PharMolix/UniProtQA huggingface dataset:
Protein: RISB_RHOER
Sequence: MVMSEIQGQRIAFIQATWHRNIVDRARDGFTDAIVELGYPKDTVDFFEVPGAFEIPLHARRLAKTGRYQAIVAAGLVVDGGIYRHDFVATAVIDGLMRVQLDTDVPVFSVVLTPHHFHEHAEHVDYFSTHFVKKGAEAARAVDATVKSLKALPTS
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: Y1241_BURPS
Sequence: MIIVLSPAKSLDYETPPHVSHHTQPQFADDAAALIDELRRLSPQQIATLMSISDPLARLNFQRYADWSRASTPANAKQAVLAFNGDVYEGLDARSLSPDDLDYAQRHVRVLSGLYGLLRPLDLLQPYRLEMGTRFSNARGKDLYAFWGERITHALNAELKTRVGASRVLVNCASAEYFKSVKPKLLDARVVTPVFEDWKDGRYKIISFHAKRARGLMARYVVEGRIDSPDALKDFASEGYAFDASASNDDTYVFRRRAGA
What are the official names of this protein?
UPF0246 protein BPSL1241.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: VP2_POVJC
Sequence: MGAALALLGDLVATVSEAAAATGFSVAEIAAGEAAATIEVEIASLATVEGITSTSEAIAAIGLTPETYAVITGAPGAVAGFAALVQTVTGGSAIAQLGYRFFADWDHKVSTVGLFQQPAMALQLFNPEDYYDILFPGVNAFVNNIHYLDPRHWGPSLFSTISQAFWNLVRDDLPALTSQEIQRRTQKLFVESLARFLEETTWAIVNSPANLYNYISDYYSRLSPVRPSMVRQVAQREGTYISFGHSYTQSIDDADSIQEVTQRLDLKTPNVQSGEFIERSIAPGGANQRSAPQWMLPLLLGLYGTVTPALEAYEDGPNKKKRRKEGPRASSKTSYKRRSRSSRS
What is the function of this protein?
Viroporin inducing perforation of cellular membranes to trigger virus progeny release.  Forms pores of 3 nm inner diameter.  VP4 is expressed about 24 hours after the late structural proteins and is not incorporated into the mature virion (By similarity).
What are the official names of this protein?
Minor capsid protein VP2, Minor structural protein VP2.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses capsid protein VP2 family.
What are the subcellular locations of this protein?
[Isoform VP2]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane. SUBCELLULAR LOCATION: [Isoform VP3]: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane. SUBCELLULAR LOCATION: [Isoform VP4]: Host nucleus.
Protein: DMS3_PITAZ
Sequence: MAFLKKSLFLVLFLGMVSLSICEEEKRENEDEEKQEDDEQSEMKRGLWSTIKNVAAAAGKAALGALGEQ
What is the function of this protein?
Possesses a potent antimicrobial activity against Gram-positive and Gram-negative bacteria.  Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).
What are the official names of this protein?
Dermaseptin-H3, Dermaseptin-like peptide 3, DMS3.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: APT_HERA2
Sequence: MSLDLTQFVRNIPDFPIPGVQFKDITPLLGNAQAFDAAIEHFAQRYANQQLQAIVGIESRGFIFGAPLALRLGIGFVPIRKPGKLPAQTIGVDYSLEYGTNRLEIHNDALQAGDRVVVVDDLLATGGTVVAACDLLNQLGAEVVEAAFLIELTFLGGREKLGNRPFYAQIQY
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYA_SHIB3
Sequence: MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEMEAVINKTCAEILHGISAEELEQLITLIAKLEHNIIELQAKG
What is the function of this protein?
Transcription regulator that can specifically activate or repress expression of target genes.
What are the official names of this protein?
Transcriptional regulator SlyA.
What is the protein family that this protein belongs to?
Belongs to the SlyA family.
Protein: PYRG_RUBXD
Sequence: MSGTKYIFVTGGVVSSIGKGTSAAALGMLLKSRGYRVVLQKFDPYINVDPGTMNPYQHGEVFVTEDGAETDLDLGHYERFLDENLGRLSNVTTGSVYWEVISRERRGDYLGATVQVIPHITNEIKARIGRLGREKDVVITEIGGTVGDIESQPFLEAIRQFRNDVGRKNVLYVHVSYVPYIEAAGELKTKPTQHSTQRLREMGISPDILICRADRPIGEEIRRKIALFGDVEVDSVIPAQDAPTLYDIPLSLHGSGLDALVLEKLGLPAPPARLEEWRGLVRRLHGAEREVRVAVIGKYIRLQDAYLSVVEALRHAGGAHEVRVELDWVDSEQISDPEAARERLRGADGVLVLHGFGQRGIEGKIEAARYARESGTPYLGLCLGMQIAVIEFARNVAGLEMANSTEFDEETPHPVIDIMPDQVGVEMGGTMRLGSYPCRLRPGTLAARVYGAEVVHERHRHRYEVNNAYREVLEEAGMVFSGTSPDGRLVEIAELAGHPFFIGSQFHPEFKSRPLRPHPLFRGFVGACLGAAEEAGRVTAPAAGRKDGASG
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: ZOX_PHAVU
Sequence: MALNDETKVVVLLLPFPVQGHLNPFLQLSHLIAAQNIAVHYVGTVTHIRQAKLRYHNATSNIHFHAFEVPPYVSPPPNPEDDFPSHLIPSFEASAHLREPVGKLLQSLSSQAKRVVLINDSLMASVAQDAANFSNVERYCFQVFSALNTAGDFWEQMGKPPLADFHFPDIPSLQGCISAQFTDFLTAQNEFRKFNNGDIYNTSRVIEGPYVELLERFNGGKEVWALGPFTPLAVEKKDSIGFSHPCMEWLDKQEPSSVIYVSFGTTTALRDEQIQELATGLEQSKQKFIWVLRDADKGDIFDGSEAKRYELPEGFEERVEGMGLVVRDWAPQMEILSHSSTGGFMSHCGWNSCLESLTRGVPMATWAMHSDQPRNAVLVTDVLKVGLIVKDWEQRKSLVSASVIENAVRRLMETKEGDEIRKRAVKLKDEIHRSMDEGGVSRMEMASFIAHISR
What is the function of this protein?
Utilizes UDP-xylose as the sugar donor and catalyzes the formation of o-xylosylzeatin from zeatin.  Does not act on UDP-glucose.
What are the official names of this protein?
Zeatin O-xylosyltransferase, Zeatin O-beta-D-xylosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: ZMY15_HUMAN
Sequence: MEFVSGYRDEFLDFTALLFGWFRKFVAERGAVGTSLEGRCRQLEAQIRRLPQDPALWVLHVLPNHSVGISLGQGAEPGPGPGLGTAWLLGDNPPLHLRDLSPYISFVSLEDGEEGEEEEEEDEEEEKREDGGAGSTEKVEPEEDRELAPTSRESPQETNPPGESEEAAREAGGGKDGCREDRVENETRPQKRKGQRSEAAPLHVSCLLLVTDEHGTILGIDLLVDGAQGTASWGSGTKDLAPWAYALLCHSMACPMGSGDPRKPRQLTVGDARLHRELESLVPRLGVKLAKTPMRTWGPRPGFTFASLRARTCHVCHRHSFEAKLTPCPQCSAVLYCGEACLRADWQRCPDDVSHRFWCPRLAAFMERAGELATLPFTYTAEVTSETFNKEAFLASRGLTRGYWTQLSMLIPGPGFSRHPRGNTPSLSLLRGGDPYQLLQGDGTALMPPVPPHPPRGVFGSWQDYYTWRGLSLDSPIAVLLTYPLTVYYVITHLVPQSFPELNIQNKQSLKIHVVEAGKEFDLVMVFWELLVLLPHVALELQFVGDGLPPESDEQHFTLQRDSLEVSVRPGSGISARPSSGTKEKGGRRDLQIKVSARPYHLFQGPKPDLVIGFNSGFALKDTWLRSLPRLQSLRVPAFFTESSEYSCVMDGQTMAVATGGGTSPPQPNPFRSPFRLRAADNCMSWYCNAFIFHLVYKPAQGSGARPAPGPPPPSPTPSAPPAPTRRRRGEKKPGRGARRRK
What is the function of this protein?
Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs).  May be important for spermiogenesis.
What are the official names of this protein?
Zinc finger MYND domain-containing protein 15.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ARFD_DICDI
Sequence: MGISSSNPFSSIFKSKAIKLLMLGLDGSGKTTILYKLMLNEVVSTISTLGYNVETIQHKHLNLTLWDLAGEERIRTLWKPFYNKCTAIIFVVDSSDRLRIDEAASELAKLMKEEELKGCSLLIFATKQDCISPMEIPELTDQLGLHDIKDRRWYVQPTRTLEGIGIYEGLDWLSTKIIEDRKSKSFKSKFSFSNKSKQQKSNSQPNTPRKNIQMMT
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor D.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: TRPF_STRMK
Sequence: MSRSYYRTRIKFCGMTRAGDVRLAGELGVDAVGFIFARESSRRVAPAEARAMRQAIAPMVDVVALFRNNSKEEVREVLRTVRPTLLQFHGEEDESFCRSFNMPYLKAIAMGGREEVNARTLQLRYPSAAGFLFDSHAPGGGGGTGVAFDWGRIPTGLHRPFLLAGGLNPENVYDAVLATLPWGVDVSSGIELEPGIKDGYRMRTFVEEVRRADCTVLE
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: Y1856_STRPQ
Sequence: MEGIFYALIPMFTWGSIGFVSNKIGGKPSQQTLGMTFGALLFSLAVWLIVRPEMTLQLWLFGILGGFIWSIGQTGQFHAMQYMGVSVANPLSSGSQLVLGSLIGVLVFHEWTRPMQFVVGSLALLLLIVGFYFSSKQDDANAQVNHLHNFSKGFRALTYSTIGYVMYAVLFNNIMKFEVLSVILPMAVGMVLGAITFMSFKISIDQYVIKNSVVGLLWGIGNIFMLLAASKAGLAIAFSFSQLGAIISIVGGILFLGETKTKKEMRWVVTGIICFIVGAILLGVVKS
What are the official names of this protein?
Putative sugar uptake protein SPs1852.
What is the protein family that this protein belongs to?
Belongs to the GRP transporter (TC 2.A.7.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RECA_RHILO
Sequence: MAQNSLRLVEDKAVDKSKALDAALSQIERAFGKGSIMRLGANEQVVEIETVPTGSLGLDIALGVGGLPRGRIIEIYGPESSGKTTLALHTVAEAQKKGGICAFVDAEHALDPVYARKLGVDLENLLISQPDTGEQALEICDTLVRSGAIDVLVVDSVAALTPRAEIEGEMGDSLPGLQARLMSQALRKLTASISRSNTMVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGSVKDRDEVVGNQTRVKVVKNKLAPPFKVVEFDIMYGEGVSKTGELVDLGVKAGVVEKSGAWFSYNSQRLGQGRENAKLFLRDNPDTAREIELALRQNAGLIAEKFLENGGSEGGDDGFEDEAGAM
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCRI_PROMM
Sequence: MTQMTSSDVPGMGRRQFMNLLTFGSVTGVALGSLYPVVKYFIPPRASGSGGGTSAKDELGNSVTASGWLANHSDGDRSLVQGLKGDPTYLIVEGDDAIGSYGINAICTHLGCVVPWNSGVNKFVCPCHGSQYNSTGKVVRGPAPLSLALANIAVENDNVFVSQWTETDFRTGEKPWWT
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex iron-sulfur subunit, Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein, ISP, RISP, Rieske iron-sulfur protein.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein. Note=The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.
Protein: MMAA_RABIT
Sequence: MAMLLPHPHPDFLKGLLKAPFRCYRFIFHSSTHLGSGIPCAQPFNLLGLHYAKWMLLSDGLKRNLCVQTTLKDHKEGLSDKGQRFVDKLFTGLIQGQRACLAEAKTLVESTHSRKKELAQVLLQKVLLFQREQEQPNKGNPLAFRLGLSGPPGAGKSTFIEYSGKLLTERGHKLSVLAVGPSSCNSGGSLLGDKTRMTEFSRDMNAYIRPSPTRGNLGGVPRTTNEVILLCEGAGYDIILIETVGVGQSEFAVADTVDILFYYCHQLEEMNCRVSKEVYLRWQHGSNNYVCWRLDCASSKDTGRVCDALKLLRRRLAVWRPKVVRISARSWRGGHWNVGYDARILGPNTCQRGAACQTTKATESLDVEPHSGKRVRAFQESPHSPGADSCSGTKGPPWGPGPRASSRFVVEGF
What is the function of this protein?
GTPase, binds and hydrolyzes GTP (By similarity).  Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (By similarity).  Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (By similarity).  Plays a dual role as both a protectase and a reactivase for MMUT (By similarity).  Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (By similarity).  Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (By similarity).
What are the official names of this protein?
Methylmalonic aciduria type A homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: PE2R4_MOUSE
Sequence: MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
What is the function of this protein?
Receptor for prostaglandin E2 (PGE2).  The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase.  Has a relaxing effect on smooth muscle.  May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
What are the official names of this protein?
Prostaglandin E2 receptor EP4 subtype, PGE receptor EP4 subtype, PGE2 receptor EP4 subtype, Prostanoid EP4 receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: U7E12_ARATH
Sequence: MQVLGMEEKPARRSVVLVPFPAQGHISPMMQLAKTLHLKGFSITVVQTKFNYFSPSDDFTHDFQFVTIPESLPESDFKNLGPIQFLFKLNKECKVSFKDCLGQLVLQQSNEISCVIYDEFMYFAEAAAKECKLPNIIFSTTSATAFACRSVFDKLYANNVQAPLKETKGQQEELVPEFYPLRYKDFPVSRFASLESIMEVYRNTVDKRTASSVIINTASCLESSSLSFLQQQQLQIPVYPIGPLHMVASAPTSLLEENKSCIEWLNKQKVNSVIYISMGSIALMEINEIMEVASGLAASNQHFLWVIRPGSIPGSEWIESMPEEFSKMVLDRGYIVKWAPQKEVLSHPAVGGFWSHCGWNSTLESIGQGVPMICRPFSGDQKVNARYLECVWKIGIQVEGELDRGVVERAVKRLMVDEEGEEMRKRAFSLKEQLRASVKSGGSSHNSLEEFVHFIRTL
What is the function of this protein?
Possesses quercetin 3-O-glucosyltransferase and 7-O-glucosyltransferase activities in vitro.
What are the official names of this protein?
Flavonol 3-O-glucosyltransferase UGT76E12, Flavonol 7-O-beta-glucosyltransferase UGT76E12, UDP-glycosyltransferase 76E12.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
Protein: POLK_ARATH
Sequence: MDNGESSSTNNSSRPWESYNTVFTNAKAGMEGVDKEKVQRVVYEMSKGSKYFQNEERKEALMKQKIEHMRDRCAKLSSLDLSNYQKVVDKRILELEATRDLSRIWLHVDMDAFYAAVETLSDPSIKGKPMAVGGLSMISTANYEARKFGVRAAMPGFIARKLCPDLIFVPVDFTKYTHYSDLTRKVFRNYDPHFIAGSLDEAYLDITEVCRERGLSGGEIAEELRSSVYSETGLTCSAGVAANRLLAKVCSDINKPNGQFVLQNDRSTVMTFVSFLPVRKIGGIGKVTEHILKDALGIKTCEEMVQKGSLLYALFSQSSADFFLSVGLGLGGTNTPQVRSRKSISSERTFAATGDERLLYSKLDELAEMLSHDMKKEGLTARTLTLKLKTASFEIRSRAVSLQRYTCSSDDILKHATKLLKAELPVSVRLIGLRMSQFVEEIRNSDPSQGTITKFIVQKDSSRQAQDLDDNDSFDLDANKNCLSNDESGNVSFGSHETSSAHLKDVVEYEERSQIDSGKVIPNQECMKKEERLQILEGDSLLKKYKECKPDTSHSMNDNSNATEAVSVFPQTEPLYWIDGYKCVLCGIELPPSFVEERQEHSDFHLAQRLQNEETGSSSSTTPSKRRILGKEKVNSKPKKQKPDQKDSSKHIPIHAFFTKSNQNSNETQRK
What is the function of this protein?
Template-directed low-fidelity DNA polymerase specifically involved in DNA repair (PubMed:15200644, PubMed:17550419).  Able to extend primer-terminal mispairs, and to insert nucleotides opposite to a single 7,8-dihydro-8-oxoGuanine (8-oxoG) lesion and moderately extend from the resulting primer end, thus leading to both error-free and error-prone bypass of 8-oxoG DNA lesions (PubMed:17550419).  Probably involved in consecutive DNA replication cycles in the absence of mitosis (PubMed:15200644).  Binds preferentially template-primer DNA substrates or single-stranded DNA (PubMed:17550419).  Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls.  Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts (By similarity).
What are the official names of this protein?
DNA polymerase kappa, AtPOLK.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Nucleus. Note=Detected throughout the nucleus and at replication foci.
Protein: MIND_BUCBP
Sequence: MTRIIVVTSGKGGVGKTTSSAALATGFAKKGKKTVVIDFDIGLRNLDLIMGCERRVVYDFINVINGEAILNQALIKDKRTEGLFILPASQTRNKNALTKSGIDRVFTQLVNMNFDIIICDSPAGIESGAVLAIYFSDEAIVITNPEVSSVRDSDRILGIIASTSQRSSQNFKPIKEHLLLTRYNPKRVSNGDMLSTEDVLDILRIPLIGVIPEDTSVLKASNQGTPVILNYNSNAGQAYYDTVNRLLGINCPFRFVKDEKKSFLRRLFRR
What is the function of this protein?
ATPase required for the correct placement of the division site.  Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity).
What are the official names of this protein?
Septum site-determining protein MinD, Cell division inhibitor MinD.
What is the protein family that this protein belongs to?
Belongs to the ParA family. MinD subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PCHF_PSEAB
Sequence: MSLGELLETCRSRRIELWSEAGRLRYRAPQGALDAGLAERLRAEREALLEHLEGGPGWRAEPDLAHQRFPLTPVQAAYVLGRQAAFDYGGNACQLYAEYDWPADTDPARLEAAWNAMVERHPMLRAVIEDNAWQRVLPEVPWQRLTVHACAGLDEAAFQAHLERVRERLDHACAALDQWPVLRPELSIGRDDCVLHCSVDFTLVDYASLQLLLGEWRRRYLDPQWTAEPLEATFRDYVGVEQRRRQSPAWQRDRDWWLARLDALPGRPDLPLRAQPDTRSTRFRHFHARLDEAAWQALGARAGEHGLSAAGVALAAFAETIGRWSQAPAFCLNLTVLNRPPLHPQLAQVLGDFTALSLLAVDSRHGDSFVERARRIGEQMFDDLDHPTFSGVDLLRELARRRGRGADLMPVVFTSGIGSVQRLLGDGEAPRAPRYMISQTPQVWLDCQVTDQFGGLEIGWDVRLGLFPEGQAEAMFDDFVGLLRRLAQSPRAWTDGDATEPVEAPPQALPGSARSIAAGFAERALLTPDATVIHDAAGSYSYRQVAQHASALRRVLEAHGAGRGRRVAVMLPKSAAQLVAVIGILQAGAAYVPVDIRQPPLRRQAILASPEVVAWVCLESDVPNAGCACVAIDRLAADSAWPPPPAAEVAADDLAYVIYTSGSTGTPKGVMLSHAAVSNTLLDINQRYGVDANDRVLGLAELSFDLSVYDFFGATAAGAQVVLPDPARGSDPSHWAELLERHAITLWNSVPAQGQMLIDYLESEPQRHLPGPRCVLWSGDWIPVSLPTRWWRRWPDSALFSLGGATEAAIWSIEQPIRPQHTELASIPYGRALRGQSVEVLDARGRRCPPGVRGEIHIGGVGLALGYAGDPQRTAERFVRHPDGRRLYRTGDLGRYLADGSIEFLGREDDQVKIRGHRIELAELDAALCAHPQVNLAATVVLGETHERSLASFVTLHAPAEAGEDPRTALDTVRQRAAQALRRDWGSEEGIAAAVAALDRACLASLAAWLAGSGLFASATPLDFATLCQRLGIAEARQRLLRHWLRQLEEGGYLRAEGEGWLGCAERPAQSPEDAWTAFAGCAPAALWPAELVAYLRDSAQSLGEQLAGRISPAALMFPQGSARIAEAMYSQGLHAQALHEAMAEAIAAIVERQPQRRWRLLELGAGTAAASRAVIARLAPLVQRGTEVDYLFTDVSSYFLAAARERFADQPWVRFGRFDMNGDLLDQGVAPHSVDILLSSGALNNALDTPALLAGLRELLSADAWLVIQELTREHNEISVSQSLMMENPRDLRDERRQLFVHTGQWLEWLAAQGGDLACGVVPPGSALDLLGYDVLLARCKTDRARLEPAELLAFVEARVPRYMLPAQLRVLERLPVTGNGKIDRKALTGFARQPQADLRHGVAQAPADELESALLALWREVLDNPSLGVEQDFFGAGGDSLLIAQLIARLRERLESARRHPFDRLLRWALSQPTPRGLAERLRSAPEEGRGPALAAARGVAPAQTGMSRAPLAEGAVALDPLVRLVPGEGVPRVLVHEGLGTLLPYRPLLRALGEGRPLLGLAVHDSDAYLAIPAEYLNACLGRRYAEALHGAGLREVDLLGYCSGGLVALETAKSLLQRGVRVRQLDIVSSYRIPYRVDDERLLLFSFAATLGLDTAALGFPAPERLGQAVQAALAQTPERLGAEALAGLPGLADLVALRGRVLQAASGSADAASVERDTLYRLFCHSVRASQAEALEPYVGALRLFVPDAGNPLVPRYAEALETQWRAAALGACGIHEVPGGHFDCLGEALAQSLSKPMPEEASQ
What is the function of this protein?
Involved in the biosynthesis of the siderophore pyochelin (PubMed:10555976).  Adenylates L-cysteine and loads it onto its peptidyl carrier domain via a thioester linkage to the phosphopanthetheine moiety (PubMed:10555976).  Then forms a peptide bond between the salicyl-thiazolinyl intermediate bound to the second carrier domain of PchE and the cysteine bound to its own peptidyl carrier domain to form the salicyl-thiazolinyl-cysteinyl-S-PCP2 intermediate.  It subsequently cyclizes the C-terminal cysteine to form the second thiazoline heterocycle in the salicyl-thiazolinyl-thiazolinyl-S-PCP2 intermediate (PubMed:10555976).  When this intermediate is released by the action of a thioesterase, it produces the tricyclic acid hydroxyphenyl-thiazolyl-thiazolinyl-carboxylic acid (HPTT-COOH), an advanced intermediate containing the aryl-4,2-bis-heterocyclic skeleton of the bithiazoline class of siderophores (PubMed:10555976).
What are the official names of this protein?
Pyochelin synthase PchF, L-cysteine--[L-cysteinyl-carrier protein] ligase, Nonribosomal peptide synthase PchF.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: RIB7_ARCFU
Sequence: MRPYVFVNVAASLDGKISDESRKQLRISCEEDLRIVDRLRAESDAIMVGIGTVLADDPRLTVKSAELREKRQKDGKEPNPLRVVVDSRCRVPLTARILNDEARTLVAVSRIAPEEKVREVKKVAEVAVFGEERVELSALLEFLHRKGVRRLMVEGGGTLISSLISQNLVDEIRIYYGPIFIGGRDSPTVCDGESFLKKCRIEKIERIGEGFAVTARFNR
What is the function of this protein?
Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.
What are the official names of this protein?
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, DAROPP reductase, DARP reductase, 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase, 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase, DARIPP synthase.
What is the protein family that this protein belongs to?
Belongs to the HTP reductase family.
Protein: VTI1A_MOUSE
Sequence: MSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEARELLEQMDLEVREIPPQSRGMYSNRMRSYKQEMGKLETDFKRSRIAYSDEVRNELLGDAGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETEQIGQEMLENLSHDREKIQRARDRLRDADANLGKSSRILTGMLRRIIQNRILLVILGIIVVIAILTAIAFFVKGH
What is the function of this protein?
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane.  These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers.  Involved in vesicular transport from the late endosomes to the trans-Golgi network.  Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2.  May be concerned with increased secretion of cytokines associated with cellular senescence.
What are the official names of this protein?
Vesicle transport through interaction with t-SNAREs homolog 1A, Vesicle transport v-SNARE protein Vti1-like 2, Vti1-rp2.
What is the protein family that this protein belongs to?
Belongs to the VTI1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type IV membrane protein.
Protein: KDSB2_BURCM
Sequence: MTSFNDGRTVRVVIPARYGSTRLPGKPLVDLDGEPMIVRVHARVRRALPDADIVVAIDDARIAEVLDARGIRFAMTDTGHASGTDRAAEVARVSGWPDTDAVLNVQGDEPLVPTALLQAFAGFCGAAPDLGVATVACPIDEVALLDEPAIVKVVVDHRGRALYFSRAAIPFCRDGRPADSAGSHGLFLRHIGLYGYANATLQALASAAPCELEQLEKLEQLRALWLGMPIDVMRWPDAPPAGIDTPDDVARVVSLLKRQTHDATEPY
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase 2, CMP-2-keto-3-deoxyoctulosonic acid synthase 2, CKS 2, CMP-KDO synthase 2.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_NOSS1
Sequence: MKISQAVGNACTVPASSVETHNNNPSKESKIIYLPGTNCEIKSQALLSAFTSYRVGGAAELYVAPRNIEALQASLRYAQEHNLRVTTLGAGSNLLVSDRGISGLVIATRHLRYTHFDHQTGQVTIAAGESIPSLAWEIAKLGWQGFEWAVGIPGTVGGAVVMNAGAHNSCIADILVSAQVLSPDGTVETLTPEELGYAYRTSLLQGSNRVVTQATFQLQPGFDPAYVTATTKQHKQMRLTTQPYNFPSCGSVFRNPKPYSAGWLIEQSGLKGYQIGGAQVAHLHANFIVNRGGAKANDIFCLIRHIQQEVQERWSILLEPEVKMLGEFQAA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.