PharMolix/UniProtQA huggingface dataset:
Protein: RECA_CHRVO
Sequence: MASEDKSKALAAALAQIEKQFGKGSIMRMSDNQITENLQVISTGSLTLDLALGVGGLPRGRVVEIYGPESSGKTTLCLQAVAEAQKLGGTCAYIDAENALDPVYAQKLGVNVEDLLISQPDTGEQALEICDMLVRSSGVDVIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTGNIKRTNTLVIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRTGGIKKGDEVIGNDTRVKVVKNKVSPPFRQADFEILYGEGISRQGEIIELGVKHGFIDKSGAWYAYNGQKIGQGKDNTREWLKANPAIADEIERKIREAVGVKIEINENQGDEEFADDAFDA
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPM2_MOUSE
Sequence: MATGTDQAVGFGLVAVSLIIFTYYTTWVILLPFIDSQHVIHKYFLPRAYAVLLPLAAGLLLLLFVGLFITYVMLKSQKITKKAQ
What is the function of this protein?
Regulates the biosynthesis of dolichol phosphate-mannose.  Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1.  Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.  May act by regulating the GPI-GNT complex.
What are the official names of this protein?
Dolichol phosphate-mannose biosynthesis regulatory protein, Dolichol-phosphate mannose synthase subunit 2, DPM synthase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the DPM2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NDUB4_BOVIN
Sequence: MSFPKYEASRLSSLPTTLDPAEYDISSETRKAQAERLAIRSRLKREYQLQYYDPSRRGVIEDPALVRWTYARSANIYPNFRPNTKTSLLGALFGIGPLVFWYYVFKTDRDRKEKLIQEGKLDRTFNISY
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4, Complex I-B15, CI-B15, NADH-ubiquinone oxidoreductase B15 subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFB4 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
Protein: HTPX_ALISL
Sequence: MKRIALFLATNLAVMIVFSIVLNIVYAVTGIQQGSLSGLLVMAVLFGFGGSLVSLLMSKKMALRSVGGEVIEQPRNETEHWLMETVSRQAQQVGIGMPTVAIYDSPDMNAFATGAKRDDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMITMTLMQGVVNTFVIFLSRMIANAVSGFTSNDEEGEGEGGSFMTYFIVSTVLEIAFGFLASFLTMWFSRHREFYADAGAANLVGKDKMIAALERLRMGQESQLEGSMMAFGINGKKSLTELLMSHPPLEKRINALRQL
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLUQ_VIBCH
Sequence: MHLKGKSPMNYIGRFAPSPSGPLHFGSLIAALGSYFQAKAQQGTWLVRIEDLDPPREMPGAAAHILRTLEAYRLHWDGTVVYQSQRHALYQDQIDAWLSTGQAYYCQCTRKAIKAMGGFYNGHCKIHPPARQQDCSIRLRMDNQVQQFIDLKHGTITIPKALAEEDFIIKRRDGLFAYNLAVVLDDIDQGVTQVVRGADLIEPTGRQISLYHTLKQKPVSYLHLPLAMDGNGNKLSKQNHAPAIDPTAPRQTISHAMQFLGFTLPTDFSDASAEQMLAWGCQHWQVSQLPEAIEITPRFSNGPA
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: KTHY_STRZP
Sequence: MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVKVLTTREPGGVLIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDLEGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: MNMA_DESVM
Sequence: MKIAVALSGGTDSLFALLLLLEQGQDVFGLHARFLPPRADQPSGNPDPAEAIGAMCARLGVDFHAVDLADAFEEAVVAPFIEEYVVGRTPNPCARCNATMKFGLLLDAARALGAARLATGHYVRQLRHPQWGMTLQRGADPAKDQSYFLSLVDRARLEQAVFPLGNWRKEQVKAELVKRNIVPPLPSESQEICFVPGDDYRAFLRDRQVRLPGPGPIVTMRGRKIGSHKGLWQYTEGQRRGLGIAWEEPLYVVSKDMENNVLLVGGREHLAARGCLTEDVNLLVDPADWPAEISVRTRYRQAPQPARVTVGDTGMAVRFREPQTPPARGQVAAVYDAEGHVLAGGVILGPV
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNFD_VIBC3
Sequence: MAFFIASSPHLRSKRSTADVMRWVLVCALPGLIAQTYFFGYGTLIQLLLAISVAVALEAGIMLLRKRSPISALRDYSAVVTAWLLAVAIPPLSPWWVVVIGLIFAIVIAKHLYGGLGQNPFNPAMIAYVVLLISFPVQMTSWMAPIKLTAEPSSLVDSFSLIFGGFDSDGLSLQQIRTGIDGITMATPLDAIKTSLKAGHTMSETLTQPQFSGFAGIGWEWVNIAYLLGGLILLKLRIIRWHIPVAMLAGLVFTALLAQLFAPGTTASPMIHLLSGATMLGAFFIATDPVSASTTDKGRLIYGFFIGAMVFLIRSWGGFPDGVAFAVLLANMCVPLIDYYTKPRTYGH
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ASTB_ECOL6
Sequence: MNAWEVNFDGLVGLTHHYAGLSFGNEASTRHRFQVSNPRLAAKQGLLKMKKLAGAGFPQAVIPPHERPFIPVLRQLGFSGSDEQVLEKVARQAPHWLSSVSSASPMWVANAATIAPSADTLDGKVHLTVANLNNKFHRSLEAPVTESLLKAIFNDEEKFSVHSALPQVALLGDEGAANHNRLGGHYGEPGMQIFVYGREEGNDTRPSRYPARQTREASEAVARLNQVNPQQVIFAQQNPDVIDQGVFHNDVIAVSNRQVLFCHQQAFARQSQLLANLRARVNGFMAIEVPATQVSVSDAVSTYLFNSQLLSRDDGSMVLVLPQECREHAGVWRYLNELLAADNPISELKVFDLRESMANGGGPACLRLRVVLTEEERRAVNPAVMMNDTLFNALNDWVDRYYRDRLTAADLADPQLLREGREALDTLTQLLDLGSVYPFQREGGGNG
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: PANB_STAAR
Sequence: MKTVSQLIDMKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESTVQVTLADMIHHGRAVRRGAPNTFVVVDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVEKAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGIEHKAKFVKQFADFSVGVDGLKQYDQEVKSGAFPSEEYTYKKKIMNEVNNND
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP2CI_HUMAN
Sequence: MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
What is the function of this protein?
A cytochrome P450 monooxygenase involved in retinoid metabolism.  Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Cytochrome P450 2C18, CYPIIC18, Cytochrome P450-6b/29c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: URK_LACPL
Sequence: MTENKHRRPVVIGVTGGSGSGKTTVSNAIYNQLSGQSLLILQQDSYYNDQSEMTMAERHAVNYDHPLAFDTDLMIKQIKQLLAYQPIEKPVYDYEQYTRSDKTIHQEPRDVIIVEGVLILDDQRLRDLMDIKVFVDTDDDIRIIRRIQRDIKERGRTLDSVIGQYLATVKPMYHQFVEPTKRYADLIVPEGGENEVAIDLLTTKVRSIL
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_PSEF5
Sequence: MKTFTAKPETVKRDWFVVDAAGQTLGRLATEIASRLRGKHKPEYTPHVDTGDYIVVINAEQVRVTGAKTTDKMYYSHSGFPGGIKSINFEKLIAKAPERVIETAVKGMLPKNPLGRDMYRKLKVYAGAAHPHTAQQPQELKI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: PP1A_RABIT
Sequence: MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
What is the function of this protein?
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets.  Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis.  Involved in regulation of ionic conductances and long-term synaptic plasticity.  May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.  Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.  Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.  Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development.  In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation.  May dephosphorylate CSNK1D and CSNK1E (By similarity).  Dephosphorylates CENPA (By similarity).  Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PP-1A.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles (By similarity).
Protein: DHHB_XENLA
Sequence: MPAVRILILAACCCWLLLLPVRCCGPGRGPVGGRRRYMRRLVPLLYKQFVPNVPEKTLGASGKSEGKIRRGSERFIKLVPNYNPDIIFKDEENTGADRLMTERCKDRVNALAISVMNMWPGLKLRVTEGWDEDGHHAHDSLHYEGRALDITTSDRDRNKYGMLARLAVEAGFDWVYYESKAHIHVSVNTDNSLGVRSGGCFPGTAMVMMETGKKKPLSELKLGDTVFTTDETGLLIHSVVLLFLHRDPYKTATFVLIEAEGHPTKLLVTPNHLLFIKSSSSTGFQPTFAYRVQIGDLIQIYVNGTQVQSSKVVRVSVDEQTGVYAPMTEHGTLLVDGVLTSCYATVESHTLAHASLAPLRLFQGIASMLPDLHTSDGVHWYCHILYVLAKYVLWWDMP
What is the function of this protein?
The dually lipidated desert hedgehog protein N-product (DhhNp) is essential for a variety of patterning events during development (By similarity).  Involved in the early induction and patterning of anterodorsal ectoderm, nervous system and somites.  Induces ectopic cement gland formation in embryos (PubMed:7671800).  Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity).
What are the official names of this protein?
Desert hedgehog protein B, Desert hedgehog protein 2, DHH-2, Hedgehog protein 4, X-HH4.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Desert hedgehog protein B N-product]: Cell membrane; Lipid-anchor. SUBCELLULAR LOCATION: [Desert hedgehog protein B]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted. Cell membrane. Note=Co-localizes with HHAT in the ER and Golgi membrane.
Protein: RL24_STRM5
Sequence: MANRIKKGDQVVVNAGKDKGKQGEIVRVDGDRVVVANVNIVKRHTKPNPQAGVAGGVVEREASIHISNVNVLNPASGKGERVGFKVLEDGRKLRVFRSSGEALDA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SYDND_CELJU
Sequence: MRSQYCGALNASHINQEVTLCGWVDRRRDHGGVIFIDLRDREGIVQVVFDPDGKDNFALADKVRGEYVLQVTGKVRARAAATVNPNMATGEIEVYGTALTILNEAQTIPFPLDSYANVGEDVRLKYRFLDLRRTEMQNNLRFRGKVTSAIRNYLDRHGFLDVETPILTRATPEGARDYLVPSRTHDGKFFALPQSPQLFKQLLMVAGYDRYYQIAKCFRDEDLRADRQPEFTQIDIETSFMSQDQIMAVTEGMFRELFKDLMNIEFEEIRHMPFSEAIAKYGSDKPDMRIPLELVDIKDLVTDVDFKVFAGPANDPKARVTALKVPGGNEKLTRKQIDDYTKFVGIYGAKGLAYIKVNDKSDLEEGLQSPIVKNLPVPVRAAILERVGADNGDLIFFGADKHKVVTEALGALRCKLGADLNLYTAQWAPLWVVDFPMFEEDDKGGWTSIHHPFTSPSCTPEELVANPGAALSRAYDLVLNGVELGGGSVRIHSPAMQQAVFKILGISPEEQREKFGFLLDALSYGAPPHGGLAFGLDRLVMLMVGASSIRDVIAFPKTQSAACVMTDAPGTVDELQLRELHIRLRNQKKEQPAADAPEYGM
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRSR1_HUMAN
Sequence: MDKKSFEMVLDEIRKAVLTEYKLKAIEYVHGYFSSEQVVDLLRYFSWAEPQLKAMKALQHKMVAVQPTEVVNILNCFTFSKDKLVALELLASNIIDAQNSRPIEDLFRVNMSEKKRCKRILEQAFKGGCKAPHAMISSCGTIPGNPYPKGRPSRINGIFPGTPLKKDGEECTNEGKGIAARILGPSKPPPSTYNPHKPVPYPIPPCRPHATIAPSAYNNAGLVPLANVIAPPPPPYTPNPVGTENEDLSNPSKPIQNQTFSTPASQLFSPHGSNPSTPAATPVPTASPVKAINHPSASAAATVSGMNLLNTVLPVFPGQVSSAVHTPQPSIPNPTVIRTPSLPTAPVTSIHSTTTTPVPSIFSGLVSLPGPSATPTAATPTPGPTPRSTLGSSEAFASTSAPFTSLPFSTSSSAASTSNPNSASLSSVFAGLPLPLPPTSQGLSNPTPVIAGGSTPSVAGPLGVNSPLLSALKGFLTSNDTNLINSSALSSAVTSGLASLSSLTLQNSDSSASAPNKCYAPSAIPTPQRTSTPGLALFPGLPSPVANSTSTPLTLPVQSPLATAASASTSVPVSCGSSASLLRGPHPGTSDLHISSTPAATTLPVMIKTEPTSPTPSAFKGPSHSGNPSHGTLGLSGTLGRAYTSTSVPISLSACLNPALSGLSSLSTPLNGSNPLSSISLPPHGSSTPIAPVFTALPSFTSLTNNFPLTGNPSLNPSVSLPGSLIATSSTAATSTSLPHPSSTAAVLSGLSASAPVSAAPFPLNLSTAVPSLFSVTQGPLSSSNPSYPGFSVSNTPSVTPALPSFPGLQAPSTVAAVTPLPVAATAPSPAPVLPGFASAFSSNFNSALVAQAGLSSGLQAAGSSVFPGLLSLPGIPGFPQNPSQSSLQELQHNAAAQSALLQQVHSASALESYPAQPDGFPSYPSAPGTPFSLQPSLSQSGWQ
What is the function of this protein?
Mediates OGT interaction with and O-GlcNAcylation of TET2 to control TET2 stabilization at enhancers and CpG islands (CGIs).
What are the official names of this protein?
Proline and serine-rich protein 1.
Protein: CD63_RABIT
Sequence: MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTITHGATPGSLLPVVIIAVGAFLFLVAFVGCCGTCKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNKDFRQQMQNYSTDNQTALILDRMQKDFTCCGAANYTDWATIPGMTRDRVPDSCCVNVTSGCGVKFNVKDIYVEGCVEKIGLWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRSGYEVM
What is the function of this protein?
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades.  Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases.  Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2.  Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2.  Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes.  Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking.  May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity).
What are the official names of this protein?
CD63 antigen.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, extracellular exosome. Cell surface. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies.
Protein: NDB4K_PANIM
Sequence: MKAQFAILLITLVLFQMFSQSEAIFGAIWKGISSLLGKRGLNNLNDFDELFDGEITKADLDFMREIMK
What is the function of this protein?
Amphipathic peptide that possesses relatively strong activities against Gram-positive bacteria and a fungus, but has very weak antimicrobial activities against Gram-negative bacteria.  Also exhibits mild hemolytic activities against human erythrocytes (16 uM induce 8% of hemolysis).  Minimal inhibitory concentration (MIC) are the following: 48 uM against S. aureus, 36 uM against B. magaterium, 18 uM against M. luteus, 36 uM against vancomycin-resistant Enterococci, 28 uM against methicillin-resistant S. aureus, 48 uM against E. coli, >87 uM against P. putida, >87 uM against K. oxytoca, >87 uM against E. cloacae, 68 uM against S. enterica and 16 uM against the fungus C. tropicalis.
What are the official names of this protein?
Pantinin-2, Non-disulfide-bridged peptide 4.21, NDBP-4.21, Non-disulfide-bridged peptide 5.22, NDBP-5.22.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: RR8_NEPOL
Sequence: MIQDTIADMLTRIRNANAMRIYTVCMPMTSVAREIAVILETEGWIDSWKEASVNSLILRLKYRGAKQQPILTGLRRVSRSGCRVYVSAKEVPKVLGGMGTAIISTSKGIMTDREARNHRLGGEVICLIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSAC_TRICV
Sequence: MSHTVKIYDTCIGCTQCVRACPTDVLEMVPWDGCKSGQIASSPRVEDCVGCKRCETACPTDFLSVRVYLGRLETTRSLGLAY
What is the function of this protein?
Apoprotein for the two 4Fe-4S centers FA and FB of photosystem I (PSI); essential for photochemical activity.  FB is the terminal electron acceptor of PSI, donating electrons to ferredoxin.  The C-terminus interacts with PsaA/B/D and helps assemble the protein into the PSI complex.  Required for binding of PsaD and PsaE to PSI.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.
What are the official names of this protein?
Photosystem I iron-sulfur center, 9 kDa polypeptide, PSI-C, Photosystem I subunit VII, PsaC.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: KDM7A_XENTR
Sequence: MAGAAPVYCVCRQPYDVSRFMIECDICKDWFHSSCVKVEEHQAADIDLYHCPNCEVLHGPSQLKKRRNWHRHDYTEPDDGTKPVQAGTRTFIQQLQARSFPSADDLLLKMNGSQLTQRYLEKQGFNLPIMVPRLDDLGLRLPPPTFSVMDVERYVGGEKIIDVIDVARQADSKMKLKNFVKYFMNPDRPKVLNVISLEFSDTKMADLVKVPDISKKLSWVENYWPDDSFFTKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKVFYLIKPSDENLALYESWSSSVTQSEEFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELKEDGFHPPNYLKHGVKALISALKSWMKKESVAEHAFEIPDNIRPGHLIKELSKVIRSVEEEGNRPVKSQGIHGHCPVSRSSHEKSSHHSGRKARRLRDHSTKTPTNLDILEHHTREVLKRLEMSPWEEDAGTYKLNMRFNKPLLPSSTEPDQKVRDNGIRLLLSNGRIIRDERQPFTDRSLYTADSEDEDDRARSRKAKDIKQEKPCSTSGMEDKAETQKPLNMFFESVKSELRNGSSEYSDISDSEGSEDNCTNQKHFSEESESSGDDDDEEEEEEEERQEPIRNLKEEHSGRRLPCDPNFPWPDHDSPQKRECPTSTSMEQEAVQGMLSMASLHYPSALPTPAKSTDCNIRGGYPQLHIRVSQGNGKEHLDSHSHKAANSDHHVKDEGEFSALDWIRQPDASCRLSPQDSCQVPQSLRREFAHEEYEKAPEDKHYLEIEHWDSAEYQPEKYDPESSMSSGECHLSDGSLSPTRIYGDTAAAVPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV
What is the function of this protein?
Histone demethylase required for brain development.  Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code (By similarity).
What are the official names of this protein?
Lysine-specific demethylase 7A, JmjC domain-containing histone demethylation protein 1D, Lysine-specific demethylase 7.
What is the protein family that this protein belongs to?
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
What are the subcellular locations of this protein?
Nucleus.