PharMolix/UniProtQA huggingface dataset:
Protein: DJC27_BOVIN
Sequence: MEASMPKRKEPGKSLRIKVISMGNAEVGKSCIIKRYCEKRFVSKYLATIGIDYGVTKVQVRDREIKVNIFDMAGDPFFYEVRNEFYKDTQGVILVYDVGQKDSFDALDTWLAEMKQDLGPHGNMENIVFAVCANKIDCTKHRCVDESEGRLWAESKGFLYFETSAQTGEGINEMFQTFYLSIVDLCENGGKRPNTNSSASFTKEQADTIRRIRSSKDSWDMLGVKPGASRDEVNKAYRKLAVLLHPDKCVAPGSEDAFKAVVNARTALLKNIK
What is the function of this protein?
GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed.  May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
What are the official names of this protein?
DnaJ homolog subfamily C member 27, Rab and DnaJ domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECO_VIBPA
Sequence: MSNLSAEGFQRCFVLHRRPYSESSLILDVFSEEYGRITLMAKGARSKRSNLKGALQPFTPLLLKWSGKGSMKTLRQAEPISLGLPLFGINLYSAMYVNELVGRVLMAEVPMPALFHDYLHALTELAQCENPEPALRRFELALLSSMGYGVDFLHCAGTGEPVDPEMTYRYREQKGFIASVRRDNLTFLGNELIAISERRFVTKEQLKAAKRFTRIALKPYLGGKPLKSRELFIQTPRARSNGK
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: HIS7_DESVH
Sequence: MQTVARKASVERVTNETTIALTLTIEGEGNVRVTTGFGMLDHMLTLTAFWAGFDLDLTCKGDMHIDAHHTAEDVALCLGQALATALDDRKGIARVGFARVPMDEALAEVTLDISGRPWLEWRGDEYLPPVIAGEEKDLWREFHKAFASAARMNLHVSYLYGKNGHHLLESASKGLGLALRQAVRRDRQTVLSTKGSLD
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAAY1_SCHCO
Sequence: MTDRLASLRAISASAKSMMSIAAARGAQPTAPIQTAPVHFDPLPTPYLDGIRARLTEVKLPPKALKSALNSYDQACARWRYSLDESFSQAARSVSPHNLHLLSTLRFRLYTEQVERWAVQVLQVAEQWRAEMEKQRAHIAASTDKSKKPRPKFHSEYTPLLELYFRFNAYPTYADRRVLAEKTGMLTRQITVWFQNHRRRAKGPLPRMTPTAKIPLEEFERERENLARKLLPMLLPPHLRPITLGNNKTPDLTTSSRARALPPAKEDKPPQVTRKTSKKVPKTAHPAPSTLVAPSQDTVMADAISTKKTKKAKSKQCADIEMKDSSKPKRRKMKKLPKGVVGTADVAMCIDPPQVPKKNKVKPKKSMAFDSQAELAFAQAAYPSPSKYAWVHTRKPQTDAPKAKASSVTSDVARLGKGRPGKPSPPASSTVPSRRVSTRLNAMRPPYAFPARYDSAAVPMTFAVAQVTKFTFATDSASFGFKPRISTRRPNITSDAMSQLVSSFERLRLLSVELSVSRNPPLPAFEHQRLVDLRVEGLTSGEVTALHFTPGAYAARLAVTYIPPRAPLPSTVLDLPRALRARLVHPMVLPETVTQPDAFAPFIALAERRARRKARKEKKRQEEKQAKKDKKERKKAGLPHRAPSTVDAPDVSSRASSLDSDVSTSARKSSKKSKRQPSSSSRASSVASSGRTPSLSSTSSRRSSGMSMPSTPGPEQSLPIVAASDFALGGEEDVSMDADLMAQLFGSDENADAVGYDLPMHPEPFTADMITFTSCADGALGDMTADVNMPNLGQSSIDDMNWTASVGSNAQDPASQESGGDEASHWLDISFDRPTTTSQINVLGGTYSCELGGSDNMNAPLDFSDLTFGLDTGADYFSGFNNTIGGTTIMV
What is the function of this protein?
Specifies A-alpha-1 mating-type.  May regulate the expression of genes specific to the homokaryotic cell type.
What are the official names of this protein?
Mating-type protein A-alpha Y1.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFC2_HUMAN
Sequence: MNSPCDRLQQFIQVLLEESWSFPSFANTLHWPENLLSYIDELVWQGSLQNFHQHEVRFDKPPLRLPLTGFSSLTENWSSRQAVSSRLVATAASPPAGCQAPIAFLGLKFSSLGPARKNPALCFLYDQSNSKCNTSWVKENVGCPWHWCNIHEALIRTEKGSDPMFYVNTSTGGRDGFNGFNLQISDPWDPRWASGVDGGLYEHKTFMYPVAKIRIARTLKTTVTGLSDLASSIQSAEKELTSQLQPAADQAKSSRFSWLTLISEGAQLLQSTGVQNLSHCFLCAALRRPPLVAVPLPTPFNYTINSSTPIPPVPKGQVPLFSDPIRHKFPFCYSTPNASWCNQTRMLTSTPAPPRGYFWCNSTLTKVLNSTGNHTLCLPISLIPGLTLYSQDELSHLLAWTEPRPQNKSKWAIFLPLVLGISLASSLVASGLGKGALTHSIQTSQDLSTHLQLAIEASAESLDSLQRQITTVAQVAAQNRQALDLLMAEKGRTCLFLQEECCYYLNESGVVENSLQTLKKKKSSKRS
What is the function of this protein?
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection.  Endogenous envelope proteins may have kept, lost or modified their original function during evolution.  This endogenous envelope protein has lost its original fusogenic properties.
What are the official names of this protein?
Endogenous retrovirus group FC1 member 1 Env polyprotein, Envelope polyprotein, Fc2deltaenv, HERV-F(c)2_7q36.2 provirus ancestral Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the gamma type-C retroviral envelope protein family. HERV class-I F(c)2 env subfamily.
What are the subcellular locations of this protein?
Virion.
Protein: POTA_SHIDS
Sequence: MGQSKKLNKQPSSLSPLVQLAGIRKCFDGKEVISQLDLTINNGEFLTLLGPSGCGKTTVLRLIAGLETVDSGRIMLDNEDITHVPAENRYVNTVFQSYALFPHMTVFENVAFGLRMQKTPAAEITPRVMEALRMVQLETFAQRKPHQLSGGQQQRVAIARAVVNKPRLLLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGRIEQDGTPREIYEEPKNLFVAGFIGEINMFNATVIERLDEQRVRANVEGRECNIYVNFAVEPGQKLHVLLRPEDLRVEEINDDNHAEGLIGYVRERNYKGMTLESVVELENGKMVMVSEFFNEDDPDFDHSLDQKMAINWVESWEVVLADEEHK
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CAP_BURTA
Sequence: MVRLLAKLLRSTIHGSNGVSLDAVSSTHGTPGFQTPDARVISRFGFN
What is the function of this protein?
Peptide antibiotic that functions through inhibition of the bacterial DNA-dependent RNA polymerase (RNAP) (PubMed:21396375, PubMed:30626643).  Inhibits transcription by binding in RNAP secondary channel, where it sterically blocks the folding of the trigger loop, which is essential for efficient catalysis (PubMed:21396375, PubMed:30626643).  In contrast to MccJ25, does not restrict access of nucleotide substrates to the catalytic center and shows a non-competitive mode of inhibition (PubMed:30626643).  Shows activity against closely related Gram-negative Burkholderia and Pseudomonas strains (PubMed:18671394).  Is not active against Gram-positive bacteria (PubMed:18671394).
What are the official names of this protein?
Capistruin, Cap, Class II lasso peptide, Lariat peptide, Ribosomally synthesized and post-translationally modified peptide, RiPP.
What are the subcellular locations of this protein?
Secreted.
Protein: PGK2_METJA
Sequence: MDLQNDIIVRGKSYEMPFSKGILARSLTAAGLKPSIAYRIAWDIYEMLKKENIRVIDKADLRRRVYYYLISKNYDEVAKKYLLWRMVLGRRPIVILIGGASGVGTSTIAFEIASRLGIPSVIGTDSIREVMRKVISRDLIPTLYESSYTAWKVLRDDEGNKYIKGFERHSEAVLTGVEGVIDRCLVEGQSVIIEGTHLVPTLLKDKYLENSHVVFIMLTIYNEELHKMRFYARGRVSSRPTERYLKYFKIIRMINDYMVETAKKKGIPVVENIKISETVDKCLNIITERLKTMIELEGLSEEDMLEEGL
What is the function of this protein?
Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate.  Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.
What are the official names of this protein?
2-phosphoglycerate kinase, 2PGK.
What is the protein family that this protein belongs to?
Belongs to the 2-phosphoglycerate kinase family.
Protein: ALS2_CANAL
Sequence: MLLQFLLLSLCVSVATAKVITGVFNSFDSLTWTRAGNYAYKGPNRPTWNAVLGWSLDGTSANPGDTFTLNMPCVFKFITDQTSVDLTADGVKYATCQFYSGEEFTTFSSLKCTVSNTLTSSIKALGTVTLPISFNVGGTGSLVDLESSKCFKAGTNTVTFNDGDKKISIDVDFEKTNEDASGYFIASRLIPSINKASITYVAPQCANGYTSGAMGFTIGSGDTTIDCSNVHVGITKGLNDWNFPVSSDSLSYNKTCSSTGISITYENVPAGYRPFFDVYTSVSDQNRQLKYTNDYACVGSSLQSKPFNLRLRGYNNSEANSNGFVIVATTRTVTDSTTAVTTLPFNPSVDKTKTIEILQPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDVPYHTTTTVTSEWTGTITTTTTRTNPTDSIDTVVVQVPSPNPTVTTTEYWSQSYATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSYATSSTVTAPPGGTDTVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSFATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYVTTSTITAPPGGTDTVIIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNPTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNPTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNPTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPSPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNPTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPSPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNPTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPSPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPNPTVTTTEYWSQSFATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSFATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTITAPPGDTDTVIIREPPNYTVTTTEYWSQSFATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTITAPPGDTDTVIIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTGPPGSTDTVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPSPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSESYATTTTVTGPPGGTDVILIREPPNPTVTTTEYWSESYATTTTITAPPGATDSVRIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTAPPGGTDTVIIREPPSPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPSPTVTTTEYWSQSYATTTTVTAPPGGTATVIIREPPNYTVTTTEYWSQSYATTTTVTGPPGGTDTVIIREPPNPTVTTTEYWSQSYATTLTITAPPGGTNSVIIRVHSSTNDESSESTFSTLSVPSFSGSISVVSTVSRPHYVNSTVTHLPSSSSKPVDIPSSDVVTSTNDNSLTSLTGSENGKTSVAISTTFCDDENGCQTSIPQGSVVRTTATTTATTTTIIGDNNGSGKSKSGELSSTGSVTTNTATPDVPSTKVPSNPGAPGTGVPPPLAPSTETQTTNNVPGSPNIPATGTTDIIRESTTVSHTVTGNGNTGVPMNPNPVLTTSTSLTGATNSATNPSHETSVNTGSGGSTNIVTPPSSATATVVIPGTDNGATTKGQDTAGGNSNGSTATTNIQGGNNEPGNQPGTNTTGEPVGTTDTQSVESISQPTTLSQQTTSSLISTPLASTFDGSGSIVQHSGWLYVLLTAISIFF
What is the function of this protein?
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation.  Plays an important role in the pathogenesis of C. albicans infections.
What are the official names of this protein?
Agglutinin-like protein 2, Adhesin 2.
What is the protein family that this protein belongs to?
Belongs to the ALS family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer.
Protein: CYSZ_PASMU
Sequence: MLSHAELKQGFHYFMMGWHLITQKGLRRFVIMPILLNIVLLSGLFWLFITQIEKMIGMLMLSIPDWLSWLSSILLIFAILMILVLFYFVFTTLSGFIAAPFNGLLAEKVEKMLTGENLVEGSVWDFMKDIPRMLGREWQKLVYSLPKLIILFLLGFVPVLGQSVIPIIVTLFTAWMMAIQYCDYPFDNHKVPFFVMKAELAEKRALSLSFGGLVMLCTFIPLVNLVVIPVAVCGATAMWVTHFRDHLAMKPLNQEGVSRVSTVSIVK
What is the function of this protein?
High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake.  Provides the sulfur source for the cysteine synthesis pathway.
What are the official names of this protein?
Sulfate transporter CysZ.
What is the protein family that this protein belongs to?
Belongs to the CysZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FAL1_USTMA
Sequence: MSGGINAGDSKLAFESSEHVKVATTFDAMGLKEDLLRGIYAYNFEKPSAIQQRAILPIIRGRDVIAQAQSGTGKTATFSISMLQSIDTTLRETQALVLSPTRELAIQIQSVVLALGDYLNVQCHACIGGTSVGEDIRKLDYGQHIVSGTPGRVYDMIRRRHLRTKNIKMLILDESDELLNMGFKDQIYDVYRYLPPSTQVVLLSATLPQDVLEMTSKFMTDPVRILVKRDELTLEGIKQFFVAVEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLSAKMKENNFQVSSMHGEMQQKERDEVMAEFRQGSSRVLITTDVWARGIDIANISLVINYDLPTNRENYIHRIGRSGRFGRKGVAINFVTVDDVRTLRDIEQFYSTQIDEMPVKLEDML
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase FAL1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ATPB_HELHP
Sequence: MQGKITQVMGPVVDVEFSSYLPMINEAIDVNFDIEGRKNNLVLEVAAHLGDNRVRTIAMDMTEGLIRGQEVKARGKPIEVPVGEAVLGRIFNVTGDVIDGGKPLESDLKWPIHREAPSFENQSTRTEMFETGIKVVDLIAPYSKGGKVGLFGGAGVGKTVVIMELIHNVAYKHSGYSVFAGVGERTREGNDLYHEMKEGGVLDKVALCYGQMNEPPGARNRIAFTGLTMAEYFRDEKGLDVLMFIDNIFRYAQSGSEMSALLGRIPSAVGYQPTLAGEMGKLQERITSTKKGSITSVQAVYVPADDLTDPAPASVFAHLDATTVLDRKISEKGIYPAVDPLGSTSRILDPQIVGEEHHKVATGVQQVLQKYKDLQDIIAILGMDELSEEDKQVVARARKIERFLSQPFFVAEIFTGSPGKYVTLEETLEGFKGILEGKYDDIPENAFYLVGNIQEALEKAQKLKNA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UBID_SALAR
Sequence: MKYHDLRDFLTLLEQQGELKRITLPVDPHLEITEIADRTLRAGGPALLFENPKGYSMPVLCNLFGTPKRVAMGMGQDDVSALRDVGKLLAFLKEPEPPKGFRDLFDKLPQFKQVLNMPTKRLRGAPCQQKIASGDDVDLTRLPIMTCWPDDAAPLITWGLTVTRGPHKERQNLGIYRQQLIDKNKLIMRWLSHRGGALDFQEWLAAHPGERFPISVALGADPATILGAVTPVPDTLSEYAFAGLLRGTKTEVVKCLSNDLEVPASAEIILEGYIEPGEMAPEGPYGDHTGYYNEVDNFPVFTVTHITQREDAIYHSTYTGRPPDEPAVLGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRLAVVTMKKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDVNARDWNDVIWAITTRMDPARDTVLVDNTPIDYLDFASPVSGLGSKMGLDATNKWPGETQREWGRPIVKDPEVTARIDAIWDELAIFK
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: YE084_YEAST
Sequence: MYLYVSFLINSLLLSYQSCSSFQINRFESYRNHLEFVLITWPPTMHLYISYFFPLCAISLGKICNQGKHPLVPFQFLCYFKNHPFIIYLYFFRPGLYQFIFRTFHISSNSAAHIFFHHDTGNRMGPWILAKQSLYSPVQNPQDICFPQQLQLQLINPMRKCRVYVIQDAF
What are the official names of this protein?
Putative uncharacterized membrane protein YER084W-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GBP3_MOUSE
Sequence: MEAPICLVENWKNQLTVNLEAIRILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFSLGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINQQALEQLHFVTELTQLIRAKSSPREDKVKDSSEFVGFFPDFIWAVRDFALELKLNGRPITEDEYLENALKLIQGDNLKVQQSNMTRECIRYFFPVRKCFVFDRPTSDKRLLLQIENVPENQLERNFQVESEKFCSYIFTNGKTKTLRGGVIVTGNRLGTLVQTYVNAINSGTVPCLENAVTTLAQRENSIAVQKAADHYSEQMAQRMRLPTDTLQELLTVHAACEKEAIAVFMEHSFKDDEQEFQKKLVVTIEERKEEFIRQNEAASIRHCQAELERLSESLRKSISCGAFSVPGGHSLYLEARKKIELGYQQVLRKGVKAKEVLKSFLQSQAIMEDSILQSDKALTDGERAIAAERTKKEVAEKELELLRQRQKEQEQVMEAQERSFRENIAKLQEKMESEKEMLLREQEKMLEHKLKVQEELLIEGFREKSDMLKNEISHLREEMERTRRKPSLFGQILDTIGNAFIMILPGAGKLFGVGLKFLGSLSS
What is the function of this protein?
Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:24739961, PubMed:24715728).  Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (PubMed:9659399).  Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24739961, PubMed:24715728).  Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24739961, PubMed:24715728).  Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24739961, PubMed:24715728).  May play a role in erythroid differentiation (PubMed:9659399).
What are the official names of this protein?
Guanylate-binding protein 3, GTP-binding protein 3, GBP-3, Guanine nucleotide-binding protein 3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
Protein: GATB_STRP8
Sequence: MNFETIIGLEVHVELNTNSKIFSPSSAHFGEDPNANTNVIDWSFPGVLPVMNKGVIDAGIKAALALNMDIHKEMHFDRKNYFYPDNPKAYQISQFDEPIGYNGWIEIKLEDGSTKKIRIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMRSPEEAYAYLTALKEIIQYTGISDVKMEEGSMRVDANISLRPYGQEQFGTKTELKNLNSFSNVRKGLEFEVERQAKLLRSGGVIRQETRRYDEANKGTILMRVKEGAADYRYFPEPDLPLYEIDDAWIDEMRAQLPQFPAQRRAKYEEELGLSAYDASQLTATKVLSDFFETAVSLGGDAKQVSNWLQGEIAQFLNAEGKTIEEIALTPENLVEMIAIIADGTISSKMAKKVFVHLAKNGGSARAYVEKAGLVQISDPAVLVPIIHQVFADNEAAVADFKSGKRNADKAFTGFLMKATKGQANPQVAQQLLAQELQKLRD
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: PMEA_ASPFU
Sequence: MYLPSLVLGLLGFGLTASTSPIEERSNRSKAPAGCLTVGSSGTYATIGAALSALGSSTSDACIFIGAGTYQEQITIDYKGKLTMYGETTDTSSYKQNLVTITHSISSPEAGSLDKSATVNVRSDGFKMYNINVINGYGKGAQAVTLVANADKLGFYGCSFVGYQDTLYAKAGRQYYSNCYIEGAVDYIFGDASAWFGECDLVSVGPGYITAMSRTTADETTWYAIDHCNIYGKPGVDLTSAVYLGRPWRVLARVIFQNSQLSNIINPKGWSPMATGATPLYYEYNNKGAGADTSKREYESPISGAVSIATVLGGGWNSWVDTTY
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.
What are the official names of this protein?
Probable pectinesterase A, Pectin methylesterase A.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted.
Protein: MED31_KLULA
Sequence: MSQQASTELTIEEGELPTRFEIELEFVQSLANIPYVTYLLTQLQLWQDPKFKRYLKYLEYWHEPEYAQCIVYPNSLFVLKLLNTLFEGSTVNENGVLEGCEHVPRILQTQGTQWMNEMVERWRE
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 31, Mediator complex subunit 31.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 31 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YCF4_GRATL
Sequence: MYTMAQIKTDKILGSRRISNYFWATIILLGGLSFFLVGLSSYLKIELLPFTKSTDLLFLPQGIIMTFYGTAAILISLFLWLTIIWNIGSGYNEFNRDIGLVTIYRLGFPGKNRLIKLRYKIHDIYSIKVQIQEGLTPKREIYLKTKDKREIPLTQVGQPMSLAQIEERAAFLAKFLGVILEGIR
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PYRE_BRUA4
Sequence: MNTEDVLAVFREAGAILEGHFILTSGLRSPVFLQKARVFMHADKTEKLCKALAEKIQAADLGPIDYVVGPAIGGLIPSYETSRHLRVPSVWVERENGVFRLRRFDVPKGARVVIVEDIVTTGLSIRETIDCMKDLGIEVVAAACIVDRSAGKADVGTKLIALAEYEVPAYPADKLPPELAAIPAVKPGSRNI
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: ARL4D_BOVIN
Sequence: MGNHLTEMAPTTSFLPHFQALHVVVIGLDSAGKTSLLYRLKFKEFVQSIPTKGFNTEKIRVPLGGSRGITFQVWDVGGQEKLRPLWRSYTRRTDGLVFVVDAAEAERLEEAKVELHRISRASDNQGVPVLVLANKQDQPGALSAAEVEKRLAVRELATATLTHVQGCSAVDGLGLQPGLERLYEMILKRKKAARAGKKRR
What is the function of this protein?
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).  GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.  Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 4D.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Cell membrane. Nucleus. Cytoplasm.
Protein: SYFA_ACIF2
Sequence: MSFQSMASIAEAAREVAAASDLNTLEQIRLRWLGRKGVLTEAMQQLGQLSPETRREAGQLLNERKSEIQSLLQERKAELEAAAIHARLQQERLDVTLPGRREACGSAHPIRQTLEWIEHYFFGLGFETSDGPEIEDDYHNFAALNIPEDHPARAMHDTFYLDATRLLRTQTSTVQIRFLESHQPPLRMIATGRVYRRDSDITHTPMFHQVEGLLLDERASFADLRGLLSDFLHGFFAKPDLPVRFRPSYFPFTEPSAEIDIGCVICGGSGCRVCKQTGWLEVLGCGMVHPAVLAGAGVDGERFSGFAFGMGVERLTMLRYGVNDLRLFFENDLRFLKQFS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICP2_ENTH1
Sequence: MKQFIFFALLCTSTYAAIHILTEKEDHATLHISFNDLIKIQLRTNPSTGYAWNIEYPTDTFSLSQDTIKAEPHPSGMVGFPSIREIQLKPLKVGTTTIKLGYSRPWEKGKEPLRSLTYSVVIR
What is the function of this protein?
Cysteine protease inhibitor (PubMed:16802137, PubMed:16979632, PubMed:21440496, PubMed:32731033, PubMed:20951777).  Inhibits cysteine proteases CP1, CP2 and to a lesser extent CP5 (PubMed:16979632).
What are the official names of this protein?
Amoebiasin-2, Cysteine protease inhibitor 2, EhICP2, ICP-2.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I42 family.
Protein: Y2479_STAAN
Sequence: MTNFTFDGAHSSLEFQIKHLMVSKVKGSFDQFDVAVEGDINDFSTLKATATIIPSSINTKNEARDNHLKSGDFFGTDEFDKITFETKSVTENKVVGDLTIKGITNEETFDVEFNGVSKNPMDGSQVTGVIVTGTINRENYGINFNQALETGGVMLGKDVKFEASAEFSISE
What are the official names of this protein?
UPF0312 protein SA2479.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family.
Protein: ISPG_ACTP2
Sequence: MSIHQSPIKRRESKKIWVGNVAVGGDAPISVQSMTNTRTTDVEATVAQIKSLERVGADIVRVSVPTMDAAEAFKVIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRAVVDCAKDKNIPIRIGVNAGSLERDLQEKYGEPTPQALLESALRHVDILDRFNFENFKVSVKASDVFLAVESYRLLAKQIVQPLHLGITEAGGARAGSVKSAVGLGLLLSEGIGDTLRISLAADPVEEVKVGFDILKSLRIRSRGINFIACPTCSRQEIDVIATVNALEQRLEDILTPMDVSIIGCVVNGPGEALISDLGVTGSNKMSGFYLDGVRQKERFDNEKLIDQLEAKIRARVAEQHNRIQIEQI
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.