PharMolix/UniProtQA huggingface dataset:
Protein: TXR1_MACRV
Sequence: CGTNRAWCRNAKDHCCCGYSCVKPIWASKPEDDGYCWKKFGGC
What is the function of this protein?
This toxin blocks the neuromuscular transmission, and also acts on muscle.  It exerts an effect of first exciting and then inhibiting the contraction of muscle.  This toxin is active only against mammals.
What are the official names of this protein?
U5-hexatoxin-Mr1a, U5-HXTX-Mr1a, Raventoxin I, Raventoxin-1.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CIAO1_CULQU
Sequence: MGKLTLLQCLSGHRGRVWGAGWHPRDPVLATCGEDKTIRIWADDGTGRWVPKTVLSDGHTRTIRDVAWSPCGRFLASASFDATVAIWDRRSGEFECNATLEGHENEVKSVSWSKSGALLATCSRDKSVWIWEVAQEDEYECAAVLNTHSQDVKKVEWHPNEDVLASASYDNTIQLYREDLADSDWSSFDTLASHDSTVWSIAFDASGSRLASCSDDQTVRIWQEYKPGNEFGVACPDGKTPVWKCVCTLSGFHSRAVYDISWCKKTGLIATACGDDMVRIFREVAGSPANEPTFEMVASKHAHSQDANTVEWSPTVAGLLVTTSDDGDVKLWKFEDDE
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for the maturation of extramitochondrial Fe/S proteins.
What are the official names of this protein?
Probable cytosolic iron-sulfur protein assembly protein Ciao1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CIA1 family.
Protein: SIM2_HUMAN
Sequence: MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSCGHYREEPALGPAKAARQAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLLNYHRVLARRGPLGGAAPAASGLACAPGGPEAATGALRLRHPSPAATSPPGAPLPHYLGASVIITNGR
What is the function of this protein?
Transcription factor that may be a master gene of CNS development in cooperation with Arnt.  It may have pleiotropic effects in the tissues expressed during development.
What are the official names of this protein?
Single-minded homolog 2, Class E basic helix-loop-helix protein 15, bHLHe15.
What are the subcellular locations of this protein?
Nucleus.
Protein: PA2B1_BUNMU
Sequence: MNPAHLLVLSAVCVSLLGAANIPPHPLNLINFMEMIRYTIPCEKTWGEYADYGCYCGAGGSGRPIDALDRCCYVHDNCYGDAEKKHKCNPKTQSYSYKLTKRTIICYGAAGTCGRIVCDCDRTAALCFGNSEYIEGHKNIDTARFCQ
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 beta-bungarotoxin A1 chain, Beta-BuTX A1 chain, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RPOZ_ECOK1
Sequence: MARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAELQAVTAIAEGRR
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RF2_HELPS
Sequence: MDNYTYSELLKSLQNKCDNIALIIKPEKIKQELERIEKEQEDPNFWQDVLKARDTNKEKVRLNRLLETYQKTKNSLDESTELFELAQNDNDEVTLSLLYEEAPVLEHSVQKVEIEIMLSGENDASNAIITIQPGAGGTESQDWASILYRMYLRWAERRGFKSEILDYQDGEEAGIKGVAFIIKGENAYGYLKNENGVHRLVRISPFDANAKRHTSFASVQISPELDDDIDIEIDEKDVRYDYYRASGAGGQHVNKTESAVRITHFPTGIVVQCQNDRSQHKNKASALKMLKSKLYELELEKQQSTAKNEEKSEIGWGHQIRSYVLAPYQQVKDARSNTAYSNVEAILDGDIDAILEGVLIAKA
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_VESOH
Sequence: MLNEIQQNSQNKMNKSINSLKNAFSKIRASRAHPSLLEQIHINYYGSMVPLSQVANISTEDSRTLKASPWEKDMVSVIEKAIMTSDLGLNPQTIGQVIRIHLPPLTQERRGELVKIIKDEAEKAKIAIRNIRRDANSDFKELLKEKEISKDEARKAEYDIQKITDEYIKKIEINLNKKEDSLLEI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS81_CUPPJ
Sequence: MAEQGKQGGKVPFGPDYVRAISPYIAGKPISEVAREFGLDEAGIVKLASNENPLGMPESAKHAAAAAIAELGRYPDSNGFELKAALSTKLGVPQDWLTLGNGSNDILELAAHALVTPGQSIVYAEYSFAVYALATQEIGARAIVVKARDYGHDLDAMAAAITSDTRLVFIANPNNPTGTFVPAAALETFLAKVPAEVVVVLDEAYNEYLDDDQQYDSVAWVRRYPNLLVSRTFSKAYGLAGLRIGYAVAQPELTDLLNRIRQPFNVNSVAQAAAVAALGDTAFLQRSAELNRAGKAQLVEAFSRLGLEFVASSGNFVLVRVGDDDDAGARVNVALLRQGVIVRPVGNYGMPRWLRVTIGLPDENAAFIAALERALK
What are the official names of this protein?
Histidinol-phosphate aminotransferase 1, Imidazole acetol-phosphate transaminase 1.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: EFGM1_ARATH
Sequence: MARFPTSPAPNRLLRLFSSNKRSSSPTAALLTGDFQLIRHFSAGTAARVAKDEKEPWWKESMDKLRNIGISAHIDSGKTTLTERVLFYTGRIHEIHEVRGRDGVGAKMDSMDLEREKGITIQSAATYCTWKDYKVNIIDTPGHVDFTIEVERALRVLDGAILVLCSVGGVQSQSITVDRQMRRYEVPRVAFINKLDRMGADPWKVLNQARAKLRHHSAAVQVPIGLEENFQGLIDLIHVKAYFFHGSSGENVVAGDIPADMEGLVAEKRRELIETVSEVDDVLAEKFLNDEPVSASELEEAIRRATIAQTFVPVFMGSAFKNKGVQPLLDGVVSFLPSPNEVNNYALDQNNNEERVTLTGSPDGPLVALAFKLEEGRFGQLTYLRVYEGVIKKGDFIINVNTGKRIKVPRLVRMHSNDMEDIQEAHAGQIVAVFGIECASGDTFTDGSVKYTMTSMNVPEPVMSLAVQPVSKDSGGQFSKALNRFQKEDPTFRVGLDPESGQTIISGMGELHLDIYVERMRREYKVDATVGKPRVNFRETITQRAEFDYLHKKQSGGAGQYGRVTGYVEPLPPGSKEKFEFENMIVGQAIPSGFIPAIEKGFKEAANSGSLIGHPVENLRIVLTDGASHAVDSSELAFKMAAIYAFRLCYTAARPVILEPVMLVELKVPTEFQGTVAGDINKRKGIIVGNDQEGDDSVITANVPLNNMFGYSTSLRSMTQGKGEFTMEYKEHSAVSNEVQAQLVNAYSASKATE
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G-1, mitochondrial, EF-Gmt, mEF-G 1-1, Elongation factor G1-1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RLMKL_ECOLI
Sequence: MNSLFASTARGLEELLKTELENLGAVECQVVQGGVHFKGDTRLVYQSLMWSRLASRIMLPLGECKVYSDLDLYLGVQAINWTEMFNPGATFAVHFSGLNDTIRNSQYGAMKVKDAIVDAFTRKNLPRPNVDRDAPDIRVNVWLHKETASIALDLSGDGLHLRGYRDRAGIAPIKETLAAAIVMRSGWQPGTPLLDPMCGSGTLLIEAAMLATDRAPGLHRGRWGFSGWAQHDEAIWQEVKAEAQTRARKGLAEYSSHFYGSDSDARVIQRARTNARLAGIGELITFEVKDVAQLTNPLPKGPYGTVLSNPPYGERLDSEPALIALHSLLGRIMKNQFGGWNLSLFSASPDLLSCLQLRADKQYKAKNGPLDCVQKNYHVAESTPDSKPAMVAEDYTNRLRKNLKKFEKWARQEGIECYRLYDADLPEYNVAVDRYADWVVVQEYAPPKTIDAHKARQRLFDIIAATISVLGIAPNKLVLKTRERQKGKNQYQKLGEKGEFLEVTEYNAHLWVNLTDYLDTGLFLDHRIARRMLGQMSKGKDFLNLFSYTGSATVHAGLGGARSTTTVDMSRTYLEWAERNLRLNGLTGRAHRLIQADCLAWLREANEQFDLIFIDPPTFSNSKRMEDAFDVQRDHLALMKDLKRLLRAGGTIMFSNNKRGFRMDLDGLAKLGLKAQEITQKTLSQDFARNRQIHNCWLITAA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.  Methylation occurs before assembly of 23S rRNA into 50S subunits.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_CHLFF
Sequence: MKEAPVIKLRELLNLLPHRYPFLLVDKVLSYDLEKRSIVAQKNVTINEPFFVGHFPEAPIMPGVLILESLAQAAGVLLGLVLENDRNKRLALFLGIQKAKFRHAVRPGDILTLSAEFSLISSKGGKASARACVGSQVAAEGELSFALVDKESLD
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANR_SALAR
Sequence: MDVMNAFDSQAEDSPLTIGHSLRRRPLARKKLSEMVEEELEQMIRRHEFGEGEQLPSERELMAFFNVGRPSVREALAALKRKGLVQINNGERARVSRPSADTIISELSGMAKDFLTHPGGIAHFEQLRLFFESSLVRYAAEHATDEQIALLTKALEINSQSLDDNALFIRSDVEFHRVLAEIPGNPIFMAIHVALLDWLIAARPSVPDRELHEHNNVSYQQHIVIVDAIRQRDPDKADRALQTHLNSVSATWHAFGKKSQKTR
What is the function of this protein?
Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.
What are the official names of this protein?
HTH-type transcriptional repressor NanR.
What is the protein family that this protein belongs to?
Belongs to the NanR family.
Protein: VEGFH_ORFN2
Sequence: MKLLVGILVAVCLHQYLLNADSNTKGWSEVLKGSECKPRPIVVPVSETHPELTSQRFNPPCVTLMRCGGCCNDESLECVPTEEVNVSMELLGASGSGSNGMQRLSFVEHKKCDCRPRFTTTPPTTTRPPRRRR
What is the function of this protein?
Induces endothelial proliferation.
What are the official names of this protein?
Vascular endothelial growth factor homolog.
What is the protein family that this protein belongs to?
Belongs to the PDGF/VEGF growth factor family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL7_STRGC
Sequence: MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAVAAAGAADAGAAKDSFDVELTAAGDKKVGVIKVVREITGLGLKEAKELVDGAPGIIKEGVATAEAEEIKAKLEEAGASVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: FAD3_RICTY
Sequence: MQNEIKKVCVIGAGVMGSGIAALIANSSHRVVLLDILDKDSNDPNKIVKNAVKNLHRQKLPPLSYPDKVNFITIGNLEHDLDLIKECNLVIEVIVEKLDIKHQLYNKIIPYLKEDTIIASNTSTLPLKKLKENLPNNIKSRFIITHFFNPPRYMELVELIIDNTIKDEVIEKISVFLTKILGKTIIKCNDTPGFIANRVGCFLLELVAHKAIAQNLDFVTIDQIFSRCLGLPNTGIFGLYDLIGHDVMKLISSSLLSALPKSDDYHRIYFNTKVFDKMIEHNLIGRKGEGGFYRLSVSNGKKIKEVINISDLSYHPVQKVDISFNNLDELLASDSIYSKFFSEIITEFYIYLTSLVPSVTNNIYDIDATMKLGYSWHYGPFELLTIAVKNGWNSIIKNADLMNISLPKYLASKEYQKIDKQKFNSKKDFLQESTIVLANDSANLIHYCENLIFVITTKMNTLNHNVFYLLQEAVSKAENYGKNLYIFPQGNNFSAGADLKLILSYIQDGNFDNLENLLKLGQQTMRYLKYSSVHIISCARGVALGGGCELLLNSSYIVANQELNAGLIEFGVGLIPGWSGVTEMFARSNGDKTKLIRNIKNIIEQNKTSSADYFKADYDVSNMQVNMNKHYILDEALKLNVSNKIVSIPHKIALPKINIVSEIDTSKYNDLQNKVLNKFQNIIDKHNEISEAELLTYEREIFLELAKEPQTIEKLHAIVG
What are the official names of this protein?
Putative fatty acid oxidation complex trifunctional enzyme.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
Protein: MCES_CRYNJ
Sequence: MVYDPIRDCDVPAPHISAPPLSRSRSPPPPHRTPSASGSLRGLLNDSPPPREPPRAASVHEDAESHRPKLSNILNDAEPPRQRSMLPPQQPIHAELEHGRRTSAGSHAAQLARSPSMSLSPRSQNQSLPYPSSRPGSAAGSAHPFGYDPRQGTLSPVLSARRTSEDQPRPTSSSSASGRRYTEPASQTPAPAPLGSSAYRPRHTSTPGNPSSAYAPRFTPQPTTTPSSPSTSQHTPYTPHHSAPPRILHYNPHRQSAPSSVLRPIYPDEVAHLRQLAHANNPLRQKPAARRYSYSGGRAPEPTPTPRTSLPGENDHSYFPPQWDDRPSMPPSEVSYGGPPSSTPGAPPSGYSQYPPNWEAQTPGGNWDGERPGRLGKRRARDEEDDEYERNKRVVSGPVAGQAYSKKVTVVAEHYNSRPEVGVERREFSPIIGLKKFNNWIKSVLIGKFAYRPRGKVLDVGCGKGGDLNKWKQARIALYVGLDVADQSVQQAADRYRRMPKPGFDAFFYAHDCFSNPLSDVLSPELQIKDLYDNVTMQFCMHYAFENAAKARMMIENVSRYLRRGGIFIGTIPNAELLLQLPDRDEELRFGNSCYSIQFTERRHKGVYGHDYRFYLTDAVEDVPEYLVDWENFVSLASESGLRLVYKKAFHEILQEEKDSRDFGPLLGKMGVLNEYGESAMDADQWEAANLYMGFAFEKM
What is the function of this protein?
Responsible for methylating the 5'-cap structure of mRNAs.
What are the official names of this protein?
mRNA cap guanine-N7 methyltransferase, mRNA (guanine-N(7))-methyltransferase, mRNA cap methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSPL1_GOSHI
Sequence: MEKSEKGNGVAPATRSPMALMGSSRNENQEVNTSMRTAETMLRLVPMALGVAALVVMLKNSQSNDFGSVSYSDLGAFRYLVHANGICAGYSLLSAIIAAVPSPSTMPRAWTFFLLDQILTYVILGAAAVSTEVLYLANKGDSAITWSAACGTFAGFCHKATIAVVITFVAVICYAVLSLVSSYRLFTKFDAPVNYPSKTIEATVFHG
What are the official names of this protein?
CASP-like protein F16, CASP-like protein 2A1, GhCASPL2A1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DEGP_ECO57
Sequence: MKKTTLALSALALSLGLALSPLSATAAETSSATTAQQMPSLAPMLEKVMPSVVSINVEGSTTVNTPRMPRNFQQFFGDDSPFCQEGSPFQSSPFCQGGQGGNGGGQQQKFMALGSGVIIDADKGYVVTNNHVVDNATVIKVQLSDGRKFDAKMVGKDPRSDIALIQIQNPKNLTAIKMADSDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNAENYENFIQTDAAINRGNSGGALVNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELNSELAKAMKVDAQRGAFVSQVLPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVGSKLTLGLLRDGKQVNVNLELQQSSQNQVDSSSIFNGIEGAEMSNKGKDQGVVVNNVKTGTPAAQIGLKKGDVIIGANQQAVKNIAELRKVLDSKPSVLALNIQRGDSTIYLLMQ
What is the function of this protein?
DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures.  It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions.  DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids.  Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins.  Its proteolytic activity is essential for the survival of cells at elevated temperatures.  It can degrade IciA, ada, casein, globin and PapA.  DegP shares specificity with DegQ.  DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP) (By similarity).
What are the official names of this protein?
Periplasmic serine endoprotease DegP, Heat shock protein DegP, Protease Do.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GCH4_PSESM
Sequence: MNSPLPDVALTEVSSALIALDWVGMQGVEVPLTLGEQGATHPVHAYADLQVDLTDPSVKGIHMSRLYRLLDGFAEHQVLTPETLSALLEAMVESHVDCHSSGARITLTFNLLCRRPALVTEGLSGWKSYPVKLEAVWRAGRLCLDVSADITYSSTCPCSAALSRQLLEEAFVARFGRQSFVDPMQVAAWLRENASYATPHSQRSVATVQVRVAEQATEMGLMALIDTVEQALGTPVQTAVKRADEQAFARLNGQNLMYVEDAARKIQQALEGRYPASSVSVRHFESLHPHDAAAQTSSYLS
What is the function of this protein?
Converts GTP to 7,8-dihydroneopterin triphosphate.
What are the official names of this protein?
GTP cyclohydrolase FolE2.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: MDTD_ESCF3
Sequence: MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSATLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLAIAGLAAIGVVALVLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQHVSVDSSTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ
What are the official names of this protein?
Putative multidrug resistance protein MdtD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ISPE_FRATM
Sequence: MANIKAKKYYSYAKINLFLHILNKRTDGYHNLQTWFTFLDLKDQLTFSFNNSREINISSNISIAAKQDNLVYKAIKKFQQSYRVQDIGVDIEIKKNIPMGAGLGGGSSNAATTLIALRDYYLPQLSNEEMIPLAAKLGADVPIFVYGKSAWAEGIGEILYHKDFSPQYALLIKPDIHISTKEFFTSEDLIKSSVLISKDLGFDKSIMHNDFENVFYAKYPEFSQYLKELDSDFRMTGTGSCFYLLSADKNKLEQLARKINKSLDKWLVKTLNYVY
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: SPEE_ECO7I
Sequence: MAEKKQWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVESITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFKLVIDDGVNFVNQTSQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQEEAIDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSTEIIQARFLASGLKCRYYNPAVHTAAFALPQYLQDALASQPS
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCSA_CAPBU
Sequence: MIFSILEHILTHISFSVVSIVLTIYFLTLLVNLDEIIGFFDSSDKGIIITFFCITGLLFTRWIYSGHFPLSNLYESLIFLSWSFSIIHMVSYFNKKQQNHLNAITAPSAIFIQGFATSGLLNKMPQSAILVPALQSQWLMMHVSMMILGYGALLCGSLLSIALLVITFRKVGPTFWKKNIKKKFLLNELFSFDVLYYINERNSILLQQNINFSFSRNYYRYQLIQQLDFWSFRIISLGFIFLTVGILSGAVWANETWGSYWNWDPKETWAFITWTIFAIYLHIKTNRNVRDINSAIVASIGFLLIWICYFGVNLLGIGLHSYGSFTSN
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein CcsA.
What is the protein family that this protein belongs to?
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RIP5_ORYSJ
Sequence: MAMIFLLAALSTTHLASSLRPVAAGACRPSGYLPGKSGNCEKSNDPDCCEDGKAYPQYRFEKGKDGGGPSECDNAYHSDGELVVALSTGWFAGTARCGHRVRITASGGGGRSVVAKVVDECDSVHGCDGEHNYEAPCGNNIVDASPAVWDALGLDKNVGMEHITWGREPQGKIPVQGFSMHQLNPSQSPGKRFLVGEISLPPFGSSSREWEMVSWKCFLPAFMSINYLHGSSHLRTKLNIKGEWQLDRYPFTTLQQHILSRKFVMLWCIQVKKNVL
What are the official names of this protein?
Putative ripening-related protein 5.
What is the protein family that this protein belongs to?
Belongs to the kiwellin family.
What are the subcellular locations of this protein?
Secreted.
Protein: BIOB_SPHAL
Sequence: MRTDWTREEIAALFDLPFDELMWEAQGVHRRHHARGEIQLCTLLSIKTGGCVEDCGYCSQSAHADTGLKATKLMDVRAVLQAAAQAKDAGSKRFCMGAAWRNPKDRDMPAIVEMIEGVRAMGMETCMTLGMLSKEQAQVLGMAGLDYYNHNIDTSPEHYGNVITTRSFQDRLDTLEEVRAAGINVCSGGIVGMGETRADRVGFIHTLATLPEHPGSVPINALVPVKGTVLGDMLADTPLAKIDDIEFVRTVAVARITMPKSMVRLSAGRESMSEATQALCFMAGANSIFTGDKLLTTANAGDNADAALFAKLGLRPMESEEPMRMEAAE
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: SPB6_BOVIN
Sequence: MDALSEANGTFALTLLKKLGEGNSKNVFISPLSISSALAMVLLGAKGNTAAQMCQTLSLNKSSGGGEDVHQGFQNLLSEVNRRDTQYLLRTANRLFGEKTYDFLSSFKDSCHKFYQAEMEELDFVSATEQSRKHINTWVAEKTEGKIRDLLPANSVNPMTRLVLVNAIYFKGNWDTQFNKEHTEERPFRVSKNVEKPVQMMFKKSTCKITYIGEISTQILVLPYVGQELNMVILLPSESTDLNTVEKALTYEKFIAWTKPDVMDEEEVEVFLPRFTLEESYDMEEFLQELGMTDAFEETRADFSGMSSGRGLHLSKVMHKSFVEVTEEGTEAAAATGAVVMMRCLMVVPRFNANHPFLFFIQHSKTGAILFCGRFCSP
What is the function of this protein?
Inhibitor of cathepsin G, kallikrein-8 and thrombin.  May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity).  May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood.
What are the official names of this protein?
Serpin B6, Proteinase inhibitor 6, Serine proteinase inhibitor B-43.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG59_BPMD2
Sequence: MQNRKHKRKPCKDCVAQGLPLTRDAKYPGPRCATHHREFKAARSSTSWETRILATYGITAEEYWAIYEFQGGRCYICQRANGKRKRLSVDHDHKTGIVRGLLCTMCNKYILGWARDCIEMLQRAIDYLRKPPAVQVIGERIAPIEADKLRSQT
What are the official names of this protein?
Gene 59 protein, Gp59.
Protein: MKRN1_MOUSE
Sequence: MAEAAAPGTTATTSGAGAAAAAVAAASLTSIPTVAAPSPGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYGVVCKYFQRGYCVYGDRCRYEHSKPLKQEEVTATDLSAKPSLAASSSLSSGVGSLAEMNSGEAESRNPSFPTVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEVPPQGSVTKEESEKEPTTVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPVDAAQRSQHIKSCIEAHEKDMELSFAVQRTKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLIQKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRSHFWELIEERENNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL
What is the function of this protein?
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.  These substrates include FILIP1, p53/TP53, CDKN1A and TERT.  Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions.  Acts as a negative regulator of telomerase (By similarity).  Has negative and positive effects on RNA polymerase II-dependent transcription.
What are the official names of this protein?
E3 ubiquitin-protein ligase makorin-1, RING-type E3 ubiquitin transferase makorin-1.
Protein: TTCA_PSEAE
Sequence: MGTLSVNQNKLQKRLRRLAGEAITDFNMIEDGDKVMVCLSGGKDSYTMLDILLYLQKVAPIRFEIVAVNMDQKQPGFPEHVLPEYLKSIGVEYHIVEKDTYSVVKEKIPEGKTTCSLCSRLRRGTLYTFADEIGATKMALGHHRDDILETFFLNMFYGGTLKAMPPKLLADDGRNVVIRPLAYCSEKDIEAYSQLKEFPIIPCNLCGSQENLQRQVVKEMLLEWERKSPGRTEIMFRALQNVVPSQLADRNLFDFANLRIDENATPRFLDVMNL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.