PharMolix/UniProtQA huggingface dataset:
Protein: TRUC_HAEDU
Sequence: MELDILYRDDELIAINKPAGMLVHRSWLDKAETLFAMQTLRDQINQHVFPIHRLDRPTSGVLLFALNSEMARLMSEQFEQHKVEKEYLAIVRGYIAEKGEIDYPLKVILDKIADKFSQPKAAQQAVTFYQNLAKVEMPYSTGKYATTRYSLVALSPKTGRKHQLRRHMKHLFHPIMGDTKYGDLHQNRRLTEKTGCNRLMLHARLLHFTHPKTLQKITISALLDQQWQMLFNQFGWHFTDFFY
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase C, tRNA pseudouridine(65) synthase, tRNA pseudouridylate synthase C, tRNA-uridine isomerase C.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RluA family.
Protein: ARLY_PARD8
Sequence: MAQKLWEKNVQVDHEVDIFTVGKDREMDLYLAKYDVLGSMAHITMLESIGLLTKEELNVLLAELRNIYAVADRGEFIIEEGIEDVHSQVELMLTRRLGDMGKKIHSGRSRNDQVLLDLKLFTRSQIQELVELVSGLFDVLISQSNRYKDVLLPGYTHLQVAMPSSFGLWFGAYAESLVDDLQLMQAAYRICNRNPLGSAAGYGSSFPLNRQMTTDLLGFDSLDYNVVYAQMGRGKMERTVAFAMAGIAATLSKLAFDACMFNSQNFGFIKLPDQFTTGSSIMPHKKNPDVFELTRAKCNKLQGLPQQIILISNNLPSGYFRDLQIIKEVFLPAFDELKDCLRMVTHMMREVKVNEHILDDDKYSLLFSVEEVNRRVLAGMPFRDAYKQVGLDIEAGKFIPSKSVNHTHEGSIGNLCNESITAMMRSVIGSFSFERMNEAEKKLIHG
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSDH_PONPY
Sequence: MATCFWLRSSGAQRLGSTFPGCRLRPRAGGLVPASRPAPGPAQLRGYAGGLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCSWREVSAKERSSLLRKWYXLMIXNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIYTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATIVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFNTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
What is the function of this protein?
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
What are the official names of this protein?
Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: VE1_HPV45
Sequence: MADPEGTDGEGTGCNGWFFVETIVEKKTGDVISDDEDETATDTGSDMVDFIDTQLSICEQAEQETAQALFHAQEVQNDAQVLHLLKRKFAGGSKENSPLGEQLSVDTDLSPRLQEISLNSGHKKAKRRLFTISDSGYGCSEVEAAETQVTVNTNAENGGSVHSTQSSGGDSSDNAENVDPHCSITELKELLQASNKKAAMLAVFKDIYGLSFTDLVRNFKSDKTTCTDWVMAIFGVNPTVAEGFKTLIKPATLYAHIQCLDCKWGVLILALLRYKCGKNRLTVAKGLSTLLHVPETCMLIEPPKLRSSVAALYWYRTGISNISEVSGDTPEWIQRLTIIQHGIDDSNFDLSDMVQWAFDNDLTDESDMAFQYAQLADCNSNAAAFLKSNCQAKYLKDCAVMCRHYKRAQKRQMNMSQWIKYRCSKIDEGGDWRPIVQFLRYQGVEFISFLRALKEFLKGTPKKNCILLYGPANTGKSYFGMSFIHFLQGAIISFVNSNSHFWLEPLADTKVAMLDDATHTCWTYFDNYMRNALDGNPISIDRKHKPLLQLKCPPILLTSNIDPAKDNKWPYLESRVTVFTFPHAFPFDKNGNPVYEINDKNWKCFFERTWSRLDLHEDDEDADTEGIPFGTFKCVTGQNTRPL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: CEDA1_SULAC
Sequence: MTLVTFIENLTSTVTEIGWSLFILAWAIGWALRGSPIPIFRIKRGGQDLLEDAIIAAFFLAIGSTIFYLISYIASQVS
What is the function of this protein?
Part of the Ced system, which is involved in DNA import.
What are the official names of this protein?
DNA import protein CedA1, Crenarchaeal system for exchange of DNA protein A1.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CEP1_LISFU
Sequence: SGQSWRPQGRF
What is the function of this protein?
Potentiates the beat of the ventricle, and has also excitatory actions on the penis retractor muscle, the buccal muscle and the identified neurons controlling the buccal muscle movement of achatina.
What are the official names of this protein?
Cardio-excitatory peptide 1, ACEP-1.
What are the subcellular locations of this protein?
Secreted.
Protein: RUTD_SHIF8
Sequence: MKLSLSSPPYADAPVVVLISGLGGSGSYWLPQLAVLEQEYQVVCYDQRGTGNNPDTLAEDYSIAQMAAELHQALVAAGIERYAVVGHALGALVGMQLALDYPASVTMLVSVNGWLRINAHTRRCFQVRERLLYSGGAQAWVEAQPLFLYPADWMAARAPRLEAEDALALAHFQGKNNLLRRLNALKRADFSHHADRIRRPVQIICASDDLLVPTACSSELHAALPDSQKMVMPYGGHACNVTDPETFNALLLNGLASLLHHREAAL
What is the function of this protein?
Involved in pyrimidine catabolism.  May facilitate the hydrolysis of carbamate, a reaction that can also occur spontaneously.
What are the official names of this protein?
Putative carbamate hydrolase RutD, Aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Hydrolase RutD family.
Protein: RL14_VIBC3
Sequence: MIQMQTMLDAADNSGARSVMCIKVLGGSHRRYAHVGDIIKVTVKEAIPRGKVKKGDVLKAVVVRTRKGVRRPDGSVIRFDRNACVLLNNNSEQPIGTRIFGPVTRELRNAKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: DLHH_SYNY3
Sequence: MTVDIKTTLVTIPNQNLQIAGYLAEPVAVGQYPVVIVIQEIFGVNSHIRDVTERVAKEGYVAIAPAIYQRQAPGFEEGYTPEGIEAGRKLKDQTSSAEILSDLEATIAYAQTLPNVKPEEVGLIGFCFGGWIVYLGASLPTVKATASFYGAGIPHWAPGTAEPPITYTDKIQGTLYAFFGLEDTSIPMADTEQIEQALTKYQVNHKIFRYPGADHGFFCDQRASYNAEAAADAWQKVKQLFQTELK
What are the official names of this protein?
Putative carboxymethylenebutenolidase, Dienelactone hydrolase, DLH.
What is the protein family that this protein belongs to?
Belongs to the dienelactone hydrolase family.
Protein: PIP_MOUSE
Sequence: MQGLSFTFSAVTLFLVLCLQLGIIESQDDENVRKPLLIEIDVPSTAQENQEITVQVTVETQYRECMVIKAYLVSNEPMEGAFNYVQTRCLCNDHPIRFFWDIIITRTVTFATVIDIVREKNICPNDMAVVPITANRYYTYNTVRMN
What are the official names of this protein?
Prolactin-inducible protein homolog, 14 kDa submandibular gland protein, SMGP, Gross cystic disease fluid protein 15, GCDFP-15, Prolactin-induced protein.
What is the protein family that this protein belongs to?
Belongs to the PIP family.
What are the subcellular locations of this protein?
Secreted.
Protein: CHSA_IPONI
Sequence: MSTILTNTWTRREKRIEGHAKILAIGTAIPANWVDQTTYPDFYFRITNSEHLLEHKEKFRRICNKSKIRKRHLVITEELLKKNPNLCTYNEASLNTRQDILVSEVPKLGKEAAMKAIKEWGRPISEITHLVFCTSSGVDMPGADFQLAKLLGLSSSVNRLMMYQQGCNAGAAMLRLAKDLAENNKGGRVLVVCSEVMLNVFRGPSLEQEDYLLAQCLFGDGSAAVIVGTEPRPGLETPLFELVSAAQTTIPDTDSHLKLHLREMGLTFHCSKAVPSLITQNVEDYLVKAFEPFGISDWNSIFWILHPGGIAILDRVEEKLGLEPEKLRASRDVLSESGNLTSAC
What is the function of this protein?
The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.
What are the official names of this protein?
Chalcone synthase A, Naringenin-chalcone synthase A, CHS-A.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: FB226_ARATH
Sequence: MDRIIGLPDEVLVKILSFVPTKVAVSTSILSKRWEFLWMWLTKLKFGSKRYSESEFKRLQCFLDRNLPLHRAPVIESFRLVLSDSHFKPEDIRMWVVVAVSRYIRELKIYSSHYGEKQNILPSSLYTCKSLVILKLDGGVLLDVPRMVCLPSLKTLELKGVRYFKQGSLQRLLCNCPVLEDLFVLLLRCDDIGMFIVIVPSLQRLSLYLSPRCNLEGFVIVLDTPLEYFKLVDRNYDRHPYMIENMPKLTSAYVEVISADLKSLVESITSVKYLTIFSENYDDFVFPWNQPSTVPKCFCPVYKSSPVYKSSPGQNT
What are the official names of this protein?
F-box protein At4g09920.
Protein: ALF1_SCHPO
Sequence: MDSDLDRILPIASRALLCEGNRDWAGAYVSYCKVLEEMKKSSAARDRMGLGPLTGAEACSWNGLYDNCLSKASKLRKTILESEMERQNYQLAAKLSKKAPVDLHPLRPVRSQTPAYTPMTTRMMYRQTRGAQSEVNLSTPKQIYSKHSPPSTSTSSIVSSSYGDAPSYLAPSKPNRSPPLKPEDPFASFNSSASAIAAASKSAAASASALSSDTGRSATMNSTTFPTAMKSQSTTKPTLSNSVSSPSIQVSNNQNANNSTPLSFHAPIPPLHVPAVPLTSASHSSSDGKSRKHPSPYKPYLNSSHDTLGSSTRPSSADTAGSPATSPPATADSKTIVSKTISASTTQQTEPLQQTTPSSDFEYAIMNEIISNHEPVYWSDIAGLDDAKNSLKEAVIYPFLRPELFQGLREPVQGMLLFGPPGTGKTMLARAVATEAKATFFSISASSLTSKYLGDSEKLVRALFEVAKRQTCSVIFVDEIDSILSARNDSGNEHESSRRLKTEFLIQWSSLTNAAPDKQTGHSPRVLVLAATNLPWCIDEAARRRFVKRTYIPLPEKETRYKHLSHLLHNQVHCLTEEDLEELVNLTEGYSGSDITALAKDAAMGPLRNLGDALLTTSAEMIPPISLNHFKASLRTIRPSVSQEGIHRYEEWNKQFGSQR
What are the official names of this protein?
ATPase-like fidgetin, Protein sur2.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KMT5A_HUMAN
Sequence: MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAAAAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
What is the function of this protein?
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:17707234, PubMed:27338793).  Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:27338793, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599).  H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599).  Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599).  Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599).  Involved in chromosome condensation and proper cytokinesis (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599).  Nucleosomes are preferred as substrate compared to free histones (PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:15200950, PubMed:15933069, PubMed:15933070, PubMed:16517599).  Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (PubMed:17707234).  Plays a negative role in TGF-beta response regulation and a positive role in cell migration (PubMed:23478445).
What are the official names of this protein?
N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, Histone-lysine N-methyltransferase KMT5A, Lysine N-methyltransferase 5A, Lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7, PR/SET07, SET domain-containing protein 8.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes (PubMed:12208845). Colocalized with SIRT2 at mitotic foci (PubMed:23468428). Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress- dependent manner (PubMed:23468428). Associates with silent chromatin on euchromatic arms (PubMed:12086618). Not associated with constitutive heterochromatin (PubMed:12086618).
Protein: FTSH_PORPU
Sequence: MKLSWKTLLLWSLPIFVVGFFFWQGFLGPTTTDVGSNIASSRMTYGRFLEYLDMGWVKRVDLYENNHTAIVEAVGPELGNRVQRIRVELPASAPELITKLRKANVDLDAHPPKSTSAVWGLLGNLLFPLILVGGLAFLFRRSNNASGGPGQAMSFGKSKALFQMEAKTGVVFNDVAGVEEAKEEFQEVVTFLKQPESFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFKKAKDNAPCIVFIDEIDAVGRQRGTGVGGGNDEREQTLNQLLTEMDGFEGNTGVIVIAATNRADILDSALLRPGRFDRQVSVDVPDFRGRLAILEVHAKNKKMESKVSLETIARRTPGFSGADLANLLNEAAILTARRRKSAMTMSEIDTSIDRVVAGLEGTPLIDSKSKRLIAYHEVGHAIIGSLLEHHDPVQKVTLIPRGQARGLTWFTPSDDQSLISRSQILARIVGALGGRAAEEIIFGDAEVTTGASNDLQQVTSMARQMVTRFGMSKIGPLSLESQGSDPFLGRGMGGGSEYSDEVATNIDKQVREIVSECYKEAKKIVKDNRVVMDRLVDLLIEKETIEGNEFRHIVKEYTAIPEKNYYISQF
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein; Stromal side.
Protein: ULAF_ECOK1
Sequence: MQKLKQQVFEANMELPRYGLVTFTWGNVSAIDRERGLVVIKPSGVAYETMKADDMVVVDMSGNVVEGEYRPSSDTATHLELYRRYPSLGGIVHTHSTHATAWAQAGLAIPALGTTHADYFFGDIPCTRGLSKEEVQGEYELNTGKVIIETLGDAEPLHTPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVAKMAWIARSINPQLNHIDSFLMNKHFMRKHGPNAYYGQK
What is the function of this protein?
Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 4-epimerase UlaF, L-ascorbate utilization protein F, Phosphoribulose isomerase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. AraD/FucA subfamily.
Protein: HEM1_MYCBO
Sequence: MSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEAMVLSTCNRVEVYAVVDAFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYAVAESNRTVGRVLHELAQRALSVGKRVHSETAIDAAGASVVSVALGMAERKLGSLAGTTAVVIGAGAMGALSAVHLTRAGVGHIQVLNRSLSRAQRLARRIRESGVPAEALALDRLANVLADADVVVSCTGAVRPVVSLADVHHALAAARRDEATRPLVICDLGMPRDVDPAVARLPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAAEVASYLVGQRMAEVTPTVTALRQRAAEVVEAELLRLDNRLPGLQSVQREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVATAGELPVVPSGFDAESRRGGGDMQSSPKRSPSN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: Y4531_RHIME
Sequence: MGSAKDKVAGKANELAGKAKKAAGDATDNNSLRAKGAAQEAKGGAQQAKGKLKDAVKGAVDKT
What are the official names of this protein?
UPF0337 protein RA1131.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: RL24_BACC3
Sequence: MHVKKGDKVQVITGKDKGKQGVILVAFPKQNRVIVEGVNIVKKHSKPSQLNPQGGIITKEAPIHVSNVMILDPKTGEPTRVGFKVEDGKKVRIAKKSGELLDK
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CSM2_CANGA
Sequence: MPPKRYDDLSLLTLWPVAPDIDLAQYIYQFLTSEVGTQTEKEVYFTDSINSFPIHQLQELVNESNQSIYENIKINTALDLHELSSIIKKNTESLILKKIQNKKTNDLKPFQILSVINGLDVMFRSTLVSFTNEQAHLMLRDVMLRLRQVCNEYDCSPLTFKIILLFNRSDVMELLPKQRHSAAHQQKKMKYNNAMEGNSVGEFVGKYYCDEVAQ
What is the function of this protein?
Involved in chromosome segregation during meiosis.  Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs) (By similarity).
What are the official names of this protein?
Chromosome segregation in meiosis protein 2.
What is the protein family that this protein belongs to?
Belongs to the CSM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CH60_WOLTR
Sequence: MTNVVVSGEQLQEAFREVAVMVDSTVAITAGPRGKTVGINKPYGAPEITKDGYKVMKGIKPEKPLHAAITSIFAQSCFQCNDKVGDGTTTCSILTSNMIMEALKSIAAGNDRVSIKNGMQKAKDAVLEGITSMSRTIPLEKMDEVAQVAIISANGDKDIGNSIADAVKKVGKEGVITVEESKGSKELEVELTTGMQFDRGYLSPYFITSNEKMIVEFDDPYLLITEKKLSIIQPLLPILEAVVKSGKPLLIIAEDIEGEALSTLVINKLRGGLKVTAVKAPGFGDRRKEMLEDIAALTGAKYVIKDELGIKMEDLTLEDLGTAKNVKVTKDNTTIVSGSSDSDRVKARVEQIKSQIETSTSDYDKEKLRERLAKLSGGVAVLKVGGVTEVEVKERRDRVEDALHATRAAIEEGIVPGGGVALLYASSALDKLKGGSDEEQIGINIIKKVLSAPIKRLVKNAGLESAVIIDHLTKQNDKELIYNVEAMNYANAFTAGVIDPAKVVRIAFETAISVASVLITTESMIVDVPNKEENASSSMGAGGMGGMNGF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7S_BURO0
Sequence: MAKTASPGATPPGNGTEPLPDNYEMALAELETLVARMEGGALSLEDSLAAYRRGATLVAFCQQQLEKVEQQVRVLDGATLKPLSSGTAATDGEDDDL
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
Protein: ENO_ECOL5
Sequence: MSKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVAAVNGPIAQALIGKDAKDQAGIDKIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKTVKEAIRMGSEVFHHLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: ENV_FIVWO
Sequence: MAEGFAANRQWIGPEEAEELLDFDIAIQMNEEGPLNPGVNPFRVPGITEAEKQEYCNILQPKLQDLKGKIQEVKLEEGNAGKFRRARFLRYSDETVLSLIHLFIGYCPHLCRRHELGSLRHDIDIEALQEERYNDREKGITDNIKYGKRCLIGTAVLYLLLSLGIIIHTCKAQVVWRLPPLVVPVEESEIIFWDCWAPEEPACQDFLGAMIHLKASTNISIQEGPTLGNWAREIWGTLFKKATRQCRRGRIWRRWNETITGPLGCANNTCYNISVIVPDYQCYLDRVDTWLQGKVNISLCLTGGKMLYNKETKQLSYCTDPLQIPLINYTFGPNQTCMWNTSQIQDPEIPKCGWWNQNAYYNSCRWEHTDVQFQCQRTQSQPGSWIRAISSWKQRNRWEWRPDFESEKVKVSLQCNSTKNLTFAMRSSGDYGEVTGAWIEFGCHRTKSKYHTEARFRIRCRWNVGDNTSLIDTCGETQNVSRANPVDCTMYANRMYNCSLQNGFTMKVDDLIMHFNKTKAVEMYNIAGNWSCKSDLPPTWGYMNCNCTNSTNSGTGIRMACPRNQGILRNWYNPVAGLRQSLEKYQVVKQPDYLVVPGEVMEYKPRRKRAAIHVMLALATVLSMAGAGTGATAIGMVTQYQQVLATHQEAIEKVTEALKINNLRLVTLEHQVLVIGLKVEAMEKFLYTAFAMQELGCNQNQFFCKVPSALWERYNMTINQTIWNHGNITLGEWYNQTKDLQQRFYEIIMDIEQNNVQGKKGLQQLQEWEDWVGWIGNIPQYLKGLLGGILGIGLGMLLLILCLPTLVDCIRNCIHKILGYTVIAMPEVEEEEIQPQMELRRNGRQCGMSEKEEE
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp150, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: ACM2_MOUSE
Sequence: MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGGTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDDNSRQTCIKIVTKTQKGDACTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is adenylate cyclase inhibition.  Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity).
What are the official names of this protein?
Muscarinic acetylcholine receptor M2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi- pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization.