PharMolix/UniProtQA huggingface dataset:
Protein: PSB8_HUMAN
Sequence: MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.  This subunit is involved in antigen processing to generate class I binding peptides.  Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.  Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119).  Acts as a major component of interferon gamma-induced sensitivity.  Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1.  May be involved in the inflammatory response pathway.  In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency.  Required for the differentiation of preadipocytes into adipocytes.
What are the official names of this protein?
Proteasome subunit beta type-8, Low molecular mass protein 7, Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13, Proteasome component C13, Proteasome subunit beta-5i, Really interesting new gene 10 protein.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
Protein: GPMI_LEGPL
Sequence: MSHNAPLVLMILDGWGYNENDRYNAIAKANTPQWDEWWQTCPHILLKASGLPVGLPDEQMGNSEVGHMHIGAGRVIQQDFTRINEAINNGKFAKNAVFHEVIDQLKKTEKSLHIMGLLSPGGVHSHEQHLFALLALCNQKKFRSVHLHLFLDGRDTPPQSALDSLKCLNEELAKHPVATINSICGRYYAMDRDKRWQRVEPVYNLLTQGKSERQFPDAETAIHFYYKNKISDEFVPPTLIGKEHSIQDGDAVLFFNFRADRARQLTSTFLDPSFKGFERKTLPKLSYFVSMTQYDKNLFTTTAFPPVPLNNTLGEVLSSHGLSQLRIAETEKYAHVTFFFNGGCESVFTNEERIMVPSPQVATYDLQPEMSAHELTKTLIAAINSQDYHVIICNYANADMVGHTGNFEATVQAIECLDQCMQQVWQALKNNGGKLLITADHGNAEEMFSEATNQAHTAHTSEPVPFLYVGGGWHFTHSEGSLIDIAPSLLALLGITPPPEMTGRILLEKNHAHA
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: RNH2_EHRRG
Sequence: MHNYLDNIMPDFSIENEILKLKNNKECIIVGVDEVGYGSLAGPVVSAAVFFPNYNNETTQDINDSKKLTPKTRQKIYNKIITRVKWSIGFAHIFEIDEYNILNATHIAMKRALTGLNAHIDIDYVIIDGNKIPNIPWNAQAIIGGDTISTSIAAASIIAKVTRDRLMETLHIQYPQYNWNKNKGYGTKDHITSLYKYGKTIHHRNTFTPISKISYMFKNS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UTP25_BOTFB
Sequence: MAFGQRNTSRGGRGGGGGGSSFRGRGGSRGGPRGRGGMRGGRGRGRGRPVFDSARLAQKEEDEESDSESEEPSQDEASEEESSDDDDDDEPVPAVKSYTALMQSFTRDSAPQAKRRKLNVDKEEKEDEDADLMDEDTNEADLVEEEEEGPETATDGILEDDEEDKADPFEAHFANPDDNILSRRLQHLEKGQWALRMSSLAKVGTAITSIPGDGEPRAMKAMTIGSPEGLKLKQKLANVIKKQRPTFDALEKSIAPLVFGYQDLLFTERNTSNAESLRRLTCLHAVNHVFKTRDRVIKNNSRLAREDSSDDLELRDQGFTRPKVLMLLPTRESCVRMVDMITSLCEPEQQENRKRFNDSFVDKEENYSTDKPEDFRELFAGNDDDMFRLGLKFTRKTIKYFSQFYNSDIIFASPLGLRMAIGDEDAKKVDHDFLSSIEIVIVDQADALLMQNWEHVEFIFDHLNLQPKEAHGCDFSRVRSWYLDNNAKYFRQNIALAGFNTPELQTMFYTQSQNWEGKAKVSSTYPGAIQELGLKVKQTFSRIDTESIASDPQSRFEYFTSAIIPTLTRRSKDSSGTLLFIPSYMDFVKVRNYFSTSATTSSLSFGSISEYTTPKEVARARSHFFSGRHNVLLYTERAHHFRRYQIRGVKKVIMYGIPENPIFYKEIVAGYLGRSVREGDLEPGNGSLRAVFSKWDSMKLERIAGTERVNKMIKEKGDTFDFL
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CBIZ_HALSA
Sequence: MFETTLHDGVLELAAPGARWLSTGWNGGDTRADRAYSITVPDDWAPDSTHEYVTDRLAAAGFAPRDDAPVLLTGVAQEHARIARCGPVAVAATAGLSNPAALPMDPDGGTLPDAKRAPPGTVNLVAATTRALDDAALSNLVAVAAEAKAATLLATAGFPGTTSDAVVVACDPGGETAPYSGSATPVGAATRACVREAVRASLDSRDAASPDSVESAAHGTTTDVQAAVFRP
What is the function of this protein?
Converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route.
What are the official names of this protein?
Adenosylcobinamide amidohydrolase, AdoCbi hydrolase.
What is the protein family that this protein belongs to?
Belongs to the CbiZ family.
Protein: KGUA_BURPS
Sequence: MTDSNRDGAAAHSLHAGVYPGNLFMVVAPSGAGKSTLVNALLSKDPEIRLSISYTTRKPRPGEQDGQHYHFTTVEDFRERHARHEFLESAEVHGNYYGTSRVWIEEQMKIGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLAALEERLKKRGQDEPNVITRRLLAAGSEIAHAAEAQYVVINETFEHALAELECIVAATRLRFTSQYARHAELFVELGIHLPHAE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CKI4_ORYSJ
Sequence: MDIVPVVALCCCLVLLPSWAYGLGSMASIAVSYGEDGPVFCGLNSDGSHLVTCFGADASVVYGAPSRIPFVGVTAGDGFACGLLLDTNQPYCWGSNSYVKIGVPQPMVEGAMYSELSAGDNHLCALRTSVKGFHSVNGDTSVIDCWGYNMTATHTVTGAVSAISAGSVFNCGLFARNRTVFCWGDESVSGVIGLAPRNVRFQSIGAGGYHVCGVLENAQVFCWGRSLEMQQMSTPSSTDDGDVNIVPMDAMVSVVGGRFHACGIRSLDHQVACWGFTLQNSTLAPKGLRVYAIVAGDYFTCGVPAETSLKPMCWGHSGPLALPMAVSPGICVSDSCSHGYYEYANHGEVGSGSKTCKPANSRLCLPCSVGCPDDSYESSPCNATADRVCQFDCSKCASDECVSFCLSQKRTKNRKFMAFQLRIFVAEIAFAVILVFSVTAIACLYVRYKLRHCQCSKNELRLAKNTTYSFRKDNMKIQPDVEDLKIRRAQEFSYEELEQATGGFSEDSQVGKGSFSCVFKGILRDGTVVAVKRAIKASDVKKSSKEFHTELDLLSRLNHAHLLNLLGYCEDGSERLLVYEFMAHGSLYQHLHGKDPNLKKRLNWARRVTIAVQAARGIEYLHGYACPPVIHRDIKSSNILIDEDHNARVADFGLSILGPADSGTPLSELPAGTLGYLDPEYYRLHYLTTKSDVYSFGVVLLEILSGRKAIDMQFEEGNIVEWAVPLIKAGDISALLDPVLSPPSDLEALKKIAAVACKCVRMRAKDRPSMDKVTTALERALALLMGSPCIEQPILPTEVVLGSSRMHKKVSQRSSNHSCSENDLVDGDDQRIEYRAPSWITFPSVTSSQRRKSSASEADMDGRTTTDGRNVGSSIGDGLRSLEEEISPASPQENLYLQHNF
What is the function of this protein?
Receptor protein kinase (PubMed:22899082).  Could play a role in a differentiation signal (By similarity).  Controls formative cell division in meristems (By similarity).  Regulates epidermal cell differentiation in many organs (PubMed:22332708, PubMed:22899082).  During floral organogenesis, required to maintain the interlocking of the palea and lemma, and fertility (PubMed:22332708).  Triggers culm elongation (PubMed:22899082).
What are the official names of this protein?
Serine/threonine-protein kinase-like protein CR4, Protein CRINKLY 4, OsCR4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single- pass type I membrane protein. Note=Also localized into protein export bodies.
Protein: YRAN_SHIDS
Sequence: MATVPTRSGSPRQLTTKQTGDAWEVQARRWLEGKGLRFVAANVNERGGEIDLIMREGRTTVFVEVRYRRSALYGGAAASVTRSKQHKLLQTARLWLARHNGSFDTVDCRFDVVAFTGNEVEWIKDAFNDHS
What are the official names of this protein?
UPF0102 protein YraN.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: RUVB_STAAS
Sequence: MNERMVDQSMHSEETDFELSLRPTRLRQYIGQNSIKSNLEVFIKAAKLRHEPLDHVLLFGPPGLGKTTLSNIIANEMEVNIRTVSGPSLERPGDLAAILSGLQPGDVLFIDEIHRLSSVVEEVLYPAMEDFFLDIIIGKGDEARSIRIDLPPFTLVGATTRAGSLTGPLRDRFGVHLRLEYYNESDLKEIIIRTAEVLGTGIDEESAIELAKRSRGTPRVANRLLKRVRDFQQVNEDEQIYIETTKHALGLLQVDQHGLDYIDHKMMNCIIKQYNGGPVGLDTIAVTIGEERITIEDVYEPFLIQKGFLERTPRGRKATPLAYEHFAKSNEERG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RL34_CALBD
Sequence: MKRTYQPHNKRRKRTHGFLVRMRTKGGRKVLKRRRLKGRKRLAV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: HTF_BLAGE
Sequence: QVNFSPGWGT
What is the function of this protein?
Hypertrehalosaemic factors are neuropeptides that elevate the level of trehalose in the hemolymph (trehalose is the major carbohydrate in the hemolymph of insects).
What are the official names of this protein?
Hypertrehalosaemic hormone, HTH, Adipokinetic hormone 1, BlaGe-AKH-1, Hypertrehalosaemic neuropeptide.
What is the protein family that this protein belongs to?
Belongs to the AKH/HRTH/RPCH family.
What are the subcellular locations of this protein?
Secreted.
Protein: LYSC_PELSI
Sequence: GKIYEQCELAREFKRHGMDGYHGYSLGDWVCTAKHESNFNTAATNYNRGDQSTDYGILQINSRWWCNDGKTPKAKNACGIECSELLKADITAAVNCAKRIVRDPNGMGAWVAWTKYCKGKDVSQWIKGCKL
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.  Has strong bacteriolytic activity against M. luteus and V. cholerae, weak bacteriolytic activity against P. aeruginosa and no activity against A. hydrophila.
What are the official names of this protein?
Lysozyme C, 1,4-beta-N-acetylmuramidase C, Softshell turtle lysozyme C, SSTL.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GPDA_TREPS
Sequence: MASIAILGGGAWGTALAASLTVNGHTVMLWARRRQTCDAINARNENVQYLPGITLPAALCASPDMAYVCAGADLIVLAVPSCYLAEVAALMNTTPRFQRLRTAAVGQEYPLIGILTKGFIPDQEGMPHLITDALGALLPSGAHGQLVYISGPSHAQEVAQGKVTGLIAASQNPMAAIRVRELLRSKRVQVYSSLDVVGVQVCAAVKNVIAIAFGLLDAMAEHSEAFGDNTESMLLAAGLNEIQTIGKQLGSTHPETFTSLAGIGDLDVTCRSAYGRNRRFGRDIVHKGILDSFSGIQDLVSRLPEVGYLAEGVVACMHVQRLAERDRLKVPICAGLYAILNREKGADTFMQEILGW
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMGN5_RAT
Sequence: MPKRKAAGDASQEPKRRSARLSAMPVPFTPELKPKRASTSRKTKTTNVVEESKDAGATTIPETKPEVVKGECNMENAENGEAKIIEAPISKMETEEVKEQINEDTEGDGGEKKEAVVTKGKNDELEANIQDVEKDEDEKEHEDTGEEGEDGEREGGLKEKPDVAEIEDAKEAKDDEEKEDKEKEDDKGGDGKKEEEKDDEGEAETEEEVKEQQKEETEGDDGKCKVEENKEGRKESQHEEEGKEELHEEDGKEDLHEEDGKEDLHEEDGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEEGKEDLHEEDGKEGQHEEEGKEDLHEEEGKEDLHEEDGKEGQHEEDGKKKADGNEDRKEEEEQEAATEGNDENKVEVEEEADNKDFKEDGEKGEPVSTV
What is the function of this protein?
Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.
What are the official names of this protein?
High mobility group nucleosome-binding domain-containing protein 5, Nucleosome-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the HMGN family.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.
Protein: RSMG_PROM3
Sequence: MSNQACFSNPGPELWNALGWHPSSEQLEQMIALQALLRQWNARVNLTRLVEGGDYWILQVFDSLWPLQSELQNAQQPRRCIDIGSGGGFPGLVLAIALPGASITLVDSVGRKTAALKAMAAKLGLTSRVTVRSERAELTGQDHCCRGLFDLAMARAVSTAPVVAEYLVPLLKPSGEALLFRGHWSPNDAKDLAKALRFLQADLIKMERRELPDNRGVRHQLRLRATLPCPATFPRPIGVPAKNPLGS
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HFLX_CALS4
Sequence: MQKIEYIIITKLWVGDCMEELARDKERAILVAIISSPEDEETLNELKELAVTAGAEVIGILTQKKKGINKAHYIGKGKLEELKMFVENQQADLVIVNDELTGTQIKNLEDALGVKIVDRTNLILDIFAKRARSKEGMLQVELAQLKYRLPRLVGLGGQLSRLGGGIGTRGPGETKLEVDRRHIRNRIKAIEEKLEELEKHRNLQRQRRKKNQIPVVAIVGYTNAGKSTLLNALTGADAYVEDKLFATLDPTARKLVLPSGREVILTDTVGFIRKLPHDLVEAFKSTLEEVKYADLLLHVIDVTSPDMDEKIKVVEKVLSDLGAIETPRINVYNKIDLLEIVPSGNNRDIYISAKNKIGLDRLLEAIERELFKETEVVSFLFPYEKTREYNYLKERGKVIEEDFDEKGISVKAEVTCEIKERLRNFIIS
What is the function of this protein?
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
What are the official names of this protein?
GTPase HflX, GTP-binding protein HflX.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=May associate with membranes.
Protein: RN207_CAEEL
Sequence: MEENPLQCTICKNEFEEPILLSCQHTTCRKCSTGSPSCKSCSPIPSTSRSHTPHPDKLAAFLLDASKEEMEECANCEQISLPMFYCETCQQSLCLVCRNVTHQARMFSSHKIISSDERSKVYSSSLCKDHNEPYILYCSDVRKLVCIQCFNGRPLEERHSFISIEQGHRLCLERIEQSAAKLRFYQSERQEELNVRQRVLDENASNFDDARASLYQLCQQIIDTVMTTRETLAKELVKQQEQSDEQCKRQIKEIEAVMGPVRLCLFSAQILCTTASKLDVLQLCPQLQKRIGVLLDKTIDKLPVSSTPDSIEVRSDLAKALEPFLGMSAAWCPISVSREGSSSNSYKRGSGSHKAISMLSKFQATIDLAGAFGELFGKVEHPLRQLVTALSSTSQQVLETQRDLTIRRCIIEKEDVEKLVKTCKKIEAGLGMHSAALDGMQSEMQEIWQEQLDRVRRQQIIYREKVEEILNLRETARQILTAAKQLVPYVSCILNMNAMIDPKRCHPPDPAPMESICLEITGIEPNSQNRILAIEKEEENRRLNQEAKKKEELAGQSAVMKTLKHGKIKRKEMNRMMLNTNRERSPGGTDTALTSPCIRRLTTALKEETASELDAEEFLDEIFELSGEQYDEVVDGTLTEEDRCSSALLLSMEISSDSISPLPSLEQLLGRIPLASRVTSNIGFSRGAMLQSLNDVFALQKPPTPENISVSEERNVLASAVRNAEKRKSGAGLPTNSDKDEVIEKEEIEKETEKEKKKVIRRRVKKVSEPSEEEVTTFTFNAPPDCPFVPQEIFESDEKLGTFEAKERVLQSLKQKMNQKTE
What are the official names of this protein?
Probable RING finger protein 207 homolog.
Protein: MIAA_SODGM
Sequence: MTEPTFPRRPQAIFLMGPTASGKTVLAMALHQHLPVEIISVDSALIYRGMDIGTAKPGADELARAPHRLIDIRDPAEAYSAADFRRDALKEMAEITEAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEREAETVGWQALHRQLQQIDPIAANRIHPNDPQRLLRALEVFFVSGNTLTELTKISGEALAYRVHQFAIVPLDRALLHQRIAQRFHQMLAAGFEHEVSTLFARGDLHREMPSIRCVGYRQMWSYLADETDYDDMVFRGICATRQLAKRQMTWLRGWHDVHWLDSDEPAALDRVLQVVSA
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: ACCA_STRZJ
Sequence: MNIAKIVREAREQSRLTTLDFATGIFDEFIQLHGDRSFRDDGAVVGGIGWLGDQAVTVVGIQKGKSLQDNLKRNFGQPHPEGYRKALRLMKQAEKFGRPVVTFINTAGAYPGVGAEERGQGEAIARNLMEMSDLKVPIIAIIIGEGGSGGALALAVADRVWMLENSIYAILSPEGFASILWKDGTRAMEAAELMKITSHELLEMDVVDKVISEVGLSSKELIKSVKKELQTELARLSQKPLEELLEERYQRFRKY
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABHGA_HUMAN
Sequence: MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL
What is the function of this protein?
Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity).  LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity).  Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914).  Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914).
What are the official names of this protein?
Phosphatidylserine lipase ABHD16A, Alpha/beta hydrolase domain-containing protein 16A, Abhydrolase domain-containing protein 16A, HLA-B-associated transcript 5, hBAT5, Monoacylglycerol lipase ABHD16A, Protein G5.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. ABHD16 family.
Protein: IMPI_GALME
Sequence: MKCLLYLCLWCYCVLVSSSIVLICNGGHEYYECGGACDNVCADLHIQNKTNCPIINIRCNDKCYCEDGYARDVNGKCIPIKDCPKIRSRRSIGIPVDKKCCTGPNEHYDEEKVSCPPETCISLVAKFSCIDSPPPSPGCSCNSGYLRLNLTSPCIPICDCPQMQHSPDCQ
What is the function of this protein?
Inhibits thermolysin, bacillolysin and pseudolysin, B. polymyxa metalloprotease and human MMP1 and MMP3.  No activity on trypsin or cysteine protease papain.
What are the official names of this protein?
Inducible metalloproteinase inhibitor protein.
Protein: MANF_CAEEL
Sequence: MSRLVLLISLVIVVASAAAPQCEVCKKVLDDVMAKVPAGDKSKPDAIGKVIREHCETTRNKENKFCFYIGALPESATSIMNEVTKPLSWSMPTEKVCLEKLKGKDAQICELKYDKPLDWKTIDLKKMRVKELKNILGEWGEVCKGCTEKAELIKRIEELKPKYVKEEL
What is the function of this protein?
Inhibits endoplasmic reticulum (ER) stress response (By similarity).  Retained in the ER under normal conditions and is up-regulated and secreted by the ER in response to ER stress and hypoxia (By similarity).  Following secretion by the ER, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PubMed:29497057).  Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions (By similarity).  Has a neuroprotective role, ensuring survival of dopaminergic neurons during normal growth (PubMed:30147641).
What are the official names of this protein?
Mesencephalic astrocyte-derived neurotrophic factor homolog, ARMET-like protein, MANF/CDNF-like protein.
What is the protein family that this protein belongs to?
Belongs to the ARMET family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum lumen. Note=Retained in the endoplasmic reticulum (ER) under normal conditions. Up-regulated and secreted by the ER in response to ER stress.
Protein: RPOZ_TRIL1
Sequence: MARVTVEDCLEKVDNRFMLVMMASKRVKQLYKGAKPLIDPKNNRHVVTSLREIAAGKLSAELSSKRSA
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: CYLC1_HUMAN
Sequence: MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRYAPLPEAPWIHKLL
What is the function of this protein?
Possible architectural role during spermatogenesis.  May be involved in spermatid differentiation.
What are the official names of this protein?
Cylicin-1, Cylicin I, Multiple-band polypeptide I.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.
Protein: PDUB_LIMRD
Sequence: MNDFLNSTSTVPEFVGASEIGDTIGMVIPRVDQQLLDKLHVTKQYKTLGILSDRTGAGPQIMAMDEGIKATNMECIDVEWPRDTKGGGGHGCLIIIGGDDPADARQAIRVALDNLHRTFGDVYNAKAGHLELQFTARAAGAAHLGLGAVEGKAFGLICGCPSGIGVVMGDKALKTAGVEPLNFTSPSHGTSFSNEGCLTITGDSGAVRQAVMAGREVGLKLLSQFGEEPVNDFPSYIK
What is the function of this protein?
One of the major shell proteins of the bacterial microcompartment (BMC) dedicated to 1,2-propanediol (1,2-PD) degradation (By similarity).  Probably involved in a propanediol fermentation/reuterin formation pathway (Probable).
What are the official names of this protein?
Bacterial microcompartment shell protein PduB, Bacterial microcompartment protein homotrimer, BMC-T, Propanediol utilization protein PduB.
What is the protein family that this protein belongs to?
Belongs to the EutL/PduB family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: RS10_SYNS9
Sequence: MSTAIAQQKIRIRLKAFDRRMLDLSCDKIIETADTTAASAIGPIPLPTKRKIYCVLRSPHVDKDSREHFETRTHRRIIDIYSPSAKTIDALMKLDLPSGVDIEVKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.