PharMolix/UniProtQA huggingface dataset:
Protein: CYB_TOXPR
Sequence: MPNHHTLLSSSLFPVGSNISTWWNFGSMLLTCTALQISTGFFLAVHYTANINLAFSSIIHITRDVPYGWIMQNLHAIGASLFFLCIYIHIARGLYYGLYMNKGVWLSGTTLLIILMATAFFGYVLPWGQMSFWAATVITNLLTAVPYLGNSLTTWLWGGFSINDPTLTRFFALHFILPFLITSLSSIHIILLHNEGSNNPLGTNSDIDKVPIHPYHSYKDMFMISSMITLLFIVLSFMPDLLNDPENFSKANPMTTPQHIKPEWYFLFAYSILRSIPNKLGGTLALLMSVIILTTTPFTHTSYIRPMTFRPLTQALFWTLIATFITITWTATKQVEPPFTLISQVASVTYFSFFIINPIFGWAENKTMMNN
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NIKR_METM6
Sequence: MVDMDRISISLPTNLLAEFDEIIEERGYASRSEAIRDSIRDYLIKHKWIHSLEGDRAGTISIIYDHHSTDVMEKLTNIQHDYEKLIVATIHMHLDHDHCMEVVLVKGDASDIKELTDKLTSQKGVKQVKLTVMVPGGNIPQ
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: NDHI_NANDO
Sequence: MFPMVTGFMNYGQQTVRAARYIGQSFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSVIGDYTIRTILNSTPIKKTAGNPLDSKTITNF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: IER5L_XENLA
Sequence: MEGALDAQSLISLSLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQLYLSERYAELYRRQPFPQTMDECDEPDIPELSPLQIPEEGEDEMHQLPRIHSGGAELLEPLSSEETLELPPCAHSPHPAKEPQSHAAFYSPVPSRGFCSSGESAGPPQCSHTTVLDLDTHVVTTVESGYLHQDCPCQGAPLLSKRKYAPAGYGSYSGHGGPGEDLGDTAEPSFVPCKRGRYEDFCPQPLGEPADSNNNNISNLISIFGSGFSGLMSRQTEAEQTLNGHLCGKHALGSLGAWTRAIVAF
What are the official names of this protein?
Immediate early response gene 5-like protein.
What is the protein family that this protein belongs to?
Belongs to the IER family.
Protein: LPXD_PARD8
Sequence: MEFSAQQIAGFLNGTIEGDPNVKVSNFSKIEEGKPGTLTFLANLKYAHHIYNTEASIVLVNNDFKPEQPIRATLVKVENAYAALAMLLNLVEQSKSKKKGVDSTAFIAASATVSDDCYVGNFAYIGEGVKMGKNCMVYPHAYIGDHVTVGDNCVFYPHATVYENCIIGNNCILHAGSVVGADGFGFAPEGETYKKIPQLGNVIIEDDVEIGANTTIDRAVMDSTIIHRGVKLDNLVQIAHNVEVGENTVMAAQVGIAGSVKVGKHCMFGGQVGLAGHIHVADHVVFGAQAGVISDVKEATTLLGAPAINAKNFMRSSAIFNRLPDIYRSLGQMQREIEQLKKEINKQ
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: LIPA_OLEA2
Sequence: MSAQENSAPFLRIPPWLRTRIPCNRTYTATRELIGDLNLHTVCQSAKCPNMFECFSSRTATFLILGGTCTRNCAFCNIEPGDVLPPDAGEPQRVALAAARLELKHVVITSVTRDDLPDGGAAHFAATIQAVRSRLPRCTVEVLIPDFQGDAAALQTVLQARPDVLNHNVETPPAHYSRIRPQADYSQSLELLRRARAAGFTVKSGLMTGLGETDAEVLGVIDDLCATGCNIVTVGQYMRPSRRHPAVQRYVHPDMFEEYAAYGRARGIPHMFCAPLVRSSYNASMFVQEKN
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFGM_DROYA
Sequence: MSLITRLLTGNITLRRRAMESLGKAGYSSHAKFSEHKPIERIRNIGISAHIDSGKTTLTERILFYTGRIAEMHEVRGKDNVGATMDSMELERQRGITIQSAATYTLWKDTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCAVGGVQSQTLTVNRQMKRYNVPCLAFINKLDRLGSNPYRVLSQMRSKMNHNAAFIQLPIGVESNCKGIVDLVREKAIYFEGEHGMDIRLDEIPQDMRVESLERRQELIEHLSNADETLGELFLEEKPFTEDDIKAALRRTCINRTFTPVLVGTALKNKGVQPLLDAVLDYLPNPGEVENLGFIEKEGQDPEKVVLNPARDGKDPFVGLAFKLEAGRFGQLTYLRCYQGVLRKGDNIFNARTNKKVRIARLVRLHSNQMEDVNEVYAGDIFALFGVDCASGDTFTTNPKNNLSMESIFVPEPVVSMAIKPNNTKDRDNFSKAIARFTKEDPTFHFFFDNDVKETLVSGMGELHLEIYAQRMEREYGCPVTLGKPKVAFRETLVGPCEFDYLHKKQSGGSGQYARIIGVMEPLPPTQNTLLEFVDETVGTNVPKQFVPGVEKGYREMAEKGMLSGHKLSGIRFRLQDGGHHIVDSSELAFMLASHGAIKEVFQNGSWQILEPIMLVEVTAPEEFQGAVMGHLSKRHGIITGTEGTEGWFTVYAEVPLNDMFGYAGELRSSTQGKGEFTMEYSRYSPCLPDVQDQIVRQYQESQGLAQPDKKKKKN
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.  Essential during development as it acts as a retrograde signal from mitochondria to the nucleus to slow down cell proliferation if mitochondrial energy output is low (By similarity).
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TEANC_MACFA
Sequence: MSDKNQIAARASLIEQLLSKRNFEDLGNHLTELETIYVTKEHLQETDVVRAVYRVLKNCPSVALKNKAKCLLSKWKAVYKETHSKARNSPKLFPVRGNEENSGPSHDPSQDETLGICSSNSLSSQDVAKLSEMIVPENRAIQLKPKKEHFGDGGPESTGKRLSELLDPITPMRTKCIELLYAALTSSSADQPKADLWQNFAREIEEHVFTLYSKNIKKYKTCIRSKVANLKNPKNSHLQQNLLSGTMSPREFAEMTVMEMANKELKQLRASYTESCIQEHYLPQVIDGTQTNKIKCRRCEKYNCKVTVIDRGTLFLPSWVRNSNPDEQMMTYVICNECGEQWYHSKWVCF
What are the official names of this protein?
Transcription elongation factor A N-terminal and central domain-containing protein, TFIIS central domain-containing protein 1.
Protein: OR2K2_HUMAN
Sequence: MQGENFTIWSIFFLEGFSQYPGLEVVLFVFSLVMYLTTLLGNSTLILITILDSRLKTPMYLFLGNLSFMDICYTSASVPTLLVNLLSSQKTIIFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYSIIMNRCVCARMATVSWVTGCLTALLETSFALQIPLCGNLIDHFTCEILAVLKLACTSSLLMNTIMLVVSILLLPIPMLLVCISYIFILSTILRITSAEGRNKAFSTCGAHLTVVILYYGAALSMYLKPSSSNAQKIDKIISLLYGVLTPMLNPIIYSLRNKEVKDAMKKLLGKITLHQTHEHL
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2K2, HTPCRH06, Olfactory receptor OR9-17.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TIG_LEGPL
Sequence: MQVSVETLEGLERKVTVSVPTEKVEEEVSSRLRNLARKVKIDGFRPGKVPFNVVKSRFSDSVREEVAREMVQSTLYEALQKNELVPAGYPHVEPLEIEPGKDFKYTAVFEVMPVFEVVELNQAPVELIQSEVSDKDVDNMIEKLREQNKEWHEVTHAVKKGDKVVIDFQGFLDDKPFQGGSAEGYELVIGSGSMIPGFEDGIIGGKIDKPLDIKVSFPEDYGHKDLAGKEATFKITIKKIMEGKLPALDEAFAEKFNIKEGGIESLKKDIRENMARELERRVNMMNREKLFDSLMSVNHVELPIALIDKEIEHLKHDMYHRLFGHEHKDDEKIPDFPRELFEEQAKRRVHLGLLFAEYVKKHEIVADNDKVNAMIDKFASAYESPDELRAWYQSSKEHMAEVEALVMEDMVADKIAEDAKLKYKNMDYDSVMNPKKGTEKKGE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: ODBA_DICDI
Sequence: MISQSYRILSRISRNNELKKTFLTNLNCKSSSPSIIRSFCKKQNLDENFEYTNKLEVQELKHYIPCYTIMDQEGVVSKPDQDPNFSKEEVIKMYTTMLTLNVMDSILYDVQRQGRISFYMTSFGEEAIHIGSAAALEMSDTIFAQYRETGVFMWRGFTINDIINQCCTNEHDLGKGRQMPMHFGSRKINLQTISSPLTTQLPQAVGSSYAQKLAGEKNCTIVYFGEGAASEGDFHAAMNFAAALSTPTIFFCRNNKWAISTPSKEQYKGDGIAGRGPNGYGMKTIRVDGNDIWAVYNVTKLARKIAVEEQVPVLIEAMTYRVGHHSTSDDSSRYRTVEEINAWKEGKNPISRLRNYMNHKGWWSDAQEKETIANARTTVRESLVNAEKQYKPSINEIFTDVYDKPTPNLIEQQKELIEHLKLYPDEYPLNQFADSKLILKD
What is the function of this protein?
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain, BCKDE1A, BCKDH E1-alpha.
What is the protein family that this protein belongs to?
Belongs to the BCKDHA family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GUB_BACSU
Sequence: MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSGFWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGLYEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEKIVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVDEWLGSYNGVNPLYAHYDWVRYTKK
What are the official names of this protein?
Beta-glucanase, 1,3-1,4-beta-D-glucan 4-glucanohydrolase, Endo-beta-1,3-1,4 glucanase, Lichenase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 16 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GLNE_AROAE
Sequence: MLEADAARLKTDRLGYNPLHVLRADAATRRQEPAILTMIRSSPPMSVDSSPLPEALRHAASISRFMRRMLDSRPWLAAQLAGSLGQPLDSEAMSSFLANRGVDEARLRASLRHLRSWVVCHVLTRDLNGFADLAEVTETMTVLAEVTVRATYEVLREGLVARYGAPLSPTGWEQELLVIGMGKLGGRELNVSSDIDLIFVYPEDGDTGGNKVISNFEFFERLGKQMIQALADVTEHGQVFRVDMRLRPNGDSGPLVCSFDMLENYFITQGREWERYAWIKARVLAGERYHELEQIARPFVFRKYLDFGSINAMRALHAQIRREVTRRDRVNNIKLGPGGIREIEFTAQVFQLIRGGREPGLQVRATLDVLAVLGERGILTPQTVGELAEAYDFLRRLEHRLQYLDDAQTHDLPGNDEDCECIARAMDFPDYTSFLGVLDHHRAAVSRHFDHVFGDPSEEAHTLDSMWAAARDVEQAEPILSRLGYGDPSGAAHRLAALHGSARYQQLPNHIRSRLDALMPRVVEVAAATPGPDETLARCIDLIEAISRRGAYLALLQQYPQALRRVADLVGASRWAAQYLTRHPILLDELLDDRNLEPAPDWDALRAQMRDTLDTLEPDMERQMDVMREQHHAQVFRLLTQDIAGLLTVEKLADHLSALADLMLELALPLVWRKIKIRHRDDPAFAVIAYGKLGGKELGYASDLDIVFLFDDPAPEALEVYTRLAQRINTWLSSQTAAGILFETDLRLRPNGESGLLVTSIESFRKYQLESAWVWEHQALTRARFAAGDATIGAAFERIRCEVLRLPRDIAALRAEVLAMRRKMSDAHAGKSERFNLKHDAGGLVDVEFLIQYLVLGHAHRYPELTGNLGNIALLRIAGELGLIPAELAARCGDSYRLFRRLQHRQRLNGLLSLVAPDEVAAAREPVRALWTIVFGSA
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: RS30_CANAL
Sequence: MGKVHGSLARAGKVKSQTPKVEKQEKPKKPQGRAYMRLLYTRRFVNVTLTNGKRKMNPSPASQ
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
40S ribosomal protein S30.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS30 family.
Protein: UBIE_SHESM
Sequence: MSEGESKNTHFGYKTVEADKKADLVAGVFHSVAAKYDIMNDVMSFGIHRFWKRYTIEVSGARPGMKVLDLAGGTGDLTAKFSHLVGEKGEVVLADINDSMLKVGRTKLRDRGIVGNVSYVQANAEALPFPDNHFDIITIAFGLRNVTDKDAALRSMNRVLKPGGKLLVLEFSKPQHELMRKVYDLYSFKVLPKMGEIITKDADSYEYLAESIRMHPDQETLKQMMVDAGFEQVDYTNMTDGIVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: Y1350_SULIK
Sequence: MSMPYDNEAKIKQAVILLQKIVNDTSVPRNIRRAATDAIRNLQDLGLSPAVRAANAIGILEDISQDPNMPTHARISIWNVVSILETVKD
What are the official names of this protein?
UPF0147 protein M164_1350.
What is the protein family that this protein belongs to?
Belongs to the UPF0147 family.
Protein: ZFS1_SCHPO
Sequence: MVYSPMSRPQVPLAFRQWPPYNYKSDPLVNSKLSQSTTSVNAGPSLISPSFLDSYANSSSLLHKPSTNLGSLKTSSLLASDEVFPSSVMPQLRPLDSSLSVSPEMDGWPWHHNSSSNPQGYAWTPSLLSSNATSYLHSGSSPHGNTSNHPSPISSLESLPSRSSTGSGSLDFSGLANLHDDSKSLAMSLNMAGVPVSVDENSQTSFPFVHGQPESTMSRKPKLCVQSKSMTNIRNSVAKPSLVRQSHSAGVIPIKPTASNASIRNAPSNLSKQFSPSGNSPLTEASKPFVPQPSAAGDFRQAKGSASHPHGSGSSNGVAPNGKRALYKTEPCKNWQISGTCRYGSKCQFAHGNQELKEPPRHPKYKSERCRSFMMYGYCPYGLRCCFLHDESNAQKSATIKQSP
What is the function of this protein?
Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation.  Binds to ARE present in the arz1 mRNA and stimulates the rate of arz1 mRNA decay.  Required for coordination of septum formation with exit from mitosis.  Involved in the mating response pathway.  Induces sexual development and ascus formation.
What are the official names of this protein?
Zinc finger protein zfs1, Multicopy suppressor of overexpressed cyr1 protein 4.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ARNB_SALG2
Sequence: MSDFLPFSRPAMGAEELAAVKTVLDSGWITTGPKNQELEAAFCRLTGNQYAVAVSSATAGMHIALMALGIGEGDEVITPSMTWVSTLNMIVLLGATPVMVDVDRDTLMVTPEHIEAAITPQTKAIIPVHYAGAPADLDAIYALGERYGIPVIEDAAHATGTSYKGRHIGARGTAIFSFHAIKNITCAEGGIVVTDNPQFADKLRSLKFHGLGVDAWDRQSGGRAPQAEVLAPGYKYNLPDLNAAIALAQLQKLDALNARRAAIAAQYHQAMADLPFQPLSLPSWEHIHAWHLFIIRVDEARCSITRDALMASLKTKGIGTGLHFRAAHTQKYYRERFPTLTLPDTEWNSERICSLPLFPDMTESDFDRVITALHQIAGQ
What is the function of this protein?
Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase, UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase, UDP-Ara4O aminotransferase, UDP-4-amino-4-deoxy-L-arabinose aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
Protein: RL31_FRACC
Sequence: MKPDVHPTYHETTVTCTCGNTFTTRSTKENGVVNAEVCSQCHPFYTGKQKILDVGGRVEKFERRFGRRRPGEKVGGAK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: FOLD_FLAJ1
Sequence: MQLLDGKKTSNDIKNEIAAEVQSIKAAGGKVPHLAAVLVGNNGASLTYVGSKVKSCQEIGFDSTLVSLPETITEDELLAKIKELNEDDNLDGYIVQLPLPKHIDEQKILLAIDPDKDVDGFHPTNFGRMALEMESFIPATPFGIMELLERYKVETAGKHTVVIGRSHIVGRPMSILMSRKGNPGDSTVTLTHSRTKDLAEFTKNADIIITALGVPEFLKADMVKEGVTVIDVGITRVEDASNAKGYVIKGDVDFEGVSKKASFITPVPGGVGPMTIAMLLKNTLLARKMRSAKNK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: ATPE_FRATN
Sequence: MTKKYLKVDVVSPLGSVFKGEADMVSLRGSAGEMGIAYGHTELLSTLPAGVVNVRKDQHTDVLYVSGGIVEVTPTRVTIMVDDMERAENLNQAEAEKARARAKEVLKNPDASKLDIEAANKRLKEADARLKALNSSNGLYYSKDD
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ERIB_HERER
Sequence: MGNALAVYRDTFPPSPTYSVNDVPDLTGKIIIVTGGNTGLGKETIKVLLQHNATVYLAARSPSKAKAAIDELRDMTGKEALFLQLDLSDLKSIKESARQFLEKEKKLDVLLNNAGVMMSPIEQLTKDGYDLQFGTNVLGHFYFTKLLLPLLLSTAKTTGEARVVTLSSGAGLMVDEIDFNTLKDSPARKKLGTTKLYMQSKLGNMVFSLELARRYADQGIISTSINPGTLKSDLARYVDSLIYKLILKIISYPVPMGTLSPLYAATYPDGKSLNGKYLKPWAREGELSKTATDPELGKELWTWMEEQVAPFESNAS
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of erinacines, cyathane-xylosides that show unique biological activities, including leishmanicidal activity, stimulating activity for nerve growth-factor synthesis, and agonistic activity toward the kappa opioid receptor (PubMed:31535864).  The geranylgeranyl diphosphate (GGPP) synthase eriE catalyzes the first step in erinacines biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:31535864).  GGPP is then substrate of the diterpene cyclase eriG for the production of cyatha-3,12-diene (PubMed:28371074).  EriG is unable to use geranyl diphosphate (GPP) or farnesyl diphosphate (FPP) as substrates (PubMed:28371074).  The cytochrome P450 monooxygenase eriI then hydroxylates cyatha-3,12-diene at C-14 of the seven-membered ring to produce erinacol, which is further hydroxylated at C-15 by the cytochrome P450 monooxygenase eriC to yield cyathadiol (PubMed:31535864).  The cytochrome P450 monooxygenase eriA then catalyzes C-11 hydroxylation in the presence of the short chain dehydrogenase/reductase (SDR) eriH, which leads to the production of cyathatriol (PubMed:31535864).  The acetyltransferase eriL converts cyathatriol into 11-O-acetyl-cyathatriol (PubMed:31535864).  The SDR eriH catalyzes further oxidation of 11-O-acetyl-cyathatriol into 1-O-acetylcyathin A3 (PubMed:31535864).  Finally, the glycosyl transferase eriJ tranfers xylose from UDP-xylose onto C-14 of 11-O-acetyl-cyathatriol to form eracine Q (PubMed:31535864).  EriJ is also able to convert 11-O-acetyl-cyathatriol to eracine Q2 by using UDP-D-glucose as cosubstrate, but at a lower rate (PubMed:31535864).  In the absence of eriL and eriJ, the SDR eriH is able to convert cyathatriol to cyathin A3; this is likely a switching mechanism in the biosynthesis of cyathins (C-14 ketogroup)and erinacines (C-14 glycosylated group) (PubMed:31535864).  The roles of the SDR eriB, the polyprenyl transferase eriF and the dehydrogenase eriK have still to be identified (Probable).
What are the official names of this protein?
Short-chain dehydrogenase/reductase eriB, Erinacine biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RS12_TROW8
Sequence: MPTIQQLVRKGRRPKVNKTKSPALRGNPQQRGVCSRVYTTTPKKPNSALRKVARVKLSNGTEVTVYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYKVVRGALDAQAVKDRKQARSRYGAKMEKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: HUS1_HUMAN
Sequence: MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
What is the function of this protein?
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.  The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.  Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER).  The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates.  The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
What are the official names of this protein?
Checkpoint protein HUS1, hHUS1.
What is the protein family that this protein belongs to?
Belongs to the HUS1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Note=In discrete nuclear foci upon DNA damage. According to PubMed:11077446, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.