PharMolix/UniProtQA huggingface dataset:
Protein: SPED_SALPC
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPKLIDQTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGMKHFIDHEINSIQNFMSEDMKSLYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTETERQEITAALWKEMREIYYGRNISAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: RUVB_CALBD
Sequence: MERLLDNKFSIEDVHEESLRPKTLEEYIGQQKVKEKIKIFIEAAKKRKEPLDHVLLYGPPGLGKTTLANIIANEMGVDIKITSGPAIERAGDLVAILTNIGENNILFIDEIHRLNRTIEEVLYPAMEDKKVDIVIGKGPSAKTIRLTLPPFTLIGATTRAGLLSSPLRDRFGIIERLDYYTVEELSQIVMRSASILKCDIEKEACIEIAKRSRGTPRVANRLLRRLRDYAMVKHTGSITYEVAKSGLEMFEVDEYGLDLVDRNILEAIVYKFGGGPVGLSTIAAAISEDEGTIEDIYEPYLIQEGFLVKTARGRVATQKAISHIAKIKFKLKESGDNR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CH10_HELPJ
Sequence: MKFQPLGERVLVERLEEENKTSSGIIIPDNAKEKPLMGVVKAVSHKISEGCKCVKEGDVIAFGKYKGAEIVLDGTEYMVLELEDILGIVGSGSCCHTGNHDHKHAKEHEACCHDHKKH
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FYCO1_HUMAN
Sequence: MASTNAESQLQRIIRDLQDAVTELSKEFQEAGEPITDDSTSLHKFSYKLEYLLQFDQKEKATLLGNKKDYWDYFCACLAKVKGANDGIRFVKSISELRTSLGKGRAFIRYSLVHQRLADTLQQCFMNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNYVLSKHGGKKERCCRACFQKLSEGPGSPDSSGSGTSQGEPSPALSPASPGPQATGGQGANTDYRPPDDAVFDIITDEELCQIQESGSSLPETPTETDSLDPNAAEQDTTSTSLTPEDTEDMPVGQDSEICLLKSGELMIKVPLTVDEIASFGEGSRELFVRSSTYSLIPITVAEAGLTISWVFSSDPKSISFSVVFQEAEDTPLDQCKVLIPTTRCNSHKENIQGQLKVRTPGIYMLIFDNTFSRFVSKKVFYHLTVDRPVIYDGSDFL
What is the function of this protein?
May mediate microtubule plus end-directed vesicle transport.
What are the official names of this protein?
FYVE and coiled-coil domain-containing protein 1, Zinc finger FYVE domain-containing protein 7.
Protein: SHSA8_MOUSE
Sequence: MERAGARGQRCGRRSHGLPLALRLALLLAGSPSGRAGAPEEQEIAGSGTVAPAGGDRCRGYYDVMGQWDPPFNCSSGVYSFCCGTCGYRFCCHDGPRRLDQSRCSNYDTPAWVQTGRPPARARDTAAPRDPARERSHTAVYAVCGVAALLVLVGIGARLGLERAHSPRARRTVTRTLTELLKQPGPQEPLPPPLGPPLGNCVQVQMGDGVLRGSPHNSTDKKRLNNAPLGSATPGPPRGPRLQGGGSLTLQPDYAKFATLKAAALKATEVAPQDFYQRFPSTETGPRTLPARVPRPPEDLPALLDACPWAPPGYVPPAGPVSSVPYAAWTAGRPARPLPRSHLVAQVSPAPRRPNHAPRRQFSVEKLPEAFSAQQASFYSSAGRGPRHLSTNSKAEVTV
What is the function of this protein?
May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.
What are the official names of this protein?
Protein shisa-8, Cystine-knot AMPAR modulating protein of 39 kDa, CKAMP39, Shisa family member 8.
What is the protein family that this protein belongs to?
Belongs to the shisa family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL11_ACICJ
Sequence: MAKKVVGYIKLQIPAGKANPSPPVGPALGQRGLNIMQFCKDFNAATQGMEVGMPVPVVITAYADRTFSFITKTPPNTYFLKKAAGIQKGSTATGKGATVGKVTMSQLREIAQTKMVHMNANDVDGAVRMLVGSARSMGLSVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CA2D3_RAT
Sequence: MAGPGSLCCASRGASALLATALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNVLSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPERKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLADDQGLVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGAPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKARDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGTVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIVTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPEENARECGGASSLQAQVALLLLPLVSSLFSR
What is the function of this protein?
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.  Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).
What are the official names of this protein?
Voltage-dependent calcium channel subunit alpha-2/delta-3, Voltage-gated calcium channel subunit alpha-2/delta-3.
What is the protein family that this protein belongs to?
Belongs to the calcium channel subunit alpha-2/delta family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GCSPA_CHLT3
Sequence: MPFIPNTDADRATMLQAVGASTFDDLISNIPEKVRFKGALNLPEALSEMEVLEELNALANANQDTQKVTSFLGGGAYDHFVPSAIGAIISRSEFYTAYTPYQAEVSQGTLQAMYEFQTMVARLTGMDVANASMYDGATALAEAMLLSVAHKNRKEVVLAGKINPNAVAIMQTYGHGQEIHIRQSALENGGADLASVRELVSDKTAAMIVQHPNFFGCLEDVHELQKIAAENNALFIVSADPISLGILEAPGNYGADIVVGEGQGLGNTQSFGGPYLGLFAAKSQLLRKIPGRLSGMTVDKDGNQGFILTLQTREQHIRREKATSNICTNQALNALCACIYMSMMGKEGLTQVASLSIQKAHYLANEIQKLDGFKLKFSRPFFKEFAIELPIPASQAIAKLLEKKIHAGVDLKMAEENGLLIAVTEKRSKAEMNSFVEALKELC
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: EF1A_HELVI
Sequence: HVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSTEPPYSESRFEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEASTKMPWFKGWNVERKEGKAEGKCLIEALDAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGILKPGTIVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKNNPPKGAADFTAQVIVLNHPGQISNGYTPVLDCHTAHIACKFAEIKEKVDRRTGKSTEDNPKSIKSGDAAIVNLVPSKPLCVESFQEFPPLGRFAVR
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor 1-alpha, EF-1-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1901_PSEPK
Sequence: MDTKLLDILACPITKGPLKLSADKTELISKGAGLAYPIRDGIPVMLESEARTLTDDERLDK
What are the official names of this protein?
UPF0434 protein PP_1901.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: TIGA_ASPNG
Sequence: MVRLSNLVSCLGLASAVTAAVVDLVPKNFDDVVLKSGKPALVEFFAPWCGHCKNLAPVYEELGQAFAHASDKVTVGKVDADEHRDLGRKFGVQGFPTLKWFDGKSDEPEDYKGGRDLESLSSFISEKTGVKPRGPKKEPSKVEMLNDATFKGAVGGDNDVLVAFTAPWCGHCKNLAPTWEALANDFVLEPNVVIAKVDADAENGKATAREQGVSGYPTIKFFPKGSTESVPYEGARSEQAFIDFLNEKTGTHRTVGGGLDTKAGTIASLDELIASTSAADLAAAVKKAATELKDKYAQYYVKVADKLSQNAEYAAKELARLEKILAKGGSAPEKVDDLISRSNILRKFVGEEKEAKDEL
What are the official names of this protein?
Protein disulfide-isomerase tigA.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: HISX_RHORT
Sequence: MPLRLEASSADFAPAFAALLAGKRESAQDVNDVVSAILADVRLRGDDALIDYTARFDKMTVSAEGLRFSDDEVDTAVALIEPALRDALALAAKRITRFHERQMPTAISFTDEDGVRLGQRWTAVSAAGLYVPGGLAAYPSSVLMNALPAKVAGVERLVMVVPTPAGRINPLVLAAAKLAGVDEIYRVGGAQAVAALAYGTRTIAPVDKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEILVVADGANDPDWIALDLLSQAEHDAAAQSILITDDRAFADRVERAVTDRLRTLSRTEIASASWRDHGAIILVGDLLRDAPALVDKVAPEHLELAVADPDALAARVRHAGAIFLGRYTPEAIGDYIAGPNHVLPTSRTARFSSGLGVLDFMKRTTLVGCGAESLGAIGPSAVRLARAEGLEAHGLSVAARMNRGWE
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: BGAL_KLULA
Sequence: MSCLIPENLRNPKKVHENRLPTRAYYYDQDIFESLNGPWAFALFDAPLDAPDAKNLDWETAKKWSTISVPSHWELQEDWKYGKPIYTNVQYPIPIDIPNPPTVNPTGVYARTFELDSKSIESFEHRLRFEGVDNCYELYVNGQYVGFNKGSRNGAEFDIQKYVSEGENLVVVKVFKWSDSTYIEDQDQWWLSGIYRDVSLLKLPKKAHIEDVRVTTTFVDSQYQDAELSVKVDVQGSSYDHINFTLYEPEDGSKVYDASSLLNEENGNTTFSTKEFISFSTKKNEETAFKINVKAPEHWTAENPTLYKYQLDLIGSDGSVIQSIKHHVGFRQVELKDGNITVNGKDILFRGVNRHDHHPRFGRAVPLDFVVRDLILMKKFNINAVRNSHYPNHPKVYDLFDKLGFWVIDEADLETHGVQEPFNRHTNLEAEYPDTKNKLYDVNAHYLSDNPEYEVAYLDRASQLVLRDVNHPSIIIWSLGNEACYGRNHKAMYKLIKQLDPTRLVHYEGDLNALSADIFSFMYPTFEIMERWRKNHTDENGKFEKPLILCEYGHAMGNGPGSLKEYQELFYKEKFYQGGFIWEWANHGIEFEDVSTADGKLHKAYAYGGDFKEEVHDGVFIMDGLCNSEHNPTPGLVEYKKVIEPVHIKIAHGSVTITNKHDFITTDHLLFIDKDTGKTIDVPSLKPEESVTIPSDTTYVVAVLKDDAGVLKAGHEIAWGQAELPLKVPDFVTETAEKAAKINDGKRYVSVESSGLHFILDKLLGKIESLKVKGKEISSKFEGSSITFWRPPTNNDEPRDFKNWKKYNIDLMKQNIHGVSVEKGSNGSLAVVTVNSRISPVVFYYGFETVQKYTIFANKINLNTSMKLTGEYQPPDFPRVGYEFWLGDSYESFEWLGRGPGESYPDKKESQRFGLYDSKDVEEFVYDYPQENGNHTDTHFLNIKFEGAGKLSIFQKEKPFNFKISDEYGVDEAAHACDVKRYGRHYLRLDHAIHGVGSEACGPAVLDQYRLKAQDFNFEFDLAFE
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: RK32_BRACM
Sequence: MAVPKKRTSISKKRIRKKIWKRKGYWTSLKAFSLGKSLSTGNSKSFFVQQNK
What are the official names of this protein?
50S ribosomal protein L32, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TARK_BACSH
Sequence: MKTFLTRIVKGVFGTAYKLLSALLPVQHDKVVIASYREDQLSDNFRGVYEKLKQDPSLRITLLFRKMDKGLIGRAAYLLHLFCSLYHLATCRVLLLDDYYFPLYVVPKRKETVAIQLWHACGAFKKFGYSIVNKPFGPSSDYLKIVPVHSNYDYAIVSAPAAVPHFAEAFQMEEKQILPLGIPRTDYFYHKEHIRTVLDEFHQAYPELKHKKKLLYAPTFRGSGHHQEGDATPLDLLQLKSALHHKDYVVMLHLHPYMRKHAHTEEDDFVLDLTDSYSLYDLMAISDGLITDYSSVIFEYSLLKRPMYFYCPDLEDYLKERDFYYPFESFVPGPISKDVPSLVHDIESDHEADTKRIEAFSQTYITHQDGKSSERVADFISSFLTSGAD
What is the function of this protein?
Catalyzes the addition of a single ribitol phosphate unit onto the glycerol phosphate of the linkage unit, as a primer for polymerisation by TarL.
What are the official names of this protein?
Teichoic acid ribitol-phosphate primase, Tar primase.
What is the protein family that this protein belongs to?
Belongs to the CDP-glycerol glycerophosphotransferase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ACDH2_RHOOB
Sequence: MSRKSAAIIGSGNIGTDLMYKLLRSEHIEPRYMVGIDPDSEGLARARQEGLEASAGGLDWLLAQPELPDFVFEATSAKIHAAAAPRYADAGITAIDLTPASVGPYVVPAVNLDAHLGAPNVNMVSCAGQATIPILYAINEVADASYGEIVAAIASHSAGPGTRQNLSEFSEKTGKALAQVAGADRAKAISVINPAEPPMNMRDTVYAKVRNPDPAAIEKAVIDMVAKVQQYVPGYSLRLVDVDGDLVTVMLEVVGAGDFLPTYAGNLDIITAAAVQVADVMAQQNLVQGAAQ
What are the official names of this protein?
Acetaldehyde dehydrogenase 2, Acetaldehyde dehydrogenase [acetylating] 2.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: CIP1_MOUSE
Sequence: MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLDIVRTELSPSEEYKAMVLAGLRPEVVLDISSRALAFWTYQVHQERLYQEYNFSKAENHLKQMEKMYMQQIQSKNIELTSMKGEVISMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIASQEGSLEPGMIPQSGVFGFPPGNNSKFSLDHIPVGNQGGGDEDVQFRPFFVCSPTAPEPINNFFSFASPSHEAEQQVCSRAFKAKRI
What is the function of this protein?
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites.  Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites.  Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over.  Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase.  Overexpression causes delayed entry into mitosis.
What are the official names of this protein?
E3 ubiquitin-protein ligase CCNB1IP1, Cyclin-B1-interacting protein 1, RING-type E3 ubiquitin transferase CCNB1IP1.
Protein: ANFC_LITCT
Sequence: MSYKRGTCLGFIMLLMVSHHHTKGKPLSSLQNLSRLLEDNFERSFGSDEADQQLVPTDSLDQLDPELQWNKNRLEQGDSPHVNEMTLQQLLNDPVGTSRRYRQRNKKGYSRGCFGVKLDRIGAFSGLGC
What is the function of this protein?
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation.  May also be vasoactive and natriuretic.  May be important for freshwater adaptation (By similarity).
What are the official names of this protein?
C-type natriuretic peptide 1, CNP I.
What is the protein family that this protein belongs to?
Belongs to the natriuretic peptide family.
What are the subcellular locations of this protein?
Secreted.
Protein: LOLD_ALIF1
Sequence: MSNPLLVCQGIRKVYQEGAMETEVLKGVDFQINGSELVAIVGSSGSGKSTLLHILGALDEPTAGTVHFQENELTKLSANKQAKIRNQHIGFVYQFHHLLADFSALENVAMPLLIGGVNKKEAAKRATELLEKVGLAHRIEHRPSELSGGERQRVAIARALVNKPALVLADEPTGNLDHKTALDIYNLMRELNQESGTAFLVVTHDNELAAKLDKQLSMQDGRFITETVRSSLAQEMEA
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DUT_HCMVA
Sequence: MLTMLTDRIDSQLVLSRLPRSRFQRFWETPTLIMKEESASSSGSIILAEKSVNMRYCVRFASDSDFQTTFTLPQSTEEKYDKEQHPGEDEASSPLPSPLKVPYKWMPSSFIVKQCHTQLAFYNKHIIWLSRERKVPTSLGVSLYIPEGFFGITFYKCLDAQFVCMPELLESRLQVPQLDVVNLNDTFQSIFPGTIEGDIGVFPCFVPEPWQLMNLPPPNEHRFFSLRTRQTLVIGPGHTQTVYFDAAYVHAPGICALIVGVRQFSQSDLIIRPTIWLPGTAAGVTVVNTSHTTVCISPHTTVAKAVFTTHRFTYLPVGSHPLGQMIVPPTPDIGFTHTPEHALLQRTPSPVDDDVDETEEDEKSSDAESPVNTNDVIFDVGPKPPRHP
What is the function of this protein?
Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
What are the subcellular locations of this protein?
Virion.
Protein: RSXC_ECOSM
Sequence: MLKLFSAFRKNKIWDFNGGIHPPEMKTQSNGTPLRQVPLAQRFVIPLKQHIGAEGELCVSVGDKVLRGQPLTRGRGKMLPVHAPTSGTVTAIAPHSTAHPSALAELSVIIDADGEDCWIPRDGWDDYRSRSREELIERIHQFGVAGLGGAGFPTGVKLQGGGDKIETLIINAAECEPYITADDRLMQDCAAQVVEGIRILAHILQPREILIGIEDNKPQAISMLRAVLADSHDISLRVIPTKYPSGGAKQLTYILTGKQVPHGGRSSDIGVLMQNVGTAYAVKRAVIDGEPITERVVTLTGEAIARPGNVWARLGTPVRHLLNDAGFCPSADQMVIMGGPLMGFTLPWLDVPVVKITNCLLAPSANELGEPQEEQNCIRCSACADACPADLLPQQLYWFSKGQQHDKATTHNIADCIECGACAWVCPSNIPLVQYFRQEKAEIAAIRQEEKRAAEAKARFEARQARLEREKAARLERHKSAAVQPAAKDKDAIAAALARVKEKQAQATQPIVIKAGERPDNSAIIAAREARKAQARAKQAELQQTNDAATVADPRKTAVEAAIARAKARKLEQQQANAEPEQQVDPRKAAVEAAIARAKARKLEQQQANAEPEQQVDPRKAAVEAAIARAKARKLEQQQANAEPEEQVDPRKAAVAAAIARVQAKKAAQQKVVNED
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rsx electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GMHA_LARHH
Sequence: MELIERVNGHFLESMAAKQLAMEVLPGTIAQAAESMVACLMNEGKILACGNGGSAADAQHFAAEMVGRFEKERPGLAALSLATDTSALTAIGNDYDFERVFSKQVRALGQDGDLLLALSTSGNSLNVIEAIHAAHERQMGVIALTGRDGGQIADLMTADDILINVPVERTARIQEVHITIIHALCDAVDYMLLGGD
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: I1B1_CONBE
Sequence: MKLCVAFLLVLVILPSVIGGKPSERTLSGATRRGDRRMCLSLGQRCERHSNCCGYLCCFYDKCVVTAIGCGHY
What are the official names of this protein?
Conotoxin Bt11.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin I1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DOT1_NEUCR
Sequence: MSIFNQKSKFKIKTEIRTVRETVERPKLKASTSSSSIPTTGSSQHSNVRIAGAGSSLSRASSTPRLNGTSHTTSTSSSARASLTKVTTIPTARRIQSASPIPSINGDGRSSRKRRAIKASSRSPISPHFSEDSDSDSNGDENWEDNLDARKRRKRVHDERPVDVNRKLRHPKIWKGEEADQVERIPGPAIIHAAKVASLEHKCKPALGLKNEEVAVRLQYPGARYPERYELVEGKDKIDAVKDIEKVVQLAASTYLTDEEGKIFLDHQTGILRKLVKSKNRSDGPGFKAALREYNDEFLKLMRKGVIVRNLDKMHGIPRELVDFILDQVYDRTVAPRVELLAKYQNGSDNVYGELNHPFISDILERTNLTSDKVFVDLGSGVGNVTLQAALEIGCESWGCEMMENACNLAEAQYDEFLARCRLWGVKPGKVRLERGDFRKNEKILEVLKRADVVLVNNQAFTSQLNDNLVSMFLDLKIGCKIISLKTFVHDNKNAENDVATSILDVEHLTYPEGYVSWTGASGTYCISTRR
What is the function of this protein?
Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3.  This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks.  Nucleosomes are preferred as substrate compared to free histone.
What are the official names of this protein?
Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone H3-K79 methyltransferase, H3-K79-HMTase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: END8_ECO27
Sequence: MPEGPEIRRAADNLEAAIKGKPLTDVWFAFPQLKSYQSRLIGQHVTHVETRGKALLTHFSNDLTLYSHNQLYGVWRVVDTGEEPQTTRVLRVKLQTADKTILLYSASDIEMLTPEQLTTHPFLQRVGHDVLDPNLTPEVVKERLLSPRFRNRQFAGLLLDQAFLAGLGNYLRVEILWQVGLTGNHKAKDLNAAQLDALAHALLDIPRLSYATRGQVDENKYHGALFRFKVFHRDGEPCERCGGIIEKTTLSSRPFYWCPGCQH
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Endonuclease 8, DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: CDH_ECODH
Sequence: MKKAGLLFLVMIVIAVVAAGIGYWKLTGEESDTLRKIVLEECLPNQQQNQNPSPCAEVKPNAGYVVLKDLNGPLQYLLMPTYRINGTESPLLTDPSTPNFFWLAWQARDFMSKKYGQPVPDRAVSLAINSRTGRTQNHFHIHISCIRPDVRKQLDNNLANISSRWLPLPGGLRGHEYLARRVTESELVQRSPFMMLAEEVPEAREHMGRYGLAMVRQSDNSFVLLATQRNLLTLNRASAEEIQDHQCEILR
What are the official names of this protein?
CDP-diacylglycerol pyrophosphatase, CDP-diacylglycerol phosphatidylhydrolase, CDP-diglyceride hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Cdh family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.