PharMolix/UniProtQA huggingface dataset:
Protein: TRPB_HALSA
Sequence: MSTNTDDTTRTDGTFGDYGGQYVPEVLMPAVEELTDAYERYVLDNEDGFVDDFRQRIRSFGGRPTPLTHAPTLSQRHGVDVYLKREDLLHGGAHKLNNALGQVLLAKYMGKDRIVAETGAGQHGTATAMACAALEMPCEIYMGRTDVNRQRPNVFRMRLHDADVNPVTVGSGTLKEAINETMRDWATNVADTHYVIGSVVGPHPFPSMVRDFQAIISEELRAQSREQLGELPAAVIACAGGGSNTMGAFGAFVGSASLPGAPAGTHEPAPDVDLLAVEAGGSRLGVDDDAGYAPNSASLSTGTEGVLHGARTKLLQTETGQIVESHSVSAGLDYAGVGPELAHLVDTGRITPTNVDDDAALAAFHRLSRDEGVIPALETSHAVAALDQYDGDGPVVVNVSGRGDKDLDTVIEASAANDIDAAPDMEVFEQ
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: RECA_CUPNE
Sequence: MDDKKAGAGVSAEKQKALAAALSQIEKQFGKGSIMRLGDGEIEQDIQVVSTGSLGLDIALGVGGLPRGRVVEIYGPESSGKTTLTLQVVAEMQKLGGTCAFIDAEHALDVQYAGKLGVDVGNLLISQPDTGEQALEITDALVRSGSIDLIVIDSVAALVPKAEIEGEMGDSLPGLQARLMSQGLRKLTGTIKRTNCLVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGSIKKGDEVVGNETKVKVVKNKVSPPFREAFFDILYGQGISRQGEIIDLGVDAKIVEKAGAWYSYNGEKIGQGKDNAREYLRENPDIADEIENKVRLALGVAPLNTVAGAPAEVEG
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYN_SHEFN
Sequence: MSIASVASVFKGEHAVGSQVTVRGWVRTRRDSKAGISFLAVYDGSCFDPIQGVLPNSLANYNDDVLKLTAGCSVVMTGEVVASPGAGQAFELQVTEIVVTGFVDDPDTYPMSAKRHSIEHLRELAHLRPRTNIIGAVARVRNCLSQAIHRFYHQEGFIWVSTPLITASDCEGAGEMFRVSTLDMENLPRTAEGKVDYDKDFFGKESFLTVSGQLNAETYACALSKVYTFGPTFRAENSNTTRHLAEFWMVEPEVAFATLDDAAELAEKMLKFAFSAVLEERMDDLNFFNERVDKTVIERLQAFVSSDFAQVDYTDAVEILKNCGKKFEFAVEWGIDLQSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNDDGKTVAAMDVLAPGIGEIIGGAQREERLDVLDARLAEMDLSQEDYWWYRDLRRYGTVPHSGFGLGFERLVSYVTGVNNIRDVIPFPRAPRSASF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LECA_DIOGR
Sequence: ADTIVAVELDSYPNTDIGDPNYPHIGIDIKSIRSKSTARWNMQTGKVGTVHISYNSVAKRLSAVVSYSGSSSTTVSYDVDLNNVLPEWVRVGLSATTGLYKETNTILSWSFTSKLKTNSIADENSLHFSFHKFSQNPKDLILQGDAFTDSDGNLELTKVSSSGDPQGNSVGRALFYAPVHIWESSAVVASFDATFTFLIKSPDREPADGITFFIANTDTSIPSGSGGRLLGLFPDAN
What is the function of this protein?
D-mannose/D-glucose-binding lectin.  Has anti-inflammatory activity in rats.  Induces histamine release in mast cells from rat.  Induces lymphocyte proliferation and IFNG production.  Shows toxicity against the aquatic snail B. glabrata at concentrations higher than 50 ug/ml.
What are the official names of this protein?
Lectin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: TRUD_CAMJD
Sequence: MNLAEENTIFKPLYSLKHSSINAYFSKNSDDFVVRERPLYEFSGKGEHLILHINKKDLSTNEALKILSEQSGVKMRDFGYAGLKDKQGSTFQYLSIPKKFESFLSNFSHSKLKILETFTHENKLRIGHLKGNSFFIRLKKVMPSDALKLEQVLMNLDKQGFANYFGYQRFGKFGDNYKEGLEILRGKKMKNIKMKEFLISAFQSDLFNRYLSKRVELSHFANDFSEKELLQIYKISKEEAKELKKQEQFFKLLKGEVLGHYPFGKCFLCEDLSAELERFRARDISAMGLLIGTKAYETGEGLALNLENEIFKDALEFKAKMQGSRRFMWRYLEELKWRYDEEKAHFCIEFFLQKGSYATVVLEEILHKNLPE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: CARP_ARTOC
Sequence: MKGSLLLAGATLLGCTSAKLHSLKLKKVSLKEQLEHADIDVQIKSLGQKYMGIRPGQHEQQMFKEQTPIEAESGHNVLIDNFLNAQYFSEISIGTPPQTFKVVLDTGSSNLWVPGKDCSSIACFLHSTYDSSASSTFTRNGTSFAIRYGSGSLEGFVSQDNVQIGDMKIKNQLFAEATSEPGLAFAFGRFDGILGMGYDTISVNKITPPFYKMVEQGLVDEPVFSFYLGDTNKDGDQSVVTFGGADKSHYTGDITTIPLRRKAYWEVEFNAITLGKDTATLDNTGIILDTGTSLIALPTTYAEMIISKSWNGQYTIDCAKRDSLPDLTFTLSGHNFTIGPYDYTLEVSGTCISSFMGMDFPEPVGPLAILGDSFLRRWYSVYDLGKGTVGLAKAK
What is the function of this protein?
Vacuolar aspartic endopeptidase which is probably also secreted and contributes to virulence.
What are the official names of this protein?
Vacuolar protease A, Aspartic endopeptidase PEP2, Aspartic protease PEP2.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Vacuole lumen. Secreted.
Protein: CAN13_RAT
Sequence: MAHDTEALEETSVVKFKNQDFRFLRDRCLSRGQLFIDDTFPAEASSIGQKLLMGKRLPKLEWKRPQDLSFGPPHFILEGASRFDIQQGRAGDCWFLAALGSLTQNPQCLQKILMNQSFSYQYAGIFHFRFWQCGQWVEVVIDDRLPVVGNNFCFVHPRRGNQEFWPCLMEKAYAKLLGSYSQLHYGYLPDALVDLTGGVVTRINLHSSPSDLLMVVKTAVQTGSMVACATPKWLTEESEVMENGLVSQHAYTVTGAEKIQYRRGWEEIIRLWNPWGNTEWRGRWGDGSQEWWETHGSRKSQLYENKDDGEFWMSCRDFHENFSCLYICSQFPITMDPGVTPNESWRQMRFKNQVISGNTAGGDGRDIQYLFDVQEPMDGNNVIVAFTVMPQSLKTEEWPFPLQFQVFKVDSQFQKFQKRLPPAFFSQFRDAAQGIDYVTKRNFTKSFHLSPGTYVVVASAHGKEVEFLLRIFLKMPHKDRNPNSSFNLKALKGSLSENESPKSSFHRYMDQGLDIDASQLQSLLNQEYLTGPPGDTFSLDQCQSIMALMDLKVNGRLDREEFARLQSRLIHCQHVFQHIQRSQGVLRSSDLWEVIESTDFLSGVLLSKELLSLMTLRYSDSSGRLSFPSLVCFLIRLETMSKAFRNLSKDGKSIYLTEMEWMKLVMYS
What is the function of this protein?
Probable non-lysosomal thiol-protease.
What are the official names of this protein?
Calpain-13, Calcium-activated neutral proteinase 13, CANP 13.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
Protein: ATX2_MOUSE
Sequence: MRSSTAAVQRPAAGDPEPRRPAGWAARRSLPRTARRGGRGGAVAYPSAGPPPRGPGAPPRGPRSPPCASDCFGSNGHGASRPGSRRLLGVCGPPRPFVVVLLALAPAATPARACPPGVRASPPRSGVSSSARPAPGCPRPACEPVYGPLTMSLKPQPQPPAPATGRKPGGGLLSSPGAAPASAAVTSASVVPAPAAPVASSSAAAGGGRPGLGRGRNSSKGLPQPTISFDGIYANVRMVHILTSVVGSKCEVQVKNGGIYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESVLFKCSDFVVVQFKDTDSSYARRDAFTDSALSAKVNGEHKEKDLEPWDAGELTASEELELENDVSNGWDPNDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKARVALENDDRSEEEKYTAVQRNCSDREGHGPNTRDNKYIPPGQRNREVLSWGSGRQSSPRMGQPGPGSMPSRAASHTSDFNPNAGSDQRVVNGGVPWPSPCPSHSSRPPSRYQSGPNSLPPRAATHTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSSEGPPRMSPKAQRHPRNHRVSAGRGSMSSGLEFVSHNPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTHRPRSPRQSSIGNSPSGPVLASPQAGIIPAEAVSMPVPAASPTPASPASNRALTPSIEAKDSRLQDQRQNSPAGSKENVKASETSPSFSKADNKGMSPVVSEHRKQIDDLKKFKNDFRLQPSSTSESMDQLLSKNREGEKSRDLIKDKTEASAKDSFIDSSSSSSNCTSGSSKTNSPSISPSMLSNAEHKRGPEVTSQGVQTSSPACKQEKDDREEKKDTTEQVRKSTLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSSAAQFGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNAALHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQSSFPAAQQTVFTIHPSHVQPAYTTPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGPKAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL
What is the function of this protein?
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
What are the official names of this protein?
Ataxin-2, Spinocerebellar ataxia type 2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the ataxin-2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLOT1_MOUSE
Sequence: MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYELKKATYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYRLERLAEAEKAQLIMQAEAEAESVRMRGEAEAFAIGARARAEAEQMAKKAEAFQMYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILSRLPESVERLTGVSISQVNHNKPLRTA
What is the function of this protein?
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
What are the official names of this protein?
Flotillin-1.
What is the protein family that this protein belongs to?
Belongs to the band 7/mec-2 family. Flotillin subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endosome. Membrane, caveola; Peripheral membrane protein. Melanosome. Membrane raft. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity). Membrane-associated protein of caveola (PubMed:9153235).
Protein: SYK_CHRVO
Sequence: MSDHEQAQAQSQDENQIMAERRQKLQAIREKGIAYPNDFKRSHFAKPLQDDHAAKEAEALEAEKIEVAVAGRMMLKRVMGKASFATLQDVSGRIQAFISRDNVGEDVYADFKRWDLGDIVAVKGMLFKTKTGELTVQATEVRMLSKNIRPLPEKFHGIADQETKYRQRYADLIMSEESRETFIKRSKIVQKVRDVMVGEGYLEVETPMMHPIPGGASAKPFVTHHNALDMPLYLRIAPELYLKRLVVGGLERVFEINRNFRNEGMSTRHNPEFTMIEFYEAYSDYQRMMEMTETIIRECALVACGSTTVTYQGKEVDLGKPFDRFTIVQAIKHYNPQYTDAQLSDAAWVASEIKRLGGKLPPAPGLGSLQLALFEECAESLLWNPTFIIDYPVEVSPLARGSDTQPGLTERFELFIVGREHANGYSELNDPEDQAARFQAQVAQKDAGDDEAMHYDADYIRAMEYGLPPTGGCGIGIDRLVMLLTDAPSIRDVILFPHMRPE
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EXD2_MOUSE
Sequence: MSRQNLVALTVTTLLGVAMGGFVLWKGIQRRWSKTSRVMQQQPQQPQQPQQPQPQPQPQPQPQPEHPQPQQQVPGGREWPPPEDDQLPFGALRAPRASWEERILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCALVRLPRLIYGGRTLPRTLLDILADGAILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMKQGNNILCNGLSLKSLAETILNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRDSYEEESTDQINWQKALERCRNMVDIPFRSKGLGRLVEEVNGEALESQLKPRNRKAKTDRMVPGNNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIITEEMLHEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDDLPIKLS
What is the function of this protein?
Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor.  In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+).  Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation.  Also involved in the response to DNA damage.  Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination.  Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.  Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation.
What are the official names of this protein?
Exonuclease 3'-5' domain-containing protein 2, 3'-5' exoribonuclease EXD2, Exonuclease 3'-5' domain-like-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the EXD2 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion matrix. Nucleus. Chromosome. Note=Mainly localizes to the mitochondrial outer membrane. May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidences. Recruited to replication forks following replication stress.
Protein: MPTA_HALSA
Sequence: MSQQLPDVQATEPDVSVGLSEVGVTGVEKLVEIAREDDRPIVLMAEFEVYVDLPRGRKGIDMSRNMRVIDETLEDAVREPIYRVEEMCGEVAERLLEKHDYTTTATVEMNAELMLREETPASDLPTQGTIDIIASATAQEDAPTREEIGARVVGMTVCPCSQQMMSETARRKLAELGVGEDAVREFLRDVPQAGHSQRGHATLTVEAGGDPDVNLMDLVSVARDSMSARIYNTAKRPDEDHMTYESHANAKFVEDCVRSMARGVVEEFDHLPEDAVVTMKQSNDESIHQHNAHAERVAEFGQLREEVGSGE
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: TTCA_PSEMY
Sequence: MGTLSVNQNKLQKRIRRLAGEAITDFNMIEDGDKVMVCLSGGKDSYTMLDVLLYLQKVAPIKFEIVAVNMDQKQPGFPEHVLPAYLESIGVAYHIIEKDTYSVVKEKIPEGKTTCSLCSRLRRGTLYTYADEIGATKMALGHHRDDILETFFLNMFYGGTLKAMPPKLLSDDGRNVVIRPLAYCAEADIEAYSQLKEFPIIPCNLCGSQENLQRQVVKEMLQEWERKSPGRVEIMFRALQNVHPSQLADRNLFDFKSLKIDDSATPRFLDVMSL
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_PARDP
Sequence: MRIGLYPGTFDPITLGHQDIIQRALELVDRLVIGVAINRDKSPLFALEDRVAMVREECDRIVAKRGGEIVVHPFENLLIDCARDVGATVIVRGLRAVADFEYEFQMVGMNRAMDDSIETVFLMADARRQAIASKLVKEIARLGGDVSKFVSPTVRDALVGRFAR
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PK3C3_RAT
Sequence: MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGRAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQASVSESLSSSGVSSADIDSSQIITNPLPPVASPPPASKSKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
What is the function of this protein?
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis.  As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding.  Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity).  Involved in the transport of lysosomal enzyme precursors to lysosomes (PubMed:11171063).  Required for transport from early to late endosomes (PubMed:11171063).
What are the official names of this protein?
Phosphatidylinositol 3-kinase catalytic subunit type 3, PI3-kinase type 3, PI3K type 3, PtdIns-3-kinase type 3, Phosphoinositide-3-kinase class 3.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family.
What are the subcellular locations of this protein?
Midbody. Late endosome. Cytoplasmic vesicle, autophagosome. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity).
Protein: DADA_BURCH
Sequence: MRVVILGSGVVGVASAYYLARAGHEVTVIDREAGPALETSFANAGQISPGYAAPWAAPGVPLKAVKWMFEKHAPLAIRLDGTRFQLQWMVQMLRNCTAERYAVNKGRMVRLAEYSRDCLQALRADTGIQYEGRTGGTLQLFRTQQQLDGAAKDIAVLQEANVPFELLSPAELKHAEPALAAVSHKLTGGLRLPGDETGDCQLFTTRLAALAESLGVKFRYNTPIDALAIAGGKIAGVQCGSETVRADAYVVALGSYSTNFISNLMKIPVYPLKGYSITAPIVDAAAAPVSTVLDETYKIAITRFDQRIRVGGMAEIVGFDKTLRAARRETLEMCVNDLFPGGGDTSKATFWTGLRPMTPDGTPIVGRTPVSNLFLNTGHGTLGWTMSCGSGQLLADLISGKKPAIQADDLSVHRYLKDAPGQTRPAYA
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: LEU1_BACSU
Sequence: MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAGFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATSDIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEFLSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDYRIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMSGLKNHTAVGS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: DER_CHLPN
Sequence: MLKIAILGRPNVGKSSLFNRLCKRSLAIVNSQEGTTRDRLYGELHAFGVPAQVIDTGGVDHNSEDYFQKHIYNQALTGAKEADVLLLVIDIRCGITEEDAHLAKLLLPLKKPLILVANKADSRQEELQIHETYKLGIRDIVVTSTAHDKHIDTLLQRIKLVANLPEPREEEEEGLEELSVDEHEESEAALPSNTFPDFSEVFTEGFSPEEPCTIPESPQQAPKTLKIALIGRPNVGKSSIINGLLNEERCIIDNTPGTTRDNIDILYSHKDRQYLFIDTAGLRKMKSVKNSIEWISSSRTEKAISRADICLLVIDATQKLSSYEKRILSLISKRKKPHIILINKWDLLEEVRMEHYCKDLRATDPYLGQAKMLCISATTKRNLKKIFSAIDELHHVVSNKVPTPIVNKTLASALHRNHPQVIQGRRLRIYYAIQKTTTPLQFLLFINAKSLLTKHYEYYLKNTLKSSFNLYGIPFDLEFKEKPKRHN
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: NAPC_HAEIN
Sequence: MSEKKPNILKRFWQWFRKPSRMAIGTIIILSAIGGILSWVGFNYGLEKTNTEQFCASCHMQDAYPEYLHSVHYQTRTGVGASCPDCHVPHEFGAKMKRKIIAAKEVYAHYTGKVDTLEKFNAHRLEMAQNEWARMKANDSKECRNCHNVDRMTFNDQRSVAARMHQKMKTEGKTCIDCHKGIAHQLPDMSGVESGFKDEK
What is the function of this protein?
Mediates electron flow from quinones to the NapAB complex.
What are the official names of this protein?
Cytochrome c-type protein NapC.
What is the protein family that this protein belongs to?
Belongs to the NapC/NirT/NrfH family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: XYN3_MAGGR
Sequence: MQILTWALAALAAIPAVTAAPVETVEASSMDELVERSPNVTLVARGTPSSTGTHNGFYYSHWTDNAGADVTYSMGGGGQFSYTWRNSGNFVGGKGWNPGNAGRVINYSGSYSPQGNSYLAVYGWTRNPLIEYYVVESFGSYNPSSGATNRGSFTSDGSTYDILVSTRYNQPSIDGTKTFQQFWSVRRNKRASGTVTFANHVNAWRNAGLNLGNQWNYQILAVEGYHSSGSASMTVR
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
What are the official names of this protein?
Endo-1,4-beta-xylanase 3, Xylanase 3, 1,4-beta-D-xylan xylanohydrolase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 11 (cellulase G) family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEMA_I68A6
Sequence: MKTIIALSYIFCLALGQDLPGNDNNTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPDSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGQSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQRGNIRCNICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: COBD_STUS1
Sequence: MSVFLSVIGALLLDALLGEPKRAHPLVAFGRLADRLEQHFNGAAGRGWRSHGVTAWCLAVLPLTLLAWLLSLLPGIGWLAEIVLLYLALGLRSLGEHALPVAQALWRHDLPEARRRVACIVSRDTSQLDEEGVARAATESVLENGSDAVFAALFWFIVAGAPGVVLYRLSNTLDAMWGYRNARFERFGWAAARIDDLLNYVPARLVAVTYALLGRTRRALRCWRTQAPLWDSPNAGPVMAAGAGALGVVLGGAAIYHGELHARPELGRGSAPQARHIEHALDLVWAGVGVWLLVLLFGGWLYA
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
Protein: XERD_CORGL
Sequence: MKARVLAKTWLTHLAVERGLSANTLSNYRRDVERYCDWLEAAGLDDIRDITTAHVESYVKDLRRGIDGQQALSASSAGRALIVARGLHKFALMEGEVAADVAADVSPPAMGRHLPDTLSINEVALLIDAIPHSDIATPVDLRDRALVELLYGTGARISEAIGLAVDDVSEMPEVLRITGKGSKQRIVPFGSMAQQAVREYLVRARPALSKGKSHALFLNQRGGPLSRQSAWAVLKKTVERAGLDKDISPHTLRHSFATHLLEGGADVRVVQELLGHSSVTTTQIYTHITADSLREVWRGAHPRA
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.