PharMolix/UniProtQA huggingface dataset:
Protein: NRDR_HALH5
Sequence: MRCPACHHNGTRVLDSRPAHEGRSIRRRRECESCNHRFTTFEMIEEVPLIVVKKDGTRQEFSSDKILRGLIRACEKRPVPLETLEGIVNEVERELRGQGKNEVDSKEIGELVMERLANVDDVAYVRFASVYRQFKDINVFIQELKELMERDDR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: PSBC_NICTO
Sequence: METLFNGTLALAGRDQETTGFAWWAGNARLINLSGKLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLATLGWGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGIYHALLGPETLEESFPFFGYVWKDRNKMTTILGIHLILLGLGAFLLVFKALYFGGVYDTWAPGGGDVRKITNLTLSPSIIFGYLLKSPFGGEGWIVSVDDLEDIIGGHVWLGSICILGGIWHILTKPFAWARRALVWSGEAYLSYSLGALSVFGFIACCFVWFNNTAYPSEFYGPTGPEASQAQAFTFLVRDQRLGANVGSAQGPTGLGKYLMRSPTGEVIFGGETMRFWDLRAPWLEPLRGPNGLDLSRLKKDIQPWQERRSAEYMTHAPLGSLNSVGGVATEINAVNYVSPRSWLATSHFVLGFFFFVGHLWHAGRARAAAAGFEKGIDRDFEPVLSMTPLN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL14_STRZP
Sequence: MIQTETRLKVADNSGAREILTIKVLGGSGRKFANIGDVIVASVKQATPGGAVKKGDVVKAVIVRTKSGARRADGSYIKFDENAAVIIREDKTPRGTRIFGPVARELREGGFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RL20_BLOPB
Sequence: MTRVKNSVVARARHKKILKQAAGYYGARSRTYRVAYQSVIKSGQYSYRDRRQKKRLFRRLWINRINAASRKYGMSYNHLINGLQKCNVCINRKMLADIAIFDRETFSALIDKAKINCEHT
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: 2B_CMVFN
Sequence: MELNVGAMTNVELQLARMVEAKKQRRRSHKQNRRERGHKSPSERARSNLRLFRFLPFYQVDGSELTGSCRHVNVAELPESEASRLELSAEDHDFDDTDWFAGNEWAEGAF
What is the function of this protein?
Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.  Suppresses RNA silencing by direct perturbation of host AGO1 slicer activity and thus interfering with miRNA pathways.
What are the official names of this protein?
Suppressor of silencing 2b, Protein 2b.
What is the protein family that this protein belongs to?
Belongs to the cucumovirus/ilarvirus protein 2b family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: AROB_PSESM
Sequence: MQTLKVELGERSYPIHIGEGLLDQPELLAPHIVGRQVAIVSNTTVAPLYLERLTQTLAGYNVLPIVLPDGEAFKNWETLQTIFDGLLTARHDRRTTVIALGGGVIGDMAGFAAACYQRGVNFIQIPTTLLSQVDSSVGGKTGINHPLGKNMVGAFYQPSVVLIDTTSLNTLPERELSAGLAEVIKYGLICDEPFLTWLEEHVDALRGLDQAALTVAIERSCAAKALVVGADERESGVRATLNLGHTFGHAIETHMGYGVWLHGEAVAAGTVMALEMSSRLGWISTQERDRGIRLFQRAGLPVVPPQEMTEDNFLEHMAIDKKVIDGRLRLVLLRQIGEAVITDDYPQEVLQATLVADYRALVDQLRG
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UXS1_RAT
Sequence: MVSKGLLRLVSSVNRRKMKLLLGIALFAYAASVWGNFVNMRSIQENGELKIESKIEEIIEPLREKIRDLEKSFTQKYPPVKFLSEKDRKRILITGGAGFVGSHLTDKLMMDGHEVTVVDNFFTGRKRNVEHWIGHENFELINHDVVEPLYIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLGLAKRVGARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYAYMKQEGVEVRVARIFNTFGPRMHMNDGRVVSNFILQALQGEPLTVYGSGSQTRAFQYVSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQLIKNLVGSGSEIQFLSEAQDDPQKRKPDIKKAKLMLGWEPVVPLEEGLNKAIHYFRKELEYQANNQYIPKPKPARVKKGRTRHS
What is the function of this protein?
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:11877387).  Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:11877387).
What are the official names of this protein?
UDP-glucuronic acid decarboxylase 1, UDP-glucuronate decarboxylase 1, UGD, UXS-1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein: RF1_ECO55
Sequence: MKPSIVAKLEALHERHEEVQALLGDAQTIADQERFRALSREYAQLSDVSRCFTDWQQVQEDIETAQMMLDDPEMREMAQDELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSASEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPDAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAEMAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDEVMEGKLDMLIEPIIQEHQADQLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_MYCA9
Sequence: MPKPTKGARLGGSSSHQKAILANLATALFEHGRIKTTETKARVLRPYAEKLITHAKKGDLHNRREVLKKIRDKDVVHALFEEIGPFYADRNGGYTRIIKVENRKGDNAPMAIIELVKEKTVTSEADRARRVASTKKAEAPAEEAKVEEVVEVEADTADDAAAEVEGAADTADAAEDADKKD
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: Y3600_YERPY
Sequence: MLIIISPAKTLDYQSPLATTKFSQPEMLDKSQALIEICRELTPAQISSLMGISDKLAGLNAARFSEWQPDFTPANARQAILAFKGDVYTGMQAESFSEADFDFAQQHLRMLSGLYGLLRPLDLMQPYRLEMGTKLANPRGKDLYAFWGDQITEKLNQALELQGDNILINLASDEYFKAVKPAKLSGSLIKPVFLDEKNGKYKIISFYAKKARGLMSRFIIQNKLTKPEQLVDFNLEGYEFDAGLSAKNELVFKRAEQH
What are the official names of this protein?
UPF0246 protein YPK_3600.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: RNH_XANC8
Sequence: MKSIEVHTDGSCLGNPGPGGWAALLRYNGREKELAGGEANSTNNRMELMAAIMALETLTEPCQILLHTDSQYVRQGITEWMPGWVRRGWKTSGGDPVKNRELWERLHAATQRHSIEWRWVKGHNGDPDNERVDVLARNQAIAQRGGLATS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UTP10_CRYNB
Sequence: MSSLAQQLQSIASLDAARLTSAYGAPSGKSYLFPPDVASSHDIDSIFDLAQSGFDELLSLDPEMEEFEEELFSESAKRTDRMVLSKEENDNLDRTLGRCLRRLGKWIRLMAGGKCIEWMVRRFRVHEMNVDEVLRSFLPYHESPNFPRILAIVTIPKTSPYYATFAPLVKDAQPIPRSYIVTSISPAKDKSLVLLGDIASMVQQAVKEGVVHHALLTFWTATMVDLLEGARHGKGANEGVVKQLVESFVTLLETPKAGEDVNAAVYPPLVLLTRTVPLADEPFLAIVSSLLTPGTGSNPSQRMLTLLVILNDRHTWSLGLGEHATENLAKVSQLGEILVAAMDKYRFEKALNIVVKSMLEKPDLHAKALATVLEHESLPTSVTELASTNLLQLGSSTDSQEVKAACKSLLTNLRERHPSIVDTAFLQASASLEIDTHPVDHGLVQKPSGEVAFLDVYAADISSRVTGVKSVIDMAKKGEEIESSITALEARLSDVDENVVNALYEEPKSLLEILPVEKYIAGVKPVFWAVSPISHIIGLHLDFISQHLLVSHPEAGKQIYESLLFPIFLSTEKRQPLTKSQALKLLNGGFKKLDKLSTIGPEIGKAREEGMKGAQKGNLVIAKALAGATLSSSTFEDDISFLIAQLDSTTSSARLLAYLILHSLVLTLRGPRQLSTSLSILKYLSPRLTGHSLRDLKHADENVNTEYMESVYKKPEETRTTLRAIVSILAAMGKVIKPIGQIVWLSGESKAKDASYKTFAQQIYLWANIAILPANVAHFLLRSLLTQLGEEALLFFSSIWTSSTSPVPLRISALKHALAFIHAYATLPTSPAAQGQPVDFQVVLPQILIALQDSDKDVRRVAVDVLRSVEGGEGMGDVYALDTIYGDRSEMTQLLKSVDRKKYIETLLEVAEEFVIDRLRLKAFHTEVLNMQSGKNRKESAHRRAIIGFLMSHVASYRAIDPRLVLLSLLSDVHDTSILRSAIPLLASLFDDKSEESLWLSSLPDGQQALYVQALMGSLRVQSVSVLGEAGGEGWEFLLNLLDASKSSRFIARLRILSFKAMVGGVFSALEAHQQIEYIIALIQCIHALPTDDALDAVKVLEKLDIQPRVLIELIEHLSDPLETSVNRKRQRQDAADEDRPTQAVHELITFVDSRNWPSIPASAPLVASLMSILSALLAKRLIVKEGIDYLEQEVFGAILALVERITDAQEIQRAHVGIEVVIKVIRASTNPRTAQRALLVASELARLIPDAVLHNVMPIFTFMGASDFQRDDAYTFGVVEKTVSRIVPVMTQSLKEKAQNSLELYTKSLTFLSIFTDMAGRLPRHRTLPFFVHLVKSLGASDYLAPVCMLLVDRATTKAGRNKESVSTALELPANLVAAFDVSVKTQVLGEIVQELARLIGDLSKADKEAFLSQTISENDATDRPLRQVTYLLSFLSSILGQLRGKACSQALVQSAVRQLIVLAASTSQPVMATTDIPSNLHKTLASTMLLLSADNFLGVTAELLSDGSEQDIIMSLGVFAERLPLIKSEVRLRCTKVIAEILKRIGGLLAASGATVNAALEAVKSVIKTAIAQEDGALASVLPTVVGCIGKVKDSAVIVAALSLVELLVRRLAARTIPFIQSILDTSLNLIKSTKLAATATNQAFVTLSSVIETIPTFISSKQLNAILITTIDYRRVEETNSASLFTTLAKKIRTKSLFPVLIEAWKTVQEKGGDNEMKGFFEMLRLTLKNAAREDLPSMLKPVFAFFLDVFDLRHRLQLKGVDTRVVNDVEESAIGSFLELVTKLNEPTFKPLFIRLYDWAVIDLAEGKNADDGRLTERKIVLLHVMMGLLTKFKNLLSPYMGILFPHIQELLPAFASGSVRSEPLWTLLLNVLGKSFEVDSGAFWTDALEIELLPQLVAQVPLFLPIAPSPQSPRPISSCLANLAGSTTAENVLRRLNTAVCLATRSDDPKVRLAALDALSAIWDAQAEEMVGLVPETVSEFLAELLEDESKDVEIAARGVLAKIEKVTGSLKEYLE
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.  Involved in ribosome biosynthesis (By similarity).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 10.
What is the protein family that this protein belongs to?
Belongs to the HEATR1/UTP10 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ACCA_ACTP7
Sequence: MSQEYLDFELPIAELEAKIESLRAVSEQDGKIDLDDEIKRLQKKSEELTKKTFANLDAWQVSRMARHPNRPYTLDYIEHIFTEFDELAGDRAFADDKAIVGGIARLDGRPVMVIGHQKGRTTKEKVRRNFGMPAPEGYRKALRLMEMADRFNMPIITFIDTPGAYPGIGAEERGQAEAIARNLREMAQLKVPVICTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSAEKASTAAEVMGLTAQRLKELNLIDSIVAEPLGGAHRDVAQMAENLKQQILADLQDLAPLSTEDLLDRRYQRLMSYGYV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEBB_PROMS
Sequence: MLIQDTIFYRPDWRWHNFLKYLTNNLSKYNCLEKTIPSEYSYKDSTYGSKKSKKNVNLSTWGVTHKKRIKFARAVCINSPNYSVLNFLIIPNTIYNVPFFGVDFVSLPNSYLLVLDFQPSLKIQNQYNNDLLEKLIKLKNHCHSSLPLAEKMSADVARFFSPGVIWSKLPKEERSDFLITNQLYTSFKEYLDLYLEILFESKEVNIELQKELTNGQINYLNYRRDNDPARPMLSSLFGQEFTESLIEEVLFTT
What is the function of this protein?
Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin.
What are the official names of this protein?
Phycoerythrobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: BIVM_HUMAN
Sequence: MPNVAETERSNDSGNGEHKSERKSPEENLQGAVKSFCTSASGAPLGPKGDGHYPWSCPVTHTREKIYAICSDYAFLNQATSIYKTPNPSRSPCLPDSTSLSAGNNSSRYIGIPTSTSEIIYNEENSLENLSNSLGKLPLAWEIDKSEFDGVTTNSKHKSGNAKKQVSKRKTSDKKGRYQKECPQHSPLEDIKQRKVLDLRRWYCISRPQYKTSCGISSLISCWNFLYSTMGAGNLPPITQEEALHILGFQPPFEDIRFGPFTGNTTLMRWFRQINDHFHVKGCSYVLYKPHGKNKTAGETASGALSKLTRGLKDESLAYIYHCQNHYFCPIGFEATPVKANKAFSRGPLSPQEVEYWILIGESSRKHPAIHCKKWADIVTDLNTQNPEYLDIRHLERGLQYRKTKKVGGNLHCIIAFQRLNWQRFGLWNFPFGTIRQESQPPTHAQGIAKSESEDNISKKQHGRLGRSFSASFHQDSAWKKMSSIHERRNSGYQGYSDYDGND
What are the official names of this protein?
Basic immunoglobulin-like variable motif-containing protein.
What is the protein family that this protein belongs to?
Belongs to the BIVM family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CAS2_ECOLI
Sequence: MSMLVVVTENVPPRLRGRLAIWLLEVRAGVYVGDVSAKIREMIWEQIAGLAEEGNVVMAWATNTETGFEFQTFGLNRRTPVDLDGLRLVSFLPV
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids) (PubMed:21255106, PubMed:24920831, PubMed:24793649).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  The Cas1-Cas2 complex is involved in CRISPR adaptation, the first stage of CRISPR immunity, being required for the addition/removal of CRISPR spacers at the leader end of the CRISPR locus (PubMed:24920831, PubMed:25707795, PubMed:24793649).  The Cas1-Cas2 complex introduces staggered nicks into both strands of the CRISPR array near the leader repeat and joins the 5'-ends of the repeat strands with the 3'-ends of the new spacer sequence (PubMed:24920831).  Spacer DNA integration requires supercoiled target DNA and 3'-OH ends on the inserted (spacer) DNA and probably initiates with a nucleophilic attack of the C 3'-OH end of the protospacer on the minus strand of the first repeat sequence (PubMed:25707795).  Expression of Cas1-Cas2 in a strain lacking both genes permits spacer acquisition (PubMed:24793649, PubMed:24920831).  Cas2 not seen to bind DNA alone; the Cas1-Cas2 complex preferentially binds CRISPR-locus DNA (PubMed:24793649).  Highest binding is seen to a dual forked DNA complex with 3'-overhangs and a protospacer-adjacent motif-complement specifically positioned (PubMed:26478180).  The protospacer DNA lies across a flat surface extending from 1 Cas1 dimer, across the Cas2 dimer and contacting the other Cas1 dimer; the 23 bp-long ds section of the DNA is bracketed by 1 Tyr-22 from each of the Cas1 dimers (PubMed:26478180, PubMed:26503043).  Cas1 cuts within the 3'-overhang, to generate a 33-nucleotide DNA that is probably incorporated into the CRISPR leader by a cut-and-paste mechanism (PubMed:26478180).  This subunit's probable nuclease activity is not required for spacer acquisition (PubMed:24793649).
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family. E.coli-subtype subfamily.
Protein: MNME_AZOSB
Sequence: MASKAPRPPEAIAAIATAPGRGGIGVVRVSGAGLTGFAQQLCGREPQPRLATLARFRDADGATIDEGILLYFPAPASFTGEDVLELQGHGGPVVMQMLLARCLALGARLAEPGEFTRRAFLNGKLDLAQAEAVADLIEASTAAAARSALRSLSGQFSEEVLRIRDALIDLRMLVEATIDFPEEEVEFLDKGRALPRLAAIRTQLDALLDRARQGALLRTGMNVVLVGRPNVGKSSLLNQLAGEDRAIVTDVAGTTRDALREAIQIEGIPLHVIDTAGLRQTSDVVERIGIERTWREVERADVVLRVIDSEGAEEDALEAELAARCPSAAARITVVNKIDLLGLAPERTETAGAVRLRLSARSGDGVDLLRTELLRAAGWHAHGEDVVLARERHLLALREALDHLAAAEAAASALELFAEELRLAQEALAGITGEFSADDLLGEIFSRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GET3_ASPFC
Sequence: MSSTAVVHGDDLMEPTLQSILSQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYSNLSAMEIDPNGSIQDLLASGDSQGDDPLAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNIDELLQKMESLRETISEVNTQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYGIDTHAIVVNQLLFPKEGSGCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEKFSEMLVHPYVPPQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase get3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: RS5_FRATO
Sequence: MSNEVKKNEELIEKLVSVKRHSKTVKGGRIMSFAALTVVGDGKGRIGVGRGKSREVPAAIQKAMENAKKNMVSVNLNNDTLWYPVMSNHGASKVFMQPASAGTGIIAGGAMRSVFEAVGVHNVLAKTYGSTNPANVVRATIAGLAKIKSPDEIAEKRGLSVEEIQG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: Y1274_METB6
Sequence: MIREPFRYRETFAAILADTPAHADAAKRGMIAARQVLECYIARDPFFASTFFPYEPETDETLICHMANAAAHAGVGPMATVAGAIAAAGINAMMDAGATFGVIDNGGDIALVSDRDVRVGVHAGSAPVSDRIAFIVPPQEQHSYGICTSSATVGPSISFGMADAVTIFARDPLDADAWATAVCNRIRPDDHRVLETIDPSRVDGVYAIMGESVVSWGKVPPVVPARVDEQLIAAGDRL
What are the official names of this protein?
UPF0280 protein Mboo_1274.
What is the protein family that this protein belongs to?
Belongs to the UPF0280 family.
Protein: SYH_ELUMP
Sequence: MTKLVRGFRDIFAPESNNFAELEACARRVFTLAGGTEVRIPTLELKELFIKSTGDTTDIVQKEMYAFEDAGGRVLAMRPEGTPGTVRAYIENNFAQTAPVQKLFYIGNMFRAERPQAGRYREFEQIGMEYIGNPSPAADAEIILMIKDIVTSFGVKNYGVKINSLGCQECRPAYKQELINYLKKDFDTLCEKCKDRLEKNPLRVLDCKIDGARFKENAPKQKLCAACENHFNEVKTFLQGRIDYIIDPSLVRGLDYYTRTVFEFQAGDSAQNAIAGGGRYDSLVKSMGGADMPAVGFAMGVERTIAARGETKDNKQNKIFVVSLDKNCNAKAFEIMSLLRSAGVICDGGLFDKNLKAQMKQADRTKSSFALLLGADEFEKGVVTMRDLSSGEQQEIKFNDILNKVGKIRL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMEL_MOUSE
Sequence: MGVQRRSFLPVLVLSALLAVGALEGSRNQDWLGVPRQLVTKTWNRQLYPEWTEVQGSNCWRGGQVSLRVINDGPTLVGANASFSIALHFPGSQKVLPDGQVIWANNTIINGSQVWGGQPVYPQEPDDACVFPDGGPCPSGPKPPKRSFVYVWKTWGKYWQVLGGPVSRLSIATGHAKLGTHTMEVTVYHRRGSQSYVPLAHASSTFTITDQVPFSVSVSQLQALDGETKHFLRNHPLIFALQLHDPSGYLAEADLSYTWDFGDGTGTLISRALDVTHTYLESGSVTAQVVLQAAIPLVSCGSSPVPGTTDGYMPTAEAPGTTSRQGTTTKVVGTTPGQMPTTQPSGTTVVQMPTTEVTATTSEQMLTSAVIDTTLAEVSTTEGTGTTPTRPSGTTVAQATTTEGPDASPLLPTQSSTGSISPLLDDTDTIMLVKRQVPLDCVLYRYGSFSLALDIVQGIESAEILQAVPFSEGDAFELTVSCQGGLPKEACMDISSPGCQPPAQRLCQSVPPSPDCQLVLHQVLKGGSGTYCLNVSLADANSLAVASTQLVVPGQDGGLGQAPLLVGILLVLVAVVLASLIHRHRLKKQGSVSQMPHGSTHWLRLPPVFRARGLGENSPLLSGQQV
What is the function of this protein?
Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation.  The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape.  In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation.  May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway.
What are the official names of this protein?
Melanocyte protein PMEL, Melanocyte protein Pmel 17, Premelanosome protein, Silver locus protein.
What is the protein family that this protein belongs to?
Belongs to the PMEL/NMB family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus. Melanosome. Endosome, multivesicular body. Note=Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes (By similarity). SUBCELLULAR LOCATION: [M-alpha]: Secreted.
Protein: IL2_BUBCA
Sequence: MYKIQLLSCIALTLALVANGAPTSSSTGNTMKEVKSLLLDLQLLLEKVKNPENLKLSRMHTFNFYVPKVNATELKHLKCLLEELKLLEEVLNLAPSKNLNPREIKDSMDNIKRIVLELQGSETGFTCEYDDATVKAVEFLNKWITFCQSIYSTMT
What is the function of this protein?
Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance.  Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG).  Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3.  In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5.  This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways.  Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well.  Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production.  Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance.  Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
What are the official names of this protein?
Interleukin-2, IL-2, T-cell growth factor, TCGF.
What is the protein family that this protein belongs to?
Belongs to the IL-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: DIUX_DIPPU
Sequence: GLDLGLSRGFSGSQAAKHLMGLAAANYAGGP
What is the function of this protein?
Regulation of fluid secretion.  Stimulates primary urine secretion by Malpighian tubules and causes a dose-dependent stimulation of cAMP levels in the tubules.  Has a nonselective effect on Na(+)/K(+) ion transport.  In vitro, primarily elevates intracellular Ca(2+).  Has synergistic effects with the larger diuretic hormone DH(46) which co-occurs with it.
What are the official names of this protein?
Diuretic hormone class 2, DH(31), Diuretic hormone class II, Diuretic peptide, DP.
What is the protein family that this protein belongs to?
Belongs to the diuretic hormone class 2 family.
What are the subcellular locations of this protein?
Secreted.