PharMolix/UniProtQA huggingface dataset:
Protein: EGLC_ASPFC
Sequence: MQFTHLVALALALATSEAAHQGFNYGNTKSDGSAKSQADFQAEFSTAKNLVGTSGFTSARLYTMIQGGTANTPISAIPAAITEQTSLLLGLWASGGNFANEIAALKAAIAQYGDDLAKLVVGISVGSEDLYRNSVDGVKANAGIGTNPDEIVSYINEVRSTIAGTKLSGAPIGHVDTWTAWVNGSNSAVIDACDWLGFDGYPYFQNTMANSISDAKALFDESVAKTQAVAKGKEVWITETGWPVSGKTENLAVANLANAKTYWDEVGCPLFGKTNTWWYILQDADPVTPNPSFGIVGSTLSTTPLFDLSCSASSSSSAAASSTAGPSASSVIGGKASGFTTAAANSAKPTFTVGKGPGGSYNGTGFWNSTSSARPSSSAISGSSSGSAAGSSGSSGSSGSGASGASGQSSSSTGSSSAPSTSNILSNAASGLSGSICGAVVAVCLALAAL
What is the function of this protein?
Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.  This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase (By similarity).
What are the official names of this protein?
Probable glucan endo-1,3-beta-glucosidase eglC, Endo-1,3-beta-glucanase eglC, Laminarinase eglC.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Secreted, cell wall. Note=Covalently-linked GPI-modified cell wall protein.
Protein: RPC3_ASPTN
Sequence: MSQYIAELCTLLVEDNFGELFGHIFATLIRYDRLTLPRLRLYSKLPDAQLRRGLAAMVQQHLVYHYTSYEEGVTYYEPNLQSAYYLIRAGKILEFIEERLGKYAATVMSTIMFLGHAQVSYLETLPELQPQAPTAVNGNHEQPEKEIEGEGVEGEGIEEEGHTNGVNGEEALEEQEEQAQPFLLHPTLKALAAHGYIHRVREAHFQSYADNVLDCERTIKARADIKQMKGKKLEETVLELTAEMLRERLDGDLTHGLVFNGVPRGAKRRRGPGGAERSNKKARVDYVAVDEDEEEEEENEWSEDEMGGDNIPMESGITVRVNYEKLDVALRNRRFLELAEQDCSAATIHVYECLLRRIEYKTKQCRDTPEIPREGEEGKQFAAPISLAAIAEDVDPSVDLAGSIGPMDPSQAVNRRGKRPLDDGVNGTHHDGPNGASSDGNRIYDVGQHLALLSEPPHNLTEKKVVANLPSWTVEFRSLACKLRHLELERMIEARYGDVALRVVRVLHAKGKLDEKRLQEISLLPFRVLRQVLASMQAGGFVDLQEVPRDAQRQPSRTIYLWFYDPDRTRASILEDTYKSMSRCLQRLRFERNRLKEFLEKTERSDVKGNEERYLSEAELTLLEQWRAKEALLLGEVARLDEMVAVMRDY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit rpc3, RNA polymerase III subunit C3.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ADD_VIBPA
Sequence: MITKNLPLTDLHRHLDGNIRTKTILELGQKFGIALPAYDIESLTPHVQIVEAEPSLVAFLSKLDWGVAVLGDLDACRRVAYENVEDALNAQIDYAELRFSPYYMAMKHKLPVAGVVEAVVDGVQAGMRDFGIKANLIGIMSRTFGTDACQQELDAILSQKDHIVAVDLAGDELGQPGERFVSHFKQVRDAGLNVTVHAGEAAGAESMWQAIQELGATRIGHGVKAIHDPKLMDYLAENRIGIESCLTSNFQTSTVDSLANHPLKQFLDHGVLACLNTDDPAVEGIELPYEYEVAAPAAGLSQEQIRQAQINGLELAFISDAEKAELKEKVKDRV
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: RSMB_ECOLC
Sequence: MKKQRNLRSMAAQAVEQVVEQGQSLSNILPPLQQKVSDKDKALLQELCFGVLRTLSQLDWLINKLMARPMTGKQRTVHYLIMVGLYQLLYTRIPPHAALAETVEGAIAIKRPQLKGLINGVLRQFQRQQEELLAEFNASDARYLHPSWLLKRLQKAYPEQWQSIVEANNQRPPMWLRINRTHHSRDSWLALLDEAGMKGFPHADYPDAVRLETPAPVHALPGFEDGWVTVQDASAQGCMTWLAPQNGEHILDLCAAPGGKTTHILEVAPEAQVVAVDIDEQRLSRVYDNLKRLGMKATVKQGDGRYPSQWCGEQQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIPELAQLQSEILDAIWPHLKTGGTLVYATCSVLPEENSLQIKAFLQRTADAELCETGTPEQPGKQNLPGAEEGDGFFYAKLIKK
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_STRM5
Sequence: MSQALTLARPYARAAFATARDEGAFAPWSDALAFSAHVAADPRVAALLANPELGRDDAVALLAPVTHGETYSRFLAILAESHRLPLLPEISGMFDALRADAEHVVKANVTSAAELSAGELDAIKTALRKRFNREVEVTTAVDASLIGGAVIDAGDVVIDGSLKGKLARLQTALAN
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: MSHA_CORJK
Sequence: MRVAMISMHTSPLEQPGTGDAGGMNVYVKNIAEQLERRGVIVDVFTRATRPLQGEVVNVRPGLRVINCVAGPYEGLSKEELPTQLAAFTGSILAFCREEGVSYDLIHSHYWLSGQVGWLLRDLWQVPWVHTAHTLAAVKNNSLADGDSREPESRRICEQQIVDNADLLIVNTDQEVQDLIEGYDATTCAIRVVPPGADVDRFTPGSDRATERSRRELGIPFRTKVIGFVGRLQRLKGPQVLLRAVAELLDRHPQQQLAVVICGGSSGAGGNELERLQLLAEELGISRCVRFLAPRPPEELVGVYRAADIVAVPSYNESFGLVALEAQACGTPVVATRTGGLPIAVDGGKSGLLVDGHDPSDWADALGKLVLDDDLRIAMGEYAPSHAAKFSWQASAEALHKLYEELPPAGHRGERQPAG
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: HEMA_I61A0
Sequence: MERIVLFLAIVSLVKSDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKTHNGKLCSLNGVKPLILRDCSVAGWLLGNPMCDEFLNVPEWSYIVEKDNPINSLCYPGDFNDYEELKHLLSSTNHFEKIQIIPRSSWSNHDASSGVSSACPYNGRSSFFRNVVWLIEKNNAYPTIKRSYNNTNQEDLLILWGIHHPNDAAEQTKLYQNPTTYVSVGTSTLNQRSIPEIATRPKVNGQSGRVEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAIMKSDLEYGNCNAKCQTPVGAINSSMPFHNIHPLTIGECPKYVKSDRLVLATGLRNVPQRETRRQKRGLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGITNKVNSIIDKMNTQFETVGKEFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLKDNAKELGNGCFEFYHKCDNECMESVRNGTYDYPQYSEEARLNREEISGVKLELMGVYQILSIYSTVASSLALAIMIAGLSFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: GLYA_NEIG1
Sequence: MFSKSVTLAQYDPDLAAAIAQEDRRQQDHVELIASENYVSCAVMEAQGSQLTNKYAEGYPAKRYYGGCEYVDIVEQLAIDRVKELFGAAYANVQPHSGSQANQAVYASVLKPGDTILGMSLAHGGHLTHGASVNISGKLYNAVTYGLDENEVLDYAEVERLALEHKPKMIVAGASAYALQIDWAKFREIADKVGAYLFVDMAHYAGLVAGGEYPNPVPFCDFVTTTTHKTLRGPRGGVILCRDNTHEKALNSSIFPSLQGGPLMHVIAAKAVAFKEALQPEFKQYAKQVKINAAVMAEELVKRGLRIVSGRTESHVFLVDLQPMKITGKAAEAALGKAHITVNKNAIPNDPEKPFVTSGIRIGSAAMTTRGFNETDARVLSNLVADVLANPEDEANLAKVRGQVTALCDKYPVYGT
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_CHLSY
Sequence: MALEKEEKSQIINGYQIHETDTGSPEVQVALLTERINQLIEHLRVHTHDHHSRRGLLKLVGRRRRLLNYLQSKDRERYRNVINRLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: AOX3_SOYBN
Sequence: MKNVLVRSAARALLGGGGRSYYRQLSTAAIVEQRHQHGGGAFGSFHLRRMSTLPEVKDQHSEEKKNEVNGTSNAVVTSYWGITRPKVRREDGTEWPWNCFMPWDSYHSDVSIDVTKHHTPKSLTDKVAFRAVKFLRVLSDIYFKERYGCHAMMLETIAAVPGMVGGMLLHLKSLRKFQHSGGWIKALLEEAENERMHLMTMVELVKPSWHERLLIFTAQGVFFNAFFVFYLLSPKAAHRFVGYLEEEAVISYTQHLNAIESGKVENVPAPAIAIDYWRLPKDATLKDVVTVIRADEAHHRDVNHFASDIHHQGKELKEAPAPIGYH
What is the function of this protein?
Catalyzes the cyanide-resistant oxidation of ubiquinol and the reduction of molecular oxygen to water, but does not translocate protons and consequently is not linked to oxidative phosphorylation.  May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures (By similarity).
What are the official names of this protein?
Alternative oxidase 3, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the alternative oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mitochondrial, possibly in the inner surface of the inner mitochondrial membrane.
Protein: MURC_RHOE4
Sequence: MTALPAHLERVHMVGIGGAGMSGIARILLSRGGLVSGSDAKESRGVLALRARGAQVRIGHDADALDLLPGGPTVVVTTHAAIPKDNPELVEAARRGIPVILRPAVLASLMQGNRTFLVSGTHGKTSTTSMLVVALQHCGFDPSFAVGGELNEAGTNAHHGSGDVFVAEADESDGSLLQYDPNVIVVTNIEADHLDYFGSVEAYVKVFDDFVDKLRPGGLLIACLDDPGSADLAKRIVASGRSDIRVLGYGSADAQEVEAGTAFEPVDGVEVGVRLLGFHAHDVGGVLQFQLAGENAARTVRMAVPGRHMALNALAALLAARDAGAETEEIVEGLAGFGGVHRRFQFTGRERGVRVFDDYAHHPTEVRAVLGAAADLVRPEDDSSSTNSAAGRVIVVFQPHLYSRTAAFAVEFAQALDLADEVVVLDVYGAREEPMPGVSGALVAQSVTKPVHYQPDLSQAPKQVAALAHPGDIVITMGAGDVTMLGKQILDALRSAPHPAPR
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBPA_STRCO
Sequence: MSERALRGTRLVVTSYETDRGIDLAPRQAVEYACEKGHRFEMPFSVEAEIPPEWECKVCGAQALLVDGDGPEEKKAKPARTHWDMLMERRTREELEEVLEERLAVLRSGAMNIAVHPRDSRKSA
What is the function of this protein?
Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.  Stimulates transcription from several principal sigma factor HrdB (SigA)-dependent promoters but not from a SigR-dependent promoter.  Stimulation occurs in the presence of the transcription initiation inhibitor rifampicin (Rif).
What are the official names of this protein?
RNA polymerase-binding protein RbpA.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase-binding protein RbpA family.
Protein: NUOK_RHOPB
Sequence: MTGTALTGMMIVAAGLFAAGVFGVLARRGILFQLISLEVALSGPALAFIAAGAYHGDAEGQGMFVLVLTLAAAEVAVGLALFLRIRRSKGSDDSDAVSGLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RUVA_CAMC5
Sequence: MIRAIEGIITKKEPAFVVLKTAGGVSYGLFISLFCSAKLSKGEKVELNTTQIIREDANLLYGFLDTNEQKMFEMLIKLNGIGASTAMAICSSLSPNAFSNAVINGDADTFKSVPGIGPKTARRIIAELSDAKLISDESVPGYQNEALLALEALGFKREKIVKILPDLKSTSTSELVKEALKKLA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: TAL_STRPG
Sequence: MKFFLDTANVAAIKAINELGVVDGVTTNPTIISREGRDFETVIKEICDIVDGPISAEVTGLTADAMVEEARSIAKWHDNVVVKIPMTTEGLKATNILSKEGIKTNVTLIFTVSQGLMAMKAGATYISPFIGRLEDIGTDAYQLISDLREIIDLYDFQAEIIAASIRTTAHVEAVAKLGAHIATIPDPLFAKMTQHPLTTNGLKTFMEDWASFKK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_STAA2
Sequence: MNLKQEVESRKTFAIISHPDAGKTTLTEKLLYFSGAIREAGTVKGKKTGKFATSDWMKVEQERGISVTSSVMQFDYDDYKINILDTPGHEDFSEDTYRTLMAVDSAVMVIDCAKGIEPQTLKLFKVCKMRGIPIFTFINKLDRVGKEPFELLDEIEETLNIETYPMNWPIGMGQSFFGIIDRKSKTIEPFRDEENILHLNDDFELEEDHAITNDSAFEQAIEELMLVEEAGEAFDNDALLSGDLTPVFFGSALANFGVQNFLNAYVDFAPMPNARQTKEDVEVSPFDDSFSGFIFKIQANMDPKHRDRIAFMRVVSGAFERGMDVTLQRTNKKQKITRSTSFMADDKETVNHAVAGDIIGLYDTGNYQIGDTLVGGKQTYSFQDLPQFTPEIFMKVSAKNVMKQKHFHKGIEQLVQEGAIQYYKTLHTNQIILGAVGQLQFEVFEHRMKNEYNVDVVMEPVGRKIARWIENEDQITDKMNTSRSILVKDRYDDLVFLFENEFATRWFEEKFLEIKLYSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VE2_HPV07
Sequence: MEKLARRLDLCQEQLLELYEQDSKQLQHHILHWKYIRYESVIYYTARQMGIKRLGHQVVPSLDVSKAKAHAAIEMQMCLESLQTTEYNLEPWTLQDTSQELWLAEPKKCFKKGGKTVEVRFDCNEHNAMHYTLWTAVYVQVEDTWTKVEGQVDHRGLFYTVHGCTTYYVDFGKEAHTYGKTNDWTVIVGSRVICSPSTVEGLPIVAPVDIRHPAATDATDATKVHDAPYALPASTTKVYNDSHAPPRKRRRDGDLSISAVDGCSGRKYVDTGNRARSPDIESNNKIRNSGGGHSTPIIQLEGDANCLKCFRYRLTKVSHLYTNSSTTWRWTTESRTNKNAIITLTYSSVHQRSQFLALVKIPKTIKHSLGMLTIM
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: MDM12_COPC7
Sequence: MSIDLEWAKLDSSLANYLVDVLNRQLSNAQRPSFIGPVEVTSLEFGSASPDVELVDLRDIYRDFLEDDEDDSSTSPVKVTEGQLDAHGGEDDDGYEWVPRRAAAREYYTEGGGHGGNGSHLPMHLRHPPLRSSPTDTFSSLGHSMGMTMPVGLDMWTGHGALFHHQGSGGSPALAHGGPILRSPSPSTPFPVVHTPPLGRTPTAAYRSSSALDPDSSFLNQPVFPSQQPQQQQPQQENNHPNLQLHLQVNWHSNLRITITTSLLINYPSPMFMSLPIKLSVTGLVFNGELAVAYEGQRRRVHVCILDDLDPYGPAGDRPKREVDPDTLNDTAITPPDLDEDSPPNSGRPQKPLPIGQRLLPSIFIESEIGQADKHVLKNVTRVERFIQDVIRKTVEEELVFPNFHTLVMGDG
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.  The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component MDM12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: LIPA_HAHCH
Sequence: MSETNVQGSLAEAPKAAVKRVEQGVKLRGYDKVSRNPVKIIATDAVPRKPDWIRVRLSSSPSVEAIKQKLRKLNLHSVCEEASCPNLSECFSHGTATFMIMGDICTRRCPFCDVAHGRPNALDENEPTHLAQAIAEMNLKYVVITSVDRDDLRDGGAGHFAKCISESRKYSPNLKIEVLVPDFRGRMDVALDILRESPPDVFNHNLETVPRLYKQARPGADYAWSLLLLKRFKEAAPDVPTKSGLMLGIGEEIEEVKQVMRDLRAHNTDMLTLGQYLAPSKDHLPVVRFVHPDEFKELADYGYEIGFKQVASGPLVRSSYHADKQAAGETIS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_BACVZ
Sequence: MFNLRDSEKLFIPFITAGDPLPDISVELAISLQNAGASALEIGVPYTDPLADGPVIQRASKRALENGMNIVKAIELGGKMKKNGVHIPIILFTYYNPVLQLEKEYFFALLRENDIDGLLVPDLPLEESALLQMTCKKENIAYISLVAPTSEDRLKIITEQACGFVYCVSSLGVTGVRSEFDPSVYSFIRKVKEFSSVPVAVGFGISNRKQVDGMNEISDGVVVGSALVKKIEELKTKLVNPGTRADALLEFEEYAKTFGRLYSVK
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: HEM1_ALISL
Sequence: MSLLVIGINHTSATVDLREKVAFSPDKLTKALDELKNSDAIKSGVILSTCNRTEIYCEVKLGISSGYVINWLAEFHHVALDLLMPSIYIYEEQAAVKHLMRVSCGLDSLVLGEPQILGQVKKAFADAREHNAVEGVVEKLFQSDFSVAKRVRTETNIGGNAVSVAYAACTLARQIFESLAESTVMLVGAGETIELVAKHLNDAGCKQLIVANRTRERAMILADQFNADVISLPEIPEHLSKADIIISSTASPLPIIGKGMVESALKQRRHQPMLFVDIAVPRDIESEVADLNDVYLYSVDDLKSIIDHNIEQRKIEAIQAEAIVSEESAGFMTWIRSRQAVNSIRQYRENSESIRIELLQKSIQALASGQNAEKVLAELSNKLTNKLIHAPTLAMQQAAKNGEPDKLAVIRTSIGLDN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: AT1A1_RHIMB
Sequence: MGYGAGRDKYEPAATSEHGGKKGKGKGKDRDMEELKKEVTMEDHKMTLEELHRKYGTDLTRGLTTARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIRKASDLEPDNDNLYLGVVLSAVVIITGCFSYYQEAKSSRIMESFKNMVPQQALVIRNGEKLSINAENVVQGDLVEVKGGDRIPADLRIISAHGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEGGQTPIAVEIGHFIHIITGVAVFLGVSFFILSLILHYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGASFDKSSPTWTALARIAGLCNRAVFPAGQENTPILKRDVVGDASESALLKCIELCCGSVKDMREKNQKVAEIPFNSTNKYQLSVHKNANPSESRYLLVMKGAPERILDRCSSILLQGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLDDEQFPDGFSFDTEDVNFPTEGLCFVGLISMIDPPRAAVPDRVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVIHGTDLKDMNADQIDDILRHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIADIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKKDKLVNERLISMAYGQIGMIQALGGFFAYFVILAENGFLPSTLLGIRVAWEDRYVNDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPTWWFCAFPYSLLIFIYDEVRKLILRRSPGGWVEKETYY
What is the function of this protein?
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane.  This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Multi-pass membrane protein.
Protein: THIK_ECO45
Sequence: MPFRSNNPLTRDELLSRFFPQFHPVTTFNSGLSGGSFLIEHQGQRFVVRQPHDPDAPQSAFLRQYRALSQLPACIAPKPHLYLRDWMVVDYLPGEVKTYLPDTNELAGLLYYLHQQPRFGWRITLLPLLELYWQQSDPARRTVGWLRMLKRLRKAREPRLLRLSPLHMDVHAGNLVHSASGLKLIDWEYAGDGDIALELAAVWVENIDQHRQLVNDYATRAKIYPAQLWRQVRRWFPWLLMLKAGWFEYRWRQTGDQQFIRLADDTWRQLLIKQ
What is the function of this protein?
Catalyzes the phosphorylation of thiamine to thiamine phosphate.
What are the official names of this protein?
Thiamine kinase.
What is the protein family that this protein belongs to?
Belongs to the thiamine kinase family.