PharMolix/UniProtQA huggingface dataset:
Protein: ASNA_LEIMA
Sequence: MDPTLKELLHANLEWIFVGGKGGVGKTTTSCALATLFATTPISDAASPGGTRPRRVLLISTDPAHNLSDAFNQRFGPHPTPVKGLEESLAAMEVDPKNFTHGALMSSLTGAKSDGSASSLSAEAEADAAQHTASFARIGAVLKEAARTMPGIDEISVFAEILHYVRTLFYDLLIFDTAPTGHTLRLLALPQTLSSTFDKLMSLEGLAPMIEAASHLIGTNLGALGGACGDTAGSCEQATAAPSLSSAAPGEGSAAAASSQSRWCITADEVRSTALHWRQTMEEVQARFNDPNRTSFVCVCIAEFLSVYETERLVQELMKYNIGCDSIVVNQLVLKPSSEPPCRMCSARQKIQAKYLEQIDLLYEDFHVVKMPLLSDEVRGVPALKKFARFLQEPYSPDTHGYIDVQEPC
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: Y74_SIRV1
Sequence: MNYLKMSEQKKKSNLNTELTAKLYLALDDLTMALATEDKEEVRKSEVFQKALEVVKVVKEMRRLQVKPAEGEEK
What are the official names of this protein?
Uncharacterized protein 74.
Protein: SYDND_PELPB
Sequence: MSKAAGSTQTLKNRFRSDYCGLLCPEREHGSVRLAGWVHRKRDHGGLIFIDLRDHTGISQLVIQPEQQELFAKAEQLHVESVICIEGVVVLRAPGAINSRLASGEIEVVVSQITVESNAHPLPFPVADEVVTSEELRLKYRFIDLRREKIHENIIFRSRLTAAIRRYLEEQDFIEIQTPILTSSSPEGARDFLVPSRLHPGKFYALPQAPQQFKQLLMVSGFPRYFQIAPCFRDEDARADRSPGEFYQLDMEMAFIEQNDLFTILEGMIEHLTRTMSHKRITQFPFPRISYKEVMNRFGTDKPDLRIPLEISDVTPLFVGSAFKVFANSTVEGSCVKALVVKGRGNESRLFYDKAEKRAKELGSGGLAYIQFREEGPKGPVVKFLSEADLATLKEHLGLETGDVVFFGAGKWESTCKIMGGMRTYFGDLFTLDKDELSFCWIVDFPMYEYNEEAKKIDFSHNPFSMPQGEMEALETMPPLDILAYQYDIVCNGIELSSGAIRNHKPEIMYKAFGIAGYSREEVDARFGHMIEAFKLGAPPHGGIAPGLDRLVMILCDEQNIREVIAFPMNQQAQDLMMGSPSEVTPVQLKELHLKVELPKK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALT9_ALTAL
Sequence: MTFDYARRYMPEDQTGKTTVVGNMVAGMCAGVAESVLVLTPGENLKTRLIDDRAGARLYQSSTHAIRTIVTKDGASTFFRGVLPVTLKQSNSSMVRFTSYNQLAPMLQPTCGVSTSVVAGALAGVITVYCTMPFDNVKTQMQSLDGSRIYSSSWDCAKKLVVNGGPRRLWKGTTPRLLRLSVAGAIAFTLYEEVVRLTGFLVLPKVAAKAPKDAA
What is the function of this protein?
Tricarboxylate transporter; part of the gene cluster that mediates the biosynthesis of the host-selective toxins (HSTs) AAL-toxins, sphinganine-analog mycotoxins responsible for Alternaria stem canker on tomato by the tomato pathotype (PubMed:18435561, PubMed:19749175, PubMed:19449880).  The biosynthesis starts with the polyketide synthase ALT1-catalyzed C-16 carbon chain assembly from one starter acetyl-CoA unit with malonyl-CoA extender units (PubMed:18435561, PubMed:19449880).  ALT1 also selectively transfers methyl groups at the first and the third cycle of chain elongation for AAL toxin (PubMed:19449880).  The C-16 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of glycin by decarboxylation, on the carbonyl carbon of polyketide acyl chain (Probable).  This step is probably catalyzed by a pyridoxal 5'-phosphate-dependent aminoacyl transferase ALT4 (Probable).  The respective functions of the other enzymes encoded by the cluster have still to be elucidated (Probable).  The sphingosine N-acyltransferase-like protein ALT7 seems not to act as a resistance/self-tolerance factor against the toxin in the toxin biosynthetic gene cluster, contrary to what is expected (Ref. 5).
What are the official names of this protein?
Tricarboxylate transporter ALT9, AAL-toxin biosynthesis cluster protein 9.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PLSX_HELPS
Sequence: MKIVIDLMGADHGVLPIIEGVSRALENKSFSAVLVGDKDKATPFISKELASKVEMIHTQDYIKMEEVATEAIKRKESSIYLGMDILKNGADALISAGHSGATMGLATLRLGRIKGVERPAICTLMPSVGKRPSVLLDAGANTDCKPEYLIDFALMGYEYAKSVLHYDSPKVGLLSNGEEDIKGNMLVKETHKMLKAYDFFYGNVEGSDIFKGVVDVVVCDGFMGNVVLKTTEGVASAIGSIFKDEIKSSFKSKMGALMLKNAFDILKQKTDYAEYGGAPLLGVNKSVIISHGKSNARAIECAIYQAISAVESQVCLRITKAFESLKPSVSVPQSDQQDA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: DUOX2_PIG
Sequence: MLCIRPEALVLLGALLTVPLDPVGGQDALSLTWEVQRYDGWFNNLRQHEHGAAGSPLRRLVPANYADGVYQALGEPLLPNPRQLSHTTMRGPAGLRSIRNRTVLGVFFGYHVLSDLVSIEKPGCPAEFLNIHIPPGDPVFDPHKSGDVVLPFQRSRWDPNTGQSPSNPRDLTNEVTGWLDGSAIYGSSHSWSDELRSFSGGQLASGPDPAFPRQAQDPLFMWTPPDPATGQRGPQGLYAFGAEQGNREPFLQALGLLWFRYHNLCAQKLAREHPLWGDEELFQHARKRVIATYQSITMYEWLPSFLQQTPPNYTEYRPFLDPSISPEFLAASEQFFSTMVPPGVYMRNASCHFQMVLNESYGSFPALRVCNSYWIRENPNLNSAEAVNQLLLGMASQISELEDWIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYTQALQALGLNTPKNWSDFNPNVDPQVLEATAALYNQDLSRLELFSGGLLESYGDPGPLFSTIVLDQFVRLRDGDRYWFENTKNGLFSKEEIAEIRSTTLRDVLVAVTNVSSSALQPNVFIWNEDSPCPQPQQLTTEDLPHCVPLTVIQYFEGSGPGFGITIVALCCLPLMSLLISGVVAYFRSRERKKLQKRGKESVKKEADKDGVSAMEWPGPKERSYPVSIQLLPDRHLQVLDRHLSVLRTIQLRPRHRVNLILSNNLGRRTLLLKIPKEYDLVLLFNSEDERGAFVQHLQGFCASCALGLDIDEMGESELFRKAVTKQQRGRILEIFFRHLFAQVLDIDQADAGALPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDVLVVFMKGSPEDKSRLMFTMYDLDGNGFLSKDEFFTMIRSFIEISNNCLSKAQLTEVVESMFREAGFQDKQELTWEDFHFMLRDHDSELRHTQLCVKGGGGGVGVIFKPDISSRVSFIIRTPEERSSPQGVRLPASEASELGGPVLKKRFGKKAVVPPPRLYTEALQEKKQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICAGLFVERAYYYAFVSPPSGIAETTFVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNHYVPFDAAVDFHRWIAMAALVLAILHSVGHVVNVYIFSVSPLSLLACVFPSVFVNDGSKLPQKFYWWFFQTIPGMTGVLLLVVLAIMYVFASPYFRRRSFRGFWLTHHFYILLYVLLIIHGSFALIQLPRFHIFFLVPALIYVGDKLVSLSRKKVEISVVKAELLPSGVTHLQFQRPQGFEYKSGQWVRIACLGLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSHPMGDGYARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIREVEENDHRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKTCQLINRQDQTHFVHHYENF
What is the function of this protein?
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO.  Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa.  May have its own peroxidase activity through its N-terminal peroxidase-like domain.
What are the official names of this protein?
Dual oxidase 2, NADH/NADPH thyroid oxidase p138-tox.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the peroxidase family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell junction. Note=Localizes to the apical membrane of epithelial cells. Localizes on internal membrane structures under resting conditions, translocates to the plasma membrane and cell-cell junctions upon challenge with enteric pathogens.
Protein: FDHD_ESCF3
Sequence: MKKTQQKEIKNVTNITGVRQIELWRRDDLQHPRIDEVAEEVPVALVYNGISHVVMMASPKDLEYFALGFSLSEGIIESPRDIFGMDVVPSCNGLEVQIELSSRRFMGLKERRRALAGRTGCGVCGVEQLNDIGKPVQPLPFTQAFDLNKLDDALRHLNDFQPVGQLTGCTHAAAWMLPSGELVGGHEDVGRHVALDKLLGRRSQEGESWQQGAVLVSSRASYEMVQKSAMCGVEILFAVSAATTLAVEVAERCNLTLVGFCKPGRATVYTHPQRLIHN
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_DEHMC
Sequence: MPKKDAIEVEATVLEALPSAAFRVQLSNGHEVLAHISGKMRVHYIRILPGDRVLVELSPYDLTRGRVTYRFKS
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBT_NOSS1
Sequence: MESVAYILILTLAIGVLFFAIAFREPPRIEKKEEK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PLS8_PHYTM
Sequence: FLSLIPHAINAVSALAKHF
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Phylloseptin-8, PS-8, Phylloseptin-TO8, PLS-TO8.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YPA2_ASCIM
Sequence: SDFKNKLVISDFKYHCTFILGKDKVIKSVNVFELILFGIYKLSIFIPLFLIFIRLLATNILNFLFEVFKSIYSILKILFVVRFKPIRTHFLRPLSVSFIMISNNILLLISSLWYWLRVGKNLLLSTVGDGVGRFCKFRLPKPLLIDLVWNFLLFCFLCDRNFFIEFI
What are the official names of this protein?
Uncharacterized mitochondrial protein ORF2.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: COBS_DESVV
Sequence: MPTFLHHALLACGFLTRLVPARVATADDMAAAVRWFPLAGLVVGGACWLPFALGLAASHPAIQAWLYVLINLWVTRGLHWDGVADLADAWGSSATGERFWDILKDSRIGAFGVMGLLLGFGGQYIGAHEIFISGRLGVLIAAPIVGRGACVILAALVPPGSRSTLGRLTCAGADRIAIGVAATCGILVLLLTTPVMTTVTTIAICGAIVTALAHLARREGGINGDFMGACIAGCEGAVLLAASMG
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURB_STRP2
Sequence: MSVREKMLEILEGIDIRFKEPLHSYSYTKVGGEADYLVFPRNRFELARVVKFANQENIPWMVLGNASNIIVRDGGIRGFVILCDKLNNVSVDGYTIEAEAGANLIETTRIALRHSLTGFEFACGIPGSVGGAVFMNAGAYGGEIAHILQSCKVLTKDGEIETLSAKDLAFGYRHSAIQESGAVVLSVKFALAPGTHQVIKQEMDRLTHLRELKQPLEYPSCGSVFKRPVGHFAGQLISEAGLKGYRIGGVEVSEKHAGFMINVADGTAKDYEDLIQSVIEKVKEHSGITLEREVRILGESLSVAKMYAGGFTPCKR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_BURTA
Sequence: MQKRLTLLGSTGSIGDSTLDVVTRHPERFAVHALTAHRNGDKLVAQCLRFAPDVAVVGDAETAARVEAQLRAAGSKTQVAYGKQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKEALVMSGAIFMDAVRDHGAILLPVDSEHNAIFQCMPRDAAEHGGIAKIIVTASGGPFRTREPVTLASVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFGLPSERIDVLIHPQSVIHSLVSYCDGSVLAQLGNPDMRTPIAHALAFPERVDAGVAQLDLAQIATLTFEKPDYARFPCLALAIDALEAGGVASAALNAANEIAVDAFLSRRIRFTAIAQTVDAVLSGLSNRTPSGLDDVIGADADARRAATAFIDKLPAPSVERAA
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: PLA16_ARATH
Sequence: MAAIPSHNNLLTINHKNSITGSSSLNTNFSEINFPAKFRVATRALSRTDESSLSAVISRLERERRERQGLLIEEAEGAGELWMTAEDIRRRDKKTEEERRLRDTWRKIQGEDDWAGLMDPMDPILRSELIRYGEMAQACYDAFDFDPASKYCGTSRFTRLEFFDSLGMIDSGYEVARYLYATSNINLPNFFSKSRWSKVWSKNANWMGYVAVSDDETSRNRLGRRDIAIAWRGTVTKLEWIADLKDYLKPVTENKIRCPDPAVKVESGFLDLYTDKDTTCKFARFSAREQILTEVKRLVEEHGDDDDSDLSITVTGHSLGGALAILSAYDIAEMRLNRSKKGKVIPVTVLTYGGPRVGNVRFRERMEELGVKVMRVVNVHDVVPKSPGLFLNESRPHALMKIAEGLPWCYSHVGEELALDHQNSPFLKPSVDVSTAHNLEAMLHLLDGYHGKGERFVLSSGRDHALVNKASDFLKEHLQIPPFWRQDANKGMVRNSEGRWIQAERLRFEDHHSPDIHHHLSQLRLDHPC
What is the function of this protein?
Acylhydrolase with broad specificity (PubMed:19527719).  Catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position (PubMed:19527719).  Possesses moderate activity toward phosphatidylcholine (PC), monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG) and triacylglycerol (TAG) (PubMed:19527719).
What are the official names of this protein?
Phospholipase A1-Igamma2, chloroplastic, DAD1-like lipase 3.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
Protein: AROE_METM7
Sequence: MMDTKTKLLGLIGHPVDHSFSPIMHNTAIEDLGINYVYLAFDVSEENLKNVVSGAKALQITGFNVTIPHKINIMKYLDEIDEDAKAIGAVNTVKIENGKAIGYNTDGIGAKRTLEEKAGILIDKNILIIGSGGASRAVCFELAKDNNLTIINRNIEKAKILSEEFSKKLKKQKPINYGDLDLDIKNFDIILNTTPVGMHPNTNVDPVIPLKNIKKDAVVMDLIYNPIEPVFLKEAIKYGAKTINGLGMLVYQGAVSFEIWTGMKPDIYVMKKAINSKIRL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: PSBX_EMIHU
Sequence: MTPSLSAFLSSVILAVVVIVVPISAALVFVSTTDKIVRS
What is the function of this protein?
Involved in the binding and/or turnover of quinones at the Q(B) site of Photosystem II.
What are the official names of this protein?
Photosystem II reaction center X protein.
What is the protein family that this protein belongs to?
Belongs to the PsbX family. Type 1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MAZE5_MYCTU
Sequence: MKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDEALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Upon expression in M. smegmatis neutralizes the effect of cognate toxin MazF5.
What are the official names of this protein?
Antitoxin MazE5.
Protein: VE1_HPV04
Sequence: MADKGTDNFDLEGNNWYIVHEAECTDSIDTLDDLCDESNDDSNISNLIDDDVVDQGNSLALYNAQINEDCDNALAHLKRKYNKSPEQAVAELSPQLQAVKITPERHSKRRLFQDSGIFEDEAENSLTQVESESQAGPSSQDGGGDINLLLLQSSNRRATMLAKFKEWYGVSYNEITRIYKSDKSCSDNWVIVIFRAAVEVLESSKIVLKQHCTYIQVKIFGFSALYLVQFKSAKSRETVQKLMCSILNIQEYQMLCDPPKLRSVPTALYFYKHAMLTESSVFGQTPDWIAKQTLVSHQAATTAETFELSRMVQWAYDNNYVDECDIAYHYAMYAEEDANAAAYLKSNNQVKHVRDCSTMVRMYKRYEMRDMSMSEWIYKCCDECSEEGDWKPISQFLKYQGVNILSFLIVLKSFLKGIPKKNCIVIHGPPDTGKSLFCYSFIKFLKGKVVSYVNRSSHFWLQPLMDCKVGFMDDATYVCWTYIDQNLRNALDGNPMCIDAKHRAPQQLKLPPMLITSNIDIKQEQSLMYLHSRIQCFNFPNKMPILDDGSPMYTFTDGTWKSFFQKLGRQLELTDPEEENNGVPSRTFRCTSRSNSDSY
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PSYR_HUMAN
Sequence: MNSTCIEEQHDLDHYLFPIVYIFVIIVSIPANIGSLCVSFLQAKKESELGIYLFSLSLSDLLYALTLPLWIDYTWNKDNWTFSPALCKGSAFLMYMNFYSSTAFLTCIAVDRYLAVVYPLKFFFLRTRRFALMVSLSIWILETIFNAVMLWEDETVVEYCDAEKSNFTLCYDKYPLEKWQINLNLFRTCTGYAIPLVTILICNRKVYQAVRHNKATENKEKKRIIKLLVSITVTFVLCFTPFHVMLLIRCILEHAVNFEDHSNSGKRTYTMYRITVALTSLNCVADPILYCFVTETGRYDMWNILKFCTGRCNTSQRQRKRILSVSTKDTMELEVLE
What is the function of this protein?
Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (PubMed:11309421).  Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance (PubMed:27287411).  May have a role in activation-induced cell death or differentiation of T-cells (By similarity).
What are the official names of this protein?
Psychosine receptor, G-protein coupled receptor 65, T-cell death-associated gene 8 protein.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL29_BRUSU
Sequence: MKAADVRAKSLDQLNDELGTLKKEQFNLRFQKATGQLEKTARVKQVRRDIARIKTIARQKAAESKA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: T126B_RAT
Sequence: MASERPTGSESGDAGVVLEGNREASQDIKMALYKHGRLIPSLGDAKFGRPMIAEILEKKFESYRNDQTLNIRGTLFFGVSSSLSGVMANLVFRYSFKVKYEALRTYASLTTLPFVATAVTYKLFVTDALQSGNISQESCVLRSSLIGVACGVSYPSALAFYKNGRLAVKYHTVPVPPKGRVMLHWLLLCQTGMKAMAVPLLFQIIFGVFNGLYHYAVCEKAYARIVPDD
What is the function of this protein?
As part of the MCIA complex, involved in the assembly of the mitochondrial complex I (PubMed:22982022).  Participates in constructing the membrane arm of complex I (By similarity).
What are the official names of this protein?
Complex I assembly factor TMEM126B, mitochondrial, Transmembrane protein 126B.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: BLAB_PROVU
Sequence: MTMFKTTFRQTATIAVSLISLLVSPMLWANTNNTIEEQLSTLEKYSQGRLGVALINTEDNSQITYRGEERFAMASTSKVMAVAAVLKESEKQAGLLDKNITIKKSDLVAYSPITEKHLVTGMSLAQLSAATLQYSDNTAMNKILDYLGGPAKVTQFARSINDVTYRLDRKEPELNTAIHGDPRDTTSPIAMAKSLQALTLGDALGQSQRQQLVTWLKGNTTGDHSIKAGLPKHWIVGDKTGSGDYGTTNDIAVIWPKNHAPLILVVYFTQQEQDAKYRKDIIVKATEIVTKEISNSPQTK
What is the function of this protein?
Hydrolyzes broad-spectrum beta-lactam antibiotics.  Active against cephalosporins such as cefuroxime and cefotaxime.
What are the official names of this protein?
Beta-lactamase, Cefuroximase.
What is the protein family that this protein belongs to?
Belongs to the class-A beta-lactamase family.
Protein: PCNB_ECO57
Sequence: MFTRVANFCRKVLSREESEAEQAVARPQVTVIPREQHAISRKDISENALKVMYRLNKAGYEAWLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRNCRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNVSDRTTSQRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVRDYVGGMKDLKDGVIRLIGNPETRYREDPVRMLRAVRFAAKLGMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGYGYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWYPLLETAQKIAQESGLTYHDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLLEHPKFRAAYDLLALRAEVERNAELQRLVKWWGEFQVSAPPDQKGMLNELDEEPSPRRRTRRPRKRAPRREGTA
What is the function of this protein?
Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay.  Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
What are the official names of this protein?
Poly(A) polymerase I, PAP I.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
Protein: TRMB_CLOP1
Sequence: MRMRRKPWARPELEACDFFVANPKENKGNWKNTFKNTENPIYLELGCGKGTFMAVHGSDHPNINYIAIDIKDEVLVLAKRNIEKAYEEKNKALDNVKLMPQEIALIDTILDSNDKIERIYINFCNPWPKDRHKKRRLTHTRQLTKYRDFLVDGGEIHFKTDDDELFEESLEYFKECNFEITYITRDLHNSGYEYNVVTEHEEMFSKQGIKIKFLIAKKL
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: VPR_HV1MV
Sequence: MEQALENQGPAREPFNEWTLELLEELKEEAVRHFPRPWLQACGQYIYETYGDTWEGVMAIIRILQQLLFTHYRIGCQHSRIGILPSNTRGRGRRNGSSRS
What is the function of this protein?
During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus.  This function is crucial for viral infection of non-dividing macrophages.  May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.
What are the official names of this protein?
Protein Vpr, R ORF protein, Viral protein R.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPR protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host extracellular space. Note=Incorporation into virion is dependent on p6 GAG sequences. Lacks a canonical nuclear localization signal, thus import into nucleus may function independently of the human importin pathway. Detected in high quantity in the serum and cerebrospinal fluid of AIDS patient.
Protein: TRHO_BACAC
Sequence: MATTKPYRVLLYYMYTTIENPEEFAAEHLEFCNSLELKGRILVAKEGINGTCSGTVEQTEKYMEAMNNDPRFDGIVFKIDEADGHAFKKMHVRPRPELVTLRLEDDINPHEITGKYLEPKDFYEAMKQEDTVIIDARNDYEFDLGHFKGAIKPDIESFRELPDWIRENKEVLEGKKILTYCTGGIRCEKFSGWLVREGYEDVSQLHGGIVTYGKDPEVQGELWDGQCYVFDERIAVPVNQKEHVIVGKDHFTGEPCERYVNCANPECNKKILCSEENEAKYLRACSHECRVSPRNRYVIQHELTEEQVAAALEKIEAGK
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.