PharMolix/UniProtQA huggingface dataset:
Protein: IACA_ACIB2
Sequence: MMNKLSKMEFAAQDKAVDLDALCQEIRERACAGEFDNQAYVSQDIIEKLKKIGVYRALVPKRFGGEEWSPRQFCELIETLSKADGSVGWVASFGMSPAYLGSLPEETLKELYQNGPDVVFAGGIFPPQPAEITDEGVVVRGRWKFSSGCMGADIVGVGISPLKNNEMQGLPRMAVMPANKAKIEMTWDTVGLKGTGSHDLVVEDVLVEKKWTFVRGEPSKLSEPFFKYPSLSLATQVLTVVGIGVAAAALEEFEKLAPGKASITGGSEIANRPVTQYEFAQADAEFQAAKSWFYQTMDIVWNEIIAGREATAEQISDMRLACTHAARVCAKVTRKMQMLAGMTAIYTNNPFSRFVNDTNVVTQHAFMGDATLQNAGLVSFGLKPAPGYL
What is the function of this protein?
Involved in the degradation of the plant hormone indole-3-acetic acid (IAA) (PubMed:22311185).  Catalyzes the first step of the pathway, the conversion of IAA to 2-hydroxy-IAA (2-OH-IAA) (By similarity).  Can also convert indole to indoxyl, which spontaneously dimerizes in the presence of oxygen to form the blue pigment indigo (PubMed:22311185).
What are the official names of this protein?
Indole-3-acetate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the HpaH/HsaA monooxygenase family.
Protein: DCUP_BURMS
Sequence: MAQTLLNDTFLRALLREPTDYTPIWLMRQAGRYLPEYNATRARAGSFLGLAKQPDYATEVTLQPLERFPLDAAILFSDILTIPDAMGLGLDFAAGEGPKFAHPVRTEADVAKLAVPDIGATLGYVTDAVREIRRALTDGEGRQRVPLIGFSGSPWTLACYMVEGGGSDDFRTVKSMAYARPDLMHRILDVNAQAVAAYLNAQIEAGAQAVMIFDTWGGALADGGYQRFSLDYVRRVLAQLKREHDGARVPAIAFTKGGGLWLEELAATGVDAVGLDWTVNLGRARERVAGRVALQGNLDPTILFAPPEAIRAEARAVLDSYGNHPGHVFNLGHGISQFTPPEHVAELVDEVHRHSRAIRSGAGS
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GTFB_STRMU
Sequence: MDKKVRYKLRKVKKRWVTVSVASAVMTLTTLSGGLVKADSNESKSQISNDSNTSVVTANEESNVTTEVTSKQEAASSQTNHTVTTISSSTSVVNPKEVVSNPYTVGETASNGEKLQNQTTTVDKTSEAAANNISKQTTEADTDVIDDSNAANLQILEKLPNVKEIDGKYYYYDNNGKVRTNFTLIADGKILHFDETGAYTDTSIDTVNKDIVTTRSNLYKKYNQVYDRSAQSFEHVDHYLTAESWYRPKYILKDGKTWTQSTEKDFRPLLMTWWPSQETQRQYVNYMNAQLGINKTYDDTSNQLQLNIAAATIQAKIEAKITTLKNTDWLRQTISAFVKTQSAWNSDSEKPFDDHLQNGAVLYDNEGKLTPYANSNYRILNRTPTNQTGKKDPRYTADNTIGGYEFLLANDVDNSNPVVQAEQLNWLHFLMNFGNIYANDPDANFDSIRVDAVDNVDADLLQIAGDYLKAAKGIHKNDKAANDHLSILEAWSDNDTPYLHDDGDNMINMDNKLRLSLLFSLAKPLNQRSGMNPLITNSLVNRTDDNAETAAVPSYSFIRAHDSEVQDLIRDIIKAEINPNVVGYSFTMEEIKKAFEIYNKDLLATEKKYTHYNTALSYALLLTNKSSVPRVYYGDMFTDDGQYMAHKTINYEAIETLLKARIKYVSGGQAMRNQQVGNSEIITSVRYGKGALKATDTGDRTTRTSGVAVIEGNNPSLRLKASDRVVVNMGAAHKNQAYRPLLLTTDNGIKAYHSDQEAAGLVRYTNDRGELIFTAADIKGYANPQVSGYLGVWVPVGAAADQDVRVAASTAPSTDGKSVHQNAALDSRVMFEGFSNFQAFATKKEEYTNVVIAKNVDKFAEWGVTDFEMAPQYVSSTDGSFLDSVIQNGYAFTDRYDLGISKPNKYGTADDLVKAIKALHSKGIKVMADWVPDQMYAFPEKEVVTATRVDKFGKPVEGSQIKSVLYVADSKSSGKDQQAKYGGAFLEELQAKYPELFARKQISTGVPMDPSVKIKQWSAKYFNGTNILGRGAGYVLKDQATNTYFNISDNKEINFLPKTLLNQDSQVGFSYDGKGYVYYSTSGYQAKNTFISEGDKWYYFDNNGYMVTGAQSINGVNYYFLSNGLQLRDAILKNEDGTYAYYGNDGRRYENGYYQFMSGVWRHFNNGEMSVGLTVIDGQVQYFDEMGYQAKGKFVTTADGKIRYFDKQSGNMYRNRFIENEEGKWLYLGEDGAAVTGSQTINGQHLYFRANGVQVKGEFVTDRYGRISYYDSNSGDQIRNRFVRNAQGQWFYFDNNGYAVTGARTINGQHLYFRANGVQVKGEFVTDRHGRISYYDGNSGDQIRNRFVRNAQGQWFYFDNNGYAVTGARTINGQHLYFRANGVQVKGEFVTDRYGRISYYDSNSGDQIRNRFVRNAQGQWFYFDNNGYAVTGARTINGQHLYFRANGVQVKGEFVTDRYGRISYYDANSGERVRIN
What is the function of this protein?
Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris.
What are the official names of this protein?
Glucosyltransferase-I, GTF-I, Dextransucrase, Sucrose 6-glucosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 70 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACYP_VIBCH
Sequence: MEKQCSKFIVSGHVQGVGFRYHTSHQGLKLGLTGYAKNLNNGDVEVVACGTPERLEELYLWLQEGPKTASVRQVRRLSSELEHDYQGFEIL
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: DEOB_BACC0
Sequence: MNKYKRIFLVVMDSVGIGEAPDAEQFGDLGSDTIGHIAEHMNGLHMPNMVKLGLGNIREMKGISKVEKPLGYYTKMQEKSTGKDTMTGHWEIMGLYIDTPFQVFPEGFPKELLDELEEKTGRKIIGNKPASGTEILDELGQEQMETGSLIVYTSADSVLQIAAHEEVVPLDELYKICKIARELTLDEKYMVGRVIARPFVGEPGNFTRTPNRHDYALKPFGRTVMNELKDSDYDVIAIGKISDIYDGEGVTESLRTKSNMDGMDKLVDTLNMDFTGLSFLNLVDFDALFGHRRDPQGYGEALQEYDARLPEVFEKLKEDDLLLITADHGNDPVHHGTDHTREYVPLLAYSPSMKEGGQELPLRQTFADIGATVAENFGVKMPEYGTSFLNELKK
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THII_ECO7I
Sequence: MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTEQEVVEVETVNGFGPNDVILDIRSIDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQSKTWLLWCERGVMSRLQALYLREQGFNNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFCS1_MIMIV
Sequence: MTNSIPWIEKYRPVNIDDVIIDDNISKQINIFLQDRENVHLIITGSPGVGKTSTVRCIAKELLGEDMSQGYLEINAAEDRGVRSISTIIPPFCKKVFAANKSKIILLDEADIMTSKCQYDINNMIKKFGRKTKFIFTCNDSSKIIEDIQSICRILRFKKLTDEQINQYLSKICVNEKIPYDEQGLRTICYISNGDMRKSINDLQKTAFTFEKITKNLVLKICKVPDPEDIRKIISLCLESNLEKADEIMNNIIKLDYCYFDIVTSFIYVLKVYDMSENLRLRLIMIVNETKINISKGLRSKLQLTGMICRLIKEIQRDE
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Putative replication factor C small subunit R395, RFC small subunit R395, Clamp loader small subunit R395.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: BIOF_KLEP7
Sequence: MSWQQRIDRALDERRAAEAFRRRLPVTHGAGRWLEREGERWLNFSSNDYLGLSQHPAIIAAWQQGATRYGVGAGGSGHVSGYSEAHRALEEALADWLGYPRALLFISGFAANQALIAALAEKDDRIVADRLSHASLLEAASLSPAQLRRFTHNDPQQLAQLLAKPLAGEQLAVTEGIFSMDGDSAPLAAIHAATQAAGAVLLVDDAHGVGVIGDEGRGSCAAQAVRPELLVVTFGKAFGVSGAAVLCDEAMADYLLQFARHLIYSTAMPPAQAVALSAALRIIRSDEGQQRRDILAARIRQFREGMGEVSLGLTDSVSAIQPLIVGDNARALNLACRLRDAGCWATAIRPPTVPVGSARLRLTLTAAHHTEDINRLLEVLHGHSE
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: EFTS_GEOTN
Sequence: MAITAQMVKELREKTGAGMMDCKKALTETNGDMEKAIDWLREKGIAKAAKKADRIAAEGMTYIATEGNAAVILEVNSETDFVAKNEAFQTLVKELAAHLLKQKPATLDEALGQTMSSGSTVQDYINEAVAKIGEKITLRRFAVVNKADDETFGAYLHMGGRIGVLTLLAGSATEEVAKDVAMHIAALHPKYVSRDEVPQEEIAREREVLKQQALNEGKPENIVEKMVEGRLKKFYEDVCLLEQAFVKNPDVTVRQYVESSGATVKQFIRYEVGEGLEKRQDNFAEEVMSQVRKQ
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XKDT_BACSU
Sequence: MFEDQTFEAIMERMLNSISADIDTREGSVIYNALAPAAAELAKSYIWLDTVLELVFSDTAQGEFLDRRAAEAGIERTAATKAVRAGEFTSGVTIPVGSRFYVDNLYFQYTADGTLICETPGEAGNANLTGRNLLSLDTIPGLETAIVKEILIPGREEEGDDSLRERYFTRVRREAVSANKMHYKEWAEEVDGVGKAKIFPLWNGEGTVKIVVTNANLEPASPILIQKVKDYIDPEPGQGEGQAPIGAVVTVESAVWKEVEISAEVLPEINHSIDEVKSEIEEGVLNFFKKMAFEDNVIRLSQINNIVYNSPSVSDYSNIQINGTSENLVLSDVEIPKLGQVKIIEQTR
What are the official names of this protein?
Phage-like element PBSX protein XkdT.
What is the protein family that this protein belongs to?
Belongs to the Mu gp47/PBSX XkdT family.
Protein: SAUSY_SANAS
Sequence: MDSSTATAMTAPFIDPTDHVNLKTDTDASENRRMGNYKPSIWNYDFLQSLATHHNIVEERHLKLAEKLKGQVKFMFGAPMEPLAKLELVDVVQRLGLNHRFETEIKEALFSIYKDESNGWWFGHLHATSLRFRLLRQCGLFIPQDVFKTFQNKTGEFDMKLCDNVKGLLSLYEASYLGWKGENILDEAKAFATKYLKSAWENISEKWLAKRVKHALALPLHWRVPRIEARWFIEAYEQEANMNPTLLKLAKLDFNMVQSIHQKEIGELARWWVTTGLDKLAFARNNLLQSYMWSCAIASDPKFKLARETIVEIGSVLTVVDDAYDVYGSMDELDLYTSSVERWSCVEIDKLPNTLKLIFMSMFNKTNEVGLRVQHERGYNSIPTFIKAWVQQCKSYQKEARWFHGGHTPPLEEYSLNGLVSIGFPLLLITGYVAIAENEAALDKVHPLPDLLHYSSLLSRLINDIGTSPDEMARGDNLKSIHCYMNGTGASEEVAREHIKGVIEENWKILNQCCFDQSQFQEPFITFNLNSVRGSHFFYEFGDGFGVTDSWTKVDMKSVLIDPIPLGEE
What is the function of this protein?
Catalyzes a mixture of sesquiterpenoids from (2E,6E)-farnesyl diphosphate in fragrance biosynthesis.  Catalyzes the formation of alpha-santalene, beta-santalene, epi-beta-santalene and exo-alpha-bergamotene, as well as traces of alpha-farnesene and beta-farnesene.
What are the official names of this protein?
Santalene synthase, SauSSy, Alpha-santalene synthase, Beta-santalene synthase, Exo-alpha-bergamotene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
Protein: LEPA_LACH4
Sequence: MDLEKLKDYQKHIRNFAIVAHIDHGKSTIADRILELTDTVSQRQLKNQMLDDMPLERQRGITIKMNSVEVKYHARDGEDYIFHLIDTPGHVDFSYEVSRSLAACEGALMVVDASQGVQAQTLANTYVAIDDDLEILPVINKIDLPSADIPKTKEEIEEMLGLDASEAAEVSGKTGQGIEDMLEKVVKDIPAPSGDITAPLKALIFDSKYDDYRGVVMSVKIEDGVVKPGDRIKIMNTGKEYEVTEVGVSSPHPVKKDLLIAGDVGYITANIKSVRETRVGDTITDATNPTEEPLEGYRQIPPMVYSGMYPVDNRDYDDLKEALQKLQLNDAALEFEPETSTALGFGFRCGFLGLLHMDVVQERLEQEFDLGLIMTAPSVDYHAIMNDGSTKVIDNPSDLPDAGEYQEVQEPYVKAEIMVLNDFVGPVMELCQRKRGEFVTMDYLDKYRVNVIYNMPLAEIIFDFFDDLKSSTKGYASLDYEITGYRSTDLVKIDILLNKEPIDALSFIAHRSEAQDRARQMTSMLKKLIPRQNFEVDIQGAIGAKIISRATIKPYRKDVTWKIHTGDPDRRAKLLEKQKRGKKRMKAVGRVEVPQDAFMAVLKMHDDDIKGK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TY3H_DROME
Sequence: MMAVAAAQKNREMFAIKKSYSIENGYPSRRRSLVDDARFETLVVKQTKQTVLEEARSKANDDSLEDCIVQAQEHIPSEQDVELQDEHANLENLPLEEYVPVEEDVEFESVEQEQSESQSQEPEGNQQPTKNDYGLTEDEILLANAASESSDAEAAMQSAALVVRLKEGISSLGRILKAIETFHGTVQHVESRQSRVEGVDHDVLIKLDMTRGNLLQLIRSLRQSGSFSSMNLMADNNLNVKAPWFPKHASELDNCNHLMTKYEPDLDMNHPGFADKVYRQRRKEIAEIAFAYKYGDPIPFIDYSDVEVKTWRSVFKTVQDLAPKHACAEYRAAFQKLQDEQIFVETRLPQLQEMSDFLRKNTGFSLRPAAGLLTARDFLASLAFRIFQSTQYVRHVNSPYHTPEPDSIHELLGHMPLLADPSFAQFSQEIGLASLGASDEEIEKLSTVYWFTVEFGLCKEHGQIKAYGAGLLSSYGELLHAISDKCEHRAFEPASTAVQPYQDQEYQPIYYVAESFEDAKDKFRRWVSTMSRPFEVRFNPHTERVEVLDSVDKLETLVHQMNTEILHLTNAISKLRRPF
What is the function of this protein?
Plays an important role in the physiology of adrenergic neurons.
What are the official names of this protein?
Tyrosine 3-monooxygenase, Protein Pale, Tyrosine 3-hydroxylase, TH.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell projection, axon. Note=Expressed in dopaminergic axons and axon terminals.
Protein: RL21_MYCBO
Sequence: MATYAIVKTGGKQYKVAVGDVVKVEKLESEQGEKVSLPVALVVDGATVTTDAKALAKVAVTGEVLGHTKGPKIRIHKFKNKTGYHKRQGHRQQLTVLKVTGIA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: LCRG_YERPE
Sequence: MKSSHFDEYDKTLKQAELAIADSDHRAKLLQEMCADIGLTPEAVMKIFAGRSAEEIKPAERELLDEIKRQRERQPQHPYDGKRPRKPTMMRGQII
What are the official names of this protein?
Low calcium response locus protein G.
Protein: POLS_ONNVS
Sequence: MEFIPAQTYYNRRYQPRPWTQRPTIQVIRPKPRRSRPAGQLAQLISAVSRLALRTVPQKPRRTRKTKKQKQVKQEQQSTRNQKKKAPKQKQTQKKKRPGRRERMCMKIENDCIFEVKHEGKITGYACLVGDKVMKPAHVKGTIDNADLAKLAFKRSSKYDLECAQIPVHMKSDASKFTHEKPEGYYNWHHGAVQYSGGRFTIPTGAGKPGDSGRPIFDNKGRVVAIVLGGANEGTRTALSVVTWNKDIVTKITPEGSVEWSLALPVMCLLANTTFPCSQPPCAPCCYEKKPEETLRMLEDNVMQPGYYQLLDSALACSQHRQRRNARENFNVYKVTRPYLAHCPDCGEGHSCHSPIALERIRSEATDGTLKIQVSLQIGIKTDDSHDWTKLRYMDSHTPVDADRSGLFVRTSAPCTITGTMGHFILARCPKGETLTVGFVDSRRISHTCMHPFHHEPPLIGREKFHSRPQHGKELPCSTYVHTTAATTEEIEVHMPPDTPDYTLMTQQAGNVKITVDGQTVRYKCKCDGSNEGLITTDKVINNCKVDQCHTAVTNHKKWQYNSPLTPRNSEQGDRKGKIHIPFPLVNTTCRVPKARNPTITYGKNRVTLLLYPDHPTLLSYRSMGRIPDYHEEWITSKKEISITVPAEGLEVTWGNNDPYKYWPQLSTNGTAHGHPHEIILYYYELYPTTTIAVLAAASIVVASLVSLSLGMCICARRRCITPYELTPGATIPFLLGVLCCVKTAKAASYYEAATYLWNEQQPLFWLQLLIPLSAAIVACNCLKLLPCCCKTLTFLAVMSIGARTVSAYEHATVIPNTVGVPYKTLVSRPGYSPMVLEMELQSVTLEPTLFLDYITCEYKTITPSPYVKCCGTAECKAKNLPDYNCKVFTGVYPFMWGGAYCFCDAENTQLSEAHVEKSESCKTEFASAYRAHTASVSAKLRVFYQGNNITVSAYANGDHAVTVKDAKFVIGPLSSAWSPFDNKIVVYKGEVYNMDYPPFGAGRPGQFGDIQSRTPDSKDVYANTQLILQRPAAGAIHVPYSQAPSGFKYWLKEKGASLQHTAPFGCQIATNPVRAVNCAVGNIPVSIDIPDAAFTRVTDAPSVTDMSCEVASCTHSSDFGGAAVVKYTASKKGKCAVHSLTNAVTIREPNVDVEGTAQLQIAFSTALASAEFKVQICSTQVHCSATCHPPKDHIVNYPSPHTTLGVQDISTTAMSWVQKITGGVGLVVAIAALILIIVLCVSFSRH
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to target cell and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits.  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group.
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: RNPA_HELAH
Sequence: MLDELRAEKNFPSKPYDSLKNKSEFDRVYQRGFKKHNSFFSLFVLDASKEPSHFKNPFFCRLKDTEKSCLLGLSVSKKVGNAVKRNLIKRRLRSLVLKHASLCQGFALVFVPKKDCERLDFLTLEKHFLEMLISIKGYMNKKEKGTNHTYAKP
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RUVC_ACTSZ
Sequence: MTIILGIDPGSRVTGYGVIRQTGRTLEYLGSGVIRTQADDLPTRLKRIYAGVTEIITQFQPDMFAIEEVFLAKNPNSALKLGQARGTAIVAAVNRDLPVFEYAARLVKQTVVGIGSADKSQVQDMVARILKLSDKPQADAADALAIAITHAHTIRHSLHVAASAKTTETQEKLTALMRTRYSRGRFRLKV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: AROC_BUCA5
Sequence: MSGNTIGKIFCVTTFGESHGEALGCIIDGTPPGLELSCKDLQYDLNRRRPGTSRYTTLRREPDEVNILSGIFNGVTTGTSIGLIIYNHDHRSQDYSDIKNLFRPGHADYTYEKKYGIRDYRGGGRSSARETAMRVAAGAIAKKYLNEKYGITIRAYLSAMGNIKCPFKSWQEVENNPFFCSDPEKILALENLIKYLKKIGDSIGAEITIIAENIPVGLGEPVFDRLDADLSHALMSINAAKGVEIGDGFSVINQRGSEHRDEITPQGFLTNHSGGILGGISNGREIVLKVAFKPTSSIRKAGNTINKNNEKVQIVTKGRHDPCVGLRAVPITEAMVAIVLMDHLLRFRAQCSGK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: IF3_DEIGD
Sequence: MIDIAKEHKVNEQIRVRQIRLIGAEGEQIGIIDTRDALAMAREKGLDLVMVSPQAVPPVCRLLDYGRFRYEQQQNEKENRKRARAQEVKAIKFRVKIDDHDFNTKTGHVRRFLEEGHKVKVTIMFRGRERTHPELGERILHRVAETLADIGAPEGMPSMMGMDMNMIMVPKAAPKRDSGRSESAQEAPTARSAEASRPEAPANA
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGSA_THET2
Sequence: MKALALIAHDAKKDEMVAFCLRHKDVLARYPLLATGTTGARIQEATGLAVERVLSGPLGGDLQIGARVAEGKVLAVVFLQDPLTAKPHEPDVQALMRVCNVHGVPLATNLVAAEALIAWIRKGTPQ
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: MCPT8_MOUSE
Sequence: MFLLLVLLVAALPVNAEGGEIIWGTESKPHSRPYMAYIRFNDSKSVYRCGGFLVARDIVMTAAHCNGKVINVTLGIHNLKKKKNTQLIPVSEAIPHESFDNETLVNDIMLLKLERKAQLNSAVDTIALPKSKDWVKPGQVCTVAGWGKLANCTLSDTLQEVNLEVQKGQKCRSMSQTYNDSIQLCVGNPSENKATGKGDSGGPFVCNGVVQGIVSCRLCTGTLPRVFTRISSFMPWIRKTMKLLQQP
What are the official names of this protein?
Mast cell protease 8, mMCP-8.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic granule. Note=Secretory granules.
Protein: DBP3_PICST
Sequence: MVEEHKNKKRRQEDGPADVPEKKVKVSKSEKKDKKEKKEKKEKKEKKEKKEKKEKKEKKEKKKKYEHTATISGSAQSSQGYTQSESLTNLPQSEIDSFLATNEVTIEDPHSLNLRPLLSFDQIQLNSKISAVVNKFPTPTPIQSVAWPYLLSGKDVIGVAETGSGKTFAFGVPAINNILTLGKSGLSVLCISPTRELASQIYDNLVDLTSNTNVKCVCVYGGVPKHDQVKNLKNANVVVATPGRLLDLIEDGAVNLGTVDYLVLDEADRMLETGFEDAIKAIIGGTKKENRQTLMFTATWPQEVRKLASTFMNQPVKVSIGDRDELAANKRITQIVEVIEPFDKEKKLLGLLRQYQSGSKKNDKVLIFALYKKEATRIEGLLRRNSYNVAAIHGDLSQQQRTNALNSFKKGESSLLLATDVAARGLDIPNVKVVINLTFPLTVEDYVHRIGRTGRAGQTGTAHTLFTEHEKHLSGALMNILRGANQPVPDELLKFGGHTKKKAHSAYGAFFKDVDMTKTAKKIKFD
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DCNL3_HUMAN
Sequence: MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT
What is the function of this protein?
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:23201271, PubMed:19617556, PubMed:27542266, PubMed:18823379).  At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:26906416, PubMed:25349211).
What are the official names of this protein?
DCN1-like protein 3, DCNL3, DCUN1 domain-containing protein 3, Defective in cullin neddylation protein 1-like protein 3, Squamous cell carcinoma-related oncogene 3.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556).
Protein: ATPF_ACHLI
Sequence: MDIFKEISDAIQEGLNSIFERWDLVLWQIAATVILIIVVRIFLWKPITRYLEQRQEALSKELHEAAHERERVAQIRYELQTEYEVMRKEARQMKDTLMSEAQLEKERIISDARNEAKRRIQQVDRDVQQELRLQSEKIRENIKNIAFDVAEKIVSHQVTDENIDEVIDEMLDEKL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.