PharMolix/UniProtQA huggingface dataset:
Protein: H3A01_CYRHA
Sequence: MKASMFLALAGLVLLFVVGYASESEEKEFPRELLSKIFAVDDFKGEERGCKGFGDSCTPGKNECCPNYACSSKHKWCKVYLGK
What is the function of this protein?
Selective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC(50)=1270 nM on Nav1. 1/SCN1A, 270 nM on Nav1. 2/SCN2A, 491 nM on Nav1. 3/SCN3A and 232 nM on Nav1. 7/SCN9A).  This toxin suppress Nav1. 7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics.  Short extreme depolarizations partially activate the toxin-bound channel, indicating voltage-dependent inhibition of this toxin.  This toxin increases the deactivation of the Nav1. 7 current after extreme depolarizations.  The toxin-Nav1. 7 complex is gradually dissociated upon prolonged strong depolarizations in a voltage-dependent manner, and the unbound toxin rebinds to Nav1. 7 after a long repolarization.  Moreover, analysis of chimeric channels showed that the DIIS3-S4 linker is critical for toxin binding to Nav1. 7.  These data are consistent with this toxin interacting with Nav1. 7 site 4 and trapping the domain II voltage sensor in the closed state.
What are the official names of this protein?
Hainantoxin-III 1, HnTx-III, Hainantoxin-3, Mu-theraphotoxin-Hhn2a, Mu-TRTX-Hhn2a, Peptide F7-18.76.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 15 (Hntx-3) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YHCH_BACSU
Sequence: MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKTTTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFARMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPTNGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVKDENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIRIYEVKVITKSLEDRFLEMTGETKEEVQHA
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein YhcH.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: NDK_SALEP
Sequence: MAIERTFSIIKPNAVAKNVIGSIFARFEAAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLESENAVQRHRDLLGATNPANALAGTLRADYADSLTENGTHGSDSLESAQREIAFFFGEGEVCPRTR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM17A_XENTR
Sequence: MAQAAGVRRQLDSLTRNIFLRDVGRTVPEKSGAPLTGDSEVAPSVSLQIFLYFNAFYFPFWWVCYVIMLQLKYVLLPDYYKFILVVLLILMSVIEVIRLYLGYSGNLQEKVPELAGFCLLSILLQLPLLLFLLCDPGLEPLPLERAVHGILTAFLLIQIPISIFALRKATRHLAGRFHLLGDLDGRA
What is the function of this protein?
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.  Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).
What are the official names of this protein?
Transmembrane protein 17A.
What is the protein family that this protein belongs to?
Belongs to the TMEM17 family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Multi-pass membrane protein. Note=Localizes to the transition zone of primary cilia.
Protein: ECPA_ECO27
Sequence: MKKKVLAIALVTVFTGTGVAQAADVTAQAVATWSATAKKDTTSKLVVTPLGSLAFQYAEGIKGFNSQKGLFDVAIEGDSTATAFKLTSRLITNTLTQLDTSGSTLNVGVDYNGAAVEKTGDTVMIDTANGVLGGNLSPLANGYNASNRTTAQDGFTFSIISGTTNGTTAVTDYSTLPEGIWSGDVSVQFDATWTS
What is the function of this protein?
Part of the ecpRABCDE operon, which encodes the E. coli common pilus (ECP).  ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition.  Major subunit of the fimbria (By similarity).
What are the official names of this protein?
Common pilus major fimbrillin subunit EcpA, MatB fimbrillin.
What is the protein family that this protein belongs to?
Belongs to the EcpA/MatB fimbrillin family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: FAPD_BACSU
Sequence: MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQSWIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWKHDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGEAGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGGGTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADECRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIFPALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHNAHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ
What is the function of this protein?
Catalyzes the deformylation of the formylaminopyrimidine N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine (FAMP) to give the corresponding aminopyrimidine.
What are the official names of this protein?
N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase, Formylaminopyrimidine deformylase, Amidohydrolase YlmB.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: CKI3_SCHPO
Sequence: MSTTSSHSNVVGVHYRVGKKIGEGSFGMLFQGVNLINNQPIALKFESRKSEVPQLRDEYLTYKLLMGLPGIPSVYYYGQEGMYNLLVMDLLGPSLEDLFDYCGRRFSPKTVAMIAKQMITRIQSVHERHFIYRDIKPDNFLIGFPGSKTENVIYAVDFGMAKQYRDPKTHVHRPYNEHKSLSGTARYMSINTHLGREQSRRDDLESMGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQVTPLKELCEGYPKEFLQYMIYARNLGYEEAPDYDYLRSLFDSLLLRINETDDGKYDWTLLNNGKGWQYSAAKQHVVQRRHTQGTNNRRQSTIPPYARTRQNLLSSPSKQTPVNNVVDASVATQKDGIPGKAASPQVQQQQQTSSAQQQQPQRVEQPAPQTTQPTQVDTQQAAKPAPSKEKSRKKFHLRLLSCCISKQE
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
What are the official names of this protein?
Casein kinase I homolog 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_BACC7
Sequence: MTKWFNVGKIVNTHGVKGEIRVVSRTDFPEERYKVGNTLYISNEKGGEPFPVKITSHRQHKTFDLLTFEGYGNVNEVEQFKGSLLKVPEDQLGELAEGEYYYHEIIGCNVVTEEGEALGTIKEVLSPGANDVWVIKRPKGQDLLIPYIDDVVLQVNIENKLVTIHVMEGLL
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_DICTD
Sequence: MITIGIETSCDETSVSLLEDGNKILSNLVSSQVEIHKTFGGVVPEVASRIHVEVLNRLIELALEKAKKEFTDIDLIAVTQGPGLIGALWIGIMAAKTLSLALNKPLIGVNHLEGHIFANFLGEDPPTFPFIALIVSGGHTEYILVEDIGVYKILGQTLDDAAGEAFDKVARILGLNYPGGPEIDKISKMGKPIFNFPKIKCDRELDISFSGIKTAVLYLVRDLKKEGKEIPVADIAASFQERVVEELLERAFLALNKFNIKTLVVSGGVASNSYLQRRFKEESRKEGIKLYIPPPYLCTDNGAMIACAGYHLYQKGYKSDLYLSANPDLLLGER
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_LYSSC
Sequence: MSKVPSLIEELAKPIVDELNLELVDIEFVKEGRNWFLRVYVDTPEGGIDIDQCAQVSERLSLLLDEKDPITQNYYLEVSSPGAERPLKKDADFEKAIGKFIYVKTYKPIKDMKEFQGYLTSYEEHTLVMEVRIKTRKITVTIEQEKIALARLAIDF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNE_SHEFN
Sequence: MQNQGNKVLSAAMLDSADRYWLRLCDVWPEAKTALTAMQQQELTAVFGLSDYMGEQLCRHPEWIVQLFDGLLDDVVRSEFDAQLHSLIADLTQEELVKSALRRYRNLQMVRLAWRDFLNYTPVEESLLDLSALAEALVIAGRDWLYQEMCQQYGTPTSAEGNPQPLLILGMGKLGGRELNFSSDIDLIFTFPEHGETVGGRRTQANQQFFIRMGQRLVNLLDQVTVDGFVFRVDMRLRPYGESGPLVVSFSGLEDYYQEQGRDWERYAMVKARVLGPWSGYCDELHDLLRPFVYRRYIDFSAIESLRKMKQLIAQEVRRRQLTDNIKLGAGGIREVEFVVQSFQLIRGGREPALRQQSLFGAIDTLYSLGQLEYLAVDELKHSYIILRRVENLLQAIDDKQTQTLPNNELDWQRLCYPLDMADEVELRQKINQAMVTIHGHFNATVGGTDSHEHNDHWTALFWNVQQDEHANALLQEQQVDDAELWQLLSEWRQTVSKRSIGPRGRETLDKLMPKLLEELVTQTKPSQAFKPVAKVLDKILTRTTYLELLCENPGARQQLVSLCCASPWIARELANFPMLLDELIDPSQLYDITSIDDYPSELRQYLLRVPEDDMEQQMEALRQFKLSQQLKIAAADVTGVLPVMQVSDHLTFLAEAIIEQVVLQAWHQVASRHGIPAETSPSNMGFAVIGYGKLGGIELGYGSDLDLVFLHGHTGSGTTDGKRPIDNGHFYLKLAQRIVHLFATRTTSGELYEVDMRLRPSGASGLLVSEIEHFGAYLQQEAWTWEHQALVRSRFVFGDYSLAGRFSDLRAQVLKIERDKQVLAKAVKDMRIKMREHLLQVEPGQFDLKQSAGGIADIEFIAQYLVLANAHQYHELTIWSDNVRIFEVLAELELLPIMQAQHLTQTYCWLRDENHELTLQQLPGKLPIQSVLQKTDSVIEIYNEILAI
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: TRMJ_ECOL5
Sequence: MLQNIRIVLVETSHTGNMGSVARAMKTMGLTNLWLVNPLVKPDSQAIALAAGASDVIGNAHIVDTLDEALAGCSLVVGTSARSRTLPWPILDPRECGLKSVAEAANTPVALVFGRERVGLTNEELQKCHYHVAIAANPEYSSLNLAMAVQVIAYEVRMAWLATQENGEQVEHEETPYPLVDDLERFYGHLEQTLLATGFIRENHPGQVMNKLRRLFTRARPESQELNILRGILASIEQQNKGNKAE
What is the function of this protein?
Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
What are the official names of this protein?
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ, tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase, tRNA Cm32/Um32 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_BACAA
Sequence: MKVLQEKILNEGKVLSGDVLKVDAFLNHQIDPVLMQEIGKEFAKRFKEENITKIVTIESSGIAPAVMAALELGVKVIFARKRKSLTLQDNMYVANVYSFTKQETNEISLSRNHIDESDRVLIIDDFLANGQAALGLMSLVEQAGASIAGIGIVIEKAFQDGGKKLREQGIRVESLAEIASLDNNAVTFVQQETAEVK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AREL1_HUMAN
Sequence: MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKSVTSNRQTFQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML
What is the function of this protein?
E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (PubMed:25752577).  E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:23479728, PubMed:31578312).  Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (PubMed:23479728).  Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312).
What are the official names of this protein?
Apoptosis-resistant E3 ubiquitin protein ligase 1, Apoptosis-resistant HECT-type E3 ubiquitin transferase 1.
Protein: RPOZ_SHEB5
Sequence: MARVTVEDAVEQIGNRFDMILVAARRARQIAVQGKDPMVEEMNDKPTVIALREIELGLVNAHTLDADERQTVREREAAEIAAVSAIAEGRSL
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: SURE_XYLFM
Sequence: MRVLVSNDDGVDAPGIKILADALRNAGHEVMVVAPDRDRSGASNSLTLDTPIRAKQIDMHTYSVAGTPTDCVHLALTGLLNYDPDIVVSGINNTGNLGDDVIYSGTVSAAMEGRFLGLPAVAVSLVTLCREGQQAPQYETAAHAAINIVAQLKTDPLPADTILNVNVPDVTWQQMRGFKVTRLGNRHRSAPCLTQTDPRGHTIYWIGPAGPEQDAGPGTDFDAVRNTYISITPIHVDLTRYQALENVTRWTDRLTAHMDWPT
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTA1_AJECA
Sequence: MSPESKKITAHGSTSMPLSRTSKPQKFTIPLTVGAIFSVIGFLQRFFLASGKGDVQSLYTLSTMFILGAGPTYAGADYFICGRLFSFVPSAAPMSPIRVVRTFITFDVLAEVCVWTGAGLLAGAHTDTAARYKIGLNLIRAAMITQAFLFTSFVAILASFHVRVCALRAEWSVTSNGGTGRRFMMVVHSLYASSIFIIIRSAYHIAGHSFRTNEQPFLICEASLMLLNTAMFNVFHPGHILPIDSRVYVGIDGQERANETIEGAFTDSRPLLQKILDPLDVKGLFSRDKKRWHDPTAELEMDINSTLYAALT
What is the function of this protein?
Lipid-translocating exporter-like protein; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence via intracellular iron acquisition during macrophage infection (PubMed:18404210).
What are the official names of this protein?
Lipid-translocating exporter-like protein RTA1, Siderophore biosynthesis cluster protein RTA1.
What is the protein family that this protein belongs to?
Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RIMM_ECOBW
Sequence: MSKQLTAQAPVDPIVLGKMGSSYGIRGWLRVFSSTEDAESIFDYQPWFIQKAGQWQQVQLESWKHHNQDMIIKLKGVDDRDAANLLTNCEIVVDSSQLPQLEEGDYYWKDLMGCQVVTTEGYDLGKVVDMMETGSNDVLVIKANLKDAFGIKERLVPFLDGQVIKKVDLTTRSIEVDWDPGF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCN1_MOUSE
Sequence: MSSSTFRTLAVAVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEEWVCDEDSIKDSLDDQDDLLGLDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLFNPLHAHGQKCIVQTTSWSQCSKSCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCSSVKKYRPKYCGSCVDGRCCTPLQTRTVKMRFRCEDGEMFSKNVMMIQSCKCNYNCPHPNEASFRLYSLFNDIHKFRD
What is the function of this protein?
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion.  Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity).  CCN1-mediated gene regulation is dependent on heparin-binding (By similarity).  Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity).  Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).
What are the official names of this protein?
CCN family member 1, 3CH61, Cellular communication network factor 1, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10, IBP-10, IGF-binding protein 10, IGFBP-10, Protein CYR61.
What is the protein family that this protein belongs to?
Belongs to the CCN family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACEK_BURP6
Sequence: MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERADWHGLQRLARERITSYDDRVRECVELLEDEYDAENIDNEVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGLAATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYVVGRIINGDRVLPFAVPIRHARAGILALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIVAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKDTTREQIMAKYLLVKRHDRLGRMADTLEYSSVALPLARLDDALVRELEKEVPSLIEYEGENLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELMQANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDSKDRLLRGELPDFFAYEPALRFCIRYPERFAPGDAADGGKLAAA
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y4EF_SINFN
Sequence: MLGREDIRTYQVYLANEKKLAPGSIHIALSALRFFFNVTLERDWAPEEVLPLPKKPQKLPIILSPDEVQHFLGCVADVKHHAILTTCYAAGLRISEAVQLKPTDIDSQRMVVRVEHGKGQKDRYVMLSPKLLEILRDYWRMWRPEAWLFPGDRAGHPITRYAVGQACVKPHDLSRLSKPVTPHSLRHAFVVHLLEAGADVRTIQPLLGHRSLATTAHYLRIATNKVCATESPFELLPRPAPTPPPSKPQYF
What are the official names of this protein?
Putative integrase/recombinase y4eF.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family.
Protein: PAFA_MYCTA
Sequence: MQRRIMGIETEFGVTCTFHGHRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATAECDSLVQLVTHDRAGEWVLEDLLVDAEQRLADEGIGGDIYLFKNNTDSAGNSYGCHENYLIVRAGEFSRISDVLLPFLVTRQLICGAGKVLQTPKAATYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAEKYRRLHVIVGDSNMSETTTMLKVGTAALVLEMIESGVAFRDFSLDNPIRAIREVSHDVTGRRPVRLAGGRQASALDIQREYYTRAVEHLQTREPNAQIEQVVDLWGRQLDAVESQDFAKVDTEIDWVIKRKLFQRYQDRYDMELSHPKIAQLDLAYHDIKRGRGIFDLLQRKGLAARVTTDEEIAEAVDQPPQTTRARLRGEFISAAQEAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVKRLIASM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: RS8_LACP7
Sequence: MTMSDPIADMLTRIRNANTAKHDTVDVPASKMKIAIAEILLKEGYIKSFEIEEVGSFKTIHITLKYGKDKNEKVITGLKRISKPGLRVYANSTELPRVLGGLGVAIISTNKGVLTDKAARNANVGGEVLAFIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: GPX1_RAT
Sequence: MSAARLSAVAQSTVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTTRDYTEMNDLQKRLGPRGLVVLGFPCNQFGHQENGKNEEILNSLKYVRPGGGFEPNFTLFEKCEVNGEKAHPLFTFLRNALPAPSDDPTALMTDPKYIIWSPVCRNDISWNFEKFLVGPDGVPVRRYSRRFRTIDIEPDIEALLSKQPSNP
What is the function of this protein?
Protects the hemoglobin in erythrocytes from oxidative breakdown.  In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism.
What are the official names of this protein?
Glutathione peroxidase 1, GPx-1, GSHPx-1, Cellular glutathione peroxidase.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_VERTH
Sequence: MEEIQRYLQLERSQQQHHFLYPLIFQEYIYVFAHDRGFSRSILSENRGYDNKSSFLLVKRLITRMYQQNHXIIFSNDSNQNLFWGRNKNLYSQILSEGFSFILEIPFSLRLISYLEGKKKKIVKSQNLRSIHSTFPFLEDNFSHLNFLLDILIPHSVHAEILVQTLRYWLKDASSLHLLRFFLNEYCNWNRLITPKKASSSFSKRNQRLFLFLYNYHVCEYESIFVFLRNQSSHLRSTSSGVFLERIYFYGKVERLVNVFGKVKDFQENLWLVKEPCMHYVRYQRKSXLASKGTSLLMNKWKCYLVTFWQWYFSLWFHPRRIYINQLSNHSLEFLGYLASVRMNPSVVRSQILENSFLINNAIKKFDTLVPIIPLIASLAKAKFCNLLGHPISKPVWXDLSDSNIIDRFGRICRNLSHYHSGSSKKKSLYRIKYILRFSCAXTLARKHKSTVRAFLKKLGSELLQEFLMSEEDVLSLTFPKASSTLRGVYSSRIWYLDIICINDLANLK
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS11_VIBCM
Sequence: MAKQPTRARKRVRKQVADGVAHIHASFNNTIVTITDRQGNALAWATAGGSGFRGSRKSTPFAAQVAAERCAEMAKEYGLKNLEVMVKGPGPGRESTVRALNAAGFRITNIVDATPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.