PharMolix/UniProtQA huggingface dataset:
Protein: PBN1_EMENI
Sequence: MRQRITYIQKPSLPFHPSQTTLTRDSLYVESLDAAREERVTFSFDELPSELWQVLRQCHQLHIRWASERAFEAVSPLSSRISPGLHVFYSPVEAGRAKRDSEGREPLCTLLKKVFDDELRCESPEKSFITPPILSKRFASTTAYQFYELLPSLGNLVTYIQQKFCGTDDKCHQRAASILSADSVDINYDSISHALTMSGFWSQAPGEQGWTETIGKHEGGTDKVEIGLLGAEPASEPEEIKVGGLLAVVGQDEELKPTLFSFPSRHHPLHEDATYSVTFPPPTGLHPTMTISIAPEALKEPPRRPDATCALHAYLTLPSKLFGDKYQLSTTDPLFLKSHNLASLRAVAGETDLEAPDWSISRWGSNWLLELASPSESDEVAEEWNITIPLHLRYLPPSESGYQPASVPWPVVFWACSAEDGTKMGVNPFDRINLGWEGLFGPRTMFYQLHPSPSPEGGNLVEELEVPVLTLKENSGIFNSQVIELGTFAVISIGFLWVLWKLGLVARSSGIRPQHQRNPGKRDKAE
What is the function of this protein?
Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum.  Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis.  Probably acts by stabilizing the mannosyltransferase gpi14 (By similarity).
What are the official names of this protein?
Protein pbn1.
What is the protein family that this protein belongs to?
Belongs to the PIGX family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Protein: RS4_SHEON
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDSKCKLESAPGQHGARKPRLSEYGLQLREKQKVRRIYGVLEKQFRNYYKEAARLKGNTGENLLQLLETRLDNVVYRMGFGATRAESRQLVSHKSVMVNGRVVNIPSFKVSANDVVSIREKSRTQARIKAALEVAAQREKPTWVEVDSAKMEGAFKRIPERSDLSAEINEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: EFTU2_YERPE
Sequence: MSKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAFDQIDNAPEEKARGITINTSHVEYDTPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMVDDEELLELVEMEVRELLSQYDFPGDDTPVIRGSALKALEGDAEWEAKIIELAEALDSYIPQPERAIDRPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIIDTIKTTCTGVEMFRKLLDEGRAGENVGVLLRGTKRDDVQRGQVLAKPGSIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNVNMVVNLIAPIAMDDGLRFAIREGGRTVGAGVVAKVIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu-B, EF-Tu-B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIK_SHISS
Sequence: MPFRSNNPITRDELLSRFFPQFHPVTTFNSGLSGGSFLIEHQGQRFVVRQPHDPDAPQSAFLRQYRALSQLPASIAPKPHLYLRDWMVVDYLPGAVKTYLPDTNELAGLLYYLHQQPRFGWRITLLPLLELYWQQSDPARRTVGWLRMLKRLRKAREPRPLRLSPLHMDVHAGNLVHSASGLKLIDWEYAGDGDIALELAAVWVENTEQHRQLVNDYATRAKIYPAQLWRQVRRWFPWLLMLKAGWFEYRWRQIGDQQFIRLADDTWRQLLIKQ
What is the function of this protein?
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
What are the official names of this protein?
Thiamine kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine kinase family.
Protein: LIFO_ACIAD
Sequence: MNGSKKIYLGIGLVALLMIFIYWLMPKDTANASSQIESTNASAIIATSPGQQNQLSENTTPFGSVSQHDTQVNCQLQLNAANHLIVNEQTRNCFEYFLTQYGEKSLTQIDQDIKNYFTQSLPQPARDQAQDLWQRYLKYREELGNLKEPAIAKTDIAYYRAVFTSRQMLRQRFFSATEIAGLFGSEDIYNQYTLERMAILNNSKLSEIEKAKQLKALFDQLPQDWKANLEQLSKLDDLKQLTTSIKKNGGSAQELHDMRTNLVGHDATARLEQLDVERSNWKSNVTQYLDERQTILNSNMSDTAKQNAISALRSKNFTAPQDQIRVQAFESAKDQGQSLPFSE
What is the function of this protein?
May be involved in the folding of the extracellular lipase during its passage through the periplasm.
What are the official names of this protein?
Lipase chaperone, Lipase activator protein, Lipase foldase, Lipase helper protein, Lipase modulator.
What is the protein family that this protein belongs to?
Belongs to the lipase chaperone family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: RBFA_LISMC
Sequence: MNVRANRVSEQMKKELGDILNRKIKDPRLGFVTVTGVDVTGDLQEAKVFISILGTDKEKENTLLALAKAHGFIRSEIGRRIRLRKVPEMSFEIDNSIAYGNRIDELLRDLNNDQ
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_THERP
Sequence: MLMPRRVQHRKQHRYRTKGIAWRGSTLAFGDYGIQALEPAWVTAQQIEAARRAITNAVRRGGKVWIRVFPDKPVTKKPAETRMGSGKGNPEYWMDVVKPGRILFELAGVREELALEALTRAIHKLPCRCRIVKRERPGEAAEEEAS
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RR4_PINKO
Sequence: MSRYRGPRLKIIRRLKTLPGLTSKRPKNRKDSMNMNRSSSRKISQYRIRLEEKQKLRFHYGLTERQLLKYVRVSRRAKGSTGQVLLQLLEMRLDNIIFRLGMAPTIPGARQLVNHGHIRVNDHMVDIPSYPCKPQDVITIRDQPRLRAIIKKNIDLFQRDKLPNHLTFHPLQYKGFINQIIDSKWISLKINELLVVEYYSRQA
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL21_CARHZ
Sequence: MYAIIQTGGKQYKVAEGDKIFVEKLNAEPGSIVTINEVLAVVKDGSIKAGNPYVEGAKVNLKVVRHGKGRKIIVFKYKPKKNYRRKYGHRQPFTEVIVEKIEA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: ATP8_RHISA
Sequence: MPQIFPMNWFLMSLMIMMILIFMTINFYFFSMKMPNKNMFNLNKKTKYNFKW
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: KITH_VACCT
Sequence: MNGGHIQLMIGPMFSGKSTELIRRVRRYQIAQYKCVTIKYSNDNRYGTGLWTHDKNNFEALEATKLCDVLESITDFSVIGIDEGQFFPDIVEFCERMANEGKIVIVAALDGTFQRKPFNNILNLIPLSEMVVKLTAVCMKCFKEASFSKRLGEETEIEIIGGNDMYQSVCRKCYIDS
What is the function of this protein?
Phosphorylates thymidine and thymidine analogs, such as azidothymidine (AZT).  Part of the salvage pathway for pyrimidine deoxyribonucleotide synthesis.
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
Protein: YCNC_BACSU
Sequence: MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLFQSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNMLTYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFLMLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKSVLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQTGVLTQPVSMLKTLLIT
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YcnC.
Protein: ARNC_ECOSE
Sequence: MFEIHPVKKVSVVIPVYNEQESLPELIRRTTTACESLGKEYEILLIDDGSSDNSAHMLVEASQAENSHIVSILLNRNYGQHSAIMAGFSHVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQNRQDSWFRKTASKMINRLIQRTTGKAMGDYGCMLRAYRRHIVDAMLHCHERSTFIPILANIFARRAIEIPVHHAEREFGESKYSFMRLINLMYDLVTCLTTTPLRMLSLLGSIIAIGGFSIAVLLVILRLTFGPQWAAEGVFMLFAVLFTFIGAQFIGMGLLGEYIGRIYTDVRARPRYFVQQVIRPSSKENE
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBN2_MOUSE
Sequence: MAEPRRVAFISLSPVRRREADFAGAEREPPRLEPQPYREPARAEPAPRADAQPPARDKPLPQREVSRAEPPMALQREPPRPEPPPPPLPLQTPPPRESASRAEPPPRPPKETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLVHTEDPFTDEHKERQEVEMLAKKFEMKYGGKARKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDFTDNQKHKPPKVPKIKEDDIEVKKRKRKEEGEKEKKPRKKVPKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESTPKVPVTPSSSSLPKPPCVTTALGDDIPDLGLNSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDATSDGSPLSESGGENGNTTHPTFPSQVVPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQADEEREKNGSDDDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPASKPKVKECSPKKDPKAPASVVASGGGPSTSSSTSIVASASSSSAPAQETICLDDSLDEDLSFPSASLDLVSEALAVINNGNKGPSVGSRLNVPTTKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSQAQAAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSQLLKTSDKPLMYRLPLSTPSPGNGSQGPHPLVSRTAPSTTTSSNYLAKAMVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLPSPKPSVSPKPSLSAKPSISTKQISKSNPAPKPAVCPSSSSPNTLVAQSSHSTSNNPVHKQPSGMNISRQSPTLNLLPSNRTSGLPTTKTLQAPSKLTNSSSTGTAGKNSLSGIPMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPTSASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQTVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTATSGSTSAALHHSLTQNLLKSLQPGAQHAAALPHSPLPAHLQQAFNDGGQSKGDTKLPRKPQ
What are the official names of this protein?
Ubinuclein-2.
What is the protein family that this protein belongs to?
Belongs to the ubinuclein family.
Protein: END4_BUCAI
Sequence: MNYIGAHVSSSGGLEKTVLRAIQIKATAFSFFTKNQRQWFSPPLIQKKIDQFKAMCIKYSFQPQQILPHSSYLINLGHPIDELLRKSRKSFIDEMIRCSQLGLIFLNFHPGSHLNKITENACLLRVSDSINIALEKTQNVIAVIENTAGQGTNIGYCFEHLSEIIKNIDDKSRVGVCIDTCHLFASGYDLRTKKDCENTFEKFNSLIGLKYLKGIHLNDSKKKINSRVDRHESLGLGEIGTAAFTWIIKNENFSNIPIILETANPMIWEEEIDWLRSQKKL
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: JMJD6_CHICK
Sequence: MNHKSKKRIREAKRSARPELKDSLDWTRHNYCETFPLSPAACKDNVERADALQLTVEEFVERYEKPYKPVVLLNAQVGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMETTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVAREEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASCTNFPVVWHKTVRGRPKLSRKWYRILKQEHPDLAALADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSECDSGSETEGMMHRRKKRRTCSMMGNGDTTSQDDCVSKERSSSRIRESCGGRSYP
What is the function of this protein?
Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase.  Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2.  Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65.  Hydroxylates its own N-terminus, which is required for homooligomerization.  In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA.  Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation.  Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code.  However, histone arginine demethylation may not constitute the primary activity in vivo.  In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes.  Demethylates other arginine methylated-proteins such as ESR1.  Has no histone lysine demethylase activity (By similarity).  Required for differentiation of multiple organs during embryogenesis.  Acts as a key regulator of hematopoietic differentiation (By similarity).
What are the official names of this protein?
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, Histone arginine demethylase JMJD6, JmjC domain-containing protein 6, Jumonji domain-containing protein 6, Lysyl-hydroxylase JMJD6, Peptide-lysine 5-dioxygenase JMJD6, Phosphatidylserine receptor, Protein PTDSR.
What is the protein family that this protein belongs to?
Belongs to the JMJD6 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
Protein: ISPG_SHEB5
Sequence: MYNETPIKRRPSTRIYVGNVPIGDGAPIAVQSMTNTKTTDVEATIAQIRALEKVGADIVRVSVPTMDAAEAFKLIKQAVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRSVVECARDHNIPIRIGVNGGSLEKDLMDKYKEPTPQALLESAMRHVDILDRLNFDQFKVSVKASDVFLAVESYRLLAKQIRQPLHLGITEAGGARAGSVKSAVGLGMLLAEGIGDTLRISLAADPVEEIKVGFDILKSLRIRSRGINFIACPSCSRQEFDVISTVNELERRLEDVTTAMDVSIIGCVVNGPGEALVSHIGLTGGHNKSGYYDEGERQKERFDNDNIVDSLEAKIRAKASQMANRIQIKDTTE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RL27_AERHH
Sequence: MAHKKAGGSSRNGRDSEAKRLGVKRFGGETVLAGSIIVRQRGTKFHAGTNVGLGKDHTLFATATGKILFEVKGPLNRKYVSIVAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PROA_DICT6
Sequence: MENLVEKLKKAKESTYILSLLNTNEKNEALRAIANNIEKNIDKIIKENEKDIKRGEEKGLSKAILDRILLNEKRLKDIVKSIEDVIKLPDPVGEIVSMQKRPNGILVGQMRVPIGVIAIIYEARPNVTVDATILALKSGNAIVLRGSSDALNSNIILTNIMKEALSNTKIPQDAVQIIESPEHSVVEELLQMTDYIDVAIPRGSAKFIKHVMNISKVPVIETGAGNNHIYVEEDADFEMARKIIINAKVQRPSVCNAIEKLLVHKNIAEEFLPVIVKDLREYNVEIRGCEKTLKIVKDAIPATEEDWYTEYLDYIIAIKVVDSIDEAIAHINKYNTKHSEAIITKDYHKALKFLRMVDAAAVYVNASTRFTDGGEFGLGAEIGISTQKLHARGPMGLKELTTTKYVIFGEGQIRE
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECK_HUMAN
Sequence: MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVSMLTCLADVREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQPEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNCIPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPSCHSLLLPLSLGLALHLLWTYN
What is the function of this protein?
Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314).  Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).  Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314).  ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314).  Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:9789069, PubMed:18194466).  Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed:9789069).
What are the official names of this protein?
Reversion-inducing cysteine-rich protein with Kazal motifs, hRECK, Suppressor of tumorigenicity 15 protein.
What is the protein family that this protein belongs to?
Belongs to the RECK family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: LIPA_FRAT1
Sequence: MKEISGIKVKVESGSKYTTDHGFHAVKDGIRNKKENAVHVRKPDWLKVQKQDSKEYLKVKSITKKHKLSTVCEEARCPNINECWSHGTATIMLMGSVCTRACKFCSVDTGNPKGWLDKDEPMNAAESVKLMGLEYVVLTSVDRDDLEDGGAGHYAATITAIKNLDENIKVEALTPDFAGINENIDKIINTKVDVIAQNIETVERLTHPVRDPRAGYWQTLNFLKYVKQKSPNVLTKTSIMVGLGETDEEIYKTMDDARSVGVDIITLGQYMQPTKHHLSVERFVTPQQFEEYRKVGLEKGFLEVASGPMVRSSYRADRVFKRNNLDL
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADT4_BOVIN
Sequence: MQREPPKRKQEKKVEKGLFDATSFGKDLLAGGVAAAVSKTTVAPIERVKLLLQVQASSKQISPEAQYKGIVDCLVRIPREQGFLSYWRGNLANVIRYFPTQALNFAFKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLCVVYPLDFARTRLGADIGKGPEERQFKGLGDCIMKIAKSDGIVGLYQGFGVSVQGIIVYRASYFGAYDTVKGLLPKPKETHFLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQSGEAERQYKGTLDCFMKIYQQEGIGAFFRGAFSNILRGTGGALVLVLYDKIKDLLNIDIGGSSSGD
What is the function of this protein?
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).  Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).  Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes.  Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis.  In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity).  Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis.  Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity).  Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity).  Among nucleotides, may also exchange ADP for dATP and dADP (By similarity).  Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1. 5 kDa, and which contributes to cell death.  It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (By similarity).
What are the official names of this protein?
ADP/ATP translocase 4, ADP,ATP carrier protein 4, Adenine nucleotide translocator 4, ANT 4, Solute carrier family 25 member 31.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region (By similarity). May localize to non-mitochondrial membranes (By similarity).
Protein: FADB_SALTY
Sequence: MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGQALEVLEKQHDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTLAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRLPRMLGADSALEIIAAGKDVGAEHALKIGLVDGVVKQEKLIEGAIAVLRQAITGDLDWRAKRQPKLEPLKLSKIEAAMSFTIAKGMVAQTAGKHYPAPMTAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDIETPKQAAVLGAGIMGGGIAYQSAWKGVPVIMKDINDKSLNLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPETVLASNTSTIPIGELASALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKDYRDAIDALFDASRFGQKNGLGFWRYKEDSKGKPKKEEDAAVDDLLASVSQPKRDFSDDEIIARMMIPMINEVVRCLEEGIIASPAEADMALVYGLGFPPFHGGAFRWLDTQGSAKYLDMAQQYQHLGPLYEVPEGLRNKARHNEPYYPPVEPARPVGSLKTA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.