PharMolix/UniProtQA huggingface dataset:
Protein: ATG10_ARATH
Sequence: MDSAREVSDGRLTVEGFSVASRAFADKWKIHNQSFPPWSWVPLINRTLLVSKKEEGYLSLEKIIILSSLEEEIPEDESLNVATDCLEKEETVDHTILVPTMENEAHYYDFHIVYSASYKVPVLYFRGYCSGGEPLALDVIKKDVPSCSVSLLLESKWTFITQEEHPYLNRPWFKLHPCGTEDWIKLLSQSSSSSGCQMPIVLYLVSWFSVVGQVVGLRIPLEMLN
What is the function of this protein?
E2-like enzyme involved in autophagy.  Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5.  The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD).  Likely serves as an ATG5-recognition molecule.  Confers some resistance to nitrogen and carbon starvation.  Is also involved in the formation of anthocyanic vacuolar inclusions (AVI).  Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the containment of host tissue-destructive microbial infections during necrotrophic pathogen infection, but negatively controls SA-dependent defenses and basal immunity to bacterial infection during biotrophic infection.
What are the official names of this protein?
Ubiquitin-like-conjugating enzyme ATG10, Autophagy-related protein 10, AtATG10.
What is the protein family that this protein belongs to?
Belongs to the ATG10 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: C5AP_STRPY
Sequence: MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPVTEQAVETPQPTAVSEEVPSSKETKTPQTPDDAEETIADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKTKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETAMVKTDDQQDKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDIDFKDKVANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKVLYEASWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDPTKEELMSIPYIGFRGDFGNLSAVEKPIYDSKDGSSYYHEANSDAKDQLDGDGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAGTFAKQDDDSHYYIHRHANGEPYAAISPNGDGNRDYVQFQGTFLRNAKNLVAEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGKVVANGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRRLTLASKPKTSQPVYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETMEGATVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHSNKPEQDGSGQTPDKKPEAKPEQDGSDQAPDKKPEAKPEQDGSGQTPDKKPETKPEKDSSGQTPGKTPQKGQPSRTLEKRSSKRALATKASTRDQLPTTNDKDTNRLHLLKLVMTTFFFGLVAHIFKTKRQKETKK
What is the function of this protein?
This virulence factor of S. pyogenes specifically cleaves the human serum chemotaxin C5a at '68-Lys-|-Asp-69' bond near its C-terminus, destroying its ability to serve as a chemoattractant.
What are the official names of this protein?
C5a peptidase, SCP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor.
Protein: MNMA_SHIDS
Sequence: MSETAKKVIVGMSGGVDSSVSAWLLQQQGYQVEGLFMKNWEEDDGEEYCTAAADLADAQAVCDKLGIELHTVNFAAEYWDNVFELFLAEYKAGRTPNPDILCNKEIKFKAFLEFAAEDLGADYIATGHYVRRADVDGKSRLLRGLDSNKDQSYFLYTLSHEQIAKSLFPVGELEKPQVRKIAEDLGLVTAKKKDSTGICFIGERKFREFLGRYLPAQPGKIITVDGDEIGEHQGLMYHTLGQRKGLGIGGTKEGTEEPWYVVDKDVENNILIVAQGHEHPRLMSIGLIAQQLHWVDREPFTGTMRCTVKTRYRQTDIPCTVKALDDDRIEVIFDEPVAAVTPGQSAVFYNGEVCLGGGIIEQRLPLPV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis.  Sulfur is provided by IscS, via a sulfur-relay system.  Binds ATP and its substrate tRNAs.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOME2_MOUSE
Sequence: MGEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSELQLTKFAEKFQEVREAARLARDKSQEKTETSSNHSQESGCETPSSTQASSVNGTDDEKASHASPADTHLKSENDKLKIALTQSAANVKKWEMELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRSKIEELEEQCSEINREKEKNTQLKRRIEELESEVRDKEMELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKGELKSFLEVLDGKIDDLHDFRRGLSKLGTDN
What is the function of this protein?
Postsynaptic density scaffolding protein.  Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3.  By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.  May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity).  Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing (PubMed:25816005).  Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway.  Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
What are the official names of this protein?
Homer protein homolog 2, Homer-2, Cupidin, VASP/Ena-related gene up-regulated during seizure and LTP 2, Vesl-2.
What is the protein family that this protein belongs to?
Belongs to the Homer family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Postsynaptic density. Synapse. Cell projection, stereocilium. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
Protein: RPOC_CAMFF
Sequence: MSELKPIEIKEDAKPRDFEAFQLRLASPDRIKAWSHGEVKKPETINYRTLKPERDGLFCAKIFGPIRDYECLCGKYKKMRYKGIKCEKCGVEVTTSKVRRSRMGHIELVTPVAHIWYVNSLPSRIGTLLGIKMKDLERVLYYEAYIVENPGDAFYDNENSKKVDLYDVLNEEQYVLLEQKFSESGFKARMGGEVIRDLLASLDLVSILDQLKIEIESTNSEAKKKTIVKRLKVVESFLNSGNRPEWMMITNLPVLPPDLRPLVSLDGGKFAVSDVNDLYRRVINRNTRLKRLMELDAPEIIIRNEKRMLQEAVDALFDNGRRANAVKGANKRPLKSLSEIIKGKQGRFRQNLLGKRVDFSGRSVIVVGPKLRMDQCGLPKKMALELFKPHLLARLEEKGYATTVKQAKKMIEDKTNEVWECLEEVVADHPVMLNRAPTLHKMSIQAFHPVLIEGKAIQLHPLVCSAFNADFDGDQMAVHVPLSQEAIAECKILMLSSMNILLPASGKAVTVPSQDMVLGIYYLSLEKNEAVGANKIFASVDEVMIAVEAHYLDLHAKIKTMVEGRTVFTTAGRLIIKSILPNLKENSVPESMWNKVMKKKDIANLVDYVYKNGGLEVTAGFLDKLKNLGFRYATKAGISISIADIIIPESKYSYVDEAKKRVREIQNQYGSGLLTDSERYNKIVDIWTDTNNKVAAEMMKLIKTDKSGFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITSNFREGLNVLEYFISTHGARKGLADTALKTANAGYLTRKLIDVAQNVKVTMDDCGTHEGVEITEITENGELIESLEERVLGRVLSDDVIDPITNEILFTEGTLIDEVKARTITDAGIKSVSIRTPITCKASKGVCSKCYGINLGEGKLVKPGEAVGIISAQSIGEPGTQLTLRTFHIGGTASTEQQDRQVVAQKEGFIRYYNLKTYENNNKFIVTNRRNAAILLVEPKIKAPFDGEINIEVAHEDINVIIKGKSDEVKYVLRKHDLAKPNELAGVSGKVEGKFYIPYIKGDKVKENESIVEVIKEGWNVPNRIPFASEVKVADGDPVTQDILSGANGVLKFYILKGDYLERIKNVKKGDMVSEKGLFVVIADDDDREAVRHYIPRNSVIKFNDSDIVSAKDTIAKPQDGSKLVIAEWDPYSTPVIAEEAGTVAYEDIEPGYSVAEQYDEATGESRLVINEYLPSGVKPTIVISTKSGKLIRYQLEPKTAIFVKDGAEVSRADTIAKTPKAVAKSKDITGGLPRVSELFEARRPKNTAIIAEIDGTIKFDKPLRSKERIIIMAEDGSSAEYLIDKSRQIQVRDGEFVHAGEKLTDGLVSSHDVLRILGEKALHYYLISEIQQVYRSQGVAISDKHIEIIVSQMLRQVKIVDSGHTNFIVGDMVSRRKFREENDRIMKIGGEPAIAEPVLLGVTRAAIGSDSVISAASFQETTKVLTEASIAAKFDYLEDLKENVILGRMIPVGTGLYQDKKVKIKINED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: YCEI_ECOL6
Sequence: MKKSLLGLTFASLMFSAGSAVAADYKIDKEGQHAFVNFRIQHLGYSWLYGTFKDFDGTFTFDEKNPAADKVNVTINTTSVDTNHTERDKHLRSADFLNTAKYPQATFTSTSVKKDGDELDITGDLTLNGVTKPVTLEAKLIGQGDDPWGGKRAGFEAEGKIKLKDFNIKTDLGPASQEVDLIISVEGVQQK
What are the official names of this protein?
Protein YceI.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: ISS1_ARATH
Sequence: MGSFGMLSRRTLGTDMPVMAQIRSLMAELTNPMSLAQGVVHWQPPQKALEKVKELVWDPIISSYGPDEGLPELRQALLKKLREENKLTNSQVMVTAGANQAFVNLVITLCDAGDSVVMFEPYYFNSYMAFQMTGVTNIIVGPGQSDTLYPDADWLERTLSESKPTPKVVTVVNPGNPSGTYVPEPLLKRIAQICKDAGCWLIVDNTYEYFMYDGLKHCCVEGDHIVNVFSFSKTYGMMGWRLGYIAYSERLDGFATELVKIQDNIPICAAIISQRLAVYALEEGSGWITERVKSLVKNRDIVKEALEPLGKENVKGGEGAIYLWAKLPEGHRDDFKVVRWLAHRHGVVVIPGCASGSPGYLRVSFGGLQEVEMRAAAARLRKGIEELLHHGMVE
What is the function of this protein?
Coordinates and prevents auxin (IAA) and ethylene biosynthesis, thus regulating auxin homeostasis in young seedlings (PubMed:23377040, PubMed:26163189).  Shows aminotransferase activity with methionine; can use the ethylene biosynthetic intermediate L-methionine (L-Met) as an amino donor and the auxin biosynthetic intermediate, indole-3-pyruvic acid (3-IPA) as an amino acceptor to produce L-tryptophan (L-Trp) and 2-oxo-4-methylthiobutyric acid (KMBA) (PubMed:23377040).  Can also use tryptophan (Trp), phenylalanine (Phe), and tyrosine (Tyr) as substrates.  Regulates tryptophan (Trp) homeostasis and catabolism in mature plants.  Also possibly involved in the metabolism of other aromatic amino acids and phenylpropanoid homeostasis (PubMed:26163189).
What are the official names of this protein?
Aromatic aminotransferase ISS1, Methionine aminotransferase ISS1, Phenylalanine aminotransferase ISS1, Protein INDOLE SEVERE SENSITIVE 1, Protein REVERSAL OF SAV3 PHENOTYPE 1, Tryptophan aminotransferase ISS1, Tyrosine aminotransferase ISS1.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CGLR1_DROER
Sequence: MVRNLEDFCNEANAKHIRIEDRERYTGHFNALKDMVYSYWKKSKGLDKLVKGTTLCGGYGDNLKVSKPDEYDLLIHLVFPENDKIIVKADASNPGNVLLDMTKVMEIIAKQEHNKPVFDLLQKIVNNKKQLLEDKLQSFLHGIMTQTLNKMGNRIEVQGEISHLSYKKCGPAHNILVKGPCEYSVDFVPAIKLSAAQLVLAPEQRKHFGGTLYWDAVPKPMKPAKPDNPSFRTSFYEAERSLLHGKQNLKSAIRMIKHIRNEKNKANLKSYHIKTVFLWQVMEKDASYWEKPKKEILIEMLGKLADLLALTPRKGRLPYFWDPKLDMFADLTDDQRTDMFNCFRKCEYVFRKADGNLNDDNENSVHSSFKGSGRNGQKMEKTSTESEQKKPTETKPNAKVESTPVKPNPKPSVQEKQAKPNLADQKKCTKNANGTKSKTTTPKPS
What is the function of this protein?
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:34261127).  Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG (By similarity).  Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:34261127).  Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish) (By similarity).
What are the official names of this protein?
Cyclic GMP-AMP synthase-like receptor 1, cGLR1.
What is the protein family that this protein belongs to?
Belongs to the mab-21 family.
Protein: OBG_BUCBP
Sequence: MKFLDKAIIHVIAGNGGHGRTSFRREKYIPKGGPDGGDGGNGGNVWLQTVTNLNTLIDFKFTKIFKAQDGQQGFNKKKTGKKGSDIVIQIPIGTKIIDHNTNEIIEDMIQDKQLVLVAKGGWHGLGNTRFKSSTNRIPIKHTKGTQGEFRILRLELILIAHVGTLGLPNSGKSTLVRNISNAKTKIANYPFTTLKPVLGTVKINHKEFFVIADIPGLIQGASHGIGLGYQFLKHLERCHLLLHIIDISQINFKNTITNIHVILDELKTYNKILHNKPIWFVFNKIDLIDDIDINTKLKSILEKLGSIQQYFLISAIKKTGLKKIVKKIYDFLKNKNLL
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGGGP_METS3
Sequence: MNPYVEIIRPGNVIMAIIAVILVAILAKSVDIPIILAMLAVFFAMSAGNVINDYFDYKIDLINKPQRPIPSGRISLDNAKNYAYLLFILAAIVGFLISCLVDTWIPCTIVIFSDIILYLYAYKLKSTPLIGNLTVGFMTGLCFIFAGYTFNEGLIIYESYLLAFFALIMTTAREITKDIEDMEGDMAEGAKTFPILYGPKISAIIAISLIIIDCALCPLLYIYHIFNINYLIVVSIAVLIFLYGAVLLRNQDSKTANKVSKYLKTGMLIAFIAFAIGTFTITF
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP).  This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Digeranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UNG_HELHP
Sequence: MTINLDKIKIPDDWKQLLASEFLSPYFADIKTHYLNALQNKEMIYPKPHQIFAAFNLTPLSSLKVVILGQDPYHGSGIIEGVETPQAMGLSFSVPRGMPIPPSLKNIYAELSQSLHITPPTHGDLSGWARQGVLLLNAILSVRANAPASHKHFGWEYFSDGVIRALSAHKEHLVFMLWGNYAKKKAPLIDASKHKIITAPHPSPLARGFVGSNVFLQANIYLQEHAKEPIAWEKL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCNA2_PYRAE
Sequence: MSVRALFPKGKEPRYAFEVLIRMLPEAVLNFSSDGISLKALDPTKTALLDLTFYATALEDYSIDEETKVGIIFTTIKDVIKRIGATEKLELEVDKERNRFSFYIYPKKGREVGLVRRFSFPIVQVLEEEIPELAVSFDASFEIDSAVLDDILAMVDEVSDWIQITVSPDKVLFRGVGEGGKAAETELSYDSESVFNISAGEAASAKYSVEMLRDISGKMKSLSKRVKVELSANKPIRLTYEFTSGVFTATIAPRVD
What is the function of this protein?
Sliding clamp subunit that acts as a moving platform for DNA processing.  Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
What are the official names of this protein?
DNA polymerase sliding clamp 2, Proliferating cell nuclear antigen homolog 2, PCNA 2.
What is the protein family that this protein belongs to?
Belongs to the PCNA family.
Protein: THIG_BACC0
Sequence: MLNIGPFSFHSRLLLGTGKFPDFDVQQKAIDVSEAEVLTFAVRRMDIFDAKQPNLLEKLDVKKYKLLPNTAGAKNAEEAVRIAKLAKASGLCDMIKVEVIGDDRTLLPDPVETLRASEMLLEEGFIVLPYTSDDVVLARKLQELGVHAIMPGASPIGSGLGIVNPLNLSFIIEQATVPVIVDAGIGSPADAAFAMELGADGVLLNTAVSGAKDPIKMAQAMKLSIEAGRLGFEAGRIARKRCATASSPLEGMSVVE
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDK2_XENLA
Sequence: MENFQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINSDGAIKLADFGLARAFGVPVRTFTHEVVTLWYRAPEILLGCKFYSTAVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPKWIRQDFSKVVPPLDEDGRDLLAQMLQYDSNKRISAKVALTHPFFRDVSRPTPHLI
What is the function of this protein?
Involved in the control of the cell cycle.  Interacts with cyclins A, B, D, or E.  Activity of CDK2 is maximal during S phase and G2.
What are the official names of this protein?
Cyclin-dependent kinase 2, CDC2 homolog Eg1 protein kinase, Cell division protein kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Protein: CCW22_YEAST
Sequence: MQFSTVASIAAIAAVASAASNITTATVTEESTTLVTITSCEDHVCSETVSPALVSTATVTVNDVITQYTTWCPLPTTEAPKNTTSPAPTEKPTEKPTEKPTQQGSSTQTVTSYTGAAVKALPAAGALLAGAAALLL
What is the function of this protein?
Cell wall protein necessary for cell wall integrity.
What are the official names of this protein?
Putative covalently bound cell wall protein 22.
What is the protein family that this protein belongs to?
Belongs to the PGA59 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor.
Protein: IMQF_ASPFN
Sequence: MMTEAQGPVVSIGSATVTYDHPPIISPVSYPKARPTQILDIRKRTSRIDLYHEILAGLRAKDKELPSLLLWNDRGLDLFSEILNSDEYYPRRRETQLLQTHVNEFTRSISSGERLIELGAGNLQKTVSVLRCLEQSRKHVEYCALDVSHAALQASITELKAQLPFASYVTIRGLLGTYNDCASWLKQSGATVRTTFLWLGNSIANFEPEDATSILADFLQTKASPSHSPQMIIAVDGCQDVEQILEAYDMPNKLSQKFVFNGLSHANQILGSEVFRPQHWTFEGKWNPVKSMHESFYVAKKPMSLDIGNERFHVHAGEKIRAITSGKWPKDKVTSICQSAGIKVLKGWTDEEGSYGKRVTQVYSRGSSC
What is the function of this protein?
N-methyltransferase; part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination (PubMed:29182847).  ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors (PubMed:29182847).  N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline (PubMed:29182847).  Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation (PubMed:29182847).  The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH (PubMed:29182847).  Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins (PubMed:29182847).
What are the official names of this protein?
N-methyltransferase imqF, Imizoquin biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: AMPA_SINFN
Sequence: MPMKFEFTFSKSHRPAGGSAVLLQVAGAKEPAGVAVVDPEGVLPKAAKIGKFSGKALSSLDIVAPHGSPADRIILLGLGDAAALTSHDWLKAGGAAAAKLRSADKATIFLDAPGVDVTGKAAADFALGMEMNAYAFDSYKTRKSDDESKSAQKVVKVTIVTGMVIAAKKAFATVQSIGEGVFLARDLVNEPANVLGPVEFAARAKELEKLGVEVETLTEREMKKLGMGALLGVAQGSSRPPRLVVMQWKGGKAKDKPLAFIGKGVVFDTGGISIKPASGMEEMKGDMGGAAAVTGLMHVLAARKASVNAVGIIGLVENMPDGSAQRPGDIVTSMSGQTIEVINTDAEGRLVLCDALWYCNDRFKPKAMIDLATLTGAIMVALSNHYAGLFSNDDRLAEQLLKAGTTTHERLWRMPLGKEYDKMIDSKFADMKNTGGRHGGSVTAAQFLKRFVKDTPWAHLDIAGTAMGSPTDEINQSWGSGFGVRLLDELVRANYES
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_LATSS
Sequence: MKVVLQRVSQASVTIEEQVVGQINKGFLLLVGICDDDTEADLDYLVKKISQLRVFEDEAGKMNLALGQVNGAILSVSQFTLYASTKKGNRPSFTDAGQPDYAQKMYNLFNQKLAATGIAVETGEFGADMQVALVNDGPVTILFDTRDN
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4M_OSPRO
Sequence: MLKILVPTIMLIPLTWYSKKQWVWINPTAHSFLISIASLTLLYHSTDLGYSYSSSFYMDSLSGPLLVLSCWLLPLMMIASQNHLMKEPLNRKKTFLTTLIILQTSLIMAFSSSELIMFYIMFEATLIPTLIIITRWGNQNERLNAGLYFLFYTLTGSLPLLVALLYLHSKIGTLHILTLIMNPKPMELSMPNSILWYACTVAFMVKMPMYGLHLWLPKAHVEAPIAGSMVLAAILLKLGGYGIMRITILTQPITAHVYYPFIVLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMGLVIVAALMQSTLSFMGATALMIAHGLTSSMLFCLANTNYERIHSRTMILARGLQLILPLMCTWWLLASLANLALPPTINLLGELAVIISSFSWSHFSIILLGANTVITALYSLHMLITSQRGKFTHHLYPMKPSFTREHILMMLHMIPLLIISMNPKFILGITY
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4, NADH dehydrogenase subunit 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: EFP_LEPIN
Sequence: MTLGITEVKKGMVLKVEGDLYSVVKTEFVNPGKGSAFIRTKLKNLTRNSSIERTFKAAEKLESVELEKRNMTICYTEGDDIIFMDSNDFEQMPVSKEYVEDILPFLKEETPMEVTFYEGKPIGVIPPNFSILEVTYAEEGLKGDTSGTAQKRITVETGGEINVPIFVKQGDVIKIDLRDLTYVERVSK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_SHESM
Sequence: MKFELDTTDGRARRGRLIFERGTVETPAFMPVGTYGTVKGMTPEEVRATGADILLGNTFHLWLRPGEEIMRKHGDLHDFMNWQRPILTDSGGFQVFSLGDIRKITEEGVHFRSPINGEKIFLDPEKSMQIQHALGSDVVMIFDECTPYPATEDEARKSMQMSLRWAKRSRDEFDRLENPNSLFGIIQGSVYEDLRDESLKGLVEIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFTSEGVIKIRNARHRDDTSPLDPKCDCYTCKNYSRAYLYHLDRCNEILGARLNTIHNLRYYQMLMEGLRGAIETGTLDAFVKDFYTSQGREVPELVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.