PharMolix/UniProtQA huggingface dataset:
Protein: CR3L2_HUMAN
Sequence: MEVLESGEQGVLQWDRKLSELSEPGDGEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLCEEPRAQSPFTHITTSDSFNDDEVESEKWYLSTDFPSTSIKTEPVTDEPPPGLVPSVTLTITAISTPLEKEEPPLEMNTGVDSSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPSRAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHSLQEPYTASVVRSRNLLIYEEHSPPEESSSPGSAGELGGWDRGSSLLRVSGLESRPDVDLPHFIISNETSLEKSVLLELQQHLVSAKLEGNETLKVVELDRRVNTTF
What is the function of this protein?
Transcription factor involved in unfolded protein response (UPR).  In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane.  In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2.  The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes.  Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity).  In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827).  In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 2, cAMP-responsive element-binding protein 3-like protein 2, BBF2 human homolog on chromosome 7.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Note=Upon ER stress, translocated into the nucleus.
Protein: ENV_HV2KR
Sequence: MDSRNQLIVAILLTSACLIYCAQYVTVFYGIPAWKNASIPLFCATRNRDTWGTIQCLPDNDDYQEIPLNVTEAFDAWNNTVTEQAVEDVWNLFETSVKPCVKLTPLCVQMECNSTSTESSNSTSEGSTVPEILNETTSCITNNSCSDLGSEEVVDCRFNMTGLQLDKPQQYSETWYSKDVVCDTTNGTSRKCYMNHCNTSVITESCDKHYWDAMRFRYCAPPGLCLLRCNDTNYSGFEPKCPKVVAATCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTIISLNTHYNLTMHCKRPGNKSVLPITLRSGRVFHSRPIINERPKQAWCWFGGDWKKAMQEVKQTLVKHPRYRGTNDTQKINFTQPGKGSDAEVVYMWTNCRGEFLYCNMTRFLNWIENRAHPQRNYAPCHIRQIINTWHRVGQNIYLPPREGELVCNSTVTSIIANIDMFDNQTSITFSAEVAELYRLELGDYKLVEITPIGFAPTSEKRYSSAPQRNKRGVFVLGVLGFLATAGSAMGAASLTLSAHPGLYWAGIVQQQQQLLDVVKRQQEMLRLTVWGTKNLQTRVTAIEKYLRDQARLNSWGCAFRQVCYTTVLWENNSIVPDWNNMTWQEWEQQTRDLEANISRSLEQAQIQQEKNMYELQKLNSWDVFGNWFDLTSWIKYIQYGVYVIIGIIALRIVIYVVQLLSRLRKGYRPVFSSPPGYIQQIHIHKDWEQPDREETDEDAGNSIGDSSWPWPIAYIHFLIRQLIRLLTGLYSVCKDLLSRSFPTLQLIFQSLQRALTTIRDWLRLTIAYLQYGCEWIQEVLQVLARTTRETLASAWRDLWGAMGRIGRGILAVPRRIRQGAELALL
What is the function of this protein?
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers.  Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells.  Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells.  This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: HAF1_ARCFU
Sequence: MEVLRVELPLAPVERLLRKAGASRVSEDAKVELAKAIEEYAMQIGKKAAELAKHAGRKTVKVDDIKLALREL
What is the function of this protein?
Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils.  Increases the resistance of DNA to thermal denaturation (in vitro).
What are the official names of this protein?
Probable archaeal histone A1-1.
What is the protein family that this protein belongs to?
Belongs to the archaeal histone HMF family.
What are the subcellular locations of this protein?
Cytoplasm. Chromosome.
Protein: C1D_BOVIN
Sequence: MAGEGINEDYPVEIHEYLSTFENSIGAVDEMLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKNALWEPKPKNASKVANKGKSKN
What is the function of this protein?
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5. 8S rRNA; this function may include MPHOSPH6.  Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA.  Can induce apoptosis in a p53/TP53 dependent manner.  May regulate the TRAX/TSN complex formation.  Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
What are the official names of this protein?
Nuclear nucleic acid-binding protein C1D.
What is the protein family that this protein belongs to?
Belongs to the C1D family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleolus. Note=EXOSC10 is required for nucleolar localization. Colocalizes with TSNAX in the nucleus.
Protein: DPP5_TRISH
Sequence: MAAAKWLIASLAFASSGLAFTPEDFISAPRRGEAIPDPKGELAVFHVSKYNFDKKDRPSGWNLLNLKNGDISVLTTDSDVSEITWLGDGTKVVYVNGTDSVEGGVGIWISDAKNFGNAYKAGSVNGAFSGLKLAKAGDKINFVGYGQSTTKGDLYNEAAAKEAVSSARIYDGLFVRHWDTYVGTQFNAVFSGSLTKNGDKYSFDGKLKNLVQPVKYAESPYPPFGGSGDYDLSSDGKTVAFMSKAPELPKANLTTSYIFLVPHDGSRVAEPINKRNGPRTPQGIEGASSSPVFSPDGKRIAYLQMATKNYESDRRVIHIAEVGSNKPVQRIASSWDRSPEAVKWSSDGRTLYVTAEDHATGKLFTLPADARDNHKPSVVKHDGSVSSFYFIGSSKSVLISGNSLWSNALYQVATPGRPNRKLFYANEHDPELKGLGPKDIEPLWVDGARTKIHSWIVKPTGFDKNKVYPLAFLIHGGPQGSWGDSWSTRWNPRVWADQGYVVVAPNPTGSTGFGQKLTDDITNDWGGAPYKDLVKIWEHVRDHIKYIDTDNGIAAGASFGGFMVNWIQGQDLGRKFKALVSHDGTFVGSSKIGTDELFFIEHDFNGTFFEARQNYDRWDCSKPELVAKWSTPQLVIHNDSDFRLSVAEGVGLFNVLQEKGIPSRFLNFPDETHWVTKPENSLVWHQQVLGWINKWSGINKSNPKSIKLSDCPIEVIDHEAHSYFDY
What are the official names of this protein?
Dipeptidyl-peptidase 5, Dipeptidyl-peptidase V, DPP V, DppV.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9C family.
What are the subcellular locations of this protein?
Secreted.
Protein: ASTA_YERPP
Sequence: MMKVRPVERRDLADIFELAGKTGVGMTSLPQNEQHLAARIERALNTWQGSLDPGEQGYLFVLEDSEQQKVVGVSAIEVAVGLNDPWYNFRVGTLVHASKALNVYKSVPTLFLSNDHTGYSELCTLFLDPDYRKDKNGPFLSKVRFLFIAAFRQYFSRKVIAEMRGYTDEQGRSPFWESVGRHFFSIEFAKADYLSGTGQKAFIAELMPKHPLYVDFLAEEARAVIGQVHPHTAPARAVLETEGLQYQGYVDIFDGGPTLEANTDDVRVVRDSSKRTVVIKDYDIEDYDIDPNGRLYLVANDHYHHFRAILMNTHLSDERLRLTPESAEALGVAAGDSVRIVSLFAPETKR
What is the function of this protein?
Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.
What are the official names of this protein?
Arginine N-succinyltransferase, AST, AOST.
What is the protein family that this protein belongs to?
Belongs to the arginine N-succinyltransferase family.
Protein: SYFA_ACTPJ
Sequence: MQHLKELTEKARSALDALDQGLDALEEFRVEYFGKKGHFTALMQELRNVAAEERPAIGAKINEAKQTILDILNAKKEAWEQEALNAKLAAESIDVSLPGRKTELGGLHPVSITIERVVKFFSELGFTVASGPEIETDYYNFDALNIPAHHPARADHDTFWFDAQRLLRTQTSGVQIRTMENMQPPIRIVAPGRVYRNDYDQTHTPMFHQIELLYVDKKANFTELKGLIHDFLKAFFEEDLQVRFRPSFFPFTEPSAEVDVMRQNGKWLEVLGCGMVHPNVLRNVGIDPEEYSGFAVGMGVERLTMLRYNVTDLRSFFENDLRFLKQFK
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_SHEFN
Sequence: MKPFPRAEISRYALQSNLAQLRLIAPNSKIMAVVKANGYGHGLLNVAECVGLLNYVESVCKYHGGADGFGLARLEEALQLREGGVKGKLLLLEGFFRQSDLPTLVSHNIDTVVHHESQLQMLETIALDKPVTVWIKIDTGMHRIGFSLEQFNSIYQRLLACPQVAKPIHLMTHFACADEPDNPLTQTQMNAFEQQVSGLEGDRTLANSAGTLFWPTSQADWVRPGIALYGVSPVVGDRGVNHRLIPAMELVSNLIAVREHKAGDSVGYGASWTAKKDTRLGVVAIGYGDGYPRNAPEGTPVWINGRRVPIVGRVSMDMLTVDLGADAQDNVGDSVQLWGKALAVEEVAEHIGTIAYELVTKLTPRVVVELLD
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: TRMA_ECOK1
Sequence: MTPEHLPTEQYEAQLAEKVVRLQSMMAPFSDLVPEVFRSPVSHYRMRAEFRIWHDGDDLYHIIFDQQTKSRIRVDSFPAASELINQLMTAMIAGVRNNPILRHKLFQIDYLTTLSNQAVVSLLYHKKLDDEWRQQAEALRDALRAQNLNVHLIGRATKTKIALDQDYIDERLPIAGKEMIYRQVENSFTQPNAAMNIQMLEWALDVTKGSKGDLLELYCGNGNFSLALARNFDRVLATEIAKPSVAAAQYNIAANHIDNVQIIRMAAEEFTQAMNGVREFNRLQGIDLKSYQCETIFVDPPRSGLDSETEKMVQAYPRILYISCNPETLCKNLETLSQTHKVERLALFDQFPYTHHMECGVLLTAK
What is the function of this protein?
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
What are the official names of this protein?
tRNA/tmRNA (uracil-C(5))-methyltransferase, tRNA (uracil(54)-C(5))-methyltransferase, tRNA(m5U54)-methyltransferase, RUMT, tmRNA (uracil(341)-C(5))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
Protein: 3NO22_NAJAT
Sequence: MKTLLLTLVVVTIVCLDLGYTLTCLNCPEMFCGKFQICRNGEKICFKKLHQRRPFSLRYIRGCAATCPETKPRDMVECCSTDRCNR
What is the function of this protein?
Binds with low affinity to muscular (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and very low affinity to neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR).
What are the official names of this protein?
Probable weak neurotoxin NNAM2, TA-N9.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily. Orphan group II sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_DESVH
Sequence: MLGFLFKKVFGSKNDRYIKRLRPIVAAINALEPQMQSLRDEDFPVRIAEYRQQVEEGRKLDDMLPEVFALVREAGKRVFNMRHFDVQLVGGMALHHGKIAEMKTGEGKTLVATLPVVLNALTGKGVHVVTVNDYLAKRDAAWMGQLYNFLGLSVGVIVHGLDDEQRKAAYGADITYGTNNEFGFDYLRDNMKFYAEQLVQRGHNFAIVDEVDSILIDEARTPLIISGASEESTGLYRHMDEIVRKLTRDTHFTVDEKARTAMLTDEGVAFCEKLVGIDNLYDPGNITTQHHLMQALKAHNLFRRDVDYIVKEGQVVIVDEFTGRLMPGRRFSDGLHQALEAKEAVKIEAENQTLASITFQNYFRMYAKLAGMTGTADTEAVEFHQIYSLEVVSIPTNKPMQRKDFADAIYRTKREKYDAIAQAIAELHKAGQPVLVGTISIETSELLSTMLKKTGVPHSVLNAKHHEKEAEIVALAGQRGHVTIATNMAGRGTDIVLGEGVRELGGLHILGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLEDDLMRLFGSERISGLMEKLGMEEGEPIEARMVSRAIENAQKRVEGHNFEIRKTLLDYDNVMNQQREVIYTLRRDAMSAPDLGPTMEEFLDDVLEDVYAPAEGGEAPSADTVAAVWGRLADVCNITRVMQPAPALPTRDEARAAVLSILHELREDTGESYRDIIRYFMLEELDRCWKEHLRNMDHLRDGIGLRGYGQRDPKLEYKREGFAMFQEMLFRIKEGVFRSLTRLRVQRVEEEAFRHKEQPAAVAYSGGEAEAGPAQPHREDPKVGRNDLCPCGSGRKYKKCCGA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RL3_PSE14
Sequence: MTIGVVGRKCGMTRIFTEEGVSIPVTVIEIEPNRVTQFKTEETDGYRAVQVTVGERRASRVTAAQAGHFAKANVAAGRTVMEFRLEEGDYQAGDQINAEIFAAGQLVDVTGQSKGKGFQGTIKRWNFRGQDNTHGNSVSHRVPGSIGQCQTPGRVFKGKKMSGHMGAERVTVQSLELVRVDAERNLLLVKGAVPGATGGNLVVRPAAKARG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: RBL_STRLC
Sequence: MSPQTETKASAGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIESVVGEEDQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLAGGFTANTSLAFYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREMTLGFVDLLRDDFIEKDRSRGIFFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREACKWSPELAAAC
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ENPLL_HUMAN
Sequence: MAETIQEVEDEYKAFCKSFSKESDDPVACIHFTAEGEVTFKSILFVPTFVPRGLFDEYGSKKSDYIKLYVRCVFITDDFRDTMPKNLNFVKGVVDSGGLSLNVSCETLQQHKLLKVIRKKLVHKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTCLAKLLRFQSSHHPADITSLHQDVERMKEKQDKICLMAGGYEVIYLTEPVVEYCIQALPEFDGKRFQNVAKEGVKFDDSEKTKESHEAVEKEFEPLPNWVKDKAIKDKIEKAMVSQCLTESLCALVASQYGWSGNMERIMKAQAYQTGKGISTNYHASRKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVEEPDEEPEETAEDKEQDKDKEMDVGTDEEKQETAKESTAEKDEL
What is the function of this protein?
Putative molecular chaperone.
What are the official names of this protein?
Putative endoplasmin-like protein, Putative heat shock protein 90 kDa beta member 2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
Protein: DCD_ENT38
Sequence: MRLCDRDIEAWLDEGRLSITPRPPVERINGVTVDVRLGNKFRTFSGHTAAYIDLSGPKDEVSAALDRVMSDEIVLAEGEAFYLHPGELALAVTFESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGHIVLEFFNAGKLPLALRPGMMIGALSFEPLTGPADRPYNRRQDAKYRDQQGAVASRIDKD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: ISPF_CLOTE
Sequence: MRVGIGYDVHKLVDGRDLIIGGEKIPFEKGLLGHSDADVLCHAIGDSILGAAALGDIGRHFPDTDNRYKGYSSLKLLEEIKRIINEKGYYITNIDSTIIAQKPKMLAYINNMRKNISKVLDISIEDINIKATTEEELGFTGKQLGIKAQSICLLNKNI
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: MRAY_CUPTR
Sequence: MLLALAQWLQNDYSFLRVVNYLTFRAVMANVTALVIGLAFGPWVIRKLTELKVGQAVRTIGPQTHLVKSGTPTMGGVLVLVSIAVSTLLWCDWGNRFIWVVMLVTFGYGAIGWVDDYRKVVYRDPRGMSSREKFFWQTLIGLVAAVYLAFSVSESSNVRVWELFLNWVEGGLSLDMPYKSNLIVPFFKEISYPLGVAGFIVLTYLVIVGSSNAVNLTDGLDGLVIMPVVLVGGGLGVFAYVMGNAVYSKYLLFPHIPGAGELLIFCSALGGAGLAFLWFNAHPAQVFMGDVGALALGGALGTVAVIVRQEIVLFVMGGIFVVETLSVMAQVTWFKITKRRYGEGRRLFRMAPLHHHFELGGWKETQVTVRFWIITMLLVLIGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAK_SHESR
Sequence: MGKIIGIDLGTTNSCVAVLDGGKARVLENAEGDRTTPSIIAYTDDETIVGQPAKRQAVTNPNNTFFAIKRLIGRRFKDDEVQRDVNIMPFKIIQADNGDAWVESRGNKMAPPQVSAEILKKMKKTAEDFLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAYGIDKKQGDNIVAVYDLGGGTFDISIIEIDSNDGDQTFEVLATNGDTHLGGEDFDNRLINYLADEFKKEQGLDLRKDPLAMQRLKEAAEKAKIELSSTNQTEVNLPYITADATGPKHLVVKITRAKLESLVEDLIIRTLEPLKVALADADLSVSDINEVILVGGQTRMPKVQEAVSNFFGKEPRKDVNPDEAVAVGAAIQAGVLSGDVKDVLLLDVTPLSLGIETMGSVMTKLIEKNTTIPTKAQQVFSTADDNQSAVTIHVLQGERKQASANKSLGQFNLDGIEPAPRGMPQIEVMFDIDADGILHVSATDKKTGKKQNITIKASSGLSEEEVAQMVRDAEAHAEEDKKFEELVQSRNQADGLVHATKKQVEEAGDALPADDKAKIEAAMSAVEVATKGNDKEAIEKATQELIEASAKLMEIAQAKAQTQGGAQEGAAKQSNATADDVVDAEFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: FDB38_GIBM7
Sequence: MVKSMRFRDLEVPTPGFGAMGISFALGNDLSYEEAEPVLLKALEQGCTFWDTAVSYGPGKNEKILGDFIRKYNCRDKLFIASKCGIAAFEDGSVTNSAEHIKTYIEGTIERLGFTPDLYYIHRMDPNTPLEESIPALDSLRKQGKTKYIGLSECSAETLRKANSIARIDAVQAEYSAFETIHETDGLIDTARELDIEFIAYGPLGHGWLVEDFPYQTPEDFAPEDYRRQIPKWQGENFYANKRIADGFRELAKRKKCTLPQVALAWVAAQGLISIPGTTKPERLVENFTSRDIELTEEEIKDMRKLVDVLKPQGDRYNEVAMRSIGK
What is the function of this protein?
Aldo-keto reductase; part of the Fusarium detoxification of benzoxazolinone cluster 2 (FDB2) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:19302487, PubMed:26808652).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).  The first step in the detoxification of benzoxazolinones involves the hydrolysis of the cyclic ester bond of benzoxazolinones by the FDB1 cluster gamma-lactamase MBL1 to aminophenols (PubMed:26808652, PubMed:12788712).  MBL1 is able to convert BOA into 2-aminophenol (2-AP), as well as MBOA into 5-methoxy-2-aminophenol (2-AMP) (PubMed:26808652, PubMed:12788712).  The FDB2 cluster N-malonyltransferase FDB2/NAT1 then metabolizes aminophenols via N-malonylation to non-toxic malonamic acids (PubMed:19302487, PubMed:12788712).  FDB2/NAT1 converts 2-AP into N-(2-hydroxyphenyl) malonamic acid (HPMA) and 2-AMP into N-(2-hydroxy-4-methoxyphenyl) malonamic acid (HMPMA) (PubMed:19302487, PubMed:12788712).  The duplicated dienlactone hydrolases DLH1 and DLH2 may provide redundant function for hydrolyzing the lactone moiety in the BOA molecule (Probable).  The roles of the amidases an other enzymes encoded by the 2 FDB clusters have not been identified so far (Probable).
What are the official names of this protein?
Aldo-keto reductase FVEG_12638, Fusarium detoxification of benzoxazolinone cluster 2 protein FVEG_12638, FDB2 cluster protein FVEG_12638.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Protein: SOMA_ACALA
Sequence: MDRVVLMLSVLSLGVSSQPITDGQRLFSIAVSRVQHLHLLAQRLFSDFESSLQTEEQRQLNKIFLQDFCNSDYIISPIDKHETQRSSVLKLLSISYRLVESWEFPSRSLAGGSAPRNQISPKLSELKTGIHLLIRANEDGAELFPDSSALQLAPYGDYYQSPGTDESLRRTYELLACFKKDMHKVETYLTVAKCRLSPEANCTL
What is the function of this protein?
Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes.  Implicated as an osmoregulatory substance important for seawater adaptation.
What are the official names of this protein?
Somatotropin, Growth hormone.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRYB_RAT
Sequence: MKICIFFTLLGTVAAFPTEDNDDRIVGGYTCQEHSVPYQVSLNAGSHICGGSLITDQWVLSAAHCYHPQLQVRLGEHNIYEIEGAEQFIDAAKMILHPDYDKWTVDNDIMLIKLKSPATLNSKVSTIPLPQYCPTAGTECLVSGWGVLKFGFESPSVLQCLDAPVLSDSVCHKAYPRQITNNMFCLGFLEGGKDSCQYDSGGPVVCNGEVQGIVSWGDGCALEGKPGVYTKVCNYLNWIQQTVAAN
What are the official names of this protein?
Trypsin V-B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.