PharMolix/UniProtQA huggingface dataset:
Protein: TOF1_PICST
Sequence: MSVSDIETERTRYYDAYDADDAELDGFIVSDEENDNLENENRNERDPDSRNQDDVDEYGQPQIDRIRTMTEALAPNESQASKVLRAHISVLVSALGGPDHTSNISPPPYKLGHDALACLKDIKRWIKSVDDRQDSYQVALACAESGLVINDLIVILCQWDSKNKKKEDFRNKRTMEKIMLACLELLVLLTWSVELRPESSDKQKLLYYDVKKAQIKYKRAILTYNKGQTLKAVIRLVLPIISKERVDREPKDNAIMRLVLFFFRNILYVEPPSPSISKKSSKTIVVTDNMPEGVSYDDISLSATISAFSKNRVLMLFLTLSSGIGVDFDSRFLGPTLLECIHLLVRGVDPNDILKLKQMRIPTEINDPGNSSSPFHNVPPASSTTGLQLQDLLAKESKIKNSQTQSMSTRHGRFGSLLSIRGDHSMSFVVSGQEALINAGQTMQKLDRSKKWKNRSYFKYDSDEYTKSSNTTYMNYGGLVILHEFIESFLAGGCFNILIEKLSSVFSSSDSILEKEYETATFFLTIAWFFQYKREKTVLYSSGTTNLQPIGEEDDRNDFGSVGAALSQVNFILLVKYCVDSFSISPKRWSSLHVVLICLKELLEISNTLFTRSSSSAGDEEQNELDRELAEGIISHLLVTQDFLSILYHLPQTASRHSPEYLKVCISVVHILLKTLKNFAEEDVKLFIQTTRRNSKKKANKESNDQSDAVEQVDESDTEDKRTHARVTRERKINYERTEVKFFHQDTVSTYIEYLSRYEDLTHYEIKKCLTYFHRLFVVRKDFNGLYRLDFMQVLHKLRDYLPSQSNIRGQVDEFIYYFMKKFKASIERFPNPIEILFPRFEDAESKTYLATGELYIQTEREIRSANVKRFEPGKPLEFVRHFEDNEKYKILVSALYEQGLSNMLVCLVEDLQRIHGIKQLDEDVDEVLQLKEDFRQYVLTNSHLRLLLRTVGLIPGYSLSQECQVPSKLTSSDIDSAITLIKKWMGLQPATFEDGKDPSYFLRSTGDTVDRPIDYSDSEDDIAFEITPKDRPNESHYDMLTELDELERAISGAENREKGKARKRGNKSSSTIKKKSLQSRSRRPPRFNVDSDDESELRKEVKSSEFVHDSDDESDDEAFFEREERLRQMLNSSGGIVNAQQLSEFKKVWASLESTGGIATASQVVRAVESVANISDGVDTHSHQDDKSQPSDSENEDSSEEVSEVQIRKRLRIEDDENDSDNNVSENYVSAEEGEEATPTVKRKKRLVISDDEDE
What is the function of this protein?
Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair.  FPC coordinates leading and lagging strand synthesis and moves with the replication fork.  FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
What are the official names of this protein?
Topoisomerase 1-associated factor 1.
What is the protein family that this protein belongs to?
Belongs to the timeless family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HBB_PANTR
Sequence: MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: DINI_ECOL6
Sequence: MRIEVTIAKTSPLPAGAIDALAGELSRRIQYAFPDNEGHVSVRYAAANNLSVIGATKEDKQRISEILQETWESADDWFVSE
What is the function of this protein?
Involved in SOS regulation.  Inhibits RecA by preventing RecA to bind ssDNA.  Can displace ssDNA from RecA (By similarity).
What are the official names of this protein?
DNA damage-inducible protein I.
What is the protein family that this protein belongs to?
Belongs to the DinI family.
Protein: DI3L2_HUMAN
Sequence: MSHPDYRMNLRPLGTPRGVSAVAGPHDIGASPGDKKSKNRSTRGKKKSIFETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDGVVARNRALNGDLVVVKLLPEEHWKVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYNDSPDVIVEAQFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRALSEKSLQRSAKVVYILEKKHSRAATGFLKLLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQDFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVLECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFVPEGSDLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFGRTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPPPQTRMLSDLVEFCDQMGLPVDFSSAGALNKSLTQTFGDDKYSLARKEVLTNMCSRPMQMALYFCSGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRLLAAALGYRERLDMAPDTLQKQADHCNDRRMASKRVQELSTSLFFAVLVKESGPLESEAMVMGILKQAFDVLVLRYGVQKRIYCNALALRSHHFQKVGKKPELTLVWEPEDMEQEPAQQVITIFSLVEVVLQAESTALKYSAILKRPGTQGHLGPEKEEEESDGEPEDSSTS
What is the function of this protein?
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation.  Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4.  Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.  Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells.  Essential for correct mitosis, and negatively regulates cell proliferation.
What are the official names of this protein?
DIS3-like exonuclease 2, hDIS3L2.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, P-body.
Protein: LPQB_MYCTU
Sequence: MERLMRLTILLFLGAVLAGCASVPSTSAPQAIGTVERPVPSNLPKPSPGMDPDVLLREFLKATADPANRHLAARQFLTESASNAWDDAGSALLIDHVVFVETRSAEKVSVTMRADILGSLSDVGVFETAEGQLPDPGPIELVKTSDGWRIDRLPNGVFLDWQQFQETYKRNTLYFADPTGKTVVPDPRYVAVSDRDQLATELVSKLLAGPRPEMARTVRNLLAPPLRLRGPVTRADGGKSGIGRGYGGARVDMEKLSTTDPHSRQLLAAQIIWTLARADIRGPYVINADGAPLEDRFAEGWTTSDVAATDPGVADGAAAGLHALVNGSLVAMDAQRVTPVPGAFGRMPEQTAAAVSRSGRQVASVVTLGRGAPDEAASLWVGDLGGEAVQSADGHSLSRPSWSLDDAVWVVVDTNVVLRAIQDPASGQPARIPVDSTAVASRFPGAINDLQLSRDGTRAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDAAHPVSYVNLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGWADVPGLMVPGAAPVLPG
What is the function of this protein?
May modulate activity of the MtrAB system in controlling homeostasis of the cell wall and cell division (By similarity).  Partially restores antibiotic resistance to M. smegmatis in which this gene has been disrupted.
What are the official names of this protein?
Lipoprotein LpqB.
What is the protein family that this protein belongs to?
Belongs to the LpqB lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Secreted, cell wall.
Protein: RL10_RICPR
Sequence: MLRSEKPVAVEDIVNIYKESPSVIITHYHGLTVSQVSSLREELKSKEAGFKVVKNTLAKIAAKQTGLDSITNLFAGPTAIVYSKEPVEMARLVVNFANSNDNLKIIGGIVDNHILDAYSIKELSKLPSLHELRGKIVGLLQAPATKVVGVLQATSSSIARVIHAHAIKH
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: BIOB_SHEON
Sequence: MSQLQVRHDWKREEIEALFALPMNDLLFKAHSIHREEYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLLAMETVLTEARSAKAAGASRFCMGAAWRNPKDKDMPYLKQMVQEVKALGMETCMTLGMLSAEQANELAEAGLDYYNHNLDTSPEYYGDVITTRTYQNRLDTLSHVRASGMKVCSGGIVGMGEKATDRAGLLQQLANLPQHPDSVPINMLVKVAGTPFEKLDDLDPLEFVRTIAVARILMPLSRVRLSAGRENMSDELQAMCFFAGANSIFYGCKLLTTPNPEESDDMGLFRRLGLRPEQGAAASIDDEQAVLAKAAAYQDKASAQFYDAAAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: UGNO_METMP
Sequence: MLKVAVVGIGVMGYNHARIYNELQKDGNVELVGLSDMNKDRLNEVSEEFGVKAFSNYMDLLEEDLDAVSIVVPTFLHKEVALPFIKKGISVLIEKPIADTIENANEIIAEAEKNNVILSVGHVERFNPAVLKLKEHVEKGNLGDIVTMTAKRVGPMTTRIADAGVILDLAVHDIDVMAFLANSKVKHVHALAKNVKHPNNNAEDYALIISSFENSIDGIIEVNRLTPHKTRTLNIVGTKGIAYLDYMNQDLTLYDEEWVKTAKINKEEPLKKEIAHFVDCVQNNKQPLVTGLDGLNALETAIYALKSSNGN
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of UDP-GlcNAc.  Highly specific for UDP-GlcNAc, does not catalyze the oxidation of the substrate analogs UDP-Glc, UDP-GalNAc, N-acetylglucosamine and glucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 3-dehydrogenase, UDP-GlcNAc oxidoreductase, UDP-N-acetyl-alpha-D-glucosamine:NAD(+) 3-oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: ENV_QRFVE
Sequence: MFMVALSLLLLRLSTASPCTSEACSGPYRISKYKMPTIDVSNHKTHVTVWKGPKEVTGILGYRSRYTAYCYEGGVLDGNTGCTKWHVMFPPSAAELQKWAIDGKCYYGVECNKGGDCWGSWADRCHDDRVDLNSAQEKEYNGNNDEWRMFAHHTCISTWRCGFSKSSYPIHFTNVKKGRGDGDITYTLATYDQHGSILSLDKPSVKIDQETTLSFELPRSLVSRSSTEIDCFFGNDQTPVCQLNEHFEDLEGQFVTFNGDYTATYGNYLLALNDKKAINGSVGAKKFGNKAWVEKQLGKAASLEDVRNILSIQMWSHQESGYNLVQLYKVVGEMMNTLTTVINSVGKLDDELIGRLIGVEGKSKWFNSELFHMCPCFQLGSFGDSNCASGYIFSEGRVKVDKDGSKCTSFGGSITPLYLFDNVSYKFAVLHTPPAQGVAQDWEGWSWLAAEKQRLIETMTFQDSVSGGNNVLSQLYKETLDSFNIWKWFERFSTLAAWGALAISVINMMRK
What is the function of this protein?
Attaches the virus to host cellular receptor and later induces fusion of virion with host membrane.
What are the official names of this protein?
Envelope glycoprotein.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein.
Protein: ROK1_CRYNB
Sequence: MASAFSLLTAGGAKFDKNRFKDDFQLFEAKKRKDRKGKSKQIDALAAGSALPSSLDFFGDHPHPQHKPEPEPESESESDFESDSGSSSTSIPAPPPQKITLTGSEPLPKSLHTNLPSLVNHESHSLTSAEGGPLLSALSRANIHSLWGVQCAVGGCLLEDRDTLCVAPTGSGKTLSYVLPTIVKLREPARKLKGTEEGKGVRALVVVPTHDLAVQIQGVIKAVTMGRHWRSMVLTKATEKAVWESAPGEAVKTGEDGDSEMKDGEDSGDEEEDEDDNESTGSVDEFAPKVSGNPEGLGIDVLVATPERLHHLIDSRRISLARTKYVILDESDRLLSSDFLPQVEPILSACSNPAVQKCFLSATMPAGAESLAKKWLKDGGVRVVVGVKDSAVTTVDQSLLYTGSESGKLLALRNLISSGQLPYPSLIFVQSIDRAEELYKTLVLDGIKVDAVHGGKAKTKRDEAIKDFRVGAVWMLVVTEVLARGMDFRGVKVVINYDFPQTVPSYIHRIGRTGRAGRPGKAITFFNIEDGPYLRTIANVLRSSGCPVPEYMLDMKKPTKNEKKKLAKAPPKRKAVGGGGRDLNREAGKKKKQMVEASKKRKMLERKGKGGNEEKNDDEE
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase ROK1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: YJEO_ECOLI
Sequence: MSARMFVLCCIWFIVAFLWITITSALDKEWMIDGRGINNVCDVLMYLEEDDTRDVGVIMTLPLFFPFLWFALWRKKRGWFMYATALAIFGYWLWQFFLRYQFCL
What are the official names of this protein?
Inner membrane protein YjeO.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CBPM_SALG2
Sequence: MANITVTFTITEFCLHTGVTEEELNEIVGLGVIEPYEDDNADWQFDDRAASVVQRALRLREELALDWPGIAVALTLLEENSRLREENRLLLQRLSRFISHP
What is the function of this protein?
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA.  Together with CbpA, modulates the activity of the DnaK chaperone system.  Does not inhibit the co-chaperone activity of DnaJ.
What are the official names of this protein?
Chaperone modulatory protein CbpM.
What is the protein family that this protein belongs to?
Belongs to the CbpM family.
Protein: SCG3_BOVIN
Sequence: MGFLWTGTWIVVLMLHSSPIQAFPKPAGSQDKPLHNRELSAERPLNEQIAEAEADEIKKTYPPENKPGESNYSFVDNLNLLKAITEKEKNEKERQSVKISPNDNKLNVEDVDSTKNRRLIDDYDSTKSGLDRKFQDDPDGLHQLDGTPLTAEDIVQKIATRIYEENDRGVFDRIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEELNKPTSKTESQTGKIPEKVTPMAAIQDAFTNGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDETIALQTKNKLEKNVTDNKSKLFAVPSEKSHEETDSTKEEAAKMEKEYGTLKDSTKDDDSNPRGKTDEHKGKTEAYLEAIRKNIDWLKKHNKKENKEDYDLSKMRDFINQQADAYVEKGILDKEEADAIKRIYSSL
What is the function of this protein?
Member of the granin protein family that regulates the biogenesis of secretory granules (By similarity).  Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity).  May also play a role in angiogenesis.  Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity).
What are the official names of this protein?
Secretogranin-3, Secretogranin III, SgIII.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol- enriched lipid rafts.
Protein: ATP22_YEAS6
Sequence: MLKCICRVYSQPLAQMVTSPLFKHMGSAGTYTILPITNLRHLSTKNCPLKIKSNRSEPLQFGDFERQVPCSRKSGSSKNVQKRLYELRQLKTVLSETFGVTEYASFFESLRNALHINNCSENEKKKLLYDIILHQHELYPEVARKIGFYLPGEVHRWFWYRIPKSESFNHYLFLLKSDVLLFTSNYCTRFTNRLIKGTEMERQLATFQIFLHDETNIKFIMEKVLKLHTFDSLIALVNGLVKAKNFRFIKVFIQALLQKLEQHCYSGKDGAKQKNLRYVKFNNTLLYYLLKSGNVELFIKTFQEELKFIVSSGLLNHIDGNEHILNFPIHHYLNLLRISNRQEELFNVISCLQSSPLMKYKLFKEFLMGELIASFQAFRDPKLVCKYLLSSYSSKASANILNALGIWGWLYHSKSTTLTAPTLARELKNKNNILPNTMRIGSPVTVPILTELYRSLLSSSSVSLESGQFKNCLLDLYYKYKSFLSEEAHKYRYWRNDTGILNVFLNYIRFQAREPRLAYNVLLDFYSQPFAKKVVLTTTLCPFSIVAYKNHTLTQAELSELLQVMHKNGVPLTFKFCSAMVMHYVKMRDEKGARSWYNKILFGGFEIRHMALIQIIKDQGWPFPKNFDETLLTELVENNNIKEPTDSTLFTDEDMFEEDGKPRFNDDDVNKCTNIIRETLKSLN
What is the function of this protein?
Translation factor specific for subunit 6 of the mitochondrial ATPase.  Required for assembly of the CF(0) component of the ATPase (By similarity).
What are the official names of this protein?
Mitochondrial translation factor ATP22.
What is the protein family that this protein belongs to?
Belongs to the ATP22 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ETFB_BACSU
Sequence: MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEAIQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLYHYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVEGDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKLKTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI
What is the function of this protein?
The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases.  It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
What are the official names of this protein?
Electron transfer flavoprotein subunit beta, Beta-ETF, Electron transfer flavoprotein small subunit, ETFSS.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: YFCN_ECOLI
Sequence: MKKKTTLSEEDQALFRQLMAGTRKIKQDTIVHRPQRKKISEVPVKRLIQEQADASHYFSDEFQPLLNTEGPVKYVRPDVSHFEAKKLRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHVFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWLPPELP
What are the official names of this protein?
UPF0115 protein YfcN.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: DER_STRPJ
Sequence: MALPTIAIVGRPNVGKSTLFNRIAGERISIVEDVEGVTRDRIYATGEWLNRSFSMIDTGGIDDVDAPFMEQIKHQAEIAMEEADVIVFVVSGKEGITDADEYVARKLYKTHKPVILAVNKVDNPEMRNDIYDFYALGLGEPLPISSVHGIGTGDVLDAIVENLPNEYEEENPDVIKFSLIGRPNVGKSSLINAILGEDRVIASPVAGTTRDAIDTHFTDTDGQEFTMIDTAGMRKSGKVYENTEKYSVMRAMRAIDRSDVVLMVINAEEGIREYDKRIAGFAHEAGKGMIIVVNKWDTLEKDNHTMKNWEEDIREQFQYLPYAPIIFVSALTKQRLHKLPEMIKQISESQNTRIPSAVLNDVIMDAIAINPTPTDKGKRLKIFYATQVATKPPTFVIFVNEEELMHFSYLRFLENQIRKAFVFEGTPIHLIARKRK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: METK_FRAP2
Sequence: MSKNYLFTSESVSEGHPDKLADQISDAILDEILKQDKNARVACETLVKTGMALVAGEITTSAWIDIEELVRKVIVETGYDNANKGIDGRTCSVINAIGKQSSDIAQGVDRGSLEDLGAGDQGLMFGFATNETPTLMPSAIYYSHLLMRKQAEHRKSGKLGWLRPDAKAQVTLAYENDKPKFIDTIVLSTQHNESISQKDLHDAVIEEIVKEVIPAELITKDTKYHINPTGVFLIGGPQGDCGLTGRKIIVDTYGGAAHHGGGAFSGKDPSKVDRSGAYMGRYIAKNVVAAGLADKCEVQVAYAIGVAKPVSLMVNTFGTGKISDSKIEKLVSETFDLRVGKIIENLDLLRPIYRKTSNYGHFGRELPEFTWEKIDKADNLKSAAKI
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIA_CUPMC
Sequence: MSHPSTAPAHPSRLALYARLVRIDKPIGTLLLLWPTLWAMWMAAGGPPGWTLFWIFFAGTFLMRSAGCAMNDWADRDFDKHVKRTKERPLTAGLIASWEALAVAAVLALIALALILPLNALTKWLAVVAAVLAGTYPFFKRFFAIPQAYLGIAFGFGIPMAFAAIQDQVPFVAWLMLLANVFWAIAYDTAYAMVDRDDDLLLGMKTSAITFGRFDVAAIMICYAVFLGLMAWAGSLLGLGWPYYAGLVAAAGMAGYHYTLIRERDRMKCFAAFRHNNWLGACVFAGTFVAYLLK
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RMC1_HUMAN
Sequence: MGEEDYYLELCERPVQFEKANPVNCVFFDEANKQVFAVRSGGATGVVVKGPDDRNPISFRMDDKGEVKCIKFSLENKILAVQRTSKTVDFCNFIPDNSQLEYTQECKTKNANILGFCWTSSTEIVFITDQGIEFYQVLPEKRSLKLLKSHNLNVNWYMYCPESAVILLSTTVLENVLQPFHFRAGTMSKLPKFEIELPAAPKSTKPSLSERDIAMATIYGQLYVLFLRHHSRTSNSTGAEVVLYHLPREGACKKMHILKLNRTGKFALNVVDNLVVVHHQDTETSVIFDIKLRGEFDGSVTFHHPVLPARSIQPYQIPITGPAAVTSQSPVPCKLYSSSWIVFQPDIIISASQGYLWNLQVKLEPIVNLLPDKGRLMDFLLQRKECKMVILSVCSQMLSESDRASLPVIATVFDKLNHEYKKYLDAEQSYAMAVEAGQSRSSPLLKRPVRTQAVLDQSDVYTHVLSAFVEKKEMPHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDMLKRLSTANDEIVEVLLSKHQVLAALRFIRGIGGHDNISARKFLDAAKQTEDNMLFYTIFRFFEQRNQRLRGSPNFTPGEHCEEHVAFFKQIFGDQALMRPTTF
What is the function of this protein?
Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF).  Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162).
What are the official names of this protein?
Regulator of MON1-CCZ1 complex, Colon cancer-associated protein Mic1, Mic-1, WD repeat-containing protein 98.
What is the protein family that this protein belongs to?
Belongs to the RMC1 family.
What are the subcellular locations of this protein?
Lysosome membrane. Late endosome membrane.
Protein: PNP_STRPI
Sequence: MAKQVFQTTFAGRELIVETGQVAKQANGSVVVRYGESTVLTAAVMSKKMATGDFFPLQVNYEEKMYAAGKFPGGFMKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFDGPIAGVQVGYVDGQIIINPSQEQAEQSLLELTVAGTKHAINMVESGAKELSEEIMLEALLKGHEAVKELIAFQEEIVAAVGKEKAEVELLHVDADLQAEIIAAYNSDLQKAVQVEEKLAREAATQTVKDQVIAVYEEKYADHEEFDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRKVDEIRPLDAVVDFLPRVHGSGLFTRGQTQALSVLTLAPMGETQIIDGLDPEYKKRFMHHYNFPQYSVGETGRYGAPGRREIGHGALGERALAQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGNNYTVLTDIQGLEDHFGDMDFKVAGTRDGITALQMDIKIQGITAEILTEALAQAKKARFEILDVIEATIPEVRPELAPTAPKIDTIKIDVDKIKIVIGKGGETIDKIIAETGVKIDIDEEGNVSIYSSDQDAINRAKEIIAGLVREAKVDEVYRAKVVRIEKFGAFVNLFDKTDALVHISEMAWTRTNNVEDLVAIGDEVDVKVIKIDEKGRVDASMKALLPRPPKPERDEKGEKSERPYRPRHHKDHKPKKEITETPKDSE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y399_WOLSU
Sequence: MEERFYQFLRGHHVLHLATLGEQGLWCAPLFYALDEERIEFVVASDPKTRHTQGALQEPRIAGSVALETKSVGLIQGLQFEGIWKSEDPKARELYFKTFPLARALFPVLWRIEILHAKLTDNRLGFGKKLEFFRENHSL
What are the official names of this protein?
UPF0306 protein WS0399.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: ISPH_HYPNA
Sequence: MTTKPPLTLRLAAPRGFCAGVDRAIQIVEEALKKWGAPVYVRHEIVHNRHVVERLEALGAIFVEELEECPDDRPVIFSAHGVPKSVPAEAGRRNMIYVDATCPLVSKVHVEAERHFNAAREIVLIGHAGHPEVIGTMGQLPEGSVALIETVEDARAFQPRDHANLAFITQTTLSVDDTADIVAALQSRFPGIATPHKEDICYATTNRQEAVKVFAPGAELVLVIGARTSSNSVRLVEVALRAGAQDAKLIASADDIDWSWFNGITTLGLTAGASAPEDLVQGVIEACRDRFEVTVETVKTADETVTFKLPRVLAG
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: VKT4_PSETT
Sequence: MSSGGLLLLLGLLTLWEVLTPVSSKDHPKFCELPADTGSCKGNVPRFYYNADHHQCLKFIYGGCGGNANNFKTIEECKSTCAA
What is the function of this protein?
Serine protease inhibitor (By similarity).  Does not inhibit plasmin, and does not reduce blood loss in the mouse tail vein blood loss model.
What are the official names of this protein?
Kunitz-type serine protease inhibitor textilinin-4, Txln-4.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: ENO_HAEIN
Sequence: MAKIVKVIGREIIDSRGNPTVEAEVHLXGGFVGLAAAPSGASTGSREALELRDGDKSRFLGKGVLKAVAAVNNEIAQAIVGKDATNQAEIDQIMIDLDGTENKSNFGANAILAVSLANAKAAAASKGLPLYAYIAELNGTAGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLREALRIGAEVFHNLAKVLKAKGMSTAVGDEGGFAPNLASNADALACIKEAVEKAGYVLGKDVTLAMDCASSEFYNKENGMYEMKGEGKSFTSQEFTHYLEELCKEYPIVSIEDGQDESDWEGFAYQTKVLGDRVQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRIAKYNQLIRIEEALERAGTPAAFPGLKAVKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: AROA_STRS2
Sequence: MKLRRSVEKLKGTIRVPGDKSISHRSIIFGSLAKGVTRFHNILRGEDVLSTMQVFRDLGVKIEDNGDIVEVHGVGFDGLQAPKNDLDMGNSGTSIRLISGVLAGQDFEATMFGDDSLSKRPMDRVTIPLSQMGLKISGQTERDLPPLTIKGNKNLKPIRYQLPVASAQVKSALIFAALQAEGNSVIVKKDLTRNHTEDMIVQFGGQLKFNGKEIRIQGGQEFIAQEITVPGDISSAAFWLVAGLIIPGSKIVLENVGINETRTGILDVIKAMGGKMTLSNIDELAKSATITVETSELKATEIAGELIPRLIDELPIITLLATQAHGTTIICDAEELKVKETDCIQVVADALNSMGATIEPTEDGMIIHGPTALHGAEINTFGDHRIGMMTAIAALLAKDGEVVLERAEAINTSYPAFFEHLNSLMD
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.