PharMolix/UniProtQA huggingface dataset:
Protein: RL15_ACIBS
Sequence: MTLRLNELAPAEGAKREHRRLGRGIGSGVGKTGGRGIKGQKSRKSGGVRPGFEGGQTAIYRRLPKFGFTSQIALKTAEVRLSELSKVEGDIVSLETLKAANVVRRDQIRARIVLSGEITRAFTVQGVALTKGAKAAIEAAGGKVEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PEPX_STRA3
Sequence: MRYNQFSYIPTKPNEAFEELKGLGFPLNKKNSDKANLEAFLRHSFLNQTDTDYALSLLIVDAKTDALTFFKSNSDLTLENLQWIYLQLLGFVPFVDFKDPKAFLQDINFPVSYDNIFQSLHHLLACRGKSGNTLIDQLVADGLLHADNHYHFFNGKSLATFNTNQLIREVVYVEISLDTMSSGEHDLVKVNIIRPTTEHTIPTMMTASPYHQGINDPAADQKTYQMEGALAVKQPKHIQVDTKPFKEEVKHPSKLPISPATESFTHIDSYSLNDYFLSRGFANIYVSGVGTAGSTGFMTSGDYQQIQSFKAVIDWLNGKVTAFTSHKRDKQVKADWSNGLVATTGKSYLGTMSTGLATTGVEGLKVIIAEAAISTWYDYYRENGLVCSPGGYPGEDLDVLTELTYSRNLLAGDYIKNNDCYQALLNEQSKAIDRQSGDYNQYWHDRNYLTHVNNVKSRVVYTHGLQDWNVKPRHVYKVFNALPQTIKKHLFLHQGQHVYMHNWQSIDFRESMNALLSQELLGIDNHFQLEEVIWQDNTTEQTWQVLDAFGGNHQEQIGLGDSKKLIDNHYDKEAFDTYCKDFNVFKNDLFKGNNKTNQITINLPLKKNYLLNGQCKLHLRVKTSDKKAILSAQILDYGPKKRFKDTPTIKFLNSLDNGKNFAREALRELPFTKDHYRVISKGVLNLQNRTDLLTIEAIEPEQWFDIEFSLQPSIYQLSKGDNLRIILYTTDFEHTIRDNASYSITVDLSQSYLTIPTNQGN
What is the function of this protein?
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Xaa-Pro dipeptidyl-peptidase, X-Pro dipeptidyl-peptidase, X-prolyl-dipeptidyl aminopeptidase, X-PDAP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S15 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANB_XANC8
Sequence: MSSHADSKPWTVPALAQAKRDGRKLVMLTAYDAGFARTFDANGVDLILVGDSLGMVVQGHESTLPVTTADMVYHTAAVARVLERALLVADLSFQADATPERALDAATQLLQAGAEMVKIEGAGHKLDVIRYLVEREIPVCSHLGLTPQSVLRFGGYKVQGRGEAGEQLRRDAQAAVDAGASLIVLECVPTPIAAQISAELRVPTIGIGAGPGCDGQVLVMHDMLGLDSGHRRPKFVKDFLAEGGSVAGAVQAYAQAVRDGSFPDAEHAYAA
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_SHEAM
Sequence: MPKMKTDRGVAKRFKKTANGFKRKQAHLRHILTKKSTKRKRHLRAKCLVAKVDVPAIARQLPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: RS11_SALA4
Sequence: MAKAPVRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: FXL17_MOUSE
Sequence: MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRALAKASPQPAAPRSRDCFFRGPCMLCFIVHSPGAPASAGLEEEPPLSPPPPPPRDGAYAAVSSQHLARRYAALAAEDCAAAARRFLLSSAAAAAAAASSPASCCKELGLAAAAAWEQQGRSLFLAGVGPVRFLGPLAAVQLFRAPPAPPPQAEPATALEMVCKRKGAGVPACTPCKQPRCGCGGCGGGGGGGGGPAGGGASPPRPPDAGCCQAPEQPPPPLCPAPASPASECAPIVAAAGDTVRAGGTAPSSAQQQPESGDADCQEPPENPCDCHREPPPEIPDINQLPPSILLKIFSNLSLNERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSLSDSGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSRCRELKDIHFGQCYKISDEGMIVIAKSCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSVTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNELTVEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAATS
What is the function of this protein?
Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC).  FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (By similarity).  The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity).  The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (By similarity).  The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed:27234298).  The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (PubMed:28883095).
What are the official names of this protein?
F-box/LRR-repeat protein 17, F-box and leucine-rich repeat protein 17, F-box only protein 13.
What is the protein family that this protein belongs to?
Belongs to the FBXL17 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Present in the cytoplasm and nucleus; more abundant in the cytoplasm.
Protein: BIOF_METPB
Sequence: MAPNLSPNPSNSLDAFAAEKLAGLEAAALRRRLAVTARGPEAAAERGGRRLVSFSCNDYLGLAHDPRVIAAASDALRRYGAGAGASRLVTGNSPPLAALEERLARHKGKEAALVFGSGYLANLGIAPALVGQGDLILIDDLGHSCLFAGARMSGALTLRFTHNDVAQLRALLAEQRGAARRALILTERVFSMDGDRAPLAEILALAGAYDAWTLVDDAHGLGVVEPGQRAPLEMGTLSKTLGSYGGYLCASRAVIDLLTSRARSLVYTTGLPPASAAAALKALEIVEAEPEHAARPLMLARRFTARLGLPEATSPIVPVLVGAAESALALSAALEARGFLVVAIRPPTVAPGTARLRVAFSAAHDAAQVDALAEALAELAPDSLRAA
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase, Alpha-oxoamine synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: PUR9_ALCBS
Sequence: MSNVERALISVSDKTGIVEFAQALADKGVELLSTGGTFKKLQEAGIAVREVSDYTGFPEMMAGRVKTLHPKVHGGILGRRGQDEQVMADNDISPIDLVVVNLYPFEATVANPDCSLEDAIENIDIGGPTMVRSAAKNNASVGIVTDAADYQRVLDDMAANNGALSDDLRFDLAIKAFEHTAAYDSAIANYFGKKVEGQDGMSNLDFPRTINLNFEKTQNMRYGENPHQKAAFYTERNPAPASIATAKQLQGKELSYNNIADTDAALECVKGFTKPACVIVKHANPCGVAVSLDGITTAYDLAFATDTESAFGGIIAFNRKLDAATAQAIVDRQFVEVIIAPSATEEALAITAAKKNVRVLVCGEMEGVAASGLDYKRVNGGLLVQDRDLGMITEGELKVVTKRAPTEAEMHDLIFAWKVAKFVKSNAIVYAKDRQTVGVGAGQMSRVNSARIAAIKAEHAGLQVKGSVMASDAFFPFRDGIDNAAKVGISCVIQPGGSIRDEEVIAAADEAGMAMVFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: THIK_ECO5E
Sequence: MPFRSNNPITRDELLSRFFPQFHPVTTFNSGLSGGSFLIEHQGQRFVVRQPHDPDAPQSAFLHQYRALSQLPACIAPKPHLYLRDWMVVDYLPGEVKTYLPDTNELAGLLYYLHQQPRFGWRITLLPLLELYWQQSDPARRTVGWLRMLKRLRKAREPRPLRLSPLHMDVHAGNLVHSASGLKLIDWEYAGDGDIALELAAVWVENTEQHRQLVNDYATRAKIYPAQLWRQVRRWFPWLLMLKAGWFEYRWRQTGDQQFIRLADDTWRQLLIKQ
What is the function of this protein?
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
What are the official names of this protein?
Thiamine kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine kinase family.
Protein: DAPB_AGRRK
Sequence: MSDDAMKLVVVGAAGRMGQALIRLIHATEGLTLHAAVARPGSAFIGKDAGEIAGLGQIGIPVTDDPLSAFLHADGVIDFTTPATSVTFADLAAQARIVHVIGTTGCSAEDETRFKAAARHARIVKSGNMGLGINLLSVLVEQAARALPPADWDIEVLEMHHKHKVDAPSGTALLLGEAAAKGRGIDLGDHSVRVRDGYTGPRPAGSIGFATLRGGAVIGDHSVIFAGEGERLTLSHSAGDRSLFARGALQAALWARDKKPGLYSMLDVLGLSTR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BL1S5_CHICK
Sequence: MSGAGPASPGRSGSALPLPLPLSLSLTGDRKREVPAAGTLLQPIIKDVGEIYSRLLDHRPVIQGEIRYFVKEFEEKRGLRELRVLENLKKTIFETNEDILPKCKQSMHDNLNEVLQRLQAANDTIHKLQEKEHEKRKIQADKLMAGEEKRIAQQETFLQEQQSKREEVDEEHRKAMERLKEQYSEMEKELAKYVSF
What is the function of this protein?
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes.  Plays a role in intracellular vesicle trafficking (By similarity).
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S5 family.
Protein: RBOHD_SOLTU
Sequence: MQNPEDHHSDRELSSPSNTTKSNDDKNVEITLDIRDDTMAGQSVKNATKTKAEEAELEALGKNLQKKCSFGATIVRNVSMRMRLPSFKRQPHPPQTFDRSSTAAQNALKGFKFISKTDGGSGWDTVQQRFDELTATSDSLLPRAKFGECIGMNRESEGFALELFNALARRRNITSGCISKEQLKEFWDQIANQSFDSRLRTFFDMVDKDADGRLTEEEVREIICLSASANKLSNIQKQAAEYAALIMEELDRDQKGYIMLENLEMLLLEAPIQPDGEKGLNRNLSHMLSMKLKPTLETNPIKRWYNNLKYFLLDNWRRVWVLLLWIGVMAGLFAYKYVQYKNKAAFNVMGHCVCVAKGAAEVLKLNMALILLPVCRNTITWLRNKTKLGGAVPFDDNINFHKVVAGAIAVGVGIHVLAHMTCDFPRLLNASPEKYKPMEPYFGDQPRNYWHFVKGVEGVSGIIMVVLMSIAFTLASQRFRRNKIRLPRPLNKLTGFNAFWYSHHLFVIVYSLLIVHGIELYLTKEWYKKTTWMYLAIPIILYSGERLLRAFRSSVKDVKILKVAMYTGNVLTLQMSKPQGFNYKSGQYMFVNCAAVSPFEWHPFSITSAPGDEYLSVHIRIVGDWTTKLRDVFSEPSPTGRSGLVADYLQDKINYPKVLIDGPYGAPAQDYKEYEVLLLVGLGIGATPMISIVKDIVNNMKEEKYDHDLEKKTVSGSGRSNFKRVYFYWVTREQGSFDWFKGLMNELAVMDCDGIIEMHNYCTSVYEEGDARSALIAMLQSINHAKNGVDIVSGTRVKTHFARPNWRNVYKRIALNHTDARVGVFYCGAPALTKVLGQLALDFSHKTSTKFDFHKENF
What is the function of this protein?
Calcium-dependent NADPH oxidase that generates superoxide.  May be responsible for the oxidative burst in response to pathogen attack in the leaves.
What are the official names of this protein?
Respiratory burst oxidase homolog protein D, NADPH oxidase RBOHD, StRBOHD.
What is the protein family that this protein belongs to?
Belongs to the RBOH (TC 5.B.1.3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ACCA_YERPG
Sequence: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINLDEEVQRLREKSVELTRKIFSDLGAWQIAQLARHPRRPYTLDYIANIFTDFEELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMEMAERFKLPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLNVPIVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGITAHRLKELKMIDSVIPEPLGGAHRDYAAIAISLKAQLLADLNDLDVLNDEELLNRRYQRLMNYGYC
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3915_XANAC
Sequence: MHIHDWPTHERPREKLLARGATALSDAELLAILVGSGLRGQDAVQTARDLLHRHGPLRLLLDRPAKALTRLPGLGPASACKFAAAMELAQRHLMSALERGEALSDPPSVGRYFSQRLRARAYEVFAVLFLDNRHRAIAFEELFTGTIDGADIHPREVVRRALLHNAAAVIVGHNHPSGNPEPSEADRAVTKRLLDSLELVDIRLLDHFVIGDGRPVSFAERGWLE
What are the official names of this protein?
UPF0758 protein XAC3915.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: IOLC_LISMF
Sequence: MNLNKHSERKFDLITVGRACIDLNAVEYNRPMEETMTFSKYVGGSPANIAIGTAKLGLKVGFIGKISADQHGRFIEKYMRDLSINTDGMVKDTEGRKVGLAFTEIKSPDECSILMYRENVADLYLTPEEISEDYIKEARVLLISGTALAQSPSREAVLKAVSLARKNDVAVAFELDYRPYTWTNTEETAVYYSLVAEQADVIIGTRDEFDMMENQVGGKNEATKAHLFQHQAEIVVIKHGVEGSFAYTKAGETFQAKAYKTKVLKTFGAGDSYASAFLYGLFSGESIETALKYGSAAASIVVSKHSSSDAMPTADEIKALIAQAE
What is the function of this protein?
Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).
What are the official names of this protein?
5-dehydro-2-deoxygluconokinase, 2-deoxy-5-keto-D-gluconate kinase, DKG kinase.
What is the protein family that this protein belongs to?
Belongs to the carbohydrate kinase PfkB family.
Protein: LEUTX_HUMAN
Sequence: MFEGPRRYRRPRTRFLSKQLTALRELLEKTMHPSLATMGKLASKLQLDLSVVKIWFKNQRAKWKRQQRQQMQTRPSLGPANQTTSVKKEETPSAITTANIRPVSPGISDANDHDLREPSGIKNPGGASASARVSSWDSQSYDIEQICLGASNPPWASTLFEIDEFVKIYDLPGEDDTSSLNQYLFPVCLEYDQLQSSV
What is the function of this protein?
Inactive transcriptional activity.
What are the official names of this protein?
Paired-like homeodomain transcription factor LEUTX, Leucine-twenty homeobox, Paired-like homeobox transcription factor LEUTX, PRD-LIKE homeobox transcription factor LEUTX.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HRH2_MOUSE
Sequence: MEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
What is the function of this protein?
The H2 subclass of histamine receptors mediates gastric acid secretion.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
What are the official names of this protein?
Histamine H2 receptor, H2R, HH2R, Gastric receptor I.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FBID_MYCTK
Sequence: MSGTPDDGDIGLIIAVKRLAAAKTRLAPVFSAQTRENVVLAMLVDTLTAAAGVGSLRSITVITPDEAAAAAAAGLGADVLADPTPEDDPDPLNTAITAAERVVAEGASNIVVLQGDLPALQTQELAEAISAARHHRRSFVADRLGTGTAVLCAFGTALHPRFGPDSSARHRRSGAVELTGAWPGLRCDVDTPADLTAARQLGVGPATARAVAHR
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
Phosphoenolpyruvate guanylyltransferase, PEP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: INSL_VIGUN
Sequence: FVNQHLXGSHLVEALYLVXGERGFFYTPKAGIVEQXXASVXSLYQLENYXN
What is the function of this protein?
May be involved in the transport of sugars to the developing embryo in the fruit.  May also be involved in signaling events.
What are the official names of this protein?
Insulin-like protein.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
Protein: SYP_ZYMMA
Sequence: MRLSRYFLPVMKETPADAQIISHKLMLRAGMIRQTAAGIYAWLPLGLRVLRRIEKIIREEQARAGALELLMPTLQTADLWRESGRYDAYGPEMLRIKDRHNRELLYGPTNEEMITALIRDNLQSYRDLPRIFYHIQWKFRDEVRPRFGVMRGREFLMKDAYSFDIDETAGRHNYNRMFVAYLNSFSRLGLRAIPMQADTGPIGGDLSHEFIVLAPNGESDVFYHSNWEQPTRHIEADFDDPKALQSIVNDHISDYAATDEKRDPLREAQAGDKLRQSRGIEVGHIFFFGTKYSKPMGFTLPGPDGKPIPIQMGSYGIGISRLLGAIIEASHDDNGIIWPEAVAPYHVGLINLRIDDENCRAIADSLYQRLEAAGIDTLYDDRNERGGAKFATMDLIGLPWQVVIGPKGAEKGVVELKNRASGEKQTISVEDAFNLLTAGHQQR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSDE_MOUSE
Sequence: MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.  The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex.  Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation.  Also involved in homologous recombination repair by promoting RAD51 loading.
What are the official names of this protein?
26S proteasome non-ATPase regulatory subunit 14, 26S proteasome regulatory subunit RPN11, MAD1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. PSMD14 subfamily.
Protein: TCTP_KLULA
Sequence: MIIYTDIISGDELLSDAYDLKLVDGVIYEADCDMVKVGGDNIDIGANPSAEDGGDDVEDGTELVNNVVHSFRLQQTAFDKKSFLTYIKGYMKEIKGRLQESNPDEVSVFEKGAQAYVKKVIGSFKDWEFFTGESMDPDGMLVLLNYREDGTTPFVAIWKHGVKAEKI
What is the function of this protein?
Involved in protein synthesis.  Involved in microtubule stabilization (By similarity).
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: TACY_STRP3
Sequence: MSNKKTFKKYSRVAGLLTAALIIGNLVTANAESNKQNTASTETTTTNEQPKPESSELTTEKAGQKTDDMLNSNDMIKLAPKEMPLESAEKEEKKSEDKKKSEEDHTEEINDKIYSLNYNELEVLAKNGETIENFVPKEGVKKADKFIVIERKKKNINTTPVDISIIDSVTDRTYPAALQLANKGFTENKPDAVVTKRNPQKIHIDLPGMGDKATVEVNDPTYANVSTAIDNLVNQWHDNYSGGNTLPARTQYTESMVYSKSQIEAALNVNSKILDGTLGIDFKSISKGEKKVMIAAYKQIFYTVSANLPNNPADVFDKSVTFKELQRKGVSNEAPPLFVSNVAYGRTVFVKLETSSKSNDVEAAFSAALKGTDVKTNGKYSDILENSSFTAVVLGGDAAEHNKVVTKDFDVIRNVIKDNATFSRKNPAYPISYTSVFLKNNKIAGVNNRTEYVETTSTEYTSGKINLSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNWYSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVKLSKEINVNISGSTLSPYGSITYK
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Streptolysin O, SLO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein. Note=Probably secreted as soluble protein by the accessory Sec system (By similarity). It then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands (By similarity).
Protein: APAG_XYLFA
Sequence: MENNPSSKIEVAISSRFLDHQSNRNEGRYVFAYTIRIYNAGNVPARLIARHWQITDANGKVEYVTGEGVIGEQPRLRPGEEFRYTSGVVLGTEQGQMQGHYDMMADDGTEFTATIAPFVLSVPRTLH
What are the official names of this protein?
Protein ApaG.
Protein: ARO1_NEUCR
Sequence: MAEPISNPTRINILGKDNIIIDHGIWLNFVAQDLLQNIKSSTYILITDTNLYKTYVPPFQSVFEKAAPQDVRLLTYAIPPGEYSKGRDTKAEIEDWMLSHQCTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQCPTTLLAMVDSSIGGKTAIDVPMGKNLIGAFWQPERIYIDLTFLNTLPVREFINGMAEVIKTAAIWDENEFTALEENAKAILEAVRSKNKSADRLAPIRDILKRIVLGSARVKAEVVSSDEREGGLRNLLNFGHSIGHAYEAILTPQVLHGEAVAIGMVKEAELARFLGVLRPSAVARLSKCIASYDLPTSLQDKRIVKLTAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEPKASVVEDRAIRIVLSPCIRVFAGVPKDLNVSVTPPGSKSISNRALILAALGEGTTRIHNLLHSDDTQVMLNAVAQLQGASFSWEEGDVLVVKGNGGKLQATSTPLYLGNAGTASRFLTSVAALCNPSDVNSTVLTGNARMKQRPIGALVDALRANGVGVKYLEKEHSLPVQVDAAGGLAGGVMELAATISSQYVSSLLMAAPYAREPVTLRLVGGKPISQPYIDMTIAMMASFGVQVQRSAEDPNTYYIPQGTYKNPETYVVESDASSATYPLAIAAITGTTCTVPNIGSKSLQGDARFAIEVLRPMGCTVEQTDVSTTVTGPPIGTLKAIPHVDMEPMTDAFLTASVLAAVASGTTQITGIANQRVKECNRILAMKDQLAKFGVHCNELEDGIEVIGIPYTELKNPTEGIYCYDDHRVAMSFSVLSTISPHPVLILERECTGKTWPGWWDTMSNYFKVHLEGEEEPHSSHVSHEKPRKGNPKSIFIIGMRGAGKSTAGKWMSEVLNRPLIDLDHELERREGQTIPEIIRSERGWEGFRKAELELLEDVIKNNPTGHIFSCGGGIVETEAARKMLLSYSQNGGIVLLVHRDTDQVVEYLMRDKSRPAYSENIREVYYRRKPFFEECSNFRYYSPHPDGSKALTEPPFDFSQFLSVICGHSNHLEEVKKKPHSFFVSLTVPNVSKALDIIPKVVVGSDAVELRVDLLEDYDPEFVAKQVALLRSAARIPIVYTVRTVSQGGKFPDDDYELALKLYRTGLQAGVEYLDLEMTMPDEVIEAVTNEKGYTHIIASHHDPKATLSWKNGGWIQYYNKALQHGDVVKLVGVARELADNFALARFKASLAAAHDKPLIALNMGAAGKLSRVLNGFLTPVSHPALPSKAAPGQLSAAEIRQALALIGELEPRSFHLFGNPISASRSPALHNALFRDNGLPHQYSLFETDNAADVKDLIRAPGFGGASVTIPLKLDIMPLLDEVSDAAKVIGAVNTIIPVRNGDKVTLRGDNTDWMGMVYALRNAGVVKCTKESPTAGMVVGAGGTTRAAVHALHDLGFAPIYVVARNADRVKALAESFPAEYDIRSLSTPEEVAAESTAQPSVVISTIPADKPIDQSMREVIVASLRHPSVADGKHVLLEMAYTPRHTPLMQLAEDAHWQTIPGLEVLAAQGWYQFQLWTGITPIYTDAQAAVMGN
What is the function of this protein?
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
What are the official names of this protein?
Pentafunctional AROM polypeptide.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the shikimate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCRI_CERSP
Sequence: MSNAEDHAGTRRDFLYYATAGAGAVATGAAVWPLINQMNPSADVQALASIFVDVSSVEPGVQLTVKFLGKPIFIRRRTEADIELGRSVQLGQLVDTNARNANIDAGAEATDQNRTLDEAGEWLVMWGVCTHLGCVPIGGVSGDFGGWFCPCHGSHYDSAGRIRKGPAPENLPIPLAKFIDETTIQLG
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
What are the official names of this protein?
Ubiquinol-cytochrome c reductase iron-sulfur subunit, Rieske iron-sulfur protein, RISP.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: YIDD_GEOSW
Sequence: MKKLLISFIRFYQIFISPLKPPTCRFYPTCSHYGLEAVKRFGAIKGGWLTIKRILKCHPFHPGGFDPVPEKQENGKS
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.