PharMolix/UniProtQA huggingface dataset:
Protein: ILYS3_CAEEL
Sequence: MFVKSLVFLTIAVAYASADCLHCICMRESGCKPIGCNMDVGSLSCGYYQIKLPYYEDCGQPTKKSGETTEAAWKRCANDLSCATTCVENYYNRYKSQCAGTGQGACEVMARNHNGGPQGCKHSGTLGYWNGIKSCCGCS
What is the function of this protein?
Has bacteriolytic activity against Gram-positive bacteria.  Plays a role in defense against bacterial pathogens.  Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria.
What are the official names of this protein?
Invertebrate-type lysozyme 3, 1,4-beta-N-acetylmuramidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.
What are the subcellular locations of this protein?
Late endosome lumen. Recycling endosome lumen. Lysosome lumen. Secreted. Note=Predominantly localizes to the recycling endosomal network in the basolateral region of intestinal cells. Secreted in the intestinal lumen only during dauer arrest stage, aging, or starvation.
Protein: PYHD_NPVSE
Sequence: MYTRYSYNPALGRTYVYDNKFYKNLGSVIKNAKRKEHLLQHEIEERTLDPLERYVVAEDPFLGPGKNQKLTLFKEIRIVKPDTMKLVVNWSGKEFLRETWTRFMEDSFPIVNDQEIMDVFLVINMRPTRPNRCFRFLAQHALRCDPDYVPHEVIRIVEPVYVGTNNEYRISLAKKGGGCPVMNLHSEYTNSFEEFINRVIWENFYKPIVYVGTDSGEEEEILLELSLVFKIKEFAPDAPLYNGPAY
What is the function of this protein?
Major component of the virus occlusion bodies, which are large proteinaceous structures (polyhedra), that protect the virus from the outside environment for extended periods until they are ingested by insect larvae.
What are the official names of this protein?
Polyhedrin, Major occlusion protein.
What is the protein family that this protein belongs to?
Belongs to the polyhedrin family.
Protein: LYSK_PYRFU
Sequence: MISTEEKIEFLKRLVEIYSPTGKENGVAKFLIKSFENYGIEAYLDDVGNVIAVKKGKGPLILLAGHMDTVPGYIPVRIENGELWGRGAVDAKGPLATFFFATIESDANIIFAGLVDEEGFSKGAKNLEVPKPDYIIVGEPSGTNGVTIGYKGSLTVKFTETVEKVHGSIGVGAAEKLIEKWLTIAKYFGEGFNSLSGRIVKFVAYEREFDFFGEMIVNLRTPPGYMPPKEWDIIDFVPAYEVSRTSPLVRAFVRAIRKAGYKPKLKKKTGTADTNILGPKYGVDAIAYGPGDSKLDHTPYERIKLREYLEAIEILKNAILELSSND
What is the function of this protein?
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
What are the official names of this protein?
Putative [LysW]-lysine/[LysW]-ornithine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. LysK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLA_FRATN
Sequence: MKKIIICFIFVFSINISFADATSDLIDKIKNIHSMTANFNQKLIDGQTNNNLNSKGNMSLKKPQYFKWITTSPNNQEIVSNGTKLWIYDGDLDQLIIKKVSNDIAQFPYLILLSKNTNNINKLFTVTAQDNNSYILKPKNDQMIDSIKIKFTPNNQLEYLEISTSLNQFTKIEFNNVKTDVDISNTSFDFTAPQDTDIIDETKSA
What is the function of this protein?
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane.  Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
What are the official names of this protein?
Outer-membrane lipoprotein carrier protein.
What is the protein family that this protein belongs to?
Belongs to the LolA family.
What are the subcellular locations of this protein?
Periplasm.
Protein: METN2_PARXL
Sequence: MANLFDAPQFIEDAPSLAVNAESHTTATQPAVIFDDVGKVFANTRGVATAALANVTLNVARGEVFGIIGRSGAGKSTLLRLVNGLEKPSSGAVRVNGVSVGELDERGLVTLRRRIGMVFQHFNLLSAKTVRENIALPLKIAGVPKAAIEKKVDALLELVGLSAKRDAYPASLSGGQKQRVGIARALVTDPDILLCDEATSALDPETTQAILALLRDINQRLNLTVVLITHEMQVIREVCDTVAVIERGEVVETGPVWRVFGDPQHDATRALLRTLVHDLPTDLAERVKPLHDIAQADAQILLDVRFTGADAREPDLGGLASALSVEGGRVSFVHGGIDRIQGHAQGRLVVSAQVRANADSTVQAQIATLLERARRYANHVEVLGYV
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GUNE_RUMFL
Sequence: MRKRITSMITVISLTLCGTIGTYPHNANASAKEAFEDISKRSECTKVFDNDNGTYTAYSNTAPIHYLNNDEWKEIDNTLIEDSDDYYRNKDNSFNIYIPKEYSLGKNIKNPVIMNYDTFSLSTSITDIKMPDRPEEETFSEGVYADINNEVYTTIDNSAIAEGMKAALKKSASMATYHSIVEDIDLDIAVHNASVSESIIINKLESLPETITYSISVEDAIIKKTEDNRLQLIKDNEAVLILSPFTISDSSENVNVMQVEYDLTESEEGYEVTLYPAETVNRMSSPVMPLSLGSEYSYDRPFSTVYNSQASLHPSIIIIT
What is the function of this protein?
Hydrolyzes both carboxymethylcellulose and xylan.  Probably has a role in hydrolyzing oligosaccharides derived from cellulose, which are transported across the cell wall.
What are the official names of this protein?
Endoglucanase E, EGE, Cellulase, Endo-1,4-beta-glucanase E.
What are the subcellular locations of this protein?
Secreted.
Protein: HBOH1_RALPI
Sequence: MKTMQGKGSGRRLRGALLVTMAASGAIGLAGCGGSNDNTTTTTPTNVKPSFVGTVTVTHFDGVSDDLLTAGLGAAGLASATAPTVANATAPTAAELRRLAIYNNYRALVDTNAKGGYGTLYGPNVDASGNVTSGSGMVPGVEYVAYSDDGSGQQNVVLLVQIPDAFDAANPCIITATSSGSRGIYGAISTGEWGLKRKCAVAYTDKGTRAGPHDLATDTVPLQDGTRTTRAAAGSKAQFAAPLTDTQLAAFNLATPNRLAFKHAHSQRNPEKDWGRFTLQAVQFAFWAINDKLSGGSAPNGSALAVRPDNTIVIASSVSNGGGAAIAAAEQDTTHLIDGVAVGEPGLNLPASANVQVQRGGVTLPVTGKPLFDYVSYANAFRLCAALSSSVSGAPTQSFFAGNIGWPASVQANRCAALHANGLLSSTTTAAQADEALQKMRTYGWEPESDLVHASMAYFEIDPSVATTFGNALARASVLDNLCNFSFAAVDTSFHPTTVNATALAQLASTGNGIPPTTGVQLINNLAQGGATQSKQSVDSSGTQAANLDGALCLRKLLTGADAASQALQLGISQTLRTGNLGGRPALIVQGRNDALLPVNHGARPYLGLNAQVDTSSKLSYIEVTNAQHFDGFIDLVPGYDTLFVPLVLYEQRALDAVYANLKNGTPLPPSQVVRTTPRGGTAGSAPAIAATNVPNFTNTPAVADRISVSVSGGVATVSVPN
What is the function of this protein?
Participates in the degradation of poly-3-hydroxybutyrate (PHB).  It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.
What are the official names of this protein?
D-(-)-3-hydroxybutyrate oligomer hydrolase, 3HB-oligomer hydrolase, 3HBOH, Extracellular 3HB-oligomer hydrolase, e3HBOH.
What is the protein family that this protein belongs to?
Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.
What are the subcellular locations of this protein?
Secreted.
Protein: SAR1_YARLI
Sequence: MWIVNWFYDVLSSLGLWNKNAKLLFLGLDNAGKTTLLHMLKNDRMAVSNPTVHPTSEELSIGNCKFTTFDLGGHIQARRVWKDYFPEVNGIVFLVDAADPTRFAESKAELDSLLAIEQLKTVPFLILGNKIDMPQAVSELELKDALGLYQTTGKGKVPLEGNIRPIEIFMCSIVMRQGYGDGIRWLSQYV
What is the function of this protein?
Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.  SAR1 controls the coat assembly in a stepwise manner.  Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex.  These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles.  Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity).
What are the official names of this protein?
Small COPII coat GTPase SAR1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. SAR1 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PIAS3_MOUSE
Sequence: MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLTPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSAVQEGIQPESKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYGPSVITSLDEQDTLGHFFQYRGTPSHFLGPLAPTLGSSHRSSTPAPPPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD
What is the function of this protein?
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.  Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway.  Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.  Repressor of MITF transcriptional activity.  Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.  Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity).  Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity).
What are the official names of this protein?
E3 SUMO-protein ligase PIAS3, E3 SUMO-protein transferase PIAS3, Protein inhibitor of activated STAT protein 3.
What is the protein family that this protein belongs to?
Belongs to the PIAS family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with MITF in the nucleus (PubMed:11709556). Colocalizes with GFI1 in nuclear dots (PubMed:11060035). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349).
Protein: HMA8_ARATH
Sequence: MASNLLRFPLPPPSSLHIRPSKFLVNRCFPRLRRSRIRRHCSRPFFLVSNSVEISTQSFESTESSIESVKSITSDTPILLDVSGMMCGGCVARVKSVLMSDDRVASAVVNMLTETAAVKFKPEVEVTADTAESLAKRLTESGFEAKRRVSGMGVAENVKKWKEMVSKKEDLLVKSRNRVAFAWTLVALCCGSHTSHILHSLGIHIAHGGIWDLLHNSYVKGGLAVGALLGPGRELLFDGIKAFGKRSPNMNSLVGLGSMAAFSISLISLVNPELEWDASFFDEPVMLLGFVLLGRSLEERAKLQASTDMNELLSLISTQSRLVITSSDNNTPVDSVLSSDSICINVSVDDIRVGDSLLVLPGETFPVDGSVLAGRSVVDESMLTGESLPVFKEEGCSVSAGTINWDGPLRIKASSTGSNSTISKIVRMVEDAQGNAAPVQRLADAIAGPFVYTIMSLSAMTFAFWYYVGSHIFPDVLLNDIAGPDGDALALSLKLAVDVLVVSCPCALGLATPTAILIGTSLGAKRGYLIRGGDVLERLASIDCVALDKTGTLTEGRPVVSGVASLGYEEQEVLKMAAAVEKTATHPIAKAIVNEAESLNLKTPETRGQLTEPGFGTLAEIDGRFVAVGSLEWVSDRFLKKNDSSDMVKLESLLDHKLSNTSSTSRYSKTVVYVGREGEGIIGAIAISDCLRQDAEFTVARLQEKGIKTVLLSGDREGAVATVAKNVGIKSESTNYSLSPEKKFEFISNLQSSGHRVAMVGDGINDAPSLAQADVGIALKIEAQENAASNAASVILVRNKLSHVVDALSLAQATMSKVYQNLAWAIAYNVISIPIAAGVLLPQYDFAMTPSLSGGLMALSSIFVVSNSLLLQLHKSETSKNSL
What is the function of this protein?
Mediates copper transfer across the chloroplast thylakoid membrane.  Required for copper delivery into the thylakoids lumen, which is essential for the function of copper proteins.
What are the official names of this protein?
Copper-transporting ATPase PAA2, chloroplastic, Protein HEAVY METAL ATPASE 8.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: IREB2_HUMAN
Sequence: MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDWKTKQSNVEVPFFPARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSICVGNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEELSPGITLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARKFS
What is the function of this protein?
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA.  Binding to the IRE element in ferritin results in the repression of its mRNA translation.  Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
What are the official names of this protein?
Iron-responsive element-binding protein 2, IRE-BP 2, Iron regulatory protein 2, IRP2.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: RUTB_SHISS
Sequence: MPRPSPCADSGGGMMTTLTARPEAITFDPQQSALIVVDMQNAYATPGGYLDLAGFDVSTTRPVIANIQTAVTAARAAGMLIIWFQNGWDEQYVEAGGPGSPNFHKSNALKTMRKQPQLQGKLLAKGSWDYQLVDELVPQPGDIVLPKPRYSGFFNTPLDSILRSRGIRHLVFTGIATNVCVESTLRDGFFLEYFGVVLEDATHQAGPEFAQKAALFNIETFFGWVSDVETFCDALSPTSFARIA
What is the function of this protein?
Hydrolyzes ureidoacrylate to form aminoacrylate and carbamate.  The carbamate hydrolyzes spontaneously, thereby releasing one of the nitrogen atoms of the pyrimidine ring as ammonia and one of its carbon atoms as CO2.
What are the official names of this protein?
Ureidoacrylate amidohydrolase RutB.
What is the protein family that this protein belongs to?
Belongs to the isochorismatase family. RutB subfamily.
Protein: ITR1_SPIOL
Sequence: KCSPSGAICSGFGPPEQCCSGACVPHPILRIFVCQ
What is the function of this protein?
Trypsin inhibitor.
What are the official names of this protein?
Trypsin inhibitor 1, SOTI I, Trypsin inhibitor I.
What is the protein family that this protein belongs to?
Belongs to the Mirabilis serine proteinase inhibitor family.
Protein: MNME_BUCAP
Sequence: MIRNDTIIAQVTCPGKSAVGILRVSGIHANQVAFAVLGKIPKPRFATYSKFFDESKKVLDEGISLWFPAPFSLTGEDVLELQGHGNPFIMDLLIKRILCLKNIKIRIAQPGEFCQRAFLNGKIDLIQAEAIDDLINSETESVVRASLNSLHGNFSFYIQKIIKKLIEFRTNIEASIDFSEENIDFDFNIFIMSNFEKLNDKFLKIKNIVSEGSLIREAKRIVIVGPPNAGKSSLLNVLSCRDRAIVTDLPGTTRDVLYENINIHGISCEIIDTAGLRETEDKIEKIGIQRSWEMIKNSDHVLYVMDKTISLEDQKKTSIQFMKQISSYNIQEVTFVLNKNDLVEDFCGITKIENLLFISISALTGQGIDILKKHLSNRQKDKSQEGLFIARRRHIHQIDLSYCELLKAQKNWLKYKNIELLAESLNIINKLLGEITGEFTSSDLLKRIFSTFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PI42C_HUMAN
Sequence: MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
What is the function of this protein?
Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity.  May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity.  PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism.  They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
What are the official names of this protein?
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Cytoplasm.
Protein: MLA_HORSE
Sequence: SYSMEHFRWGKPV
What are the official names of this protein?
Melanotropin alpha, Alpha-MSH.
What is the protein family that this protein belongs to?
Belongs to the POMC family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS6_METS4
Sequence: MALYEHVFLARQDVTSQQVESMIEAYKGVIESNGGKVEKTEMWGVKSLAYRIKKNRKAHFTLLNIDAPPAALAEMERQMRISEDILRFLTIRVDALEGEPSAMMQKRDRDERKDRERGRRRDDDGYVGERNEEG
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: FSLK_DICDI
Sequence: MRVLFILFLFYFYTYTEAQQYYPIDPTGKCEQYIGDSVITPCNSIYVSSTANQSTAMLSLNLYFSLLGGSSASCQNAYTFATLCSTYLPECEIFIDNSTNKEIAMPKRVCLDTCNSVSKNCQITSYFDCNQLEPISKLPLFPKESSDYNLTTYGGELNYRLDCYDPPKSNETTVIGYCPFPLVFRNRTIVGKGSDSLDNSENYGYTYVSEDSYCTIPCPAPIFSEKQWDNIFDTSDAISLVSLLCSVYLFITYMVINPKRNKYDYFFSFFVLSIILMSIAGTIGFSVGGTRKLLCPEINRRGVYTDPAVAAAGWIFQFAIINAILWFSINSFELWFQIKFIKRKLHLIKFYILAVLVISIALSVPLSAIGEFNAGLGNFVVWIESGKYQNWFFWGPLGIVLTVGTTFIGLVIWEIYKIVSSTNKSDFFKLQLKPLMNMLLIYLTFVYLFGYNFYIHNSLNGFYGSSEEFKNCIISTDGKDCRIQGPPYSSILMFVFCLRIYGVYCIALYGFSPKTRSIWSNSIVFNNSMANKLKTLYISSGTTKGGTSSTDIKMSTNNNSNMDSGGGKSSSMEPDEIILR
What are the official names of this protein?
Frizzled and smoothened-like protein K.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YBHG_ECOLC
Sequence: MKKPVVIGLAVVVLAAVVAGGYWWYQSRQDNGLTLYGNVDIRTVNLSFRVGGRVESLAVDEGDAIKAGQVLGELDHKPYEIALMQAKAGVSVAQAQYDLMLAGYRDEEIAQAAAAVKQAQAAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLRQYRSGNREQDIAQAKASLEQAQAQLAQAELNLQDSTLIAPSDGTLLTRAVEPGTVLNEGGTVFTVSLTRPVWVRAYVDERNLDQAQPGRKVLLYTDGRPDKPYHGQIGFVSPTAEFTPKTVETPDLRTDLVYRLRIVVTDADDALRQGMPVTVQFGDEAGHE
What are the official names of this protein?
UPF0194 membrane protein YbhG.
What is the protein family that this protein belongs to?
Belongs to the UPF0194 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: UBP37_PIG
Sequence: MSPLKIQGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNVVLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLNAVAMKPSQGSGSFGAILGSRTSQKETHRQLSYSDNQVSSKRGSLETKDDIPFRKVLGNPGRASIKTAAGSGITATRTIPSLTSTSTPLRSGLLENRTEKRKRMLSSGSELNEDYPKENDSSSNNKAMTDPSRKYLTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAASKDYSPSSTNLDRTNISSQTPSAKRSLGFLPQPAPLSVKKLRCNQDYTGWNKPRLPLSSHQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALISRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVPGEENSPDVTATRVYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVRHKFNRLPRILILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPPFNLGWSAQMAISRPLKASQMVNSCITSPSTPSKNFTFKSKSSLALSLDSDSEDELKRSVALSQRLCEISSSEQQQEDLEKDSKSCKLEPDKSELENSGFDAMSEEELLAAVLEISKREASPSPSHEDDDKPTSSPDTGFAEDDIQEMPENPDPMETEKPKTITEPDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELSLQEFNNSFLDSLGSDEDSGNEDVLDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEASVQSDRDRSGYIFFYMHKEIFDELLETEKNSQALSMEVGKTTRQAS
What is the function of this protein?
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry.  Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex.  Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro.  Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).  Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 37, Deubiquitinating enzyme 37, Ubiquitin thioesterase 37, Ubiquitin-specific-processing protease 37.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: COF_ECOLC
Sequence: MESLPKTLSTLARLRERDITLTFATGRHALEMQHILGALSLDAYLITGNGTRVHSLEGELLHRDDLPADVAELVLYQQWDTRASMHIFNDDGWFTGKEIPALLQAFVYSGFRYQIIDVKKMPLGSVTKICFCGDHDDLTRLQIQLYEALGERAHLCFSATDCLEVLPVGCNKGAALTVLTQHLGLSLRDCMAFGDAMNDREMLGSVGSGFIMGNAMPQLRAELPHLPVIGHCRNQAVSHYLTHWLDYPHLPYSPE
What is the function of this protein?
Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
What are the official names of this protein?
HMP-PP phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. Cof family.
Protein: NADE_STAAR
Sequence: MSKLQDVIVQEMKVKKRIDSAEEIAELKQFIKSYVQSHSFIKSLVLGISGGQDSTLVGKLVQMSVNELREEGIDCTFIAVKLPYGVQKDADEVEQALQFIEPDEIVTVNIKPAVDQSVQSLKEAGIVLTDFQKGNEKARERMKVQFSIASNRQGIVVGTDHSAENITGFYTKYGDGAADIAPIFGLNKRQGRQLLAYLGAPKQLYEKTPTADLEDDKPQLPDEDALGVTYEAIDNYLEGKPVTPEEQKVIENHYIRNAHKRELAYTRYTWPKS
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: ARGC_PASMU
Sequence: MQKAIIIGASGYTGAELARLLIKHPEFELTGLYVSRQSQDANKCISDIYPQLKHLVDLPLQPLPEQLTQLAQQADLVFLATAHEVSHDLAPIFLQNQCKVFDLSGAFRVNNAAFYRTFYGFEHQHPELLTQAVYGLAEWNAHQIKQTDLVAVAGCYPTVSQLSLKPLIAHNLLDLTQLPVINAVSGVSGAGRKATLTSSFCEVSLNAYGVFNHRHQPEIATHLGTEVIFTPHLGNFKRGILATITAKLKTGVSDEQIRVAYQHAYADKPLVRVYEQGLPSIKAVEFTPYCDIGFVTKNGHIIIIGAEDNLLKGAAAQAVQCANIRYGLTETLGLL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_MYXXD
Sequence: MSAFTPREVVSELDRYIVGQNAAKRAVAIALRNRWRRQQVDDDLRDEIHPKNIIMIGPTGVGKTEIARRLAKLAQAPFVKVEASKFTEVGYVGRDVESMIRDLVEAAIALVREEETEKVGPRAEELAEDRLIELMQGGGVKSSSATPPFGFAPPPPPPVQRVSDSAREKFRAQLRAGTLDDVEVEVETAESSPTFMRGFSGQGMEEIGVNLQDLFKNVPGMNKTRRRRVRVPEALQLLRKEEAAKLVDPDRVQREAVARAEMNGIIFIDEIDKIASREGGKGGGGPDVSREGVQRDILPIVEGSTINTKYGVVKTDHMLFIAAGAFHVSKPSDLIPELQGRFPIRVELEPLTGEDLVRILREPKNSLLRQYTALLSTEGVRLSFTDDAVTELARIAQQANESTANIGARRLHTILERLLDEVSFSASEMGPRDFQVDAAYVRERLAAIVQDEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.