PharMolix/UniProtQA huggingface dataset:
Protein: ATPA_PHAVU
Sequence: MVTIRADEISKIIRERIEQYNTEVKIVNTGTVLQVGDGIARIYGLDEVMAGELVEFEEGTIGIALNLESKNVGVVLMGDGLMIQEGSSVKATGRIAQIPVSEAYLSRVINALAKPIDGRGEILASESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAVGQKASSVAQVVTTLQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSQLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFASDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIVTIYTGTNGYLDSLEIGQVRKFLVELRAYLKTNKPQFKEIISSTNTLTGEAEALLKDAIKEQMELFLFQEQVEKN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: BIOB_CHLAB
Sequence: METHSELWSLEAIKEVYNTPIFELIHRANAILRSNFPHSELQTCYLVSIKTGGCTEDCAYCAQSSRYQTHVKPEPMMKITEVLDRAKQAIRAGATRVCLGAAWREVKDNHQFDRTLEMIKGITDMGAEVCCTLGMLTPSQAEKLFEAGLYAYNHNLDSSEGFYKTIITTRKYEDRLRTLDIVEKSGLHVCCGGIIGMGETVEDRVELLHNLARRERMPESVPVNVLWPIKGTPLYDQASISFWEILRTIATARIVFPQSMVRLAAGRAFLSVEQQTLCFIAGANSIFYGEKLLTVDNNDMDADTAMLNLLGMRHRPSFSMERGQPCQSVTC
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: FTMF_ASPFU
Sequence: MTVDSKPQLQRLAADADVDRMCRLLEEDGAFILKGLLPFDVVESFNRELDVQMAIPPPKGERLLADKYPPHFKYVPNVATTCPTFRNTVLINPVIHAICEAYFQRTGDYWLSAAFLREIESGMPAQPFHRDDATHPLMHYQPLEAPPVSLSVIFPLTEFTEENGATEVILGSHRWTEVGTPERDQAVLATMDPGDVLIVRQRVVHAGGGNRTTAGKPRRVVLAYFNSVQLTPFETYRTMPREMVESMTVLGQRMLGWRTMKPSDPNIVGINLIDDKRLENVLQLKAADSPA
What is the function of this protein?
Verruculogen synthase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:19763315, PubMed:23649274, PubMed:31117657).  The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA (PubMed:16755625).  Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (PubMed:16000710, PubMed:21105662, PubMed:23090579).  The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (PubMed:19226505).  The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable).  FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (PubMed:18683158).  Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (PubMed:19763315, PubMed:31117657).  In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
What are the official names of this protein?
Verruculogen synthase, Fumitremorgin biosynthesis protein F.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.
Protein: UPP_LEGPH
Sequence: MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETPLATMQSPVLKGKKLVFVSILRAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKLPEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFLCLLASPEGISNFHGEHPDVPIFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: GATA_PARMW
Sequence: MTISAWRQRLQAGGVSSRELVDEHLQRLEQSEPSLNAFVEVTAERARADADRVDQARAAGEDLGPLAGLPLAIKDNLCTRGVRTTCSSRMLEQFVPPYESTVTDRLWGAGAVLVGKTNLDEFAMGGSTETSAFGATKNPWNIEHVPGGSSGGSAAAVASGSCLASLGSDTGGSIRQPASFCGVVGLKPTYGRVSRWGLVAFASSLDQVGPFAGCVADAAELLQVIAGHDQRDSTCLTADVPNYSAGLAASIKGLRVGVIRECFEAEGLDAEVKASVQASAAQLEALGAELVDVSCPRFNDGIATYYVIAPSEASANLARYDGVKYGFRAEEAESLASMTARSRAEGFGAEVQRRILIGTYALSAGYVDAYYRKAQQVRTLIRRDFDAAFQQVDVLLTPTAPSPAFKAGAHADDPLAMYLADLLTIPVNLAGLPAISVPCGFSAAGLPIGMQLIGNVLDEARLLQVAHQYEQAADVFAQRPEASLVP
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: AVT3_YEAST
Sequence: MNGKEVSSGSGRTQSNNNKKNNNGGSTGISHASGSPLTDGNGGNSNGNSRSRSRSRKSSGTTGGLLKKPPLLVNNEAVHASVPDASHTSCNNGTLEVSINNPEPHVVDAVARHLIRNPSNSLQLQGGDITRDLYKWTNDHPSSPSQYQYPSQPALSTSIPSQAPSFSNRKRSMSFSAASIASSSHLNNNSEANGNPLAAIGLAPAPMTHEEIRAPGGFRRSFIIQKRRKHNVDAPIPNFFTRNFIEFLTLYGHFAGEDLSEEEEEEEETEEEPEEEALETESTQLVSREHGRHPHKSSTVKAVLLLLKSFVGTGVLFLPKAFHNGGWGFSALCLLSCALISYGCFVSLITTKDKVGVDGYGDMGRILYGPKMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYIFAQVLIFVPLSLTRNIAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNKADWSLFIGTAIFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFISCGLLCYAAFGSDVKTVVLLNFPQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPKVKWLKNYFRCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSGTSRARLLLDLIVIVFGVAVMAYTSWQTIKMWSQ
What is the function of this protein?
Involved in amino acid efflux from the vacuole to the cytoplasm.  Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine.
What are the official names of this protein?
Vacuolar amino acid transporter 3.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family.
Protein: TRMA_AERS4
Sequence: MTQIQQAGADSQALRTPADYQAQLDEKRERLTQLFAGFNPPALEVHASPAEHYRMRAEFRIWHEGDDLFHCMYAQATKEIIRVDHFPTASLLINQLMPVLLAGLRPHFVLRRKLFQIDYLSTQSGQIIVSLLYHRKLEAEWQQAAETLQADLQAQGFDLRLIGRAHKQKICLGDDFVIEQLNVAGRQLTYKQVENSFTQPNAAINEQMLGWALDVTRGSEGDLLELYCGNGNFSIALAQNFRKVLATEIAKPSVDSAQFNIAANGVDNLIILRMSAEEFTMAMRGEREFNRLKGVDLKSYQCNTIFVDPPRAGLDDATVKLVQEYDNILYISCNPETLQANMAVLGETHEVARFALFDQFPWTHHMEAGVYLKRKAG
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: RS21_BRUO2
Sequence: MQVLVRDNNVDQALRALKKKMQREGIFREMKMRGHYEKPSEKRAREKAEAVRRARKLARKRAQREGLIGGRTGAR
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: NAPA_HAEDU
Sequence: MELSRRDFMKANAAVAAAAAAGIVLPVKNVQADDSGIKWDKAPCRFCGTGCSVLVGTKDGRVVATQGDPDAEVNRGLNCIKGYFLSKIMYGADRVQTPLLRMKDGKFHKEGDFTPVSWDQAFSIMAEKVKATLKAKGGNAVGMFSSGQTTIFEGYAKVKLWKAGLRSNTIDPNARHCMASAAVAFLRTFGMDEPMGCYNDIEKTDGFVLWGSNMAEMHPILWSRISDRRLSDNNVKVVVMSTFEHRSFELADTPIIFKPHSDLAILNYIANYIIQNDKVNWDFVNKHTKFKRGETDIGYGLRPEHPLQKAAKNVKNAGKMHDSSFEEFKKIVEPYTLEKAHEISGVPKHQLEALAKMYADPAQKLVSFWTMGFNQHTRGVWVNHMIYNVHLLTGKISTPGCGPFSLTGQPSACGTAREVGTFVHRLPADMVVMNPKHVEICEKAWKLPKGTIPTVPGYAAVMQSRMLKDGKLNFLWQMCTNNMQGGPNINEEIFPGWRNPENFIVVSDPYPSVSAVAADLILPTCMWVEKEGAYGNAERRTQFWYQQVKGPAQSKSDLWQIVEFAKYFKAEEVWNEELMAQMPEYRGKTLYEILYLNGEVDKYQVPTNIPGYLNDEADDFGFYIQKGLFEEYAQFGRGHGHDLADFETYHQARGLRWPVVDGKETLWRYREGFDPYVKAGEDFRFYGYPDGKAIILGVPYESPAESPDEEYDLWLSTGRVLEHWHTGTMTRRVPELHRSFPNNLVWMHPSDAKKRGLRHGDKVKVITRRGEMISHLDTRGRNKCPEGLIFTTFFDAGQLANKLTLDATDPISGETDFKKCAAKVVKA
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: URM1_USTMA
Sequence: MSQDTVEIRVEFGGGTELLLAPPHEKKHTLTIPRTDTAGNETNVSFLIGHIRKNLITEREELFVDGDSVRPGILVLINNGDWELEGEGDYVLQDGDEVVFISTLHGG
What is the function of this protein?
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4.  The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U.  Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation.  Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1.  The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
What are the official names of this protein?
Ubiquitin-related modifier 1.
What is the protein family that this protein belongs to?
Belongs to the URM1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_CLAMS
Sequence: MSGHGAPEIDPTALDGTGLAVTVVAGRWHDEISAGLLAGAQRVLDAAGVTTTVIRVPGSFELPVVARAALDAGADAVVALGVIIRGGTPHFEYVSDAATSGLTQASLLTGKPVGFGLLTLDDEQQGLDRAGLPDSKEDKGAEAAEAAVTTALLLKAIRGA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: SHL2A_MOUSE
Sequence: MSGACSSYVSAEQEVVRGFSCPLPGGEAAAVFCCGFRDHKYCCDDPHSFFPYEHNYMWWLSIGALVGLSTAAVVLLAFLITACVLCYLFISSKPQTKLDPGLSLQTTGSKEMSPDHHGLNTAIPMEVPGVSSPRQSSSSNTHLESNKKQTVSPTCLPQNQFMATVTASNIPGSPDEISVPTPGPHGPVP
What are the official names of this protein?
Protein shisa-like-2A.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PDXA_BRADU
Sequence: MANHAAKPLALTLGEPAGIGPDITIAGWLRRRELNLPAFYLLGDEALIARRAKTLDKTLGKALGAEIRIASVSAHEAAAAFTEALPVVATGERATAEPGQPDASSAPAALASIRQAVADVRAGRAGAVVTNPIAKSVLYRAGFRHPGHTEFLAELAAKDGRVPQPVMMLWSPRLAVVPVTIHVSLRDALSQLTSELIVSTVRIVATELKSRFGIARPRIAVSGLNPHAGEDGSLGHEEQTIIAPALKTLRNDGIDARGPLPADTMFHEAARSSYDCAVCMYHDQALIPIKTVAFDDAVNVTLGLPFIRTSPDHGTAFDIAGTGKANPASLIAALELASRMAAAKT
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLA3_CANAX
Sequence: MSTEASVSYAALILADAEQEITSEKLLAITKAAGANVDQVWADVFAKAVEGKNLKELLFSFAAAAPASGAAAGSASGAAAGGEAAAEEAAEEEAAEESDDDMGFGLFD
What is the function of this protein?
Plays an important role in the elongation step of protein synthesis.
What are the official names of this protein?
60S acidic ribosomal protein P1-B, CaRP1B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein P1/P2 family.
Protein: TET55_UNKP
Sequence: MPHTKKILVIGASIAGPALCYWLNHYGFQPTLVEKNQSTRKGGYAIDLRGIAVDVAKQMGIYDSVCAMRTSLQCVRYVDAAGNLLFEEHGEKGGFRQGDEVEIVRGDLVDILMKTITDIPCFYDHAIESLTQHDDHVTVQFKNGKTENYDLVIAADGLHSATRRMVFSKDDYHLRNLGCYISVFSIPNYLQLDHCETLLEAKQKLVSITSDKDSTKAFAGFMFRSSNSPNYIRDEASQKDFLRENFTNHGWESNKLLSLMNDANDFYFDAIMQVKMKDWTKGRIALVGDAGYTPSPLSGQGTSLALVGAYILAGELKTATDHVAAFARYNELLKPYVEANQAFGVWVSESFLADEPLSAEQAEERNNIVLGIMKKATHAIELPEY
What is the function of this protein?
An FAD-requiring monooxygenase active on tetracycline antibiotic and some of its derivatives, which leads to their inactivation (PubMed:26097034).  Expression in E. coli confers high resistance to oxytetracycline, slightly less resistance to tetracycline, moderate resistance to minocycline but no resistance to tigecycline.  Degrades tetracycline and oxytetracycline; the reaction requires NADPH (PubMed:26097034).  Degrades and confers resistance to chlortetracycline (PubMed:28481346).
What are the official names of this protein?
Flavin-dependent monooxygenase, Tetracycline destructase Tet(55), Tet(55).
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family.
Protein: PCP_BACCZ
Sequence: MKTVLLTGFDPFGGESINPAWEVAKSLHEKTIREYKIISKQVPTVFHKSIQVLKEYIDELNPEIIICIGQAGGRPDITIERVAINIDDARIADNEGNQPVDVPVVEEGSAAYWSTLPMKAIVKRLQAEGIPASVSQTAGTFVCNHLFYGLMHELEKQDQKIKGGFVHIPFLPEQASKYPGQSSMSLSTIRKGIELAVEVTTTVEVDIVEVGGTTH
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_OCEIH
Sequence: MLVSYNWLKNYVNLDAVTPEELAAKITKSGIEVEGVEYIAEKNENIVVGYVETCEKHPDADKLNVTQVSVGEETLQIVCGAPNIAKGQKVAVAKPGAVLPGNMKIKKVKLRGVESNGMICSLQELGLEEKYIPTDIAEGIFVFPEDEDIEVGSKVDEWLNLTDAVLDLDVLANRPDALSMLGVAYEVAAVLDQPIELPTKNIDYIDEKVSDQIEINIESKDLNPYYAAFMVKDVVIKPSPLWMRNYLMASGIRPINNIVDITNYVLLEYGQPLHAFDFDRFASNQIVIRRGVEGEVIQTLDEQERKLTEDNLVITNGSEPVALAGVMGGANSEVTDKTVNVLLEAAYFEATAVRHTVRQTGLRSESSTRFEKGIDPNRIVEAGLRACQLMQRYAGGKVLQGFAEENHLDTKSTKEVKVPLTQVNQRLGMELTEKDVQSVLNRLKFDFDQDGHTFIVHVPTRRRDITIFEDMLEEIIRIHGYDHLPYTIPQGWVKSGGLTDKQLLQRKIREFMMSSGAMETLTYSLTNEQNVKRLVTPNIDLENSYPISLAMPMSEDHKYLRLSIVPELLRILQHNIARKQTDLNYFEIGKVFISEEQELTHQPTEKLHLAGAFTGLWHNHPWQQDKKQVDFFVVKGIIEGLFNYLQLNISFKQVKMKDMHPGRCAELNIDGENIGFMGQLHPKTANVFDLPETYVFEIDLESVFEKYINVPSFTDIPRYPSVSRDIAFILDTEVFSGEVQQYIQEIGAPLVKEVSIFDVYQGEHLEDGKKSVAYRLMYQDPAKTLQDDEVESSYQQIVEAVNKKFGSYVRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEUL_RABIT
Sequence: MIARCFSAVRGLHRVGGSRILFKMTLGREVMSPLQAVSSYTAAGRNVLRWDLSPEQIKTRTEELIAQTKQVYDSVGMLDIKDVTYENCLQALADVEVKYIVERTMLDFPQHVSTDREVRAASTEADKRLSRFDIEMSMREDIFQRIVHLQETCDLEKIKPEARRYLEKSVKMGRRNGLHLPEEVQNEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKMDDDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTVILQQLLPLRAQVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILSLKKKECEEKGFEYDGKINAWDLHYYMTQTEELKYSIDQEFIKEYFPIEVVTEGLLNIYQELLGLSFEQVADAHVWNPSVTLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMLSVAALVVNFSQPVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDIDSLRRLSKHYKDGNPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNSSLDAASEYARYCTDILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILRPGGSLDGMDMLQNFLQREPNQKAFLMSRGLQAP
What is the function of this protein?
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.  Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.
What are the official names of this protein?
Neurolysin, mitochondrial, Microsomal endopeptidase, MEP, Mitochondrial oligopeptidase M, Neurotensin endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Cytoplasm, cytosol.
Protein: METK_PINBN
Sequence: METFLFTSESVNEGHPDKLCDQISDAVLDACLAQDPDSKVACETCTKTNMVMVFGEITTKADVDYEQIVRKTCREIGFISDDVGLDADHCKVLVNIEQQSPDIAQGVHGHFTKRPEEIGAGDQGHMFGYATDETLELMPKCHVLATKLGAKLTEVRKNGTCPWLRPHGKTQVTVEYRNDNGAMVPERVHTVLISTQHDETVPNDEIAPDLKEHVIKPVIPEKYLDENTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSIVANGLARRCIVQVSYAIGVPEPLSLFVDTYGTGSIPDKEILEIIKEHFDFRPGMISINLDLKRGGNGRSQKTAAYGHFGRDDPDFTWETVKPLKWEKAQA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase, MAT.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_ECO24
Sequence: MAKEDNIEMQGTVLETLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVELTPYDLSKGRIVFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_GEOUR
Sequence: MKIYYDKDCNLSLLKGKKVAIIGYGSQGHAHANNLKDSGIDVVVGLKADSASVKKATEAGLTVLTTSEAVKIADIIMILLPDEIQGDVYREEIAPYVKQGAYLAFGHGFNIHFGQIVPRHDINVIMVAPKGPGHLVRHEYTKGGGVPSLIAIHHDPSGNSRDVALAYASANGGGKAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYEGGIANMRYSVSNTAEYGDLTRGPRVITGETKKEMKKILTEIQEGEFAREWMLENKVNNPRFNALRRKGTEHQIEEVGARLRSMMAWIGKSKIVDKTKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: MPSIN_RHIMP
Sequence: MKAIFVSALLVVALVASTSAHHQELCTKGDDALVTELECIRLRISPETNAAFDNAVQQLNCLNRACAYRKMCATNNLEQAMSVYFTNEQIKEIHDAATACDPEAHHEHDH
What is the function of this protein?
Has bacteriostatic activity against the Gram-positive bacterium M. luteus, but not against Gram-negative bacterium E. coli SBS363.  Has fungistatic activity against C. neoformans, but not C. albicans.  Binds and sequesters copper and iron ions.  Copper-chelating is crucial for antimicrobial activity against M. luteus.
What are the official names of this protein?
Antimicrobial peptide microplusin, Microplusin.
Protein: Y104_RICPR
Sequence: MALFPRSILIALVLSFVLNLGLVTKIHAKDTLDSIIDILSGLTCETQGVGDLMRTEFSHTCIVAPFFTFAVMNLVSPVLYMNTFLKLKINDSDLFNDSDFGNFPGGQCTRANRIDPKNPELRFALCNNAKLIVSRAKSVAESALAIAKAVLTWSDPWDDIKQAWENKKKEYHIPYRGKPGDDGFAFDVGFPVIYWKVIQDRDRICVSTKGFTGDVPVGCKYMKEPFPKSIYNSFIDVEDKNFIKDPTNDTPSDPLALVSCSAAGEGCYQKAYNASKTAVVMTSPLIECIKQMIARLLISKDVCSFDNVDQVVNLSSRQDSALFQFQVGMYKIVTAFLTLYVMFFGFKLLLAGKVPPKSEYINFILKIIFVTYFSIGININPANGSQYDRLDGMIQWAFPFLLNGINGLASWVMNAAPSGLCKFNNIHYDGSVSYIALWDALDCRVAHYLGLDILSTLLVENTYRSHDFLNFDFFSFSAPPYIYLLIPAIISGNMMLVSLALSYPLLVISVAAFMVNATIMCMISIVILGILAPLFVPMFLFAYTRNYFDSWVKLMISFLLQPMVVVTFMITMFAVYDYGFYGKCQYKSKLIHNSIEDKIQGGLKSKRDVLIFYINNDWDDTSQYPDKDSVESCKNSLGYMLNNPINMAFNFAKDNISEIVNSKPGETTTDEFLSKFQFLSGVVLGPGMFFMSPKVLFEKIKNILLALVTACFTLYLMYNFSSQLAEFAADMTEGVALNNVAIKPQAIFKAAMAALSTAGTATKGIDQMASRGGGARDLGGAKGFVSDNTASSGSAVGDNIAVSRGASTPTVTTTTDSSSITNSITKTVSSDVRSDIVTPHSPTTAFSQHSSISSTIPTSVHNIKPTSIKEIVSNNRESKKEINNTMRSQEKIKSASKALGLIDYSFNLKEHDNPIGVKQIRENAEIRDKRVEVEKAWNELVASGRGRIRDQQSEATSERRTNAEKKWKELVDSGVVTEIRERDNSVTNQFDKLADELDKSKKSKVEENKNITKDIKVDNTNTLPQEKVDNTNRRSGLIDYSFNLKEHDNPIGVKQIRENAEIRDKRVKVEKAWNELVASGGGRVQEQAGVKITERRANAEKVWDELVKSGVVTEKRDNSSNENS
What are the official names of this protein?
Uncharacterized protein RP104.
What is the protein family that this protein belongs to?
Belongs to the TrbL/VirB6 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RAB2A_MACFA
Sequence: MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between active GTP-bound and inactive GDP-bound states.  In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.  Required for protein transport from the endoplasmic reticulum to the Golgi complex.  Regulates the compacted morphology of the Golgi.
What are the official names of this protein?
Ras-related protein Rab-2A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity).