PharMolix/UniProtQA huggingface dataset:
Protein: RPPH_ECO57
Sequence: MIDDDGYRPNVGIVICNRQGQVMWARRFGQHSWQFPQGGINPGESAEQAMYRELFEEVGLSRKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLVSGDAEINMQTSSTPEFDGWRWVSYWYPVRQVVSFKRDVYRRVMKEFASVVMSLQENTPKPQNASAYRRKRG
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: TM199_MOUSE
Sequence: MASSLLAGERLVRALGPGGELEREQLPRKLRAQLEAALGKKHAGSDNATGPRRLVSFRLIRDLHQHLRERNSRLYLHELLEGSDIYFPEIVKPPRNPELVARLEKIKIQLANEEYKRITRNVTCQDAQCGGTLSDLGKQVRSVKALVVTIFNFIITVAAAFVCTYLGSQYVFTEMASRVLAALIVASVVGLAELYVMVRAMEGELGEL
What is the function of this protein?
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis.  In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.  Necessary for endolysosomal acidification and lysosomal degradation (By similarity).  May be involved in Golgi homeostasis (By similarity).
What are the official names of this protein?
Transmembrane protein 199.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Partial colocalization with GOLGB1.
Protein: SYM_MYCTU
Sequence: MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDRYDVRFLTGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASKELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYFFRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPDHVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVRGHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRIAALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPEGK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGHA_DICDI
Sequence: MNKLIVVIISIILMVGIVKVNGQTKINNRPIIGILTQPTDGDMTTFGSQYIAASYVKYIESAGARVVPILYDIDIKSLTELMGSINGVFFPGGGVDFNNQTVYTDTIQSIWSQVVEFNNNGDYFPLWGTCMGFQELALLSADNFNLLSSYNSENYTVPLNFTSLAAGSRLFSLASSSIMQSLASEPITMNNHQFGLSPQTYQQTSSINTFFDVLSTNVDRDGNTFISTIEAKNYPIYGTQWHPEKPIFEWWDQEVMNHSFDSIMANQYTSNFFVNECRKSLHSFSDPSVEASTLIYNYTPQYSESTVPDFEQIYYFN
What are the official names of this protein?
Gamma-glutamyl hydrolase A, Conjugase A, GH A, Gamma-Glu-X carboxypeptidase A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C26 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: CAPP1_MESCR
Sequence: MSTVKLDRLTSIDAQLRLLAPKKVSEDDKLIEYDALLLDRFLDILQNLHGEDIKETVQELYEQSAEYERTHDPKKLEELGSMVTSLDAGDSIVVAKSFSHMLNLANLAEEVQISRRKRVKKVKKGDFMDENTAMTESDMEETLRRLIVDLKKSPQEIFETLKNQTVDLVFTAHPTQSVRRSLLQKHGRIRDCLAQLYAKDITPDDKQELDEALQREIQAAFRTDEIRRTQPTPQDEMRAGMSYFHETIWNGVPKFLRRLDTALKNIGITERVPYNAPLIQFSSWMGGDRDGNPRVTPEVTRDVCLLARMMAANMYFSQIDELMFELSMWRCTDELRERAEELHKYSKRDSKHYIEFWKQIPSSEPYRVILADVRDKLYYTRERSRQLLASEVSEIPVEATFTEIDQFLEPLELCYRSLCACGDRPVADGSLLDFMRQVATFGLCLVKLDIRQESERHTDVMDAITTHLGIGSYRDWTEEKRQDWLLSELRGKRPLFGPDLPRTDEIADVLDTINVIAELPSDSFGAYVISMATAPSDVLAVELLQRECKVKKPLRVVPLFEKLADLEAAPASMTRLFSVDWYKNRIDGKQEVMIGYSDSGKDAGRLSAAWQMYKVQEELLKVSKKFGVKLTMFHGRGGTVGRGGGPTHLAILAQPAETIGGSLRVTIQGEVIEQSFGEQHLCFRTLQRYTAATLEHGMNPPKSPKPEWRALLDQMAVVATEEYRSIVFKEPRFVEYFRLATPETEYGRMNIGSRPSKRKPSGGIESLRAIPWIFAWTQTRFHLPVWLGVGGALKHVLEKDIRNHNMLRDMYNNFPFFRVTIDLLEMVFAKGDPEIAALYDKLLVSEELQSFGERLRANYEDTKRRLLEVAGHKDLLEGDPYLKQRLRLRDPYITTLNVCQAYTLKRIRDPDFKVTERPHLSKEIMDAHKAAAELVKLNPTSEYAPGLEDTLILTMKGVAAGLQNTG
What is the function of this protein?
Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase 1, PEPC 1, PEPCase 1.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KXDL1_DANRE
Sequence: MEPTASGIFCNRMLSMVNSEDVNAIIQAQRHMLDRFEKTNEMLINFNGLSNVRLQQMNEHFLMHTRTLIEMKKDLDSIFRRIRALKGKVAKQYPEAFSNVSESSNLEDDDDEFDPIPASVATITTTATSEQSTESCDTSPDVISPTISCCSEDPSQEHTDTPTSDSHEQPVLRDEGPDSADI
What is the function of this protein?
As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery.  Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor.  May also be involved in the biogenesis of lysosome-related organelles such as melanosomes.
What are the official names of this protein?
KxDL motif-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the KXD1 family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: ATO2_YEAST
Sequence: MSDREQSSGNTAFENPKALDSSEGEFISENNDQSRHSQESICKIYTAGKNNEYIYIGRQKFLRDDLFEAFGGTLNPGLAPAPVHKFANPAPLGLSGFALTTFVLSMFNARAQGITIPNVVVGCAMFYGGLVQLIAGIWEIALENTFGGTALCSFGGFWLSFGAIYIPWFGILDAYKDKESDLGNALGFYLLGWALFTFGLSVCTMKSTIMFFALFFLLAVTFLLLSIANFTGEVGVTRAGGVLGVIVAFIAWYNAYAGIATRQNSYIMVHPFALPSNDKVFF
What is the function of this protein?
Transporter protein required for ammonia export.  Involved in acetate resistance.
What are the official names of this protein?
Ammonia transport outward protein 2.
What is the protein family that this protein belongs to?
Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
Protein: LIS1_DROYA
Sequence: MKMVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVIRLQKKVMELEAKLTEAEKEVIEGAPTKNKRTPGEWIPRPPEKFSLTGHRASITRVIFHPIFGLMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVWECR
What is the function of this protein?
Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes.
What are the official names of this protein?
Lissencephaly-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the plus end of microtubules and to the centrosome.
Protein: B2KB2_SICCD
Sequence: WIMGHMVNAIEQVDEFLNLGANAIEFDIDFDKDGIAQITHHGIPCDCGRKCTKKAIFTEYLDNIRQVTTPDDPKFREQLVLLALDLKLQRISSAKAYRAGEDVAKKLLDHYWQRGNSRARAYILLNIPSVEDYEFIRAFKDTLKNEGYESYNDKVGINFTGNEDLDKIRDVLEILGIHKQVWQADGITSCFARGTERLKEALEKRDTPGYNYINKVYAWTLVRKSIMRRSLRLGVDGVMSNNPDRVIKVLKEKEFADKFRLATYNDNPWEKFRG
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SdSicTox-betaIIB1bii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CPP1_CANAL
Sequence: MTTPLSSYSTTVTNHHPTFSFESLNSISSNNSTRNNQSNSVNSLLYFNSSGSSMVSSSSDAAPTSISTTTTSTTSMTGASANADNQQVYTITEEDSINDINRKEQNSFSIQPNQTPTMLPTSSYTLQRPPGLHEYTSSISSISSTSSNSTSAPVSPALINYSPKHSRKPNSLNLNRNMKNLSLNLHDSTNGYTSPLPKSTNSNQPRSNFIMDSPSKKSTPVNRIGNNNGNDYINATLLQTPSITQTPTMPPPLSLAQGPPSSVGSESVYKFPPISNACLNYSAGDSDSEVESMSMKQAAKNTIIPPMAPPFALQSKSSPLSTPPRLHSPLGVDRGLPISMSPIQSSLNQKFNNITLQTPLNSSFSINNDEATNFNNKNNKNNNNNSTATTTITNTILSTPQNVRYNSKKFHPPEELQESTSINAYPNGPKNVLNNLIYLYSDPAQGKIDINKFDLVINVAKECDNMSLQYMNQVPNQREYVYIPWSHNSNISKDLFQITNKIDQFFTNGRKILIHCQCGVSRSACVVVAFYMKKFQLGVNEAYELLKNGDQKYIDACDRICPNMNLIFELMEFGDKLNNNEISTQQLLMNSPPTINL
What is the function of this protein?
Protein tyrosine phosphatase that acts as a repressor of the yeast-hyphal switch.  Plays an important role in virulence.  Negatively regulates CST20-HST7-CEK1-CPH1 filamentous growth pathway.  Represses hyphal genes such as SAP4, SA5, SAP6, and HYR1, by acting through a CEK1-independent mechanism.
What are the official names of this protein?
Dual specificity protein tyrosine phosphatase CCP1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Protein: LPXH_SALCH
Sequence: MATLFIADLHLQTEEPAIVAGFLRFLAVEARQADALYILGDLFEAWIGDDDPNPLHREMAVAIKSLVDSGVPCFFIHGNRDFLIGKRFARESGMILLPQEKVLDLYGRNVLIMHGDTLCTDDAGYQAFRAKVHNPWVQRLFLTLPLFIRRRIAARMRAGSKAANSSKSLDIMDVNAQTVVAEMEKHRVQWLVHGHTHRPAVHELSVNDQPAFRVVLGAWHHEGSMVKVTPDNVELIAFPL
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NU2M_SALSA
Sequence: MNPYVLTILLSSLGLGTILTFASSHWLLAWMGLEINTLAIIPIMAQQSHPRAIEATTKYFLTQATAAAMILFASTTNAWLVGEWEIHQLSHPLATTTVMLALALKLGLAPVHFWLPEVLQGLELTTGLILSTWQKLAPFALMIQVAPTINSSLLIAMGLLSTLVGGWGGLNQTQLRKILAYSSIAHLGWMVLILQYAPSLTLLSLFLYIIMTSSAFLTLKTNNSLTINTLATSWTKSPTLAALTALVLLSLGGLPPLSGFMPKWLILQELTKQGLPLSATLAAMTALLSLYFYLRLCYAMTLTIYPNTLTATAPWRLNFTLITLPLSIITILALGLLPLTPAVTTLLTL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UREG_TOLAT
Sequence: MTQTSSPLRVGVGGPVGSGKTALLEVLCKKMRNHFEIAVVTNDIYTKEDQRILTEAGALAAERIVGVETGGCPHTAIREDASMNLAAVEALSEKFGNLDVVFVESGGDNLSATFSPELADMTIYVIDVAEGEKIPRKGGPGITKSDLLVINKIDLAPYVGARLDVMESDTNRMRPEKPWTFANLKAGQGVDTIIDFIVTHGMLTPKA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1604_LACDA
Sequence: MAFEVSAEDQDRQLTLIDEDGNEELFEVLFTFHSDDNDKSYILLYPAAVEDDDEIEVQAFSYDADEDGDVTSSDLHEITSDAEWDMVQGVLNTFLEDDRLSGDDSAE
What are the official names of this protein?
UPF0473 protein Ldb1604.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: P20D1_ASPFN
Sequence: MKATDLFHVTVLVAGALALEHQQPLIGDLSQDLNHIIDSSPLLSFHRALVQIPSISEHEKNVGEYVLDFLSSQNLTVEKQIVTPESDTEEERFNIYAYVGKNRQPDVLVTSHIDTVPPFIPYSLHAPTSDTSFIRTDLVIAGRGTVDAKASVAAIVFAALETLDENPNASIGLLFDVGEENSGVGMKHFSNSELNPTPPTYHTVIFGEPTELSLVAAHKGTLGFKLVAEGKAAHSGYPWLGESAISSLIPVLAHLDTLQDLPPEKGGLLRSETLGKSTLNIGRVHGGIAANVVPAHAEAAISVRLAAGTPEDTRTIIERAVAKVTSGDRSVYPDFGDRKAGAPPQYFDVDVDGFEVITVNYGTDAPALKIHDQRTQRVKRYLYGPGSILVAHADNEAITVGELEEAVRGYKRLIAASL
What are the official names of this protein?
Probable carboxypeptidase AFLA_000940, Peptidase M20 domain-containing protein AFLA_000940.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMH_BRASO
Sequence: MSTADPRHIPVLGPEAVAMLAPRDGGTYVDATFGAGGYTRLILATPGTRVIAIDRDSTAIAGGADLVGEANGRLTLVESRFSALAEICAAQAVGQVDGIVMDVGVSSMQLDTAARGFSFRFDGPLDMRMADTGPSAADVIAQASERDLADVIYIFGEERHSRGIARAIVAARKEQQITTTRQLADIVARVVRSKPGDIHPATRTFQALRILVNEELDELEQALSAAERILPPSGRLAVVSFHSLEDRIVKTFLAERSKIGGGSRHLPEIAQQAPSFQLLNRKPVVADEAETVANPRARSAKLRGAARTTAPAHPPSSSSAWPRLADVMRGG
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABAA_PENRF
Sequence: MATDWQPECLVAQNQPSLDPVGAHSDRALQNTTGNVQSYSDQLAHAGVTARDDQFHQYSFKYPHGPHPQPLSAPGLHQQHVAARLHQRKLRRLHSVGPNSQSRRAQSSYLKSQKYMEYRRRPRRDTGKDGEPVWSDELEDAFQQALEANPPMGRRKWSERGKSYGRNELIAEYIFKLTGKRRTRKQVSSHLQVLDSFLKGDPDWERLVREPALERSSSVHGSAPAPKWRTAVEHPSGSSHYGSHTHPSYHDHMRSMQPYAGDLPPPHYTLGSNMQETAASTIHGFSFDMWVSAPQQANRIDKALHAYTRLQGDLHHPVAPPMPLEHVNGWRSSFPQLASMVDDVNNPLDCDIILLEVNLELMTDFPPTGSRLGIQLDLDYGHPSAGDVLGVSQMDNWTCSTHIYQDSQKLLETYHDLPKTQSTKVKPLFESSWWAKLFTQLTQEKRIAEDSGNPQAARDADDHARQFFRSLSAVQEIRATSPSSCRLSNQYQGHHGDESKRMAVLAWKFRQTRPGEVGTTTWRRLIPAPDRTTTNSPRPASAVDRVPLSLDSILLNKPSHQGIYQAPHPHDLIHHPSQSQSQWPMYQSPHDNVSNLYNPSGHLDFMSSISKAEDGLNDKIAVTSVLDSFSASLAPESISSTSLHGSSGAPVMLNVHDLPLTHPGMGYTMGHETSHYVPSQHHSVNMHDSNSVLHGFFGSHTQPLDDLSHGHGSWGTHSTSIPGDVGAGSYHIPYQAEHHGPVSRESQQPHQFDGLLPSEDLMDKIVGRMSNGSGMHGAGPDAGYDNATVDAV
What is the function of this protein?
BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity).  They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity).  Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity).
What are the official names of this protein?
Conidiophore development regulator abaA.
What is the protein family that this protein belongs to?
Belongs to the TEC1 family.
What are the subcellular locations of this protein?
Nucleus. Note=localizes to the nuclei of phialides and terminal cells of mature conidia (By similarity).
Protein: A1L_LOXDE
Sequence: LIMGHMVNAIYQIDEFVNLGANSIEIDVSFDDSANPEYTYHGIPCDCRRWCTKWEYFNGFLKALRKATTPGDSKYHEKLVLVVFDLKTNSLYNYQAYDAGKKLAENLLQHYWNNGNNGGRAYIVLSIPNLAHYKLITGFKETLKNKGHPELMEKVGHDFSGNDNLDQVAKAYKKAGVTGHVWQSDGITNCIASFIRGIDRAKKAVANRDSSNGFINKVYYWTVDKYSTTREALDAGVDGIMTNYPDVIANVLNESAYKTKFRLATYADNPWETFKN
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LdSicTox-alphaIB2, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYT_LISMH
Sequence: MKITFPDGAVKEFEPGVSTADIAASISPGLKKKALAGKLNGELLDLVTPIHEDGAIEIVTPDHEDALGILRHSTAHLMAQALKRLYPDVKFGVGPAIESGFYYDIDTEAVISDESLVEIEKEMQKIVRENVPIEREVVSREEAIKRFKAIGDQYKLELIEAIPEDETVTIYTQGEFFDLCRGVHVPSTGKIQVFKLLSVAGAYWRGDSNNKMLQRIYGTAFFDKNGLKEFIQMQKEAKERDHRKLGKELDLFANSIEVGQGLPLWLPKGATIRRVIERYIVDKEERLGYNHVYTPIMANVELYKTSGHWDHYHEDMFPTMKMDNEELVLRPMNCPHHMMIYKNDIHSYRELPIRIAELGMMHRYEMSGALSGLQRVRGMTLNDAHVFVRPDQIKDEFKRVVELILEVYKDFDIKDYSFRLSYRDPKNTEKYFDDDAMWEKAQAMLKSAMDEMEMDYFEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGEDGEKHRPVVIHRGVVSTMERFVAYLIEEYKGAFPTWLAPVQMELIPVNADAHLDYAKGVQDKLQRAGLRAEVDDRNEKLGYKIREAQTKKIPYALVLGDQEVEAGSVNVRRYGSKDSETMDLDAFIAQVVAEVSKY
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_ACIF2
Sequence: MSTGITIALSKGRILQEAIPLFAGAGIHLAEDPEESRKLIIPSTDPTVRFLVIRASDVPTYVTWGAADVGIAGKDVLLEQEGLDLYEPLDLRIGICHMAVAEPAAMAADDAPQSWERVRIATKYPHITRHYFHSRGVQTEIIKLYGSMELAPLVGLADRIVDLVSSGRTLKENGLVEVEEIMPISSRLVVNRAAMKLKRRAIETLIRQLEAQVTP
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTHC_ECOLI
Sequence: MIETITHGAEWFIGLFQKGGEVFTGMVTGILPLLISLLVIMNALINFIGQHRIERFAQRCAGNPVSRYLLLPCIGTFVFCNPMTLSLGRFMPEKYKPSYYAAASYSCHSMNGLFPHINPGELFVYLGIASGLTTLNLPLGPLAVSYLLVGLVTNFFRGWVTDLTTAIFEKKMGIQLEQKVHLAGATS
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.  The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport.  It can also use D-mannitol.
What are the official names of this protein?
PTS system glucitol/sorbitol-specific EIIC component, EIIC-Gut, Glucitol/sorbitol permease IIC component.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPO1C_METMA
Sequence: MMSISEATVDSMIKDLPLPSNILKTLRDDVIKAGVSKKEMEEIIERVMEEYTVSCIEPCDAAGVVAAQSIGEPGTQMTMRTFHYAGVAEINVTLGLPRLIEIVDARKIPSTPMMTIALSKEHPEDYAYDREKTRALAWEIEATKIDHIADVTTDLSQMKLIIDLHEKAMEGRNITIDRVKEKFNEELNVLVSISPDIDNQIVITPGEPSYRELLQLAKSIHNVTLKGIEGIKRVVVRKEGEEYTLYTEGSALREVLQFEGVDRTRTSTNNINEIYEVLGIEAARNAIIKEATDTLREQGLTVDIRHIMLVADLMTSDGEVKQIGRHGISGEKASVFARAAFEVTVNHLLDAGMRGYVDQLQGVTENIIVGQPIRMGTGDVHLISRKAEKVVEVPPEIETAEEIEVEEG
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Forms part of the jaw domain.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo1C, DNA-directed RNA polymerase subunit A''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB3_MURHE
Sequence: VEWTDAERTAILTLWKKINIDEIGPCAMRRLLIVSPWTQRHFSTFGNISTNAAIMDNDLVAKHGSTVMGGLDRAIKNMDDIKGAYRELSKKHSDQLHVDPDNFRLLAECITLCVAGKFGPKEFTADVHEAWYKFLAAVTSALSRQYH
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-3, Beta-3-globin, Hemoglobin beta-3 chain, Hemoglobin beta-III chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: HEM1_SYNE7
Sequence: MHLAVVGLSHRTAPVAVREKLSIPEQQVEAAIQQLKSYPHIEEVAILSTCNRLEIYCVTRATEPGVREITQFLSEHSHLPLGELRPHLFVLLHQDAVMHLMRVAAGLDSLVLGEGQILSQVKTMYKLGQQYEGVGRILNRLLKQAVTAGKRVRTETSIGTGAVSISSAAVELAQLKVIARDDRSDGNLAGQRVLILGAGKMSRLLVQHLIAKGADTIQILNRTLGRAEELAKQYGGDLQIQVGLLSGLMNAIVEADIVFTSTSATDPILDRAKLEMVLAPEQRLMLIDIAVPRNVAADVVELTSVESYNVDDLREVVAQNQESRRKLAEEAEALLEEEVDAFDNWWQSLDTVPTINCLRDKIEMIREQELEKALSRLGTEFGDKHQAVVEALTRGIVNKILHDPMVQLRSQQDIEARRRAVDALQMLFNLDPQGQLSS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: ACCA_ALIF1
Sequence: MSLNFLEFEKPIAELEAKVEALREISRRGGENALDLEKEIKQLEDKCLELKKKTFSDLGAWEVAQLARHPERPYVLDYIEHMFTEFDELAGDRAFADDKALVGGIARLDGRPVMVIGHQKGRGTKEKVIRNFGMPKPEGYRKAKRLMQMAERFNMPVITFIDTAGAYPGVGAEERGQSEAIAMNLKIMSELSVPVICNVVGEGGSGGALAIGVGDYVNMLQYSTYSVISPEGCASILWRDSDKAPQAAEAMGLVAPRLKELELIDTIIDEPLGGAHRDHKATAENIKQRLLEQLKELDAFDNEALLERRYQRLMSYGYC
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.