PharMolix/UniProtQA huggingface dataset:
Protein: METXS_PSEF5
Sequence: MPTAFPPDSVGLVTPQIAHFSEPLALACGRALPAYDLIYETYGQLNASASNAVLICHALSGHHHAAGYHSVDDRKPGWWDSCIGPGKPIDTNRFFVVSLNNLGGCNGSTGPSSLNPDTGKPFGADFPVLTVEDWVHSQARLADRLGISQWAAVIGGSLGGMQALQWTITYPDRVRHCLAIASAPKLSAQNIAFNEVARQAILTDPEFHGGSFQEQGVIPKRGLMLARMVGHITYLSDDSMGEKFGRGLKSEKLNYDFHSVEFQVESYLRYQGEEFSGRFDANTYLLMTKALDYFDPAANCDDDLAKTFAHATAKFCVMSFTTDWRFSPARSRELVDALMAARKDVCYLEIDAPQGHDAFLIPIPRYLQAFSHYMNRITL
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFB1M_DROME
Sequence: MAQPSARVLQSGMRLPPMPTIRELVKLYRLQARKQLSQNFLMDERLTDKIVKSAGRIDPRDLVLEVGPGPGGITRSILRRHPQRLLLVEKDPRFGETLQLLKECASPLNIQFDIHYDDILRFNIEQHIPDTSQRIHLIGNLPFAISTRLLINWLDDLAARRGAFRRIDTCMTLTFQQEVAERICAPVGGEQRCRLSVMSQVWTEPVMKFTIPGKAFVPKPQVDVGVVKLIPLKRPKTQLPFHLVERVVRHIFSMRQKYCRRGYGTLLPPEDREEVAEKLFQRAEVQDTLRPFELTVEQCLRLAEVYSEHLVTRPEVAAYDYRAPKNVEVL
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop.  In contrast to mtTFB2, it does not have a critical role in either transcription or regulation of the copy number of mitochondrial DNA.
What are the official names of this protein?
Dimethyladenosine transferase 1, mitochondrial, Mitochondrial 12S rRNA dimethylase 1, Mitochondrial transcription factor B1, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1, d-mtTFB1.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AROQ_HELP2
Sequence: MKILVIQGPNLNMLGHRDPRLYGMVTLDQIHEIMQTFVKQGNLDVELEFFQTNFEGEIIDKIQESVGSDYEGIIINPGAFSHTSIAIADAIMLAGKPVIEVHLTNIQAREEFRKNSYTGAACGGVIMGFGPLGYNMALMAMVNILAEMKAFQEAQKNNPNNPINNQK
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: NUSB_HELAH
Sequence: MATRTQARGAVIELLYAFESGNEEIKKIAPSMLEEKKIKNNQLAFALSLFNGVLEKINEIDALIEPHLKDWDFKRLGSMEKAILRLGAYEIGFTPTQNPIIINECIELGKLYAEPNTPKFLNAILDSLSKKLAQKPLT
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PEPQ_PSEA6
Sequence: MQQLAELYPQHISELQSRTKEALSREGIDGLIIHSGQAKRMFLDDNNYPFKCNPQFKAWLPVIDNPNCWLIVNGSDKPKLIFYRPKDFWHKVPPEPNDFWVEQFDVVLLTQADAVEKHLPYDRSRFAYIGEYIEVAKALGFDLVNPDRVLNYLHYQRAYKTDYELVCMRQANALAVAGHNAAAAAFKAGKSEFDINQAYLAAVRQSDNQVPYNNIVALNENSAILHYMEQDVVAPSESRSFLIDAGASFHGYAADITRTYCNGSIPNSSHFAELINGMHQVTLSLADSLKPGVPYSDIHIAAHAQVAQLLHQFDIVNLSPDDILAEQIVSTFFPHGIGHFLGLQVHDVAGHVADDRGTPNPPPAEHPFLRTTRMIEARQVFTIEPGLYFIDSLLADLKSTEKSKFINWDVVDTFRPFGGIRIEDNIIVHRDKNENMTRDLGLN
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: RL7_YERE8
Sequence: MSTITKDQILEGVAALSVMEIVELISAMEEKFGVSAAAVAAGPAAAAEAVEEQTEFNVVLASFGDNKVAVIKAVRGATGLGLKEAKDLVESAPAVLKEGVNKDEAESLKKSLEEAGAAVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RNAS6_SAISC
Sequence: MVLCFPLLLLLLVLWGQVCPLHAIPKHLTKARWFEIQHIRPSPLQCNRAMNGINNYTQHCKPQNTFLHDSFQNVAAVCDLLSITCKNGYHNCHQSLKPVNMTDCRLTSGSYPQCRYSTAAQYKLFIIACEPPQKSDPPYNLVPVHLDSIL
What is the function of this protein?
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine.  Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P. aeruginosa, A. baumanii, M. luteus, S. aureus, E. faecalis, E. faecium, S. saprophyticus and E. coli.  Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria.  Probably contributes to urinary tract sterility.  Bactericidal activity is independent of RNase activity.
What are the official names of this protein?
Ribonuclease K6, RNase K6.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Lysosome. Cytoplasmic granule.
Protein: RL28_ERYLH
Sequence: MSRICELTGKGRQVGHNVSHANNKTKRVFLPNLQNVTLLSEKLDRGFKFRVSTQGLRSVEHNGGLDNWLLKTKDDKLSSNALKVKRELKKAMNEADAAA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: PLSX_ECO45
Sequence: MTRLTLALDVMGGDFGPSVTVPAALQALNSNSQLTLLLVGNPDAITPLLAKADFEQRSRLQIIPAQSVIASDARPSQAIRASRGSSMRVALELVKEGRAQACVSAGNTGALMGLAKLLLKPLEGIERPALVTVLPHQQKGKTVVLDLGANVDCDSTMLVQFAIMGSVLAEEVVEIPNPRVALLNIGEEEVKGLDSIRDASAVLKTIPSINYIGYLEANELLTGKTDVLVCDGFTGNVTLKTMEGVVRMFLSLLKSQGEGKKRSWWLLLLKRWLQKSLTRRFSHLNPDQYNGACLLGLRGTVIKSHGAANQRAFAVAIEQAVQAVQRQVPQRIAARLESVYPAGFELLDGGKSGTLR
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RBL_NEUTE
Sequence: MSPQTETKASVGFKAGVKDYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEEDQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPTYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAMYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHVHAGTVVGKLEGEREITLGFVDLLRDDFIEKDRSRGVFFTQDWVSMPGVIPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAAANRVALEACVQARNEGRDLAREGNEIIKAACKWSPELAAACEVWKAIKFEFAPVDTVDKV
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TYRP_ASPTN
Sequence: MGFYRNLVLVAASCTQALGLCPAPRCDSPDIRHEWGELSREDRLSYISAVQCMKDRPPELSVEEVPAVRSRYDDFTAVHINYTLQIHNSGIFLPWHRHFIWLWEKALREECGFTGTLPYWDWVMWPNLAASPLFDGTETSLSGDGEFNATEQPTELNPEPGLTITIPRGAGGGCVRTGPFKDWVINMGPFAFNESYEPALPDHAFDYNPRCLVRSLNDWVIQTYNNQTVVDTLLDSPDIVEFQNIMGGFPNPPIPIGPHAMGHRSLGPDMLDFFASPQDPAFWQHHGMVDRLWTVWQDADEPWRRFALNGSSTTWYKDDTPEVTLQTTVEFGILDEPRPLYELMSPTAGPYCYTYT
What is the function of this protein?
Tyrosinase; part of the gene cluster that mediates the biosynthesis of Asp-melanin, a pigment that confers resistance against UV light and hampers phagocytosis by soil amoeba (PubMed:28791090, PubMed:27133313, PubMed:29270299).  The nonribosomal peptide synthase melA converts 4-hydroxyphenylpyruvate (4-HPPA) to aspulvinone E (PubMed:27133313, PubMed:29270299).  The tyrosinase tyrP then performs hydroxylations of both aromatic moieties of aspulvinone E (PubMed:27133313).  The product of tyrP is highly unstable, and, due to the high reactivity of methides and ortho-diquinones, the polymeric Asp-melanin forms spontaneously (PubMed:27133313).
What are the official names of this protein?
Tyrosinase P, Melanin biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Golgi apparatus lumen. Note=The oxidizing environment of Golgi or endoplasmic reticulum (ER) is required for tyrP to be active.
Protein: GRPE_LACDB
Sequence: MSKEEFPSEKDLPQEDQEKQAKAAEADKAGVKDDKKVKDDKEEAAKPADVELDQLKAEVAALTQKNKDLEDKYLRSQAEIQNAQRRYSKERADLVKYESQRLGKDILSSVDNLERALQVKADDEASRQLKKGIEMTLEGLVRALKDNGIEEIKADGEKFDPTLHQAVQSVPAENDDQKGHVVQVLQKGYVYKDRTLRPAMVVVAQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADD_PSEAB
Sequence: MGKRIGLFGGTFDPVHIGHMRSAVEMAEQFALDELRLLPNARPPHRETPQVSAAQRLAMVERAVAGVERLTVDPRELQRDKPSYTIDTLESVRAELAADDQLFMLIGWDAFCGLPTWHRWEALLDHCHIVVLQRPDADSEPPESLRDLLAARSVADPQALKGPGGQITFVWQTPLAVSATQIRALLGAGRSVRFLVPDAVLNYIEAHHLYRAPH
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: Y207_METJA
Sequence: MVLYKIRRSKNDPCPSIPSAVIIGYSVGLKLITGHGAQSLSNMAGSYAGKELGIYAMNNGYEFKDIKDIERFLNQLDFAKIEMNEEEDEIIVKISKCNLCPKRICGYEFEGTACPWGGLLIGFISETLKYNLGYQMNLKPAETCIIKLKKK
What are the official names of this protein?
Uncharacterized protein MJ0207.
Protein: DNLJ_SOLUE
Sequence: MKDPAVEIEKLREQLHHHEHLYYVLDKPEITDAEYDALMHRLQELETKHPDLLTPDSPTQRVGGKPREGFIKVRHSSPMLSLDNALNEAELRDFDRRVRDLLGGAAFRYVTELKMDGLSMAAHYNNGKFTEAVTRGDGTTGEDVTENARTIRSLPLRVKTKLPAFEVRGETVMSRRAFERLNTDRDEKGLSRFANPRNAAAGSLRQLEPQVTASRRLEYYTYFLLTEGRPAYESHWEALTALKQMGFKVNDKSRPCDSIDEVLAFCAHWEGERENLPYEIDGVVVKVDSVEQQRRLGFTAKAPRWAIAYKYPARQATTMIEGIDVQVGRTGALTPVANLKPVVVGGVTVSRATLHNEDEIERLGLQIGDEVVVERSGDVIPKVVRVSSQGSYRKPFKMPSHCPVCNTKIVREEGEAASRCINANCPARLKESILHFASRGVMNIDGMGDALVDQLVDREIVHNIADLYDLKIEDLMDLDRMGVKSAGNVIRNIDKSRRNSLPRVLTALGIRFVGERTAVFLAQAFGSMDAIERATVDELQQAEEVGPKVAEAVVQFFSIPDNRELVDRLRKADLQFTYAYSRPKGGPLTGSTFVLTGTLPNLSREEAKQLIEQAGGKVASAVSKKTSYVVAGEDAGSKLDKAHQLNIRVITEAELHAMLRGE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: VP7_ROTRF
Sequence: MYGIEYTTILIFLTSITLLNYMLKSITRIMDYIIYRFLLIVVILATIIKAQNYGVNLPITGSMDTAYADSTQSEPFLTSTLCLYYPVEASNEIADTEWKDTLSQLFLTKGWPTGSVYLKEYADIAAFSVEPQLYCDYNLVLMKYDSTQELDMSELADLILNEWLCNPMDITLYYYQQTDEANKWISTGSSCTVKVCPLNTQTLGIGCLITNPDTFETVATTEKLVITDVVDGVNHKLNVTTATCTIRNCKKLGPRENVAVIQVGGANILDITADPTTTPQTERMMRINWKKWWQVFYTVVDYVNQIIQTMSKRSRSLNSSAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: YIDC2_LISMF
Sequence: MKKKNIILISVLLGALLLLTGCSMDPSQNTDGFFSTYLIQPFTSFIMFVAKFVGGNYGIAIIITTLLIRALIMPLNLRTAKAQMGMQSKMAVAKPEIDEIQARLKRATSKEEQATIQKEMMAVYSKYNINPMQMGCLPLLIQMPILMAFYYAIRGSSEIASHTFLWFNLGSPDMVLAIIAGLVYLAQYFVSMIGYSPEQKKQMKIIGLMSPIMILFVSFTAPSALALYWAVGGLFLAGQTLLTKKLYMNKHPEIKVMEQEEKEFEQIVEEQKKEK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC 2, Foldase YidC 2, Membrane integrase YidC 2, Membrane protein YidC 2.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: O269_CONPE
Sequence: MEKLTILLLVAAVLMSTQALPQGGGENRLKENIKFLLKRKTAADRGMWGDCDDWLAACTTPSQCCTEVCDGFCRLWE
What are the official names of this protein?
Conotoxin PnMEKL-04.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACP_SALTY
Sequence: MSTIEERVKKIIGEQLGVKQEEVTNNASFVEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDYINGHQA
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP, Cytosolic-activating factor, CAF, Fatty acid synthase acyl carrier protein.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLCT_STAAR
Sequence: MGEYIVTKTLNNNVVVCTNNDQEVILIGKGIGFNKKEGMTLNDQTITIEKIYKLESEQQKAHYKSLVEIADDNVLQVIIDSLNFISNTAMNVDSKQLVVSLTDHIIFAYKRLKQNQVISNPFVMETMQLYSDAYHIAKQVIDQLNAALDVHFPEDEIGFIALHIASNTEDLSMHEMTLINNVIKKGIDIIESDLVTTVDKESLQYQRFIRHVQFLIRRLRRKEYIHAQDDFVSMIKNHYPICYNTAYKILTMIQKQFDVNISESEIIYLTLHIHHFEERINQS
What are the official names of this protein?
Protein GlcT.
What is the protein family that this protein belongs to?
Belongs to the transcriptional antiterminator BglG family. GlcT subfamily.
Protein: OR1G1_PANTR
Sequence: MEGKNLTSISEFFLLGFSEQLEEQKALFGSFLFMYLVMVAGNLLIILVIITDTQLHTPMYFFLANLSLADACFVSTTVPKMLANIQIQSQAISYSGCLLQLYFFMLFVMLEAFLLAVMAYDHYVAICHPLHYILIMSPGLCVFLVSASWIMNALYSLLHTLLMNSLSFCANHEIPHFFCDIDPLLSLSCADPFTNELVIFITGGLTGLICVLCLIISYTNVFSTILKIPSAQGKRKAFSTCSSHLSVVSLFXGTSFCVYFSPPSTRXAQKDTVASVMYTVVTPMLNPFIYSLRNQEIKSSLRKLIWVRKIHSP
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 1G1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DED1_CANAL
Sequence: MSDISKQMNNLSVNDGANTVNNNNSFRGGRSQYVPPHLRNRQGGGNQSGSSSESSDVPFGGSQRGGFNSNGFNNNRGGFNNGGYNNNRGGFNNGGFNNRGNYNQSFGGRGGRGGFNNGGGRYQRPTPGVGKWQDGKHEPAPRNEKLEVELFGTADDSHFQSSGINFDNYDDIPVEASGDKVPEPITSFTAPPLDELLVENIQLSRFTKPTPVQKYSVPIVAAGRDLMACAQTGSGKTGGFLFPVLSESYMKGPAPVPESNGAFSSHKVYPTILVMAPTRELVSQIYEESKKFSYRSWVRACVVYGGADIGQQMRNMDRGCDLLVATPGRLKDLLDRGKVSLANIRYLVLDEADRMLDMGFEPQIRYIVEECDMPAVKDRQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKILYVEDDEKKSVILDLLSANENGLTIVFTETKRMADNLADYLYDQGFPATAIHGDRSQYEREKALAAFKNGAAPILVATAVAARGLDIPNVSHVINYDLPSDIDDYVHRIGRTGRAGNVGIATAFFNRNNKNVVKGLIELLSEANQEVPDFLTKIAREGAFGKMTRGGGRGGSSRGPSRDFRRSGNSGWGNSGNSGWGNSGNASSSGWGGNSSSSYSNTNSNYGGGYNNNQRSNFSSGGSYGNQTGSNSWW
What is the function of this protein?
ATP-binding RNA helicase involved in translation initiation.  Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DED1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASSY_BARBK
Sequence: MNKWTDVKKVVLAYSGGLDTSIILKWLQSELGAEVVTFTADLGQGEELESARRKAEIMGIKEIYIEDLREEFVRDFVFPMFRANAVYEGVYLLGTSIARPLISKRLIEIAKETGADAIAHGATGKGNDQVRFELSAYALDPDIKIIAPWRDWTFKSRTDLIEFARVHQIPVEKDKEGEAPFSVDANLLHSSSEGKILENPAIPAPEYVHMRTLSPETAPDKATIITIGFKKGDAVSINGEMLSPATLLAQLNNYGRDNGIGRLDLVENRFVGMKSRGIYETPGGTILLTAHRAIESLTLDRGAAHLKDELMPRYAELIYYGFWFSPERKMLQAAIDLSQEHVEGEVTLKLYKGNVIVEGRQSKKSLYFDKLVTFEDDQGAYDQKDAAGFIKLNALRLRTLAARSSVL
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABCB6_MOUSE
Sequence: MVTVGNYCETEGPAGPAWTQNGLSPCFFFTLVPSTLLTLGVLALVLVLPRRRREVPAGPEELSWAAGPRVAPYVLQLFLATLQMALPLAGLAGRVGTARGVRLPGYLLLASVLESLASVCGLWLLVVERSQARQSLAMGVWMKFRHSLGLLLLWTVTFAAENLALVSWNSPQWWWARADLGQQVQFGLWVLRYVTSGGLFILGLWAPGLRPQSYTLHVHEEDQDVGGNQGRSTDRRSTWRDLGRKLRLLSSYLWPRGSPSLQLIVLICLGLMGLERALNVLVPIFYRDIVNLLTAKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFSIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENATRARAVDSLLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLGLLAGSLLCAYFVSEQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFHKGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEVEAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVIAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEESKPQDTA
What is the function of this protein?
ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:27507172).  May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:22294697, PubMed:17006453).  May play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (By similarity).  In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (By similarity).  In addition may play a role in the transition metal homeostasis (By similarity).
What are the official names of this protein?
ATP-binding cassette sub-family B member 6, ABC-type heme transporter ABCB6.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Lysosome membrane. Late endosome membrane. Early endosome membrane. Secreted, extracellular exosome. Mitochondrion. Endosome, multivesicular body membrane. Melanosome membrane. Note=Present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation. Traffics from endoplasmic reticulum to Golgi during its glycans's maturation, therefrom is first targeted to the plasma membrane, and is rapidly internalized through endocytosis to be distributed to the limiting membrane of multivesicular bodies and lysosomes. Localized on the limiting membrane of early melanosomes of pigment cells (By similarity). Targeted to the endolysosomal compartment (By similarity).
Protein: DEOD_PSYIN
Sequence: MTTPHINAVDGAFAETVLMPGDPLRAKYIAENFLKDAVQVTDVRNMLGFTGTYKGKRVSVMGSGMGIPSCSIYATELFREYGVQNIIRVGSCGAVSRDIKLRDVIIGMGASTDSKANRIRFKGHDFAAIASYELLEKAVNAARALGIKARVGNIFSADTFYTPEPEVFDTLEKYNILGVEMEAAGLYGVAAEEGKNALCILTVSDHIRTGEKTTSDERQSSFNEMLIIALDSIVAE
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.