PharMolix/UniProtQA huggingface dataset:
Protein: PURT_MYCA9
Sequence: MTTIGTPLSPRATRVMLLGSGELGREVLIALQRLGVETIAVDRYENAPGHQIAHHARVISMTDPEQLRALIEAEKPDLVVPEIEAIATATLEALETEGVVRVIPTARAARLTMDREGIRRLAAETLGLPTSPYQFCGSLDELQAAIDPESGGVGYPCVVKPLMSSSGKGQSKLDGPADVEKAWDYAMAGSRVTNNRVIVEGFVDFDYEITLLTVRALGDDGEVETSFCAPIGHRQANGDYVESWQPHPMTEAALRSAQHIARSVTENLGGQGIFGVELFIKGDQVYFSEVSPRPHDTGMVTMITQWQNEFELHARAILGLPVDTTLKSAGASAVIYGGVEAQGVVFDGVDEALRVPRTELRLFGKPESFITRRMGVALARDEDVDTARRNAAEAAGRVRVSG
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: MENC_VIBCM
Sequence: MRHATLYRYQLPMDSGVILRNEKLTQREGFIVELTENGRTARGEIAPLPGFSRETLEDAGLQAQALLEQWVKGHAIEWDAQHPSVAFGLSMAHYELEQALPEQGNYYVAPLCTGDPDELLPVLNNLPGQKVAKVKVGLYEPIRDGMLVNLFLESMPDLTLRLDANRAWTPAKALKFAQYVAPSLRSRIAFLEEPCQSPSESIAFSIDTGIAIAWDETLQEAVRDADFALENLLGVKTIVIKPTLIGSVYRVEALIEKAKTLGLQAVISSSLESSLGLNQLARLAHKLLPNEVPGLDTIGLFRAQLETPWPNSSLPVVALQEQSIVWRSESSL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: NANA_STAAW
Sequence: MNKDLKGLYAALLVPFDENGQVNEQGLKQIAQNAIETEELDGLYVNGSSGENFLLNTEQKKQVFKVAKEAVGDKVKLIAQVGSLDLNEAIELGKYATELGYDALSAVTPFYYPFTFEEIRDYYFDIIEATQNNMIIYAIPDLTGVNISIEQFSELFNHEKIVGVKYTAPNFFLLERIRKAFPDKLILSGFDEMLVQATISGVDGAIGSTYNVNGRRARKIFDLARQGQIQEAYQLQHDSNDIIETVLSMGIYPTLKEILRHRGIDAGLPKRPFKPFNEAHRQTLDQLIAKYDL
What is the function of this protein?
Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
What are the official names of this protein?
N-acetylneuraminate lyase, NAL, Neu5Ac lyase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase, Sialic acid aldolase, Sialic acid lyase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. NanA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: T225B_HUMAN
Sequence: MLTLEDKDMKGFSWAIVPALTSLGYLIILVVSIFPFWVRLTNEESHEVFFSGLFENCFNAKCWKPRPLSIYIILGRVFLLSAVFLAFVTTFIMMPFASEFFPRTWKQNFVLACISFFTGACAFLALVLHALEIKALRMKLGPLQFSVLWPYYVLGFGIFLFIVAGTICLIQEMVCPCWHLLSTSQSMEEDHGSLYLDNLESLGGEPSSVQKETQVTAETVI
What are the official names of this protein?
Transmembrane protein 225B.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HBB_ARAAR
Sequence: VHWTAEEKQLITGLWGKVNVADCGAEALARLLIVYPWTQRFFASFGNLSSPTAILGNPMVRAHGKKVLTSFGEAVKNLDNIKNTFAQLSELHCDKLHVDPENFRLLGDILIIVLAAHFGKDFTPECQAALQKLVRVVAHALARKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: ENG1_HALH5
Sequence: MKGKNVQLLFALVVIILLFPTGASASPHAVSVGKGSYATEFPEIDFGGINDPGFRDQQGEPPATIYRSDRVTGPMQTNSWWGSLAVDRFSMNQYPHPFSVRHRAEGLHVFYDAPHNMVVHENREAGTWHIHGAIGTDFTIKHSGTANFEQAVVDDYNDWYVRGLLENGAHQMAITYGVGSPYIFVEYEDGSAVLDFDIAPDVWEMNGHVIGFSTHDHKHYAAFAPPGQNWSGIGSKTLTNNADYIAIAKLPEKDGNMLAKFEQYAYSVVRDAVADWTYDEATGTVTTTFEVTTEAKVQGAPDGTIFALYPHQYRHLASSSENQLLQNYQYEIIRGTMIGLEGKRFTTELTYPGVLPSLPDLGDYDRERLIGYLHDATSDYPTGSDTYELGKYIGKLATLAPIADQMGEYELAEQFRGELKDILEDWLQATNASGQLKGKNLFYYNENWGTILGYHAAHSSATRINDHHFHYGYFVKAAAEIARADQEWAKSENWGGMIDLLIRDFMADRDDDLFPYLRMFDPYSGNSWADGLATFDAGNNQESSSEAMHAWTNVILWAEATGNKALRDRAIYLYTTEMSAINEYFFDVHQEIFPEEYGPEIVTINWGGKMDHATWWNSGKVEKYAINWLPFHGGSLYLGHHPDYVDRAYEELRRDIGSTDWNLWSNLVWMYRAFTNPDDALQQMEASIDDYGLFDPGNEKIIERGSTKAQTYHWIHNLAELGRVDPTVTANHPIYAVFNKNGNRTYIVYNFSDSPITVQFSDGHSIQVEPHSFNIGNGDGPTNPDPSEPDLKNPYERIQAEAYDAMSGIQTEGTDDDGGGDNIGWINDGDWVKYERVHFERDASSIEVRVASDTPGGRIEIRTGSPTGTLLGDVQVPNTGGWQQWQTVTGNVQIQPGTYDVYLVFKGSPEYDLMNVNWFVFRANGQGNGDSHTHPDYTAGIRGITGNEVTIFFAPTTEARYVDVHLKVNNGQQLNYRMTERNGEWERVVENLSSGDVLEYSFTYEKLGPQYTTEWFTYSR
What is the function of this protein?
Cleaves internal linkages in 1,3-beta-glucan (PubMed:15501830, PubMed:28827308, PubMed:28781080).  May contribute to plant biomass degradation (By similarity).
What are the official names of this protein?
Glucan endo-1,3-beta-D-glucosidase, Endo-1,3-beta-glucanase, Laminarinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 81 family.
Protein: CONA_CANBR
Sequence: ADTIVAVELDTYPNTDIGDPSYPHIGIDIKSVRSKKTAKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPEWVRVGLSASTGLYKETNTILSWSFTSKLKSNSTHETNALHFMFNQFSKDQKDLILQGDATTGTEGNLRLTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVASFEATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDAN
What is the function of this protein?
Glucose/D-mannose specific lectin.  Has anti-inflammatory activity in rats.  Induces histamine release in mast cells from hamster and rat.  Induces lymphocyte proliferation and IFNG production.  Shows toxicity against the aquatic snail B. glabrata at concentrations higher than 20 ug/ml.
What are the official names of this protein?
Concanavalin-Br, Con Br.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: RS18_STAAN
Sequence: MAGGPRRGGRRRKKVCYFTANGITHIDYKDTELLKRFISERGKILPRRVTGTSAKYQRMLTTAIKRSRHMALLPYVKEEQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: ACPS_CAMJJ
Sequence: MRVGCDIIAISRIEKIHSRHGKNFLDKFLSPKEQILIKNPATLAGLWAAKEAASKALGVGICELCSFFDIEISKDEKNAPKLKYSQKITKDFNITQTSLSISHDNGFAIAIVAIV
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ODO2_STAHJ
Sequence: MPEVKVPELAESITEGTIAEWLKNVGDSVEKGEAILELETDKVNVEVVSEEEGVLQEQLASEGDTVEVGQVIATVGEGSGNASSSKEESSDQSQSANNDEATKELAQPTESQSNNEETQSNPNNQRVNATPSARRHARENGVDLSTVSGKGNDVVRKDDVENSQKAAQSQSSQETSKKEEPKKSSGAPNKPVIREKMSRRKKTAAKKLLEVSNNTAMLTTFNEVDMTNVMELRKRKKEQFIKDHDGTKLGFMSFFTKAAVAALKKYPEVNAEIDGDDMITKQYYDIGVAVSTDDGLLVPFVRDCDKKNFAELERAIADLAVKARDKKLGLDDMVNGSFTITNGGVFGSMMSTPIINGNQAAILGMHSIITRPIAIDKDTIENRPMMYIALSYDHRIIDGKEAVGFLKTIKELIESPEDLLLES
What is the function of this protein?
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, 2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex.
What is the protein family that this protein belongs to?
Belongs to the 2-oxoacid dehydrogenase family.
Protein: RL16_DEIRA
Sequence: MLLPKRTKFRKQFRGRMTGDAKGGDYVAFGDYGLIAMEPAWIKSNQIEACRIVMSRHFRRGGKIYIRIFPDKPVTKKPAETRMGKGKGAVEYWVSVVKPGRVMFEVAGVTEEQAKEAFRLAGHKLPIQTKMVKREVYDEAQ
What is the function of this protein?
Binds the 5S and 23S rRNAs and is also seen to make contacts with the A and P site tRNAs.  Interacts with A site tRNA mimics, and is probably one of the key factors, along with a helix of the 23S rRNA, in positioning tRNA stems in the peptidyl-transferase center.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: AZOR1_RHIEC
Sequence: MSSILLLTSSPRAESLSTPIAADLAEKLKNQKPGSVVVRRDLAATPLPHIDDLFTGAIRKPAEARTAEEIAAVKTSDELVAELFAADTIVISTGLINFNIYSSLKTWIDNVARAGVTFKYTESGPVGLVTGKKVYVVLASGGVYSQGPAAPLNHAVPYLKSVLGFLGITDIETIYVEGLAFGPEAAEKAIGAAKSRVEEIALAA
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase 1, Azo-dye reductase 1, FMN-dependent NADH-azo compound oxidoreductase 1, FMN-dependent NADH-azoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: PME18_ARATH
Sequence: MSNSNQPLLSKPKSLKHKNLCLVLSFVAILGSVAFFTAQLISVNTNNNDDSLLTTSQICHGAHDQDSCQALLSEFTTLSLSKLNRLDLLHVFLKNSVWRLESTMTMVSEARIRSNGVRDKAGFADCEEMMDVSKDRMMSSMEELRGGNYNLESYSNVHTWLSSVLTNYMTCLESISDVSVNSKQIVKPQLEDLVSRARVALAIFVSVLPARDDLKMIISNRFPSWLTALDRKLLESSPKTLKVTANVVVAKDGTGKFKTVNEAVAAAPENSNTRYVIYVKKGVYKETIDIGKKKKNLMLVGDGKDATIITGSLNVIDGSTTFRSATVAANGDGFMAQDIWFQNTAGPAKHQAVALRVSADQTVINRCRIDAYQDTLYTHTLRQFYRDSYITGTVDFIFGNSAVVFQNCDIVARNPGAGQKNMLTAQGREDQNQNTAISIQKCKITASSDLAPVKGSVKTFLGRPWKLYSRTVIMQSFIDNHIDPAGWFPWDGEFALSTLYYGEYANTGPGADTSKRVNWKGFKVIKDSKEAEQFTVAKLIQGGLWLKPTGVTFQEWL
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.  Inhibits the elongation phase of protein synthesis.
What are the official names of this protein?
Pectinesterase/pectinesterase inhibitor 18, AtPMEpcrA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: COMS_BACSU
Sequence: MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWREK
What is the function of this protein?
Required for the development of competence.
What are the official names of this protein?
Competence protein S.
Protein: NGFV2_TROCA
Sequence: MSMLCYTLIIAFLIGTWAAPKSEDNVPLGSPATSDLSDTSCAQTHEGLKTSRNTDQRHPAPKKAEDQELGSVANIIVDPKLFQKRRFQSSRVLFSTQPPPLSRDEQSVEFLDNEDTLNRNIRAKRENHPVHNQGEHSVCDSVSDWVIKTTATDIRGNVVTVMEDINLNNEVYKQYFFETKCRNPSPNPVQSECRGIDSRLWNSYCTTTQTFVRALTMEGNQASWRFIRIDTACVCVIIRKTDNF
What is the function of this protein?
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems.  It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain.  Its relevance in the snake venom is not clear.  However, it has been shown to inhibit metalloproteinase-dependent proteolysis of platelet glycoprotein Ib alpha, suggesting a metalloproteinase inhibition to prevent metalloprotease autodigestion and/or protection against prey proteases (By similarity).  Binds a lipid between the two protein chains in the homodimer.  The lipid-bound form promotes histamine relase from mouse mast cells, contrary to the lipid-free form (By similarity).
What are the official names of this protein?
Venom nerve growth factor 2, v-NGF-2, vNGF-2.
What is the protein family that this protein belongs to?
Belongs to the NGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOC_BURMS
Sequence: MASKIETLKANLEAALGARAVSLVEAVGELTLVVKASDYLEVAKQLRDDRSLGFEQLIDLCGVDYQTYGDGAYDGPRFAAVLHLLSVANNWRLRVRVFASDDDLPIVPSVVDIWNSANWYEREAFDLYGIVFEGHPDLRRILTDYGFIGHPFRKDFPVSGYVEMRYDPQEKRVVYQPVTIEPREITPRVIREDRYGGLKH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACPS_STRP7
Sequence: MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLSISHTDQFVTASVILEENHES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKA1_ARATH
Sequence: MSAGNGNATNGDGGFSFPKGPVMPKITTGAAKRGSGVCHDDSGPTVNATTIDELHSLQKKRSAPTTPINQNAAAAFAAVSEEERQKIQLQSISASLASLTRESGPKVVRGDPAEKKTDGSTTPAYAHGQHHSIFSPATGAVSDSSLKFTHVLYNLSPAELYEQAIKYEKGSFITSNGALATLSGAKTGRAPRDKRVVRDATTEDELWWGKGSPNIEMDEHTFMVNRERAVDYLNSLEKVFVNDQYLNWDPENRIKVRIVSARAYHSLFMHNMCIRPTQEELESFGTPDFTIYNAGQFPCNRYTHYMTSSTSVDLNLARREMVILGTQYAGEMKKGLFSVMHYLMPKRRILSLHSGCNMGKDGDVALFFGLSGTGKTTLSTDHNRYLIGDDEHCWTETGVSNIEGGCYAKCVDLSREKEPDIWNAIKFGTVLENVVFDEHTREVDYSDKSVTENTRAAYPIEFIPNAKIPCVGPHPTNVILLACDAFGVLPPVSKLNLAQTMYHFISGYTALVAGTEDGIKEPTATFSACFGAAFIMLHPTKYAAMLAEKMKSQGATGWLVNTGWSGGSYGVGNRIKLAYTRKIIDAIHSGSLLKANYKKTEIFGFEIPTEIEGIPSEILDPVNSWSDKKAHKDTLVKLGGLFKKNFEVFANHKIGVDGKLTEEILAAGPIF
What is the function of this protein?
Involved in the gluconeogenesis (PubMed:19807880).  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA (PubMed:19807880).
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP) 1, AtPCK1, PEP carboxykinase 1, PEPCK 1.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_THEON
Sequence: MRMLLIHSDYLEYEVKDKALKNPEPISEEQKKGRLEEVLAVFISVEKVDETNPDEVVEKAVNEIKDVASQVKAENVFVYPFAHLSSELAKPDIALEVLREVEEKLREEGFNVKRAPFGYYKAFKLSCKGHPLAELSRTIVPSGEAKAEEEIPEALKKEEEELVSYWYILTPEGELIEVDKFDFTGHENLRKFANYEISKSRIADREPPHVRIMLEQELVDYEPGSDPGNLRYYPKGRLIKGLLEQYVTEKVVEYGAMEVETPIMYDFEHPALEKYLNRFPARQYIVKSGDKKFFLRFAACFGQFLIKKDAIISYRNLPLRMYELTRYSFRREKSGELSGLRRLRAFTMPDMHTVARDLKQAMAEFKKQYKLSMEVLKGVGLTPEDYEVAIRFTEDFWNENRDFIVELAKIIGKPVLIEMWKQRFFYFILKFEFNFVDNLDKAAALSTVQIDVENAERFGITYYDEDGKEKYPLILHCSPSGAIERVMYAILEKQAKLQSKGIKPMFPLWLSPIQVRVIPVSEEVLDYALYVAGKLEGAKIRVDVDDTSDRLNKKIRKAEKEWIPYVIVVGRNEKEQNTITVRRRSDGKQGEMQLEDLIREIRSQTEGFPYKPRPLPLLLSKRPKFRG
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA_ACHLI
Sequence: MTLKDYDLELFNAIQREDNRQKEHIELIASENFVSDAVLEAQGSILTNKYAEGYPNKRYYGGCEFVDQVEILAQDRLKQIFNAKFVNVQPHSGSQANAAVYQALLSPGDRVLGMDLNAGGHLTHGYKLSFSGHYYEAHAYGVSRFDERIDYEEVLKIAIEVKPKMIIAGASAYPRVIDFKKFREIADTVGAYLFVDMAHIAGLVACGLHPSPLPYADVVTSTTHKTLRGPRGGIILTNDASIAKKIDRAVFPGQQGGPLMHIIAAKAVAFKEALDPNFKVYQTQVIKNAKALSDTFKSLGYKLISDGTDNHLILVDVKSKLGITGRDAEDALYKANITINKNQLPFDQEKPMLTSGIRLGTPAMTTKGFKENEFIKVAQLIDEVLSNINNEEVINKVKKEVLKLMKDVK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PINR_ECOLI
Sequence: MSRIFAYCRISTLDQTTENQRREIESAGFKIKPQQIIEEHISGSAATSERPGFNRLLARLKCGDQLIVTKLDRLGCNAMDIRKTVEQLTETGIRVHCLALGGIDLTSPTGKMMMQVISAVAEFERDLLLERTHSGIVRARGAGKRFGRPPVLNEEQKQVVFERIKSGVSISAIAREFKTSRQTILRAKAKLQTPDI
What are the official names of this protein?
Serine recombinase PinR, DNA-invertase PinR, Putative DNA-invertase from lambdoid prophage Rac, Site-specific recombinase PinR.
What is the protein family that this protein belongs to?
Belongs to the site-specific recombinase resolvase family.
Protein: PSD_ALIFM
Sequence: MSDNLKIGLQYLTPKHALTRLAGKLASAKMGWLTTAVIKWFIKQYNVNMDEAKNPDPEAYSTFNNFFVRELEDGARPINEDGSVISHPADACVSQFGPIMDGKLVQAKGHVYSAQELLGGDETLAAEFMGGEFATLYLSPSDYHRVHMPCDATLRKMIYVPGDLFSVNPLTAENVPNLFARNERVVCIFDTEFGPMAQILVGATIVGSIETTWAETVTPPTGPAVKTWHYPLSGDDMICFKKGEEMGRFKLGSTVINLFAPNSIKFDDSMENGIPTRMGTPFAHIVK
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: U519C_DICDI
Sequence: MTIINSISSLGKISNKNKSQANLNSNSTNSPNNVQGLNQNTGLVSSLLELVRGVTFALGLAVESVGL
What are the official names of this protein?
UPF0519 protein C.
What is the protein family that this protein belongs to?
Belongs to the UPF0519 family.
Protein: RS17_CERS1
Sequence: MPKRILQGTVTSDKNEQTVTVLVERRFKHPLLKKTVRLSKKYRAHDPENQFKVGDIVRIEECAPISKTKRWKVVTDAVVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: TM141_BOVIN
Sequence: MVNLGLSRVDDAVASKHPGLGEYAACQSNAFVKGVSTFVTGTGATFGLQMLVQRKLPYPFQWKVLLAVVAGSVASYWVTRVESQKCSNLWLFLETGQLPKDMGTDRRS
What are the official names of this protein?
Transmembrane protein 141.
What is the protein family that this protein belongs to?
Belongs to the TMEM141 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: KAPC_YEAST
Sequence: MYVDPMNNNEIRKLSITAKTETTPDNVGQDIPVNAHSVHEECSSNTPVEINGRNSGKLKEEASAGICLVKKPMLQYRDTSGKYSLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVIWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEEEFNYGIQGEDPYMDLMKEF
What are the official names of this protein?
cAMP-dependent protein kinase type 3, PKA 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Protein: SR543_HORVU
Sequence: MVLADVGGSISRALAMSSAAVVDESVLRECLNEIARALMQSDVRFKTVCDLQANIRKTVNLEALAAGTNKRRIIETSVGKELCKMLDTGKPAFVPKKGKPNVVMFVGLQGSGKTTTCTKYAHYHQRKGFKPSLVCADTFRAGAFDQLKQNATKAKIPFYGSYMESDPVKIAVEGLEKFRQEKSDLIIIDTSGRHMQEAALFEEMRQVAEATKPDLVIFVMDGSIGQAAFDQAQAFKQSASVGAVIVTKLDGHAKGGGALSAVAATKSPVIFIGTGEHIDDFDVFNVEPFVARLLGRGDLPGLIDKMESIVPADQQSELVAKLSEGAFTLRLLYEQFQNLLKMGPMSQIFSMLPGFSSELMPKGQEKQSKEKFKRYMTIMDSMTPAELDSTNPKLMTESRIIRVARGSGRKVKDVMEMLEEYKRLAKMWSKRNVSKLIPQNGKMSAQAIQKMLKVMPPQVVQQMGGKSGLEALLKQLGGGKDTSKMLAGMRGGA
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).  As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane.  Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.  Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA.  Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA.  SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity).  Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity).
What are the official names of this protein?
Signal recognition particle subunit SRP54 3, Signal recognition particle 54 kDa protein 3, SRP54.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3_BORGP
Sequence: MINRNANRDRDRSRSNDKELKINYRIKAREVRVIFENGIQEVLSIEDAIKKAKEAGLDLVEVSPNVSPPVCKIIDYGKYKFHQEKRQKEQKKNQKVIKLKEVRMQPKIDTHDLDFKSKNILSFLKDGNKVKVTIRFRGRELAHTYLGYDILNSILEKVGEVNYVLESAAKMEGKTMFLIVAPKFKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_ECOLI
Sequence: MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.  The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA.  In addition, small hydrophobic peptides are also hydrolyzed by HslV.  HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU.  HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis.  HslV is not believed to degrade folded proteins.
What are the official names of this protein?
ATP-dependent protease subunit HslV, Heat shock protein HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.