Protein: HIMA_ASPJA
Sequence: MAYIPSSSEPIAIIGSACRFPGHSTSPSRLWELLRNPYDLTKQVPEGRFNVDGFHHPDGEHHGTTNAPNGYWLEEDPRRFDSTFFNITPKEAEAIDPQGKVLLEAVYEGLESAGLTLEGCSGSQVGVYVGTMTADYDILTGKDELTFSQYCATGTSRAIISNRVSYFFHWNGPSMTIDTACSSSLVAMHQAVLGLRSGESTMACVAGANLMLSPEPFICESSLHMLSPDGKSKMWDQSADGYARGEGVGVVFLKTLSRALADGDHIECIVRETGVNSDGRTKGITMPSSLAQAALIQDTYRRSGLDALNPDHRCQYFEAHGTGTQAGDPTEAEAIYKAFFGEDEELQEDGSILVGSIKTIIGHTEGAAGVAGVLKAALALKHAQVPPNQHLKSMNPRVVPFTRRLHVPNTLIPWPSVRPGHPLRASVNSFGFGGTNSHAILESYVPAIHGGHLAASIEKPIEHPPGFPLVLSANSAEALKDKVEQYIELLESEPEIDLQDLAWTLATRRSELPYRVSFSPVAGRERLLQEMRERLQTTEGNSSLGVRSKTVNHERGRILGIFTGQGAQWPQMGQQLIQRSPRFKEVIQSLDAVLRSCPDPPAWSIAHELLAPPTSSRLSEAALSQPLCTAVQIALVDILHEAGVELAAAVGHSSGEIAAAYAAGILTAPDAILIAYYRGFHAGLAQGPEGCRGGMMAVGMGVNEALEFCEQPAFLHHLHIAASNSPASVTISGDLEPLKQAKALLDERGTFARLLKVDTAYHSHHMDRCAAPYLQSLQAANIAPLSLTRSCVWVSSVYGPSGAPTLRELSGRYWKDNMVQPVFFTEAVTRALTEEGPFDMALEIGPHPALQGPAVQTMQEVNGSALPYAGLLHRGRDDLASVISTMGLIWSLLGSSSIDFDALSVALGNERSDCRVVKDLPSYPWDHTHMYHRQPRMAKQYLNRPARPHELLGVRTSDDTESEWRWRNLLKPSTLPWLKDHRFQDQIIVPAAAYCVMAFEAARALTTKPVKLVEIQNLSIKRGITMSDDSQGVETIFMLRKEPTVPGEGVISASFILDFVPGDADAQGTNAVKGMVHLHLGEPSAETLPRRSLPPPSGLNRVDLDEFYGSIKDIGLGYTGPFRAMTSLQRRLDFATGTLPKPHPAETSTLPVAPSLLDACFQAAFAAYAAPGDGSLWTSFLPQEIQNIRFNLDLCPVNPGPAATVNVDAVITQFSSASPESPANFSGDICVFNANGNMEVQVEGLTVVALSSTGPANDCELFIETVYKPDPYTGIVEARTEGINEEYVALQRACMRIADHFLHPNRTAGKPQQTPEAMQTGLADSPFRGYLELLISCGRTAPSRLPTAITEILMHFNEQSALQSHIRASVSQISHRFPQLRVLEITLGELQKYVTDAVVAGLAAPFHSYSHLFETTEKDAPSLLSAQTSIQDSRFRLLAFDKTALLSEQFPDETFDLVILSDGNRKNATLTSQLDGVHQLLAPGGYVFCVHSTGIPLQDRLLNPQKHHQSLSLQTLLRATPRVQGDFDLISSWTSPLRTIALSIRQSMSADVRHLIMPLTATDVSYMSDTVLLIGGETGETAQLSYQLAAILRDKSLEVVTAPRLEDVVSTSMGTVKAVIVLSDLDKPVLSSVNSSEFTALKQILVPNMSVLWLTSGFRDDQPYHYGTVGLFRSIRTETPQLKLQILDVAHISGAETVIAECFLRLITYLDSESTPLWTSEPELVWDGQHLLIPRVLPIDDLNRRYNSTRRVVHNYQNASLQVVQVVARWNGDRYTHHAVEATPSKASAPADEHFVNLRVLYSSAWAIEIKKGFHAFVSVATDSASRHLLALSPTNSSLITIPATHVHALPATGLDLSALLNRIVATLLAQSLLRQASPGGLLVHEADSFFADTLQRLNDEVRLLCFSTTDLALDDNRFIRLHPLSTKDATKAAVPSSRISSVADFSLGLTPTALVGLKSSTCMLIKAMDSLVKTEASILDNGNALSTAQDALLVVRWVVETALEELGSTRKPHTTTRVSDVLDKGLQPLGAVLDWTENVHVPLRVNRFDPGSQMRGNKTYVMIGLTGELGQSLCQFMVSHGARHLVVASRNPDKSPAWKTDLEKQGATIQVLSVDVTNVDAVRQLRVDLETSMPPVGGIVNGAMVLSDGLFADMPVESLQKALAPKVLGSQNLHDVFSDVDLDFFVMFSSLTGVPGNQGQSNYTAANMFMAGLAAQRRKAGQAASVLDIGMVSGIGYINRTDGAKIYANLKRQGYMPISERDIHGMFIEAIHCGRPTSTTGAQLTTGLQRFGVEGEEPLYWHTDPRFSHHRVLRNAVHKSTVSSSVESLKSRISEVQSQTAIAAILTESFASHVEAMLHLDPGSLDKETAIINLGVDSLMAVEIRSWFLAEVEKDMPVLKVLGGSSVATLAEEVAKELFEDRSTSAPPPMDLDKNSFDLGSVHGSSTDPSSNSDSKSGFDGFSSDDSSDIANDDSDPTAQCDQIEPMSLSQARMWLPYLMLQDKTAYNCTTSYRLIGQLDIPRFERALRSLLQSHQAFRTLFYTDHETGEAMQAIVPTSSTFSLRKVGSANDSSDVKVEHDRVAQHVYELERGDSFIATLVTHRPDYHTVIFGYHHIILDGVSWQIFLQELDRFYADPQRRPSLGVDFLDFSTRQHHDLTSIPSLSKRQFWKMTFASGSLPESLPLFPFAKAPARMPLTQYRVTEYFVELDRSLAAKIRSASTTNQTTAFHFYLSVFSVMMYRMLGVTDLCIGMTDANRNDQAFLETIGLLLDMLPLRFRLDKTPSDESAFADHLRATRDIVYSALGNSGVPLETILQDIGAESSATELPLFQAVVNYRMGAIKHKSIGDLGLEYLSYEDAGHPFDFILTIDEDEGRAGLTLSMQDYLYDRAGANIFLDSYIHLLEFFATTPTERVATPPAFAPALERTAIELGTGPRLSDPWEEPTLVHRIDHMAAKYPSDVALGDERGSLSYKAMSDRVNAIATQLLAVGAQVSTRVAVFGTPSTDNICSLLAILRIGAIYVPCDVRSADERLRTILTESEATVVIVNRETSSRFAKFHPDTVQAVIQLATVPIQSSPVHNAATAAGLAFIMFTSGSTGTPKGIQLTHANFLTHVQAASAYMQLGREVVLQQSAASYDASLAQIFYALANGGRLVVADNLRDTVALASILEKEAVTFTLMAPSEYLLLMEYTGDILARCSEWKVAMCGGEAFPPRLKGDFGRLGHGELSVYNAYGPTEIAVASNIGEVAIPRKEAAGESNDGDESHVPIGSALPEYNVYLVNEDIEPVPLGCPGQIAVAGPAVSAGYLKNEPLTSDKFPLVGERFHPEKSTRVYLTGDLARMLSNGSMVYLGRIESDTQIKLRGIRVELGDIANAILKTSRGVIANAAVGVRNPGPDQFLVAYVVLSGEKGTKRPANVRQYLDQLLVDLPLPQAMKPAVAVDVGSSLPMTSSGKLDMRALNARPLPASGDEDGDEDTETETGADADADAGADTTLSDIHSKLREIWNRALGGHTSIPITPSSNFFAVGGSSLSLLKMQALVQREFDLRIALPELFRTSTFGAIAERILRGVSAGFTEEEVEDTVPSSSPVDIIDWKKETALSETLRSLASSSQSDTRSPPMRRRPLTVILTGATGFLGRAIARALQARDDVLHIHCIAVRNPHSSAALELERTCDKVILHAGDLALPFLGMMEEEARLVFEEADVIVHNGADVSFLKSYQTLRGPNLRATQTLVEMTAHRQVPFHFVSTAGVATTLSEGSSPVIDEISLANHPPPTSRTGDAVLIDGYVASKWASETFLEHVHAQLALPVRIYRPSSITGADAPALDVMHNVLNLSRRMRALPDLGTWTGYFDFIRVETVAEEIAAGVTASPTPTATTPTPSGVEFIHLSGEKLIPVAEARKHLERETGYAFRTLEMAEWCREAAGYGLPALVAGYLESLEGQALSFPRLRSRIAEWGGGGREVVAV
What is the function of this protein?
Polyketide synthase-nonribosomal peptide synthetase hybrid; part of the him gene cluster that mediates the biosynthesis of himeic acid A, a ubiquitin-activating enzyme (E1) inhibitor (PubMed:29314577).  First, himA, together with the trans-enoyl reductase himH, catalyzes the formation of apolyketide chain, which is then condensed with leucine by the NRPS activity of himA.  Dieckmann cyclization and release from himA gives a tetramic acid intermediate as the product of himA PKS-NRPS (PubMed:29314577).  HimG then catalyzes alpha-oxidation of the tetramic acid ring, with a subsequent rearrangement to yield apyrone intermediate (Probable).  Two terminal methyl groups of polyketide and amide side chains are oxidized to carboxylic acids by himC cytochrome P450 monooxygenase to form himeic acid A (Probable).  Himeic acid A is further converted to himeic acids B and C during culture growth.  No gene responsible for pyrone to pyridone conversion was found in the him gene cluster and himeic acid A is non-enzymatically converted to himeic acid C by the incorporation of an ammonium nitrogen atom in a pH5 buffer, and to himeic acid B at a conversion ratio of 50% during incubation in MeOH for 5 days (PubMed:29486950).
What are the official names of this protein?
Polyketide synthase-nonribosomal peptide synthetase hybrid himA, PKS-NRPS hybrid synthetase himA, Himeic acid biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.