PharMolix/UniProtQA huggingface dataset:
Protein: QUEC_BACC7
Sequence: MKKEKAVVVFSGGQDSTTCLFWAMEQFAEVEAVTFNYNQRHKLEIDCAAEIAKELGIKHTVLDMSLLNQLAPNALTRTDMEITHEEGELPSTFVDGRNLLFLSFAAVLAKQVGARHIVTGVCETDFSGYPDCRDVFVKSLNVTLNLSMDYPFVIHTPLMWIDKAETWKLSDELGAFEFVREKTLTCYNGIIGDGCGECPACQLRKAGLDTYLQEREGASN
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: DNLI_VACCA
Sequence: MTSLREFRKLCCDIYHASGYKEKSKLIRDFITDRDDKYLIIKLLLPGLDDRIYNMNDKQIIKLYSIIFKQSQEDMLQDLGYGYIGDTIRTFFKENTEIRPRDKSILTLEEVDSFLTTLSSVTKESHQIKLLTDIASVCTCNDLKCVVMLIDKDLKIKAGPRYVLNAISPHAYDVFRKSNNLKEIIENASKQNLDSISISVMTPINPMLAESCDSVNKAFKKFPSGMFAEVKYDGERVQVHKNNNEFAFFSRNMKPVLSHKVDYLKEYIPKAFKKATSIVLDSEIVLVDEHNVPLPFGSLGIHKKKEYKNSNMCLFVFDCLYFDGFDMTDIPLYERRSFLKDVMVEIPNRIVFSELTNISNESQLTDVLDDALTRKLEGLVLKDINGVYEPGKRRWLKIKRDYLNEGSMADSADLVVLGAYYGKGAKGGIMAVFLMGCYDDESGKWKTVTKCSGHDDNTLRELQDQLKMIKINKDPKKIPEWLVVNKIYIPDFVVEDPKQSQIWEISGAEFTSSKSHTANGISIRFPRFTRIREDKTWKESTHLNDLVNLTKS
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.  Recruits cellular topoisomerase II to sites of viral replication and assembly.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: ACT_OGAPD
Sequence: MDGEDVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQILFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSERGYTFSTTAEREIVRDIKEKLCYVALDFDQELQTSSQSSAIEKSYELPDGQVITIGNERFRAPEVLFHPGPLGLEAAGIDQTTYNSIIKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHHKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PURA1_PSET1
Sequence: MGKNVVVLGTQWGDEGKGKVVDLLTDKASLVVRYQGGHNAGHTLVIDGEKTVLHLIPSGVLRDNVKCVIGNGVVLSPEALMREIGMLEARGVPVRERLLISAACPLILPFHVALDVARETARGDKPIGTTGRGIGPAYEDKVARRGLRVGDLFNPELFAAKLEEVLEYHNFTLVNYYKVDAVDFQKTFDDAMAVADILKAMIVDVTELLDQTRLAGDNILFEGAQGTLLDIDHGTYPYVTSSNTTAGGVATGAGFGPLHLDYVLGIIKAYTTRVGSGPFPTELYDGLDKQDPVGKHLGDKGHEFGATTGRLRRTGWLDAVAMRRAVQINSISGFCLTKLDVLDGLETLKICTGYKLEDGTVTNVTPLAAEGYEKVTPIYEEMPGWSENTVGVTSLDGLPKAAIDYVKRIEELTGVPVDIISTGPDRVETMILRNPFA
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase 1, AMPSase 1, AdSS 1, IMP--aspartate ligase 1.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_STRPC
Sequence: MAEITSAKAMARTVRVSPRKTRLVLDLIRGKKVADAIAILKFTPNKAARVIEKTLNSAIANAENNFGLEKANLVVSETFANEGPTMKRFRPRAKGSASPINKRTTHVTVVVSEK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: DNAA_AQUAE
Sequence: MELNALIKKIESVDSYAREFLKKFEIKQEKGKFLFIAPGEDYREWLETIVNTFLEEEVRKLIEVKEKEEKKKVEIKDFLNPKYTLENFIVGEGNRLAYEVVKEALENLGSLYNPIFIYGSVGTGKTHLLQAAGNEAKKRGYRVIYSSADDFAQAMVEHLKKGTINEFRNMYKSVDLLLLDDVQFLSGKERTQIEFFHIFNTLYLLEKQIILASDRHPQKLDGVSDRLVSRFEGGILVEIELDNKTRFKIIKEKLKEFNLELRKEVIDYLLENTKNVREIEGKIKLIKLKGFEGLERKERKERDKLMQIVEFVANYYAVKVEDILSDKRNKRTSEARKIAMYLCRKVCSASLIEIARAFKRKDHTTVIHAIRSVEEEKKKDRKFKHLVGFLEKQAFDKIC
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids (By similarity).
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ST1B1_CANLF
Sequence: MISPKDFLRKNLKMIHGYPIIYTFANNWENIEQFHSRPDDIIIATYPKSGTTWVSEIVDMVLNNGDVEKCKRDFITVKVPMLEMAVPGLRTSGIEQLEKNPSPRLVKTHLPIALLPKSFWENNCKMIYLARNAKDVAVSYYHFDLMNNLEPAPGPWEEYLERFMTGNVAYGSWFNHVKSWWKKKEEHPILFLYYEDMKENPKREVQKIARFLEKNLNDEVLDKIIHHTSFEMMKDNPLVNYTHLPSTVMDHSKSSFMRKGIAGDWKNYFTVAQNEKFDVIYKKEMSGTTLQFRTEI
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:11368519).  May play a role in gut microbiota-host metabolic interaction.  O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria.  The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (By similarity).
What are the official names of this protein?
Sulfotransferase 1B1, ST1B1, cSULT1B1, Sulfotransferase family cytosolic 1B member 1.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTFA_ENT38
Sequence: MIKWPWKSNETAPDALLPWDEALAIPVLASLSADEQSRLVQLADRFLQQKRLVPLQGFELDELKSARIALLFCLPVLELGIEWLDGFHEVLIYPAPFVVDDEWEDDIGLVHNQRVVQSGQSWQQGPIILNWLDIQDSFDASGFNLIVHEVAHKLDTRNGDRASGVPFIPLREVAGWEHDLHAAMNNIQDEIDLVGESAASIDAYAATDPAECFAVLSEYFFSAPELFAPRFPALWQRFCHFYQQDPMQRLRENAGYDGNASPQVH
What is the function of this protein?
Involved in the regulation of ptsG expression by binding and inactivating Mlc.
What are the official names of this protein?
Protein MtfA, Mlc titration factor A.
What is the protein family that this protein belongs to?
Belongs to the MtfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS_LACGA
Sequence: MNLKSDIEIAQNTKELPIKEIAQKIDLRPEEIELYGNDKAKISWKGINCIKKNQKLGKLILVTSISPTPAGEGKSTITIGLGDAIRNQLHKNTLIALREPSMGPVFGLKGGATGGGYAQIIPMEDINLHFTGDMHALTSAIDTLAALVDNYIYQDNSLELDPNRILLKRGIDVNDRTLRKITIGQGSRFNGIEHEASFAITVANELMAILCLATDINDLKKRIGNILVGFSVKDEPVYVKDLGFEGAIAALLSTALKPNLVQTLEHTPAIVHGGPFANIAHGANSVIATNTALHLSDYVLTEAGFGADLGGQKFMDFVSNHLDKRPDAVVVVATVRALKYQAEESTDHLDEENIPALEKGFANLKRHMENMAHYGVPVIVLINKFASDTDQELNKLKELVQDDGFECEIVSYHDEGSKGGIQAAEKVVELTGKASDFKPVYKPEDSVEDKIAKIAHKIYHAKDIEYSDTAKKQLAEIKKMGKDELPVIIAKTQYSFTDKKKILGAPEDFILHVKDLALKNGAGFIVVATGSILDMPGLPKHPAALDIDVDNNGKISGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: RECO_NOCFA
Sequence: MRLYRDEAVVVRQHKLGEADRIVTLLTRQHGLVRAVAKGVRRTRSRFGARLEPFSYIDVQLHPGRNLDTVTQVHTVESFAADIIDDYGRYTTACAILETAERLAGEERAPAPKLHALTASALRAIAAKQRPHELVLDAYLLRAMRFAGWAPALDECAKCATPGPHRAFHVAAGGAVCVHCRPPGAATPAPGVLDHLVALARGEWAGIEAVPESTRKQASGLVAAHLQWHLERQLRTLPLIERSGPARDAATAGHAG
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: NAPA_SALPC
Sequence: MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPMLRMKDGSYHKDGEFTPVSWEQAFDVMEEKFKTSLKEKGPEAIGMFGSGQWTIWEGYAAAKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGSNMAEMHPILWSRITNRRLSDPNVKVAVLSTFQHRSFELADNGIVFTPQSDLVILNYIANYIIQNNAVNQDFFTKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFDEYKAFVAEYTLDKTAEMTGVPKDQLEQLAQLYADPNKRVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFSHRLPADMVVTNEKHRDICEKHWQIPAGTIPAKVGLHAVAQDRALKDGKLNVYWVMCNNNMQAGPNINEDRMPGWRDPRNFIIVSDPYPTVSALSADLILPTAMWVEKEGAYGNAERRTQFWRQQIKAPGEAKSDLWQLVQFSRRFKTEEVWPEALLAQKPELRGKTLYDVLFATPAVSKFPLSELKEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHNARGLRWPVVEGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAESPDNEYDLWLSTGRVLEHWHTGSMTRRVLELHRAFPEAVVFIHPLDAKARDLRRGDKVKVSSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNNLTLDATDPLSKETDFKKCAVKLAKV
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: VMT8_MYXVL
Sequence: MMSYPLYKLFLKGKLCDVEIVAEGKSIRAHRLVLSAYSKYFYNLFNGNFLEKNVDVIDLEADYKTVFDVIYYMYTESIELHKGNTESIFSLVHYLQIKPLIKKCIYEFNSIVNEENCIRLFKFAELYDLSELKRRARWLMPSLVMNEKDRLREMSLDDLSLMLVQIRNTVDRSIALSAITEWIQTNVRERRRHAVHLATCLGDVPGTASSRAVYKHYMSELRIRVTEFQPAYHNCVVYLGGSMKGRVTALDPETGKSVVLSTWWPEERWECFTAVCMNDVLYFAGGKLDAVPTRQVLSYDVKANTWSRQPNLSEFRSDAAAYAIGGCIYIIGGYDANDRPTNTTLYWRPGYDRWYRGPTLVEAVAETSAVCYKNEIWVLGGRIHRDGVPDVTDVVQKLSGGTWTKVNELSVPKASVTAIVYKERLYCVGGLVDRYAPTNEVIRYRDDTNEWEYVGSTKIERGGAVGCVYNDELYVFGGTDTFTSERYNGVIWKRANDVSCHFATMNAAYATYLEL
What are the official names of this protein?
Kelch repeat protein M-T8.
What is the protein family that this protein belongs to?
Belongs to the poxviruses Kelch family.
Protein: FABZ_STRA1
Sequence: MIDIKEIREALPHRYPMLLVDRVLEVSEDEIVAIKNVSINEPFFNGHFPEYPVMPGVLIMEALAQTAGVLELSKEENKGKLVFYAGMDKVKFKKQVVPGDQLVMTAKFVKRRGTIAVVEAIAEVDGKLAASGTLTFAIGN
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA3_ARATH
Sequence: MSSIGTGYDLSVTTFSPDGRVFQIEYAAKAVDNSGTVVGIKCKDGIVMGVEKLIASKMMLPGSNRRIHSVHRHAGMAVAGLAADGRQIVARAKSEARSYESVYGDAVPVKELSERVASYVHLCTLYWWLRPFGCGVILGGYDRDGPQLYMIEPSGISYRYFGAAIGKGKQAAKTEIEKLNLSEMTCKEGVIEVAKIIYKLHDEAKDKAFELEMSWICEESKREHQKVPDDLLEEAKTAAKTALEEMDAD
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-3, 20S proteasome alpha subunit G-1, DiDi 17A-2a, Proteasome component 8, Proteasome subunit alpha type-7.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TLP6_ORYSJ
Sequence: MSFRSLIQEMRDEFGSISRHSLRSRSHRGGGGAPRVAAVGPAEAAAMQQSCWAQLPPELLREVLVRIEESEVWWPSRRDVVACAGVCRSWRGITKEIVRVPEASGKLTFPISLKQPGPRDGTLKCFIRRNRTTQTYYLYIGLTEALADDGKFLLAARKCRKPTCTDYLISLDMSDMSKGSNTYIGKLRSNFLGTKFTVYDAHPPYDGAVVSKSRSARVVGLNQVSPRVPAGNYPVSHISYELNVLGARGPRRMNCIMDSIPTSAVQEGGKAPTQTEFPLSGLDSFPSISFFRSKSARIDSATSQLSTQKEEKLVLKNKSPRWHEQLQCWCLNFRGRVTVASVKNFQLVASDENGPTNQEQDKVILQFGKIGKDLFTMDYRYPISAFQSFAICLSSFDTKIACE
What are the official names of this protein?
Tubby-like F-box protein 6, OsTLP6, Tubby-like F-box protein 14, OsTLP14.
What is the protein family that this protein belongs to?
Belongs to the TUB family.
Protein: RL29_MYCBP
Sequence: MAVGVSPGELRELTDEELAERLRESKEELFNLRFQMATGQLNNNRRLRTVRQEIARIYTVLRERELGLATGPDGKES
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: Y3136_ARATH
Sequence: MAELLLVETPIPQQKHYESKPFPAVISPPSASIPIPALSLPLFTQTIKTQKHYLDSLLHESGAVLFRGFPVNSADDFNDVVEAFGFDELPYVGGAAPRTSVVGRVFTANESPPDQKIPFHHEMAQVREFPSKLFFYCEIEPKCGGETPIVLSHVVYERMKDKHPEFVQRLEEHGLLYVRVLGEDDDPSSPIGRGWKSTFLTHDKNLAEQRAVDLGMKLEWTEDGGAKTVMGPIPAIKYDESRNRKVWFNSMVAAYTGWEDKRNDPRKAVTFGDGKPLPADIVHDCLRILEEECVAVPWQRGDVLLIDNWAVLHSRRPFDPPRRVLASLCK
What are the official names of this protein?
Clavaminate synthase-like protein At3g21360.
Protein: NART_STAAS
Sequence: MYKTKGGFQLTLQTLSLVVGFMAWSIIAPLMPFIKQDVNVTEGQISIILAIPVILGSVLRVPFGYLTNIVGAKWVFFTSFIVLLFPIFFLSQAQTPGMLMASGFFLGVGGAIFSVGVTSVPKYFPKEKVGLANGIYGMGNIGTAVSSFLAPPIAGIIGWQTTVRSYLIIIALFALIMFIFGDTQERKIKVPLMAQMKTLSKNYKLYYLSYWYFITFGAFVAFGIFLPNYLVNHFGIDKVDAGIRSGVFIALATFLRPIGGILGDKFNAVKVLMIDFVVMIIGAIILGISDHIALFTVGCLTISICAGIGNGLIFKLVPSYFLNEAGSANGIVSMMGGLGGFFPPLVITYVANLTGSSHLAFIFLAVFGCIALFTMRHLYQKEYGSLKNG
What is the function of this protein?
Probably required for nitrate uptake under anoxic conditions.  Also possibly involved in excretion of nitrite produced by the dissimilatory reduction of nitrate (By similarity).
What are the official names of this protein?
Probable nitrate transporter NarT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APY2_ARATH
Sequence: MTAKRGIGRHESLADKIQRHRGIILVISVPIVLIGLVLLLMPGRSISDSVVEEYSVHNRKGGPNSRGPKNYAVIFDAGSSGSRVHVYCFDQNLDLIPLGNELELFLQLKPGLSAYPTDPRQAANSLVSLLDKAEASVPRELRPKTHVRVGATAGLRTLGHDASENILQAVRELLRDRSMLKTEANAVTVLDGTQEGSYQWVTINYLLRNLGKPYSDTVGVVDLGGGSVQMAYAISEEDAASAPKPLEGEDSYVREMYLKGRKYFLYVHSYLHYGLLAARAEILKVSEDSENPCIVAGYDGMYKYGGKEFKAPASQSGASLDECRRITINALKVNDTLCTHMKCTFGGVWNGGRGGGQKNMFVASFFFDRAAEAGFVDPKQPVATVRPMDFEKAAKKACSMKLEEGKSTFPLVEEENLPYLCMDLVYQYTLLIDGFGLEPSQTITLVKKVKYGDQAVEAAWPLGSAIEAVSSP
What is the function of this protein?
Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates.  Substrate preference is ATP > ADP.  Functions with APY1 to reduce extracellular ATP level which is essential for pollen germination and normal plant development.  Plays a role in the regulation of stomatal function by modulating extracellular ATP levels in guard cells.
What are the official names of this protein?
Apyrase 2, AtAPY2, ATP-diphosphatase, ATP-diphosphohydrolase, Adenosine diphosphatase, ADPase, NTPDase, Nucleoside triphosphate diphosphohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
Protein: YJIA_BACSU
Sequence: MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENWHTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL
What are the official names of this protein?
Uncharacterized protein YjiA.
Protein: LPXB_ANAD2
Sequence: MLYSPRLTDQILIVAGEASADLHAARTLHELQRLRPGITAFGVGGPRLREAGLEALAPAEDISVMGLAEVLPRIPRILGILRMLGRAAAERRPRAALLVDLPDFNLRLAARLKKLGIPVVYYVSPTIWAWRQGRAKKIARVVDRMLCILPFEERFYEGTGVSARFVGHPFAERPPPGPAEAYRSALGLPASRTTIAMVPGSRPSELKRLLPPMLQAAERLRAAHPDAQFVVPVAPTLDRAALEPYLAAHRTLEVRLVDGRTEEVVGASDAALVKSGTSTLEAGLMLRPMVVVYKLSWLSYAVARMLVKIAHVALVNILAGRGIVPELLQGDASPERMAAEVERLLGDRAAREAQIAALREVRASLGEPGAPLRVAEEVLGVMR
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: PHLA3_DANRE
Sequence: MNQCKVMNDGYLEKRSNGLLQLWKKKRCVLSDEGLRLYGCKGDSGKEMRFEQMTTLDCVEYKRGLVYFTIVMNDGKEVDFRCQQEGTAWNAEIALALVRFKNRVAVQTGRNRHLSHLGSCGEGDVEL
What is the function of this protein?
p53/tp53-regulated repressor of Akt/akt1 signaling.  Represses akt1 by preventing akt1-binding to membrane lipids, thereby inhibiting akt1 translocation to the cellular membrane and activation.  Contributes to p53/tp53-dependent apoptosis by repressing akt1 activity.  Its direct transcription regulation by p53/tp53 may explain how p53/tp53 can negatively regulate akt1.  May act as a tumor suppressor (By similarity).
What are the official names of this protein?
Pleckstrin homology-like domain family A member 3, TDAG51/Ipl homolog 1.
What is the protein family that this protein belongs to?
Belongs to the PHLDA3 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: DIS1_SCHPO
Sequence: MELDDFNSRILSQIFDKSWKVRFEAYESLLHALNRALDDSDVCFQPWIHDPALWKQGLCDSNVPTQEHAVKSLRCFLDKSRQKGVNSAKSFVVAPLLEKCLPSPRQSIRDASHQALLILAKSDALDYVLEGLFSAARVKHPKQAVASIKELNSLLENFGIPALSPIPFYKLIPTLFAQSDKNIRQEASNLSITLYAWVGNAFKTHVFPQLKQIQVSDLEASFQNVTSRTTTGGHISNSLNTQEVVLPSFSSNAKPKPHLSSKSSSQGNTLQRSTSSFSTPNRKVSQPSDFSASPSRSIVSPAKNIVGSTPVDVLSKLTPEFHTALSSPKWKDRKEALESMVPVCSNPVYQEGDYSELLRVIAKSLKDANVVVVGVAALLLTHIAKALRKGFLPYTGIVLPSLFDRFKERKSSLVHSLLDAANAIFESCGLNDIMDETLEFLKHKNPQVKTETLRWLNRCLQLTDVCPPRASLETLCSLCVTLINDTFEPVRMATTNVLATLVQIFSQPVLSKYIVGLDPKKLPKILELSKDITVNAHPNQPSRPRLPRVASPLKTSPVKLAVTPQAPSPLPSSNPSQASLTEESLSTRSSPTKPSTTSLRSQSLVNRFASSTLKAPSSSSKGVSNAASSKQSFPSSPSISKKLETSRLSTKKLPGSTMKAASALKEYPQQQSMKSGGEKQDNLVTITMSEKVELDLLREEKAIRQVQEAEDALERERLFREINDLQIQNAEMKEQVYEKESTISQKEVEITSLRNEKDRLSTRLQQVLLELEKQHETNEEAMDIDLKVPESGAIGRVTTRATATTAMDESGNAGMVSSGIHSVSTKPSSYGTRRSLAGSMLQKPTQFSRPSFMFSPEARDNWRESHDLSSHLWEQIQRMKKA
What is the function of this protein?
Has a role in sister chromatid separation.
What are the official names of this protein?
Phosphoprotein p93.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm, cytoskeleton, spindle. Note=Spindle pole body during metaphase and spindle microtubules during anaphase.
Protein: PI51B_RAT
Sequence: MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKEREKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHILDHSLKDKEEEPLQNAPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPAKSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEILSSISQEWKDEKQDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSSTFTLEEGTIYLTAEPNALETQDDASVLDVYL
What is the function of this protein?
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity).  PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity).  Mediates RAC1-dependent reorganization of actin filaments.  Contributes to the activation of phospholipase PLD2.  Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity).
What are the official names of this protein?
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta, PIP5K1-beta, PtdIns(4)P-5-kinase 1 beta, Phosphatidylinositol 4-phosphate 5-kinase type I alpha, PIP5KIalpha, Phosphatidylinositol 4-phosphate 5-kinase type I beta, PIP5KIbeta.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane. Endomembrane system. Note=Associated with membranes.
Protein: WIPI3_PONAB
Sequence: MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEKEKQEFLEGGVGHVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEVKAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSGHLIQELRRGSQAANIYCINSNQDASLICVSSDHGTVHIFAAEDPKRNKQSSLASASFLPKYFSSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSYYKFLFNPKGECIRDVYAQFLEMTDDKL
What is the function of this protein?
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.  Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2.  In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway.
What are the official names of this protein?
WD repeat domain phosphoinositide-interacting protein 3, WIPI-3, WD repeat-containing protein 45B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure. Lysosome.
Protein: ODPA_RAT
Sequence: MRKMLAAVSRVLAGAAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFNRGHAVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHE1-A type I.
What are the subcellular locations of this protein?
Mitochondrion matrix.