Protein: FUS1_GIBF5
Sequence: MAGNQYLPKEPIAIIGTSCRFPGGANTPSKLWDLLCEKRDVQSRIPNDRFNVDAFYSTNGDKNGCTDVKNAYVLSEDIRVFDASFFKINPREAEAMDPQQRLLLEAVYEATEAAGLPMEDLKGSDTAVYVGCMTGDYHEMLMRDPQDMPKYMATGTARSILSNRISYLFDWKGPSMTIDTACSSSLVAVYDAVTALRNGVSKIACAGGANLILGPEMMISESKLHMLSPTGRSRMWDASANGYARGEGVAAIMMKTLSQALADGDHIQGVIREIGVNSDGRTNGITLPSPEAQKVLIRQTYKKAGLDFFKDRCQFFEAHGTGTPAGDPLEARAIHEAFFTDGDTVPEPMYVGSVKTAIGHLEGCAGLAGLIKALEAVKRGIIPPNQLFENLNPALKPYVSNLRLPTESKPWPKLTPGSPRRASVNSFGFGGTNVHAIIEQFDNVHTQTSSSDGIISTPLVLSANSDLSLRKQIAHFAEAIEHNDKGKIDRVIFTLTQRRSQLPLRTYFSGYDLQSLQQKLRDATAENAVLPFISQTVPPGRPPRILGVFTGQGAQWPTMGREILKASPFARAVIASLEESLASLAQPPAWTLTEQIMADKESSRLSEAAISQPLCTAVQIMVVELLRKAGITFNCVIGHSSGEITAAYTAGFLSASDAIRVAYLRGVCAKLAGGENGETGSMIAVGLSYEEASAFCEENFAGLVDVAASNAPTSTTLSGDKASIDDAKALLDAQGTFARILKVDTAYHSHHMNPCAQPYLDKLQAARVKSLPGDESVEWYSSVLGERITASLHGEALCDEYWVENMVNPVLFSVASELVAEASLPCHVALEVGPHPALKGPFNQTYKRATGSPLPYQGTVARNIHDVEGLSDSLGFLWSHLGKSAVDFTAYSQAFSPSITAMADGLPPYAWDHTQSFWRESRKSLNYRQRTQPPHPLLGARSVEDTADSMRWINYLRLDDVPWLEGHKVEGQVVYPAAGYLVMAMEAARAIDTTKGIQLIELSDVYILSAIQLTEGSQALETVFTLQVERNEPTFSTASWTLSTPMSGRNDSWKCNAKGQLRVEFGCSDDAARLPSRNKPIASLTSVNMERFYSALANIGLEYTGEFKQLKSIDRQLGLATAHVSQVVPDFPAMIHPALLDGAFQSIFAAYCWPDDGSLQAPFVPTFFRSLRIANTGHLRHGEDLVVDSFLTNTNERELTADMDVFQSSQGQPVLQLQGLTCTSLLRPGPSNAKELYTKTEWEVDIASGIAQSDTQDQDTASDLELVDLCERLSYFYLRELNNAVGREEVSGFDWHYRRIFEWIDHLFPLIQSGQHATIKTEWSSDSRDWLMQQSARFPGRIDLQLIQAVGENLPSVVRKQTTMLEHMVKDDMLNRIYKFGLGFERANVYLGRISKQIAHRYPRMNILEIGAGTGGATKGIMESLGTTFETYTFTDISTGFFEAAAEAFDHWADKMIFKPLNIESDPTEQGFPEGHYDFIIASNVLHATKSLTVTMRNTRKLLKPGGQLLLLEVTSDIVRVKLMMSGLSGWWLGGDDGRRYGPTIPVSQWDALLKQTGFSGVDKTVNDFVDAEKYMTSVMLSQAVDDRIELLRQPRLTFSDWLSSQSITVVGGYFRDIGRDILEILHQMNHGASQPVIHHVGSFEELALSNIQARSALVLEDLDEPILKDLTDDKLRGVQRLINESRQVLWVSKGCQRDEPFANMSIGMCRSLASEYPHIHLQHVDIEGRVSPMTASLLVEAFLRLVYRASLKSDDLVWSIEAELVLREDKWFIPRVKSDEALNNQLNASKMTIHSQKTLHGDTIEIQQRSNQFVIVDPVPCVPVSVSSPPVAITVTHSLLFPFQVGTKSSGYLCYGYTDSQPRTRVLAISEVNRSKVSVSPFSVWDLSSSEIDAADLLRKTALAITADRLLSDFEAGATVLIHESDELLGAALQWKAAELDLNVIMTTSESSRERSTGAMFIHALAPERLVNHIMPQHTKAVIDLSGKDYSIVGSPLRRCLPANCKFHQLQDILGNASQGVADPIIHGVRDASRSSLQLCGDGPVVKLSDLPSLRASIKDYATVVEFSANTTIPAIVQPLEGSRLFRSDRTYLLIGCTGGLGKALCRWMVSCGVRHLALTTRNVAAIDQVWLEELRIQGAQVNLYQADVSDKAALLQAYDQIVKEMPPICGTANAALLLSDRTFTELKVNDFTKVFGPKVKGTQNLHELLLDQKLDFFIMFSSLASVVGNRGQANYAASNLFMSAIAEQRRAKGLAASVMHIGMVLGVGYVSSTGAYEATLRSSNYMAISETDLLNMFSQAILVGQPNSTHAPELITGLNRFSLEPEAQKYFWRDNMRFCHHTLEEEHQERASATKVSISQRLSEAKGTAEILAVVEEEFCTKLERLLQAEAGFVKTSQSLLGLGVDSLVAAEIRSWFLKELEVDTPVLEILNTASITELCSTVVSHLPTISGEIAPKTEVTKQAIKTLNVVETSTAVSSALPTENEPFTIRNSPNSTQVTSEAGVDEDTSIHSKFDRAGPLSFAQERLWFLQQFLRDHSTYNVTMHYHISGPLRLHDLEMAFQQLIHRHESLRTSFFIDPDTDLPTQAVLKDSSFKLEQKHNSTAKIEYKAMQEMSYDLENGKVTKAVILPDSDGEFDLIFGFHHIALDGYSAQIMVRDLAIAYAGQTLPSKQQDYLDFAIAQKTAKVPDTTLAYWRSEFRELPPTLSVFDFAETKTRTPLTDYTTRALERTISIDQGRSIKAVAKCLDATPFHIHLAALQVVLSDLASTKDLCIGITDANKYDVTHIDTVGFFVNLLPLRLKISLSQTLAEVVANAKSKANSALSHSDIPFDVLLDEVKLPRSTTHSPLFQVILNYKMGSTQKVPLADCQAQLVAFKDASNPYDLTFDIETYHDGSACISVKTQEYLYSESELSFILDSYLQTLALFASEPSRTIDQICRPTAEQIDKALTLGRGERIPSPRLETLCHYFEEFVVKQPDDTALVTDKGQALTWCQLKALVNQIAMTFVEAGAKQDSRVGVYCEPSMYILPTLLAIAEVGGVYVPLDAQNPIKRLQLMVDDCQPDVILIDDSTATTARELETNAIVINVNTIKADPSNTFHMDIRARGNGMGYIFYTSGTTGVPKAVALTHTSLVHHFDGFIHYNNLSKCRMLQQAPLGFDMSLTQMTLAIMLGGTLIVASSETRKDPMQLAQLMLAEKVTHTFMTPTLALSVIHHGYEYLRQCVNWEHASLAGEAMTTRVTREFKRLGLRNLELLNGYGPTEITIIATCGSNELGDTLRDTHNPSIGRALPNYSCYILDENMQPVRPGLAGELVIGGAGVAIGYLNRQDLTEVKFLRDPFSPAEDIARGWTRMYRTGDKARFLSDGRLCFLGRIAGDSQIKLRGFRIELEDIASTIVRASDGKIPEAAVSLRGEGDSAYLVAFVILSQFNSPSDENGYLKQLLEELSLPRYMKPARIISIDQLPMNASGKLDQYALDALPVPHEEDIVDKPLTETQERLKLGWLKALPFIDAAIGPDTDFFSAGGNSLRIVSLREYITREFGVTVSVFDLFQASTLGEMAAKIDGSTTQGPTTMPIDWNEETRIDADLSIVGAQEPLPSETANDLQVALTGATGFLGVSILKTLLEDKRVSKVHCLAVRSSSNTSDPVFSSSRVACYPGDLSLPRLGLSQEQFDQLAKTVERIIHNGADVSFLKTYQSLKRSNVSSSRELARMAITRRIPVHFVSTGGVVQLTGQDGLDEVSVADSVPPTDGSLGYVASKWASEVILEKYASQYNLPVWIHRPSNITGPNAPKADLMQNIFHYSVKTASLPDLASWSGCFDFVPVDVVAAGIAGSIYETQDTVAYKHHCGREKISVEDLPSYLEAKHGKIETISVEEWLERSKAAGFDEVTAALVEKTLSRGGIVPWLRKEAN
What is the function of this protein?
Fusarin C synthetase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:22865073, PubMed:23932525).  Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (PubMed:23932525).  The roles of the other FUS members are yet undetermined (PubMed:23932525).  The fusarin C synthetase FUS1 is responsible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure (PubMed:23932525).  The cytochrome P450 monooxygenase FUS8 participates in multiple oxidation processes at carbon C-20 and is able to use the FUS1 product as substrate, resulting in formation of 20-hydroxy-prefusarin (PubMed:23932525).  This reaction seems to be essential before the 2-pyrrolidone ring closure can be catalyzed by FUS2, generating 20-hydroxy-fusarin (PubMed:23932525).  FUS8 is able to further oxidizes carbon C-20 after ring closure, resulting in the formation of carboxy-fusarin C (PubMed:23932525).  As the last step, FUS9 methylates the hydroxyl group at C-21 to generate fusarin C (PubMed:23932525).  Fusarin C can then rearrange to epi-fusarin C, the (z)-isomers, and fusarin A and fusarin D (PubMed:23932525).
What are the official names of this protein?
Fusarin C synthetase, FUSS, Fusarin C cluster PKS/NRPS FUS1, Fusarin biosynthesis megasynthetase, Fusarin biosynthesis protein 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.