PharMolix/UniProtQA huggingface dataset:
Protein: FMT_CHLAD
Sequence: MRIIFLGSPSYAVHALDALVAAGYTIVGVVTQPDRPAGRDRRLTPPPVKVAALAHGLPVLQPETLRDPEVVETLRALQPDVGVVAAYGEILRRAVLEIPPLGYLNIHPSLLPLYRGPTPVAGAILAGETVTGVTIMRLDPGMDSGPILAQAMVDLPPNARTGPLTDELFRLGATLLVEVLPRYARGEIELRPQDHSQATVTKMLKKEDGRIDWTLPAIVIERMTRAYDPWPSAYTFWRGQMLRIMSAAVAPTDASATPGMVIGRSAHGHPLVQTGSDALELVEVQPASRRPMSGAAWLAGVHAPEITLG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: MIAB_ECO24
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLDATHGYQLTDVAEEADVLLLNTCSIREKAQEKVFHQLGRWKLLKEKNPDLIIGVGGCVASQEGEHIRQRAHYVDIIFGPQTLHRLPEMINSVRGDRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDILFEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGSFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRILNLMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETTEDFEKTMKLIADVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGTPDMIGKFVDVEITDVYPNSLRGKVVRTEDEMGLRVAETPESVIARTRKENDLGVGYYQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_XYLFA
Sequence: MSEDRPSRSGDGNKILYCSFCGKSQREVRKLIAGPSVFICDECVELCNDIIREELEEKSQSARSSLPKPKEILEVLDQYVIGQQRAKRTLAVAVYNHYKRIESRHKNDDIELAKSNILLVGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVERAQHGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTKNILFICGGAFAGLDKVIQQRCTEAGGIGFGVKVKSSESKRDVGKVLAGVEPEDLIKFGLIPEFVGRLPVVATLDELDESALVKILTEPKNAITKQFKKLFEMENVELEFRQDALSAVARKALKRKTGARGLRTIVELVLLDTMYELPSQEGISKVVVDESVIENKSEPYLIYQTMPAKVASGE
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: YL088_MIMIV
Sequence: MATVGEYDVDGEFPCYTYEYSKGFTKLMYLIITEKNNPNGHKNIVSYLSDKKNVKSINQKNKKGYTALSIAVRNCGNWCSYKTVRILLEKGAKTNIKNNEGITPLIFASFNSRFCEGFNVINLLLKYGADINARDNNGYTALMNASSNSNSSSTYTTVKLLLDNDANIDDKDKNGLTCLMHACNNVTLKSSIGTIELLLYYGADINAVDNNGRTALMHACDNSNNIELIELLLNRGADIEAVDYKGLTCLMIASKYAGSINSVEVVEILINRGANIEARNEKLRTPLMYACKYSHNNTSVIKLLLDKGANIETTDLRNNTALILASTYSSSVEPIKLLLDKGANINHTNDEGCNALNLACINSSYNNNSEIVKLLIDRGSNINNMDSERTILTSTCEFIGKGSNIDTVKILLDNNADPNIPNTNGNTTLLYMCKKYIKDGPKKRDLNFNVIKLLLDYKANPNFINKKNENSLTRLSKYSDKVDIEIIKLLLDYGVDINSTNNYCNSALLLFCMDLQNSCTKISYNCKNIVKLLLEKGADVNIINSNGNTALSIICESDDNNLSDIIELLLAHNANPNTINKEEYTPLMHLIERFDYFLTNSKSIPQNIESDSDSDSMSGFESYRGFSQSSKSVNKYNLDKIEKNKNEPEINYRQKNLEMLLKHKTTKINFQNSSGITALLHECQVSDNIEPIKLLLDNGADPNIQDEKGETALHKAVRHTNKIDVIKLLMDYHANPYIFRNKGQDLLSYAFKKSSRRNFVNIAKNLINNPCHVLSDENRSQIFESKDKENIISIIKMLEYNAKIKAKFDVTIDLMPQIATQIIYNHKSLRARLLKLKWLYMCGDIDKIITLENFELFDYLCVENMYQLHDKIIGISDHI
What are the official names of this protein?
Putative ankyrin repeat protein L88.
Protein: ATP6_STRPM
Sequence: MEEAKIPMLKLGPITFNLTLLAVCIVTIAVIFAFVFWASRQMKLKPEGKQTALEYLISFVDGIGEEHLDHNLQKSYSLLLFTIFLFVAVANNLGLFTKLETVNGYNLWTSPTANLAFDLALSLFITLMVHIEGVRRRGLVAHLKRLATPWPMTPMNLLEEFTNFLSLAIRLFGNIFAGEVVTGLIVQLANYRVYWWPIAFLVNMAWTAFSVFISCIQAFVFTKLTATYLGKKVNESEE
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRM9B_BOVIN
Sequence: MDHAAAQLEKQHVHDVYESTAPYFSDLQSKAWPRVRQFLQEQKPGSLIADIGCGTGKYLKVNSQVHTLGCDYCAPLVEIARSRGCEVMVCDNLNLPFRDQGFDAIISIGVIHHFSTKQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRHFEKQDVLVPWNKALCSQRLSESGQPGRKQECGHPERGYPYHPACSACHCSVCFEGRCNSKRSHSVDCDSVLAGTCCANISKEGEEENGFYNTLGKSFRSWFSSRSLDESTLRKQIEKVRPLKSTESWANSAISIQPSRHSSFDLGHPETLSAGEQNLDEEVFVEPSQGPREWLRAPTTCKQLNGDHPGVIRRNGDGNFLGGANAKESCVDEGNLEEGTASGSKLWRRISAADSTDSNPGDAISVEEQQPDVLDSRAFMRYYHVFREGELCGLLKESVSELHILSSGNDHGNWCVIAEKRESCD
What is the function of this protein?
May modifie wobble uridines in specific arginine and glutamic acid tRNAs.  Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity).
What are the official names of this protein?
Probable tRNA methyltransferase 9B, Probable tRNA methyltransferase 9-like protein.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: ASTA_ECO7I
Sequence: MMVIRPVERSDVSALMQLASKTGGGLTSLPANEATLSARIERAIKTWQGELPKSEQGYVFVLEDSETGTVAGICAIEVAVGLNDPWYNYRVGTLVHASKELNVYNALPTLFLSNDHTGSSELCTLFLDPDWRKEGNGYLLSKSRFMFMAAFRDKFNDKVVAEMRGVIDEHGYSPFWQSLGKRFFSMDFSRADFLCGTGQKAFIAELMPKHPIYTHFLSQEAQDVIGQVHPQTAPARAVLEKEGFRYRNYIDIFDGGPTLECDIDRVRAIRKSRLVEVAEGQPAQGDFPACLVANENYHHFRVVLVRTDPATERLILTAAQLDALKCHAGDRVRLVRLCAEEKTA
What is the function of this protein?
Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.
What are the official names of this protein?
Arginine N-succinyltransferase, AST, AOST.
What is the protein family that this protein belongs to?
Belongs to the arginine N-succinyltransferase family.
Protein: COG6_DICDI
Sequence: MNSTLSRKIQKVLDIKLDSEDLSNALEELSTFYTSNSIGARRNLRNEIEKRYLDINIQFLDQFDQLNKNINELVLDFEGIKNSCVDICDHLNSTNRVSSELLKNAHELSCGLKEIKEKENTLQQFFKKFKLTPQEEQSLVKKEIDSSFYQTLDRLSEIQNECKKNLLSNQYQKPTYEILEIITKHQDNAYRRLYQWTKEEIKQLLIIEIPILDSFNNIDQQQQQQQQKVMMLPIALSALQNKPLLFKHCLDEISECRTKTISNGFITALSFGGPNGIPRPIEINAHDPQRYLGDMLAWIHQCLASEFELISTILSKVTIKLNENNNNNVDDNIENNNNNNNNNEELNFIEPIIKVLNNSFECINRPLSIRIDQILQSKPGVIITYKMISLLDFYSRMANLITKGSGVCRVSTIFGSIKSNCLSVFFTQIKDNFDRLERSPTVPSPQDLLPTNDIKDSINKLSELISTFNSSLIPLDEREKEYTPVFSSFIQKIINLTTFSATSSKLPLISMAVFMINCLSSIKSVLENYTSFTASNLELLTCQIEAHMDTLVEEQTSELLQQMGIGPKLSILQYSDNKSPLSQIIAMDRLSIVQSIRQFDNCLEQSFGTLLMPNCEKLSDTTLRSLSKKSVSNLISVAYSSLYSAIHDPFNQYDEPNSIFQYKPDQIKTMLDF
What is the function of this protein?
Required for normal Golgi function.
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 6, COG complex subunit 6, Component of oligomeric Golgi complex 6.
What is the protein family that this protein belongs to?
Belongs to the COG6 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: DAPB_ALKOO
Sequence: MDLLIYGVNGHMGSLIKNLAEKDSYWRVIGGVDSEMSDDPMNNRYDVVVDFSHPSALQDVLQLCKEKKIPLVIGTTGFSKEQLEDIKFASAKIPILQSTNMSLGMNLLFRLVEQTAAVLKDKSDIEVIESHHNRKKDAPSGSARTIVESIEKGLGEEKKHQHGRVGECPREKGEIGIHAIRGGNIVGYHEANFINDLETIKIVHEAHNRSVFAQGALDAAKFIMDQEPGLYTMKDLLNLMV
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQIB_CAEEL
Sequence: MEPVISPTLDSKQSWSIFILDHEESLASPRKLNIPNPENVYSENRRYFADQDFRRPRHKPDQNMVEYWVPPEKTSVAKNNTTGQAVTPGQAKKLNQVCPASAPNGKRAMKIPKVKEPRGENSSKKSSADQAPGPFRVMYWKVGQYFEKASGTVNHHYQKVVLFRNRMKANKVAPIHTKVQSRHLELEPLCCLSSCLVRGGCTTVVVFELCYVVATALCIFEAMFRKKFALWEPFPKSFNGWFAHPLFYYTIAVYDVALFVIAIATARALVNFDKAVLHIHYIFCIFSFFINFFFLIFSIWSLVSPGSLTFTPINCLLIFCFLYQLPLNIWGFFVVKSCRDFFALIHVFVSLAEA
What are the official names of this protein?
Uncharacterized protein C45G9.11.
Protein: YBEY_SALNS
Sequence: MSQVILDLQLACENHAGLPDEAQFQRWLDGVIPQFQEEAEVTIRLVDEAESHDLNLTYRGKDKPTNVLSFPFEAPPGIEMPLLGDLIICRQVVEQEAQEQSKPLEAHWAHMVVHGSLHLLGYDHIDDDEAEEMESLETEIMLAMGYEDPYIAEKIAE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAZA2_FELCA
Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: DAPF_ARATH
Sequence: MEIAAVSTVSVAPQSRRVSNAFSRNLGSVSSLSFGFFEKEYCFKSPSLRVSAAASMDAVTAEKFSPASFLDKKETGVLHFVKYHGLGNDFILVDNRDSSEPKITQEQAAKLCDRNFGVGADGVIFAMPGVNGTDYAMRIFNSDGSEPEMCGNGVRCFARFIAELENLQGKHSFTIHTGAGLIVPEIQDDGQVKVDMGTPILKAQDVPTKLSGNKGEAVVEAELVVDGVSWNVTCVSMGNPHCITFGKKGGPNLKVDDLNLPEIGPKFEHHEMFPARTNTEFVEVLSRSHLKMRVWERGAGATLACGTGACALVVAAVLEGRADRKCTVDLPGGPLEIEWKQEDNHIYMTGPAEAVFYGSALL
What is the function of this protein?
Racemase that operates by a 'two-base' mechanism, which involves one active-site cysteine acting as a base to abstract the alpha-proton of an amino acid, while a second cysteine thiol functions as an acid to reprotonate the resulting planar carbanionic intermediate from the opposite face.
What are the official names of this protein?
Diaminopimelate epimerase, chloroplastic, DAP epimerase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL7A_PYRAE
Sequence: MAVTIDPKTFYANPPPGKPFYVRFEVPNDVAEKALEILSIARQTGKIKKGTNETTKAVERGLAKLVLIAEDVDPPEVVAHLPLLCEEKKVPYVYVPSKEKLGKAAGINVSAAAAVVIEPGQAAGELEALVSKINEVRAKHGLNAIPVPAKR
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYOE_ECOSM
Sequence: MMFKQYLQVTKPGIIFGNLISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPAVSLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGEFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLSLGGYAGYKYLVVAAAVSVWWLGMALRGYKVADDRIWARKLFGFSIIAITALSVMMSVDFMVPDSHTLLAAVW
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UVRC_DESPS
Sequence: MPMFPEKILQSTPHKPGVYLMLDAKARVIYVGKAKDLVKRLTSYTRHSSSEHNKTTVMLKKVEQVKTIITTTEKEALILEASLIKKHKPRYNIILRDDKNYPYIAVTVGEEWPRVMMVRRKRRDNSRYFGPYSSATAMWATLKLIASLFPLRNCRGEKLRPRTRPCLNRQIGKCLAPCTGNVSRKIYMENVDKILLLLQGKSRDLLAELKRQMLQASERLNFEQAGQFRDQIRALKTTLEKQLVAAGHGKNQDVFGYVRSGTTVAVNILFVRDGLVSGSRSFFIEDYFGLDSQVLSQTISQYYDRETPPPKEILLPFSPENFELLSEYLADFTTHILQIKIPQRGDSTILVEMANTNARQLFAEKEKKERSWQSLGKSIKEKLQLSRTPETIECLDISNISGQHAIGSLVCFSGGEANKSRFRHYKIRTIEGPDDYGMMREVMERRFKRGIKEGNLPNLFVVDGGKGQLGMAMAVARELGITNELDWIGIAKERHEEGEKLYKPGRKNPILLPAHSPVLLYLMRIRDESHRYGITFHRKLRNRATLSSELDEIEGIGDNRKKLLLKKIGSLKKIKEASLQKLQEVEGIGPLLAKKIYTSLQRDKNKS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PNP_WOLWR
Sequence: MFKIIKKSIEWGGRTLSLETGKIARQAHGSVVVNYGDTSVLVTVVSKKKEENVDFLPLNVQFIAKSYAMGKIPGGFFKREGKPSDRETLISRVIDRSIRPLFPEGFHDEISVVCNLLTYDTVNPPEVPALIGAVAALAISGVPFHFTIAGVMVGCDENNNYILNPSVQEMKASSLDLFLSGDENSILMVESEVKELSEENVFNAIKFGHEHLKPVIKLIKEFADTIGNKPESFAPIDASDITQELEKYGKDFEKAYSQTVKQERVQALEAIRENILNTLKETGKDEKLITYAVKNFERSLVREIIRKKSVRIDGRKHDEIRQIEVEVDILSKTHGSALFTRGNTQALVVTALGTTQDEQIVDDIEGDRREHFMLHYNFPSFAVGETSAARAPGRREIGHGKLAWKAIHPVLPDKSEFPYTIRVVSEILESDGSSSMATVCGTSLALMDTGVPIKAPVAGIAMGLIKDKDEYVILSDILGDEDYLGDMDFKVAGTSEGVTALQMDMKISGISFEIVEKSLEQAKAGRLHILEKMNAVISEHSDDVKDHAPRMLSFYIDKDKISAAIGSKGKNIRSVCERSNAKIEIGDDGKVSVFATSGTEAEIAKSMMIDSITELEQGSIVDVKVVRIEKSIVELEFLNGRKGKMHISEVANEHIDSIESVLKQDDTFKALVIDFEKGGCPKLSRRRVDQETGEFFEGELYNEERKDGPNDRDNYYNNSFSRKPGGSHHKRPPRPRSGFSNRNRPKFGNNDSSSGFY
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHR54_CAEEL
Sequence: MEIPSTSSEMTYFSVKCAICYKAGHGQHFGVETCRACAAFFRRTVVLNRKYKCTRKSGKCKIGSDETKDVMCKFCRFKKCIDLGMTTENVRTDQVINLNVEPSTSQSLVRLEMTSLQPETDDSNRVQYQIIHPRTRGPAILIDVNAIIKRSKTILETHFFPDDDVIVELNPLEKMTFCLRKLRSKQSWNPNFFTKINFLDLFEFWESQMEDTATWLMYSGEFRKLPNHEKIAIFKIVWAVWRRLERYTMTAQVFGQKCYDEQILLHSHQDAARFTDYDVDYSYITDQGFEKINGLFGGKMIQYFDIIVKPYLELELSDTEIAYILCQIVWNYAGRRLQGQTQAAGERFLEVISNNLHKYYEDKSGNRKRAEDKQNYVARLAKMMQIVNQMLNAQLKMENTMDVAMLFNTFNIVFTEPEFFRV
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-54.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEU1_PARD8
Sequence: MSDRLFIFDTTLRDGEQVPGCQLNTVEKIQVAKALEQLGVDVIEAGFPVSSPGDFKSVVEISKAVTWPTICALTRAVEKDIDVAAEALRFAKRGRIHTGIGTSDSHIKYKFNSTREEIIERAIAATKYAKKYVEDVEFYCEDAGRTDNEYLARVVEAVIKAGATVVNIPDTTGYCLPDEYGAKIKYLMEHVDGVHNAILSTHCHNDLGMATANTVQGVLNGARQVEVTINGIGERAGNTSLEEVAMVFKSHKERDIITNITTNKIYSTSRMVSSLMNMPVQPNKAIVGRNAFAHSSGIHQDGVLKNAQTYEIIDPKDVGIDDNAIVLTARSGRAALKHRLHVLGVDLEQEKLDKVYDEFLKLADRKKDINDDDVLMLVGKDRTATHRIKLEYLQVTSGVGVQSVASICLNLSGVRRYEAAAGNGPVDAGIKAVKKAISNSDMTIQEFLIQAINKGSDDTGKVHMQVEYNGATYYGFSANTDIIAASVEAFVDAINKFIVD
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: NORR_ECO57
Sequence: MSFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLAKDVLGRRFALEGHPRLEAIARAGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNALLIEQLESQNMLPGDAAPFEAVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLVYLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRERGDDVILLAGYFCEQCRLRQGLSRVVLSAGARNLLQHYSFPGNVRELEHAIHRAVVLARATRSGDEVILEAQHFAFPEVTLPPPEVAAVPVVKQNLREATEAFQRETIRQALAQNHHNWAACARMLETDVANLHRLAKRLGLKD
What is the function of this protein?
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon.  Activation also requires sigma-54.
What are the official names of this protein?
Anaerobic nitric oxide reductase transcription regulator NorR.
Protein: MRP1_MOUSE
Sequence: MALRSFCSADGSDPLWDWNVTWHTSNPDFTKCFQNTVLTWVPCFYLWSCFPLYFFYLSRHDRGYIQMTHLNKTKTALGFFLWIICWADLFYSFWERSQGVLRAPVLLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALLCALAILRSKIISALKKDAHVDVFRDSTFYLYFTLVLVQLVLSCFSDCSPLFSETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLSNSSSHSGDTSQQHSSIAELQKAGAKEETWKLMEADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRNFRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYSMAKDAGLV
What is the function of this protein?
Mediates export of organic anions and drugs from the cytoplasm.  Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics.  Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595, PubMed:9359705).  Hydrolyzes ATP with low efficiency.  Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity).  Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (PubMed:9359705).  Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export (PubMed:36070769).  Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway (PubMed:36070769).
What are the official names of this protein?
Multidrug resistance-associated protein 1, ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, LTC4 transporter.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UTS2_POLSP
Sequence: GSTSECFWKYCV
What is the function of this protein?
Has a suggested role in osmoregulation and as a corticotropin-releasing factor.  Probably involved in smooth muscle stimulation.
What are the official names of this protein?
Urotensin-2, Urotensin II, U-II, UII.
What is the protein family that this protein belongs to?
Belongs to the urotensin-2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RIM2_YEAST
Sequence: MPKKSIEEWEEDAIESVPYLASDEKGSNYKEATQIPLNLKQSEIENHPTVKPWVHFVAGGIGGMAGAVVTCPFDLVKTRLQSDIFLKAYKSQAVNISKGSTRPKSINYVIQAGTHFKETLGIIGNVYKQEGFRSLFKGLGPNLVGVIPARSINFFTYGTTKDMYAKAFNNGQETPMIHLMAAATAGWATATATNPIWLIKTRVQLDKAGKTSVRQYKNSWDCLKSVIRNEGFTGLYKGLSASYLGSVEGILQWLLYEQMKRLIKERSIEKFGYQAEGTKSTSEKVKEWCQRSGSAGLAKFVASIATYPHEVVRTRLRQTPKENGKRKYTGLVQSFKVIIKEEGLFSMYSGLTPHLMRTVPNSIIMFGTWEIVIRLLS
What are the official names of this protein?
Mitochondrial carrier protein RIM2.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL15_PARXL
Sequence: MELNNLKPAEGAKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFTSLTKEFVGEVRLSDLEKLPVDEIDLLALKQAGLVGELIKSAKIIATGELKRKVVVKGLGATKGARAAIEAAGGSFAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: ATPD_PSEP1
Sequence: MAELTTLARPYAKAAFEHAQAHQQLANWSAMLGLAAAVSQDDTMQRLLKAPRLTSAEKAATFIDVCGDKFNAQAQNFIHVAAENDRLLLLPEIAALFDLYKAEQEKSVDVEVTSAFALNQEQQDKLAKVLSARLGQEVRLHASEDASLIGGVVIRAGDLVIDGSVRGKIAKLAEALKS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.