PharMolix/UniProtQA huggingface dataset:
Protein: ACTN4_RAT
Sequence: MVDYHAANQAYQYGPSSGGNGTGGGGGMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTSVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHLRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL
What is the function of this protein?
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures.  This is a bundling protein.  Probably involved in vesicular trafficking via its association with the CART complex.  The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.  Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2.  Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions.  May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA.
What are the official names of this protein?
Alpha-actinin-4, Non-muscle alpha-actinin 4.
What is the protein family that this protein belongs to?
Belongs to the alpha-actinin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell junction. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, perinuclear region. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity).
Protein: VP7_ROTH4
Sequence: MYGIEYTTILIFLISIILLNYIVKSVTRIMDYIIYRFLLISVALFALTRAQNYGINLPITGSMDIVYANSTQEEIFLTSTLCLYYPTEASTQINDGEWKDSLSQMFLTKGWPTGSVYFKEYSSIVDFSVDPQLYCDYNLVLMKYDQNLELDMSELADLILNEWLCNPMDITLYYYQQSGESNKWISMGSSCTVKVCPLNTQTLGIGCQTTNVDSFEMVAENEKLAIVDVVDGINHKINLTTTTCTNRNCKKLGPRENVAVIQVGGSNVLDITADPTTNPQTERMMRVNWKKWWQVFYTIVDYINQIVQVMSKRSRSLNSAAFYYRV
What is the function of this protein?
Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved.  Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors.  Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion.  This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.
What are the official names of this protein?
Outer capsid glycoprotein VP7.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP7 family.
What are the subcellular locations of this protein?
Virion. Host endoplasmic reticulum lumen. Note=The outer layer contains 780 copies of VP7, grouped as 260 trimers. Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4. As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles.
Protein: MAT1_HUMAN
Sequence: MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS
What is the function of this protein?
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.  CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation.  CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts.  Involved in cell cycle control and in RNA transcription by RNA polymerase II.
What are the official names of this protein?
CDK-activating kinase assembly factor MAT1, CDK7/cyclin-H assembly factor, Cyclin-G1-interacting protein, Menage a trois, RING finger protein 66, RING finger protein MAT1, p35, p36.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSLU_STAAS
Sequence: MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMIGPTGVGKTEIARRMAKVVGAPFIKVEATKFTEVGYVGRDVESMVRDLVDVSVRLVKAQKKSLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGGAIPNFGQNNEDEEEPPTEEIKTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREVAVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQGVQRDILPILEGSVIQTKYGTVNTEHMLFIGAGAFHVSKPSDLIPELQGRFPIRVELDSLSVEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRLAEIAYQVNQDTDNIGARRLHTILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_SYNR3
Sequence: MSHISADDVRKVAQLARLDLPDDSIATFTPQLERILDFVAQLEAIDTEGLPPTTRAVEVVNVTREDGVEPTPVREELLNQAPQREGDFFRVPRILNN
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: PRIB_ECO57
Sequence: MTNRLVLSGTVCRTPLRKVSPSGIPHCQFVLEHRSVQEEAGFHRQAWCQMPVIVSGHENQAITHSITVGSRITVQGFISCHKAKNGLSKMVLHAEQIELIDSGD
What is the function of this protein?
Binds single-stranded DNA at the primosome assembly site (PAS).  During primosome assembly it facilitates the complex formation between PriA and DnaT.
What are the official names of this protein?
Primosomal replication protein N.
What is the protein family that this protein belongs to?
Belongs to the PriB family.
Protein: MNMG_PROM0
Sequence: MQDHHSTNESFDVIVIGGGHAGCEAAITTAKLGFSTALFTINLDRIAWQPCNPAVGGPAKSQLVHEVDALGGIIGKLADETAIQKRILNASRGPAVWALRAQTDKREYSKKMIEILQNTDNLSLKEAMITELDIAKTEEIGLNSKRTVKKRIKGVRTFFGSYYSARSVIITAGTFLEGRIWIGNKSMSAGRSGEQAAKGLTENLHEIGIKTERLKTGTPARVDKRSIIFDDLDIQPSTAADKYFSFDPDIKNNMPQVSCHITRTTTKTHQLIRDNLHLTPIYGGFIDSKGPRYCPSIEDKIVKFADKESHQIFLEPEGINTPEIYVQGFSTGLPENIQLELLRTLPGLNECKMLRPAYAVEYDYIPATQLQTSLETKEIEYLFSAGQINGTTGYEEAAAQGLVAGVNATRKLSKKDPIIFTRESSYIGTMINDLITKDLKEPYRVLTSRSEYRLTLRGDNADRRLTQLGYQIGLINEKRWSAYQEKMKLLEEEKFRLNKTRLKNTEEISKKIELETGSKIKGSITLKELLKRPDFHYSDLIKYNLTEKNLGSSIQEGVEIDIKYEGYLKRQKNNIEQINRQSCKSLPQEINYEKIETLSLEARENLNKIKPKNFGDASKIPGVSKADLTALLVWLKIREIKKEKANIFIEKKLSSKKHSV
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP31_BPAPS
Sequence: MEIKVIENIEQFYRFFTDKAKVGYAMENNGEYQLKNNQLYVGVYEGLMLVGFFSIEFIRNKLIEVHPVFEPGFRGQYALAATKRFSNWLINNIHFSTVITYVPEKTPWGKVICQLMKMRKVGVIDNALTAGHHQINMTLYQVTKEELVNGWKQRR
What are the official names of this protein?
Putative protein p31.
Protein: HIS5_BRUSU
Sequence: MRVAIIDYGSGNLRSATKAFERAAHESGISAEIDLTCDAQRVASADRIVLPGVGAYADCRRGLDAVPGMVEALNDTVLKKARPFLGICVGMQLMSERGLEKTVTNGLGWIAGDVREMVPSDASLKIPQIGWNRIHVKHSHPIFDGIPAGDDGLHAYFVHSYMLDAKNASDVLAVTDYGGDVTAAVGRDNMVGTQFHPEKSQLLGLSLIANFLKWKP
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MACB_WOLSU
Sequence: MQKPLIELKGVSRVFNLGGLAVEVLKGIDLQIYPGEFVAIMGASGSGKSTLMNILGCLDRPSQGEYLFRGESVSLLHRDDLAQLRREEFGFIFQSYHLIHALDARENVEVPAIYAGAGIVEREKRAEELLGSLGLGERLHHRPSQLSGGQQQRVSIARALMNGGRVILADEPTGALDSRSGEEVMQLLMELSRQGHTIILITHDSHVASHANRVIEMKDGQITHRQEPVIRESNQVRSPFGVRHSSILLELFEAMKMAFRSLKMNLFRTVLTLLGIVIGVASVIVMLAIGDGAKNAVLERISAMGTNILVIRPGMPNSRGFSNIATLIPEDMEAIMELDNIIAAMPENKKSVTTRYGNNDQSTSLNATSSHFTKVRNWPLGKGVFFTEEDEKSYAKVVVLGKTVEKALFGEEDALGRFILVDNIMFQIIGVMSNRGASASGEDEDDVILVPYTTGSLHLIGQKFLRNITVAVDDLSRMGETEREIHSLLLARHGGIEDFRIRNMASLIEDVTQTQNTLTILLGSIAAISLLVGGIGVMNIMLVSVTERTKEIGIRIATGARMRHILQQFLIEAVVVSALGGLIGVVIGLGVSALIEGLGTPVYYSLMPIVWAFGCAFVTGLLFGYLPARKAARLDPVVALASE
What is the function of this protein?
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRPC_SYNP6
Sequence: MEVRRRPPNPAVHVASLTYQVKVPGSSPSNILEEIVWYKEREVNAWREQLPLQQLQNQVRGLTQTPRDFLAALRQAPTRPAVIAEVKKASPSKGVLREDFDPVAIAQAYAANGAACISVLTDEKFFQGGFENLQRVRAAVDVPLLCKDFVIYPYQIYKARLLGADAVLLIAAILSDADLRYFLKIAHSLGLNALVEVHSLPELERVLALDDLRLVGINNRNLKTFVTDLAVTEHLAAQCRDRDLLLVSESGLFTGADLDRVTQAGAQAVLIGESLVKQPDPGLALQQLVGDRPSA
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: OTOP3_MOUSE
Sequence: MASQTSAPAEPAPMPSPEAKTTEGASSYDQADMETKHAGSPCPPKQKSWLARHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVSVTLGDVWILLAALKVLSLLWLLYYTVGTTRKPHAVLYRDPHAGPIWVRGSLVLFGSCTVCLNIFRMGYDVSHIHCKSEVELIFPAIEIVFMIIQTWVLWRHCKDCVQVQTNFTRCGLMLTLATNLLMWVLAVTNDSMHREIEAELDALMEKFSGNGTNTCMCLNTTVCEVFRKGYLMLYPFSTEYCLICCAVLFVMWKNVSRSLAAHTGAHPNRSPFRLHGTIFGPLLGLLALVAGVCVFVLFQIEASGPDIARQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTLKNPTRSLDVVLLMGAALGQMGIAYFSIVAIVATQPHELLNQLILAYSLLLILQHITQNLFIIEGLHRRPLWEPAVSGVMEKQDVELPRRGSLRELGQDLRRASRAYIHSFSHLNWKRRMLKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYRTWFTIVNFGLPLGVFYRMHSVGGLVEVYLGA
What is the function of this protein?
Proton-selective channel that specifically transports protons into cells.  Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
What are the official names of this protein?
Proton channel OTOP3, Otopetrin-3.
What is the protein family that this protein belongs to?
Belongs to the otopetrin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PCRB_STAAB
Sequence: MYDIKKWRHIFKLDSAKHISDDDLDAICMSQTDAIMIGGTDDVTEDNVIHLMSRVRRYPLPLVLEISNIESVMPGFDFYFVPTVLNSTDVAFHNGTLLEALKTYGHSIDFEEVIFEGYVVCNADSKVAKHTKANTDLTTEDLEAYAQMVNHMYRLPVMYIEYSGIYGDVSKVQAVSEHLTETQLFYGGGISSEQQATEMAAIADTIIVGDIIYKDIKKALKTVKIKESSK
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
Protein: HECAM_BOVIN
Sequence: MKREREAPSRAFSALRLAPFVYLLLIQTEPLEGVNITSPVRLIHGTVGKAALLSVQYSSTSSDKPVVKWQLKRDKPVTVVQSIGTEVIGTLRPDYRDRIRLFENGSLLLSDLQLADEGTYEVEISITDDTFTGEKTINLTVDVPISRPQVLVASTTVLELSEAFTLNCSHENGTKPSYTWLKDGKPLLNDSRMLLSPDQKVLTITRVLMEDDDLYSCVVENPISQGRSPPVKITVYRRSSLYIILSTGGIFLLVTLVTVCACWKPSKKSGKKRKLEKQNSMEYMDQSDDRLKPEADTLPRSGEQERKNPMALYILKDKDSPEPEENPASEPRSAAEPGPPGYSVSPAVPGRSPGLPIRSARRYPRSPARSPATGRTHSSPPRAPGSPGRSRSASRTLRTAGVHLIREQDEAGPVEISA
What is the function of this protein?
Involved in regulating cell motility and cell-matrix interactions.  May inhibit cell growth through suppression of cell proliferation (By similarity).
What are the official names of this protein?
Hepatic and glial cell adhesion molecule, glialCAM, Hepatocyte cell adhesion molecule, Protein hepaCAM.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=Colocalizes with CDH1.
Protein: RR9_TRICV
Sequence: MNTKIGLSLSEKYYWSWKTKTSNCPCFSCSGEGNIVINKVSGEKYLQYNLTYLKDIWAPLKELNLEKQFDIIALVRGGGLTGQTESIQLGVARLLCQMNPQNRSVLKPFGFLTRDARIKERKKYGLRKARKAPQYSKR
What are the official names of this protein?
30S ribosomal protein S9, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IF1_STRA3
Sequence: MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPYDLTRGRITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNTN1_MOUSE
Sequence: MKMPLLVSHLLLISLTSCLGDFTWHRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTNDRYSMVGGNLVINNPDKQKDAGVYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVKVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVESSDRGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDIYTMMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGLYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCIATGKPIPTIRWLKNGYSYHKGELRLYDVTFENAGMYQCIAENAYGSIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITNPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKEITHIHYQRNFMLDANGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMESAKAVDLIPWMEYEFRVVATNTLGTGEPSIPSNRIKTDGAAPNVAPSDVGGGGGTNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMTPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWKHVLEKIVESYQIRYWAGHDKEAAAHRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPSSDVIETFTRKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKILYRPDGQHDGKLFSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGVSTLSSSLLSLLLPSLGFLVYSEF
What is the function of this protein?
Contactins mediate cell surface interactions during nervous system development.  Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1.  Participates in oligodendrocytes generation by acting as a ligand of NOTCH1.  Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus.  Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
What are the official names of this protein?
Contactin-1, Neural cell surface protein F3.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. Contactin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: EFP_SHESA
Sequence: MKTAHEVRPGNVIMFEGSPWVVQKTETTRSGRNAAIVKLKLKNLLLNSGTETTFKGEDKIDDIILDRLDCTYSYFADPMYVFMDAEYNQYDVEAENLGDAAAYIVDGMEETCQVTFYEGKAISVEMPTTIVREVIYTEPSARGDTSGKVMKPATITGGGTISVADFVKVGDKIEIDTRTGEFKKRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHBG_ECO5E
Sequence: MERLLIVNADDFGLSKGQNYGIIEACRNGIVTSTTALVNGQAIDHAVQLSRDEPSLAIGMNFVLTMGKPLTAMPGLTRDGVLGKWIWQLAEEDALPLEEITQELASQYLRFIELFGRKPTHLDSHHHVHMFPQIFPIVARFAAEEGIALRIDRQPLSNAGDLPANLRSSHGFSSAFYGEEISEALFLQVLDDSSHRGERSLEVMCHPAFVDNTIRQSAYCFPRLTELEVLTSASLKYAIAERGYRLGSYLDV
What is the function of this protein?
Involved in the degradation of chitin.  ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose.  Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF.  Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF.
What are the official names of this protein?
Chitooligosaccharide deacetylase, COD, Chitin disaccharide deacetylase, Chitobiose deacetylase, Chitobiose-6P deacetylase, Chitotriose deacetylase, Chitotriose-6P deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family. ChbG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_CLONN
Sequence: MAGAGLIAIKRRIKSINNTKKITKAIGLVATSKLRKARQKLELNNAYYSSVNEIMNGILADKNLEKGIYFKDNGVNKKLYIVITSDSGLCGGFNGNVIAKTLETISGDRENSVIITVGKKGRTYLKKFKIDSIAEFVEIPEIPTLKEVKAILEKALNLYMNKEISEINVVYTHFVSSVKQEAKVKKILPITMEEDSEQTSTFVEFEPDKNIVLEGISELYLKQTLLNLMLNSKTSEESARMTAMDGATSNANDLLDKLNLQYNRIRQSSITQEISEIVGGAQAQE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SERP2_HUMAN
Sequence: MVAKQRIRMANEKHSKNITQRGNVAKTLRPQEEKYPVGPWLLALFVFVVCGSAIFQIIQSIRMGM
What is the function of this protein?
May interact with target proteins during translocation into the lumen of the endoplasmic reticulum.  May protect unfolded target proteins against degradation and facilitate correct glycosylation (Potential).
What are the official names of this protein?
Stress-associated endoplasmic reticulum protein 2, Ribosome-associated membrane protein RAMP4-2.
What is the protein family that this protein belongs to?
Belongs to the RAMP4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: RS7_BEII9
Sequence: MSRRHSAEKREVIPDAKYGDIILTKFMNSIMYDGKKSIAEAIVYGAFDIIEQKSHNEPLSVFKQALDNVAPSIEVRSRRVGGATYQVPVEVRSERRQALAIRWIITAARGRNDKTMIDRLSAELLDAANNRGNAVKKREDTHRMAEANRAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: GLGA_DECAR
Sequence: MSSLSILFATSEMAPWVKTGGLGDVAAALPAALRKAGHDIRVLLPAYPALKQAFPTATTVAELPAFAPGLPASRLLAAQTGKLELLLLDCPELYDRPGNPYLDATGRDWPDNALRFGLLSRVAARLGQPDSPLSWQPDIVHANDWQTALAPAYLHYQGGAASVVTVHNIAFQGCFGREMLAALGLPEHAWRFDGVEYHDQLSFLKAGLQLASQISTVSPTYAREIQDEHFGYGLAPLLRHRSAELRGILNGVDTDLWNPATDPVLATGYAANRLAAKRTNKAALQTEMGLEVTADRPLFGVISRLTSQKGLDLLLTVAEGLPELPAQLVVLGSGDKLMEAGFVELAKRFPAQIVVKIGFDEGLAHRIEAGADCFVMPSRFEPCGLNQMYSLRYGTPPIVRATGGLADTVVDVCEDTLADKSANGFVLDGDTPHALWLTIEHVCRTWQDKKLWQRIQQNGMRRDFSWTHAANEYVALYRDAIATRA
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: GREA_CAMJJ
Sequence: MQKEPMSQFGYDKLAAELKDLKDNQRPAVVIEIDTARSHGDLKENAEYHAAREKQALIESRIAELSDLLARAQVIDPSSYEHDSVKFGSSVVIIDLDTEKESKYTLVGICEGDLDKGYISIASPIAKAMLGKKEGDDFKVRLPKGESEFEILSINYEPLKF
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.