PharMolix/UniProtQA huggingface dataset:
Protein: RPO5_METKA
Sequence: MAERLDPDVVLNHVLVPKHEVIDDEEEIEKILEELGVEKDDLPRIHTNDPVVVALSEKLGKRIKPGSLVKIVRDSPTAGKTVVYRVVTNPPE
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo5, DNA-directed RNA polymerase subunit H.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTFE_ECO8A
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLSRAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAOK1_MOUSE
Sequence: MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMSNSSVIHLKPEEENYQEEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASSWSHNPTGGPGPHWGHPMGGTPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
What is the function of this protein?
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability.  Phosphorylates MAP2K3, MAP2K6 and MARK2.  Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases.  Involved in G-protein coupled receptor signaling to p38/MAPK14.  In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6.  Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules.  Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade (By similarity).  During fetal development, it plays an essential role in the regulation of neuronal differentiation and migration to the cortical plate (PubMed:33565190).
What are the official names of this protein?
Serine/threonine-protein kinase TAO1, Thousand and one amino acid protein 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5HT2A_HUMAN
Sequence: MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
What is the function of this protein?
(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.
What are the official names of this protein?
5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Presynapse.
Protein: S47A1_HUMAN
Sequence: MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
What is the function of this protein?
Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534).  Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373).  Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373).  May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable).
What are the official names of this protein?
Multidrug and toxin extrusion protein 1, MATE-1, hMATE-1, Solute carrier family 47 member 1.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.
Protein: KA152_MESMA
Sequence: MKFSSIILLTLLICSMSKFGNCQVETNVKCQGGSCASVCRKAIGVAAGKCINGRCVCYP
What is the function of this protein?
Blocks both human ERG1/Kv11. 1/KCNH2 potassium channels (in a reversible manner) (PubMed:14599291) and A-type voltage-gated potassium channels Kv4/KCND (in an irreversible manner) (PubMed:11457451, PubMed:12473099, PubMed:12637022).  The presence of the Kv4-associated proteins DPP6 or DPP10 is mandatory to have high-affinity blockade of Kv4. 2/KCND2 and Kv4. 3/KCND3 channels (By similarity).  In contrast, the presence of the Kv4-associated protein KChIP1/KCNIP1 does not enhance the affinity blockade (By similarity).  May dispose of two functional faces (A and B); the two basic residues (Arg-40 and Lys-41) on the alpha-helix side of the peptide that blocks the hERG current (face A) and the typical dyad through which it blocks A-type currents on the beta-sheet side (face B) (PubMed:14599291).  In adult rat brain, it binds to sites in the striatum, hippocampus, superior colliculus, and cerebellum.  It shares the same target in rat brain than AaTX1 (AC Q867F4) and AmmTX3 (AC P60208).  In DPP6 knockout mice, A-type currents are much less affected by the toxin than in wild-type mice (PubMed:23440961).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 15.2, BmTX3, BmTX3A.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 15 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1027_STRZJ
Sequence: MYSISFQEDSLLPRERLAKEGVEALSNQELLAILLRTGTRQVSVFEIAQKVLNNLSSLTDLKKMTLQELQSLSGIGRVKAIELQAMIELGHRIHKHETLEMESILSSQKLAKKMQQELGDKKQEHLVALYLNTQNQIIHQQTIFIGSVTRSIAEPREILHYAIKHMATSLILVHNHPSGAVAPSQNDDHVTKLVKEACELMGIVLLDHLIVSHSNYFSYREKTDLI
What are the official names of this protein?
UPF0758 protein SPJ_1027.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: EFTU_CLOBK
Sequence: MAKAKFERSKPHVNIGTIGHVDHGKTTLTAAITTVLAQKGGASATKYDEIDKAPEEKERGITINTSHVEYETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLASRVGVQYIVVFLNKADQVDDPELIELVEMEVRELLNEYGFPGDDTPIVVGSALEVLENQDNAEKTKCIDELMEAIDSYIPTPERATDQPFLMPVEDVFTITGRGTVATGRVERGVLHTGDEVELIGMKQEVSKTVCTGIEMFRKILDEAMAGDNIGALLRGIQRDEIQRGQVLAKPGSVTPHKKFVGQVYVLKKEEGGRHTPFFNGYRPQFYFRTTDVTGSINLPEGVEMVMPGDHIDMAVELITPVAMHENLRFAIREGGRTVGSGVVTTISE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_METJA
Sequence: MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELDLAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFNYKRLDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGALAVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Probable porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CAPP_RHOPB
Sequence: MSSKIMPIDPIAQKTPVAEDPAAIDEDARLRDDIRLLGRILGDTVRDQEGEGVFDVVERIRQTSIRFHRDNDKPARSELEAILDGLSTPDTVRIVRAFSYFSHLANIAEDQNNIRQMRALSGTPRPGSVVGTLAHARAVGISAQELRRFFAHALVSPVLTAHPTEVRRKSTMDREMEVAGLLDRRERLQMTAEEVAQHEEQLRRAVLTLWQTNMLRRTKLTVLDEVKNGLSFYDHSFLREVPRLHGLLEDRLNDDDGRDEELASFLRMGSWIGGDRDGNPFVTAEVMRGALRLQSTRALRFYLDELHALGSELSIAAHLADVSDDLRLLAERSPDTSPHRSGEPYRLAVSGIYARLAATAHKLKFDDIRAPVGAAEPYADPQEFKADLDVLHRSLIANQASVIARGRLRQLRRAVDCFGFHLASLDMRQNSAVHERTMTELIDAAMPGKSYMAMNEEARIALLAGELRSTRPLASPFVKYGEETLGELAVFRTAAEAHAAFGHTVISQCIISMCKGVSDMLEVVLLLKEVGLVDHAGRSAINVVPLFETIEDLQASAGIMDRLLSLHDYRRLVDSRGGVQEVMLGYSDSNKDGGFVTSGWELYKAEIELVKVFEHHGVRLRLFHGRGGSVGRGGGPSYDAILAQPGGAVNGQIRITEQGEIITSKYSNAEVGRNNLEILAAATLEASLLMPRQSAPRAEYLDAMEQLSSFAFKAYRGLVYETEGFEDYFWASTVITEIATLNIGSRPASRKKTHKIEDLRAIPWVFSWAQCRLMLPGWYGFGSAVEAFVKEHPDKGMAFLQELYREWPFFRTLLSNMDMVLAKSSIAIASRYAELVPDEQLRQAIFGRIRAEWHGSIQALLDIMQQDRLLQSNPRLERSIRNRFPYLDPLNHVQVELLKEHRSHAIDEKVLRGIQLTINGISAGLRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: CSRN1_PONAB
Sequence: MTGLLKRKFDQLDEDNSSVSSSSSSSSSSSGCQSLSCSPSSSVSRASDSEEEGPWDQMPLPDRDFCSPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTSVPSRGGCTLGMAPRHSACRRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAGAPKAEAGLPPAVDAIDDASVEEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRRIDREEKRELQALRQSREDCGCHCDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCENPMGRVEFNQARVQTHFIHTLTRLQLEQEAESFRELEAPAQGSPPSPGEEALVPTFPLAKPPMNNELGDNSCSSDMTDSSTASSSASGTSGAPDCPTHPGLPGPGFQPGVDDDSLARILSFSDSDFGGEEEEEEEGSVGNLDNLSCFHPADIFGTSDPGGLASWTHSYSGCSFTSGILDENANLDASCFLNGGLEGSREGSLPGTSVPPSMDAGQSSSVDLSLSSCDSFELLQALPDYSLGPHYTSQKVSDSLDNIEAPHFPLPGLSPPGDASSCFLESLMGFSEPAAEALDPFIDSQFEDTVPASLMEPVPV
What is the function of this protein?
Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity.  May have a tumor-suppressor function.  May play a role in apoptosis (By similarity).
What are the official names of this protein?
Cysteine/serine-rich nuclear protein 1, CSRNP-1, Axin-1 up-regulated gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the AXUD1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS15_CHRSD
Sequence: MALTAEQKATIVNEYGRGENDTGSPEVQVALLSANIDGLQDHFKSNKQDHHSRRGLIRMVNQRRKLLDYLKRKDFERYQSLIQRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PURA_RHOE4
Sequence: MPAIVLIGAQWGDEGKGKATDLLGEQLQWVVRYQGGNNAGHTVVLPNGDKFALHLIPSGILTPAVNNVIGNGVVVDPGVLLTELAGLEERGVDTSRLLLSADAHLIMPYHVAIDKVTERFLGAKKIGTTGRGIGPCYQDKIARVGVRAADVLDEKILTQKVEAALEFKNQVLVKIYNRKALDPQQVVEEVLTQAEGFKHRISDTRLELNLALERGETVLLEGSQGTLLDVDHGTYPYVTSSNPTSGGAAVGSGIGPTKITTVLGILKAYTTRVGSGPFPTELFDDHGAYLAKQGGEVGVTTGRARRTGWFDAVIARYATRVNGITDYFLTKLDVLSSLDTVPICVAYEVDGVRHDEMPMSQSDIHHAKPIYEEMPGWWEDISEARTFEELPQNAQNYVLRLEELSGAFISCIGVGPGRDETIVRREIVR
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_ALIF1
Sequence: MQEQYNPQDLEQKIQKHWDDNKTFVVTEDANKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVSRYQRLQGKNVMQPIGWDAFGLPAENAAVKNKTAPAPWTYENIEYMKNQLKLLGFGYDWNREFATCTPEYYRWEQEFFTKLYNKGLVYKKTSSVNWCPNDQTVLANEQVEDGCCWRCDTPVEQKKIPQWFIKITEYAQELLDDLDNLDGWPEMVKTMQRNWIGRSEGVELSFAVNGETSPLEVYTTRPDTLMGVTYVGIAAGHPLAEKASQNNPELAAFVEECRNTKVAEAELATMEKKGMDTGLRAIHPLNGREVPVFVANFVLMDYGTGAVMAVPAHDQRDFEFATKYGLDIIPVIKPEDGSDLDVSEAAYTEKGVLFDSGEFDGLAFQEAFDAIAAKLEAEGKGKKTVNFRLRDWGVSRQRYWGAPIPMVTTEDGEVHPVPADQLPVILPEDVVMDGVTSPIKADKEWAKTTFNGEPALRETDTFDTFMESSWYYARYCSPQADDILDPEKANYWLPVDQYIGGIEHACMHLLYSRFFHKLLRDAGYVTSDEPFKQLLCQGMVLADAFYYTNDKGGKEWVAPTDVTIERDGKGRIEKAIDDQGREVEHSGMIKMSKSKNNGIDPQEMVDKYGADTVRLFMMFASPADMTLEWQESGVEGANRFLKRVWKLVHEHTNKGTTEALDTSSLTGDQKALRRDVHKTIAKVSDDIGRRQTFNTAIAAIMELMNKLNKAPQESAQDRALLDEALKAVVAMLYPMTPHASFAMWEALGESDLDSATWPTFDENALVEDEKTIVVMINGKLRAKLVVAADATEEHVRELGLKDENAMKFLDGLTIRKVIYVPGKLLNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_STRSV
Sequence: MPTSRNDDMMVFCSFCGKNQDEVQKIIAGNNAFICNECVELAQEIIREELAEEVLADLSEVPKPQELLNILNHYVIGQDRAKRALAVAVYNHYKRINYHDSREEEDVELQKSNILMIGPTGSGKTFLAQTLARSLNVPFAIADATALTEAGYVGEDVENILLKLLQAADFNIERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDTKNILFIVGGAFDGIEEIVKQRLGEKIIGFGQNNRAIDEDSSYMQEIISEDVQKFGIIPELIGRLPVFAALEQLTVDDLVRILKEPRNALIKQYQALLSYDDVKLEFDEDALQEIANKAIERKTGARGLRSIIEETMMDVMFEVPSQENVKLVRITKEAVDGTDKPILETA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: YL046_MIMIV
Sequence: MNTFDNLDFISEKLATQKRASPARSRQMIKRSKNRKSRVLTDEENRKFTKQEKKHLHKLAKKNAKETKDSGVMRKTCQRLDVSTLNVIEDDIYICSSDEEREDNDVASVLVEKPEPCGSGWVCDEWSGGYYWVQFYATKPDFKPNESGNWFFDEWDRGYYFSNF
What are the official names of this protein?
Uncharacterized protein L46.
Protein: CD051_MOUSE
Sequence: MTHFLYLTPEILLPFSPLTSTEFELIRRKAQQLWQDETRWSASSMTTYSGSYREKQLDEATCNRLAQRVGQPQFEYKPTPLPGSSAYNTLPGHAGSQEAADGKGRLPDIASPSRDSPLNIKHKVAHQIWGSEVPCPTFLAYRGLRMSPCMQPKKPGFELLMSYRNRGKALLKRLQRQWDYESKLGSSEDSGTDRFSSNTSGSSGRKFK
What are the official names of this protein?
Uncharacterized protein C4orf51 homolog.
Protein: IF2_CAUSK
Sequence: MSDENDNGRPGSNPGGRAPITLKPRQGSVSAGVVKQSFSHGRTKTVVVETKRVRPHAPPAGNLAAPSSAERRQGDAPRQQSSSGGGGSSAGGLSQGEMLARQRAIEAAREHQERQAAERRAAEARAASEAAAARDAAAKSAAAAKAAAAPAPEAPAAPAPTPAPVAQAPAAPVVQAPVVAAPVQAPAAPVAAAPAAPRAEAPRPAPPPVRSDAPRPAPTAGQTRTYEPSRDRRDDRSSTTTYRPGPGAPPQGDRPQGDRPQGDRPFNQRAPRPDGPYNQRTPRPDAGGPPRGPRPEGAGGFRNDRPQGDRPQGDRPQGDRPQGDRPTQTVRYSALAPRPAPGARPGPGGPRGARPGVPASAPATPEIQRATRSAPRPGGDVGRKPEEDDDRRKAAAPGKAVSRAKGAPIRREGRLTIQTVAGDGDSADRMRSLASVRRAREREKEKRRGGPADVVKVAREVIIPDVITVQELSNRMAVRGVEIIKFLMRQGVMLKINDVIDNDTAELVATEFGHTVRRVSEADVEEGFIGAEDVDDHLEPRPPVVTVMGHVDHGKTSLLDALRKADVASGEHGGITQHIGAYQVRLESGQKVTFLDTPGHAAFSQMRARGANITDLVILVVAGDDGVMPQTVEAIKHARAAEVPIIVAVNKMDKPGADSTRVVNELLQHEIVVESLGGDTQIVEVSAKTGQGLDELIERILLLAEVMDLKANPDRTADGVVIEAKLDKGRGAVSTVLVKRGTLKRGDIVVAGSQFGRVRALLNERNEQLTEAGPATPVEILGLDGVPSPGDPFAVVENEARARELTEYRIRLKREKSMHPVGAGATSMADMMAKLQDKKYRELPLVIKADVQGSAEAIIGSLDAMSTDEVRARIILSGAGAISESDVMLAKGAGAPLIGFNVRASAQARALAEREGVEIRYYAIIYDLLDDIKGVLSGMLAPIQRETFLGNAEVLQAFDISKVGKVAGCRVTEGVVRKGAKVRIIRNDIVVLELGTLQTLKRFKDEVPEVPSGQECGMMFAGFQDIKVGDTIECFTVEEIKRQLD
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_FRAP2
Sequence: MLSIIQRVNCANVVVDGQKVADINKGILALVCVEKEDTHQNFEKMTDKIIKYRIFEDEAGKMNLSLADINGEIILVPQFTLAADTKKGNRPSFSSGCPPEIAKEKFKKFVDIFKNKYDKVQTGIFGADMKVSLTNDGPVTFTFKV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLRI2_MOUSE
Sequence: MHKKKHIKHGTNKQEIINIGTKSPTFQEKQRPSKTDQRSTVWREEQKKQELKVHRIFHPQPRTGFDVGKGIDPWLTTWQMITVILATLCIILVTKVGFLIPSLFSKGEKQSRKFSLLDPLCDRNDDSSCDFCSSDWIAFGNNFYCVFRENSKTWVESQSACEELNSHLVIIDSKAEVENLLLFEMDGWILHRMDGTNSSRLWGNDIKIRNTLMNDSEKKNHSCHYLRGNIFMPDECSAKKTYICEFNI
What is the function of this protein?
Lectin-like receptor for natural killer (NK) cells.  Heterodimer formation with KLRE1 mediates NK cell cytolytic activity.
What are the official names of this protein?
Killer cell lectin-like receptor subfamily I member 2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: TTCA_XYLFM
Sequence: MDATFPSQRNITTRPAPDRIRREKCKLAKRLRRQVGQAIADFGMIEANDKIMVCLSGGKDSYTLLDMLLQLRAKAPVPFELTAVNLDQKQPGFPKHVLPEYLSSIGVPYHIIEQDTYSVVTRVVPEGKTLCALCSRMRRGALYAYAETQGFTKIALGHHRDDMVATFFMNLFHHAKLSGMPPKLRSDNGKHVVIRPLAYVSETDIIAYADAREFPIIPCNLCGSQENLQRKQVGVMLKAWEKEYPSRIEQIARALGNIRPSQLADQSLFDFLALGRHSNTPLPNAHAWLAGDLANDTAP
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NINJ1_HUMAN
Sequence: MDSGTEEYELNGGLPPGTPGSPDASPARWGWRHGPINVNHYASKKSAAESMLDIALLMANASQLKAVVEQGPSFAFYVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLVFIIVVVNIFITAFGVQKPLMDMAPQQ
What is the function of this protein?
Secreted form generated by cleavage, which has chemotactic activity (By similarity).  Acts as an anti-inflammatory mediator by promoting monocyte recruitment, thereby ameliorating atherosclerosis (PubMed:32883094).
What are the official names of this protein?
Ninjurin-1, Nerve injury-induced protein 1.
What is the protein family that this protein belongs to?
Belongs to the ninjurin family.
Protein: MCEL_RFVKA
Sequence: MDDSKKKRGTDYIEELILLYEDVPNPVQTDDMNHEVELTFIQPPVITLSTLLPFATSQESYILFTVTNKGVKIRNRINLSKIHGLDLKNIQLVDSIDNIIWEKKTLVKEHKIDSVALVKYSTEEKYIFLDYKKYLSAIKLELVNVVQVKVKHVTVDFKFKYFLGSGAQAKSSLLHVLNHPKSKPNPSLEFEIITTDEKIDSASLRKELIALFKLVFMASPSNIILDVVFKNPVQTILLKKNELPGIDLTNLYVTTKTDGVGVLITVTNKGIYCFFTHLQYTIRYDTTFESNESVTLYGEAVKQNNVWQIYLIKLITPKVSDRFKEKEYVEERLQNICDRMTFKVKKYEGPFESHSEIIDLLTTYLPSQPEGVVLFYSDQRNQPDYKIKLDNTTDHMINIIYRYMSSEPVIFGENSTFLEYKKFSDDKGFPKDYGTGKLMLTDNVRYLNNIYCIAFTNVYEDVGIKNVVVPIKFISEFSATGELIKPRIDKTFKYLYKEYYGNQYQIVVAHIRDQNIKIGDVLDEDKLSDVGQHYANDKYRLNPDVSYFTNKRTRGPLGILSNYVKTLLISLYCSKTFLDNSNKRKVLAIDFGNGADLEKYFYGEISSLVATDPDKEAIGRCIERYNSLNSGIKSKYYKFDYIQETIRSVTYVSSVREVFFFGKFDLVDWQFAIHYSFHPKHYATVMNNLTELTASGGKVLITTMDGDLLSQLTDKKTFVIHKNLPSSENYMSVEKIHEDQILVYNPSSMSRPMQEYIVKRVNLTKIFSEYGFELIDCVHFDTIIERSKRFINSVSKMEERKSTKNFFELNREALKHEGTDIDDLLRYYIVYVFSKR
What is the function of this protein?
The heterodimeric enzyme is also involved in early viral gene transcription termination and intermediate viral gene transcription initiation.  Early gene transcription termination requires the termination factor VTF, the DNA-dependent ATPase NPH-I and the Rap94 subunit of the viral RNA polymerase, as well as the presence of a specific termination motif.  Binds, together with RAP94, to the termination motif 5'-UUUUUNU-3' in the nascent early mRNA (By similarity).
What are the official names of this protein?
mRNA-capping enzyme catalytic subunit, Virus termination factor large subunit, VTF large subunit, mRNA-capping enzyme 97 kDa subunit, mRNA-capping enzyme large subunit.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome.
Protein: KGX47_CENLI
Sequence: DRDSCVDKSKCAKYGYYGQCDECCKKAGDRAGNCVYLKCKCNQ
What is the function of this protein?
Reversibly blocks Kv11/ERG potassium channels.
What are the official names of this protein?
Potassium channel toxin gamma-KTx 4.7, CllErgTx4, CllErg4, ErgTx4, Ergtoxin-like protein.
What is the protein family that this protein belongs to?
Belongs to the ergtoxin family. Gamma-KTx 4 subfamily.
What are the subcellular locations of this protein?
Secreted.