PharMolix/UniProtQA huggingface dataset:
Protein: UNG_KLEP3
Sequence: MTTSLTWHDVLADEKQQPYFLNTLKTVAEERQSGITIYPPQKDVFNAFRFTELGDVKVVILGQDPYHGPGQAHGLAFSVRPGVAIPPSLLNMYKELEATIPGFTRPTHGYLESWARQGVLLLNTVLTVRAGQAHSHASLGWETFTDKVIALINEHCEGVVFLLWGSHAQKKGAIIDRQRHCVLKAPHPSPLSAHRGFFGSNHFVQTNQWLADRGEAPIDWMPVLPAESE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_PECAS
Sequence: MKPSIVAKLEALQERHEEVQALLGEPSVIADMDRFRALSREYAQLTDITRCFQQWQQAQEDQQTAEMMLDDPEMRDMAQEELKEGKAAIEALEQELQVLLLPKDPDDERGCFLEVRAGTGGDEAAIFAGDLFRMYSRYAESRRWRVEVMSASDGEHGGYKEVIAKISGDGVYGQLKFESGGHRVQRVPATESQGRIHTSACTVAVMAAVPEAELPDINPSDLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIRAAEIHKRQQEEASTRRNLLGSGDRSDRIRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDALIQPVVQEYQADQLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSD7_AMAEX
Sequence: MSDINATRLPAWLTDCPCVGDDVNRLLTRGESLC
What is the function of this protein?
Probable toxin that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:24050899).
What are the official names of this protein?
MSDIN-like toxin proprotein 7.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: SSRP_SHEB8
Sequence: MVKKNSSKAAPATIARNKRATFEYRFEEKMEAGLSLMGWEVKSIRMGKVNLSDCYVFLKNGEAFMHGCTIIPLNTASTHVVCDPLRLKKLLLSRKELDKLAGLVERQGYSIIPISMYWRKGAWVKVEIGLGKGKKDHDKREDTKAREWEVEKARVMKKEKTHG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: METK_CORA7
Sequence: MTDKAAQAVRLFTSESVTEGHPDKICDAISDAILDALLEEDPDAHVAVETLVTTGQVHVVGEVRTSGYVEIPQIVRKTLVEIGFTSSDVGFDGHTCGVNVAIGEQSQEIGAGVDASTEVRSGTFEDDDQYGAGDQGLMFGYATNETPEFMPLPISTAHHLSRRLTHVRKEGIVPSLRPDGKTQVTFAYDENDVPTRLETIVISTQHDPEVTQEWLAEQLRTHVVEWVVNDADLSQYYTEDTELLINPSGSFILGGPMGDAGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAMRWVAKNIVAAGLADRAEVQVAYAIGRAKPVGLYVETFGTAHEGLSDADIQAAVNKVFDLRPAAIIRELDLQRPIYRQTAAYGHFGRTDVELPWEDTSRADDLRRAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLND_SHIDS
Sequence: MNTLPEQYANTALPTLPGQPQNPCVWPRDELTVGGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVRNSAITGIYSTTLRQLRHARRHLQQPLCNIPQARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSPELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLDLIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: TMCAL_LACH4
Sequence: MSVVGIIAEFNPFHSGHEFLLNQARLIAGNDPIVVVMSGNYVQRGEMAIMSKYQRAKVALQSGADLVFETPFSTAVEPADLFSLGNIEQLAKLGVTDLVFGVENANLNFAYLGSKIAEIPQNHMDFKDYSQTYSTQYNQMVAREVGHEVNQPNAILGLAYAVANHNLGSPLKLHPVNRIGAGHDDLLQRNGVVQSASAIRNLLLHGEDTSNLKYWVPKAEAIELSKQEIYPNWNLLYPFLKYRIESSSIDDLRQIYQMSEGLEYKMKQEIHLSRDFTEFLRRIKSKRYTYSRLRRLSLYTLLNVTQDDMIASFNEESLMLLGFSKTGRQYLKKNRKDFQTEIISKVDKRSAKSGSLALQVRTDRLFEQIMGVDQNFGQRPIEV
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_BACCN
Sequence: MTKYIFVTGGVVSSLGKGITAASLGRLLKNRGLNVTIQKFDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSSVLQKERRGEYLGGTVQVIPHITNEIKERVFRAGRETNADVVITEIGGTVGDIESLPFLEAIRQIKSDIGRDNVMYIHCTLIPYLKAAGEMKTKPTQHSVKELRSLGIQPNIIVVRTEMPVSQDMKDKLALFCDIDPKAVIEAADADTLYAVPLSLQEQNMDQIVCDHLKLDNAPADMTEWKALVDKVRNLSKKTRIALVGKYVELQDAYISVVEALRHAGYTFDTDVEVKWVNAEHVTAENVKELVGDTDGILVPGGFGDRGVEGKIVAIQYARENKVPFLGICLGMQLASIEFARNVLGLEGANSSEINPDTPYAIIDLLPEQKDVEDLGGTLRLGLYPCKLTPETNAYRAYNEPVVYERHRHRYEFNNQFRQEMENAGFIFSGTSPDGRLVEIVELQDHPWFVAAQFHPELVSRPNRPQPLFRDFVQASITNKESK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: BAD_RAT
Sequence: MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIVQQQPGQAANNSHHGGAGTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSASWTRIIQSWWDRNLGKGGSTPSQ
What is the function of this protein?
Promotes cell death.  Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX.  Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity).  Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
What are the official names of this protein?
Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death.
What is the protein family that this protein belongs to?
Belongs to the Bcl-2 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane. Cytoplasm. Note=Colocalizes with HIF3A in the cytoplasm. Upon phosphorylation, locates to the cytoplasm.
Protein: RIR2_VZVO
Sequence: MDQKDCSHFFYRPECPDINNLRALSISNRWLESDFIIEDDYQYLDCLTEDELIFYRFIFTFLSAADDLVNVNLGSLTQLFSQKDIHHYYIEQECIEVVHARVYSQIQLMLFRGDESLRVQYVNVTINNPSIQQKVQWLEEKVRDNPSVAEKYILMILIEGIFFVSSFAAIAYLRNNGLFVVTCQFNDLISRDEAIHTSASCCIYNNYVPEKPAITRIHQLFSEAVEIECAFLKSHAPKTRLVNVDAITQYVKFSADRLLSAINVPKLFNTPPPDSDFPLAFMIADKNTNFFERHSTSYAGTVINDL
What is the function of this protein?
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis.  Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
What are the official names of this protein?
Ribonucleoside-diphosphate reductase small subunit, Ribonucleotide reductase small subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: LPXC_BRUO2
Sequence: MNAYQKTIGRAVTLSGVGVHGGAPASARLLPADADTGILFQRSDIKDSAPVCAHVSQIGATDLCTSLGAREARIDTVEHLMAAISALGIDNLVVEIEGPEVPILDGTSARFIEAVDSVGVVTQDAKRRFIRILKTVRVEAGNSWGEFRPYDGTRFEVEIDFECPLIGRQKFAHDVDEETFRKELSTARTFGFMKDVERLWAAGLALGASLDNSLVIGDDNSIVNADGLRFKDEFVRHKTLDAVGDLALAGLPFIGCFSSYRGGHRLNSEAVKALLSDETAFEIIEA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: VATD_SULIY
Sequence: MSQKVLPTKINLIQFRRQLRLITVIKRLLENKREVLLLYLRTYASEYEKIYNEVNEEMKKVYESYLQAVASEGISNIEEIALSQKPSLEVSSSIKVIFGVKVPTIKLDKSTIPPKPFSDVETSPYLSESYEEMTEALNKIIELVELESTIRSLVSELRKTQRLINSIDNYILPFYRGSIKFIKQILEDRQREEFSRLKIIRRILQRRRESGSG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit D, V-ATPase subunit D.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase D subunit family.
Protein: YR836_MIMIV
Sequence: MNNIDILILFFVLLYVGIAFILKVYINRLNGKNIDKLVLSDNIKIVIFVPETHVDIIIEALGKAGAGCIGCYDYCSFATKGIGRYRSLEGSSPTIGNINEFTSCEEIKIETICPRNKVAQIIRITQKVRPYETMGYDLYPMLNLSNNF
What are the official names of this protein?
Uncharacterized protein R836.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: COS_DROPS
Sequence: MEIPIQVAVRICPYTEPSENRKPVAGAEADASAFGNAEAKAESFSDSEDNKNDASNRQRPEESTDANGNSEGGRQLKKETLPTDSNGNENGTIVPLGSGCCVQAIPISASALGLPSALPGGRAQDSIAAGLIQVGAHTVPVTHALGSGTTQSQLYYQTVFPLISLFLEGFDASVVTYGQRGQGKTYTLYGPGFECVYGEADQGVVQRCVRDIFAHIAGHSERTYAVNVGFVEICEGEVCDLLDMGNVHCQSVEEVFRWLQIGLATRQPKSAHSLFTLTLEQQWVSKEGLIQHRLSTASFSDLCATERWGEPPPGNPRDAGLQMLELVVNTLTDPSIMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCVSPQEQHVAETLGNLQFAFKVQCVRNYVIMNTYSDDNTPISPETMPNGSSNPGAGPLAQVAAGDNFGLQFAASQWFKLVSNAEGLFAKLMASNLISELEKEQIEEWLFLKQECEECLSSTEAMRSQKQLVPIQEAEEPEESVSEPPNSDNDTDNESQRPDLADKLESLMEEFRAKTDALIQSKHAEFLTKHPKAVMQSQERDKESKLDAPPEKDKEKIEERKTSIAGRRRSIQPGASLSTAELALLNRVALQQPTAQPPPSVLDPESSIDPLESSAGEGLRQAAIAAAAANAPIEQLQKKLRKLHAEIEGRQRQLKEIEQTMQVKQNIISELVKNSDTRSHAKQRFQKKKAKLEAECDKAKKHLAKALIQGREKGETERWSAIIAHIEHRLEDLSSMKHIAGESGQKLKKLQQSMAESRKQQEELEKKIRKESKLRDQLETELAKLKESRDGASGGKELVKLDSPEQQGRQLKAVQARITHLNHILREKSDNLEECAGGEGPAPAQQESLRHEIRNLRGTRDLLLDERCHLDRKLKRDKMLTQREERKLLECDEAIEAIDAAIEFKNELICGHKSIDTSDRLQREKGEQMLMARLNKLSPEEMRTLLYKYFNKVIDLRDSSRKLELQLVQLERERDAWEWKERVLSNAVRQARLEGERNAVLLQRQHEMKLTLMLRHLAEETSASSASYGERALAPGHQTSSGDFDYELDFYKAAATTTTTTNHKALVKPPKSTPSGAALEKYKDKEQRGAGRNIFAKFQVLTRYASSAASAAAAGSCSSTVDESTALIESTTTATATTTTTTTTTTTGGKGKERGLPNIRQDQLKRLMPAPTVTKVTRQKNKIIIQDASRRN
What is the function of this protein?
Regulates cubitus interruptus (ci) processing by recruiting multiple kinases to promote its efficient phosphorylation.  Scaffolds multiple kinases and ci into proximity to promote its hyperphosphorylation, which then targets it for SCFSlimb/proteasome-mediated processing to generate its repressor form.  Hh signaling inhibits ci phosphorylation by interfering with the cos-ci-kinases complex formation (By similarity).
What are the official names of this protein?
Kinesin-like protein costa, Kinesin-like protein costal2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y2912_SORC5
Sequence: MTRSAPAASATSRTAIGSAGAPAADARRALGARAEDAVVAHLAAQGVEIVARNARVGRLEIDVVARDGPVIAIIEVRTRGAGSYVRALDSIDARKRARVRRAGERLWRATFSRVRGVERMRFDAASVTFLPSGEATVEIIKAAF
What are the official names of this protein?
UPF0102 protein sce2912.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: UL24_HHV6Z
Sequence: MSLTGLPDIRKKIGQFHHLRIYKQILSLQGNFARLNYFLGDVFPANLRSASVSVFFEVRLGPRIPDCIVLLKSVDAKDEFAFHCYFFEFKTTLGKSTMQSVHHNCIHQAQYLQGLRQLHQSISFLDQYLIADEVLWNVVPVICFFRQWGLKLDFFKKFSGKTKRLSFSFICDLFARSQDGAVQSLLSIPNYTNFRRACQKHTDLYRRRYQKASKSVLTKTSGENRSRASRQVAKNAPKNRIRRTAKKDAKRQ
What is the function of this protein?
May participate in nuclear egress of viral particles.  Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1.  Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli (By similarity).
What are the official names of this protein?
Protein UL24 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL24 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus, host nucleolus. Host Golgi apparatus.
Protein: COBT_ROSCS
Sequence: MSLLTDTITRIGSLDSAAATAAQARQDVLTKPQGALGRLETLSVQIAGITGQTRPRLNNPAVIVMAADHGVARRGVSAYPSEVTSQMVLNFLNGGAAINVLARHIGARVIVVDIGVAANLPSHSELIDRKLGMGTADFSVEPAMSRAQAQQAVEIGIACAYDAIASGVDLLATGDMGIGNTTASSAVVAAITGRPVAEVTGRGAGIDDAGLARKIAVIEQALALHHPDPRDALDVLTKVGGFEIGGLAGVILGAAARRVPVVIDGFISGAAALIACTLAPSAQPFLIAALRSVERGHDAVFAHLDLTPLFDLGMRLGEGTGAVLGMSLCQAACKILDEMATFGEAGVSGKVEG
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: ENO_BORAP
Sequence: MGFHIYEIKARQIIDSRGNPTVEADVILEDGTCGRSAVPSGASTGINEAVELRDGDKSVYMGKGVLKAIENIKNIIAPELEGMSALNQVAIDRKMLELDGTPTKEKLGANAILAVSMATAKAAAKYLGLKVYQYLGAYKANILPTPMCNIINGGAHSDNSVDFQEFMIMPIGAKTFSEAIRMSVEVFHTLKGILHGKGYATSVGDEGGFAPNLKSNEEACEMIIEAIKKAGYEPGKDIAIALDPATSELYDPKTKKYVLKWSTKEELTSEQMVEYWSKWVEKYPIISIEDGMAEEDWDGWKKLTDKIGHKIQLVGDDLFVTNTSFLKKGIEMGVANSILIKVNQIGTLTETFEAVEMAKKAGYTAIVSHRSGETEDTTIADLVVALGTGQIKTGSLSRTDRIAKYNQLIRIEEELETTAEYHGKNVFYSIKQK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DCDB_HALSA
Sequence: MILSDQDILARLADGDLAIEPLEDVDLQVQPASVDVRLGRRFLEFERANVPCIHPNREDEVDEYVTETVVEDGDEFILHPGDFVLGTTKERVEVPRDLVAQVEGRSSLGRLAVVVHATAGFIDPGFNGRVTLELSNLGKVPVALTPEMRISQLVFTELTSPADRPYGDERGSKYQDQDGPQASRIRGDREFGGTQ
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RNJ1_BACSU
Sequence: MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPEDELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIGLLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIVHTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDIFRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPKNTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPIPGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGEYRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDIGNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELISNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV
What is the function of this protein?
An RNase that has endonuclease and 5'-3' exonuclease activity, playing a role in both rRNA and mRNA stability and degradation.  Endonuclease activity can cleave within 4 nucleotides of the 5'-end of a triphosphorylated RNA.  Endonuclease digestion by the RNase J1/J2 complex occurs at a different site and in some cases more efficiently than J1 or J2 alone.  The exonuclease activity of the J1/J2 complex is highly processive on substrates longer than 5 nucleotides, on shorter substrates is distributive.  Preferentially cleaves ssRNA, possibly in AU-rich regions.  The 5'-exonuclease activity acts on 5'-hydroxyl and 5'-monophosphate but not 5'-triphosphate ends; it can digest through stem-loop structures if they are not too stable.  Required for maturation of 16S rRNA.  Acts preferentially on 16S rRNA precursors after association of the 30S and 50S ribosomal subunits.  Plays a role in the secondary pathway of 23S rRNA 5' end maturation.  Probably also participates in processing of pre-scRNA (the precursor of the signal recognition particle RNA).  Major RNase that degrades both RNAs of the type I toxin-antitoxin system BsrE/SR5 (PubMed:26940229).
What are the official names of this protein?
Ribonuclease J1, RNase J1.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Colocalizes with ribosomes.
Protein: DAPF_XANCB
Sequence: MSADVHTGRLRFTKMHGAGNDFVVLDLRNGTPPPDASLAARLADRHFGVGCDQILTIETPRSAEAVAAYRIWNSDGSHSQQCGNGARCVAAWLVREGTAQGDVFTIDSPFTAHRVERLDAGTYSVAMGVPQFEPTQIPLAGFAHARDEYALPVHGETVRFGAVSMGNPHAVVEVGRVDAAPVERVGALLQQNAAFPESVNVGFAQVVDPAHVRLRVYERGVGETLACGSGACAAAVVLMHRGRVERDVRVSLPGGELRIRWAGEQAQVVMSGPAVFVFDGEWNQ
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VM3_BOTMO
Sequence: LGPDIVSPPVCGNELLEVGEECDCGTPENCQNE
What is the function of this protein?
Metalloproteinase moojenin: snake venom metalloproteinase that cleaves both alpha- and beta-chains of fibrinogen, but not the gamma-chain.  Shows a coagulant activity on bovine plasma about 3. 1 fold lower than crude venom.  Renders the blood incoagulable when intraperitoneally administered into mice.  Induces necrosis in liver and muscle, but does not cause histological alterations in mouse lungs, kidney or heart.
What are the official names of this protein?
Zinc metalloproteinase-disintegrin-like moojenin, Snake venom metalloproteinase, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIb sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YOBD_ECO5E
Sequence: MTITDLVLILFIAALLAFAIYDQFIMPRRNGPTLLAIPLLRRGRIDSVIFVGLIVILIYNNVTNHGALITTWLLSALALMGFYIFWIRVPKIIFKQKGFFFANVWIEYSRIKAMNLSEDGVLVMQLEQRRLLIRVRNIDDLERIYKLLVSTQ
What are the official names of this protein?
UPF0266 membrane protein YobD.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PP1_BRANA
Sequence: GDIHGQYQDLLRLFEYGGYPPSANFLFLGDYVDRGKQSLETICLLLAYKIRYPSKIYLLRGNHEDAKINRIYGFYDECKRRFNVRLWKIFTDCFNCLPVAALIDDKILCMHGGLSPELDNLNQIREIQRPTEIPDSGLLCDLLWSDPDQKIEGWADSDRGISCTFGADKVAEFLDKNDLDLICRGHQVVEDGYEFFAKRRLVTIFSAPNYGGEFDNAGALLSVDESLVCSFEIMKPALASSSGHPLKKVPKMGKS
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
Protein: COAD_POLAQ
Sequence: MTVAVYPGTFDPFTRGHEDLVRRASSIFSELIVGVADSRSKRPFFGLQERIDIAKEVLGHYHNVKVVGFSGLLKDFAREHNARVIVRGLRAVSDFEYEFQMAGMNRYLLPDVETLFLTPSDQYQFISGTFVREIASMGGDVSKFVFPSVEKWLVQKIASGTQHSE
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.