PharMolix/UniProtQA huggingface dataset:
Protein: PRCA_TRIV2
Sequence: MVHVRYGGQNGEQYELAISENHIVVRTESRSSLISDRPFEAAPVSPQARNILNQFELSTRFSQAGVEVLHVKEPSHDGALRDTAREILNQEPEVQFAGRVLIDPVSQQPIVYTENLFVKFDHEEDVSFCQEILGRYGLTIKRQLEYARNAYFVSAPSNTGLAIFDISERLLNEESVELCHPELVREFRQRQAFPPQWHLKQTTIGGKTINAHANVEAAWKLSDGTGTIIAIIDDGVDIDHEEFRSSGKIVAPRDVTRKTNFPTPGNRDNHGTACAGVACGNGNFGASGVAPGAKLMPIRFVSALGSQDEADSFVWAAQNGADVISCSWGPPDGTWWDDKDPLHKQKVPLPDSTRLAMDYAINKGRNGKGCVILFAAGNGNESVDNDGYASYEKVIAVAACNDFGTRSAYSDFGTAVWCAFPSNNGNPSQTPGIWTADRTGVVGYNSGNTNLGDQAGNYTNSFGGTSSACPGAAGVAALILSRNPNLRWDEVRDIIKRSCDRIDPVGGNYNAEGRSPFYGYGRINALKAVELALPAQPEPVSIFTAVQDVPINDLQISQLSLAIANTNPIKSIKVTVDIEHTYIGDLVVSLNPPAESGVLPIILHDRKGGGADDIKQTYDEVSTPGLTALKGKIPQGTWTLEVADKAQADTGKIRSLTIELGF
What is the function of this protein?
Degrades phycobiliproteins in vitro.  Has a substrate specificity similar to that of trypsin.
What are the official names of this protein?
Calcium-dependent protease, Trypsin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_GEOMG
Sequence: MELNNLKPAIGATKDRKRIGRGTGSGHGKTATKGHKGQKARSGGSIKAGFEGGQMPMQRRLPKRGFTPLMRKDYAIVNIGQLDVFESGSTVDAEALLNAGLISGVKDGIKVLADGDVTKSLVVKVHKYSAKAKEKIEAVGGKIEEITL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: MQO_PROM9
Sequence: MTSSKNPTNDNSYFDAVLVGAGIMSSTLALLISEVLPDIKFLIIEKLKAPGSESTGAFNNAGTGHAANCELNYTPLDEKGNLKIDKALSINRSFERSMSLWASLYESGKIDIKKFLKFIPHISFVSGQDNISFLKKRFQKMTDNPEFIDMEFSTSFDEISSWAPLITKDRNPSTQIAATRIGRGTDINFEALTKEYLSLVSLNKNVEIRYKTELVDLKKIDKKQWELEISSEGRKTSIRTGYVFLGAGGKTINYLQKSKIPEAKSYGGFPVSGKWLICEKKDLTEKHNSKVYGKADIGSPPMSVPHLDTRWIDNKKLLLYGPFAGFTTKFLKQSSYFDLFSSIKKNNIFSMLDVGFKNNDLINYLISQSLKNHNSRVDNLKNMMPSANPSDWYLKNAGQRVQIIKKTEGGGSLKFGTEIVNSSDGSLSALLGASPGASTAVSIMVEVLEKSVLLLNDKHNLQKKINDLIYPELSDSENKSIYIKDIKKRNNSIFGFHP
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: MURA1_STRT2
Sequence: MDKIIVKGGNTRLSGEVVIEGAKNAVLPLLAATILASEGQTTLTNVPILSDVYTMNNVVRGLDIAVDFNEENNTVVVDASGEILDQAPYEYVSKMRASIVVLGPILARNGHAKVSMPGGCTIGSRPIDLHLKGLEAMGAKIIQVGGDITATAEKLKGATIYMDFPSVGATQNLMMAATLADGVTTIENAAREPEIVDLAILLNEMGANVKGAGTEKLVIKGVKSLHGTQHAVIQDRIEAGTFMVAAAMTSGNVLIKDAIWEHNRPLISKLLEMGVDVKEEDRGIRVKSDVSKLKPVAVKTLPHPGFPTDMQAQFTALMAVVKGKSSISETVFENRFQHLEEMRRMGLHSEILRDTAMIHGGLPLQGARVMSTDLRASAALILTGMVAEGTTTVGKLTHLDRGYYKFHEKLAKLGAQISRVSEA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, Enoylpyruvate transferase 1, UDP-N-acetylglucosamine enolpyruvyl transferase 1, EPT 1.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSHC_STAHJ
Sequence: MDCRVTHFKEKDSFISKLKESDKSLLEFYQYNPVETASFTTKMKRPNNGREKQLAQIIKDYMADLKLTTSQLEHIEALEQGAKVVIGGQQAGLFGGPLYTFHKILSIVTLSSQLTKEYGETVVPVFWIAGEDHDFDEVNHTYVYNAKEAQLKKVKYHTMTPPETNVSRYTPDKEAMLNALNLFFEELKETNHSKPLYKLCVDIINEFDTWTDIFKALLHAVFKEHGVLLIDAQNDKLRQLEKPLLKQIVTNHSKINQVFRQTQEQTIASGLTQMIQTDTNVHLFLHEDGMRQLISKEDNLFKLSKSDITYSEEELIELIETEPERFSNNVVTRPVMEEWLFNTVAFIGGPSEIKYWAELNNVFKLLNVEMPIVLPRMKMTYMMERTQKLLKQYSLNVEKVIQNGIDDDKNEFVREKASDTFIQQVEELKAKHENVYQQLLNEVKENQDNFNLVTKNEEIHNKQFDYLLKRYLLNIERENDISMRQFRELDLVLHPHHGLQERIWNPLQIMNDFGIDVFSPSTFPPLEYTFDQIIIKP
What is the function of this protein?
Involved in bacillithiol (BSH) biosynthesis.  May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.
What are the official names of this protein?
Putative cysteine ligase BshC.
What is the protein family that this protein belongs to?
Belongs to the BshC family.
Protein: PROA_PSEPW
Sequence: MTESVLDYMTRLGRAARQASRVIARASTAQKNRALQAAADALDAARAELAAANEQDLAAGRANGLEPALLDRLALTPARIDGMITGLRQVASLPDPVGAIRDMSYRPSGIQVGKMRVPLGVIGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRAIATCIQRGLAEAGLPAAVVQVVETTDREAVGALISMPEFVDVIVPRGGRGLIERISRDARVPVIKHLDGICHVYVAEHADLDKGWRVAFNAKTYRYGICGAMETLLVDQRVAEGFLPEMARRFQEKGVELRGCERTRALIEAKPASEDDWHTEYLDAILSIRVVDGLDQAIEHINHYGSHHTDSIITEHQGQARQFMAEVDSASVMLNTPTCFADGFEYGLGAEIGISTDKLHARGPVGLEGLTCEKYVVIGDGQLRGQESC
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WNT5A_MELGA
Sequence: SGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLVQMNSRFNAPTIHDLIYIDPSPDYCMRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVERERCNCKF
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Can activate or inhibit canonical Wnt signaling, depending on receptor context.  Required during embryogenesis for extension of the primary anterior-posterior axis.
What are the official names of this protein?
Protein Wnt-5a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: PATA_PENEN
Sequence: MKLSAEGTVMASSEEAAQLSCDTSSSHARNSKEQDFQPTQQIGSPTALGMGAFAIAFTTLSMSLMEWRSAAITNAYIGNCFFTAGMGLVLVAQWELVRGNSFGHTVFGGFGLFNLAFGAINAPAFGVADAFKDDPAALNNAIGYFLLVWGIFVLFFTVAAMPMNLVYTGMLGTSQITYTLLAASYFSFADDHASAGLALKKAAGAFGFVSGLFAWYTVGHLMCQDALLFSFPLGDTSPLYARLQRKKRH
What is the function of this protein?
Acetate transporter protein; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25120234, PubMed:30100914, PubMed:25625822, PubMed:30680886).  May be involved in the uptake of acetate, a substrate for the synthesis of 6-methylsalicylic acid by the polyketide synthase patK (By similarity).
What are the official names of this protein?
Acetate transporter protein patA, Patulin biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DLEC1_MOUSE
Sequence: MDSESKEEQQCTASSAVMSSLETQFLSVPHQLESASLSWSIRKSLHSSTVLMDDCHFGFPTRSLRAGFHALPPLPEPQTLRLRPASLRTQEISHLLARVFRNLYTAQVIGDDLSDSLIKARGSEDARHEEFLDQLQQARAIYKQRLDEAAMLERHIMQARARDIAETEHTTKQSRLQVVETPVKLPPVKTAFRWCLDSKLMRKHHLISTEDYYTDPVPFCPAPKDKSTLGCSKLTFSCEQRFLRKSELDREAEEHCRQLTECDDFEYTVDSLGSISKAKERTTDSVKKTSRPKNKKWMEHLQVPQRALDRRLLASMENRNHFLKNPRFFPPNTPHGGKSLIVPLSKPERRASLNAEPEWSCTDAPVFLAKPSVGFFTDYEIGPVYEMVIALQNTTSTSRFLRVLPPSSPYFALGLGMFPGKGGIVAPGMTCQYIVQFIPDCLGDFDDFILVETQSPHTLVIPLQARRPPPVLTLSPVLDCGHCLIGGVKITKFICKNVGFSVGKFCIMPQKSWPPPSFRAVATTGFVEQPPFGVMPSVFELAPGYAILLEVLFLPTGLGQAEETFIIVCDNCQIKEVVVVGTGQLVALDLIHISGGKNEPDPGELKDLTAQYFIRFEPENVQSTPKKQLIIRNAT
What is the function of this protein?
Essential for spermatogenesis and male fertility (PubMed:33144677).  May play an important role in sperm head and tail formation (PubMed:33144677).  May act as a tumor suppressor by inhibiting cell proliferation (By similarity).
What are the official names of this protein?
Deleted in lung and esophageal cancer protein 1 homolog.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMO_CHLT3
Sequence: METKRSKLYLLTLGCSKNMVDSEVLLAQAKANQIYLAEDFHEADTILINTCGFIDKSKQESIDQILEAIRFKEAKRIKKVIVFGCLSERYKDALREEIPEVDCYFGTRDLSQIIAELGGHYKTHLLGERELLTPPYFSYLKISEGCDHPCAFCAIPLMRGKQVSRPIDELLLEAKKLKEKGVRELCLIAQDTTYYGHDLNGKRQLAELLQRLSDLQFDWIRLLYAYPAMFPTDILPVMRERENICKYLDLPLQHVSDEMLKSMRRGISKRKTTELIAQIRSEVPGIRLRTTMLVGYPNETEEQFSELVEFVRETQFDRLGCFAYSHEEGTEAHELPDTLTEEEKERRVELLMAAQEEIAYAKNQALVGSFMPVLIERFEANFAIGRTEYDAPEVDNEVVIALDEAEQKKVKVGTFYQARITDAEAFDLFGSLVL
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEOC_SALHS
Sequence: MASLIQVRDLLALRGRMEATQISHTLHAPQPMIDAMLNQLEIMGKAVRIPEEPDGCLSGSCKSCPEGKACLREWWALR
What is the function of this protein?
May function as a transcriptional regulator that controls feoABC expression.
What are the official names of this protein?
Probable [Fe-S]-dependent transcriptional repressor.
What is the protein family that this protein belongs to?
Belongs to the FeoC family.
Protein: MAEL_DROSE
Sequence: MAPKKQNGFMMFVNEWRNRNAEGRRMTLAEAVYHCGTIWEKMDTQQRGPYNSDAKDANAARRDKRGSLNGHGQVDKAQREAAESLMDKAQREAAESLMDMKRTTERLVLNAKMSHDLENAKFVFVAFNYFTKALTTDVYVPAEFAACEYSLKEGIRSIYSTMIDPGQIIFGQGSDALHNSSTTHDLPLPPNALGEKNMAKLYHNILDYLTKCQGEGKTPIVFTPAENIGMVKSCFRYLECEDDSRDGSGKIEVFDIQYLLFILKKEVMSVAGLNDEKINKFATDAFFKNDFFEFTAGIACQISSINTRDYHVATLIGLLPAQTINVYLGSTLRSMHEVLSDNDTKLTGYISFLFEVICGVALMFWVLQKARKELSETLLSADYNNEGKHPDVQV
What is the function of this protein?
Involved both in the piRNA and miRNA metabolic processes.  As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons.  As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam).  Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
What are the official names of this protein?
Protein maelstrom.
What is the protein family that this protein belongs to?
Belongs to the maelstrom family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein: GLYA_HISS2
Sequence: MLKRSMNIADYDPVLWQAIQDENLRQEEHIELIASENYASPRVMEAQGCQFTNKYAEGYPGKRYYGGCEYADIVEQLAIDRAKALFGADYANVQPHSGSQANAAVYMALLNPGDTILGMSLAHGGHLTHGASVSFSGKIYKAEQYGITSEGLIDYDALRKQAHEVKPKMIVGGFSAYSQIVDWAKMREIADEVGAYLFVDMAHVAGLIAAGVYPSPMPHAHVVTTTTHKTLAGPRGGLILANGNEELYKKLNSAVFPAGQGGPLVHVIAAKAVCFKEALEPEFKTYQAQVVKNAKAMVKVFKQRGYNVVSNGTENHLFLVDLVNHGLTGKAADAALSRANITVNKNAVPNDPQKPFVTSGIRVGTPAVTRRGFNEEDVAELAGWMCDILDSMNKDNHEQVIADTKEKVLAICKRLPVYP
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PD_MAIZE
Sequence: XGRNEFVIRLQXSEA
What is the function of this protein?
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.  The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform, G6PD, 2D-page of etiolated coleoptile spot 243.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAFA_FRASN
Sequence: MDRRIFGLENEYGVTCVFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLKNGARLYLDVGSHPEYATPECDSVPDLVTHDKAGERILEGLLVEAERRLREEGIAGDIHLFKNNTDSAGNSYGCHENYLVGRHGEFSRLADVLVPFLVSRQILCGAGKVLQTPRGAVYCISQRAEHIWESVSSATTRSRPIINTRDEPHADAERFRRLHVIVGDSNMSETTMLLKLGSTDLVLRMIEAGVVLRDMSLENPIRAIREVSHDMTCQRRIKLANGREVSALDIQREYYSKAVEFVERRGGDAVAKRVLDLWGRTLLAIETEDLELVAREIDWVTKFVLIDRFRLKHGLSLASPRVAELDLKYHDIHRDRGLYYRMERAGLVERVTRDLDIFEAKSVPPQTTRARLRGEFIKRAQEKRRDFTVDWVHLKLNDQAQRTVLCKDPFRSVDDRVDKLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: ATPE_THEYD
Sequence: MENKLKLEVITPYGEVINEEVDEVYTTGAEGDFGVFPGHCAFMTAIRIGSLSYKKDGQMHYLFVNRGYCEVLNDRVLVLVGSAERVEEIDVERAKAALARAEERLRKAQAGETDIDLARAQAALERATIRIQLATKLIPR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: KDSB_HALHL
Sequence: MSTPAFTVVIPARYGASRLPGKPLADLLGEPVVQHVYRRAVESGAARVVVATDDARIESACRDFGAEVLLTAPDHPTGTDRIAEVVDRLALVDEAIVVNLQGDEPLMPPELVALVAERLDTDPDAAIATLATPVTAADELFEPSVVKVVRDHRDHALYFSRAPVPWDRDRFDGIDDGAVAAGGWLRHLGLYAYRAAFLRRFPGLEPAPPERLESLEQLRALWHGFAIQVAATDQRPGPGVDTPADLEAVARRLQSTR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAIA_ECOLU
Sequence: MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEHGGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMWNSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVYTEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHERFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEAAWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVSGGSDEMQILTLGRAVLKQYR
What is the function of this protein?
Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
What are the official names of this protein?
Crotonobetainyl-CoA reductase, Crotonobetainyl-CoA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEN2_HUMAN
Sequence: MAEAVFHAPKRKRRVYETYESPLPIPFGQDHGPLKEFKIFRAEMINNNVIVRNAEDIEQLYGKGYFGKGILSRSRPSFTISDPKLVAKWKDMKTNMPIITSKRYQHSVEWAAELMRRQGQDESTVRRILKDYTKPLEHPPVKRNEEAQVHDKLNSGMVSNMEGTAGGERPSVVNGDSGKSGGVGDPREPLGCLQEGSGCHPTTESFEKSVREDASPLPHVCCCKQDALILQRGLHHEDGSQHIGLLHPGDRGPDHEYVLVEEAECAMSEREAAPNEELVQRNRLICRRNPYRIFEYLQLSLEEAFFLVYALGCLSIYYEKEPLTIVKLWKAFTVVQPTFRTTYMAYHYFRSKGWVPKVGLKYGTDLLLYRKGPPFYHASYSVIIELVDDHFEGSLRRPLSWKSLAALSRVSVNVSKELMLCYLIKPSTMTDKEMESPECMKRIKVQEVILSRWVSSRERSDQDDL
What is the function of this protein?
Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA.  It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini.  There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.  Isoform 1 probably carries the active site for 5'-splice site cleavage.  The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.  Isoform 2 is responsible for processing a yet unknown RNA substrate.  The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
What are the official names of this protein?
tRNA-splicing endonuclease subunit Sen2, tRNA-intron endonuclease Sen2, HsSen2.
What is the protein family that this protein belongs to?
Belongs to the tRNA-intron endonuclease family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.
Protein: ROCK2_BOVIN
Sequence: MSRPPPTGKMPGAPEAVSGDGAGASRQRKLEALIRDPRSPINVESLLDGLNPLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCKENDSIQSRKNEESQEIQKKLYTLEEHLSTEIQAKEELEQKCKSVNTRLEKVAKELEEEITLRKNVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSVLESERRDRTHGSEIINDLQGRISGLEEDVKNGKILLAKVELEKRQLQERFTDLEKEKNNMEIDMTYQLKVIQQSLEQEETEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLSEERTLKQKVENLLLEAEKRCSILDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLLEMKMSLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKEAQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDTEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS
What is the function of this protein?
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.  Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM.  Phosphorylates SORL1 and IRF4.  Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation.  Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation.  Plays an important role in the timely initiation of centrosome duplication.  Inhibits keratinocyte terminal differentiation.  May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles.  Plays a critical role in the regulation of spine and synaptic properties in the hippocampus.  Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
What are the official names of this protein?
Rho-associated protein kinase 2, Rho-associated, coiled-coil-containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, ROCK-II, p164 ROCK-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane.
Protein: SERF1_HUMAN
Sequence: MARGNQRELARQKNMKKTQEISKGKRKEDSLTASQRKQSSGGQKSESKMSAGPHLPLKAPRENPCFPLPAAGGSRYYLAYGSITPISAFVFVVFFSVFFPSFYEDFCCWI
What is the function of this protein?
Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760, PubMed:22854022, PubMed:31034892).  Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (PubMed:20723760, PubMed:22854022, PubMed:31034892).
What are the official names of this protein?
Small EDRK-rich factor 1, Protein 4F5, h4F5, SMA modifier 1.
What is the protein family that this protein belongs to?
Belongs to the SERF family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: FBX40_HUMAN
Sequence: MGKARRSPPGHHRHCEGCFNRHCHIPVEPNTSCLVISCHLLCGATFHMCKEAEHQLLCPLEQVPCLNSEYGCPLSMSRHKLAKHLQVCPASVVCCSMEWNRWPNVDSETTLHENIMKETPSEECLDTALALQDQKVLFRSLKMVELFPETREATEEEPTMNGETSVEEMGGAVGGVDIGLVPHGLSATNGEMAELSQEEREVLAKTKEGMDLVKFGQWENIFSKEHAASALTNSSASCESKNKNDSEKEQISSGHNMVEGEGAPKKKEPQENQKQQDVRTAMETTGLAPWQDGVLERLKTAVDAKDYNMYLVHNGRMLIHFGQMPACTPKERDFVYGKLEAQEVKTVYTFKVPVSYCGKRARLGDAMLSCKPSEHKAVDTSDLGITVEDLPKSDLIKTTLQCALERELKGHVISESRSIDGLFMDFATQTYNFEPEQFSSGTVLADLTAATPGGLHVELHSECVTRRHNKSSSAFTFTCNKFFRRDEFPLHFKNVHTDIQSCLNGWFQHRCPLAYLGCTFVQNHFRPPGQKAKVIYSQELKTFAIKPEVAPELSEGRKNNHLLGHGGKSQNSLTSLPLEILKYIAGFLDSVSLAQLSQVSVLMRNICATLLQERGMVLLQWKKKRYSHGGTSWRVHREIWQFSSLFSKIKSWEFNEVTSMSEHLKSCPFNIVEHKTDPILLTSMCQPREQARESLVSTFRIRPRGRYVS
What is the function of this protein?
Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.
What are the official names of this protein?
F-box only protein 40, Muscle disease-related protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MANC_PIRSP
Sequence: MLTLTLLLYLSFITTVFSKKVIYEAENGKLDGVSKYNELQGYSGTGYVGRFESAGNSVTVTVEVSQTGMYDMSIIYCGNMGQKINSLKINGKNSGDITFPENSSFEELNIGAVYLNSGENTVSLVASWGWIWIDALVVNDTPNVAKDVSPHINPTLVNPKAIPAAKKLYDFLRSNYGKRILSGQVGGAGQAGDEGQEIQRIQKATGKLPAVWNMDFIFESNDCTWRPENPDITEMAINWWKKYQGKGIMAAQWHWNIAGKTGDFAFYKKDTTFSIDNAVTEGTWEYEKIIKDIDRVAGHIKKLQAVNMPLIWRPLHENDGDWFWWGNNPKSCAKLWKILYERMVNYHGLNNLIWLWNGKNDANTPVDYIDIIGVDIYANDHGPQTTAYNTHFDFYGGKKMVVLSENGRIPDIQQCVDQNAWWGYFQTWNSEFILQDSYHTDAQLKEYFTHKTVMNMDELPSFNVNSYEYQSGNNNNNSSNNNNNNNSSECFSIPLGYPCCKGNTVVYTDNDGDWGVENNEWCGIGNSSSAVVCWSEALGYPCCVSSSDVYYTDNDGEWGVENGDWCGII
What are the official names of this protein?
Mannan endo-1,4-beta-mannosidase C, 1,4-beta-D-mannan mannanohydrolase C, Beta-mannanase C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 26 family.