PharMolix/UniProtQA huggingface dataset:
Protein: CHP1_HUMAN
Sequence: MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTIQEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH
What is the function of this protein?
Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription.  Involved in the constitutive exocytic membrane traffic.  Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane.  Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity.  Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH.  Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane.  Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange.  Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity.  May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus.  Associates to the ribosomal gene promoter.  Acts as a negative regulator of the calcineurin/NFAT signaling pathway.  Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity.  Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B.  Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
What are the official names of this protein?
Calcineurin B homologous protein 1, Calcineurin B-like protein, Calcium-binding protein CHP, Calcium-binding protein p22, EF-hand calcium-binding domain-containing protein p22.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family. CHP subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Endomembrane system. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell membrane. Membrane; Lipid- anchor. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1 at the reticulum endoplasmic and plasma membrane. Colocalizes with STK17B at the plasma membrane.
Protein: CNIH1_HUMAN
Sequence: MAFTFAAFCYMLALLLTAALIFFAIWHIIAFDELKTDYKNPIDQCNTLNPLVLPEYLIHAFFCVMFLCAAEWLTLGLNMPLLAYHIWRYMSRPVMSGPGLYDPTTIMNADILAYCQKEGWCKLAFYLLAFFYYLYGMIYVLVSS
What is the function of this protein?
Involved in the selective transport and maturation of TGF-alpha family proteins.
What are the official names of this protein?
Protein cornichon homolog 1, CNIH-1, Cornichon family AMPA receptor auxiliary protein 1, Protein cornichon homolog, T-cell growth-associated molecule 77, TGAM77.
What is the protein family that this protein belongs to?
Belongs to the cornichon family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane. Note=Located primarily in the ER; may cycle between the ER and the Golgi apparatus.
Protein: RL6_CLOB8
Sequence: MSRVGRLPIAIPADVTVTVTPDNLVTVKGPKGELVKTMHKDISIAVENNEVIVTRHSEQKDHRALHGLTRALINNMVIGVKQGYQKTLDLVGVGYRAQLQGKKLVMNLGYSHPVEIEPIDGITFETPAATRVIVSGIDKEKVGFAAADIRKWRVPEPYKGKGIKYENEVIRRKEGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: AT2B3_RAT
Sequence: MGDMANSSIEFHPKPQQQREVPHVGGFGCTLAELRSLMELRGAEALQKIQEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIPPKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKYGDLLPADGVLIQGNDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKGKQQDGAMESSQTKAKKQDGAVAMEMQPLKSAEGGEMEEREKKKANVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVDGRVWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPEKEGALPRQVGNKTECALLGFILDLKRDFQPVREQIPEDQLYKVYTFNSVRKSMSTVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVKKIIEPMACDGLRTICIAYRDFSAIQEPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDSTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLWCLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEIDHAERELRRGQILWFRGLNRIQTQMEVVSTFKRSGSFQGAVRRRSSVLSQLHDVTNLSTPTHIRVVKAFRSSLYEGLEKPESKSCIHNFMATPEFLINDYTHNIPLIDDTDVDENEERLRAPPPPPPNQNNNAIDSGIYLTTHATKSATSSAFSSRPGSPLHSMETSL
What is the function of this protein?
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals.  Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25014339, PubMed:9880546).  May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (PubMed:25014339, PubMed:9880546).
What are the official names of this protein?
Plasma membrane calcium-transporting ATPase 3, PMCA3, Plasma membrane calcium ATPase isoform 3, Plasma membrane calcium pump isoform 3.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Presynaptic cell membrane; Multi-pass membrane protein. Note=Localized at parallel fiber terminals.
Protein: YACG_PASMU
Sequence: MTDDIFSVPCPICQKQVEWSDKSPFRPFCCKRCQLIDLGEWAAEEKAIPCESADFAMNDEQEDWRAH
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: RL3_STRS7
Sequence: MTKGILGKKVGMTQIFTESGEFIPVTVIEATPNVVLQVKTVETDGYEAIQVGFDDKREVLSNKPAKGHVAKANTAPKRFIREFKNIEGLEVGAEITVDIFAAGDVVDVTGTSKGKGFQGVIKRHGQSRGPMAHGSRYHRRPGSMGPVAPNRVFKNKHLAGRMGGNRVTIQNLEIVQVIPEKNVILIKGNVPGAKKSLITIKSAVKAAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: MET3_ASPFU
Sequence: MANPPHGGVLKDLLARDAPRHDELEMEAEKLPAIVLTERQLCDLELIMNGGFSPLEGFMNQKDYDSVCENVRLADGNLFSMPITLDVSQAVIDEGKLKPGSRVTLRDFRDDRNLAILTIDDIYRPDKAKEAKLVFGGDEEHPAIKYLYNKVQEFYVGGKIEAINKLNHYDYVALRYTPAELRVHFDKLGWNRVVAFQTRNPMHRAHRELTVRAARARQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPRYPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGKNSKGQEFYGPYDAQHAVEKYREELGIEVVEFQQVTYLPDTDEYKPKDEVPPGVKTLDISGTELRNRLRTGAPIPEWFSYPEVVKILRESSPPRHTQGFTIFLTGYMNSGKDAIARALQVTLNQQGGRSVSLLLGDTVRHELSSELGFSREDRHTNIQRIAFVAGELTRAGAAVIASPIAPYEESRNAARDAVTQAGGNFFLVHVATPLEYCEKTDKRGIYAKARRGEIKGFTGVDDPYETPSKADLTVDVSKQTVRSIVHEIILMLETEGFFDRS
What is the function of this protein?
Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP.  Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
What are the official names of this protein?
Sulfate adenylyltransferase, ATP-sulfurylase, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the APS kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPI_HALRO
Sequence: TKKDGEEKVA
What is the function of this protein?
Strongly inhibits trypsin and plasma enzyme(s) activity.
What are the official names of this protein?
Serine proteinase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the serpin family.
Protein: NCAP_SFTS
Sequence: MSEWSRIAVEFGEQQLNLTELEDFARELAYEGLDPALIIKKLKETGGDDWVKDTKFIIVFALTRGNKIVKASGKMSNSGSKRLMALQEKYGLVERAETRLSITPVRVAQSLPTWTCAAAAALKEYLPVGPAVMNLKVENYPPEMMCMAFGSLIPTAGVSEATTKTLMEAYSLWQDAFTKTINVKMRGASKTEVYNSFRDPLHAAVNSVFFPNDVRVKWLKAKGILGPDGVPSRAAEVAAAAYRNL
What is the function of this protein?
Encapsidates the genomic RNA, protecting it from nucleases.  Displays high affinity for single-stranded nucleic acid.  The encapsidated genomic RNA is termed the nucleocapsid (NC) or ribonucleoprotein (By similarity).  The ribonucleoprotein has a non-helical structure (By similarity).  Serves as template for viral transcription and replication.  After replication, the nucleocapsid is recruited to the host Golgi apparatus by glycoprotein Gn for packaging into virus particles (By similarity).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the phlebovirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus. Host endoplasmic reticulum-Golgi intermediate compartment. Host Golgi apparatus.
Protein: S2548_MOUSE
Sequence: MGSFQLEDFVAGWIGGVASVIVGYPLDTVKTRLQAGVGYANTFNCIRMVYKRERVFGFFKGMSFPLASIAIYNSVVFGVFSNTQRFLSKYRCGELEAGPGRSLSDLLLASMLTGVVSVGLGGPVELIKIRLQMQTQPFREASHGLKSRAVAAYQGPVHCIATIVQMEGLTGLYRGASAMLLRDIPGYCFYFIPYVFLSEWITPEACTGPSPYAAWLAGGIAGAISWGTATPMDVVKSRIQADGVYLNKYRGVVDCISQSYQQEGFKVFFRGITVNAVRGFPMSAAMFLGYELSLKALRGEHTVRSE
What are the official names of this protein?
Solute carrier family 25 member 48.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS12_AZOPC
Sequence: MPTIQQLVRKGRATFLKKGKAPALDSCPQKRGVCVRVYTTTPKKPNSAMRKVARVRLTNSKEVNVYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGALDTAGVSGRMQRRSKYGAKFPKTGTGKTKAVPTKNKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: TRI68_HUMAN
Sequence: MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGED
What is the function of this protein?
Functions as a ubiquitin E3 ligase.  Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM68, RING finger protein 137, RING-type E3 ubiquitin transferase TRIM68, SSA protein SS-56, SS-56, Tripartite motif-containing protein 68.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.
Protein: IP5P4_ARATH
Sequence: MGDGNLKKSKLSWPKTLVKKWLNIKSKSEDFHADDLDRGEGGGDWRNNVIEREEACSVRKSKTETRSKRNSGRARRNKLDVDPPLDHLRVFTATWNVAGKSPPSYLNLDDWLHTSPPSDIYVLGFQEIVPLNAGNVLGTEDNGPARKWVSLIRRTLNSLPGGSCQTPSPVPHPVAELDSDFEGDSAAGANSLFYHRSRSMRMDASASSLPQQFDRRFSVCDRFMLGDTPDDFYDQSFRYCSSEDEPADSPCHDHYSPVSRTGSFVADDRDKGRDKSKYCLVASKQMVGIFLTVWVKSDLRDSVNNLKVSCVGRGLMGYLGNKGSISISMSVHQTSFCFVCSHLTSGQKEGDELRRNSDVLEILRKTRFPRVNNAGDDKSPQMISEHDRVIWLGDLNYRIALSYRSAKALVEMRDWRALLEKDQLRIEQRKGCVFEGWKEGTIYFPPTYKYSNNSDIYAGDDRLPKAKRRTPAWCDRILWHGSGISQLSYVRGESRFSDHRPVYSLFSVEIESAYRNRIKKSSSYTSSRIEVEELLPQRYGYSELNPY
What are the official names of this protein?
Type I inositol polyphosphate 5-phosphatase 4, At5PTase4.
What is the protein family that this protein belongs to?
Belongs to the inositol polyphosphate 5-phosphatase family.
Protein: Y1648_BACAA
Sequence: MKVIAVTGYKPFELGIFKNDHPGVECIKKALRRKLTAFVEGGLEWVIISGQLGVELWTAEVVFEIQVEYPDLKLAVFTPFLEQEEGWKEDNREYYEFILSQADHVDSITKRKYESPEQFKLKNQIFIEKSDALLAVYDEEKPGSPKYIVEAAKKKGEIENYHSYFILFSDLQDIIEEEQWNNAE
What are the official names of this protein?
UPF0398 protein BAA_1648.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: PYRD_ALBFT
Sequence: MALIPYALARPFLFSLDPETAHELTVRALALTQGTALQLAYGTSRVNDPITLAGLTFPNRVGLAAGLDKNARCIDGLGAMGFGFVEVGTVTPLAQPGNPRPRLFRLPQAQALINRFGFNNEGLASFMANVKNSTFYRQRQNPNLARKPLPLLLGLNIGKNAATPIERATEDYLTCLDGVYPYADYVAVNISSPNTRNLRSLQSDEALDSLLGAIAHRRQALVAQHGKQTPIFVKIAPDLDASQVDVIAASLRRHGMDGVIATNTTLSRDAVKGLAHADETGGLSGAPVLAMSNRVIGQLRAALGPGFPIIGVGGVMSADDAVSKIRAGADLVQIYTGLIYHGPKLVKQAAALIKTSC
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HIS1_MYCLE
Sequence: MLRVAVPNKGALSEPATEILAEAGYRRRTDPKDLTVVDPVNRVEFFFLRPKDIAIYVGSGDLDFGITGRDLVHDSDASVCERLALGFGSSSFRYAGPAGRDWTTSDLAGKRIATAYSNLVRKDLVAKGIEATVIRLDGAVEISVQLGVADVIADVVGSGRTLSLHDLVAFGEPLCDSEAVLIERGDRGSLDHHETVAARDQLVARVQGVVFGQQYLMLDYDCPRSVLDKATLITSGLESPTIAPLAEPGWVAIRALVPRRDINGIMDELAAIGAKAILASDIRFCRF
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_CHLTA
Sequence: MSSRDFSNDLFSINIEENAGCVVSAKVQANPLVTQKCHKEALKTVKKNVVLPGFRKGKAPDNIVESRYSTQVEQELRRLFLRASFEALSQMCDRKPLSPKAVRSSAIDTCNPVNGGSVSFLYEAFPVIPSLPWEQLSLPDPEPVKEISEEDLENGLKNVAYFFATKTPVTRPSQEGDFISLSLYVSKRGDENSTPVAIFENKYFKISEEDMTDSFKARFLNVSTGHRVEEEIGSEDIQSFLNGDLLTFTVNAVIEISSPEMDDEKARQLQAESLEDLKKKLRIQLENQAKEAQHQKRFSDAEDALAQLIDFDLPESLLQEREELLSREKLLNARLVKYCSDSELEEQKQALLEEAKADARKAVKLLFLTQKVFSEKGLSISREELQYMMDVCSRERFGGYPPKDISNEMIQELVLVARDRLTYRKAIEAISSEKKDLEVVPS
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: TOR2X_HUMAN
Sequence: MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHLAGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRVHHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGSSWVVYGTNYRKAIFIFIRWLLKLGHHGRAPPRRSGALPPAPAAPRPALRAQRAGPAGPGAKG
What is the function of this protein?
Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis.  Salusins may also be potent hypotensive peptides.
What are the official names of this protein?
Prosalusin, Torsin family 2 member A, Torsin-2A.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. Torsin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: HIKES_HUMAN
Sequence: MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYESINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSMAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNPLFWKT
What is the function of this protein?
Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus.  HSP70 proteins import is required to protect cells from heat shock damages.  Does not translocate ADP-bound HSP70 proteins into the nucleus.
What are the official names of this protein?
Protein Hikeshi.
What is the protein family that this protein belongs to?
Belongs to the OPI10 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Nucleus.
Protein: TPRG1_MOUSE
Sequence: MSTIGSFDGFQPVSLKQEEEDQPSENDHLSTKEGNSGKDPGSRRISRQQSITKATLYPNPYRQPYVSRKYFVTRPGAIETAVEDLKGHIAQTSGETVQGFWLLTEIDHWNNEKEKILLLTDKTLLICKYDFIMLSCVQVQQVPLNAICCICLGKFVFPGMSLDKRPGDGLRIFWGSTEGWSLLSRWNPWSTEVPYATFTEHPMKQTSEKFLEICKLSEFTSKLVPAIENAHKNSAGSGSGKELVVLTQPILIETYTGLMSFIGNRNKLGYSLARGSIGF
What are the official names of this protein?
Tumor protein p63-regulated gene 1 protein, Protein FAM79B.
What is the protein family that this protein belongs to?
Belongs to the TPRG1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GME74_PESMI
Sequence: MVQLKAEIDAGPLDNSISIFSLIENGLRQKPDAPAVICLHESADALDHLIVPSNPRERERGPADGECLMLSYRQLHHTAVKLAVGFRAKGVAPGSTLLMLVPNGGHYALLLWACILARLTFISVDPAEVLDDLKSQRIASILQETRPEVVVIPSVIEAKAMDGILGATSITELLKISLKKVQEPGWERMTKLVSDGIANPLDMDALVEEARCDDPDRLYSIMFTSGTSERPKGCPLRVGGAAHMVRSWSWLINQINSSYALQQAHNSRGIAPAQTVQTWAEGGAVVMTGRGFDVDDMLDAIRLNYASFVVLTPAMAHALAAHLETHQIDMSSVKTVQVGGDAVTKNVLVKCNSLFPHADVCINHGMTEGGACFEWSFLDIAPSDVPFFGQICPVGKTARGAAVRIWDTEREEIAERGRPGQLHLSSESIIRHYLHGESAGSFYQQGGQRWFITGDIAMMTDEGTVYILGRSKDTIVSDGHLVMPFVIESCLEDLTGSQASVIAIPHPVYGQVPYAVLQTLKQVDDHAIQDQVVRLLGTDYQLAGINSLEALGMTTVPVNDTRKIIKSQIKEAVMRYIDGK
What is the function of this protein?
Acyl--CoA ligase; part of the gene cluster that mediates the biosynthesis of dibenzodioxocinones such as pestalotiollide B, a novel class of inhibitors against cholesterol ester transfer protein (CEPT) (PubMed:31474098).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS pks8/GME11356.  Pks8/GME11356 lacks a thioesterase (TE) domain, which is important to the cyclizing of the third ring of atrochrysone carboxylic acid, and the esterase GME11355 might play the role of TE and catalyzes the cyclization reaction of the C ring.  The lactamase-like protein GME11357 (or other beta-lactamases in Pestalotiopsis microspora) probably hydrolyzes the thioester bond between the ACP of pks8/GME11356 and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrates to form endocrocin anthrone.  Endocrocin anthrone is further converted to emodin via the endocrocin intermediate.  Emodin is then oxidized by several enzymes such as the Baeyer-Villiger oxidase GME11358, the oxidoreductase GME11367, the short chain dehydrogenase/reductase GME11373, as well as by other oxidoreductases from the cluster, to modify the A and C rings and open the B ring, and finally yield monodictyphenone.  The prenyltransferase GME11375 may catalyze the addition reaction between the C5 side chains and the carbon bone of dibenzodioxocinones.  The remaining biochemical reactions to the final product dibenzodioxocinones should be methylation catalyzed by methyltransferase GME11366 and reduction and lactonization reaction catalyzed by a series of oxidordeuctases (Probable).
What are the official names of this protein?
Acyl--CoA ligase GME11374, Dibenzodioxocinones biosynthesis cluster protein GME11374.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: FAR5_ASCSU
Sequence: SGKPTFIRF
What are the official names of this protein?
FMRFamide-like neuropeptide AF5.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MAUF_PARDE
Sequence: MVSVEDLHGLSAGQASVPDCKLFPQSPSAATRIAVLLAAALAGAAGGVALASAAGPQPLWAVLGAAAVAGGLLSTWSPCGYSSISLLRPDGRGLRAVAGWLPTFAMHGAGYGLGALMLGGLLGGIGLIAGFSGFGSTALLVLGLVGLAYGAHQLDFLRVPYPQRRAQVPHDARQRFPKWVIGGLYGLSLGLDYLTYVQTPLLYMMTLAAVFTGNIAHAIAIVALFNLGRFLPVAVNALPIPDYRVQAWLARHQENAALADGAILTALGAGFTVLALI
What are the official names of this protein?
Methylamine utilization protein MauF.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MHPB_MYCS2
Sequence: MPLALCCMSHSPLLNLPGPSAELLDQITDAIADARKFVEQFDPELVVTFSPDHYNGFFYRLMPPFCIGTAAAGVGDYGTYQGPLPVDADIANACAESLWESGVDIAISTAMDVDHGTVQPLQELFGDATARPVVPIFINSVATPLGPLSRSRALGAAVGTFLATLDKRVLIVGSGGLSHDPPVPTLATAPPAALDRIVHGAPMTPEQRMARQEAVIKAAHDFAHGQSPLRSLNPDWDRSLLEIFDEGRLSDLDGWTNTFITGEGGNSAHEIRTWVAAFAALAAHGEYQTGNHFYRAAPELIAGFAIRTAVPST
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.