PharMolix/UniProtQA huggingface dataset:
Protein: ISM1_MOUSE
Sequence: MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQRSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY
What is the function of this protein?
Acts as an angiogenesis inhibitor.
What are the official names of this protein?
Isthmin-1.
What is the protein family that this protein belongs to?
Belongs to the isthmin family.
What are the subcellular locations of this protein?
Secreted.
Protein: DSBD_ECOL6
Sequence: MAQRIFTLILLLCSTSVFAGLFDAPGRSQFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNEASQPVSVPQQEQPTAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTRLTLMSNRQQGGSPGGVFIMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGTLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPVFLLERVIGDIWGLRLWSALGVAFFGWAFITSLQAKRGWMRVVQIILLAAALVSVRPLQDWAFGATHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKEFEKYTFSDPQVQKALADTVLLQANVTANDAQDMALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDRQP
What is the function of this protein?
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes.  Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm.  This transfer involves a cascade of disulfide bond formation and reduction steps.
What are the official names of this protein?
Thiol:disulfide interchange protein DsbD, Protein-disulfide reductase, Disulfide reductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SHG1_YEAST
Sequence: MAYNQEDSKRLSDKYKKEGHFDKLKREILSNPWNNTEENSESFEQALRKRVASTVKEMVNEDEELIFKNRGLTSALIESQLVKDNYLKLGSKMEGDNGDGEKKFDLDVYVRSKLQDPKLLEMIKGQLQETLNSYEEEANGST
What is the function of this protein?
The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
What are the official names of this protein?
COMPASS component SHG1, Complex proteins associated with SET1 protein SHG1, Set1C component SHG1.
What is the protein family that this protein belongs to?
Belongs to the SHG1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYML2_MELLF
Sequence: GKPTCGETCFKGKCYTPGCTCSYPLCKKD
What is the function of this protein?
Probably participates in a plant defense mechanism (Potential).  Binds to and induces leakage in phospholipd membranes, particularly ones containing 1-palmitoyl-2-oleophosphatidylethanolamine (POPE) (PubMed:26322745).  In vitro, displays cytotoxicity against cultured cells but no hemolytic activity towards fresh erythrocytes (PubMed:26322745).  Not active against Gram-negative bacterium E. coli ATCC 25922 or Gram-positive bacterium S. aureus ATCC 25923 up to a concentration of 64 uM (PubMed:26322745).
What are the official names of this protein?
Cyclotide mela-2.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Moebuis subfamily.
Protein: CLPP2_CORGL
Sequence: MTVFMSDIRMAAQGGPGFGNDVFDRLLSERIIFLGSQVDDEIANKLCAQILLLSAEDPTRDISLYINSPGGSVTAGMAIYDTMKYSPCDIATYGMGLAASMGQFLLSGGTKGKRFALPHARIMMHQPSAGVGGTAADIAIQAEQFAATKREMAQLIAEHTGQTFEQISKDSDRDRWFTAQEAKDYGLVDHVITLAEGPISN
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 2, Endopeptidase Clp 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_SORAL
Sequence: MTNLRKTHPLMKIVNSSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLFLHVGRGLYYGSYMYLETWNIGVLLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSDLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAGVHLLFLHETGSNNPSGLSSDADKIPFHPYYTIKDILGVLLLILTLTSLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILAVVPFLHTSKQRSMMFRPFSQCLFWILVADLLTLTWIGGQPVEHPFIIIGQLASILYFLLILVIMPITSLFENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: NUSB_RHIME
Sequence: MTNTPSDQPLKQVNQRGAARLAAVQALYQMDVGGTGVLEIVAEYEEHRLGKELDGDTYLRADASWFRSIVAGVVRDQRKLDPLIGSALQDDWALSRLDSTVRAILRAGTFEILERKDVPVPVIVTEYVEIAKAFFQDEEPKLVNAVLDRIAKQVRGDQRK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: QUEA_STAAW
Sequence: MNIEEFDYDLPESLIAQTPLKDRDHSRLLVMDRETGEMKHLHFKDIIEYFRPGDTLVLNDTRVMPARLFGLKEETGAKVEMLMLTQIEGNDWEVLLKPAKRIKVGNKLNFGNGKIIAECIKEMDQGGRIMRLHYEGILQERLDELGEMPLPPYIKERLDDPDRYQTVYAKESGSAAAPTAGLHFTDELLTEIKNKGVNIAFVTLHVGLGTFRPVSVDDVNDHEMHSEYYQMTQETADLLNDTKSKGHRIISVGTTSTRTLETIRRDHDKFVETSGWTNIFIYPGFDFKAIDGQITNFHLPKSTLVMLVSAFSTRENVLNAYKTAVNLEYRFFSFGDAMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A1IA6_LOXHI
Sequence: WIMGHMVNAIYQIDEFVNLGANSIETDVSFDDNANPEYTYHGIPCDCGRSCLKWENYNDFLKGLRSATTPGNSKYQSKLILVVFDLKTGSLYDNQASEAGKKLAKNLLKHYWNNGNNGGGAYIVLSIPDLNHYPLIKGFTDTLKQEGHPELLEKVGYDFSGNDAVGDVAKAYKKAGVSGHVWQSDGITNCLLRGLTRVKEAVANRDSGNGYINKVYYWTVDKRATTRDALDAGVDGVMTNYPDVIADVMNEAAYKNKVRLATYEDSPWVTFKK
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LhSicTox-alphaIA2avi, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOB_LARHH
Sequence: MGIEGVLEKGFITTSADKVLNWTRTGSLWPMTFGLACCAVEMMHAGASRYDLDRFGIVFRPSPRQSDLMIVAGTLCNKMAPALRKVYDQMAEPRWVLSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALLYGIIQLQNKIKRTCTIAR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL35_CAUSK
Sequence: MPKLKTKSGAKKRFKITATGLLKAGVAGKRHRLIGHNGKYIRQNRGTKVMSASDTKTIRSYMPYGL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: TIFAB_RAT
Sequence: MERPLTVLQVSLYHPTQGPVAFAKVPLQLQHDASRLLVGRGQDTHLQLQLPQLSRHHLCLEPYLEKGSNLLAFCLKVLTRQSCVWVNGLPLRYLEQVPLHSVNRISFSGIQMLIRKEGGASLEAFVCYFHLSPSPLIYRPKAQETDE
What is the function of this protein?
Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.
What are the official names of this protein?
TRAF-interacting protein with FHA domain-containing protein B, TIFA-like protein.
Protein: DNLJ_CORA7
Sequence: MSDAVDIQREWSELAQEVRKHRELYYNGEPSIPDADFDELFQRLLALEAEHPELQTPDSPTQQVGAAPEGAVDIEHLERLYSLDNVFSAEELQDWLDRTPAEAYLTELKIDGLSIDLVYRDGKLVTAATRGDGRVGEDITANARVIPDIPHELTGTDEYPVPSLVEVRGEVYMRPDEFEEINAARREDGKPTFANPRNAAAGGLRMKDPEDVKKRRLHMVCHGIGARERFQPTSQHDAYKALEAWGFPVSPYTQRVTTAKEVQERVTYWEEHRHDAYFEMDGLVIKVDDLASQRALGATSRAPRWAIAYKYPPEEVTTKLLNIEVGVGRTGRVTPFAIMEPVFVSGSTVSMATLHNQFEVKNKNVLIGDTIIIRKAGEIIPEVLGPVLDKRDGSETEWVFPENCPACGTKLAPQKEGDQDWRCPNTRSCPAQLAARLEYLASRKALDIGELGEKAAADLISSGVLEDEADLFDLDEQALLKSSVYTTQKGALNASGKKLLENLKTARQAEFWRVLVALSIRHVGPIAARALATRFGSMEVLRAASVEELADTDGVGTIIAESFKQWFEVDWHDNIVQKWTAAGVTMEEESSDKPAQTLEGITVVVTGTLENFTRDSAKEAIITRGGKASSSVSKKTNYVVVGENAGSKEQKARDLGLTILDEEGFTRLLETGEA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PAND_BURPS
Sequence: MQRHMLKSKIHRAAVTHCELHYEGSCAIDEDLLEAANIVENERIDIWNVNNGERFSTYAIKGERGSGMISLNGSAARRAQLGDLVIIAAFAMIDEQELKAGWKPDLVFVDEDNKIKGSRDHVPTQNWT
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_SALTY
Sequence: MSSYENHQALDGLTLGKSTDYRDNYDVSLLQGVPRSLNRDPLGLTADNLPFHGADIWTLYELSWLNSQGLPQVAVGHVELDYTSVNLIESKSFKLYLNSFNQTRFDTWETVRQTLERDLRACAQGNVSVRLHRLDELEGQPVAHFHGTCIDDQDISIDNYQFTTDYLQHAVSGEKQVEETLVSHLLKSNCLITHQPDWGSIQIQYRGRKIDREKLLRYLVSFRHHNEFHEQCVERIFNDILRFCQPETLSVYARYTRRGGLDINPWRSNTDFVPATGRLARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MT2_HUMAN
Sequence: MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGASDKCSCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
What are the official names of this protein?
Metallothionein-2, MT-2, Metallothionein-2A, Metallothionein-II, MT-II.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: YPFN_ECO45
Sequence: MDWLAKYWWILVIVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDDDDDWPKKDQPKK
What are the official names of this protein?
UPF0370 protein YpfN.
What is the protein family that this protein belongs to?
Belongs to the UPF0370 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: NOL6_DROMO
Sequence: MGRIKENQSKKKTLLRDSKAYSDQAAAAVTSSDDGFDEPKEITAPKRKLPCGNSDAKKKKFKHPEANVKPPTLEEIKEIRDTRNLFHSNLFKLQVKEMLEELQLKPKYSNYIENWLETFTTAVHEFQDGLLDNCQLEVPLHLHKKLFNFQFLTPTAEPKLIGAAAIGTLLGPKLVVDVALEMPEKCFQKEDYRNLIFDQKRALYLATVASKLKELPACAADHFAYNYHANNPLKPVLELTPTGKIGKHLSLRLYITAPKAIFKLSRFVPWNNNVRPSFFGDKWDESETLPSTQHYNANVLFDLTLAENQKLLLSTFSGHRNFQEGLLLLKVWLRQRQLDVGFSGFSAHILAAYIVYLKQNRLLHQSSSSYQVARTVWNQLANSDWTQGITLCPQQPHQLSTLAGYYDVCFMDVTGYYNICANLPLSVYKAVCAEAKLAVELLNDVRVNSFSQIFMQASPLYTRMDNILKITNPATVDQLLELHVQPQVKYDYANYAHPQLLKLLTDLLQKGLGKRVHAILPLETASKSWTVDTKAPIIGRSLTLGLILDPEHAFEVLDKGPATNEDAEGAAEFRKFWGEKSNLRRFQDGSITEAVVWAAVTDAPSKKRLIVRQIVLHLLEQHLQLEQSDVHYIAGELDIIYSLTSSFKVAKLQTKLKLEQETDAEAVTPLVIHCYDALARQLHTLGDLPLDIVSISGISPVFRYCEPQPLLPQARLVADRMHAGHVLRVIIQLGPSGKWPNELGALRSLKTAFLIQIGKQLKEQQHLHTQLCKEGLLVLKQGYCFLLELAHTKEVALLKQQQTERGVTAYVDNAASREIERRHYILPRVSGALHALHQSHSTFGPTVLIAKRWLATQMIDDGLWPSIATELLVAHLFQQRQMPHTTVAPQTGFIRFLQLLAHSDWASELFLLNFNNSWTEQQITDLEHSYRSERDSYPALCLATAYDQQHAGRLWTTDDCPSKPVLGRVTLLARHALQLIESSLLSPSLGFVRPAQLFIASGEGYDLVIELKPDLLPNTLCYDLGSPFLPFSQRNFRLPLAGIDQLAKIVQQLRSAYSEYAAFFYNPHGGKELAIVWRPASEFAPKPFKVNELQACTPCSVGKVQVVRDTLVEDFKLLLKDFYLRICTPEQLKREQRSHNKPKRYFDDQSEPDVDKPQKKKKKKGTVTKPTDLKKRLKKSKSLSALC
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
Nucleolar protein 6, Maternal transcript 89Ba.
What is the protein family that this protein belongs to?
Belongs to the NRAP family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RFT1_YEAST
Sequence: MAKKNSQLPSTSEQILERSTTGATFLMMGQLFTKLVTFILNNLLIRFLSPRIFGITAFLEFIQGTVLFFSRDAIRLSTLRISDSGNGIIDDDDEEEYQETHYKSKVLQTAVNFAYIPFWIGFPLSIGLIAWQYRNINAYFITLPFFRWSIFLIWLSIIVELLSEPFFIVNQFMLNYAARSRFESIAVTTGCIVNFIVVYAVQQSRYPMGVVTSDIDKEGIAILAFALGKLAHSITLLACYYWDYLKNFKPKKLFSTRLTKIKTRENNELKKGYPKSTSYFFQNDILQHFKKVYFQLCFKHLLTEGDKLIINSLCTVEEQGIYALLSNYGSLLTRLLFAPIEESLRLFLARLLSSHNPKNLKLSIEVLVNLTRFYIYLSLMIIVFGPANSSFLLQFLIGSKWSTTSVLDTIRVYCFYIPFLSLNGIFEAFFQSVATGDQILKHSYFMMAFSGIFLLNSWLLIEKLKLSIEGLILSNIINMVLRILYCGVFLNKFHRELFTDSSFFFNFKDFKTVIIAGSTICLLDWWFIGYVKNLQQFVVNVLFAMGLLALILVKERQTIQSFINKRAVSNSKDV
What is the function of this protein?
Involved in N-linked oligosaccharide assembly.  Required for the translocation of Man(5)GlcNAc(2)-PP-dolichol from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.
What are the official names of this protein?
Oligosaccharide translocation protein RFT1, Requiring fifty-three protein 1.
What is the protein family that this protein belongs to?
Belongs to the RFT1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DXR_RHOPB
Sequence: MSAVPLRNAKVAASGVRSVSVLGATGSIGDSTMDLLRASPERYQVEALTANTNVAGLAKLAREFNARFVAVADPARLSELRAALAGTGIACGAGDSAIVEAAERPADWVMAAVAGAAGLKPTLAAVDRGAHVALANKECLVCAGEFFMDRAAKAGATILPADSEHNALFQALASGNRDELTKVIITASGGPFRTWAAADIEQATLAQALKHPNWSMGQKITIDSASMMNKGLEVIEASWLFALSPDEIDVVVHPQSIIHGMVEFSDRSVVAQLGSPDMRTPIAHCLGWPDRIVGRAAPLDLAKIGTLTFEAPDYARFPGLKLAYEALRAGNGATTVYNAANEVAVAAFIAQRIRFGAIARLVEETMSSWIRAGNQAPLSCADDAIAVDHSARNMAAALLPQIAAKAS
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RIMP_DEIRA
Sequence: MNNKTNNNSVLFDLADGAVRPLGFEVLEVTQQREGRDLIVLVRIDRLDEQPVTMDDLTAASRAAEAEFDRVDPIEEEYRLEFESPGGKRPLLRARHFERMIGLKAKVRSLPGRGEHNFTAPIKAVEGDTVTFEHGGEDLSVNVADIQASLAEFPDRHR
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPG3_RICFE
Sequence: MYKKLYLIGILLLGLISGLTFNLIFFTVPYQLSEAKYTTDIIGSISLAAFPYCLKVIWSPFIDKYSIPFLCSKFGHRRGWALVSQIFLILAMTGFLNVSPCNNLYITAIILFIISFCSSTQDIVLDAYRIERPTSKEELSMAFTFSSIGFRLGMLLGSVGALYLSIIFGWNTVYKFALFITVVGPIVILCIKEPKPKEKRHTTTNLIGLQQYFEVIKKSIISLKNEQQYLLLIMLFVFLYKAADSIPMAMSSPLFLDLSFTTHEIAVIYKAYGLLIMIVGGALGGVLAAKMGIFHSVLIGGVIQLLSPLMFMILATIGYDIRIFIITVTVQNFCAGFAGTIISIYFASLCNSEFVATQYSIIASFSSLSRIILASLGGICAKYLTWPVFFLGNTLFSMLFIPIFYKIYRKKLDFVNISKKI
What are the official names of this protein?
Putative transporter AmpG 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: BORE1_XENLA
Sequence: MASGKKKTSRKPKNRSVKNEKLASFIKDFDSQVKIITEEMKASVVNILKEVDSQYNIEIIKLPMAIREMCWLDYIAKGGSQKALEAAATVKVDMEEITSTVTKTPFKADKKVKKGKCKPDDETVELNPLKSVIRTKTKAKVAAKKPSTARRTRASVGNVANTSKRTSKRGRATPSASKQAETSLLGYTPAATPRIDTSIFKTPALRTPCMQEPVYTFSANGSPLAGMDELFINVPARDGKIIRLLASEVDGLDINRLDQQAFENIKLLSSRLERLCKKLK
What is the function of this protein?
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.  The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.  Contributes to CPC function by facilitating loading of the CPC onto chromosomes.
What are the official names of this protein?
Borealin, Cell division cycle-associated protein 8, Dasra-B, DasraB, xDasraB.
What is the protein family that this protein belongs to?
Belongs to the borealin family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis.
Protein: LRC14_RAT
Sequence: MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTAVLRELVHTWPFPLLSFQQLLQECAHCSRALLQERLSTESMQAVILGLTARIHAREAEAGTQPVCRKHTLRVLDMTGLLDDGVEQDPGTMSMWDCTAAVARTCIAQQQVGTAKPGLSPVPVEIRVDLRVNRASYTFLREALQSSVDSLLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRIDLRFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYFLAQMGRFICLRELSIGSSLLSGRLDQLLSTLQRPLESLELAFCALLPEDLRFLAQSSHAAHLKKLDLSGNDLSGNQLTPFQGLLQAVAATLLHLELTECQIADAQLLATLPTLTRCASLRYLGLYGNPLSMAGLKELLRDSVIQAELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEAELHQLLLASGRAHVLWTTDIYGRLAADYFNL
What is the function of this protein?
Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.
What are the official names of this protein?
Leucine-rich repeat-containing protein 14.
What is the protein family that this protein belongs to?
Belongs to the PRAME family. LRRC14 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_SHELP
Sequence: MELVLKDAQSALEVSETTFGRDFNEALVHQVVVAYAANARQGTRAQKTRAEVTGSGKKPWRQKGTGRARAGTVKGPIWRGGGVSFAAKTQDHSQKVNKKMYRGALKSILSELVRQDRLVVVESFGVEAPKTKELKAKLKDMKLEDVLIVTPEIDENLFLAARNLYKVDVRDVAGIDPVSLIAFEKVLVTADAVKQIEEMLG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: H3A05_CYRHA
Sequence: MKASRFLALAGLVLLFVVGYASESEEKEFPRELLSKIFAVDDFKGEERGCKGFGDSCTPGKNECCPNYACSSKHKWCKVYLGK
What is the function of this protein?
Selective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC(50)=1270 nM on Nav1. 1/SCN1A, 270 nM on Nav1. 2/SCN2A, 491 nM on Nav1. 3/SCN3A and 232 nM on Nav1. 7/SCN9A).  This toxin suppress Nav1. 7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics.  Short extreme depolarizations partially activate the toxin-bound channel, indicating voltage-dependent inhibition of this toxin.  This toxin increases the deactivation of the Nav1. 7 current after extreme depolarizations.  The toxin-Nav1. 7 complex is gradually dissociated upon prolonged strong depolarizations in a voltage-dependent manner, and the unbound toxin rebinds to Nav1. 7 after a long repolarization.  Moreover, analysis of chimeric channels showed that the DIIS3-S4 linker is critical for toxin binding to Nav1. 7.  These data are consistent with this toxin interacting with Nav1. 7 site 4 and trapping the domain II voltage sensor in the closed state.
What are the official names of this protein?
Hainantoxin-III 5, HnTx-III, Hainantoxin-3.5, Mu-theraphotoxin-Hhn2a, Mu-TRTX-Hhn2a, Peptide F7-18.76.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 15 (Hntx-3) subfamily.
What are the subcellular locations of this protein?
Secreted.