PharMolix/UniProtQA huggingface dataset:
Protein: DNAA_ECOLU
Sequence: MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLTSFCGADAPQLRFEVGTKPVTQTPQAAVTSNVAAPAQVAQTQPQRAAPSTRSGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTHLLHAVGNGIMARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTH1_KLULA
Sequence: MSIVHPDTSKYEFNFEPFLRKEYSFSLDPDRPVCQYYNSREGIKSCPNGARCPNKHVLPIFQNKIVCKHWLRGLCKKNDQCEYLHEYNLRKMPECVFFTKNGYCTQSPECQYLHVDHKSQLEECEDYNMGFCPSGPACTKKHVKKVLCPRYLVGFCPLGKDCDWSHPKFKVPSEHSKLRIKKDEHINTRKMDEERERRLNAIINGDILVT
What is the function of this protein?
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
What are the official names of this protein?
mRNA 3'-end-processing protein YTH1.
What is the protein family that this protein belongs to?
Belongs to the CPSF4/YTH1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS15_AYWBP
Sequence: MALTKEQKQEIIKQNSHFAKDTGSSEVQIAILSAEIKQLSEHLKQHPHDFHSKRGLFMKNSKRRNLVKYLANQN
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: Y482_MYCPN
Sequence: MNDLALALGLGIPLSLLVGVIIGYFISIKIFKKQIRDNPPITENQIKAMYAKMGRKLSETQVKEIMRSIKNQK
What are the official names of this protein?
UPF0154 protein MG335.1 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: CO039_MOUSE
Sequence: MAEKRPLGPLGPMMYGKLPRLEPDPGPGHSLPLSASSQDSCNYKGAYFSCPIGGTSKAGSERLASWTPYPSLYPTGVAGSPLRGDNLLTNCLLYRPPTEGSEKIQDSSELLPFGPQAHAYPGPPLAAPKPVYRNPLCYGLSTCLGDGGTKRSLDGDWTLVTGPLLPSADPPCPLATAPGKGQPLDGTFLRGLPSGGPGKDSSLPFSPCQAFLEKYRTIQSTGFLASKYTSPYPGDAKQAMSEGPSSPWTQLAQPLGPPCQDAVAAHYPLPPPPQALPCPPSCHPEKQGSYGSLLPLPPLGAHKGAAYQAGGLGSPYLRQQAPQAPYMPPLGIDSYSYSSAPLPAPSPGLKLEPPLAPRCPLDFVPQTLGFPYARDDLSLYGASPGLGGTPPSHSQNSVQPVPQPGAFQRACQPLPASQPCSEPVRPAEKPTPEAQEKMWLPSCRKEQLQPRPNERPGVPIVIRDSPVPRTSPALHPCAKERQSVPQKDARPPSSPPMPVIDNVFSLAPYRDYLDVQTPEPRAERDSAPATSKSQDKDCKGNLPAQDGASRSHCSLREEVALDLSVKKTMAEGVPVKVPSPEVHEKPAEAVDGPGIENTVSGLPGLKKMVTEIPEVTAEATPRTNFHSSVAFMFRKFKILRTAPVPAAIVSSPTTPAPVPAPAPAQPVPNPPSVPVGLQILTQPLPVACFNLALPSPPAIVASPAPASAPPPSPAPAPAPASGPAPSSAQVPTAAPVDSPEQHFTGLHTSLCDAISGSVAHSPPEKLREWLETTGPWGQAAWQDCQGVQGLLGKLLSQLQKFVCTQRCPFPHVVRAGAIFVPIHLVKERLFPKLPPASVDHVLQDHRVELRPTTLSEERALRERALHGCTSRMLKLLALRQLPDIYPDLLGLQWHDCVRRQLGGFDTEARTLSPSEPTVTRDEPESQALAGKLPAPKVKKPGRKPPTPGPEKAEAATGEGSRNPSPSSGASTSPPGPTLRARFRNLLENAWLNGVALPTWGHKASGADRSSPHPQLLGSQTHHL
What are the official names of this protein?
Uncharacterized protein C15orf39 homolog.
Protein: CCR4_ASPNC
Sequence: MNGGQAHQRFGMQIPKFQSQSHHPHPAQQAHHHAHHNQASHSINHQHNFSSGALAAATPHFTPGPLQNGAHVNVDEDIDETMNEHWQQQLQLAAESRQASSPHYYARTVAQQTKGIQIAPSQPESQENGSGDRNGLVKSKPAPRQGWHALDFGGQGLRALATSLFHYTFLEKLYLNHNKLKTLPPAIGQLRKLTHLDLSSNDISELPEEIGMLTSLKQLLLFDNNIRTLPFEMGYLYRLEMLGIEGNPLNDVLKSQIIKEGTKALVRYLREEMPVHLPPPDRDWIILDETASSSNSPTEKITVLSHNALCDSSATPSHFGYTPSRVLSWEFRRELILSELRSHDSDIICLQEIDQGSYNGFFREQLAYNDYKGVYWPRGRAMGMQEEEAKSVDGCATFFKGSKFILLDKQMINFGQTAVRRPDAKGQDDIYNRLWQKDHIAVVIFLENRLTGSRFIVVNAHLYWDPAFKDVKLIQTAILMEEITKLSEKYAKFPPCTDKTAFRFSEAEVEYASGDQIPLFMCGDFNSAPGSAAYNLVAHGRLTESHPDLEKRLYGNLSRVGMTHPFKLKSAYNSIGELSFTNYTPDFKDILDYIWYTSNTLHVSALLGEVDKEYLQKVPGFPNFHFPSDHVALFAEFTVKGKKGKVVEADFGPQRN
What is the function of this protein?
Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity).  Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
What are the official names of this protein?
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4, Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: END4_THEAB
Sequence: MIRIGAHMPIGGGFKRVPKETYEIGGNAFQIFPHNPRQWKANLPKEEDIKLFKEGIKKYKIDPEAMLCHSGYLINIASPNIETWNKSLELLILEMKICSTLGIKYLNIHPGSHLKSGVENGINQILKALNTAMEKEKNTFILLENVTKKGGNIGSTLEELKLIIDKAKFPDRLGITIDTCHAFDAGYDITNKEKLNEFLNKIDKYFSLEKLKFIHLNDSKNDLGSNKDRHENIGKGKIGSEGLKVFISHPLIQKIPWVLETPGDNDVHKKDIQEVLKILEVK
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: TRPA_PHOV8
Sequence: MNRINQLFSTKQKDILSIYFCAGFPTLEGTASTIKVLEKKGINMIEIGIPFSDPMADGPVIQHAATRALKNGMTLKLLFDQLKDIRKEVQIPLVLMGYLNPIMQYGFKDFCRTCRETGIDGVIIPDLPFKDYMEEYRSIAEEQDVRIIMLITPETSEERIRLIDEHTDGFIYMVSSAAITGAQKDFNAQKQAYFQRIADMNLRNPRMIGFGISNKQTFETASAHAAGAIIGSKFVTLLDEEDGDTEKAADKLLEALKN
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RK23_PHAAO
Sequence: MDGIKYAVFTEKSIRLLGNNQYTSNVESGSTRTEIKHWVELFFGVKVIAMNSHRLPGKGRRMGPIMGHTMHYRRMIITLQPGYSIPPLIEKRT
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L23, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSA2_MOUSE
Sequence: MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
What are the official names of this protein?
Proteasome subunit alpha type-2, Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3, Proteasome component C3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (PubMed:22078707).
Protein: PDXA_METEP
Sequence: MASDDRPLALTLGDPSGIGPEIALAAWQLRGERGVPPFQLIGDPEFLEATAYRLGLSVPVAEVEPDDACEVFPRALPVLPLPSGAKVIATPGAPDSANAGAIVESITAAVDLVRSGAASAVVTNPIAKFVLTRVGFAHPGHTEFLAALAAREGREPPLPVMMIWSDTLAVVPVTIHVALRRVPELLTQDLVERTARIVHADLRARFGLEHPRLVLSGLNPHAGESGTMGTEDRDVLAPAVAVLRSEGIDIRGPLPADTLFHERARATYDVALTPTHDQALIPVKTLAFDEGVNVTLGLPFVRTSPDHGTAFDIAGKGIAKPDSLIAALRLAHRLAHRPADTVLPFPVRA
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QWRF9_ARATH
Sequence: MTAATISPSFNANVKQNKPPSFPSESSNRRPKTRDVASRYLGGTSSFFHQSSPKRCQSPIVTRPVTPSSVATNRPQSTPRRESLDRREVSKAERMLLTSGRSLFASFQADSFTPGTLERRKTTSSATISKSGGGKQEKLKLSDQWPRSLQPSCLSSRSVDFTDTRKKLIGSGNGVARALQDSMVSNRPVSRERITSVDLETESVSSGSSNGRGKMLPARGNVVKARVSQDRLEPSSHGLRKISVDSSVLSPKEANSLSSPRGTSIARGLSPSREVVPPRGVSPSDRMSPLRVRSSLSKNTPLIPHFAVDGKEKIRDNGVADAHLLRLLHSRLLQWQFANARANAVISSQKMREERRLYNAWRSISNLYNSVSMKRIEMQHLKQNLKLISILNMQMGHLEEWLVIDRNYMGSLVGAAEALKGSTLCLPVDCGAMVNVQSVKDAICSAVDVMQAMASSICLLLPKVGKISSLAAELGRVNAKDEGMLDVCRDLLNTISALQVTECSLRTQVTQLQ
What are the official names of this protein?
QWRF motif-containing protein 9.
What is the protein family that this protein belongs to?
Belongs to the QWRF family.
Protein: VAV_HUMAN
Sequence: MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEEDYSEYC
What is the function of this protein?
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
What are the official names of this protein?
Proto-oncogene vav.
Protein: NU4C1_SYNJA
Sequence: MSNSLEFPWLSALVLLPLLAAFGIPLLPQSRWARWYALAVGALDLGLMAYIFGWHYDLRDFSLQLAERYAWVPQIGFHWSLAVDGLSFPLVLLSGLITTLAIVAAWNLTHKPRLFFFLLLLMYGAQVGVFLAQDLLLFFLMWEIELVPVYLLIAIWGGPQRQYAATKFILYTAAASIFILVGSLAMAFGSEGFSLEMAELGAKSYPLALQILAYAAFLIAFGVKLPVFPLHTWLPDAHSEASAPISMILAGVLLKMGGYGLIRLNVGILSEAHVYFAPVLAVLGAVNIVYGALAALGQNYLKRRLAYSSIAHMGFVLIGIAAFTELGLNGALLQMISHGLIAAVLFFLTGITYERTHTLALDKLGGLAKQMPKAFALFTAGSLASLALPGMSGFVGELTVFLGLITSDAYAPTFKAGIALLAAVGIILTPIYLLSMLRQVFYGAQDPGLVLEDYLGDLRPREMAVALCLLLPILGIGLYPRLATQTYDVTTVAVAAQLRSALPTEIVQRPLLPVQPAQVAALPPTD
What is the function of this protein?
NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4 1, NAD(P)H dehydrogenase I, chain 4 1, NDH-1, chain 4 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PEPE_MYCBO
Sequence: MGSRRFDAEVYARRLALAAAATADAGLAGLVITPGYDLCYLIGSRAETFERLTALVLPAAGAPAVVLPRLELAALKQSAAAELGLRVCDWVDGDDPYGLVSAVLGGAPVATAVTDSMPALHMLPLADALGVLPVLATDVLRRLRMVKEETEIDALRKAGAAIDRVHARVPEFLVPGRTEADVAADIAEAIVAEGHSEVAFVIVGSGPHGADPHHGYSDRELREGDIVVVDIGGTYGPGYHSDSTRTYSIGEPDSDVAQSYSMLQRAQRAAFEAIRPGVTAEQVDAAARDVLAEAGLAEYFVHRTGHGIGLCVHEEPYIVAGNDLVLVPGMAFSIEPGIYFPGRWGARIEDIVIVTEDGAVSVNNCPHELIVVPVS
What are the official names of this protein?
Probable dipeptidase PepE.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APTH1_CANAL
Sequence: MSVSAIRIPANGSSAKAAVIFLHGLGDSGDGWSWLPQLVSQSKLINDPINYVFPNAPKIPVTINNGFAMPAWFDIYELGNPHAKQDVTGFFKSCEVLKEFILEQHNKFNIPLEKIIIGGFSQGAAISLATLALLDTKIGGCVALSGFCPVRNEITDRYNKNPGVNFDTPIFQGHGTVDPVINYDYGKQTSELYKQLGFKNLKFNTYEGVAHSASEEELADVIKFIKNIVEK
What is the function of this protein?
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates.  Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins.  Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
What are the official names of this protein?
Acyl-protein thioesterase 1, Palmitoyl-protein hydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PLSX_PARPJ
Sequence: MTVKLTIDCMGGDHGPSVTVPAAVNFVRSHPDAELLLVGIESAIRAQLKKLKAQDLPALTVVPASEIVAMDDPVEVALRKKKDSSMRVALNRVKEGEAQACVSAGNTGALMAVSRYVLKTLSGIERPAIASALPNPNGYTMMLDLGANVDCEPQHLLQFAEMGHALVSALEGKDRPTIGLLNIGEEVIKGNDTIKRAGELLRASTLNFHGNVEGNDIFKGTVDVIVCDGFVGNVALKTSEGLAQMLSNIIKEEFGRSWLTKVMAVLALPVLMRFKKRVDHRQYNGAALLGLRGLVIKSHGSADAYGFEWAIKRGYDAVKNGVLERLARAMEENAGSLEQAARDASGAGQASPIAGQPAEPYAAQSSKA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: PDHR_ECOLI
Sequence: MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFSDPLVELLSDHPESQYDLLETRHALEGIAAYYAALRSTDEDKERIRELHHAIELAQQSGDLDAESNAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQNVRQNFELLYSRREMLPLVSSHRTRIFEAIMAGKPEEAREASHRHLAFIEEILLDRSREESRRERSLRRLEQRKN
What is the function of this protein?
Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.
What are the official names of this protein?
Pyruvate dehydrogenase complex repressor.
Protein: CDD_ECOL5
Sequence: MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLAAACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLPDAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHNIDRVLLA
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: COX16_YEAST
Sequence: MSFSGKKFRSRRQQLVYEASLAGRYKKALSKHPFLFFGLPFCATIVLGSFWLSSFTAIKYEQGDRKVQEINEEDILKIRKNQREFDIKEEYYRLQGLSEEDWEPVRVARLKDESENVW
What is the function of this protein?
Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:12446688, PubMed:28821616).  May participate in merging the COX1 and COX2 assembly lines (PubMed:28821616).
What are the official names of this protein?
Cytochrome c oxidase assembly protein COX16, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the COX16 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: RS19_DESPS
Sequence: MSRSIKKGPFIDDHLQKKVDQSLESGSRKVIKTWSRRSDISPEMVGLTFAVHNGKKFIPVFVSENMVGHKLGEFSPTRTYYGHSADKKGKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: ATG18_CHAGB
Sequence: MADLSNTKLNYVTFNQDHSCLAVATSRGFRIYHTDPFSKIFNSDEGNVTIIEMLFSTSLVAMVRSPRHLVIQNTKRGSIICDLTFPTAVLAVRLNRKTLAVVLEEEIYVYDIGNMALKHTIATSPNPNAIFALSPMSDRSYIAYPMPKPREDQGERRPAHAPPLSEYVPPTSGALMVFDTTAGKAVNVIEAHKMPLCCIALNHEGTKVATASERGTIVRVHSVPEGHKLFEFRRGTIPSTIYNMSFNLSSTLLCVSSSSETVHIFRLASAQNANAGGAGPAALETPGSPRANRWSRSKSIDGSEYSPSGDSDSSPRGETPEAGPSGPSAARRQSGTFGSMLRRSSQIVSRSVAGAVVPYLPQSVAEMWEPQRDFASVKIPKPTNAGDALLGPCL
What is the function of this protein?
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Necessary for proper vacuole morphology.  Plays an important role in osmotically-induced vacuole fragmentation.  Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy.  Involved in correct ATG9 trafficking to the pre-autophagosomal structure.  Might also be involved in premeiotic DNA replication (By similarity).
What are the official names of this protein?
Autophagy-related protein 18.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.
Protein: RS4E_IGNH4
Sequence: MARVGGGKRHLKRLAAPAFWPIHRKEAVWAVKPRPGPHPIEESIPLLILVRDVLGYAETSREARKLIAEGRIKVDGRVRKDYKFPVGAMDVIEIVGADEYYRMIPYPVKYLVPMRIDAEEAKKKICRIENKVTVKGGHVQLNLHDGRNVLIRVEDPRNPVEAQEYKTLGGLLITVPEQEILDYVPFEEGVIAIVKSGRNVGRVGRIEEIVKGMGRKKTLVKMRDVHDEVFYTVAEYVFPIGKEEPLIKLPEGAWK
What are the official names of this protein?
30S ribosomal protein S4e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS4 family.
Protein: AROE_LEPBL
Sequence: MNSKTNQTAKTFGIVGFPLSHSLSPLIHNSIYKDRGIDASYLVFETPELNSKTIQEFRNSGILGLSVTIPHKEKAFLLADKADSTSTIMKASNTLLIGPDSIHAYNTDGEGAYRSILELSPESLNVGNTVILGSGGSARGIAYNLAASGKIQNLFLCSRNEMTAKEICFLISKNSNVKMEHITQDSLFSRKEEISLVIHTTPLGMKGQAPGPFLSEKFFNPNMTLFDIVYNPLETPLVKAAKKAGAKIIPGSEMLLHQAMKQFELFTGISPNASDILKTRERLSQTLTNQ
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: LCK3_RHYMA
Sequence: DQGFNSWG
What is the function of this protein?
This cephalomyotropic peptide stimulates contractile activity of cockroach protodeum (hindgut).
What are the official names of this protein?
Leucokinin-3, Leucokinin III, L-III.
What are the subcellular locations of this protein?
Secreted.
Protein: X_HBVC8
Sequence: MAARVCCQLDPARDVLCLRPVGAESRGRPVSGPFGPLPSPSSSAVPADHGAHLSLRGLPVCAFSSAEPCALRLTSARRMETTVNAHQVLPKVLHKRTLGLSAMSTTDLEAYFKDCLFKDWEELGEEIRLKVWRL
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: GET3C_ARATH
Sequence: MAALLLLNRVSRSTSSISLHRVAGTLGFNSFNAQIHGDRISGTLFRVRSLATLAEGASHFNEMVSVNQRKYYLLGGKGGVGKTSCAASLAVKFASHGHPTIVVSTDPAHSLSDSFSQDLSGGVLKPVQGVDSPLLALEITPEIMKDEIKRQTGDKSVKNMMDSMGLGMFAGELGDLNLEDMLNAASPGIDEIAAISKVLQFMEAPEYSRFTRIVFDTAPTGHTLRLLSLPDFYDSSISKITKLKKKITAAASAFKLVFGKKEIQQKELPNELDQLKERMEKVRNVFRDVDTTEFVIVTIPTVMAINESSRLHASLRKENVPVHRLIVNQLLPQSESDCKFCSIRRKEQTRVLGLIQNDTELSGLKLIQSPLLDAEIRGVPALKFMGDLIWK
What are the official names of this protein?
ATPase GET3C, AtGET3C, Guided entry of tail-anchored proteins 3 homolog C.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: NFYB7_ARATH
Sequence: MTEESPEEDHGSPGVAETNPGSPSSKTNNNNNNNKEQDRFLPIANVGRIMKKVLPGNGKISKDAKETVQECVSEFISFVTGEASDKCQREKRKTINGDDIIWAITTLGFEDYVAPLKVYLCKYRDTEGEKVNSPKQQQQRQQQQQIQQQNHHNYQFQEQDQNNNNMSCTSYISHHHPSPFLPVDHQPFPNIAFSPKSLQKQFPQQHDNNIDSIHW
What is the function of this protein?
Component of the NF-Y/HAP transcription factor complex (By similarity).  The NF-Y complex stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters (By similarity).
What are the official names of this protein?
Nuclear transcription factor Y subunit B-7, AtNF-YB-7, AtNF-YB7.
What is the protein family that this protein belongs to?
Belongs to the NFYB/HAP3 subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNTR_GEOKA
Sequence: MPTPSMEDYIEQIYILIEEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLVYEKYRGLVLTPKGRKIGQRLVYRHELLEQFLRLIGVSEENIYRDVEGIEHHLSWNAIDRIGDLVQYFQEDERRLEALRDVQKRNEQGE
What is the function of this protein?
Central regulator of manganese homeostasis.
What are the official names of this protein?
HTH-type transcriptional regulator MntR, Manganese transport regulator.
What is the protein family that this protein belongs to?
Belongs to the DtxR/MntR family.
What are the subcellular locations of this protein?
Cytoplasm.