PharMolix/UniProtQA huggingface dataset:
Protein: RUVA_ANADE
Sequence: MIARLAGRIAEKRDDHAIVDVGGVGYLVHVSQLSLASLPPPGEPAALRVYTHVREDALDLYGFATEDEEAVFRALIDVKGVGPRAAQNILSGIEARELAQAVAQGDVARLTKVQGIGKKTAERLVVELKDKLVALARAAGPARAGAEADVLDQLRTALLNLGYRPPQAEGVAEALRDSAEGRPLDELLREALKRLRG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RS21_BUCAI
Sequence: MPIIKVRENEPFDVALRRFKRSCEKAGILAEIRRREFYEKPTTERKRAKASAVKRLAKKLTRENARRIRMY
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: EFP_SHEFN
Sequence: MKTAHEIRPGNVIMLDGSPWVVQKTETTRSGRNAAIVKLKLKNVLLDSGTEQTFKGEDKLDDIILERLDCTYSYFADPMYVFMDEEYNQYDVEADNLGDAADYIIDGMEDVCQVTFYEGKAISVELPVHIVREVIYTEPSARGDTSGKVMKPATITGGGTVTVADFVKVGDKIEIDTRTGEFKKRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_SYMTH
Sequence: MDQQALDKAAVLAEALPYIREFSGKTVVIKYGGAAMAAADLKAAVMQDIALMKYVGMHPIVVHGGGPEVSELARRMGIEPQFVDGLRVTDAATMEIAQMVLVGKTNREIVTHLCAQGVKAVGLSGQDAGLIRAARHLHRSRETGEMVDLGFVGDVAAVDTEVLTTLTTAGYVPVIAPIGVGPGGQPYNINADTVAGAIAAAMKAEKLVLLTDVEGVRADKDDPSSLLSRVTAQEVKSWIARGRLQGGMIPKLQCCLTALEGGVNRVHIIDGRVPHSLLLEIFTDEGVGTMVVK
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIX1B_DANRE
Sequence: MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENNNTGANKQNQLSPLDGGKSLMSSSEDEFSPPQSPDQNSVLLLQGNMSHPGASAYSMTGLGAAQSVHGMQGHPHQLQDSLLGPLTSSLVDLGS
What is the function of this protein?
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development.  Depending on context, functions as transcriptional repressor or activator.  Transcriptional activation is enhanced by eya1 (in vitro).  Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells.  Required for normal myogenesis.  Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles.  Required for normal expression of myod1 and myog during myogenesis.
What are the official names of this protein?
Homeobox protein six1b, Homeobox protein six1a, Sine oculis homeobox homolog 1a, Sine oculis homeobox homolog 1b.
What is the protein family that this protein belongs to?
Belongs to the SIX/Sine oculis homeobox family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: UVRB_WOLTR
Sequence: MKFQLVTHFQPAGDQPQAIDSLVAGLNDNKRDQVLLGVTGSGKTFTMANVIARTNRPALIIAHNKTLAAQLYEEMKGFFPHNAVEYFISYYDYYQPEAYLPQTDTYIEKDSVINERIDMLRYSAVCSLLERRDTIVVASVSCIYGLGSPESYLSMTITLSTGDRIRINDFLNDLANLQYKRSDIRFERGYFRMRGDVIDIFPAYYEDKAWRLLLIGNEIEGISEINAITGNIIKCIDKITIFPNSYHITSRETLLRAVQPIREELNERLDYYYSQNKIVEAQRLEQRTNFDIEMMVATGTCKGIENYSRYLYGMEAGDAPPTLFEYLPEDVILFVDESHVTVPQIGAMYNGNESRKKKLIDHGFRLPSAFDNRPLKFKEWESMRPQTIYISATPGKYELARTNNLFVEQVIRPTGITDPICIVKPAEAQVYDVVHEAQVTIKRGFCVLITTLTKKMAEKLAEHMSELNMKVSYLHSDISALERIDIVYKLRSKEIDVLIGVNLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRAARNAESRAILYADKVTGSMDRALKETERRRKKQKKYSVLHNVLPKTIIKPISNTLKEKVVVKVTTIGMNKDTVSSLRKQMLAHAKNLEFEEAAKIKNIIGRINNL
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHD_CHICK
Sequence: MAVLLALFGALVLSGGLCVNQEERLIHHLFEERGYNKEVRPVASADEVVDVYLALTLSNLISLKEVDETLTTNVWVEQSWTDYRLQWNTSEFGGVDVLRLLPEMLWLPEIVLENNNDGLFEVAYYCNVLVYNTGYVYWLPPAIFRSACPINVNFFPFDWQNCTLKFSSLAYNAQEINMHLKEESDPETEKNYRVEWIIIDPEGFTENGEWEIIHRPARKNIHPSYPTESSEHQDITFYLIIKRKPLFYVINIVTPCVLIAFMAILVFYLPADSGEKMTLVISVLLAQSVFLLLVSQRLPATSHAIPLIGKYLLFIMLLVTAVVVICVVVLNFHFRTPSTHVMSDWVRGVFLEILPRLLHMSHPAESPAGAPCIRRCSSAGYIAKAEEYYSVKSRSELMFEKQSERHGLASRVTPARFAPAATSEEQLYDHLKPTLDEANFIVKHMREKNSYNEEKDNWNRVARTLDRLCLFLITPMLVVGTLWIFLMGIYNHPPPLPFSGDPFDYREENKRYI
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RBM8A_DROME
Sequence: MADVLDIDNAEEFEVDEDGDQGIVRLKEKAKHRKGRGFGSDSNTREAIHSYERVRNEDDDELEPGPQRSVEGWILFVTSIHEEAQEDEIQEKFCDYGEIKNIHLNLDRRTGFSKGYALVEYETHKQALAAKEALNGAEIMGQTIQVDWCFVKGPKRVKKSEKRRR
What is the function of this protein?
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:24967911).  Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983).  The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm (PubMed:24967911).  Has a role in oskar mRNA localization to the posterior pole of the developing oocyte (PubMed:11691839).
What are the official names of this protein?
RNA-binding protein 8A, Protein tsunagi.
What is the protein family that this protein belongs to?
Belongs to the RBM8A family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Part of the EJC assembled on mRNAs in the nucleus and remains part of the complex when mRNA moves into the cytoplasm.
Protein: ATPL_STRP7
Sequence: MNLTFLGLCIACMGVSVGEGLLMNGLFKSVARQPDMLSEFRSLMFLGVAFIEGTFFVTLVFSFIIK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: F228B_BOVIN
Sequence: MKSYENDPITDKLPKLKSSREWLEPQPLSFMEVLAKEDVDTAIQSILYRENYIIKELDKCLKHHDFLNARRKEILYKRWVDHVADPLQKKIIEKVTSYKKIKKRRQEELDGFLKYVNKKGNAFIEHYDPKEYDPFYMNRENPNFLKVTIPPFRDPLKKAQYDKDDGKRILLQCETGKIYTMKEFKEVEKAKLHSRFPGISNSRHLMTPNEWIRLPPNYIESEFCKRSRLKIKVNFNESSFDLKPSVRTPHPEFQKEDKAVHYKF
What are the official names of this protein?
Protein FAM228B.
What is the protein family that this protein belongs to?
Belongs to the FAM228 family.
Protein: HOKC_ECOLI
Sequence: MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE
What is the function of this protein?
Toxic component of a type I toxin-antitoxin (TA) system.  When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respiration (PubMed:10361310).  Its toxic effect is probably neutralized by antisense antitoxin RNA SokC (PubMed:10361310).
What are the official names of this protein?
Toxic protein HokC, Protein Gef.
What is the protein family that this protein belongs to?
Belongs to the Hok/Gef family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: GPMA_DESVV
Sequence: MARLILLRHGQSAWNLENRFTGWTDVDLSPAGEAEALAAARLIRDEGLDFSVCHTSMLTRAIRTLHLVQHELDRLWTPVRKHWRLNERHYGALQGLDKRETAARHGEDQVFVWRRSYDVPPPVIAPDDPKHPVHDPRYADVPPDVLPCGESLEATVARVLPYWYDAIAPDLMAGRDVLVAAHGNSLRALVMHLDGLDREAVSRLDIPTGLPRLYELDAALRPVSYRYLGDPAEAEERARAVAAQGRLEKN
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: ECHM_MOUSE
Sequence: MAALRALLPRACSSLLSSVRCPELRRFASGANFQYIITEKKGKNSSVGLIQLNRPKALNALCNGLIEELNQALETFEQDPAVGAIVLTGGDKAFAAGADIKEMQNRTFQDCYSSKFLSHWDHITRVKKPVIAAVNGYALGGGCELAMMCDIIYAGEKAQFGQPEILLGTIPGAGGTQRLTRAVGKSLAMEMVLTGDRISAQDAKQAGLVSKIFPVEKLVEEAIQCAEKIASNSKIVVAMAKESVNAAFEMTLTEGNKLEKRLFYSTFATDDRREGMTAFVEKRKANFKDH
What is the function of this protein?
Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding (3S)-3-hydroxyacyl-CoA species through addition of a water molecule to the double bond.  Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (By similarity).  Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA).  Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (By similarity).  Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation.  At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity).
What are the official names of this protein?
Enoyl-CoA hydratase, mitochondrial, mECH, mECH1, Enoyl-CoA hydratase 1, ECHS1, Short-chain enoyl-CoA hydratase, SCEH.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: VP1_POVMA
Sequence: MAPKRKSGVSKCETKCTKACPRPAPVPKLLIKGGMEVLDLVTGPDSVTEIEAFLNPRMGQPPTPESLTEGGQYYGWSRGINLATSDTWIPRNNTLPTWSMAKSSFPCLNEDLTCDTLQMWEAVSVKTEVVGSGSLLDVHGFNKTHRFSKHKGNSTPVEGSQYHVFAGGGEPLDLQGLVTDARTKYKEEGVVTIKTITKKDMVNKDQVLNPISKAKLDKDGMYPVEIWHPDPAKNENTRYFGNYTGGTTAPPVLQFTNTLTTVLLDENGVGPLCKGEGLYLSCVDIMGWRVTRNYVSSLEKGFPRYFKITLRKRWVKNPYPMASLISSLFNNMLPQVQGQPMEGENTQVEEVRVYDGTEPVPGDPDMTRYVDRFGKTKTVFPGN
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins.  Interacts with terminal alpha(2,3)-linked sialic acids on the cell surface to provide virion attachment to target cell.  Once attached, the virion is internalized by caveolin-mediated endocytosis and traffics to the endoplasmic reticulum.  Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating.  Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal.  In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.
What are the official names of this protein?
Major capsid protein VP1, Major structural protein VP1.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses coat protein VP1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: CF157_CHLRE
Sequence: MWAVARLGLRLRASWWEAQAGRLMPGGGGGSAAAAAMQEEQGEQEGPTGRDLSNALYALGEGVVANTLWALQQLLAPARAEQEHPQEGRPQQQEQGGEARQEQQGQQAPRQLWWALLERSRQHMEATCVQQQGQGRGQAADGKSTSSRGAAGGGVAKAVARGPRGAGTARGPLGTAAAPLRRVLWGAGRQDVCVYLSGLRRLHMPPPPSLAVPLMQRLEQQLLAAEGEAQAEAAVPARAPPSTASTAAPPSARCLVYLAVELSHMGPLGPLGPLGPLGKAQAGGQQVPVQVQVPGVEADVGSLGARECADLCVALVRLGVSLPRGAGSGKATMPHPHPSPHLRYDEQPQLSGADLGPSADMAPLPLDTGERALPEPSSHPPVARQQLGEQPGEQPGGPHEDEEDWDPAFVADGYEAEAGELPKRPSASGGGMEGSFSLPQQLALAQSLHWLDQAAAHMMQTGAEDAASVDEEAEAPEADAVLAAALAAARDDTALYLFCSWAPSSLSSLSSLSATATATAAALRLRLTGAAHVVEGAALQAAAAALDAACWKQQGAGPGVVVGKDREVQAAAPAGPPGDLEAEQVVCAPCMCTGSIDTPDQPPAPNNLNNPHPSAFHRYQDHGDRLQVDVVRLTDELETQKLNLRDINEFLTNELKSKVAELNGLMDEVKKSHEASLARLRGDKDRELERLEGVVREHERKARITQEFLDKKEALEAEMQSLKETLARKTKDFEQQLTDIDRQHIQDREKWKREMAGRIKETKLQMMKLTDNQLEMTTKRTIMENEQMSIELSYQSRQTEKLLNKNNKLMEENAELRRQLELSKQTEEELARRNNLYQKTIKTLLSKLQDQGYQAAESEEVLGALDGRLGDLAAHLHLAQLQLEEKSAEADALRERLESKTAEAAALTSGYDDTARFLLACMADVRDKVVTVVRTTTTNNTSSDERLPPLAGADAAGGSRSGSPTPPGASSSAAGGGDITVLPGRLDELSPEQRERVLGWLLERLHYATGLSHGPLSQSSPAPLSAGGMGSALAGEWGPGSPGGSRLGRLPTREQDGSAGGMGGPQGLGATSGAAAAAAGAGGGLDGVSSLGGLGYGLGYGGVGVSSSVMAGMSPGPGVPGYSVSTGDVMPGGGMLGGAGVIGGGTGGGAGGAVVDEALAKVLSEVRPWGKRSEQQPLTTTKHSGTFLRKGNGPSNNTGSRGSLKV
What are the official names of this protein?
Cilia- and flagella-associated protein 157, Flagellar-associated protein 77.
What is the protein family that this protein belongs to?
Belongs to the CFAP157 family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum.
Protein: KDPA_DELAS
Sequence: MWLTWMEYALVLLLMTALAVPMGQWLARCFTSEHHAWIERLSFRALGVNPAERMGWQRYGLALLLSNGAMLLLGYALLRAQGWLPLNALGNAAQTPDLAFNTAASFVTNTNWQAYSGESSLSNATQMVAITFMMFAGAITGVVAAAGFIRGLARSSASDLGNYWVDYVRVLWRVMLPLSFVVALVYVWQGVPQALDGQVWATTLEGARQQILLGPVASLESIKHIGTNGGGFFGMNAAHPFENPTPLTNAIHILGMLLIPSAMTYAFGSMLLRRRQGWVLFGACLVMFVGFLALVFTAEQAGNPLLTAAGADQQISATQPGGNMEGKELRFGIADTALFVATTTAATTGSVNAMHDSLTPLGGLVPLAQMMINCVFGGDGVGLINLLQYAILTVFLAGMMIGRTPEFLGKKIEAREIKLVMLAVMAHPISVLGFTALAAVWPDTLASLANRGPHGFSEVLYAYASGTANNGSAFAGLNANTPFFNTTIGLAMLAGRYLTLLPMLALAGSLAAKPTVPAGPGTFPTATPLFMGLLVFVVVVVGGLTFLPSLALGPVVEQLQMLSGQVYP
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CSHA_STAAM
Sequence: MQNFKELGISDNTVQSLESMGFKEPTPIQKDSIPYALQGIDILGQAQTGTGKTGAFGIPLIEKVVGKQGVQSLILAPTRELAMQVAEQLREFSRGQGVQVVTVFGGMPIERQIKALKKGPQIVVGTPGRVIDHLNRRTLKTDGIHTLILDEADEMMNMGFIDDMRFIMDKIPAVQRQTMLFSATMPKAIQALVQQFMKSPKIIKTMNNEMSDPQIEEFYTIVKELEKFDTFTNFLDVHQPELAIVFGRTKRRVDELTSALISKGYKAEGLHGDITQAKRLEVLKKFKNDQINILVATDVAARGLDISGVSHVYNFDIPQDTESYTHRIGRTGRAGKEGIAVTFVNPIEMDYIRQIEDANGRKMSALRPPHRKEVLQAREDDIKEKVENWMSKESESRLKRISTELLNEYNDVDLVAALLQELVEANDEVEVQLTFEKPLSRKGRNGKPSGSRNRNSKRGNPKFDSKSKRSKGYSSKKKSTKKFDRKEKSSGGSRPMKGRTFADHQK
What is the function of this protein?
DEAD-box RNA helicase possibly involved in RNA degradation.  Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase CshA.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. CshA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS212_RHIEC
Sequence: MQVLVRDNNVDQALRALKKKMQREGIFREMKMRDYYEKPSQKRAREKAEAVRRVRKLARKRAQREGLVAR
What are the official names of this protein?
30S ribosomal protein S21 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: M34_CONPL
Sequence: LGVLLPICLLLFPLTALPLDGDQPADRPAERMQDDFITEQHPLFDPVKRCCDWPCNAGCVPCCF
What are the official names of this protein?
Conotoxin Pu3.4.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SMT3_YEAST
Sequence: MSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGATY
What is the function of this protein?
Not known; suppressor of MIF2 mutations.
What are the official names of this protein?
Ubiquitin-like protein SMT3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
Protein: CAPSD_FCVF9
Sequence: MCSTCANVLKYYDWDPHFKLVINPNNFLSVGFCSNPLMCCYPELLPEFGTVWDCDRSPLEIYLESILGDDEWASTFDAVDPVVPPMHWGAAGKIFQPHPGVLMHHLIGKVAAGWDPDLPLIRLEADDGSITAPEQGTMVGGVIAEPSAQMSTAADMATGKSVDSEWEAFFSFHTSVNWSTSETQGKILFKQSLGPLLNPYLEHLAKLYVAWSGSIEVRFSISGSGVFGGKLAAIVVPPGVDPVQSTSMLQYPHVLFDARQVEPVIFCLPDLRSTLYHLMSDTDTTSLVIMVYNDLINPYANDANSSGCIVTVETKPGPDFKFHLLKPPGSMLTHGSIPSDLIPKTSSLWIGNRYWSDITDFVIRPFVFQANRHFDFNQETAGWSTPRFRPISVTITEQNGAKLGIGVATDYIVPGIPDGWPDTTIPGELIPAGDYAITNGTGNDITTATGYDTADIIKNNTNFRGMYICGSLQRAWGDKKISNTAFITTATLDGDNNNKINPCNTIDQSKIVVFQDNHVGKKAQTSDDTLALLGYTGIGEQAIGSDRDRVVRISTLPETGARGGNHPIFYKNSIKLGYVIRSIDVFNSQILHTSRQLSLNHYLLPPDSFAVYRIIDSNGSWFDIGIDSDGFSFVGVSGFGKLEFPLSASYMGIQLAKIRLASNIRSPMTKL
What is the function of this protein?
Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins.  A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry.  The capsid encapsulate the genomic RNA and VP2 proteins.  Attaches virion to target cells by binding to feline junctional adhesion molecule A (F11R) and/or to alpha-2,6-linked sialic acid.  Once attached, the virion is endocytosed.  Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.
What are the official names of this protein?
Capsid protein, Coat protein, CP, VP1.
What is the protein family that this protein belongs to?
Belongs to the caliciviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: ATPA_TOBAC
Sequence: MVTIRADEISNIIRERIEQYNREVKIVNTGTVLQVGDGIARIHGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLLIQEGSSVKATGRIAQIPVSEAYLGRVINALAKPIDGRGEISASEFRLIESAAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVTTLQERGAMEYTIVVAETADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYLGDVFYLHSRLLERAAKLSSSLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNSGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFASDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIMTIYTGTNGYLDSLEVGQVRKFLVELRTYLKTNKPQFQEIISSTKTFTEEAEALLKEAIQEQMDRFILQEQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ACTS2_ALTAL
Sequence: MLTRRALVVQSQGEVQVEEIPLPTLRDEYITVKVKAVALNPGDWKMLYGPHATPGSILGCDYSGVVEKVGRAVNALLTPGDRVAGFAFGGCPYNHDEGGFASYVTAKGDIQAKLSDSISFEDAATLGVGITTVGQAMYQALGLPLPPAIIQEAASILVYGASTATGTLAVQYAKLTGLKVFATASPHNFDLLKKLGADEVFDYRDPECGAKIRTVTNGLLSLVFDTISEGSSPAIWAAAMGAKGGKYTALLPIKNFPRSDVKVTTILGYTALGVKVSDHLPANQKDFEFSAKFWKLSQHLLEKEKIKTHPVGVRQGGIDAIPQGLQDLKNGRVSGVKLVYKID
What is the function of this protein?
Trans-enoyl reductase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) ACT-toxins responsible for brown spot of tangerine disease by the tangerine pathotype which affects tangerines and mandarins (PubMed:19271978).  ACT-toxins consist of three moieties, 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA), valine and a polyketide (PubMed:22846083).  ACT-toxin I is toxic to both citrus and pear; toxin II the 5''-deoxy derivative of ACT-toxin I, is highly toxic to pear and slightly toxic to citrus (PubMed:22846083).  On cellular level, ACT-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The acyl-CoA ligase ACTT1, the hydrolase ACTT2, the enoyl-CoA hydratases ACTT3 and ACTT6, and the acyl-CoA synthetase ACTT5 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety (PubMed:18944496, PubMed:18986255, PubMed:19271978).  The exact role of each enzyme, and of additional enzymes identified within the AF-toxin clusters have still to be determined (PubMed:18944496, PubMed:18986255, PubMed:19271978).  On the other hand, ACTTS1 to ACTTS4 are specific to the tangerine pathotype (PubMed:22846083).  The function of ACTTS3 is to elongate the polyketide chain portion of ACT-toxin that is unique to this toxin (PubMed:20192828).  The enoyl-reductase ACTTS2 might complement the missing enoyl-reductase (ER) domain in ACTTS3 in the synthesis of the polyketide portion of ACT-toxin (PubMed:20055645).  The roles of the nonribosomal peptide synthetases-related proteins ACTTS1 and ACTTS4 have also still not been elucidated (PubMed:22846083).
What are the official names of this protein?
Trans-enoyl reductase ACTTS2, ACT-toxin biosynthesis protein S2.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.