PharMolix/UniProtQA huggingface dataset:
Protein: IN80D_DICDI
Sequence: MNNNSNNNNNNNIDQKNETTNEITNNTSNNNNIINNVNQNSTSITTSPILSPNNNINDNSMMDGKRLCASSKKVCSKRPMETYRFCIKHILEEPSAPFKQCEFISLKSQKQCTNPVSIKEKDPRFCVSHKHIIESTKKRVLESVVSSITSPSSSSPLPNASLIGSNSNITSPLQNLTTLNAFTGNNNNNTTTTTTTTTTNSTPSLNFDQQINIDIDNINGGDEPNLSLSASSFNFNIISNNDEEPKKKIMKILDRHGISQGRFYQDFKQNLKQLKQKHKQKQQLQNQKMFEQSQQQDQQQKPVQQPIQQQQQQDQLQIQEERQVSQQDEILEKQQQQQQQQQQQQQQQQQQQQQQQQQKKQQQELQIENNKENENINESNYFGEEFIEKDLEIELFKAMDDGHLSELCEDFDSDFYFASSSVLTDEELIQRRKIYISKLILLYKKQYNRFKERLRIIRRHYISTSLSLNQQNDSNKMEIDNNNDNNINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKLNKRKEEGNLCLSVNCKVKPMLLSKYCYSHILQDKDQKLFHECTYQLSANKKCGYPILKVQIPTLCREHLDIYETNNEIIKSLPKKQKQFIKQRIDIEKHNAPSTLVPVTQPINQNNQNNNNNNTNNSSKEESKDNNNNNNNKEILKDSDNTMIS
What is the function of this protein?
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
What are the official names of this protein?
INO80 complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the INO80D family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YTCD_BACSU
Sequence: MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMPNITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHINRVYGDTFSVLEESVLNDKLKQES
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YtcD.
Protein: UCRI_PROM2
Sequence: MTQLSSKDVPSMGRRQFMNLLTFGTATGVALGALYPVANYFMPLRAGGGGGGTSAKDELGNPITKTGWLATHQAGDRSLVQGLKGDPTYLIVNEGGGIGEFGLNAICTHLGCVVPWDSGANKFICPCHGSQYDTNGKVVRGPAPLSLALAHVDIEDDAVLVKQWSETDFRTNENPWWA
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex iron-sulfur subunit, Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein, ISP, RISP, Rieske iron-sulfur protein.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein. Note=The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.
Protein: RL23_AQUAE
Sequence: MSQRKPWEIIIRPIITEKSNRLMEDYNKYTFEVALDASKPEIKYAVEKLFNVKVKKVNTMIVKPKKKRVWNKFRQYGTTKKWKKAIVTLEKGHKIDILEFAQK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: HNF1B_PIG
Sequence: MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPSFGVKLETLPLSPGSGTEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAADDGAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNLTDKSSQDQLLFLFPEFSQQSQGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEEAFRQKLAMDAYSSNQTHSLNTLLSHSSPHHQPSTSPPNKLPGVRYNQQGNNEVTSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMQISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNSSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYTHKQEPPQYSHTSRFPPAMVVTDTSSISTLTNMSSSKQCPLQAW
What is the function of this protein?
Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:8388098).  Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (PubMed:8388098).  Transcriptional activity is increased by coactivator PCBD1 (By similarity).
What are the official names of this protein?
Hepatocyte nuclear factor 1-beta, HNF-1-beta, HNF-1B, FPC-binding protein, FPCB, Transcription factor 2, TCF-2.
What is the protein family that this protein belongs to?
Belongs to the HNF1 homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TTC33_MOUSE
Sequence: MASFGWKRRIGEKVSKATSQQFEAEAADEKDAAENEDGNWLQASKRRKETLQEGCKQRSQQLKDEGAQLAENKRYKEAIQKWDEALQLTPGDATLYEMKSQVLLSLHEMFPAVHAAEMAVKRNPHSWEAWQTLGRAQLGLGEIVLAIRSFQIALHIYPMNPELWKEDLSWARKLQEQQKVAQRIENKEMPPEGPDLSPGSIPDYDFESDEIVAVCAAVAEKQKSVSANKTMVIVSASGTVEIVNEKEEGSSTPDGSVFIKAR
What are the official names of this protein?
Tetratricopeptide repeat protein 33, TPR repeat protein 33.
Protein: DNLJ_LISMO
Sequence: MADKKRYEELINILDQYSYDYYVIDNPTVEDAEYDQKMQELLKIEEAHPEWVTPESPSKRVGGEVLEGFKKVAHDTPMLSLANAFNHEDLADFDRRIRDKVGDDIAYMCELKIDGLAVSLQYENGKYKQGATRGDGTIGEDITANLRTIRSIPMKLQKDYSIEVRGEAFMPKRSFQKLNEIREEEGQMLFANPRNAAAGSLRQLDTKIAASRNLDIFLYAVADFGEMGVETHSAGLDMLETLGLKVNKERRLCSSLEEVYAYIDEWTEKRADLAYDIDGIVLKLNNLEQQRQMGTTVKSPRWSIAYKFPAEEVPTKLLDIELNVGRTGVITPTAVLEPVRVAGTTVSRASLHNEDLITEKDIRIGDTVLIKKAGDIIPEVIKSITEERSGSEEPFHMPKKCPTCDSELVRLEEEVALRCINPKCPAQIKEGLIHFVSRNAMNIDGLGEKVIIQLFSQHLIKDVADLFFLSKEKLLELERMGEKSVTNLLASIEASKQNSLEKLLFGLGIRHVGAKAAKSLAVHFETMDNLKVADKETLTSINDIGEKMADSIVTYFANEEVHDLLEELKRAGVNMTYTGPKLEDMSEEELVFAGKTVVLTGKLEKLTRNDAKALIESLGGNVSGSVSKKTDVVVAGSDAGSKLAKAEELAIPIWSEEDLIEYLPDEGGLNE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: RES_YERE8
Sequence: MMLYRIVMRRYLASTWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQDWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPRHKSFQTCLSSVQPLSFAFDPRLK
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Expression in E. coli inhibits cell growth; bacteriostasis is neutralized by expression of cognate antitoxin Xre (PubMed:30315706).  Probably depletes intracellular NAD(+) (By similarity).
What are the official names of this protein?
Toxin Res.
What is the protein family that this protein belongs to?
Belongs to the MbcT/ParT/Res family.
Protein: SUCC_THIDA
Sequence: MNLHEYQAKQVLRSSNLNTPRGIAATSADAAADAARELGGEAWVVKAQIHAGGRGKAGGVKVVTSIDAVRSVAAALLGKPLVTVQNAPDGQPVHTVLVEETLPIARELYLSLLVDRASERVAVVASAAGGMDIEQVAHATPEKVLTEICDPLLGVQDFQCRALAFALGLGGDAYKDFCRLLPQLYRVFVANDLSLLEINPLVVTTDNRVLPLDCKMSVDDNALYRRKALADLRDDSQIDAKEAAANAANVNYVALAGNIGCMVNGAGLAMATMDLIQLEGGAPANFLDVGGGATPETVAQGFKIILLDPNVKAVLINIFGGIVRCDVIAEGIIQAVREVGVEVPVIVRLEGTNAELGRTLLAESGLAIVAAESLTQAAKFAVEKAA
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: SECA_RHILW
Sequence: MVSFGGIARKLFGSSNDRRVRSFQPNVAAINSIEEKTKALTDEQLAAKTVEFRALLAEGKTLDDILIPAFAVVREASRRVLGLRPFDVQLVGGMILHSNAIAEMKTGEGKTLVATLPVYLNALSGKGVHVVTVNDYLAQRDAATMGRVYSFLGMTTGVIVHGLSDEERHAAYACDITYATNNELGFDYLRDNMKYEKNQMVQRGHNFAIVDEVDSILVDEARTPLIISGPLDDRSELYNTIDAFIPLLVPSDYEIDEKQRSANFSEEGTEKLENLLRQAGLLKGNALYDIENVAIVHHVNNALKAHKLFQRDKDYIVRNDEVVIIDEFTGRMMPGRRYSEGQHQALEAKERVQIQPENQTLASITFQNYFRMYAKLAGMTGTAQTEAEEFANIYNLDVIEVPTNLPIKRIDEDDEVYRTFDEKFKAIIEEILDAHKRGQPVLVGTTSIEKSELLAERLRKQGFDDFQVLNARYHEQEAYIVAQAGVPGAITIATNMAGRGTDIQLGGNLDMRIERELGEVEAGPEREARIQAIVEEIKELKQKALAAGGLYVIATERHESRRIDNQLRGRSGRQGDPGRSKFYLSLQDDLMRIFGSDRMDSMLTKLGLKEGEAIVHPWINKALERAQKKVEARNFDIRKNLLKYDDVLNDQRKVIFEQRLELMESTNISETVSDMRREVIEDLVDKHIPERAYAEQWDAAGLKTGALNILNLDLPIEDWVKEEGIGEDDIRERLTQATNAAFTEKAERFGDDIMHYVERSIVMQTLDHLWREHIVNLDHLRSVIGFRGYAQRDPLQEYKSEAFELFTSLLNNLREAVTAQLMRVELVQQAPAEPEPPLMQAHHLDPTTGEDDFAPAIYQASEVIVSPENRNPDDPATWGKVGRNETCPCGSGKKYKHCHGAFEQV
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RECF_CORA7
Sequence: MYIRDLDVRDFRSWPELTLRLKPGITLFVGRNGFGKTNIVEAIGYTAHLSSHRVAHDAPLVRQGAHNARISATAVNQGRELTAHLLIKPHAANQAQINRTRLKSPRELLGVVKTVLFSPEDLSLVRGEPAARRQYLDDIIASRTPRLAGVKADYDKVLKQRNALLKSASPSLRRGYSDSDGASALATLDVWDTQLSSLGAQVIQARLALVDELRELIPAAYAGLAPESRPAAIDYKSTVDISDREVIEAMMLTELATKRQREIERGISLVGPHRDDLVLNLGTSPAKGFASHGETWSYAISLRLAEFNLLRQDGTDPILILDDVFAELDAKRREKLVRLAAGAEQVLITAAVDEDLPGNLQPIERFTVTVRDTDEGRISEIAPYTAGGDEDD
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REN1_ARATH
Sequence: MANKNAESSSQPPPHVQPNQQQQQQPPIANEQEQEPHGDTCSIPPAQSGNTDSRSRGGNTVFKSGPLSISSKGIGWTSWKKRWFILTRTSLVFFRSDPSAVQQKGSEVNLTLGGIDLNNSGSVVVKADKKLLTVLFPDGRDGRAFTLKADTMEDLHEWKAALENALTQAPSASHVMGQNGIFRNDHADPAVGVDEKKDETPTKSTVLGRPVLLALEDVDGAPSFLEKALRFVENHGVRIEGILRQAADVDDVEHRIREYEKGKNEFSPEEDAHIIADCLKYFLRELPSSPVPASCCNALLEACRTDRGNRVNAMRAAICESFPEPNRRLLQRILMMMQTVASNKTVNRMNTNAVAACMAPLLLRPLLAGDCEIENDFDVGGDGSMQLLQAAAAANHAQAIVITLLEEYESIFGEGSLSPGLYSDSEESGSGTEEGSDDEEYDDDDDGSQGSEDYTDEEEDLENESNGSYSESAASEDKYADSIDPDDHKINDNLSTESKSPKRSKEPKKLLSGSRRSSLPRHDDGKKDEDIVVKGVNNTEVKAVVEVSTSEDKNSSTSDVASDTQKPSKLSDAPGGSKRHWGRTPGKKNLSMESIDFSVEVDEDNADIERLESTKLELQSRITEEVKSNAVLQASLERRKKALYGRRQALEQDVGRLQEQLQQERDRKLALETGLNMSKGNQPIPETIDENLKKDLQEVAQAEADIAKLEHKVDDLENRLGHHDGKASGSTHSASKESRKLPEHNAKMKEKQKDTEAASTHISERSTSKDGQGAARENETEKQQDSRSKSSQQETSRGSSKLVGLSKRSGTKGEGSTTTTSALSKLTMRLNFLKERRSQIANELQNMDKGKTLGQPSPTSGQNRVSEETEKGSGSNQDPDSSKLQSPHILDRGRSENGGDRGRGSSGGNHPNTTPRTFSR
What is the function of this protein?
Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state.  Maintains the global inactivation of ARAC11/ROP1 at the apex in pollen tubes in order to regulate the polar cell growth.
What are the official names of this protein?
Rho GTPase-activating protein REN1, Protein ROP1 ENHANCER 1, Rho-type GTPase-activating protein REN1.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Note=Localizes to the apical plasma membrane and accumulates in the clear zone of growing pollen tubes.
Protein: DMPM_STRAD
Sequence: MAPTEATRGGPADPAPAPEAHRGGHTEHADPAEHAAQFGAQERILTLVWGYISSEILDLATRLDLPDLMGTEERAAAELAASLDTDPVATLRLLRAFAALGLAEETGAGRFRLTPAGHRLRTDVPDSLHAFVRQGMGVFRQAWSHFDHSIRTGEPAFDQVFGTDFFSYLSERPELSGTFTSSMREATRTMSTALAKEEEYDFSSYGTVVDIGGADGSLLAAVLSAHPGVEGVVFDSPEGARDAAATLDAAGVGERGRVETGDFFTRVPGGGDLYVLKSILHDWSDARSADILRTVRAAMPAHARLLVVEVLLPDTVDSSAHPLGYLSDLYMLVNMGGRERSERDLRSLLSDTGFRTTRVRTPPGLTPFSLIEAAPV
What are the official names of this protein?
O-demethylpuromycin-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: RUVC_ALIF1
Sequence: MSIILGIDPGSRITGYGVIRQNGRHLQYLGSGCIRMSEKELPGRLKQIYAGVSEIITQFQPDVFAIEQVFMSKNADSALKLGQARGSAIVAAVNADLPVYEYAARLIKQAVTGTGGADKSQVQHMVMSMLKLPAKPQADAADALGAAICHANTNKTLIALAGKATGARRGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: DEF2_VIBCH
Sequence: MAVLEILTAPDPRLRVQSKQVTDVASVQTLIDDLLDTLYATDNGIGLAAPQVGREEAIVVIDLSDNRDQPLVLINPKVVSGSNKEMGQEGCLSVPDYYADVERYTSVVVEALDREGKPLRIETSDFLAIVMQHEIDHLSGNLFIDYLSPLKQQMAMKKVKKHVKNRAR
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 2, PDF 2, Polypeptide deformylase 2.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: GBP_COTKA
Sequence: ENFSGGCVAGYMRTPDGRCKPTFYQ
What is the function of this protein?
Biogenic peptide that prevents, in lepidopteran, the onset of metamorphosis from larva to pupa.  This growth-blocking peptide has repressive activity against juvenile hormone esterase.
What are the official names of this protein?
Growth-blocking peptide, GBP, Juvenile hormone esterase activity repressive peptide.
What is the protein family that this protein belongs to?
Belongs to the GBP/PSP1/paralytic peptide family.
Protein: KIF3A_MACFA
Sequence: MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELRGIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGIDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRDQAGKKKVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPRDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKEKDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKTGRRKRSAKPETVIDSLLQ
What is the function of this protein?
Microtubule-based anterograde translocator for membranous organelles.  Plus end-directed microtubule sliding activity in vitro.  Plays a role in primary cilia formation.  Plays a role in centriole cohesion and subdistal appendage organization and function.  Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole.  Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.
What are the official names of this protein?
Kinesin-like protein KIF3A, Microtubule plus end-directed kinesin motor 3A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to the subdistal appendage region of the centriole.
Protein: RNPA_PETMO
Sequence: MEGQTFKKKERLRLKRNFKNVFEKGGRLIDNNFVIIYVPNTMDYNRIAVIVNRKFGNAVVRNLIKRYIREIYRTNKTFFPLGYDFVFIPRKELSKNFKGIDYSQIKNQILKLVRKLEA
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: NU4LM_MACLA
Sequence: MNSINLNLIMAFSLALLGVLIYRTHLMSTLLCLEGMMLSLFILMALVISYFHMSSASMAPLILLVFSACEAGVGLALLVKISASHGNDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TPCA_ASPFU
Sequence: MERQPKSLCDATQLLETANIISDTVQTIIAEWSAEAKAPQGSGKQNAPMLPSRELFDAQRTILAAVGKLTELVSDPSARILEVATQFQESRSLYIAAERRIPDLLAAGDEGGVHIDQISQKAKIEPRKLARILRYLCSIGIFKQTGPDTFANNRISAALVSNEPLRAYVQLVNSEGFTASDRLPHTLLHPDTGPSYDVAKTAWQNAVCTKKTRWEWLEERVAPEQLLESGGHYPGIPSLVMGLPPREDDGLVARPELEIMGLSMVGGGRVFGTAHVYDFPWASLGDALVVDVGGGVGGFPLQLSKVYPQLRFIVQDRGPVVKQGLEKVWPRENPEALHQGRVQFVEHSFFDTNPTEGADIYFLRYVLHDWSDDYCVRILAAIRSSMAAHSRLLICDQVMNTTIGDPDLDSAPSPLPANYGYHTRFSHSRDITMMSCINGIERTPAEFKGLLQAAGLKLKKIWDCRSQVSLIEAVLPEMNGFR
What is the function of this protein?
O-methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC (PubMed:26242966).  The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC (PubMed:26242966).  The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone (PubMed:26242966).  The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin (PubMed:26242966).  Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:26242966).  Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (By similarity).  Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH.  Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin (PubMed:26242966).  Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death (PubMed:22319557).  The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway (PubMed:26242966).
What are the official names of this protein?
O-methyltransferase tpcA, Trypacidin synthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
Protein: PROB_BARQU
Sequence: MSGLIKTAGLQKLAHYKRIVVKIGSALLVEPQTGLRAEWLKSLINDVAKLHQKGVEILLVSSGAIALGRTLLRLPRGALKLEESQACAALGQIELAKTYGDALAQYGLKTGQILLTLLDTEERRRYLNARATINVLLRFGAVPVINENDTVATSEIRYGDNDRLAARVATMMGADLLILLSDIDGLYTKSPHRDPTAEFIPFIASITSDIEKMADVAASELSRGGMKTKLDAGKIANSAGTAMVITSGKRMNPLAAIDRGERRSFFAASEKPVNAWKTWISGHLGPSGILTIDPGAAKALESGKSLLAAGVIAVDGMFHRGDTVAIVDTNGVEIARGLVSYGKNEAVRIMGCKREEIESILGYEARSAMVHRNDMVLRCLTDST
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRX4_XENTR
Sequence: MSYPQFGYPYSSTPQFLMTTNSLSTCCESSGRSLSDSAAAASAQTPVYCPVYESRLLATARHELNSAAALGVYGSPYTSTQGYGNYVTYGADASAFYSLNAFESKDGTGSAHAGIPQTAAYYPYEHTLSQYQYDRYGTMDGSTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCSDEKRPYDEEEEEEEEEDSQKATIKNEKKIVDEEVAREDKALDLSDLEDFDAIESESSECELKQPFHHQPQDGHQLRQRDCVNDHCKDVILKMPITPAANQELDRTKICHKPGVDQCEQEVLRGRQRGGESKACFQQQQILDSKPRIWSLAHTATSLNQTEYPSCMLKHQGLSSPSSSSSSSAVSTPVCVIDRRQDSPVTSLRNWVDGVFHDPLFRHSTLNQALTNTTVSWATTKGTLIDSGSLGRSVGNPTNAIKGQLPNIPHDTNKEFIAFQKSGSKMFCS
What is the function of this protein?
Acts partially redundantly with other irx members in neural patterning.  Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord.  Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes.  Does not appear to play a role in pronephros kidney development.
What are the official names of this protein?
Iroquois-class homeodomain protein irx-4, Iroquois homeobox protein 4.
What is the protein family that this protein belongs to?
Belongs to the TALE/IRO homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HRP65_CHITE
Sequence: MDVKAEAPNGPAPVKNENQNQPKPQRENMNMNKNQNQNQNNNMGGGGGPNKRNNMNMNKNFQNRGGKGGPGMGPRGPMKNEDFIVNSKLKNLAGPTHDLPELVCEEIKFSGRNRLYIGNLTSDVTEEELKELFSPYGEISEAFINAEKNFAFLKIDYRANAERAKKDLDGRMRKNKPIRIRFAPNATTIRVKNLTPFVSNELLFKSFEVFGQVERAVIIVDDRGKTTGEGIVEFARKSGAMSALKYCSEKCYFLTSSLRPCVVETFDHIDETDGFPEKSLMRKSNDYYKARQNGPRFAEMGSFEHEFGTKWKQMYDMYKQKHDALKREMQLEEEKLEAQMEYAKFEHETESLREQLRKREQDRDRQKKEWEDRERQADESRIRDEQQMRRQQDDMQMRMQRQDEEMRRRQQENSLFMQAQQLSNMLDQQEMNHQGGGGGGGNGGNGNNQGGGGNQGGGRRNYNNDRNNDRNQNFDMMNQGGGNHGGNQYQGNQHYQGNQDQGNRFDGPPQRGNVRPWNNNDRGHRDDFQNKRRRY
What is the function of this protein?
Component of nuclear connecting fibers associated with the transport of ribonucleoprotein particles from either the chromosome to the nuclear pore complex or their transient retention in the nucleoplasm.
What are the official names of this protein?
Hrp65 protein, Ct-Hrp65.
What are the subcellular locations of this protein?
[Isoform 3]: Cytoplasm, cytoskeleton. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.
Protein: FIEF_ECO8A
Sequence: MNQSYGRLVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNLLVVRYSLQPADDNHSFGHGKAESLAALAQSMFISGSALFLFLTGIQHLISPTPMTDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHYQSDVMMNGAILLALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDEERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDSLPLVQAHMVADQVEQAILRRFPGSDVIIHQDPCSVVPREGKRSMLS
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.