PharMolix/UniProtQA huggingface dataset:
Protein: PYRH_CHRSD
Sequence: MSAPTDRSATPAERNEKSKYKRILLKLSGEALIGEHEFGIDPKVLDRMALEIGQLVGIGVQVGIVIGGGNLFRGAALHAAGMERVTGDHMGMLATVMNGLAMRDALERSNIRSRVMSAIPMSGVVEHYDRRTAIRYLTSGDVVIFSAGTGNPFFTTDSAACLRGIEIDANVVLKATKVDGVYDKDPVKHADAAKYERLTYDDVLDQKLGVMDLTAICLVRDHDMPVRVFDMTKPGALLNLVVGGKEGTLVDRG
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCD_CHESB
Sequence: MNWITNYVRPKINSMLGRREMPENLWIKDPESGEMVFHKDLEENQWVVPASGYHIKISAKDRLKHFFDNGAYETLENPKAGVDPLKFRDERRYIDRLRDAKAKTNLDDAVVNAIGRIEGLEILATVQDFAFMGGSLGMAAGEAIVRGFETAVERRLPLVLFAASGGARMQEGILSLMQLPRTTVAVDRLKEAGLPYIVVLTNPTTGGVTASYAMLGDVHIAEPGALIGFAGPRVIEQTIREKLPEGFQRAEYLKEHGMVDMVVSRLEMKATIARLLKILLKEQATEENGSRRLPAPEAAVVEAAVNA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_PSEE4
Sequence: MSGLFITLEGPEGAGKSTNREYLAARLREQGVDVVMTREPGGTPLAERIRELLLAPSEEAMAVDTELLLMFAARAQHLAQVIRPALARGAVVLCDRFTDATYAYQGGGRGLSVERIAILESFVQGELRPDLTLVFDLPVEVGLARAAARGRLDRFEQEGQAFFEAVRQAYLQRAGQQPQRYSLLDAAQPLAAVQRAIDALLPGILERCRG
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: NAPA_SALDC
Sequence: MKLSRRSFMKANAVAAAAAAAGLSVPGVARAVVGQQEAIKWDKAPCRFCGTGCGVLVGTQQGRVVACQGDPDAPVNRGLNCIKGYFLPKIMYGKDRLTQPMLRMKDGSYHKDGEFTPVSWEQAFDVMEEKFKTSLKEKGPEAIGMFGSGQWTIWEGYAAAKLFKAGFRSNNIDPNARHCMASAVVGFMRTFGMDEPMGCYDDIEQADAFVLWGSNMAEMHPILWSRITNRRLSDPNVKVAVLSTFQHRSFELADNGIVFTPQSDLVILNYIANYIIQNNAVNQDFFTKHVNLRKGATDIGYGLRPTHPLEKAAKNPGSDASEPMSFDEYKAFVAEYTLDKTAEMTGVPKDQLEQLAQLYADPNKRVISYWTMGFNQHTRGVWANNLVYNLHLLTGKISQPGCGPFSLTGQPSACGTAREVGTFSHRLPADMVVTNEKHRDICEKHWQIPAGTIPAKVGLHAVAQDRALKDGKLNVYWVMCNNNMQAGPNINEDRMPGWRDPRNFIIVSDPYPTVSALSADLILPTAMWVEKEGAYGNAERRTQFWRQQIKAPGEAKSDLWQLVQFSRRFKTEEVWPEALLSQKPELRGKTLYDVLFATPAVSKFPLSELKEDQLNDESRELGFYLQKGLFEEYAWFGRGHGHDLAPFDDYHNARGLRWPVVEGKETQWRYSEGNDPYVKAGEGYKFYGKPDGKAVIFALPFEPAAESPDNEYDLWLSTGRVLEHWHTGSMTRRVPELHRAFPEAVVFIHPLDAKARDLRRGDKVKVSSRRGEVISIVETRGRNRPPQGLVYMPFFDAAQLVNNLTLDATDPLSKETDFKKCAVKLAKV
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: RK5_CHLRE
Sequence: MTQRLKNLYTKTIVPKLTTNFNYSNMHEVPKIEKIVINRGIGDASQNQKIVESSLKELAMIAGQKGVVTRSKKAIAGFKLRQQMPVGVTVTLRGDRMYGFLDRLIHLALPRVRDFQGISSKSFDKKGNYSLGLEEQLMFPEIEYDKIDQVRGMDISIVTTAKTQEEGLALLKEFGLPFK
What is the function of this protein?
Binds 5S rRNA, forms part of the central protuberance of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L5, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TMCAL_OENOB
Sequence: MEATGLITEYNPFHNGHLYHLKKAQELTKADVTIVLMSGNWVQRGLPAITDKWKRAQAAIDAGADLVFELPFYYAVQAGEIFAQGAVRLLSDLQVSSIICGSEHADIDFINLAAHEPDISGNSNFDKKNRTFASNYAAALEEKTGFYLENANDILAFSYAKAILNQNLTEKIKLRTISRVSADYHDQFLNDGEIASATAIRKALSEGQNVDSYTPMSDLQYTDYEARLFQLLKYRLSTDGLGQIRSIYQVNEGMEYLIKQAIEKNPSDFGELLALIKSKRYTFARLHRVLVYILLNIKVDQMNLAMQNPYHRLLGFTEKGRQYLHEKKGRFNFPTISHVDQKTANKSLAIDYKAGLVYNQIMDYKSTQDIKRTPIQS
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_MAGMM
Sequence: MAEHKSDFSTDLKKGDTVIVVAGKDKGKQGQILQVLGKKSSVLVEKVNMIKRHTKPAQNREGGIVEKEAPIHISNVMIVDPATGKATRIKKKNLEDGRKVRVAAGSGEVLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: LGT_CLOK1
Sequence: MDPIAFSIGGFQIRWYGIMIALGVLAALILANLNCRYKGYNFDSLIDVFLISFPLAIIGARVYYVVFQFQDYRNNLMDIFNIRLGGLAIHGGIIFGLGAAYIVSRYKKMDFIKLWDCFAPSIILGQAIGRWGNFFNGEAHGGIVGYEFISKFPLFIQRGMYINGDYYNPTFLYESLWDLIVCIILVYIFRKKHKRGTVICTYVGLYSLGRFFIEGLRTDSLMIGHIRVAQLVSFIGIVLSISFFVYLKGRGKRVD
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLNB2_METTM
Sequence: MKEVIAIIRPKNMKKTRDVLESLGFPSFNATRVLGRGKQRAIIDEVTIPSPSPEIDEVRGTMRYIPKRMIQITVEDPDVQLVVEAIMKVNHTGKIGDGKIFVCPVDDAMRIRTGDRGTEAL
What is the function of this protein?
Could be involved in the regulation of nitrogen fixation.
What are the official names of this protein?
Nitrogen fixation nifHD region GlnB-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the P(II) protein family.
Protein: PUR2_PHEZH
Sequence: MNILLVGSGGREHALAWKIAASPLVKRLVAAPGNPGMAEQCELRAVGPTDVPALVALAKEIAADLVVIGPESSVDAGLADQLQAEGIPCFGPTAGAGQLESSKAFTKAFADRYGLPTAAYRVCESAEAARAALELFEPPYVIKADGLAAGKGVTVAQDRGEAEAAIDDAFGGRFGAAGARVVVEEFLEGEIGSLFALCDGEASMLFGWAQDHKRVFDGEQGPNTGGMGTYSPAPVFTPELVEQVRTRLVEPAFAGIAADGSPYRGVLFVELMATKHGPKLVEFNVRFGDPECQVLMLRLESDLVPYLVACANGTLGDMPPPVWRDEAAVCVVIAAKGYPGTPAAGGEIRGLDQDLGDDVVVFHAGTKRDADGTLRAAGGRVLNVCARGADLRTARDRAYAAIERIEFADGFCRSDIGWRALGR
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: ENDA_SULTO
Sequence: MIGELVKDKILIKNIEDARLIYKMGYYGKPIGISKPKSAEEINSELILSLIEGVYLVKKGKLEIVSNGERLDFERLYQIGVTQIPRFRILYSVYEDLREKGYVVRSGIKYGADFAVYTIGPGIEHAPYLVIALDENSQISSNEILGFGRVSHSTRKELILGIVNLTNGKIRYIMFKWLKM
What is the function of this protein?
Endonuclease that removes tRNA introns.  Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini.  Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
What are the official names of this protein?
tRNA-splicing endonuclease, tRNA-intron endonuclease.
What is the protein family that this protein belongs to?
Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
Protein: ITPK1_HUMAN
Sequence: MQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKASSQ
What is the function of this protein?
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 (PubMed:11042108, PubMed:8662638).  Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 (PubMed:11042108).  This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not.  Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:11042108, PubMed:8662638).  Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4 (PubMed:17616525, PubMed:11909533).  May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium (PubMed:11909533).  Probably acts as the rate-limiting enzyme of the InsP6 pathway.  Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525).  Plays an important role in MLKL-mediated necroptosis.  Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation.  Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525).
What are the official names of this protein?
Inositol-tetrakisphosphate 1-kinase, Inositol 1,3,4-trisphosphate 5/6-kinase, Inositol-triphosphate 5/6-kinase, Ins(1,3,4)P(3) 5/6-kinase.
What is the protein family that this protein belongs to?
Belongs to the ITPK1 family.
Protein: CH60_PHOV8
Sequence: MAKDIKFNIDARDELKKGVDELANAVKVTLGPKGRNVIIEKKFGAPHITKDGVTVAKEVELADAFQNTGAQLVKSVASKTGDDAGDGTTTATVLAQSIVGVGLKNVTAGANPMDLKRGIDKAVAKVVESIKSQAEMVGDNYDKIEQVAAVSANNDPTIGKLIADAMRKVSKDGVITIEEAKGTDTTIGVVEGMQFDRGYLSAYFVTDTEKMECVMEHPYILIYDKKISNLKDFLPILEPAVQSGRPLLVIAEDVDSEALTTLVVNRLRSQLKICAVKAPGFGDRRKAMLEDIAVLTGGIVISEEKGLKLEQATLEMLGTCDKVTVSKDNTTIVNGAGAKENIQERINQIKAEIKNTTSDYDKEKLQERLAKLSGGVAVLYVGAASEVEMKEKKDRVDDALCATRAAIEEGIVPGGGVAYIRASEALEGLKGDNEDETTGIEIIKRAIEEPLRQIVANAGKEGAVVVQKVREGKGDFGYNARTDVYENLHAAGVVDPAKVTRVALENAASIAGMFLTTECVIVEKKEDKPEMPMGAPGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSP_ICMV
Sequence: MRRGAYTPRSTPFPRDRRSYNAGKGRSFRSYRRRGPVRPLARRNLFGDDHARAFTYKTLSEDQFGPDFTIHNNNYKSSYISMPVKTRALSDNRVGDYIKLVNISFTGTVCIKNSQMESDGSPMLGLHGLFTCVLVRDKTPRIYSATEPLIPFPQLFGSINASYADLSIQDPYKDRFTVIRQVSYPVNTEKGDHMCRFKGTRRFGGRYPIWTSFKDDGGSGDSSGLYSNTYKNAILVYYVWLSDVSSQLEMYCKYVTRYIG
What is the function of this protein?
Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus.  Begomoviruses use 2 proteins to transport their DNA from cell to cell.  The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall (By similarity).
What are the official names of this protein?
Nuclear shuttle protein, NSP, Protein BR1, Protein BV1.
What is the protein family that this protein belongs to?
Belongs to the begomovirus nuclear shuttle protein family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocated to the plasma membrane by the movement protein BC1.
Protein: CLPP3_SYNP6
Sequence: MFSSHASLPIHSRRLAAGLDSRWQQPQIQAIAGSQAIVPTVVEQSGRGERAFDIYSRLLRERIVFLGTGVDDAVADSIVAQLLFLEAEDPEKDIQLYINSPGGSVTAGMAIYDTMQQVAPDVATICFGLAASMGAFLLSGGAQGKRMALPSARIMIHQPLGGAQGQAVDIEIQAREILYHKSTLNDLLAQHTGQPLEKIEVDTDRDFFMSPEEAKAYGLIDQVLTRPTMAITDHNDAVLQ
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 3, Endopeptidase Clp 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H18A1_CYRHA
Sequence: MKLSIIIIATSLVIAVVAFPSKDSKAIENDKTEQRMEIVVQETARACSKQIGDKCKRNCECCGKTVVCGTIYVGGKEVNQCMDKTSDNAILNGLGKGMNFIENTFSFCV
What is the function of this protein?
Putative ion channel inhibitor.
What are the official names of this protein?
Hainantoxin-XVIII, HNTX-XVIII, Peptide F7-35.67.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 25 family. F7 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NA131_ACTEQ
Sequence: MNRLMILVFAAVFLALASADEDVDIAKRGIPCLCVSDGPSTRGNNLSGIMWMKTGGYGGNGCPKGWHFCGKSRGFFSDCCKR
What is the function of this protein?
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction.  Causes death to crabs.
What are the official names of this protein?
Delta-actitoxin-Aeq2c, Delta-AITX-Aeq2c, Ae3-1, Neurotoxin 3-1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: KIP1_YEAST
Sequence: MARSSLPNRRTAQFEANKRRTIAHAPSPSLSNGMHTLTPPTCNNGAATSDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLVDLFKELSSLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQDSKDHGQNKNFVKIGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVDHSNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSKDTCLKDYIQEIEKLRNDLKNSRNKQGIFITQDQLDLYESNSILIDEQNLKIHNLREQIKKFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVIQQRDFSLENSQKQYNTNQNMQLKISQQVLQTLNTLQGSLNNYNSKCSEVIKGVTEELTRNVNTHKAKHDSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDSTSHYRKDLNEIYQSHQQFLKNLQNDIKSCLDSIGSSILTSINEISQNCTTNLNSMNVLIENQQSGSSKLIKEQDLEIKKLKNDLINERRISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAENTLKTVSQNNESFTNDLISLSRGMNMDISSKLRSLPINEFLNKISQTICETCGDDNTIASNPVLTSIKKFQNIICSDIALTNEKIMSLIDEIQSQIETISNENNINLIAINENFNSLCNFILTDYDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEASVIKALPLLDYPKQFQIYRDAENKSKDDTSNSRTCIPNLSTNENFPLSQFSPKTPVPVPDQPLPKVLIPKSINSAKSNRSKTLPNTEGTGRESQNNLKRRFTTEPILKGEETENNDILQNKKLHQ
What is the function of this protein?
Required for assembly of the mitotic spindle.  Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles.  Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together.  This force seems to be mediate by KAR3.
What are the official names of this protein?
Kinesin-like protein KIP1, Chromosome instability protein 9.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Note=Spindle microtubules that lie between the poles.
Protein: ICME_ARATH
Sequence: MHSPLQTQQPEQRCWPMTSTVSEIEEVLPDEDSDRTTLLNGEPLRRRVSGKSPVDEGPRRIFRQQSFGRDIGHAAAETYLITGLSFKLLRYLGVGYRWMTKLLALTCYAMLLMPGFLQVAYSYFFSKQVRRSIVYGDQPRNRLDLYLPSNNDGLKPVVVFVTGGAWIIGYKAWGSLLGMQLAERDIIVACLDYRNFPQGTISDMVTDASQGISFVCNNISAFGGDPNRIYLMGQSAGAHIAACALLEQATKELKGESISWTVSQIKAYFGLSGGYNLYKLVDHFHNRGLYRSIFLSIMEGEESFEKFSPEVRLKDPVVGKAASLLPPIILFHGSSDYSIPCDESKTFTDALQAVGAKAELVLYSGKTHTDLFLQDPLRGGKDELFDDIVSVIHAEDNDGLTKDSLAPPRKRLVPELLLKLAREISPF
What is the function of this protein?
Catalyzes the demethylation of isoprenylcysteine methylesters.  In vitro, is specific for N-acetyl-S-farnesyl-L-cysteine methyl ester (AFCme) and has low activity toward N-acetyl-S-geranyl-L-cysteine methyl ester (AGCme).  Acts as a positive regulator of ABA signaling.  May be involved in the demethylation and inactivation of isoprenylated negative regulators of abscisic acid (ABA) signaling.  Carboxyl methylation is a reversible and potentially regulated step in the post-translational modification of prenylated proteins.
What are the official names of this protein?
Isoprenylcysteine alpha-carbonyl methylesterase ICME, Isoprenylcysteine methylesterase, Prenylcysteine methylesterase, AtPCME.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Isoprenylcysteine methylesterase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: ILVD_LACE2
Sequence: MISDNARSGMQQAPARSLFNALGFTAEEMKKPMIGIVSSYNEIVPGHMNIDKIVNAVKLGVAEAGGVPVVFPAIAVCDGIAMGHVGMKYSLVTRDLIADSTECMAIAHQFDGLVMVPNCDKNVPGLLMAAARLNLPTVFVSGGPMLAGHVKGKKRSLSSMFEAVGSYAAGTMTEEDVLEFEEKVCPTCGSCSGMYTANSMNCLTEALGMGLRGNGTIPAVYSERIKLAKHAGMAVMDMVNKGITARDIITKDSIMNALTVDMALGCSTNSMLHLPAIAHEIGFDFDIKFANPISEKTPNLCHLAPAGPTYMEDLNEAGGVYAVMKELADIGLLNTDCLTVSGKTIGECIATAYNRDPEVIRTVDNAYSKTGGLAVLSGNLAPDGSVVKRSAVVPEMLVHEGPARVFDSEEDAIAAIKGGKIVEGDVVVIRYEGPKGGPGMREMLNPTSAIAGMGLGSSVALITDGRFSGASRGASIGHVSPEAAVGGPIALVEEGDIISIDIPGLKLELKVSDEELAARKAKWQPREPKVTTGYLKRYASLVTSGNRGAILKSSADE
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: TR134_MOUSE
Sequence: MSFSHSFIFIVIFCMQSLAALLQNGFMATVLGREWVRSQGLPAGDMIMACLAASRFCLHGIAVLNNFLASAMFWTIKNYFSILWDFTNTVNFWFTTWLAIFYCVKISSFSHPIFFWIKWRISRSVPRLLLGSLIIGGLSAISSATGNTIALQMAACENYTIYYKMMAFYLYYFRCHAMLMWVIPFFLFLLSIILLMFSLYRHLEQMRYHRPRTHDYSTQAHIMALKSLAFFLIFYTSYTLLLTVSVAHVINVHGSWHWAWEVVTYMGISLHSTILILSNTKMRKALKIKFPDLCIPRS
What is the function of this protein?
Putative taste receptor which may play a role in the perception of bitterness.
What are the official names of this protein?
Taste receptor type 2 member 134, T2R134, Taste receptor type 2 member 34, T2R34.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNAK_HELMI
Sequence: MGKIIGIDLGTTNSCVAVLEGGESVVIPNKEGARTTPSVVGFSKTGERLVGQVAKRQAITNPDRTVISIKRHMGTDYKVKIDDKNYTPQEISAMILQKLKADAEAYLGEPVTQAVITVPAYFTDSQRQATKDAGAIAGLEVMRIINEPTAAALAYGIDKGEDQTILVYDLGGGTFDVSILELGDGLFEVKATSGNNRLGGDDFDEKIINWMIAEFKKETGVDLRGDKMAMQRLKEAAEKAKIELSGVMSTNINLPFITATADGPQHLDMTLTRAKFDELTADLVEMTMGPTRQALQDAKLEPKDIDKVILVGGSSRIPAVQEAIRKYLGKEPFKGINPDEVVAMGAAIQAGVLGGEVKGIVLADVTPLSLGIETLGGICTVLIPRNTTIPTSKSETFTTAADNQTSVEVHVLQGERKLASQNKTLGRFHLSGIAPAPRGIPQIEVKFDIDANGIVHVSAKDKATGNEQKITITASTGLSKEEIERMIKDAELHAEEDRKRQEEVEIRNQADSMVYQAEKTLKDLGDKAEAADKAKIESAKEELKKALEGTDMEEIKKKTEALTTVVYELSTKLYQQASAPGAGPEGASGGFGGENKKDDNVVDADYTVIDDDKKKT
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: S6A17_BOVIN
Sequence: NVWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWHYVCPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSECPVSRNGTVAVVEAECEKSSATTYFWYREALDISNSISESGGLNWKMTLCLLVAWRIVGMAVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAIDGILHMFTPKLDKMLDPQVWRDAATQIF
What is the function of this protein?
Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine.  In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).
What are the official names of this protein?
Sodium-dependent neutral amino acid transporter SLC6A17, Sodium-dependent neurotransmitter transporter NTT4, Solute carrier family 6 member 17.
What is the protein family that this protein belongs to?
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A17 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Postsynapse. Presynapse. Note=Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals.
Protein: Y1063_METPE
Sequence: MRLTWPGHACVLLEGSQRVLIDPYVLNGTIPKDPDLVVLTHGHFDHFGETLTLDAPTVAVNDLAKALSALGMQATGLNFGGSITINGVTVSLTPAVHSVSMLELDGTKIMCGEAAGVVIRMDGVTVYHAGDTALFSDMRLIGELYHPDVALLPIGGRFTMDSAAAMMAAAYIGAPMVIPIHYNTWPAIEQDADAFKEAIERTTDMQVMVLPSGGSIEI
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Mpal_1063.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: LCL2_CANGA
Sequence: MNLLMVLFVAQAHAFFFGQQQQQQQQQASYEDRVLDSGCAKYLCSDTLECVDSWKDCPCPFPKSQLKCMLPKGSNRPYVCISKPATHDEKLNLIYDDPVQGPKAAIKGMRDCGWVQQNL
What is the function of this protein?
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
What are the official names of this protein?
Long chronological lifespan protein 2.
What is the protein family that this protein belongs to?
Belongs to the LCL2 family.