PharMolix/UniProtQA huggingface dataset:
Protein: CCKAR_MOUSE
Sequence: MDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSAVQILLYSFIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLIPGVVMVVAYGLISLELYQGIKFDASQKKSAKEKRLSSGGGGGGGSSSSRYEDSDGCYLQKSRPPRKLELQQLSTSSSGGRINRIRSSGSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPTGVRGEVGEEEDGRTIRASLSRYSYSHMSTSAPPH
What is the function of this protein?
Receptor for cholecystokinin.  Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach.  Has a 1000-fold higher affinity for CCK rather than for gastrin.  It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system.  This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).
What are the official names of this protein?
Cholecystokinin receptor type A, CCK-A receptor, CCK-AR, Cholecystokinin-1 receptor, CCK1-R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YCF2_GOSHI
Sequence: MKGHQFKSWIFELREILREIKNSHYFLDSWTQFNSVGSFIHIFFHQERFIKLLDPRIWSILLSRNSQGSTSNRYFTIKGVVLFVVAVLIYRINNRNMVERKNLYLTGLLPIPMNSIGPRNDTLEESFGSSNINRLIVSLLYLPKGKKISESCFLDPKESTWVLPITKKCIMPESNRGSRWWRNWIGKKRDSSCKISNETVAGIEISFKEKDIKYLEFLFVYYMDDSIRKDHDWELFDRLSPSKRRNIINLNSGQLFEILVKDWICYLMFAFREKIPIEVEGFFKQQGAGSTIQSNDIEHVSHLFSRGKWAISLQNCAQFHMWQFRQDLFVSWGKNPHESDFLRNISRENWIWLDNVWLVNRDRFFSKVRNVSSNIQYDSTRSSFVQVTDSRQLKGSSDQSRDRFDSISNEDSEYHTLINQREIQQLKERSILWDPSFLQTERTEIESDRFPKCLSGYSSMSRLFTEREKRMNNHLLPEEIEEFLGNPTRSIRSFFSDRWSELHLGSNPTERSTRDQKLLKKEQDVSFVPSRRSENKEIVNIFKIITYLQNTVSIHPISSDPGCDMVPKDELGSSNKISFLNKNPFFDLFHLFHDQNRRGYTLHHDFESEERFQEMADLFTLSITEPDLVYYKGFAFSIDSYGLDQKQFLNEVFNSRDESKKKSLSALPPIFYEENESFYRRIRKKWVRISCGNDLEDPKPKIVVFASNNIMEAVNQDRLIRNLIQIQYSTYGYIRNVLNRFIKKNRSDRNFEYGIQRDQIGNDTLNHRTIMKYTINQHLSNLKKSQKKWFDPLILISRTERSMNRDPNAYRYKWSNGSKNFQEHLEHFVSEQKSRFQVVFDRLRINQYSIDWSEVIDKKDLSKSLRFFLSKLLLFLSKLLLFLSNSLPFFFVSFGNIPIHRSEIHIYELKGPNDQLCNQLLESIGLQIVHLKKLKPFLLDDHNTSQKPKFLINGGTISPFLVNKIPKWMIDSFHTRNNRRKSFDNMDFSMISHDQDNWLNPVKPFHRSSLISSFYKANRLRFLNNPHHFCFYCNKRFPFYVEKARINNYDFTYGQFLNILFIRNKIFSLCGGKKKHAFLGRDTISPSPIESQVSNIFISNDFPQSGDERYNLYKSFQFAIRSDPLVRRAIYSIADISGTPLTEGQIVNFERTYCQPLSDMNPSDSEEKNLHQYLNFNSNMGLIHTPCSEKYLPSEKRKKRSLCLKKCVEKGWMYRTFQRDSAFSTLSKRNLFQTYMPWFLTSTGYKYLNLIFLDTFSDLLPILSSSQKFVSIFHDIMHGSDISWRILQKKLCLPQWNLISEISSKCLHNFLLSEEMIHRNNESPLISTHLRSPNVQEFLYSILFLLLVAGYLVRTHLLFVSRAYSELQTEFEKVKSLMIPSYMIELRKLLDRYPTSELNSFWLKNLFLVALEQLGDSLEEIRGSAFGGNMLWGGGPAYGVKSIRSKKKYLNINLIDIIDLISIIPNPINRIIFSRNTRHLSHTSKEIYSLIRKRKNVSGDWIDEKIESWVANSDSIDDKEREFLVQFSTLTTEKRIDQILLSLTHSDHLSKNDSGYQMIEQPGPIYLRYLVDIHKKYLMNYEFNTSCLAERRIFLAHYQTITYSQTSCGANSFHFPSRGKPFSLRLALSPSRGILVIGSIGTGRSYLFKYLATNSYVPFITVFLNKFLDNKLKGFLIDDIDIDDSDDIDASDDIDASDAIDDSDAIDRDLDTELELLTMMNALTMDMMSEIDRFYITLQFELAKAMSPCIIWIPNIHDLDVNEANYLSLGLLVNYLSKDCERCSTRNILVIASTHIPQKVDPTLIAPNKLNTCIKIRRLLIPQQRKHFFTLSYTRGFHLEKKMFHTNGFGSITVGSNARDLVALTNEALSISITQKKSIIDTNTIRSALHRQTWDLRSQVRSVQDHGILFYQIGRAVVQNVLLSNCPLDPISIYMKKKSCNEGDSYLYKWYFELGTSMKKLTILLYLLSCSAGSVAQDLWSLPGPDEKNGITSYGFVENDSDLVHGLLEVEGALVGSSRTEKDCGQFDNDRVTLLLRSEPGNPLYMMQNGSCSIVDQRNLYEKYESEFEEGEGEGVLDPQQIEEDLFNHIVWAPRIWRPWGFLFDCIERPNELGFPYWAGSFRGKRIIYDEKDELQENDSAFLQSGTMQYQARDRSSKEQGFFRISQFIWDPADPLFFLFKDQPFVSVFSHREFFADEEMSKGLLTSQTDPPTSIYKRWFIKNTQEKHFELLIHRQRWLRTNSSLSNANGFFRSNTPSESYQYLSNLFLSNGRLLDQMTKTLLRKRWLFPDEMKIGFM
What is the function of this protein?
Probable ATPase of unknown function.  Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.
What are the official names of this protein?
Protein Ycf2.
What is the protein family that this protein belongs to?
Belongs to the Ycf2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RS3_FRATW
Sequence: MGQKVNPNGIRLGYIRDWRSTWYADSSRYATKLNEDIKVREFLHKKLAAAAVSKIQIERPAQNAKITIHTARPGIVIGKKGEDVEKLRAEVHKLMGIPVQINIEEVRKPEIDAKLVAESVAQQLEKRVMFRRAMKKAMQAAMKSGAKGIKIMVSGRLGGAEIARSEWARDGRVPLQTFRADVDYATAEALTTYGVIGVKVWIYKGEILPGQIAEKKNNKKGAK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: VPU_HV1Z8
Sequence: NQSERAEDSGNESDGDKDELSTLVEMGHHAPWDIDDM
What is the function of this protein?
Enhances virion budding, by targeting human CD4 and Tetherin/BST2 to proteasome degradation.  Degradation of CD4 prevents any unwanted premature interactions between viral Env and its receptor human CD4 in the endoplasmic reticulum.  Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane.  Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation.  The alteration of the E3 ligase specificity by Vpu seems to interfere with the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis.  Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers.  It is thus unsure that this activity plays a role in vivo (By similarity).
What are the official names of this protein?
Protein Vpu, U ORF protein, Viral protein U.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 VPU protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass type I membrane protein.
Protein: G6PI_BURP6
Sequence: MTLNSLPVWPALQAHYEEIRDAHLRDWFAPANDRAPTRAERFTFEGGGLAADFSKNRLTDATLALLVRLAREAGVEARRDAMFAGETVNPTEGRAALHTALRANAADAPFQAQVAAERAKMARFADAVRSGAWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALHHVATPDIATHFVSNVDGADLARVLERIDPEETLAIIVSKTFTTLETMTNARSLRDWFVANGCPEGALAKHFVGVSANPAEVVKFGIAEANVFEMWDWVGGRYSLWSAVGLSIMIAIGPERFDELLAGARDMDEHFRTAPLERNLPALQGLVGIWYRNFFGAQSYLVAPYSEALHYLPSYLQQLEMESNGKSARIDGAFVDYPTSAVTWGEPGTNGQHAFFQMLHQGPTLVPIDFIAVLTPEHPLASHHPKLLANCFAQSEALMLGRTLDEARKIAGPAKPELAPHLTFPGNRPTTTLLVDALTPRTLGALIALYEHKVLVQAAVWNINPFDQWGVELGKILGKVVEADLTAAQVDPAKHDSSTSALIARARKALGE
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNS1_CANGA
Sequence: MSTEKQYQPQQPPPAYTGQGPDNGNAYGYPESYGKTETHSGDSCSGDTSMNPQQQGQQYQFRKDDEFYNLNHEGAGAPIGSYAEVFPTEDNNKPKFNDWPFIIVFLLTLCGFIVVASLTLRAWSQTYSSTGSGIYHDFDTGTLNTNSVILLVFSVVIAIFFAFIGIVLCRAYPKFFIYAGMIVNILAALGTAIMYMSLKYWSAGIVFLIFTFMTAWCYWGMRSRIPLTVAILRVIVLAMKNCPQSLFVSFFGTIVASAFAMLFSTVVVATYMKYDPSNTNSGCNVSGGDCSHAKLIGVLVVVFFCGYYISEVIRNVMHCTVSGVFGSWYYRYKSDQGMPKWPAMGAFKRAMTYSFGSICFGSLIVSIIETFRQLLQLGKQAAIASTDNANWIRIIFWLIDMLVGFIQWIAQYFNHYAYCIIALYGKPYLKAAKQTWYMFREKGIDALINDNLVNVALGFYSLFASYMSCLFAFLYLRFTKPGYNSDGDFNAPLMAFAFVIALQLTNIANETIRSGCATFFTALGHDPEVFQAQYPDRFDEIFRSYPQVLNKLTHQDV
What is the function of this protein?
Probably involved in transport through the plasma membrane.
What are the official names of this protein?
Protein PNS1.
What is the protein family that this protein belongs to?
Belongs to the CTL (choline transporter-like) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KDSB_HELAH
Sequence: MIIIPARLKSSRFENKVLECIFGLPMVVRCAKNASLVDECVVACDDESIMEVCQKFHIKAVMTSKHHNSGTERCLEAAQLLGLKNDERVLNLQGDEPFLEKEVIAMLLEATKNAPFMATCAKVIDKEKAKNPNLVKVVLDHQNNALYFSRSLIPFLRDFDLKRPTPLLGHIGIYGFHNREILEELCSLKPCVLEEIEKLEQLRALYYQKNILVKIVQSESVGIDTKEDLQNALKIFNSLPTTP
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIF1A_CHICK
Sequence: MDSPGGVTDKKRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHTVSAHLDKASIMRLTISYLRMRKLLDAGELETEANMEKELNCFYLKALDGFVMVLSEDGDMIYMSENVNKCMGLTQFDLTGHSVFDFTHPCDHEELREMLTHRNGPVKKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRVYDTCNNQTHCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQKDLIFSLGQTECMLKPVESPEMKMTKIFSKDDWDDTNSLFEKLKQEPDALTVLAPAAGDTIISLDFSSNESDEQQCDEVPLYNDVMLPSSSEKLQNINIAMSPLPASETTKPLRSNADPALNREVVSKLEPNTETLELSFTMPQVQEQPTSPSDASTSQSSPEPSSPNDYCFDVDNDMANEFKLELVEKLFAIDTEAKNPFSTQETDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSSGSQNAATITILQQTQTPSTAADEIKPVAERVDDVKALIVPSSPVHVINDTSSAPASPYSGNRSRTASPIRAGKGTLEQTEKSCPGAPSLITVTLNKRSTAMDEELNPKMLALHNAQRKRKMEHDGSLFQAVGIGSLFQQTGDRGGNASLAWKRVKACKTNGHNGVEQKTIILLSTDIASKLLGQSMDESGLPQLTSYDCEVNAPIQGNRNLLQGEELLRALDQVN
What is the function of this protein?
Functions as a master transcriptional regulator of the adaptive response to hypoxia.  Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia.  Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
What are the official names of this protein?
Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia.
Protein: RL2_AERPE
Sequence: MGKRLRQQRAGRGTPTYRSRAHIHPGPAKYPPLSGDTLRGKVVELIHDPGRYVPLARVVREDGVEFLMPAAEGMYVGQIIEIGPAAKPEAGNILPLGKIPEGTEVFNVELRPGDGGKLARQAGSYALVVGRAGAKTILRLPSGKDKEVPNDSRATIGIPAGAGRIEKPIMKAGFAYHKWKVKARKWPRVRGVAMNAVDHPFGGGRHQHKGRPSTVARTAPPGRKVGHIAARRTGRRKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: YZ22_AQUAE
Sequence: MDIKLDKNVVKMVMSSKEEELMPSIGWEGKKEIPVLITNVETKIPKGHPVIFKMVPIDEGKVTAVFIFLTVGEQLWTVFNPANTYYRLFLKAMTEADKLAICFPNKKAISIKTTEEMKKAARILLDTIEEFQWDSEEFAEALEKIAENYTLEDIEMIAVQEWKKRTGQEKEN
What are the official names of this protein?
Uncharacterized protein aq_aa22.
Protein: MNMG_ECOUT
Sequence: MFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVGRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRSNLDRSPMYAGVIEGVGPRYCPSIEDKVMRFAERNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIQGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEIGRELGLVDDERWARFNEKLENIERERQRLKSTWVTPSAEAAAEVNAHLTAPLSREASGEDLLRRPEMTYEKLTTLTPFAPALTDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATF_METBF
Sequence: MELAVIGKSEFVTGFRLAGVRKVYETADIAATESVVKSVLEDKSVGILVMHNDDIGNLPEMLRKNLNESVQPTVVALGGSGSGSNLRDKIKQAVGVDLWK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit F, V-ATPase subunit F.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase F subunit family.
Protein: RS7_BRUAB
Sequence: MSRRHKAEKREINPDPKFGDLVITKFMNAVMLHGKKSVAESIVYGALDAIEAKAKSEPVALFHQALDNVAPHIEVRSRRVGGATYQVPVDVRPERRQALAIRWLINAARGRNETTMVDRLSGELLDAANNRGSAVKKREDTHRMAEANRAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: COX9_ASHGO
Sequence: MSAIAPITGSLKKRIMKDIAVGMGLGTVLGSYWWWGFHKPKIAARENYYTQLAEQKAAEE
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 9, mitochondrial, Cytochrome c oxidase polypeptide VIIA.
What is the protein family that this protein belongs to?
Belongs to the fungal cytochrome c oxidase subunit 7a family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: BLNK_HUMAN
Sequence: MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPKPKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKAPMVNRSTKPNSSTPASPPGTASGRNSGAWETKSPPPAAPSPLPRAGKKPTTPLKTTPVASQQNASSVCEEKPIPAERHRGSSHRQEAVQSPVFPPAQKQIHQKPIPLPRFTEGGNPTVDGPLPSFSSNSTISEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVVFFNKRVYNIPVRFIEATKQYALGRKKNGEEYFGSVAEIIRNHQHSPLVLIDSQNNTKDSTRLKYAVKVS
What is the function of this protein?
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development.  Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK.  Modulates AP1 activation.  Important for the activation of NF-kappa-B and NFAT.  Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes.  However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling.  May be required for the RAC1-JNK pathway.  Plays a critical role in orchestrating the pro-B cell to pre-B cell transition.  May play an important role in BCR-induced B-cell apoptosis.
What are the official names of this protein?
B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction.
Protein: VKT1_TROCA
Sequence: MSSGGLLLLLGLLTLWEGLTPVSSKDRPDFCELPDDRGPCRGIFHAFYYNPDQRQCLEFIYGGCYGNANNFKTIDECERTCAA
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Kunitz-type serine protease inhibitor carinatin-1.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1491_METJA
Sequence: MKYMVSFDQERMLKPAVIGGIINGILGAICCLCYVIGGAVAAHLYVNAGGICDYENCGLVGAISGVIGGVIASILSFLFMSAYLSALGLKAAMFTGASFIIGFITAIIFGAILGAVGGVIYVVIKNR
What are the official names of this protein?
Uncharacterized protein MJ1491.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CP6B2_HELAM
Sequence: MWIFYFPAVISVLIVTLYFYFTRTFNYWKKRNVRGPEPVVFFGNLKDSALRKKNMGVVMEELYNMFPEEKVIGIYRMTSPCLLVRDLEVIKHIMIKDFEVFSDRGLEFSKEGLGQNLFHADGDTWRTLRNRFTPIFTSGKLKNMFYLMNEGADNFIDHVSKECEKHQEFEIHTLLQTYTMSTISSCAFGVSYDTISDKLDTLAIVDKIISEPSYAIELDMMYPGLLPKLNLSIFPSVVHKFFKNLVNTIVTQRNGKPSGRNDFMDLILELRQMGEITSNKYGNNMSTLEITESVMCAQAFVFYIAGYETSATTMAYLTYQLALNPDIQNKLIAEIDEAIKANGGKVTYDTVKDMKYLNKVFDETLRMYSIVEPLQRKAIRDYKLPGTDVVIEKDTVVLISPRGIHYDPKYYDNPKQFNPERFFAEEVGKRHPCAYLPFGLGQRNCIGMRFGRLQSLLCITKLLSKFRLEPSKNTDRNLQVEPYRFIIGPKGGIRLNIVPRKDVS
What are the official names of this protein?
Cytochrome P450 6B2, CYPVIB2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: ECFA1_MYCPN
Sequence: MLNTNKQAAASFQGVYFSYSELPLIRNLSFDVFEGEYVCIVGHNGSGKSTISKLLTGLLKPQAGTIKIFGKTISSENVTYLRNHIGIIFQNPDNQFIGITVEDDIAFGLENRRYTREKMKSIIEDVAQQAGITELLQKEPHNLSGGQKQRVAIASVLALNPAIIIFDESTSMLDPKAKRTIKQFMVELRNQGKCVISITHDMEEVTKADKVLVMNEGRLIRQGKPKDVFNSAAELQKIRLDIPFSLSLSTKVNGVTSTIDYQQLIEAIGKLWKK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UBA3_DANRE
Sequence: MAEGEEPEKKRRRIEELNEKMVVDGGSGDRSEWQGRWDHVRKFLERTGPFTHPDFEASTESLQFLLDTCKILVIGAGGLGCELLKDLALSGFRHIHVVDMDTIDVSNLNRQFLFRPKDVGRPKAEVAADFVNDRVPGCSVVPHFKKIQDLDETFYRQFHIVVCGLDSVIARRWMNGMLLSLLIYEDGVLDPSSIIPLIDGGTEGFKGNARVILPGMTACIDCTLELYPPQINFPMCTIASMPRLPEHCVEYVRMLLWPKEKPFGDGVVLDGDDPKHIQWVYQKSLERAAEFNITGVTYRLTQGVVKRIIPAVASTNAVIAAACATEVFKIATSAYVPLNNYLVFNDVDGLYTYTFEAERKENCSACSQVPQDMQFTPSAKLQEVLDYLTENASLQMKSPAITTTLDGKNKTLYLQTVASIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLKFIS
What is the function of this protein?
Catalytic subunit of the dimeric uba3-nae1 E1 enzyme.  E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP.  E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity).
What are the official names of this protein?
NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
Protein: DER_MARSD
Sequence: MLPTIALIGRPNVGKSTLFNRLLRKKRAITHDMPGITRDRIYAEGNYNGVHYALIDTGGLVMESDNNSEEFQGDIFEQAREAIEEAQALILVVDGRTGITQLDEQVAAYIRQSNKPILLLVNKVDGSELEATATADFHALGFEMMAVSAEHGFNLLELREKVADMALATGIEYEEEDEEAKGLKIAMLGRPNAGKSSMVNALTGEERVIVSDVAGTTRDSVDVTFESGGKIYTFVDTAGVRRRTNITDTIERFSVVRALRSSTKADITVMVVDALAGITKQDKRLLEYLLREAVPFIIAVNKIDLVSKSERNLLREGFERALRMAHHVPVVYTSCISKSGLGGILPLASKLKAECSLRISTGQLNRIMKEIIEKHQPPVVKRRRAKFKYMTQADDEPPTFIFFINDEKLIKSSYHRFLENRLRKILNVKHAPLNIVFRSTFRAKEDIVHK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: FLGI1_CERS4
Sequence: MRRALLLAALLACAPPAFADRLKDLTTVAGVRSNPLVGYGVVVGLSGTGDGNSQLTQQSMQSLISRLGLSVETGDLKAKNAAAVMVTADLPPFLKIGQTLDVTVSTVGQAKSLKGGTLLMTPLMGADGEVYAIAQGNLVVGGLGVEGKDGSSLTVNIPTVGRVPRGGMVEKMVETPFLETDHLVLNLNRGDFSTAAAVAEGVNRTFGPDVAVALDGTSIRVRAPADPARRVSFMSLLENVEVDPAPPVARVVVNARTGTVVIGGTVKVTPAAVTHGSLTVRVTEDQRVSQGASVVVGNNATVVAPGEPVVTPDSQVQVVEEPAKAFVFDPGVSLSSLVDAINAVGASPSDLVAILEALREAGALRAELVVI
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein 1, Basal body P-ring protein 1.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: GLYA_STRE4
Sequence: MMFNNENYKDYDQELWEAIQAEEDRQEHNIELIASENMVSKAVMQAQGSVLTNKYAEGYPSKRYYGGTEYVDIVESLAIERAKKLFGAAYANVQPHSGSQANAAAYMALINAGDTVLGMDLAAGGHLTHGSPVNFSGKTYQFVGYTVDKETEKLDYAAILKQAKAVQPKLIVAGASAYSRQIDFEQFRFIADQVGSYLMVDMAHIAGLVAAGLHQNPVPYAHIVTSTTHKTLRGPRGGLLLTNDEAISRKMNAAIFPGLQGGPLEHVIAAKAVAFKEALDPAFTDYARAVIANTAAMAEVFAKDDRFRLISGGTDNHLFLVDVTKVIENGKLAQALLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMGVDESRTIAHLIIKALVNHQQPEILEEVRYEVRRLTDAFPLYKKN
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.