PharMolix/UniProtQA huggingface dataset:
Protein: Y2706_ARATH
Sequence: MSCFGCCGEDDDMHKTADYGGRHNQAKHFPPGNDARHHQASETAQKGPPVVKLQPIEVPIIPFSELKEATDDFGSNSLIGEGSYGRVYYGVLNNDLPSAIKKLDSNKQPDNEFLAQVSMVSRLKHDNFVQLLGYCVDGNSRILSYEFANNGSLHDILHGRKGVKGAQPGPVLSWYQRVKIAVGAARGLEYLHEKANPHIIHRDIKSSNVLLFEDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGQLNAKSDVYSFGVVLLELLTGRKPVDHRLPRGQQSLVTWATPKLSEDKVKQCVDARLGGDYPPKAVAKLAAVAALCVQYEADFRPNMSIVVKALQPLLNARAVAPGEGVH
What are the official names of this protein?
Probable receptor-like protein kinase At2g47060.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: RL1_STAAN
Sequence: MAKKGKKYQEAASKVDRTQHYSVEEAIKLAKETSIANFDASVEVAFRLGIDTRKNDQQIRGAVVLPNGTGKSQSVLVFAKGDKIAEAEAAGTDYVGEAEYVQKIQQGWFDFDVVVATPDMMGEVGKLGRVLGPKGLMPNPKTGTVTMDVKKAVEEIKAGKVEYRAEKAGIVHASIGKVSFTDEQLIENFNTLQDVLAKAKPSSAKGTYFKSVAVTTTMGPGVKIDTASFK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: GATB_ROSDO
Sequence: MLDLTYETPAPKVISGAKEDWELVIGMEVHAQVTSAAKLFSAASTQFGAEPNNNVSFVDAAMPGMLPTINEYCVEQAVRTGLGLKAEINLHSAFDRKNYFYPDLPQGYQISQLYHPIVGEGEVLVEMGNGTARLVRVERIHLEQDAGKSIHDMDPNMSFVDLNRTGVALMEIVSRPDIRGPEEAAAYLGKLRQILRYLGTCNGDMQSGAMRADVNVSICRPGQYEKYQATQDFSHLGTRCEIKNMNSMRFIQQAIEVEARRQIAIVEAGGTVDQETRLYDPDRNETRSMRSKEEAHDYRYFPDPDLLPLEIEQAWVDDIAANLPELPDAKKARFRNDFGLSDYDASVLTADLDSAGYFEAVAAGRDGKMAANWVINELFGRLKKEDHAITDSPVSPAQLGGIIDLIASDAISGKIAKDVFEICYTTGRDPAEIVETEGMKQVTDTGAIEAAVDEIIAANPDQVAKARENPKLAGWFVGQVMKATGGKANPKVVNQLIAKRLAE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: TRIM5_HOOHO
Sequence: MASGILVNVKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHKTSMPDEGERSCPVCRISYQHKNIRPNRHVANIVEKLREVKLSPEEGQKVDHCARHGEKLLLFCREDRKVICWLCERSQEHRGHHTFLTEEVAQEYQMKLQAALQMLRQKQQEAEELEADIREEKASWKTQIQYDKTNILADFEQLRHILDWVESNELQNLEKEKKDVLKRLMKSEIEMVQQTQSVRELISDLEHRLQGSVMELLQGVDGIIKRMKNVTLKKPETFPKNKRRVFRAADLKVMLEVLRELRDVRRYWVDVTVAPNNISYAVISEDMRQVSSPEPQIICEAQGTISQTFVNFNYCTGILGSQSITSGKHYWEVDVSKKSAWILGVCAGLQPDAMYNIEQNENYQPKCGYWVIGLEERVKCNAFQDGSFHTPSAPFIVPLSVNICPDRVGVFLDYEACTVSFFNITDHGFLIYKFSRCSFSQPVFPYLNPRKCTVPMTLCSPSS
What is the function of this protein?
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses.  Blocks viral replication early in the life cycle, after viral entry but before reverse transcription.  In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice.  Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3).  Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell.  Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2.
What are the official names of this protein?
Tripartite motif-containing protein 5, RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localizes in cytoplasmic bodies. Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27. In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1.
Protein: Y209_AQUAE
Sequence: MDILERTFKKLTRLKDNLQDLSQEEAYEVFRAILEGKLSDIKTTAFLTAMRIKGETSEELLGVIKAIKERMNFPQKKEDALDLGLNYDGKNRTIYILPSALWLCSRLGVEFTNHYALGAPTKEGVTLYEVVKELGVDMNVSFVDQKNYAPELYKLMPLRRELGFRSLINTVEKFLNPFQTKKIVVSIFHKPYFDKNAELLELLGIEDYTIIKGLEGGIEPLPDRPTLVKKRGKDIESIEPKSLGLEMPKDVHSENVLRDSLEINRKIIDGRERGEFFNWALYTAGVLLYAAGECESVEEGVGRVEKEST
What are the official names of this protein?
Uncharacterized protein aq_209.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: TX60A_ACTVL
Sequence: MSPYFKLSSALIFLAITMEALCSPIENTSTSNKDNDKETEHIEISAKPSGISRGALGQGFEIHREDLLSKQFEATGEKIFEDLPMDECTVTTTLGTIERDDSFYNSTESLYQSVASSTKISGSLKGAYTLGVSVAAVTNNIASSEEEVQGLSLNLKAYSMSSILKKNCVNTKPLSKDLVSDFEALDSEITKPWKLSSWKKYKVLLEKYGSHIVKESISGSSIYQYVFAKSNQKFNHRSFTVKACVSLAGPKNASKVGFAGCTGVSQQEIEQSSSQSMIKKLVVRGGKTETRASLIGELDPDQINKFLIEAETDPSPIQYKFEPIWTILKNRYVGTEHFAKAVNLEQFYKGFLHFGCSFLHTSNADNADVEIQKFDFAKTSDPDAPTYVCKVGPEGCQHHEDCHYRAAFWCECGGPYDLARTCLRYKTEKLNSGSTKRECYPNKESGFAWHGCQLHGLSCWCSAPNKNWEETWSGEDTNNALNDVHQVLMEKKRRDQAK
What is the function of this protein?
Is lethal to mice, and may cause hemolytic activity.
What are the official names of this protein?
DELTA-thalatoxin-Avl2a, DELTA-TATX-Avl2a, Toxin AvTX-60A, Av60A.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: CLPS_BORA1
Sequence: MSSTLDSQHDLVAEKQSARTAPPPMYQVVLLNDDYTPMEFVVKVLQKFFGKNQEEATRIMLQVHHEGRGICGVYVRDVAATRIAQVAQYARARQHPLQCIMEPV
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: MACO1_DANRE
Sequence: MKRRNADCSKLRRPLKRNRITEGIHSSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPKQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKHFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQRQERETEEATSKGMSEADSVLVAQNGTAINKKLPISLPELEYKEKGKDSAKDKKQQQHSIGINNNILQTVDAKLQDIEYMENHLNAKRLNNELGGSAENLFLKEEVGAGGGSAPSKHYKNSSPRSHNSTNGSVPSSSSNRSDKKQKCTGKNLAPHRDLMENCIPNNQLSKPDALVRLEQDIKKLKADLQASRQVEQDLRSQISSLSSAERSMRSELGQLRQENELLQNKLHNAVQAKQKDKQTIVQLEKRLKAEQEARAAVEKQLAEEKKRKKMEEATAARAVALAAASRGECTDSLKSRIRELESECKKLTHDMKLKEEQIRELELKAQELHKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKEQEIKELKQKIAEVMAVMPSITYSAETNNMTPVTPHYSSKFMDTSPSSLDPNASVYQPLKK
What is the function of this protein?
May play a role in the regulation of neuronal activity.
What are the official names of this protein?
Macoilin-1, Transmembrane protein 57a.
What is the protein family that this protein belongs to?
Belongs to the macoilin family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Rough endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MOAE_PASMU
Sequence: MSDIQIAVQEQPFDQNAAYRWLSEQHSVGATVVFVGKVRDLNLGDEVSSLYLEHYPAMTEKALTEIVAQAKARWDIQRVCVIHRVGLLQTGDEIVFVGVSSAHRGEAYQANEFIMDFLKSKAPFWKKEKTTQGERWIESRDTDQQALARW
What is the function of this protein?
Converts molybdopterin precursor Z into molybdopterin.  This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group.  The sulfur is provided by MoaD (By similarity).
What are the official names of this protein?
Molybdopterin synthase catalytic subunit, MPT synthase subunit 2, Molybdenum cofactor biosynthesis protein E, Molybdopterin-converting factor large subunit, Molybdopterin-converting factor subunit 2.
What is the protein family that this protein belongs to?
Belongs to the MoaE family.
Protein: ARAB_SHIDS
Sequence: MAIAIGLDFGSDSVRALAVDCTTGEEIATSVEWYPRWQKGQFCDAPNNQFRHHPRDYIESMEAALKTVLAELSVEQRAAVVRIGVDSTGSTPAPIDADGNVLALRPEFAENPNAMFVLWKDHTAVEEAEEITRLCHALGNVDYSRYIGGIYSSEWFWAKILHVTRQDSAVAQSAASWIELCDWVPALLSGTTRPQDIRRGRCSAGHKSLWHESWGGLPPASFFDELDPILNRHLPSPLFTDTWTADIPVGTLCPEWAQRLGLPESVVISGGAFDCHMGAVGAGAQPNALVKVISTSTCDILIADKQSVGERAVKGICGQVDGSVVPGFIGLEAGQSAFGDIYAWFGRVLGWPLEQLAAHHPELKEQINASQKQLLPALTEAWAKNPSLDHLPVVLDWFNGRRTPNANQRLKGVITDLNLATDAPLLFGGLIAATAFGARAIMECFTDQGIAVNNVMALGGIARKNQVIMQACCDVLNRPLQIVASDQCCALGAAIFAAVAAKVHADIPSAQQKMASAVEKTLQPRSEQAQRFEQLYRRYQQWAMSAEQHYLPTSAPAQAAQAVPTL
What are the official names of this protein?
Ribulokinase.
What is the protein family that this protein belongs to?
Belongs to the ribulokinase family.
Protein: CLCB_YERP3
Sequence: MLRRLVISIMLGMVSALIVWLFHQAMLGLEWLLFSRTDGSLVAAAASITGWRRALTPALGGLAAGLLLWAYQRYQHRKPSAPTDYMEAIEIGDGRLDVSASLVKSLASLLVVSSGSAIGREGAMVLLAALFASVFAQRYAKPKEWKLWVACGAAAGMASAYHAPLAGSLFIAEILFGTLMLASLGPVVIAAVSALLTTNLLQGGQETLYQVQTLPSPWPVQYFLMALLGLMAGFSGPLFLKAMAASSHAFRSLNLLPPLQLALGGIIVGLLSLIFPEVWGNGYSVVQSLLTTPPGVLLIGGILICKLLAVLASSGSGAPGGVFTPTLFVGAALGMLCGQIFSLWPVLGDNIGLLMALTGMATLLAATTHAPIMAALMVCEMTGEYTLLPGLLLSCVIATTIARWLRPISVYRSH
What is the function of this protein?
Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
Voltage-gated ClC-type chloride channel ClcB.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PA2AG_AUSSU
Sequence: MYPAHLLVLLAVCVSLLGASNIPLPSLDFEQFGKMIQCTIPCEESCLAYMDYGCYCGPGGSGTPLDELDRCRQTHDNCYAEAGKLPACKAMLSEPYNDTYSYGCIERQLTCNDDNDECKAFICNCDRAAVICFSGAPYNDSNYDIGTIEHCK
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that inhibits collagen-induced platelet aggregation.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
What are the official names of this protein?
Acidic phospholipase A2 S16-19, svPLA2, ASPLA16, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: COBT_SHISS
Sequence: MQTLADLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLGRLEALAIQLAGMPGLNGVPHVGKKAVLVMCADHGVWEEGVAISPKEVTAIQAENMTRGTTGVCVLAAQAGANVYVIDVGIDTAEPIPGLINMRVARGSGNIASAPAMSRHLAEKLLLDVICYTRELAKNGVTLFGVGDLGMANTTPAAAIVSTITGRAPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVGGFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIALSHLGLEPYLNMEMRLGEGSGAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: RL27_CAMJD
Sequence: MAHKKGQGSTQNNRDSIGRRLGVKKFGGEFVRAGNIIIRQRGTATHAGNNVGMGKDHTIFALIDGFVKFERKDKDRKKVSVYPA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RWDD1_MOUSE
Sequence: MTDYGEEQRNELEALESIYPDSFTVLSESPPSFTITVTSEAGENDETVQTTLKFTYSEKYPDETPLYEIFSQENLEDNDVSDILKLLALQAEENLGMVMIFTLVTAVQEKLNEIVDQIKTRREEEKKQKEKEAEEAEKKLFHGTPVTIENFLSWKAKFDAELLEIKKKRMKEEEQAGKNKLSGKQLFETDHNLDTSDIQFLEDAGNNVEVDESLFQEMDDLELEDGEDDPDYNPVAPGSDSSD
What is the function of this protein?
Protects DRG2 from proteolytic degradation.
What are the official names of this protein?
RWD domain-containing protein 1, DRG family-regulatory protein 2, IH1.
What is the protein family that this protein belongs to?
Belongs to the RWDD1/GIR2 family.
Protein: HBG_ALOBE
Sequence: MSNFTAEDKAAITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGSLSSPSAIMGNPKVKAHGVKVLTSLGEAIKNLDDLKGTFGSLSELHCDKLHVDPENFRLLGNVLVTVLAILHGKEFTPEVQASWQKMVAGVASALASRYH
What is the function of this protein?
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
What are the official names of this protein?
Hemoglobin subunit gamma, Gamma-globin, Hemoglobin gamma chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: CH10_CHLPM
Sequence: MNLKPLADRVIVKPAPAEEKTKGGLYIPDTGKEKPMYGEVVAVGAGKMSDSGQLLEMPVKAGDKVLYGKYSGTEVSVEGEDYLIMRESDIFAILG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_BACHK
Sequence: MHILVVSVNYRTAPVEFREKLTFQAAELERAMTTLQNQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLEIEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCALLEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEKIQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETMESLERKIPNLSDRERKVISKHTKSIINQLLKDPILVAKEIAAEEGADEKLALFAKIFDLEMEDVESRAEEVEHKRVWTPSVPSL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: LYG1_HUMAN
Sequence: MSALWLLLGLLALMDLSESSNWGCYGNIQSLDTPGASCGIGRRHGLNYCGVRASERLAEIDMPYLLKYQPMMQTIGQKYCMDPAVIAGVLSRKSPGDKILVNMGDRTSMVQDPGSQAPTSWISESQVSQTTEVLTTRIKEIQRRFPTWTPDQYLRGGLCAYSGGAGYVRSSQDLSCDFCNDVLARAKYLKRHGF
What are the official names of this protein?
Lysozyme g-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 23 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRUB_MOOTA
Sequence: MVMGFVNVLKPPGLTSHDVVQNLRRLLKVKRIGHGGTLDPLAAGVLPVAVGTATRLLEYLQGGDKAYRAEFILGLKTDTQDLGGRVLARKPCPPFTEKDLQAATRPFTGTIRQVPPMVSAVHYQGRRLYELAREGLEVERPARQVTIHEFRLIRAWPDGPYYRALIDITCSRGTYIRTLGADWGDYLGVGATLAFLLRTRAGSFRLTDAWTLEEIAGAIDRGERTFLLPPAAGLAHLPVIIVPGEFIRHVSNGVAIKGDVCRPLPSLREGDIVRLETGEGQLLALARVEPDTRGSFLLKPHKVLK
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: RPO6_ARCFU
Sequence: MGIKVKFPFEYTRFEKARIIGARALQIAMGAPVLIETDKTEPLEIALEEFNRGVIPITVRRRRNEFVWLERYDLF
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo6, DNA-directed RNA polymerase subunit K.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GET3_USTMA
Sequence: MSSAAVVEDALEPTLQNILDQKTLKWLFVGGKGGVGKTTTSCSLAIQLSKVRESVLLISTDPAHNLSDAFGQKFGKEATKVNGFDNLSAMEIDPNSSIQEMIEQSDSQGGAMGSMMQDLAFAIPGVDEAMGFAEIMKHVKSMEYSVIVFDTAPTGHTLRFLSFPSVLEKALAKFSTLGRSLGPMLGQFQSMLGGGGPNQEDMFAKLESMREVITEVNTQFKDPEKTTFVCVCIAEFLSLYETERLIQELTSYEIDTHAIVCNQLLYPKKDSNCQHCRVRKQMQDKYVGEMMELYADDFHIVKMPLLTEEVRGTDKLKDFSNFLVTPYVPPTE
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: HSP70_LEIAM
Sequence: MTFDGAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFNDLVVQSDMKHWPFKVTTKGDDKPVISVQYRGEEKTFTPEKISSMVLLKMKETAEAYLGKQVKKAVVTVPAYFNDSQRQATKDAGTISGLEVLRIINEPTAAAIAYGLDKGDDGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVTFFTEEFKRKNKGKNLASSHRSLRRLRTACERAKRTLSSATQATIEIDALFDNVDFQATINRARFEELCGDLFRSTIQPVERVLQDAKMDKRSVHDVVLVGGSTRIPKVQSLVSDFFGGKELNKSINPDEAVAYGAAVQAFILTGGKSKQTEGLLLLDVTPLTLGIETAGGVMTALIKRNTTIPTKKSQIFSTYADNQPGVHIQVFEGERAMTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNQITITNDKGRLSKDEIERMVNDAMKYEADDKAQADRVEAKNGLENYAYSMKNTLGDSNVSGKLDDTDKSTLNKEIEAALEWLSSNQEATKEEYEHKQKELENVCNPIMTKMYQSMGGGAGGMAGMPDMSSMSGARPAGGASSGPKVEEVD
What are the official names of this protein?
Heat shock 70 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PCDB4_PANTR
Sequence: MKKLGRIHPNRQVLAFILMVFLSQVRLEPIRYSVLEETESGSFVAHLTKDLGLGIGELASRSARVLSDDDEQRLQLDRQTGDLLLREKLDREELCGPIEPCVLHFQVFLEMPVQFFQGELLIQDINDHSPVFPEREVLLKILENSQPGTLFPLLIAEDLDVGSNGLQKYTISPNSHFHILTRNHSEGKKYPDLVQDKPLDREEQPEFSLTLVALDGGSPPRSGTVMVRILIMDINDNAPEFVHTPYGVQVLENSPLDSPIVRVLARDIDAGNFGSVSYGLFQASDEIKQTFSINEVTGEILLKKKLDFEKIKSYHVEIEATDGGGLSGKGTVVIEVVDVNDNPPELIISSLTSSIPENAPETVVSIFRIRDRDSGENGKMICSIPDNLPFILKPTLKNFYTLVTERPLDRETSAEYNITITVTDLGTPRLKTQQSITVQVSDVNDNAPAFAQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQAFEFRVGASDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQSQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGDSGTGEFKFLKPIFPNLLVQDTGREVKENPKFRNSLVFS
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin beta-4, PCDH-beta-4.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HOZ1A_PSESY
Sequence: MGNVCVGGSRMSHQVYSPDRADTPPRSERNTPDRRQRAAGDAERTQSMRLQQKINDLKPYVRHARGPIKAYGQAALDRASGKKTSVSFAELDATHLDAMVYIENQRNPGLNLKHFRDHKELIQALQSDGPSAFRAIFPQTCPETGQTLKHHVMADVRLHQGGAPTIIITEPAVIVGARYQQLQRHNLTLEDLSESGVPLSQVAIIETQAQKTSDDCVMYSLNYAIKAHKNAAQFDDIHHGLQHGTLSTESESRARTTLGALEASSSYSVMHEGAHAAFGADVLPVDFYKHGASLTQAKQLMKRPDGRMAGRVNSEGHSEAENLVQRNQAFRVKRRELLDDETPSNTQFSASIDGFRLQEIKRVLAEEQR
What is the function of this protein?
Serine/threonine-protein acetyltransferase translocated into infected cells, which impairs host microtubule network and host immunity by mediating acetylation of target proteins (PubMed:20636323, PubMed:22319451, PubMed:24204266, PubMed:27525589).  Blocks secretion in host cells by mediating acetylation of host tubulin, thereby impairing host microbubule network (PubMed:22319451).  Impairs host cell immunity by mediating acetylation of host TIFY/JAZ transcription repressors (Arabidopsis thaliana TIFY10B/JAZ2, TIFY11A/JAZ5, TIFY11B/JAZ6, TIFY5A/JAZ8, TIFY9/JAZ10 and TIFY3B/JAZ12), thereby activating host jasmonate signaling (PubMed:24204266, PubMed:27525589).
What are the official names of this protein?
Serine/threonine-protein acetyltransferase HopZ1a, Protein orf34.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase YopJ family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane. Host cytoplasm, host cytoskeleton. Host nucleus. Note=Secreted via type III secretion system (TTSS).
Protein: F166C_BOVIN
Sequence: MASRSAGTLLTEFNAAYVPPGLMPGYKGHVPGVAFSFGSPYGTTTLKYFQDQRNAALGRSSTAFSRGGHFPTIFSLNPTQVLRNRALTRDRWLHTPSYTRFNLDSSRWAELLHFYQMAQRHREHYQDKTGLVHRVPYFVLPVKEWDRYPIPTDLPPLSPKEKWHLLRVAPENLRTYQTFPSGKRVSPQERQRRDCYFEFRA
What are the official names of this protein?
Protein FAM166C.
What is the protein family that this protein belongs to?
Belongs to the FAM166C family.
Protein: IPYR2_HUMAN
Sequence: MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
What is the function of this protein?
Hydrolyzes inorganic pyrophosphate (PubMed:27523597).  This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598).
What are the official names of this protein?
Inorganic pyrophosphatase 2, mitochondrial, Pyrophosphatase SID6-306, Pyrophosphate phospho-hydrolase 2, PPase 2.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: YCIZ_ECO5E
Sequence: MSEFDAQRVAERIDIVLDILVADDYHSAIHNLEILKAELLRQVAESTPDIPKAPWEI
What are the official names of this protein?
UPF0509 protein YciZ.
What is the protein family that this protein belongs to?
Belongs to the UPF0509 family.
Protein: CLC1_ORYSJ
Sequence: MASFFADDGADELPRTASHPFDADDDAAPDASGGAAADDTGYGGYASFVDGGVEDVEEEEEEIAVESEGVPIGHVSGGFSPSPFSPDPELDGGDGPILPPPAQMGAEEGILLREWRRQNAIVLEEKERKEKELRAQILAEAEEFKKAFYEKRIQNCETNKVHNREREKIFVAGQEKFHAEADKQYWKSISELIPHEIATIEKRGKKDKDKKPSITVIQGPKPGKPTDLSRMRQILVKLKHAPPPHMMQPPPASAAKDGAKDGAKDGTPAPANGTKKPAESKEKPANGSPAEAEKEQPAASE
What is the function of this protein?
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
What are the official names of this protein?
Clathrin light chain 1.
What is the protein family that this protein belongs to?
Belongs to the clathrin light chain family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.