PharMolix/UniProtQA huggingface dataset:
Protein: PNP_COXBU
Sequence: MNKIRKTFQYGKHEVTFETGEMARQATGAVVVRMGDTVLLVSVVAKKEAEEGRDFFPLTVNYQEKTYAAGKIPGGYFKREGRPTEKETLTSRLIDRPLRPLFPKGFTNEVQVIATVLSVDSKVPTDIPAILGASAAIGLSGIPFNGSLGAARVGYRGGEYLLNPSLDELKDSALDLVVAGTRDAVLMVESEAQELPESVMLGAVLHGHQAMQVAIQAIAEFIQEAGGAKWEWEPPTVNTALEKWVVEKSEAPLKKAYQIQEKTARQAQIQAIRDQLLADRAAEREGEENAVNEHELAVIFHELERRIVREQILTGQPRIDGRDTKTVRPITVKVGVLPRSHGSALFTRGETQALVVTTLGTERDAQSIDDLDGDRQEEFIFHYNFPPFCVGEVGFMSGPKRREIGHGRLAKRAVVPVVPTLDKFPYVIRVVSEILESNGSSSMASVCGSSLALMDAGVPTKAPVAGIAMGLIKENDKYAVLSDILGDEDHLGDMDFKVAGTSNGVTALQMDIKIEGITKEIMEQALDQAKEGRLHILSIMNKVLDKPRSQVSDLAPQYVTMKINPEKIRDVIGKGGVVIREITEATNCAIDISDDGTIKIAAHTTEEGEAAKRRIEELTAEVELGKVYEGTVVKITDFGAFVQILPNTQGLVHISQIAQERVENVRDYLEEGQVIRVKVIEIDRQGRVRLSMKQID
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_HERAR
Sequence: MKVFYDKDCDLSLIKGKNVAIIGYGSQGHAHAQNLNDSGCKVTVGLRKGGASWDKVKNAGLNVAEVNDAVKAADVIMILLPDENIAQVYNENVAPHAKQGAVLAFAHGFNVHYGQVVPRADLDVIMIAPKAPGHTVRGTYSQGGGVPHLIAVYQDKSGVARDIALSYAMANGGGRAGIIETNFREETETDLFGEQAVLCGGAVELIKAGFETLTEAGYAPEMAYFECLHELKLIVDLIYEGGIANMNYSISNNAEYGEYVTGPRIVTEDTKNAMRQCLKDIQTGEYAKSFILENKAGAPTLISRRRLNAEHDIEQVGAKLRAMMPWIAKNKLVDQSKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: UL87_HHV6U
Sequence: MQHTGNCETLIVNSCFGSTCARSIPVFIDSCDLTAEVSRDEETRLARSMPVVLEKIESIIEKIFQTSGPNIVHDKDRAKIALCRLLLGPVAVPCFCEEWDTNDYLSKSGCKCIGPILYIHTSRCRCSDIPVFKFSIMKDYYASHVFRGLLSLKEWNTHLPNVLCTCELSMSDRYVATVYPKQNSIYLEYYPYFLCYLCRHLTVIEIEQCTNDLISLLGPKVAQRVIIHFKLLFGFRHKPHIGTVDSWFWENFFMLELHKLWLTVVKHNRVTTDFFNVVYEKIQNYKQYAIKTLRMSSKAVPAIQRLCLAKFKQQLLYLNIKVTVKKNKREMCLNGFVYGKTLYVVESSQLIFRNLLLLYYDYSLPDECKTNEENVLTAHYIRVISRLSFKRSRSALPPGVRPDFIFVAQQPKRKELPNVPGGIDFAEITSVRHGAVTLNAFNTNKVMNLKATISKRANFVYHRIPKTMTHSFVMYKHTFKEPAFTVSTFVSNDDLDMSSLNINIRGPYCDFLYALGVYKMHVSIRDLFLPAFVCNSNNSVDLQGLENQDVVRNRKKKVYWITNFPCMISNANKVNVGWFKAGTGIIPRVSGEDLQNVLLQELNNVREIPGLVFDMDLHQLLVLLEQRNLHQIPFLVKQFLIFLRLGLLMGYGHSRRNKVHDIMLHLISNGLFDFNKNSVANTKIKHGCALVGTRLANNVPKIIARQKKMKLDHMGRNANSLAVLRFIVKSGEQKNKTVFIKLLEYLAETSTAINTRNEVARLLQTLTAKVKT
What are the official names of this protein?
Protein U58.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL87 family.
Protein: TRAE_PENCR
Sequence: MAAPALPVSLTPALSDRDAIADALYRGVIAFDTADEVLFKSALTEDAVLVLNGTVMEGYDAIYSGCYVNIAKMDTNHFLTNMRVNITEESKAQVSCSALSQHYRGGEGMKPGSDFLLAGGLYAVELVKDAGDGLWKIKHWTLKTTWGQGDWAVFGK
What is the function of this protein?
Part of the tra gene cluster that produces terrestric acid (PubMed:30811183).  The clavatol biosynthesis cluster cla and the terrestric acid cluster tra are both involved in the production of peniphenones and penilactones (PubMed:30811183).  The non-reducing PKS claF is responsible for the formation of clavatol from successive condensations of 3 malonyl-CoA units, presumably with a simple acetyl-CoA starter unit, and 2 methylation steps (PubMed:30811183).  The esterase claE probably collaborates with claF by catalyzing the hydrolysis of ACP-bound acyl intermediates to free the ACP from stalled intermediates (By similarity).  The clavatol oxidase claD then converts clavatol to hydroxyclavatol (PubMed:30811183).  Spontaneous dehydration of hydroxyclavatol leads to the accumulation of the highly active ortho-quinone methide (PubMed:30811183, PubMed:31860310).  On the other hand, the PKS-NRPS hybrid traA is involved in the formation of crustosic acid, with the help of traB and traD (PubMed:30811183).  The polyketide synthase module (PKS) of traA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 3 malonyl-CoA units (PubMed:30811183).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with L-malic acid (PubMed:30811183).  Because traA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase traG (By similarity).  Crustosic acid undergoes decarboxylation and isomerization to the terrestric acid, catalyzed by the 2-oxoglutarate-dependent dioxygenase traH (PubMed:30811183).  Both acids are further converted to the 2 gamma-butyrolactones (R)-5-methyltetronic acid and (S)-5-carboxylmethyltetronic acid, with involvement of the cytochrome P450 monooxygenase claJ (PubMed:30811183).  Spontaneous addition of the methide to these gamma-butyrolactones leads to peniphenone D and penilactone D, which undergo again stereospecific attacking by methide to give penilactones A and B (PubMed:30811183, PubMed:31860310).  TraE seems not to be involved in the biosynthesis of peniphenones and penilactones in the conditioons used to study its function (PubMed:30811183).
What are the official names of this protein?
Terrestric acid biosynthesis cluster protein E.
Protein: GALT5_DROME
Sequence: MTFSTFTRKMRGRMRSNTCRIVLLTSLVWVIFDFVLIARYSDCIGKDGWRCKRSGEYDVELPNAERLVDDNQLVDDNEINTEKSLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGKPGEMGKPVKIPADMKDLMKEKFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRIWQCGGILEIIPCSHVGHVFRDKSPYTFPGGVAKIVLHNAARVAEVWLDEWRDFYYSMSTGARKASAGDVSDRKALRDRLKCKSFRWYLENVYPESLMPLDYYYLGEIRNAETETCLDTMGRKYNEKVGISYCHGLGGNQVFAYTKRQQIMSDDLCLDASSSNGPVNMVRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDDANTPLLRPCSYGKGQQWLMESKFKWQAH
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714, PubMed:18669915).  It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties.  Prefers EA2 as substrate (PubMed:12829714).  In the larval midgut, required for O-glycosylation of apical and luminal proteins within copper cells enabling proper gut acidification (PubMed:22157008).
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase 5, pp-GaNTase 5, Protein-UDP acetylgalactosaminyltransferase 5, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: UXUA_SHIF8
Sequence: MEQTWRWYGPNDPVSLADVRQAGATGVVTALHHIPNGEVWSVEEILKRKAIVEDAGLVWSVVESVPIHEDIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRPGAEADYTEEEIAQAAERFATMSDEDKARLTRNIIAGLPGAEEGYTLDQFRKHLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVDTVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTMREDNPKTFHEAAHLNGDVDMYEVVKAIVEEEHRRKAEGKEDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQRAFFSR
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: ATG2_YEAS7
Sequence: MAFWLPQNIQKRLLLYVLQQISLFSNIDLSNLDVSIGSKSHFSFHDVNLSLDDLNIPNVQINEGIVDELVLKLTVSGGVEIDGSGLRFIMTPLYSSGSQELHSDFLVKSIQDLTNSMLQFSDPLTTYNRYKEDDISSSDSSSDLNSNIEASKPAANGSYTLQNMRNKALNVALAKLKIALKDVTIRFIVNDRDPSDNIVEVHLESIQLITTDANLRHINIENITISSIQKQAVPDSPVHPFNNDDLSQSVYLSKMEATSLYMSAMEEQSNEDPSEPQVTQEEQENDKCKESLMEINNLNIAFKGLSSVNDLRMSNIVIDIQDVHLAIHKIVEIKNSTLKNIIDIIVTHLDANESFSCQDSQSPSPDKQEPSALSSVDIKCIYLNLGQDITVILKSFKLEQKENNSLAFSLGSFYSNSSPLTISHKTKPLLTGEQTPQSIALNMGDELDIIISHDGIAHFFKIFQFVSKCMSFYQNKSKGMMPQIASDTKRTVQLTSKAVKLSLKFPYFLLCFQVSPFIYDSNRELYIELVDVFKKLPSRCTKILTMSSITISNLQSPLQLGSYDDTLKEALIYSSVHAIIKEVIFNEEYSGIVQLVEDISAFGKLFTDSKNSECTGKSKSKRGSFLQRSVRVLNSSRFVYKQSLSANFSLKIDSMKLKVSEIIGPQFGSVEALLSNNFFAITDDSQIVYFTKNLKVERKTPSLLEPQEIMSVVLNKAVNEPVLYVHRRANGKLKVIFNNIRIHYYARWLEILKKNIGPDNASSKDEPVAQKLSKKQPTSGFPWELKCLDCSLILHPFRLKSVMVIVLDNLTTGGSSFIPQAKLLSKANTLFLIDDYQNFKIQKDKNWPSLINFYAGQGFSAIGKIDTLNFLINKSDGALLLDCKIEQVGLSLCADSFQTFCQLCIDLKYPQTFPDEEKFRTQLKNPIDVFKDIDCDLFNSAFIRENNHQNDYDSVHLVDSFLDKTHEFNNGARSKLSSQGSYEMDSSSGTATGGILLPHESYLDSAQPKEEDTPPIASKEQERDVDIRGSIDIEKVVIKLFDGYDWKYTRKFIANTVEKLDKELSKAEASSSKSNVPQSEANIFDSIYISANKNNVTDLRRNLDGEIQGVQNSFSDVSKVNLRPSKHYKALIQLNKVHVNLKNYRVDEPDESNSDNSTDVLNRCVVSVYEFEIIDNVPTSTWNKFVTLLKHEPWPHSSPMFLLDLEFIRPIDFLQAVELVMQLNVAPLRLHVDQDTLEFLIRFLGFKDKRFELIDEYPDIVFIQKFSTNSIKLRLDYKPKKVDYAGLRSGQTSELMNFFTLDGSKIILKSVVLYGLNGFDELNNKLKAIWTPDITKKQLPGVLEGLAPVRSFMAIGSGVKTLVTVLMSEYRQEGHLGRSLKKGGNVFLKTTTGDFVKLGVKLTSGTQAILENTEELFGGVGSNGRVYDASKFGSADGADSDTAAVLDLDTLFEEDQLVGSKYSRIRDHEPTAVVIDMSSPGDHNEPTIVSLYADQPLDLPTGLKEAYSSLEKHMHIAYDAVWRAKGQMKDDKRGGPSAAAVYVARAAPVAIIRPLIGATEAVSKTLQGIANQVDKTHNEQINDKYKSNRTDS
What is the function of this protein?
Lipid transfer protein required for autophagosome completion and peroxisome degradation.  Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion.  ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region.  The latter binding is assisted by an ATG18-PtdIns3P interaction.  ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
What are the official names of this protein?
Autophagy-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the ATG2 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: SIR42_CAEEL
Sequence: MARKYVPHTTELCENSLKKFKSLVGTVDKLLIITGAGISTESGIPDYRSKDVGLYTKTALEPIYFQDFMKSKKCRQRYWSRSYLNWPRFAQALPNFNHYALSKWEAANKFHWLITQNVDGLHLKAGSKMITELHGNALQVKCTSCEYIETRQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLGSEQGFKIPECLNCGGLMKTDVTLFGENLNTDKIKVCGKKVNECNGVLTLGTSLEVLSGYQIVNHAHMQNKPIFIVNIGPTRADQMATMKLDYRISDVLKEM
What is the function of this protein?
NAD-dependent protein deacylase.  Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.  Plays a role in oxidative stress resistance (PubMed:23438705).  Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2 (PubMed:28820880).  Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked (PubMed:28820880).
What are the official names of this protein?
NAD-dependent protein deacylase sir-2.3, Regulatory protein SIR2 homolog 3.
What is the protein family that this protein belongs to?
Belongs to the sirtuin family. Class II subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix. Mitochondrion.
Protein: DDL_LEPBJ
Sequence: MAKIAVFFGGSSTEHSISIRTGCFICRTLHTMGHSVKPILLTQDGGWVVPLQYRISIPYEAVNSSDLFEEEFQKTNGVSKMDFISNLDADIVFLGLHGGKGEDGSIQGFLRVLGVPYTGSGVAASALAMDKTRANQIFLQSGQKVAPFFEVEKLGYTNSPEETVIKLMSLGFPQFLKPVEGGSSVSTYKITNQEQLSRQLALIFESDSKVMSQSFLAGTEVSCGVLERYRNGKLERIALPATEIVPGGEFFDFESKYKQGGSREITPARISKQEMTRVQELAIDAHTSLGCRGYSRSDFIIVGGEPHILETNTLPGMTETSLIPQQAKAAGITMEEVFADLIEIGLKHSIH
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_COXB1
Sequence: MSLKIVFAGTPQFAVPTLRALIDSSHRVLAVYTQPDRPSGRGQKIMESPVKEIARQNEIPIIQPFSLRDEVEQEKLIAMNADVMVVVAYGLILPKKALNAFRLGCVNVHASLLPRWRGAAPIQRAILAGDRETGISIMQMNEGLDTGDMLAKSACVISSEDTAADLHDRLSLIGADLLLESLAKLEKGDIKLEKQDEASATYASKIQKQEALINWRKSAVEIARQVRAFNPTPIAFTYFEGQPMRIWRATVVDEKTDFEPGVLVDADKKGISIAAGSGILRLHQLQLPGKRVCSAGDFINAHGDKLIPGKTVFG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: POTA_STAES
Sequence: MNPLLSFKDVSKGFEDVQILNEINIDIEPSYFYTLLGPSGCGKTTILKLIAGFEYPDSGDIIYKDKPIGKMPPNKRKVNTVFQDYALFPHLNVFDNIAYGLKLKKLSKSEIKRKVTEALQLVKLSGYEHRQIQGMSGGQKQRVAIARAIVNEPEILLLDESLSALDLKLRTEMQYLLRELQSRLGITFIFVTHDQEEALALSDYIFVMKDGKIQQFGTPIDIYDEPVNRFVADFIGESNIVHGTMVEDFVVNIYGQNFDCVDMGIKENKKVEVVIRPEDISLVSQNDGLFKAKVDSMLFRGVHYEICCKDRKGYEWVIQSTKKANVGSEVGLYFEPEAIHIMVPGETEEEFDKRIESYEDYHHA
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYRR_DEHMB
Sequence: MAQKVILGAEDIRRTLARIAHEILERNQSSRDLVIIGMYTRGVPLANRLAENILRFEGLEIPVGTLDFSLYRDDLDSQRFHPTIKNTDIPFSINNKIVVLVDDVLFTGRSTRAAMDALIDYGRPKAIQLAVLVDRGHRELPVRADYIGKNIPSARDEKIKVRLTETDGQDEVLILDDEAGEV
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: PLD3_XENTR
Sequence: MNPKVEYKQIQSHDEAENQVLQHECHQAKARKYYRCAVVIAIIITLLFCVLASQLLLFPLFSITSQTTTEIVLNKDIQCDDQCRFVLVESIPEGLVYDANATINPSIFQSWLNILTSAKSSVDIASFYWTLTNEDTQTQEPSAHQGELILQELLNLKQRGVSVRVAVNPPDSPLRAKDISALKDSGADVRVVDLPKLTDGVLHTKFWVVDSEHFYIGSANMDWRSLTQVKELGATIYNCSCLAEDLKKIFEAYWILGLPNATLPSPWPVNYSTPYNKDTPMQVMLNSTASQVYISSSPPPLSATGRTDDLQSIINIIDDAKKFVYISVMDYSPTEEFSHPRRYWPYIDNHLRKAVYERNVNVRLLISCWQNSRPSMFTFLRSLAALHSNKSHYNIEVKIFVVPATEVQKKIPYARVNHNKYMVTDRVAYIGTSNWSGDYFIHTAGSALIVNQTQSVGTSDTIQMQLQAVFERDWNSNYSRTFNTLSSWKEKCIF
What is the function of this protein?
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity).  Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity).  May be important in myotube formation.  Plays a role in lysosomal homeostasis.  Involved in the regulation of endosomal protein sorting (By similarity).
What are the official names of this protein?
5'-3' exonuclease PLD3, Choline phosphatase 3, Phosphatidylcholine-hydrolyzing phospholipase D3, Phospholipase D3, PLD 3.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Lysosome lumen. Early endosome membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Note=Localizes to ER-associated vesicles in differentiating myotubes. The soluble form in lysosome arises by proteolytic processing of the membrane-bound form.
Protein: EXGB_EMENI
Sequence: MKFILPLFTSLPVALAWLPGIDKDIYSAAGTNIFNVTSASSKRWLPASKKIRGVNLGSHFVIEPWMASMAWSNMGCSGQRSEFDCVMALGQETADQAFADHWGSWITQDDINQMVQYGLNTIRIPVGYWLKEDLVYADSEHFPKGGIGYLEDVCGWASDAGMYIIIDLHGAPGAQQPKQPFTGQYAPNPGFYQDYQYDRALEFLEWMTTSIHQNNKFRNVGMLEIVNEPVQNADQASSMINSYYPSAFTRIRNTESSLGITSNNYLHIQMMNEKWGSGDPTQSLTDNYFAAYDDHRYVKWDSSVAVDKESYISASCVDDRGGNWPTIVGEWSLSVPDNVEHTADWEPSSNTDFYARWFAAQAIAYEKQEGWVFWSWKAQLGDYRWSYKDAVDAGVIPKDLDSIYDYSPC
What is the function of this protein?
Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall.  Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.
What are the official names of this protein?
Glucan endo-1,6-beta-glucosidase B, Beta-1,6-glucanase B, Endo-1,6-beta-D-glucanase B, Endo-1,6-beta-glucanase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
What are the subcellular locations of this protein?
Secreted.
Protein: H2A2_ORYSJ
Sequence: MAGRGKAIGSGAAKKAMSRSSKAGLQFPVGRIARFLKAGKYAERVGAGAPVYLAAVLEYLAAEVLELAGNAARDNKKTRIVPRHIQLAVRNDEELSRLLGTVTIASGGVMPNIHNLLLPKKAGGSAKAAAGDDDN
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Probable histone H2A.2.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PYRF_BRUA1
Sequence: MTTELHDDASGRLIVGLDVPTIAEAEKVVEELGNAVSFYKIGYQLVFAGGLDFAKSLVAARKKVFLDMKLLDIDNTIAKGVENVAKMGVSMLTLHAYPKAMRAAVEAARGSDLCLLGVTVLTSMDNADLREAGYFDNAETLVLKRARQAHEAGMGGIVASAVEAQAIRQAVRPDMAIVTPGIRPAGSEKGDQKRVMTPADALRAGASHLIVARPIVGAPDRKAAALAILKEMRSIGRS
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: ACRBP_MOUSE
Sequence: MMNLAAGFLLMLLEVLLLPGTPLSAEESPASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPPTSMTTPIVSHATATEHQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQRKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEAGLESVSRLQSDSEPKFQSQSLSSNPSFFTPRVREVESAPLMMKNIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHMETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQKCDASHKIPFISPLLSAQSISTGNQARIPDKGRFAGLEMYGGLSSEFWCNRLAMKGCEDDRVSNWLKAEFLSFQEGDFPTKICDTNYIQYPNYCSFKSQQCLLRNQNRKMSRMRCMLNERYNVLSLAKSEEVILRWSQEFSTLAIGQFG
What is the function of this protein?
Rodent specific isoform that participates in the formation of the acrosomal granule into the center of the acrosomal vesicle during early spermiogenesis (PubMed:27303034).  In the fertilization process promotes ACR release from the acrosome during acrosomal exocytosis (PubMed:27303034).
What are the official names of this protein?
Acrosin-binding protein, Acrosin-binding protein, 60 kDa form, Proacrosin-binding protein sp32.
What are the subcellular locations of this protein?
[Isoform 2]: Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Colocalized with pro-ACR in the acrosomal granules of early round spermatids. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome. Secreted. Note=Highly enriched in acrosomal granules of round spermatids, and spread over the apical end of the nucleus in elongating spermatids. Colocalized in the acrosome of epididymal sperm with pro-ACR.
Protein: RL32_LEPBL
Sequence: MAVPKRRKSKSKVRTKRAHHAIGKPNLVPCPNCNVYRLPHRICPTCGFYKTGIVLEPKVKKPKEEN
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: WTF9_SCHPO
Sequence: MKNNYTSLKSPLDEEDELKTDHEIDLEKGPLPEYDSEEEGALPPYSDHALVNNPPNTHRENHSSGTTDNSSPLLIKLLISFTSIILFNAPAVCYLKYKDAFFKNYGAVEWTLFGFWCFVCTLALIFLTYFYETWTKAVKVTVISLAQCVKVTAVFLAKCVKVTAVGLYNSREKWVVIIWLLWVVICYTLFLRAKFGNLNLDKALICSTCSISAALLLFLLYVRLPFWTLKHMFSGLFQVLGVQSCVVIVQKGLMHLFDKHIDGTGYEIEASSLFVIGNFLFFYEMECPGALKRMPKFIRNGIASFLGGIANAIGGANDNNDIPLEETEAESEV
What is the function of this protein?
Acts as a suppressor component of the dual wtf meiotic drive system, and can suppress but not confer meiotic drive by compatible poisons (By similarity).  Wtf meiotic drive systems promote unequal transmission of alleles from the parental zygote to progeny spores by encoding a poison and an antidote from the same locus; the poison is trans-acting and forms toxic aggregates in all spores within an ascus, wherease the antidote is spore-specific and targets aggregates for degradation by the vacuole (By similarity).  Meiotic drive by wtf systems therefore lead to poisoning of all progeny that do not inherit the dual poison/antidote allele, or express a compatible antidote (By similarity).
What are the official names of this protein?
Meiotic drive suppressor wtf9.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein.
Protein: CVFB_STAAC
Sequence: MALDKDIVGSIEFLEVVGLQGSTYLLKGPNGENVKLNQSEMNDDDELEVGEEYSFFIYPNRSGELFATQNMPDITKDKYDFAKVLKTDRDGARIDVGLPREVLVPWEDLPKVKSLWPQPGDYLLVTLRIDRENHMYGRLASESVVENMFTPVHDDNLKNEVIEAKPYRVLRIGSFLLSESGYKIFVHESERKAEPRLGESVQVRIIGHNDKGELNGSFLPLAHERLDDDGQVIFDLLVEYDGELPFWDKSSPEAIKEVFNMSKGSFKRAIGHLYKQKIINIETGKIALTKKGWSRMDSKE
What is the function of this protein?
Contributes to the expression of virulence factors and to pathogenicity.  Involved in the production of hemolysin, DNase, protease and protein A (By similarity).
What are the official names of this protein?
Conserved virulence factor B.
What is the protein family that this protein belongs to?
Belongs to the CvfB family.