PharMolix/UniProtQA huggingface dataset:
Protein: EDC3_YEAST
Sequence: MSQFVGFGVQVELKDGKLIQGKIAKATSKGLTLNDVQFGDGGKSQAFKVRASRLKDLKVLTVASQSGKRKQQRQQQQQNDYNQNRGEHIDWQDDDVSKIKQQEDFDFQRNLGMFNKKDVFAQLKQNDDILPENRLQGHNRKQTQLQQNNYQNDELVIPDAKKDSWNKISSRNEQSTHQSQPQQDAQDDLVLEDDEHEYDVDDIDDPKYLPITQSLNITHLIHSATNSPSINDKTKGTVINDKDQVLAKLGQMIISQSRSNSTSLPAANKQTTIRSKNTKQNIPMATPVQLLEMESITSEFFSINSAGLLENFAVNASFFLKQKLGGRARLRLQNSNPEPLVVILASDSNRSGAKALALGRHLCQTGHIRVITLFTCSQNELQDSMVKKQTDIYKKCGGKIVNSVSSLESAMETLNSPVEIVIDAMQGYDCTLSDLAGTSEVIESRIKSMISWCNKQRGSTKVWSLDIPNGFDAGSGMPDIFFSDRIEATGIICSGWPLIAINNLIANLPSLEDAVLIDIGIPQGAYSQRTSLRKFQNCDLFVTDGSLLLDL
What is the function of this protein?
Stimulates decapping of both stable and unstable mRNA during mRNA decay.  Does not affect nonsense-mediated mRNA decay.  Required for normal P-body assembly.
What are the official names of this protein?
Enhancer of mRNA-decapping protein 3.
What is the protein family that this protein belongs to?
Belongs to the EDC3 family.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: MINC_XYLFM
Sequence: MSNVNMDFEQAGELKIGQVGIATLRIRTLNVPRLIQEMSDRVTRAPKLFRRTAVILDFGELPHPPDLTTAKALVDGLRAANVLPVAIAYGTNEIDLLSQQLGLPLLSKFRAHYERQEVAAPPPQSTPPINTGRIQHTTVRSGQQLYAEHCDLTILNTVGAGAEVIADGNIHIYGTLRGRAMAGARGNAEMRIFCRDFQAELIAIAGRYKVLDDIPTELRGKAVQVWLEQNQIKIAALD
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: PROA_YEAST
Sequence: MSSSQQIAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGLADSLLKRLDLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLVIFESRPEVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVGSVQLIETRQDVSDLLDQDEYIDLVVPRGSNALVRKIKDTTKIPVLGHADGICSIYLDEDADLIKAKRISLDAKTNYPAGCNAMETLLINPKFSKWWEVLENLTLEGGVTIHATKDLKTAYFDKLNELGKLTEAIQCKTVDADEEQDFDKEFLSLDLAAKFVTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGVYWNASTRFADGFRYGFGAEVGISTSKIHARGPVGLDGLVSYQYQIRGDGQVASDYLGAGGNKAFVHKDLDIKTVTL
What is the function of this protein?
Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, GSA dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
Protein: NFUA_SHIBS
Sequence: MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEATDTALKFDLLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVADDAPLMERVEYMLQSQINPQLAGHGGRVSLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEKQLLNEFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: SYR_WOLPM
Sequence: MNIFKQISSLIFSKLNELKQRGVISTSAANFIIEPPSNRVHGDIYTNVAMVLAKHEKKNPIEIAEVLAKEFELFDEVAKVEIAGSGFINMHLKIEVWHGILKQINELKTEFGTLDIGNNQAINVEFVSANPTGPLHIGHARGAVFGDVLANLLKKVGYKVTKEYYINDAGAQIDTLIRSVYLRYKEALGEKISIEKGLYPGEYLKPIGTGLAKKYGAELLEKQDNQVIRDYTLSSILEIIKEDMNLLGVNHDVFTSEYELQKSGKIEESIKILSDKGLVYEGYLEKPKGKESENWTSRKEMLFRSTKFGDDVDRALKKEDGSWTYFASDIAYHFDKISRGFNNMIVELGSDHGGYVKRLKAVVSALSDDQAKIEVKLHNIVNFFENGKPVKMSKRSGNFLTARDVVEEVGRDITRFIMLTRKNDMVLDFDFAKVKEQSKDNPIFYVQYAHARAHSLMRNAPKELPTADPSLLRTGGELFLIKTLAKWPDVVEIAARLCEPHRITFYLLEVAEAFHVLWGYGKSDLNMRFILEDNLNLTAARMFLVQALAHVIASGLSIFNIEPLEEMS
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC1_SYNC1
Sequence: MMRKFHEITGTETGAVSGEAGTIGTRKVYVTGSRPDIRVPMKEIVQKVGAQDESGTELLKIYLYDTSGPFTDPGAAVNIRAGLPAMREAWIEERHDSMVLSQLSSEYGRQRLAGRVEGGQYFPEERLPRRAGKGCNVTQMHYARKGIVTPEMEYIAIRENQRRESLPELLKKQHPGDPRGTRMPQVITPEYVRDEVAAGRAVIPCNINHPECEPMIIGRNFLVKINANIGNSAMSSSIDEEVEKMIWAIRWGGDTVMDLSTGVDIHETREWIIRNSPVPIGTVPIYQALEKVGGQAEELSWEIFRDTLIEQAEQGVDYFTIHAGVRSNLLEAAQRRLTGIVSRGGSIMTKWCKAHGQESFLYTRFEEICEIAKAYDVTFSLGDGLRPGSIYDANDEAQIEELKTLGELTETAWRHDVQVMIEGPGHVPMHMIQENMDLQLKYCHGAPFYTLGPLVTDIAPGYDHITSAIGGTMMAWCGTAMLCYVTPKEHLGLPDKNDVREGIVAHKIAAHAADLAKGHPGAQARDNALSKARFEFRWQDQFALGLDPERAMGIRKALLPEDAEDKEQYCTMCGPDFCSMKITRSLREGAAGGKEE
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase 1, Hydroxymethylpyrimidine phosphate synthase 1, HMP-P synthase 1, HMP-phosphate synthase 1, HMPP synthase 1, Thiamine biosynthesis protein ThiC 1.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: KATG_HALH5
Sequence: MDTNNTGKCPFHHGATTSPKSSGTTNNDWWPNALNLNILRQHDKKSNPMGEEFDYAEEFSKLDYDALKQDVRDLMRDSQDWWPADFGHYGPFFIRMSWHAAGTYRIGDGRGGGGTGNQRFAPLNSWPDNGNLDKARRLLWPIKQKYGNKISWADLLVLAGNVAIEDMGGPVIGFGAGREDIWHPEEDIYWGSEKEWLTGDKRYSGDRELENPLAAVEMGLIYVNPEGPDGKPDPIKAAHDIRETFGRMGMNDEETVALIAGGHTFGKAHGAGNPDHVGPEPEAAPIEAQGLGWQNTYGSGKGRDTITSGLEGAWTANPTQWDNGFFDLLFGYEWWLTKSPAGAYQWQAVDPDEKDLAPDAEDPSVKVPTVMLTTDLALRHDPEYEKISRRFHKNPDEFADAFARAWFKLLHRDMGPKARYLGPEVPAEDFIWQDPVPTVDYELTDAEVEELKAKILDSGLTVSELVTTAWASASTFRNSDKRGGANGARIRLAPQKDWEVNQPEQLEKVLSVLENIQSQLDKKVSIADLIVLGGSAAVEKAAKEAGFDVTVPFAPGRGDATQEQTDVEGFAVLEPVSDGFRNYQKKEYSVSPEELLIDKAQLLDLTAPEMTALIGGMRALGANYGGTQHGVFTDCVGTLTNDFFVNLLDMGIEWKPVDYNLYEGRDRKTGEVVRTATRVDLVFGSNSILRAIAEVYAQDDNKGKFVEDFIAAWVKVMNADRFDLKLNKKAQLTSK
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: ADEC_ECO57
Sequence: MNNSINHKFHHISRAEYQELLAVSRGDAVADYIIDNVSILDLINGGEISGPIVIKGRYIAGVGAEYTDAPALQRIDAHGATAVPGFIDAHLHIESSMMTPVTFETATLPRGLTTVICDPHEIVNVMGEAGFAWFARCAEQARQNQYLQVSSCVPALEGCDVNGASFTLEQMLAWRDHPQVTGLAEMMDYPGVISGQNALLDKLDAFRHLTLDGHCPGLGGKELNAYIAAGIENCHESYQLEEGRRKLQLGMSLMIREGSAARNLNALAPLINEFNSPQCMLCTDDRNPWEIAHEGHIDALIRRLIEQHNVPLHVAYRVASWSTARHFGLNHLGLLAPGKQADIVLLSDARKVTVQQVLVKGEPIDAQTLQAEESAKLAQSAPPYGNTIARQPVSASDFALQFTPGKRYRVIDVIHNELITHSHSSVYSENGFERNDVCFIAVLERYGQRLAPACGLLGGFGLNEGALAATVSHDSHNIVVIGRSAEEMALAVNQVIQDGGGLCVVRNGQVQSHLPLPIAGLMSTDTAQSLAEQIDALKAAARECGPLPDEPFIQMAFLSLPVIPALKLTSQGLFDGEKFAFTTLEVTE
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: CLSC_ECOLI
Sequence: MPRLASAVLPLCSQHPGQCGLFPLEKSLDAFAARYRLAEMAEHTLDVQYYIWQDDMSGRLLFSALLAAAKRGVRVRLLLDDNNTPGLDDILRLLDSHPRIEVRLFNPFSFRLLRPLGYITDFSRLNRRMHNKSFTVDGVVTLVGGRNIGDAYFGAGEEPLFSDLDVMAIGPVVEDVADDFARYWYCKSVSPLQQVLDVPEGEMADRIELPASWHNDAMTHRYLRKMESSPFINHLVDGTLPLIWAKTRLLSDDPAKGEGKAKRHSLLPQRLFDIMGSPSERIDIISSYFVPTRAGVAQLLRMVRKGVKIAILTNSLAANDVAVVHAGYARWRKKLLRYGVELYELKPTREQSSTLHDRGITGNSGASLHAKTFSIDGKTVFIGSFNFDPRSTLLNTEMGFVIESETLAQLIDKRFIQSQYDAAWQLRLDRWGRINWVDRHAKKEIILKKEPATSFWKRVMVRLASILPVEWLL
What is the function of this protein?
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).
What are the official names of this protein?
Cardiolipin synthase C, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily.
Protein: THF1_NOSP7
Sequence: MNNVRTVSDTKRTFYNLHTRPINTIYRRVVEELMVEMHLLSVNIDFSYNPIYALGVVTTFDRFMQGYEPERDQESIFNALCRAIEQDPQHYRQDAERLQAIAKGLPVKDLIGWLGQTTYLDRDADLQAQLQAIANNPNFKYNRLFAIGVFSLLEQSDPELVKDEKQLTEALKAIAAGLHVSDDKLNKDLELYRSNLDKMAQALVVMADMLSADRKKREQRKQQSTAPVAPPSSNE
What is the function of this protein?
May be involved in photosynthetic membrane biogenesis.
What are the official names of this protein?
Protein Thf1.
What is the protein family that this protein belongs to?
Belongs to the THF1 family.
Protein: ISPH_PSYWF
Sequence: MQIYLANPRGFCAGVDRAIAIVNEALARFEPPIYVRHEVVHNKFVVSDLANRGAVFVEELHEVPDGSIVIFSAHGVSKAVEDEAERRDLTVFDATCPLVTKVHIEVAKFAREKMDAVLIGHQGHPEVEGTMGRFSAQYGGEIHLVENEADVEKLEVSDPDRLAFVTQTTLSMDDTAVVIDALRKKFPNIQGPRKDDICYATQNRQDAVKDLAQRCEVVLVVGSPNSSNSNRLRELAERMNCKAYLIDNAGEMKKEWFAGVGAVGVTAGASAPEILIQEVLNQLQQWGGDLPDELKGIEENVTFSLPKELRIPVKEVGL
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: USPB_YERPS
Sequence: MISTVALFWALCVVCVVNMARYYSSLRALLVVLRGCDPLLYQYVDGGGFFTSHGQPSKQIRLVGYIFAQRYLDHHDPEFIRRCERLRGQFILTSALCGLVVVSLVALMLWY
What are the official names of this protein?
Universal stress protein B.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ENGB_DECAR
Sequence: MPLFQKAVFLTTVANLRDLPQDSVREVAFAGRSNAGKSSAINTLAGRVRLAFVSKTPGRTQHLNYFTLDEGKYFVDLPGYGYAKAPEAIRSQWEGLIGPYLSKRDQLAGLVVIMDIRRPMTDLDLRLIDWFRPTGRPIHILLSKSDKLSRQDQTKALRSVKAEVATWGDADLYSVQLFSSLKKAGVEEAERVLASWLDIEIKQKENKGPPDKGSPGAKMP
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: GSPC2_ECOH1
Sequence: MARVVFRDARIYLIQWLTKIRHTLNQRQSLNTDKEHLRKIVRGMFWLMLLIISAKVAHSLWRYFSFSAEYTAVSPSANKPPRADAKTFDKNDVQLISQQNWFGKYQPVATPVKQPEPASVAETRLNVVLRGIAFGARPGAVIEEGGKQQVYLQGERLDSHNAVIEEINRDHVMLRYQGKIERLSLAEEGHSTVAVTNKKAVSDEAKQAVAEPAASAPVEIPTAVRQALTKDPQKIFNYIQLTPVRKEGIVGYAVKPGADRSLFDASGFKEGDIAIALNQQDFTDPRAMIALMRQLPSMDSIQLTVLRKGARHDISIALR
What is the function of this protein?
Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane.
What are the official names of this protein?
Type II secretion system protein C 2, T2SS protein C 2, General secretion pathway protein C 2, Type II secretion system protein C beta.
What is the protein family that this protein belongs to?
Belongs to the GSP C family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TCAF3_MOUSE
Sequence: MATTPDAAFETLMNGVTSWDLPKEPIPSELLLTGESAFPVMVNDKGQVLIAASSYGQGRLVVVSHESYLLHDGLVPFLLNVVKWLCPCPGAPIAVHSSLASLVNILGDSGINALVQPEPGEALGVYCIDAYNDALTEKLIQFLKNGGGLLIGGQALNWAAHHGHDKVLSIFPGNQVTSVAGVYFTDISANRDWFKVSKEIPNLRLYVQCEDELEDDQQQLLKGMSEIYIEAGVIPSQLLVHGQRAFPLGVDNSLNCFLAAARYGRGRVVLGGNESLILNQTMLPFVLNALHWLMGNQTGRIGLASDMKVLKSMLPNSSFQWSESELLTSDLSVFCCCSLANIDSEEVEEFVAEGGGLLIGAEAWSWGRRNPYSSCMTQYPDNIVLKRFGLGITSHVAQRGSFPFPNPEGTNYHFRRALSQFESVIYSRGSSLHESWLNKLSQDCFYMFQMTHQRISIYDSVKKHALKMIQSKDFPSVTEQYPIARGSSQAFLLSLAYELFKSGVDRSQLLPPPALLPPTESPITIKISTDNDNSWVSTGLYLPEGQVAQVLLPSEATHAKLKVLIGCHRDNISQARTYFRPPVMTYVYHLTSSQTSISWLYGGLLYIMVPNKYNQDNVSVTIRGAVSAPYFRLGKTTQEEWKNLITHSKAPWGELATDNIILTIPTVNLKELQDPYPLLQLWDKMVRAVAKLAARPFPFQRAERVVLDKQISFGFLHSGYPIMGLISIVEGIISEFKIRSHGIWGVIHELGHNHQKSGWTFPPHTTEALCNLWTIYVHETVLNIPREQAHPSLNPELRRQRIKYHLNKGAPLSNWIMWTALETYLQLQEGFGWEPFIQVFADYRTLSGLPQNNEDKMNLWVKKFSEAVHKNLAPFFEAWGWPVKYAVAKSLASLPEWQENPMKRYTAEGTEGRE
What is the function of this protein?
May play a role in the regulation of the cation channel TRPM8 activity.
What are the official names of this protein?
TRPM8 channel-associated factor 3, Experimental autoimmune prostatitis antigen 2.
What is the protein family that this protein belongs to?
Belongs to the TCAF family.
Protein: HS3S2_HUMAN
Sequence: MAYRVLGRAGPPQPRRARRLLFAFTLSLSCTYLCYSFLCCCDDLGRSRLLGAPRCLRGPSAGGQKLLQKSRPCDPSGPTPSEPSAPSAPAAAVPAPRLSGSNHSGSPKLGTKRLPQALIVGVKKGGTRAVLEFIRVHPDVRALGTEPHFFDRNYGRGLDWYRSLMPRTLESQITLEKTPSYFVTQEAPRRIFNMSRDTKLIVVVRNPVTRAISDYTQTLSKKPDIPTFEGLSFRNRTLGLVDVSWNAIRIGMYVLHLESWLQYFPLAQIHFVSGERLITDPAGEMGRVQDFLGIKRFITDKHFYFNKTKGFPCLKKTESSLLPRCLGKSKGRTHVQIDPEVIDQLREFYRPYNIKFYETVGQDFRWE
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:9988768).  Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS (PubMed:9988768).  Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:9988768).
What are the official names of this protein?
Heparan sulfate glucosamine 3-O-sulfotransferase 2, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2, 3-OST-2, Heparan sulfate 3-O-sulfotransferase 2, h3-OST-2.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: HDAC1_BOVIN
Sequence: MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKQEAKGVKEEVKLA
What is the function of this protein?
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.  Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity).  Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3.  Deacetylates SP proteins, SP1 and SP3, and regulates their function.  Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons.  Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation.  Deacetylates TSHZ3 and regulates its transcriptional repressor activity.  Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.  Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (By similarity).  Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.  Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer.  Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity).  In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (By similarity).
What are the official names of this protein?
Histone deacetylase 1, HD1, Protein deacetylase HDAC1, Protein decrotonylase HDAC1.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: FAX3_ARATH
Sequence: MMSIPMELMSIRNPNSTLLYRAHSRPPVKLCAPPRSLLPSRRHFSAPRAVVSYPGIRFGFTSPEVLLNRSVVAFAASHEDSGESGVEVGKEKSDIDVEDDTSKEAWKQTLESFKEQVSKMQSVSSEAYSVNSQKAMTVLKETSEQLRIQAEKAKEELGTKAKVVSEEGREYILKAAEESPSDVKEIVEAFASTEDLKNVSRANDFHVGIPYGLLLLVGGFINFMVSGSIPAIRFGVILGGALFALSLASLKSHRKGESSTKFLKGQMAIVAIIFLRELRLLLSQKSTFLGFFTTLTSGGVLGFYLYKMVVKREKGPTLEDGGEDESSDGFVRSEG
What is the function of this protein?
May be involved in free fatty acids export from the plastids.
What are the official names of this protein?
Protein FATTY ACID EXPORT 3, chloroplastic, At-FAX3.
What is the protein family that this protein belongs to?
Belongs to the TMEM14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: FKBP3_CANGA
Sequence: MSDMLPLATYSLNVLPYIPTPAIDIEMPVTVRITMAALDPEALDDQKQPSTLRIVKRNPNFDDEEYDDLLNGDYDEDEMASDDEEEEEEEEEEEKPAKKSKKSKGKKKDESEDEEEEEESDSDLDEEDDDDEFEEYVLATLSPKTQYQQTLDLTIAPEEEIQFIVTGSYAISLVGNYIKHPFDTPMGDMDDSEDEDGSDYDDELSDSYYNDQYSDDDAEDSDEHDLTPDEDELAPAGSVEEIEASEEEESEEEEKKSKHKKHDHHHHHDHDHDHDHEHKSKNKKRKQEEEEPKKEHKDKKVKFKKDLEEGPTKKEKAESKKADKTPKRRTLEGGVVIEDRTVGDGPAAKKGDRVGMRYIGKLKNGKVFDKNTSGKPFVFKLGRGEVIKGWDVGVAGMSVGSERRIIIPAPYAYGKQALPGIPANSELTFDVKLVSIK
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
FK506-binding protein 3, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: YEEX_ECOLI
Sequence: METTKPSFQDVLEFVRLFRRKNKLQREIQDVEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKGDYEDRVDDYIIKNAELSKERRDISKKLKAMGEMKNGEAK
What are the official names of this protein?
UPF0265 protein YeeX.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: S35D2_PONAB
Sequence: MAEVHRRQHARVKGEAPAKSSTLRDEEELGMASAETLTVFLKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQMVATVAVLWVGKALRVVKFPDLDRNVPRKTFPLPLLYFGNQITGLFSTKKLNLPMFTVLRRFSILFTMFAEGVLLKKTFSWGIKMTVFAMIIGAFVAASSDLAFDLEGYVFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYFTGDAQKAVEFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIGMVFGGDYIFTWTNFIGLNISIAGSLVYSYITFTEEQLSKQSEANNKLDIKGKGAV
What is the function of this protein?
Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars).  May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter, Solute carrier family 35 member D2.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: LIPB_ENT38
Sequence: MYQDKILVRHLGLQPYEPVSQAMHDFTDSRDDHTPDEIWLVEHHPVFTQGQAGKAEHVLVPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVDTLAEYDIDAHPRADAPGVYVGEMKICSLGLRIRKGCSFHGLALNINMDLSPFLRINPCGYAGMEMTQMRQWVENATPGIIGPLLVSKLLALLNNPPHEYIPA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMY_METBU
Sequence: MRNFVIIAHKALTTGDFSLNDLPGSAGRMDILCRCINSCLFLSHDLRRDVQVHLLLLGEPEPGKIIRFDSEHVRYLNPDERSAGSLIKKALQKTAGEYEVRSTPGVFIRSGNLGTLLNEFKDAGRRLIYLHEDGEDIRELSDLTNNAVFILGDHMGVTEEEEQLIKEHEAKTISLGPIPLHADHCIILINNEIDRNLSGKSQ
What is the function of this protein?
Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.
What are the official names of this protein?
tRNA (pseudouridine(54)-N(1))-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. TrmY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOXC_DICDI
Sequence: MEKQKNISIKKFANPLSFPHEFRTNLHKSTFLDASLLELPNISVDKTKNENNFSITDKILMESLKENEFKIREFIKNQESGNRVLMIDKNSLKELFNINDNQALDLIFNQYVQSTRPNLIRKSSNSSLNIDLKKEIKKKTKKSRKSFSRNSKLNNNDSKIDDKNDNYIDKINDINNFNSDIEEIFKKKKEIENTLKIPIGGNSFPIPVEFNNNNNNNNNNNNNNNNNYNNNIDNNNNNNNNNNNNNINNCNNNNINNDNNNNNNNDNDNNNINTVDNHDDDIINNSNNFNKNEYPSSNISPISPKSSISSFPTNLNNSINNTGSMVSDSLSSCRNSISSSSIDSSVASIPITIQSIDFEDKNIKSDQFKIISKSNIENTIETNPIPPFNQTNNQCEVQLQSHSLPTILKQPHIYKSKSFSSSINSNSKIKKIKKSRSFEIESKINLFDVINHIYLNLSKVGSEEQKITSVFKLYDIYDKGFISRDDLKEVLNYRTKQNGLKFQDFTMESLIDHIFQQFDKNMDGYIDFEEFKSELTINNENKVKEKEENTNYNFKEENIGIYTEKESFHSLKRYLKIEGSKLFFISLFFIINSILVITSFLNVHANNKRAIELFGPGVYITRIAAQLIEFNAAIILMTMCKQLFTMIRNTKFKFLFPVDKYMTFHKLIGYTLIIASFLHTIGWIVGMAVATGKPDNIFYDCLAPHFKFRPTVWEMIFNSLPGVTGFIMISFLIIMAILSLKIIRKSNFELFYYSHHLFIGFYVLLILHGTMGWIRPPTFWKWFIVPGFFYTVDRSFRLFKRTHRVEVLDYCLKNERVINLTFSKPPSFDYKPGQYLLINVPHISKLQWHPFTMTSSPLEDKIYVHIRVTGNWTKKLFRWLSIKKQLQQQQQLYNNIKQQNVLPDGSNFIINNNNNIDQIDLEIGLKPFRINIDGPFGSSSQYALKQKQVILVGAGIGVSPMASLLKDISLKKQRLQLLNQGDQIALEQSKNEITTKFGLGNLEKVHFFWLNRDQHSFQWFEDLLIDISTNGNSNLPKISINTFNTRVFPKNDVRVFMLWNGLDKLFKAQGLDPTTNLPFKTHWGRPNWDTIFQYYSKKYSGESISVFCCGPSQLSKELYEKCRYYTCLKTGGTKFYFHKENF
What is the function of this protein?
Critical component of the membrane-bound oxidase that generates superoxide.  It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior (By similarity).
What are the official names of this protein?
Superoxide-generating NADPH oxidase heavy chain subunit C, NADPH oxidase C, Superoxide-generating NADPH oxidase flavocytochrome C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.