PharMolix/UniProtQA huggingface dataset:
Protein: NSS_SFTSV
Sequence: MSLSKCSNVDLKSVAMNANTVRLEPSLGEYPTLRRDLVECSCSVLTLSMVKRMGKMTNTVWLFGNPKNPLHQLEPGLEQLLDMYYKDMRCYSQRELSALRWPSGKPSVWFLQAAHMFFSIKNSWAMETGRENWRGLFHRITKGQKYLFEGDMILDSLEAIEKRRLRLGLPEILITGLSPILDVALLQIESLARLRGMSLNHHLFTSPSLRKPLLDCWDFFIPVRKKKTDGSYSVLDEDDEPGVLHGYPHLMAHYLNRCPFHNLIRFDEELRTAALNTIWGRDWPAIGDLPKEV
What is the function of this protein?
Sequesters host STAT2 into viral inclusion bodies (Probable) (PubMed:29886262).  Impairs IFN-stimulated phosphorylation and nuclear translocation of host STAT2, thereby suppressing type-I IFN antiviral signaling (Probable) (PubMed:29886262, PubMed:28680969).  Sequesters host TRIM25, RIGI, TBK1/IKK complex components (TBK1, IKBKE/IKKE, and IRF3) and IRF7 into viral inclusion bodies, thereby inhibiting the IFN responses (Probable).  Inhibits TRIM25-mediated ubiquitination of the RIGI (PubMed:32471869).  The sequestration of IKBKE/IKKE, and IRF3 occurs via the interaction with TBK1 (PubMed:24335286).  Sequestration and inhibition of host TBK1 probably participates to the cytokine storm induced by the virus (PubMed:33288641).  Also inhibits the phosphorylation of host TBK1 (PubMed:28680969).  Interacts with host TNIP2 and promotes TPL2-TNIP2-p105 complex formation leading to IL-10 induction (PubMed:30617349).  By interacting with CDK1, induces host cell arrest at the G2/M transition to promote viral replication (PubMed:31852787).  Requested for the formation of the viral cytoplasmic inclusion bodies (PubMed:24335286, PubMed:27226560).
What are the official names of this protein?
Non-structural protein NS-S, NSs.
What is the protein family that this protein belongs to?
Belongs to the Bandavirus NS-S protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cytoplasmic vesicle. Note=Localizes to the viral cytoplasmic occlusion bodies.
Protein: WZZB8_ECOLX
Sequence: MRVENNNVSGQNLDPEQIDLIDLLVQLWRGKMTIIISVIVAIVLAIGYLVVAKEKWTSTAIVTQPDVGQIAGYNNAINVIYGSAAPKVSEIQSILIGRFSTTFSALAETLDNQEEPEKLTIEPTVKNQSLPLAVSYVGQSPEAAQKQLAQYIQQVDDQVNDELEKDLKDNIALRMKNLQDSLKTQEVVAQEQKELRIRQIQEALQYANQAQVTKPQIQQTQDVTQDTMFLLGSDALESMVKHEASRPLVFSSTYYQTRQNLLDIESLKVDDLDIHAYRYVMKPTLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNYNAK
What is the function of this protein?
Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS).  Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111/M92) and of 17 (in strain K12).
What are the official names of this protein?
Chain length determinant protein, Polysaccharide antigen chain regulator.
What is the protein family that this protein belongs to?
Belongs to the WzzB/Cld/Rol family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1281_MYCTO
Sequence: MSPLLEVTDLAVTFRTDGDPVTAVRGISYRVEPGEVVAMVGESGSGKSAAAMAVVGLLPEYAQVRGSVRLQGTELLGLADNAMSRFRGKAIGTVFQDPMSALTPVYTVGDQIAEAIEVHQPRVGKKAARRRAVELLDLVGISQPQRRSRAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILDVLKAARDVTGAGVLIITHDLGVVAEFADRALVMYAGRVVESAGVNDLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAGLAPGCPFAPRCPLVIDECLTAEPELLDVATDHRAACIRTELVTGRSAADIYRVKTEARPAALGDASVVVRVRHLVKTYRLAKGVVLRRAIGEVRAVDGISLELRQGRTLGIVGESGSGKSTTLHEILELAAPQSGSIEVLGTDVATLGTAERRSLRRDIQVVFQDPVASLDPRLPVFDLIAEPLQANGFGKNETHARVAELLDIVGLRHGDASRYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQEQFGLSYLFVSHDLSVVKHLAHQVAVMLAGTVVEQGDSEEVFGNPKHEYTRRLLGAVPQPDPARRG
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein MT1318.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: SYE_LEPIC
Sequence: MNQSKEVRTRFAPSPSGFLHVGGARTALFNYLYAKSQGGKFILRIEDTDQNRSTEDSFKIILESLKWLGVNWDEGPEVGGEYGPYIQSQRLNIYKEYTEKLLKEKKAYRCFCTQEELEAKKKQSEAMGVPYVYDGLHANMSDEEVQEKLKQGIPYSVRFKTPSKTLIINDIIQGKVKFETKLIGDFIIVKSDGFPSYNYAVVVDDALMKITHVIRGVGHLSNTPRQILLYEALGYNIPEFAHASEIVGMDGKKLSKRAGATSILAFRDLGYLPETFRNYMALLGWTSTDGREFLPGDELEKIFDVHRCSKSPSTFDVFKKPKGSDEEVVTNFSDLTQIAEAMNPKSKLNWLSNRTIRDLNISKVLENLLPFLMDRKDIPAEVKNVNNPILTSIVESVRVYLDNLTQAPDYVAEFFVTDLKIQSEETIGFLKDGEGPKVVNEFYEILKNSDPKTDEDYKNLMSKVGEVTGQKGKTLYMPIRAATTGKSAGLELPILFPLLGKEKLLQRIEKTSKETGISLSN
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYIC_MAGGR
Sequence: MQTSNYGSLPTSRSAVVLGNDERLRIERHLPLPALRPNEVLVQVKAVAINPCDYKMHQRFPCPGAVDGCDFAGVIVGVGPEVLKFGLGDRVCGAVHGSNPLRPESGSFTDYMTSESEFTLKIPAGLSFEQAVGMGVTGIGTLGMALFRTLQLPGSLDRPATKPRTVLVHGGSSSVGTMAIQLLRLLGHVPIATCSPKNFALARRFGAEEVFDYNSPDCAAAIKAYTKNTLSYILDPFTDAKSVDLCYKAMGRAGGRYCCLEMYPEYVLQRKSIKVGFVMGPLLLGHRLALSQGYERDEDPEMRAFGVEWYKDVQKMLDRGLLKRHPIKLLGDSFEALIEGVEMLQRKEVSGEKLVVALDSEQSKPVLTK
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of the mycotoxin pyrichalasin H, a tyrosine-derived cytochalasan that inhibits the growth of rice seedlings, but also inhibits lymphocyte capping and actin polymerization and alters cell morphology (PubMed:31099577) (Probable).  Pyrichalasin H is indicated as the responsible agent for the genus-specific pathogenicity of M. grisea toward crabgrass (PubMed:31099577).  The first step in the pathway is catalyzed by the O-methyltransferase pyiA which methylates free tyrosine to generate the precursor O-methyltyrosine (PubMed:31099577).  The hybrid PKS-NRPS pyiS, assisted by the enoyl reductase pyiC, are responsible for fusion of the O-methyltyrosine precursor and the polyketide backbone (PubMed:31099577).  The polyketide synthase module (PKS) of pyiS is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the O-methyltyrosine precursor (PubMed:31099577).  As the NRPS A-domain demonstrates substrate tolerance, pyiS can also use phenylalanine, tyrosine and even para-chlorophenylalanine as amino acid precursor, which leads to the production of novel cytochalasans, including halogenated cytochalasans (PubMed:31099577).  Because pyiS lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase pyiC (PubMed:31099577).  Reduction by the hydrolyase pyiE, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase pyiF then yield the required isoindolone-fused macrocycle (PubMed:32039410).  The tailoring cytochrome P450 monooxygenases piyD and piyG catalyze the hydroxylation at C-18 and C-7, respectivily, whereas the short-chain dehydrogenase/reductase pyiH reduces the carbonyl at C-21 in preparation for the transfer of an acetyl group by the acetyltransferase pyiB (PubMed:31099577).  These 3 reactions whose order is not clear yet, lead to the production of O-methylpyrichalasin J, a deacetylated pyrichalasin H (PubMed:31099577).  Finally, pyiB to converts O-methylpyrichalasin J into the final product pyrichalasin H via acetylation of C-21 (PubMed:31099577).
What are the official names of this protein?
Trans-enoyl reductase pyiC, Pyrichalasin H biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: PSAA_EQUPA
Sequence: KIIVEKDPVRTSFEKWAQPGHFSKTLAKGPNTTTWIWNLHADAHDFDSHTNDLEDISRKIFSAHFGQLSIIFIWLSGMYFHGARFSNYEAWLSDPTHIKPSAQVVWPIVGQEILNGDVGGGFQGIQITSGFFQLWRASGITNELQLYCTAIGALIFAGLMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLGWAGHQVHVSLPINQLLDSGVDPREIPLPHEFILNRDLLAQLYPSFSEGLTPFFNLEWSKYSDFLTFRGGLNPVTGGLWLTDTAHHHIAIAVLFLIAGHMYRTNWGIGHSIKEILEAHKGPFTGEGHRGLFEILTSSWHAQLAVNLAMLGSLTIIVAHHMYAMPPYPYLATDYGTQLSLFTHHMWIGGFLVVGAAAHAAIFMVRDYDPSTQYNNLLDRVIRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPIFAQWIQNTHALAPSLTAPNATASTSLTWGGGDLVSVGGRVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNSISVVIFHFSWKMQSDVWGSINEQGVISHITGGNFAQSATTINGWLRDFLWAQASQVIQSYGSSLSAYGLLFLGAHFVWAFSLMFLFSGRGYWQELIESILWAHNKLKVAPAIQPRALSIVQGRAVGVAH
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A1, PSI-A, PsaA.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PBPA_ECOLI
Sequence: MKFVKYFLILAVCCILLGAGSIYGLYRYIEPQLPDVATLKDVRLQIPMQIYSADGELIAQYGEKRRIPVTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLARNFFLSPERTLMRKIKEVFLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLNEMAVIAGLPKAPSTFNPLYSMDRAVARRNVVLSRMLDEGYITQQQFDQTRTEAINANYHAPEIAFSAPYLSEMVRQEMYNRYGESAYEDGYRIYTTITRKVQQAAQQAVRNNVLDYDMRHGYRGPANVLWKVGESAWDNNKITDTLKALPTYGPLLPAAVTSANPQQATAMLADGSTVALSMEGVRWARPYRSDTQQGPTPRKVTDVLQTGQQIWVRQVGDAWWLAQVPEVNSALVSINPQNGAVMALVGGFDFNQSKFNRATQALRQVGSNIKPFLYTAAMDKGLTLASMLNDVPISRWDASAGSDWQPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQNIVHTESLALGSASFTPMQVARGYAVMANGGFLVDPWFISKIENDQGGVIFEAKPKVACPECDIPVIYGDTQKSNVLENNDVEDVAISREQQNVSVPMPQLEQANQALVAKTGAQEYAPHVINTPLAFLIKSALNTNIFGEPGWQGTGWRAGRDLQRRDIGGKTGTTNSSKDAWFSGYGPGVVTSVWIGFDDHRRNLGHTTASGAIKDQISGYEGGAKSAQPAWDAYMKAVLEGVPEQPLTPPPGIVTVNIDRSTGQLANGGNSREEYFIEGTQPTQQAVHEVGTTIIDNGEAQELF
What is the function of this protein?
Cell wall formation.  Synthesis of cross-linked peptidoglycan from the lipid intermediates.  The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
What are the official names of this protein?
Penicillin-binding protein 1A, PBP-1a, PBP1a.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transpeptidase family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: RBSD_SALEP
Sequence: MKKGTVLNSEISSVISRLGHTDTLVVCDAGLPIPNSTARIDMALTQGVPSFMQVVDVVTREMQVEAAILATEIKQQNPQLHETLLTHLEQLQQHQGNTIKISYTTHEQFKKLTADSQAVIRSGECSPYANVILCAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN646_MOUSE
Sequence: MEDMPLSFSCSDCQRHFPNLPELARHRELRHSSAKQDGEEADGIPHPYGSHPENLANHQRNHETLFFPCTTCGKDFSNRLALQSHMRTHAPESHRRHGPPHAMETAPHLGSETMATDSWGQRLGSGEGWENQTKLVRETHDWESGADPRAASGTWEDPPTKQRQGLEMQPDSKGGTADWVPAVSSEGASPLPTPASNLLSNLEQYLAESVVNFTEAQEPTEPLPTEGERKYRCSECGKTYKHAGSLTNHRQSHTLGIYPCSICFKEFSNLMALKNHSRLHAQYRPYHCPHCPRAFRLPRDLLEHQQSHEGLKQEQPWEDKEMPTTNGHADERSWGQLSKTGMLNGSGELSSSGQLEDGGSEEYRPFCCGDCGRTYRHAGSLINHRKSHQTGIYPCSICSKQLFNAAALKNHIRAHHRPRQGAGEGGQSSVSSTALTSAENTPKVDEVPTASLDHRPYKCNECGRAYRHRGSLVNHRHSHRTGEYQCSLCPRKYPNLMALRNHVRVHCKATRRSTDPGTEGSPSPVKKEQHDPVGMEAAFHGDEEHACKREEEATSNPSMADRTVPQVCSICGMLFEDLKSLEHHSVTHREGEKSRTDSTVSPTRTFACQDCGKSYRHSGSLINHRQTHQTGDFSCGACAKHFHTMAAMKSHLRRHSRQWNRRRQKQDSGTGEVATLPPGGAWTLKLENDEDPDSSQDPLGESPCETEDNLERDGDCLQAGSRGNECVLKREEACFLGDKEGTEEGLEEREACFLDDLGTPGDECNETGFCGGLPGMDSDRKRGICHSDSSSHPADADTVWKAAATHTCSDCGDSFSHAAGLLSHRSCHPPGIYQCSLCPKEFDSLPALRSHFQTHRPGEVASAQPFLCCLCGMIFPGRTGYRRHLRQAHGASAMTEGSEEEEEGTAETASTHSPPLQLSEAELLNQLQREVEALDGAGYGHICGCCGQTYDDLGSLERHHQSQSSSNRTENVPSHLEGAGDATEMVADHGFEGTVTSVSEEGGDIKSEEGVGGTVADSLCMQAGESFLESHPRPFQCNQCGKTYRHGGSLVNHRKIHQTGDFICPVCSRCYPNLAAYRNHLRNHPRCKGSEPQMGPISEAGGCSEPQNAAEAGQEQAVIGQLQEELKVEPLEELAGVKEEVWEGTAVKEEELEQELETGCQTEVTSERPFSCEVCGRTYKHAGSLINHRQSHQTGHFGCQACSKGFSNLMSLKNHRRIHADPRQFRCSECGKAFRLRKQLANHQRVHAERRRSRGTQKLTREDRPFRCGQCGRTYRHAGSLMNHQCNPEASRYSCPFCFKTYSNRTALKDHQRVHSDSQQRRQSGCPQRAAAVRCTLCGCGFSGQGSLEQHLQEHEDTKLEVASGQGGQHATEGSEENLDDWGLEGRSDGTEVLQVEHETKRPGGHSQSPSSPACSGGTESTQQVGKVDGSQGDRGQMNHNGAWVLQDQLTKPEGKLEDTVSRNPCHLSESQSNGPTLRYRDSWKGADSGSQLQPESHCCSQCGKAYCQPDGLLNPSINGKDCHICLLCSKEFLNPVTTEIHNHTTAQRFACSNCSKVCESHSELATHMKTHAVEHSQMSGQMEKTRGPQAGMAEVGPPGPGKAQEAPSELPGDPEENGVPANGGQGIHFPAAEDKERPFCCAQCGRSYRHAGSLLNHQKAHTIGLYPCSLCPKLLPNLLSLKNHSRTHTDPKRYSCNICGKAFRTAARLQGHGRVHAPQEGPFTCSHCPRRFRHRISFLRHQQQHQEEWPVSSSGASVAPAASREDSSTASLPNPSPQWPADLSLSL
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 646.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
Protein: CP52M_STABO
Sequence: MLIKDIILTPMSLSAVAGLLPLLFVAFLVLHEPIWLLWYRYAARRHKCSMPRFIEKSFPLGIQRTMDMIKTAKSYTLLEVQYDRVFNKFKARTYLRQAPLQYQIFTIEPENIKTILATKFNDFGLGARFHTVGKVFGQGIFTLSGNGWKQSRSMLRPQFTKDQVCRIDQISSHAAELIKEMNRAMKVDQFIDVQHYFHKLTLDTATEFLFGESCESLNPENQSCIVARDGSEITAEQFVESYNFLLNYAFKRTLSSKVYWLFNSKEFRDHKKRAQSYIDYYVDKALYATSFAAENSIAEKDAAAESSGIYVFSLEMAKVTRDPVTIRDQIFNILIAGRDTTAATLSFAIHFLARNPDVFNKLREEVLDHFGTKEEQRPLSFELLKQAPYLKQVINEVLRLAPVLPLNFRTAVRDTTLPIGGGPEQKDPIFVPKGTAVYYSIYMVHRDIKYWGPDAHEFNPNRWENLKLDNVWAFLPFNGGPRICLGQQFALTELSLTLVRLLQEYSKIEMGPDFPESPRFSTTLTAQHAPPGVVVRFS
What is the function of this protein?
Catalyzes the first step of sophorolipid biosynthesis.  Catalyzes the terminal (at the omega-position) or subterminal (at the omega(-1)-position) hydroxylation of a fatty acid.  This converts the fatty acid to a substrate for the subsequent glycosyltransferase reactions (PubMed:23516968, PubMed:24242247).  Oleic acid is the preferred substrate, but it acts on various other C-16, C-18 and C-20 saturated and unsaturated fatty acids, namely palmitic, palmitoleic, stearic, linoleic, cis-9,10-epoxystearic, trans-9,10-epoxystearic and arachidonic acid (PubMed:24242247).
What are the official names of this protein?
Cytochrome P450 52-M1, CYP52-M1, Cytochrome P450 monooxygenase CYP52-M1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PFKA_CLOD6
Sequence: MKTIGLLTSGGDAPGMNAAIRAVVRSAIYYGCKVYGINRGYKGLLEEDLTEMNLSSVGDIIHRGGTILKSSRCEEFKTEEGRLKAVKILKKYKIDCLVVIGGDGSFAGAQKLSDLGFPAIGIPGTIDNDLAYTDYTIGFDTAMNTIIDAIGKIRDTSSSHERVNIVEVMGRHCGDLALYAGLAGGAETIIVPEVEITVDEVALRLKTTQKRGKRHSIIVLAEGVGSASDLEKELKKESGADLRVTVLGHVQRGGSPTVSDRILASRLGVRAVELLLDGKSARVVGIKENKIIDLEISEALAQKKVFDKEAYEMAKILSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_CHESB
Sequence: MAKTFTFELVSPERLLLSEEVEQVVIPGTEGEMTVMAEHAPVMTGIKPGVITVVRAGSEREQFVVFGGFADITPDGCRLLAESATRVKELDRADLARRIEEVRAEVQGARDHETRTKAEEFLGQLTTLEGALLPA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KLH12_DANRE
Sequence: MAPKDIMTNSHAKSILNAMNALRKSNTLCDITLRVEGTDFPAHRIVLAACSDYFCAMFTSELAEKGKSFVDIQGLTASTMEILLDFVYTETVLVTVENVQELLPAACLLQLKGVKRACCDFLNSQLDPSNCLGIRDFAETHNCLDLMQAAELFSQKHFAEVVQQEEFMLLSQSEVEKLIKCDEIQVDSEEPVFEAVLNWVKHNRKEREPYLPDLLEYVRMPLLTPRYITDVIDAEPLIRCSLPCRDLVDEAKKFHLRPELRSEMQSPRTQARLGAKEVLLVIGGFGSQQSPIDIVEKYDPKTREWSFLPNIARKRRYVATVALNDRVYVIGGYDGRSRLSSVECLDYTADEDGVWYSVATMNVRRGLAGATTLGDMIYVAGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGLIYCLGGYDGLNILNSVERYDPHTGHWTSVTPMANKRSGAGVALLNDHIYVVGGFDGTAHLSSVEVYNIRTDYWTTVANMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPVIDSWEVVTSMATQRCDAGVCVLREK
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.  The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division (By similarity).  Negatively regulates the Wnt signaling pathway, possibly via the targeted ubiquitination and subsequent proteolysis of dvl2 and dvl3 (PubMed:16547521).  Regulates convergent-extension movements during early embryonic development (PubMed:16547521).
What are the official names of this protein?
Kelch-like protein 12.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle.
Protein: TRPA_ECO45
Sequence: MERYESLFTQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEVLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAECEKVGVDSVLVADVPVEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKAFVQPMKAATRS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: EAF5_ASHGO
Sequence: MNISKVLILETLYELLLNGQTNRVSLVRLQADVNDHPMTKQLAHQWQTLKINDILDVIKLLFPKQTSLSDGQIIFYNLQIVEIRDTLLDVVRECQDTLVKDVKQLEQQYQAIKSHDDMKIRRERIMGMYRDTILAKLQSFQHFHRLYSKLDPSPVVRDMMDLERIKATSIENLSHLQHILQKCVTDSVMTTKAGSDRYREIILSQGELDDTVKFVRYAMDN
What is the function of this protein?
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A.  The NuA4 complex is also involved in DNA repair (By similarity).
What are the official names of this protein?
Chromatin modification-related protein EAF5.
What is the protein family that this protein belongs to?
Belongs to the EAF5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: R27AA_ORYSJ
Sequence: MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLADYNIQKESTLHLVLRLRGGAKKRKKKTYTKPKKQKHKHKKVKLAVLQFYKVDDATGKVTRLRKECPNAECGAGTFMANHFDRHYCGKCGLTYVYNQQA
What is the function of this protein?
Ribosomal protein RSP27a-1 is a component of the 40S subunit of the ribosome.
What are the official names of this protein?
Ubiquitin-40S ribosomal protein S27a-1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus.
Protein: DNAJ_VIBCM
Sequence: MSKRDFYEVLGVGRDASERDIKKAYKRLAMKYHPDRNSGDAGAAEKFKEVKEAYEILTDAQKKAAYDQYGHAAFEQGAGGFGGGGFGGGGADFGDIFGDVFGDIFGGGRRGGGPRAQRGSDLRYNMELSLEEAVRGCSKEIEVPTLVHCDACDGSGAKKGTSAQTCGTCHGHGQVQMRQGFFAVQQTCPTCHGKGKIIKDPCNVCHGQGRKQKTKTLNVKIPAGVDTGDRIRLSGEGEAGEMGAPAGDLYVQVHVKEHHIFERDGNNLYCEVPVSFAMAALGGEVEVPTLDGRVSLKVPAETQTGRMFRMRGKGVKGVRSAALGDLIVKLVVETPVNLSARQKELLKEFEESCGGEAATKHKPKAEGFFNGVKKFFDDLTS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y568_RICPR
Sequence: MTIRKFHYLILFITIIAICSLFRIKDRVSTLNYQLRSVIKQINSENNNINILKAEQAYLLLPTRLEKLAAAYLKLEIVKSYQMINDPLAPNIEQNIKFNHNISISKSNKWRYKRIMNNKYIQTVSSRVK
What are the official names of this protein?
Uncharacterized protein RP568.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MYH1_CANLF
Sequence: MSSDQEMAIFGEAAPYLRKSEKERIEAQNRPFDAKTSVFVAEPKESFVKGTVQSREGGKVTVKTEAGATLTVKEDQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEVTSGKIQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELIATDSAIDILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEFVTKGQTVQQVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAHFSLIHYAGTVDYNIGGWLDKNKDPLNETVVGLYQKSAMKTLANLFSGATAAEAEAGGGKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKESLAKAEAKRKELEEKMVALMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSNLQSKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRTLEDQVSELKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDSLVSQLSRGKLAFTQQIEELKRQLEEEIKAKSALAHALQSARHDCDLLREQYEEEQEGKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKTELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKHNIETVKSLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKAYKRQAEEAEEQSNVNLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE
What is the function of this protein?
Muscle contraction.
What are the official names of this protein?
Myosin-1, Myosin heavy chain 1, Myosin heavy chain 2x, MyHC-2x, Myosin heavy chain, skeletal muscle, adult 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.