PharMolix/UniProtQA huggingface dataset:
Protein: TGT_STRS7
Sequence: MTNYPITYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEIGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQAILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAADLVGMDFPGYSIGGLAVGESHAEMNAVLDFTTPLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSEGRLVVKNAKFAEDFTPLDHNCDCYTCQHYTRAYLRHLLKADETFGMRLTSYHNLYFLVNLMKQVRQAIMDDNLLEFRQDFLERYGYNSSSRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PANC_CAMC5
Sequence: MLILKTVKQLQEFVASAGDEIGFVPTMGALHDGHMSLIKKCVSENAVSIVSTFVNPTQFLPGEDLEKYPKKEESDIKICELCGVSAMFIPDAKEMYFDDEPCIIAPKKYSSILEGKSRPGHFDGVLRVLVKLFNLTRAKRVYMGKKDAQQLVIVQNMVKTLFLNLQVVPCEIVRESDGLALSSRNAYLSEEDKCNALRLSRALINASNLIKGGELDTSEIKTGMLKTLEPLTVDYVAIVDRDFNQISKVELGNTIILVAANVGKTRLIDNIWV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBSD_EDWI9
Sequence: MKKGTVLNSELSALISRLGHTDSVTVGDAGLPVPDGIQRIDLALTHGIPRFMQVIETMTAEMQVERAVLAQEMVEANPDIHRQLVTWLQRLAQTQGNAIHIDYVSHGQFKALSGESKAIVRSGECSPYANVLLYAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WHIB_BPMT4
Sequence: MHMHMGGDPSAICAQTDPELWFPDKGQSTRDAKRMCMRCPLLDECRALALRDPHLVGVWGGLSAQERRRIRKGASA
What is the function of this protein?
A dominant-negative regulator of endogenous whiB2 expression.  Low level expression in liquid culture in M. smegmatis leads to elongated and highly branched cells, with multiple nucleoids, similar to the effects seen in deletion experiments for whiB2 in M. smegmatis, as well as loss of acid-fastness.  High level expression is lethal.  Represses expression of endogenous whiB2.  The apo-form binds to the whiB2 promoter found in M. tuberculosis.  M. smegmatis cells expressing this protein will not grow on plates.  Low level expression in M. smegmatis leads to superinfection exclusion, possibly via modification to the cell wall.
What are the official names of this protein?
Probable transcriptional regulator WhiBTM4.
What is the protein family that this protein belongs to?
Belongs to the WhiB family.
What are the subcellular locations of this protein?
Host cytoplasm.
Protein: LPXK_SALSV
Sequence: MIARIWSGESPLWRLLLPLSWLYGLVSGAIRLSYKLGFKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEKLQQRGVRVGVVSRGYGGKAAAYPLLLTPETTTAKAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHNVQIIITDDGLQHYRLARDIEIVVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLTPGLAVNLRTGARCDVAQLSNIVAMAGIGHPPRFFATLEACGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWWFLPVDARLSGEQPDKLLQHITSLVR
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: MURD_PROMP
Sequence: MPIKNNSKKEGKINFVIGLGRSGFWAAKYLRSIGKRVIVWESKENKELLERKKILEKLDISVCLNKQFLFDEFYKFLRQIESIVVSPAIPFDHKTIIKLKERGIVVIGEINIAWESLKNINWIGITGTNGKTTVTHLLSHILRENNLFAPFAGNIGTPLCEIAYSTKSKNIDWIVAELSSFQIEIATHCIKPKIGIWTTFTPDHLDRHKTLDNYFKIKNSLLKQSEFRIYNYDDQYLKENFKSLLNGIWITTNPNVSDSDHCDYWINNENFIVERREKLLSLKNFKLKGNHNTQNLLLAVAAARKIGLSTERIKNALLSYEQLPHRMETIFQRDELEIINDSKATNFDSSVAGINAIKGSPIIISGGRLKNGDSIEWVKIINKKAKAVFLFGESSQTLKKLILEGGFKNDILTFNDLSEVINYAYSYIKNNQSETLLFSPSCSSFDQFRDYEQRGDIFKKLIYEKFNIKFIAH
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_ACTSZ
Sequence: MARVKRGVIARARHKKVLKAAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNSLSYSKFINGLKKASVEIDRKILADIAVFDKVAFTALVEKAKSVL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: YDZE_BACSU
Sequence: MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWILLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS
What are the official names of this protein?
Putative permease-like protein YdzE.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUTL_AGRFC
Sequence: MAIKQLSETLINQIAAGEVIERPSSATKELVENAIDAGATRIEIATAGGGKGLVRITDNGSGMSPADLELAVRRHCTSKISTTLDDIRTLGFRGEALPSIGSVAKLTITSRQQGAEQGSVISVTGGKVSDVRPAASNAGTIVEVRDLFFATPARLKFLKTERAEAAAITEVVKRMAIAFPHIRFVLSGTDRSTLEIPSTGDDHLARMAQILGAEFKDNAIEIDAGREDVTLTGFAGVPTFNRGNSSHQYVFVNGRPVQDKLLLSAIRGAYAETVPHGRYPVAVLSITLDPAFVDVNVHPAKSDVRFRDPGLIRGLIVGAIRQALTRDGDRAATTGASQMMNAFRPGYSPSGLRPSPSATWSAATSPSRPLAVSGDMQFAEAAQSRFSDITMPTARAEPREAYEASQSPSPEPVLYPLGAARAQLHENYIIAQTENGLVIVDQHAAHERLVFEEMRNALHSRRPPSQVLLIPEIIDLPEEDCDRLMDHAAGFDALGLVIERFGPGAIAVRETPAMLGEVNVQGLVRQLADEIAEWDAASTLANKLEYVAATMACHGSVRSGRRMRPEEMNALLRQMENTPGSGQCNHGRPTYIELKLSDIERLFGRS
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: LYZL6_HUMAN
Sequence: MTKALLIYLVSSFLALNQASLISRCDLAQVLQLEDLDGFEGYSLSDWLCLAFVESKFNISKINENADGSFDYGLFQINSHYWCNDYKSYSENLCHVDCQDLLNPNLLAGIHCAKRIVSGARGMNNWVEWRLHCSGRPLFYWLTGCRLR
What is the function of this protein?
May be involved sperm-egg plasma membrane adhesion and fusion during fertilization (PubMed:28182716).  Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus (PubMed:28182716, PubMed:24013621).  Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH (PubMed:28182716).  Bacteriolytic activity is pH-dependent, with a maximum at around pH 5. 6 (PubMed:28182716).
What are the official names of this protein?
Lysozyme-like protein 6.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted. Cell surface. Cell projection, cilium, flagellum. Note=Detected on the postacrosomal membrane of mature spermatozoa (PubMed:28182716).
Protein: HSCB_BUCAP
Sequence: MDYFALFNLPKKYIIDKFLLSKNFYKLQLKFHPDLFIHHSESKKRIVLQKSIEINKGYKILQDSLNRAIHLLFLNGFKISKEKVLSEDNSFLKKYFFLYEELDFLLKNNCDEVQIDIFFKKIRNKIDNYEKIIEIKFNEKKWDDIIKLITKLLFFKKIQTRLKQS
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA (By similarity).
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: TORD_ECO7I
Sequence: MTTLTAQQIACVYAWLAQLFSRELDDEQLTQIASAQMAEWFSLMKSEPPLTAAVNELENRIAALTVRDDARLELAADFCGLFLMTDKQAALPYASAYKQDEQEIKRLLVEAGMVTSGNFNEPADHLAIYLELLSHLHFSLGEGSVPARRIDSLRQKTLTALWEWLPEFAARCRQYDSFGFYAALSQLLLVLVECDHQNR
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLYE_ASPFN
Sequence: MYQKLLLVPLLLTSALASPHDASSHQKFHQLNERAAFPIPASKGSQTFKEPYYVKGTYDGGMKTFGRGVKCTGQKEGGDKDAVFIVADGGILRNAIIGADQIEGVHCEGSCTIENVWWQEVCEDALTFKGTGTGVHKVIGGGAQGADDKVIQHNSGGSAIIQDFTVQNFGKLYRSCGNCKKQFKRTVQISGVKASNGKTLVGINPNLGDSATIDGCASSVKEICVEYEGTDNNGKEPKKAHSGPSNTCKFKEPLASC
What is the function of this protein?
Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase.  Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.  Favors pectate, the anion, over pectin, the methyl ester (By similarity).
What are the official names of this protein?
Probable pectate lyase E.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: GAG_HV1SE
Sequence: MGARASVLTGGKLDAWEKIRLRPGGRKSYKIKHLVWASRELERFALNPDLLETAEGCQQIMRQLQPSLQTGTEEIKSLYNAVATLYCVHQRIEVKDTKEALEEVEKIQKKSQEKIQQAAMDKGNSNQVSQNYPIVQNAQGQMVHQAITPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNLMLNTVGGHQAAMQMLKDTINEEAAEWDRMHPQQAGPFPPGQIREPRGSDIAGTTSSLQEQITWMTGNPPIPVGEIYKRWIILGLNKIVRMYSPVSILDIRQGPKEPFRDYVDRFFKCLRAEQASQDVKGWMTDTLLVQNANPDCKTILRALGQGASLEEMMTACQGVGGPSHKARVLAEAMSQASGAAAAIMMQRSNFKGPRRTIKCFNCGKEGHLARNCRAPRKKGCWKCGKEGHQMKDCTERQANFLGKIWPSNKGRPGNFLQNRTEPTAPPAESLGFGEEIAPSPKQEMKEKELYPSLKSLFGSDP
What is the function of this protein?
Plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Gag polyprotein]: Host cell membrane; Lipid-anchor. Host endosome, host multivesicular body. Note=These locations are probably linked to virus assembly sites. The main location is the cell membrane, but under some circumstances, late endosomal compartments can serve as productive sites for virion assembly. SUBCELLULAR LOCATION: [Matrix protein p17]: Virion membrane; Lipid-anchor. Host nucleus. Host cytoplasm. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.
Protein: SOX2_DANRE
Sequence: MYNMMETELKPPAPQPNTGGTGNTNSSGNNQKNSPDRIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNGMGAGVGVGAGLGAGVNQRMDSYAHMNGWTNGGYGMMQEQLGYPQHPSLNAHNTAQMQPMHRYDMSALQYNSMTNSQTYMNGSPTYSMSYSQQSTPGMTLGSMGSVVKSESSSSPPVVTSSSHSRAGQCQTGDLRDMISMYLPGAEVQDQSAQSRLHMSQHYQSAPVPGTTINGTIPLSHM
What is the function of this protein?
Transcriptional activator.  May function as a switch in neuronal development (By similarity).  Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
What are the official names of this protein?
Transcription factor Sox-2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MASZ2_PSESM
Sequence: MTDFVKCQRLKVAVKLQRFVDEEVLPGTGLEPEAFWKGFDALVHDLAPVNRELLAERERLQGQLDKWHKAHPGPITDMPAYRAFLHSIGYLQPVPEHVAATTANVDLEISEQAGPQLVVPASNARYALNAANARWGSLYDALYGTDVISTSNGAEIRAGYNPLRGAKVIAFARELLDTSAPLANGSHSDANRYRIEDGELRITLADGSQTLLQHPEKYVGFTGEPDQPQAILLKNHGLHIEIQFDPQHPVGKTDAAGIKDLLLESALSTIVDCEDSVAAVDADDKVLVYRNWLGLMKGDLTETLDKGGKAITRSLNPDRVYHAAAGGELTLRGRSLLLIRNVGHLMSNPAIVDQDDKEIPEGILDGVITSLIGLHDLTRHGNSRAGSIYIVKPKMHGAAEVAFADQLFSRIEDVLHLPRNTLKMGIMDEERRTSVNLKACINAASARVAFINTGFLDRTGDEIHSAMQAGPVLRKGEMKNTPWIKAYERNNVQVGLACGLRGRAQIGKGMWAMPDRMADMLEQKIAHPKSGATTAWVPSPTAATLHAWHYHHVDVRQVQEQLEQQSLVDVSDQWLDDLLTIPVVGKPEWTREQILEELENNTQGLLGYVVRWVEQGIGCSKVPDIHNVGLMEDRATLRISSQHMANWLLHDIAGKEDIQNVLERMAKVVDKQNAGDSHYRPMTRDFKNSAAFKAACALVFKGTEQPSGYTEPLLHESRLAFKDAH
What is the function of this protein?
Involved in the glycolate utilization.  Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
What are the official names of this protein?
Malate synthase G 2.
What is the protein family that this protein belongs to?
Belongs to the malate synthase family. GlcB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STRU2_BPPAJ
Sequence: MAYDTSAFPLGSKDPRVLYNNAENMDVAMNSVEQERWMDRGPQRPPLPRWTYWGMEQNYNRFISNSAWELPPLVYVDGSPLTVERSSQVIERDGNLYSVKLPASFPVELSGTWSADEPLLVFRSDQSLRQELAEQNGGTLVGWKRTQLSASIDTIQQLADSIPIRVWEFAELVSDKPSPDPATWNWTPAFQAMVDTAESYMQSSGAKQITCYAGPGTFLIDSIVWRSGVHMYFGGAELKAHPDSIDGNSLINATLKLSDIGFYGPGIVNGDKDSFDPEHRQHGIHCVAKKVKVKDLFIENIGSSSVFSLGDGVIFRPTIPEGDFQCEDCEVSGCTFSNIERQCITVESGFNIRILSNGFYNSTYAALDIENAGYTMGDVDGVIFQGNYIDGCLYGVTAVTYQPVDAQRNIVCGGNIYKNVMDAYHFRGCSNVKVGYGDIAEVSRYGAYIYSDGATTVSNIEISDFTTSGGTYGVYAQTTSGGSFNRIKLSTLKITGTSTSPITVQSTSGLRIEEVDVLINTGAGVVIQNCASPIIRNLKMVGAVTLSVPAVSFIGTTTNPRVGGLDIAGFTVGVSVTTSATTTIHSLSNNVFAGVATPWSVNPGNYIKGQFSGTFTMNAAASMNVNSVGMNVTSSVVRLIPTNAAAATLQAGSKMAWVVNSASSNNVSFRVQTADGTAAAGTETFAFVIENL
What is the function of this protein?
Structural protein.
What are the official names of this protein?
Structural protein 2, ORF23 protein.
What are the subcellular locations of this protein?
Virion.
Protein: SYI_PSEPK
Sequence: MTDYKATLNLPDTAFPMKAGLPQREPQILQRWDSIGLYQKLREIGKDRPKFVLHDGPPYANGKIHIGHALNKILKDMIVRSKTLAGFDAPYVPGWDCHGLPIEHKVEVTHGKHLSADRTRELCREYAAEQIEGQKTEFIRLGVLGDWDNPYKTMNFANEAGEIRALAEMVKQGFVFKGLKPVNWCFDCGSALAEAEVEYADKKSQTIDVAFPVADEAKLAAAFGLASLAKPAAIVIWTTTPWTIPANQALNIHPEFKYALVDTGERLLVLAEELVESCLKRYNLEGSVVASAQGSALELINFRHPFYDRLSPIYLADYVELGAGTGVVHSSPAYGEDDFVTCKRYGMVNDDILTPVQSNGVYVDSLPFFGGQFIWKANPAIVEKLSEVGALMHTETISHSYMHCWRHKTPLIYRATAQWFVGMDKQPSTGEPLRERALKAIEDTKFVPAWGQARLHAMIANRPDWCISRQRNWGVPIPFFLHKQTGDLHPRTVELMEEVAKRVEQQGIEAWFKLDAAELLGAEADQYDKIADTLDVWFDSGTTHWHVLRGSHDIGHATGPRADLYLEGSDQHRGWFHSSLLTGCAIDNHAPYRELLTHGFTVDENGRKMSKSLGNTIEPEKVNNTLGADILRLWVSATDYSGEMAVSEQILQRSADAYRRIRNTARFLLSNLSGFDPARDLLAPEDMLALDRWAVDRTLLLQRELEEHYSEYRFWNVYSKVHNFCVQELGGFYLDIIKDRQYTTGANSVARRSCQTALYHISEALVRWIAPILAFTADEIWQYLPGERNESVMLNGWYQGLSELPEGTELDRAYWDRVMAVKASVNKELENQRTAKVIGGNLQAEVTLYADEGLSADLGKLGDELRFVLITSAASVVPFAQAPAEAVATEVEGLKLQVVKSGHTKCGRCWHFRADVGSHPEHPEICGRCVDNLTGSGEVRHYA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTRK3_PIG
Sequence: MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEAKLNSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVVTCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVHYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKITHVEYYQEGEVSEGCLLFNKPTHYNNGNYTLNRQEPLGTANQTINGHFLKEPFPESTDNFVSFYEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHDQPWHHHTLITGRRAGHSVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKVKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQICSGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
What is the function of this protein?
Receptor tyrosine kinase involved in nervous system and probably heart development.  Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
What are the official names of this protein?
NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SCS1_MESMA
Sequence: MNRLTTIILMLIVINVIMDDISESKVAAGIVCKVCKIICGMQGKKVNICKAPIKCKCKKG
What is the function of this protein?
Inhibits potassium channels.
What are the official names of this protein?
Putative potassium channel blocker TXKS1, BmTXKS1.
What are the subcellular locations of this protein?
Secreted.
Protein: COI1A_ORYSJ
Sequence: MGGEVPEPRRLNRALSFDDWVPDEALHLVMGHVEDPRDREAASRVCRRWHRIDALTRKHVTVAFCYAARPARLRERFPRLESLSLKGKPRAAMYGLIPDDWGAYAAPWIDELAAPLECLKALHLRRMTVTDADIAALVRARGHMLQELKLDKCIGFSTDALRLVARSCRSLRTLFLEECHITDKGGEWLHELAVNNSVLVTLNFYMTELKVAPADLELLAKNCKSLISLKMSECDLSDLISFFQTANALQDFAGGAFYEVGELTKYEKVKFPPRLCFLGLTYMGTNEMPVIFPFSMKLKKLDLQYTFLTTEDHCQIIAKCPNLLILEVRNVIGDRGLEVVGDTCKKLRRLRIERGDDDPGLQEEQGGVSQLGLTAVAVGCRELEYIAAYVSDITNGALESIGTFCKNLYDFRLVLLDRERQVTDLPLDNGVCALLRNCTKLRRFALYLRPGGLSDDGLSYIGQYSGNIQYMLLGNVGESDHGLIRFAVGCTNLQKLELRSCCFSERALSLAVLQMPSLRYIWVQGYRASQTGLDLLLMARPFWNIEFTPPSPESFNHMTEDGEPCVDSHAQVLAYYSLAGRRSDCPQWVIPLHPA
What is the function of this protein?
Involved in jasmonate (JA) signaling.  Required for jasmonate signaling in plant defense responses (PubMed:22529386).  Can complement Arabidopsis coi1-1 mutant and restore jasmonate signaling (PubMed:23320078).  Required for JA-regulated defense responses to infestation by the leaffolder Cnaphalocrocis medinalis (PubMed:22558386, PubMed:24003150).  May act on an initial response of jasmonate-regulated gene expression toward drought tolerance as part of a BHLH148-TIFY11D/JAZ12-COI1A complex (PubMed:21332845).  Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including TIFY/JAZ family (By similarity).
What are the official names of this protein?
Coronatine-insensitive protein homolog 1a, OsCOI1a.
Protein: RL9_BURPS
Sequence: MQIILLEKVANLGNLGDIVKVKDGYARNFLIPNRKARRATKDAIAEFEVRRAELEKVAAEKLAAAQAVGEKLNGQTFEITQKSGVDGRLFGSVTNGDVAELLKKAGYEIEKAQVRMPEGPLKMIGEHGVQVALHTDVVVDVTVNVIGDHA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: ILVD_SHEPW
Sequence: MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAISNSFTQFVPGHVHLKDMGQLVAGAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLSDKLIKLDLVDAMVAGADDRVSDADSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRIMDLTTRYYRDDDQSALPRNIANFNAFENAMTLDIAMGGSSNTVLHLLAAAIEAEVDFSMDDIDRLSRLVPHLCKVAPSTPKYHMEDVHRAGGVMGILGELDRAGLLHNDAYHVAGSNLAEVLAKYDIAQSKDEAVHKFFSAGPAGIPTTKAFSQDCRWDSVDIDREAGCIRTREFAFSQEGGLAVLSGNVALDGCIVKTAGVEVENHTFIGSARVYESQDDAVAGILGGEVVEGDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGTKCALITDGRFSGGTSGLSIGHVSPEAAAGGTIALVNTGDRIEIDIPARSIKLAISDVELAARRTAMEALGKDAWKPVGRVRQVSMALKAYALLATSADKGAVRDTSKLG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: PRIO_GORGO
Sequence: MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP, PrP27-30, PrP33-35C.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: YGEE_SCHPO
Sequence: MLLSNKIKHSIFQFFVFPFYYFLLIITEIGFSSCIQYSGLSAYFPIKCTLSLLSSPIRRVQVISDSLNVKGKRLLLVVTAHSRLRVNADIGGLISNIGCGKRPTILSTVNTGSNTSREGKS
What are the official names of this protein?
Putative uncharacterized protein C1347.14c.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.