PharMolix/UniProtQA huggingface dataset:
Protein: SUCC_HAEIE
Sequence: MNLHEYQAKQLFEHYGLPVKNGAVCQSVDEVDLVLAQLSGDKWAAKCQVHAGGRGKAGGVKLVQDVEEARSFAEKWLGQRLVTFQTDKLGQPVNQIYFEETCDIDKEFYLSAVVDRASQKVVFIASPAGGMDIEEVAQNTPHLLHKVEIDPLFGGLPYQGRELAFKLGLSGTQNKQFTDIFMGLSRLFLEKDLSLLEVNPLVLTQQGNLVCLDAKIAVDDNALFRHKDLSALQDLTQNDAREAEAEKFQLNYVALEGDIGCMVNGAGLAMGTMDIVKLYGGKPANFLDVGGGATKERVAEAFKIILTDPSVKVILVNIFGGIVRCDLIAEGVIAAVNEVGVRVPVVVRLEGTNAEIGRQILAESDVNILTAHSLQQAAELAVNAAKGEH
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: Y1150_LIMF3
Sequence: MKMIISPAKQMVSDDEPLVRPTPIRFPAQVTELMADLKSRTPAELQELWRCSDKLARENVARVQAFDLKRVGTPAVFAYAGIQYQSLGAGVLTDRGLQNLGQRLYILSGLYGLLGAFDGILPYRLEMGAKGEIAGAKNLYQYWGARLYQALFASGDLVVNLASKEYSKAITPYLTPADRWVTVLFKQEKNGRLVQQATAAKKARGSLVRYLALENEPTLATIKAFTVGGYRYRADLSTEAEYVFVKD
What are the official names of this protein?
UPF0246 protein LAF_1150.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: TILS_SALTY
Sequence: MTTLTLNTSLLSSRRILAAFSGGLDSTVLLHQLVLWRERHPDVTLRAIHIHHGLSPHADSWVRHCETVCERWQVPLVVERVTLADNGLGIEAHAREARYRAFAQTLLPGEVLATAQHLDDQCETFLLALKRGSGPAGLSAMGERSPFAGTLLLRPLLRETRKTLEQWAVRHGLCWIEDESNQDDAYDRNFLRLRALPLLQQRWPHFPAAVARSATLCAEQERLLDELLASDLTDCITAEGTLRLSPLMSMSDVRRAAILRRWLAMRNAPMPSRDALERIWQEVALARDDASPCLRFGDHEIRRYQSQLWWIKSVAGQHETTVAWPVWQTPLALPAGLGTVQLVPGGELRRPREEESVSIRFKAPGVLHIVGRNGGRKLKKIWQEQGIPPWRRDTTPLLFYGETLIAAAGVFVTREGAAEDKEGVSLVWHA
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_GEOSL
Sequence: MKKLFGTDGVRGVANVYPMTTEMAMQIGRAAAYLFKDGNRRHRIVIGKDTRLSGYMLENALVAGICSMGVDVLVVGPLPTPGIANITSSMRADAGVVISASHNPFQDNGIKFFSRDGFKLPDEMELKIEDLIFSGKIDSLRPVATEVGKAYRIDDAVGRYVVFLKNSFPKDLDLAGMKIVLDCANGAAYKVAPAVLEELGAEVIPYGVKPNGTNINAGCGSLYPQVISEAVKEHRADLGIALDGDADRVIFVDEFGNEVDGDHIMAICATQMLKQKKLRKNTLVATVMSNMGLDIAVKRAGGKVVKTAVGDRYVVEEMIKGGYNLGGEQSGHMIFLDPNTTGDGVLSALQVLATMRRADKSLSELAEVMIPLPQVLVNVRVKEKKDITTIPEVALLIGDIEKKLGDEGRILIRYSGTEPLLRIMLEGQDKYQITGWAKEIADLVEKKIGGK
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: SYR_SALTS
Sequence: MNIQALLSEKVSQAMIAAGAPADCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLSGIASKVEIAGPGFINIFLEPAFLAEQVQQALASDRLGVSQPTRQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHHVIRANHVGDWGTQFGMLIAWLEKQQQENAGDMALADLEGFYRDAKKHYDEDEAFAERARNYVVKLQSGDTYFREMWRKLVDITMTQNQITYDRLNVTLTRDDVMGESLYNPMLPGIVADLKAKGLAVESEGATVVFLDEFKNKEGDPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWTIVRKAGYVPDSVPLEHHMFGMMLGKDGKPFKTRAGGTVKLADLLDEALERARRLVAEKNPDMPADELEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKANIDEQALASAPVIISEDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDVAGLFSGFYEHCPILSAENDAVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_HYPNA
Sequence: MQKKRIWTNARLATMAAGLPGLGIVEDGLIAAEGDRITFAGLASDFPYTEGPSTQGYEVTDCGGRWILPGLIDCHTHLVWAGSRADEFERRLAGASYEEIARSGGGIRSTVSAVRAASEAELVAESLPRLNALIGEGVTTIEIKSGYGLNIEDELKQLRAARALGEVRPIDVETTLLAAHTLPPEYEGRADAYIDLVCNEIIPAAAQAGLASAVDAFCETIGFTPEQTGRVLSAARHHGLAVKLHADQLSNLQGGALAARHNALSADHLEYLDEAGIAAMAQAGMVAVMLPGAYYVLRETHPPPLEGLRRAGVSLAISTDCNPGTSPLTSILLAMNMGATLFRMTVEECLLGTTRHAARALGLEKATGTLEAGKLCNLSIWDIDRPAELVNAMGLNPLHTRVWRGQ
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA_PROM0
Sequence: MKRVALLVQYDGSHYSGWQKQKNATTVQEILDRALLKITNHTVQTFAAGRTDAGVHASGQVVHCDVDCVVPGNSYSDVLNSLLPSSIRILESIEVKDSWHACYSALYRHYRYVINNSKFPNLFIDNWSWHRYQKVLDEVLMLNASRQMIGEHDFFAFQKTGSNRTNSITKIKNIDIKRVEDLIFVDIKATGFLYGMVRLIIGQLVLVGENKISPEIFTDRWVNKKKNDVKESAPAKGLCFVNAVYEENVFKKINNNDFFPVFIIKGFS
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: NACA_NEUCR
Sequence: MADPRVEELPEEEVKKTQVEDLDNSSDDESDIEAGDSSLPAGSQAVIHSRNEKKARKAIEKLHLQRVPGITRVTLRRPKNILFVINNPEVYKSPNSNTYIVFGEAKIEDLNASAQAAAAQQLASQSAEHDHAGHTHEHEEAGKAKEEEEEDEGEEVDAEGIEDKDIELVMTQANVSRKKAIKALKENDNDIVNSIMALSI
What is the function of this protein?
Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting.  The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum.  Npc-1/egd2 may also be involved in transcription regulation (By similarity).
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC, Nascent polypeptide complex protein 1.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus.
Protein: 6OMT_PAPSO
Sequence: METVSKIDQQNQAKIWKQIYGFAESLVLKCAVQLEIAETLHNNVKPMSLSELASKLPVAQPVNEDRLFRIMRYLVHMELFKIDATTQKYSLAPPAKYLLRGWEKSMVDSILCINDKDFLAPWHHLGDGLTGNCDAFEKALGKSIWVYMSVNPEKNQLFNAAMACDTRLVTSALANECKSIFSDGISTLVDVGGGTGTAVKAISKAFPDIKCTIYDLPHVIADSPEIPNITKISGDMFKSIPSADAIFMKCILHDWNDDECIQILKRCKEALPKGGKVIIVDVVIDMDSTHPYAKIRLTLDLDMMLNTGGKERTKEEWKTLFDAAGFASHKVTQISAVQSVIEAYPY
What is the function of this protein?
Involved in the biosynthesis of (S)-coclaurine, the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or papaverine.  Catalyzes the transfer of a methyl group to norcoclaurine to form coclaurine.  Methylates (R,S)-norcoclaurine, (R)-norprotosinomenine, (S)-norprotosinomenine and (R,S)-isoorientaline.
What are the official names of this protein?
(RS)-norcoclaurine 6-O-methyltransferase, Ps6OMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: PAN1_YARLI
Sequence: MYGYQGTGGQQPLGAQPTGFGFGNTPVQQQQQPMQPMQQSQPTGYQAPGGFQNYQPTGFAQQQQQQQPQQTGFQSMQPPMQQTGFQSQPNVSMYQGGGGQGYQSAPMLHQQTMQTGYQPQQQQPGFTGFQPQQQQQQQQTGFTGFQQQPQQQQPGFTGFQSQPTGYNANASAPAATPAAPLQQQKTGNARDPFAPTLPARPPLTSQPTGGGNKSVVDGVYIPNVRLSFLTADDQRNFENLFRQALPKGEQALSGDKARDILFRSGLPPITLSAIWNLADTTRSGALLFPEFAVAMYLCGQAVKGQTVPNNLSENIKNEVSSMVDIISFNIPDAGSRPSSSGQSVPQSQPQQQQQQSSASMLAGLNLGQPTGYQQQQATGYQPMQQQSTGYPMQAMQPQITGGMPLQQQRTGPMQPLQQQSTGYAPLQSQLTGGAPLQSQLTGGAPLQSQLTGGAPLQSQLTGGAPLQQQSTGYAPLQQQSTGYAPLQQQSTGYMPQQQTGMQPQSTGYGSMQPLTAMPTGKPGQWGFINTPSQGLPGIETMQQRLMPQATGAPVQQLPPMQLQQSATVNWAIAKEEKQIYDGIFMAWDKKRAGAIDGDTAIKIFTQSGLNRADLEAIWTLSDPSNKGRLDRDEFAVAMHLIYRHLNGYPIPSRLPPELVPPSSKNFSDSVNQVKSYLKAGGGRTGGSKLKSRSFTGDSTIKKDATVFKNDDSDFGYTSRNRRGGSSSTASSNGSSGNDISLSGKGSSISELKKLIREKQILLDAIDAEDSDMSRDSNLERRDQEAVADLKRRIQNVQRDIDVAPHSAISTDVGASADAKRNLMRKLDHLGDRLPQLASNVRRIEDKIANAKMELFRLKNPTSLVGTGPGGAITEADRIKARSKAKLQARMAALTGKGTTTGADASEEEDYEHRLLTHTSEVERSKAQNYEMIHDIEDSVKSLQRDLSSKLRETQEEVSEDRQRRRWEEAVGVEDDVRQFIYSLRSTRSSRPAPATASSSAPATGSPATAAPISATSTGASTPSAPAAGVDRKAQLKAEAERKMNERLAALGIKRKEKAQAHGFAPPDAKPAEASPAASPAVASPAVASPAATPAVSSPAPVSRGVPAPAAATPATDPATTPAVPVSAPADDSDSDDEEYEKLMAQKREQEERFKKQQEADKKKEEEKKQKKAAKEERMRKLREEMEANEAREKAWKESQSKEAEADEAEGDVGAAALAAFSNKATAPSTTPTAVAATPPVATSTPSPAAPTVPAADDNNPFHRLNNGGDAAAAAPAAGGEDNNPFLRPGTNQPIAAPSPASFSEAPKEAPKPVDPVKISNQRANQRAAKNDDDDWGMSSDEDDDQDYHRGNAAELASQLFRTMAPPIQRQPTGGAPITATPTGSAPAAPPAAPPVAPAAVEVAVAASEATPGPESAPPAPPMPEINIPPATEAPSAPAATEAPPAPPSAPTTIETTHLPPPVDTHNDMSSSEFDFETPEGSPTQQTFAEAAPPVAAPPPPPPTAAAAAPTGIPPPPPSAPGFGAPEAPSGIPPPPPPAPGFGAPPPPPGPAPSFDAPGGAPPPPPPGPPPPMFGAPAPPSMTGPSAGDLPERPPAATGGITALLGEITGGKTLRRVDDKDKKISSNPSAGAVLN
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein PAN1.
What is the protein family that this protein belongs to?
Belongs to the PAN1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: DER_PECAS
Sequence: MIPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEVEGHEFIIIDTGGIDGTEDGVETRMAGQSLVAIEEADIVLFMVDARAGLMPADEGIAKHLRSREKMTVLVANKTDGLDPDMVTADFYSLGMGEVYAIAASHGRGVTSLLETVLLPFVQDEIEEPVELTEEEENAAYWAALEAEEQASEEEAEDDFNPEDLPIKLAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMVRDEREYILIDTAGVRKRGKVTETVEKFSVIKTLQAIEDANVVLLVIDAREGISDQDLSLLGFILNSGRSLVIVMNKWDGLSQEVRDQVKDTLDLRLGFIDFARIHFISALHGSGVGNLFESVTEAYSCATRRVSTAMLTRIMQMASDDHQPPLVRGRRVKLKYAHAGGYNPPIVVIHGNQVKDLPDSYKRYLMNYYRRSLEVMGTPIRIQFKEGENPFAEKRNKLTPTQLRKRKRLMSHLKKSK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: GT_LAMBD
Sequence: MFLKTESFEHNGVTVTLSELSALQRIEHLALMKRQAEQAESDSNRKFTVEDAIRTGAFLVAMSLWHNHPQKTQMPSMNEAVKQIEQEVLTTWPTEAISHAENVVYRLSGMYEFVVNNAPEQTEDAGPAEPVSAGKVFDGELSFALKLAREMGRPDWRAMLAGMSSTEYADWHRFYSTHYFHDVLLDMHFSGLTYTVLSLFFSDPDMHPLDFSLLNRREADEEPEDDVLMQKAAGLAGGVRFGPDGNEVIPASPDVADMTEDDVMLMTVSEGIAGGVRYG
What is the function of this protein?
Promotes tail assembly by creating a scaffold for the tail tube proteins.  Tail assembly proteins G and GT probably wrap the linear tape measure protein to create a tail assembly scaffold.  This allows the polymerization of the tail tube protein, during which G and GT are released, therefore they are absent in the mature virion.  The tail assembly protein GT is produced by a rare -1 ribosomal frameshift.  The ratio of translated G/GT is about 20, and this ratio is important for proper tail assembly.
What are the official names of this protein?
Tail assembly protein GT, Gene product 15, gp15, Gene product GT, gpGT, Minor tail protein GT.
What is the protein family that this protein belongs to?
Belongs to the lambda-like tail assembly protein family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: BTC_BOVIN
Sequence: MARAAPGSGASPLPLLPALALGLVILHCVVADGNSTRSPEDDGLLCGDHAENCPATTTQPKRRGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYAGARCERVDLFYLRGDRGQILVICLIAVMVIFIILVVSICTCCHPLRKRRKRRKKEEEMETLGKDITPINDDIQETSIA
What is the function of this protein?
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members.  Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells (By similarity).
What are the official names of this protein?
Probetacellulin.
What are the subcellular locations of this protein?
[Betacellulin]: Secreted, extracellular space. SUBCELLULAR LOCATION: [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
Protein: CRERF_DROME
Sequence: MTENQLYPMSSEFFDTGSNSSSNTLKYDLYSLGSTVVGAALPTLTINTGYGSSSSNNNNTNNNNNNSSSHSSSSNCSTSTTNTCNVMLSTTAITIPRSSNHNQIHHHPYQQSDLQTPRHHPSPLHTLPSMTHQQNQLQQQQQQQHHNQQQQLQQSHLALGELSDFGLDALDAASLSPTLLQDVSLSAVSPLSTTLYNGNTSGAGSSNGIGSGSGGYFTPDMSHSLSLNVVSEQVLLQEATTPNELLYEMTPNSNAMWSDISSAIIHTKHEPFSLDDDYIFPNDKAEIQAADLSDLNGGDFLDVIGNIEDFLPQTAVTQSVNFLLSPQAQGQDALVAPPMELLQQQQQNHQQLQVGSLPQLQTLLTLSQQQQSNSSSTSPYEIYHSTPQKPQQQQLSASFSPGSQASQSPLTPPPPPHANRPQYQMVKSRNMQELIKKGFPMSSPPERSILSQSAALSPGGSSGFGSSASGNSTTTSNQTSGSAVRKSFGYQSAVENSQLSRLSSSAPTHLGLEHIWMRREPRQHLLSTGSLAEAESFSSLSTGSVLSPDGIDFSQDDEDDNSSENSDNYDDCSSDNGLSEDEDETRTSTPNHLSSSKGKERFFWQYNVQAKGPKGKRLVFQSKLEDPHVLNEVTDPVFSPTCSVRGIKVYKHSGKARKGDGNDLTPNARKLHNIGKELDKLSRTINDMTPVSELPFNVRPKSRKEKNKLASRACRLKKKAQHEANKIKLFGLEIEHSEFNVKAVEISYNPSIFVL
What is the function of this protein?
Transcriptional regulator that acts in the TORC1 signaling pathway to regulate energy homeostasis and promote survival during nutrient deprivation.  Interacts with REPTOR to form a transcriptional activator complex that functions downstream of TORC1 to up-regulate the expression of most target genes induced by TORC1 inhibition.  In the complex, acts as the transcriptional activator.  Under normal conditions TORC1 is active, inhibiting the formation of the REPTOR/REPTOR-BP complex by phosphorylating REPTOR and mediates its cytoplasmic retention by forming a docking site for 14-3-3 proteins.  Upon TORC1 inhibition resulting from nutrient stress, REPTOR is recruited into the nucleus where it interacts with REPTOR-BP and together they maintain organismal metabolism by activating the expression of target stress response genes including those involved in glycogenesis and triglyceride biosynthesis.  The complex also appears to negatively regulate some aspects of TORC1-dependent larval growth.
What are the official names of this protein?
Protein CREBRF homolog, Protein Repressed by Tor.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. CREBRF subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=Translocation from the cytoplasm to the nucleus is promoted by dephosphorylation and inhibited by phosphorylation. Binds to chromatin.
Protein: Y2049_STAEQ
Sequence: MAKVKEKVAVVTGASSGIGEAIAKKLSQQGASIVLVGRNEQRLNEIAQQLNTPAKVVSADVTVKSNIDDMLKAVIDHFGHIDIVVNSAGQSLSSKITDYNVEQWDTMIDVNIKGTLHVLQATLPYLLKQSSGHIINLASVSGFEPTKTNAVYGATKAAIHAITQSLEKELARTGVKVTSISPGMVDTPMTEGTDFGERKKLEAQNIADAVVYALTQPSHVNVNEVTIRPV
What are the official names of this protein?
Uncharacterized oxidoreductase SERP2049.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PLYW_DICD3
Sequence: MSIFTDLNTSRKWQIDQWLSAVNSHIEKIQQYGHSVVNPTPLLADGFEIKTQSPVVWQFPDGHDAPISNFASQQNWLRLLISMSVITETEKYRHLAFCQSEYFLNRFVDENSGLFYWGGHRFINLDTLASEGPESKSMVHELKHHLPYYEFLHQVNPEKTRHFIQGFWNAHVEDWSCLDLGRHGDYARQRDPDVFLHSRHDVVTPANWPELPLTKGLTFVNAGTDLIYAAFVYARHTGDAHAAAWGKHLYRQYVLARNPETGMPVYQFSSPLQRQPVPADDNQTQSWFGDRAQRQFGPEFGAIAREANVLFRDMRPLLIDNPLAMLDILRHQPDAEILTWVIAGLKNYYQYAYDVNSNSLRPMWNNGQDMTDYCFKRDGYYGKAGTVLKPFPLEGDYLLPLVRAWLLSDDDDLHTLIVTMLSRLEKQGIHQSASPFLLLAITELAHAKQSAQWAEYAWQMAEILFKRYFHHGLFVRSEHHRYVRLDDPFPAILLTLIAACRNKWSEVPAVLTQGGYIHGDYRINGESRVIYDTEFIYPEKLIH
What is the function of this protein?
Catalyzes the formation of unsaturated digalacturonates from polygalacturonate or short oligogalacturonates.
What are the official names of this protein?
Pectate disaccharide-lyase, Exopolygalacturonate lyase, ExoPL.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_PSESM
Sequence: MSKQILILPGDGIGPEIMTEAVKVLELANQKYQLGFELTHDVIGGAAIDKHGVPLADETLDRARAADAVLLGAVGGPKWDTIERDIRPERGLLKIRSQLGLFGNLRPAILYPQLADASSLKPEIVAGLDILIVRELTGGIYFGAPRGTRVLDNGERQAYDTLPYSESEIRRIAKVGFDMAMVRGKKLCSVDKANVLASSQLWREIVEQVAKDYPEVELSHLYVDNAAMQLVRAPKQFDVIVTDNLFGDILSDQASMLTGSIGMLPSASLDTANKGMYEPCHGSAPDIAGQGIANPLATILSVSMMLRYSFNLTAAADAIEQAVSLVLDQGIRTGDIWSEGKVKVGTKEMGDAVVAALRNL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSC_YERPY
Sequence: MARKRIAFIFTQGPHGSSAGREGLDALLATSALSEDIGVFFISDGVLQLLPQQQPEKILARNYIATFGVLPLYDVENCYLCERSLQQRGLSKMADWILDVTVLSPADLRRELGTYDVVLTF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusC, tRNA 2-thiouridine synthesizing protein C.
What is the protein family that this protein belongs to?
Belongs to the DsrF/TusC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPR3E_MOUSE
Sequence: MSPERPPRTDIPRNLSFIAALTERAYYRSQRPSLEEESEEEPGEGGTRPGARSRAHVPGRGRRARSAPAGGGGARTARSRSPDTRKRVRFADALGLELAVVRRFRPGEPPRVPRHVQVQLQRDALRHFAPCPPRARGLQEARVALEPALEPGFAARLQAQRICLERADAGPLGVAGSARVLDLAYEKRVSVRWSADGWRSLRESPASYAGPAPSPPRADRFAFRLPAPPVGGTLLFALRYRVTGREFWDNNGGRDYALLGPEHPAGAGAAEPQGWIHFI
What is the function of this protein?
Acts as a glycogen-targeting subunit for PP1.  PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.
What are the official names of this protein?
Protein phosphatase 1 regulatory subunit 3E.
Protein: PIMT_GLOVI
Sequence: MVDEQLRPRGVEAQAVLAAMAKVPRHRFVPPPYTRLAYEDRPLPIGHSQTISQPFIVAYMSEAARITPGAKVLEIGTGSGYQAAVLAEMGAEVYTVEIVPELAKRAERTLEELGYRSVRVRSGDGYQGWPQHAPFDAIVVTAAPERIPQPLIDQLAVNGRLIVPVGTQTEDQRMTVLTRTPGGIVEQKTFPVRFVPLTREKPQEH
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTLE_BORBR
Sequence: MPDPRPLTPDQTHGRGHAEAAVDWEASRLYRLAQSERRAWTVAWAALAVTALSLIAIATMLPLKTTIPYLIEVEKSSGAASVVTQFEPRDFTPDTLMNQYWLTRYVAARERYDWHTIQHDYDYVRLLSAPAVRHDYETSYEAPDAPDRKYGAGTTLAVKILSAIDHGKGVGTVRFVRTRRDADGQGAAESSIWVATVAFAYDRPRALTQAQRWLNPLGFAVTSYRVDAEAGQP
What are the official names of this protein?
Type IV secretion system protein PtlE homolog.
What is the protein family that this protein belongs to?
Belongs to the virB8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: F199X_HUMAN
Sequence: MSDEASAITSYEKFLTPEEPFPLLGPPRGVGTCPSEEPGCLDISDFGCQLSSCHRTDPLHRFHTNRWNLTSCGTSVASSEGSEELFSSVSVGDQDDCYSLLDDQDFTSFDLFPEGSVCSDVSSSISTYWDWSDSEFEWQLPGSDIASGSDVLSDVIPSIPSSPCLLPKKKNKHRNLDELPWSAMTNDEQVEYIEYLSRKVSTEMGLREQLDIIKIIDPSAQISPTDSEFIIELNCLTDEKLKQVRNYIKEHSPRQRPAREAWKRSNFSCASTSGVSGASASASSSSASMVSSASSSGSSVGNSASNSSANMSRAHSDSNLSASAAERIRDSKKRSKQRKLQQKAFRKRQLKEQRQARKERLSGLFLNEEVLSLKVTEEDHEADVDVLM
What are the official names of this protein?
Protein FAM199X.
What is the protein family that this protein belongs to?
Belongs to the FAM199 family.
Protein: DNAS1_HUMAN
Sequence: MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
What is the function of this protein?
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032).  Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity).  Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278).  Binds specifically to G-actin and blocks actin polymerization (By similarity).  Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity).  NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity).  Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
What are the official names of this protein?
Deoxyribonuclease-1, Deoxyribonuclease I, DNase I.
What is the protein family that this protein belongs to?
Belongs to the DNase I family.
What are the subcellular locations of this protein?
Secreted. Zymogen granule. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.
Protein: KISH_DROME
Sequence: MSALFNFHSLLSVILLLICTCAYLRSLFPSLIDRNKTGFMGTFWKLARIGERKSPWVGAACLIMAFTVLFWS
What is the function of this protein?
Involved in the early part of the secretory pathway.
What are the official names of this protein?
Protein kish.
What is the protein family that this protein belongs to?
Belongs to the KISH family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.