PharMolix/UniProtQA huggingface dataset:
Protein: CINAL_MYCBP
Sequence: MAVSARAGIVITGTEVLTGRVQDRNGPWIADRLLELGVELAHITICGDRPADIEAQLRFMAEQGVDLIVTSGGLGPTADDMTVEVVARYCGRELVLDDELENRIANILKKLMGRNPAIEPANFDSIRAANRKQAMIPAGSQVIDPVGTAPGLVVPGRPAVMVLPGPPRELQPIWSKAIQTAPVQDAIAGRTTYRQETIRIFGLPESSLADTLRDAEAAIPGFDLVEITTCLRRGEIEMVTRFEPNAAQVYTQLARLLRDRHGHQVYSEDGASVDELVAKLLTGRRIATAESCTAGLLAARLTDRPGSSKYVAGAVVAYSNEAKAQLLGVDPALIEAHGAVSEPVAQAMAAGALQGFGADTATAITGIAGPSGGTPEKPVGTVCFTVLLDDGRTTTRTVRLPGNRSDIRERSTTVAMHLLRRTLSGIPGSP
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: CEP68_HUMAN
Sequence: MALGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEGIPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQVEKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQWKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVVGLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYEDLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPAEATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRGAKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLPPGAALQGSGDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRWPFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTSLKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESHADRLYDSILASLDMLAGCTLIPDKKPMAAMEHPCEGV
What is the function of this protein?
Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621).  Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).  Contributes to CROCC/rootletin filament formation (PubMed:30404835).
What are the official names of this protein?
Centrosomal protein of 68 kDa, Cep68.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis.
Protein: GSA_CHLAB
Sequence: MPIIEESTMTYAEACRYFPGGVNSPIRACIPVGILPPIVSSAHRDIFIDSFGKTFIDFCGSWGSLIHGHGHPKILDVICNSASQGTSYGLTSENEISLAATLFSCLEFEDHKVRFVSSGTEATMTAVRLACATTGRSIMIKFLGCYHGHADVLLKGISIDESNIHQVPHIVDTYFSGNPYLPLNLILPYNDIQIFKEVMLQVGERVACVIFEPIAINMGVVLPKPGFIEGVITISRRFAALTIMDEVVTGFRMGIRGVRSIMDVDSDITVYGKILGGGMPVAAFLAHHRIMDHLLPLGQVFQAGTLSGNPIAMAVGKASLELCREVDFYPKLENLAQSFFAPIEEVICHQGFPVSLVRAGSMFSFFFRETPPTNLREVQECDHQMFGVFYRHVFAQGVYLSPAPMEASFLSSVHSKENLAYTQNVLIDSLMKTFGSL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_HAPMA
Sequence: TLYFIFGIWSGLLGTSLSLMIRTELGQPGSLLNDDQLYNVIVTAHAFVMIFFLVMPVMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLSSAPVESGAGTGWTVYPPLSSNLAHMGPSVDLAIFSLHLAGISSIPGAINFITTIINMRWEGMMMERLPLFVWSVFITAILLLLSLPVLAGAITMLLTDRNFNTTFFDPSGGGDPILYQHLF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: M4GDB_DANRE
Sequence: MENSSKEDYKIQSFDLETQKLLKTALKDPGSVDLEKVSSVIVDQSLKDQVFSREAGRICYTIVQAEAKQTNGSVFRRNLLNRLQQEFKAREETRKRSTQEWVCLVSFICNIFDYLKVNNMPMVALVHPVYDCLFRLAQSDALKNEEEVDCLVLQLHRIGDQLEKMNVQLMDELFNLLRDGFLLQEDLSSMGRLLLLEILEFRAGGWKLSDTAQKYYYSEVTD
What is the function of this protein?
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop.  May participate in circularizing those mRNAs specifically enhancing their translation (By similarity).
What are the official names of this protein?
MIF4G domain-containing protein B.
What is the protein family that this protein belongs to?
Belongs to the MIF4GD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: LEU1_ESCF3
Sequence: MSQQVIIFDTTLRDGEQALQASLSAKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQTIARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIERAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEFAGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCSLEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIHQDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAFLKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKAEAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGLATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: GATA_PEDPA
Sequence: MKFFDITVTELHQKLVDKELTVTELVSETLDQIEADQKVLNDFVTINREGALAQARAIDEKGINPDNIWAGIPIAIKDNIVTKGIKTTAASKMLSNFTPIYDATVIERLQANDVIIIGKTNMDEFAMGGSTETSYFGDTRNPWDHTKVPGGSSGGSATTVSAGNSIAALGSDTGGSIRQPASYTGIVGVKPTYGRISRYGLIAFGSSLDQIGPMTRTVKDNAALLNIIAGMDERDLTSSDKKVPDFTSKIGKDIKGMKIGLPKEYLGDGINEDVKKVVRQAVETLTNLGATIEEISLPRSKYGVAAYYIIGSSEASSNLQRFDGIRYGHRAQDVKNLEDVYVKSRSEGFGDEVKRRIMLGTYSLSAGTYDAYFKKAAQVRTLIINDFNKIFEDYDLIIGPTAPTPAYAIGAEVDDPTTMYMNDVLTIPVNLAGLPAMSVPAGFSDNMPVGLQIIAKPFDEETMYQAGAAFEAATEVHSKHPEMEDK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: DUT_BORPA
Sequence: MKSVDLKILDARMREYLPAYATPGSAGLDLRACTEASLVIEPGQTVLVPTGLAIHIGDPRYAAMILPRSGLGHKHGIVLGNLVGLIDSDYQGQLMVSTWNRGTQPFTLDPMERLAQLVIVPVQQVAFNVVEDFDASERGAGGFGSTGRA
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: YCZG_BACSU
Sequence: MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTCADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQDRW
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YczG.
Protein: RSMH_MYCCT
Sequence: MDKHIPVLLDESIKYLNIKLNGIYVDCTLGRAGHASEILKRLSQNGFLYAIDQDKTAIGQAKEKLEKISNNFFLIQGNFSNLSALLAINHIFSVDGILYDLGVSSPQLDIGSRGFSYRIDGPLDMRMDITNNNLTADTIINQYSETQIEDILFKYGEESFAKSIAKKIVLSRPINSTLQLVEVIKSALPQKVLKQKKHPAKKTFQALRIFINNELIVLENSLKQALDLLNSKGRICVITFHSLEEKIVKNIFNSSTNYFQEQLFNNLPIKANLNSQFKLVIKKPIKPSLLELENNHRSHSAKLWVIEKN
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR11_CITSI
Sequence: MAKSPPRSGSRRPGRIGSRKSGRRIPKGVIHVQASFNNTIVTVTDVRGRVISWSSAGTCGFRGTRRGTPFAAQTAAGNAIRAVADQGMQRAEVMIKGPGLGRDAALRAIRRSGILLNFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ESCA_CALVI
Sequence: HQQFHCPSAEGNQVKKVFSCKNCDKTYVSLGALKMHIRTHTLPCKCPICGKAFSRPWLLQGHIRTHTGEKPFSCQHCQSAFV
What are the official names of this protein?
Escargot/snail protein homolog.
What is the protein family that this protein belongs to?
Belongs to the snail C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROK_FRACC
Sequence: MGEPATDAWTGPMAWTGPMVVLVGAPGAGKTTVGTQLARRWGVGFRDTDADIEAALGTTVADIFLDHGEEYFRLAERRAVAAALADHRGVLALGGGAVLDAENRTLLAGHRVVYLEVGVSDAVRRVGLARDRPLLVEGPRTRLAALLRARRPLYAEVATVVIDTAGHEPDEVTDLLAAALGPLLAGGSEPDEAADAAGGSEPDEAADAAGGSEPDEAADAAGGKR
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_METI4
Sequence: MVEPKIRPLGERVLVKLIEEQEVRKGGIIIPDTAKEKPQEATVIAVGPGKLDENGKRIPIEVKKGDKVLISKYGGTEVKIDGESFQILREDDILAIIEG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZCH14_MOUSE
Sequence: MASNHPAFSFHQKQVLRQELTQIQSSLNSGGGGGGGGGGGGKSAPGPSGALPTCSACHKMAPRTETPVSSISNSLENALHTSAHSTEESLPKRPLGKHGKVSVEKIDLKGLSHTKNDRSVECSFEVLWSDSSITSVTKSSSEVTEFISKLSQLCPEENLDKLIPCLAGPDSFYVERNHVDLEAGLRFLASAPSHTLKHDHVRKFFSSSSPSQQLQSPSPGNPSLPKVGAVMGVSGRPVCGVAGIPSSQSSAQHHLQHSASTSASLPHCSHTGGTGSALAYRTQVDNSPTILMPSSLQTPQPQEQNGILDWLRKLRLHKYYPVFKQLTMEKFLSLTEEDLNKFESLTMGAKKKLKTQLELEKEKSERRCLNSSAPSLVTSSGVARVTPTSHVGPVQPGRSSSHASELRVEVEPPAHQLPREGSSSEYSSSSSSPMGVQVREESSDSAEESDRRVDIHVEGTEKEKPVMLLAHFPSSSARPTAQVLPVQNETGSSPAAHHPLPPQLMPAASHLAPVRMLNSVHKSDRGGADVKLLSSSVHSLLSLEERNKGPGPRSGTKVDKSFGGAVLDPLPSAAPHPPGQGLSGLVENNAVSPTVSFGPRAKVVHAATLDRVLKTAQQPALTVESSSATTGTPSTVLHVARPPIKLLLASSVPADAAIAGQTSCPNNGQISVPPAIMNPRTALYTANTKVAFSAVSSVPVGPLQGSFCANSNTASPSSHPSTSFASMASLPSCPAPSSSPALSSVPESSFYSGGAGSSSPGNIPASSQSHHHHHHHQQPPAPPQPAPPPPGCIVCTSCGCSGSCGSNGLTVSYANYFQHPFSGPSVLTFPFLPFSPMCGNGYVSTQQYGGGSAFPVVHTPYNGSVTPDPVLGGQSTFAVPPMQNFMAGTAGVYQAQGLVGSTNGSSHKKSGNLSCYNCGATGHRAQDCKQPSMDFNRQGTFRLKYAPPAESLDSTD
What are the official names of this protein?
Zinc finger CCHC domain-containing protein 14, BDG-29.
Protein: FA12_PIG
Sequence: MRALLLLGILLVSLESALLIPPWKDPRKHKVMASEHTVVLTVTGEPCHFPFQYYRQLYYKCIQRGQRGPRPWCATTPNFEKDQRWAYCLEPMKVKDHCNKGNPCQKGGTCVNMPNGPHCICPDHFTGKHCQKEKCFEPQFLQFFQENEIWHRFEPAGVSKCQCKGPKAQCKPVASQVCSTNPCLNGGSCLQTEGHRLCRCPTGYAGRLCDVDLKERCYSDRGLSYRGMAQTTLSGAPCQPWASEATYWNMTAEQALNWGLGDHAFCRNPDNDTRPWCFVWRGDQLSWQYCRLARCQAPIGEAPPILTPTQSPSEHQDSPLLSREPQPTTQTPSQNLTSAWCAPPEQRGPLPSAGLVGCGQRLRKRLSSLNRIVGGLVALPGAHPYIAALYWGQNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEQCQTLAVRSYRLHESYSPKTYQHDLALVRLKETADGCCAHPSPFVQPVCLPRSVASSAEPEGALCEVAGWGHQFEGAEEYSSFLQEAQVPLISPERCSAADVHGAAFTPGMLCAGFLEGGTDACQGDSGGPLVCEDETAERQLVLRGIVSWGSGCGDRLKPGVYTDVANYLAWIQEHTTS
What is the function of this protein?
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin.  Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa.  Alpha-factor XIIa activates factor XI to factor XIa (By similarity).
What are the official names of this protein?
Coagulation factor XII, Hageman factor, HAF.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: VAC8_SCHPO
Sequence: MGNCLSCCEKSKDEQYEPLLADREREAVADLLSFLEDRNEVNFYSEEPLRALTILAYSDNLDLQRSAALAFAEITEKDVREVDRETIEPVLFLLQSPDAEIQRAASVALGNLAVNAENKALVVKLNGLDLLIRQMMSPHVEVQCNAVGCITNLATLDENKSKIAHSGALGPLTRLAKSKDIRVQRNATGALLNMTHSYENRQQLVSAGTIPVLVSLLPSSDTDVQYYCTTSISNIAVDAVHRKRLAQSEPKLVRSLIQLMDTSSPKVQCQAALALRNLASDERYQIEIVQSNALPSLLRLLRSSYLPLILASVACIRNISIHPLNESPIIDAGFLRPLVDLLSCTENEEIQCHAVSTLRNLAASSERNKRAIIEANAIQKLRCLILDAPVSVQSEMTACLAVLALSDEFKSYLLNFGICNVLIPLTDSMSIEVQGNSAAALGNLSSNVDDYSRFIECWDSPAGGIHGYLVRFLSSEDSTFAHIAAWTIVQLLEAGVPRLTAFIQSSDDIIELLNDIVARDANNGEYEDGEGDVILLSGRALHLIEQDTDS
What is the function of this protein?
Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
What are the official names of this protein?
Vacuolar protein 8.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: CH60_SHESM
Sequence: MAAKEVVFGNDARVKMLAGVNILANAVKVTLGPKGRNVVLDKSFGSPLITKDGVSVAKEIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVTEGLKAVAAGMNPMDLKRGIDKAVAAAVIELKNLSQDCADSKAIAQVGTISANSDESIGEIIATAMEKVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELDHPFVLLVDKKISNIRELLPILEGLAKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDVAILTGGTVIAEEIGLELEKATLEDLGTAKRVVITKDNTTIIDGNGEQAQIEARVSQIKQQIEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALVRVASKIADVEVANEDQKHGVVIALRAMEAPLRQIATNAGEEASVVANTVKNGSGNYGYNAGNDTYGDMLEMGILDPTKVTRSALQFAASIAGLMITTEAMVAELPKADAPDMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP_FRATO
Sequence: MITNNLVPTVIEKTAGGERAFDIYSRLLKERIVFLNGEVNDHSANLVIAQLLFLESEDPDKDIYFYINSPGGMVTAGMGVYDTMQFIKPDVSTICIGLAASMGSLLLAGGAKGKRYSLPSSQIMIHQPLGGFRGQASDIEIHAKNILRIKDRLNKVLAHHTGQDLETIVKDTDRDNFMMADEAKAYGLIDHVIESREAIIK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSGA8_MOUSE
Sequence: MDVPTSSTDSQEVKPIMPIRTKAACKFYPPHILCGKGAKTNKRGKRGGAQKASTKKDIGETTPPVAKKSKVAKEPTMLAAAAAPEAAASPESSAAAAAPEAAASPESSAAAAAPEAAASPESSAAAAAPEAAASLESSAAAAAPEAAAAPATPAAPEAAAAPEVAAAPATPAAPEATAAPAAPEAATTPAAPEAPAAAPAVEEEEMVWEAAAVVGEAAVKPPEEEPTSGEAVATTTMT
What are the official names of this protein?
Testis-specific gene A8 protein, Haploid-specific alanine-rich acidic protein located on chromosome X, Halap-x.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleoplasm. Note=Strongly expressed in the nucleus of round spermatids. As spermatids mature, nuclear expression declines and cytoplasmic expression increases. Elongating spermatids have mainly cytoplasmic expression.
Protein: RIHC_ECO5E
Sequence: MRLPIFLDTDPGIDDAVAIAAAIFAPELDLQLMTTVAGNVSVEKTTRNALQLLHFWNAEIPLAQGAAVPLVRAPRDAASVHGESGMAGYDFVEHNRKPLGIPAFLAIRDALMRAPEPVTLVAIGPLTNIALLLSQCPECKPYIRRLVIMGGSAGRGNCTPNAEFNIAADPEAAACVFRSGIEIVMCGLDVTNQAILTPDYLSTLPQLNRTGKMLHALFSHYRSGSMQSGLRMHDLCAIAWLVRPDLFTLKPCFVAVETQGEFTSGTTVVDIDGCLGKPANVQVALDLNVKGFQQWVAEVLALVP
What is the function of this protein?
Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity.
What are the official names of this protein?
Non-specific ribonucleoside hydrolase RihC, Purine/pyrimidine ribonucleoside hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihC subfamily.
Protein: Y1266_PYRAB
Sequence: MPFGWGRGRGRRRKRRMIGFLPQVRHFYPAIPPVSIRQPPIIMTYEEFEALRLVDYEGLTQEEAGKRMGVSRGTLWRALTSARKKVAQMLVEGRELIILPQGNEVVSDEE
What are the official names of this protein?
UPF0251 protein PYRAB12660.
What is the protein family that this protein belongs to?
Belongs to the UPF0251 family.
Protein: ACDH4_RHOJR
Sequence: MTKALAAIVGSGNIGTDLLYKLLRSEIIEPRWMIGVDPDSEGLKRAADRGVIASAEGVDWLLAQDERPDIVFEATSAYVHRANAPRYRELGIQAVDLTPAALGPAVVPAVNMGEHRTAPNVNLITCGGQATIPMVYAVSRITEVAYAEIVASVASPSAGPGTRANIDEFTITTSRGIETIGGAKKGKAIIILNPAEPPMFMKDTVFCSIPADADRDAITASIHDVAASVQAYVPGYRLRAEPQFDDPTPISGGLARVGIFLEVEGAGDFLPPYSGNLDIMTAAATKVGESFATQILGASV
What are the official names of this protein?
Acetaldehyde dehydrogenase 4, Acetaldehyde dehydrogenase [acetylating] 4.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: CAIT_ECO55
Sequence: MKNEKRKTGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQNWKD
What is the function of this protein?
Catalyzes the exchange of L-carnitine for gamma-butyrobetaine.
What are the official names of this protein?
L-carnitine/gamma-butyrobetaine antiporter.
What is the protein family that this protein belongs to?
Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCX4_TITOB
Sequence: MTRFVLFISCFFLIGMIVECKDGYLMEYGGCKMSCLMKKGTFCAEECTRMKGKDGYCYAWLACYCYNMPDWVKIWNRATNKCGKRK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  This toxin shows moderate inhibition of Nav1. 1/SCN1A, Nav1. 2/SCN2A, and Nav1. 4/SCN4A, and promotes a left voltage shift on these channels.  It exhibits similar potency on Nav1. 2/SCN2A and Nav1. 4/SCN4A (40-50% peak current inhibition at 0. 5 uM), and weaker inhibition on Nav1. 2 (20-30% peak current inhibition at 0. 5 uM).
What are the official names of this protein?
Beta-toxin To4, PT-beta* NaTx13.9, Toxin Tc54.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PFDA_METAR
Sequence: MAAEANEDQIRELVAKMQAYQGRMEALQQQANLIQASINDVDSALKAITSLEGAGEGHELLVPIGAGSFVHATIAKPDKVLVGLGADISVERTVADARKIFQARRTELEKALAETNGVLNKVAGELMRLQQEAEKYRQ
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit alpha, GimC subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTB_ECO7I
Sequence: MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNSAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGRGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFTNMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLVEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.