PharMolix/UniProtQA huggingface dataset:
Protein: GLYC_CPXVB
Sequence: MGQLVSFFQEIPVFFQEALNIALAVVTLLAIVKGVLNLWKSGLFQLLMFLILAGRSCSFRIGYHTSFESFTMTIGGVFHELPALCKVNDTYNLVRLSHNSSLALSVEYGDTGTVMCEHGHVVSGNYTECTGASEEYNWVLDWVLRGLQHDFSRDPVICCEPKKKTNAEFQFRLNLTQRHKGDHYQNKIKTALTHLFGPFAYNEKDPKIFVTMRNTTWTNQCVMSHTDSLRLLASNGGNSFSGRGLKAFFSWSLSDSTGVDMPGGYCLEKWMLIASELKCFGNTALAKCNLKHDSEFCDMIKLFDFNKNAISKLNNNTIEAVNQLTKTVNSLISDNLLMKNRLRELLKVPYCNYTRFWYVNHTRTGEHSLPKCWLVNNGSYLNESDFRNEWILESDHLISEMLSKEYQERQGRTPLTLVDLCFWSAVFYTTTLFLHLVGFPTHRHISGEPCPLPHRLNRHGACNCGRFKRLKKPLVWYKHH
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: PSUG_FERNB
Sequence: MIISEKVKKALEDGIPVIALESTVIAHGLPYPHNVETAKMLEEMALENGVVPATIGILKGEIIVGMSQEQINEMLADEPLKIGTREIPYAVGMKKSAATTVSATMRIAKIAGIDVFATGGIGGVHIGDWDVSQDITEMAKSDVIVVSAGCKSILDVKKTIEFLETFQVTVVGYKTNKFPIFYEGLSDFNLEHRVDSPEDIAKIFRAKKSLGIEGALLVANPIPQEFVISEQEVDGYMKQALSECFEKGITGKAVTPYLLSRIAQLSNGKTLTSNIELLKNNVLLACQIAKSLKTMA
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: CRYAB_RABIT
Sequence: MDIAIHHPWIRRPFFPFHSPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWIDTGLSEMRLEKDRFSVNLDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQAPGPERTIPITREEKPAVTAAPKK
What is the function of this protein?
May contribute to the transparency and refractive index of the lens.  Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.  In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).
What are the official names of this protein?
Alpha-crystallin B chain, Alpha(B)-crystallin.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Lysosome. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. Localizes at the Z-bands and the intercalated disk in cardiomyocytes. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: KTND_ASPNC
Sequence: MPSNYTQHVGNHDFTRATVVIIGAGVSGMCMAIDLLHRTPIRKFVILEQGSSVGGTWANNLYPGCASDVCSSLYSYSFEQRPDWAAEYPGQEEFLTYMTDVAQKHGLYKYIRFNSTVQEARWDDKQQQWKVKVALNSAKASEFHEQYELTTNFLVSAVGQLNVPSYPSISGLDDYTGKLIHSARWDWTYDFSGKRIGVIGNGASAIQIVPELAKTASHITIYQRSPKWLLPRSNKKIGAIQHFLLSYVPPLRWCKRILQMRYREWLYNVLVTPGTVPARQFEAQSQEWMKSQLPDKPELWDTLTPNYAIGCKRVLISDDFYAALNASHVDLNTRPIQRITATGVQTDDDEQEYDLIVLATGFRASEFLHPIRVYGAGGRSLEDIWKDGPRAYYGMTVEDVPNFGMLYGPNTNLGHNSVITMIEAQSRYLSTMIRAVADAKKKDQTLVIQPRPEVLREYNERVQKHLAETSFADPNCQSWYKTDEGLITNNWPSTVVRYQKEVSQVRWADFILKGSGSAAVAKKKATYVGRVKEEALVSNVTLFLGVALAAGGVYWRATSWWKWEVPLIDKVGDDGILYGSGKTAWTSRVCPGAHCASGLLRILSLRRA
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the bicoumarin kotanin (PubMed:22945023, PubMed:26389790).  The non-reducing polyketide synthase ktnS first catalyzes the formation of the pentaketidic 4,7-dihydroxy-5-methylcoumarin from acetyl coenzyme A and 4 malonyl coenzyme A molecules (PubMed:17315249, PubMed:22945023).  Further O-methylation by ktnB leads to the formation of 7-demethylsiderin (PubMed:17315249, PubMed:22945023, PubMed:26389790).  Then, an oxidative phenol coupling catalyzed by the cytochrome P450 monooxygenase ktnC forms the 8,8'-dimer P-orlandin via dimerization the monomeric precursor, 7-demethylsiderin (PubMed:26389790).  P-orlandin is subsequently O-methylated in a stepwise fashion to demethylkotanin and kotanin (PubMed:22945023).  The function of ktnD within the pathway has not been determined yet (PubMed:22945023).
What are the official names of this protein?
FAD-binding monooxygenase ktnD, Kotanin biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL24_CITK8
Sequence: MAAKIRRDDEVIVLTGKDKGKRGKVKNVLSSGKVIVEGINLVKKHQKPVPALNQPGGIVEKEAAIQVSNIAIFNAATGKADRVGFRFEDGKKVRFFKSNSETIK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MANF_EMENI
Sequence: MKRQALTLIPLLGAAAAQSGPYGQCGGNDWSGATTCVSGYVCVYQNEWYSQCVPGTATSSSTTLTTTTSATTRTTTTTTSTTSVPSSTNFPSASGLNFTIDGVTDYFAGSNSYWISMLTNDADVDLVLDHIASSGHKILRIWGFNDVNTEPSTGQVWFQKHQGGVSTINTGQYGLQRLDAVVSSAEKRGIKLIINFVNNWDDYGGMSAYLNAYGGSTKTDWYTSATIQAAYRTYIKAVIDRFIDSPAIFAWELANEPRCNGCDTSILYDWIADTSAYIKSLDPLHMVCIGDEGFGLDEGSDGSYPFSYNEGLDFAANLAIDTIDFGTFHLYPGSWGVSYDWGNLWAITHGAACATAGKPCLFEEYGAPSDHCAIEVPWQTTAVSSTGIAGDLFWQWGDTLSTGQTHNDGNTIYYGSDEYTCMVTEHMERIAAR
What is the function of this protein?
Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.
What are the official names of this protein?
Probable mannan endo-1,4-beta-mannosidase F, Endo-beta-1,4-mannanase F.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: AMY2_SCHOC
Sequence: MKFATILSTTALALSSLVASKPIFLSKRDAGSSAAAAWRSESIYQLVTDRFARTDGSTSATCNTGDRVYCGGTFQGIIDKLDYIQGMGFTAIWISPVVEQIPDDTGYGYAYHGYWMKDIYAINSNFGTADDLKNLSNELHKRNMKLMVDIVTNHYAWNGAGSSVAYSNYNPFNQQSYFHDYCLITNYDDQTNVEDCWEGDNTVSLPDLRTEDSDVSSIFNLWVAELVSNYSIDGLRIDSAKHVDESFYPSFQSAAGVYLLGEVYDGDPAYTCPYQNYMSGVTNYPLYYPMLRFFQGTSNSVDELNAMISSLESDCKDITLLGNFIENHDQPRLPSYTSDSALIKNAIAFNLMSDGIPIIYYGQEQGYSGSSDPNNREALWLSGYSTSNGYYKLISSVNQIRNQAIYKDSKYTTYWSDVLYASGHVIALQRGADDQRIVSVFNNLGSSGSQTVTFSTKYSGGEKVVDVLTCQTSYANSDSTLTVSISGGAPRIYAPASLIANSGICNF
What are the official names of this protein?
Alpha-amylase 2, 1,4-alpha-D-glucan glucanohydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: MPSF_MACPH
Sequence: MISVSDKNEVKRIIHTEDWPKSELIYGNFRQNPARPTLIAFTDKKAYAERKRLISGWFGLRYIRSLQPLMQQCINESIASIERAIDTAGGIVDMQNLCTGTAVDIIGTTIFGQSFDVVKNGSHPLPDYLRKMLKASGLLLFMPWIRSIPFRPTRPAYIDRFTLDIMEKRRATAKSAPRQDLLQKLVEQLDDAAGSKFTPFDVQGEVTIMLVAGTETTANSELFTLLMLVRHPDKLRRVYAEVDAWYPPGDLATPVDCEYSLQGMTYLQACEDEAMRLVPAQATGSPRESRRDEVVLGYRVPAGTTVFPTTQGVHHDESVWKDASEYVPERWLEIYEKGKVTEQHFWPFSAGSRVCIGKHFALQEMHLMLVNLLRRFEFEYVPGQPETTVFRVAQHMEAPKYVMKVRRRKF
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of macrophasetins, 3-decalinoyltetramic acids (DTAs) which feature a tetramate (pyrrolidine-2,4-dione) unit connected to a decalin fragment and that have potent bioactivities (PubMed:36452919).  The PKS-NRPS mpsA together with its associated enoylreductase partner mpsG incorporate one unit of acetyl-CoA, seven units of malonyl-CoA, and one unit of L-alanine to assemble the linear tetramic acid intermediate corresponding to the backbone of macrophasetins (PubMed:36452919).  Without the Diels-Alderase mpsD, the mpsA/G product can undergo the non-enzymatic intramolecular Diels-Alder (IMDA) reaction to generate both macrophasetin A and macrophasetin B (PubMed:36452919).  Catalyzed by mpsD, the linear tetramic acid intermediate is thoroughly converted to macrophasetin A via the endo-IMDA reaction in a regioselective and stereoselective manner (PubMed:36452919).  Finally, the cytochrome P450 monooxygenase mpsF catalyzes the hydroxylation at C20 to yield the end product macrophasetin C (PubMed:36452919).
What are the official names of this protein?
Cytochrome P450 monooxygenase mpsF, Macrophasetins biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: GSA_THEYD
Sequence: MKTTKSKKLYKQALKLMPGGVNSPVRAFKAVGGNPLFIAKAKGSKIYDVDGNEYIDYVLSWGPLILGHAYPSVVKALKKAIEKGTSYGAPTELEIKLATLVKKAFPSIEKLRFVNSGTEATMSAIRVARGFTKRNKVIKFEGCYHGHVDGLLVSAGSGGATFSIPDSLGVPQSYTSETIVLPFNDINTFKNTLKEHWKDIACVIVEPVVGNMGCILPKDEFLKVLRNETQKYGIVLIFDEVMTGFRVSFGGAQQYYGVKPDLTCLGKVIGGGLPVGAYGGKKEIMALVAPDGGVYQAGTLSGNPIAMTAGIETLKVLSKASVYKRLEKTMQYLEEGLKDSAKQAGINVKFYRAGTMFCTYFTENEVIDAKTAKTSDTEKFKQFFLGMLQKGVYIAPSQFEAGFISLAHSEKDIEKTVQAAYKIFKKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN2_PELRI
Sequence: AVNIPFKVKFRCKAAFC
What is the function of this protein?
Antimicrobial peptide.
What are the official names of this protein?
Ranatuerin-2R.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Ranatuerin subfamily.
Protein: PURA_METST
Sequence: MTCTILVGGQWGDEGKGKCITYFCTQDKPEIIARAGVGPNAGHSVEFNGEKYGLRLTPSGFFNKEARLLIGAGVLVNPEVFEHELEYLSKYAVEGRTFMDANCAIITDKHTKQDKDSAYLSKKIGTTGSGCGPANADRINRTIDYAKDVPELEKYITDVPSEINKAIDEGKDVFIEGSQGFGLSLYYGTYPYVTSKDTCASTAAADVGVGPTKVDEVIVIFKSYITRVGEGPFPTEISPEEAEKMGIEEYGVVTGRKRRVGLFDKDFAKRSCMINGATQIALTCIDRLYPECAKVNKYEDLSQEARDYIEDIEENVGVPITIISTGPDLADTIDLRNEKLN
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOMA_PIG
Sequence: MAAGPRTSALLAFALLCLPWTREVGAFPAMPLSSLFANAVLRAQHLHQLAADTYKEFERAYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF
What is the function of this protein?
Plays an important role in growth control.  Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1.  It stimulates both the differentiation and proliferation of myoblasts.  It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MRAY_PARL1
Sequence: MLYDLLGGMAGDIQALNVFRYITFRTGGATVTALLISFLFGPRIIALLKAKQRRGQPIREDGPQTHIIQKQGTPTMGGFLILVGLVPSVLLWADWSNRYVWIVLFVTLGFGAVGFADDYLKVSKISPKGVPGRVKLFFEFVIALIAMWALVLVSSEPLQTALTVPFFKTLLIELGGFFFLFGALVIVGSSNAVNLTDGLDGLAIVPVMIAAASLGLIVYLVGNAVFADYLQIHFVPGTGELAVFCGALIGAGLGFLWYNAPPAMVFMGDTGSLALGGALGAIAVAAKHELVLAIIGGLFVLEAVSVIVQVASFKLTGKRVFRMAPLHHHFEQKGWAEPTVVVRFWIISVVLAMAGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CAZA2_MACFA
Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLAVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: RECX_PECAS
Sequence: MNKPLRYAMNVLSVRDYSEVEIRRKCAAYLYKSEGTESEADEAIAQATAEDVEAAIAYCKEHGWLDDARYARRYISSRSRKGYGVQRIRMELSQKGIDKTTLTTALNESDIDWCILAKSVVERKFGHPLSDEWKDKVKHQRYLLYRGFFHEEIQSIYTNFSD
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNT_KLEP3
Sequence: MKSIRYGVSLIALFALYYLLPLNFRLLWQPDETRYAEISREMLATGDWVVPHFLGLRYFEKPIAGYWINSIGQWLFGHNNFGVRFGSVFAITMTALLVAWLAWRVFRDKKVAVLSPVIFLTAMLVYAIGTYAVLDPMITLWLALAMCSFWGAAQAQSRSGKILGYALLGVACGMGVMTKGFLALAVPVVGVLPWVIARKRWREVLTYGWLAVIVCTLVVLPWGLAIAQREPDFWRYFFWVEHIQRFAEKDAQHKAPFWYYIPFLIAGSLPWLALLPGALKRGWLERDEARGALYLLGWVAMPFLFFSIAKGKLPTYILPCFAPLSILMARYALEAAKTGAKALRINGMINLGVGLLGLIAVLVVSPWGVMHKPVWTKIELYKCLLAAIAFAVWALMGWLAMKNPGRRWSLAALCPLGLALLVGFAIPDRVIDSKQPQFLVDIVSESLQPSRYVLTNNVGIAGGLAWELKRSDIIMFDKQGELKYGLDWPDAQGSFVSQAGFADWLATHRQQGPVSLVLLMDKGESMVDLPLPKPDNAYELGRVVFLQYLPQ
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MUTL_LACLA
Sequence: MGKIIELNEALANQIAAGEVVERPASVVKELVENSIDAGSSKIIINVEEAGLRLIEVIDNGLGLEKEDVALALRRHATSKIKDSADLFRIRTLGFRGEALPSIASVSQMTIETSTAEEESGTKLVAKGGNIETLEPLAKRVGTKISVANLFYNTPARLKYIKSLQAELSHITDIINRLSLAHPEISFTLVNEGKEFLKTAGNGDLRQVIAAIYGIGTAKKMRQIKGSDLDFELTGYVSLPELTRANRNYITILINGRFIKNFLLNRAILEGYGNRLMVGRFPFAILSIKIDPTLADVNVHPTKQEVRLSKERELMALISKAIDEALSEGVLIPEALENLQGRAKEKESLSVQTELPLQNNPLYYDNVRQDFYVREEATFKINKNQASNDSSEQTFDNFTENQLNTDAVSEKMTDRTVESTTEITDNSLENTVSNFEIDFDNEAKISQSSTFPQLEYLAQLHATYLLCQSKEGLYLVDQHAAQERIKYEYWKDKIGEVSMEQQILLAPYLFTLAKNDFIVLAEKKDLLHEAGVFLEEYGENQFILREHPIWLKETEIEKSINEMIDIILSSKEFSLKKYRHDLAAMVACKSSIKANHPLDAESARALLAELATCKNPYSCAHGRPTIVHFSGDDIQKMFRRIQETHRSKAASWKDFE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: MINC_BURA4
Sequence: MSLKKSPFFELRSGSVDTLLFTVKTTDLDALRTELVKRFEATPEFFADDVVAIDVRRLADGERVELADIRQMLNDVRMRPVGVVALATQGWAGEAGLPLLEARDRRVSAAKPDEAEPAPVVADAVAAATTAEPAPEPAPTQISAGGQTLVIDRPLRSGQQIYAKGDLVVLAPVSHGAEIIAEGNIHIYAPLRGRALAGVHGNHDARIFCTCLEPELISIAGIYRTTENPLPADILGKAVQIRLEEEKLMIEPLRLT
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: PROF5_PHLPR
Sequence: MSWQAYVDEHLMCEIEGHHLASAAILGHDGTVWAQSADFPQFKPEEITGIMKDFDEPGHLAPTGMFVAAAKYMVIQGEPGAVIRGKKGAGGITIKKTGQALVVGIYDEPMTPGQCNMVVERLGDYLVKQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-5, Pollen allergen Phl p 12, pollen profilin variant 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: COX3_NANDA
Sequence: MTHQTHAYHMVNPSPWPLTGALSALLMTSGLIMWFHFNSVALLTLGLTTNMLTMYQWWRDVIRESTFQGHHTPNVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMLQALFITIALGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSSHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RNB_SALTI
Sequence: MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVPWWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSKLDNAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLVYDNVSDWLENNSTWQPENEGIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCAARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGTNTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPAA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP23_SPOER
Sequence: ENFAVGCTPGYQRTADGRCKPTF
What is the function of this protein?
Has excitatory effects on a semi-isolated heart from larval Manduca sexta, causing an inotropic effect at low concentrations of peptide and chronotropic and inotropic effects at high doses.
What are the official names of this protein?
Cardioactive peptide CAP23.
What is the protein family that this protein belongs to?
Belongs to the GBP/PSP1/paralytic peptide family.
Protein: Y1457_HAEIN
Sequence: MKKLLIVTMLFTLALSAQAQWYVQGDLGASKIDITHVNSSNSPSFTQRISVGYAFDKNFRLAVDYTNYGKVTANYADVVDVSLKGKSLGLTGFYDFDLADFKPYVGVRVSTNGADVTANARYYRIEAFATETRIGIGALAGVQYKLTDNVALNTNIEYNRLASNVSDVGVKAGLRFSF
What are the official names of this protein?
Uncharacterized protein HI_1457.
What is the protein family that this protein belongs to?
Belongs to the opacity porin family.
Protein: HGD_MYXXD
Sequence: MSPGSVLKTAPGAYLSGFGNEFATEAVPGALPEGQNSPQRAPFGLYAEQLSGSAFTAPRRENRRSWLYRLRPSANHPAFQPLAQGLLRSGPFDEVPASPNRLRWSPQPPPAQPTDFVDGLVTYAGNGDAASGAGISIHLYAANRSMVDRVFFDADGELLIVPQAGRLRLVTELGVLDVAPGEIAVVPRGVRFRAELPEGQAAGYVCENHGAFFRLPDLGPIGANGLANPRDFLTPVAAFEDVDRPTEVVQKFLGRLWSARYSYSPLDVVAWHGNLVPYKYDLARFNTINTVSFDHPDPSIFTVLTSPSEVPGTANCDFVIFPPRWMVAEHTFRPPWFHRNVMSEFMGLVHGVYDAKAGGFAPGGGSLHNCMSGHGPDRTSYEQAIQADLKPHKIKDTLAFMFESRWVIRPTRFAMETPALQQDYDACWAGFQKAKLP
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: RL29_NOCFA
Sequence: MATGTPAAELRELTEEELVSRLRESKEELFNLRFQMATGQLDNNRRLRVVRHEIARIYTVMRERELGLATGPAGKGDAA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.