PharMolix/UniProtQA huggingface dataset:
Protein: CCD22_RAT
Sequence: MEEADRILIHSLRQAGTAVPPEVQTLRAFTTELVVEAVVRCLRVINPDVGSGLSHLLPPAMSARFRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPAGDSAIFLRAIGSQIRDQLALPWVPPLLRTPKVQRLQGSALQQAFHSSRLVLPELNCRGEPREFQASPLLLPAPSQVPQLLGRAASLLEHHAIQLCQHVNRDCPGDEDRVRWASRLPSQEDPRAPQQRLHKQLIEHLRQSWGPLGAPTQVRDLGEMLQAWGAKAMTGVPKGSRFTHSEKFTFHLEPQVQAAQVADIPAASQRPEQDTRAAQEEELESLREQLASVNHNIEEVEANMKSLGMNLVQVETECRQSELSVAEQEQALRLKSRTVELLPDGAANLTKLQLVVESSAQRLIHLASQWEKHRVPLLAEYRHLRKLQDCRELESSRRLVEIQELHQSVRAAAEEARRKEEVYKQLVSELETLPKDVSRLAYTQRILEIVGNIRKQKEEITKILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIEDTGTIMREVRDLEEQIETEMGKKTLSNLEKICEDYRALRQENAGLLGRVREV
What is the function of this protein?
Involved in regulation of NF-kappa-B signaling.  Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex.  May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex.  Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10.  Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels.  The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1.  Plays a role in copper ion homeostasis.  Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.
What are the official names of this protein?
Coiled-coil domain-containing protein 22.
What is the protein family that this protein belongs to?
Belongs to the CCDC22 family.
What are the subcellular locations of this protein?
Endosome.
Protein: GMPAB_DANRE
Sequence: MLKAIILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMLQHHIEACAQVPDMKEIMLIGFYQPNDELNRFIYSAQQEFKIPIRYLQEFAALGTGGGIYHFRDQILSGGPAAFFLMNADVCSEFPLLEMLQFHRQHGENHCGVLLGTTANRTQSLNYGCIVENHETNEVLHFVEKPSTFVSDIINCGIYLFTPDIFAHIGKVFQRNQQEKIQEELTHGRQMPEVVRLEQDIFTALAGQKKLFVYKTQHFWSQIKSAGSAIYASRLYLKQYHQTHPERLATNQGGTPKITGDVYIHPTANIDPSAVLGPNVSIGKGVTIGGGVRVRESIILHGAVLQDHCCVLNSIVGWDSTVGKWARVEGTPSDPNPNDPYAKIDSETLFRDGGLTPSITILGCNVNIPSEVIIRNSIVLPHKDLNRSFKNQIIL
What are the official names of this protein?
Mannose-1-phosphate guanyltransferase alpha-B, GDP-mannose pyrophosphorylase A-B, GTP-mannose-1-phosphate guanylyltransferase alpha-b.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: PDUG_CITFR
Sequence: MRYIAGIDIGNSSTEVALATLDESGALSITGSALAETTGIKGTLRNVFGIQEALSLAAKNAGINVSDISLIRINEATPVIGDVAMETITETIITESTMIGHNPKTPGGVGLGVGVTITPEDLLSRPADTPYILVVSSAFDFADVATMINASVRAGYQLTGVILQQDDGVLVSNRLTHPLPIVDEVLHIDRIPLGMLAAIEVAIPGKVIETLSNPYGIATVFGLNADETKNIVPMARALIGNRSAVVVKTPSGDVKARAIPAGNLELQSQGRTVRVDVAAGAEAIMKAVGECPKLDNVTGEAGTNIGGMLEHVRQTMAELTNKPSHEIFIQDLLAVDTSVPVSVTGGLAGEFSLEQAVGIASMVKSDRLQMAMIAQEITQKLNIDVQVGGAEAEAAILGALTTPGTTRPLAILDLGAGSTDASIINPKGEIIATHLAGAGDMVTMIIARELGLEDRYLAEEIKKYPLAKVESLFHLRHEDGSVQFFPTPLPPTVFARVCVVKPDELVPLPGELALEKVRAIRRSAKERVFVTNALRALRQVSPTGNIRDIPFVVLVGGSSLDFEVPQLVTDALAHYRLVAGRGNIRGTEGPRNAVATGLILSWYKAFAHGK
What is the function of this protein?
The 1,2-PD-specific bacterial microcompartment (BMC) concentrates low levels of 1,2-PD catabolic enzymes, concentrates volatile reaction intermediates thus enhancing pathway flux and keeps the level of toxic, mutagenic propionaldehyde low.
What are the official names of this protein?
Propanediol dehydratase-reactivating factor large subunit, DDR large subunit, Propanediol utilization protein PduG.
What is the protein family that this protein belongs to?
Belongs to the DdrA/PduG family.
What are the subcellular locations of this protein?
Bacterial microcompartment.
Protein: RRG8_YEAS8
Sequence: MGLPKSAYKKLLIDCPTRVINKNCAQRVKDVSPLITNFEKWSDKRKKLYFKDEEEMVGHFHLENFNLKNNLYGRLLASPMRAEKISKLKSCRELLIPLKVVPSTGKDQHADKDKLKLVPTLDYSKSYKSSYVLNSASIVQDNLAAATSWFPISVLQTSTPKSLEVDSSTFITEYNANLHAFIKARLSVIPNVGPSSINRVLLICDKRKTPPIEIQVVSHGKGLPITQSVFNLGYLHEPTLEAIVSKDAVTKGIYLDADNDKDLIKHLYSTLLFQSVN
What is the function of this protein?
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
What are the official names of this protein?
Required for respiratory growth protein 8, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the RRG8 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS6_MYCBO
Sequence: MRPYEIMVILDPTLDERTVAPSLETFLNVVRKDGGKVEKVDIWGKRRLAYEIAKHAEGIYVVIDVKAAPATVSELDRQLSLNESVLRTKVMRTDKH
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: O10G9_HUMAN
Sequence: MSKTSLVTAFILTGLPHAPGLDAPLFGIFLVVYVLTVLGNLLILLVIRVDSHLHTPMYYFLTNLSFIDMWFSTVTVPKMLMTLVSPSGRAISFHSCVAQLYFFHFLGSTECFLYTVMSYDRYLAISYPLRYTSMMSGSRCALLATSTWLSGSLHSAVQTILTFHLPYCGPNQIQHYLCDAPPILKLACADTSANEMVIFVDIGLVASGCFLLIVLSYVSIVCSILRIHTSEGRHRAFQTCASHCIVVLCFFVPCVFIYLRPGSRDVVDGVVAIFYTVLTPLLNPVVYTLRNKEVKKAVLKLRDKVAHSQGE
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 10G9, Olfactory receptor 10G10.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MURD_STAAE
Sequence: MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVVSGSHPLTLLDNNPIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYKPHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIESEELKAKTLYFSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAIIDSLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIWLCGGLDRGNEFDELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVLLSPACASWDQYSTFEERGEKFIERFRAHLPSY
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRIZ4_DROME
Sequence: MKPTCILCLLVVILLHPRISKSSTSGNPSASSSSSSPPEIPAFRQCETIRIEMCRKIGYNETSMPNLVGNEMQTDVEYTLQTFAPLIEYDCSSQLKLFLCAAYVPMCTPKAPVHAIGPCRSLCESVRIRCHPVLQGFGFPWPPALDCDKFPRENNHETMCMEGPGELHQPQQEQDLYGLPGQGIPGGLGGKLPMDCSGLAKSHLYVRLPRSGRCAPLCEADILFTPAEKHLAEIWVSTWAYAALGLALVATVCLLASDGSRLASAKWSRLLSPLIWCHNMVTLGWAVRFMVGRTGTACGTDPQAPNESLLTVDGLSNASCASVFLMRYYFGMAACAWWAVLCLGWHRDIRRHSPDSKGHVVIPSNFGGSPAKRNSAKTAQQDLTQNNFVCFVAWGLPAFQTSAVIVARFVDADELLGACFVGNQSDKALQILVATPVFCYWIFGSMNLISGYLVHCRTKEILRNSNALSVQQQLQQLSAHSSSGIGIFLFIYGLACAMLLLAVIYEFANIDVWLGSGDTNTPLWPFLLRAFMELMLGICCFAWVLGPSISTLYKRQVSNGKMVKHTSAGAATGHLDGHSSSRGSHAACNSTVVSYHSVRTSMASVPLPPSPYKLKTSPGTGSISLNQMSNYSLGRSVHHQQRHSPHHHHHQQQQHHQFHPHHNHQHHSTSSHRLYYPPGSYASQKYSQHGSYYPHLQQYGNETLL
What is the function of this protein?
Receptor for Wnt proteins.  Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
What are the official names of this protein?
Frizzled-4, dFz4.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MRAY_BACC2
Sequence: MLEQGLLVTAGVAFLISVALSPLFIPFLRKLKFGQSIRDEGPKSHQKKSGTPTMGGIVIYVSMMVTSLIMAIKFNHLGAEVSLLLLVTFGYGLIGFLDDYIKVVKKRNLGLTSKQKLVGQLVIAIAFFLIGKGQAFHTYIMIPGTDVKFELGWAYFVLVLFMLIGGSNAVNLTDGLDGLLSGTAAIAFGAFSIIAVAQEQFGVAIFCMAVVGAVLGFLVFNANPAKVFMGDTGSLALGGAIAAVAILLKQELLLVIIGGVFVMETLSVIIQVISFKTTGKRVFKMSPLHHHYELCGWSEWRVVVTFWSVGFLLAVLGIYIGVWM
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y944_RALSO
Sequence: MSRASRHNPSYLQPVVRTDIGDEDDPGTPKSKSQRKREVTALQDLGTALEALPKDRLAKVPLPETLADALREARRITSHEGKRRQMQYIGKLMRALTDDDIEAIRRVLATFVGASKAETARLHAIERWRDRLLADDGAITEFIAAHPDTDVQALRTLVRNARKEAQLGKPPKSSRELFQAVKQALAGHDQAGEDAEPSNLEDDQA
What are the official names of this protein?
UPF0307 protein RSc0944.
What is the protein family that this protein belongs to?
Belongs to the UPF0307 family.
Protein: GRA11_GIBZE
Sequence: MNNPWELDHFREELVSVNIDAAQPQQLFLSVRGPPRTTPKQPVAIIECGAAATTRWWTVVQRLLCPTLRVYCYDRAGLGRSGHAVVFPRTASSMAFELERLFETVGVEPPFIFITHSYGAIITREFLARLPRPKQSVVGMLFVESNQEKTHQELIVSSHLSTSLSGLNSLVSTGLYEDHQYSEAEVEAILKYESGTTTNRSDKPSAAISELENMESSARALADREQLQKHILSPNPITVMRGDITRDLRRLFKTSGVMHQGAEEIESFLEHFARVDRQLQREILQLSHSARFVQAKKSGHHVEATEPELITAEVRRIVKLVR
What is the function of this protein?
AB hydrolase superfamily protein; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461).  The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable).  The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable).  The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable).  Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable).  On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable).  Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable).  The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable).  The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable).  The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).
What are the official names of this protein?
AB hydrolase superfamily protein FGSG_00044, Gramillins biosynthetic cluster protein FGSG_00044.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: PYRG_RICCN
Sequence: MVHFIFVTGGVVSSLGKGLTAASLAMLLQAKGFRVSVRKLDPYLNIDPGTMNPHEHGEVYVTDDGAETDLDLGHYERFTGVSACKFDSITTGAIYSKLLKDERLGNYAGVTVQVIPHVTNIIKDFILSNTKGFDFIICEIGGTVGDIEGLPFFEAIRQIGNKLKSENCLFIHLTLLPYVKTARELKIKPTQHSVKALRAIGISPNILVCRAERNISKGEIDKISLLCNIESEYVVPAIDQKNIYLVPIAYHNSGLDNKVLKFFNINIMPSKLDKWHDIINRLKDSNSKVRIAIIAKYHKLKDAYKSVIEALDHAGIYYKYKIDLVWINAENLTEENINKKLLDIDGILVPGGFGERATKGTIIAIKYARTNNIPFFGICFGMQLATIEIAQNLIGIKDAVTEEFKVDGTKIIEKINKNCEDSKITIENVKKTMRLGSYPCSLVASTIAANAYKSLEINERHRHRYKFNNEFQNIFEKHGIVFSGFSKDEEIVEIIELPLLRWFVGVQFHPEFKSKPFEAHPLFIQFIKAAIEYNKCN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ACKA_STRPZ
Sequence: MSKTIAINAGSSSLKWQLYQMPEEEVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDHTEAVKILLNDLIHFGIIAAYGEITGVGHRVVAGGELFKESVVVNDKVLEQIEELSVLAPLHNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLYPIPQKYYTDYKVRKYGAHGTSHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGKSVDTSMGFTPLAGPMMGTRSGDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDIEAGLQEDNPDAVLAYNIFIDRIKKCIGQYFAVLNGADALVFTAGMGENAPLMRQDVIGGLSWFGMDIDPEKNVFGYRGDISTPESKVKVLVISTDEELCIARDVERLKNTK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_STRU0
Sequence: MIDPVAIQIGPFAIHWYALCIMTGLVLAVYLSSKEAPRKKMTSDDVIDFIIIAFPIAIIGARLYYVIFEWSYYSKHLNELLAIWNGGIAIYGGLITGAIVLFIYCYYKVLNPIRFLDIIAPGVMLAQAIGRWGNFINQEAYGRVVKALPYLPSFIQKQMFIDGHYRMPTFLFESVWNIIGFTIICYLRRQKKLLLEGEVLAFYLIWYGIGRFVIEGMRTDSLIFIGLRVSQIVSIVLIILGIVFVILRRRQKGIPYYQE
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSBD_EUGGR
Sequence: MTFTDLNTENKNGWFDVADDWLKKDRFIFIGWSGLLLFPCSYLALGGWLTGITFVTSWYTHGLASSFLEGCNALTAAVSTPPNSMGHSLLLLLGSEAQWDFTRWLQIGGLWPFIALHGAFGLIGFMLRQFEIAKAVQIRPYNAIAFSAPISVFVSVFLIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTIFEDGDSPNTFRAFNPLQSEETYSMVTANRFWSQIFGVAFSNKRWLHFFMVFVPVTGLRMSALGIVGLALNLRAYDFVSQEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHEQFIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y2364_PARP8
Sequence: MTPFEFRQAVRHRDFRGPTAGHCGDYAQANLAILPAAHAHDFLRFCHANPKPCPLLGVGEPGDFRVPVLGRDIDIRTDVPAYNVYRDGELSERVESIETLWQDDFVVFAIGCSFSFEHMLAKEGIGLRHVEEGRNVPMYRTTIANRRAGVFGGELVVSMRPLRGADAIRAVQITSRFPGVHGAPVHIGDPAELGIADLARPEFGDAVTIRAGELPVYWACGVTPQTALMAAKLPLAIAHAPGHMLMTDITNASLAIF
What are the official names of this protein?
Putative hydro-lyase Bphy_2364.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: Y2306_THEVB
Sequence: MVGNCQSVPMIGVATGAAIAGAWSDRHRQPPTFPALVCVLGFTETALIPGISAAGQTPSDRQITALADGEFLLRGIQPQYHYALPPLTAGASPALISRALIEALALPLYVFDAGLPLPRLPEMIDLGGTPARCLTTGQAMTPQMVAHLWEQGWSWGAKLSSQYPWLIIAECVVGGTTTALALCESLGIPARDCVGSSHRQSNHTQKWSLVQKGLAHLPPQADPFTCVAAIGDPMQVVVAAMALRASQTCGVLLAGGSQMIAVYAFGRAIAQWRQLPWRPEQIVVGTTRWLIEDQTAQIHRLAERVQCPLIYTQLDFSLSRHPALRAYEQGFVKEGVGAGGCAIAGHLLAGWRNSEMVDIVDRLADRWAKGM
What are the official names of this protein?
UPF0284 protein tll2306.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: ACP_AZOBR
Sequence: MSDVAERVKKIVVDHLGVEESKVTENASFIDDLGADSLDTVELVMAFEEEFGCEIPDDAAEKILTVKDAIDFIKANAAA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLCA_SALPK
Sequence: MKTDTSTFLAQQIVRLRRRDQIRRLMQRDKTPLAILFMAAVVGTLTGLVGVAFEKTVSWVQNMRIGALVQVADHAFLLWPLAFILSALLAMVGYFLVRKFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFIGGMGTLGAGMVLGREGPTVQIGGNLGRMVLDVFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAPIIEVGKLSDAPVNTLWLYLILGIIFGCVGPVFNSLVLRTQDMFQRFHGGEIKKWVLMGGAIGGLCGILGLIEPAAAGGGFNLIPIAAAGNFSVGLLLFIFITRVVTTLLCFSSGAPGGIFAPMLALGTLLGTAFGMAAAVLFPQYHPEAGTFAIAGMGALMAASVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILARTLAKQDAEQAAKNQNAPAGENT
What is the function of this protein?
Proton-coupled chloride transporter.  Functions as antiport system and exchanges two chloride ions for 1 proton.  Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
H(+)/Cl(-) exchange transporter ClcA.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TPC6A_HUMAN
Sequence: MADTVLFEFLHTEMVAELWAHDPDPGPGGQKMSLSVLEGMGFRVGQALGERLPRETLAFREELDVLKFLCKDLWVAVFQKQMDSLRTNHQGTYVLQDNSFPLLLPMASGLQYLEEAPKFLAFTCGLLRGALYTLGIESVVTASVAALPVCKFQVVIPKS
What is the function of this protein?
May play a role in vesicular transport during the biogenesis of melanosomes.
What are the official names of this protein?
Trafficking protein particle complex subunit 6A, TRAPP complex subunit 6A.
What is the protein family that this protein belongs to?
Belongs to the TRAPP small subunits family. BET3 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.
Protein: THYX_BPPHC
Sequence: MKVNVLATTALNPSPLLDAYEYRVSGAAYNRDRPTDADALGEAAGRICYKSFERKNPATASNPGYLGNILAQGHFSVLEHASVTFLVRDVSRALLTELSRHRHLSFSVVSQRYVDHADTEPVVPPAIRGTELEKPFREDYAEALQAYDAGVKLLRARGYGRKQAREAARALLPNAAPVDMVVTGNLRAWRDVLGKRWHVAADAEIREFAGRVLDHLHAVAPNSVQDMPTSPFGSDGK
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Probable flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Gp16.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: Y150_LACLM
Sequence: MSFTDETVRFEFGDSDKKEIGETLVDVYNVLEAKGYNPINQIVGYVLSGDPAYIPRHDDARNKIRRFDRDDIVEELIKNYLKDNGVNL
What are the official names of this protein?
UPF0297 protein llmg_0150.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: PHOU_ECOLI
Sequence: MDSLNLNKHISGQFNAELESIRTQVMTMGGMVEQQLSDAITAMHNQDSDLAKRVIEGDKNVNMMEVAIDEACVRIIAKRQPTASDLRLVMVISKTIAELERIGDVADKICRTALEKFSQQHQPLLVSLESLGRHTIQMLHDVLDAFARMDIDEAVRIYREDKKVDQEYEGIVRQLMTYMMEDSRTIPSVLTALFCARSIERIGDRCQNICEFIFYYVKGQDFRHVGGDELDKLLAGKDSDK
What is the function of this protein?
Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis.  Encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon.  PhoU is essential for the repression of the Pho regulon at high phosphate conditions.  In this role, it may bind, possibly as a chaperone, to PhoR, PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB, or inhibit formation of the PhoR-PhoB transitory complex.  Is also part of complex networks important for bacterial virulence, tolerance to antibiotics and stress response.
What are the official names of this protein?
Phosphate-specific transport system accessory protein PhoU, Pst system accessory protein PhoU, Negative regulator of Pho regulon.
What is the protein family that this protein belongs to?
Belongs to the PhoU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LMUA_BACX1
Sequence: MIEIDNGGAIALKGFNYQKASIILVMIHNFEKDNFIVIPESQEDFEIHLGQDTYFIQVKGTKKLSIGKLKSRPSGKASIIEKNLSPGNVGDIRKIFLWDIAELTKNELISQEGTLIPMKHSLSLKQKTEIINTLDLDEEQKNRMNNQYIYITPFPNDINLALTFLKGEMVNENLLVSNDRAKLVLGELSLEIDRKSEIVVSTESDVERKKIDGNYLKQVFINIKQKEMFDEILDNLSINTIMKKKVKKEKLRIPLLYQNIKEQTKQKADINLLMRENDEGAINYLRDLLVEIVPDMKPTELSIALAIDCFCELGE
What is the function of this protein?
Component of antiviral defense system Lamassu type I, composed of LmuA and LmuB.  Expression of Lamassu type I in B. subtilis (strain BEST7003) confers resistance to phages phi3T, SpBeta and SPR.
What are the official names of this protein?
Lamassu protein LmuA.
Protein: MURC_HELPY
Sequence: MLETPKVLLKNLQDCKIHFIGIGGIGISGLAKYLKAQGATISGSDIAISPSVKYLKALGVEINIPHDPKAINNQDVIIHSAIIKEDNKEIQRAKELEIPILSRKDALYSILKDKRVFSVCGAHGKSSITAMLSAICPSFGAIIGAHSKEFDSNVRESANDSLVFEADESDSSFLFSNPYAAIVPNTEPEHLEHYGHDLERFFFAYEYFLDHAQKRVIYKEDPFLKNYSKNAIVLEKKDIYNIQYILKDGEPYTSFELKDLGAFLVWGLGEHNATNASLAILSALDELHLEEIRNNLLNFKGIKKRFDILQKNALILIDDYAHHPTEISATLKSARIYANLLNTQEKIIVIWQAHKYSRLMDNLEEFKKCFSEHCDRLIILPVYSASEVKRDIDLKAHFKHYNPTFIDRVRKKGDFLELLVNDNVVETIEKGFVIGFGAGDITYQLRGEM
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.