PharMolix/UniProtQA huggingface dataset:
Protein: RS14_RICB8
Sequence: MAKVSSIKKNEKRKKLSQSLHNKREKLKNKIYDKNISLEERFSLVMSLAQLSRNSSATRIRNRCELTGRPRGVIRKFGISRNKLRELSGRGLVPGIIKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: DSG4_RAT
Sequence: MDWLLFRNICLLILFMVVLGVNSEFIVEVKELDIENGTTTWQTVRRQKREWIKFAAACREGEDNSKRNPIARIRSDCEVSQRITYRISGAGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLERPLELRVKVMDVNDNPPVFTQNVYTANIEENSDANALVVKLSATDADEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDREQHSMYNLLVRGSDRDGATDGLSSECDCRIKILDVNDNFPILEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILKLVKMLDYEQEPNIYLSIGVRNQAEFHHSVASQFQMHSTPVRIQVINVREGPTFRPSSMTFSLRGGMRGDSLMNYVLGTYTAIDMDTGSPATNVRYVIGHDAGSWLKVDSRTGEIQFSREFDTKSKYITDGMYAAEILAIDDGSGRTATGTICIEVPDANDYCPVIYAESRSVCTHASSVRIYVNDHSFGAPFTFCVVDESPDTADIWDIRSINGTSAILMTEQTLSPGPYQIPILVKDSHNRACELPQTVLLDACLCDDYHVCLHSSTTGIYTGDTIWVTDDMGTVTDDGLRQSNVGLGPAGIGMIILGLLLLFLSPLLLLMCCCKRRQPEGLGTRFAPVPEGGEGVMQPWRIEGAHPEDRDVSNICVPMTASNTQDRIDSSEIYTNTYAGGGTVEGGVSGVELNTGVGTAAGIAAGGATGTLRKRSSTIGTLREYQDTGMNMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGTGSPVGSIGCCSWIVDDLDESYMETLDPKFRTLAEICLDTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGMTLSEAEFQAEMAAASEPMIHGDIIVTETYTATDPCVQPTTIVFDSQLPPNVVVTETVMAPVYDVQGNICVPAEIANTHNVYYAERVVASPGVPDMGNGNIGDTCIGPVMSGGILVGPEIQVTQMMSPDIHISQTTRSTSPMTSQHRVTRYSNIHYSRQ
What is the function of this protein?
Component of intercellular desmosome junctions.  Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.  Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).
What are the official names of this protein?
Desmoglein-4.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Protein: RS5_METTH
Sequence: MIMNFNMEEWEPRTQLGRLVKEGVITSIDEIFEEGHPIMELEIIDALLPDLEEEVIDVNLVQRMHKSGRKVNFRVIVAVGNKDGYVGLGQGKAREVGPAIRKAVDDAKFNIIKVRRGCGDWGCVCGREHTVPFKVSGKSGSVRVTLIPAPGGVGLAIGDVGKTIMRLAGIDDVWSHTRGQTQTTVNFARATFDALKQLSKVKASEKDLKNLGVCST
What is the function of this protein?
With S4 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: ARGJ_AGRFC
Sequence: MSVAVSPLAPKSYPDMPALRGVRMATAAAGIKYKNRTDVLLMVFDKPASVAGVFTKSKCPSAPVDFCRANLGSGAARAVVVNSGNANAFTGVKGKAATELTAKSAAAAVGCSEGEIFLASTGVIGEPLDASKFAGVLGDMNVRAEADFWQEAAKAIMTTDTYPKVSTRTAEIGGVIVTINGISKGAGMIAPDMATMLSFVVTDADIEPAALQSLLSAGVGPTFNSVTVDSDTSTSDTLMLFATGAAAEDGQVKVTSADDERLSSFRAALNDLLKDLALQVVRDGEGARKMVEVTVTGAENDAAAKKIALSIANSPLVKTAVAGEDANWGRVVMAVGKSGEMADRDRLAIWFGGVRVAVNGERDPDYSEAETTAVMRLEDITVKVDIGLGQGTATVWTCDLTKEYVAINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNTK_HUMAN
Sequence: MAAPGALLVMGVSGSGKSTVGALLASELGWKFYDADDYHPEENRRKMGKGIPLNDQDRIPWLCNLHDILLRDVASGQRVVLACSALKKTYRDILTQGKDGVALKCEESGKEAKQAEMQLLVVHLSGSFEVISGRLLKREGHFMPPELLQSQFETLEPPAAPENFIQISVDKNVSEIIATIMETLKMK
What are the official names of this protein?
Probable gluconokinase, Gluconate kinase.
What is the protein family that this protein belongs to?
Belongs to the gluconokinase GntK/GntV family.
Protein: RPOZ_CLOD6
Sequence: MLKPSINEVLEKIDNRYYLVGTVSKRARKLIDGEEPYVSNKTKEKPVCVATKEVASGKITYRLLTEEEIEIEEARHHAEQHQQISEEE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: CLSA_SALSV
Sequence: MTTFYTVVSWLVILGYWVLIAGVTLRILMKRRAVPSAMAWLLIIYILPLVGIIAYLSVGELHLGKRRAERARAMWPSTAKWLNDLKACKHIFAQENSSVASSLFKLCERRQGIAGVKGNQLQLLTDSDDVMQALIRDIQLARHNIEMVFYIWQPGGMADQVAESLMAAARRGIHCRLMLDSAGSVAFFRSPWAAMMRNAGIEVVEALKVNLMRVFLRRMDLRQHRKMVMIDNYIAYTGSMNMVDPRFFKQDAGVGQWVDLMARMEGPVATAMGIVYSCDWEIETGKRILPPPPDVNIMPFEQASGHTIHTIASGPGFPEDLIHQALLTATYAAREYLIMTTPYFVPSDDLLHAICTAAQRGVDVSIILPRKNDSLLVGWASRAFFSELLAAGVKIYQFEGGLLHTKSVLVDGELSLVGTVNLDMRSLWLNFEITLVIDDTGFGADLAAVQDDYISRSRLLDARLWVKRPLWQRITERLFYFFSPLL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NAGZ_XYLFA
Sequence: MLLIGVAGTTLSAQEVDWLQDDAVAGVVLFKRNFASRAQIVELSAALREATPRPLLLAVDQEGGRVQRFHEGYSALPPLQGVGALYARDPEAALELAFEHAWLMASEVRASGVDLSFAPVIDLGRGNRAIGNRAFSDDPHVVAAFARAYVQGMHAAGMPVTLKHFPGHGSVLEDTHVDLAVDVRPLETLECEDLVPFAAGIAAGADAVMMAHVVYPNVAPEPAGFSAHWIEVILRGRMGFRGVVFSDDIGMAAVRGVGSVAGCVHAHLDAGCDVVLVCHPELVNDALSAVAGRRSNTAALIGLIGRGALGWDGLLADVRYGSIQSRLLERFGTST
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_PHOV8
Sequence: MSERKVRVRFAPSPTGALHIGGVRTALYNYLFARQHGGDLIFRIEDTDSNRFVPGAEEYIIESFKWLGINFDEGVSFGGNYGPYRQSERRDIYKKYVQVLLDSGKAYIAFDTPAELDAKRQEISNFQYDASTRMSMRNSLTLPKEEVDALIADGKQYVVRFKIEPNEDVHVHDIIRGEVVINSSILDDKVLYKSADELPTYHLANIVDDHLMEVSHVIRGEEWLPSAPLHVLLYRAFGWADTMPEFAHLPLLLKPDGNGKLSKRDGDRLGFPVFPLEWHDPKTGEVSSGYRESGYLPEAVINFLALLGWNPGNDQELMSLDELVKLFDLHRCSKAGAKFDFEKGKWFNHEYILKKSNEEVAGLFMPILKEHGIEAPMDKVVTVVGLMKDRVSFIKDLWETCKFFFVAPTEYDEKTRKKRWKEDSPERMLELADVLEALDDFSLENQEAVVMKWIEDKGYHLGNIMNAFRLTLVGEGKGPHMFDISAVLGKEETLRRIRRAVEVLK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P6_BPPM2
Sequence: MANFLTKNFVWILAAGVGVWFYQKADNAAKTATKPIADFLAELQFLVNGSNYVKFPNAGFVLTRDALQDDFIAYDDRIKAWLGTHDRHKDFLAEILDHERRVKPVYRKLIGNIIDASTIRAASGVEL
What are the official names of this protein?
Protein P6, Protein VI.
What are the subcellular locations of this protein?
Virion membrane. Note=Part of the capsid inner membrane.
Protein: TENS2_HUMAN
Sequence: MKSSGPVERLLRALGRRDSSRAASRPRKAEPHSFREKVFRKKPPVCAVCKVTIDGTGVSCRVCKVATHRKCEAKVTSACQALPPVELRRNTAPVRRIEHLGSTKSLNHSKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSGSIRMNSSPLFLHYVLIPMLPAFEPGTGFQPFLKIYQSMQLVYTSGVYHIAGPGPQQLCISLEPALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDERFPFQASVEFVFSSSPEKIKGSTPRNDPSVSVDYNTTEPAVRWDSYENFNQHHEDSVDGSLTHTRGPLDGSPYAQVQRPPRQTPPAPSPEPPPPPMLSVSSDSGHSSTLTTEPAAESPGRPPPTAAERQELDRLLGGCGVASGGRGAGRETAILDDEEQPTVGGGPHLGVYPGHRPGLSRHCSCRQGYREPCGVPNGGYYRPEGTLERRRLAYGGYEGSPQGYAEASMEKRRLCRSLSEGLYPYPPEMGKPATGDFGYRAPGYREVVILEDPGLPALYPCPACEEKLALPTAALYGLRLEREAGEGWASEAGKPLLHPVRPGHPLPLLLPACGHHHAPMPDYSCLKPPKAGEEGHEGCSYTMCPEGRYGHPGYPALVTYSYGGAVPSYCPAYGRVPHSCGSPGEGRGYPSPGAHSPRAGSISPGSPPYPQSRKLSYEIPTEEGGDRYPLPGHLASAGPLASAESLEPVSWREGPSGHSTLPRSPRDAPCSASSELSGPSTPLHTSSPVQGKESTRRQDTRSPTSAPTQRLSPGEALPPVSQAGTGKAPELPSGSGPEPLAPSPVSPTFPPSSPSDWPQERSPGGHSDGASPRSPVPTTLPGLRHAPWQGPRGPPDSPDGSPLTPVPSQMPWLVASPEPPQSSPTPAFPLAASYDTNGLSQPPLPEKRHLPGPGQQPGPWGPEQASSPARGISHHVTFAPLLSDNVPQTPEPPTQESQSNVKFVQDTSKFWYKPHLSRDQAIALLKDKDPGAFLIRDSHSFQGAYGLALKVATPPPSAQPWKGDPVEQLVRHFLIETGPKGVKIKGCPSEPYFGSLSALVSQHSISPISLPCCLRIPSKDPLEETPEAPVPTNMSTAADLLRQGAACSVLYLTSVETESLTGPQAVARASSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFFRRHYPVNSITFSSTDPQDRRWTNPDGTTSKIFGFVAKKPGSPWENVCHLFAELDPDQPAGAIVTFITKVLLGQRK
What is the function of this protein?
Tyrosine-protein phosphatase which regulates cell motility, proliferation and muscle-response to insulin (PubMed:15817639, PubMed:23401856).  Phosphatase activity is mediated by binding to phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3) via the SH2 domain (PubMed:30092354).  In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy (PubMed:23401856, PubMed:30092354).  Negatively regulates PI3K-AKT pathway activation (PubMed:15817639, PubMed:23401856, PubMed:30092354).  Dephosphorylates nephrin NPHS1 in podocytes which regulates activity of the mTORC1 complex (PubMed:28955049).  Under normal glucose conditions, NPHS1 outcompetes IRS1 for binding to phosphatidylinositol 3-kinase (PI3K) which balances mTORC1 activity but high glucose conditions lead to up-regulation of TNS2, increased NPHS1 dephosphorylation and activation of mTORC1, contributing to podocyte hypertrophy and proteinuria (PubMed:28955049).  Required for correct podocyte morphology, podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier (By similarity).  Enhances RHOA activation in the presence of DLC1 (PubMed:26427649).  Plays a role in promoting DLC1-dependent remodeling of the extracellular matrix (PubMed:20069572).
What are the official names of this protein?
Tensin-2, C1 domain-containing phosphatase and tensin homolog, C1-TEN, Tensin-like C1 domain-containing phosphatase.
What is the protein family that this protein belongs to?
Belongs to the PTEN phosphatase protein family.
Protein: HIS2_MYCUA
Sequence: MKQSLAVKTFEDLFAELGDRARTRPPGSATVAALDAGVHTLGKKVLEEAGEVWLAAEHESNEALAEEISQLLYWTQVLMISRGVSLDEVYRKL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LBX1_MOUSE
Sequence: MTSKEDGKAAPGEERRRSPLDHLPPPANSNKPLTPFSIEDILNKPSVRRSYSLCGAAHLLAAADKHAPGGLPLAGRALLSQTSPLCALEELASKTFKGLEVSVLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAKKLGPSGQMDIVALAELEQNSEASGGGGGGGCGRAKSRPGSPALPPGAPQAPGGGPLQLSPASPLTDQRASSQDCSEDEEDEEIDVDD
What is the function of this protein?
Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.
What are the official names of this protein?
Transcription factor LBX1, Ladybird homeobox protein homolog 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: AIS_SHIF8
Sequence: MLAFCRSSLKSKKYFIILLALAAIAGLGTHAAWSSNGLPRIDNKTLARLAQQHPVVVLFRHAERCDRSTNQCLSDKTGITVKGTQDARELGNAFSADIPDFDLYSSNTVRTIQSATWFSAGKKLTVDKRLLQCGNEIYSAIKDLQSKAPDKNIVIFTHNHCMTYIAKNKRDAIFKPDYLDGLVMHVEKGKVYLDGEFVNH
What is the function of this protein?
Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.
What are the official names of this protein?
Lipopolysaccharide core heptose(II)-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. Ais subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: PSBL_OENEH
Sequence: MTQSNPNEQDVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: AKT1_ORYSJ
Sequence: MARWGAARMAACGPWGRNRRVGAGDAFEASEVRRDGRSRMMPACGPWGAGHGGGDPALERELSRDGSHYSISSAILPSLGARSNRRIKLRRFIISPYDRRYRIWETFLIVLVVYSAWVSPFEFGFIPKPTGALATADNVVNAFFAVDIILTFFVAYLDKMSYMLEDDPKKIAWRYSTTWLVLDVASTIPSEFARRILPSKLRSYGFFNMLRLWRLRRVSSLFSRLEKDRHFNYFWVRCAKLICVTLFAVHCAACFYYLLADRYPVPTSTWIGNYMADFHERSLWIRYVTSVYWSITTLTTVGYGDLHAENTREMIFNIFYMLFNLGLTAYLIGNMTNLVVHGTSRTRNYRDTIQAATSFGVRNQLPPRLQDQMISHISLKYRTDSEGLQQQEILDSLPKAIKSSISQYLFFHLVQNVYLFQGVSNDLIFQLVSEMKAEYFPPREDVILQNEAPTDFYILVSGSVELVEQQNGADQVIQVATSGEVVGEIGVLCYRPQLFTVRTRSLCQLLRLNRTAFLSIVQSNVGDGTIIMNNLIQFLKEQKENSVMAGVVKEIESMLARGNLDLPITLCFAVTRGDDFLLHQLLKRGMDPNESDNDGHTALHIAASKGNEQCVRLLLEYGADPNARDSEGKVPLWEALCEKHAAVVQLLVEGGADLSSGDTGLYACIAVEESDTELLNDIIHYGGDVNRARRDGTTALHRAVCDGNVQMAELLLEHGADIDKQDGNGWTPRALAEQQGHDDIQLLFRSRKAATASGHHHVPSSTTTRVAPAAAAASLIGRFNSEPMMKNMIHEDADLPSRVLPEKLRRKRVTFQNSLFGVISSSQAQRETDHPLSRGGLAATGSPNPSSGSRNAVIRVTISCPEKGNTAGKLVLLPQTLDMLLELGAKKFDFAPTKVLTVEGAEVDEVELIRDGDHLVLVSNEWDAEKMKGKS
What is the function of this protein?
Highly selective inward-rectifying potassium channel that mediates potassium uptake by plant roots.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization.  May be a major salt-sensitive potassium channel in roots.
What are the official names of this protein?
Potassium channel AKT1, OsAKT1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL13_CAEEL
Sequence: MAPRGNQMLGNAHFRKHWHKRIKTWFDQPARKLRRRQNRQAKAVEIAPRPVAGLLRSVVRCPQKRYNTKTRLGRGFSLQELKAAGISQAQARTIGIAVDVRRTNKTAEGLKANADRLKEYKAKLILFPKKASAPKKGDSSAEELKVAAQLRGDVLPLSHTITFDEPRQVTDAERKVEIFRLLRKERADKKYRGKREKRAREAAEENK
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.  As part of the LSU, it is probably required for its formation and the maturation of rRNAs.
What are the official names of this protein?
60S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF2_STRU0
Sequence: MEVAEIRQKIVENKEKLTSFRRSLDLDGLEEEIALLENKMTEPDFWNDNIAAQKTSQELNTLKSTFETFHDMLELSDETELYLEMLAEDESIKEELEEALVKLEQILSQYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWADMLFRMYTRFGNAKGFKVETLDYQAGDEAGIKSVTLSFEGPNAYGFLKSEMGVHRLVRISPFDSAKRRHTSFTSVEVMPELDDTIEVDIRDDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVASTVDRTQYGNRDRAMKMLQAKLYQLEQEKKAEEVNALKGDKKEITWGSQIRSYVFTPYTMVKDHRTNFEVAQVDKVMDGEIDGFIDAYLKWRMGDD
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_GLUOX
Sequence: MSDTTAPAFDFQDREPFWQNEWKRRNTFAVPDVPPADRPKYYVLEMFPYPSGQLHVGHVRNYTLGDVVARYKRARGFAVMHPMGWDAFGLPAENAARERNVHPGKWTMDNIATMRGTLQRLGFSLDWDREIATCLPEYYGKQQKLFTDMLGAGLVERRDSLVNWDPVDETVLANEQVVDGRGWRSGALIEKKKLSQWFLKITKFAQPLLDDLKTLDRWPERVRTMQERWIGRSEGARVRFALHQPPAGYDEDLDSVEVFTTRPDTLFGLSFIGISAEHPLARKVAESNPQAAAFIEECRRLGTSEEVIEAAEKRGFDTGLRVANPLDPEKTAPVWIANFVLMDYGTGAVFGCPCGDQRDLDFARKYDLPVPQVLLPPGQDAETFVLGKKAVSGDATLFNSGFLDGLDPAAARTKVIERLEGLGAGKGVVNWRLRDWGISRQRYWGCPIPIIHCDTCGPVPVPDEQLPVILPEDVTFDRPGNPLDHHPTWKHVNCPHCGKPAVRETDTFDTFVDSSWYFARFTSPHAETPTVPAAANGWLPVDQYIGGIEHAILHLLYARFFTRAMHETGHLDVDEPFAGLFTQGMVTHESYRDDSGWLYPEEVERQGDQVVRRETGTPVQVGRSEKMSKSKRNTVSPVDIIERYGADTARWFVLSDSPPERDMEWTAAGVAAAARFGQRLHRLVASVAARDAADSAHGATGDDLRRVTHRTIAAVGEALEAFTPNVAVARLHELTSALADAERIEGAGIAAARREAARVLCLLTAPMMPHLAEDMMAVLEPGSALVVERPWPEAEEKWLAVQSVTIGVQILGKLRGTIEVPPNAPKEEVLAAAKSEPNVARLLEGKRLVKEIHVPNRIVNFVVAG
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLB_THEBI
Sequence: MTESAMTSRAGRGRGADLVAAVVQGHAAASDAAGDLSFPDGFIWGAATAAYQIEGAWREDGRGLWDVFSHTPGKVASGHTGDIACDHYHRYADDVRLMAGLGDRVYRFSVAWPRIVPDGSGPVNPAGLDFYDRLVDELLGHGITPYPTLYHWDLPQTLEDRGGWAARDTAYRFAEYALAVHRRLGDRVRCWITLNEPWVAAFLATHRGAPGAADVPRFRAVHHLLLGHGLGLRLRSAGAGQLGLTLSLSPVIEARPGVRGGGRRVDALANRQFLDPALRGRYPEEVLKIMAGHARLGHPGRDLETIHQPVDLLGVNYYSHVRLAAEGEPANRLPGSEGIRFERPTAVTAWPGDRPDGLRTLLLRLSRDYPGVGLIITENGAAFDDRADGDRVHDPERIRYLTATLRAVHDAIMAGADLRGYFVWSVLDNFEWAYGYHKRGIVYVDYTTMRRIPRESALWYRDVVRRNGLRNGE
What are the official names of this protein?
Thermostable beta-glucosidase B, Amygdalase, Beta-D-glucoside glucohydrolase, Cellobiase, Gentiobiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_HV1B9
Sequence: MRVKEIRKNWQHLRGGILLLGMLMICSAAKEKTWVTIYYGVPVWREATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLGNVTENFNMWKNNMVDQMHEDIISLWDESLKPCVKLTPLCVTLNCTNLNITKNTTNPTSSSWGMMEKGEIKNCSFYITTSIRNKVKKEYALFNRLDVVPIENTNNTKYRLISCNTSVITQACPKVSFQPIPIHYCVPAGFAMLKCNNKTFNGSGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEDIVIRSENFTDNAKTIIVQLNESVVINCTRPNNNTRRRLSIGPGRAFYARRNIIGDIRQAHCNISRAKWNNTLQQIVIKLREKFRNKTIAFNQSSGGDPEIVMHSFNCGGEFFYCNTAQLFNSTWNVTGGTNGTEGNDIITLQCRIKQIINMWQKVGKAMYAPPITGQIRCSSNITGLLLTRDGGNSTETETEIFRPGGGDMRDNWRSELYKYKVVRIEPIGVAPTRAKRRTVQREKRAVGIGAVFLGFLGAAGSTMGAASVTLTVQARLLLSGIVQQQNNLLRAIEAQQHMLQLTVWGIKQLQARVLALERYLRDQQLMGIWGCSGKLICTTSVPWNVSWSNKSVDDIWNNMTWMEWEREIDNYTDYIYDLLEKSQTQQEKNEKELLELDKWASLWNWFDITNWLWYIRLFIMIVGGLIGLRIVFAVLSIVNRVRQGYSPLSFQTLLPASRGPDRPEGTEEEGGERDRDRSGPLVNGFLALFWVDLRNLCLFLYHLLRNLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIKIVQRACRAIRNIPTRIRQGLERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: MYB46_ARATH
Sequence: MRKPEVAIAASTHQVKKMKKGLWSPEEDSKLMQYMLSNGQGCWSDVAKNAGLQRCGKSCRLRWINYLRPDLKRGAFSPQEEDLIIRFHSILGNRWSQIAARLPGRTDNEIKNFWNSTIKKRLKKMSDTSNLINNSSSSPNTASDSSSNSASSLDIKDIIGSFMSLQEQGFVNPSLTHIQTNNPFPTGNMISHPCNDDFTPYVDGIYGVNAGVQGELYFPPLECEEGDWYNANINNHLDELNTNGSGNAPEGMRPVEEFWDLDQLMNTEVPSFYFNFKQSI
What is the function of this protein?
Transcription activator.  Involved in the regulation of secondary wall biosynthesis in fibers and vessels (PubMed:17890373).  Transcription activator of the mannan synthase CSLA9 that recognizes and binds to the DNA consensus sequence 5'-[AG][GT]T[AT]GGT[GA]-3' cis-regulatory element of CSLA9 promoter (PubMed:24243147).  Transcription factor that acts as molecular switch in the NAC012/SND1-mediated transcriptional network regulating secondary wall biosynthesis.  Is directly activated by NAC012/SND1.  Functions redundantly with MYB83 in the transcriptional regulatory cascade leading to secondary wall formation in fibers and vessels (PubMed:19808805).  Transcription activator that binds to the DNA consensus sequence 5'-ACC[AT]A[AC][TC]-3', designated as the secondary wall MYB-responsive element (SMRE).  Regulates directly numerous transcription factors and a number of genes involved in secondary wall biosynthesis that contain SMRE elements in their promoters (PubMed:22197883).  Is an obligate component of the transcriptional regulatory complex toward the commitment of secondary wall cellulose synthesis.  Is required for functional expression of the three secondary wall CESA genes, CESA4, CESA7 and CESA8 (PubMed:23726771).
What are the official names of this protein?
Transcription factor MYB46, Myb-related protein 46, AtMYB46.
What are the subcellular locations of this protein?
Nucleus.