PharMolix/UniProtQA huggingface dataset:
Protein: YCF2_NANDO
Sequence: MKQEAAKRHPFKSWIFELREILREIKNSHYFLDSWTKFDSVGSFTHIFFHQERFMKLFDPRIWSILLSRDSQGSTSNRYFTTKGVVLLVVAVLIYRINNRNMVERKNIYLMGLLPIPMNSIGPRNDPLEESFGSSNINRLIVSLLYLPKGKKISESCFMDPKESTWVLPITKKCIMPESNWGSRWWRNRVGKKRDSSCKISNETVAGIEISFKEKDIKYLESPFVSYTDDPIRKDHDWELFDRLSPRKKRNIINLNSGQLFEILVKHWICYLMSSFREKRLIEVEGFFKQQGAGSTIQSNDIEHVSHLFSRNKWGISLQNCAQFHMWQFRQDLFVSWEKNPHESDFFRNVSRENWIWLDNVWLVNKDRFFSFFSKVRNVSSNMQYDSTRSIFVQVTDSSQLKGSSDQSRDHFDSISNEDSEYHTLINQREIQQLKERSILWDPSFLQTERTEIESDRFPKCLSGYSSMSRLFTEREKQMKNHLLPEEIEEFLGNPTRSIRSFFSDRWSELHLGSNPTERSTRDQKLLKKQQDVSFVPSRRSENKEMVDIFKIITYLQNTVSIHPISSDPGCDMVPKDEPDMDSSNKISFLNQNDLFHDRNRGGYTLHHDFESEERFQEMADLLTLSITEPDLVYHKGFAFSIDSYGLDQKKFLNEVFNSRDESKKKSLLVLPPIFYEENESFYRRIRKKWVRISCGNALEDPKPKRVVFASNNIMKAVNQYRLIQNLIQIQYSIHGYIRNVSNQFFLMNRPDRNFEYGIQRDQIGNDTLNHRTIMKYTINQHLSNLKKSQKKWFDPLISRTERSMNRDPDAYRYKWSNGSKNFQEHLEHFVSEQKSRFQVVFDRLRINQYSIDWSEVIDKQDLSKSLRFFLSKLLLFLSKLLLFLSKSLPFFFVSIGNIPIHRSEIHIYELKGPNDQLCNQLLESIGVQIVHLNKLKPFLLDDHDTSQKSKLLINGGTISPFLFNKIPKWMIDSFHTRKNRRKSLDNTDSYFSMISHDRDNWLNPVKPFHRSSLISSFYKANRLRFLNNPHHFWFYCNKRFPFYVERARINNYDLTYGQFLNILFIRNKIFSLCVGKKKHVFLERDTPIESQVSNIFIPNDFPPSGDETYNLYKSFHFPIRSAPFVRRALYSIADISGTPLTEGQIVNFERTYCQPLSDMNPSDSEGKNLHQYLNFNSNMGLIHIPCSEKYLPSEKRKKRSLCLKKCVEKRQMYRPFQRDSAFSNFSKWNLFQTYMPWFLTSTGCKYLNFTLLDTFSDLLPILSSSQNFVSIFHDIMHGSDISWPIPQKKLWVILPQWNLISEISSKCLHNLLLSEEMIRRNNESPIPLIWAHLRSPNAREFLYSILFLLLVAGYLVRTHLLFVSRASSELQTEFEKIKSLMIPSYMIELRKLLDGYPTSELNSFWLKNLFLVALKQLGDFLEEIRGSASGGNMLLGGGPAYGVKSIRSKKKYLNINLIDIIDFLSIIPNPINRITFSRNTRHLSRTSKEIYSLIRKRKNVNGDWIDDKIESWVANSDSIDDEEREFLVQFSTLMKEKRIDKILLSLTHSDHLSKNDSGYQMIEQPGSVYLRYLVYIHKKYLMNYEFNRSCLAERRIFLAHYQTITYSQTSCGANSFHFPSHGKPFSLRLALSPSRGILVIGSIGTGRSYLVKYLTTNSYVPFITVFPNKFLDDKPKGYLIDDINIDDSDDIDDSDDIDDDLDIDTELLTMMNALTMDMTPKIDRFYITLQLELAKAMSPCIIWIPNIHDLSVNESNYLSLGLLVNHLSRDCERSSTRNILVIASTHIPQKVDPTLIAPNKSNTCIKIRRLLIPQQRKHFFTLSYTRGFHLEKKMFHTNGFGSITMGSNARDLVALTNEALSISITQKKSIIDTNTIRSALHRQTWDLRSQVRSVQDHGILFYQIGRAVAQNVLLSNCPIDPISIYMKKKSCTEGDSYLYKWYFELGTSMKKLTILLYLLSCSAGSVAQDLWSPPGPDEKNWITSYGFVENDSDLVHGLLEVEDALVGSSRTEKDCSQFDNDRVTLLLRSEPRNPLDMMQNGSCSIVDQRFLYEKYESEFEEGEGEGALDPQQLEEDLFNHIVWAPRIWRPCGNLFDCIESPNELGFPYWARSFRGKRIIDHEHEEDELQENDSEFLQSGTMQYQTRDRSFKEQGFFRISQFIWDPADPFFFLFKDQPFVSVFSRREFFADQEMSKGLLTSQTDPSTSMNKRWFINNTQEKHFELLIHRQRWLRTNSSLSNGSFRSNTPSESYQYLSNLFLSNGTLLDQMTKTLLRKRWLFPDEMKHLIHVTGERFPIP
What is the function of this protein?
Probable ATPase of unknown function.  Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.
What are the official names of this protein?
Protein Ycf2.
What is the protein family that this protein belongs to?
Belongs to the Ycf2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: NNMT_PIG
Sequence: MESGFTSKDAYLSHFNPQDYLEKYYNFGAKHSAEDQILRHLLKILFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIIATDYTDQNLQELEKWLKKEPGAFDWSPVVTYVCELEGNRVKGTEKEEKLRRAVKRVLKCDVTQSWPLGAVPLPPADCLLSTLCLHAACPDLPTYRTALGNLRSLLKPGGFLVLVDALKSSYYMIGEQRFSSLCLGQEAVEAAVREAGYTIEHFEVISQSYSSTMANNEGLFSLVGRKLSPCV
What is the function of this protein?
Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (By similarity).  Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases (By similarity).  Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3 (By similarity).  In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state (By similarity).  Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis (By similarity).  In white adipocytes, regulates polyamine flux by consuming S-adenosyl-L-methionine which provides for propylamine group in polyamine biosynthesis, whereas by consuming nicotinamide controls NAD(+) levels through the salvage pathway (By similarity).  Via its product N1-methylnicotinamide regulates protein acetylation in hepatocytes, by repressing the ubiquitination and increasing the stability of SIRT1 deacetylase (By similarity).  Can also N-methylate other pyridines structurally related to nicotinamide and play a role in xenobiotic detoxification (By similarity).
What are the official names of this protein?
Nicotinamide N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_RHOPS
Sequence: MVSSVAPPPEKMMFQLSLRRRGISDRAVLQAMEAVPRDRFVDPVHRDGAWRDTALPIACGQTISQPFVVAYMTEQLRLEAGHRLLEIGTGSGYHAAVLSRLVRDVVSVERFKTLADRARARLKELNYANVEVLLGDGFAIPEGAGTFDRIIVTAAMTELSQPLLDLLDPGGILIAPIGPANGRQTLIRVERKDDDFIRKALVDVRFVPALTGIAREL
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YYDH_BACSU
Sequence: MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLRFKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMNIVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLFINYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEYSRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN
What is the function of this protein?
Required for production of the modified peptide YydF (Probable).  May process the precursor form of YydF to release the active peptide (Potential).
What are the official names of this protein?
Putative peptide zinc metalloprotease protein YydH.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IF3_UREPA
Sequence: MSSNNDARKNQPLINDQIRFRTMVVIDDHGNNLGEMNRIDALNLAASKNLDLVVIAKKGNIPVTKILDYGKYKYEQKRRQKESRKNQTIIKVKEIKIKPMIGEHDLKVRAENAKRWLEDKDNVKFVIEARGRMCTKDEFIVQAYEKFIDLIKDYGTVVQANKKVSNYRYETIIEPIKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIGP_HUMAN
Sequence: MVPRSTSLTLIVFLFHRLSKAPGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN
What is the function of this protein?
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.
What are the official names of this protein?
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P, Down syndrome critical region protein 5, Down syndrome critical region protein C, Phosphatidylinositol-glycan biosynthesis class P protein, PIG-P.
What is the protein family that this protein belongs to?
Belongs to the PIGP family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HIS4_METNO
Sequence: MTRVILFPAIDLKEGRCVRLVQGDMAQAIVFSDDPAAQAASFAEQGFSWLHVVDLDGAFAGAPMNAAAVDAILAAVTIPVQLGGGIREMRTVEGWLAKGVSRVIIGTAAVRDPAFVREAARLFPGRIAVGIDAKDGRVAVEGWAKTSTVTAEELGRRFEDAGVAALIYTDIARDGVLKGLNIPMTLALAQAVSIPVIASGGLASIEDVHRILEPDCALLAGAITGRALYDGRIDPREALAAIRRAEEARRSGS
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CECC_DROTE
Sequence: MNFNKIFVFVALILAISLGQSEAGWLKKLGKRIERIGQHTRDATIQGLGIAQQAANVAATARG
What is the function of this protein?
Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Cecropin-C.
What is the protein family that this protein belongs to?
Belongs to the cecropin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CARA_NEOFI
Sequence: MFARVFKAMPARASALTSVNASIQARFMATVRQQRTAHERATFTIRDGPIFHGKSFGARTNISGEAVFTTSLVGYPESLTDPSYRGQILVFTQPLIGNYGVPSAERDQHGLLKYFESPNLQAAGVVVADVAEQYSHWTAVESLGEWCAREGVPAISGVDTRAIVTYLREQGSSLARITVGEEYDADQDEAFTDPEQIHLVRQVSTKAPFHVSAADPQCHVAVIDCGVKENILRSLVSRGASITVFPFDYPIHKVAHHFDGVFISNGPGDPTHCQETTYHLRRLMETSQVPIFGICLGHQLLALAAGARTIKLKYGNRAHNIPALDLSTGRCHITSQNHGYAVDASTLPSDWKPYFVNLNDSSNEGMIHKSRPIFSTQFHPEAKGGPLDSSYLFDIYIDSVKKYKASQAAFHPQRDSLPSPLLVDLLAKERVGVQPTIGMQNIAAAATAAAAAA
What are the official names of this protein?
Carbamoyl-phosphate synthase arginine-specific small chain, CPS-A, Arginine-specific carbamoyl-phosphate synthetase, glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DKGA_CORSC
Sequence: MTVPSIVLNDGNSIPQLGYGVFKVPPADTQRAVEEALEVGYRHIDTAAIYGNEEGVGAAIAASGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPTPAADNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATGVVPAVNQIELHPAYQQREITDWAAAHDVKIESWGPLGQGKYDLFGAEPVTAAAAAHGKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMDPGDGSGRVSAHPDEVD
What is the function of this protein?
Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).  5-keto-D-fructose and dihydroxyacetone can also serve as substrates.  25DKGR-A exhibits a greater selectivity for the substrate and higher thermal stability than 25DKGR-B.
What are the official names of this protein?
2,5-diketo-D-gluconic acid reductase A, 2,5-DKG reductase A, 2,5-DKGR A, 25DKGR-A, AKR5C.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKNF_MYCTO
Sequence: MPLAEGSTFAGFTIVRQLGSGGMGEVYLARHPRLPRQDALKVLRADVSADGEYRARFNREADAAASLWHPHIVAVHDRGEFDGQLWIDMDFVDGTDTVSLLRDRYPNGMPGPEVTEIITAVAEALDYAHERRLLHRDVKPANILIANPDSPDRRIMLADFGIAGWVDDPSGLTATNMTVGTVSYAAPEQLMGNELDGRADQYALAATAFHLLTGSPPFQHANPAVVISQHLSASPPAIGDRVPELTPLDPVFAKALAKQPKDRYQRCVDFARALGHRLGGAGDPDDTRVSQPVAVAAPAKRSLLRTAVIVPAVLAMLLVMAVAVAVREFQRADDERAAQPARTRTTTSAGTTTSVAPASTTRPAPTTPTTTGAADTATASPTAAVVAIGALCFPLGSTGTTKTGATAYCSTLQGTNTTIWSLTEDTVASPTVTATADPTEAPLPIEQESPIRVCMQQTGQTRRECREEIRRSNGWP
What is the function of this protein?
May play a role in the regulation of glucose transport, cell growth and septum formation.
What are the official names of this protein?
Serine/threonine-protein kinase PknF.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: NSE3_MOUSE
Sequence: MLQKPRGRGRPSTQADPERDWGGAGEEGPSTSRAAGGSSQGSRASLSAPTVGPRTQKQLELKVAELVQFLLIKDQKKIPIKRTDILKHVVGDYRDVYPNLLKLAAERLQYVFGYKLVELEPKSHSYILINMLEPVEADAEMRGDQGTPISGLLMIVLGLIFMKGNTITETEVWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPHTDPVDYELQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPTQYCEALADEESRARPATASAPATSS
What is the function of this protein?
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination.  The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.  The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).  In vitro enhances ubiquitin ligase activity of NSMCE1.  Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity).  May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (PubMed:14593116).
What are the official names of this protein?
Non-structural maintenance of chromosomes element 3 homolog, Non-SMC element 3 homolog, MAGE-G1 antigen, Necdin-like protein 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, telomere.
Protein: SYE_RHOPA
Sequence: MTRPVVTRFAPSPTGFLHIGGGRTALFNWLYARKHGGTMLLRIEDTDRQRSTQEAIDAILDGLKWLGIDWDGDTVYQFARAARHREVAEQLLAAGKAYRCYATAEELTAMRDKARAEGRAKLYDGSWRDRDPSEAPAGVKPTIRLKAPLTGETVIEDQVQGRVAWQNENLDDLVLLRGDGTPTYMLAVVVDDHDMGVTHVIRGDDHLINAARQKQIYDAMEWELPVMAHIPLIHGPDGSKLSKRHGALGVDAYRAMGYLPAALRNYLVRLGWSHGDQEIFTTQEMIDAFDLPAIGRSAARFDFAKLESLNGHYIRQSDDHSLVTLLEDLLKYIPQGPAIATKFDDSIRAKLTQAMPGLKERAKTLIELLDNAGFIFADRPLALDPKAQAVLTPETRQLIGRLRAALEDVSPWTAATTEAAMRAFAEQAGLKLGAVAQPLRVALTGRTTSPGIFDVLAVLGRDECLSRLADQSA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPF_TRIL1
Sequence: MIKVKICGITSPEDALTAVEAGADALGFVFYKESPRHIFPEEAARIINLLPPFVQAVGLFVNEAPEIVNQVSRNCRLGLVQLHGDETPDYCRKIEQRVMKAFRVRSLTCLDPIADYRMSGCLLDAYSPSFYGGTGKSFNWEIAREAMTRGHRIVLAGGLTPDNVAEAIRQVRPYAVDVSSGVESAPGRKDADKVREFIRNAKEAL
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: RECX_STAEQ
Sequence: MPKVTKIEVQKKNKERFNLFLDGEFEMGIDIDTLVKFNLKKDQILEPSDMQNIQEYDHYRRGVNLAIQYLSYKKRTEREVIQYLEKNDIQSNAIQDVIDYCYKEKFIDHEDYAESLKNTMIHTTDKGPEIYRQKLYQLGIEVTIIEKYVEAYEQQQPLDDVIKVAEKVMKSKKGPEAKVKQKVTQSLLQKGYKFETIQLVMNEIDFSQDEETLDHLLQRDLEKVYNKNCRKYDSDKSVIKTIEALMRKGYNYDKIKSKLEESGISNE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KEAP1_PONAB
Sequence: MQPDPRPSGAGACSRFLPLRSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVTKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination.  KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes.  In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes.  In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2.  The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (By similarity).  The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
What are the official names of this protein?
Kelch-like ECH-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the KEAP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly cytoplasmic. In response to selective autophagy, relocalizes to inclusion bodies following interaction with SQSTM1/p62.
Protein: MURC_MYCBT
Sequence: MSTEQLPPDLRRVHMVGIGGAGMSGIARILLDRGGLVSGSDAKESRGVHALRARGALIRIGHDASSLDLLPGGATAVVTTHAAIPKTNPELVEARRRGIPVVLRPAVLAKLMAGRTTLMVTGTHGKTTTTSMLIVALQHCGLDPSFAVGGELGEAGTNAHHGSGDCFVAEADESDGSLLQYTPHVAVITNIESDHLDFYGSVEAYVAVFDSFVERIVPGGALVVCTDDPGGAALAQRATELGIRVLRYGSVPGETMAATLVSWQQQGVGAVAHIRLASELATAQGPRVMRLSVPGRHMALNALGALLAAVQIGAPADEVLDGLAGFEGVRRRFELVGTCGVGKASVRVFDDYAHHPTEISATLAAARMVLEQGDGGRCMVVFQPHLYSRTKAFAAEFGRALNAADEVFVLDVYGAREQPLAGVSGASVAEHVTVPMRYVPDFSAVAQQVAAAASPGDVIVTMGAGDVTLLGPEILTALRVRANRSAPGRPGVLG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDS1_YEAST
Sequence: MSFTGSLALAGIGGLVYKFGGGQSYEKLPYVNIPFNQYLDKVYKKHFSKVMSRTRYVLMNFFKDAFTGGAFMYPFKGFLEFNTNKSSYSTTMLGILSSYLIMFALVSFVYWATITPMYTAFLIVLGPIGLFIAIFHSFLQANVFTLLFMRLSHFNNHLVEVCLEKNGLEENLSEVKPIKYYAPINSIYFWAYYFPFKLVKYMLGLSVLFVLLVISFFPLIGPILFHILISPFITQIYFTKVLRLQNFDNIQRRENIYLHAGQYASFGFLAGLIESVPILAGFAISTNTIGSVLFNLDHPMVPENLVETQAEIEAAPQDINQQPNQ
What is the function of this protein?
Involved in spore wall assembly.
What are the official names of this protein?
Outer spore wall protein LDS1, Lipid droplets in sporulation protein 1.
What is the protein family that this protein belongs to?
Belongs to the LDS family.
What are the subcellular locations of this protein?
Prospore membrane; Multi-pass membrane protein. Lipid droplet. Spore wall. Note=Localizes to the ascal side of growing prospore membranes in mid-meiosis II and to the spore wall in post-meiotic cells. Localizes to a specific subset of lipid droplets associated with the exterior surface of the spore throughout spore wall formation.
Protein: YO9_ADEG1
Sequence: MEPPHNSPVPFSIAKMGNPTLLLLSGLLSLTQAISIGEHENKTRHVIVWRHSSSHQCSDWRTVTEWFPPQKGNPVRPPYTQRVSLDTANNTLTVKPFETNNGCWETTSQGINHPPTTIQYRVWNITTTPTIQTINITKITVREGEDFTLYGPVSETMSIIEWEFIKDVTPQFILQYYLSINSTIVYASYQGRVTFNPGKNTLTLKGAKTTDSGTYKSTVNLDQVSVHNFRVGVTPIEKKEEATAETPASKPTPIPRVRADARSTALWVGLALCILTVIPALIGWYFRDRLCVPDPIIELEIPGQPHVTIHILKGPDDDCET
What are the official names of this protein?
Uncharacterized protein ORF9.
Protein: CYB_TODTO
Sequence: MAPNPRKSHPILKMVNNSLIDLPTPPNISAWWNFGSLLGICLVTQILTGLLLATHYTADTSLAFSSVAHTCRNVQYGWLIRNLHANGASLFFICIYLHIGRGLYYGSYLYKETWNTGVILLLSLMATAFVGYVLPWGQMSFWGATVITNLFSAFPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFLIAGLTLTHLTFLHETGSNNPLGLISNCDKIPFHPYFSPKDLLGFILMFLPLTALALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLAPFLHKSKQRTMTFRPLSQLLFWILVTNLLILTWVGSQPVEQPFIIIGQLASLAYFIILLILFPIIGALENKMLNF
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VIF_SIVGB
Sequence: MERVERIVRLTWKVSSQRIEKWHWLVRRQMAWATANNEEGCWWLYPHFMAYNEWYTCSKVVIIINRDIRLIVRSYWHLQIEVGCLSTYAVSIEAVVRPPPFEKEWCTEITPEVADHLIHLHFYDCFMDSAVMKAIRGEEVLKVCRFPAGHKAQGVLSLQFLCLRVIYGPEER
What is the function of this protein?
Counteracts the innate antiviral activity of APOBEC3G.  Forms a complex with host APOBEC3G thus preventing the entry of this lethally hypermutating enzyme into progeny virions.  Functions as an adapter molecule, recruiting APOBEC3G to the ubiquitin-proteasome machinery.  Targets APOBEC3G for degradation through the assembly with elongin BC complex, CUL5 and RBX1.  Binds viral RNA and affects the stability of viral nucleoprotein core.  May play a role in viral morphology (By similarity).
What are the official names of this protein?
Virion infectivity factor, Vif, Q protein, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=Seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor (By similarity).
Protein: MRAZ_SALNS
Sequence: MFRGATLVNLDSKGRLTVPTRYREQLIESATGQMVCTIDIHHPCLLLYPLPEWEIIEQKLSRLSSMNPVERRVQRLLLGHASECQMDGAGRLLIAPVLRQHAGLTKEVMLVGQFNKFELWDETTWYQQVKEDIDAEQSATETLSERLQDLSL
What is the function of this protein?
Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster.  Acts by binding directly to DNA.  May also regulate the expression of genes outside the dcw cluster.
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: RLME_ECOL6
Sequence: MTGKKRSASSSRWLQEHFSDKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYVVTQIGGKGRIIACDLLPMDPIVGVDFLQGDFRDELVMKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALEMCRDVLAPGGSFVVKVFQGEGFDEYLREIRSLFTKVKVRKPDSSRARSREVYIVATGRKP
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.