PharMolix/UniProtQA huggingface dataset:
Protein: RF3_KLEP7
Sequence: MTLSPYLQEVAKRRTFAIISHPDAGKTTITEKVLLFGQAIQTAGTVKGRGSSQHAKSDWMEMEKQRGISITTSVMQFPYHDCLVNLLDTPGHEDFSEDTYRTLTAVDCCLMVIDAAKGVEDRTRKLMEVTRLRDTPILTFMNKLDRDIRDPMELLDEVENELKIGCAPITWPIGCGKLFKGVYHLYKDETYLYQTGKGHTIQEVRIVKGLNNPDLDAAVGEDLAQQLRDELELVQGASNEFDKDLFLAGEITPVFFGTALGNFGVDHMLDGLVEWAPAPMPRNTDTREVTATEEKFTGFVFKIQANMDPKHRDRVAFMRVVSGKYEKGMKLRQVRIGKDVVISDALTFMAGDRSHVEEAYPGDIIGLHNHGTIQIGDTFTQGEMMKFTGIPNFAPELFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPIANNDLIVGAVGVLQFDVVVARLKSEYNVEAIYESVNVATARWVESTDVKKFEEFKRKNEVQLALDGGDNLTYIAPTMVNLNLTQERYPDVVFRKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSTF1_RAT
Sequence: MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTSWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEVLFTQPNVELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNNEKKLALDMATNAACASLLKKKQATDGARTLSNAEDYLDDEDSD
What is the function of this protein?
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
What are the official names of this protein?
Osteoclast-stimulating factor 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NLP32_CAEEL
Sequence: MRQFNLLLVFCLIALTALPVFSFPNGLTMDSIDMEPMGAFDENGAADESPRVKRYGGWGGRGGWGRGGGRGYGGRGGGWGGRGGGWGRGGGGRGFYGGGRRGWGK
What is the function of this protein?
May have antimicrobial activity.
What are the official names of this protein?
Neuropeptide-like protein 32.
What is the protein family that this protein belongs to?
Belongs to the YARP (YGGW-amide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CG21_CANAL
Sequence: MPQVTKTNNENEFRLTRSKVQHQESISTIKNTTISNSQHKQQTQQQISSPPQVSVTSSEGVSHVNTRQYLGDVSNQYITNAKPTNKRKPLGGDNAPLQKQQHRPSRPIPIASDNNNNGSTSSSSNSSNNNNNDANRLASLAVPSRLPQKRQATESSTNLVEKLRVPQPEVGERSQSYHKKSRLIDYEWQDLDEEDSDDQLMVSEYVNEIFSYYYELETRMLPDPQYLFKQTLLKPRMRSILVDWLVEMHLKFKLLPESLFLAVNVMDRFMSVEVVQIDKLQLLATAALFTAAKYEEVFSPSVKNYAYFTDGSYTPEEVVQAEKYMLTILNFDLNYPNPMNFLRRISKADDYDVQSRTLGKYLLEITIVDYKFIGMRPSLCCASAMYLARLILGKLPVWNGNLIHYSGGYRISDMRECIELMFQYLIAPIEHDEFFKKYAMRKFMRASTLCRNWAKKFQASGRDLFDERLSTHRLTLEDDDEEEEIVVAEAEE
What is the function of this protein?
2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition.  G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.  Degradation is necessary for the cell to exit from mitosis.  Plays a role in morphogenesis by negatively regulating polarized growth.  Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1.  Also involved in the phosphorylation of CDC6 and CDC54.
What are the official names of this protein?
G2/mitotic-specific cyclin CLB2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
Protein: FABZ_CERS5
Sequence: MTEAAEATLSADIQLIQRIIPHRYPFLLVDRVRDIVPNQSAVGIKCVTMNEPQFTGHFPGLPIFPGVQIIEAMAQTAAVLVGVSLDLADKGAKVYFMGIDGAKFRRKVVPGDVLEMTVTVKRGGGKVWKFEGRASVDGELAAEAEFAAMLDIPKG
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSX2_MOUSE
Sequence: MTGKAGEALSKPKSETVAKSTSGGAPARCTGFGIQEILGLNKEPPSSHPRAALDGLAPGHLLAARSVLSPAGVGSMGLLGPGGLPGFYTQPTFLEVLSDPQSVHLQPLGRASGPLDTSQTASSDSEDVSSSDRKMSKSALNQTKKRKKRRHRTIFTSYQLEELEKAFNEAHYPDVYAREMLAMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESILKSAKDGIMDSCAPWLLGMHKKSLEAAAESGRKPEVERQALPKLDKMEQEERAPEAQAAISQEELRENSIAALRAKAQEHSTKVLGTVSGPDSLARNAEKPEEEDATEEDRPAEKLSPPQLEDMA
What is the function of this protein?
Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters (PubMed:17919464, PubMed:18539116).  Plays a significant role in the specification and morphogenesis of the sensory retina (PubMed:8630490).  May play a role in specification of V2a interneurons during spinal cord development (PubMed:18539116).  Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1 and MNX1 (PubMed:17919464, PubMed:27477290, PubMed:18539116).  Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1 (PubMed:19843539).  Acts as a negative transcriptional regulator of MITF (PubMed:23028343).  Represses SAG transcription by competitive inhibition of ISL1-LHX3 response elements (By similarity).  Binds to the photoreceptor conserved element-1 (PCE-1) in the promoter of rod photoreceptor arrestin SAG and acts as a transcriptional repressor (PubMed:16236706).  Involved in the development of retinal ganglion cells (RGCs) which leads to release of SHH by RGCs, promoting Hedgehog signaling and subsequent proliferation of retinal progenitor cells (PubMed:18417110).  Participates in the development of the cells of the inner nuclear layer, by promoting postnatal differentiation of bipolar cells with a comparable inhibition of rod cell differentiation (PubMed:8630490, PubMed:16547132).  May play a role in the maintenance of neural retina identity during development by regulation of canonical Wnt genes and CTNNB1 localization, suggesting a role in the regulation of canonical Wnt signaling (By similarity).
What are the official names of this protein?
Visual system homeobox 2, Ceh-10 homeodomain-containing homolog, Homeobox protein CHX10.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PAP3_BRACM
Sequence: MATLFTVTTTSRPFPANPSKTFSPSISLKPNALSFSLTHHRPPRPLRFSKIRSSLPSESDSEPEGGYSITDEWGEQPAEPESPPDNAPSAVSDEWGEKSESVPEESVTRFAESDPPTNEDEWEEREADDGVDKTWELKRCLADTVYGTELGFRAGSEVRAEVLEIVNQLEALNPTQAPVENPELLDGNWVLLYTAFSELLPLLAAGSTPLLKVKSISQSIDTKSLSIDNSTTLSSPFADFSFSATASFEVRTPSRIEVSFKEGTLKPPEIKSSVDLPESVGVFGQEINLSFLKQSLNPLQDVAANISRAISGQPPLKLPFPGNRGSSWLLTTYLDKDLRISRGDGGLFVLAREGSSLLEL
What are the official names of this protein?
Plastid lipid-associated protein 3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the PAP/fibrillin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RISB_CORK4
Sequence: MSGEGSPTITIEPGSAHGLRVAIVVSEWNRDITDELASQAQQAGETAGAEVTVIPVVGALEIPVVVKKATQTYDAVVALGCVIQGGTPHFDHVCNAVTYGLTKIAVETETPVGNGVLTCNTHEQAVDRAGGPTAHENKGAEAMIAAIHTAQTLKSMAAD
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: IF3_STRP6
Sequence: MKIIAKKDLFINDEIRVREVRLVGLEGEQLGIKPLSEAQSLADASNVDLVLIQPQAVPPVAKLMDYGKFKFEYQKKQKEQRKKQSVVTVKEVRLSPVIDKGDFETKLRNGRKFLEKGNKVKVSIRFKGRMITHKEIGAKVLADFAEATQDIAIIEQRAKMDGRQMFMQLAPISDKK
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_PSYCK
Sequence: MWGGRFSEATDSFVAAFTASVGFDQRFARHDIQGSIAHATMLRECGILEADDVATIIDGLHQVLREIEAGEFNWSIALEDVHMNVESRLTDIVGAVGKKLHTGRSRNDQVATDIRLWLREETDNIIALLVRLQSGLLDLAEQHTDTIMPGFTHLQTAQPVSFGHHVMAWFEMLYRDTERLVDARRRINQMPLGSAALAGTTFPIDRTITAELLGFEGICQNSLDAVSDRDFAIEFTSAASILMMHMSRMSEEIILWMSAQFNFVQIPDRFCTGSSIMPQKKNPDVPELVRGKAARVFGQLMTLLSLMKSQPLAYNKDNQEDKEPLFDCVDTLTGSLLAFADMLPNITPNKENMRAATMKGYATATDLADYLVRRGVAFRDAHEVVGNAVALGIAEGVDLSDLSLAQLQQFSDAIGEDVFEYLTLEGSLAARDHLGGTAPNQVKQAVSRGRTRLELFA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LSP_APIME
Sequence: VAPFPHGKLVTYKYIADVKAGVDPSLV
What is the function of this protein?
Unknown (it might play a role in lipid transport and/or storage protein metabolism during metamorphosis).
What are the official names of this protein?
Larval-specific very high density lipoprotein, VHDL.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: CFAT_PETHY
Sequence: MGNTDFHVTVKKKEVVAAVLPMHHEHWLPMSNLDLLLPPLDFGVFFCYKRSKINNDTKDDDETIKKALAETLVSFYALAGEVVFNSLGEPELLCNNRGVDFFHAYADIELNNLDLYHPDVSVHEKLIPIKKHGVLSVQVTGLKCGGIVVGCTFDHRVADAYSANMFLVAWAAIARKDNNINTVIPSFRRSLLNPRRPPQFDDSFIDSTYVFLSSPPKQPNDVLTSRVYYINSQEINLLQSQATRNGSKRSKLECFSAFLWKTIAEGGIDDSKRCKLGIVVDGRQRLRHDSSTTMKNYFGNVLSVPYTEASVGQLKQTPLGKVADLVHTCLDNVANEHHFPSLIDWVELHRPRQAIVKVYCKDECNDEAAIVVSSGLRFPLSQVNFGWGCPDFGSYIFPWGGQTGYVMPMPSPNKNGDWIVYMHLQKKHLDLVETRAPHIFHPLTACYLDLTATY
What is the function of this protein?
Acyltransferase involved in the biosynthesis of the floral volatile isoeugenol, and which promotes the formation of phenylacetaldehyde, phenylethyl alcohol, phenyl-ethyl acetate, phenylethyl benzoate and benzyl acetate (PubMed:17241449).  Catalyzes the acetylation of coniferyl alcohol to produce coniferyl acetate (PubMed:17241449).  Also active toward 1-octanol, cinnamyl alcohol, geraniol and sinapyl alcohol (PubMed:17241449).
What are the official names of this protein?
Coniferyl alcohol acyltransferase, PhCFAT, (E)-cinnamyl alcohol acyltransferase, (E)-sinapoyl alcohol acyltransferase, Geraniol acyltransferase, Octan-1-ol acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
Protein: FABV_BURP1
Sequence: MIIKPRVRGFICVTTHPAGCAASVREQIAYVARRGPIERGPKKVLVIGASTGYGLAARIAAAFGAGAATLGVFFERAPADAKPGTAGWYNSAAFHDEAAARGLQATSVNGDAFSDEIKHKTIDAIRRDLGQVDLVVYSAAAPRRTHPKTGVTHQSTLKPIGHAVRLRGIDTDNEAIKETLLQPATPDEIADTVAVMGGEDWRMWIDALDAAGVLADGAKTTAFTYLGEQVTHDIYWNGSIGEAKKDLDRTVLALRGKLAARGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKARGTHEGCIEQVDGLLRDSLYGAQPHVDAEGRLRADRLELDPAVQARVLELWDQVTDDNLYTLTDFAGYKAEFLRLFGFGIDGVDYDAPVEPNVRIPNLIE
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: VAMP7_MOUSE
Sequence: MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFSFLNEVKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKSLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCMKNIKLTIIIIIVSIVFIYIIVSLLCGGFTWPNCVKK
What is the function of this protein?
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome.  Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion.  Required for calcium regulated lysosomal exocytosis.  Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi.  Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells.  Required for focal exocytosis of late endocytic vesicles during phagosome formation.
What are the official names of this protein?
Vesicle-associated membrane protein 7, VAMP-7, Synaptobrevin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein. Synapse, synaptosome. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).
Protein: RNPH_PSEMY
Sequence: MKRPSGRAADQLRSIRITRNYTKHAEGSVLVEFGDTKVICTVSVESGVPRFLKGQGQGWLTAEYGMLPRATGERNQREASRGKQGGRTLEIQRLIGRSLRAALDMSKLGENTLYVDCDVIQADGGTRTASITGAMVALIDALKVLKKRGSLKGEPLKQMIAAVSVGIYQGEPVLDLDYLEDSAAETDLNVVMTNAGGFIEVQGTAEGAPFQPEEFNAMLALAQKGMNEIFELQKAALVD
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: EAMA_ECOLI
Sequence: MSRKDGVLALLVVVVWGLNFVVIKVGLHNMPPLMLAGLRFMLVAFPAIFFVARPKVPLNLLLGYGLTISFAQFAFLFCAINFGMPAGLASLVLQAQAFFTIMLGAFTFGERLHGKQLAGIALAIFGVLVLIEDSLNGQHVAMLGFMLTLAAAFSWACGNIFNKKIMSHSTRPAVMSLVIWSALIPIIPFFVASLILDGSATMIHSLVTIDMTTILSLMYLAFVATIVGYGIWGTLLGRYETWRVAPLSLLVPVVGLASAALLLDERLTGLQFLGAVLIMTGLYINVFGLRWRKAVKVGS
What is the function of this protein?
May be an export pump for cysteine and other metabolites of the cysteine pathway (such as N-acetyl-L-serine (NAS) and O-acetyl-L-serine (OAS)), and for other amino acids and their metabolites.
What are the official names of this protein?
Probable amino-acid metabolite efflux pump.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MATK_PURTR
Sequence: MEEFQGYLELDRSQQHDFLYPLIFREYIYALAHDHGLNRSILLDNVGYDNKSSLLIIKRLISRMYQQNHLIISANDSNPPQNWGYNKNLYCQMISEGFAVIVEIPFSLRLVSSLEGTETVKSYNLRSIHSIFPFLEDKFPHLNYGSDVLIPYPIHLEILVQTLRYWAKDPSSLHLLRLFLHDYYNLNSLITPNKSIFSKSNPRLFLLLYNSYVCEYESILLFLRNQSSHLQFTSSWIFFERIHFYEKIKYPVEEVFANDFPAILWFFKDPFMHYVRYQGKSILASKDTPLLMNKWKYYLVNLWQCHFYVWSQPGRIDINQLSKHSLDFLGYLSSIRPNLSVVRSQMLENSFIMDNAMKKFDTLVPIIPLIGSLAKVKFCNALGHPISKSTWADSSDFDIIDRFVRICRNLSHYYSGSSKKKSLYQIKYILRLSCVKTLARKHKSTVRTFLKRLGSKLLEEFFTEEEQILSLIFPRASSTLKRFYRERIWYLDIFCINDLVNHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GPDA_SALSV
Sequence: MNQSNASMTVIGAGSYGTALAITLARNGHQVVLWGHDPKHIATLEHDRCNVAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFSDVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDETFADDLQQLLHCGKSFRVYINADFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLTEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVKGAQDKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKEELSRH
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_PONAB
Sequence: MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASATVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTHYSGKEEPFGYMGMVWAMVSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNTKWSAAILWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFITMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSAGSFISLTAVMLMIFMIWEAFASKRKVPMVEQPSTSLEWLYGCPPPYHTFEEPVYMKPE
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ILVC_SHIBS
Sequence: MANYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVVNLTPDKQHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNAQLRDVNEAIRCHAIEQVGKKLRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: TPC2_MOUSE
Sequence: MAAEEQPLLGRDRGSGQVHSGAAADQELCIDQAVVFIEDAIKYRSIYHRMDAGSLWLYRWYYSNVCQRVLGFIIFLILILAFVEVPSSFTKTADVRYRSQPWQPPCGLTETIEAFCLLAFLVDLSVKGYLVGQAQLQQNLWLLAYFMVLVVSVVDWIVSLSLACEEPLRMRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTIIGMLLFTIGEKDEAQDQERLAYFRNLPEALTSLLVLLTTSNNPDVMIPAYTQNRAFALFFIVFTLIGSLFLMNLLTAIIYNQFRGYLMKSLQTSLFRRRLGARAAYEVLASRAGPAGTTPELVGVNPETFLPVLQKTQLNKTHKQAIMQKVQSYEGRPMLADEFQKLFDEVDKGLAKERPLKPQYQSPFLQTAQFIFSHHYFDYLGNLVALGNLLSICVFLVLDSDLLPGERDDFVLGILDYIFILYYLLELLFKVFALGLPGYLSYHSNVFDGLLTIILLVSEICTLAVYRLPHSGWKPEQYGPLSLWDMTRLMNTLIVFRFLRIIPNIKPMAEVANTILGLIPNLRAFGGILVVAYYVFAMIGINLFRGVIVPPGNSSLVPDNNSAVCGSFEQLGYWPNNFDDFAAALITLWNVMVVNNWQVILEAYKRYAGPWSMVYFVLWWLVSSVIWINLFLALLLENFLHRWDPQGHKQLLVGTKQMSVELMFRDILEEPKEEELMEKLHKHPHLHLCR
What is the function of this protein?
(Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm.
What are the official names of this protein?
Two pore channel protein 2, Two pore calcium channel protein 2, Voltage-dependent calcium channel protein TPC2.
What is the protein family that this protein belongs to?
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Only the acidic lysosomal fraction is sensitive to NAADP.
Protein: CPR3_CAEEL
Sequence: MLKVYFLALFLAGCSAFVLDEIRGINIGQSPQKVLVDHVNTVQTSWVAEHNEISEFEMKFKVMDVKFAEPLEKDSDVASELFVRGEIVPEPLPDTFDAREKWPDCNTIKLIRNQATCGSCWAFGAAEVISDRVCIQSNGTQQPVISVEDILSCCGTTCGYGCKGGYSIEALRFWASSGAVTGGDYGGHGCMPYSFAPCTKNCPESTTPSCKTTCQSSYKTEEYKKDKHYGASAYKVTTTKSVTEIQTEIYHYGPVEASYKVYEDFYHYKSGVYHYTSGKLVGGHAVKIIGWGVENGVDYWLIANSWGTSFGEKGFFKIRRGTNECQIEGNVVAGIAKLGTHSETYEDDGGAATSCSFIMCTLMVLTYYFV
What are the official names of this protein?
Cathepsin B-like cysteine proteinase 3, Cysteine protease-related 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: ARGC_RIPO1
Sequence: MGESERIPVGIIGASGYGGVQLVRLLLEHPQVEIAYLGGKGSAGKPYWDLYPHLSHLVNLTVEPIDLEVVASRCQVVFLGLPNGLACDMAPQLIAKGCKVLDLSADYRFRDLQTYTAWYNKDRSDTETAAKAVYGLPELYRTEIQSASLIGCPGCYPTASLMALSPLLKQGLILPETAIIDAKSGTSGGGRQEKIHLLLAEAEGSLGAYGVAKHRHTPEIEQVCSDLAGHEVKVQFTPHLIPMVRGILSTVYASLRDPGLVRDDILTIYSAFYRSSPFVKILPHGIYPQTKWAWGTNLCYIGIETDPRTDRVIVLSAIDNLMKGQAGQAVQCLNLMMGWEETLGLPQLSFYP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.