PharMolix/UniProtQA huggingface dataset:
Protein: GBRA1_RAT
Sequence: MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
What is the function of this protein?
Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2540033, PubMed:1977069, PubMed:1376242).  Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity).  The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).  The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity).  GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity).  Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286).
What are the official names of this protein?
Gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
Protein: ISPG_BRUA1
Sequence: MSSETVSYFSHPFPRRQSVGVSVGGVIVGGSAPVVVQSMTNTDTADVDSTVAQVAALHRAGSEIVRITVDRDESAAAVPKIRERLERLGHDVPLVGDFHYIGHKLLADHPACAEALSKYRINPGNVGFKDKKDKQFADIVEMAIRYDKPVRIGVNWGSLDQELLTALMDRNQAEGAPLSAQDVMREAIVQSALISANLAEEIGLGRDKIILSAKVSQVQDLIAVYTMLAQRSNHALHLGLTEAGMGTKGIVASSAAMGILLQQGIGDTIRISLTPEPGGDRTREVQVAQELLQTMGFRQFVPIVAACPGCGRTTSTVFQELAQTIQEDIRRNMPLWREKYPGVEALSVAVMGCIVNGPGESKHADIGISLPGTGETPSAPVFVDGKKVTTLRGPGIAEDFQKMVADYIENRFGLGRKIAS
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: Y375_TREPA
Sequence: MASVFSFLLMSAAGFPTLSTDSSIRSSRNALTLLRWICEAVSAAVPVSRPSANCVTYKAVISKFIARIA
What are the official names of this protein?
Uncharacterized protein TP_0375.
Protein: RL24_IDILO
Sequence: MAAKIKRDDEVVVLAGKDKGKQGKVLKVLTDKDRVIVEGVNVVKKHQKPNPALGESGGIVEQEAAIHISNVAILNPETGKADRVGFRLEDGKKVRFFKSNNAII
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: KATG_SYNY3
Sequence: MGTQPARKLRNRVFPHPHNHRKEKPMANDQVPASKCPVMHGANTTGQNGNLNWWPNALNLDILHQHDRKTNPMDDGFNYAEAFQQLDLAAVKQDLHHLMTDSQSWWPADWGHYGGLMIRMAWHAAGTYRIADGRGGAATGNQRFAPLNSWPDNVNLDKARRLLWPIKKKYGNKLSWGDLIILAGTMAYESMGLKVYGFAGGREDIWHPEKDIYWGAEKEWLASSDHRYGSEDRESLENPLAAVQMGLIYVNPEGVDGHPDPLCTAQDVRTTFARMAMNDEETVALTAGGHTVGKCHGNSKAELIGPEPEGADVVEQGLGWHNQNGKGVGRETMSSGIEGAWTTHPTQWDNGYFYMLFNHEWELKKSPAGAWQWEPVNIKEEDKPVDVEDPNIRHNPIMTDADMAMIKDPIYRQISERFYREPDYFAEVFAKAWFKLTHRDLGPKSRYLGPDVPQEDLIWQDPIPPVDYTLSEGEIKELEQQILASGLTVSELVCTAWDSARTFRSSDYRGGANGARIRLEPQKNWPGNEPTRLAKVLAVLENIQANFAKPVSLADLIVLGGGAAIAKAALDGGIEVNVPFLPGRGDATQAMTDAESFTPLEPIHDGYRNWLKQDYAVSPEELLLERTQLMGLTAPEMTVLIGGMRVLGTNHGGTKHGVFTDRVGVLSNDFFVNLTDMAYQWRPAGNNLYEIGDRQTGEVKWTATKVDLVFGSNSILRSYAEVYAQDDNREKFVRDFVAAWTKVMNADRFDLPRG
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.  Also displays NADH oxidase, isoniazid hydrazine lyase and isonicotinoyl-NAD synthase activities.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RIMM_CLOBH
Sequence: MKEFLAVGEIINTHGIKGEVKVYPLTDDMKRFKKLKEVFIDGEERKILSCKLQPNNVVLKIEGIDSIEEANKYRKKLLEIKRENSVKLPKGSYFIADLIECRVIDEDGREIGQISDVIKTGSNDVYEVKGKSEVLVPAIKDIVTNIDIENKTVTIKPLEIWQCE
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODPB_MOUSE
Sequence: MAVVAGLVRGPLRQASGLLKRRFHRSAPAAVQLTVREAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSAGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVMLENELMYGVAFELPAEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAAAVLSKEGIECEVINLRTIRPMDIEAIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKVLEDNSVPQVKDIIFAVKKTLNI
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, PDHE1-B.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RL7_DESHD
Sequence: MSKTAEILEAVKGLTVLELAELVKAFEEEFGVSAAAPVAVAAAPGAAAAPVAEEQTEFDVVLMNAGAGKINVIKVVREITGLGLKEAKELVDGAPKPVKEKVSKDDAEAIKAKLVEAGATVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: YBA9_SCHPO
Sequence: MGSSSSRRRSSSLVTKVPKPTIDDRLDQGSATNYNSNWVNYKGAWVIHIVLIAALRLIFHAIPSVSRELAWTLTNLTYMAGSFIMFHWVTGTPFEFNGGAYDRLTMWEQLDEGNQYTPARKYLLVLPIILFLMSTHYTHYNGWMFLVNIWALFMVLIPKLPAVHRKRIFGIQKLSLRDDDNDSIPR
What are the official names of this protein?
Uncharacterized protein C119.09c.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RS6_CORDI
Sequence: MRHYEVMIILDPSQDERTVAPSLDKFLEIVRKENGTVEKVDIWGKRRLAYPIAKKEEGIYAVVNLTCESATVLELDRVLNLNDSVMRTKVLRGDK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: YD320_YEAST
Sequence: MRVLHVMLSFLNSLLFLPICFCLLQLKATCAVRVKKYSMKKKKKR
What are the official names of this protein?
Uncharacterized protein YDR320W-B.
Protein: ACSA_NEUCR
Sequence: MSGSTVPAGAVVPEAHTIETFQPPREMLQNHPSKPHLANFEEYQKLYKQSITEPNVFWAERARELLSWSKDFQTVHSGSLANGDNAWFVEGELNASYNCVDRHAHKDPNRVAIIYEADEPGQGRNVTYGELLREVSKLAHVLTNLGVRKGDTVAIYLPMIPEAIVAMLACTRIGAIHSVVFAGFSSDSLRDRVVDAQSKVVITTDEGKRGGKLIGTKKIVDEALQQCPDVRNVLVYKRTGADISMTPGRDLWWHEEVEKYPAYYTPVAMASEDPLFLLYTSGSTGKPKGVAHSTGGYLLGAAMTGKYVFDIHDGDRYFCGGDVGWITGHTYVLYAPLLLGVSTVVFEGTPAYPNFSRYWDIIEEHKVTQFYVAPTALRLLKRAGDHHVRNEMKHLRVLGSVGEPIAAEVWKWYYDVVGKGRAQICDTYWQTETGSNVITPLAGVTPTKPGSASFPFFGIEPALVDPVTGEEIHGNDVEGVLAFKQPWPSMARTVWGAHKRYMETYLHVYKGYYFTGDGAARDHEGFYWIRGRVDDVVNVSGHRLSTAEIEAALIEHHSIAEAAVVGVADELTGQAVNAFVAVKEGTQINDALRKEFVLQVRRSIGPFAAPKAIYIVPDLPKTRSGKIMRRILRKIVAGEEDQLGDITTLSDPSVVAKIIDVVHAQRQ
What are the official names of this protein?
Acetyl-coenzyme A synthetase, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: CITX_VIBCH
Sequence: MSHHPDLSVSLDQLLLRKEVRVRQQGEWLKRHSLPLVSFTVNMPGAVKLNAASQTVMDAGMRAIQELCQKTGWRQVACQLLVEKTGPEAFVVIQAPSASMLKKAMMKIEREHPLGRLMDLDVIDVDGHIISRQGAQLPRRRCLLCERDAVICARSRRHSVEALLAKIEEMTHDYSCCA
What is the function of this protein?
Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.
What are the official names of this protein?
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, Apo-ACP nucleodityltransferase, Holo-ACP synthase, Holo-citrate lyase synthase.
What is the protein family that this protein belongs to?
Belongs to the CitX family.
Protein: BAMS2_PANGI
Sequence: MWRLMTAKGGNDPYLYSTNNFIGRQTWEFDPDYGTPAERAEVEEARLHFWNNRYQVKPSSDVLWRMQFLKEKNFKQIIPQVKVEDGEEITYEAATTTLRRAVHYFSALQADDGHWPAENAGPLFFLPPLVMCLYITGHLNTVFPAEHRIEILRYIYCHQNDDGGWGLHIEGHSTMFCTALSYICMRILGEGRDGGENNACARARKWILDHGSVTAIPSWGKTWLSILGLFDWSGSNPMPPEFWILPPFLPMHPAKMWCYCRMVYMPMSYLYGKRFVGPITPLILQLREELYAQAYDEINWRKVRHNCAKEDLYYPHPLIQDLMWDSLYIFTEPFLTRWPFNKLREKALQTTMKHIHYEDENSRYITIGCVEKVLCMLACWVEDPNGDYFKQHLARIPDYIWVAEDGMKMQSFGSQEWDTGFAIQALLASDLIDEIRPTLMKGHDFIKKSQVKENPSGDFKSMHRHISKGSWTFSDQDHGWQVSDCTAEALKCCLLFSRMPTEIVGDKMEDNQLFDAVNMLLSLQSKNGGLAAWEPAGSSEWLELLNPTEFFEDIVIEHEYVECTSSAIQAMVMFKKLYPGHRKKEIEVSITNAVQYLEDIQMPDGSWYGNWGVCFTYGTWFAMGGLTAAGKTYNNCQTLHKAVDFLIKSQRSDGGWGESYLSCPNKEYTPLEGNRSNLVHTSWAMMGLIHSRQAERDPTPLHRAAKLLINSQMESGDFPQQEITGVFMKNCMLHYAASRNIYPLWALAEYRKNVRLPSKSV
What is the function of this protein?
Component of the oleanane-type triterpene saponins (e. g.  ginsenosides or panaxosides) biosynthetic pathway (PubMed:29378087).  Oxidosqualene cyclase converting oxidosqualene into beta-amyrin, generating five rings and eight asymmetric centers in a single transformation (By similarity).
What are the official names of this protein?
Beta-amyrin synthase 2, Oxidosqualene cyclase 2.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: RS9_ECOLC
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRSELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: CLPP_LARHH
Sequence: MQNVRDWQWSQPAPQALGLVPMVVEQSGRGERAYDIYSRLLKERIVFMVGPVTDETANLVVAQMLFLESENPDKDIHLYINSPGGSVTAGLSIYDTMNFIKPSVSTLCIGQAASMGAFLLSAGAKGKRFALPNSRVMIHQPLGGFQGQASDFEIHAREILTLKRKLNELMAAHCGRPLEDLERDTDRDNFMNAAQALEYGLIDQVLENRAAV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BGLA_ASPOR
Sequence: MKLGWIEVAALAAASVVSAKDDLAYSPPFYPSPWADGQGEWAEVYKRAVDIVSQMTLTEKVNLTTGTGWQLERCVGQTGSVPRLNIPSLCLQDSPLGIRFSDYNSAFPAGVNVAATWDKTLAYLRGQAMGEEFSDKGIDVQLGPAAGPLGAHPDGGRNWEGFSPDPALTGVLFAETIKGIQDAGVIATAKHYIMNEQEHFRQQPEAAGYGFNVSDSLSSNVDDKTMHELYLWPFADAVRAGVGAVMCSYNQINNSYGCENSETLNKLLKAELGFQGFVMSDWTAHHSGVGAALAGLDMSMPGDVTFDSGTSFWGANLTVGVLNGTIPQWRVDDMAVRIMAAYYKVGRDTKYTPPNFSSWTRDEYGFAHNHVSEGAYERVNEFVDVQRDHADLIRRIGAQSTVLLKNKGALPLSRKEKLVALLGEDAGSNSWGANGCDDRGCDNGTLAMAWGSGTANFPYLVTPEQAIQNEVLQGRGNVFAVTDSWALDKIAAAARQASVSLVFVNSDSGEGYLSVDGNEGDRNNITLWKNGDNVVKTAANNCNNTVVIIHSVGPVLIDEWYDHPNVTGILWAGLPGQESGNSIADVLYGRVNPGAKSPFTWGKTRESYGSPLVKDANNGNGAPQSDFTQGVFIDYRHFDKFNETPIYEFGYGLSYTTFELSDLHVQPLNASRYTPTSGMTEAAKNFGEIGDASEYVYPEGLERIHEFIYPWINSTDLKASSDDSNYGWEDSKYIPEGATDGSAQPRLPASGGAGGNPGLYEDLFRVSVKVKNTGNVAGDEVPQLYVSLGGPNEPKVVLRKFERIHLAPSQEAVWTTTLTRRDLANWDVSAQDWTVTPYPKTIYVGNSSRKLPLQASLPKAQ
What is the function of this protein?
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass.  Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
What are the official names of this protein?
Probable beta-glucosidase A, Beta-D-glucoside glucohydrolase A, Cellobiase A, Gentiobiase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HBB0_MOUSE
Sequence: MVHFTAEEKAAITSIWDKVDLEKVGGETLGRLLIVYPWTQRFFDKFGNLSSAQAIMGNPRIKAHGKKVLTSLGLAVKNMDNLKETFAHLSELHCDKLHADPENFKLLGNMLVIVLSSYFGKEFTAEAQAAWQKLVVGVATALSHKYH
What is the function of this protein?
This is a minor early embryonic beta chain.
What are the official names of this protein?
Hemoglobin subunit beta-H0, Beta-H0-globin, Hemoglobin beta-H0 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: QORL1_HUMAN
Sequence: MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF
What are the official names of this protein?
Quinone oxidoreductase-like protein 1, Protein 4P11, Quinone oxidoreductase homolog 1, QOH-1, Zeta-crystallin homolog.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Protein: TSHB_HUMAN
Sequence: MTALFLMSMLFGLTCGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV
What is the function of this protein?
Indispensable for the control of thyroid structure and metabolism.
What are the official names of this protein?
Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, TSH-B, TSH-beta, Thyrotropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPB_ROSDO
Sequence: MTTPMKIAITGVSGRMGRMLVDTIDTSDAVTLSAALERPGHDWIGRDLGLALGGTERGVLVSDDIDSALADSEAVIDFTSPAATIRFAQAAARVGAIHVIGTTGMTEQEIAQIDAQAAGAVIVRAGNMSLGVNLLVQLTKRVAAALDEDFDIEVIESHHNQKVDAPSGTALMLGEAAAEGRGVSLDAVSDRGRDGLTGARQKGDIGFVSVRGGDIVGEHDVLFAAQGERITLRHVASDRSVFARGALKAALWARHRAPGAYDMLDVLGLKDG
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARG33_MOUSE
Sequence: MEKSKAKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELTRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKAQKEEHGAQAGPASAPAPGSAPTQGSPFRSINVPEAGLPSDDFTNMLPSQNYEKAQESRSVHVGDSNVKGMMGPGVNPTTPESDENLKPSLSAEIQSKGHHTPGLWRQPKEGKEWGEEYVTKDHPDKLKDAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNPKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASPNAGQEAVHDSGVHSEEMLQPYPSSSSSAPAVSHLMAPAKKGQQQQSLMESMQPGKPGDWELEGRKHERPESLLAPAQFCAAEQDVKALAGPLQAIPEMDFEPSSAEPLGNVERSLRGPPELLPDARGFVPAGYEEFEYGGEIFALPAPYDEEPFQAPALFDNCSPASSESSLDICFLRPVSFAMEAERPEHALQPLPKSATSPASSSGAYKLEAAQAQAHGKAKPLSRSLKEFPRTPPAEGVAPRLYSTRSSSGGRAPLKVERAPAPHGPAAAAAASRGAPRTFFPQQRSQSEKQTYLEEMHLEDATRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNSTGEDFCGPWGWW
What are the official names of this protein?
Rho guanine nucleotide exchange factor 33.
Protein: MSCL_AZOSB
Sequence: MSFIQEFKEFAMRGNVIDLAVGVIIGGAFGKIVDSLVKDVVMPIVGRLVGGVDFRHLYVNLGSQQYETLEAAEKAGAPLVKYGAFINTTIDFLIIALAIFVAIKAINKLKRSEPPAPAPEPAPEPEDIKLLREIRDALKQR
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAE1_CRYNB
Sequence: MLVLLIVFFNSYYTHCSHHSLYSFHCTPPDPAMKQSPLHRPSRPLLALGIEGSANKLGCGIISHSPSPTGGPTLVMVLSNVRHTYITPPGEGFLPSDTARHHREWVVKVIEEAVRKAGVRMGDLDCIAFTKGPGMGTPLQVGALVARTLSLLHNIPLVGVNHCVGHIEMGRQITSSHNPIVLYVSGGNTQVIAYSQQRYRIFGETLDIAIGNCLDRFARVIGLRNDPSPGYNIEKEAKKGKRLVQLPYGTKGMDVSLAGILHSVEAYTKDKRYRSWDQVNDVEEDIITPYDLCFSLQETTFAMLVEITERAMAHVGAKDVLIVGGVGCNLRLQEMMGIMASERGGRVFATDESFCIDNGIMIAQAGLLAFRMGNTMPLEKTGVTQRYRTDAVHVAWRA
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1, tRNA threonylcarbamoyladenosine biosynthesis protein KAE1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: YIDD_MYCTA
Sequence: MSLSRQSCGRVVRVTGRASARGLIFVIQVYRHMLSPLRPASCRFVPTCSQYAVDALTEYGLLRGSWLTMIRLAKCGPWHRGGWDPIPEGLTTGRSCQTDVDGANDDWNPASKRGERESFV
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CHED_XANCP
Sequence: MSTAVQVDDVMRYRDSRFQTIAAKLLPTQYLVVDDDTALTTTLGSCVAACLRDPVLKIGGMNHFLLPEGQVGDGAPARYGSYAMELLINDMLKRGAHRKRIEAKVFGGANVLKGFTSNPVGTRNAEFVRQYLQAEHIPIIAEDLCGIHPRKVWFFPTTGRVVVQRLPHAHEAEVAAAESAVRARLSKAPVTGGVELFE
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: HSLV_XANAC
Sequence: MDPSQNPNIVHATTIISVRRGGHVAVAGDGQVTLGHTVMKGNARKVRRLGREGQVLAGFAGAAADAFTLFELFEAKLDKHGQLTRAAVELAKDWRTERRLGKLEALLAVADKETSLIISGTGDVVEPEDGIIAIGSGGSYALSAARALLAHTQLDAKTIAAEAINIAGDICIYTNRNVVVEEL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF79_ASFM2
Sequence: MNKTIEYQKEFLKENNQLLNIPVKKSILKEILQNNEQDTIITNCITKEVSINLDLIKNPKVLYSIYNLVVEYLKSMNIA
What are the official names of this protein?
Uncharacterized protein D79L, pD79L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus D79L family.
Protein: TCPC_ECOL6
Sequence: MIAYENIEFFICLVNVLGNNMYNILFFIFLSIAIPFLLFLAWKQHLKTKEIRSYLLKEGYNIIFNGEGNSYLAFNISNATFRAGNLTSNDYFQASISYIHDYRWEWKEVEAKKINNIFIIYISNIDFPSQKLFYRNNKSLAEIDWAKLQAIFHQPYEIQNDVMQDNNNTHYDFFISHAKEDKDTFVRPLVDELNRLGVIIWYDEQTLEVGDSLRRNIDLGLRKANYGIVILSHNFLNKKWTQYELDSLINRAVYDDNKIILPIWHNINAQEVSKYSHYLADKMALQTSLYSVKEIARELAEIAYRRR
What is the function of this protein?
Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection, thereby increasing bacterial burden in the urinary tract and promoting renal tissue damage (PubMed:18327267, PubMed:20886104).  Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922).  Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922).
What are the official names of this protein?
NAD(+) hydrolase TcpC, NADP(+) hydrolase TcpC, TIR domain-containing protein in E.coli, tcpC.
What are the subcellular locations of this protein?
Secreted. Membrane; Single-pass membrane protein.
Protein: RL15_BURP6
Sequence: MELNNLKPAEGAKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFTSLTKEFVGEVRLGDLEKLPVDEIDLLALKQAGLVGELIKSAKIIATGELKRKIVVKGLGATKGARAAIEAAGGSFAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PURA_THEVO
Sequence: MSVNYSEDNNRTAVVVGLQFGDEGKGKITDFLSESYDVVVRFNGGTNAGHTVVVGNETYKFHLLPSGSLRTKVVVLGSGMVIDPQSLISEIEIVKKNNSNLAVVVSSNAHVVTKIHKYLDVEEEKIRSSMVIGTTAQGIGPTYEDKYARSGLRMIDLLDYKTIIEKLDIIYRMHENLLSRSEFSDPSVRENLAKELYSYGQELKKYMYYTDILINKLYNEGRTILFEGAQGVLLDPDFGFYPYVTSSNTISASSYTGTGFSMRKIKKVIGVAKAYVSKVGAGPFPTELNDDLAKKIRDAGGEYGTTTGRPRRVGWLDVPLLKYAVQIDDVDEIALTKVDTLGILHTIKVCYSYELDGKQIDYIPKHISEVSRVKPLYEEFEGWGDLSSSLLHPKMRKWEIPQQLRRYIDFIEEQIGRPVTIISSGKDRSKTVRIER
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARP5L_HUMAN
Sequence: MARNTLSSRFRRVDIDEFDENKFVDEQEEAAAAAAEPGPDPSEVDGLLRQGDMLRAFHAALRNSPVNTKNQAVKERAQGVVLKVLTNFKSSEIEQAVQSLDRNGVDLLMKYIYKGFEKPTENSSAVLLQWHEKALAVGGLGSIIRVLTARKTV
What is the function of this protein?
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 5-like protein, Arp2/3 complex 16 kDa subunit 2, ARC16-2.
What is the protein family that this protein belongs to?
Belongs to the ARPC5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.