PharMolix/UniProtQA huggingface dataset:
Protein: RLME_ECO24
Sequence: MTGKKRSASSSRWLQEHFSDKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYVVTQIGGKGRIIACDLLPMDPIVGVDFLQGDFRDELVMKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALEMCRDVLAPGGSFVVKVFQGEGFDEYLREIRSLFTKVKVRKPDSSRARSREVYIVATGRKP
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFNG_VULVU
Sequence: MNYTSYILAFQLCVILCSSGCNCQAMFFKEIENLKEYFNASNPDVSDGGSLFVDILKKWREESDKTIIQSQIVSFYLKLFDNFKDNQIIQRSMDTIKEDMLGKFLNSSTSKREDFLKLIQIPVNDLQVQRKAINELIKVMNDLSPRSNLRKRKRSQNLFRGRRASK
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: PCDBF_PANTR
Sequence: MEPAGERFPEQRQVLILLLLLEVTLAGWEPRRYSVMEETERGSFVANLANDLGLGVGELAERGARVVSEDNEQGLQLDLQTGQLILNEKLDREKLCGPTEPCIMHFQVLLKKPLEVIRAELLVTDINDHSPEFPEREITLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHVSTRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAPEFAQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSEEINKPFELSSLSGEIRLIKKLDFETMSSYDLDIEASDGGGLSGKCSVSVKVLDVNDNFPELSISSLTSPIPENSPETEVALFRIRDRDSGENGKMICSIQDDVPFKLKPSVENFYRLVTEGALDRETRAEYNITITITDLGTPRLKTQHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPHLPLASLVSINTDNGHLFALRSLDYEALQAFEFHVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYVVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRYSVPEGPFPGHRVDVSGTGTLSQSYQYEVCLTGGSESNDFKFLKPIFPNIVSQDSRRKSEFLE
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin beta-15, PCDH-beta-15.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RNPH_ACTPJ
Sequence: MRPNNRELNQVRPVKITRHYTRYAEGSVLVEFGETKVLCNATVEETVPRFLKGQQQGWVTAEYGMLPRSTHSRMQREAAKGKQGGRTMEIQRLIARSLRAVVDLKALGERTVTVDCDVIQADGGTRTAAITGACVALHDAMSKLVADGVLKENPMKGLVAAISVGIVDGNAVCDLEYVEDSNAETDMNVVMVEDGRLVEVQGTAEGEPFSHMELLQLLDLAHQGINQLLDAQRKALAL
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: RPOA_LIRTU
Sequence: MVREEVAVSTRTLQWKCVESRTDSKRLYYGRFILAPLMKGQADTIGIAMRRALLGEIEGTCITRVKSEKVPNEYYTIVGIEESVHEILMNLKEIVLRSHLYGTRDASICVRGPRYVTAQDIIPPPSVEIVDTTQHIASLTEPIDLCIELQIERDRGYRMKTPNNYQDGSYPIDAVSMPVRNANHSIHSYGNRNEKQEILFLEIWTNGSLTPKEALHEASRNLIDLFIPFLHAEEQDIVLEDNPNRFTVPLFTFHDRLANIRKNKKGIALKCIFIDQSELPPRTYNCLKRSNIHTLLDLLSNSQEDLMRIEHFRIEDVKQILDILQKHFTIDLPKNKF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EBFC_BORRA
Sequence: MAVNPLDFLKNMSNFKDNIDNIKKEISQIVVCGRAGSDVVVVEMNGEFVVKKILIKEDFFNDLDNEALEHMIKSAFNDAVFKVKEEIKSKTMGSIPFGI
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein EbfC.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: BMTID_RHIMP
Sequence: AVDFSKVPTATAGPCKG
What is the function of this protein?
Inhibits bovine trypsin and human plasma kallikrein, but not human neutrophil elastase.
What are the official names of this protein?
Kunitz-type serine protease inhibitor D, BmTI-D.
What are the subcellular locations of this protein?
Secreted.
Protein: Y3247_VIBC1
Sequence: MKLWVDADACPKVIRETIVRAAERTGVECTFVANHVVPVPKRANIHSLQVPAGFDIADNEIVRRVEANDLVITSDIPLADEVISKGAQALSSRGELYTKDTIKARLNIRDFMDTMRSSGIQTGGPAALSQTERREFANHLDRILAKR
What are the official names of this protein?
UPF0178 protein VIBHAR_03247.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: FABH_LISMF
Sequence: MNAGILGVGKYVPEKIVTNFDLEKIMDTSDEWIRTRTGIEERRIARDDEYTHDLAYEAAKVAIKNAGLTPDDIDLFIVATVTQEATFPSVANIIQDRLGAKNAAGMDVEAACAGFTFGVVTAAQFIKTGAYKNIVVVGADKLSKITNWDDRTTAVLFGDGAGAVVMGPVSDDHGLLSFDLGSDGSGGKYLNLDENKKIYMNGREVFRFAVRQMGEASLRVLERAGLEKEDLDLLIPHQANIRIMEASRERLNLPEEKLMKTVHKYGNTSSSSIALALVDAVEEGRIKDNDNVLLVGFGGGLTWGALIIRWGK
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_DROPE
Sequence: MVTTTPENEVLTSTSAVTGLPQKRYYRQRAHSNPIADHCFDYPARPEDVDWRSLYPSIRADQEVSFADIGCGYGGFLVTLGELFPEKISIGMEIRVKVSDYVLDRITALRQKSSGTGAYQNIACLRTNAMKYLPNYFRKGQLEKMFFLYPDPHFKRAKHKWRIINQALLSEYAYVLRKGGLVYTMTDVEDLHNWIVTHMDEHPLYERLDEEEANTDPITPKLYQSSEEGAKVVRNKGDHFLAIFRRL
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL7_AQUPY
Sequence: MATLTIDEIVEAIKNMSVLEVAELVKRLEEEFGVSAAAMVAAAPAAGAAAGAPAQAEEKTEFDVILKSPGKNKIQVIKVVREITGLGLKEAKELVDNAPKPIKEGVPKEEAEQIKKKLEEAGAEVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PT317_ARATH
Sequence: MAKMINKTLVLTYIYLLIYIILSSGVILYNKWVLSPKYFNFPLPITLTMIHMGFAGFVAFLLIRVFKVVAPVKMTFEIYATCVVPISAFFASSLWFGNTAYLHISVAFIQMLKALMPVATFIMAVVCGTDKPRCDVFSNMLLVSVGVVISSYGEIHFNIVGTVYQVTGIFAEALRLVLTQVLLQKKGLTLNPITSLYYIAPCSFVFLALPWYVLEKPTMEVSQIQFNFWIFFSNALCALALNFSIFLVIGRTGAVTIRVAGVLKDWILIALSTVIFPESTITGLNITGYAIALCGVVMYNYIKVRDVKASQPTADSLPDRINKEYKMEKKSSDKFNPNDSVEIPRVGGEVNDEEAPLITSRLSHIGRTQLGNHAA
What are the official names of this protein?
Probable sugar phosphate/phosphate translocator At3g17430.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. TPT (TC 2.A.7.9) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LPQE_MYCBO
Sequence: MNRCNIRLRLAGMTTWVASIALLAAALSGCGAGQISQTANQKPAVNGNRLTINNVLLRDIRIQAVQTSDFIQPGKAVDLVLVAVNQSPDVSDRLVGITSDIGSVTVAGDARLPASGMLFVGTPDGQIVAPGPLPSNQAAKATVNLTKPIANGLTYNFTFKFEKAGQGSVMVPISAGLATPHE
What are the official names of this protein?
Putative lipoprotein LpqE.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: Y1770_MYCTU
Sequence: MARTDDDNWDLTSSVGVTATIVAVGRALATKDPRGLINDPFAEPLVRAVGLDLFTKMMDGELDMSTIADVSPAVAQAMVYGNAVRTKYFDDYLLNATAGGIRQVAILASGLDSRAYRLPWPTRTVVYEIDQPKVMEFKTTTLADLGAEPSAIRRAVPIDLRADWPTALQAAGFDSAAPTAWLAEGLLIYLKPQTQDRLFDNITALSAPGSMVATEFVTGIADFSAERARTISNPFRCHGVDVDLASLVYTGPRNHVLDYLAAKGWQPEGVSLAELFRRSGLDVRAADDDTIFISGCLTDHSSISPPTAAGWR
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Rv1729c.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: GPI7_YARLI
Sequence: MLWKRWTLAVTIVVLQLAAVLLFARGFLPSRVLLPGYTESRVSTEAPFQKAIIMVVDAFRSDFAFSDQSNCPQLHKRINSGGAIPFTAHSTPPTVTLPRIKGLTTGSTPNFLDAVLNIAESDNSSTLANQDSWLAQASRDGRKIHMFGDDTWIKLFPGMFDDCEGTASFFVSDYTEVDNNVTRHIDTQLDQKTEWDVLILHYLGLDHIGHKTGPESPFMPAKQKEMDDIFDKLYNSCDDDTVLILLGDHGMNEVGNHGGSSAGETSAAMVFASPKFETAQLTETAETSPLPWTDTYKYHSRMDQTDLVPTLTALLGLNTPKNNLGVLVSQMLGLWSPEDQLNVLKNNADQMVQILQGQASRESDAKEVYELYDTLNSNPSVKDYYNFLYEAQSYLTHASSNYNTNDMLGGIGLGLLSTILALTVFSALTLAVQGLKRLYLIILLVYFISVFGSSTVEEEHQIWYWITSGWMAFLYISGSRNKFGDGFNWMFVQVFVRMMISWNQTGQKFTKKDDIVTWLSKDGNHPVLWILILVTYGVAFNKVWRYGFSKVESKLAFLLTLITTFASVGFKITQAWEAGEVVPAPLLYLMGLPGTLNEVNARMAGLARFAFSTIAAGSLYRVLSLAGTDKVNLIRDLHAFLTLFLITQSRIQNIPLFMVYYFLEIFLRKATNRSFIFSSRDIYQTEALFQKLVLVLSVSTLLLEQVSFFSMGNSNSMASIDLSNAYNGVTLYQIEFVGVLTFVSNWIGPLYWSTAGLSFLLEDHVRNAIFAKIAEKNNDVKLTTKLVQQALTLRVYVVLAFSSVAISAVMITCFFLREHLFIWTVFSPKLLYQFVWTVLQFALVDVILSSIFVVLVYRSV
What is the function of this protein?
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers ethanolamine phosphate to the GPI second mannose (By similarity).
What are the official names of this protein?
GPI ethanolamine phosphate transferase 2, Glycosylphosphatidylinositol-anchor biosynthesis protein 7.
What is the protein family that this protein belongs to?
Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PSBF_PHYAM
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: Y098_MYCSK
Sequence: MRRQEAGTSSLATRVGPEVLTTAAVASVTGCDDPLAAVLLGRPKVIEVLQRSAELIDRVPALAAAHHQIADYHAMRSRFFDAYLADAAAEGIRQCVVLAAGLDTRAFRLPWPDGMTVFEIDQPTVLRYKENALTAHGARPAADWHPVGVESDMPWPRRLWESGFNHNEPTIWLAEGLLPLPDATQDALISEIDGLSAAGSRIAFDDVLGMCSGRSDAPGWLTSRGWWTDVVEARHLPELSGRRDDDAQSYTAHAALVTAEKIA
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase Mkms_0098.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: RL38_DROME
Sequence: MPREIKEVKDFLNKARRSDARAVKIKKNPTNTKFKIRCSRFLYTLVVQDKEKADKIKQSLPPGLQVKEVK
What are the official names of this protein?
60S ribosomal protein L38.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL38 family.
Protein: RSRP1_MACFA
Sequence: MSNYVNDMWPGSPQEKDSPSASRSGGSSRLSSRSRSRSFSRSSRSRSRVSSRFSSRSRSRSRRSRSRSRSRRRHQRKYRRYSRSYSRSRSRSRSRRYRERRYGFSRRYYRSPSRSRSRSRSRSRSRSRERSYYGRAYAMARGRRYYGFGRTVYPEERSRWRDRSRTRSRSRTPFRLSEKDRMELLEIAKANAAKALGTTNIDLPASLRTVHVAKETSHGIGVSSNGAKPELSENVTEDGPRNPSEKPSQQRSIAFSSNNSVAKPIQKSAKAATEETSSRSPKIDKKKSPYGLWIPV
What is the function of this protein?
Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.
What are the official names of this protein?
Arginine/serine-rich protein 1.
What is the protein family that this protein belongs to?
Belongs to the RSRP family.
Protein: TYSY_BACLI
Sequence: MSHYDQQYNAIIQKIIESGISDEEYQVRTKWDSDGTPAHTLSIMSEKMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVQVLNDMGVHIWDQWRLEDGTIGAAYGYQLGKKNRTVNGQKVDQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQWYVKEGKLSLEVRARSNDMALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYEAPKLWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDIA3_RAT
Sequence: MRFSCLALLPGVALLLASALLASASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEDEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNVESLVKEYDDNGEGITIFRPLHLANKFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIPETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL
What is the function of this protein?
Disulfide isomerase which catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds (By similarity).  Associates with calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity).  Association with calcitriol does not affect its enzymatic activity (By similarity).
What are the official names of this protein?
Protein disulfide-isomerase A3, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, p58, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 57, ER protein 57, ERp57, Endoplasmic reticulum resident protein 60, ER protein 60, ERp60, HIP-70, Q-2.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome.
Protein: CAN7_HUMAN
Sequence: MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEYLERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLCLKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLGANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMPFCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDNSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPWSHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNPGLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFANNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYEKQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFHIEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSGIFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ
What is the function of this protein?
Calcium-regulated non-lysosomal thiol-protease.
What are the official names of this protein?
Calpain-7, PalB homolog, PalBH.
What is the protein family that this protein belongs to?
Belongs to the peptidase C2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPTC4_HUMAN
Sequence: MNVTPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEFTNHWWNELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETVLGGGTREAESRACSDGRSRKSKKKRQQHQEEEDILDVRDEKDGGAREAESRAHTGSSSRGKRKRQQHPKKERAGVSTVQKAKKKQKKRD
What are the official names of this protein?
G patch domain-containing protein 4.
Protein: PUR7_LACPL
Sequence: MTAAIEKQALLYTGKAKAMYATNDPEILWVEYLDQATALNGKRKVPIDQKGRLNNRIASLIFKDLANHGIANHFIEQPSDYVQLVRRVTMIPLETVVRNAASGSFERKFAVPHLTKFAEPVLEFFYKSDQLDDPFINDSQIHALNVATPAIVAEIKRQALQVNQRLTAIFAAMGVQLVDFKIEFGLTTTGKVLLADEISPDSCRLVDLKTGASLDKDVFRKDLGDLTSVYQEVLTRLATVEEA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: DNAJ_METRJ
Sequence: MSKRDYYEILGVTKTATEGEMKVAFRKLAMTYHPDRNPGDKDAEIKFKEINEAYQCLSDGQKRAAYDRFGHAAFSQGGGGPGFGNEFGDFMSDIFDNFFGDGRGGGGARGRGGTPGRERGADLRYNLEITLEEAFTGKAETIKIPTSITCEVCDGSGAKPGSKPRTCPTCAGYGRVRAAQGFFAIERTCPNCHGRGEIVDDPCTACQGAGRVNRERTLSINVPAGVDDGLRIRLAGEGESGLRGGPAGDLYVFLSIKQHEFFQRDGADLFCRVPISMVTAALSGEITVPVIDGSQTQVRIPAGTQTAKQFRIKGKGMPVLRSREVGDLYIQVFVETPQNLTKRQRELLQEFDLSASPENHPESAGFFSKVRDFFGGAVRP
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2C38_ARATH
Sequence: MVSSATILRMVAPCWRRPSVKGDHSTRDANGRCDGLLWYKDSGNHVAGEFSMSVIQANNLLEDHSKLESGPVSMFDSGPQATFVGVYDGHGGPEAARFVNKHLFDNIRKFTSENHGMSANVITKAFLATEEDFLSLVRRQWQIKPQIASVGACCLVGIICSGLLYIANAGDSRVVLGRLEKAFKIVKAVQLSSEHNASLESVREELRSLHPNDPQIVVLKHKVWRVKGIIQVSRSIGDAYLKKAEFNREPLLAKFRVPEVFHKPILRAEPAITVHKIHPEDQFLIFASDGLWEHLSNQEAVDIVNTCPRNGIARKLIKTALREAAKKREMRYSDLKKIDRGVRRHFHDDITVIVVFLDSHLVSRSTSRRPLLSISGGGDLAGPST
What is the function of this protein?
May dephosphorylate and repress plasma membrane H(+)-ATPases (PM H(+)-ATPases, e. g.  AHA1 and AHA2), thus influencing negatively plant growth and fitness (By similarity).  Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling (PubMed:27494702).  Negatively regulates immune responses by controlling the phosphorylation and activation status of BIK1, a central rate-limiting kinase in PTI signaling (PubMed:27494702).  Impairs the phosphorylation of the NADPH oxidase RBOHD by BIK1 (PubMed:27494702).
What are the official names of this protein?
Probable protein phosphatase 2C 38, AtPP2C38.
What is the protein family that this protein belongs to?
Belongs to the PP2C family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GLH3_CAEEL
Sequence: MDKSPTKTSIRTKFARHQPISDVDTTEQSSSCIKKDDRGLSSFGVQSSVFSRRSCRMSELEAKPTIISEDQRIAVRSEIGGSFSGFDDKVDNVFHSNNNLHGSPSTTELECPGIMNPRFLVGRSLNSRSRAVTRGSKRTSNVKENEGSIHRSDDQVSTENCSAKDEERDRDSGGVSSYGNKRSDEFCGTSPILEAKGFGISNTCFNCKKYGHRATECSAPQRECANCGDPNHRANECASWSKNGVQEPTKVTYVPVVDKMEEVFSMLKINAGDFFDKFFDASVQLVSRGQPVTIQPCKSFSDSDIPQSMRRNVERAGYTRTTPIQQYTLPLVADGKDILACAQTGSGKTAAFLLPIMSRLILEKDLNYGAEGGCYPRCIILTPTRELADQIYNEGRKFSYQSVMEIKPVYGGINVGYNKSQIMKGCTIIVGTIGRVKHFCEDGAIKLDKCRYLVLDEADRMIDSMGFGPEIEQIINYKNMPKNDKRQTMMFSATFPSSVQEAARKLLREDYTMITIDKIGAANKCVIQEFELCDRTSKVDKLLKLLGIDIDTYTTEKNSDVFVKKTIVFVAQQKMADTLASIMSAAQVPAITIHGAREQKERSAALKLFRSGAKPVLIATAVVERGLDIKGVDHVINYDMPNNIDDYIHRIGRTGRVGNSGRATSFISLADDVQILPQLVRTLADAEQVVPSWMKEAAGGTSNPNKFEKSIDTEEPEEAW
What is the function of this protein?
Probable ATP-binding RNA helicase.
What are the official names of this protein?
ATP-dependent RNA helicase glh-3, Germline helicase 3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.