PharMolix/UniProtQA huggingface dataset:
Protein: CENPN_MOUSE
Sequence: MKENVAEFLRRTILKIPLSEMKSILEAWDFLSEDQLQTINLKQRKDYLAQEVILLCEDKRASLDDVVLLDIVYTQFHRHQKLWNVFQMSKEPGEDVDLFDMEQFQSSFKRILQRALKNVTVSFRVYEKDSVWIRVAWGTQYSQPNQYKPTFVVYYPQTPYAFISSCHLKNTVPLLHQALKVASKHHQIVHLDLRSRHLDSLKAIVFREYNQTCENYSSTTSLQEASLSMCLDSKITHENTEEKVRVHRVTQETFGTYPQPQLEFAQYKLETKFKSNIGGGLLADRKEPFRCLVKFSSPHLLEALKSLAPAGIADAPLSPLLTCIPSKKMNYFKIRDK
What is the function of this protein?
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.  CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly.  Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
What are the official names of this protein?
Centromere protein N, CENP-N.
What is the protein family that this protein belongs to?
Belongs to the CENP-N/CHL4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
Protein: CLPP_LACAC
Sequence: MLVPTVIEQTARGERAYDIYSRLLKDRIIMLSGEINDQMANSIIAQLLFLDAQDNTKDISLYINSPGGVITSGLAIMDTMNFIKSDVSTIAIGMAASMASILLTSGTKGKRFALPNSTVLIHQPLGGAQGQQTDIQIAANEILKSRKKINEILHETTGQPLEKIQKDTERDNYLTAEEAKEYGLIDEIMVNKKSN
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_BRUMB
Sequence: MRVVFMGTPEFSVPILTAIIGHGYEVVAAYTQPPRPAGRRGLELTRSPVHEKAEQFGIPVFTPKSLKGAEEQDVFASLKADVAIVVAYGLLLPKAILDAPRLGCYNGHASLLPRWRGAAPIQRAIMAGDAETGMMIMKMDEGLDTGPVAMAEKVAITPDMTAGELHDRLSMIGADLMIRALGALERESLALQPQAEEGVTYAAKIDKAEARIDWSKPAKDVHNSIRGLSPFPGAWCEMEINGAVERVKLQRSTLGEGSGAPGTVLDDRLTIACGEGAVRLATLQRSGGKPLPAQEFLRGQRVTKVL
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: HG2A_MOUSE
Sequence: MDDQRDLISNHEQLPILGNRPREPERCSRGALYTGVSVLVALLLAGQATTAYFLYQQQGRLDKLTITSQNLQLESLRMKLPKSAKPVSQMRMATPLLMRPMSMDNMLLGPVKNVTKYGNMTQDHVMHLLTRSGPLEYPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKKPTEAPPKVLTKCQEEVSHIPAVYPGAFRPKCDENGNYLPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNCSEPLDMEDLSSGLGVTRQELGQVTL
What is the function of this protein?
Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.
What are the official names of this protein?
H-2 class II histocompatibility antigen gamma chain, Ia antigen-associated invariant chain, Ii, Ii chain, MHC class II-associated invariant chain.
What are the subcellular locations of this protein?
[Isoform Long]: Late endosome. Lysosome. SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
Protein: DXR_CLOBB
Sequence: MKKLSILGVTGSIGTQALDVIKKSNGELKLIGATANSSVNKMIEIIEEFNPKYVGMMDKNSADKLEKYCKERNKQTIVLSQMEGLNKIASLEEIDIVLTSLVGMIGLEPTLEAIKAKKDIALANKETLVVAGELVMSEAKKNNVKILPVDSEHSAIYQSLRGNDLKTLNKIILTASGGPFRGKKLCDLNDIGVDDALNHPKWNMGRKISIDSATLMNKGLEVIEAHWLFNCDYDNIQVVIHPQSVVHSMVEYCDGSIIAQLGAADMRLPIQYAFNYTERKNLIAKTLDFYEVAQLTFEKPDLETFKPLKLAFKAGKQGGLMPTILNGANEAAVALFLDEKIEFLDIFNIIENCMNTFEEETKKPLTLENIIELDKKVKKYVVDMK
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RSMC_ERWT9
Sequence: MSAFTPASEVILRHSDEFTQRRVLFAGDLQDDLPAQLETALSRVHTQQYHHWQILSRVLGENAHYGLFASAETLADCDTLVYYWPKNKPEAQYQLQNLLALLPVGSDIFVVGENRSGVRSAEQMVADWAKLEKIDSARRCGLYHGRLDSRPTFDADTFWDEYPLGELTVKTLPGVFSRDGLDIGSQLLLSTLKPHMKGKVLDVGCGAGVLSAMLASFSPKVRLTLTDVNAAAIASSKATLAANQLEGDVFASNVYSDISGRFDMIISNPPFHDGVQTSLDAAQTLIRGAVSHLNTGGELRIVANAFLPYPQVLDETFGSHEVLLQNGRFKVYRAVKSRAAKK
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDR_PROM0
Sequence: MQCPTCQNTDSRVLESRSADSGKSVRRRRECLNCSFRFTTYERVESMPVSVLKKDGSRELFDKQKLFTGISRACEKTNFSSEAIINFVDGIESQIVQDTNKDIKSSQIGELILKNLRKENEVAYIRYASVYRKFNGVKDFISTLESLKGSSKNQLASIS
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: SAP_ARATH
Sequence: MSTSSSSSDNGAGGSGGVFEAPSPSRPRRGANDVWPEPFLESLAVQVAVNASTSAGLLAAAPALANVFRVCTTWHAVSRSDHLWQLLSRQVWARTHLMHDTWRDEFIYRHRTARNFRTRTHTYFTLQFDPSDVDEPDSLSCRCLTLSDLYLAAGFADGTVRLFLLNNRLHVRTLRPPLRDRFGRFSRAVSGIVISDSRLTFATMDGDIHVAEIDGVGHTRTAYAGDIVNDGALVDFTGCGRWWVGLFAGVPGRAFHIWDCNSEETTFVGGTLTDPEAVMGWHTLTELTTSLGRLRISGNETAVACTRWRIMVIDLRNQGVIIGEDEEQRRGLIVTGFDANDEAYVRLDSRGNASVRRVNTQQTVCEFRVSGAAQRRVMGCVNRLHALMCAGGIMRVWEVERGEYLYSIRERVGEVDAIVADDRHVAVASASSTAQSIIHLWDFGAL
What is the function of this protein?
Transcriptional regulator involved in the specification of floral identity.  Acts as A class cadastral protein by repressing the C class floral homeotic gene AGAMOUS in the external flower organs in association with APETALA2 and other repressors.  Is required to maintain floral meristem identity in concert with AGAMOUS.  Interacts also with APETALA2 to ensure the normal development of ovule.
What are the official names of this protein?
Transcriptional regulator STERILE APETALA.
What are the subcellular locations of this protein?
Nucleus.
Protein: FUB5_FUSO4
Sequence: MSWGKLSPKANNVMIICHALSGSADVSDWWGPLLGPGKAFDTDKFFVVCMNSLGSPYGTASPVTAKNGDYSQGWYGADFPSTTIRDDVRLHKLVLDKLGVRKVAAVIGGSMGGMHVLEWAFFGKDYVRCIVPAATSSHQSAWAIGWGEAQRHAIRSDVKYKNGRYGFDDPPILGLEAARMTALLTYRSRDSLERRFGRDTGNKKKTQQQDSKTIPNNGTPIHSQGGADETPVAFDRADSNFAAQSYLRYQAKKFSDRFDSNCYIALTNKLDTHDLARGRTRTIAEALSLIQQPTLVLGIRSDGLYTLAEQEQIARAVPNAKLREIVSDDGHDAFLIEWSQLNWLLIGFLHENLPDIMQRAAL
What is the function of this protein?
Homoserine O-acetyltransferase; part of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:25372119).  L-aspartate is suggested as fusaric acid amino acid precursor that is activated and further processed to O-acetyl-L-homoserine by cluster enzymes aspartate kinase FUB3 and homoserine O-acetyltransferase FUB5, as well as enzymes of the primary metabolism (By similarity).  The polyketide synthase (PKS) FUB1 generates the triketide trans-2-hexenal which is presumptively released by the hydrolase FUB4 and linked to the NRPS-bound amino acid precursor by NAD(P)-dependent dehydrogenase FUB6 (By similarity).  FUB1, FUB4, and the non-canonical NRPS Fub8 may form an enzyme complex (By similarity).  Further processing of the NRPS-bound intermediate might be carried out by FUB6 and the O-acetylhomoserine FUB7, enabling a spontaneous electrocyclization to close the carbon backbone of fusaric acid (By similarity).  Dihydrofusaric acid is likely to be released via reduction by the thioester reductase (TR) domain of FUB8 whereupon the final oxidation to fusaric acid may (also) be performed by the FMN-dependent dehydrogenase FUB9 (By similarity).
What are the official names of this protein?
Homoserine O-acetyltransferase FUB5, Fusaric acid biosynthesis protein 5.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
Protein: ISPE_PECAS
Sequence: MQPTVIETWPAPAKLNLFLYITGQRQDGYHLLQTLFQFLDYGDTLTIRPRNDDQINLLTPIDGVENEQNLIIRAARLLQQHCERRNIRPAQFGANIHIEKCLPMGGGLGGGSSNAATVLVALNHLWQSGLNVDTLAELGLQLGADVPVFIRGYAAFAEGIGEQLTPANPPEKWYLVAHPSISIATPLIFGDPELTRNSPVRDLETLLNQTFVNDCEAIARKRFREVEQLLSWLLEYAPARLTGTGACVFAEFDTEFAARQVLDQAPEWLNGFVARGVNVSPLQRRLSGQR
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: FBPC_ECOLI
Sequence: MTQKNFVELRNVTKRFGSNTVIDNINLTIPQGQMVTLLGPSGCGKTTILRLVAGLEKPSEGQIFIDGEDVTHRSIQQRDICMVFQSYALFPHMSLGENVGYGLKMLGVPRAELKARVKEALAMVDLEGFEDRFVDQISGGQQQRVALARALILKPKVLLFDEPLSNLDANLRRSMRDKIRELQKQFDITSLYVTHDQSEAFAVSDTVLVMNKGHIMQIGSPQDLYRQPASRFMASFMGDANLFPATFSDGYVDIYGYHLPRPLHFGTQGEGMVGVRPEAITLSDRGEESQRCVIRHVAYMGPQYEVTVEWHGQEILLQVNATRLQPDVGEQYYLEIHPYGMFVLADAA
What is the function of this protein?
Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Fe(3+) ions import ATP-binding protein FbpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MRKC_DICDI
Sequence: MESNKSSSHGDVSTSPSFLNNHHQFNNGGDIIPKKKKNRIMHVGSYEVGKTLGNGTFGKVKLGTNICTKENVAIKFIKNNKLSGKQKETCFREIDIMKLLDHPNIVKLLDVVDKREEEGTTYLIVEYVSGGELFDYIVAREYIKEKEARKFFRQMISAIEYCHANLIVHRDLKPENLLLDSNGDIKISDFGLSNNIQPGKLLESFCGSPLYAAPEILKAEKYLGPPVDIWSLGVIMYAVLCGNLPWEGDSQAEISFNSVHGNYEDPTHLSAEAVHILRRMIVPNPKDRATIQELKNHPWTNIDYQEIPKSHLPPRDAVHEIKEDIFAHLISLGFPNTKETRDIILKNENCGIVNVYHLLLDRYASKEVENLKSKLELLSKRKKSFSDKRNPSTNSLASIPEDSNDLSSNNNNNQQQQNSPPSKTNSSSTSSSNRESNNNSPSQGSIKEISLDELDNHIEQLDNDIENSDNNKSSSLTRRSSDPNKDIENSLKAQGLFSSYSAPGVPNSDHNYDFETYQQQQQYQQQLHQQQLQLQQQYQSQIQSDISFPHDDVEIESYSIQQQQLQQQQQQQQEQHKEDNNKPNTNLRRNSIAVSTFMEDEPNEMPINNLYKMNEQIQQQPIIGGSGNVMRSQFNQTLPTIDQQPVIEAPKTRRMSLDSRMLNGDQQSLVEKNQHMASPRTSKGIFKSSTTTTKSPEKTIIELKRSLEESGLFTKKKGPYLFLCFDEDNSVKFQIEIVKICNLDLTGIQLKRLSGDTWKYKDICTELVESMKL
What are the official names of this protein?
Probable serine/threonine-protein kinase MARK-C.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Protein: AR6P4_RAT
Sequence: MAHVSSRKRSRSRSRSRGRRGSEKRSKRSSKDSSRNCSTSKSQGHKASSTSGVEERSKHKAQRTSRSSSSSSSSSSSSSSSSTSSSSSSDGRKKRGKHKDKKKRKKKKKRKKKMKRKGKEKAVVVHQAEALPGPSLDQWHRSAGEDNDGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRKVVDPETGRTRLIKGDGEVLEEIVTKERHREINKQATRGDGLAFQMRAGLLP
What is the function of this protein?
Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site.
What are the official names of this protein?
ADP-ribosylation factor-like protein 6-interacting protein 4, ARL-6-interacting protein 4, Aip-4, Splicing factor SRrp37.
What is the protein family that this protein belongs to?
Belongs to the ARL6IP4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus speckle.
Protein: RL22_DESVH
Sequence: MESRATAKFMRVSPRKTRLVARNIDGLPVEDAMNLLRFTPNKPAGVLYDVLRSALANAQQMPGVDVDAMVVKQVVVNEGPSWKRFLPRAQGRATRIKKRTSHITVILAEGQE
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: TIG_MYCA1
Sequence: MKSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGFRPGKAPAKLLEARFGREAMLDQVVTEALPARYGQAVAESEVHPLGQPEIEVTKKEYGQELAFTAEVDVRPELNLPDPGALKISVDPIEVTDEDVDAELQSLRARFGTLTGVERPVAEGDFVSIDLSATIDGQEVPGATAQGLSHEVGSGRLIEGLDEALIGMSVDESREFTTKLVSGEHAGQDAQVTVTVKSVKERELPEPDDEFAQLASEFDTIDELRANLREQVGRVKRAQQAERIRDAAIDTLLEQVDIPLPEAIVKAQVDSALHGALHSLNHDESKLEEVLAQQGKSREEFENETRTAAETDVKKQLLLDALADKLQVQVGQEDLTERLVATSRQYGIEPQQLLAYLQENNQLPAMFADVRRALAIAEVIRAATVTDTAGNTIDTSEFFGKRPSGDGAADEDADQADESTTADAGE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: IF2_CYTH3
Sequence: MAEEKMMRLSQVAKKLNVGTSTIIDHLSAKGYDIENNPNAKITVDMYAFLSKEYESSAQVKKEAESLTIGKKHMGDVVIDADQVNVAPEHDEEDEVRIINNSPAEAVVPEVPAVTAQEAPKTAPTAESPEDVKGNVTLQGLKVLGKIDLGTADKDSKKSAKNTKPVEKVAAEKPIEKAKPETVAPPVEPKPEPKQETPKTEQPVKKETPKAETQKPPVADKPAEKTPVVEEPAAPVADVPVQVVQAHADKLQGLTVLGKIQLPDKKKEPTRVASSDEVVDKNKNKRKRKRLNDGPNKPAGANPNGPRPAGSNPNGPRPQGTNPNGPRPQGQGGNPNGPRPAGGPNRPGVPNRPNSNGPKPTLTKASEKGEVTGKQIQDKIKATMAKLSGGGTKSGPVNRAKYRKDKRSAMADAEEERLMAEQEDAKSLKVAEFISASDLASLMDVSINEVISKCMAMGMFVSINQRLDAEAITIIADEFGYDVNFQTTGEEDDVTDVDQDDPASLIDRAPIVTIMGHVDHGKTSLLDYIRKSKVVAGEAGGITQHIGAYNVMTDSGKPITFLDTPGHEAFTAMRARGAKITDIVIIVVAADDSVMPQTKEAINHARVAGVPIIIAINKIDKPAANPDKIKEELSKENILVEDWGGKYQCQAISAKAGTGISELLDKVLLEAEMLELKANPDKRAIGAVIEASLDKGRGYVTNVLVEAGTLRIGDIILAGAHFGRVKAMVDHTGKKLKEAGPAMPLQVLGLNGAPQAGDKFQVMETEREAREISSKREQLLREQSIRTKKHITLDEIGRRLAIGNFKELNIIVKADVDGSVEALSDSLLKLSTEEIQIRILHKGVGQISESDILLASASDAIIVAFQVRPSTSARKLAEQEQIEIRMYSIIYDAINEVKDAMEGMLEPKMEEVVLGTIDVRDVFKITKVGTVAGAYVSEGIVKRNNQVRLIRDGIVMFTGTISALKRFKDDVSEVKTSYECGISLKGYNDIQIGDQIEAFEQKEVKRTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_HELHP
Sequence: MFNIISKKYTQALVDSGSNLDETLSILKGLSLALKDKRNADIIASPFLSKTQKEQFLLESVGKVDMKLQNFFRLLAQSDRILLIPYISDELERRLLARKKEYAATLTAKESLDTKTLEKIQDSLAKKLGVKLSIKQRLSEVDGIKLSVEDLGIEVSFSKERFSNDLKHHILKAL
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: EFP_MYCLE
Sequence: MATTADFKNGLVLVIDGQLWTIIGFQHVKPGKGPAFVRTKLKNVLSGKVVDKTYNAGVKVDTATVDRRDTTYLYRDGANFVFMDSQDYEQHPLPESLVGDTARFLLEGMSVQVAFHNGVPLYVELPVTVELEVTHTEPGLQGDRSSAGTKPATLETGAQINVPLFINTGDKLKVDSRDGSYLGRVNV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPCL1_MOUSE
Sequence: MAAAWQGWLLWALLLNSAQGELYTPTHKAGFCTFYEECGKNPELSGGLTSLSNISCLSNTPARHVTGDHLALLQRVCPRLYNGPNDTYACCSTKQLVSLDSSLSITKALLTRCPACSENFVSIHCHNTCSPDQSLFINVTRVVQRDPGQLPAVVAYEAFYQRSFAEKAYESCSRVRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGKITPCNESQGEDSAACSCQDCAASCPVIPPPPALRPSFYMGRMPGWLALIIIFTAVFVLLSVVLVYLRVASNRNKNKTAGSQEAPNLPRKRRFSPHTVLGRFFESWGTRVASWPLTVLALSFIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTAKNRSSYKYDSLLLGPKNFSGILSLDLLQELLELQERLRHLQVWSHEAQRNISLQDICYAPLNPHNTSLTDCCVNSLLQYFQNNHTLLLLTANQTLNGQTSLVDWKDHFLYCANAPLTYKDGTALALSCIADYGAPVFPFLAVGGYQGTDYSEAEALIITFSINNYPADDPRMAHAKLWEEAFLKEMQSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSRVAVDSKATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVALLSLDSKRQEASRPDVVCCFSSRNLPPPKQKEGLLLCFFRKIYTPFLLHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEAGMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFIDWLTPSSSCCRIYTRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLSSDGQIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVLEEKLATEAAMVSEPSCPQYPFPADANTSDYVNYGFNPEFIPEINAASSSLPKSDQKF
What is the function of this protein?
Plays a major role in cholesterol homeostasis (PubMed:14976318, PubMed:15173162, PubMed:15671032).  Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:15173162, PubMed:15671032).  Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (PubMed:15173162).  May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032).  May be involved in caveolin trafficking from the plasma membrane (PubMed:15671032).  Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity).
What are the official names of this protein?
NPC1-like intracellular cholesterol transporter 1, Niemann-Pick C1-like protein 1, Npc1l1.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein.
Protein: GATC_CHLT3
Sequence: MSVTKQDVEYIATLARLSFSEDEKEKMTKELNTILHYVEKLNELDTEEVEALNNMNERHNVLRPDEIVASIENSKAIKNAPDSVERFFKVPKVIG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: MAK16_DANRE
Sequence: MQHDDVIWDLIGNKSFCSYKVKTKTQQFCRNEYNITGLCNRSSCPLANSQYATIREEKGQCFLYMKVIERAAFPSRMWEKVKLDRNYAKALEQIDENLIYWPRFIRHKCKQRLTKITQYLIRIRKLTLKRQRKLVPLSRKVERREKRREEKALIAAQLENAIEKELLDRLKQGTYGDIYNFPINAFDKAMEKQDEESESEEEEEEEDEEESGTREFIAEDEFEESDLSDFEELNNLKDSSDEEVNDEEESSEESEEESEEEEVKSKAKSKGKAPLKGPSRKKRAYVEIEYEQETEPAQKSKAT
What is the function of this protein?
Plays an essential role in early embryonic development.
What are the official names of this protein?
Protein MAK16 homolog, MAK16-like protein, Protein RBM13.
What is the protein family that this protein belongs to?
Belongs to the MAK16 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TRUB_RUEST
Sequence: MGRKRKGRDISGWLVVDKPAGLTSTAVVNKVRWAFDAKKAGHAGTLDPEATGVLAVALGEATKTVPFITDAMKAYTFTVTLGAATNTDDAEGEVIATSAERPTDDDIKEALLGFIGEIQQVPPKFSAVKIDGQRAYKLARDGEEVELSARPLWVEELVMLDRPDADHVVLEMTCGKGGYVRSIARDLGEKLGCLGHVRELRRIWSGPFDAEDGVTLEQIDALAKSPEIDQFLRPLEEGLADLPELKCTPQGATRLRNGNPGMVIASDVEYGEEAWASLEGKAVAVGTFKAGELHPSRVFNQD
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: CATA_ACIGI
Sequence: MMMNRQQIDSLVQQMNVATATGEVNLRVQQIVVRLLGDLFQAIEDLNMSQTELWKGLEYLTDAGQANELGLLAAGLGLEHYLDLRADEADAKAGITGGTPRTIEGPLYVAGAPESVGFARMDDGSESAHVDALIIEGNVTDTAGQIIPNAKVEIWHANSLGNYSFFDKSQSAFNLRRSIFTDTQGQYIAQTTMPVGYGCPPEGTTQALLNLLGRHGNRPSHVHYFVSAPGYRKLTTQFNIEGDKYLWDDFAFATRDGLIATALDVTDLAKIKQYNLNKAFKHIKFNFQLVQDADQVPLQRLIVVE
What are the official names of this protein?
Catechol 1,2-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the intradiol ring-cleavage dioxygenase family.