PharMolix/UniProtQA huggingface dataset:
Protein: TRPD_ROSCS
Sequence: MPIRDQIIQIVRGHDLTEEQAAEAMEEIMTGVATPAQVAALLTALHLKGETDAEIAGMARVMRAKAIPVHFDGPLLDTCGTGGDSAGTFNISTTAAFIAAGAGATVAKHGNRAMSSVCGSADVLEGLGVTIDLDAAGVARCLEQAGIGFMFAQKFHPAMRFVGPVRREIGIRTIFNALGPLSNPAQARHQTLGVADPALAEKMARALYLLGAQHALVVHGHGGLDELTLSGPNLVIEVRAGHKPRRYEVSAGDLGLTPAPREALLGGDVSTNVAIVRAILSGEERGARRDVALLNAAAALVAADYAADLREGLQQARQSLESGAALARLERLITVSSINR
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: GTCS_ANEMI
Sequence: MITAYILFTVTVGVTNSIVFYLDDHIGTRHFKKRVYCSSAWIVAWRLMEMVIFALSVYLYSRWTSKRITGPLEKITDAIQKMREGEFAQRLCFKADYELTLIQEHFNEMVAHLEKTEAEKNKLEQSKQRMLLDLSHDFKTPITTIQGYAMALQMGVVDSPEKQRRYLEMIYNKSIIVTALVEDMFQLATLDSPDLPSAEEHGRFGRTGSEIAIAYFDQFEQNKFSLDLKIPTQRVMIRMNRNLLYRALSNLLSNTLKHNPKGTKVALSLTDTHEAILLEVMDNGIGIAEELKESIFQPFVRGDKARTGEGTGLGLPSPKKRLNFMVESCCSRVNQGKQYSRSFSQRLENDLPYRLPYHRMNKFHRNANQQ
What is the function of this protein?
Member of the two-component regulatory system GtcS/GtcR which may act in the control of the transcription of the grs operon which encodes the multienzymes involved in the biosynthesis of the peptide antibiotic gramicidin S.  Probably activates GtcR by phosphorylation.
What are the official names of this protein?
Sensor protein GtcS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL11_METRJ
Sequence: MAKKITGYVKLQVPAGAANPSPPIGPALGQRGLNIMEFCKAFNAKTAQMEKGTPIPVIITAYQDRSFTFEMKQPPVTFFLKKAAGLKLGKKPASGSKTPGKGPTVGKISEAQLREIAEKKMPDLNCDTVESAVAMIRGSARAMGLEVVA
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: MGSA_HALH5
Sequence: MRIALIAHDKKKDEMVQFTIAYKDVLKDHELYATGTTGMRIMEAAQLPVKRFKSGPLGGDQQIGALVAENKFDLIIFLRDPLTAQPHEPDVTALVRLCDVQRVPLATNIGTAEILIKGLARGDFTWRELVHDEEEPRV
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: SAT4_ARATH
Sequence: MACINGENRDFSSSSSLSSLPMIVSRNFSARDDGETGDEFPFERIFPVYARGTLNPVADPVLLDFTNSSYDPIWDSIREEAKLEAEEEPVLSSFLYASILSHDCLEQALSFVLANRLQNPTLLATQLMDIFCNVMVHDRGIQSSIRLDVQAFKDRDPACLSYSSAILHLKGYLALQAYRVAHKLWKQGRKLLALALQSRVSEVFGIDIHPAARIGKGILLDHGTGVVIGETAVIGDRVSILHGVTLGGTGKETGDRHPNIGDGALLGACVTILGNIKIGAGAMVAAGSLVLKDVPSHSMVAGNPAKLIGFVDEQDPSMTMEHDATREFFQNVAVAYRETIPNGSSVSGSCRERRH
What are the official names of this protein?
Serine acetyltransferase 4, AtSAT-4, AtSERAT3;2.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_OLEA2
Sequence: MEQNEFGLIEKIVDLNRVAKVVKGGRRFSFSALVVVGDGNGSVGFGMGKAQEVPEALRKATERAKKGMVQVPLVDGTLPYEVLGAFGAGRVLLKPASKGTGIIAGGAVRAIMEAVGIHDVLAKAIGTNNPHNVLRATMAGLTSLRSAEYVSQLRGKKLEAPRK
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: AROE_SHEB9
Sequence: MTDRYAVFGNPISHSKSPFIHGQFAAPTQESLTYEAILAPVDGFEASLTAFFNAGGKGANVTVPFKEQAFALCDSISPEAKLAGAVNTLSLLADGTIRGDNTDGLGLVADLIANLGSLQDQRVLLIGAGGAARGCILPLLNAEIAQLTISNRTHTKAQLLVDIFTSVDNGAYASKVTAVEMSELAGEFDIIINSTSASLAGELPPLPAHIITTQTVCYDMMYGASVTAFNQWALSQGAAKAIDGLGMLVGQAAKSFTLWRGVEPDTQVVLTLLRDKLMAEPK
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: P102E_LUPLU
Sequence: MGIFTFEDESTTTVAPARLYKALVKDADTIIPKAVEAIQSVEIVEGNGGPGTIKKLTLIEGGETKYVLHKIEAIDEANFGYNYSIVGGIGLPDTIEKISFETKLFEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIENYLIAHPEY
What is the function of this protein?
Class II ribonuclease (RNase) (By similarity).  Binds to cytokinins (By similarity).  Interacts with melatonin (By similarity).
What are the official names of this protein?
Class 10 plant pathogenesis-related protein 2E, Llpr10.2e, Ypr-10.2e.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: OCAT1_DANRE
Sequence: METEYSKRVYQGVRVKHTVKDLLAEKRLRQTNTPRFSTSSSSSQPAFVPMPGSHVLPGYYSMRRSFLQDSELCHTVKQYSSDTYSSALGSKAFSYDHASTYPAFIDSYYTPDSYGDYRGPTSYTTSGGSLFPPSSLPTLLPTLSGESSSHLLLRDPWDQPSEDSVNQTEVLCPEAAAPVADSPSLAGPDSGSSSPYRLTSGRSGSSIPSSSQPYTLQPLEDVPYTAPSYTSASSYSCPPYMSTPGDLAVVKMTAVTSEEASGGVVSLSDTTSWAKDDGTGSWLSYETRRAF
What is the function of this protein?
Transcriptional coactivator that may regulate cell type-specific differentiation pathways.
What are the official names of this protein?
POU class 2 homeobox associating-factor 2, Protein OCA-T1.
What is the protein family that this protein belongs to?
Belongs to the POU2AF family.
Protein: ACET1_ORYSJ
Sequence: MGLGVRAAPFTYVAHALAVAAATMVLVWCIHFRGGLAFEATNKNLIFNVHPVLMLIGYIILGSEAIMVYKVLPTWKHDTTKLIHLILHAIALVFGAVGIYCAFKFHNESGIANLYSLHSWLGIGTICLYGIQWIFGFVAFFFPRASPSVRKGVLPWHILFGLFVYILALATAELGFLEKLTFLQSSGLDKYGAEAFLVNFTALIVVLFGASVVVAAVSPARVEEPHEYAPIPES
What is the function of this protein?
Two-heme-containing cytochrome.  Catalyzes ascorbate-dependent trans-membrane electron transfer by utilizing a concerted H(+)/e(-) transfer mechanism (By similarity).
What are the official names of this protein?
Probable ascorbate-specific transmembrane electron transporter 1, Cytochrome b561-1.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YIDD_BRUO2
Sequence: MGSCGGKHTGKGAPKPYSRNFTDPWRKTPGRLFGTALIRFYQITLSSLIGNSCRHLPTCSEYAYEAIARHGLWRGGWMGFFRVVRCGPFGTHGFDPVPRELSPDLKWYMPWRYWRCSASRTGK
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CCR1_MOUSE
Sequence: MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
What is the function of this protein?
Receptor for a C-C type chemokine.  Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level.  Responsible for affecting stem cell proliferation.
What are the official names of this protein?
C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HPBP1_HUMAN
Sequence: MSDEGSRGSRLPLALPPASQGCSSGGGGGGSSAGGSGNSRPPRNLQGLLQMAITAGSEEPDPPPEPMSEERRQWLQEAMSAAFRGQREEVEQMKSCLRVLSQPMPPTAGEAEQAADQQEREGALELLADLCENMDNAADFCQLSGMHLLVGRYLEAGAAGLRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVREQEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQLVALVRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLRHRCQLLQQHEEYQEELEFCEKLLQTCFSSPADDSMDR
What is the function of this protein?
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding.  Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
What are the official names of this protein?
Hsp70-binding protein 1, HspBP1, Heat shock protein-binding protein 1, Hsp70-binding protein 2, HspBP2, Hsp70-interacting protein 1, Hsp70-interacting protein 2.
Protein: AIM11_PICGU
Sequence: MSFTNLLEKYDFKLASASEEYKQRRKYQMALFMASGAATIFAARFAFKSTMARQYVPTLFQGNHQPPTSYNFTTDAAVAVGTGTVLCGSVSSMIIFGTCWMMDVSTFKEFGWRMKTVMGGYEKQKQLAQMPLDEESEIIQNGLNDILEGKYDDIE
What are the official names of this protein?
Altered inheritance of mitochondria protein 11.
What is the protein family that this protein belongs to?
Belongs to the AIM11 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CAH12_MOUSE
Sequence: MPHRSLRATVVLLLVILKKQPSSSAPLNGSKWTYVGPAGEKNWSKKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHHYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYPDFSTASDKSEGLAVLAVLIEIGSANPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPTPREMINNFRQVQKFDERLVYISFRQGLLTDTGLSLGIILSVALAGVLGISIVLAVSIWLFKRKKSKKGDNKGVIYKPAIKKEAEVHA
What is the function of this protein?
Reversible hydration of carbon dioxide.
What are the official names of this protein?
Carbonic anhydrase 12, Carbonate dehydratase XII, Carbonic anhydrase XII, CA-XII.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cell membrane.
Protein: SPC42_YEAS1
Sequence: MNGSPTPKRYSSKSSRLYDDYYNIPYQYSNPTPMNRDYNDVGSRINADKLVPEEYKRNTEFINKAVQQNKELNFKLREKQNEIFELKKIAETLRSKLEKYVDITKKLEDQNLNLQIKISDLEKKLSDANSTFKEMRFPKVKDPMVDDDPVSENYDQINVPKHRAPDATGNPRTTNKVSNTSDQDSRLKAIERTLSVLTNYVMRSEDGNNDRMSPLPSPLNTISPINNRLNFQEPKRYNPTVKVNPSDDDIMMYESAELKRVEEEIEELKRKILVRKKHDLRKLSLNNQLQELQSMMDGDDNIKLDNVSKHNHATHRHSSQSSRDYSPSSDACLECSNDLYEKNRVKPENNMSETFATPTPNNR
What is the function of this protein?
Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.
What are the official names of this protein?
Spindle pole body component SPC42.
What is the protein family that this protein belongs to?
Belongs to the SPC42 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: UBIB_PSEA7
Sequence: MKLLAFRRLLRIQRVVVRYRLDDLILELPMLPWWLRLLGAALPWRWLPRRKLELTRGARLRLALQDLGPIFIKFGQILSTRRDLLPDDIANELAWLQDKVPPFPPELAVKRIEEQLGAKIEQVFARFEREPLASASVAQVHAARLKSGEEVVVKVIRPNLEPVIRSDIAWLFILARLAERVSSEARRLHPVEVVSDYEKTIVDELDLLREAANASQLRRNFEGSPLLYVPQVYWDWCRPKVLVMERIYGIPVTDLETLRDQRTDFKALAERGVEIFFTQVFRDSFFHADMHPGNIFVSTRAPWSPQYIAVDCGIVGSLTDEDQDYLARNLIAFFKRDYRKVAQLHIDSGWVPAETKVNDFEAAIRTVCEPIFEKPLKDISFGQVLLRLFQTARRFNMEIQPQLVLLQKTLLNIEGLGRQLYPELDLWATAQPFLERWMRERVSPKQLLRNFQQQVEQVPHLSQMARDTLERLSQPHAHNAPPPEWKSSRHDWLGRLVGAVLLVGAAEVGLGQQLEAWPAWVMLAGGVFLILRR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PAND_CORJK
Sequence: MLRTMLKSKIHRATVTQADLHYVGSCTIDADLMEAADILEGEQIDIVDIDNGNRLTTYAITGDRGTGVIGINGAAARLISPGDLVIIIGYAQYSEEDLKNYASRVVFVDGNNKQVELGGDPAQVPDGSGLKNPRHPEA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WDR70_XENTR
Sequence: MDENEDSSIAATMGFSGFGKKARTFDLEAMFEQTRRTAVERSKKTLEAREKEEQISNKSPVMKDVPSSSRQKNTDTSSSSSGSEDSSDDELIGPPVPSNLTGDHGDELIGPPLPSGYKDSDDEDEEQHEDDDNPVKGIPDSHEITLQHGTKTVSALGLDPSGARLVTGGFDYDVRFWDFAGMDASLQAFRSLQPCECHQIKSLQYSNTGDVILVVAGNSQAKVLDRDGFPVMECVKGDQYIVDMANTKGHTAMLNGGCWHPKIKEEFMTCSNDGTVRTWDVSNEKKHKGVFKPRSMQGKRVIPTCCTYSRDGKFIAAGCQDGSIQIWDRNMSVHTKFHCRQAHTPGTDTSCVTFSYAGNILATRGGDDTLKTWDIRKFKNPLNVASGLANYFPMTDCCFSPDDKLLITGTSVKRGGGDGKLMFFDVGTFQKVYEIQVTEASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNRSQRGAKLCVVKTQRKARQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPVKSHKPEPPVAGPGRGGRVGTHGGTLSSFIVKNIALDKTDDSNPREAILRHAKDAEKNPYWVAPAYSKTQPNTVFAEVESDEEETDNEPEWKKRKI
What are the official names of this protein?
WD repeat-containing protein 70.
What is the protein family that this protein belongs to?
Belongs to the WD repeat GAD-1 family.
Protein: IFD1_CAEEL
Sequence: MSKLNPRVAHNPVLSRIIESGRTNLPSGITSAGSLSAYAQAAAVTIRDNRDREKREIADLNNRLARYVEKVRFLEAQNRVLENDIGLFRQAAHIHTGKVRDYYDAEKTSLATLVREQEAKVSSAKQNIRKLEPEITTAIRTLASSLEHRQRVRSDKKEQLKHLSDLESETAYIKRLINDCDDEKSHLKTEISRIRGEIKRILALRDKERNGFSRSQTAAQDLLKKLNATISTHEIAIREEINKARRDSTDKNREFFHRELHMSMKEIRDQFESDSKKARKTWEEWYKKKITEIKKRSEKFSLTQNQAREEVLRIRSLLNELRTKISDADSMTQALSKRIEDMKFREDEELRMFEQSLTEKELAVTRMRDECAKLSVELETLVENQINLRSEIAHYRKLMEQAENLRTSYQSDFVIDTPSPLMRTSSHHYGSSYSLNVRDTHNKTVHHDNYDISSASTINTQQFRSYGKGDVKIIEHKDESIVIENSNSYKSKDLSNWKINHYVNGALTGTFILPVATHIHPHEKISIHSLKSPNLMDDIVATQIYSFDFSKNTKTVLLDDVDDEVGWYAHVSYSH
What is the function of this protein?
Cytoplasmic intermediate filaments provide mechanical strength to cells.  Not essential protein.
What are the official names of this protein?
Intermediate filament protein ifd-1, Cel IF D1, Intermediate filament protein D1, IF-D1.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARV1_HUMAN
Sequence: MGNGGRSGLQQGKGNVDGVAATPTAASASCQYRCIECNQEAKELYRDYNHGVLKITICKSCQKPVDKYIEYDPVIILINAILCKAQAYRHILFNTQINIHGKLCIFCLLCEAYLRWWQLQDSNQNTAPDDLIRYAKEWDFYRMFAIAALEQTAYFIGIFTFLWVERPMTAKKKPNFILLLKALLLSSYGKLLLIPAVIWEHDYTSVCLKLIKVFVLTSNFQAIRVTLNINRKLSFLAVLSGLLLESIMVYFFQSMEWDVGSDYAIFKSQDF
What is the function of this protein?
Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892).  Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892).
What are the official names of this protein?
Protein ARV1, hARV1.
What is the protein family that this protein belongs to?
Belongs to the ARV1 family.
Protein: Y9609_DICDI
Sequence: MNKIKVFKKNFFFEKIKNKKNNIEIKKSTNDSTSNTCTDIKNNIIIENKINEENIENNNNINIGNNSVNNNNINNNNNSINNNNNNNNKNKNKNNNSYIPMIQYSNIHCIDWSSLISVDKLDLGSSNIFLIATFLNNKCEYNQVLLKSSTTIVQEVYASVLESILKLPIPEMRLLEYSNDEYIQMSRSLLTISSKTNKSLYDYIKLELLKSFFLIMEYAPNGKSFKDLDYKEYFSGYGGEKKLNQLGQVIAFDIFCNNSDRLPLIWDNVSSHFSNILFYDIPNRNGWYISLMNSNVTCINNSSFTIGYRKYITRVKSILYALFKRPNIESNQIKKMRESISKSYKINLSSSCGISIQRGIIQGVQLIISRISISILSDTKEKLRHLVKVDSTTNAWKKGLDSIHLPFLSDLLDTMVLFY
What are the official names of this protein?
Putative actin-fragmin kinase DDB_G0279609.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AFK Ser/Thr protein kinase family.
Protein: RL15E_SULAC
Sequence: MTLSMYHYIEQTWQNKDWRRSILRKRLIEWRRQPAITRIDRPTRLNRARALGYKAKQGFVMVRVRVRRGGLNKPRPNSGRRPKRMGVYGYGPSKGYRWIAEERAARKFPNLEVLGSYYVAEDGMYKYYEVIMVDYSHPVIRSDPELKWLQDSVNRKRVFRGLTSAGQKSRGLTKSRGLKGTVQRKWKKKQKERQLKRRHEATRYYRLQHSGRKIPGK
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: NUDK_SHIDS
Sequence: MTQQITLIKDKILSDNYFTLHNITYDLTRKDGEVIRHKREVYDRGNGATILLYNAKKKTVVLIRQFRVATWVNGNESGQLIETCAGLLDNDEPEVCIRKEAIEETGYEVGEVRKLFELYMSPGGVTELIHFFIAEYSDNQRANAGGGVEDEDIEVLELPFSQALEMIKTGEIRDGKTVLLLNYLQMSHLID
What is the function of this protein?
Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.
What are the official names of this protein?
GDP-mannose pyrophosphatase, GDP-mannose hydrolase, GDPMK.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudK subfamily.
Protein: Y350_MYCGE
Sequence: MKISPDQKDKKSLFKKHFAYLKLTEKELNDPKIQTLLEVAWNHFDQCRKIKERRCSNKGDIHLQAVREWLPWEFNANQLKKNSTKETTQVSENEFMGNVMLMQTICPKLVNKANWFDLTYERFIVTKPNWFKYMDLIPMIQNLPVTPSDKNSFGYAYKKISNLFETEKKTKKRIFFFNLQKNNINNMAACMLTCEIAKKNIKVALIYCEEFVSRYDKSYWKVDDDLNLLDEAKVIIFIGLGQESFHNKNYILFMTRLFINCFLKRKDVFFFSTTYSDGNGLIQTFKNQIISSANWVKHFFEQLNDLLMINI
What are the official names of this protein?
Uncharacterized protein MG350.
Protein: ASTL_MOUSE
Sequence: MGIMGSLWPWILTMLSLLGLSMGAPSASRCSGVCSTSVPEGFTPEGSPVFQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERFTCIRFVAYHGQRDFVSILPMAGCFSGVGRSGGMQVVSLAPTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVMHYGRFAFSWRGQPTIIPLWTSSVHIGQRWNLSTSDITRVCRLYNCSRSVPDSHGRGFEAQSDGSSLTPASISRLQRLLEALSEESGSSAPSGSRTGGQSIAGLGNSQQGWEHPPQSTFSVGALARPPQMLADASKSGPGAGADSLSLEQFQLAQAPTVPLALFPEARDKPAPIQDAFERLAPLPGGCAPGSHIREVPRD
What is the function of this protein?
Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization.  Plays a role in the polyspermy inhibition.  Probably acts as a protease for the post-fertilization cleavage of ZP2.  Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
What are the official names of this protein?
Astacin-like metalloendopeptidase, Oocyte astacin, Ovastacin, Sperm acrosomal SLLP1-binding protein.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Note=Probably exocytosed from cortical granules during post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages. Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS).
Protein: TYOBP_BOVIN
Sequence: MEGLRPSDRLLSLLLTVGGLSLVLAQSECNCSSVSPGVLAGIVLGDLMLTLLIALAVYYLGRLVPRGRGATEVTRKQHIPETESPYQELQGQRTDVYSDLNTQRPYYK
What is the function of this protein?
Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity).  TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity).  Also has an inhibitory role in some cells (By similarity).  Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity).  Also mediates cell activation through association with activating receptors of the CD200R family (By similarity).  Required for neutrophil activation mediated by integrin (By similarity).  Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity).  Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity).  Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity).  Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity).  Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity).  Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity).  In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity).  Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity).  Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity).  Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allosimulatory ability (By similarity).  Negatively regulates B cell proliferation (By similarity).  Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity).  Positively regulates multinucleation during osteoclast development (By similarity).
What are the official names of this protein?
TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12.
What is the protein family that this protein belongs to?
Belongs to the TYROBP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ATPG_ALTMD
Sequence: MASGKEIKGKIGSIKNTQKITSAMEMVAASKMKKAQERMASGRPYAQNMLKVIGHIANGNLEYRHPYLEEREVKRVGYIVISTDRGLCGGLNTNEFKLVTQDVKKWREQGVEVDFAALGSKACSFFNRFGGKLLAAESGLGDKPSVSDVVGVVRVMLKAYDEGQIDRVFLVFNDFVNTMTQKPVINQLLPLPKSEDEEYQHRWDYIYEPDPKEILEALMVRYIESQVYQGVVENAASEQAARMVAMKAATDNAGNLIDELQLVYNKARQAAITQEISEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.