PharMolix/UniProtQA huggingface dataset:
Protein: DPO3A_STAAW
Sequence: MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVDALAITDTNVLYGFPKFYDACIANNIKPIFGMTIYVTNGLNTVETVVLAKNNDGLKDLYQLSSEIKMNALEHVSFELLKRFSNNMIIIFKKVGDQHRDIVQVFETHNDTYMDHLSISIQGRKHVWIQNVCYQTRQDADTISALAAIRDNTKLDLIHDQEDFGAHFLTEKEINQLDINQEYLTQVDVIAQKCDAELKYHQSLLPQYETPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRRERVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDDQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVDERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDHRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
What is the function of this protein?
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.  The alpha chain is the DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase III subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHAB_BACTN
Sequence: MKQNFFAVDLGATSGRTILGSFIEGGLNLEEINRFPNHLIEVGGHFYWDIYALYRHIIDGLKLVAHRGESIASIGIDTWGVDFVLLGKDGNLLRQPYAYRDPHTVGAPEAFFSRISRSEVYGKTGIQVMNFNSLFQLDTLRRNHDSALEAADKVLFMPDALSYMLTGKMVTEYTIASTAQLVNAHTQRLEPELLKAVGLQEENFGRFVFPGEKIGTLTEEVQKITGLGAIPVIAVAGHDTGSAVAAVPALDRNFAYLSSGTWSLMGVETDAPVITAETEALNFTNEGGVEGTIRLLKNICGMWLLERCRLNWGDTSYPELITEADSCEPFRSLINPDDDCFANPADMEQAIREYCRTTGQPVPEQRGQIVRCIFESLALRYRQVLENLRALSPRPIETLHVIGGGSRNDLLNQFTANAIGIPVVAGPSEATAIGNVMIQAMTVGEATDVAGMRQLISRSIPLKTYHPQDMAAWDAAYIHFKNCVR
What is the function of this protein?
Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose).  Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.
What are the official names of this protein?
Rhamnulokinase, RhaB, ATP:L-rhamnulose phosphotransferase, L-rhamnulose 1-kinase, Rhamnulose kinase.
What is the protein family that this protein belongs to?
Belongs to the rhamnulokinase family.
Protein: CHY2_PAGMA
Sequence: FFGWLIRGAIHAGKAIHGLIHRRRH
What is the function of this protein?
Has antibacterial activity against Gram-positive bacteria B. subtilis ATCC 6633, L. garvieae ATCC 49156 and S. iniae F-8502, and Gram-negative bacteria E. coli WT-2, V. anguillarum ATCC 19264, V. penaeicida KHA, V. harveyi ATCC 14126, V. vulnificus ATCC 33148 and A. salmonicida NCMB 1102.  Has hemolytic activity against human red blood cells.  Seems to disrupt the membranes by adopting an alpha helical conformation.  May play a significant role in innate host defense.
What are the official names of this protein?
Chrysophsin-2.
What is the protein family that this protein belongs to?
Belongs to the pleurocidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y384_ARCFU
Sequence: MRWSIIFTALLLTLCISPPAEELSREEYCSKVWRYDYECALNYILNDEEVQKVAAVAEKLKGVDCKDTAWKILEWEDENLVYDVEKASLPPPQIVVRGKEVEVYDTGRYIQTPSETIMLRKGICTDYAFLTLALLKYNGCKGYLVNVTFENDDVGHVAAAIAVNGTYFILDQHLPPFDPQGYFIKWLRDGKRIEKAEIIDNNTTIPLNLSIGYVASDRDAKSLESRIRQYFKGTGIREDPRLNGEKLPLGYREGYTLKLSLEMAEYYHPEFERQYAEHIYKLLEESIEGRFKAFNLHLSIKGDVMEIVLYLAR
What are the official names of this protein?
UPF0252 protein AF_0384.
What is the protein family that this protein belongs to?
Belongs to the UPF0252 family.
Protein: MURC_LACP3
Sequence: MTEATYYFIGIKGSGMSALALVLHDLGHQVLGSDITQYTFTQKGLAAAGIKMLPFDPANLKPGYTVIAGNSFTDDHPEIKRAKELGLTIYRYHEFLGKLIEGYTSIGVAGAHGKTSTTGLLAHTLSGVAKTSYLIGDGTGKGIPDSKFFVFEADEYRRHFLAYHPDYMIMTNIDFDHPDYYTGFEDVYDAFETEANQVKKAIVAWGDDPWLRKLKAKVPVYYYGISDRDDFQARNVDRDTKGSSFDAYFHDQLIGHFFVPLFGEHSVLNALAVVAVAHMEKLDAKLIARELGNFSGVKRRFAEKDLKDMIIVDDYAHHPNEIKATLDAARQKYPDKAIIAVFQPHTFSRTQAYEPQYVQVLSQADQTFLTPIFSSAREKTGKIRSEDITAQIKGAAVIHQEDMKPLLQYHNAVVVFMGAGDIQKYEKAYETILAEE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPRA1_RAT
Sequence: MASLQEANGSTAWPPPTASNISEPHQCLLLLYEDIGSSRVRYWDLLLLIPNVLFFIFLLWKLPLARAKIRVTSSPIFITFYILVFVVALVGIARAVVSMTVSASDAATVADKILWEITRFFLLAIELSVIILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDSHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVILPKTPLKERVSLPSRRSFYVYAGILATLNLLQGLGSALLCANIIVGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDEAEEPDMHLPQPYAVARREGIESAGPACASAANYSSTQFDSAGVAYLDDIASMPCHTGSINSTDSERWKAINA
What are the official names of this protein?
Transmembrane protein adipocyte-associated 1, Integral membrane protein GPR175, TPRA40, Transmembrane domain protein of 40 kDa regulated in adipocytes.
What is the protein family that this protein belongs to?
Belongs to the UPF0359 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ROFG6_ARATH
Sequence: MEDNSCIGFEGSKRFGETSKRIIGLIDSVTESTTDSSLSSSSSGVGSSSGRSSVAERSVSSPPTKSQILGWPLGQGSWRKSSGKMKKKTPTKIDDFGFKRVGTETSEIELLKERMAKLLLGEDMSGSGEGVCPALAISNAITNLYAAILGQQWRLEPIPSEKKLMWRREIEVLLSVSDHIVELVPSFQNFPNGNKIEVMNCRPRSDLFTCLPALRKLDNMLIEILDSFGETEFWYVDQGIVAAESARSNSFREDGDKWWLPLPRVPSDGLTEQTRKKLDHTREFTNQILKACMSINSIALAEMEVPQSYLEALPKNGRSCLGDFLYRNITSDNFSADHLLESIDLSSELAVVEMANRVEASMYVWRRRAHSRHLISLYRSTSTRWGMIVKEMMMHQTDGDKREIFAERAESLLIRLKQRFPGLRQTALDTSKIQYNKDVGKSILESYSRVLESLAYSIGVRIEEVLFMDDISKDDGDGDDDSCSDKLRLLSKEAASGGSGSLREKLSAPSLFSVSFSGTSTPYRTLSFSASTPSYSPMPLISPINGGRGGERAPFLSGRNIRERCGFGPKKALANYLRG
What is the function of this protein?
Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP.
What are the official names of this protein?
Rop guanine nucleotide exchange factor 6, AtRopGEF6, Rho of plants guanine nucleotide exchange factor 6.
Protein: PRMA_LIMF3
Sequence: MNWTAIVVETSTEAVDAVSYILTDTGATGVKIDDAADYQKLKPGKYGPYGEIVDPSTLPHREEGAAVTGYYPPTTFVPEKIADIRQRVAKLADFGLNPAPARVAAEEIDNQDWATAWQKYYHPVRVTRELTIVPQWEEYTPATADEKLLVLDPGMAFGTGTHPTTQLMLQALTIALRGGESMIDVGTGSGVLSIAAKQLGAGEVWAYDIDDVAVKSAKKNLALNPIAKDVHTGVNSLLDGIHTQVDLVVANILAEIILPLVPQAFENLKPGGKFLTSGIINTKFETVKKAIEAQGFVVDETMRIKDWYGIIAHKPAPEEA
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDB_STRPS
Sequence: MKLLYTDIRTSLTEILTREAEELVAAGKRVFYIAPNSLSFEKERAVLECLSQQASFSITVTRFAQMARYLVLNDLPAKTILDDIGLGLAFYKCLAELNPKDLRVYGAIKQDPQLIQQLIELYHEMTKSQMNFLDLENLTDEDKRADLLLIFEKVTAYLNQGQLAQGSQLSHLIEAIENDKVSSDFNQIALVIDGFTRFSAEEERVVDLLHGKGVEIVIGAYASKKAYTSPFSEGNLYQASVKFLHHLASKYQTPAQDCSQTHEKMDSFDKASRLLESSYDFSELALDVDEKDRENLQIWSCLTQKEELELVARSIRQKLHENSDLSYKHFRILLGDVASYQLSLKTIFDQYQIPFYLGRSEAMAHHPLTQFVESILALKRYRFRQEDLINLLRTDLYTDLSQSDIDAFEQYIRYLGINGLPAFQQTFTKSHHGKFNLERLNVLRLRILAPLETLFASRKQKAENLLQKWSVFLKEGAVTKQLQDLTTTLEAVEQERQAEVWKAFCHVLEQFATVFAGSQVSLEDFLALLHSGMSLSQYRTIPATVDTVLVQSYDLIAPLTADFVYAIGLTQDNLPKISQNTSLLTDEERQNLNQATEEGVQLLIASSENLKKNRYTMLSLVNSARKQLFLSAPSLFNESESKESAYLQELIHFGFRRREKRMNHKGLSKEDMGSYHSLLSSLVAYHQQGEMSDTEQDLTFVKVLSRVIGKKLDQQGLENPAIPTSPSSKTLAKDTLQALYPAKQEFYLSTSGLTEFYRNEYSYFLRYVLGLQEELRLHPDARSHGNFLHRIFERALQLPNEDSFDQRLEQAIQETSQEREFEAIYQESLEAQFTKEVLLDVARTTGHILRHNPAIETIKEEANFGGKDQAFIQLDNGRSVFVRGKVDRIDRLKANGAIGVVDYKSSLTQFQFPHFFNGLNSQLPTYLAALKREGEQNFFGAMYLEMAEPVQSLMAVKSLAGAVVEASKSMKYQGLFLEKESSYLGEFYNKNKANQLTDEEFQLLLDYNAYLYKKAAEKILAGRFAINPYTENGRSIAPYVQQHQAITGFEANYHLGQARFLEKLDLADGKRLVGEKLKQAWLEKIREELNR
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: MENA_MYCLE
Sequence: MASFAQWISGARPRTLPNAVAPVVAGTGTAAWLHSAVWWKALLALVVAVALVIGVNYANDYSDGIRGTDDHRAGPMRLVGSRLAFPRSVLTAAVVGLTVSTVAGLALALLSAPWLIMVGATCIAGAWLYTGSSKPYGYKGFGEVAVFVFFGLVAVLGTEYTQALRVDWVGLVLAVSTGALSSSVLVANNLRDIHTDTQSHKFTLAVRLGDAHTRQLYQALLVATGVLTVVLMVATSWCAVGLVATPLALRAMRPVRSGRMGPDLTPVLRDTGLAMVVWAIAVAGALTLAGSVTY
What is the function of this protein?
Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
What are the official names of this protein?
1,4-dihydroxy-2-naphthoate octaprenyltransferase, DHNA-octaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MenA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYNB_ASPNC
Sequence: MRLSARGFVWSALLACTASALSEAAATASNSSQTLRTCVSQALVAGDVNTRIIDPSNDTYTDARLGEKIQFNEFPALIAYAKKAEEVASLVRCAQRSGFKAVPRSGGHHFEAWSALNGTLVIDLSHINHVNVSADTTTANVGAGIRQGALYLALDEHNVTFPGGICPTVALGGLVSSGGFSLQMRALGLAAEYVQSARVVLADGSLVTASSSSHEDLFWAIRGGGGGTYGIIVDFDLQLMQFPTSAMVAISWNASSDRYPVAQRFFDWAPVQIPAFTSQVNVYKSSINFLGQYLGGTENELRKLINESGLLNIGTPTVYISGNCDTDNSRLFGYTSYECVPANETNRQIMNVLPEPFSQYSDYPQYQYENEPEDPSIPIAEPWARFNRISKSFFMQKDNILPAADLKTVIDMMGQLDTDSEIWGEWHAWNISSATKADYAFPWREQAYAHLEFQVHGSLTNSTKQATYEKWFADLETYLRPKIGVASYSGEMDAHISTNPFESYYGDSVCRLVEVKKAYDPDNFFTNPDAITPTVPEGISC
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of pyranonigrins, a family of antioxidative compounds (PubMed:24106156, PubMed:26414728).  The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase that condenses 6 malonyl-CoA units to an acetyl starter unit, to form a 1,3,5-trioxotetradecane-6,8-dienyl-ACP (PubMed:24106156).  The enoyl reducrase (ER) domain of pynA is likely to be functional during the first two rounds of polyketide chain extension, to generate the saturated C-C bonds of the alkyl side chain (Probable).  PynA subsequently forms the amide bond between the acyl chain and L-serine (PubMed:24106156, PubMed:26414728).  Although pynA has a terminal reductase domain, it appears to require the thioesterase pynI for the release of the straight-chain intermediate from pynA via the formation of a tetramic acid pyranonigrin J (PubMed:26414728).  The methyltransferase pynC then coverts pyranonigrin J to pyranonigrin I via N-methylation (PubMed:26414728).  The FAD-dependent monooxygenase pynG catalyzes an epoxidation-mediated cyclization to form the dihydro-gamma-pyrone moiety, followed by pynD-catalyzed oxidation of the alcohol to the ketone and enolization to yield the characteristic tetramic acid-fused gamma-pyrone core of pyranonigrin H (PubMed:26414728).  Pyranonigrin H is substrate of pynH for dehydration-mediated exo-methylene formation from the serine side chain to produce pyranonigrin E, before the oxidase pynE reduces the exo-methylene of pyranonigrin E into a pendant methyl to form pyranonigrin G (PubMed:26414728).  The FAD-linked oxidoreductase pynB performs the reverse reaction and converts pyranonigrin G back to pyranonigrin E (PubMed:26414728).
What are the official names of this protein?
FAD-linked oxidoreductase pynB, Pyranonigrin biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: MRGA5_MOUSE
Sequence: MDKPLWKYGHLDSDPKLMIIIFRLVGMTGNAIVFWLLGFSLHRNAFSVYILNLALADFVFLLCHIIDSMLLLLTVFYPNNIFSGYFYTIMTVPYIAGLSMLSAISTELCLSVLCPIWYRCHHPEHTSTVMCAAIWVLPLLVCILNRYFCSFLDINYNNDKQCLASNFFTRAYLMFLFVVLCLSSMALLARLFCGTGQMKLTRLYVTIMLTVLGFLLCGLPFVIYYFLLFNIKDGFCLFDFRFYMSTHVLTAINNCANPIIYFFEGSFRHQLKHQTLKMVLQSVLQDTPEIAENMVEMSRNIPKP
What is the function of this protein?
Orphan receptor.  May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo.  May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity).
What are the official names of this protein?
Mas-related G-protein coupled receptor member A5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DTD_SALAR
Sequence: MIALIQRVTRASVTVEDEVTGEIGPGLLVLLGVEKEDDEQKANRLCERVLGYRIFSDADGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSGGAAPDRAQALYEYFVGRCRQQAINTQTGRFAADMQVELVNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_CLONN
Sequence: MKTFVEIVDVYARQILDSRGNPTVEVEVELEDGTVGRAAVPSGASTGIFEAVELRDNDKSRYMGKSVEKAVENVNEIIAEELVGLNVFDQVALDKIMIELDGTDNKGKLGANAMLGVSLACARAAAEYLGISLYQYIGGVNAKVLPVPMMNIMNGGSHADNNVDLQEFMIMPAGAKSFSHALRMCAEIYHTLKNILKDKGLSTGVGDEGGFAPNLESNEEAIQVIIEAVEKAGYKPGEEVFIALDPASSEFFNTETNKYELKGEGRELTPAEMVEYYAKLVEKYPIISIEDGMAEEDWDGWKLMTEKLGGKIQLVGDDLFVTNTKRLSMGIERKVANSILIKLNQIGTLTETLNTIEMAERAGYTAVVSHRSGETEDTTIADLVVAVNAGQIKTGAPARTERVAKYNQLLRIEEELNAMGEYRGLKAFYNIRK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: CTXN1_MOUSE
Sequence: MSSAWTLSPEPLPPSTGPPVGAGLDVEQRTVFAFVLCLLVVLVLLMVRCVRILLDPYSRMPASSWTDHKEALERGQFDYALV
What is the function of this protein?
May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.
What are the official names of this protein?
Cortexin-1.
What is the protein family that this protein belongs to?
Belongs to the cortexin family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CLD3_CANLF
Sequence: MSMGLEIAGTSLAVLGWLSTIVCCALPMWRVTAFIGSSIITAQITWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALIVVSILLAAFGLLVALVGAQCTNCVQDDTAKAKITIVAGVLFLLAALLTLVPVSWSANTIIRDFYNPLVPDAQKREMGAGLYVGWAAAALQLLGGALLCCSCPPRDKKYAPTKIVYSAPRSAGPGTSTAYDRKDYV
What is the function of this protein?
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
What are the official names of this protein?
Claudin-3.
What is the protein family that this protein belongs to?
Belongs to the claudin family.
What are the subcellular locations of this protein?
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Protein: LPXC_ALIF1
Sequence: MIRQRTLKSIVQMTGVGLHSGRKVTLTLRPAAANTGVIYRRTDLNPPVDFPADPESVRDTMLCTALVNDEGVRISTVEHLNAALAGMGIDNVVIEVDAPEIPIMDGSASPFVYLLQSAGIEELNTAKKFIRIKKPVRIEDGDKWAEIRPYNGFRLDFTIDFNHPAIESDDQKLVFDFSSQSFIKDISRARTFGFMRDIEYLQSQNLCLGGSFDCAIVLDDYRILNEDGLRFDNEFVTHKVLDAVGDLYMSGHSILGELRAYKSGHALNNQLLRAVLADQEAWEWTTIEDEQESPVAFMQPGMVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: DDL_BARQU
Sequence: MKGEHVAVLMGGGSSERSVSLSSGTACADILEARGYRVSRVDVDSHIASVLERLQPDVAFNALHGPFGEDGCIQGVLEYLKIPYTHSGVMASALAMDKGRAKIVVASVGVSVAPSCIMSRFAVGREHPMEPPYVIKPLCEGSSFGVVIVKENESAPPRNVVGAEWVYADEVIVEKYIPGREFTCAVLGNEALDVCEIFPDKHFQFYNYDSKYKSGGSLHICPAQLSPNIYQNVQRMSLAAHQAIGCRGVSRSDFRFNEETGELVWLEINTQPGMTPTSLFPDIAKASGRTYGDIVQWMVEDASCMR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_ROSS1
Sequence: MARGNDIERVVADNRKARHDYFIEETYEAGIALTGSEIKSIRAGQVNLRGGYVRIVDGEAWLYDVHIAPYEQSGAYFNHEPTRPRKLLLHRREISRIAGQVERQGYTLVPLRLYLRGRRAKVEIGLARGKKLYDKRDDIARREARRDIERALKERTRR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: DCAF8_MOUSE
Sequence: MSNKRPNTTDGRTDLANGSLSSSPEEMSGAEEGRETSSGIEVEASDLSLSLTGDDGGPNRTSTESRGTDTESSGEEKDSDSMEDTGHYSINDESRGHGHSDEEDEEQPRHRGQRKRASRDQDSSDDERALEDWVSSETTALPRPRWQALPALRERELGSSARFVYEACGARVFVQRFRLQHGLEGHTGCVNTLHFNQRGTWLASGSDDLKVVVWDWVRRQPVLDFESGHKSNVFQAKFLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLSAGEDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQYVRIYDQRKIDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQYIKRYKGHRNNATVKGVNFYGPKSEFVVSGSDCGHIFLWEKSSCQIIQFMEGDKGGVVNCLEPHPHLPVLATSGLDHDVKIWAPTAEASTELTGLKEVIKKNKRERDEDSLHHTDLFDSHMLWFLMHHLRQRRHHRRWREPGVGATDADSDESPSSSDTSDEEEGPDRVQCMPS
What is the function of this protein?
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
What are the official names of this protein?
DDB1- and CUL4-associated factor 8, WD repeat-containing protein 42A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat DCAF8 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent.
Protein: CAPSD_BYDVP
Sequence: MNSVGRRGPRRANQNGTRRRRRRTVRPVVVVQPNRAGPRRRNGRRKGRGGANFVFRPTGGTEVFVFSVDNLKANSSGAIKFGPSLSQCPALSDGILKSYHRYKITSIRVEFKSHASANTAGAIFIELDTACKQSALGSYINSFTISKTASKTFRSEAINGKEFQESTIDQFWMLYKANGTTTDTAGQFIITMSVSLMTAK
What is the function of this protein?
Major capsid protein.
What are the official names of this protein?
Major capsid protein, Coat protein, CP.
What is the protein family that this protein belongs to?
Belongs to the luteoviruses capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: TRUD_HELPJ
Sequence: MNLNFMPLLHAYNHVSIDFHFNSSARDFCVHEVPLYEFSNTGEHAVIQVRKSGLSTLEMLQIFSQILGVKIAELGYAGLKDKNALTTQFISLPKKYAPLLEKNTSNFQERNLKILSLNYHHNKIKLGHLKGNRFFMRFKKMTPLNAQKTEQVLEQIAQFGMPNYFGSQRFGKFNDNHKEGLKILQNETKFAHQKLNAFLISSYQSYLFNSLLSKRLEISKIISAFSVKESLEFFKQKNLSVHSNALKALKNQAHPFKILEGDVMRHYPYGKFFDALELEKESERFLNKEAVPTGLLDGKKALYAKNLSLEIEKGFQHNLLSGHAKTLGSRRFFWVFVENITSQYIKEKAQFELEFYLPKGSYASALLKEIKHEKGENNDEF
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: CPNE_DICDI
Sequence: MSDSSIVNLSKEGDSNFSSATINLSKVDDTVNVSNATINLSKVTIDPSNQMSNPSNQGINLSKCTKVELRFKCMNLKDMDTFSKSDPQIFVYEKKGNNNNNNNSKPILIGSTEMISNNLNPVFKKTVTIDYHFERIQNLKFEVLDIDGGGKNDTIGDFSITLGNIISKPGKKVIGEIKCNGKQTGTIEIIAEEIQETGQNIILKLQGSKLDKKDLFSSDPFFKIFKSSANGNLLVYQSPVIKSNINPIYNPIIFKLEEFNGGDMFRELTFEFWDYDTIGDNDFIGSFKTTTDEILKGQVREFTLINPKKLSKSSYKNSGKIVFTDARLIAQPTFIDYLSGGCEINLMIAIDCTASNGMPSDRTSLHYNTPTHESEYARSILAVGNVLAPYDSDGKIELLGFGAERFGGVTSHCFQFGPKAEARGIEEVLSTYNKVIPTIKLSYPTNFQEIIKHAHKKSIKGVDSKNQKYTILLILTDGEITDMEETIEEIVKASSKAPLSIVIVGVGIASFELMKKLDGDENQLSDKNGVIATRDIVQFVPFKKYENDPEQLAAETLCEIPEQLIGYMKSQNYFPNMKN
What are the official names of this protein?
Copine-E.
What is the protein family that this protein belongs to?
Belongs to the copine family.
Protein: ARLY_BURO0
Sequence: MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISADDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYVEMFTRDAERMRDCRTRVNRLPLGAAALAGTSYSIDRHAVAKTLGFDGICANSLDAVSDRDFAIEFTAASALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMAAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKICDDRGIDLADLTLDEMKQELPNVAHLIGDDVFGYLTLEGSVASRNHPGGTAPDQVRAAVKAARAALAK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
Protein: MSCL_BACFR
Sequence: MGKSTFLQDFKAFAMKGNVVDMAVGVIIGGAFGKIVSSVVADIIMPPLGLLIGGVNFTDLKWVMKAAEYGADGKETAAAVTLNYGNFLQATFDFLIIAFSIFLFIKLITKLTQKKAEAPAAPPAPPAPTKEEILLTEIRDLLKEKQ
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.