PharMolix/UniProtQA huggingface dataset:
Protein: LOLB_SALDC
Sequence: MTLPDFRLIRLLPLASLVLTACTLPGHKGPGKSPDSPQWRQHQQEVRHLNQYQTRGAFAYISDDQKVYARFFWQQTGQDRYRLLLTNPLGSTELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLTGMPIPLNSLRQWILGLPGDATDYKLDDQYRLSEVNYRQDGKNWKVVYGGYDSKTQPAMPANMELSDGSQRIKLKMDNWIVK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RLMN_CAMHC
Sequence: MKNLLDFSLDELGELLKPKFRAKQIYEWIYHKNVDDFLQMKNLPLQMREDLANEFYIGGLNVSKCEQSVDGSKKYLFELKDGKTIESVLLPMKDEITDENGEILRHKRYTICVSSQVGCKIGCAFCLTAKGGFVRNLSAGEIVEQIRLIKKINKIPYERRINVVYMGMGEPLNNLENVAKAIKILIQNEGLAISPRRQTISTSGLSSQIKKLGEMNLGVLLAISLHAVNDELREKLMPINRAYNIASIMQAVREFPIDLRKRVMFEYLVMDGVNDSINDAKTLVRLLNGIKAKVNLIYFNPHIGSKFHRPSEENMIKFQDYLSVHGITCTIRQSKGLDISAACGQLREKNLKEKNDNA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECE1_MOUSE
Sequence: MRTVWSPLAAALAALGMSTYKRATLDEEDLVDSLSEGDVYPNGLQVNFRSSRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLAALGIQYQTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAVIKHLLENATASVSEAERKAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLRQVSTLINNTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCIPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW
What is the function of this protein?
Converts big endothelin-1 to endothelin-1.
What are the official names of this protein?
Endothelin-converting enzyme 1, ECE-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M13 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: PXN_ARATH
Sequence: MSDALINGLAGAGGGIIAQLLTYPLQTVNTRQQTERDLKREKRKLGTIEHMCQVVKQEGWERLYGGLAPSLAGTAASQGVYYYFYQVFRNRAEATALARKKKGLGDGSVGMFASLLVAAFAGSVNVLMTNPIWVIVTRMQTHRKMTKDQTAAPESPSSNAEALVAVEPRPYGTFNTIREVYDEAGITGFWKGVIPTLIMVSNPSMQFMLYETMLTKLKKKRALKGSNNVTALETFLLGAVAKLGATVTTYPLLVVKSRLQAKQVTTGDKRQQYKGTLDAILKMIRYEGLYGFYKGMSTKIVQSVLAAAVLFMIKEELVKGAKLLLSNATSS
What is the function of this protein?
Mediates the NAD(+) import into peroxisomes.  Favors the NAD(+)(in)/AMP(out) antiport exchange, but is also able to catalyze a low unidirectional transport that might be essential under special conditions.  Transports CoA, dephospho-CoA, acetyl-CoA, adenosine 3',5'-diphosphate (PAP), NAD(+), AMP, ADP and NADH, but has no activity with ATP, GTP, GDP, NADPH, NADP(+) or FAD.  Required for peroxisomes proliferation.
What are the official names of this protein?
Peroxisomal nicotinamide adenine dinucleotide carrier, Peroxisomal NAD carrier, Peroxisomal membrane protein 38, (PMP36), AtPMP38, Protein ABERRANT PEROXISOME MORPHOLOGY 3, Solute carrier family 25 member 17.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Glyoxysome membrane; Multi-pass membrane protein.
Protein: UB2V1_BOVIN
Sequence: MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN
What is the function of this protein?
Has no ubiquitin ligase activity on its own.  The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.  This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome.  Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.  Mediates transcriptional activation of target genes.  Plays a role in the control of progress through the cell cycle and differentiation.  Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).  Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity).  Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (By similarity).  UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2 variant 1, UEV-1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus. Note=Excluded from the nucleolus.
Protein: Y1894_LACPL
Sequence: MESWLFLLAILVVAWLGKNQSLQIATVVVLLIKLIPNTSKLLTTIGQKGINWGVTVITVAILIPIATGQIGFRDLWHAFKSPVGWIAVACGVLVSVLSFHGVGLLSATPEITVALVFGTIMGVVLLKGIAAGPIIAAGITYCIIQVLHLSLQ
What are the official names of this protein?
UPF0756 membrane protein lp_1894.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRMD_ECO7I
Sequence: MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK16_ACOCL
Sequence: MLSPKRTRFRKQHRGRMKGMSYRGSHICFGRYALQALEPSWITSRQIEAGRRAMTRYARRGGKIWVRIFPDKPVTIRPAETRMGSGKGSPEYWVSVVKPGRILYEMGGVSETVARAAIEIAASKMPIRTQFIIAG
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PDIA1_MACFU
Sequence: MLRRALLCLAVAAAPGLYADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKYNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESDELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEEVAFDENKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAIKVHSFPTLKFFPASVDRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL
What is the function of this protein?
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds.  At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell.  May therefore cause structural modifications of exofacial proteins.  Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins.  At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins.  At low concentrations, facilitates aggregation (anti-chaperone activity).  May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis.  Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.  Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
What are the official names of this protein?
Protein disulfide-isomerase, PDI, Prolyl 4-hydroxylase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. Localizes near CD4-enriched regions on lymphoid cell surfaces. Colocalizes with MTTP in the endoplasmic reticulum.
Protein: MED24_DANRE
Sequence: MKVVNLKQAILQAWKERWSDYQWAINIKKNCPKGATWDYLNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRELCVKSLLEIMDMFSNRLSCHGKAEECIGLCRAMLCTVVWLLQGCAWYCERLRDPNDFSALESSLRACLERMANLLHSTKNRALVHIARLEEQASWTNVEQAVLKLTENLSAVTNPTLKESLEECVSLVKSIPQMLCLQCDPPVHTTFPSVHAFIMLEGTMNLTGETQPLVEQLMMIKRMQRIPAPLFVLEIWKACFTGLIESPEGNEELKWTAFTFLKIPQVLLRLKKYPQGEKTQDFTEDVNVAFEYLLNLTPLLDKADQRCNCDCLSLLLQECNKLGLLSEANTATLTAKRSEDREHAPRLKTAENANIQPNPGLILRAEPTVTNILKTVDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIKLNEFPKHISGEGSKSASVRALLFDISFLMLCHVVQTYGSEVILSDPSPSSETPFFETWLQTCMPEEGKTLNPDHPCFRPESGKVESLVALLNSSSEMKLVQMKWHEICLSTPAAILEVLNAWENGVLSVEAVQKITDNIKGKVCSMAICAVAWLVAHVRMLGLDEREKPQTMIRQLMTPMSGENTLQFYHERVVIMSSILEHMCADVFQQTGLSLRPAVEGQEPIPYRNLLPARLPIRQALQSQFRKVLEKGWVDSHAFHLFENLLHMGGVFWFTNNLVKELLKETRKEWASRVVELLYSIFCLDTQQITLTLLGHILPRLLTDPAHWHSLADPPGRALAKLSVWCALSSYSSHHKGQASARQRKRHREDIEDYTSLFPLDDTQPSKLMRLLSSNEDENSMLSSPGDRSISSSLSASQLHTVNMRDPLNRVLANLFLLISSQLGSKTAGPHTQFVQSFVEECVDCSEQGSRSSILQFMPFTMISELVKLQSLAKPKTVLSITDLSLPLGRRMAAKAIAAL
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).  Required for proliferation of enteric nervous system precursors.  Required for the development of dopaminergic amacrine cells and rod photoreceptor cells in the retina.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 24, Mediator complex subunit 24, Protein lessen, Thyroid hormone receptor-associated protein 4 homolog, Trap100 homolog.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 24 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ERB1_KLULA
Sequence: MARKNSSLNGSESAELVVKKRVLEESELSDSEDERIEVDGLIDEEASENEAEEAEDDDSDAEFNRLLAEEENGQEEEYNTSDFSEEGDAFSITDKLSNVKLTVIPETSDEGIVRTKYSDGRPRILKSEINPVYDSDDSDAEAKNTIGNIPLSAYDEMPHIGYDINGKRIMRPAKGSALDQLLESIELPEGWTGLLDKDSGASLNLTEEELELINKLQNNQQTDESVNPYEPLIDWFTRHESVMPVTAVPEPKRRFVPSKHEAKRVMKIVKAIREGRIIPPKKLKELREKEEQDSHNYDLWGDAEEISEHVMNLRAPKLPPPTNEESYNPPEEYLLTPEEIDAWEKMEPSERERNFVPHKFAALRKVPGYSESVRERFERSLDLYLAPRVRKNKLNIDPESLIPELPSTKDLRPFPIRCSTVYVGHKGKIRTMSIDPTGLWLATGSDDGTVRVWEILTGREVYQVTILNAEENNDDHIDVVEWNPDSTTGILAVTAGENIFLLVPPIFGFEIENTGKSKIEYGFGFDTFGNVKKSNLNVNSDDEDDGAESHAVKKQVAQWNKPTERQAANDICIVITCRKSVKKLSWHRKGDYFVTVQPDSGNTSVLIHQLSKHLTQSPFKKSKGIIMDAKFHPFKPQLLVCSQRYVRIYDLSQQVLIKKLLPGARWLSTIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVSFHKKLPLFCSAADDGNIHVFHATVYDDLMKNPMIVPLKKLTGHKIVNSLGVLDTIWHPREAWLFSAGADKTARLWTT
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein ERB1, Eukaryotic ribosome biogenesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: GLGC_YERPN
Sequence: MVRFESTDSLMLARQLPNKTVALILAGGRGSRLKDLTATRAKPAVHFGGKFRIIDFALSNCLNSGVRRIGVITQYQSHTLVQHIQRGWSFLNEEMNEFVDLLPAQQRLSTEQWYKGTADAVCQNLDIIRRYDAEYIVILAGDHIYKMDYSRMLLDHVEKGAECTVACIPVPISEGSEFGIMEVTADYQITAFYEKPANPPPIPGDPSNALASMGIYIFNADYLFKLLEEDNNTPGSSHDFGKDIIPQLTARKVVWAHPFDLSCVTSNAELPPYWRDVGTLDAYWRANLDLASVTPELDMYDRAWPIRTHMEPLPPAKFVQDRSGSHGMTMNSLVSGGCIVSGSVVVHSVLFPRVRVNSFCTIDSSLLLPDVHVGRSCRLRRCIIDRACHIPEGMVIGENADEDSARFYRSEGGGGVSDSGYAGKVRGKIEPLGFLFVRLDLLIRLSLLIRLNLFIRMNLLIILTLFFKLASIQASH
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: PCKA_PSESM
Sequence: MTQINNAVHTDLSTDELVKEALARNEGVLSDTGALVVETGHRTGRSPVDRFIVEEPSTQDAIAWGPINRKFPAEKFDALWNRVGAYLAERERFVSHVHVGSDPAHYLPVKMTTETAWHNLFGRCLFINPEQYNPAGKDEWEIQNAPWFVCDPERDGTNSDGTVIINFAARKVLIAGMRYAGEMKKAMFSVQNFLLPAVDVLPMHCAANMGEEGDVTLFFGLSGTGKTTLSADESRYLIGDDEHGWGVGVVFNIEGGCYAKCIDLSEKNEPVIWKAIQHGAVLENVVLDPVTKTADYADSSLTQNSRAAYPRELIEKRAPKNLGGEPNAVIFLTCDLTGVLPPVSILSEEQAAYHFLSGYTALVGSTEMGSGSGIKSTFSTCFGAPFFPRPAGEYAELLIKRIRGFKSKVYLVNTGWTGGGYGVGKRFNIPTTRGVIAAIQSGALIGAETEHLDTINLDVPKLVPGVDTGLLNPRNTWADKAAYDEAAKALAGLFVENFKKFDVSDAIKAAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_CHRVO
Sequence: MVKVGIVGGTGYTGVELLRLLAKHPQACVTAVTSRKDAGIRVDEMFPSLRGRIDLAFTTPDEARLAECDVVFFATPNGIAMQDAAALLDAGVRVIDLAADFRIKDVFEWEKWYGMQHASPHLVADAVYGLPEVNREAIRSARLVANPGCYPTAVQLGFLPLIEAGVIDTASLIADCKSGVSGAGRKGEIGALLAEAGDSFKAYGVAGHRHLPEIRQGLARASGKPVGLTFVPHLTPMIRGIHATLYARLTKDVDLQRLFESRYADESFVDVLPAGSHPETRSVRGANLCRIAVHRPQGGDTVVVLSVIDNLVKGAAGQAVQNLNLMFGLPENEGLDVVPLLP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLF7_HUMAN
Sequence: MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEAAICEKSSAVDILLSRDKLLSETCLSLQPASSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALSSVKVGGVATAAAAVTAAGAVKSGQSDSDQGGLGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI
What is the function of this protein?
Transcriptional factor (PubMed:9774444, PubMed:16339272).  Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity).  Represses the corneal epithelium differentiation (PubMed:28916725).  Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272).  Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).
What are the official names of this protein?
Krueppel-like factor 7, Ubiquitous krueppel-like factor.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TIG_MYCSJ
Sequence: MKSTVEKLSPTRVRINVEVPFTELEPDFDRAFKELAKQVRLPGFRPGKAPRKLLEARVGREAMLDQVVGEAVPGRYTEAVTSSDVQPLGQPEIEITKKEYGEDLVFTAEVDVRPEITLPDLSALEITVDPIEITDEEVDTELQSLRARFGTLTGVDRPAKDGDFVSIDLSATVDGKDVPEATTEGLSHEVGSGQLIEGLDDAIVGLSEGESKEFTTTLAAGEHAGKEAVVTVTVKSIKERELPEPDDEFAQLASEFDTIDELKESLTEQVRRVKRVQQAEQIRDKALELLLEQTEVPLPEKIVQAQIDDTVHNAIHGLDHDEDRFAEQLAEQGSSREEFDANTRTEAEKAVKTQLLMDALADQLEVQVGQGDLTERLVLMSRQYGLEPQQLLQILQQNNQLPAMFADVRRGLTIAAVVHGATVKDTDGNDIDTTEFFGPSGGAQAEAEGADEADADSDADSDTEADSDADSDTEADEADEAK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: KUP1_RHOPB
Sequence: MSQNTKGAGLLISAIGVVYGDIGTSPLYALKETFAGHHPIAVTPDNVFGVLSLVFWTVMLLVTVKYVIVIMRADNHGEGGSLALLALVTELTRGYRVYYPLMLLGVIAAALFYGDSMITPAISVLSAVEGLEVVTPRLTPYVVPITAVVLTGLFMIQKRGTGLVGKLFGPVMCLWFLVLALLGIVNIVAAPHVLGAINPIYAADFIVKHPMMSFFALGSIVLAVTGGEALYTDMGHFGRFPIRVAWFALVLPALLLNYFGQGALLLSDPSAIQNPFFRQVPEWMVVPMVGLATCATVIASQAVISGAYSVARQAIQLGLLPRMTIVHTSGEEEGQIYIPFTNWTLYIAVMALVIGFQSSSNLAAAYGIAVTGTMMIDTILVAFVMALMWRWHWIAVAAVAGTLLLVDLAFFFANIIKVAQGGWFPLFIGVLSFTVLTTWRRGRELVRNQVKKLAVPLDVVMRALGPNVSRARGTAVFLTAATDGVPPALLHNLKHNQTVHQRVVLATVMTADTPYVPDSERVTMTDLGDGFHRLIIRYGFMQTPDVPAALELCKAFGQEFNMMATSFFLSRETYVPSLNPGMAHWRERLFTFMTLNATRATIFFKIPTDRVVELGTQLEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup 1.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RM43_BOVIN
Sequence: MTARGTASRFLTSVLHNGLGRYVQQLQRLSFSLSRDAPSSRGAREFVEREVTDFARRNPGVVIYVNPRPCCVPRVVAEYLNGAVREESLNCKSVEEIATLVQKLADQSGLDVIRIRKPFHTDSPSIQGQWHPFTNKPTALGGLRPREVQNPAPTQRPAQ
What are the official names of this protein?
39S ribosomal protein L43, mitochondrial, L43mt, MRP-L43, Retina-specific 15.7 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL43 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PDXT_RHOOB
Sequence: MTRPLVGVLALQGDVREHLAALNDSGADAVGIRRPEELEKIDGLVIPGGESTTMSKLLQIFELLEPLKARLRDGLPAYGSCAGMILLASEILDTRPDAQHLGAIDMTVRRNAFGRQVDSFESDLEFEGIVGDPMRAVFIRAPWVERVGDDVQILARVPESGGAAAGRIVAVRQGSVVATSFHPEVTGDRRVHELFVDIVRGV
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: PK21A_RHIME
Sequence: MALDEAPAEARPGSRAVELEIDGRSRIFDIDDPDLPKWIDEEAFRSDDYPYKKKLDREEYEETLTKLQIELVKVQFWMQATGKRVMAVFEGRDAAGKGGAIHATTANMNPRSARVVALTKPTETERGQWYFQRYVATFPTAGEFVLFDRSWYNRAGVEPVMGFCTPDQYEQFLKEAPRFEEMIANEGIHLFKFWINIGREMQLKRFHDRRHDPLKIWKLSPMDIAALSKWDDYTGKRDRMLKETHTEHGPWAVIRGNDKRRSRINVIRHMLTKLDYDGKDEAAIGEVDEKILGSGPGFLR
What is the function of this protein?
Uses inorganic polyphosphate (polyP) as a donor to convert ADP to ATP.  Can also convert GDP to GTP, with lower efficiency.  Cannot dephosphorylate ATP in the presence of polyP.
What are the official names of this protein?
ADP-polyphosphate phosphotransferase 1, Polyphosphate kinase PPK2 1.
What is the protein family that this protein belongs to?
Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
Protein: RL14_POLAQ
Sequence: MIQTESRLQVADNTGASEVLCIKVLGGSKRRYASIGDVIKVSVKSAAPRGRVKKGDIYNAVVVRTAKGVRRPDGSLIKFDANAAVLLNAKLEPIGTRIFGPVTRELRTEKFMKIVSLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RT12_ARATH
Sequence: MPTFNQLIRHGREEKRRTDRTRALDKCPQKTGVCLRVSTRTPKKPNSALRKIAKVRLSNRHDIFAYIPGEGHNLQEHSTVLIRGGRVKDLPGVKFHCIRGVKDLMGIPGRRRGRSKYGAEKPKSI
What is the function of this protein?
Protein S12 is involved in the translation initiation step.
What are the official names of this protein?
Ribosomal protein S12, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TUSD_PHOLL
Sequence: MSSLSYCLLVTGPAYGTQQASSAYQFAQALITMGHKLNTVFFYREGVYNGNQLTSPASDEFDLVSAWQMMATEHRFSMHICIAAALRRGVIDAQQASELNLPVANLAEGFELSGLGTLAEAMLICDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URED_PARDP
Sequence: MRGRRLSGPMFDAIAPIRMQRSRGAASVRLGPRGIEDLAQSGSAKAMLPRMTAGRPEIVFLNTAGGLASGDRLDYRIELAPRTQALATTQTAERAYRAKDAPAQIRLHLQVGEGGWLDWLPQETILYDGARLGRETAVDLAPGAGCLLLEPIILGRLAMGETIRHLQLTDRRIVRQDGRMIHHDALALDDAALSRLHHPAMLGKARAMASLALIAPHAADLLEPARAVLDEPGVTGAASAPPGRLILRLLADDGWPLRRQVIRLLRVLRPDPLPRIWQV
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.