PharMolix/UniProtQA huggingface dataset:
Protein: TOIP1_MOUSE
Sequence: MAGERWQAEGPGEGWAIYVTPRAPIREGRRRLDPRNGDSSDAPAYGAHPSRRGRREVRFSEEPAEVYGDFEPRAAKERSPGGRRTPPEKFRPASAGEEVRESAYNLRSRPRRQRRAQEAEEMKTRRSARLEQHSQQPQLSPATSGRGLRDSPSSSEDREEDEPSSRPVTSQTASKKTLRTPEASVMNEDPISNLCRPPLRSPRLDSTYQTNGNTKTNEREATIVQQVNFFEEGETEDDLESSYSDITIRARSSDSLESRDEATPAAGNHPDSLRGLPHNQDFPAHENQPLLLTSGCQENPQEWVDRAVRMRSRMAYNNIQKSNFGNQSPSTSRPQSAIHHPNEPSVKIKWWLLGLVAILAVGLFWFFHTPAVETTAVQEFQNQMKQLQSKYQSQNEKLWKRGTTFLEKHLNSSLPRPQPAILLLTAAQDAAEVLKCLSEQIADAYSSFRSVRAIRIDGAGKAAQDSDLVKHEVDQELTDGFKNGQNAAVVHRFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEKTLEASLGLKEIEEKVRDFLKVKFTSSSTASSYNHMDPDKLNGLWSRISHLVLPVQPENTLKAGSCL
What is the function of this protein?
Required for nuclear membrane integrity.  Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane.  Binds to A- and B-type lamins.  Possible role in membrane attachment and assembly of the nuclear lamina.
What are the official names of this protein?
Torsin-1A-interacting protein 1, Lamina-associated polypeptide 1B, LAP1B.
What is the protein family that this protein belongs to?
Belongs to the TOR1AIP family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass membrane protein.
Protein: HUTG_STRPF
Sequence: MLEDYYPSTTSYYHSGIDDDLYTAKWGMVMTFLDLNDSSLTPFEGTHFALIGFKSDKGVYINNGRVGAVESPAAIRTQLAKFPWHLGNQVMVYDVGNIDGPNRSLEQLQNSLSKAIKRMCDLNLKPIVLGGGHETAYGHYLGLRQSLSSSDDLAVINMDAHFDLRPYDQTGPNSGTGFRQMFDDAVADKRLFKYFVLGIQEHNNNLFLFDFVAKSKGIQFLTGQDIYQMGHQKVCRAIDRFLEGQERVYLTIDMDCFSVGAAPGVSAIQSLGVDPNLAVLVLQHIAASGKLVGFDVVEVSPPHDIDNHTANLAATFIFYLVQIMAQHN
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: ENV_HV1MA
Sequence: MRVREIQRNYQNWWRWGMMLLGMLMTCSIAEDLWVTVYYGVPVWKEATTTLFCASDAKSYETEVHNIWATHACVPTDPNPQEIELENVTEGFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLNCTNVNGTAVNGTNAGSNRTNAELKMEIGEVKNCSFNITPVGSDKRQEYATFYNLDLVQIDDSDNSSYRLINCNTSVITQACPKVTFDPIPIHYCAPAGFAILKCNDKKFNGTEICKNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIMIRSENLTDNTKNIIVQLNETVTINCTRPGNNTRRGIHFGPGQALYTTGIVGDIRRAYCTINETEWDKTLQQVAVKLGSLLNKTKIIFNSSSGGDPEITTHSFNCRGEFFYCNTSKLFNSTWQNNGARLSNSTESTGSITLPCRIKQIINMWQKTGKAMYAPPIAGVINCLSNITGLILTRDGGNSSDNSDNETLRPGGGDMRDNWISELYKYKVVRIEPLGVAPTKAKRRVVEREKRAIGLGAMFLGFLGAAGSTMGAASLTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLQDQRLLGMWGCSGKHICTTFVPWNSSWSNRSLDDIWNNMTWMQWEKEISNYTGIIYNLIEESQIQQEKNEKELLELDKWASLWNWFSISKWLWYIRIFIIVVGGLIGLRIIFAVLSLVNRVRQGYSPLSLQTLLPTPRGPPDRPEGIEEEGGEQGRGRSIRLVNGFSALIWDDLRNLCLFSYHRLRDLLLIATRIVELLGRRGWEALKYLWNLLQYWGQELKNSAISLLNTTAIAVAECTDRVIEIGQRFGRAILHIPRRIRQGFERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: BTCA_NEOBT
Sequence: MANPPVTEWKQSEAIPAHVAQETGCFTTLPIRIHKNNSIADQATLESINDWKQHLDDGWESRSGSAISKVGNWCSFIFSEALPERLPCITYLANIGNIHDDATEDATLDEAITSHAQFSTALSLDTDDEPSLQEAKTRRFRHLVSNCVLEILSIDRDMGTRMIVSYQKKWLDVMEHLNYEGIESLEEYLEFRMLNGGMEPFWLMCQFGMGLNIPDAELAPTRHIFEPAEWALVLTNDYWSWGREYNASLTKGSRIVNSIELLSRLRNISYDEAKEVVRDLITTYEAEYERRVQDFLRENPSTQMYLRQFIEVAGLVVAGNHYWCANCPRHHAWKEQDQAVHAVDQLEEFPAVEAQSPSSATHTAAPQEDPPVTEAPSPISSPSSSSSAKPSSSSAADSSSCTSTSQHSPSETDSTPPSSLHLLKSPHPVDAPCTYMSSLPSKGVRSTLIHALNQWFQISSRNVTLIKEITSMLHNSSLILDDIQDQSPLRRGKPAAHTIFSTAQSINSSTYLFVRAMQMVSENFESSVQMSFLEILQRMHIGQSYDLHWRFHLQCPTEDEYFEMVDAKTGCMFEMLLLLMSSKSRHVKDHSFTSFIRTFGRYFQVRDDYMNLTSGEYTAGKGWCEDLDEGKLSYPLIECQKMAPASFTQIMGIFRAKQADTAQLSDETKKYVIELFRKSGVLDSTLDWIMEMERQLLMEVKRLEGVMGDSNPMLYVLLQTLSLNQ
What is the function of this protein?
Bifunctional terpene synthase; part of the gene cluster that mediates the biosynthesis of betaestacins (PubMed:29185768, Ref. 2).  The bifunctional terpene synthase btcA converts isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) into the sesterterpene betaestacin I (PubMed:29185768, Ref. 2).  The C-terminal prenyltransferase (PT) domain of btcA catalyzes formation of GFPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GFPP into betaestacin I (PubMed:29185768, Ref. 2).  The cytochrome P450 monooxygenase btcB is then responsible for the six-step oxidation of betaestacin I to yield betaestacin II (Ref. 2).  The roles of the cytochrome P450 monooxygenase btcC and the alpha-ketoglutarate-dependent dioxygenase btcD have not been identified yet (Probable).
What are the official names of this protein?
Sesterterpene synthase btcA, TS, Betaestacins biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the FPP/GGPP synthase family.
Protein: PLET1_ARATH
Sequence: MNSNNWLGFPLSPNNSSLPPHEYNLGLVSDHMDNPFQTQEWNMINPHGGGGDEGGEVPKVADFLGVSKPDENQSNHLVAYNDSDYYFHTNSLMPSVQSNDVVVAACDSNTPNNSSYHELQESAHNLQSLTLSMGTTAGNNVVDKASPSETTGDNASGGALAVVETATPRRALDTFGQRTSIYRGVTRHRWTGRYEAHLWDNSCRREGQSRKGRQVYLGGYDKEDKAARSYDLAALKYWGPSTTTNFPITNYEKEVEEMKHMTRQEFVAAIRRKSSGFSRGASMYRGVTRHHQHGRWQARIGRVAGNKDLYLGTFSTEEEAAEAYDIAAIKFRGLNAVTNFEINRYDVKAILESSTLPIGGGAAKRLKEAQALESSRKREAEMIALGSSFQYGGGSSTGSGSTSSRLQLQPYPLSIQQPLEPFLSLQNNDISHYNNNNAHDSSSFNHHSYIQTQLHLHQQTNNYLQQQSSQNSQQLYNAYLHSNPALLHGLVSTSIVDNNNNNGGSSGSYNTAAFLGNHGIGIGSSSTVGSTEEFPTVKTDYDMPSSDGTGGYSGWTSESVQGSNPGGVFTMWNE
What is the function of this protein?
Probably acts as a transcriptional activator.  Binds to the GCC-box pathogenesis-related promoter element.  May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).  Master regulator of basal/root fate.  Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis.  Modulates the root polar auxin transport by regulating the distribution of PIN genes.  Essential role in respecifying pattern and polarity in damaged roots.  Direct target of the transcriptional corepressor TPL.  Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs).
What are the official names of this protein?
AP2-like ethylene-responsive transcription factor PLT1, Protein AINTEGUMENTA-LIKE 3, Protein PLETHORA 1.
What is the protein family that this protein belongs to?
Belongs to the AP2/ERF transcription factor family. AP2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRUB_LISMF
Sequence: MNGIIPLWKERGMTSHDCVFKLRKILHTKKVGHTGTLDPEVEGVLPICIGRATKLAEYVTDEGKVYVAEITLGKSTTTEDATGETVMTKELADISADELQAALTKLTGKITQIPPMFSAVKVNGKKLYEYARAGIEVERPSRQVDIYSLTRLNGEATLNEANPTFQLEISCGKGTYIRTLAVMIGELLGYPAHMSKLERTRSGFFKKEDCLTLAEIDEMMQASDSSFLYPLEKGIESMAKLVIDEEIHAKVLNGGLLPKSLFIEVENEPRAALIFNDKLTAIYKPHPEKNELWKPEKVIELHQA
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: HXK2_EQUZE
Sequence: MIASHLLAYFFTELNHDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLAATTHPTASVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQKVEMENQIYAIPEDIMQGSGTQLFDHIAGCLANFMDKLQIKDKKLPLGFTFSFPCIQTKLDESFLVSWTKGFKSRGVEGRDVVTLIRKAIQRRGDFDIDIVAMVNDTVATMMTCGYDDQNCEIGLIVGMGSNACYMEEMRYIDTVEGDEGRMCINMEWGAFGDDGTLDDIRTEFDQEIDMGSLNPGQQLFEKMISGMYMGELVRLILVKMAKEELLFRGKLSPELLTTGRFETKDVSEIEGEKDGIQKAREVLVRLGMDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLQKTVRRLVPNCDIRFLCSEDGSGKGAAMVTAVAYRLAYQHRARLKTLEPLKLSREQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQDIMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNRLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNTEWGAFGDNGCLDDFCTEFDVAVDELSLNPGKQRFEKMMSGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALQQVRAILQHLGLESTCDDSIIVKEVCTVVAQRAAQLCGAGMAAVVDKIRENRGLDTLKVTVGVDGTLYKLHPHFAKVMRETVKDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
What is the function of this protein?
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively).  Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate.  Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis.
What are the official names of this protein?
Hexokinase-2, Hexokinase type II, HK II.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein. Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis.
Protein: VIRD4_BARQU
Sequence: MKYTKIQLALILMPIALGALTIFLVPHLLSFMINDLKANHVYWYVRSEPLLVLMLVATVSLCYTLSQKLHLRKAITLVSAVFFGITALYFIGGEIKRLTPYVGQQGITWSYALKFMDPMVVFGVICGVVLLVIQVMISSPPTSKVKRAKKGIFGDASWMNLKEAAKIFPANGQIVVGERYRVDQDGVCNIPFAPGNKTTWGKGGTAPLLTFNLDFGSTHMIFFAGSGGYKTTSTVVPTCLTYPGPIVCLDPSTEIAPMVRFARKKMGNRNVIVLDPNSLLTKNFNVLDWLLDDSVPRTQREANIVGFSKLLLTDKKSENSSAEYFSTQAHNLLTALLAHVIFSDEYEDSERNLKTLRAILSQSETAVVNQLRMIQETTPSPFIREMVGIFTEMADQTFSGVYTTASKDTQWLSLSNYADLVCGNDFSSSDIANGKTDVFLNLPASILNSYPAIGRVIIGAFLNAMVTADGKYKKRVLFVLDEVDLLGYMNILEEARDRGRKYGTSLMLFYQSSGQLVNHFGEAGARSWFESCSFVSYAAIKDLQTAKDISERCGQMTVEVTGTNKSRGLSLGKSSYNVNYQQRALILPHEIIQEMRQDEQIILMQGQPPLRCGRAIYFRRKEMLAAANKNRFAPQAKKN
What is the function of this protein?
Component of the type IV secretion system VirB/VirD4 which could be a major virulence determinant for subversion of human endothelial cell (HEC) function.
What are the official names of this protein?
Type IV secretion system-coupling protein VirD4.
What is the protein family that this protein belongs to?
Belongs to the VirD4/TraG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MDTL_SALPK
Sequence: MKRFLLCSFALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMATAMLFAGKIADQSGRKPVAIVGAIVFMMASLLCSRASEGSLFLSGRFLQGVGAGGCYVVAFAILRDTLDEHRRAKVLSLLNGITCIVPVLAPVMGHLIMLRFPWQSLFYTMSTMGIIVGLLSLFILRETRPARLAPRDLSRSSPAAESLVNRFFVSRLAITTLSVSVILTFVNASPVLLMEVMGFSRGDYAITMALTAGVSMVVSFSTPFALGLFKPRTLMLVSQGLFLTAGVTLSLAHTNTVTLFGLMLICAGFSVGFGVAMSQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAILGISAMNMLIGILIGCSIVSILLIFSVAPNRSVAEHEEIPYQSRS
What are the official names of this protein?
Multidrug resistance protein MdtL.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: H11_GLYBA
Sequence: MSDSAPEIETPVEEAPKAASPAKSPAKSPGRAKKAKKDGSDKPKKPKAIPTHPPVSEMVVNALKTLNEKGGSSVIAIKKFLVATYKVEIEKLLPFIKKFLKGAVLKGEVLQVKGTGASGSFKMPPPAKKVDRPESAPKKKATKTKTRVERKEKKVVAKKPKPAVEKKAAKPAAKKAAAKPAAKKAAAKPAAKKPAAKASPKKAAAKPKAKPTPKKSTPAKPKAAARKPAKKSK
What is the function of this protein?
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
What are the official names of this protein?
Histone H1-I.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: ACT2_PLAYO
Sequence: MPEESIALVVDNGSGMVKSGLAGDDAPKCVFPSIIGIPKMPNIMVGMEQKECYVGDEAQNKRGILTLKYPIEHGIVTNWDDMEKIWRHTFFNELRVSPEEHPVLLTEAPLNPKTNREKMTQIMFESFDVPAMYVSIQAILSLYASGRTTGIVLDSGDGVTHTVPIYEGYVLPHAINRTDMAGRDLTYYMMKLFTERGYTFTTTAEREIVRDIKEKLCYIALDYDEELKKSEERTEQVEEMYELPDGNLITVGSERFRCPEALFNPSLIGRECPGLHITAYQSIMKCDIDIRKELYNNIVLSGGTTMYNYIGERLTNEMTNLAPPSMKIKVIAPPERKYSVWIGGSILSSLSTFQKMWITKEEYDESGPSIVHRKCF
What is the function of this protein?
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm.  Polymerizes into longer and more stable actin filaments compared to ACT1/actin-1.  Has ATPase activity.  ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi.  ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin.  Plays an essential role in male gametocyte development in the mosquito midgut, functioning in several processes including male gametocyte egress from host erythrocytes, formation of a beating flagellum and relocalization of ACT1/actin-1 to the cytoplasm.  On the basal side of the mosquito midgut epithelium, required for the development of ookinetes into sporogonic oocysts.
What are the official names of this protein?
Actin-2, Actin II.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL3_CORGB
Sequence: MSENEIKGILGTKLGMTQIFDEENRVIPVTVVEAGPCVVSQIRTVETDGYNAIQIAYGEIDPRKVNQPLTGHFKKAGVTPRRHVTEIRMDDVSGYEVGQDVTVEIFNDIKFVDVTGTTKGKGYAGAMKRHGFAGQGAGHGNQAAHRRVGGIGAAATPGRIFKGKRMAGRMGNDRVTTQNLKVQKIDADANIILIKGAIPGNRGGIVTVKTAVKGGAHA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: GDPD1_ARATH
Sequence: MSLKAIHVSEVPSLDHFPENPSLICSSRKANNKFVVVGHRGHGMNMSQSPDLRFSALKENSILSFNAASKFPLDFIEFDVQVTRDGCPIIFHDDFIYSEEQGVVYEKRVTEVCLSEFMSYGPQRDTGKTGKPLLRKSKEGKIHKWSVATDDSFCTLQEAFEKVENPNLGFNIELKLDDNVFYSSDHLSRLLLPILQVVSDIGNDRTIIFSSFHPDAALLVRKLQTTYPVFFLTNGGTEMYHDTRRNSLEEAIKVCLEGGLQGIVSEVKGVFRNPALVNKIKESKLSLMTYGKLNNVAEAVYMQHLMGIEGVIVDHVEEITEAVREMMKPSNRDADGTKPKPNFSDRELSFLLKLIPELIQH
What is the function of this protein?
Hydrolyzes glycerolphosphoglycerol, glycerophosphocholine and glycerophosphoethanolamine in vitro.  May be involved in release of inorganic phosphate (Pi) from phospholipids during Pi starvation.
What are the official names of this protein?
Glycerophosphodiester phosphodiesterase GDPD1, chloroplastic, Glycerophosphodiester phosphodiesterase 1, AtGDPD1, Protein SENESCENCE-RELATED GENE 3.
What is the protein family that this protein belongs to?
Belongs to the glycerophosphoryl diester phosphodiesterase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CXA1_MACFA
Sequence: MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSIFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGKSDPYHATSGALSPTKDCGSQKYAYFNGCSSPTAPLSPMSPPGYKPVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNSKKLAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
What is the function of this protein?
Gap junction protein that acts as a regulator of bladder capacity.  A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph.  Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.  May play a role in cell growth inhibition through the regulation of NOV expression and localization.  Plays an essential role in gap junction communication in the ventricles (By similarity).
What are the official names of this protein?
Gap junction alpha-1 protein, Connexin-43, Cx43.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65.
Protein: VELB_MAGO7
Sequence: MNPGYSSTASQPGHNPSALPHDVHHALPAIGHPGSYHASMPQLPSIPPSMPPHYSDQYGMMQQPQDQPAPSSTTEGGAETKPSADAVARTQKKLQPHVGEQDGRKYRLDVVQQPKRARMCGFGDKDRRPITPPPCIRLIVTDAVTGKEIDCNEIEHTMYVLNVDLWSEDAQQEVNLVRHTSATPSISSTTPASFAQIDSTPPAFAQIPGTNREMPSYPQSQAYAPSVTPFAQQGGYGQQAISPVGPHYGMVANTYGGQGGYTYASPTDMHPHQLGSQVGPYGPRIFNGAPDMGMHQRMALQGTHQGAPPQGMFTRNLIGSLSASAFRLNDPQEKIGIWFVLQDLSVRTEGIFRLRFSYVNVGAPTRTPNGGPANQTSILNTGKAPILASCFSDAFQVYSAKKFPGVCESTPLSKCFAGQGIKIPIRKAEGGGKNNDDDDDY
What is the function of this protein?
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:24632440).  The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity).  Component of the VELB-VOSA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity).  The VELB-VOSA complex binds DNA through the DNA-binding domain of VOSA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity).  Involved in the regulation of the response to eactive oxygen species (ROS) stress (PubMed:24632440).
What are the official names of this protein?
Velvet complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the velvet family. VelB subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear localization is mediated by VEA (By similarity).
Protein: MENC_ECO27
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQETWEDAQSVLLAWVNNWLAGDCELPQMPSVAFGVSCALAELAETLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNLDYRHRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLDKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSLLPLVDVDALEQLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: PRIA_RICFE
Sequence: MRIAKILLPAAKLFPLDYLIPESLVLNIGDLVIVPFRSKELTGIVWEFATIPEASKLKTVKEKVPLDLSITSEVLELIKWLSSYYMSELGSIAKLVLPIDIAEKPIKVKEQKVNNSFVLPDLSEEQKQAVTILNESNKPTLIKGVTGSGKTEIYFHLIADYLVKGKQVLIMLPEIALSTQIINRFIERFGFEPIIWNSSVTKAQKKMILRGILSDKVKVVIGARSSLFLPFKNLGLVVIDEEHDDSYKQDDGILYNARDTAIVRGTFDKAQIVLCSATPSIETMYNIEIGKYQLVTLVNRYNNVDLPNIEIIDMTKEKLSKNSYLSKILIEAIKDNLDNKKQVLLFLNRRGYAPLMLCKACGHRFTCKFCSSWMVVHKATKKLECHHCGYQSKIFSSCPECLEDETLTICGPGIERIEEEAKALFPENKIAVISKDHAKNPERIAQLLHQMENLEIDILIGTQMITKGYHFPNLTLVGVIDADLGSNNADLRASERTFQLLHQVGGRAGRGDGKGVVYLQSYYPDNIIFSYVKAGDEDSFFANELEIRKSADMPPFSKTASVILSGSNESKILEIARAMVRIAPKANVKILGPASSLMSKLAGKYRYRILIIADKKFNLQKYLKFWLSLIKIPSFCHLKIDIDPKSFY
What is the function of this protein?
Involved in the restart of stalled replication forks.  Recognizes and binds the arrested nascent DNA chain at stalled replication forks.  It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
What are the official names of this protein?
Primosomal protein N', ATP-dependent helicase PriA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. PriA subfamily.
Protein: IXTPA_POLNA
Sequence: MKIVLASNNPGKLAELQALLAPLGLELLSQAELGIPEAEEPFRTFVENALAKARHASRLSGLSALADDAGLCVDAFGGLPGVDTAFYATRFGYAKGDNNNVRALLEQMAHLTQPGQRRAALVSTLVAVRSADDPEPLIASGRVAGEIALQPVGSNGFGFDPVMFIPEFAQTFAQLPVSVKNANSHRGKATAQMIALLRERWL
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: MCA1A_ASPOR
Sequence: MHHQQSSYGGGYPGQAYRQQQPNNAYGYGQPSPQPYGSHHNGYNSPQQNYGPPSGGHMYQQQSAYQNSYNQGGHGIPARPPDQPVSFGQGAPQEYAYRYSACTGTRKALLIGINYFNQKGQLRGCINDVKNMSTYLHENFGYPRENMVLLTDDQQNPKSQPTKANILRAMHWLVKDAKPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRQAGHIVDDEMHRIMVNPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMGSMVSTAVGFFKKATKGDEVYERNKQTKTSGADVIMWSGSKDDQTSQDAQIQGQATGAMSWAFISALRKNPQQSYVQLLNSIRDELSTKYTQKPQLSCSHPLGDLIDVPVLGSGFIWFWVLSIFQCQATK
What is the function of this protein?
Involved in cell death (apoptosis).
What are the official names of this protein?
Metacaspase-1A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.