PharMolix/UniProtQA huggingface dataset:
Protein: LEU1_BACHK
Sequence: MKQILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIHRSVTLGKSLFPTVQFSAEDATRTARDFLAEAIEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSITLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: SELO_RHOPB
Sequence: MAVHFPFDNSYAALPEGFFARVAPTPVATPRLIKLNRPLARELGLDPDRLDSPEGAEILAGKRIPEGADPIAMAYAGHQFGNFVPQLGDGRAILLGEVIDQNGVRRDIQLKGSGPTPYSRRGDGRAALGPVLREYIVSEAMAALDIPTTRSLAAVITGETVARETLLPGAVLTRIATSHIRVGTFQFFAARRNQDAVKALADHVIARHYPNAINTKQPYLTLLQEVIRRQAELVARWLLVGFIHGVMNTDNCSVAGETIDYGPCAFMDGYDPTKVFSSIDHTGRYAYGNQPRIALWNLTRLAECLVPLISDDQDAAIADAEAALGQFSEQFGQAYHAGLRAKLGLFTAQDGDRELIGDLLGAMIEQAADFTLTFRGLSDLAGNAETDSVRNLFAEPAAFDGWLGRWRQRTAAEPQDAATRRAAMQAVNPAFIPRNHRIQAVIEAAVERDDFAPFEELLAVLAHPYRDQPGFAGYAQPPQPHEQVLQTFCGT
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: MZT1A_ARATH
Sequence: MNQEAAETARESLELVFRMSNILETGLDRHTLSVLIALCDIGLNPEALATLVKELRRDSATTTTTVD
What is the function of this protein?
Required for gamma-tubulin complex recruitment to the microtubule organizing centers (MTOCs) (By similarity).  During mitosis, modulates gamma-tubulin complex localization, spindle stability and chromosomal segregation.  Necessary for gametophyte development and embryogenesis.
What are the official names of this protein?
Mitotic-spindle organizing protein 1A, GCP3-interacting protein 2, AtGIP2, Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1A, AtGIP1A.
What is the protein family that this protein belongs to?
Belongs to the MOZART1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, phragmoplast. Nucleus envelope. Note=Reorganized from the nucleus to the prospindle and the preprophase band in late G2. After nuclear envelope breakdown, localized on spindle and phragmoplast microtubules (MTs) and on the reforming nuclear envelope of daughter cells. Present in mitotic microtubule arrays. In interphase cortical arrays, gamma-tubulin complexes are preferentially recruited to existing microtubules, from which new microtubules are efficiently nucleated.
Protein: FPG_BACLD
Sequence: MPELPEVETVRRTLAGLVRGKTIDAVDVRWTKIIKRPEEPEEFARLLAGQTIQSIGRRGKFLLFHLDDCVMVSHLRMEGKYGLHQNDEPLDKHVHVIFRFTDGSELRYRDVRKFGTMHLFKPGEELTELPLRQLGPEPFSSEFTADYLRERLKKTNRSVKTALLDQRTVVGLGNIYVDEALFRAGIHPEATANKLTKKQTVLLHKEIIQTLKEAVEAGGSTVRSYINSQGEIGMFQLKLFVYGRKDEPCKKCGSPIEKTVVGGRGTHFCIKCQKK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: LEPA_SOLUE
Sequence: MDREFIRNFSIIAHIDHGKSTLADRLLEVTGALSQREMMEQVLDSMDLERERGITIKAHAVRLNYRADDGKLYQLNLIDTPGHVDFSYEVSRSLQACEGALLVVDASQGVEAQTLANTYLALHHNLEIIPVINKIDLPAAEPERIREQIETVVGIDARDAVLCSAKQGVGIHDILEAIVHLVPPPKGSPDAPLRALIFDSWFDSYRGVIILMRIIDGRMKLGQKIKLMANGQVFEVEGLGYQAPKATACSELQAGEVGFLYANIKTVGDAKIGDTITEVENPATEPLPGFEEIKPMVFAGLYPVESHEHGLLRDALEKLRLNDSAFNFEPENSAALGFGFRCGFLGLLHLEIVQERLEREFNIDLITTAPGVRYRITDTSGNLVEVDNPTKFPDPSYIETIEEPIIDASVITREDFLGGILALLEEKRGTQKKFEHIGAGRVMLTYELPLNEIVLDFYDRLKSASKGYASLDYHLSGYRESPMVKLDVLVAGEPVDALSIIVHKDFAFERGKALISRLRKLIPKQMFEVALQAAIGNKIVARETISAMRKNVIAKCYGGDISRKRKLLEKQKEGKKRMKRVGRVEIPQEAFLSVLKVSQSSDDD
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CHLB_RIPO1
Sequence: MKLAYWMYAGPAHIGTLRIASSFKNVHAIMHAPLGDDYFNVMRSMLERERDFTPVTASIVDRNVLARGSQEKVVDNIVRKDGEENPDLIVLTPTCTSSILQEDLANFVDRAQMDAKGDVMLADVNHYRYNELQAADRTLHQIVKFYLEKAQKKGELPQRKTEKPSVNIIGISTLGFHNQHDCTELKRLMADLGIEVNEVIPEGASVHNLKNLPKAWFNLVPYRELGLATAGYLEEQFGMSYVDITPMGVVETARCIRKIQQLINAQGAEVDYEEFIKEQTLYVSQAAWFSRSIDCQNLTGKKAVVFGDNTHAAAITKILAREMGIHVVLAGTYCKYDADWFREQVSEYCDEVLISDDNAAIGDAIARLEPSAIFGTQMERHVGKRLDIPCGVIASPIHIQNFPIGYKPFCGYEGTNQITDLIYNSFTLGMEDHLLEIFGGHDTKEVITKGISADSDLNWNKEAQAELNKVPGFVRGKVKRNTEKFARERGFSVITLEVMYAAKEAVGA
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
Protein: RNT2B_MOUSE
Sequence: MAPAEARGALPGWISVLGWGLALCSLCGAGPLWSGSHEWKKLILTQHWPPTVCKEVNSCQDSLDYWTIHGLWPDRAEDCNQSWHFNLDEIKDLLRDMKIYWPDVIHRSSNRSQFWKHEWVKHGTCAAQVDALNSEKKYFGKSLDLYKQIDLNSVLQKFGIKPSINYYQLADFKDALTRIYGVVPKIQCLMPEQGESVQTVGQIELCFTKEDLHLRNCTEPGEQLSSRQEAWLAMEASTHGMMVCEDGPIFYPPPTKTQH
What is the function of this protein?
Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8.  Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides.  In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8.  Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria.  Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
What are the official names of this protein?
Ribonuclease T2-B, Ribonuclease 6-B.
What is the protein family that this protein belongs to?
Belongs to the RNase T2 family.
What are the subcellular locations of this protein?
Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Mitochondrion intermembrane space.
Protein: MURI_LIMFE
Sequence: MDNRPIGVMDSGLGGLSVVRVIQQKLPNEEVIFVGDQGHFPYGTKDQAEVRQLALSIGAFLLKHDVKMMVVACNTATAAALPALQAALPIPVIGVIEPGARAALAQDKKGPIGVIATTATTTAGAYPATIERLAPGTPVIAKATQPMVEIVEHGQTGTAKAQEVVSEQLMTFKEHPVKTLIMGCTHFPFLAPEISKAVGPTVALVDPAKETVATAKSWLEQHQAMGNHAHPNYHLYSTGNLPDLRAGVNKWLLSGHFDLGTAQIEEGD
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: THII_METMA
Sequence: MQGAFTDNTNNTGSEKETNVVIVRYGELALKSPGVRNWYEKILMKNIAAMLDSKNIPYSLMRREWGRIFIETTDPRAAGAAADVFGVVSTSSALITKPELDSAAETCAFLGKKIIQEGESFAIRARRSGNHSFSSADIGRACGDAVWNMLESEGKHPKVNLGSPDREIFVEMRQNLAYVYLETVKGVGGLPLGTQGKMVVLMSGGLDSPVAAWLMMKRGVMIIPVYCNTSPYAENAAKERAYDCIRQLQTWASGHQFTTYEIPHGPNLRSFIEMCDRKNTCLLCKRMMYREAYEIMKKEGASGIITGSSLGQVASQTAANMHAEIYQLAIPIYHPLIAFDKSEIIDIARKIGTYDISTRSAGSCTAVPERPEVKANYDLIVLEEKRLDIENMVSEALKAAKVLKL
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_HAEIG
Sequence: MARVTVQDAVEKIGNRFDLILTAARRARQLQLNQSVPLVPEDNDKPTVIALREIEKGLINQDIMDAQEFQKMAKVQETEEAAVALITE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PYC_SCHPO
Sequence: MTSKYDALLHNQSTNTNPFSKLQDRSSLLGEKFTKVLVANRSEIAIRVFRTAHELSMHTVAIYSYEDRLSMHRQKADESYPIGKVGQYSPVGAYLAIDEIVSIAKRTGANLVHPGYGFLSENAEFARKVNEAGMQFVGPSPEVIDSLGDKTKARAIAIRCGVPVVPGTPGPVEHYEEAEAFVKEYGLPVIIKAAMGGGGRGMRVVRSADTLKESFERARSEALASFGDGTVFIERFLDKPKHIEIQLMADKAGNVIHLHERDCSVQRRHQKVVEIAPAKDLDPKIRQALYDDAIKIAKEVKYCNAGTAEFLLDQKGRHYFIEINPRIQVEHTITEEITGVDIVSAQLHVAAGFTLPEIGLTQDKISTRGFAIQCRVTTEDPNNGFAPDIGKIEVYRSAGGNGVRLDGANGFAGSVITPHYDSMLVKCTCHDATYEYTRRKMIRSLIEFRVRGVKTNIPFVLRLLMHDTFIQGNCWTTFIDDTPELFQLYRSRNRAQKLLAYLGDLAVNGSSIKGQNGEPALKSEIVMPVLLDSTGNQIDVSHPSEKGWRKLLLDNGPAAFAKAVRNHKRGLIMDTTWRDAHQSLLATRVRTIDLVNIAPYTSHALASAYSLEMWGGATFDVSMRFLHECPWDRLRRLRKLVPNIPFQMLLRGANGLCYSSLPDNVIYFFCEQAKKNGIDIFRVFDALNDVNNLSLGIDAAKRAGGVVEATMCYSGDMLNPKKKYNLDYYVNLVDKMVEMGIHILGIKDMAGVMKPKAARLLISAIREKHPELPIHVHTHDSAGTAVASMAAALEAGADVVDVATDSMSGLTSQPSFGAVLASVDGTDKQLEFDNNQLREIDSYWAQMRLLYSPFESEIKGTDSDVYNHEIPGGQLTNLKFQATSLGLGTQWAETKKAYIEANKLLGDIIKVTPTSKVVGDLAQFMVQNKLSAEDVENRATTLDFPASVLDFFQGLMGQPYGGFPEPLRTNVLKGRRQPLTDRPGKFLPAADFDAIRKLLSEKFGVSSDCDIAAYTQFPGVFEEYRQFVDRYGDLTTVPTKFFLSRPEMNEEMHVEIDQGKTLIVKFVALGPLNPRTGQREVYFELNGENRHVTVEDKKAAIETVTRPRADPGNPGHVAAPMSGTIVEIRVKEGAKVKKGDIIAVLSAMKMEIVISAPHSGVLKSLAVVQGDSVNGGDLCAVLEHE
What is the function of this protein?
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
What are the official names of this protein?
Pyruvate carboxylase, Pyruvic carboxylase, PCB.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSTT_ECO57
Sequence: MTTQRSPGLFRRLAHGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPILVLMLVMASIANHQHGQKTNIRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGDISPPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLGFALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAQLLVVLVGCMLLVALVVNPLLVWWKIRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVNTLGIPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGISNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQAEDDRLANSALRN
What is the function of this protein?
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
What are the official names of this protein?
Serine/threonine transporter SstT, Na(+)/serine-threonine symporter.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSP20_NIPBR
Sequence: MALWPVDRFERMMMEDPMRAMDRFGRMGDMDHWMSRRMMPYWRDADHSMLHVGNQKEVINDDKKFAVSLDVKHFKPNELKVQLDDRDLTVEGMQEVKTEHGYIKKQFVHRWSLPEDCDLDAVHTELDNHGHLSIEAPEDGPSQKFQSSAHSSSAEEEEVGDIEPVNKRILYK
What are the official names of this protein?
Heat shock protein homolog, HSP20.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: HIS6_ARTS2
Sequence: MAVAVRVIPCLDVDAGRVVKGINFEGLRDAGDPVELAHRYDNGGADELTFLDVTASSGNRETTFDVVRRTAEEVFIPLTVGGGVRGVAEVDKLLRYGADKASINTAAVARPDVIDEITRHFGSQVLVLSVDARRTRPGSEPTASGFEVTTHGGRQGTGIDAIEWAREAADRGVGEILLNSIDADGTKDGFDIELIRLVRAAVRVPIIASGGAGKPEHFPPAVAAGADAVLAASIFHFGPVDMISQVKTAIREAGFEVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_ACAM1
Sequence: MSESYKVISDNRQARFQYEILEVFEAGLALTGTEVKSIRAGKVNLRDGFAQIRNEEAFLLNVHVSPHTNAGQFFNHDPRRTRKLLMHRQEIRKLIGKTEQKGLTLVPLKLYLQRGWIKVTIGLARGKKLHDKRESIKKRQDKRDMERALKRGAE
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: EFM7_CRYNB
Sequence: MSQDPILTSKGSQEEEDFFGLDNFFPEPESPLPPPFSFASYDIPANIDFYVPDHRKSLILRLVGSHPLWGHHLWNTARTLSTYLLETPQITQSRHVLELGAGAGLPSIVCVLAGSSKVIVTDYSDEGLLDNLRFNVDVNLEGEEKERIAVDGHVWGQSVDPLLGHLPKGQKYDLLILSDLVFNHSQHDALIKTVEATLTSSSTQSYDPSNPSAPLTEPSILVFFTHHRPHLAHADMAFFPRLAESGNGWAYEKVVEEWAGAMFENDPGDKKVRGTVHGWRAWRVRDGEERGEKPSRISL
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.
What are the official names of this protein?
Protein N-terminal and lysine N-methyltransferase EFM7, Elongation factor methyltransferase 7.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRM1_VZVD
Sequence: MELDINRTLLVLLGQVYTYIFQVELLRRCDPRVACRFLYRLAANCLTVRYLLKLFLRGFNTQLKFGNTPTVCALHWALCYVKGEGERLFELLQHFKTRFVYGETKDSNCIKDYFVSAFNLKTCQYHHELSLTTYGGYVSSEIQFLHDIENFLKQLNYCYIITSSREALNTLETVTRFMTDTIGSGLIPPVELFDPAHPCAICFEELCITANQGETLHRRLLGCICDHVTKQVRVNVDVDDIIRCLPYIPDVPDIKRQSAVEALRTLQTKTVVNPMGAKNDTFDQTYEIASTMLDSYNVFKPAPRCMYAISELKFWLTSNSTEGPQRTLDVFVDNLDVLNEHEKHAELTAVTVELALFGKTPIHFDRAFSEELGSLDAIDSILVGNRSSSPDSQIEALIKACYAHHLSSPLMRHISNPSHDNEAALRQLLERVGCEDDLTKEASDSATASECDLNDDSSITFAVHGWENLLSKAKIDAAERKRVYLEHLSKRSLTSLGRCIREQRQELEKTLRVNVYGEALLQTFVSMQNGFGARNVFLAKVSQAGCIIDNRIQEAAFDAHRFIRNTLVRHTVDAAMLPALTHKFFELVNGPLFNHDEHRFAQPPNTALFFTVENVGLFPHLKEELAKFMGGVVGSNWLLSPFRGFYCFSGVEGVTFAQRLAWKYIRELVFATTLFTSVFHCGEVRLCRVDRLGKDPRGCTSQPKGIGSSHGPLDGIYLTYEETCPLVAIIQSGETGIDQNTVVIYDSDVFSLLYTLMQRLAPDSTDPAFS
What is the function of this protein?
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging.  Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm.  Once the complex reaches the host nucleus, it interacts with the capsid portal vertex.  This portal forms a ring in which genomic DNA is translocated into the capsid.  TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
What are the official names of this protein?
Tripartite terminase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae TRM1 protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.
Protein: GLYA_MYCPA
Sequence: MSAPLADIDPDIAGLLGQELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEYVDVVENIARDRAKALFDADFANVQPHSGAQANAAVLHALMTPGERLLGLDLANGGHLTHGMKLNFSGKLYDVGFYGVDPTTHLIDMDAVRAKALEFRPKVIIAGWSAYPRVLDFAAFASIADEVGAKLWVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGPRSGLILGKQEYAKSINSAVFPGQQGGPLMHVIAAKAVALKIAGTEEFADRQRRTLSGARILAERLSGADVAAAGVSVVSGGTDVHLVLVDLRNSELDGQAAEDLLHEIGITVNRNAVPNDPRPPMVTSGLRVGTPALATRGFGGAEFSEVADVIATALAGGRGADLAALRDRVTRLARDFPLYEGLEDWALVGR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_BURMA
Sequence: MNAEAKPGDWLGKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALAKTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRRSCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UB2D2_RAT
Sequence: MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  In vitro catalyzes 'Lys-48'-linked polyubiquitination.  Mediates the selective degradation of short-lived and abnormal proteins.  Functions in the E6/E6-AP-induced ubiquitination of p53/TP53.  Mediates autoubiquitination of STUB1 and TRAF6.  Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection.  Essential for viral activation of IRF3 (By similarity).  Mediates ubiquitination of PEX5.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 D2, (E3-independent) E2 ubiquitin-conjugating enzyme D2, E2 ubiquitin-conjugating enzyme D2, Ubiquitin carrier protein D2, Ubiquitin-conjugating enzyme E2(17)KB 2, Ubiquitin-conjugating enzyme E2-17 kDa 2, Ubiquitin-protein ligase D2.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
Protein: SYDP_PSYIN
Sequence: MNHTTQTQLFDFFERFKAHWQTQKKSLPQAIFEPQWISPCQIGEVENQLIFWSPIKREPALDMSNIEQALDIKLHPSIVDFFCSAYSAGLPAVYQDHPIELIQAWNDEDFNLLQENMLAHFMMQKRLKQPASMFIASCSDEMQIVSVLNATGEVQLETLGKGQEAILAENLADFLATLTPVIIE
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: PSTB_XANCP
Sequence: MHRIAVPAAKGAPTAQAPVKVAARNLDFYYDKYHALKGINIEIPEKRVTALIGPSGCGKSTLLRIFNRIYALYPKLEARGEVLLDGENILSPKYPMNRLRSKVGMVFQKPVPFPMTIFENVAYGIRHHEKLSKADMQNRVEHALRQGALWDEVKDKLGQSALGLSGGQQQRLCIARAVALRPDVLLLDEPTSALDPISTSRIEQLVEELKRDYTIVIVTHNMQQAARVSDYTAFMYLGDLIEHDRTETIFSQPSKQQTEDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FLIE_ECO24
Sequence: MSAIQGIEGVISLLQATAMSARAQDSLPQPTISFAGQLHAALDRISDTQTAARTQAEKFTLGEPGVALNDVMTDMQKASVSMQMGIQVRNKLVAAYQEVMSMQV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.