PharMolix/UniProtQA huggingface dataset:
Protein: RSMG_STAAM
Sequence: MTVEWLAEQLKEHNIELTETQKQQFQTYYRLLVEWNEKMNLTSITDEHDVYLKHFYDSIAPSFYFDFNQPISICDVGAGAGFPSIPLKIMFPQLKVTIVDSLNKRIQFLNHLASELQLQDVSFIHDRAETFGKGVYRESYDVVTARAVARLSVLSELCLPLIKKGGQFVALKSSKGEEELEEAKFAISVLGGNVTETHTFKLPEDAGERQMFIIDKKRQTPKKYPRKPGTPNKTPLLEK
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_STRPD
Sequence: MRVRKRKGAEEHLANNPHYVILNPEDAKGRWHDVFGNDRPIHIEVGSGKGGFITGMALKNPDINYIGIDIQLSVLSYALDKVLASEVPNVKLLRVDGSSLTNYFEDGEVDMMYLNFSDPWPKTKHEKRRLTYKDFLDTYKRILPEHGEIHFKTDNRGLFEYSLASFSQYGMTLRQIWLDLHASNYEGNVMTEYEEKFSNKGQVIYRVEANF
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: ARGR_SHELP
Sequence: MQANKNQDELVKTFKAILKEERFGSQSEIVNALQSEGFNNINQSKVSRMLSKFGAVRTRNAKQEMVYCLPAELGVPTAGSPLKNLVLDVDHNQSMIVVRTSPGAAQLIARLLDSIGKPEGILGTIAGDDTIFICPSNIQEVDKTLETVKSLFNYAD
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31B_XYLFT
Sequence: MKPEIHPIYREVVFHDVTSNFKFLTRSTMGTKETTLWEDGLEYPLVKVEISSASHPFYTGKHKLVDTSGRIDKFKKRYAR
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: PPNP_ALCBS
Sequence: MFKVNEYFDAKVASIAFQTETKPATIGVMAPGDYEFGTSEHETMTVTSGALTVKLPGSADWQTFVAGETFEIEADQKFQVKVAIDTAYLCLYGE
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: CITX_STRP6
Sequence: MSKEAYFSGESIQLSDMLRAREERALRQLHLLKEYPEGSLLSVTMNIPGPIKTSPKLLEAFDIVIKAIQTALADDKICYQLRLLPTTGYEYYLITSLPSRDLKLKMIALETELPIGRLMDLDVLVLQNDLPHSISRTVLGGSPRQCFICSKEAKVCGRLRKHSVEEMQTAISKLLHSFFNKDNQSSSSDKTG
What is the function of this protein?
Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein.
What are the official names of this protein?
Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, Apo-ACP nucleodityltransferase, Holo-ACP synthase, Holo-citrate lyase synthase.
What is the protein family that this protein belongs to?
Belongs to the CitX family.
Protein: HIS4_PARXL
Sequence: MLLIPAIDLKDGQCVRLKQGDMDQATIFSEEPAAMARHWVDRGARRLHLVDLNGAFAGKPKNEDAIRAIIAEVGGEIPVQLGGGIRDLNTIERYLDDGLSYVIIGTAAVKNPGFLQDACTAFGGHIIVGLDAKDGKVATDGWSKLTGHEVADLARKFEDYGCESIIYTDIGRDGMLQGINIEATVRLARAVKIPVIASGGLSNLADIESLCEVEDEGIEGVICGRAIYSGDLDFAAAQTLADRLRESDDA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRMA_CLOPE
Sequence: MEGTWIEVRVITKSEALEPISGIFYGLDCKGVAIEDPNDILGREQGPLTWDFADINILEHKGKVAVVKGYFSEEDNIDDVIAYVKERVEELKESGLDVGEGTVEAEKMFEEDWANNWKKYYKPIKIGEKIVIKPIWEEYEPTGEEMVVELDPGMAFGTGDHETTRMCVQALDKYVKADTTVFDIGTGSGILALVASKLGAKHVVGVDLDPVAVDSAKENISFNNVDNIEVLYGNLLDVVDGKADIVVANIIAEIICILVDDVKKALNKDGIFITSGIIHERRQMVIDKLEQEGFEVMEVNKDGEWNCIVAKLK
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_BRUSU
Sequence: MSDAFDINDLKRRMEGAVNALKHDLGGLRTGRASASLLEPITIEAYGSTMPINQVANISVPESRMLSVSVWDKSMVGAVERAIRDSGLGLNPITDGMTLRIPLPELNEQRRKELVKIAHQYAEQGRIAARHVRRDGMDQLKKLEKDSVISQDESRVLSEKVQKLTDDTIAEMDKIVAVKEGEIMQV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_MYCBP
Sequence: MPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNNRDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVLVHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEARELAEFVRDDIAQRGWPVFCVSTATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGARSGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LICA_BACIU
Sequence: XXKEIXWIFHDN
What is the function of this protein?
Has antibacterial activity against Gram-positive and Gram-negative bacteria including Salmonella, B. cereus, B. megaterium, L. casei, L. viridescens, M. flavus, C. glutamicum, C. crenatum, L. mesenteroides and E. faecalis.
What are the official names of this protein?
Subpeptin JM4-A.
What are the subcellular locations of this protein?
Secreted.
Protein: RL7_HYDS0
Sequence: MATLTIDEIVDAISGMTVLEVAELVKKLEEKFGVSAAAMVAASPAAGGAAASPAAEEKTEFDVILQDAGANKLNVIKVVRELTGLGLKEAKDLVDGAPKPIKQGVSKEEAENIKKKLEEAGAKVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: SYE_XANC5
Sequence: MTCRTRFAPSPTGYLHIGGARTALYCWLEARHRGGQFVLRIEDTDRERSTQAAIDAILEAMDWLGLGYDEGPIYQTQRIARYQEVAEQLLAQGKAYYAYETREELDAMREAAMAKQEKPRFNGAAREQNLPYRDDPNRVIRFKNPIGGTVVFEDLIKGCIEIANSELDDMVIFRPDGFPTYNFAVVVDDWDMGITEVIRGDDHINNTPRQINIYEALGAPVPRFAHMPMILDEQGAKLSKRTGAADVMQYKDAGYLPHALINYLARLGWSHGDQELFTRQELLDLFDVKDVNSKAARLDMAKLGWVNQHYLKTDDPASIAPQLEYQLAKLGVDIAAGPAAADVVVALRERVQTLKEMAEKAVVWYQPLETYDEAAVMKHLKLGAEVPLGKARELLAAVDAWSVENVSAALHDAAAALELGMGKIAQPLRVAITGTQVSPDISQTVYLAGREGALKRIDAALIKIGAA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF8_XENTR
Sequence: MFPTIRSCARGTSTPADNYMLARRRTLQVVVSSLLTEAGFESAEKAAVESLTEMLQSYLSEIGRSAKSYCEHTARTQPTLPDIVVTLIEMGFNVESLPAYAKRSQRMVITAPPVTNNPVVPKALSAGQNKQHPAHIPSHFPEFPDPHTYIKTPTYREPVCDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDTSTFPLIAARPLSIPYLNALLPSELELQQVEETDSSEQDDQTDAENLSMHLQGDEVGMEKENSSVLQQNSMKGGEETLIDNPYLRPVKKPKLRRKK
What is the function of this protein?
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.  TFIID recognizes and binds promoters with or without a TATA box via its subunit tbp, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC).  The TFIID complex consists of tbp and TBP-associated factors (TAFs).  Mediates both basal and activator-dependent transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 8, TBP-associated factor 8.
What is the protein family that this protein belongs to?
Belongs to the TAF8 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RL1_RALPJ
Sequence: MAKISKRAAANKAKVERTKFYPIDEALSLVKECASAKFDESIDVAVQLGIDAKKSDQVVRGSVVLPAGTGKSVRVAVFAQGDKAEQAKAAGAEIVGMEDLAEQIKAGKMDFDVVIASPDTMRVVGTLGQILGPRGLMPNPKVGTVTPDVATAVKNAKAGQVQFRVDKAGIIHATIGRRSFEPAALKSNLAALLDALTKAKPASSKGVYLRKVAVSSTMGVGVRVDQATLAA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: RIMB2_CHICK
Sequence: MREAAERRQQLELEHEQALAVLNAKQQEIELLQKAQVEAKKEHEGAVQLLEAKVRELEEKCRTQSEQFNLLSRELEKFRQQAGKIDLLSSNPLTSSDISGSPSKSLSQLMNGIATSLGKGHESPSGSRCVISEFIRPLQISGDKPEQLSVKPTFLSKSRSDTPRCRFDSDMDNDQNSNTSKQRYSGKVHLCIARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNETRLSSTLSSEQDQNFINHSGSTLEGDILEISPPSHIDSSVISNGAGTLDVNIDEIGEDIVPYPRKITLIKQLAKSVIVGWEPPVVPPGWGTINSYNVLVDKEVRMNIALGSRTKALIEKLNISTCTYRISIQSITNKGNSDELQCTLLVGKDVVVAPSNLKVDNITQISAELSWLPTNSNYSHVIFLNEEEFDIVKAASYKYHFFNLKPNMAYKVKVMAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVRAGSTQATIQVSWKPPALTATGTSHGANVTGYGVYAKGQRVAEVIFPTAENTLVELMRLRNLEAKEVTVRTLSAQGESVDSSVAAIPSDLLVPPSPHPRTAPKSKPLASAGAPETKEEHLGPHLKIDESWEQTHSASPVHGHTLEPPVPNFPSSLQGRRSPSPNRILPQPQGTPVPNTVAKAMAREAAQRVAESNRMERRSVFSERSNAAQYANSDDEEDGYDSPNVKRRGASVDDFLKGSELGKQPHYCHGEDYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRVSLTSHNALKECNKNKTTDATFLEQPDFSQQIHHSKKLFSIPEVAEEDGEYSELLYKQGLGMPYKKKSTIARDSRPPRPYNQDQQHNFWYPAKHRISGMEDFTADDKGCKYSRSLSRSPDSGLDCGSEEEESRFTFRYTCDSVSANVASSCCADTADCSCRKSMRPLLARRKTLTRQTSIEEDFGDLGSSFVEPRSEQVKSSYEKKYETQKCNRTDNLSNEDIQGGWKNDLKMADSRAAGPLAKSSHRDAEDSLLLGNPSSAGRPERVEHAGRRSSHGSAVPQRSRPMLVPSIDGYGGHDHLSPDIYEESETDPGTEDISTRIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCTRIGLIPCNMVSEIQADDEEMMDQLLKQGFLPLNTPVEKIERNRRSGRQHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDDVEVYLSDAPSRYLHDTPMRTKAKRKKSVHFTP
What is the function of this protein?
Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
What are the official names of this protein?
RIMS-binding protein 2, RIM-BP2.
What is the protein family that this protein belongs to?
Belongs to the RIMBP family.
What are the subcellular locations of this protein?
Cell membrane. Synapse. Note=Synaptic plasma membrane.
Protein: YR044_MIMIV
Sequence: MKYIKNNVLDLGSKDSYIKFNLSTVIDYIYNQIPLDYAEMNKIYKNICTELDDSPEFQSNLTEDDEYVYKFNEILKKCYDEQEMTKRKIFDPDFLNYKLINELHIYLTKKSPKKLVIKSINSIKLVNNEGVNTDINGTTNVDWKLHFWPEFTIQNSECLTLHDIIIACYKIKSHKFENWYELYCNMFTEFYVFQNSNDKNIWKEIFAVIKFDHGC
What are the official names of this protein?
Uncharacterized protein R44.
What is the protein family that this protein belongs to?
Belongs to the mimivirus L31/R44 family.
Protein: RL28_PELPB
Sequence: MSKVCLLTGKRPIYGNTVSHANNHVRTRFEPNLHTKRIWIEEEKRFVKVKLSAKAMTIIAKTGTATLAKLLK
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RS19_STRCO
Sequence: MPRSLKKGPFVDDHLIKKVDTQNEAGTKNVIKTWSRRSMIVPAMLGHTIAVHNGKTHIPVFVTESMVGHKLGEFSPTRTFRGHVKDDRKSKRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: PYRC_NEIG2
Sequence: MQTLTIIRPDDMHLHLRDGDALKAVAPYTARQMGRAVIMPNLKPPVVSVADALAYKARIMAALPEGSAFEPLMTLYLTDQATPELVREAKAAGIVAFKLYPAGATTNSDSGVTDLFKLIPVLEEMAKQGILFLVHGEVTDPEIDIFDREAAFIGRVMKPVLAQVPNLKVVFEHITTAEAARLVLEAGDNVAASVTPQHLLLNRNDLLVGGVRPHHFCLPVLKRETHRQALVAAVTGEKAHKFFLGTDSAPHAKSAKENACGCAGMFSAMTAIELYAEVFEKAGALDKLEAFASENGARFYGIPENADTITLVKQSQTVPASVPYGDGELVPMRAGGEIGWTVQY
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: MDCB_PSEF5
Sequence: MHAFNLQSPTPSLAERLADLAVDALIDEADLSPKPALVDRRGNGAHTDLHLGLMHASALSLWPAFKEMADAALLLGQVGLPLREALGRIGREGEQAMLATTGGVNTHRGAIWALGLLVAAAALEPQATSAGSVALRAARLALLEDRYAPRPLSHGAQVALRYGVRGAREEAQQGFPAVLQLGLPQLKRSRAQGHGEQNARLDALLAIMSRLADTCVLYRAGELGLQAMQQGARAVLDAGGSATLAGRRRLHELDLQLLTLNASPGGAADLLAASLLLDRIESGDAVNQGAN
What is the function of this protein?
Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: NU4LM_MONMO
Sequence: MSLVHINILMAFTMSLTGLLMYRSHLMSALLCLEGMVLSLFILATLTILNSHFTLANMMPIILLVFAACEAAIGLALLIMISNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YCF15_CALFG
Sequence: MLLLKHGRIEILDQNTMYGWYELPKQEFLNGEQPEPITHYIKQFPLMKHVNPLENQKDACPMKWLLLSAPITNHWFN
What are the official names of this protein?
Putative uncharacterized protein ycf15.
What is the protein family that this protein belongs to?
Belongs to the ycf15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SSRP_NOCFA
Sequence: MTVMKEKGRKVIATNRRARHNYTILDTYEAGIVLVGTEVKSLREGKASLVDAFATVDNGEVWLRGLHIPEFSHGTWTNHSPRRVRKLLLHKREIERLVGKSREGNQTLVPLSMYFSDGKVKVELALARGKQDYDKRQDLARRTAEREVTRELGRRVKGMR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: GLYA_OENOB
Sequence: MTKNFLDPQLAKAVSGEEERQRHNIELVASENFVSKAVRQAQGSVLTNKYSEGYPGKRYYGGNEYIDIAENLAIERAKELFGVSYANVQPHSGSSANFEAYMAFLHPGDKILGMNLDSGGHLTHGASVSFSGKMYEAQSYKVDSETELLDYDAILKQAKEFKPNLIIAGASAYSRTIDFQAFRDIADEVNAYLMVDIAHIAGLIAAGLHPSPVGLADIITTTTHKTLRGPCGGMILADEKYAKRINSAVFPGSQGGPLDHVVAAKAAAFYEDLQPDFKTYSAQIIKNAKTMADAFSKEPDVRVVSGGTDNHMFTLDLTKTGLNGRQVQDLLDSVSITLNREALPNEKRSPFVTSGVRIGTPAMTTKGLKENEMLQIEHLIMRAIHAHDDKNELTKIKRDVFDLMDKFPFDSNPF
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAI3_HUMAN
Sequence: MAPKQKKKTSRGKKRLKPVLAASEDMEPVNMESMGHPEIYPLVLTTKTQEIFNCRIDEDVTDEQPYKLINKEDIFEDLRNRAAVSDFHPVKKIVQEYPGNELLLVYDKDFKYGLNFYLIATEEGKENYLNPPEVPEEQEEYKEHIPEDVYIYKPPVSKPWVSLGSEKEIEEESVTESTKQITYMISRKRSEFGAPIKFSDQNASSVKDAYIECTAYPDKNFTLKQLEKDVGMQVIPQIKDISTQTKWTYPKNATTQYYPREFSEEEKETLKQSKPLVDFLNNASISVEIALQQNEIMNTFIDDWKYLAEEEGTFGDKTDTHLKEYQSFTDLHSPTEKMITCVSWHPTIYGLIAVSVAVRLSFEDRVHFSGKLLLQPSLILFWSFSDPIHPQLMLESPDDIFCFKFCPSDPNIIAGGCINGQIVMWDITAHADRIENIKAGGSRSKRATLKPMFLLEPESNKEAMYIRHCAVSSIENGHKKVITDIHWLSDTFEINRMGSVFENRSGICCQLVTCSADCTICFWDIRPQKPLTPQTTEKKKEESIEIPFDVPSTFLHLDLSWKPLTKVRLSKGETSLDHCPTKISLNEDHLLCKTQDKMLAQSKTEKAEEMNPYHNLESGMANLLKPIDDFCTKFFVGTEEGEVIYTDWKMEKDPETGRLMSKKPVSHHTIHDGTVHTIQRSPFYNDIILTVGGWNVAIWKEGVMTGPLLQSCCAPKRYTSGHWSLTRPGVFYIGREDGYIDIWDLLEKTHEPAQSQNICITMITYIKPWIFSSKQQFIATADYYGTLHILEIPWTLSRPSTNEMASVNHYFEREVKHLEYVEQRKKIREQEKKEMELEMAKKKVKTYQKSKEQMQAELKMDYESYLELEKTVLINLGLIKVTEKGSYMEVM
What is the function of this protein?
Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization (PubMed:32128961).  Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function (By similarity).  May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells (By similarity).
What are the official names of this protein?
Dynein axonemal intermediate chain 3, Testis development protein NYD-SP29, WD repeat-containing protein 63.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_MOOTA
Sequence: MPLVRVPATTANLGPGFDTLGMALNLFDELKIEESSSPEIIITGEGEGTIPRGQENIAYRAARAVFAKVGRPPVPLKLEMHNSIPVARGLGSSAAALVGAIVGTNAILGGPLGPAELVNLATTLEGHPDNVAPAILGGLVASARDGEQVICRRLELPPGLVTVVAIPQFTLSTRISRGVLPAKVDLEDAVFNISRVAVLLAAVATGDLDLMGRMMVDKLHQPYRLPLIPGMAEVFAAAREAGALAVTLSGSGPTVIAFCRGRQPKVGPAMAAAFARKGVKCTVKELAPCNHGAVVI
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSC_SHESA
Sequence: MSNIVWHQHSVDQAARAKLKGQNPVLLWFTGLSGAGKSTLAGALERALFEAGFHTYLLDGDNVRHGLCKDLGFSVADRDENLRRVGEVAKLMVDAGLVVLSAFISPTREERDSIRARFPEGQFIEVHVSTPLSICEQRDPKGLYVKARRGEISNFTGISSPYEAPLSAELTIDTSKGDLASQVRALIDYLTAIGVINPDKAKALA
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: MDM4_RAT
Sequence: MTSHSTSAQCSASDSACRISSEQINQQVRPKLQLLKILQAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHLVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVTSASVNTDAAQTLALAQDHTMDIPSQDRLKHGATECSNPRKRTEEDDTHTLPTSRRKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNYIPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGVKVEAANCEQPSEVGRTRDKKMVEGGKDDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSVEFLDLAHGSESQEIISSTREQTDIFSEQKTETESMEDFQNVLKPCSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA
What is the function of this protein?
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.  Inhibits degradation of MDM2.  Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity).
What are the official names of this protein?
Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4.
What is the protein family that this protein belongs to?
Belongs to the MDM2/MDM4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SBT35_ARATH
Sequence: MRNCRVLLVLVLSLVIVLNVVRASDESKVHIVYLGEKQHDDPEFVSESHHQMLSSLLGSKVDAHESMVYSYRHGFSGFAAKLTESQAKKLADSPEVVHVMADSFYELATTRTWDYLGLSVANPNNLLNDTNMGDQVIIGFIDTGVWPESESFNDNGVGPIPSHWKGGCESGEKFISTNCNRKLIGAKYFINGFLAENEGFNTTESRDYISARDFIGHGTHTASIAGGSFVPNISYKGLAGGNLRGGAPRARIAIYKACWYVDQLGAVACSSSDILKAMDESMHDGVDVLSLSLGAQIPLYPETDLRDRIATGAFHAVAKGIIVVCAGGNSGPAAQTVLNTAPWIITVAATTLDRSFPTPITLGNRKVILGQALYTGQELGFTSLVYPENAGFTNETFSGVCERLNLNPNRTMAGKVVLCFTTNTLFTAVSRAASYVKAAGGLGVIIARNPGYNLTPCRDDFPCVAIDYELGTDVLLYIRSTRSPVVKIQPSRTLVGQPVGTKVATFSSRGPNSISPAILKPDIGAPGVSILAATSPDSNSSVGGFDILAGTSMAAPVVAGVVALLKALHPNWSPAAFRSAIVTTAWRTDPFGEQIFAEGSSRKVADPFDYGGGIVNPEKAADPGLIYDMGPRDYILYLCSAGYNDSSITQLVGNVTVCSTPKTSVLDVNLPSITIPDLKDEVTLTRTVTNVGTVDSVYKVVVEPPLGIQVVVAPETLVFNSKTKNVSFTVRVSTTHKINTGFYFGNLIWTDSMHNVTIPVSVRTQILQNYYDEN
What is the function of this protein?
Serine protease that cleaves the pectin methylesterase 17 (PME17) protein to release the PME17 mature form in the apoplasm.
What are the official names of this protein?
Subtilisin-like protease SBT3.5, Subtilase subfamily 3 member 5, AtSBT3.5.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Identified in cell-wall-enriched root protein extracts.