PharMolix/UniProtQA huggingface dataset:
Protein: XYLA_BIFLD
Sequence: MGLWDVDKIEYVGRAKGPKEDFAFHYYDADKVVAGKKMKDWLRFGVAWWHTFNQELVDPFGTGTAHRPYYKYTDPMDQALAKVDYAFELFQKLGVEYFCFHDRDIAPEGDTLRETNANLDKVVDKIEENMKSTGVKLLWNTSSLFTNPRFVSGAATSPFADIYAYAGGQLKKSLEIGKRLGAENYVFWGGREGYENLWNTEMKRETDHIAKFFHMCADYAKEIGFEAQFLIEPKPKEPTLHQYDFDAATAIEFLRNHDLTDVFKLNLEGNHANLAGHTYQHEIRVARESGFLGSLDANQGDKLIGWDMDEFPTDLYETVAVMWEVLQAGSIGPHGGLNFDAKPRRTSFYEEDLFRSHIAGMDTYAAGLLVADKMNQDGFIQDLMAERYSSYDSGIGKDIDEGNVTLADLEAYSLDKPQSELIAATKSDHLESVKATINNYIIDALSEVE
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_FRATF
Sequence: MGLSVVILAAGKGSRMNSNKPKVLQTLAAKTLIEHVVSSVEKLNPDNIVVVTGHLKEQVEDALQGRNITFVYQQQQLGTGHAVLQALPYLKEQKVLILYGDVPLISTEVLENLVDTTNDDDLGVLTAFVENPQGLGRIVRDKFGAVTEIVEEKDANDIQRQIKEINTGIYCVHKNLLQKWLPEIKANNVQKEYYLTDIITFAKADHVSINVTHPINEFEILGVNDRTQLASLERVWQRNVAEKIMAKGVSIADPNRFDVRGNLDVGKDCWIDINVIIKGNVKLGNNVVIGANCILKNCIIEDNVRIKSNSMVDGSIIREGAIVGPFARVRPECDVKEGAVIGNFVEAKKTILGKGSKASHLTYLGDSEIGANCNIGAGVITCNYDGVNKHKTVIGDYAFIGSDSQLIAPVNIGQGATVGAGSTIVKDVPADNLAISRARQRHIDTWQRSVKKTDK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPSB_RALSO
Sequence: MTQNLSQPPAVNAPESELDLVRYLDVLVANRWLIAGIAAVVMLLGATYAFLARPVYEADVLVQVEDNPNSAKSLLGDVSSLFDVKTDANAEIEILRSRMVVGKAVDNLHLYITAKPHYFPLIGAWVASRAKQLSEPGLFGLGGYTWGTELIDVDGFDVPEALEGQPFKLTALGNGRYRLENKSLDTPIEGVVGEPLEAKQSVGTIQLLVNTLAAKAGAAFELQRDSRLKTLEMLQDKLKISEKGKQSGIIGASLEGKNPALTAAIMNQIATEYVAQNIKRKAEEAERSLVFLDGLLPQLKLQLERAEMKYNEMRNLRGTFDLSEEGKAFLQESVTTETSLQELKQKRAELLTRFTASHPGVQAIDQQIAVMSGKVGAMTRRLKSLPNIEQDTVRLMRDVQVDNDLYVSLLNDMQQLKLVKAGKVGNVRLVDGAAVPEEPVKPKKLTVTALAGVLGVVLGVVAAFVRNTLFGGITEPQDIEEHTGLSVYATVPLSDVQIDLSSQLTTHKRGQYLLARRVPDDPSIESLRSLRTALQFAMQDSGNNLVVLTGPTPGVGKSFVSANLAAVIATGGKRVLLVDADMRKGYLHQYFGKDRKPGLLDLLAGDRSIEQVVHREVVPGLDFIATGLFPHNPSELLLNPRMVELMDTFRAQYDLVLIDTPPVLAVTDTAILAARAGTVLMVTRFERSTLGEIRETIKQLQHANVEVRGVVFNALDPNTYRYGYGSRYGRYRYVQYGYTSKPSAEAEAESA
What is the function of this protein?
Probably involved in polymerization and/or export of exopolysaccharide EPS I which functions as a virulence factor.  May be involved in an ATP-dependent process in the pathway for EPS I production, possibly export of the trimeric repeat units across the inner membrane or their polymerization (By similarity).
What are the official names of this protein?
Putative tyrosine-protein kinase EpsB, EPS I polysaccharide export protein EpsB.
What is the protein family that this protein belongs to?
Belongs to the etk/wzc family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNB2_ADE02
Sequence: MASREEEQRETTPERGRGAARRPPTMEDVSSPSPSPPPPRAPPKKRLRRRLESEDEEDSSQDALVPRTPSPRPSTSTADLAIASKKKKKRPSPKPERPPSPEVIVDSEEEREDVALQMVGFSNPPVLIKHGKGGKRTVRRLNEDDPVARGMRTQEEKEESSEAESESTVINPLSLPIVSAWEKGMEAARALMDKYHVDNDLKANFKLLPDQVEALAAVCKTWLNEEHRGLQLTFTSNKTFVTMMGRFLQAYLQSFAEVTYKHHEPTGCALWLHRCAEIEGELKCLHGSIMINKEHVIEMDVTSENGQRALKEQSSKAKIVKNRWGRNVVQISNTDARCCVHDAACPANQFSGKSCGMFFSEGAKAQVAFKQIKAFMQALYPNAQTGHGHLLMPLRCECNSKPGHAPFLGRQLPKLTPFALSNAEDLDADLISDKSVLASVHHPALIVFQCCNPVYRNSRAQGGGPNCDFKISAPDLLNALVMVRSLWSENFTELPRMVVPEFKWSTKHQYRNVSLPVAHSDARQNPFDF
What is the function of this protein?
Plays a role in the elongation phase of viral strand displacement replication by unwinding the template in an ATP-independent fashion, employing its capacity to form multimers.  Also enhances the rate of initiation.  Released from template upon second strand synthesis.  Assembles in complex with viral pTP, viral pol, host NFIA and host POU2F1/OCT1 on viral origin of replication.  Covers the whole ssDNA genome during synthesis.  The complementary strand synthesis induces its release from DNA template.  May inhibit cellular transcription mediated by the interaction between host SRCAP and CBP.
What are the official names of this protein?
DNA-binding protein, DBP, Early 2A protein, Early E2A DNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E2A DNA-binding protein family.
What are the subcellular locations of this protein?
Host nucleus. Note=Accumulates in infected cells.
Protein: PSA6_SOYBN
Sequence: MSRGSGGGYNRHITIFSPEGRLFQVEYAFKAVKAAGITSIGVRGKDSICVVTHKKVPDKLLDNTSVTHLFPITKYLGLLATGMTADARTLVQQARNEAAEFRFTYGYEMPVDVLAKWIADKSQVYTQHAYMRPLGVVAMVLGIDDEYGPQLYKCDPAGHYFGHKATSAGLKDQEAINFLEKKMKNDPSFTYEETVQTAISALQSVLQEDFKATEIEVGVVRKDNPEFRVLTTDEIDEHLTAISERD
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity (By similarity).
What are the official names of this protein?
Proteasome subunit alpha type-6, 20S proteasome alpha subunit A, 20S proteasome subunit alpha-1, Proteasome iota subunit.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL28_MYCGE
Sequence: MAKKDQLTLRGPLYGNNRSHSKTITRRKWNVNLQSCKIKDTNGKVTRILVSTKTIRTLKKQNRF
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: EXO70_CANAL
Sequence: MSYNLDVDEADVAVLNQNLIRSKELFESIGKSLHKISTKSQTASSTINPVLKQVNQLTTNKHEVENGLKLLQEVSENASKINDLENLLNNSIENSPGGIKSYLINLNQSKNLLSQIKTQSKFKQFKGILYNFENLIDRSETKVQKYYQDLINGKDSRAIIDKRDEIKLIFQYFSNPQTKSTSNSGGNEEYVTKLYVRARSKRLIEKLKPIESSTKPAVKANANIPYEKGTNGITKYTDVLSGEIEQELIILNECQLSTHLIGPIVEESISRYNGIINKYNQVYFKTPQEIVDNVILILEVLNNLIDFKVKLKQIGLNRTLEQSNFINTFEQYLETNSVIFKEFIQAIDNRFQNLGKFNEINTQEVIVELMSKLRRLSEFKLALLQLIKNYSIGQWLVSQPPMRFVNVFSSVIPNSQPQANSDGEEDEVIQEYLLSSFYSDVIDAIMINIEIGLKKNTSGGDSLPSSSSTSASTNATSGTSSLSLNKKSTQGFILIKNLFMLESIVNRSQYLYQSLGSLGEERILRLKNRFLKLFLDDWSHASYIIIRDMTTIATQSAQHQQSQQQSSNTIGTGGGTVTNLSNKEKDQVKDLFKNFNESFEEALFNYQKYNFGDAILKKYLSNEIKKLILNTYFKLYDKYGNSDFTKNKSKYVKYDKLNFEKLLNERL
What is the function of this protein?
Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis.  Also plays a role in the assembly of the exocyst (By similarity).
What are the official names of this protein?
Exocyst complex protein EXO70.
What is the protein family that this protein belongs to?
Belongs to the EXO70 family.
What are the subcellular locations of this protein?
Bud. Bud neck.
Protein: ICP27_HHV1E
Sequence: MATDIDMLIDLGLDLSDSDLDEDPPEPAESRRDDLESDSSGECSSSDEDMEDPHGEDGPEPILDAARPAVRPSRPEDPGVPSTQTPRPTERQGPNDPQPAPHSVWSRLGARRPSCSPEQHGGKVARLQPPPTKAQPARGGRRGRRRGRGRGGPGAADGLSDPRRRAPRTNRNPGDRPGAGWTDGPGAPHGEAWRGSEQPDPPGGPRTRGVRQAPPPLMTLAIAPPPADPRAPAPERKAPAADTIDATTRLVLRSISERAAVDRISESFGRSAQVMPDPFGGQPFPAANSPWAPVLAGQGGPFDAETRRVSWETLVAHGPSLYRTFAGNPRAASTAKAMRDCVLRQENFIEALASADETLAWCKMCIHHNLPLRPQDPIIGTTAAVLDNLATRLRPFLQCYLKARGLCGLDELCSRRRLADIKDIASFVFVILARLANRVERGVAEIDYATLGVGVGEKMHFYLPGACMAGLIEILDTHRQECSSRVCELTASHIVAPPYVHGKYFYCNSLF
What is the function of this protein?
Multifunctional regulator of the expression of viral genes that contributes to the shutoff of host protein synthesis and mediates nuclear export of viral intronless mRNAs.  Early in infection, this immediate early (EI) protein mediates the inhibition of cellular splicing.  This results in the accumulation of unprocessed 3'end pre-mRNAs which can't be exported from the nucleus.  Cellular protein synthesis is thereby shut off early after virus infection.  Later in the infection, it helps recruit cellular RNA polymerase II to viral replication sites and promotes the nuclear export of viral intronless mRNAs by interacting with mRNAs and host NXF1/TAP.  ICP27 binds to NUP62 which may provide facilitated viral mRNA export and may compete with some host cell transport receptors for binding and inhibit cellular nucleocytoplasmic transport pathways.  Also stimulates translation of viral transcripts.  Repression of host gene expression blocks the cell cycle at the G1 phase and prevents apoptosis.  Seems to silence the 3' splice site of the promyelocytic leukemia (PML) intron 7a, thereby switching PML isoforms from PML-II to PML-V.  This could be linked to the accelerated mRNA export induced by ICP27 which might not provide sufficient time for PML pre-mRNA to be spliced in the nucleus (By similarity).
What are the official names of this protein?
mRNA export factor, Immediate-early protein IE63, Infected cell protein 27, ICP27.
What is the protein family that this protein belongs to?
Belongs to the HHV-1 ICP27 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Protein: YXT1_CAEEL
Sequence: MFAPHTNIMSIARVLIIIASISVICITLFISRPVTRESSIIIAPKTRDMRAEQIRLFALNAMVKANSHTLPPRSKNISAKNLCSRRMTCAPHNRRYETMLKVSPKYKMVNCVVQKSMSTMMTGAMCYLYDEKAYADSGRTFDDEFSTRFCKNKNEFSSVNAVRDAYNISFVKTDWLFSMITRDPIDRFVSGYVDRCVRISQKNETGQCNGCGLNMTCFIENEYKRLMEISFKRKTHRTMEDAHFFPQIWHCDLNEDLEFFEFIQYSNNPETTMMPQLEEMLKRQKVPSDSIRFIKNELLYKKSSHSTTGTPASRFYRSRYS
What are the official names of this protein?
Uncharacterized protein C18B2.1.
What is the protein family that this protein belongs to?
To C.elegans C41C4.1 and C18B2.2.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MEND_VIBC1
Sequence: MSVDQAVLNRIWSETILTELNRFGVNHVCIAPGSRSTPLTVEAADNPNFTIHTHFDERGLGFMALGLAKASKEPVALIVTSGTAVANLLPAIAEAKLTGEKLVVLTADRPVELVGCGANQAINQLGIFAEHVSDSLNLPSPTLSTPLNWLLTSVDEVMFTQRLRGSAVHINCAFPEPLYSNTDKSTYQGYLDTVAGWRDSKVTYCQRFNPKTSSAIPSCGDNKGLVVIGSLPLIQAQAARTFAEQMGWPVLADPQSGVSSDWAHFDLWLQNPRMASQLDDCDLIVQFGSRIISKRFNHWLEKHVSRNQQGGDTQYWFVSPRLDRDNQSHLPQWHWAEQPSAWVERTSGFSSEHAGWADKLAADIKQVTQHAKGLFISDPKSELSEIALAIDVAERAQGVDLFVGNSLFVRLIDMFGKLDNTEVFTNRGASGIDGLFATASGVQRARNNPMLMFIGDTSALYGLNSLALFTHSELPSVLVIANNDGGAIFDLLPVPQEHRESFYQMPHGYEFEHAAKQFGLQYRKPSSLAEYQSLVSEHFASGQGALVVEVQTPSNQAVEHLKSFDKNLHALF
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: HEM1_RICTY
Sequence: MSYYDTIFNKHIDKIKSEGRYREFKSLKRQADNFPFAEYEDKQIVMWCINDYLGMSKHIKVMQASIDALLEYGVGSGGTRNIGGNNISILELEKELADLHSKETALVFTSGFVANDTTLASLAKIIPDIVFFSDELNHASIIAGITSSRAEKYVYRHLDVQHLEKLLQSVDINKPKIIVFESAYSMDGFFSPIKDIINLAKKYNALTFIDEVHTVGLYGKQGGGISELLDCSNQIDIIQGTLAKAYGTIGGYITSNYNLIDAIRLTAPGFIFTTSLPPVISTAATHSIRHLKVSNEERIKHQEVVTKLKNSFEHFNIPYLKNESHIIPIIIGDPIKATKVSNMLLNEYGIYVQHINFPTVPRGTERLRIIPTPAHTDKMINDLSTALVHIFAELDIELSSTKELNKEVRLHLIA
What are the official names of this protein?
5-aminolevulinate synthase, 5-aminolevulinic acid synthase, Delta-ALA synthase, Delta-aminolevulinate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: TMA16_MOUSE
Sequence: MPKGLKGKMVGREKKVIHPYSRKAAQITRESHKQDKKERLKTEKALRLNLIGDKLQWFHSHLDMKKTRYSKKDACELVERYLDRFSSELEQIELQNSIKDRQGRRHHSREAVIKQTLERERQQYEGYGFEIPDILDSNTLQTFREWDFDLKKLPNIKMRKLCADDAVPKKRKQKNILNIEKDLGELELSGPTGATTDGKLEPASESSDTDEEMTPVPVSPH
What is the function of this protein?
Involved in the biogenesis of the 60S ribosomal subunit in the nucleus.
What are the official names of this protein?
Translation machinery-associated protein 16.
What is the protein family that this protein belongs to?
Belongs to the TMA16 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FABH_CHLTE
Sequence: MKAAITTTAKYLPEEIMSNQDLERILDTNDEWITTRTGIKERRILRDPKKATSYMCTEVARQLLEKRGISADEIDLIIVATMSPDMLFPSTACLVQGNIQAKNAWGFDLSAACSGFVYGLYTGAQFIESGNCKKVMVIGADKMSSILDYEDRTTAILFGDGAGGVILEAANEEGYGVLDARLYSDGLNGREHLLMPGGGSLHPASHETVDQHMHFIQQDGKQVFKAAVIAMADVAEEIMQRNNLTAETIDWLVPHQANQRIIHATAERMGITEEKVMMNIARYGNTTAGTVPICLAELDEQGKLHKGSNLVLVSFGAGYTWGGVYVRWQ
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y370_LIGS1
Sequence: MMNISGPREGDFITIKSYKHDGSLHRTWRDTMVLKTSENALIGCNDHTLVTESDGRRWITREPALVYFHKHYWFNIVTMIRENGVSYYCNLASPAVLDKEALKYIDYDLDVKVFPNGEKRLLDVDEYEDHGNKWHYSADIDKILKHNVRVLVDWINNGKGPFSKEYVEIWYNRYLELSRQQ
What are the official names of this protein?
UPF0374 protein LSL_0370.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: RL15_DESAL
Sequence: MKLNELSPPKGARTARKRKGRGPGSGLGKTAGKGHKGQKARSGGGVRPGFEGGQMPVHRRLPKRGFCNIFAKKIAAVNVRDLARFEADSVVDAAALREARLISGKVDGVKILGHGEITQALTVKADQWSESAKEKIEKAGGKIEAA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GRCA_SALHS
Sequence: MITGIQITKAANDDLLNSFWLLDSEKGEARCIVAKSGFAEDEVVAVSKLGEIEYREIPMEVKPEVRVEGGQHLNVNVLRRETLEDAVKHPEKYPQLTIRVSGYAVRFNSLTPEQQRDVIARTFTESL
What is the function of this protein?
Acts as a radical domain for damaged PFL and possibly other radical proteins.
What are the official names of this protein?
Autonomous glycyl radical cofactor.
Protein: ALG8_GIBZE
Sequence: MSEHYPTLAQTALVAAAFKILLFPAYKSTDFEVHRNWLAITNSLPLEKWYVEKTSEWTLDYPPFFAYFEWILAHVARLVDPLMVKVYNLDYDSWQTVYFQRTSVIVTELVLVWALQTFIETAPLKSRRAAQTVALSIILSPGLLIIDHIHFQYNGFMYGILVMSLVLARQNSELLSSGLIFAALLCFKHIYLYLAPAYFVYLLRAYCLSSKSIFRIRFLNSIKLGLGIGAIFGAAFGPFAAMDQIPQLLSRLFPFSRGLCHAYWAPNVWALYSFADRILIHVAPRLGWAVNKSALQSVTRGLVGDTAFAVLPEISPRTCFVLTLFFQVVPLIKLFFQPTWETFIGAVTLCGYSSFLFGWHVHEKAILLVIIPFSLIALRDRRHLGAFRPLVVAGYVSLFPLLFTPAEFPIKTIYTIVWLVVFLLAFGRLAPASNKPRIFLLDRFSTLYIAISIPLILYCSLLHHLIFGKAYEFIPLMFTSSYTAIGVVGSWVGYMVVYFTA
What is the function of this protein?
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
What are the official names of this protein?
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 8, Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the ALG6/ALG8 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SSRP_AROAE
Sequence: MSIIDNRKAFHDYFIEETYEAGLVLEGWEVKAIRAGRANIKEAYVILRGEELFILGMHISALQSASTHVETDPVRTRKLLMHAKEIAKLIGKVERAGFTLVPLDLHYAKGRIKATIGLAKGKKQYDKRESEKERDWERDKARLMRVKT
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CHMU_MYCBO
Sequence: MRPEPPHHENAELAAMNLEMLESQPVPEIDTLREEIDRLDAEILALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLGH
What is the function of this protein?
Catalyzes the Claisen rearrangement of chorismate to prephenate.  Probably involved in the aromatic amino acid biosynthesis.
What are the official names of this protein?
Intracellular chorismate mutase, CM.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_PSEMY
Sequence: MLLLLAEYLQQFHKGFAVFQYLTLRGILGVLTALALSLWLGPWMIRTLQVRQIGQAVRNDGPQSHLSKKGTPTMGGALILTAIAVSTLLWADLSNRYVWVVLAVTLLFGAIGWVDDYRKVIEKNSRGLPSRWKYFWQSVFGLAAAIFLYMTAQSPVETTLILPLLKDVSIPLGIGFVVLTYFVIVGSSNAVNLTDGLDGLAILPTVMVAGALAVFCYLSGNVNFAEYLLIPYVPGAGELIVFCAALVGAGLGFLWFNTYPAQVFMGDVGALALGAALGTIAVIVRQEVVLFIMGGVFVMETLSVIIQVASFKLTGKRVFRMAPIHHHFELKGWPEPRVIVRFWIITVILVLIGLATLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL13_MOOTA
Sequence: MSTFMAKPHEVERKWYVIDAAGKTLGRVATEAARLLRGKHKPIFTPHVDTGDYVIIINAAKVRLTGNKLQKKQYIRHTGYPGGLRVMNYATLLRTFPERAVEKAVKGMIPHNSLGRKMVKKLKVYRGDSHPHAAQQPQVWEIKD
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: JZT36_CHIGU
Sequence: MKVSVLITLAVLGVMFVWASAAELEQSGSDQKDSDSPAWLKSMERIFQSEERDCRKMFGGCSKHEDCCAHLACKRTFNYCAWDGSFSK
What is the function of this protein?
Probable ion channel inhibitor.
What are the official names of this protein?
U13-theraphotoxin-Cg1a, U13-TRTX-Cg1a, Jingzhaotoxin-36, JZTX-36, Peptide F1-27.85.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 41 (Jztx-36) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYC_METBF
Sequence: MLQVYNTLTRKKEVFKPLKEGEVSIYACGPTVYNMPHIGNYRTFLMADNIVRSLEYLGYKVKLVMNITDIDDKTIRDSKAAGMSLKDFTDKYTAEFFKGLDMLNIKRASAYPRATENIDSMIELTQKLIDKGMAYEKGGSVYYRISSFPDYGKLSKLDFDSIIIGASVDVDEYDKDNPRDFALLKTSTPEEIERGIYYESPWGKIRPGWHIECSVMAMNCFGPTLDMHLGGVDLIFPHHENEIAQSEGATGKPFACYWIHGEHLIVEGEKMSKSKGNVFTLPEIVGKYGGEVVRFMFLSVHYRKKLDYSDAFAENAKNNYLRLKETLENLEFSLESAENTDYPGDEEVLKILPELETQFREALEDDFNIPKALTVFKELSRTANKYLESEKNRHVLEKLYSLYRQFSDTLGLFSESGKKEIPTEVMRLVEEREAARKKKDWTVSDAIREKIKSLGYIVQDTKEGPNVKETE
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_DESOH
Sequence: MAVVDIKNMNGETVSQAELPDSIFDVEVKSSVLHEVVKMQLARRRSGTASTKGRSDVAGSRAKLFRQKGTGRARRGDVKSPLLKGGGVVFGPHPRSFDYSVPKKVRKLALKMALTSKLRDNTLTVVDQFRFDRIKTKDFVGAINALGAANALVISDGSETLEKSARNVPKVKVLKCEGLNVYDILKYKNLVLPEAAIKMIEGRLL
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: TILS_METNO
Sequence: MTEAARPLDREEFARRLDRWLGPGAAGGVVLAVSGGPDSTALMGGAARLPPLVPVMVATVDHGLRPEAAAEAEAVARLAGRLGLPHRILAWTGPKPRTRLQEAARAARYRLLLDLAREQGAAALLTAHTLDDQAETVLMRLCAGSGPAGLGGIEPVRHLGGLALVRPFLDLPKARLVATCAAEGWPFVVDPGNADARFARGRLRRVMPHLAAEGLTAARLARLAERLRRNEAALAAAADAALDALARPGARPGGMMLDARGLAVLPEAVALRVLARAIATVVGGNARPARLERLEDVLFGRLLPAIAAGGRLRCTLGGALLHLSGGSLSLSPEPPRRAG
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMEN_DROVI
Sequence: MALEDRCSPQSAPSPPGCLPHSPPQQHQHILQPNLRIHAIPISITALDMSLQPGTAATAATLYQQQQLQHLHQLQQLQQLHQQQLAASAGVFHHPSTSAAFDAAALHAAALQQRLSASGSPGAHSTGACSTPASTLTIKEEESDSILGDSFHNQTATTATEEDEEEDDDIDVDDTASVSGSARLPPPAHQQSKQSKPSLAFSISNILSDRFGDAAKQTKQGDSTGVSVSAAAAAASIFRPFEASRAAAATPSAFTRVDLLEFSRQQQAAAAAATAAMMLERANLLNCFNPAAYPRIHEELVQSRLRRSAAGNPNAVLPPTAKLTEPSVEKSALGSLCKTVSQIGQAQSTTPVTTPSSRPSQLASPPPASNASTISSSSSTAASCSASSSSGCSSAASSLNSSPSSRLAGANNASSPQPIPPPSAVSRDSGMESSDDTRSETGSTTTDGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEEELEMRMNGQIP
What is the function of this protein?
This protein specifies the body segmentation pattern.  It is required for the development of the central nervous system.  Transcriptional regulator that repress activated promoters.
What are the official names of this protein?
Segmentation polarity homeobox protein engrailed.
What is the protein family that this protein belongs to?
Belongs to the engrailed homeobox family.
What are the subcellular locations of this protein?
Nucleus.