PharMolix/UniProtQA huggingface dataset:
Protein: RS12_LAWIP
Sequence: MPTINQLIRHERKKVVKRKKTPALQGCPQRRGVCTRVYTTTPKKPNSALRKVARVRLTNGLEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGTLDTSGVQDRRQRRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: DBP3_BOTFB
Sequence: MPKRTLEDTELNSGDNDIKISSKKSRKEKKDKKEKKSKDVEEPTTESTPIEVEVESKEARRERKRLKKEKKAQEAEKETEEEEKSGVEAIEPASDANAAADAKAAKKAEKARLKALKKEGKEEKADSTKSIETAAPASVTPQQNGTTYTEDPNLSGLPQSEIDSFLTTHFITITDPLSTSATLRPLTKFDYLPITDPAQRAPFKDFKAPTPIQAAAWPFLLAGRDVIGVAETGSGKTMAFAVPCINKGPRAVVVSPTRELAMQSYEQIVKLAKASGLECVCVYGGVPKDEQIRALKTADIVVATPGRLNDLINQGCADLSKARYVVLDEADRMLDKGFEEEIRKIINTTPSLGKRQTLMFTATWPESVRELAATFMTSPVKIAIGDNPTGDLRANSRIVQKVEVVEPRDKEYRLMQLLKQYQSGSQKDDRILVFCLYKKEATRVESFIRQKGFRVAGIHGDLSQEQRTRSLEAFKSGNTPVLVATDVAARGLDIPAVKLVINCTFPLTVEDYVHRIGRTGRAGKDGLAITLFTEHDKAQSGALINVLKAANQPVPDELLKFGTTVKKKAHDAYGAFFKNVDTTKKATKITFD
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase dbp3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DLTA_STAA2
Sequence: MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNKQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTATPINIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERLGARLSTTDDGELVIEGQSVSLGYLKNDQKTAEVFNFDDGIRTYHTGDKAKFENGQWFIQGRIDFQIKLNGYRMELEEIETQLRQSEFVKEAIVVPVYKNDKVIHLIGAIVPTTEVTDNAEMTKNIKNDLKSRLPEYMIPRKFEWMEQLPLTSNGKIDRKKIAEVING
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_RHOP2
Sequence: MGSLSIWHWIVVIAVVLLLFGRGKISDLMGDVAQGIKSFKKGLQDDEKTAEKPDAVKSLDHNATTGTPPNRTDVGSKAV
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: PROA_CHLCH
Sequence: MKDQIIQKLHDVVRASRELVTLSDEAINRLLLDLADQIPNHQTAILEANQRDIERMDSANPMVDRLLLNEARLQAIAADIRNVASLPTPLDAVLEKRTLPNGLELKKVSVPMGVIGIIYEARPNVTFDVFALCLKSGNATVLKGGSDAMYSNIAIVELIHSVLQQHGINPDTLYLLPAEREAAAVMLGAVGYIDMIIPRGSQKLIDFVRDNSRVPVIETGAGIVHTYFDVSGDLELGKQVIFNAKTRRPSVCNALDTLVIHRDRLGDLSYLVEPLQSRQVELFVDDAAYQELHGFYPKALLHQAKPEHFGTEFLSLKMSVKTVANLDEALEHIATYSSRHSEAIIATDAATVATFMKRVDAAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALREMTTYKWLIVGNGQVRPA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIO_BUCAI
Sequence: MNKIIELTDQNFEEQVLNSKSFFLVDFWAQWCNPCKILAPILEEISKEYSNKVIVGKLNIEENPNTAPVYSIRSIPTLLLFNNSEVLATKVGAVSKLELKEFLDENIN
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: Y3605_XANCP
Sequence: MSDLLNAAALDQLFRTARTQNAFLDTPVSEDLLRELYDLVKWGPTAANGSPARFVFVTTAEGKEKLKPALSEGNAAKTLAAPVTAIIGFDEDFHEKLPYLFPHADAKSWFDGPRTARTESAFRNSSLQGAYLILAARALGLDAGPMSGFDNAKVDAAFFAGTPIKSNFLVNLGYGDPAGLFPRLPRLSFDEAARIA
What are the official names of this protein?
Putative NADH dehydrogenase/NAD(P)H nitroreductase XCC3605.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family. HadB/RutE subfamily.
Protein: ADDB_LATSS
Sequence: MSLKFILGTASYDHHQALVTNLKATFQEKPQERYFYLVPNHIKFESEVSILEALKSDENDYVAASQIQVFSLTRLAWYFMKNTPYYQIPRISTAGLNMLVFRLLQEHQEQLQLFRGEVRHTGFVAQLTKQLLELKIGCITPADLTAMAENLGDQQVELAKKLHDLTIIATAFEAAMQKRFIENTALIDALTLFLQQQTLTDCHFYVEGFAQFTAQEQALLTTLMQQSEVQIGFILDRAYPNQQPDGLNFFFQAGRTYYNLYQQARLNHVPVMMDQMADSQRLTPALAALDQFWVSSESPGNRKLSPVPVADHLHVVAAENRYAELRYVAREIRRLVQTGHYRYRDFLILTRHLAPYQTMIAPILTEYEIPYFCDLPQTMAAHPLVSLLEKLLDVNLHFYRYEDVMALLKTELLIPKGMSIAEFRADLDLCENLILKNGYEGKDWLNDFDWQFYRFGSYQEGTRTTQDEALTERINGIRRYVQATLPPFYRALKAAKTGRQVVQVLYQFLIDHGVDRQLLHWRDQALAANQVAQAGQPEQTWSTFMQMLDEYVTLLGDVSFEEDNTEQLNEFKQLLSAGFAAAQYAQIPSTLDQVVLSESGMVQTKKRQITFMIGSTDQVMPDQIENTALLTDQDRQRLLDNEGQVTPLLNESSVGKMNAEPYLNYLAFLSSQTTVYFTYPLGNGEGTAFKISPYVERIRNHFDLTIQKIAAEQSLQSTETPQGSWRSLLSDLIQVSRQAQENQTLIPEQWLTTYRLLQQAPQSQFLTTQLFQSLNYRNEPERLTPEIVTGLYGNEIHTSISKLEEFYQNQYAYFLKYGLKLQERPVFELTPANTGNFYHEVMDRFIKLIQGQQIALPELDDQQIDKLVSEVLAKTYEQPEFKILNKTARMGYIRQQLMQTVKRVSLALRNQSLSTNLRPLATEVLFGQVGAEKGLQGLNFMLDDHREVKVRGKIDRIDQLTINNQPYLGIVDYKSSQHSFNFRDAYYGLALQMLTYLETVLQDQQAILPANSAVKPAGAFYLHLKNPTLTLKQLTKKKMGQLQKGEFDQMLLDQFKYNGLIVNDEELLENLDTTLVNGQSPLFAFSKLKSGKFSSKQLVTLNQLDLLMAHNEDLIKEAGQAIFAGDTALNPIMRPDRTNALTLSPFKSIFQFDAMLPENNYRQLEALDEKAVLERLMSKKGDGNLE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: TPIS_SODGM
Sequence: MRHPLVMGNWKLNGSKHMVNDLTAALRNELSSVVGCDVAIAPPVTYLELAKHHLGGSRIALGAQNVDTHLSGAYTGEVSAEMLKDIGAKYIIIGHSERRTYHKESDEFIAEKFAVLKEAELIPVLCIGESEAENEAGQTEAVCARQIDAVLNSLGAKAFENTVIAYEPIWAIGTGKSATPAQAQAVHKFIRDHIAKHDAAIAEQVIIQYGGSVNAANAAELFTQPDIDGALVGGASLKADAFAVIVKAAAEAKQS
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PERI_BOVIN
Sequence: MSHPSGLRSSVSSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPGSSVRLGSFRGPRAGTGALLRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELNQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQLSVESQQVQHVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLSIKTTVPEVEPPQETHSRKMVLIRTIETRDGEQVVTESQKEQHSELDKSPQSY
What is the function of this protein?
Class-III neuronal intermediate filament protein (By similarity).  May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity).  Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity).  Plays a role in the development of unmyelinated sensory neurons (By similarity).  May be involved in axon elongation and axon regeneration after injury (By similarity).  Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity).
What are the official names of this protein?
Peripherin.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, axon. Perikaryon.
Protein: ACP_ECODH
Sequence: MSTIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDYINGHQA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCRI_SYNS9
Sequence: MTQIPSSDVPGMGRRQFMNLLTFGSVTGVALGALYPVARYFIPPKAAGSGGGTTAKDELGNVVTATGWLSTHPEGDRSLVQGLKGDPTYLIVEGADAIGSYGINAICTHLGCVVPWNSGANKFMCPCHGSQYDATGKVVRGPAPLSLALANVSVEDDNVFVSEWSETDFRTGDKPWWA
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex iron-sulfur subunit, Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein, ISP, RISP, Rieske iron-sulfur protein.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein. Note=The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.
Protein: GPAM1_HUMAN
Sequence: MARDLIGPALPPGFKARGTAEDEERDPSPVAGPALPPNYKSSSSDSSDSDEDSSSLYEEGNQESEEDDSGPTARKQRKNQDDDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSTQKSDKGRDDPGQQETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRMKEKLTKGDDDSSKPIVRESWMTELPPEMKDFGLGPRTFKRRADDTSGDRSIWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKSKAAEDKNKPQERIPFDRDKDLKVNRFDEAQKKALIKKSRELNTRFSHGKGNMFL
What are the official names of this protein?
GPALPP motifs-containing protein 1, Lipopolysaccharide-specific response protein 7.
Protein: ISPH_BART1
Sequence: MSGLPPLTIRLCGPRGFCAGVDRAIQIVLLALKKYSAPVYVRHEIVHNRYVVEGLQQRGAVFVEELDEIPEEHRNQPVVFSAHGVPKSVSEEARRYNLFYLDATCPLVSKVHKQAIRHQRHGRHVILIGHAGHPEVIGTMGQLEDGAVTLIETIEDALHYQPGDPDKLGFVTQTTLSVEDTAGILDVLQQRFPTLAAPAAESICYATTNRQDAVKAAAKGSDLFLIVGAPNSSNSRRLVEVAEKSGARQAILVQRADEINFENLKALSVVSLSAGASAPEIIIDEIISAFRARYNVTIELAETVVETERFLVSRELRDVILTSQDMAFVNGQANNAKNENQNTDMFTTKAE
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RAH1B_ARATH
Sequence: MAPVSALAKYKLVFLGDQSVGKTSIITRFMYDKFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVIVYDVASRQSFLNTTKWIDEVRTERGSDVIVVLVGNKTDLVDKRQVSIEEAEAKARELNVMFIETSAKAGFNIKALFRKIAAALPGMETLSSTKQEDMVDVNLKSSNANASLAQQQSGGCSC
What is the function of this protein?
Protein transport.  Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).  Binds GTP and GDP and possesses intrinsic GTPase activity (By similarity).
What are the official names of this protein?
Ras-related protein RABH1b, AtRABH1b, Ras-related protein Rab6A, AtRab6A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Cytoplasm, cytosol.
Protein: LT_POVLY
Sequence: MDQTLSKEERNELMDLLQITRAAWGNLSMMKKAYKNVSKLYHPDKGGDSAKMQRLNELFQRVQVTLMEIRSQCGSSSSQGYFSEDFYFGPTTFQYSPMDRDAVREDLPNPGEGSWGKWWREFVNRQCCDDLFCSETMSSSSDEDTPPAAQPPPPPAPSPEEEDEIEFVEETPSSCDGSSSQSSYTCTPPKRKKTEEKKPDDFPVCLYSFLSHAIYSNKTMNSFLIYTTLEKARQLYKTVEKSKIVVDFKASFSYQDEEGEGCLLFLITLGKHRVSAVKHFCVSQCTFSFIHCKAVVKPLELYKTLSKPPFKLLEENKPGVSMFEFQEEKEQSVNWQEICNFANEANISDVLLLLGIYIDFAVEPGKCGKCEKKQHKFHYNYHKAHHANACLFLESRAQKNICQQAVDQVLAAKRLKLVECSRIELLEERFLQLFDEMDDFLHGEIEILRWMAGVAWYTILLDNSWDVFQNILQLITTSQPKKRNVLIKGPINSGKTTLASAFMHFFDGKALNINCPADKLSFELGCAIDQFCVLLDDVKGQITLNKHLQPGQGVNNLDNLRDHLDGTIKVNLEKKHVNKRSQIFPPVIMTMNEYLLPPTIGVRFALHLHLKPKAYLKQSLEKSDLVAKRILNSGYTILLLLLWYNPVDSFTPKVQEKVVQWKETLEKYVSITQFGNIQQNIIDGKDPLHGIVIEEQM
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription (By similarity).
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.
Protein: LMA2L_BOVIN
Sequence: MAVALGPSGWWQRWRRRLSAREVSRMLLLLLLLGSGQGPRQVGAGQTFEYLKREHSLSKPYQGVGTSSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFRIHGQGKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQERVFPYISAMVNNGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEVPGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLPEMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQDQSRKRFY
What is the function of this protein?
May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins.  May function as a regulator of ERGIC-53 (By similarity).
What are the official names of this protein?
VIP36-like protein, Lectin mannose-binding 2-like, LMAN2-like protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
Protein: RS16_MARMS
Sequence: MVTIRLSRGGSKKRPFYHLNVADSRRARDGRYIERLGFFNPVARGQEERLRIDLDRVNHWVSQGAQLSDRAAQLVKDASKNA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: OPUE_BACSU
Sequence: MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFVTALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAADDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKLGLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEIDAVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWMIITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMSSISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTILDLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVYEIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK
What is the function of this protein?
Catalyzes the uptake of extracellular proline under high-osmolarity growth conditions.  Essential for the use of proline present in the environment as an osmoprotectant.
What are the official names of this protein?
Osmoregulated proline transporter OpuE, Osmoprotectant uptake, Proline uptake system.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FER_CHLFR
Sequence: MATYKVTLINDAEGLNQTIEVDDDTYILDAAEEAGLDLPYSCRAGACSTCAGKIKSGTVDQSDQSFLDDDQIEAGYVLTCVAYPTSDCTIETHKEEELY
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
Protein: LPTE_ECO7I
Sequence: MRYLATLLLSLAVLITAGCGWHLRDTTQVPSTMKVMILDSGDPNGPLSRAVRNQLRLNGVELLDKETTRKDVPSLRLGAVSISQDTASVFRNGQTAEYQMVMTVSASVLIPGRDIYPISAKVFRSFFDNPQMALAKDNEQEMIIKEMYDRAAEQLIRKLPSIRAADIRSDEEQTSTTTDTPATPARVSTTLGN
What is the function of this protein?
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.  Required for the proper assembly of LptD.  Binds LPS and may serve as the LPS recognition site at the outer membrane.
What are the official names of this protein?
LPS-assembly lipoprotein LptE.
What is the protein family that this protein belongs to?
Belongs to the LptE lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TIPIN_MOUSE
Sequence: MLEQEENGLFEIPDYEHVEDETFPPFPPPASPERDPADAEPEEGSGSGVPVPPKRTVKRNLPKLDATRLTSERGLPALRHVFDKTKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVENLGNKKEVQTCLKRIRLDLPIVHEDFVNNNDEVGEANGPDVSATGFDPFLTSSSDSRKFASEPTRSLTEEQQQRIERNKQLALERRQAKLLSNSQSLENDVTVEENSTGEDQEESNGLNIDTADGPHDVPFASTHEEEQCKAEETQLDHTNLD
What is the function of this protein?
Plays an important role in the control of DNA replication and the maintenance of replication fork stability.  Important for cell survival after DNA damage or replication stress.  May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.  Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
What are the official names of this protein?
TIMELESS-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the CSM3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL19_LEGPC
Sequence: MTNIIDQINAEQMQGKEIPDFNPGDTVLVQVKVIEGNRERLQAFEGVVIAKRNRGLNSAFTVRKISHNVGVERVFQTYSPIVDSITVKRRGDVRRAKLYYLRNLAGRAARIKEKLSGKKGD
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PBPA_MYCTU
Sequence: MNASLRRISVTVMALIVLLLLNATMTQVFTADGLRADPRNQRVLLDEYSRQRGQITAGGQLLAYSVATDGRFRFLRVYPNPEVYAPVTGFYSLRYSSTALERAEDPILNGSDRRLFGRRLADFFTGRDPRGGNVDTTINPRIQQAGWDAMQQGCYGPCKGAVVALEPSTGKILALVSSPSYDPNLLASHNPEVQAQAWQRLGDNPASPLTNRAISETYPPGSTFKVITTAAALAAGATETEQLTAAPTIPLPGSTAQLENYGGAPCGDEPTVSLREAFVKSCNTAFVQLGIRTGADALRSMARAFGLDSPPRPTPLQVAESTVGPIPDSAALGMTSIGQKDVALTPLANAEIAATIANGGITMRPYLVGSLKGPDLANISTTVGYQQRRAVSPQVAAKLTELMVGAEKVAQQKGAIPGVQIASKTGTAEHGTDPRHTPPHAWYIAFAPAQAPKVAVAVLVENGADRLSATGGALAAPIGRAVIEAALQGEP
What is the function of this protein?
Transpeptidase that catalyzes cross-linking of the peptidoglycan cell wall (Probable).  Required for the regulation of cell length.  Plays critical roles for the survival of the pathogen inside the host.  Required for both bacterial survival and formation of granuloma structures in a guinea pig infection model (PubMed:29530985).
What are the official names of this protein?
Peptidoglycan D,D-transpeptidase PbpA, Penicillin-binding protein A, PBPA.
What is the protein family that this protein belongs to?
Belongs to the transpeptidase family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: HEPS_PONAB
Sequence: MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCVEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLATICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLAVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
What is the function of this protein?
Plays an essential role in cell growth and maintenance of cell morphology.  May mediate the activating cleavage of HGF and MST1/HGFL.  Plays a role in the proteolytic processing of ACE2 (By similarity).
What are the official names of this protein?
Serine protease hepsin, Transmembrane protease serine 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.