PharMolix/UniProtQA huggingface dataset:
Protein: RSMC_AERS4
Sequence: MSSPISAVSQMLERNQALFVGKRLLVCGTLEDDYPRQLAELASSLTVFTTDYCYYRSQQATLGDAILFDHQLGGAPRFDALLLLMPKAKAEAQYLLAMMTPLLEAGADLFLAGENRGGINGADKLLAPYGNKPVKRDSARRCSLYHGELSKPVIPFELDAWFSRYECKAGDTELTVLALPGVFSADELDPGSQMLLAAVPPMTGELLDFGCGAGVIGSVLAKRNPGLEVKMVDISALALESSRRTLAINGLQGQVQASDVYSDITGKFDHIVSNPPFHAGLKTFYAATETFLAKAPEYLSANGGLTIVANAFLRYQPILETHFKRTDIISSDAKFKVYLSKV
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLCNE_CRIGR
Sequence: MEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPAFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKCKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFPPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERISLILQMCVEAAAEAVKLNCRILGVGISTGGRVNPQEGIVLHSTKLIQEWNSVDLRTPLSDTLHLPVWVDNDGNCAAMAERKFGQGKGQENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGHLVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEPVGALHLIQAAKLGNVKAQNILRTAGTALGLGVVNILHTMDPSLVILSGVLASHYIHIVKDVIRQQASSSVQDVDVVVSDLVDPALLGAASMVLDYTTRRIH
What is the function of this protein?
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids.  Required for normal sialylation in hematopoietic cells.  Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.  Plays an essential role in early development (By similarity).
What are the official names of this protein?
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ROK (NagC/XylR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_RICAE
Sequence: MANLNKRPDWIKVKAPNSTEYYNTKDLIKNLRLNTVCEEAACPNIGECWSKKHTTVMILGSVCTRACRFCNVKTGRPDLLDPYEPQRLAEAVQKLNLKHVVITSVDRDDLEDGGASHFAECISEIRKSSPNTTIEILTPDFLRKEGAAEIIANAKPDVFNHNVETVPSLYKTIRPGARYYNSLSLLHNIKKLSPEIFTKSGMMVGLGEEINEVVQVIDDLREAKVDFLTIGQYLQPTKNHAEVAKYVTPEEFKYLERVAKTKGFLMVSASPLTRSSYHADEDFQKLKENYQQKLMS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_KARMD
Sequence: MDKQSKFRIKTFFKKIIFFLIIFCFFYFFNFIKKTKKITHTTQDKFFELLSKNKINKFIVLNKKKVSFTLNEKKSHLDSNNYNFFSKLHLSRYEFEIGDLQLFQKKIDFYKELYEINPNFEFKNYKIYTVLNFFYDYGFFLMIIIICWIFIFRKIASRSSESEFKFKIGKSKAKLYYYNNITFKDVAGLEGPKEEIKEIVDFLKSPNKYTKLGGKIPKGALLIGPPGTGKTLLAKAVAGEAQVPFFSLSGSDFVEMFVGVGASRVRDLFYIAKLKSPSIIFIDEIDAIGRARIKNNIPGGNDERENTLNKLLTEMDGFSTKTNVIVLAATNRYDVLDDALLRSGRFDRTIFIDLPSLKERKDIMKVHLKKIKFSKSIDLDFISRQIPGFSGADISNICNEAALLAARRNKVKVETKDFIDTIYRRIGGIEKKNILIKKNEKKRIAYHETGHAIISWIIEYAHSVFQITITPRGQSLGAAWYIPEERQITTEDQMKDEICTLLGGRAAEYLIFNNKSTGALNDLERITKQAQSMVKFFGLSSLGNISYFDSTGRNDFSLEKAYSEKTSEIIDKEINKIIKEQYKRALEILKKNYDKLIFLAEKLFKKEVLFKEDFASILD
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
Protein: SECB_BURTA
Sequence: MSDVENQPFFNIQRIYLKDLSLEQPNSPAIFLEQEMPAVEVEVDVKAERLADTVYEIVVAGTVTAKVREKVAFLVEAKQAGIFDIRNIPAEQIDPLCGIACPTILFPYLRSNIADSITRAGFPPIHLAEINFQALYEQRLAEIAQQQGGAPNGTTLN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF11_OLEA2
Sequence: MAKEEAITVTGVVQEALPNAMFRVELENGHEVLAHISGKMRKFHIRVLPGDKVSVELSPYDLTRGRITFRPR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1 1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZCRB1_MOUSE
Sequence: MSGGLAPSKSTVYVSNLPFSLTNNDLYRIFSKYGKVVKVTIMKDKDTRKSKGVAFILFLDKDSALNCTRAINNKQLFGRVIKASIAIDNGRAAEFIRRRNYFDKSKCYECGESGHLSYACPKNMLGEREPPKKKEKKKKRKLPEPEEEIEEVEVSEEEGEDPALDSLSQAIAFQQAKIEEEQSKWRPNPGGPSTSDDSRRPRIKKSAYFSDEEELSD
What are the official names of this protein?
Zinc finger CCHC-type and RNA-binding motif-containing protein 1, MADP-1, U11/U12 small nuclear ribonucleoprotein 31 kDa protein, U11/U12 snRNP 31 kDa protein.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: GCH1_SULIY
Sequence: MQKTELDDQKLVEEIARRIREILELLGENPEREGLKETPERVAKALLEMTSGLRTPPPQIKVFSLGEDGEVYEKNQIVLIKDVNFSSLCEHHMLPIIGKIHVAYIVSNSGKVAGFSKIIRIVNYYSSRLQIQERLVEQIADAIMNSEIKPKGVMVIGNAIHMCSYVRGVKDKEAKLVSVAYRGLFKTNRALQNHVFRLLDNANKVNLL
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: DAPB_HISS2
Sequence: MTLKIGIVGSGGRMGRQLIQAVYHTEGVELGAAFERVGSSLVGTDAGELAGIGRIGIKVTDNLTQEKGNFDILIDFTRPEGTIQHLAFCVEQHKNIVIGTTGFDDQSKQAIQQAAQNIAIVFASNYSVGVNLVFKLLEKAAKVMGDYCDIEIIEAHHRHKVDAPSGTALSMGEHIAKTLGRDLKTHGVFSREGITGERKPDEIGFSTIRAADVVGEHTVWFADIGERVEISHKASSRMTFANGAVRAAKWLSTKQEGLFDMTDVLDLNNL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YM31A_YEAST
Sequence: MIKRETRLRAKILGINANASSHNGECGNASSEITTVWIIEHMKNNLVTKWLNRVLHTSLKMVWYVYRGFNNSLGVCIICLPCNVLSSSQSHLLIAKESALPVSDSRCYYIL
What are the official names of this protein?
Putative uncharacterized membrane protein YML031C-A.
Protein: SELO_BURVG
Sequence: MSFSRSAADPADTLPDLAATLAAPGDDAFVALGDAFHTRLPAAPLPAPYVVGFSAEVAQLLGLPPSLAAHAQFAELFAGNPTRDWPAHALPYASVYSGHQFGVWAGQLGDGRALTIGELPGSDGRRYELQLKGGGRTPYSRMGDGRAVLRSSIREYLCSEAMHHLGIPTTRALTVIGSDQPVVREEIETSAVVTRVSESFVRFGHFEHFFSNDRPDLLRRLADHVIERFYPACREADDPYLALLEAAMLRTADMVAQWQAVGFCHGVMNTDNMSILGVTIDYGPFGFVDAFDANHICNHSDTSGRYAYRMQPRIAHWNCYCLAQALLPLIGLQHGIGDDDARAERAVDDAQAVLAKFPERFGPALERAMRAKLGLELEREHDAELANQLLETMHASHADFTLTFRRLAQLSKHDASRDAPVRDLFIDRAAFDAWANLYRARLSEETRDDAARAAAMNRVNPKYVLRNHLAEVAIRRAKDKDFSEVERLAQILRRPFDEQPEHEPYAALPPDWAGSLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: MA7D2_PONAB
Sequence: MERGGGGGFGTGSRPEGTARGTCLPGKIAEPGAVRTSQPNYRPQGMEGFLKSGERQRLAKERREEREKCLAAREQQILEKQKRAKLQYEKQMEERWRKLEEQRQREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGHDGESENTPPPPLGLAASTLPPDAGTTAAAAESTNACDKLSTSTMSLPKPTEPPMSKRLSSSTVAISYSPDRAPLGPLNPSYKSSPTRNIEKKKATSTSTSGAGDVGKEALAGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVISKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQAAGPQGEDALEKHVVDKHASEKHAAATGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKKQEEEEKREAGEEAKRKAEEELLLKEKQEQEKPEKEKQEKAMIEKQKEAAEAKAREVAEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVSPQVKKEDPKMGVQPAVCVEKKTKLVVPNKMEINGLNTCQEINGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDSTEEVQSMDVSPVSKEELISIPEFSPVSEMIPGVPLDQNGTGNARALQDLLDFTGPPTFPKRSSENLSLDDCNKNLIEGFNSPGQETPLNTFC
What are the official names of this protein?
MAP7 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the MAP7 family.
Protein: TEA_DROME
Sequence: MYPVSFAAFQKLIVNLSEIASELKTANGDNRTLVEWSRWYYKEFYRNPSIRARFPVKVAPCPRRTRDNLLKVPEPGGISQNDVANVAAAGPSQVEQPEVLVEGSQLTTLAETAKSHDAVEGVAVECKPSGSESPDVIVNVERCGAFIFPVSFDVFLQCINKMLLFKKIVRSIEHCLVLLSDDERRLLTLQRFYNRFYMYPEKRSPTNIFNATTEIPLEKLLESGKPLDKKAVKTVAELTAMKSLTKNSIVSFEVFKKNMANLSDIVEQMRQLDANYASKDVQECALDYYLAFYITPRIRYKYAYKLKPCTSTFKACMLSILGKDIAEKLRKSLPQLANPSPGLDSRRPNTSYITESKGSLGSQNTSGSSQIQTSPSMEVAHEPSEGLSQLATLSPENCAAGAISTTEGLSSSHNTLETFENQANLRNDANKLSRCMPALASPERHLHSSKAPEKSSEVLSPQVKPHQSKEVAEEQSDRAPQLEIPPSGFEVPMSKTPESPASKTRASDETPAKPEEITDSTDVYETSFVTDVEVDLKKHGRFIFPVSLETFRQYINYDEIIRAILVNNHIKDEHQLSKLISDPSHPQCKKFFRQFYNKFYARNDVRQRFKYKFNCPNPKMLAKLKQKAKPLDEKALFTMNRTDNAKAVNESKSQVPFTPKTTTENCPPNPISLEMFKRHVSNLDDIVNEMQKCDEYKEKSKEEVIQDYYEGFYSGPDMREKFECRFKPCPSKKIRQLLSFPPKNKELPPKNPNCQVACTTENLSDESCLQSSRNVVRETQNITEEKPIAEHESIPSTRTPSSNDDKPGEECPPYPVSLELFKSHVSNLDDIANNMQKCVEYRGKSKDEVIRDYYKGFYSGPEMREKFACRFKPCTGHILQQLLSYPGKNVNDCLQETDCLATCTTRTPLKESCLQSKSEMSLPVRRNALEILMKRKRTKVAKEAISSKPMTTQNTSQFQPEPFPEDALVVPEDVTTNQGTQPLELQHELEVTEPIKDYIQLNAERLYELSSKLKIGWNYTAHNFLDKLFKGINCPVTQAFLEEQYKRYSVSTGHIVANTIAAEENEPQLSSNSVDIESVCTAQTTATDTQATEMHTIPKALDQSSEPTKESSSVNLNNNLESPAKIKMIHAESSNNSRNSTNRPNTEIEAGSTKILEDGARVTTEGNSENENSSVEKKENQFLLERAKEIFFAEGSKDHNLKYLICTSEGLMRTIWRILYQLDLQEFSYYTSIHDGEDLYKSEDNLHLCFRHVVDHGNWPVNLCVLLPRLKHLLHSKGVQLDRLNLSKISPKIFSPWELGTYSDFDQIVAQEYIHRTGEEIEDVVKLCQEREKLYACCWAHNQWLPRAPQIANETLNAELGEVEPVIERILLKKICGVKDGDENKPTEIVSIPSSPSTVCSRISTQPAEDKLSQQPSQLNSLNFVDVTGVELASQVPQMVVDPLVSNQIEETSQVPETQYDAPASLQMASVKQEPISFLNNQRAFCDSEKCQWEHINPEEQTIDLDSTESDGPSLSCFAIQNQNSEDQIHFILEDSVHAENHDYVKKTEVPKSTDPAQLGTNVNTLSVRSMPACQVSVIPKKRQAASPRLNSKRMKLMNDKVPQLRHEFQPLPMGVKVVQSKALILPDSQNIRTSQTAKTKPTESPPHHQVNITPSQEFAVGNTLLECSELQGLLDSNDVNDGKVNKEDHPVSGSACTSKRLAASSPQSSVIYRDLELFSFYKSLTLEQIIKYRIEGPLPGATYQKALVKINDKLCNVRGPLISSLFPYLSSTLRSDLELVLHDLGEFFYKRSWPAHTDATVDFRKRVLFVFMNLSPRFAPFSIKFDNESREWGTCIEANVGDKSLDQRDTTFNAEELIKPNILNSIEQLKCKLVT
What is the function of this protein?
Protects telomeres from fusion.  Likely to function as a component of the MTV complex along with moi and ver.  The complex binds single-stranded DNA in a sequence-independent manner and can protect it from DNA degradation.
What are the official names of this protein?
Protein telomere ends associated.
What are the subcellular locations of this protein?
Chromosome, telomere.
Protein: RIBD1_BUCAP
Sequence: MKDRFYMTRAIKLSKLGEFTTSPNPNVGCVIVQNKKIVGEGWHKKYGENHAEINALNMAGEKAKGSTAYITLEPCNHFGKTPPCCDAIIQSGIKNVIISSLDPNPKVSGKGVLYLRKKGISVKIGLMSKESQKYNKGFFKRMRTGLP
What are the official names of this protein?
Diaminohydroxyphosphoribosylamino-pyrimidine deaminase, DRAP deaminase, Riboflavin-specific deaminase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: TRPB_VIBC3
Sequence: MAKLNAYFGEFGGQFVPQILVPALDQLEQAFIDAQQDDAFRAEFMSLLQEYAGRPTALTLTQNITKGTKTKLYLKREDLLHGGAHKTNQVLGQALLAKRMGKHEIIAETGAGQHGVATALACALLGLKCRVYMGAKDVERQSPNVFRMRLMGATVIPVHSGSATLKDACNEALRDWSASYETAHYLLGTAAGPHPFPTIVREFQRIIGEETKNQILAREGRLPDAVIACVGGGSNAIGMFADFIEEESVRLIGIEPAGKGIHTHQHGAPLKHGKTGIFFGMKAPLMQDEHGQVEESYSVSAGLDFPSVGPQHAYLNAIGRAEYESITDDEALDAFQALARNEGIIPALESSHALAHAIKMAYAEPDKEQLLVVNLSGRGDKDIFTVHKLLEDKGAL
What is the function of this protein?
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
What are the official names of this protein?
Tryptophan synthase beta chain.
What is the protein family that this protein belongs to?
Belongs to the TrpB family.
Protein: LEUD_LEPBL
Sequence: MKPFTVLNGIAALLDRPNVDTDQIIPKQFLRKIERTGFGVHLFHDWRYLDDAGTKLNPEFSLNQERYKGASILLTRDNFGCGSSREHAPWALEDYGFRSIIAPSYADIFFNNCFKNGMLPVVLKSEEVEELFRSVSGNVGAKLQIDLDKQTVTGPTGKVYTFEVDSFRKYCLYNGLDDIGLTLKQGSKIGAFEKKQKEVEPWLYVI
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TPSD2_PICAB
Sequence: MALLSSSLSSQIPTGSHPLTHTQCIPHFSTTINAGISAGKPRSFYLRWGKGSNKIIACVGEGTTSLPYQSAEKTDSLSAPTLVKREFPPGFWKDHVIDSLTSSHKVSAAEEKRMETLISEIKNIFRSMGYGETNPSAYDTAWVARIPAVDGSEHPEFPETLEWILQNQLKDGSWGEGFYFLAYDRILATLACIITLTLWRTGETQIRKGIEFFKTQAGKIEDEADSHRPSGFEIVFPAMLKEAKVLGLDLPYELPFIKQIIEKREAKLERLPTNILYALPTTLLYSLEGLQEIVDWEKIIKLQSKDGSFLTSPASTAAVFMRTGNKKCLEFLNFVLKKFGNHVPCHYPLDLFERLWAVDTVERLGIDHHFKEEIKDALDYVYSHWDERGIGWARENPIPDIDDTAMGLRILRLHGYNVSSDVLKTFRDENGEFFCFLGQTQRGVTDMLNVNRCSHVAFPGETIMQEAKLCTERYLRNALEDVGAFDKWALKKNIRGEVEYALKYPWHRSMPRLEARSYIEHYGPNDVWLGKTMYMMPYISNLKYLELAKLDFNHVQSLHQKELRDLRRWWKSSGLSELKFTRERVTEIYFSAASFIFEPEFATCRDVYTKISIFTVILDDLYDAHGTLDNLELFSEGVKRWDLSLVDRMPQDMKICFTVLYNTVNEIAVEGRKRQGRDVLGYIRNVLEILLAAHTKEAEWSAARYVPSFDEYIENASVSISLGTLVLISVLFTGEILTDDVLSKIGRGSRFLQLMGLTGRLVNDTKTYEAERGQGEVASAVQCYMKEHPEISEEEALKHVYTVMENALDELNREFVNNRDVPDSCRRLVFETARIMQLFYMEGDGLTLSHEMEIKEHVKNCLFQPVA
What is the function of this protein?
Involved in defensive oleoresin formation in conifers in response to insect attack or other injury (By similarity).  Involved in diterpene (C20) olefins biosynthesis.  Bifunctional enzyme that catalyzes two sequential cyclizations of geranylgeranyl diphosphate (GGPP) to isopimara-7,15-diene.
What are the official names of this protein?
Bifunctional isopimaradiene synthase, chloroplastic, Diterpene synthase, PaTPS-Iso.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsd subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PURA_SORMK
Sequence: MATIILGSQWGDEGKGKLTDILCPKAQICARAAGGHNAGHSIVANGVEYDFHLLPSGLVNPNCMNLIGSSVVFHVPSFFSELSKLEEKGLTDVHNRILVSDRCHVDFDLHAAVDGLEEVELGDRKIGTTGRGIGPSYSTKMARSGVRIHEIFNEEIFERKLRQLANGYKKRFGDLLKYDVEEEIARFKEYRVKLAPYTVDAVQYMKQAQDRGYKILIEGANALMLDIDYGTYPYVTSSNTGLGGIITGLSINPTKIDNIIGVVKAYTTRVGGGPFKTEDLEEAGTKLQDIGREWGVSTGRKRRCGWLDLVVLKYSTAINNYTALNLTKLDILDTFETIKVAVAYKDPQTGEEVEYFPADLGILDSLEVVYKELPGWNKPITDCKTYYDLPKEARAYVEFIEEFVGVPICYIGTGPKREDMIVRKASAIKE
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTAA_GRABC
Sequence: MSDHIRAASSPSRHGSEHGWQHAVTPQQRNRILVATWMFTLCFMILVMVMLGGATRLTGSGLSIMEWAPLMGTLPPTSQTEWERLYALYQKIPQYALVNHGFGLDGFKHIFWLEWTHRLWGRLIGLVLLLPLIFLAVTRRIERSLIPRLILIFVLGGLQGAVGWFMVASGFFPDSTAVSPYRLVVHLSFALLLYSALLWTALSVLNPEPRPLPGTVGLRRMSAVTLGLVCITIIAGGFVAGIHAGLDYNTFPLMDGRLVPEGYGEGHRAMFENIPTVQFDHRLLATLTALTALLTGLIGFRRGGNARRAVLPLMVAVILQYALGIATLLSVVAVPVAVVHQGMAVLLLTAAIVTLHSLRGAGRTASINAPASSH
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AACUP_ASPA1
Sequence: MPAPAATQTATLNKFIDGWKGWTPDGFLASWSDDCAQVTLPFSSGVPPRTRAITEKLFPKLMSILTNFQLTVHNVIHEPAESKAVIYAITTADSPFGPYKNEHACFVWFDESGESVNRIEEMFDGVFMKGFLPKLEAYIKGQEEA
What is the function of this protein?
Monooxygenase; part of the gene cluster that mediates the biosynthesis of the tetrahydroxanthone dimer secalonic acid D (PubMed:30996871, PubMed:33891392).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase AacuL (Probable).  The atrochrysone carboxyl ACP thioesterase AacuM then breaks the thioester bond and releases the atrochrysone carboxylic acid from AacuL (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase AacuI, and oxidized by the anthrone oxygenase AacuG to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by a yet unidentified oxidoreductase (Probable).  A-ring reduction by the short chain dehydrogenase AacuN, dehydration by the scytalone dehydratase-like protein AacuK and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:33891392).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) AacuH then yields monodictyphenone (PubMed:33891392).  Monodictyphenone is transformed into compounds with the tetrahydroxanthone skeleton via methylesterification by the methyltransferase AacuQ, followed by the action of the flavin-dependent monooxygenase AacuC, the isomerase AacuP, and the short chain dehydrogenase/reductase AacuF or AacuD (PubMed:33891392).  AacuF and AacuD should accept the same compound as a substrate but perform the ketoreduction with a different stereoselectivity, thus yielding blennolides B and A, respectively (PubMed:33891392).  In the final step of the biosynthesis, the cytochrome P450 monooxygenase AacuE accepts blennolide B and/or blennolide A to conduct the dimerization reaction to furnish the tetrahydroxanthone dimers, secalonic acids D, B, and F (PubMed:33891392).
What are the official names of this protein?
Monooxygenase AacuP, Secalonic acid biosynthesis cluster protein P.
What is the protein family that this protein belongs to?
Belongs to the avfA family.
Protein: YIA1_MYCTX
Sequence: MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEIARLLGVAARRRCVSGCARRRSMPAHGPGPRPKNPLR
What are the official names of this protein?
Insertion element IS986 uncharacterized 8.2 kDa protein, ORFA1.
Protein: TRHY_SHEEP
Sequence: MSPLLRSIFNITKIFNQYASHDCDGTTLSKKDLKNLLEREFGEILRKPHDPETVDLVLELQDRDRDGLIDFHEFLAIVFKVAAACYYALGQASGLNEKEAKCERKGNPLQDRRREDQRRFEPQDRQLEERRLKRQELEELAEEEELREKQVRREQRLQRREQEEYGGEEELQQRPKGRELEELLNREQRFERQEQRERQRLQVEQQQRQRGELRERQEEVQLQKRETQELQRERLEEEQQLQKQKRGLEERLLEQERREQELRRKEQERREQQLRQEQEEATQEEISERGESRTSRCQWQLESEADARQRKVYSRPHRQEQQSRRQEQELLERQQEQQISEEVQSLQEDQGRQRLKQEQRYDQNWRWQLEEESQRRRYTLYAKPAQREQVREEEQLRLKEEKLQREKRRQERERQYREVELQREEERLQREEEQLQREEREKRRRQEREKQYLEKVELWEEEQLQREEREKRRQEREKQYLEKVELREEEQLQRQEREKRRQERERQYLEKVELQEEEQLQREEREKRRQERERQYLEKVELQEEEQLQRQEREKRRQEREKQYLEKVELQEEEQLQRQERQKRRQEREKQYLEKVELQEEEQLQRQEREKRRQERERQYLEKVELQEEEQVQRQEREKRRQERERQYLEKELQRQEERLQEEEQLLREEREKRRQERERQYLEKVELQEEEQLQREEREKRRQERERQYLEKEELQRQEERLQREKEQLQREDREKRRQVRERKYLEEELQQEEDRLQREKQLLREDREKRQYLEKVELQREEEQLQREKRRQERERQYREEELLREEERLHRKEQQLQREECEKRRRQELERQLEEEELQRLDRKRQFRDDDQHQNEVRNSRVYSKHRENKEKSRQLDDSWVRESQFQQDLRPLQDEQEEKREREQEWRSRQKRDSQFPAEQLLEREQQKETERRDRKFREEEQLLKGQREEKIRYLEEDRKFREEEQQLRRLEREQQLRQERDRKFREELSRQERDRKFREEEQLLQEREEQLRRQERDRKFREEEQLLQEREEQLRRQERDRKFREEEQLLQEREEQLRRQERDRKFREEEQQLRLLEREQQLRQERNRKFREEQLLREREEQLRLQEGEPQLRQKRDRKFHEEEQLLQEREEQLRRQERDRKFREEAQILKEREEQLRRQERDRKFREEEQLLQEREELRRQEREPQLRQERDRKFREEEQLLQEREKLRRQEREPQLRQERDRKFHEEEQLLQEREEQLRRQERDRKFREEAQLLQEREEQLRRQERDRKFREEEQLLQEREEQLRRQERDRKFREEEQLLQEREEQLRRQERDRKFREEEQLLKESEEQLRRQERDRKFHEKEHLLREREEQQLRRQELEGVFSQEEQLRRAEQEEEQRRQRQRDRKFLEEEQSLQREREEEKRRVQEQDRKFLEQEEQLHREEQEELRRRQQLDQQYRAEEQFAREEKRRRQEQELRQEEQRRRQERERKFREEEQLRRQQQEEQKRRQERDVQQSRRQVWEEDKGRRQVLEAGKRQFASAPVRSSPLYEYIQEQRSQYRP
What is the function of this protein?
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis.  It later becomes cross-linked to KIF by isodipeptide bonds.  It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network.  It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation.
What are the official names of this protein?
Trichohyalin.
What is the protein family that this protein belongs to?
Belongs to the S100-fused protein family.
Protein: YPRR_ECOLX
Sequence: MHLPPQAAGPYRSRFSYNTQTQPPEKPRSSAELKPQSPSLITEKRPRPGPKGRNRVAFNYECCNYFIIAVSLLAGSSQYTLVSGPDGPLTRRYAPTSGKPSSGPLRPRTEALSWLKAGMVWQGWGWVR
What are the official names of this protein?
Uncharacterized protein repA4.
Protein: KGUA_STRP3
Sequence: MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALMREYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNPFKAK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL20_BURMA
Sequence: MPRVKRGVTARARHKKIINLAKGYRGRRNNVYRIAKQAVMRAGQYAYRDRRNKKRVFRALWITRINAAVRQHDMTYSVFINGLKKASIELDRKVLADMAVFDKAAFAAIVKQVKAAVAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: BIOZ_BRUA2
Sequence: MTVCSSRLAGFGHAVPDRRVENAEIEAQLGLETGWIERRTGIRCRRWAMPDETLSHLAASAADMALSDAGIERSDIALTLLATSTPDHLLPPTAPLLTHWLNLQNSGAADLAGACTGFLYALVLADGFVRAQGKPVLVVAANLLSRRINMAERASAVLFGDAAGAVVLAPSAKANSFQSQFITNGSHYDLIKVPAGGSARAYAPERDASEFLMTMQDGRAVFTEAVRIMSGASQNVLASAAMLPQAIDRFFPHQANIRIVDKVCETIGVPRAKAASTLETYGNSSAATIPLSLSLANLEQPLREGERLLFAAAGAGMTGGAVLMQV
What is the function of this protein?
Involved in the formation of the biotin precursor pimeloyl-ACP (PubMed:33154364).  Catalyzes the condensation of glutaryl-CoA, an intermediate in lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP (PubMed:33154364).
What are the official names of this protein?
3-oxopimeloyl-[acyl-carrier-protein] synthase, 3-oxopimeloyl-[ACP] synthase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. BioZ family.