PharMolix/UniProtQA huggingface dataset:
Protein: CBIM_DESRM
Sequence: MKYWGTALLGAFCVFFFTPNTAYAMHIAEGFLPAGWCLFWLALSVPFVFWGIRSIHISLRGNPHLKMLLGLAGAFVFVLSALKIPSVTGSCSHPTGVGLGAILFGPAVMSVLGCIVLLFQALLLAHGGITTLGANVFSMGVMGPLVSYGVYQLLKKRNTKVAVFLAASLGNMTTYMVTSLQLAMAFPDKTGNLLVSFFKFMSIFAITQIPLAITEGLLTVFVFNLLNNYREELYPGLPKEERSGPYDFVN
What is the function of this protein?
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
What are the official names of this protein?
Cobalt transport protein CbiM, Energy-coupling factor transporter probable substrate-capture protein CbiM, ECF transporter S component CbiM.
What is the protein family that this protein belongs to?
Belongs to the CbiM family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SHC2_MOUSE
Sequence: MTQGPGGRAAPEPEAPTTFCALLPRMPQWKFAAPGSFLGRGPAATRVAGVAEAQPEPGVPALAAVLGACEPRCAAPCPLPALGRCRGSGTRGARVTPDVADEWVRKGGFIHKPAHGWLHPDARVLGPGVSYIVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASILGKSNLRFAGMSISVNISVDGLNLSVPATRQIIANHHMQSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSVISTVGQAFELRFKQYLHSPPKAVVPPERLTGLEELAWGDDDAAADHNYYNSIPGKEPPLGGLVDSRLAVTQPCALATLGGLGQGMTPVWRDARGLPWDMGPSGAAPPGDGYVQADARGPHDYEEHLYVNTQGLDAVELEDTAEAPLQFEDSPKKDLFDMRPFEDALKLHACSVAAGITAASPPLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGRMSRRAAEKLLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDYHLKNGLPIVAAESELHLRGVVSREP
What is the function of this protein?
Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons.  Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
What are the official names of this protein?
SHC-transforming protein 2, Protein Sck, Protein Sli, SHC-transforming protein B, Src homology 2 domain-containing-transforming protein C2, SH2 domain protein C2.
Protein: RS16A_YEAST
Sequence: MSAVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPLLLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSKNELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
40S ribosomal protein S16-A, RP61R, Small ribosomal subunit protein uS9-A.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX15_BOVIN
Sequence: MQRLLFTPLTAFLGSPCLRLLVPRVAPRTQCGCSCGIRRPLRPGQYSTISDVALQPGRSTVSLPSKAAERVVGRWLLVCSGTVAGAVILGGVTRLTESGLSMVDWHLIKEMKPPTSKEEWEAEFQKYQQFPEFKILNHDMTLAEFKFIWYMEYSHRMWGRLVGLAYILPAAYFWKKGWLTRGLKGRVLALCGLVCFQGLLGWYMVKSGLEEKPDSHDIPRVSQYRLAAHLGSALVLYCASLWTSLSLLLPQHKLTETRQLLRLRRFAHGTAGLVFLTALSGAFVAGLDAGLVYNSFPKMGESWIPEDLFTFSPLLRNVFENPTMVQFDHRVLGIASVTAVTVLYFLSRRIPLPRRTKIAATTLLALAYTQVGLGISTLLMYVPTPLAATHQSGSLALLSVALWLMNELRRVPK
What is the function of this protein?
May be involved in the biosynthesis of heme A.
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX15 homolog.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: LGT_CAMJD
Sequence: MEFWQHIYSNFNVIAFSIFGLKVHWYGIMYDVALLLALLLAKFFVRKFQLDINEKHLYSYFIWVEIGVILGARLGYILIYDANTMYYITHPWQIFNPYINGEFVGIRGMSYHGAIIGFLIATLLFCKKYKTNPWIFLDLVALSVPLAYVFGRIGNFLNQELFGRITNVPWGIYIDGVLRHPSQFYEAFLEGIVVFIIVYLARFKQSFQGELILVYAGAYSLARFICEFYREPDFGIGFVLWGMSMGQILSFIMFITALLVYICIKFKKVNI
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y1517_PSEFS
Sequence: MKRICSIYRSKKKDGMYLYVLKSDALERVPEPLMEAFGKAHHAFDMVLTPERKLSREDIAVVLENLDKQGYHLQMPPAEDEYIEHLPEELLRRNDPM
What are the official names of this protein?
YcgL domain-containing protein PFLU_1517.
Protein: WDR26_XENTR
Sequence: MQANGAAAAAAGEEPAGSGCLSAHNGESSEPAHSNGVLSSNNGLSGTGSTGPTEQPGGRKKKRLSQADEDVIRLIGQHLHGLGLNQTVDLLMQESGCRLEHPSATKFRNHVMEGEWDKAENDLNELKSLVHSPHAVAACRPSSGGSGSEHSPTSCPTADVIRRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCSHADDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHNTKLDNNLDSVSLLIDHVCSRKQFPCFTQQVLTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHQLKLLKTLEGHAYGVSYLAWSPDDNYLIACGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISRNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYVWHKRSELPIAELTGHTRTVNCVSWNPQIPSLMASASDDGTVRIWGPAPYVDNQEFEEECSSMNS
What is the function of this protein?
G-beta-like protein involved in cell signal transduction.  Acts as a negative regulator in MAPK signaling pathway.  Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes.  Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).  Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation.  Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration.  Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity).  Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
What are the official names of this protein?
WD repeat-containing protein 26.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion.
Protein: NV7_NEMVE
Sequence: MASFFKIAVICLVMLVVCSNARVIDVDDDYLMDFAASKRGGQTCYCRGGSGPTGGFWGGQNCPAGMTSCRKNILGNCCQKSKEGTDCDI
What is the function of this protein?
Probable toxin.
What are the official names of this protein?
N.vectensis toxin 7, Nv7.
Protein: NADE_LIMRJ
Sequence: MRKYQEEIINALGVNSQIDPQAEVTKRVQFICDFLQTTKMKALVLGISGGQDSSLAGRLSQLAVEKLREETGDNEYQFIAVRLPYGEQADESDAMFAINDFIKPDKIMRVNIKAATDAMVASLNEAGTPISDFSKGNIKARERMIVQYAIGGENKGAVVGTDHAAEAVTGFYTKFGDGGADITPLSGLDKRQGKALLQYLGAPAKLYDKTPTADLEEDKPMRPDEEALGVRYDEIDDYLEGREVSPAAAEKIESWYRRTQHKRHLPIAPYDTWWK
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: SYA_BRADU
Sequence: MSGVNEIRSTFLNFFAENGHEIVPSSPLVPRNDPTLMFTNAGMVQFKNVFTGVEKRPYQRATTSQKCVRAGGKHNDLDNVGYTARHLTFFEMLGNFSFGDYFKERAIELAWKLITKDFGLNKDKLLVTVYHTDDEAHGLWKKIAGFSDDRIIRIPTSDNFWAMGDTGPCGPCSEIFIDRGDHIWGGPPGSPEEDGDRFLEFWNLVFMQYEQVTKEERVDLPRPSIDTGMGLERMACIMQGVDSVFETDLFRHLIDATASALGSGPNEQTVASFRVIADHLRSSAFLVSDGVLPSNEGRGYVLRRIMRRAMRHAQLLGAKEPLMHRLVWALVREMGQAYPELMRAEKLIEETLRLEETRFRKTLTRGLAILDEKSASLKKGDMFDGDVAFTLYDTYGFPLDLTQDALKSRGIGVDQSAFTDAMERQKAKARESWKGSGEAASEAIWFPLREKLGATEFLGYETESAEGVVSALVKDGQEAASLKAGETGALVLNQTPFYAESGGQVGDTGVLLGEGGVKFRVTDTQKKLGDLFVHVGTVESGELKLGTALQLEVDHSRRSSIRAHHSATHLIHEALRQVLGDHIAQRGSMVAPDRLRFDFVHPKPITAEELARVEDIANDVVLENDEVTTRVMGVDEAREAGARALFGEKYGDEVRVVSMGRTARERGANALGWSVELCGGTHVRRTGDIGLITLTGESAVASGVRRIEALTGNYARKHANDTMALAKTAANELRTSIDDVPARITALMEERKKLERELSDARKKLAMGGGAAASNGAASGVREVGDVKLMARAVEGIEMKDLKSLADDGKKQIGSGVVAIVGVTGDGKAGIVVGVTADLTARFNAVNLVRVASEALGGKGGGGRPDMAQAGGPDGAKAPEALAAIEKAMAGA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAY_YERPY
Sequence: MNDSEFHQLADQLMLYIEETLDGFTGDSDIDYETNGGVMTLTFENGSKIVINRQEPLHQVWLATKAGGYHFNYRDGHWYCSRSGEEFLAKLSEAASAQAGENVSFG
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: AAEB_CITK8
Sequence: MGIFSIANQHIRFAVKLACAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIIGTFIGCIAALTIIITMIRAPLLMILVCCIWAGFCTWISSLVRVENSYAWGLSGYTALIIVITIQAEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSVKQEVDREVDGLLVAQYQLMQLCIKHGDSEEVDKAWGDLVRRTAALEGMRSNLNMESSRWGRANRRLKALNTLSLTLITQSCETYLIQNTHPELITDTFRELFETPVETAQDVHKQLKRMRRIIAWTGERETPVTLYTWAGAATRYLLLKRGVIGNAKISVTEEEVLQGEPVVKVESAERHHAMVNFWRTTLSCVLGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCLSLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCMMAFIVILLVRDNSRDRTGRVLLNQFVSAAVSAMTTNVVRRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNHDLSAFHRQLRRTADHVISAGNDDKRRRYFGQLLDELDVYQEKLRVWEAPPRVTEPVKRLSGMLHKYQHALTDN
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SC11A_MOUSE
Sequence: MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITGSESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKQDGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFKYAVLFLLGLFVLVHRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11A, Endopeptidase SP18, Microsomal signal peptidase 18 kDa subunit, SPase 18 kDa subunit, SEC11 homolog A, SEC11-like protein 1, SPC18, Sid 2895.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: DNCV1_ECOLX
Sequence: MPWDFNNYYSHNMDGLISKLKLSKTESDKLKALRQIVRERTRDVFQEARQVAIDVRRQALTLESVRLKLEKTNVRYLSPEERADLARLIFEMEDEARDDFIKFQPRFWTQGSFQYDTLNRPFHPGQEMDIDDGTYMPMTVFESEPSIGHTLLLLLVDTSLKSLEAENDGWVFEEKNTCGRIKIYREKTHIDVPMYAIPKEQFQKKQTAADSAHLIKSDSVFESFALNRGGREAYAVESDKVNLALREGVRRWSVSDPKIVEDWFNESCKRIGGHLRSVCRFMKAWRDAQWEVGGPSSISLMTAVVNILDRESHNGSDLTGTMKLIARLLPEEFNRGVESPDDTDEKPLFPAESNHNVHHRAIVETMEGLYGILLAAEQSESREEALRKINEAFGKRVTNALLITSSAAAPAFLNAPSKEPSSKPINKTMVSG
What is the function of this protein?
Catalyzes the synthesis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP) from GTP and ATP, a second messenger in cell signal transduction.  Is also able to produce c-di-AMP and c-di-GMP from ATP and GTP, respectively; however, 3'3'-cGAMP is the dominant molecule produced by DncV in vivo, contrary to the 2'3'-cGAMP produced by eukaryotes.  By producing cGAMP, down-regulates csgD expression and expression of flagellum regulon genes, which leads to the down-regulation of rdar biofilm formation and flagellum-mediated swimming and swarming motility in a temperature-dependent manner (PubMed:30837338).  Controls the activity of cGAMP-activated phospholipase CapV, a patatin-like lipase that is a direct 3',3'-cGAMP receptor encoded in the dncV operon (By similarity).
What are the official names of this protein?
Cyclic GMP-AMP synthase, c-GAMP synthase, c-GMP-AMP synthase, 3'3'-cGAMP synthase, CD-NTase001.
What is the protein family that this protein belongs to?
Belongs to the CD-NTase family. A01 subfamily.
Protein: ACTM_MOLOC
Sequence: MSSEEEDQTAIVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRIAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGISHNVPIYEGYALPHAIARMDLAGRDLTEYLTKILTERGYSFVTTAEKEIVRDIKEKLCYVALDFEQEMATAASSTSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILSSLSTFNQMWITKAEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.  Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
What are the official names of this protein?
Actin, larval muscle-type, A1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: KEX1_PHYIT
Sequence: MVTRHVLAAALAGSMTSAQRLHPTSQRASDDLIQNLPGLDPAAKVTQHAGRIALHDNDKNKMFYWHFQAAQDPEKAPLVIWLNGGPGCTSMQGLFLGNSPFTLKDDSTIGKNEHSWHEFANLLFVDQPIGTGMSYTKGNDYRLDEETIAQDFYEFLTKFLQRHNKYLSDGDDGVSNSRAVYMFGESHAGRWIPEFSDHIMKQNNDPKNQIKINLDGVGIGNGWVHPRIQYEYSDYAHGLGLLTFGQVRSLKASYAECLAALDAGTYYSRSCLDNMDSITGSVKPGNGGNSLNFYDVRQYLRNVGSYPSGQSNIAKYMNKMEVRKAVHGNEDKNFRFDLCSNGVFRALSKFDGVSTLDKVESLLQQGLRMIFYNGQWDMMCNHYGTEKLLLNLNWNGSDAYQQADKYTWRVQGRKEPAGFAQQGGNLTYLVVTGAGHMVPMDVPDVAADILRRFVNRLEFNDKVQTVVTTRLNATDMEVSFCYSPSVSADPDTSLSTRDQTGANSSQVHIGIAWLWVALVIAVVSSVLAVCVTIVCIRNKRNGKQEHEMITQVSDDEEVNQIEDESEEGFSDEDVGVHVLVSNVSQRATSPRSRVTEV
What is the function of this protein?
Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors.  Promotes cell fusion and is involved in the programmed cell death (By similarity).
What are the official names of this protein?
Pheromone-processing carboxypeptidase KEX1, Carboxypeptidase D.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
Protein: Y381_TREPA
Sequence: MLGAELADTGLFVRFGALHFAIASVAVLLSALFVLLPFALPRLLAHKNLARAGVAILFLRLGLMLCGTLLDGRSWRNELPFHLCPAALISGSLYFITRRPIFFNLLYFWHFGSFVAVLYPDLTRAHTILYAYLFMLTHCLEPAMVVFSLLHLRERISKRGLQCAVLGFLLLAANALFWNRRLGANYLFISKYPLEILRVIRPFFVYQLLFVSALCLLMLVLYLPFRPSQHGRNQLFVI
What are the official names of this protein?
Uncharacterized protein TP_0381.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MOT2_HUMAN
Sequence: MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI
What is the function of this protein?
Proton-coupled monocarboxylate symporter.  Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:9786900, PubMed:32415067).  Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067).
What are the official names of this protein?
Monocarboxylate transporter 2, MCT 2, Solute carrier family 16 member 7.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UFM1_ARTSF
Sequence: MGSKVTFKITLTSDPKLPFKVLSVPEATPLTAVLKFAAEEFRVPAATSAIITDDGAGINPQQTAGNVFLKHGSELRLIPRDRVGFTTTYHSSLNVCLF
What is the function of this protein?
Ubiquitin-like modifier protein which binds to a number of as yet unidentified target proteins.
What are the official names of this protein?
Ubiquitin-fold modifier 1.
What is the protein family that this protein belongs to?
Belongs to the UFM1 family.
Protein: ATPL_WOLPM
Sequence: MDLVALKFIAIGLAVFGMLGAGLGIANIFSAMLNGIARNPESEGKMKSYVYIGAAMVEIMGLLAFVLAMLLIFAA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL4_SALAR
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: NUOB_COXB2
Sequence: MQQLLTKEGFLLTSLDDLMRWARSGSLWPMTFGLACCAVEMMQCASSRYDLDRFGAGLFRPSPRQSDVMIVAGTLCNKMAPALRKVYDQMAEPRWVISMGSCANGGGYYHYAYSVVRGCDRIVPVDVYVPGCPPTAEALFYGIMQLRNKIRYRNIFDRKDA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FOLD_STRSV
Sequence: MAQIIDGRGLAEKLQKKLAEKTARLKEKTGQVPGLVVIVVGNNPASQIYVRNKERSALAAGFRSKVERLPEETSQEELLSLIETYNQNPDWHGILVQLPLPEHIDDEAVLLAIDPDKDVDGFHPLNMGKLWSGHPVMIPATPAGIMAMFHEYGIELEGKRAVVIGRSNIVGKPMAQLLLAKNATVTLTHSRTHNLAKTAKRADILVVAIGRGHFVTKNFVKEGAVVIDVGMNRDENGKLIGDVKFDEVAEIASLITPVPGGVGPMTITMLMEQTYQAFKRSLES
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: PAMR1_MOUSE
Sequence: MELDRWAQLGLVFLQLLLISSLPREYTVINEACPGAEWNIMCRECCEYDQIECLCPGKKEVVGYTIPCCRNEDNECDSCLIHPGCTIFENCKSCRNGSWGGTLDDFYVKGFYCAECRAGWYGGDCMRCGQVLRASKGQILLESYPLNAHCEWTIHARPGFIIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNERPAPIRSTGSSLHVLFHSDGSKNFDGFHAVFEEITACSSSPCFHDGTCLLDTTGSFKCACLAGYTGQRCENLLEERNCSDLGGPVNGYKKITEGPGLLNERHVKIGTVVSFFCNGSYVLSGNEKRTCQQNGEWSGKQPVCMKACREPKISDLVRRRVLSMQVQSRETPLHQLYSTAFSKQKLQDASTKKPALPFGDLPPGYQHLHTQVQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKIESTPSPKTQGTRWPWQAAIYRRTSGVHDGGLHKGAWFLVCSGALVNERTVVVAAHCVTELGKATIIKTADLKVVLGKFYRDDDRDEKSIQNLRVSAIILHPNYDPILLDTDIAVLKLLDKARISTRVQPICLATTRDLSTSFQESHITVAGWNILADVRSPGFKNDTLHYGMVRVVDPMLCEEQHEDHGIPVSVTDNMFCASKDPSTPSDICTAETGGIAALSFPGRASPEPRWHLVGLVSWSYDKTCSNGLSTAFTKVLPFKDWIERNMK
What is the function of this protein?
May play a role in regeneration of skeletal muscle.
What are the official names of this protein?
Inactive serine protease PAMR1, Peptidase domain-containing protein associated with muscle regeneration 1, Regeneration-associated muscle protease homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYI_AGRFC
Sequence: MSDTAEKLDYSTTLYLPQTDFPMRAGLPQKEPETVKRWQDMGLYKKLRASAAGREKFVLHDGPPYANGNIHIGHALNKILKDVITRSFQMRGFDANYVPGWDCHGLPIEWKIEEAYRARGKNKDEVPVNEFRKECRDFAAGWIKVQSEEFKRLGIEGDFENPYTTMNFHAEARIAGELLKIARSGQLYRGSKPIMWSVVERTALAEAEVEYHDVESDMIWVKFPVKDAAPALSGVSVVIWTTTPWTIPGNRAIAFSSRVEYGLFEVESAQNDFGPQTGEKLIFARKLADEAAAKAKLTFKFVRDVKSEELAAITCAHPLASLGYDFPVPLLDGDHVTDDAGTGFVHTAPSHGREDFDAWTNSVRTLEARGIDTKIPFPVDDAGFYTEDAPGFGPSAEGGAARVMDDNGKKGDANERVIKALIAANNLFARGRLKHSYPHSWRSKKPVIFRNTPQWFVYMDKELGDGTTLRSRSLDAIDQTRFVPASGQNRLRAMIEGRPDWVLSRQRSWGVPIAVFADEQGEVLVDEAVNARILEAFEAEGADAWFAEGAKERFLGNDHDHAKWQQVMDILDVWFDSGCTHTFTLEDRPDMKWPADVYLEGSDQHRGWFHSSLLESCATRGRAPYNAVVTHGFTMDEQGRKQSKSLGNVVAPQDVMKESGADILRLWVMTTDYWEDQRLGKAIIQTNIDAYRKLRNTVRWMLGTLAHDNGEEIAYADLPELEKLVLHRLSELDKVVRDGYDAFDFKKITRALIDFANVELSAFYFDIRKDTLYCDAPSSLKRRASLSVIAKLFDCLVTWLAPMLPFTTEEAWLSRYPDAESVHLAQFPEIPAEWKNDALEAKWEKIRKVRTVVTGALEVERREKRIGSSLEAAPVVHIADSDLLAALSGQDFAEICITSAITVVGDEGPADGFRLQEVAKVVVEQKLAEGVKCARSWRITTDVGSDPQYPDVSARDAAALRELAALK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.