PharMolix/UniProtQA huggingface dataset:
Protein: HAUS8_XENLA
Sequence: MSEAGVAPIEDGSQNSSGGSSGDAALKKSKGGAKVVKSRYMQIGRSKVSKNSLANTTVCSGGKVPERGSGGTPTRRSLAPHKAKITAAVPLPALDGSIFTKEDLQSTLLDGHRIARPDLDLSVINDRTLQKITPRPVVTSEQKKPKRDTTPVNLVPEDMVEMIESQTLLLTYLTIKMQKNLFRLEEKAERNLLLVNDQKDQLQETIHMMKRDLTLLQREERLRDLIEKQDEVLTPVVTSKDPFKDNYTTFATALDSTRHQLAIKNIHITGNRHRYLEELQKHLAITKSLLEEIMPSHASENAESFDTIKDLENIVLKTDEELARSFRQILDLSFKVNKEISLQSQKAVEETCESALVRQWYFDGSLP
What is the function of this protein?
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
What are the official names of this protein?
HAUS augmin-like complex subunit 8, HEC1/NDC80-interacting centrosome-associated protein 1, Sarcoma antigen NY-SAR-48 homolog.
What is the protein family that this protein belongs to?
Belongs to the HAUS8 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, primarily cytoplasmic and associates with centrosomes and with the mitotic spindles, preferentially at the spindle pole vicinity. During anaphase and telophase, additionally associates with the spindle midzone and midbody, respectively. Localizes to mitotic spindle microtubules (By similarity).
Protein: TS57_MYCTU
Sequence: MRNVRLFRALLGVDKRTVIEDIEFEEDDAGDGARVIARVRPRSAVLRRCGRCGRKASWYDRGAGLRQWRSLDWGTVEVFLEAEAPRVNCPTHGPTVVAVPWARHHAGHTYAFDDTVAWLAVACSKTAVCELMRIAWRTVGAIVARVWADTEKRIDRFANLRRIGIDEISYKRHHRYLTVVVDHDSGRLVWAAPGHDKATLGLFFDALGAERAAQITHVSADAADWIADVVTERCPDAIQCADPFHVVAWATEALDVERRRAWNDARAIARTEPKWGRGRPGKNAAPRPGRERARRLKGARYALWKNPEDLTERQSAKLAWIAKTDPRLYRAYLLKESLRHVFSVKGEEGKQALDRWISWAQRCRIPVFVELAARIKRHRVAIDAALDHGLSQGLIESTNTKIRLLTRIAFGFRSPQALIALAMLTLAGHRPTLPGRHNHPQISQ
What are the official names of this protein?
Transposase for insertion sequence element IS1557.
What is the protein family that this protein belongs to?
Belongs to the transposase 12 family.
Protein: VIRD4_RHIRD
Sequence: MNSSKTSPQRMTLSIVCSLAAGFCAASCYVTFRRGFNGEAIMTFDVFAFWYETPLYLGYASTVFWRGLSVVIFTSLAVLSSQLIISLRNQKHHGTARWAEIGEMQHAGYLQRYSRIKGPIFGKTCGPLWFGSYLTNGEQPHSLVVAPTRAGKGVGIVIPTLLTFKGSVIALDVKGELFELTSRARKASGDAVFKFSPLDSERKTHCYNPVLDIATLPPERQFTETRRLAANLITAKGKGAEGFIDGARDLFVAGILTCIERGTPTIGAVYDLFAQPGEKYKLFAQLAEESLNKEAQRIFDNMAGNDTKILTSYTSVLGDGGLNLWADPLIKAATSRSDFSVYDLRRKKTCIYLCVSPNDLEVLAPLMRLLFQQLVSILQRSLPGKDECHEVLFLLDEFKHLGKLEAIETAITTIAGYKGRFMFIIQSLSALTGTYDDAGKQNFLSNTGVQVFMATADDETPTYISKAIGEYTFKARSTSYSQASMFDHNIQISDQGAALLRPEQVRLLDDQSEIVLIKGRPPLKLRKVQYYSDRTLKRLFERQMGSLPEPAPLMLSDYSNDQVQSHLAEIANFNEDAAPRNRTVAEDHGSVKVGADIPERVMGINGDEDQADAREIPPELGCASRIDAGSGRSTAIVGPDYCTSAKIEVRTGTACEMKLNWVQFVSGGMLRFDKVYARSQLSLYEVSV
What are the official names of this protein?
Protein VirD4.
What is the protein family that this protein belongs to?
Belongs to the VirD4/TraG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBIA_ECO55
Sequence: MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSIVVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MALT_SALPB
Sequence: MLIPSKLSRPVRLDHTVVRERLLAKLSGANNFRLALVTSPAGYGKTTLVSQWAAGKNELGWYSLDEGDNQQERFASYLIAAIQQATGGHCSTSEAMAQKRQYASLTSLFAQLFIELAQWHRPLYLVIDDYHLITNPVIHDAMRFFLRHQPENFTLVVLSRNLPQLGIANLRVRDQLLEIGSQQLAFNHQEAKQFFDRRLSSPIEAAESSRMCDDVAGWATALQLIALSARQNHTSAHHSARRLAGINASHLSDYLVDEVLDNVDVSTRHFLLKSAILRSMNDALIVRVTGEENGQMRLEEIERQGLFLQRMDDTGEWFSYHPLFGSFLRQRCQWELAAELPEIHRAAAESWMEQGFPSEAIHHALAAGDAQMLRDILLNHAWGLFNHSELALLEESLKALPWESLLENPRLVLLQAWLMQSQHRYSEVNTLLARAEQEIKGVMDGTLHAEFNALRAQVAINDGNPEEAERLAKLALDELPLAWFYSRIVATSVHGEVLHCKGDLSQSLSLMQQTEQMARHHDVWHYALWSLIQQSEIQFAQGFLQAAWETQERAFQLIKEQHLEQLPMHEFLVRIRAQLLWAWARLDEAEASARSGIAVLSTFQPQQQLQCLTLLVQCSLARGDLDNARSQLNRLENLLGNGRYHCDWISNADKVRVIYWQLTGDKKSAANWLRHTPKPAFANNHFLQGQWRNIARAQILLGEFEPAEIVLEELNENARSLRLMSDLNRNLLLLNQLYWQSGRKNDAQRVLLDALQLANRTGFISHFVIEGEAMAQQLRQLIQLNTLPEMEQHRAQRILREINQHHRHKFAHFDEGFVERLLNHPDVPELIRTSPLTQREWQVLGLIYSGYSNEQIAGELAVAATTIKTHIRNLYQKLGVAHRQDAVQHAQQLLKMMGYGV
What is the function of this protein?
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides.  Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
What are the official names of this protein?
HTH-type transcriptional regulator MalT, ATP-dependent transcriptional activator MalT.
What is the protein family that this protein belongs to?
Belongs to the MalT family.
Protein: Y1352_MYCBO
Sequence: MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIPRFLFAVSFCGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR
What are the official names of this protein?
Uncharacterized protein Mb1352c.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-3 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAPA_METMJ
Sequence: MFEGILPAIITPFYRDSRASLDIEGLQSNIESLLQRGVHGIVPCGSTGESATLTFEEHEQVIGKAVEVVDGRVPVLAGTGSNNTEEAVRLTRSAKDAGADGALIISPYYNKPNRSGLIKHFTKLADLDIPIVLYNVPGRTGQNLQPDLVAELARHPNIVGIKEASGDITQISRIIEETRDEEFSVISGDDAMTLPVLAVGGAGVISVAANVDPGRMVGMYEAFRAGDLARAQVLHYELAPLMRAMFIDTNPIPVKKAVELLGMAAGPVRLPLDELDEAKTEQLRKVLVNHG
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_RHOPB
Sequence: MRCPSCSSLDTQVKDSRPTEDSAVIRRRRVCMACNFRFTTFERVQLRELTVIKRNGRRVPFDRDKLVRSVQISLRKRPVEPEKVEKMVSAIVRELESAGEAEISSEAIGEIVMEHLRKLDDVAYVRFASVYRNFREAKDFEAVLGELSGDEMARLAALRLK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: DFA15_MOUSE
Sequence: MKTLVLLSALVLLAFQVQADPIQNTDEETKTEEQPGEDDQAVSVSFGDPEGSSLQEESLRDLVCYCRKRGCKRREHINGTCRKGHLLYMLCCR
What is the function of this protein?
Probably contributes to the antimicrobial barrier function of the small bowel mucosa.
What are the official names of this protein?
Alpha-defensin 15, Defensin-related cryptdin-15.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNMG_SYNWW
Sequence: MIYKAGSYEVIVIGAGHAGCEAALASARMGCQTLLVTMSIDHIALMPCNPSIGGPAKAQVVREIDALGGEMALNIDKANVQIRTINTGKGPAVQALRAQADKRQYHLEMLKTLFNQKKLDILMAEVEDIELSAGRVKAIVTRTGARFECQALVLTTGTYLKGRIIVGDISFDGGPGNQFPAARLSESLKRMGLRLGRFKTGTPPRIDSKSVDFSKMIEQPGDKRPLRFSFISPLINRPQLPCWLTHSNKKTHQIVMNNLDRAPMYTGIIKGIGTRYCPSFEDKVVRFSHKDSHQLFIEPEGRDTDEMYVQGLNTSLPEDVQIEVLKSIPGLENVRIMRTGYAIEYDIIYPSQLKLSLECKTVEGLFTAGQINGTSGYEEAAAQGLIAGINAALQVKEKEPFILKRSEAYIAVMIDDLINKEIVEPYRLLTSRAEYRLLLRQDNADLRLTEKGRQIGLVDDNRWMAYQQKEEILEVESNELKFSSFTPADEEMADFLSGKNTAAIRDRVSLWELLRRPELSIYDYVEKGWLRDNDPDILEQLEIQAKYEGYIEKQKEQVKRFEKLENKMIPPDINYDEVYGLSQEAVQKLKIILPASVGQASRIAGVNPADINVLLIFLEKKRRK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_MYCTA
Sequence: MALEMFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQGLDVDTPAEVAKWADVVMVLAPDTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADVAVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLALALSYAKAIGGTRAGVIKTTFKDETETDLFGEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEVLHELKLIVDLMYEGGLARMYYSVSDTAEFGGYLSGPRVIDAGTKERMRDILREIQDGSFVHKLVADVEGGNKQLEELRRQNAEHPIEVVGKKLRDLMSWVDRPITETA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SYS_CHLP8
Sequence: MLDISYIRQNPEEVKEMLRRRQQSDDAPKVDRLLERDAERKAMVQRTDDLKALRNRVSKEIANIKRTGQGSGEELISQMKEVSDQIADLDLGLSTLEGEIEELLLTLPNKLHESVPEGRSADENILYKGPVSFEHNLDFPVKDHLELGKSLGLLDFERGAKITGAGFPVYTGKGARLERALINFMLDTHSANHGYTEVFPPFMVNKESLRGTGQWPKFADQVYHMPEDGLYAIPTAEVPVTNLHRGEMLEDDKLPIAYAAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVRFTRPEKSYEALEEILSHAEAILCALKIPYRVITLCSGDISANAAKCYDIEVWSPAENKYLEASSVSNFEDYQARRSNIRFKPGGKGKPEFVHTLNGSGLATSRLMVSLLEHYQTADGKIMVPEVLRPYTGFDVIE
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH60_YERPG
Sequence: MAAKDVKFGNDARIKMLRGVNILADAVKVTLGPKGRNVVLDKSFGSPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIITEGLKAVAAGMNPMDLKRGIDKAVIAAVEELKKLSVPCSDSKAIAQVGTISANSDSTVGELIAQAMEKVGKEGVITVEEGSGLQDELDVVEGMQFDRGYLSPYFINKPETGSIELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTAGTVISEEIGLELEKTTLEDLGQAKRVVINKDTTIIIDGVGDEAAIQGRVAQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRAAHAIAGLKGDNEDQNVGIKVALRAMESPLRQIVVNAGEEASVIANKVKAGEGSFGYNAYTEEYGDMIAMGILDPTKVTRSALQYAASIAGLMITTECMVTDLPRDDKGADMGAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARF_MONDO
Sequence: MIRRVRVTVRVSRACRPHHVRIFVAKIVQALCRASASINQGTPFQVLLIVRKKRHRGRSGHDDGQCTPGSNPVAVRGGTQHPRPDNPHPASPRRCPGGLPGHSDAAPSGRGAAGCQGLLGSPACGPRRGTRTPPRGRIPARGGEGRLNDTVQEAQ
What is the function of this protein?
Capable of inducing cell cycle arrest in G1 and G2 phases.  Acts as a tumor suppressor.  Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus.  This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis.  Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.  Binds to BCL6 and down-regulates BCL6-induced transcriptional repression.  Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression.  Binds to TOP1/TOPOI and stimulates its activity.  This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation.  Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing.  Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity).  Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination.  Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1.  Binds to HUWE1 and represses its ubiquitin ligase activity.  May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity).
What are the official names of this protein?
Tumor suppressor ARF, Alternative reading frame, ARF, Cyclin-dependent kinase inhibitor 2A, p19ARF.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: RSMH_SYNFM
Sequence: MEPGPALEHIPVMLEQALELLACRRGGVYVDGTVGGGGYSEAILRASAPDGILLGVDWDAEAIGRAAGRLSAYGRRAILTKAGFAELPEVLPRHGFAQVDGIVLDLGVSAFQIDDAARGFSFTKDGPLDMRMDPGLPQTAADMVNTLPEKDLADLIFRLGEERWSRRIARAVVERRRERPFQRTLELADTVAATVPATRDSRRIHPATRTFLALRLAVNQELESLERFLSGALDLLKTGGRLCVVSFHSLEDRMVKGQFKEWAKSCRCPREAVLCRCEGRPLVRLLTRKAVRPDEREKERNPRSRSARLRAVEKQGVPA
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y836_ARCFU
Sequence: MEKIKKFLIQLLNMRARNTVDIIASIVGAVIIAAAISALLFSIASFLGFYSKDLSPLVYSIVSLAVIPVLRRNVPKKPILSLLTAFSIPILFLSGVEWLKLVASVLLGYLAASSLKDS
What are the official names of this protein?
Uncharacterized protein AF_0836.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TDH_BURP0
Sequence: MKALAKLERGPGLTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFSIGDRVSGEGHITCGFCRNCRAGRRHLCRNTVGVGVNREGAFAEYLAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVLITGAGPIGVMAVAIAKHVGARNVVITDINDYRLELARKMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMSGVPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAMLQSGLDLSPIITHRFAVDDYEKGFAAMLSGESGKVILDWADA
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_THIDA
Sequence: MSVDKEFLASLPTLPGVYRMVDAAGAVLYVGKAKDLRKRVGSYFLKTDQSPRIRLMLKSVDHIDTTVTRTEAEALLLENNLIKGLKPRFNILFRDDKSYPYLLLTGHGYPRLAYFRGAPKKRDQAFGPYPNSYAVRESIQLLQKVFQLRTCEDTVFGNRSRPCLLHQIKRCSAPCVSLVSAETYARDVAEAMLLLKGEATALTEEITAQMNAAAENLDFETAAYLRDRLRMLATVREKQFVDTTGSEADADVVAVAEVGGVIAVNLTMIRGGRHLGDRSFFPQHGEGAALGEALEAFVAQHYLDHPIPARILVSEAIDSAALQTLLSEQAGKKVTLQHRVTGERRVWIAMAQANARLSAERRSADRANQSQRLAALRDTLELPTLNRIECFDISHTMGEATIASCVVYEGDDLKKSDYRRYNIEGITPGDDYAAMHAALIKRFHRTVEENGVLPDLLLIDGGKGQVAMAVEALAELGIDDVLLLGVAKGESRKPGLETLIFADGRELKLARDHPGFHLIQQVRDEAHRFAITGHRAKRGKARVQSTLEDIAGIGPKRRKQLLEHFGGLQGVRNAGVDALASVNGISRELAEIIYNALH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_RHIEC
Sequence: MKLPKAIGLVHFIGIGGIGMSGIAEVLHNLGHKVQGSDQSDSANVQRLREKGIEVFVGHRAENLGDAEVVVVSTAIRKSNPELIAAREKLLPVVRRAEMLAELMRFRNAIAIGGTHGKTTTTSLVATLLEAGGLDPTVINGGIINAYGTNARMGEGEWMVVEADESDGTFLKLPADVAVITNIDPEHLDHYGNFDAVRAAFRQFVENVPFYGFGVMCLDHPEVQSLVGRIEDRKIITYGENPQADVRFKNVRIDGTRSIFDVEIRRRRTGQRTELKGLVMPMPGRHNISNATAAIAVANRLGISSEDIAKGLASFGGVKRRFTLTGEWNGVQIFDDYGHHPVEIKAVLKAAREACKGRIIAVHQPHRYTRLASLFEEFAACFNDADSILLAPVYAAGEDAIEGVDSTSLVSRIKSGGHRDARFLSSAELLPEMVAEVAKPGDFVVLLGAGSITSWAAALPKQLEGLSGKSA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPB_ACIF5
Sequence: MGTYALPDAFGHYGPYGGRFVAETLIPALEELERAYQEAQRDPEFRAELHSELRQFVGRPNPLYHAGRLSRELGGAQIYLKREDLNHTGAHKINNAVGQALLARRMGKKRVIAETGAGQHGVATATVATRYGMECLVYMGEEDIQRQSSNVFRMRLLGAQVTAVSSGTRTLKDALNEALRDWVTNVESTFYVIGTVAGPHPYPVMVRDFHRVIGDEARAQCLELTGRLPDCLIACVGGGSNAIGLFYPFIEDRAVRMIGVEAGGLGLGTGQHAAPLTTGRPGVLHGNRTYLMEDEDGQILPTHSISAGLDYPGVGPEHAYLKDTGRAEYVAATDEEALAAFHRLCRTEGIIPALESAHALAHAFRLAPTMRSDQTIIVNLSGRGDKDIHTVAALEGIHL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: PYRF_ACIAC
Sequence: MTFIDMLRGATARNDSLLCVGLDPEPSRFPAGLRGDAGRIYDFCAAIVDATADLACAFKPQIAYFAAHRAEEQLERLMRHMRATAPHVPVILDAKRGDIGSTAQQYAIEAFERYGADAVTLSPFMGFDSIEPYLAYHGKGAFLLCRTSNPGGDDLQSQRLASVDGQPLLFEHIARQAQGPWNRNGQLGLVVGATYPAEIERVRALAPTLPLLIPGVGAQGGDAAATVRAGLRPDGPVVVNSSRAILYASADEGFAAAARQAAQATRDALNAARG
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: SC5A2_RABIT
Sequence: MEEHMEAGSRLGLGDHGALIDNPADIAVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAANGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMVYTVTGGLAALMYTDTVQTFVIIAGAFILTGYAFHEVGGYSGLFDKYMGAMTSLTVSEDPAVGNISSSCYRPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGRNLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVAPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTLRPRAGEGELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVVALFVPRVNEKGAFWGLIGGLLMGLARLIPEFSFGTGSCVRPSACPAFLCRVHYLYFAIVLFFCSGLLIIIVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADELEAPASPPVQNGRPEHAVEMEEPQAPGPGLFRQCLLWFCGMNRGRAGGPAPPTQEEEAAAARRLEDINEDPRWSRVVNLNALLMMAVAMFFWGFYA
What is the function of this protein?
Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1.  Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity).  Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
What are the official names of this protein?
Sodium/glucose cotransporter 2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter, Solute carrier family 5 member 2.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: RCC1_CANAX
Sequence: MFVLHSYSKLPNINEYAKAKSTPLDVFVWGTGSMCELGLGPSAKNKEVKRPRLNPYLTEEKLGGTKIVDFAVGGMHTLALDGKNRIWSWGGNDSEVLGRDTCQAKEVLKDIDGKNGNDDDDDDEDGDLNEAESTPALVENLPEGEIVQLAATDNLSAALLSNGDVYSWGCFRCNEGLLGFLRDEIKLQKTPLKIKELKKHCPIMRSVKIILLALDSKEWMPGVNGQQYQLGRRILERHRYRSLEPQQFGLYNIKYIASGDFHCFAIDHSHNVYAWGLNQYGQCALTGDNGELEDGSVLMKPTLIPELSHKGIKEIAAGEHHTLALTEDGQVYAWGRYDMKEIGIPKDKLPKSTFKINTGTHGSFSFLQNLFAVKIKTIGVGSHHSFAVTEDGVVYAWGFAETYGPGLGPSIDDVEKPTRIVNTATKNEDILLIGAGGQFSVSGGVKFEDEEKAEVRLDKYEDLE
What is the function of this protein?
Promotes the exchange of Ran(SPI1)-bound GDP by GTP.  Involved in the control of mitosis.  Regulates a variety of nuclear events, including mitotic check-point, chromosome decondensation and mRNA processing/transport (By similarity).
What are the official names of this protein?
Protein RCC1.
What are the subcellular locations of this protein?
Nucleus.
Protein: SMS_MOUSE
Sequence: MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATGKQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
What is the function of this protein?
May enhance low-glucose-induced glucagon release by pancreatic alpha cells (PubMed:24735892).  This effect may be mediated by binding to GPR107 and PKA activation (PubMed:26561648).  May regulate cardiac contractile function (PubMed:25012062).  May compromise cardiomyocyte viability (By similarity).  In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity).  May also have anxiolytic and anorexigenic effects (By similarity).  May play a role in arterial pressure regulation (By similarity).  May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH (By similarity).  Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity).
What are the official names of this protein?
Somatostatin.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.