PharMolix/UniProtQA huggingface dataset:
Protein: QCR10_YEAST
Sequence: MAYTSHLSSKTGLHFGRLSLRSLTAYAPNLMLWGGASMLGLFVFTEGWPKFQDTLYKKIPLLGPTLEDHTPPEDKPN
What is the function of this protein?
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol.  In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable).  QCR10 has a role in CIII assembly and RIP1 stability (PubMed:8175712, PubMed:30598556, PubMed:30598554).
What are the official names of this protein?
Cytochrome b-c1 complex subunit 10, mitochondrial, Complex III subunit 10, Complex III subunit XI, Ubiquinol-cytochrome c oxidoreductase subunit 10, Ubiquinol-cytochrome c reductase 8.5 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the UQCR11/QCR10 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: YBEY_BORAP
Sequence: MSKSDLNLLVENIKFEHLSIFYDFILSVLNTLSISDFELSVILCDNVYIQKLNNKFRNKNEPTDVLSFNYNEVNEDLVDGINYKIQGDLIISFEYLKFSAQEFNVEIYEELQRVTIHGILHLMGYKHETNDFQKEGMLILQENILRKNKRVF
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_CAUSK
Sequence: MAKTPAKAPAAAAKPAAVKKPAAPKAAAAPKAAAVATPAAKKPAAPKAAPVSKVAGTREKPDTIRAGTGKLVQVIGAVVDVEFTGELPAILNALETVNIATGQRLVFEVAQHLGQNTVRAIAMDATEGLVRGQEVRDTGQSIRVPVGPGTLGRIMNVIGEPIDEQGPIKSDIFRTIHRDAPTFAEQTNTAEVLVTGIKVIDLMCPYTKGGKIGLFGGAGVGKTVTMQELINNIAKAYGGYSVLAGVGERTREGNDLYHEMIESNVNVDPKINGSTEGSRCALVYGQMNEPPGARARVALTGLSIAEYFRDEEGKDVLLFVDNIFRFTQAGAEVSALLGRIPSAVGYQPTLATEMGNLQERITSTNKGSITSVQAIYVPADDLTDPAPAASFAHLDATTVLSRDIAAQAIFPAVDPLDSTSRIMDPLIIGQEHYDVARSVQEVLQQYKSLKDIIAILGMDELSEEDKLTVARARKISRFLSQPFHVAEQFTNTPGAFVSLKDTIRSFKGIVDGEYDHLPEAAFYMVGPIEEAVAKAEKLAGEA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MIP_CHICK
Sequence: MRELRSSSFWRAILAEFLGSLLYTLLGLGASLRWAPGPHGVLGSALAFGLAQATLVQALGHVSGGHINPAITLAFLLASQLSLPRALGYLLAQLLGALAGAGVLYGVTPAAVRGTLGLSALHPSVGPGQGTVVELLLTAQFILCVFASFDDRHDGRPGSAALPVGFSLALGHLFGIPFTGAGMNPARSFAPAVITRNFTNHWVFWAGPLLGAALAALLYELALCPRARSMAERLAVLRGEPPAAAPPPEPPAEPLELKTQGL
What is the function of this protein?
Water channel.  May be responsible for regulating the osmolarity of the lens.  Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.
What are the official names of this protein?
Lens fiber major intrinsic protein, Aquaporin-0, AQP0, MIP26, MP26.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein: CYC_CANLF
Sequence: MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFSYTDANKNKGITWGEETLMEYLENPKKYIPGTKMIFAGIKKTGERADLIAYLKKATKE
What is the function of this protein?
Plays a role in apoptosis.  Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol.  Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: TRMN6_YERPA
Sequence: MGEQLKKQPVLRGGGFTFKQFFVAHDRCAMKVGTDGVLLGAWVPVLHARRVLDIGCGSGLIALMIAQRSLPQVQIDGVELEPAAAQQASSNVELSPWAERIHIHQQDIHQFAENHPHQYDLIVSNPPYFAPAIACRDEARDTARYTGSLTHDALLNCAEKLITEDGMFCVVLPHELGIEFARLAGQQGWFVRCQVDIRDRPGKPLHRMLLTLSRQAGETVYQHLALRQSEGVYSPEFCQLISDFYLNY
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECD_LEPBD
Sequence: MQNKKSHYIWLFLVIFVPALILYFNKVKLGLDLRGGTSVVLQAQGKIEADTMSKVRNIIERRVNSIGVAEPVIQLSGNDKLIVELAGIKDPQKAIELIGTTAKLEFRIKNKDGSYGPVLLEGSALKSAGVSRDQVGMPSVSFELNSQGANTFAKITRENIGKQLAIMLDNKEQSAPTINSEINGGSGIITGRFSMEEANNLANLLKSGALPVEIKIVENRTVGATLGVDSIKQTGIAGLIALGVISVFMIAIYKIPGIVADIALLINGVLVLGLLSGIGAALTLPGIAGFILTLGMAVDSNVITYERIKEELRLGESLHDAVERGYENAFPAIIDGNITTLLVAAVLFFLGTGPIKGFAVTLSLGVVATIITGVFVSKVILKLFIKTFNIKREQLFWKGALNED
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPD_BACC3
Sequence: MNNYLRKLVEGQHLTEEEMYKAGLLLLNENILESEIAAFLVLLKAKGETAEEIYGLVRALREKALPFSNHIQGAMDNCGTGGDGAQTFNISTTSAFVLAGADVKVAKHGNRAVSSKTGSADLLEELGVNISSTPNEIDYLLEHVGIAFLFAPAMHPALKRIMKIRKELNVPTIFNLIGPLTNPVNLETQFVGIYKRDMLLPVAQVLQKLGRKQALVVNGSGFLDEASLQGENHVVILKDNEIVETSIEPEKYGFSIVKNEEIRGGNSKENAKITLGVLSGEKSVYRDTVLFNAGLALFANGKAKTIEEGITLAAHSIDSGKALAKLNLLIAASNEKLERVN
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: MRAZ_THEP3
Sequence: MLMGQYEHTIDAKGRVIIPAKFRGELGDRFVLTKGLDNCLFVYSLEEWKNIEAKLKTLPLTKKDARAFTRFFLAGAVECEIDKQGRILIPANLREHAKIEKDVIFIGVSTRVEIWSKEVWEEYSNNTDVSFEEIAEHLDELNI
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MURC_AZOVD
Sequence: MVKSQDAIQAEIRRMRRIGCIHFVGIGGAGMCGIAEVLLNLGYEVSGSDLKASPVTARLESFGAKIFIGHRAENAASADVLVVSSAVNSSNPEVMTALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGSSRYLIAEADESDASFLHLQPMVAVVTNIDADHMDTYEGDFSRLKKTFVDFLHNLPFYGLAVLCVDDPVVREILPLVARPTITYGLGEDADIRAVDIRQAGMRTYFTVLRQERAPLEMSVNMPGVHNVLNALATIAIACDEGIDDTAIVQGLSGFQGVGRRFQVYGELQIEGGGVMLVDDYGHHPREVAAVLKAVRGGWPDRRLVMVYQPHRFTRTRDLYEDFVQILSDANVLLLMEVYPAGEEPIPGADSRSLCRSIRQRGQLDPIYVERGADIAPLLKPLLRPGDILLCQGAGDIGGLAPQLLRNPLFGGRPEAVAQRELP
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLND_ECO55
Sequence: MNTLPEQYANTALPTLPGQPQNPCVWPRDELTVGGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVRNSAITGIYSTTLRQLRHARRHLQQPLCNIPEARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSTELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: PTCRA_RAT
Sequence: MARTWLLLFLGLRCQALPSGIAGTPFPSLAPPVTLLVDGRRHTLVVCLVLDAAPPGLDSLVWFSGGNGSALDAFTYGPSPAPDGTWTSLGQLSLSSEELEAWEPLVCHTRPAAGGLNRSTHPLQLSGEEASTDRTCPQETLRGTQRQVLRLSVLRLLLFKLLLLDVFLTCSRLCVLAGQHLLPPPSSKQAPASTHQSWT
What is the function of this protein?
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.
What are the official names of this protein?
Pre T-cell antigen receptor alpha, pT-alpha, pTa, pT-alpha-TCR.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GSTA2_MOUSE
Sequence: MAGKPVLHYFNARGRMECIRWLLAAAGVEFEEKFIQSPEDLEKLKKDGNLMFDQVPMVEIDGMKLVQTRAILNYIATKYDLYGKDMKERALIDMYTEGILDLTEMIGQLVLCPPDQREAKTALAKDRTKNRYLPAFEKVLKSHGQDYLVGNRLTRVDVHLLELLLYVEELDASLLTPFPLLKAFKSRISSLPNVKKFLHPGSQRKPPLDAKQIEEARKVFKF
What is the function of this protein?
Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds.
What are the official names of this protein?
Glutathione S-transferase A2, GST class-alpha member 2, Glutathione S-transferase GT41A.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Alpha family.
Protein: PPOF_SOLLC
Sequence: MSSSTPNTLPLLSTNKSLSSPFTNNHSTFLSKPSQPFLHGRRCQSFKVSCNVGEHDKNLDAVDRRNVLLGLGGFYGAANLAPLASAAPIPPPDLKSCGVAHIDDKGTEVSYSCCPPVPDDIDSVPYYKFPPMTKLRIRPPAHAADEEYVAKYQLATSRMRELDKDPFDPLGFKQQANIHCAYCNGAYKIGGKELQVHFSWLFFPFHRWYLYFYERILGSLINDPTFALPYWNWDHPKGMRIPPMFDREGSSLYDEKRNQNHRNGTIIDLGHFGKDVRTPQLQIMTNNLTLMYRQMVTNAPCPSQFFGAPLGSDPEPGMGTIENIPHTPVHIWTGDSPRQGHGEDMGNFYSAGLDPLFYCHHANVDRMWNEWKLIGGKRRDLSNKDWLNSEFFFYDENRNPYRVKVRDCLDSKKMGFDYPPMPTPWRNFKPIRRSSSGKVNTASIAPVSKVFPLAKLDRAISFSLTRPASSRTTQEKNEQQEILTFNKMAYDDTKYVRFDVFLNVDKTVNAEELDKAEFAGSYTSLPHVHGNNDNHVKDVTFTLAITELLEDIGLEDEDTIAVTLVPKVGGEGVSIESVEIKLEDC
What is the function of this protein?
Catalyzes the oxidation of mono- and o-diphenols to o-diquinones.
What are the official names of this protein?
Polyphenol oxidase F, chloroplastic, PPO, Catechol oxidase.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid lumen.
Protein: DYR_HELVI
Sequence: MSQVKLNLIAAACDNMGIGVNGALPWRLKKEMAYFTTMTSKVSEPTKVNAVIMGRRTWDCIPDKYRPLQDRVNIVLTHNVDSVKENVPEGVMVFPGLDEAIKYIEGREDIESTWVIGGSSIYRAAMTHPNCGKIYLTEIQKSFDCDTFFPNIDKQQFHLVDEEQIPGEKQVEGNISYYFRVYKKL
What is the function of this protein?
Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
What are the official names of this protein?
Dihydrofolate reductase.
What is the protein family that this protein belongs to?
Belongs to the dihydrofolate reductase family.
Protein: AGALB_PENSI
Sequence: MLTSLSLTALALLPSANALVRKDGVGRLPALGWNSWNAFGCDVDSTKIMTAANEMVHLGLKDLGYEYVNIDDCWSVKNTRNSTTQRIIPDTQKFPDGISGVADQVHQLGLKIGIYSSAGETTCAGYPASLGYEKVDAEAFAEWGIDYLKYDNCGVPSNWTDQYSSCVPDGSNEPANGTCPGLSNPAPAGYDWTKSNTFTRYTMMRDALLGQTRTILYSLCDWGQADVNTWGNETGNSWRMSGDISANWARIAQIANENTFRMNYVGFWGHPDPDMLEVGNGDLTAAENRAHFALWAIMKSPLIIGTALDGISDANLAVLKNKYLIEFNQDPIIGRSAHPYKWGYNPDWTFDPAHPAEYWSGPSSTLKGTLVLMLNSENSTSTRTAVWKEIPELKGHNAYRVTDAWSGKDLGCVKKQYSASLASHDVAVLVVKEAC
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase B, Melibiase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PZP_HUMAN
Sequence: MRKDRLLHLCLVLLLILLSASDSNSTEPQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVSASLESGRENRSLFTDLVAEKDLFHCVSFTLPRISASSEVAFLSIQIKGPTQDFRKRNTVLVLNTQSLVFVQTDKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEPIQGSYRVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVPGLATVSLCRKLSRVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQITNTGFEMKLRVEARIREEGTDLEVTANRISEITNIVSKLKFVKVDSHFRQGIPFFAQVLLVDGKGVPIPNKLFFISVNDANYYSNATTNEQGLAQFSINTTSISVNKLFVRVFTVHPNLCFHYSWVAEDHQGAQHTANRVFSLSGSYIHLEPVAGTLPCGHTETITAHYTLNRQAMGELSELSFHYLIMAKGVIVRSGTHTLPVESGDMKGSFALSFPVESDVAPIARMFIFAILPDGEVVGDSEKFEIENCLANKVDLSFSPAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLMKPEAELSVSSVYNLLTVKDLTNFPDNVDQQEEEQGHCPRPFFIHNGAIYVPLSSNEADIYSFLKGMGLKVFTNSKIRKPKSCSVIPSVSAGAVGQGYYGAGLGVVERPYVPQLGTYNVIPLNNEQSSGPVPETVRSYFPETWIWELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEVFTLKATVLNYLPKCIRVSVQLKASPAFLASQNTKGEESYCICGNERQTLSWTVTPKTLGNVNFSVSAEAMQSLELCGNEVVEVPEIKRKDTVIKTLLVEAEGIEQEKTFSSMTCASGANVSEQLSLKLPSNVVKESARASFSVLGDILGSAMQNIQNLLQMPYGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAIKGGVEDEATLSAYVTIALLEIPLPVTNPIVRNALFCLESAWNVAKEGTHGSHVYTKALLAYAFSLLGKQNQNREILNSLDKEAVKEDNLVHWERPQRPKAPVGHLYQTQAPSAEVEMTSYVLLAYLTAQPAPTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRYGAATFTRTEKTAQVTVQDSQTFSTNFQVDNNNLLLLQQISLPELPGEYVITVTGERCVYLQTSMKYNILPEKEDSPFALKVQTVPQTCDGHKAHTSFQISLTISYTGNRPASNMVIVDVKMVSGFIPLKPTVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMVLQDIPVGDLKPAIVKVYDYYETDESVVAEYIAPCSTDTEHGNV
What is the function of this protein?
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.  This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases.  When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase.  The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced).  Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
What are the official names of this protein?
Pregnancy zone protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Protein: HIGA1_MYCTO
Sequence: MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLSTLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
What is the function of this protein?
Antitoxin component of an atypical, type II toxin-antitoxin chaperone (TAC) system.  Probably neutralizes the toxic effects of cognate toxin HigB1, which also requires SecB-like chaperone MT2006 (AC Q7D7P7).  Autorepresses its operon (higB1-higA1-MT2006).
What are the official names of this protein?
Antitoxin HigA1.
Protein: DCDB_CORGL
Sequence: MLLSDRDIRKSIDAGDLGIEPFDAELIQPSSVDVRMDRYFRVFNNSKYTHIDPKLNQDELTSLVEVEDGEGFVLHPGEFVLASTLEKFTLPAHLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGYITLELSNVANLPITLWPGMKVGQLALFQMSSPAETPYGSGKLGSKYQGQRGPTPSKAYLNFPNK
What is the function of this protein?
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
What are the official names of this protein?
dCTP deaminase, dUMP-forming, Bifunctional dCTP deaminase:dUTPase, DCD-DUT.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: TIG_OENOE
Sequence: MVDIIKTNATFKAGKGNKGTLSFEIPAKQISSGIDQAFNKQKDKINIPGFRKGHVSKELFLARFGEEALYEDALNAILPDIYDQAVNEADITVVGQPQIIPDDLKHGGPSKIHAEVTLAPTVELGDYKGVEVEKESDEVSDKELNAELERLQKGEAELVPAKEDQVSEKGDTVVIDFDGSVDGKQFDGGKAQNFSLSLGSGQFIPGFEDQLVGHKAGDDVDVKVTFPKDYQAKNLAGKEAVFAVTIHELKKLETPALDNEFAKDVDDSVLVLEELKAKTKEKLAKDKAEKNKDAFEDAAIQKVVDGAKINPEKLPEEMINDDVSRQMQTFFNNLAGQGVKPEMYFQIPNQPGAVKATNDRRRTNRVKTNLVLEEIARVEKINPSNEEIDKEIKSLASEYNIKESEVEKSVSAGMLSHDLKVQQAVELIVNSAQAVEKK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: TUB_HUMAN
Sequence: MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
What is the function of this protein?
Functions in signal transduction from heterotrimeric G protein-coupled receptors.  Binds to membranes containing phosphatidylinositol 4,5-bisphosphate.  Can bind DNA (in vitro).  May contribute to the regulation of transcription in the nucleus.  Could be involved in the hypothalamic regulation of body weight (By similarity).  Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
What are the official names of this protein?
Tubby protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TUB family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).
Protein: LYSC1_PIG
Sequence: KVYDRCEFARILKKSGMDGYRGVSLANWVCLAKWESDFNTKAINRNVGSTDYGIFQINSRYWCNDGKTPKAVNACHISCKVLLDDDLSQDIECAKRVVRDPQGIKAWVAWRTHCQNKDVSQYIRGCKL
What is the function of this protein?
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
What are the official names of this protein?
Lysozyme C-1, 1,4-beta-N-acetylmuramidase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 22 family.
What are the subcellular locations of this protein?
Secreted.
Protein: KPYK_ENCCU
Sequence: MRMVLTKIVCTIGPRTSSREKIKELIDAGMSIARLNFSHGSREAHLEVIRNIRDSRSGAGRHVSIALDTRGPEVRLRTPEMKDIKVEGGEVLRFSLLSSEKDIWIPGVDLKSLGVDNRVFIDDGAIELRVVNVEEDGFECEVLNSGMIKSNKSMNFPGTDIGDRALGDEDKNDIAFGLENGIDMVFASFVSCRADVEEIRRLVGSKVPVVSKIESCLGMRNLKEIALCSDGVMIARGDLGVEIGLENMFSAQKRILYEVKREGRPVICATQMMESMTLKNAPNRSEISDVGNAVLDGCDCVMLSAESAVGMFPVETVKFMRSICADAERYDMESRKGAGACGVSSYVDGVVICSGTESQIEKIYLSKPETPIIVISESLWILRRFSIYRGIIPVYGKGSEDAEATLRRLGLRGRFLAVGREDVRMVSV
What are the official names of this protein?
Pyruvate kinase, PK.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
Protein: MUTS_CHLP8
Sequence: MAKSAQGRKKEPTPMMRQYLEVKERYPEYVLLFRVGDFYETFLDDAVTVSAALNIVLTKRSNGSAGEIPLAGFPHHASEGYIAKLVTKGFKVAVCDQVEDPALAKGIVKREITDIVTPGITYSDKILDDRHNNYLCAVALFKRGREHLAGVAFVDVTTAEFRMTELPVAELKDFLQSLHPSEILISSRDKELRDSLAKSMNTLFTVLDEWMFSAEQASQVLENHFKTHSLKGFGIDGVEGGRIAAGAILQYLEEAKQGSLKYLVRIGLVESAETMTLDIQTRRNLEIISSMQDGSLNGSLLEVIDRTKNPMGARLLRRWLLHPLRKLEAVVQRHDAVEELLESDSMREESRQLLGGIIDLERALARIATSRAMPREVRLLGSSFALIPQLKAMLASCEAQRLRHLADRLDSLPELAETIERALDPEASGTLRDGGYIRAGYHEELDELRAISSGARDRLLEIQQAERSKTSISTLKVQYNKVFGYYIEVSRANSDKVPEYYEKKQTLVNAERYTIPALKEYEEKILTAEEKSQFLEHRLFQELCAAVAAEAASIQKTAAALAELDCLACFASCADEYRYCRPAMNEGTELSITGGRHPVLERILGADEPYVANDCRVGSDQQLLIITGPNMAGKSSYLRQAGLVVLLAQVGSFVPAESAEIGLVDRIFTRVGASDNLTSGESTFLVEMNEAASILNNATERSLLLLDEIGRGTSTFDGMSIAWSMCEFIHDRLRARTLFATHYHELAELESRFERIVNFNATVVETADTVIFLRKIVRGASDNSYGIEVAKMAGMPPEVIERAREILAGMERREVEVPTQREAPPRVVSQQISLFEEEESRLRKALSGIDINRLTPLDAMMELKRLQDIALGKSKA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: CBDB_BURCE
Sequence: MTSLESSYLDVVAFIFREARLLDDRSWDEWLECYDPEAVFWMPCWDDADTLVDDPRKHVSLIYYSDRMGLEDRVFRLRSERSGASTPEPRTTHNIANVEILERTERQIEARFNWHTMNYRYKLLDHYFGTSFYTLKVSSSGLSILNKKVVLKNDLIHQVIDVYHV
What is the function of this protein?
Component of 2-halobenzoate dioxygenase multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into 2-halobenzoate to form catechol.
What are the official names of this protein?
2-halobenzoate 1,2-dioxygenase small subunit, 2-chlorobenzoate 1,2-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.