PharMolix/UniProtQA huggingface dataset:
Protein: ISPD_HUMAN
Sequence: MEAGPPGSARPAEPGPCLSGQRGADHTASASLQSVAGTEPGRHPQAVAAVLPAGGCGERMGVPTPKQFCPILERPLISYTLQALERVCWIKDIVVAVTGENMEVMKSIIQKYQHKRISLVEAGVTRHRSIFNGLKALAEDQINSKLSKPEVVIIHDAVRPFVEEGVLLKVVTAAKEHGAAGAIRPLVSTVVSPSADGCLDYSLERARHRASEMPQAFLFDVIYEAYQQCSDYDLEFGTECLQLALKYCCTKAKLVEGSPDLWKVTYKRDLYAAESIIKERISQEICVVMDTEEDNKHVGHLLEEVLKSELNHVKVTSEALGHAGRHLQQIILDQCYNFVCVNVTTSDFQETQKLLSMLEESSLCILYPVVVVSVHFLDFKLVPPSQKMENLMQIREFAKEVKERNILLYGLLISYPQDDQKLQESLRQGAIIIASLIKERNSGLIGQLLIA
What is the function of this protein?
Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522420, PubMed:27130732, PubMed:27601598, PubMed:26687144, PubMed:22522421, PubMed:26923585).  Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:27130732, PubMed:26687144, PubMed:26923585).  CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:27130732, PubMed:26687144, PubMed:26923585).  Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144).  Not Involved in dolichol production (PubMed:26687144).
What are the official names of this protein?
D-ribitol-5-phosphate cytidylyltransferase, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein, Isoprenoid synthase domain-containing protein, hISPD.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HIS4_BACC3
Sequence: MEIFPAIDLKEGRCVRLYQGEFSKETVMNEDPVAQAIIFEKFGAKRLHIVDLDGAVAGESLNLSVIERICKAVRIPVQVGGGIRSLVAVEKLFSVGVDKVILGTAALYDKTFLEEAVLLYKEKIIVGIDAKNGFVATRGWLDVSEISYIDLAKQMENIGVQTIVFTDISKDGTLAGPNIGQLELLQKSVAIRLIASGGVASIQDVKKLNDMNIYGVIIGKALYEKTIDLEEVLEVTKLC
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPCKG_METMP
Sequence: MYLLNDKVAHELKKPFGKVYKELPSIEGKVVSIGDVTTKHLLSNGIIPDLSILDFKTKRNIPVDIPHKFKTIFEVENPQGCISDEAIERIKYLSTIHDRDMALIIKGEEDLLTIPVIKYFPEDTSVIYGQPDEGMVLLKITDELKQKIEKLLKEMEER
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.
Protein: RL111_CAEBR
Sequence: MTDIEKQTEIREKKGRNVMRELKIQKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRTFGIRRNEKIAVHCTVRGPKAEEILEKGLKVKEYELYKENFSDTGNFGFGVQEHIDLGIKYDPGIGIYGMDFYVVLNRNGVRVSKRRRAPGRIGPSHRVDKEETIKWFQQKYDGIILPPKPKTKKNVYRRR
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L11-1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RNZ_TREPA
Sequence: MHMNLEAFILGCGGMVPLPHRHLTSVLLRREGELFLFDAGEGTQVSLRRLSLRWKKISAIFISHTHADHITGLPGLLMLSSQVARSEPLYIIGPPRTAEYVETSRRILDMYINYEIIVKEVIEPQVVYRGKDFQVRCFCLDHTKPCMGYTLEEQDRPGSFDPRAAQDLHVPCGALWSQLQSGVAVQSAQGVTVYPEQVMGPARPGRKVSFVTDTKYLQSIAAEVRNSDFFVCEGMFEKGMEKDAAEKKHMTCVQAATIARDARVRLMALIHYSPRYTDHELKRLLKEAQRVFPHTILSRDQLMVPIAYRE
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: TRPA_BACC3
Sequence: MGVERIKAAFENGKKAFIPYVMGGDGGLEILKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFIENCMEAGVDGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERIKKIMSESEGFVYAVTVAGVTGVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICEFIQATKQKEEA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: NDUF7_BOVIN
Sequence: MNFLAAAGVRRLCAMRAVLPCLWRGKYFSSGNEPAENNTVTPMLRHLIYKIKSTGPITVAEYMKEVLTNPAKGYYMNRDMLGEEGDFITSPEISQMFGELLGIWFISEWIAAGKNAAFQLVELGPGKGTLLGDILRVFSQLGSLLKNCDISLHLVEVSQKLSEIQALTLTEEKVPLERNAESPVYMKGVTKSGIPVSWYRDLQDVPKEYSFYLAHEFFDVLPVHKFQKTPHGWREVLVDIDPQVSDKLRFVLAPCATPAGAFIQNDETRDHVEVCPEAGVVIQELSQRISLTGGAALIADYGHDGTKTDTFRGFCGYRLHDVLTAPGTADLTADVDFSYLRRMSQGKVASLGPVEQQTFLRNMGIDVRLKILLDKTDDPSLRQQLLQGYNMLMNPMKMGERFNFLALVPHQRLHGRNHQTNARQSKPSPSPVAGFGELAWQ
What is the function of this protein?
Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).  Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex.
What are the official names of this protein?
Protein arginine methyltransferase NDUFAF7, mitochondrial, NADH dehydrogenase [ubiquinone] complex I, assembly factor 7, Protein midA homolog.
What is the protein family that this protein belongs to?
Belongs to the NDUFAF7 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LARC_ALKMQ
Sequence: MSNQLYLECYSGISGDMAVSALLDLGADVDVLKKSLHSLNLEGYEINIGRRQKCGIDACYFDVVLEGEANHHHDHQEKHDHHHGGHPVHRNIKDIYEIIDNSQISDRSKILSKKIFHVVAKAEAKAHGIAIDEVHFHEVGAVDSIVDIVAAAVCLDNLEINEVMISDLYEGSGHVKCQHGVLPVPVPAVANIVMDNGLNLRITDTRGELVTPTGAAIAAAIKTKDTLPASYGIKKIGIGSGTKDLPKANILRAYIIEDNRNYPKKTVAVEDHIDSLDDGEAWVLETNIDDATGESLGFTMERLLENGANDVFFSPIYMKKNRPAYKLSVICTKENVKIMESIIFKNTTTIGIRKHKIRRTVLKREVTTIDTKYGQVRVKVCEFENETYYYPEYEDIKRICNETGLGFQRVYDEVEKTKTVG
What is the function of this protein?
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex).  Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor.  Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
What are the official names of this protein?
Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein, P2TMN nickel insertion protein, Nickel-pincer cofactor biosynthesis protein LarC.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: RS14_AEDAE
Sequence: MAPRKNKTVKEEVQVSLGPQVREGEIVFGVAHIYASFNDTFVHVTDLSGKETISRVTGGMKVKADRDEASPYAAMLAAQDVAEKCKSLGITALHIKLRATGGNRTKTPGPGAQSALRALARSSMKIGRIEDVTPIPSDSTRRKGGRRGRRL
What are the official names of this protein?
40S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: AKH_LIBAU
Sequence: QVNFTPSW
What is the function of this protein?
This hormone, released from cells in the corpora cardiaca, causes release of diglycerides from the fat body and stimulation of muscles to use these diglycerides as an energy source during energy-demanding processes.
What are the official names of this protein?
Adipokinetic hormone, AKH.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMD_NEIG2
Sequence: MLIQAVTIFPEMFDSITRYGVTGRANRQGIWQFEAVNPRKFADNRLGYIDDRPFGGGPGMIMMAPPLHAAIEHAKAQSSQTAKVIYLSPQGKPLTHQKAAELAELTHLILLCGRYEGIDERLLQSSVDEEISIGDFVVSGGELPAMMLMDAVLRLVPGILGDIQSAEQDSFSSGILDCPHYTKPLEFQGMAVPEVLRSGNHGLIAEWRLEQSLRRTLERRPDLLEKRVLIPKESRLLNKILQEQREIQS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOSL_DROVI
Sequence: MMKNLNGRTHNACYQPYYQQQLQLQQQHQQQQQLQQQQQLLQQQQQLQLPYAAPYNQLQQQQYTQQQYYQQQLQQQQQQQQQQQQQLLRQQQPTLSVYQQQQHAKQSYGHNNSNNNANMTQTARSNMQTASIATVSANGNNSSSSSSNANAANSATAAMAAMCQMQSFLSQQQQQQQQQQQQQQQQQQQQYHNNCAHINYNQQQQQQQQQLQQQQLSTAATTNGDKLALDNASEIANFLASELFMQQLVTFDGMQSAPTLTTPTLTPTTLRTIEETIYELTTEPQIVPFQAGFKPPPLTSLGAITNNNTVTPTTAAAAAAATLAVVNANPINANPQFDLLGLNCNSVRGSDTEDSNGSWNDGQLNDDQSTTDTSSAATDSTSYQNGGHMLGNGSNGGVNNFTVALAAVNNAGRASGQAGGNSTTSNSGTPARRGGGRRPNKAANMSPEEEEKRRIRRERNKLAAARCRKRRVDQTNELTEEVDALIKKGEDMKKEIENLNATKNQLEYVLQAHRPTCQKVRNDLLSVVTCNGLIAPTTLLSAGSCTGTGSQHSNNNNNNSSNNNNSNSSNNNNNNSNSNDSSSGGTITGFDATLNSTGRSNSPLDLKPVLTDEQLLQHIKNEPQDVGLDSSSSLDQDGPPPAKRCFALPNIAALTASLTTPTDPGSCSLNTPITSTAPNIFANFGGDLNSPTLNALNKLPKARPNTLNVQQLQRPFVVQQLGNDGNKAPPTQIQGVPIQTPSTGTFNFDSLMDGGTGLTPVSGPLVPTCSSQNKHPLELPTPTSEPSKLVSL
What is the function of this protein?
Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'.  May play a role in the function or determination of a particular subset of cells in the developing embryo.  It is able to carry out its function either independently of or in conjunction with Jra (By similarity).
What are the official names of this protein?
Transcription factor kayak.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Fos subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: JIP5_DEBHA
Sequence: MAKKKKSNATNAARLLESSISPIVEIKYPEPLFTIAAHPTKPILLSGLATGHIYCSTYDADILEEAQSTKREKLSLLEKEAFKTGKIAHINRSVSQSKQKWWTVIEDNADIPDGSNIVNNWKTKRHKGSCRSAIFDPLENSLGENIYSVGTDHIIKKANTETGKVLSKATISEHYSDKNDAITKLVHSTSHPFLLSGTENGDVLVYDSNNMASNQLKFNVSKAHDDSINHILPMPAVSAYHYLTLGSTTLSHIDIRKGIITQSDDQEDELLSMCFASDHVNDNKNDTVLVSHGEGIVTIWKNSKNRLMDQLSRIKVNKEASIDAIIPTMNCDDGEMVDSVWCGDSEGLLHRINYKKGKVVETRVHSSAAGKHGPADEVGILDIDYDYRLISAGMDSLKIWSNQEETLNSDSDDSDSDDSDSDIGSNDSEDSDSDDDDVAINNKIEDEVNDFSPDSDSETGNDDSDENLEDVADSDSNEDQIENVTDEEHQLSDTELPTKSLQIIRKKRFNVPEISNKTNINKKVVDINKLTKEQSTKKADEEPEETEEPDKKKQKLKAKQMSTKQIRNMQKHEHGIRRFDDL
What are the official names of this protein?
WD repeat-containing protein JIP5.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR55 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL18_SHEPW
Sequence: MDKKTSRLRRATRARKKIQELGVNRLVVHRTPRHTYAQVISPANVVLAAASTAEKAVSEQLKYTGNVDAAKAVGKTVAERAIEKGVAVVAFDRSGFKYHGRVAALADAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: O16E_CONBU
Sequence: AACQLGTAASFARDKQDYPAVRSDGRQDSKDSTLDRIAKRCSEGGDFCSKNSECCDKKCQDEGEGRGVCLIVPQNVILLH
What are the official names of this protein?
Conotoxin Bu14.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACEA_PSEAE
Sequence: MSAYQNEIKAVAALKEKNGSSWSAINPEYAARMRIQNRFKTGLDIAKYTAAIMRKDMAEYDADSSVYTQSLGCWHGFIGQQKLISIKKHLKTTNKRYLYLSGWMVAALRSDFGPLPDQSMHEKTAVSGLIEELYTFLRQADARELDLLFTGLDAARAAGDKAKEAELLAQIDNFETHVVPIIADIDAGFGNAEATYLLAKKMIEAGACCIQIENQVSDEKQCGHQDGKVTVPHIDFLAKINAVRYAFLELGVDDGVIVARTDSLGAGLTKQIAVTNEPGDLGDLYNSFLDCEEISESELGNGDVVIKREGKLLRPKRLASNLFQFRKGTGEDRCVLDCITSLQNGADLLWIETEKPHVGQIKAMVDRIREVIPNAKLVYNNSPSFNWTLNFRQQVFDAFVAEGKDVSAYDRNKLMSVEYDDTELAKVADEKIRTFQRDGSAHAGIFHHLITLPTYHTAALSTDNLAKGYFADEGMLAYVKGVQRQELRQGIACVKHQNMAGSDIGDNHKEYFAGEAALKASGKDNTMNQFH
What is the function of this protein?
Involved in the metabolic adaptation in response to environmental changes.  Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.
What are the official names of this protein?
Isocitrate lyase, ICL, Isocitrase, Isocitratase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Protein: HIS1_ALKCK
Sequence: MTLTMAMPKGRIFEEAVQLLRSAGYNLPSSFEQSRKLIIDVPNESLRFILAKPMDVPTYVEHGVADVGVAGKDVMLEEKRDVHEVLDLNISACHLAVAALPTYQRGELNPKVASKYPNVASQFFKEQGEQVEIIKLNGSIELAPIMGLAGRIVDIVSTGQTLKENGLVELEQIRKITSRFIVNPASYRMRAGEIHDMVERLATVIEGDGSEDH
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGALB_ASPNC
Sequence: MRWLLTSSALLVPAAALVRPDGVGRTPALGWNSWNAYSCDIDADKIVTAANEVVNLGLKDLGYEYINIDDCWSVKSGRNTTTKRIIPDPDKFPNGISGVADQVHALGLKLGIYSSAGLTTCAGYPASLGYEEIDAQSFAEWGIDYLKYDNCGVPTNLTDQYTYCVPDSTDGSNYPNGTCVNLTDAAPQGYDWATSTTAKRYQRMRDALLSVNRTILYSLCDWGQADVNAWGNATGNSWRMSGDITATWSRIAEIANENSFLMNYANFWGYPDPDMLEVGNGNLTLPENRAHFALWAMMKAPLIIGTPLDSIDTSHLTILSNKPLLTFHQDAVIGRPAYPYKWGYNPDWTFDPEHPAEYWSGPTSSGEVFVLMLNSEGEVKTRSAVWEEVPELKDRGTKKNSKEKKGFKVTDAWTGKDLGCVKDKYEVKLQAHDVAVLVVGGQC
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase B, Melibiase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PROB_RUEST
Sequence: MAALSTARRVVIKIGSALLVDRTSSALRQEWLLSLAEDVARLKKQGKDVILVSSGSIALGRGALGLPRKDLPLEQSQAAAAVGQIRLARAYEEALAPHGITTAQVLVTLEDSENRRRYLNSRATLETLIGLGAVPIVNENDTIATDEIRYGDNDRLAAQVAVTVGADVLILLSDVDGFYSANPALDPDAKRFDRIEQITPEIEAMAGDGVSGLSKGGMITKLLAAKMATAAGCAMAISEGSVMSPVSALEAGAASTWFTAQGDPQVARKRWIAAMKTRGVITVDEGAAKALHNGNSLLPAGVRHVEGDFGRGDPLAILGPDGRKLGQGLSRYTAEEARALQGHRSDEIEAILGYAGRAALIHRDDMAL
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3186_YERPS
Sequence: MSIENTLPTYPSLALALSQQAVALTPAEMHGLISGMLCGGSKDNGWQTLVHDLTNEGVAFPQALSLPLQQLHEATQEALENEGFMFQLLIPEGEDVTVFDRADALSGWVNHFLLGLGMLQPKLAQVKDEVGEAIDDLRNIAQLGYDEDEDQEELAQSLEEVVEYVRVAAILCHIEFTQQKPTAPEMHKPTLH
What are the official names of this protein?
UPF0149 protein YPTB3186.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: CXA4_XENLA
Sequence: MGDWEFLEKLLDQVQEHSTSIGKIWLMVLFIFRILILGLAGESVWGDEQSDFTCNTEQPGCTNVCYDKAFPISHVRYWVLQFLFVSTPTLFYLGHVIYLSRKEEKLKQKESELRALDDKEQVEQAIAIIEKKKLKLYIQEDGTVKIKGALMYTYLTSVIFKSIFEAGFLLGQWYLYGFVMTPIYVCERVPCPHKVDCFVSRPMEKTIFIIFMLVVSLISLFLNVLELIHLICKSMIHALKKYSQYIPANRYPKNEDTYPEKTSETATAPFQDKSYIYLPMNENISYPQYKMPNEQNWVNFNTEQQLAISGNTQSPLGHYSLSAFLPVSPKTHSTVEKASTRASSSASKKQYV
What is the function of this protein?
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
What are the official names of this protein?
Gap junction alpha-4 protein, Connexin-41, Cx41.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: KDM5D_PANTR
Sequence: MEPGCNEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKNPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYTLQSFGEMADSFKSDYFNMPVHMVPTELLEKEFWRLVSSIEEDVTVEYGADIHYKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLAQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQDEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSLIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGALQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRHLAELRQQLQAKPRPVYTSATACDPIREGSGNNISKVQGLLENGDSVISPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRQQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPSLKGNQNSLQHKDSGSSAACPSLMPWLQLSYSDEQQL
What is the function of this protein?
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code.  Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'.  Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.  May play a role in spermatogenesis.  Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8.  Suppresses prostate cancer cell invasion.  Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks (By similarity).
What are the official names of this protein?
Lysine-specific demethylase 5D, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, [histone H3]-trimethyl-L-lysine(4) demethylase 5D.
What is the protein family that this protein belongs to?
Belongs to the JARID1 histone demethylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACBD4_RAT
Sequence: MGTEKEEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATAGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWQEPAVNRDVQAAPEPSHPPKEPAPPSPESRLPRDLDLEVFCDSVEQLEPELVRVPVLSPVPAESELPHLHTGTGDSAQRVWAEQKEAAGRELTTRSSPESPEGFGGSLMGPQELDRWLVGTVQAMQESMKDVHRRLQILESKPQPLEQQRSPRTRPWPLGLSTPTLLFFILWPFVVQWLFRQFRTQRR
What is the function of this protein?
Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
What are the official names of this protein?
Acyl-CoA-binding domain-containing protein 4.
Protein: VAPC_SALTY
Sequence: MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHTGQIRAELARKGTPVGPYDQMIAGHAGSRGLVVVTNNLREFERIPGIRIEDWC
What is the function of this protein?
Ectopic overexpression in E. coli induces the YoeB toxin, but this is not the cause of VapC toxicity.
What are the official names of this protein?
tRNA(fMet)-specific endonuclease VapC, RNase VapC, Toxin VapC.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: RL24_CERS5
Sequence: MAAKLKKGDRVVVLAGKDKGKQGEITSVMPKDNKAVVEGVNIAIRHAKQTPTSQGGRIAKAMPIDLSNLALLDANGKATRVGFRFEGEKKVRYAKTTGDVI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: HFQ_MARMM
Sequence: MSHDKKQNLQDVFLNSVRKTKTPLTIFLVNGVKLQGVVTWFDNFCVLLRRDGLSQLVYKHAISTIMPAAPVSLFEDDKADDDAAEESATD
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: VP2_RRSVT
Sequence: MTEYTNLPVKWTNGIVISDERMMLDPLPSEVSAVLDAPINYSYRYNELRRTHSLKLFGVWSGYIPSHADKHLMIFQLLQQEKELTGDEIRLALRQMQGSIKLPINDKLLDSLDRYSLIFAWIAYAGCLDSAFWQQVCADPKCLVYNPDDNLKFSLMFSLARQYSATTRICSADGLRIPSQISPDLGQLAFDLVFNSSVRQTVWFHANDFPAFDFYTKDVGTMVTFHVNFLYNMTHCVPFKTKQSCAEYLIQKAHEAWSVYCGVLNDTIRHRLRLVEGVGIVTLDVDLQILAAVGWYLPLLVYTIRSVSGSDISEWLNVARREFRDLNCSSMINGEGYVGVPEQFWTIHATSKARMWPRVKKYTCDLTDLYNGDLSSTVLGEGASETGTVKWFDVPLGPKVENFRVVGTRIGALSRANVIYNYEDPSDNCDLARAIGSFVPSLPTSGTRDTNGDLEDAKKMFDYRVSQNVYSICQKGKISSLVSRSVKNLRASLMNGELRVYKGSRLWALRAMLFSDKLRYKSDGQVIDPYESHRGKITVRLNNSSLKMLSAFVTLIELAMAQSSGVEDNMLNGRGLSPLQVRSDREVSRVVIAGAINEPLVGCLRRMYPKLSVIGFGMDAVGENERLTVEGASQRNLACDMLISDIDQTFYSDFTKMCNVTVKHALAFSSWSDYVLMKVNYPSSHLLNEIKQALLSRGFSRIVLPVVMCGQNSFTSEVFVYIGRAGVGGHVDFKNNWFTKNDILMRRYRHMKAPLITIPQVVHSVVSKCVTKHDTELFANPGSIVALTVEYASAREVVSLISEVCSPVWTWRTGAGANKFVNIVGMPSKARAALTRRTDEHYYLKAFERNIVGTSFGMYKGIPRIDALNCVSWVTIFGAAMRECLYWIVDTLKVQYNEVISIGARNMTDIEFIKPSVKLTCYDEYYANPQDLATHYNVNYENKYFNWLSPTLVNDSVYVANFVIMAPTEGSESPSATEQLDRIDSVAGAMAKSSITRMTFVGNLYDSRFLADIALSSLPPEGLKVNDTRTTVQIGKYPPCAAVKPSAFLERMKKYKGVLSYHVYPLGYDRVLKTCADNLWIPDVAGSPMLAFCQGLSYAFYITKPAIPDEGIDQFMLDDMPDDGSGSVTPTQSPSPSPSPSAAANTEASTVVEPIDNLNVVSPTVPGQPSQTPVNPNQSTELQSVAKPGIVR
What is the function of this protein?
Outer capsid protein involved in mRNA capping.  Catalyzes the last 3 enzymatic activities for formation of the 5' cap structure on the viral plus-strand transcripts, namely the RNA guanylyltransferase, RNA-7N- and RNA-2'O-methyltransferase activities (By similarity).
What are the official names of this protein?
Outer capsid protein VP2.
What are the subcellular locations of this protein?
Virion.