PharMolix/UniProtQA huggingface dataset:
Protein: SLD7_VANPO
Sequence: MFEKLAVLKVKLGDRHSDIVLRDIQLWRKPLDGDNDNGLDRSISNVKEINYLKGEFLQYIDINKIPLWLRSSEHFSNLLICFTTSTTTNAFFESKLKYINRGIVIEVNSAAAAAAANNYQHRYLIFYKNGHNVEFIPIDLSLKELFDNKIASLNADTENVTEGKEKKKSSSIDKILMQSQKKVFVQTNKVMESLQISEKRQKFNETLSKLILSGLRLRGIPNTQSGFQKIYKMTFDTTEFAHREELVKLSHNTIHEIPFEDIQETVETLLKLFTKS
What is the function of this protein?
Required for the proper initiation of DNA replication.  Required for mitochondrial morphology (By similarity).
What are the official names of this protein?
Mitochondrial morphogenesis protein SLD7.
What is the protein family that this protein belongs to?
Belongs to the SLD7 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle pole.
Protein: MSRAB_NEIGO
Sequence: MKHRTFFSLCAKFGCLLALGACSPKIVDAGTATVPHTLSTLKTADNRPASVYLKKDKPTLIKFWASWCPLCLSELGQAEKWAQDAKFSSANLITVASPGFLHEKKDGEFQKWYAGLNYPKLPVVTDNGGTIAQNLNISVYPSWALIGKDGDVQRIVKGSINEAQALALIRNPNADLGSLKHSFYKPDTQKKDSAIMNTRTIYLAGGCFWGLEAYFQRIDGVVDAVSGYANGNTENPSYEDVSYRHTGHAETVKVTYDADKLSLDDILQYYFRVVDPTSLNKQGNDTGTQYRSGVYYTDPAEKAVIAAALKREQQKYQLPLVVENEPLKNFYDAEEYHQDYLIKNPNGYCHIDIRKADEPLPGKTKAAPQGKGFDAATYKKPSDAELKRTLTEEQYQVTQNSATEYAFSHEYDHLFKPGIYVDVVSGEPLFSSADKYDSGCGWPSFTRPIDAKSVTEHDDFSFNMRRTEVRSRAADSHLGHVFPDGPRDKGGLRYCINGASLKFIPLEQMDAAGYGALKGEVK
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (By similarity).  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA/MsrB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
Protein: RTCA_THEON
Sequence: MSMIVIDGSYGEGGGQILRTSVALSVITGKPVRIYNIRANRPNPGLRPQHMHGILALKELSGAKVKGAQVGSTVLEFYPGRARPRHIRVPIKTAGSVTLVLQALLPAMAFIGGSFEITGGTDVPWSPPVDYLRHVTLFALEKMGLRAEIEIKRRGHYPKGGGLVVGRVEPWEERKPLVALEWRHIELFGGISHATNLPEHVASRQAKAARERLSEFYDVPINIYEEVSRSLGPGSGIVVWAETDVLRLGGDALGKRGKPAEAVGREAADELLEQLTSRAAVDRFLGDQLVPFLAFAGGEIKVAEITNHLVTNVWVVEQFLGKIFEVEGEVGEPGRVRVVG
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAE2_MYCBO
Sequence: MGWSNGPPSWAEMERVLNGKPRHAGVPAFDADGDVPRSRKRGAYQPPGRERVGSSVAYAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARTERPDPPGPHLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYDFDALTEAAGGHWHILTGCRKGHVRQALSQGGPAAAQRALADLVDRFTPSRVSIELTHHGHPLDDERNAALAGLAPRFGVGIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAGWLAPLGGAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARERYGPPKSAPRAYSQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILCQGRGSAANSAVCYALGVTAVDPVANELLFERFLSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWSKQVSHWTGQADDVDGIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWARMANRSVLQWDKDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGSKRSTERMRRLRGRFYDGMRALHGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVAVHGPCVNASLAHATCENAGTEVRLGLGAVRYLGAELAEKLVAERTANGPFTSLPDLTSRVQLSVPQVEALATAGALGCFGMSRREALWAAGAAATGRPDRLPGVGSSSHIPALPGMSELELAAADVWATGVSPDSYPTQFLRADLDAMGVLPAERLGSVSDGDRVLIAGAVTHRQRPATAQGVTFINLEDETGMVNVLCTPGVWARHRKLAHTAPALLIRGQVQNASGAITVVAERMGRLTLAVGARSRDFR
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CMOB_YERPN
Sequence: MIEFGDFYRLIAKGPLSPWLDTLPAQLSAWQRESLHGKFKTWFNAVEHLPQLTPTTLDLHSGVRAEMSPPISAGQREGMENMLRALMPWRKGPFSLYGLDIDTEWRSDWKWQRVLPHISPLAGRTILDVGCGSGYHLWRMIGEGAHLAVGIDPMQLFLCQFEAIRKLLGGDQRAHVLPLGIEQLPELAAFDTVFSMGVLYHRRSPLDHLYQLKNQLVTDGELVLETLVVEGDSQQVLVPGDRYAQMRNVYFIPSAPALKAWLEKCGFVDVRIADMAVTTTEEQRRTDWMTSESLAEFLDPHDHSKTVEGYPAPLRAVLIARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: HMCS1_BLAGE
Sequence: MWPSDVGIVALELIFPSQYVDQVDLEVYDNVSAGKYTVGLGQARMGFCTDREDINSLCLTVVSRLMERWSIPYSQIGRLEVGTETLLDKSKSVKTVLMQLFKDNTDIEGVDTVNACYGGTSALFNAISWVESSSWDGRYALVVAGDIAVYAKGSARPTGGAGAVAMLVGANAPLVFDRGVRSSHMQHAYDFYKPDLSSLYPTVDGKLSIQCYLSALDHCYQLYCSKIQKQLGEKFDIERLDAVLFHAPYCKLVQKSLARLVLNDFVRASEEERTTKYSSLEALKGVKLEDTYFDREVEKAVMTYSKNMFEEKTKPSLLLANQVGNMYTPSLYGGLVSLLVSKSAQELAGKRVALFSYGSGLASSMFSLRISSDASAKSSLQRLVSNLSHIKPQLDLRHKVSPEEFAQTMETREHNHHKAPYTPEGSIDVLFPGTWYLESVDSLYRRSYKQVPG
What is the function of this protein?
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
What are the official names of this protein?
Hydroxymethylglutaryl-CoA synthase 1, HMG-CoA synthase 1, 3-hydroxy-3-methylglutaryl coenzyme A synthase 1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Protein: SECY2_LEUGG
Sequence: MKGENINNIHLVLKKMLWTSLIVFIFLIGRNILIPGVDAKQLARFLNNQYLLQIVNGTTGGDLSRMSLFALGLGPWMSATILWRVLTLIKRFDLKKIPIERTFLFKIAIAIIIGFIQSIAIISNIDINPKISIFAQTQFGAMATISLIMVSGAVFLVWLSNMNEILGIGGPTVLILASMIINWPTNVSLYILENVRSSLDINSVILMLVIMISIVFLVLLTVVVQRAQRQIPIRRILVNNNFYQQSYLPIQINPAGGMPLMYSMTLLVLPQYILQAVHYWLPNNVLVENGLDNIAITKPLGVTAYIIILFALSIGFAFININPDQIAEDLQQNSDYIDNVEPGDATREYITEIVFRLSFVGALYMSLIAGFPLYFGIIDKQYTQYALTAGSIIILVNLVINIIDQMKALLTKNNYSALFFE
What is the function of this protein?
Part of the accessory SecA2/SecY2 system specifically required for export of possible cell wall proteins.  The central subunit of a protein translocation channel.
What are the official names of this protein?
Accessory Sec system protein translocase subunit SecY2.
What is the protein family that this protein belongs to?
Belongs to the SecY/SEC61-alpha family. SecY2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HIS4_PHOPR
Sequence: MIIPALDLINGQVVRLFQGDYGQVTEYKVDPAEQFKLYNQAGANWLHLVDLTGAKDTSARQLDLISQLLASTPANIQIGGGVRSEKDVSDLLEAGAQRVVIGSTAVKQPEMVKGWMEKYGPEHIVLALDVNIDKDGNRNVAISGWQEDSGVSIEALLDDFLTVGLKHVLCTDISRDGTLAGSNVELYVDLCAQYPQVQFQSSGGIGDLNDIAALKGSGVAGVIVGRALLDGKFTAEDAFQCWNS
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL1_NITWN
Sequence: MATGKRLKKSREGIDRNKLYPIADAIRMVKERATSKFDETIEIAMNLGVDPRHADQMVRGVVTLPNGTGRTLRVGVFARGAKAEEAKAAGADVVGAEDLVETVQGGTIAFDRCIATPDMMPLVGRLGKVLGPRGMMPNPKIGTVTMDVAGAVKGAKGGSVEFRVEKAGIVQAGIGKASFSAEKLVENVKALADAVAKAKPAGAKGTYVQRIAVSSTMGPGVKVEPGTVLG
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: TM14C_PONAB
Sequence: MQDTGSVVPLHWFGFGYAALVASGGIIGYAKAGSVPSLAAGLLFGSLASLGAYQLSQDPRNVWVFLATSGTLAGIMGMRFYHSGKFMPAGLIAGASLLMVAKVGVSMFNRPH
What is the function of this protein?
Required for normal heme biosynthesis.
What are the official names of this protein?
Transmembrane protein 14C.
What is the protein family that this protein belongs to?
Belongs to the TMEM14 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: ACKA_YERPP
Sequence: MSSKLVLVLNCGSSSLKFAIIDATNGEEHISGLAECFHLPEARIKWKVDGGKQEAALGAGAAHSEALNFIVNTILAQKPALSAQLTAIGHRIVHGGEKFTSSVIVTEDVIQGIKDSIPFAPLHNPAHLIGIAEALKSFPNLADKNVAVFDTAFHQTMPEESYLYALPYSLYKDHGIRRYGAHGTSHFYVSQEAAKILNKPLEELNVITCHLGNGGSVTAVRNGKCVDTSMGLTPLEGLVMGTRSGDLDPAIIFHLHDAMGMSVDQINTLLTKESGLLGLTEVTSDCRYVEDNYATKADAKRAMDVFCHRLAKYIGSYTALMDGRLDAVVFTGGIGENAAMVRELTLDKLGLLGFEIDHERNMAARFGKSGTITKDSSRLALVIPTNEELVIAQDAARLTA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATSK_PSEPU
Sequence: MSNAALATAPHALELDVHPVAGRIGAEIRGVKLSPDLDAATVEAIQAALVRHKVIFFRGQTHLDDQSQEGFAKLLGEPVAHPTVPVVDGTRYLLQLDGAQGQRANSWHTDVTFVEAYPKASILRSVVAPASGGDTVWANTAAAYQELPEPLRELADKLWAVHSNEYDYASLKPDIDPAKLERHRKVFTSTVYETEHPVVRVHPISGERALQLGHFVKRIKGYSLADSQHLFAVLQGHVTRLENTVRWRWEAGDVAIWDNRATQHYAVDDYGTQPRIVRRVTLAGEVPVGVDGQLSRTTRKG
What is the function of this protein?
Catalyzes the oxygenolytic cleavage of 2-ethylhexyl sulfate (2-EHS) in the presence of alpha-ketoglutarate to yield 2-ethyl-hexanal and succinate, the decarboxylated form of alpha-ketoglutarate.  It can accept a wide range of alpha-keto acids including 2-oxo-valerate, 2-oxo-adipate, 2-oxo-octanoate, 3-methyl-2-oxo-butyrate, oxaloacetate-alpha-ketoadipate, and alpha-ketooctanoate.  It can catalyze the cleavage of medium-chain alkyl sulfate esters such as butylsulfate, pentylsulfate, hexylsulfate, heptylsulfate, octylsulfate, nonylsulfate, decylsulfate and sodium dodecyl sulfate (SDS).
What are the official names of this protein?
Alpha-ketoglutarate-dependent sulfate ester dioxygenase, Alkylsulfatase, Type II alkyl sulfatase.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
Protein: MEND_SERP5
Sequence: MSTSVFNRRWAALLLEALARHGVRHVCIAPGSRSTPLTLAAAANKSFICHTHFDERGLGHLALGLAKASREPVAVIVTSGTAAANLYPSLIEAGLTGERLVFLTADRPPELINCGANQAIRQNGLYASHPALSIDLPRPTTDIPARWLVSTVDSAMARLQHGALHINCPFAEPLYGGDEQQYADWSATLGDWWQGNHPWLREVDPHQVLKQPDWFFWRQKRGVIVAGRMSADEGEHLAQWAEMLGWPLIGDVLSQTGQPLPCADLWLAQPQAQKRLAEAQLVVQFGSSLTGKRLLQWQEQCQPQEYWLIDDLPGRLDPAHHRGRRIRSSVAQWLELHPAQPRTPWADELTMLADNALDAVSGHLVNRFGEAQLAHRLPELLPENGQLFLGNSLIVRLIDALTRLPAGYPVFSNRGASGIDGLISTAAGVQRATAKPTLAVVGDLSALYDLNALALLRQCSAPTVLIVVNNNGGQIFSLLPTPEEDRQRFYCMPQNVEFSHAAAMFQLAYARPENWGQLLQAVEQGWRHGGATLIELQVPPSDGAQTLQHLVQQMTEQ
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: PIGV_DROME
Sequence: MTEKVTKLALASRLIVLLVQLVANGALPEHKPDVFRMPVSSDQNASWIDKVIKRCLGGLRHWDGEYFLHIAENLYSYENTLAFYPLYPVVVRHVGQAVEAIGISLSQESILLVVAVALNFWLFCESANLLFQLTQVLFNDLNKSWNAALIYCFNPATIFFTAAYSETFFAYSSLHLMLECSKPTGSFRYLRLGTALAACLLCRSNGLITLGYPLYFFGRQLLLKNKEPNTCMQLTQMTLTILGAIGILHTYYFYIYRLYCLPNTRPNHPQHIVDYAVERKYLLSGQGSEGSPWCQYTLPFPYTYVQSHYWDVGFLRYYKWKQLPNFLLALPMLSFMHWHCYDYMQHLAKAVWAKLTPSGFKELIRDHTTFPFVLHAAILTLVCTVYVHIQVSTRLLASATPVFYWFAADHMPKTLAQLKLRSKAGALFVWCTTYSLVGTVLFSNNYPWT
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly.  Required for the GPI-mediated endoplasmic reticulum exit and proper targeting to the cell surface of chp.  Required for GPI-mediated membrane attachment of chp, qsm and Cont.  Essential for microvillar stability in the rhabdomere.
What are the official names of this protein?
GPI mannosyltransferase 2, GPI mannosyltransferase II, GPI-MT-II.
What is the protein family that this protein belongs to?
Belongs to the PIGV family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DUS29_DANRE
Sequence: MSSAQAEDEQDYETPSCYELQKHFTHGGVAYTHVNEVWPGVYIGNEETARDRYKLQTLGITHILNAAEGEWNSVDTGAEYYKDMQIHYYGVTAEDTPTFNISQYFYSAAEYIQQTLSDPHNKLLLHCVMGRSRSATLFLAFLMLQQRMSLLQAVEQLAHRRHICPNWGFLKQLRELDTHLQEERRRTHT
What is the function of this protein?
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity).  Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity).
What are the official names of this protein?
Dual specificity phosphatase 29, Dual specificity phosphatase DUPD1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TIM21_KLULA
Sequence: MFCQFISRPAQSLSGKFSSKTLCLPLIASPVRIKHTVQGYSTFNAQQNAGNKQQKKKIPLWPRIRAFTTFTFSGILVIGATGLAGVVIYLIGAELFSPSGDTQIFNRAVSKVENDEVARRLLKCNDTETSTERLKAYGEILTDDRWTRNRPISSTRRIDKEGKEHYLMRFHVESKQKMGIVHVEAKESDVNYQPDFVSMYLDIPGEKRHYLIKPKLSIVKPKGFLGVNWGPKRD
What is the function of this protein?
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.  Required to keep the TOM and the TIM23 complexes in close contact.  At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM21.
What is the protein family that this protein belongs to?
Belongs to the TIM21 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: GSTCD_DROME
Sequence: MDQLYLEIEISTQKETTIYTGVSSFLALFTYKFLKDPKNVRVNFVSTKIEGGKIALRSSQLKKELTDRHITCRDAASLPAIQDLKLPIYEKDGNTFIAGTCAVCRELIARQPNEELKKLLGFKGSCLLAPSEASIWTKFCEVDLVAVVSKLHSGQVLEFVPQEVVRFEQHMNEPVRMHNIYKQAREQANQTENGGKVKRRERVQIKCTTPKEELLIEHRFAEGISFTIADIILYPLLRIVFQHCGQMLPHFPLTSTWFSEIDSFGDKCARVLRDLYVPQAIKTPPGELGIPDCEATSLYKADPKRYKPRNRIYTSQLELEAALSKLSSLQLQFNSDSEHTYGQQLIDWEQIEPTHAKSSALPKERLERKRQQLENLANAVVSLAQPGDRIVDFCSGTGHLAILLALKLPNCTIIVMENKAFSLLQAQKRSNELGLTNCVFYQCNIDYFVGGFKIGASLHACGTATDIVLQQCRRAKAHFVCCPCCYGSLQPMPHISYPLSKAFQKVLDTKDYLYIAHSADQAHEMGTTNCKPETTLQGLHCMSVVDTDRLLQAEEAGYQVILTRLKPEQCTPKNHLLVGRFVKQN
What are the official names of this protein?
Glutathione S-transferase C-terminal domain-containing protein homolog.
What is the protein family that this protein belongs to?
Belongs to the GSTCD family.
Protein: HDA_SHIDS
Sequence: MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEHLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: FAEC_ECOLX
Sequence: MKKAFLLACVFFLTGGGVSHAAVQKTIFSADVVASVCHVVVDADSTGNSGRLTFGTYRKSTGASVPPRDFTVRLYESGATVQGCSAFLAGQVATLDFGNPGQLDAAGVVTRGAGDGIRVDVRAVDAQADYRGRLTQDNHSVKYPVDFAAKGQFRFRAQPVFPADVKAGEYSGALTFVVTYQ
What is the function of this protein?
Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0. 5-1. 5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs.
What are the official names of this protein?
K88 fimbrial protein A.
What are the subcellular locations of this protein?
Fimbrium. Note=Predominantly located at the tip of the fimbriae.
Protein: ARMC2_HUMAN
Sequence: MLSPNDKMLGKLDPFYQPSVSKQKTSAEIISEARNALRTVRTQRPFTPQEAQRKLFGPASSRTSENRPPSSFSLHASSFESSDSRPISGTRLSPLELKPKVPASPTREEDSCFSFPKPPVDPAKIRRVSNARARLFRAASQRALLPDRSLPPSDSKKTVESKETVMMGDSMVKINGIYLTKSNAICHLKSHPLQLTDDGGFSEIKEQEMFKGTTSLPSHLKNGGDQGKRHARASSCPSSSDLSRLQTKAVPKADLQEEDAEIEVDEVFWNTRIVPILRELEKEENIETVCAACTQLHHALEEGNMLGNKFKGRSILLKTLCKLVDVGSDSLSLKLAKIILALKVSRKNLLNVCKLIFKISRNEKNDSLIQNDSILESLLEVLRSEDLQTNMEAFLYCMGSIKFISGNLGFLNEMISKGAVEILINLIKQINENIKKCGTFLPNSGHLLVQVTATLRNLVDSSLVRSKFLNISALPQLCTAMEQYKGDKDVCTNIARIFSKLTSYRDCCTALASYSRCYALFLNLINKYQKKQDLVVRVVFILGNLTAKNNQAREQFSKEKGSIQTLLSLFQTFHQLDLHSQKPVGQRGEQHRAQRPPSEAEDVLIKLTRVLANIAIHPGVGPVLAANPGIVGLLLTTLEYKSLDDCEELVINATATINNLSYYQVKNSIIQDKKLYIAELLLKLLVSNNMDGILEAVRVFGNLSQDHDVCDFIVQNNVHRFMMALLDAQHQDICFSACGVLLNLTVDKDKRVILKEGGGIKKLVDCLRDLGPTDWQLACLVCKTLWNFSENITNASSCFGNEDTNTLLLLLSSFLDEELALDGSFDPDLKNYHKLHWETEFKPVAQQLLNRIQRHHTFLEPLPIPSF
What is the function of this protein?
Required for sperm flagellum axoneme organization and function (By similarity).  Involved in axonemal central pair complex assembly and/or stability (By similarity).
What are the official names of this protein?
Armadillo repeat-containing protein 2.
Protein: COPD4_ORYSJ
Sequence: MTFLYITCYCVAFNRKLLVFMQMEKGKHNKGGYSSISGPQVIEKSFNDMSISCTGFGSGSGLGGLNTDTDTFTSRPKGRTSGGTTGAGKGIGMKLGNTKKTNQFLESLKAEGEVIMEDFQPCSLQSRSSPLPPSDPVTVAVEEKLNVAVKRDGGVNNFDVQGTLALLVLNDADGLILLQIESQDIPGLSFKTHPNINKDLFNSQQILGAKDPIRPFPSGQNETPLVKWRIQGMNESSLPLSVNCWPSILGNETYVNIEYEASEMFDLHSVIISIPLPALREAPRVRQIDGEWKYDSRNSVLEWSIILIDQSNRSGSMEFVVPPADPSMFYPISVGFSASNTFSNVKVTGIRPLNEGSNPPKYSQRVRLVADNYQVV
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit delta-4, Delta-coat protein 4, Delta-COP 4.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: MU151_SCHPO
Sequence: MSLVAYDSEEEEQTSLVNENNDIKGRSEEPHWKIPNSPKAEVDTELEKKIKQFIKLKAKGIHFHTRLSENENFRNPKLLDNLQDFLDIKEPRGTMISKDMWDPTDFHKNVYASALSKSQDEMIARRENYQKHDRTEIKFQTSQHPK
What is the function of this protein?
Has a role in meiosis.
What are the official names of this protein?
Meiotically up-regulated gene 151 protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZNRF3_MOUSE
Sequence: MRPRSGGRPGAPGRRRRRLRRGPRGRRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRFSRAGAMLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSGSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPGAVCVETSNLTRGRQPRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQNLYSPQTPTYVRGYPPLHLDHTLAPHRCSLEHRAYSPAHPFRRPKFSSRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQTIPSVTPRGQSRAFPPSGASSLLFPTMVHVAPPTHVESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSNSSGQCRCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRGPAVHLEGSPPPEELPAGHSQSAGRGEPWLGPASPSGDQLSTCSLEMNYSSNSSLEPRGPNSSTSEVGLEVSPGAALDLRRTWKGGPEGPSCACCFEPQPFPPGSGIETSAGGSSLFLGPRLLEDCNPPSGEPQLGSSQGLYGLHSDHYPRTDGVKYEGLPCCFYEEKQVAHSAGRGNGCYTEDYSVSVQYTLTEEPPPSCYAGPRDLSQRIPIIPEDVDCDLGLPQDCHGMHNHSPWGGALSLDVPRLHWSLGTTREEEQAPCYQAEVQPGCSPEEAGASRASLSSAPQDTQESHALAAEASGPGSGPGIGTGA
What is the function of this protein?
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6.  Acts on both canonical and non-canonical Wnt signaling pathway.  Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959, PubMed:22895187).  Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase ZNRF3, RING-type E3 ubiquitin transferase ZNRF3, Zinc/RING finger protein 3.
What is the protein family that this protein belongs to?
Belongs to the ZNRF3 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: YOQF_BACSU
Sequence: MKFAPMDKVKFKTASHLNKLRTLKKRVPELDDPLLGECWEFEEDGLRQFDWEENYEFVARPKHFNWD
What are the official names of this protein?
SPbeta prophage-derived uncharacterized protein YoqF.
Protein: CCMA_PSESM
Sequence: MTPAPPFLQATALACERDWRVLFENLDLHLCAGDMLQVSGPNGSGKTSLLRLLCGLMQPTAGQVLLNGQVLGRQRAPGCDLLWLGHAPALKDLLTPLENLAWLCALHQPAGADAIGHALNAVGLAGFEDVPCHTLSAGQQRRVALARLHLPGPSLWILDEPFTALDQQGIAQLENHLADHCEQGGMVVITTHHTLSRLPAGYRSIDLAKGSA
What is the function of this protein?
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KDSB_PARL1
Sequence: MANLAQPAAKELAGHPLVVIPARMASTRLPGKPLADICGTPMIVQVWRRAMEAGVGRVVVAAAEKEIADAVREAGGEAVLTDPDLPSGSDRVWQAVCEVDPEGHHTVILNVQGDLPTLDPALIRTAYEALVRPGADISTLAATITVEEERTNPNVVKAVASFGEGRLARALYFTRATAPWGEGPLYHHIGLYGYRREALARFVALPPSPLEVREKLEQLRALEAGMAIEVALVDTVPLGVDTPADLEKARAALARRSV
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.