PharMolix/UniProtQA huggingface dataset:
Protein: CY041_POSPM
Sequence: MDSSTSLLPPLGSIILACEGLTSLVPLILSVMVCLIATVTISPTLLAYFNDPFELRAYPGPFLARFTSAWISWIISQNRWSETVDLMHRQHGPIVRLSPDHVSVASPAAFAAVYGHSSGALKAPFYNAFANFKIRSIFNTRDRAEHSRKRRVEAHMFSPRSIRALEDTARVHFQVLVRQWDALCAPTGKTVRGSAEGTLGTISWKVHGDRVWFDCMPWFNFWSFDTISDLAFGRPFGMLEAAKGSAHVSKSNTKSVQAVSQDTSHSNEAQSELLEIPAMEVLSELLDFTVALAYLPAWVQPVFGRLPMFRDGYDAAPKLANLSLTAVANRVASQTDRADMLSELLRGRDEEGKPYGLEELSTEAELLIIAGGDTTANTSCATAYYIARDLQIQAKLQAELDVALDGVESDVAPYDAVKDLPYLDAVINEGLRLHSTIGAGLPRVVPSGGMTVLGQHLKEGTVVSSPIYTLHRNEAVWGKNAYEFYPERWLEASADAKKEMMQSFAPFSVGPRACLGRSLALQQLHILLATIFHRYSLVLENNAPAQLPLRDGFARKPMKCIVGVQRRK
What is the function of this protein?
Cytochrome P450 monooxygenase that is able to use 3,5-dimethoxy-trans-stilbene and 3,5,4'-trimethoxy-trans-stilbene as substrates for oxidation.
What are the official names of this protein?
Cytochrome P450 monooxygenase 41.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TRMD_THEFY
Sequence: MRIDIITIFPDYFTPLDLSLIGKARRSGLIDVRLHDLRRWTYDRHHTVDDTPYGGGPGMVMKPEPWGEALDEITADADAGTPRLILPTPSGLPFTQQDAVRLAKEPWLIFACGRYEGIDARVAVDAAQRMPVEELSIGDYVLNGGEVATLVIVEAISRLLPGVLGNVESITQDSFAPGTMDNLVEGPVYTKPPVWRGHEVPPILLSGHHAAIDRWRRDEALRKTARNRPDLIRRLDPESLDKRDREVLAEVGLQETSEPVAD
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AB7I_ARATH
Sequence: MAAATVLGRLSLIPNLSSKPKLKSNRRTTSTSVSVRAQASFSDPFVLQLAESLEDSLSASPSSSLPLQRIRDSSAETLLSTPWPSRKDEPFRFTDTSLIRSSQIEPISTQQRNSEILDNLTETQFTNAVIIDGFVSNLTIGPSDLPDGVYFGKYSGLPDELTNRISEFIGNFDSGDLFWSINGMGAPDLMVIYVPEGCKVENPIYLRYFSGETGDRESKRLPVSNPRVFVLVEEGGEIGIVEEFVGKDEEGFYWTNPVLEVVVQKNAKLKHSYLQKESMASAHIKWTFVRQEAESEYELVEVSTGGKLGRHNVHVQQLGPDTLTELTTFHMCVNEQTLDLHSKIILDHPRGASRQLHKCIVAHSSGQAVFDGNVRVNRFAQQTNAGQLTRSLLLKPRATVNIKPNLQIIADDVKCSHGAAISDLEEDQLFYFQARGIDLETARRALISSFGSEVIEKFPNREIRDQARNHVKGLL
What are the official names of this protein?
Protein ABCI7, chloroplastic, ABC transporter I family member 7, ABC transporter ABCI.7, AtABCI7, Non-intrinsic ABC protein 6, Plastid SufD-like protein.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CTSD_ARTOC
Sequence: SLIDTGASRTWVFGSDCTSKSCGAHNTFGKEDSKTIKVTDEKWDVAYGTGKVAGVIVNDTMSFAGFELDTPFGSATTASDDFMSYPMDGILGIGPQDSKAKVPTVIQLLMQQKLLKSNIIGINLQRNSDGATDGQITFGDVDKSKFSGELAYSNVVSGGYQWEIAVDDIIVDGKPLNFQGRSGIVDTGTSFLLLPPDDADLIHSKIPKSAKSSVFYTVPCSTTTNIELSISGVKYAIKPKDYVGYESTTKGICNSLIIGRQAIGPKQWLLGDVFLKNVYSVYDFDKNRVGLAARKYGETKDPPSSSHPPPAPTSNKASGGSPGLPEQSGTSSATTSTTGEPSSGSTASPSAASSVSMSAWLSLAVFLSTASSLILWD
What is the function of this protein?
Secreted aspartic-type endopeptidase which is secreted and contributes to virulence.
What are the official names of this protein?
Probable aspartic-type endopeptidase CTSD.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: THIC_CLOBK
Sequence: MNYTTQMDAAKKGIVTKEMEIVAKKENMNVKDLMKLVSKGKVAIPANKNHKSLDPEGIGQGLRTKINVNLGISKDCYNIDMELEKVQKAIDMKAEAIMDLSCFGKTEEFRKRLIDMSPAIIGTVPIYDAVGFYDKELKDITSEEFLKVAEKHAENGADFLTIHVGMNRKTAATFKKNPRRMNIVSRGGSLLYAWMELNNKENPFYEGFDKLLDICEKYDVTLSLGDACRPGCIEDSTDASQIEELIALGELTKRAWERNVQVIIEGPGHMTLDEIETNMKIEKKLCHGAPFYVLGPIVTDIAPGYDHITSAIGGAIAATHGADFLCYVTPAEHLRLPNLDDMKEGIIATKIAAHAADLAKGVKGARDWDNAMAKARRDLDWERMFELSIDEEKARRYREESKAKSKDSCTMCGKMCAVRNMNRVTEGKDLNMLRDDD
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: TI214_ZYGCR
Sequence: MITIAPMLFSVLRAYDLACINTAGPLIILGIYYGFLITLPIAPSQLVCIRAFLLEGEGKESESPGTVAKSGILIAAISGLTVSQLAFFLSIYWPPLYMIWLKPHLLTLLVLPYMFFYWSRIQEFESSGWLKTEQSKIYDPRVRAAFLDSFLFQALNPVLLPSPVMTRLMSVFLFRYSQVSLFILGTAIGWLGGQIMFVLLSWCLLLRLERDLPTIYVIVRRLVHNIFPPIVFGLCLAYMGRAPVSFFRKQTDIQQMPEIRPTELWPSVAFDTTLWKRPFRLPKKDMLDNFPPLYNNKKRFSQYLFEVCVSEGKRRLSYTYPQSLLAFQSHLEDCLDVTYVSQQTDNDIYHEWATSKQNRKDQISNILLKQMEALDNGAPIETVIENKIASLTTIEQPVRKRLDPRLAKYMRYNTLSNKTESPWIQGESSVLEDTSLELQSKPNLFHLTENNYLREWISIKSEQMINTLILPWQSLEHDSDAALLTLLNNSPETNINKEQLYTWESLLHAYKLNPKVDIYKTMPGHKKLLYYLTKQPVTKLLTQIFHMDQRVDSSDIKTLLDYYKPLPVWYAQRHFTTTDIRQPRISKRLKSFDFVRRLITGSLRARRRNTLIWNALQIKPETPFLLRVHNVSKQEDMSIKQAISVTTQQTNLYASETAKRFNFRLAHMVRSPALVIQSWFRKYVKQPILILFKNVGRLLLLQKTEWSEDIGDWAREVYIYYSYDGKQYSITERPKKWYYTGLQIRILFPFHLRPWHPSNATADGKDKINLQLQSDFDLVNNNNSILEHSSYLTVWGSETEVAFGNVKKKPSFWKPTFKAIRLVLSRKLNKQFVKIGNMFQPVYKLVQTPLSSKFVNQTMFAQEEPSVSDNMKHNTIEQPINSIDNKNLFFLNHNKDNKATKNVLSIEKSSLILSDNRASQDSLVLSSDSNKLYTNEHKLENTSKQLLVIKSEHTKPLQQPIMLFRIKPILEANTIIKHSLIGRPPMQTNQKSVDNFQVQLLSKESSISIRYKLTQFNSLLVQFQRTWIYIKQNIQNIIVELFKFIQLQFTETRMTILHLIQQLMQLVSSQVITGFRTISSGIDHLFDSYYIWRMKHFTAKHLQNVYETTPIDSSSITQAYILNKIWQSIIESTPNLSWVTQQWTSENRLQDYLQTQLVDQGILNCQEPNKLTQANWNKWLEFFPQYIPSSNIWLNVIPNRYRSEVNLYWKYCDNIDYKNKHPIVSINAHNKIQQSNGLRYHTPLLQKLEKLSKRWKMYNLYRRYTSFVNNINTNRFPTEPILSNELNQLNYVNENIVHNSVNKTEETISYREPIEWGFTRTRLGRFSPYLTLSQSHSNNSIDDIDTEDIETLGLFAILQTYKEFNKKTNFTSSSVDHKLHKQESSAAPKIDHKLDSQLVSTNLIQRTCFEPMYASKLKSKLLKERFKNLLNAARLSILATKSGVTTDTTTFLSSNMQRDLSILTEDLNTHKDINEGIEISEETKQDAYSKAMRNSVLFKQNLQNWRLKIMDDQIFMYNMVSPILRLSNREHNDYILNLCNCLLGELSSNLVESIVALTPEDILLPTSSRELRVLDCLDLTAGPNDYQSVSNNTLIQNKTNSIAVTDQILQNKSKLSYSNFVSNIQQKSKPSYIIKRFLWPTYRLEDLACMNRFWLSSGNQSRFSALRISMYPSMLE
What is the function of this protein?
Involved in protein precursor import into chloroplasts.  May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
What are the official names of this protein?
Protein TIC 214, Translocon at the inner envelope membrane of chloroplasts 214, AtTIC214.
What is the protein family that this protein belongs to?
Belongs to the TIC214 family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: LPXD_ACIAD
Sequence: MNIPHYSLETLAHLVQGELFGDEHFNLSGLASLEQAQSHHISFVNGEKYVEAAKQSKAGALIVTSAFKDQLPASQNYIVVKNPYLAFAQLTHVFEKKMTQRGIESTAKIHPSAMIADNAYIGHYVIIGAECVVGENTVILAHSFLGDNVEIGRDGFVESNVSLLQGTKIKDRVRIHANTVIGSEGFGFAPYQGKWHRIVQLGTVQIGHDVRIGSNCSIDRGALDDTIIEDGVIIDNLVQIAHNVRIGSNTAIAAKCGIAGSTVIGKNCILAGACGVVGHITITDNVTLTGMSMVTKSISEAGTYSSGTALMENNQWKRTIVRFRQLADVPLTQIMKRLDHIQTQIESLESTFKLRK
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: CUC3A_HAECO
Sequence: MDVIDHRIKAYRFVAYAAVGFSVVAVLSVCVTLPIVYNYVHYVRKSLHKEASLCKISTNSVWDDVTVLRLAHFGNRTARQAITSSEENGGCESCCRPGPPGPPGPPGRPGRPGRPGAPGLPGVPGLPPPDGSCEPVSIPPCAECPAGPPGPPGKPGPPGDPGEDGQPGPPGQDGIPGQQGTKGPPGPPGIPGKPGESGEVGEDAECEPVAPGDQGPPGEPGPEGPPGEPGLQGPVGMPGQVGQKGESGSDGQLDFDGSPGRPGPPGPPGRPGEPGICPKYCAIDGGIFFEDGTRR
What is the function of this protein?
Nematode cuticles are composed largely of collagen-like proteins.  The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.
What are the official names of this protein?
Cuticle collagen 3A3.
What is the protein family that this protein belongs to?
Belongs to the cuticular collagen family.
Protein: GRPA_RAT
Sequence: MLVVLLTAALLALSSAQGTDEEVNNAETSDVPADSEQQPVDSGSDPPSADADAENVQEGESAAPANEEPPATSGSEEEQQQQEPTQAENQEPPATSGSEEEQQQQEPTQAENQEPPATSGSEEEQQQQEPTQAEDQQPPATSGSEEEQQQQESTQAENQEPSDSAGEGQETQPEEGNVESPPSSPENSQEQPQQTNPEEKPPAPKTQEEPQHDSGRPKKPLLPFIANLIRERIRKLLARSPLGRRF
What is the function of this protein?
GRP proteins have a marked affinity for hydroxyapatite.  They may play a role in the formation of the protective acquired pellicle at the saliva-tooth interface.
What are the official names of this protein?
Submandibular gland secretory Glx-rich protein CA, GRP-CA.
What are the subcellular locations of this protein?
Secreted.
Protein: RL2_LISMF
Sequence: MAIKKYKPTTNGRRHMTSSDFAEITTSTPEKSLLRPLKKKAGRNNQGKLTVRHHGGGHKRQYRVIDFKRNKDGIPGRVATIEYDPNRSANIALINYADGEKRYIIAAKGLEVGQTIYSGAEADIKVGNALELKDIPVGTVIHNIEMKPGKGGQLVRSAGTSAQVLGKEGKYVLIRLNSGEVRMILATCRATIGQVGNEQHELINIGKAGRSRWMGKRPTVRGSVMNPNDHPHGGGEGKAPIGRKSPMSPWGKPTLGYKTRKKNNNSDKFIVRRRKKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PUR8_STAAS
Sequence: MIERYSREEMSNIWTDQNRYEAWLEVEILACEAWSELGHIPKADVQKIRQNAKVNVERAQEIEQETRHDVVAFTRQVSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEKDLERFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEIEVGKMSGAVGTFANIPPEIESYVCKHLGIGTAPVSTQTLQRDRHAYYIATLALIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRGYITTAYENVPLWHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNIDKTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITSVLTKEELDECFDPKHHLNQVDTIFERAGLA
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: MUTS2_LACE2
Sequence: MNKKSLSTLEFYKITDQLVSYACCDGAKKILRNLKPMTDITDINLRLNETNDALSRIFQKGTVDFSQTKDIRASVARLKVGSSLNISELLNISAILSCAKHVKDYYEHREDSISGMLENLATVDALNSQIKKCIISEDEISDDASSNLRSIRRSKSIANDRIHSELNKLLNSPTYRTYLQDYVITTRQGRYCLPVKAEYKSAFPGMIHDQSSTGSTLFIEPAAVVKLNNDIRELELKEAAEIEVILADLSAKAGEHTEELLCDYEILVELDCIFAKAQLARHMHASRPVMNTSGIINIKKGRHPLIESHTVVPIDIYLGTDFKLLIITGPNTGGKTVSLKTVGLLTLMAQSGLFIPALDHSDIAVFKNIYADIGDEQSIEQSLSTFSSHMTNTVKILKEADENCLVLFDEIGAGTDPTEGAALAIAILNDLKMRGVTTMATTHYSEIKLYALSTEGVENASCEFDVESLRPTYRLLIGIPGKSNAFAISKKLGLPDYILSDASERLNAEDVHFEDIVSDLEHARISLEKEQAEVESYKAEIASLKEKLQAKNERLDERTDNIIRKANEQAAAILKDAKDFADETIKAMNKHGMTVAELEKHRTAVREKMNKNQAKLKVEPAKVKAHKAHDISEFKTGMHVKVLTMNVSGTVSAIHPAKKQVTVQVGALSTKIDIKNLEILSDYKEPKEAPSKAAGGSGKIKMSKSAGISTEINLLGCTVDEAVARLDKYLDDAYIARIPQVRIVHGKGTGALRNGVTAYLRGVPYIKSFRLGEIGEGDAGVTIVDFK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: ISPE_RUBXD
Sequence: MRGSLRVRAFAKVNYALEVLGRRADGYHEIRTVLQSVSLWDELEISGPEGRFGLVVEPEGAGVGPERENTVYRAWRLLAGEAGAPPVRVTLRKGIPAGSGLGGGSADAAALLWGANELLGLGLGEADLAALALRVGADVPFCLVGGTALGEGVGERLFPLPAPPEHRLVVAMPPRGASTAEVYGAYGGLGGAAPGGWSGRVVRALRAGDLGALGAAVGNDLTPVTAGLAPEVEKLLAGLREAGALGACMSGTGSAVYGLFREEAAAHEAARRLGGAAFVRVCRPVGRGLAGG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: HHAT_HUMAN
Sequence: MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPALPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIQDSLARYFSPQARRRFHAALASCSTSMLILSNLVFLGGNEVGKTYWNRIFIQGWPWVTLSVLGFLYCYSHVGIAWAQTYATD
What is the function of this protein?
Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (PubMed:18534984, PubMed:31875564, PubMed:24784881).  It also catalyzes N-terminal palmitoylation of DHH (PubMed:24784881).  Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs (PubMed:31875564).  It is an essential factor for proper embryonic development and testicular organogenesis (PubMed:24784881).
What are the official names of this protein?
Protein-cysteine N-palmitoyltransferase HHAT, Hedgehog acyltransferase, Melanoma antigen recognized by T-cells 2, MART-2, Skinny hedgehog protein 1.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family. HHAT subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Co-localizes with SHH in the ER and Golgi membrane.
Protein: IL12A_CANLF
Sequence: MCPPRGLLLVTILVLLSHLDHLTWARSLPTASPSPGIFQCLNHSQNLLRAVSNTLQKARQTLDYIPCTSEEIDHEDITKDKTSTVEACLPLELTMNESCLASREISLITNGSCLASGKASFMTVLCLSSIYEDLKMYQMEFKAMNAKLLMDPKRQIFLDQNMLTAIDELLQALNFNSVTVPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRMMSYLNSS
What is the function of this protein?
Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine.  IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity.  Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits.  Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2.  In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity).  As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity).  Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers.  Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
What are the official names of this protein?
Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS4_LACJO
Sequence: MSRYTGPSWKRSRRLGISLSGTGKEISRRNYAPGDHGPNNRAKVSEYGQQLKEKQKLRWMFGLNERQFQNLFIRAGKIREGKHGVNFMALLERRLDNIVYRLGLASTREQARQLVNHGHILVDGKRVDIPSYEVKVGQEISLRDKSKNLQQVKDALDAVVSRPPFVSFDDSKMTGTLVRLPERDEMEPEVDEALIVEWYNKKL
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: GRPE_MALP2
Sequence: MENKNQKHNNEFHEKNQQSQKDNNNVKKENLHEDQSDLNDANFDDGGKKNKLKNDIKKLNHLVDSLKNENNNKQAKIESLERQINLLNENFKSEVIKKASEAQTKLDEKIKEFQAKYETELKHAKKYALKSSAIELIDIVSNFELAVNSKVTNPEIANYLKGFQMFANMFKNYFQQNGITEIPVNLNDDFNAEVMQAFETQKAPNTQPNKVIKIIKKGYKLHDIVLVPATVIVSE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_SALCH
Sequence: MIEFVYPHTHLVAGVDEVGRGPLVGAVVTAAVILDPARPIVGLNDSKKLSEKRRLSLYDEIKEKALSWSLGRAEAHEIDELNILHATMLAMQRAVAGLHIAPEYVLIDGNRCPALPVPSMAVVKGDSRVAEISAASILAKVTRDAEMAALDIVFPQYGFAQHKGYPTAFHLEKLAQYGATAHHRRSFAPVKRALGLVS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UDB19_MACFA
Sequence: MSMKWTSALLLIQLSCYLSFGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLAYSTSILPDPNNPSPLKFEICPTSLTETEFQDSVTQLVKRWSDIRKDTFWPHFLHVQEMMWTYGDMIRKFCKDVVSNKKLMKKLQESRFDVVLADAISPCGELLAELLKIPFVYSLRFSPGYALEKHGGGFLFPPSYVPVTMSELRDQMTFMERVQNMIYMVYFDFWFQVWDVKNWDQFYSKVLGRPTTLFEIMAKAEIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGDNGVVVFSLGSMVSNMSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTQLYKWLPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVRLDFDTMSSTDLLNALKTVINDPIYKENAMKLSSIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLACVATVIFIITKCLFCVWKFVRTRKKGKRD
What is the function of this protein?
Contributes to the formation of androgen glucuronide in extrahepatic steroid target tissues such as the prostate.
What are the official names of this protein?
UDP-glucuronosyltransferase 2B19, UDPGT 2B19.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: Y049_YERPE
Sequence: MDEWYGQVAPREKLLKYGAAVLTDAELLAIFLRTGIPGMHVMKMAEYLIETFGSLHGLISADYQTLCAHKGIGASKYSQIQAIGELACRCFSSHLMRESVLLNPGITQKFLQNILSHREREIFLVVFLDNQHRVIRHEEMFTGTISSVEVHPREIVREALKVNAAALILAHNHPSGKAEPSQADRLITTQVIKACSLLDIRVLDHLVVGRGECVSFAERGWL
What are the official names of this protein?
UPF0758 protein YPO0049/y0092/YP_0050.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family. YicR subfamily.
Protein: ERA_PSELT
Sequence: MNSGFVTLVGRPNAGKSSLINSFIGRKVLIVSEKPQTTRNKIRCIYTDSYHQIIFTDTPGIHKPVHRLGEFMVKVAIQAMKGVDLVLFVVDATKGFGEPEKRICDLVKLSKTETFLVINKIDLAKNYEFLAKTIVSECDCFSKVFFTSVVKNEGIEELLQAIKNCMPEGPMYFPENMLIDRPISFQIAEIIREKVLLFTREEIPHCVAVIVDTMEKRQNNLLYVAATIYVERNSQKGIIIGKNGNMLKQIGTLSRIEIESIVGSKVYLDLHVKVKKNWRDKDFIILNEIGMKDEIE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: TRAD_PENCR
Sequence: MKVLIIFAHPEPQSLNGALHRVAVEELEEQGHHVQVSDLYKMKWKSEVDREDFPNFPKDQRLDLWTASAEAYAENSLTQDVLDEQAKLRWADFVIFHFPLWWFTMPAILKGWVDRVYTYGFGHGLGEHSDKRWGDRYGEGTLTGKRAMLIVTLGGWKEHYSARGISGPIEDVLFPINHGILFYPGFEVLPPFVAFRVHKTSFDEMASTLRKRMREIEFTKPIPYRNQNDGEYSIPTLTLHESHGGDLASGFGLHTRTEVETTDVKEA
What is the function of this protein?
Ribosyldihydronicotinamide dehydrogenase-like protein; part of the tra gene cluster that produces terrestric acid (PubMed:30811183).  The clavatol biosynthesis cluster cla and the terrestric acid cluster tra are both involved in the production of peniphenones and penilactones (PubMed:30811183).  The non-reducing PKS claF is responsible for the formation of clavatol from successive condensations of 3 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit, and 2 methylation steps (PubMed:30811183).  The esterase claE probably collaborates with claF by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (By similarity).  The clavatol oxidase claD then converts clavatol to hydroxyclavatol (PubMed:30811183).  Spontaneous dehydration of hydroxyclavatol leads to the accumulation of the highly active ortho-quinone methide (PubMed:30811183, PubMed:31860310).  On the other hand, the PKS-NRPS hybrid traA is involved in the formation of crustosic acid, with the help of traB and traD (PubMed:30811183).  The polyketide synthase module (PKS) of traA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 3 malonyl-CoA units (PubMed:30811183).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with L-malic acid (PubMed:30811183).  Because traA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase traG (By similarity).  Crustosic acid undergoes decarboxylation and isomerization to the terrestric acid, catalyzed by the 2-oxoglutarate-dependent dioxygenase traH (PubMed:30811183).  Both acids are further converted to the 2 gamma-butyrolactones (R)-5-methyltetronic acid and (S)-5-carboxylmethyltetronic acid, with involvement of the cytochrome P450 monooxygenase claJ (PubMed:30811183).  Spontaneous addition of the methide to these gamma-butyrolactones leads to peniphenone D and penilactone D, which undergo again stereospecific attacking by methide to give penilactones A and B (PubMed:30811183, PubMed:31860310).
What are the official names of this protein?
Ribosyldihydronicotinamide dehydrogenase-like protein traD, Terrestric acid biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)H dehydrogenase (quinone) family.