PharMolix/UniProtQA huggingface dataset:
Protein: ATR12_EMENI
Sequence: MAIIDTTKDLSALFTQQVRASPNALALEDDKTSYTYAELDKEVEELSRRLRSYGVSRDSLVGVLLPRSAHFVIACLAALRAGGAFLVLELAYPPDLLADVLEDATPAVVVTHRSETGKIKGSVPVISLDEPPVDANGHTVEPGPLPVDDDLDRLAFVSYSSGTTGKPKGIANPHRAPVLSYNLRFGVQDLQPGDRVACNVFFIWEILRPLIRGATVVAVPDDHSYDPAALVDLLASRHITETLMTPTLLATILSRHSDIGARLPELRTLWLNGEVVTTDLARRAIRALPNTRLLNCYSACETHEIACGDIKEIVSDESQYCPVGPLLDPKHAYIVNEQGEKVEEGVSGELCVGGPMLARGYINRPETTAKAFIPDPFSNSPGAVMYRTGDRARMLPSGLLEITGRVGAMIKLRGYSVVPGKVENDIVKHLAVRQCAVVAHGEGLERQLVAYIVADQEHSEERPTVEINSSGHSPGARRALTKFLAHYMIPALWVQVDELPTHEVSGKIDLKRLPPPPTEVLANGNGKKEDPIGIEDIAAIWAVALKVPKATLKPEDNFFDLGGHSLSIADLSSRLSRKFGFRIPIVRLAENSTLSGHLDTVRAIRDGHTAAVQADLPAVLRTDATLDEEIRSDAKICSLTDAKTVLLTGVTGFLGAFLLKDLVDSTSAHIICLVRFNEPEDDDQPGGVARIRRNLLDLGLWNDSIMERVEILPGNLSRSRFGLTPDAFQELAQRVDVIVHAAASVNLVYPYAALRAANVGGTREILRLASQGGATVQYVSTNGVLPPSGEKGWPEDTMLDMKDVPTKLLDGYGQTKWVAEQLVLEAGRRGLPVRVHRIGTVSGHSQSGAANAWDLLTALIVESIKLGKYPDVEGWRAEMTPVDFVSKAIIHLANQTAVEQTVFHIGDPDPVNTRSVFEDLKTLGYPTEPLSWDDWVALWTSQRGHVKGGDGGFTVDILRSGMPSIEFLRGIVVLDNSATRPIRREVERPKVDRFLLETYTRHWFARGWLKRPPIRQRQLSPIPKGPLSGKVAVVTGASSGIGAAVATALAREGAHVALGARRLDALESLKEKLSASGVKVVTCKTDVTDRKQVEGLVKAATEELGPVDILVACAGVMYFTMMANTQMDEWERTVDVNCKGILNSLASTVPGMLARGKGHVVAISSDAGRKVFPGLGVYSASKFFVEATLQALRLETAGQGLRVTAVQPGNTATDLLGMSTDAEAIKKYGEPSGAQILDPEDVANSIIYALRQPEHVAMNEILIEPRDEPI
What is the function of this protein?
NRPS-like enzyme with an unusual domain architecture that converts back glycine betaine to choline via a 2-step reduction mechanism, and thereby can be an alternative source of choline (PubMed:31061132).  Permits direct reutilization of endogenously stored glycine betaine for on-demand biosynthesis of choline and choline derivatives, including phospholipid phosphatidylcholine (PC) which has an essential role in maintaining membrane integrity and functionality, or choline-O-sulfate, a mean for intracellular sulfate storage (PubMed:31061132).  Glycine betaine is activated by the adenylation (A) domain, and transferred to the thiolation (T) domain (PubMed:31061132).  Movement of the phosphopantetheine arm to the thioester reductase domain R1 then allows thioester reduction by NADPH of glycine betainoyl thioester to glycine betaine aldehyde, which is in turn reduced to choline by the aldehyde reductase domain R2 (PubMed:31061132).
What are the official names of this protein?
Glycine betaine reductase ATRR, Nonribosomal peptide synthetase-like protein ATRR.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: OPHN1_HUMAN
Sequence: MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRTRFFETASRKTGSSQGRLPGDES
What is the function of this protein?
Stimulates GTP hydrolysis of members of the Rho family.  Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function.  Critical for the stabilization of AMPA receptors at postsynaptic sites.  Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals.  Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).
What are the official names of this protein?
Oligophrenin-1.
What are the subcellular locations of this protein?
Postsynapse. Presynapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm.
Protein: CLPP_NITSB
Sequence: MSYYIPYVIERTGRGERSYDIYSRLLKDRIIMLSGEINDAVASSIVAQLLFLEAEDPDKDIYLYINSPGGVITSGMSIYDTMNYIKPDVSTICIGQAASMGAFLLSSGTKGKRYALPHARIMIHQPLGGAQGQATDIEIQAKEILRLKKILNEILAENTGQSVKKIAKDTERDFFMSSEEAKEYGLIDQVLEKSAR
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YG45_YEAST
Sequence: MSRQSAFKFQNGNRHERACLSDVHKILIIILYSTKGKRELGKRITHFMYIHIFCTYLYQASIVQYCSSTLLNVIAFSWYPLNLIYKYEYILRSKLILMVCLDFARSGGVLDSGDVSL
What are the official names of this protein?
Putative uncharacterized protein YGR182C.
Protein: SPEB_ECOLU
Sequence: MSTLGHQYDNSLVSNAFGFLRLPMNFQPYDSDADWVITGVPFDMATSGRAGGRHGPAAIRQVSTNLAWEHNRFPWNFDMRERLNVVDCGDLVYAFGDAREMSEKLQAHAEKLLAAGKRMLSFGGDHFVTLPLLRAHAKHFGKMALVHFDAHTDTYANGCEFDHGTMFYTAPKEGLIDPNHSVQIGIRTEFDKDNGFTVLDACQVNDRSVDDVIAQVKQIVGDMPVYLTFDIDCLDPAFAPGTGTPVIGGLTSDRAIKLVRGLKDLNIVGMDVVEVAPAYDQSEITALAAATLALEMLYIQAAKKGE
What is the function of this protein?
Catalyzes the formation of putrescine from agmatine.
What are the official names of this protein?
Agmatinase, Agmatine ureohydrolase, AUH.
What is the protein family that this protein belongs to?
Belongs to the arginase family. Agmatinase subfamily.
Protein: Y965_GEOSW
Sequence: MNYSYPFSYDWSTQEIIDVIKFFEAIETVYEKGMEREKLMNIYRRFKEIVPSKSEEKKLCDEFEQASGYSSYRVMKKAKEAQNGDWIRME
What are the official names of this protein?
UPF0223 protein GWCH70_0965.
What is the protein family that this protein belongs to?
Belongs to the UPF0223 family.
Protein: IDI2_SACS2
Sequence: MPDIVNRKVEHVEIAAFENVDGLSSSTFLNDVILVHQGFPGISFSEINTKTKFFRKEISAPIMVTGMTGGRNELGRINRIIAEVAEKFGIPMGVGSQRVAIEKAEARESFTIVRKVAPTIPIIANLGMPQLVKGYGLKEFQDAIQMIEADAIAVHLNPAQEVFQPEGEPEYQIYALERLRDISKELSVPIIVKESGNGISMETAKLLYSYGIKNFDTSGQGGTNWIAIEMIRDIRRGNWKAESAKNFLDWGVPTAASIIEVRYSIPDAFLVGSGGIRSGLDAAKAIALGADIAGMALPVLKSAIEGKESLEQFFRKIIFELKATMMLTGSKNVEALKRSSIVILGKLKEWAEYRGINLSIYEKVRKRE
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_SALAI
Sequence: MPRKGPAPRRPLVADPVYNSPLVTQLVNKILLRGKRQLAETIVYEALEGCREKSGTDPVVTLKRAMDNVKPTLEVRSRRVGGATYQVPVEVRPARATTLGLRWLVTYARARREKTMVERLMNELLDASNGLGAAVKRREDTHKMAESNKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ASSY_LISIN
Sequence: MTKEKIVLAYSGGLDTSVAIQWLVESGYEVIACCLDVGEGKNLDFIKEKAITVGASASYTIDAKEEFAENFALIALQAHAYYEGKYPLISALSRPLIAKKLVEVARQEGASAIAHGCTGKGNDQVRFEVAIHALAPDLKVVSPVRDWKWSREEEINYAKEHNIPVPIDLDNPFSIDQNLWGRSNECGVLENPWTTPPEAAYDLTVSLEDAPDTADIVEITFDAGIPISLNGENMSLANLILTLNEIAGKHGVGRIDHIENRLVGIKSREVYECPAAVTLITAHKELEDLTFVREVAHFKPIIEQKISETIYNGLWFSPLTEALIAFLKSTQKFVNGTIRVKLFKGHAIVEGRKSPNSLYDENLATYTSSDTFDQDAAVGFIKLFGLPTKVSAEVNSKVTITTEV
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_BACC3
Sequence: MNIEQFQSMLEEKGITLSSRQLEQFEIYFETLVEWNEKMNLTAITEKEEVYLKHFFDSITAAFYYDFSKPFSICDVGAGAGFPSIPLKICFPHLKVTIVDSLQKRINFLNHLAQKLELSDVAFCHDRAETFGKKEGVREAYDIVMARAVARLSVLSELCLPLVKVGGTFIAMKGAAANEEIENGKYALEVLGGDLKEMSTFQLPFEESERNILLIEKKRKTPKKYPRKPGTPNKLPIEK
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YM007_YEAST
Sequence: MVHFIFIALRSMRFMRRLVRNLQYLLLPITSSLLFI
What are the official names of this protein?
Uncharacterized protein YML007C-A, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TDPZ2_MOUSE
Sequence: MSGDMEAKIWGSTQISVKEFCYEWTISNFSFCMGGIRRKIKSPVFSLVANEEVAWCLRVHPNGFDEESKDYLSVYLVLVNCPKRQVRAKFEFWIKNSQGEKYQYTQSLNVPSFQRKQNWGFSKFILRDSLLSHRNWLLPKDKLTLCCKVSIVGAILNMPGQNMIPAIKDPRHMLTDDLGKLWENPLFTDCSLLVAGHEIRAHKAILAARSPVFRAMFEHQMEERLANCFEIQELDFQVFKEMMDFIYTGKAPTLHSHSMACDVLAAAEKYGLEGLKVICEDSLCRNLSVENAAHTLIVADLHSTEQLKTRALHFIAVHASEVSKSSGWKSMVESHPHLVDERFHSLASAQSVFLESSFKCLKGF
What are the official names of this protein?
TD and POZ domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the Tdpoz family.
Protein: NANM_YERPS
Sequence: MTQLYPQYKKQLTTKIVLFSALSLLMMASLPNTYAEQYPDVPVPFKNGTGGKVENSLYVGLGSAGVSWFRLDTDKTGAGWQKVANFPGQPREQAVTVVLAGKLYVFGGVGKTNANDTQVRALDDAYRFDPQTNQWQQLATRAPRGLVGTVATTLDGSQAVLLGGVNKAIFDGYFTDLASAGSDEVRKSAVINAYFNQAPADYFYNRDVLIYDPQKNQWKSGGLLPFLGTAGSAISRMDNRLILINGEIKPGLRTAAVWQGLMQGNVLEWQPQPDLIGAETGSAQEGLAGAFSGISHKTVLVAGGANFPGAWKQFNRGHLYAHQGLEKQWHQQVYALVDNQWRIAGKLPQPLGYGVSIQGPDKVILIGGETTGGTATSAVTQLSWQGGKLHIE
What is the function of this protein?
Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers.  Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer.  In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
What are the official names of this protein?
N-acetylneuraminate epimerase, N-acetylneuraminate mutarotase, Neu5Ac mutarotase, Sialic acid epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanM family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NADA_PYRFU
Sequence: MEKVEELKKEIERLKKERNAIILAHNYQLPEVQDVADFVGDSLELARKATKVDADVIVFAGVDFMAETAKILNPDKIVLIPNKRATCAMANMLKVKHILEAKKKYPNAPVVLYVNSTAETKAYADVTVTSANAVDIIRKLDSDVIIFGPDKNLAHYVAKVTGKTIIPIPPEGHCYVHKKFTIEDVERAKKLHPNAKLMVHPECNPEVQEHADIIVSTGGMIRRACEWDEWVVFTEREMVYRLSKLYPNKKFYPAKEDAVCVGMKAITLQHVYESLRDMKYEVTVPEEIAEKARKAIERMLEMS
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase, QS.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR2_LEPIC
Sequence: MQVKLKVLLIGSGGRESAIAFYLRKSVLLSELKVFPGNGGFPDQELLPPDSFQVLDKNSVQSFLKQNPFDLIVVGPEDPLVAGFADWAAELNIPVFGPDSFCAQVEGSKDFAKSLMTEAKIPTAEYKTFSEYSDSLKYLESKSIPIVIKADGLAAGKGVTVATSKEMAQTALKEIFKDKKFGSSGNQVVIEEFMEGQEASIFAISDGDSYFLLPAAQDHKRAFDGDQGPNTGGMGAYCPAPVISESILQKVKEQIFDPMFDLFRKKGHPYRGLLYAGLMISPNGEPKVVEFNCRFGDPETQCVLAMLDGDLLELLYRASTGKIKGIQAAVKKGAAVVVVLAAQGYPDFYEKNIPLNLPETSGQNVHLFHAGTLKKDGKVFSSGGRILGIVAQGADLKSSVDQAYSFLEKIQAPKTFYRKDIGYRAL
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: RT09_NEUCR
Sequence: MMASLRHSITSALRSSRQGCSKSAQWQSLDQQFGALRISSRSLSTHAHDHNPNVDGQFIAAPALSIDNFKLHPYARAVPVSPSYFTRTPRFYDNYLSLEKLMEEYEDLPVIPATAVERVAWKTLEDIRKELGEQVKASEFARCLALVKRLNSIHPDLKPQEIKDVLDSFRRNVQPFTNVAKPIPIDQFGRACGVGKRKASSARAFVVEGTGEVLVNGKTLAEYFGRVHDRESAVWALRATNRIDKYNVWVKVEGGGTTGQAEAITLAIAKALLAHEPALKPALRRAGCVTRDPRKVERKKHGHVKARKMPTWVKR
What are the official names of this protein?
37S ribosomal protein S9, mitochondrial, Mitochondrial ribosomal protein 9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FLP27_CAEEL
Sequence: MFSLTQILTFLLVAITLMTFSSAQPIDEERPIFMERREASAFGDIIGELKGKGLGGRMRFGKRSSSPDISLAEMRAIYGGDQSNIFNFK
What is the function of this protein?
FMRFamides and FMRFamide-like peptides are neuropeptides.
What are the official names of this protein?
FMRFamide-like neuropeptides 27.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPF_ACIB3
Sequence: MVAQIRIGQGMDVHAFEEGNFVTLAGVQIPHTHGLKAHSDGDVVLHALCDALLGALALGDIGQHFPDTDPEFKGADSRVLLKHVYQLILDRGYHLNNADITVACERPKLAKYNLEMRQSIADVLNVDLNQISIKATTTEKLGFTGRQEGILATATVLISH
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: PROB_ECO27
Sequence: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQMLLTRADMEDRERFLNARDTLRALLDNNIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPLENRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEVIRICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRDDMITR
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MK15_CAEEL
Sequence: MTDDVDTHIHEKFDLQKRLGKGAYGIVWKAYDKRSRETVALKKIFDAFRNPTDSQRTFREVMFLQEFGKHPNVIKLYNIFRADNDRDIYLAFEFMEADLHNVIKKGSILKDVHKQYIMCQLFRAIRFLHSGNVLHRDLKPSNVLLDADCRVKLADFGLARSLSSLEDYPEGQKMPDLTEYVATRWYRSPEILLAAKRYTKGVDMWSLGCILAEMLIGRALFPGSSTINQIERIMNTIAKPSRADIASIGSHYAASVLEKMPQRPRKPLDLIITQSQTAAIDMVQRLLIFAPQKRLTVEQCLVHPYVVQFHNPSEEPVLNYEVYPPLPDHIQLSIDDYRDRLYEMIDEKKASFKRIQHEKIRPYGEDKSRAPIAQAECSDTDYDTARSLQRTTSMDKNNSSSHDSSSGTLRERAASAESRTSKDSNGEMRNGNGNTPSSIKQRRRSVERARLFANIKPSKILHPHKLISNY
What is the function of this protein?
Atypical MAPK protein.  Regulates primary cilium formation in sensory neurons and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280, PubMed:28745435).  Acts in dopamine (DA) neurons to support synaptic membrane dat-1 availability via activation of rho-1 thereby sustaining normal levels of DA clearance (PubMed:28842414).  Plays a role in male mating behavior, probably in part through regulating the localization of the polycystin pkd-2 (PubMed:28745435).  Functions postembryonically in the URX sensory neurons to constrain URX dendrite growth throughout lifetime, probably by restricting expansion of the subcellular sensory compartment at the dendrite ending (PubMed:29879119).
What are the official names of this protein?
Mitogen-activated protein kinase 15, Swimming-induced paralysis protein 13, SWIP-13.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
What are the subcellular locations of this protein?
Cell projection, dendrite. Note=Enriched localization at the URX dendrite ending. SUBCELLULAR LOCATION: [Isoform a]: Perikaryon. Cell projection, dendrite. Cell projection, cilium. Cell projection, cilium membrane. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cell junction. SUBCELLULAR LOCATION: [Isoform c]: Perikaryon. Cell projection, dendrite. Cell projection, cilium. Cell projection, cilium membrane. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cell junction.
Protein: FLHD_ERWAC
Sequence: MGTSELLKQIYDINLSYLLLAQRIINQEKVSAMFRLGIDEAMADALARLTLPEMVKLAETNQLVCQFRFDDHQSISRLTRESRVEDLQQIHTGILLSSRLLRNVTKEQETPKKRAAS
What is the function of this protein?
Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region.  Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes.  Also regulates genes whose products function in a variety of physiological pathways.
What are the official names of this protein?
Flagellar transcriptional regulator FlhD.
What is the protein family that this protein belongs to?
Belongs to the FlhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_ACIBS
Sequence: MKFEKLGQSGRARRGRLTLEHGVVETPIFMPVGTYGTVKGMLPRDIEDIQAQIILGNTFHLYLRPGLEVIKQHGGLHDFIKWNKPILTDSGGFQVFSLGAMRKIKEEGVTFRSPIDGSKVFLSPEISMEIQHVLNSDIVMIFDECTPYPATHEEAQKSLQLSLRWAKRCKAHHHDELKNKNALFGIIQGGMYEDLRDESLNGLLEIGFDGYAIGGLSVGEPKEEMIKVLDYLPNKMPHDKPRYLMGVGKPEDIVEAVRRGVDMFDCVMPTRNARNGHYFVTDGLVRIRNSKYRHDQGPLDPHCDCYTCKNFTRAYLFHLEKCGEMLASMLGTIHNLRYYQRLTEGMRDALDKGTFDEFVQDFYARRGLEVPPCPVDE
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PIMT_AZOSB
Sequence: MSGRQDASHAGRARARMVERLRAQGIQDEGALAAMMQVPRHLFVEEGLAYSAYDDTALPIGFQQTISQPYVVARMIELLRSGGRQLGRVLEIGAGCGYQAAVLSTLATEVYAVERIRPLLDKARANLRPLRLPNVRLKHADGTLGLPEAAPFESIIVAAAAGGVPNALKEQLAPGGRLIIPVGGGEQRLLLIERQGNVFRESGYEAVRFVPLLAGTE
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_EDWI9
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYTGAITGAEGKIHRLEDWGRRQLAYSINKLHKAHYVLMNVEASQEVIDELETNFRYNDAVIRSMVMRTKHAVTEASPMVKAKDERRERREDFANETSEETEAGDSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: GCSH3_ARATH
Sequence: MALRMWASSTANALKLSSSASKSHLLPAFSISRCFSSVLEGLKYANSHEWVKHEGSVATIGITDHAQDHLGEVVFVELPEANSSVSKEKSFGAVESVKATSEILSPISGEVIEVNTKLTESPGLINSSPYEDGWMIKVKPSSPAELEALMGPKEYTKFCEEEDAAH
What is the function of this protein?
The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity).
What are the official names of this protein?
Glycine cleavage system H protein 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HEM1_BURCH
Sequence: MQLLTIGINHHTAPVALRERVAFPLEQIKPALVTFKNVFLGPQAPNTPEAAILSTCNRTELYCATDDRAAREGAVRWLSEYHRIPVDELAPHVYALPQSEAVRHAFRVASGLDSMVLGETQILGQMKDAVRTATEAGALGTYLNQLFQRTFAVAKEVRGTTEIGTQSVSMAAAAVRLAQRIFEKVSDQRVLFIGAGEMIELCATHFAAQGPRELVVANRTAERGQRLAERFNGRAMPLADLPTRMHEFDIIVSCTASTLPIIGLGAVERAVKARRHRPIFMVDLAVPRDIEPEVGKLKDVFLYTVDDLGAIVREGNASRQAAVAQAEAIIETRVQNFMQWLDTRSVVPVIRHMHTQADALRRAEVEKAQKLLARGDDPAAVLEALSQALTNKLIHGPTSALNRVNGADRDSLIDLMRGFYQHAPRSNDQSGH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: MMP23_HUMAN
Sequence: MGRGARVPSEAPGAGVERRWLGAALVALCLLPALVLLARLGAPAVPAWSAAQGDVAALGLSAVPPTRVPGPLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLDRLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSYPGYLALGEAHLSIIANAVNEGTYTCVVRRQQRVLTTYSWRVRVRG
What is the function of this protein?
Protease.  May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).
What are the official names of this protein?
Matrix metalloproteinase-23, MMP-23, Femalysin, MIFR-1, Matrix metalloproteinase-21, MMP-21, Matrix metalloproteinase-22, MMP-22.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein. Note=A secreted form produced by proteolytic cleavage may also exist.
Protein: CUTC_GLAP5
Sequence: MKVEICVDNLESVITANQFPIDRIELCSALAVGGLTPNLGFIQQAQQISTIPLALMIRPRAGDFLYSEDEIQIMLNDIATAKQLGIQAVVFGALSANGEIDLATTELLVKASQGMEITFHRAFDLCKDPITALEQLIDLGCHRILTSGQAATAFDGIPVIQQLVKQANGRIQVMAGCGVNADNVKQIIEQTKVPEIHFSAKGQRQSLMDSISSARMGTSSQDNVLDIADSQKIKGILKYISLL
What are the official names of this protein?
PF03932 family protein CutC.
What is the protein family that this protein belongs to?
Belongs to the CutC family.
What are the subcellular locations of this protein?
Cytoplasm.