PharMolix/UniProtQA huggingface dataset:
Protein: MYG1_BOVIN
Sequence: MGHRFLRGFLRVLLPPLPLRSPHLKLSLEPVAPSKRPRSHLMAPPRIGTHNGTFHCDEALACALLRLLPEYREAEIVRTRDPEKLAACDIVVDVGGEYDPQRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDGMVGTLYDKMYENFVEEVDAVDNGISQWEEGEPRYLLTTTLSARVARLNPTWNQPNQDTEAGFKRAMDLVREEFLQRLDFYQNSWLPARTLVEEALAKRFQVDPSGEIIELEKGGCPWKEHLYQLELGLSPAGTIAFVIYTDQAGQWRVQCVPKEPHSFQSRLPLLEPWRGLRDEALDQISGIPGCIFVHASGFIGGHRTREGALSMARATLAQRPAPTPAPNPMVQ
What is the function of this protein?
3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion.  Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk.  In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation.  In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins.
What are the official names of this protein?
MYG1 exonuclease.
What is the protein family that this protein belongs to?
Belongs to the MYG1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Mitochondrion matrix. Nucleus, nucleolus.
Protein: MATK_FRECA
Sequence: MEEFQVYLELNRSRRHDFLYPLIFREYIYALAHDHGLNKSMIFLENQGYGNKFSSLIVKRLIIRMDQQNHLIISANDSNQNPFFGHNNNLYSQMISAGFAVIVEIPFSLRLLSYSQGEEVAKSHNLQSIHSIFPFLEDKFSHLNYALDVLIPHPIHLEILVQALRYWVKDASSLHLLRFSLYEYCNLKSFITPKKSISILNPRLFLFLYNSHACEYESIFLFLRNQSSHLRSTSSGVFLERIFFYGKIEYLVEVFYNDFQNNLWLFKDPFIHFIRYQGKAILASKDTSLLMNKWKYYFVDLWQYYFYMWSQSGRVRINQLSKYSLDFLGYLSSVRLNPSVVRSQMLENSFIIDNTMKKLDTRIPIISLIGSLSKAKFCNTLGHPISKPTWADSSDSDIIDRFVRICRNLSHYHSGSSKKKSLYRIKYILRFSCVKTLARKHKSTVRAFLKRLESEFLEEFFTEEEHVFSLIFPRVFFTSRKLYRGRIWYLDIICINALVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SSUD_ECO27
Sequence: MSLNMFWFLPTHGDGHYLGTEEGSRPVDHGYLQQIAQAADRLGYTGVLIPTGRSCEDAWLVAASMIPVTQRLKFLVALRPSVTSPTVAARQAATLDRLSNGRALFNLVTGSDPQELAGDGVFLDHSERYEASAEFTQVWRRLLLGETVNFNGKHIHVRGAKLLFPPIQQPYPPLYFGGSSDVAQELAAEQVDLYLTWGEPPELVKEKIEHVRAKAAAHGRKIRFGIRLHVIVRETNDEAWQAAERLISHLDDETIAKAQAAFARTDSVGQQRMAALHNGKRDNLEISPNLWAGVGLVRGGAGTALVGDGPTVAARINEYAALGIDSFVLSGYPHLEEAYRVGELLFPHLDVAIPEIPQPQPLNPQGEAVANDFIPRKVAQS
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: NIFA_KLEPN
Sequence: MIHKSDSDTTVRRFDLSQQFTAMQRISVVLSRATEASKTLQEVLSVLHNDAFMQHGMICLYDSQQEILSIEALQQTEDQTLPGSTQIRYRPGEGLVGTVLAQGQSLVLPRVADDQRFLDRLSLYDYDLPFIAVPLMGPHSRPIGVLAAHAMARQEERLPACTRFLETVANLIAQTIRLMILPTSAAQAPQQSPRIERPRACTPSRGFGLENMVGKSPAMRQIMDIIRQVSRWDTTVLVRGESGTGKELIANAIHHNSPRAAAAFVKFNCAALPDNLLESELFGHEKGAFTGAVRQRKGRFELADGGTLFLDEIGESSASFQAKLLRILQEGEMERVGGDETLRVNVRIIAATNRHLEEEVRLGHFREDLYYRLNVMPIALPPLRERQEDIAELAHFLVRKIAHSQGRTLRISDGAIRLLMEYSWPGNVRELENCLERSAVLSESGLIDRDVILFNHRDNPPKALASSGPAEDGWLDNSLDERQRLIAALEKAGWVQAKAARLLGMTPRQVAYRIQIMDITMPRL
What is the function of this protein?
Required for activation of most nif operons, which are directly involved in nitrogen fixation.
What are the official names of this protein?
Nif-specific regulatory protein.
Protein: END4_PROA2
Sequence: MRRIGAHVSIAGGIENAPMRAREIGATAFAMFTKNQRQWNAPPLTTQSIDAFKNNCAECGYHARHILPHDSYLINLGSPDPAKLERSRKAFTDEMQRVEALGLSLLNFHPGSHLNETGIDNCLNTIAESVNIALDNSSGVTAVLENTAGQGSNLGHTFEQLAAIIDQIEDKTRVGVCLDTCHLFAAGYDLRTSEAVEATFNEFDSIVSLSYLRGMHLNDAKLDLGSKRDRHESIGSGFIGNDGFAAIIQHPACDEIPLILETPNPDIWNREIEMLYQMEGDKR
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RLME_RHIL3
Sequence: MTKAPIAGNRTGRKLGQRVKNKKMKASSRQWLERHINDPYVQRAQLEGYRARAAFKLLEIDEKHHILRGARRIIDLGAAPGSWSQIAAKVTGSTDDDIRVAAIDFLEMTQLPGVKILQLDFLDPSAPEKLLEAVGGTPDLVISDMAAPTTGHHRTDHLRTMHLCEVAAHFAVEVLGEGGHFLTKTFQGGTERELLAMLKQNFRQVVHVKPNSSRAESVEMFLLAKGFKGRKAEGEAEEA
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCD_PSYA2
Sequence: MSIKSDRWIRKMAEEHGMIEPFEAGQVRFNDAGERLVSYGTSSYGYDVRCAPEFKVFTNVHSVIVDPKNFDEKSFIDIIGDECIIPPNSFALARTMEYFRIPRDVLTICLGKSTYARCGIIVNVTPLEPEWEGHVTLEFSNTTNLPARIYAGEGVAQMLFFQSDADDVCETSYKDRGGKYQGQRGVTLPRT
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: YEZG_BACSH
Sequence: MDTPKMGDLYQRIANQINEMIPSEWENVYLYAEILDDSSEVYFYFNIPGKNEFLYSHNIPEHFNVSEDIYDDLLIELQESFEELREEYEKNNPETWTNLTLKLDRTGQFSIDYNYEDVIASELNGSQRKAVWVYKNLGLMPKRKTVRDFLEDYIKTNEGKI
What is the function of this protein?
Immunity component of an LXG toxin-immunity module.  These modules promote kin selection, mediate competition in biofilms, and drive spatial segregation of different strains, indicating that LXG toxins may help avoid warfare between strains in biofilms.  Neutralizes the toxic abilities of cognate toxin YeeF upon expression in E. coli and in vitro.
What are the official names of this protein?
Immunity protein YezG.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CF1B1_SOYBN
Sequence: MATPASITNVTVEFLQFPALVTPPGSTKSYFLGGAGVRGLNIQEEFVKFTGIGVYLEDKAVSSLAAKWKGKSAAELLDSLDFYRDIIKGPFEKLIRGSKLRTLDGREYVRKVSENCVAHMQSVGTYSDEEEKAIEEFRNAFKDQNFPPGSTVFYKQSPTGTLGLSFSKDETIPEHEHAVIDNKPLSEAVLETMIGEIPVSPALKESLATRFHQFFKELEANPNIEN
What is the function of this protein?
Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones.  Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity).
What are the official names of this protein?
Chalcone--flavanone isomerase 1B-1, Chalcone isomerase 1B-1.
What is the protein family that this protein belongs to?
Belongs to the chalcone isomerase family.
Protein: PBOV1_HUMAN
Sequence: MRAFLRNQKYEDMHNIIHILQIRKLRHRLSNFPRLPGILAPETVLLPFCYKVFRKKEKVKRSQKATEFIDYSIEQSHHAILTPLQTHLTMKGSSMKCSSLSSEAILFTLTLQLTQTLGLECCLLYLSKTIHPQII
What are the official names of this protein?
Prostate and breast cancer overexpressed gene 1 protein, Protein UROC28, UC28.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PETD_STAPU
Sequence: MGVIKKPDLTDPVLRAKLAKGMGHHYYGEPAWPNDLLYMFPVCILGTIACNVGLAVLEPSLIGEPANPFATPLEILPEWYFFPVFQILRVVPNKLLGVLLMASVPVGLITVPFIENVNKFQNPFRRPVATTIFLIGTVVAVWLGIGATLPIDTSLTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: NRDR_ESCF3
Sequence: MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREPFNEEKLRSGMLRALEKRPVSSDDVEMAISHIKSQLRATGEREVPSKMIGNLVMEQLKKLDKVAYIRFASVYRSFEDIKEFGEEIARLED
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: RNZ_BACAC
Sequence: MEFVFLGTGAGVPSKGRNVSAIALQLLEERGQTWLFDCGEATQHQILHTSVRPRRIEKIFITHLHGDHIFGLPGLLGSRSFQGGTTPLTVYGPKGIKQFIEVALSVSTTHVKYPLEIVEITEEGTVFEDNEFHVETKRLSHGIECFGYRIIEKDIQGALLVDKLLEIGVKPGPLFKRLKDGEVVELENGTILNGNDFIGPPQKGRVITILGDTRYCEASRELAQDADVLVHEATFAAEDEQQAYDYFHSTSKQAASIALQANAKRLILTHISSRYQGDTYKELLKEARELFSNTEIATDLKSFPVDR
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: YBEY_RICPU
Sequence: MINVEIVRNYNKWREHKQINKSLIKKITQNILLRFDNFSKIKQFELSILLTNAAEILTLNKQFRNIEKATNVLSFPSNELNWQDLYSKLEFLGDSDYMHLGDIAFCYEVIYNESCEQHKTFENHFIHLLIHSILHLIGFDHQNDTEANIMENLEIEILSYFGIFPPY
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXG1_CHLPG
Sequence: MLDMGDRKEVKMIPKSSFSINSLVPEAVQNDNHHASHGHHNSHHPQHHHHHHHHHHHPPPPAPQPPPPPQQQPPPPPPPPAPQPPQTRGAPAADDDKGPQQLLLPPPPPPPPAAALDGAKADGLGGKGEPGGGPGELAPVGPDEKEKGAGAGGEEKKGAGEGGKDGEGGKEGEKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTFMDRAGSLYWPMSPFLSLHHPRASSTLSYNGTTSAYPSHPMPYSSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAALAASVPCGLSVPCSGTYSLNPCSVNLLAGQTSYFFPHVPHPSMTSQSSTSMSARAASSSTSPQAPSTLPCESLRPSLPSFTTGLSGGLSDYFTHQNQGSSSNPLIH
What is the function of this protein?
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
What are the official names of this protein?
Forkhead box protein G1, FoxG1.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y4273_RHOP2
Sequence: MAGHSQFKNIMHRKGKQDAQRSKAFSKLAREITVAAKLGTPDPAMNPRLRAAVIAARAENMPKDNIERAIKKAIGGDSENYDEIRYEGYGPGGVAVIVEALTDNRNRAASDIRSFFTKSGGNLGETGSVSFMFDRTGVIEYDADKASADDMLEAAIEAGADDVASSESGHEVYASQDTFRDVAKALEAKFGEARKAALIWKPQNTVAVDDETGEKLFKLMDHLNDHDDVQNVYANFEVSDALMAKMAG
What are the official names of this protein?
Probable transcriptional regulatory protein RPB_4273.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_BURM7
Sequence: MKLDLKILDARMRDYLPKYATTGSAGLDLRACLDAPVTLKPGDTALVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGNLVGLIDSDYQGELMISTWNRGQTEFALNPFERLAQLVIVPVVQARFNLVDDFAQSERGAGGFGSTGRG
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: KAD_CAMJD
Sequence: MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAQVASGSELGKTIDSFISKGNLVPLDVVVNTIVCALKAAPTKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVSEEVAKKRVLGRNRGADDNEEVFYNRMKVYTEPLNEILDFYQKKKLHFIIDGERTIEPIVADMKELIKKIQSI
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARCC_OENOE
Sequence: MANRKIVVALGGNAILSKDASAEAQQAALRETAKSLVSLVKENEKLIITHGNGPQVGNLLLQQMIGSTKSNPAMPIDTAVSMTEGSIGYWMQNAMDDVLEDEGIDKSAATVVTQVEVDANDSAFQNPSKPIGPFYEKEDINKIRELHPEYIYVEDAGRGYRRVVPSPKPVNVREYQVINSLVDNNVIPISVGGGGVPVVREGNHLIGCEAVIDKDFASEKLAELIKADLLIILTAVDNVYINFNKPDQKKLENVTVEELENYINENQFAKGSMLPKVQAAINFVNNGCGEAVVTSLKNINNFLQKGSGTIITK
What are the official names of this protein?
Carbamate kinase.
What is the protein family that this protein belongs to?
Belongs to the carbamate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIC_ECO8A
Sequence: MSHPALTQLRALRYFKEIPALEPQLLDWLLLEDSMTKRFEQQGKTVSVTMIREGFVEQNEIPEELPLLPKESRYWLREILLCADGEPWLAGRTVVPVSTLSGPELALQKLGKTPLGRYLFTSSTLTRDFIEIGRDAGLWGRRSRLRLSGKPLLLTELFLPASPLY
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCB5R_YEAST
Sequence: MAIDAQKLVVVIVIVVVPLLFKFIIGPKTKPVLDPKRNDFQSFPLVEKTILTHNTSMYKFGLPHADDVLGLPIGQHIVIKANINGKDITRSYTPTSLDGDTKGNFELLVKSYPTGNVSKMIGELKIGDSIQIKGPRGNYHYERNCRSHLGMIAGGTGIAPMYQIMKAIAMDPHDTTKVSLVFGNVHEEDILLKKELEALVAMKPSQFKIVYYLDSPDREDWTGGVGYITKDVIKEHLPAATMDNVQILICGPPAMVASVRRSTVDLGFRRSKPLSKMEDQVFVF
What is the function of this protein?
NADH-dependent reductase for KTI11/DPH3 and cytochrome b5 (PubMed:14930, PubMed:10622712, PubMed:27694803, PubMed:31463593, PubMed:34154323).  Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:31463593, PubMed:34154323, PubMed:27694803).  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:31463593, PubMed:34154323).  By reducing KTI11/DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex (PubMed:27694803).  The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (PubMed:10622712).  Plays a role in bud morphology (PubMed:17895367).
What are the official names of this protein?
NADH-cytochrome b5 reductase 1, Microsomal cytochrome b reductase, P35.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: STMN2_HUMAN
Sequence: MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
What is the function of this protein?
Regulator of microtubule stability.  When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons.  In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).
What are the official names of this protein?
Stathmin-2, Superior cervical ganglion-10 protein, Protein SCG10.
What is the protein family that this protein belongs to?
Belongs to the stathmin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane- bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia.
Protein: CR3LA_DANRE
Sequence: MENYSDQGGDGIELLDLLFDKNDGILRYENMGQQNNQLWPVQDPHMMMPPQGNEDFFNALIGGSDSVSGSPVWSPSPSDSGISEDPHSDHIDSPPPNASPPMEPHIVVSQTQHSLNINFPFDFNGWETGFLPDQAGGTQCASETPQAQPATGFPLTVKDLLLSGTPETAAKVSQQSYQELILTEDEKRLLAKEGMTLPNQFPLTKYEERILKKIRRKIRNKQSAQESRKKKKEYIDGLESRMAACSAHNHELQRKVFQLEKCNISLMEQLRRLQALVMNGSNKPVQAGTCVLVLLLSFTLILLPNLKPFTDTKVSQHGDFSPMRVQSRSLHNLQSSRVLRNLDHPYSMTENAKILPRFPEDKTMEEIASLLGRLHRRPQFTEYDPESHNHSFDQHDEHHHGDPITGHVATVTLNPRRGSRRSPHADDM
What is the function of this protein?
Transcriptional activator.  Binds the cAMP response element (CRE).  Activates transcription through box-B element and CRE.  Seems to function synergistically with atf6 (By similarity).  Regulates FGF21 transcription (By similarity).
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 3-A, cAMP-responsive element-binding protein 3-like protein 3-A.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 3-A]: Nucleus.
Protein: PYRB_CHLCH
Sequence: MKHLTGLCNCSAATIATLLELASDYKKELLKSNPQFQPTLCNKRIALVFFENSTRTRFSFELAARHLGASTLNFAAAASSVSKGETLSDTIKNLEAMQVDGFVLRHPSSGAANFITTITSRPVVNAGDGANEHPTQALLDLFTLQEHFGRLKGIRIIIIGDVLHSRVARSNIYGLLSVGAEVGLCSPVTLMPPDADQLGITMFTNLEDALAWADAAMVLRLQLERAAGGYLPSLEEYSVYYGLTDERLDRIQKNLLVLHPGPINREIEISNNVADRIQPPGYSKSMLLEQVTNGVAVRMAVLHTLLAENGK
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RDRP_RDVF
Sequence: MDLARSDIIPHLLCLFQEIIQANIQKVSEAYDLELKIMNILTLWRNGSDNLISDNDDYMKKGLFFSRSNDPLALQARYARMYDDLFKLNNYEVPDDVVRRHDNKILDIILKESSVPFWYDISDDEAHESMLPEFRLQDIHEFRLNLKRVRVVPDESEEIQMDESQSDKRRRKKRMEKSRPVWLSGSESDRRIELNDSLKPSQKFETKLSSYLLNRLMNEMNPHYCGHPLPALFVTLIMLKAYSIKNKFFSYGIRYMELVCNEIAGPDLNTRTFPVLFGSDGSFVGTRVYSHYPIKLRMILNDLTYLLTYSDLHKFQEFELDVNDEVLLHMLRTPNDGRQLKKAVTRLNHYYGLKFNPKTTDCGVVNGMDFTHKHPITKTADFTSPVLPMTNSFNKAEICYGHNSKILNRAVFTDTVRGHIREDLKNVADLDLPKLYEHVSKLVDMRVNYTIIYDLMFLRVMLNLGGYSRSNQITDFRKTIDEITKMNEGFLSGADPEKNIDTLNAWMAPTMEDCGYRLTKSILFGKFRKAKYPSDLEAKSNIDYYVTARSAGIGNLRISIETDKRKYKVRTTSKSAFVNAMGSGILDVNPVSNEPMMLTDYLLTQTPETRANLEAAIDSGSKSDSELMRILGQNSIGSRSTTAWRPVRPIYINVLQAHLAQAFIIGPHINATVNQHEYQPTSLWFTGDDLGVGFATLYQSGTADIIVPAIEASSTGKALSVLADCSSWDQTYLTATMIPYYNGIKRALLEYQQADMRNFYMIDSGRTGVPGMKLSEIVDWFNSFQTKRIFNASYLKERHSFVVKYMWSGRLDTFFMNSVQNALITRRIAEEVSLRVSNTGLSWFQVAGDDAIMVYDGSSISTTEQVTRINEITVRNYEESNHIINPQKTVISHISGEYAKIYYYAGMHFRDPSIQLHESEKDSGASDVTESLREFGQVIYEYNKRAIGTLRVNALYGRLIAGLAYSVNCPQYDASKRTYANMKYYPPPTSVIAPAAFKGGLGLSFTGLSLNEVLFIKLHLHEAVSQGLHVISMISFEANEVVSNSLSAYYLKDQKDLLRDMKLGKHLEKVKGISFKSSDLAFSGSDFSQGLNLKRESIDKVKLEVSRKSIRDLRSSGISVPSTHAYENLPYASLHQSFKSLKVDRDTSKFTNERLLVSLLEYKSDIPRVSVTSQYPVYDLINISKVDELNVRSGGPVRFISAPIEGKLLEENIGTRQGVQFKNRGYGGSQEVLHFIRSNGLVITEQALIDLIIKSGVLLMINPQRGLIDLFQSLSGDTASSMHLANFFMAEKPHWEDNAISLTIAGSLLENCDSRIENVKNFVSVLATGMQKDLQRMFYYVGFVYYAQRLIWSGGHSSKIFVSIDEDKLADFLRGSKPITRRRKAMAGTKREPINLSANFSYEISEPDREISEYDPLILCHPLSMPFFGNWQEKYSVMQSDEQM
What is the function of this protein?
RNA-directed RNA polymerase that is involved in both transcription and genome replication.  Together with the capping enzyme P5 and protein P7, forms an enzyme complex positioned near the channels situated at each of the five-fold vertices of the core.
What are the official names of this protein?
RNA-directed RNA polymerase P1, Replicase.
What is the protein family that this protein belongs to?
Belongs to the reoviridae RNA-directed RNA polymerase family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Located inside the inner capsid (PubMed:20190042). Found in the interior of spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: PACN3_MOUSE
Sequence: MAPEEDAGGEVLGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGAVEKGPQYGTLEKAWHAFFTAAERLSELHLEVREKLHGPDSERVRTWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHTARKDEKTAQTRESHAKADSSMSQEQLRKLQERVGRCTKEAEKMKTQYEQTLAELNRYTPRYMEDMEQAFESCQAAERQRLLFFKDVLLTLHQHLDLSSSDKFHELHRDLQQSIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRAISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPSSPGSGQDEDWSDEESPRKVATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA
What is the function of this protein?
Plays a role in endocytosis and regulates internalization of plasma membrane proteins.  Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane.  Inhibits the TRPV4 calcium channel activity.
What are the official names of this protein?
Protein kinase C and casein kinase II substrate protein 3.
What is the protein family that this protein belongs to?
Belongs to the PACSIN family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the inner aspect of the plasma membrane in myotubes.
Protein: METK_METPP
Sequence: MANDFLFTSESVSEGHPDKVADQISDAILDAIFAQDPRSRVAAETLTNTGLVVLAGEITTNAHVDYIQVARDTIKRIGYDNTEYGIDYKGCAVLVAYDKQSNDIAQGVDQASDDHLNTGAGDQGLMFGYACDETPELMPAPIYYAHRLVERQAQLRKDGRLPFLRPDAKSQVTMRYVDGKPHSIDTVVLSTQHSPDQSETAKKMKASFTEAIIEEIIKPVLPKEWLKDTKYLINPTGRFVIGGPQGDCGLTGRKIIVDTYGGACPHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLARQCQIQVAYAIGVARPMNITVYTEGTGVIPDDQLARLVAEHFDLRPKGIIQMLDLLRPIYEKTAAYGHFGREEPEFSWEKTDKANALRAAAGR
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPA_LEPBP
Sequence: MFQGVYTAVITPFRQGKIDYDSYFKILENQIRSGVAGVVPCGTTGESPTLSYEEHKELIQKTVQVVSGKIQVIAGTGSNSTKEAIELTESACADGVDGILSVNPYYNKPTQEGMFQHFTAIANVSSKPVMLYNIPGRTNVNLLPETVSRLAAHPKIAAIKEATGDLGQMAKVISQCPTNFDLLSGDDNLTLPVLSIGGKGVVSVVSNLFPRACVDMVSLYLRGDLEASKKIYYKLLPVFVNAFIETNPIPIKAAMSWFGYCSNELRLPMTSLSEGTASESFKKIVFQLKEEGIV
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.