Protein: BEA1_GIBF5
Sequence: MTSLNTKSGTPVVPLLLRSDDASHTDTLVEEVSCSLGLGRDRIENILPSTAFQQDVIDCAGSEKQRSIGHVAYEISNDIDISKLAAAWKDTINRTPALRTCAFTSSSGETYQVILKDSFVFSWMFSTSADQKDAVVKDEAAAAASGPRCNRFVLLDDPIQKKILIWTFSHALVDTSFQERILGRVLKAYTHGHDELSNRPYTPESSDPEDDGLSLTPTDGSKTPETEGLHPATQYWKNYLSDLNASAFPHLTSPLAVPYPNAKSEHRITFTASSSSTWPSVAVCRTALAILLSRYTHSQEALFGVVTEQQQLLVNGPTRTVVPFRVHCASDQSLSDIIDVVNANDDAIRQFADVGLRSISSTGDDGVAASGFQTVLLVTEGDNEQSSSTFEILQKTEESELFMPCTNRALLLHCQIASDGLSIIARYDKSLIHSQQIARLLRQLGQLIQRLRGSPDKLPSAGELDISTSEDQAEIQSWNSHPIPSQPTLIHKEMLKTASLSPSKVAICAWNGEWTYSELDNITSRLAALIKFSTPDQEHAILPIYFEKSKWVVASMLAVIKAGHAFALIDPNDPPARVSQVVGQTGATVALTSKLYRSKVQGIIERCIIVDDDLVQSLICTCALKPDPTLAKVTPEDLAYVIFTSGSTGDPKGIMIEHRAFSSCALQFGSALGINSDTRALQFGSHAFGACLLEIMTTLIHGGCVCIPSDDDRMNNVPAFVNRANVNWMMATPSYMGTFQPDDVPGLKTLVLVGEQMSPSVNAIWAPRVQVLDGYGQSESSSICFVGKISSSGADPNNIGHSVGAHSWIIDPSDPNRLVPIGAIGELVIESPGIARDYIIPPPTENSPFFSTVPPWYPFKELPNGIKFYRTGDLARYASDGTVVCLGRMDSQVKIRGQRVELGAVETHLRQQLPDDMSIVVEAVKPSDLPTSTVLVAFLITEATKSVRDATILDLAATKAMSVKLEHVLPRHSIPSCYISMQHLPRTATGKVDRRKLRSIGRDMLAQQLQGTSFRPSQLSSTTTSSQSKLEEVWRQCLGLEPGAANINSTFFELGGHSITAIKMVNMARSAGIDLKVSDIYQNPTLAGLEAIVNGSAEPYAIIPTTTRDGPVEQSYSQGRLWFLDQLEVGALWYLIPYAVRMRGLVDIDALSRALMALEQRHETLRTTFEDCDGAGVQIIHKILSKKLRVVDAPDSDYLDLLKQEQTTPFDLTSEAGWRALLIRLNDTDYILSIVMHHIVSDGWSIDVLRHDLSQLYAAALQGRDLASAMNPLPIQYSDFAMWQKQEAQALEHEKQLDYWKRQLADCSPAKLPTDFPRPALLSGEAGVVPVSIDRQLYQNLRDFCNENNTTSFAVLLAAFRAAHYRLTGVDDAVIGTPIANRNRWELENIIGFFVNTQCMRITVDDQDTFGSLVSQVRATTTAAFENEDVPFERVVSTMLPGSRDLSRTPLAQLIFAVHSQKDLGRFELQGLESEVVASKAYTRFDIEFHLFQEADGLRGSCNFATDLFRPETVENMVSVFFQILRNGLEKPNIPISVLPLTDGIEELRRLDLLRIKKVEYPRDASLVDIFRTQVAAYPDSLAVVDSSSRLTYTELDLQSDRLAARLRRQGMPAETLVGVLAPRSCEAIVAIIGILKANLAYLPFDVKSPSARLEDILSSIPGQTIVLLGSDVPVPELSIPGLEFMRIVDAIECCDTNNLNGHAHVDNSNPTATSLAYVLFTSGSTGRPKGVMVEHRVIVRLMTSNIIPDFPVQPRSAHMFNIAFDGATYEIFFTLLNGGTLVCIDYMTTLDVKALQDVFLKEKINAACMAPALLKLYLTDARDALRGLDFLMAAGDRFDGQDAIEAQSLVRGQCYNGYGPTENGIMSTRYPIAVGDSFINGVPIGRAVNNSGAYVTDLNQQLVGVGVMGELVVTGDGLARGYFDPALNENRFIHIEVDGQRVRAYRTGDRVRYRVGDGLIEFFGRMDTQFKIRGNRIESAEVEAAMLGHGSVRDAAVVVQKDDGEKADLVGFVVIDHDHSLEGDANDNQVEGWQDHFETEMYADIGDIDPFTIGKDFKGWTSMYDGSEIDKVEMQEWLDDTIKTLRDGQAPGHVLEVGTGSGMILFNLGDGLQSYRGLEPSKSAAAFTNSVIKSVPSLASKAEVHVGTAQDVSQLTDLHPDLVVINSVAQYFPSPEYLAQVADTLIHIPGVKRLFFGDMRTNATNKHFLAARAIRTLGDTATKDFVRQKMAELEEREEELLVEPAFFTALQDRFPDLVHHVEILPKNMHATNELSAYRYAAVVHIRDSDSVPVHTIEKSTWVDFGASRMDRTSLLQFLRRSKGSPTVAISNIPFAKTIFERQIVESLEAEDESKLDGAVWISAVGSDADSRASLSVPDLRRLAEEAGFRLEVSAARQWSQSGALDAVFHHLPSPSDTRRTLIKFPNDNHLRSSATLSNRPLQGLQRRRATLQVRERLQSLLPSYMIPSSIVVLDQMPLNPNGKVDRKELARQARIMPKQQTALPVQAVPISDIEAILCDEATATFGMKVDISDDFFKLGGHSLLATKLISRVEQRFNVRVTVKDVFDNPVFANLAVVIREGLASRTTLTNSQDKQGWSARVAPRTETEITLCDEASKLLGIEVGITDNFFDLGGHSMMATKLAMRLGRRLDTTIVVKDIFDYPVLFQLSKKLESTDSGTDNEEVQVDDYTPFELLSLENPQDFIQRQICSQLNVSLESIQDMYQSTQMQKSFLFSPGTGSPRPLTPFYIDFPVDSDPPTLVNACHSLVQHIDMFRTVFVLASEQLYQVVLKHLEVPIETIVTNQNVNTATNDFLVEHAQDPIRLGESLIRIAILKQSSSVRVLLRLSHALYDGLSLEPIVRNLHILFNGMSLLPPTQFRRYMEYTANSQEKGFEFWRDVIGDSPMTILSDAGNGAYHREVSPSKALHLSKVVSVPSQAIRSSIATQATVFNSACALVLSKESRSSDVVFGRIVSGRQGLPVNCQDIIGPCTNAVPVRAHIGTDGNHHQMLRDMQDQYLRSLPFETLGFEEIKRNCTDWPDSTTNFACCVTYHNFEYHPESEVEQQRVEMGVLSKHVELRKDEPLYDLAIAGEVEPDGMSLKVTIIARAHLFEEERVQYFLEEVCNTFQTLNFSL
What is the function of this protein?
Beauvericin nonribosomal cyclodepsipeptide synthetase; part of the gene cluster that mediates the biosynthesis of beauvericin (BEA), a non-ribosomal cyclic hexadepsipeptide that shows antibiotic, antifungal, insecticidal, and cancer cell antiproliferative and antihaptotactic activity (PubMed:25543026, PubMed:27750383, PubMed:28125067).  Ketoisovalerate reductase BEA2 catalyzes the NADPH-specific reduction of ketoisovaleric acid to hydroxyisovalerate, a precursor for beauvericin biosynthesis (By similarity).  The nonribosomal cyclodepsipeptide synthetase BEA1 then catalyzes the formation of beauvericin via condensation and cyclization of 3 dipeptidol monomers, each composed of one unit of hydroxyisovalerate and one unit of N-methyl-phenylalanine (By similarity).
What are the official names of this protein?
Beauvericin nonribosomal cyclodepsipeptide synthetase BEA1, BEAS, Beauvericin biosynthesis cluster protein 1.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.