PharMolix/UniProtQA huggingface dataset:
Protein: KCNKD_MOUSE
Sequence: MAGRGCGCSPGHLNEDNARFLLLAGLILLYLLGGAAVFSALELAQELQAKQRWEERLANFSRGHNLSREELRGFLRHYEEATRAGIRMDSVRPRWDFTGAFYFVGTVVSTIGFGMTTPATTGGKIFLIFYGLIGCASTILFFNLFLERLITVIACVMRSCHQQQLRRRGAVTQDNMKAPEKGEADSLTGWKPSVYYVMLILCLASVAISCGASALYTTMEGWSYFDSVYFCFVAFSTIGFGDLVSSQNAQYESQGLYRFFNFFLILMGVCCIYSLFNVISILIKQTVNWILRKLDSGCFPPCQRGLLRSRRNVVMPGNIRNRCNISIETDGVMESDTDGRRLSGEMISMKDTNKVSLAILQKQLSEMANGGPHQNSASSRDDEFSGGVGAFAVMNNRLAETSGDR
What is the function of this protein?
Potassium channel displaying weak inward rectification in symmetrical K(+) solution.
What are the official names of this protein?
Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited potassium channel 1, THIK-1.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HM08_CAEEL
Sequence: MSNPTDNNSATSSITPNFSAFSSFTTYKPSDSFSSFESDSSPSKSSSSRKNRDKIADKKQRRNRTTFTTFQLHALEAAFDKTHYPDVYARETLAAKVQLPEVRVQVWFQNRRAKFRRQEKQDCQGEEKHSLKDTMPSWSWMSENKTDTPPMLPPANTLSSTHNNGISDEFFKTSEGKEVYGFPFAEYGTPADNTHVSKTGNVFHLNFEDSDKKSMKKESPQTPSTSSPFISEYHPPFIPYYIPNQSFSNAFNQYPMPFPYPIHFEPPQLTHSQENC
What is the function of this protein?
Required for cell specification of the RIA interneurons.
What are the official names of this protein?
Homeobox protein ceh-8.
What are the subcellular locations of this protein?
Nucleus.
Protein: RAX2_YEAST
Sequence: MFVHRLWTLAFPFLVEISKASQLENIKSLLDIEDNVLPNLNISQNNSNAVQILGGVDALSFYEYTGQQNFTKEIGPETSSHGLVYYSNNTYIQLEDASDDTRIDKITPFGVDSFILSGSGTINNISVGNQILYNLSTLSMTPIFNQSLGAVQAVLADNSSIYFGGNFSYNNGSMTGYSALIWDSISNTTQLLPFGGFGENSSVNSIVKLNNDNILFAGQFYTLDDPSALISSSNNGTNSTSSLNATTLELGQRIPLRYASWDSQGSTTFASDSLVCPNTNEDAWLYPDTSGSLVCNLPYEVSPTKIRLYNSQRSDSEISVFQILTDPSSSIMNLTYLDPLSGELKNCGEFCPLYSRATLLSASQNVSSSMDMITFIDNNKTDVKWTSDFQDFAFVNELPVSSLKFVALNSYGGSVGLSGLELYQDTFSTYANDSLNEYGCSALTNDSSSSTLSSNDWYNGLTGESYIAAKYVPDQNEPIPRVKFYPNIIHPGHYTINMYTPGCLQDNTCSARGIVNVTMWNQQNNTIMKTYLIYQNNDNLKYDQIYSGYLDFSPEIVLEYVSGIYTTNTATVVVADQVNVITVSLDAFNTLSDSSNAKKETLLNGILQYQKSNFTSTRLNETKVGNTTLNLFPVKNYPKNSSLYADIYDNKLVIGGVSNRISIVDLNDDFEVTSSKNQTIQGDVHGITKTNQGLLIFGDILSSNNQSAVFLFNGSFENVFNQSRTVNSALNISLANNDFIVLDNDYVVNASSNALIRNSSSFSLSLWAAGNNGDGDVLFSGAVSHMQYGNLNGSVRFLNENEIEPLNLEGGIVPYLGAYLNESATAYAYEVDSLNKIYFSNEVYPSWNWSSGITQMLYADNQTLLAVSAGSSTTAELSIFDLRNLTMIANETLGSNARINALVNFEKNCSMLVGGDFQMTEPNCTGLCLYNYESKTWSTFLNNTIFGEITQLSFTNSSELIISGLFETKEYQSIRLGSFNLTNSTMIPLLSGSEGKLNSFTVTEDSIVAWNDTSLFIYRNQEWNITSLPGNASSISSVSAIYTDIESNTLNKRGINNVNNGSILLLNGNFNISQYGYLQSLLFDFQKWTPYFISETTNTSNYNPIIFINRDVSTEFNSQSPLANVNITVTSPQSTSSQPPSSSASSESKSKSKKKKIGRGFVVLIGLALALGTVSVLGIAGVILAYVFKDPEGDYKPIKPRIDENEMLDTVPPEKLMKFV
What is the function of this protein?
Required for the maintenance of the bipolar budding pattern.  Involved in selecting bud sites at both the distal and proximal poles of daughter cells as well as near previously used division sites on mother cells.
What are the official names of this protein?
Bud site selection protein RAX2, Revert to axial protein 2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Bud neck. Bud tip. Note=Before cytokinesis, RAX2 concentrates as a ring at the mother-bud neck and to the tip of the bud. The RAX2 ring splits at cytokinesis, endowing each progeny cell with a RAX2 ring and additional RAX2 localization at the distal bud pole of the newborn daughter cell. The rings persist at the cell cortex for several generations, giving rise to cells decorated by multiple rings.
Protein: ERF1Y_ARATH
Sequence: MAEEADTNIEIWKIKKLIKGLESARGNGTSMISLIMPPRDQVSRVTKMLGDEYGTASNIKSRVNRQSVLSAITSAQQRLKLYNKVPTNGLVLYTGTIVNDDGKEKKVTFDFEPFRPINASLYLCDNKFHTEALNELLESDDKFGFIVMDGNGTLFGTLSGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKTAELATQFYINPATSQPNVSGLILAGSADFKTELSQSELFDPRLQAKILNVVDVSYGGENGFNQAIELSAEILSNVKFIQEKKLIGKYFEEISQDTGKYVFGVEDTLKALEMGAIETLIVWENLDINRYELKNSTTGEMVVKHFGKDQESDTSNFHDSETNAELEVQEKMPLLEWFANEYKRFGCTLEFVTNKSQEGSQFCRGFGGIGGMLRYQLDMRTFDELSDTEVYEDSD
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:15474304).  Modulates plant growth and development (PubMed:16113224).
What are the official names of this protein?
Eukaryotic peptide chain release factor subunit 1-2, Eukaryotic release factor 1-2, eRF1-2, Omnipotent suppressor protein 1 homolog 2, SUP1 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_STAS1
Sequence: MLKPLGNRVIIQKSEQEQTTKSGIVLTDSAKEKSNEGTIIAVGAGRILKDGSRVAPEVNEGDKVVFQQYAGTEVKRGDETYLIVNEEDILAIIES
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_YEREN
Sequence: MSEPEYRGNSFTGSRHALGINAPELAQYQDEPAQMRRRGVGKSGYLKLRFAKREHRSILAEMERRVPSMVQKALYWDEEMPELPCVTMISTSGCILQGDRLATDVIVEAGACAHVTTQSATKVHMMNANYASQIQNFTVEEGGYLEFMPDPLIPHRNSRFITDTTINIHPTATAIYSEVLMSGRKYHHADERFGFDVYSSRVAAHVFLGKEQPAGKELFVEKYVLEPKSESLDAIGVMQSFDAFGNVILLTPKEHHERILARVPAHFDIKGGIASGATRLPNDCGLVFKALGIDSAGVKNEIRQFWKIAREEILGVTLPEKFLWR
What is the function of this protein?
Expression of the urease operon increases the likelihood of bacterial survival by contibuting to acid resistance in vitro and in vivo in BALB/c mice.  Y. enterocolitica enters the body via an oral path and must survive the acidic stomach before being able to colonize the intestinal mucosa (PubMed:7558281).
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARL4A_BOVIN
Sequence: MGNGLSDQTSILSSLPSFQSFHIVILGLDCAGKTTVLYRLQFNEFVNTVPTKGFNTEKIKVTLGNSKTVTFHFWDVGGQEKLRPLWKSYTRCTDGIVFVVDSVDVERMEEAKTELHKITRISENQGVPVLIVANKQDLRNSLSLSEIEKLLAMGELSSSTPWHLQPTCAIIGDGLKEGLEKLHDMIIKRRKMLRQQKKKR
What is the function of this protein?
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).  GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.  Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 4A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding.
Protein: ATPE_MANSM
Sequence: MTTFNLTIVSAENKIFEGAVKSVQATGIEGELGILAGHTPLLTAIKPGIVKFTYNDGIEEVIYVSGGFLEIQPNIVTVLADVAIRGSDLDQDRILAAKKKAEDNIVAKSGDLNHEMLTAKLSKELAKLRAYELTEKLVKNKR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: XERDL_STRP8
Sequence: MKSYIEPFIASKALSQNSQKAYRYDLQQFCQLVGERVNQDKLLLYQNSIANLSLSAKKRKLSTANQFLYYLYQIKYLNSYFRLTDTMKVMRTEKQQAAIINTDIFYQKTPFVWGQLISLLILELGLTPSEVAGIEVANLDLNFQMLTLKTKKGVRVLPLSQILIPFLEQQLVGKEVYLFEHRGIPFSRQWFFNHLKTFVRSIGYEGLTAQKLREQFILKEKLAGKSIIELSDILGLKSPVTLEKYYKS
What is the function of this protein?
Putative tyrosine recombinase.  Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site.
What are the official names of this protein?
Tyrosine recombinase XerD-like.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD-like subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCHB_CHLPM
Sequence: MRLAFWLYEGTALHGISRITNSMKGVHTVYHAPQGDDYITATYTMLERTPEFPALSISVVRGRDLAQGVSRLPATLQQVEHHYHPELTVIAPSCSTALLQEDLRQLAAHSGVAQEKLMVYAVNPFRVTENEAADGLFTELVKRYAANGQKSAVPAVNLLGFTSLGFHLKANLTSLRRMLSTLGVKVNVVAPWGAGIADLARLPEAWLNIAPYHEIGRTAAEYLEQEFAMPAVYDTPIGVEPTLRWLRSIIEKLNEVGAGCGASPISMPALHDFSLDGMSAPSGVPWFARTADMESFSNKKAFVFADATTTVAMVKFLRDELGMKVVGAGTYLERDADWVRRELEGYLPGELMVTDRFQDVAKVIEDELPDLVCGTQMERHSCRKLDIPCMVVSPPTHIENHLLGYYPFFGFDGADVIADRVYLSCKLGLEKHLIDFFGDAGLEYEDGDAADETGVAAAAANGHSPAGGSTEGEGGMVWTGEAETMLKKVPFFVRKKVRKNTETFAMEQGEGEVTVEVFRRAKDSLGG
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (BchN-BchB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: BAME_SALTY
Sequence: MRCKTLTAAAAVLLMLTAGCSTLERVVYRPDINQGNYLTPTDVAKVRVGMTQQQVAYALGTPMMTDPFGTNTWFYVFRQQPGHENVTQQTLTLTFNSSGVLTNIDNKPALTK
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamE.
What is the protein family that this protein belongs to?
Belongs to the BamE family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: EI3G2_DROMO
Sequence: MKPTITSWADEVEADYVDGLPPSKEHVDGDYKHVTEYKFNDEGKKIKVVRSFKIEKKIVSRAVAKRRNWTKFGDSKLDKPGPNSYTTKVADEILMNYMGSKDFEHTQDPLDASKPIAKCRICNGEHWSVKCPYKGTSMDIESKAIAAATAAVGETNKAGKYVPPFLKEGGKGRERDDSSAVRISNLSESMTEDDLEELVKKIGPHTKMYLAREKNSGLCKGFAYVHFKYRKDAAEAIEILNGHGYDHLILSVEWSKPQN
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  This subunit can bind 18S rRNA.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit G-2, Eukaryotic translation initiation factor 3 RNA-binding subunit 2, eIF-3 RNA-binding subunit 2, Eukaryotic translation initiation factor 3 subunit 4-2.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit G family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPMPJ_MACPH
Sequence: MLQLILHHPYASLAAGILLYFFCLATYRLYLSPVAGFPGPRLAALTRFYEYYYDGVKGGQFVWKVKDLHQKYGRLSCSTVVGQELKLEQGPIVRIGPCELHVNDPTFVSTLYPATGQRRNKDPFWTDQFGPKTAFGTVDHDHHRLRRGPFNRFFSKANVTRLEPMLRQQANKLCEKLEKYAGTGRVIDLSDPFGCMATDIISTYALGYSFNFLDAEDFQPNLLQGLNGFTPLAPTVKQFPWLLKLLRALPDSWALKINPKIAPFLDFQRTMKKVITDVEAEVQSEAGRPKADQATTIFHEVLRGDIPPEEKETARLWQEGEAIIGAGTFLQTPQEAV
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpmpA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpmpD through the action of the prenyltransferase dpmpC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpmpE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpmpB (Probable).  The short chain dehydrogenase/reductase dpmpG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpmpH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Higginsianin B is further methylated by the methyltransferase dpmpI to produce the intermediate named FDDP B (PubMed:32286350).  The cytochrome P450 monooxygenase dpmpJ then oxidizes the C-26 methyl to primary alcohol, producing the final diterpenoid pyrone with a C-26 primary alcohol on the gamma-pyrone moiety named FDDP C (PubMed:32286350).
What are the official names of this protein?
Cytochrome P450 monooxygenase dpmpJ, Diterpenoid pyrone biosynthesis cluster protein J.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RSMG_ECOL5
Sequence: MLNKLSLLLKDAGISLTDHQKNQLIAYVNMLHKWNKAYNLTSVRDPNEMLVRHILDSIVVAPYLQGERFIDVGTGPGLPGIPLSIVRPEAHFTLLDSLGKRVRFLRQVQHELKLENIEPVQSRVEEFPSEPPFDGVISRAFASLNDMVSWCHHLPGEQGRFYALKGQMPEDEIALLPEEYQVESVVKLQVPALDGERHLVVIKANKI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_STRZP
Sequence: MNFETVIGLEVHVELNTNSKIFSPTSAHFGNDQNANTNVIDWSFPGVLPVLNKGVVDAGIKAALALNMDIHKKMHFDRKNYFYPDNPKAYQISQFDEPIGYNGWIEVKLEDGTTKKIGIERAHLEEDAGKNTHGTDGYSYVDLNRQGVPLIEIVSEADMRSPEEAYAYLTALKEVIQYAGISDVKMEEGSMRVDANISLRPYGQEKFGTKTELKNLNSFSNVRKGLEYEIQRQAEILRSGGQIRQETRRYDEANKTTILMRVKEGAADYRYFPEPDLPLFEISDEWIEEMRTELPEFPKERRARYVSDLGLSDYDANQLTANKVTSDFFEKAVALGGDAKQVSNWLQGEVAQFLNAEGKTLEQIELTPENLVEMITIIEDGTISSKIAKKVFVHLAKNGGGAREYVEKAGMVQISDPAILIPIIHQVFADNEAAVADFKSGKRNADKAFTGFLMKATKGQANPQVALKLLAQELAKLKEN
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: TKN4_HUMAN
Sequence: MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWVIVALEEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQLEHTFQGLLGKRSLFTEGREDEAQGSE
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.  Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats.  These effects are suppressed by treatment with endokinin-C.  Endokinin-A/B reduces arterial blood pressure and increases sperm motility.
What are the official names of this protein?
Tachykinin-4, Preprotachykinin-C, PPT-C.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YDJE_ECOLI
Sequence: MEQYDQIGARLDRLPLARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWFLSGKYFIESPRWLAGKGQIAGAECQLREVEQQIEREKSIRLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIETRKVSLEEISEVN
What are the official names of this protein?
Inner membrane metabolite transport protein YdjE.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SSN3_COCIM
Sequence: MSFSNLPPSSGRGSHADGASGRSMPPFPGSSSFTANNPSKGIHPNLTLKRSVQSFDESLDNKKPLPFSYASKVKLREKYLIVGFISSGTYGRVYKAKGRDGVGGDFAIKKFKPDKEGEKVEYTGLSQSAIREISLCTELNHPNVVRLVETILEDKCVYMVFEYTEHDLLQIIHHHTQPQRHAIPAPMVKSILFQLLNGLLYLHSQWVMHRDLKPANILVTSKGAVRIGDLGLARVFKKPLNSLFSGDKVVVTIWYRAPELLLGARHYTTAVDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMLKIIEILGLPKKEKWPGLSSMPEFPQLQAMAMAPGSGHLHKPSNLEHWYHVCLKSGGYSGSSPAGSPGKEGFDLLSRLLEYDPEKRISAKEALNHPYFTTGTPVAKNCFEGFEGKYPNRRVSQDDNDIRSGSLPGTKRSGLPDDTLTSRAAKRAREM
What is the function of this protein?
Component of the SRB8-11 complex.  The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase SSN3, Cyclin-dependent kinase 8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRMA_SERP5
Sequence: MTPENLPIERYDDQLAEKTARLKTLMSPFTAPEPEVFRSPVSHYRMRAEFRIWHDEDEMYHIMFDQQTKQRIRVDKFPAASELINRLMSALIAAIKPEPILRRKLFQIDYLSTRSGKIIASLLYHRKLDDEWQQQAEKLRDDLRAQGFDLQLIGRASKMKIMLDQDYVDEVLPVAGRDMIYRQVENSFTQPNAALNIQMLEWALDVTTGSKGDLLELYCGNGNFSLALARNFERVLATEIAKPSVAAAQYNIAANQIDNVQIIRMAAEDFTQAMNGVREFNRLKGIDLSSYNCETIFVDPPRSGLDDETVKMVQAYPRILYISCNPETLCANLETLQQTHSISRLALFDQFPYTHHMECGVLLEKRV
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: FABA_SACD2
Sequence: MQAFEQKSSYERAELITCGQGNMFGPGNAQLPVPNMLMLDRISHISQTGGEFGKGEIIAELDITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLAWKGNAGRGRALGAGEVKFTGQILPTASKVTYHINLKRVIERKLVMGIADGRVAVDGKEIYFAKDLRVGLFTNTDSF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTAP_MYCS2
Sequence: MMLGVIGGSGFYTFFGSDARAVSVETPYGPPSAPITVGTVGDHEVAFLPRHGVKHEFSPHTVPYRANLWALRSLGVRRVFAPCAVGSLTPDLGPGSIVVPDQLVDRTSGRDDTYFDSGGIHVAFADPYCPTLRAAATGLPGVVDGGTMVVIQGPRFSTRAESRWFASQGFTLVNMTGYPEAVLARELEMCYAAVALVTDLDAGIEVGSGVRAVDVFAEFERNMPPFKKLVFEALEAVEVERTCTHCLTHSGVQLPFELP
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein: KA232_VAEMS
Sequence: AAAISCVGSKECLPKCKAQGCKSGKCMNKKCKCYC
What is the function of this protein?
Selectively and irreversibly binds (K(d)=2. 9 pM) and blocks Kv1. 3/KCNA3 potassium channels of human T-lymphocytes.  Weakly blocks Kv1. 2/KCNA2 (9%).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 23.2, Toxin Vm23, Toxin alpha-KTx 21.2.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 23 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CPAR_ASPOZ
Sequence: MPETHQNTLTWKGTRLPAGEACNGCRERKRRCVRRKRELPCLSCQAENRPCDVSRYRRRRRRRRGPNKRNCKSLRVLGGQSAEPFNMHQQPDTDSCSEIQHGIETDECGSQCRIPSQSPGPYPEPQPAASTYSLCLPSYVTGVPKHLALVTLNALREKGAFTLPPAEIQTYLISSYIMHVHPDMPFLDLERLLEAVILRCRGRQTSMLLLQAVMFAGSIFLDPVYLHLMGYTSRRAAMRDLFGRAKLLYECGFEVQPTYKLQSLLLFTLFHEDDLAGSSFWMGEAWNLAKTIGLQYDLQEVPVDESSSELAFRRRLWWCVYTRDRLLALSTRSAMHISDGDYNVPMLALADFKSCFGTAEAYRALQLDSDLRTDGTKTALALTFIYKTKLSQLIGRVLMSQYTIGSASPTTMLYYPRPTPISLSDFLGMENDLDVWETSLPSLLEFPLPLLSPVSQAEKIIYAQRAMLHMIYLTCINALHRPWSSSAQPTSSDPWEGAFRDLSAWKIEYASQAILMIATHLHSIGLTNFLADTAVPSLLSAMITHIVRLNSDILVAPEANAVCFVQGWECLQGLREKYEWARHAAAFIRFTTRSLRTG
What is the function of this protein?
Transcription factor; part of the gene cluster that mediates the biosynthesis of the fungal neurotoxin cyclopiazonic acid (CPA), a nanomolar inhibitor of Ca(2+)-ATPase with a unique pentacyclic indole tetramic acid scaffold.
What are the official names of this protein?
Transcription factor cpaR, Cyclopiazonic acid biosynthesis cluster protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: VKBH2_BUNCA
Sequence: MSSGGLLLLLGLLTLWAELTPVSSRKRHPDCDKPPDTKICQTVVRAFYYKPSAKRCVQFRYGGCNGNGNHFKSDHLCRCECLEYP
What is the function of this protein?
Beta-bungarotoxin is a presynaptic neurotoxin of the venom.  The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic (By similarity).
What are the official names of this protein?
Kunitz-type serine protease inhibitor homolog beta-bungarotoxin B2a chain.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.