLEPDSYTYNTLIAGYCKGGMVQLAERIVGDAVFNGFVPDQFTYRSLIDGLCHEGETNRALALFNEALGKGIKPNVILYNTLIKGLSNQGMILEAAQLANEMSEKGLIPEVQTFNILVNGLCKMGCVSDADGLVKVMISKGYFPDIFTFNILIHGYSTQLKMENALEILDVMLDNGVDPDVYTYNSLLNGLCKTSKFEDVMETYKTMVEKGCAPNLFTFNILLESLCRYRKLDEALGLLEEMKNKSVNPDAVTFGTLIDGFCKNGDLDGAYTLFRKMEEAYKVSSSTPTYNIIIHAFTEKLNVTMAEKLFQEMVDRCLGPDGYTYRLMVDGFCKTGNVNLGYKFLLEMMENGFIPSLTTLGRVINCLCVEDRVYEAAGIIHRMVQKGLVPEAVNTICDVDKKEVAAPKLVLEDLLKKSCITYYAYELLFDGLRDKRLRKKKGFTVVAI
What are the official names of this protein?
Putative pentatricopeptide repeat-containing protein At1g74580.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: KDPA_DECAR
Sequence: MSNHAWILLGIFLVVLLLTVKPLGTYIANVMEGRFRLAGKIESPIYRLCGIRPDEEMGWLKYACAILLFNVLGVLAVYALQRLQAELPLNPQVFPAVSPDSAFNTAISFATNTNWQGYVGEATMSYLTQMLALAVQNFFSAATGIVVVIALIRGFARHTAKTFGNAWVDLTRITLHVLLPISIIYAVFLTGQGVIQNFNAYKDVTTLEVTSFDNPKLDDAGQPLKDDKGAVVTEPAQTQTQTLAMGPVASQEAIKMLGTNGGGFMNANSAHPYENPTPLSNFIQMLSIFLIPAALCFTFGRIVGDTRQGWAVLAAMTLMFVALAYTAMHFEQQANPLLTQLGVDPASGNMEGKETRFGIGDSGLFATITTLASCGAVNAMHDSFTPLGGLVPLIDMQLGEVVFGGVGTGLYGMLVFAIMAVFIAGLMIGRTPEYLGKKIEAFEMKMVSIAILVTPLLVLVGTAIAVMLADGKAGIANPGAHGFSEILYAFTSAANNNGSAFAGLSANTPFYNVMLGIAMWFGRFGVIVPVLAIAGSLAAKKRIAVGAGTLPTHGPLFVTLLIGTVLLVGLLNYVPALALGPVIEHLVLWAAH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPD_BREBN
Sequence: MLTYALEQILLGKHLTRTVAEEAMGEIMDGKATPAQIGAFLASLRLKGEQVEEIIGFAKAMRARAMNFPIELPGLVDTCGTGGDGSHTFNISTASAVVAAADGVRIAKHGNRAVSSKSGSADVLEALGVPVNLSPKDAADCLRATNLCFLFAPLYHQAMKHAAGPRKELAIRTVFNLLGPLTNPAGASHQLMGVYDAKLLPNVAAVLHELDVKRALVVAGSDGLDELTVTGTSHIAELRDGRILTYEIEPEQFGLRRHEKDALRGGDANENAKIIHDVFSGARGAARDIVLLNAGAILYLADRVSSIETGVIRAAELIDGGLVMRKLEHVRHIAGGMIHAS
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: SUH3_RAT
Sequence: MMSDYTWFEGIPFPAFWFSKEILENSCKKFVVKEDDLIILTYPKSGTNWLIEIVCLIQTKGDPKWIQSMPIWDRSPWIETGSGYDKLTKMEGPRLMTSHLPMHLFSKSLFSSKAKVIYLIRNPRDVLVSAYFFWSKIALEKKPDSLGTYVEWFLKGNVAYGSWFEHIRGWLSMREWDNFLVLYYEDMKKDTMGSIKKICDFLGKKLEPDELNLVLKYSSFQVVKENNMSNYSLMEKELILTGFTFMRKGTTNDWKNHFTVAQAEAFDKVFQEKMAGFPPGMFPWE
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics.
What are the official names of this protein?
Alcohol sulfotransferase, Hydroxysteroid sulfotransferase, ST, ST-60.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIC19_YEAST
Sequence: MGSNTSKVGAGAEKQQVYTPLTQIDFSQSLVSQLDSSKESDYVTKQNAEKFIEKKVSQRLSNLEVETLKKFEDTLNNSLLSDDDKDAVDGISSSSLNNQIESLNKKLTLFDQLELQKLEKYGGAKGKSDKKTDNGSISIKAKLTECLLANKGKPLNCYEEMEEFKKLVMG
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
What are the official names of this protein?
MICOS complex subunit MIC19, Altered inheritance of mitochondria protein 13, mitochondrial, Mitochondrial contact site complex 19 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic19 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Note=Enriched at crista junctions.
Protein: VTDB_BOVIN
Sequence: MKRILVFLLAVAFVHALERGRDYEKDKVCKDLASLGREDFTSLSMVLYSRKFPSGTFEQISHLVNEVVSLTVTCCAEGADPDCYDNRTSALSDKSCESNSPFPVHPGTPECCTHEGLEKKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKDFADRFMYEYSINYGQAPLTLLVGYTKSYLSMVGSCCTSPNPTVCFLKERLQLKHFSLLTIMTNRICSQYAAYGKEKSRLSHLIKFAQKVPTAHLEDVLPLAEDITTILSKCCDSVSEDCIKELPEYAVKLCDNLSTKNSKFKDCCQEKTPMEIFVCAYFMPASPNPELPDVKLPMNKDVCDEGNTKVLDQYIFELSRKTQIPEVFLTKILESTLKSLDECCHSESSTACLNAKGPQLTRELSSFIQKGQELCADYSENTFTEYKKKLAERLRGKFPDATETDLQELVAKRSDFASKCCSVNSPPLYCNSEIDAEINTLQS
What is the function of this protein?
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
What are the official names of this protein?
Vitamin D-binding protein, DBP, VDB, Gc-globulin, Group-specific component.
What is the protein family that this protein belongs to?
Belongs to the ALB/AFP/VDB family.
What are the subcellular locations of this protein?
Secreted.
Protein: UNG_MYCTO
Sequence: MTARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYLPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFSVAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRGVLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAPLVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFGSRPFSRANELLVGMGAEPIDWRLP
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEPR1_XENLA
Sequence: MNSLEQAEDLKAFERRLTEYVSCLQPTTGRWRMLLIVVSVCTATGAWNWLIDPETQKVSFFTSLWNHPFFTISCITLIGLFFAGIHKRVVAPSIIAARCRTVLAEYNMSCDDTGKLILKPRPHVQ
What is the function of this protein?
May form with the serine/threonine protein phosphatase ctdnep1 an active complex dephosphorylating and activating lipins.  Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels.  May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics.  May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity).
What are the official names of this protein?
Nuclear envelope phosphatase-regulatory subunit 1, Transmembrane protein 188.
What is the protein family that this protein belongs to?
Belongs to the CNEP1R1 family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Cytoplasm.
Protein: RUTA_ECOCB
Sequence: MQDAAPRLTFTLRDEERLMMKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSAQYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVASVPGAEGVLLTFDDFLSGIETFGERIQPLMQCRAHLPVLTQEVA
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: RS19_ALIF1
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPVKTWSRRSMIIPTMINLTIAVHNGRQHVPVFVTEDMIGHKLGEFAPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: ULAD_SHIBS
Sequence: MSLPMLQVALDNQTMDSAYETTRLIAEEVDIIEVGTILCVGEGVRAVRDLKALYPHKIVLADAKIADAGKILSRMCFEANADWVTVICCADINTAKGALDVAKEFNGDVQIELTGYWTWEQAQQWRDAGIQQVVYHRSRDAQAAGVAWGEADITAIKRLSDMGFKVTVTGGLALEDLPLFKGIPIHVFIAGRSIRDAASPVEAARQFKRSIAELWG
What is the function of this protein?
Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
3-keto-L-gulonate-6-phosphate decarboxylase UlaD, 3-dehydro-L-gulonate-6-phosphate decarboxylase, KGPDC, L-ascorbate utilization protein D.
What is the protein family that this protein belongs to?
Belongs to the HPS/KGPDC family. KGPDC subfamily.
Protein: KDUI_ECOUT
Sequence: MDVRQSIHSAHAKTLDTQGLRNEFLVEKVFVADEYTMVYSHIDRIIVGGIMPVTKTVSVGGEVGKQLGVSYFLERRELGVINIGGAGTITVDGQCYEIGHRDALYVGKGAKEVVFASIDTATPAKFYYNCAPAHTTYPTKKVTPDEVSPVTLGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYFYFNMDDDACVFHMMGQPQETRHIVMHNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVKDLR
What is the function of this protein?
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
What are the official names of this protein?
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase, DKI isomerase.
What is the protein family that this protein belongs to?
Belongs to the KduI family.
Protein: TM121_HUMAN
Sequence: MVLPPPDRRHVCLTTLVIMGSMAVMDAYLVEQNQGPRKIGVCIIVLVGDVCFLLVLRYVAVWVGAEVRTAKRGYAMILWFLYIFVLEIKLYFIFQNYKAARRGAADPVARKALTLLLSVCVPGLFLLLVALDRMEYVRTFRKREDLRGRLFWVALDLLDLLDMQASLWEPPRSGLPLWAEGLTFFYCYMLLLVLPCVALSEVSMQGEHIAPQKMMLYPVLSLATVNVVAVLARAANMALFRDSRVSAIFVGKNVVALATKACTFLEYRRQVRDFPPPALSLELQPPPPQRNSVPPPPPPLHGPPGRPHMSSPTRDPLDT
What is the function of this protein?
May play a role in MAPK signaling.
What are the official names of this protein?
Transmembrane protein 121.
What is the protein family that this protein belongs to?
Belongs to the TMEM121 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Note=May localize to the plasma membrane.
Protein: UDB18_MACFA
Sequence: MSVKWTSVILLIQLSFYFSSGSCGKVLVWAAEYSHWMNMKTILEELVQRGHEVTVLASSASILFDPNNSSALKIEVFPTSLTKTEFENIIRQQIKRWSELPKDTFWLYFSQMQEIMWKFGDITRNFCKDVVSNKKLMKKLQKSRFDVVFADAIFPCSELLAELLNTPLVYSLRFTPGYNFEKHCGGFLFPPSYVPVVMSELSDHMTFMERVKNMIYMLYFDFCFQIYAMKKWDQFYSEVLGRPTTLSETMGKADIWLIRNSWNFQFPHPLLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVTNMKEERANVIASALAQIPQKVLWRFDGKKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGSNGIYEAIYHGVPMVGIPLFADQPDNIAHMKAKGAAVRLDFDTMSSTDLVNALKTVINDPLYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRPAAHDLTWFQYHSLDVIGFLLACVATVIFIIMKCCLFCFWKFARKGKKGKSD
What is the function of this protein?
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.  This isozyme displays activity toward 3-hydroxyandrogens.  It is principally active on C19 steroids having a hydroxyl group at position 3-alpha of the steroid molecule and also active on planar phenols and bile acids.
What are the official names of this protein?
UDP-glucuronosyltransferase 2B18, UDPGT 2B18.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: APOC4_ATEGE
Sequence: MSLLRHSLQALPALCLCVLVLACIGACQSEAHEGTPSPPPEQKTRRWNLVQSRMKELLEPAVTRTRDRWQWLWNLSILRGFIQTYYDDHLRDLGPRTKTWLLESKDTLLNKTYSLCPRLLCTDKN
What is the function of this protein?
May participate in lipoprotein metabolism.
What are the official names of this protein?
Apolipoprotein C-IV, Apo-CIV, ApoC-IV, Apolipoprotein C4.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C4 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRMA_HELPY
Sequence: MLKPMYYEFFFIFPKERELFESFLLDATHLALEESSLENLKAFDDKETIGFISQSNWHYFATHDPLKKDLKENLKEKPPHLKNFVILRSQKDLNNSLIPALEAFCLNLKQNLQSEFDFFYLSRNLASKDWLEAYKQAILPVQCTKFYIHPSWHQKPSHVVTNDCIMIDPALAFGSGHHESTSMCLELLSDIDLKRKNALDVGCGSGILSIALKKQGVSALVACDTDSLAVEETLKNFSLNQIPLLVQDKVIYGSTQKIEGRFDVIVANLVADVIKSLYSEFVRLCNHTLILSGILETHLNSVLQIYYNGFEVLEQRQRNEWVALKLLKKQPIN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NS1_I82A2
Sequence: CFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIKTATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRDW
What is the function of this protein?
Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated RIGI ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors like IRF3 and IRF7.  Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR.  This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm.  Also binds poly(A) and U6 snRNA.  Suppresses the RNA silencing-based antiviral response in Drosophila cells (By similarity).
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm (By similarity).
Protein: LCL3_VANPO
Sequence: MSDIDEKNDTKESSFSSDVVLLSLLISGSTLGAIAGYNRYLKQVTKATDIPNYMFRKRWMYGKVTAVGDGDNFHLFHTPGGIFGGWGWLRKVPKLPKSDSNGLIVSRKKTSNFYSGLKNSYHKFTGSYRYSSEYFLDLKVPYKNLRNLPTVPIRLCAIDAPERAHFGNTSQPYGDEALIWLRNRLLGKYVWVKPLSVDQYNRCVSKVVCWNWLGWQNISLQMVRQGLAVVYEGKTSAEFDREEFLYRFYERRSKAKKRGLWRQRVIETPGEYKKKIKK
What are the official names of this protein?
Probable endonuclease LCL3.
What is the protein family that this protein belongs to?
Belongs to the LCL3 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single- pass membrane protein.
Protein: THLA_CLOPA
Sequence: MKEVVIASAVXTAXG
What is the function of this protein?
Catalyzes the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA.
What are the official names of this protein?
Acetyl-CoA acetyltransferase, Acetoacetyl-CoA thiolase, CP 13.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C356_FUNHE
Sequence: MGYFYLTAETWTLLVAFVTLLLIYAYWPYGTFKRLGISGPKPVPFFGTMLHYRRGFFTFDEECKKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFTNRRNFHLNGPLYDALSVAEDDQWKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMKKKADKDEPLDLKEFFGSYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPLFLAVAFFPFLGPILEKFELSFFPKSVTDFFYASLEKIKSNREASQQKSRVDFLQLMIDSQKNSGAQQDKSLTDHEILSQSMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEIDATFPNKAPVHYQPLMEMEYLDCVINESLRLFPIAARLERVAKAAVEINGIVIPKDMVVMIPTWPLHRDPEIWPEPEAFKPERFSKKNKDNIDPYIYMPFGSGPRNCIGMRFALVLIKLAVVEILQQYSFSVCKETEVPFEMDIQGLLAPKRPIQLKLVPRS
What is the function of this protein?
Putative steroid 6-beta-hydroxylase.
What are the official names of this protein?
Cytochrome P450 3A56, CYPIIIA56.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: CLIP3_PONAB
Sequence: MTKTDPAPMAPPPRGEEEEEEEEDEPVPEAPSPTQERRQKPVVHPSAPAPLPKDYAFTFFDPNDPACQEILFDPQTTIPELFAIVRQWVPQVQHKIDVIGNEILRRGCHVNDRDGLTDMTLLHYACKAGAHGVGDPAAAVRLSQQLLALGADVTLRSRWTNMNALHYAAYFDVPDLVRVLLKGARPRVVNSTCSDFNHGSALHIAASSLCLGAAKCLLEHGANPALRNRKGQVPAEVVPDPMDMSLDKAEAALVAKELRTLLEEAVPLSCALPKVTLPNYDNVPGNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPSLGSLQQRDRAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSVGAKKVHQVTMTQPKRTFTTVRTPKDIASENSISRLLFCCWFPWMLRAEMQS
What is the function of this protein?
Functions as a cytoplasmic linker protein.  Involved in TGN-endosome dynamics.  May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity).
What are the official names of this protein?
CAP-Gly domain-containing linker protein 3, Cytoplasmic linker protein 170-related 59 kDa protein, CLIP-170-related 59 kDa protein, CLIPR-59.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cytoplasm. Golgi apparatus, Golgi stack. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.