PharMolix/UniProtQA huggingface dataset:
Protein: APH1A_MOUSE
Sequence: MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLSCRRQEDSRVMVYSALRIPPED
What is the function of this protein?
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:15634781, PubMed:19369254).  Required for normal gamma-secretase assembly (PubMed:15634781, PubMed:19369254).  The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).
What are the official names of this protein?
Gamma-secretase subunit APH-1A, APH-1a, Aph-1alpha.
What is the protein family that this protein belongs to?
Belongs to the APH-1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Protein: RL6_PSEP1
Sequence: MSRVAKNPVKLPSGVEVKFAGQQLSVKGAKGTLELNVHSSVEVTEESGELRFVARNGDQQARAMAGTTRALVNNMVQGVSQGFERKLQLVGVGYKAQAKGTVLNLALGFSHPVDYELPAGITAETPSQTDILIKGIDKQLVGQVAAEIRDFRPPEPYKGKGVRYADEVVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: NIKR_PYRFU
Sequence: MGIVRFGVSIPKELLEKFDGIIEEMGYTNRSEAIRDLIRDMVVRHEWQLGDEEVAGTITIVYNHDEADVVRELLDLQHEYLNEIVSSLHVHMDEHNCLEVIVVKGRAKKIKKIADRLLSLKGVKHGKLVMTTTGRDIV
What is the function of this protein?
Transcriptional regulator.
What are the official names of this protein?
Putative nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: CALR_BOMMO
Sequence: MKAVVLVVVSLLALSSINCDVFFEEKFPDDSWESNWVYSEHPGKEFGKFKLTAGKFFSDPEDDKGLKTSEDARFYALSRKFKPFSNEGKPLVVQFTVKHEQDIDCGGGYLKVFDCKLEQKDMHGETPYEIMFGPDICGPGTKKVHVIFSYKGKNHLIKKDIRCKDDVYTHLYTLIVKPDNTYEVLIDNEKVESGDLEADWDFLPNKKIKDPEAKKPEDWDDKPTIPDPEDKKPEDWDKPEHIPDPDATKPEDWDDEMDGEWEPPMIDNPDYKGVWAPKQIDNPAYKGPWVHPEIDNPEYTPDSNLYKRDEICAVGLDLWQVKSGTIFDDFLITDDPAAAKERGEVIKKRQEGEKKMKSEQDEAEREKEKAEKPDDEEDDEDLDDETGDAAPVEEHDEL
What is the function of this protein?
Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle.  This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).
What are the official names of this protein?
Calreticulin.
What is the protein family that this protein belongs to?
Belongs to the calreticulin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: TDH_XANC8
Sequence: MKALVKREASKGIWLEQVPVPTPGPNEVLIKLEKTAICGTDLHIYLWDEWSQRTITPGLTIGHEFVGRVAELGSAVTGYQVGQRVSAEGHIVCGHCRNCRGGRPHLCPNTVGIGVNVNGAFAEYMVMPASNLWPIPDQIPSELAAFFDPYGNAAHCALEFDVIGEDVLITGAGPIGIIAAGICKHIGARNVVVTDVNDFRLKLAADLGATRVVNVSKTSLKDVMADLHMEGFDVGLEMSGNPRAFNDMLDCMYHGGKIAMLGIMPRGAGCDWDKIIFKGLTVQGIYGRKMYETWYKMTQLVLSGFPLQKVLTHQLSIDEFQKGFDLMEEGKAGKVVLSWN
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNA2_CHLRE
Sequence: MAFALRGVTAKASGRTAGARSSGRTLTVRVQAYGMAAEYIWADGNEGKPEKGMIFNEMRSKTKCFEAPLGLDASEYPDWSFDGSSTGQAEGNNSDCILRPVRVVTDPIRGAPHVLVMCEVFAPDGKPHSTNTRAKLREIIDDKVTAEDCWYGFEQEYTMLAKTSGHIYGWPAGGFPAPQGPFYCGVGAESAFGRPLAEAHMEACMKAGLVISGINAEVMPGQWEYQIGPVGPLALGDEVMLSRWLLHRLGEDFGIVSTFNPKPVRTGDWNGTGAHTNFSTKGMRVPGGMKVIEEAVEKLSKTHIEHITQYGIGNEARLTGKHETCDINTFKHGVADRGSSIRIPLPVMLKGYGYLEDRRPAANVDPYTVARLLIKTVLKG
What are the official names of this protein?
Glutamine synthetase, chloroplastic, GS2, Glutamate--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EX7S_STRT1
Sequence: MSTKKTFEENLQDLEAIVTKLETGDVALEDAIAEFQKGMVLSKDLQKTLEDAEKTLVKVMQADGTEMEMDA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PXPA_STAA9
Sequence: MRVDLNCDLGEAFGNYSFGGDHQIIPLITSANVACGFHAGDENVMNETVKLAKAHNVAVGAHPGLPDLKGFGRRNIDISNDEIYNLMIYQLGALQGFCRIHQLKINHVKPHGALYQMGAKDREIANVIAQAVYDFDPSLVLVGLANSYLISEAKNVGLITASEVFADRRYEDDGQLVSRKESDAVITDTDEALKQVLKMVKENKVISKNNKEVTLQADTICVHGDGEHALLFVSKIREILMKEGIDIQSL
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: RL32_LIMRD
Sequence: MAVPARKTSKTKKRMRRGHIKLNVPGLTPCPNCGELRKSHMVCPSCGYYDGKQVVNTNN
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: TRIP6_BOVIN
Sequence: MSGPTWLPPKQPEPARAPQGRALPRGASGPPLAHGAALQPHPRVNFCPLPSEQCYQTPGEPEDRGLAWVGCHGAPQHSQGLPPDRGGLRPGSLDAEIDSLTSMLAELDGGRGHAPRRPDRQAYEPPEPPAYRSGSGPLRPNGGALPPPPLPGSPYGAPTPASYATASTPAGPAFPVQVKVARPVRGCGPPRRGASQASGPSPGPHFPLPGRGEVWGAGYRSHREPGPGVKEEAPGVSGPAGARGGGYGPQVPLSQPPEEELERLTKKLVHDMNHPPSGEYFGRCGGCGEDVVGDGAGVVALDRVFHVGCFVCSTCRAQLRGQHFYAVERRAYCESCYVATLEKCSTCSQPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKTCSAWRIQELSATVTTDC
What is the function of this protein?
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness.  Involved in lysophosphatidic acid-induced cell adhesion and migration.  Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity).
What are the official names of this protein?
Thyroid receptor-interacting protein 6, TR-interacting protein 6, TRIP-6.
What is the protein family that this protein belongs to?
Belongs to the zyxin/ajuba family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. Colocalizes with actin.
Protein: NUOCD_SALPB
Sequence: MVNNMTDLTAQDAAWSTRDHLDDPVIGELRNRFGPDAFTVQATRTGIPVVWVKREQLLEVGDFLKKLPKPYVMLFDLHGMDERLRTHRDGLPAADFSVFYHLISIERNRDIMLKVALSENDLRVPTFTKLFPNANWYERETWEMFGIDIEGHPHLTRIMMPQTWEGHPLRKDYPARATEFDPFELTKAKQDLEMEALTFKPEDWGMKRGTDNEDFMFLNLGPNHPSAHGAFRIILQLDGEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLREFLEWMPKRLDSYEKAALRNTILKGRSQGVAAYGAKEALEWGTTGAGLRATGIDFDVRKWRPYSGYENFDFEVPVGGGVSDCYTRVMLKVEELRQSLRILQQCLDNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPAQESFQMVEATKGINSYYLTSDGSTMSYRTRVRTPSFAHLQQIPSAIRGSLVSDLIVYLGSIDFVMSDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DTD_BREBN
Sequence: MRVVVQRTREASVTVAGEVVGQIDHGLMLLVGITHEDTEKEVEFVADKIANLRIFEDEEGKMNFSVLDKGGQILSVSQFTLYGDCRKGRRPNFMAAARPEQAEPLYELFNTKLREKGLQVETGRFGAMMDVRLLNDGPVTLIVES
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACBD7_BOVIN
Sequence: MSLQADFDKAAKDVRKLKTRPDDEELKELYGLYKQSVIGDIDIECPALLDLKGKAKWEAWNLQKGLSKEDAMNAYISKAKELIEKYGI
What is the function of this protein?
Binds medium- and long-chain acyl-CoA esters.
What are the official names of this protein?
Acyl-CoA-binding domain-containing protein 7.
What is the protein family that this protein belongs to?
Belongs to the ACBD7 family.
Protein: CDHR1_RAT
Sequence: MRRGPQVALVLGLLCIYLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPNFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVIVVTDANDEAPRFLQEPYNILVPENTPAGSSIFKVQAEDKDTGSGGSVTYFLQSLHSSKFTVDRHSGVLRLQAGATLDYEKSRAHFITVVAKDGGGRLRGADVVFSATTTVTINVEDVQDTAPIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRLLNESDGLFEINETSGAISVLQSPAQLRREVYELHVQVTEVNSSGSPAAQSTVPVIIRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITVNDSDQGANAKFNLRLVGPGGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKSLTFKLLAIEVNTPEKFSSTADIVIQLLDTNDNVPKFTSHYYIARIPENVPGGSNVVAVTAVDPDTGPWGKVQYSIYGTGSDLFLIHPSTGLIYTQPWASLDAEGTSRYNFYVKAEDMDGRYSLAEVFVTLLDVNDHYPQFVQSVQEKTMVLGTPLKIEATDQDAEEPNNLVDYSITRAEPVNVFDIDAHTGEIRLKNSIRSLEALHNITPSGEYSWSLQVQAKDRGSPSFSTTALLKIDITDTERLSRSSMAAFLIQTKDNPMKAVGVLAGVMAIVVAITVLISTATFWRNKKSNKVLPVRRVLRRRPSPAPHTVRIEWLKFRRAKAASKFILKEDPPNENCNNSRVGVTVPPRAPALPPPPKMASSTVAQQTVPTVSGSLTPQPSQQLPTPKPLGGPAQSSLVSELKQKFEKKSLGNKAYV
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).
What are the official names of this protein?
Cadherin-related family member 1, MT-protocadherin, Photoreceptor cadherin, prCAD, Protocadherin-21.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region (By similarity).
Protein: MIAB_PSEAE
Sequence: MAKKLFIETHGCQMNEYDSSRMADLLGEHQALEVTENAAEADVILLNTCSIREKAQEKVFSKLGMWRELKQQNPDLVIGVGGCVASQEGAAIRERAPYVDVVFGPQTLHRLPEMIDAARSTRKPQVDVSFPEIEKFDRLPEPRVDGPTAFVSVMEGCSKYCSFCVVPYTRGEEVSRPFDDVIAEVIHLAENGVREVTLLGQNVNGFRGLTHDGRLADFAELLRVVAAVDGIERIRYTTSHPLEFSDALIQAHAEVPELVKFIHLPVQSGSDRVLAAMKRNHTVLEYKSRIRKLKAAVPDICISSDFIVGFPGETEKDFEQTMKLVEDVGFDFSFSFIYSARPGTPAADLADDLPEEVKKQRLQILQSRIHQQGYEISRRMVGSTQRILVTDFSKKDPGMLQGRTENNRIVNFRCDNPRLIGQFAQVHIDDALPHSLRGTLIDSTLH
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: US10_PSHV1
Sequence: MRPLSRLHFPRGSLPLCPYSGSSAEAEAYQRLRGVRAASELWCELHDLAEHLLPIVSKRGRRPDDEAGRSLMLRNAADRLRASFVRAVELSKPSADAQDKGRSDGAGDKQKGGDAARDGGEMAGLSQLLFLPSPALHRPPIRVGPTEDCLNSDMTSSDAAVPHAYGSSSSSSDEAGVPGRRRSRRRRCVHAWRKENVEARARAQSNNLRAAVSAVLLDRWLPIGDARNTCTPPGELEERLLAAVLAAAHWCCLWHDSPCGAGSLYADIYAEDIFATGAPQR
What are the official names of this protein?
Virion protein US10 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae US10 family.
What are the subcellular locations of this protein?
Virion tegument. Host nucleus matrix.
Protein: PANB_ROSS1
Sequence: MRKTITDIQQMKVRGEPIAMLTAYDATIAALFDAAGVPMLLVGDSLGDNVLGFSSTVPVTIEDMVRHTAAVARGAQSALIVADMPFLTYATLEMAVAAARRLMQEGGAQAVKLEGGQAMVPIVRRLVECGVPVMGHLGYTPQSVHLFGKARVQGRSAAAARRMIEDALALEAAGAFALVLELVPAQLAAAITERLRIPTIGIGAGPHCDGQVQVFTDILGLRDDFKPRHTRRFAELAPLIRSAVAAYVAAVGERSFPTAEHSSRMDEAELREALEGLS
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAF5_DROME
Sequence: MSLEVSNINGGNGTQLSHDKRELLCLLKLIKKYQLKSTEELLCQEANVSSVELSEISESDVQQVLGAVLGAGDANRERKHVQSPAQGHKQSAVTEANAAEELAKFIDDDSFDAQHYEQAYKELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEKYKCDLDGYYIEGLFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRRQEVVADIVSKYLHFDTYEGMARNKLQCVATAGSHLGEAKRQDNKMRVYYGLLKEVDFQTLTTPAPAPEEEDDDPDAPDRPKKKKPKKDPLLSKKSKSDPNAPSIDRIPLPELKDSDKLLKLKALREASKRLALSKDQLPSAVFYTVLNSHQGVTCAEISDDSTMLACGFGDSSVRIWSLTPAKLRTLKDADSLRELDKESADINVRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLWSLLTWSCVVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQFHPNSNYVATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSNGSLVTTLLRHTSTVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHITVSHHQDENDEDVYLMRTFPSKNSPFVSLHFTRRNLLMCVGLFKS
What is the function of this protein?
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.  May play a role in helping to anchor Taf4 within the TFIID complex.  May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 5, TAFII-80, Transcription initiation factor TFIID 85 kDa subunit, p85.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TAF5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GSA_BORPD
Sequence: MSSNAQLFDRACRSIPGGVNSPVRAFRSVGGTPRFIKRAQGPYVWDEEDTRYIDYVGSWGPAILGHAHPDVVQAVREAALDGLSFGAPTRAEVELAEVLIERLPSLEQVRLVSSGTEATMTAIRLARGATGRAKIIKFEGCYHGHSDSLLVKAGSGLLTFGNPSSAGVPPEFVSHTLTLEYNNLAAVQAAFAQHGADIACVIVEPVAGNMNLIKPAAGFLQGLRDVCTQHGAVLIFDEVMTGFRVGPQGVQGLAGIKPDLTTLAKVIGGGMPVGALGGRADLMAHLAPLGGVYQAGTLSGNPVAVAAGLATLRLIAQPGFYEQLAAQTQRLTDGLRQRARAAGIPFAADAIGGMFGLYFQDSVPTSFAEVSAGDADAFKRFFHAMLDRGVHFAPSAFEAGFVSATHDNAVIDATLDAAEAVFAAMKG
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_SALRD
Sequence: MPDRNIVVLTAPSGAGKTTIAHRVLEAMPDMQFSVSATTRAARPDETDGVDYHFLSPEEFRARIDAGDLLEYEEVYPDQFYGTLRSEVEDRAEDGPVLLDIDVKGALNVKRIFGDDALILFVAPPSLDELQRRLEGRGTEDRESLQDRLDRVEQEMDRADDCDAVVVNDDLDPAVEETLTRIRQFLSS
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_PARUW
Sequence: MAVGKVKQIVGPTLDIEFPPGQLPNILNAIKIIDPKDQRELIAEVAMHLGDNQVRCIALSSTDGLVREAQAVDTEAPISIPVGSPTLGRLLNVLGQPIDEMGAIENAEISPIHKASPTFEEQDTQGVIFETGIKVIDLLCPYTKGGKVGLFGGAGVGKSVIVMELIHNIATHHGGYSVFCGIGERTREGNDLWLEMKESGILSKTSLVFGQMNEPPGARMRVGLTGLTMAEHFRDQEHQNVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLASEIGSLQERITSTKHGSITSVQAIYVPADDYTDPAPASIFPHLDAATTLSRQIAELGIYPAVDPLNSSSRILDPHVLGEEHYQVARQVQKVLQRYKDLQDIIAILGIDELSEEDQLTVSRARRIQKFLSQPFFVAETFTGKKGRFVKLPDTIKGFKMIVEGEMDNIPEQAFYMVGTIEEVFEKAEQMK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KTHY_RICB8
Sequence: MSKLKQGTFITFEGGEGIGKSTQCQMLYEYLKSQNIPVILTREVGGTNVAEKMREILVHTDLLPMSELLQAMAARYDHMVKKIIPALQAGNIVICDRFIDSTACYQGLELENGIELVYNLHKDLMPPLMPDLTFFIDVESSIAIERINSRNMSNKFDVRGLDFYNKIYDCFKGLSKKFPERIVTIKASDLNPEQVHELIKKHLNLI
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: 5NT1A_HUMAN
Sequence: MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ
What is the function of this protein?
Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:11133996, PubMed:7599155, PubMed:8967393, PubMed:34814800).  AMP is the major substrate but can also hydrolyze dCMP and IMP (PubMed:11133996, PubMed:7599155, PubMed:8967393, PubMed:34814800).
What are the official names of this protein?
Cytosolic 5'-nucleotidase 1A, cN1A, 5'-deoxynucleotidase, Cytosolic 5'-nucleotidase IA, cN-I, cN-IA.
What is the protein family that this protein belongs to?
Belongs to the 5'-nucleotidase type 3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LBP_MOUSE
Sequence: MKAGTGPLLSTLLGLLFLSIQGTGGVNPGVVARITDKGLAYAAKEGLVALQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQNCELRGSSLKLLPGQGLSLAISDSSIGVRGKWKVRKSFLKLHGSFDLDVKGVTISVDLLLGMDPSGRPTVSASGCSSRICDLDVHISGNVGWLLNLFHNQIESKLQKVLENKVCEMIQKSVTSDLQPYLQTLPVTAEIDNVLGIDYSLVAAPQAKAQVLDVMFKGEIFNRNHRSPVATPTPTMSLPEDSKQMVYFAISDYAFNIASRVYHQAGYLNFSITDDMLPHDSGIRLNTKAFRPFTPQIYKKYPDMKLELLGTVVSAPILNVSPGNLSLAPQMEIEGFVILPTSAREPVFRLGVVTNVFASLTFNNSKVTGMLHPDKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNAELAQGFPLPLPRHIQLHDLDFQIRKDFLYLGANVQYMRV
What is the function of this protein?
Plays a role in the innate immune response.  Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073).  Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity).  Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872).
What are the official names of this protein?
Lipopolysaccharide-binding protein, LBP.
What is the protein family that this protein belongs to?
Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule membrane. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.
Protein: POTA_NOSS1
Sequence: MNMAQTVTQNPRGVKTLLPLDVELRNVFKFFNQEPAVHGVDLDVRQGEFFSILGPSGCGKTTTLRLIAGFEQVDAGKLLIQGQPMTNIPPYRRPVNTVFQSYALFNHLNVWDNVAFGLRLKKSRKSEVESRVKEALKLVKMESLRSRFPSQLSGGQQQRVALARALVNRPAVVLLDEPLGALDLKLRKEMQVELSNLHKNLGLTFVMVTHDQEEALSLSDRIAVMNQGKIEQIGTPQEIYERPKTSFVADFIGDTNLFSGEITVLEAEYIQIVTKTGLTIVVARNEDTPAELLKPVVVSVRPEKIQLSLYPPSSLNNCFEGRLINVMYLGTHVNYVVQLINGMNINVLQPNTFGNLPDRETPIYAWWAESDCLAINQMTND
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PYRC_HAHCH
Sequence: MSDLVITRPDDWHLHLRDGDALATTVPATARLFSRAIVMPNLVPPVTHTAQAEAYRHRILSHVPAGAAFDPLMTLYLTNNTSPEEIVAARQSGIVYGCKLYPAGATTNSDAGVTDVANVFSVLEKMSDMGMPLLIHGEVVQADVDIFDREKRFIDETLTPLTERFPNLKIVLEHITTRDAVEFVNQAGSNVGATITAHHLLYNRNHMLVGGIRPHFYCLPILKRSEHQLALRDAAASGSDRFFLGTDSAPHPKEKKEAACGCAGCFTAPSALELYAEAFDELGALDKLEGFASLHGPTFYGLPINSGKVRLSKQEWTMPASMALGDSSIVPFRAGETIRWKAELL
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
Protein: ARCA_LISMH
Sequence: MKMEKALNITSEIGKLQTVLVKRPGSELENITPEYLESLLFDDIPYLKMMQKEHDFFVKTMQGSNIEVLYLEKLAAEALRAANNKESFLTKIIKESNQMDESALYVRDYLMSFDEEEMISKLMSGLKKSEIPERKKKHLNEMMDEQYPFFLDPLPNLYFTRDPAAVIGNGVTINKMFQPARRRESMFIELILKHHPRFSNQEIPVWSGREEPFSLEGGDELVLTEETILVGVSERTDARAVERLAESLFSRSPKIKRVLAVEIPETRSFMHLDTVFTMVNYAQFTIHPAIQNQQGELNIYILEKSENGLDITPRRDFKRVIAEVLGEPEVDFIPCGGEDVIVSAREQWNDGANTLAIAPGEVITYDRNQVSNDLLRSAGIKVHEVISSELSRGRGGPRCMTMPLSRENLK
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.