PharMolix/UniProtQA huggingface dataset:
Protein: DER_SALG2
Sequence: MVPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEVEGREFICIDTGGIDGTEDGVETRMAEQSLLAIEEADVVLFMVDARAGLMPADEAIAKHLRSREKPTFLVANKTDGLDPDQAVVDFYSLGLGEIYPIAASHGRGVLSLLEHVLLPWMDDVAPQEEVDEDAEYWAQFEVEQNGEEAPEDDFDPQSLPIKLAIVGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDEREYVLIDTAGVRKRGKITDAVEKFSVIKTLQAIEDANVVLLVIDAREGISDQDLSLLGFILNSGRSLVIVVNKWDGLSQEVKEQVKETLDFRLGFIDFARVHFISALHGSDVGNLFESVREAYDSSTRRVSTAMLTRIMTMAVEDHQPPLVRGRRVKLKYAHAGGYNPPIVVIHGNQVKDLPDSYKRYLMNYFRKSLEVMGTPIRIQFKEGENPYANKRNTLTPTQMRKRKRLMKHIKKSK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RFCS_METBF
Sequence: MEDSTIKEEIWIEKYRPVRLDQVAGQEETIERLKSYVATKNLPHLLFSGPPGVGKTASAVSIAREIFGEDLWRENFTELNASDERGIDVVRTKIKNFAKTAPMGGAEFKIIFLDEADALTSDAQSALRRTMERFSNNCRFILSCNYSSRIIEPIQSRCAVFRFRRLSDEAIRKRLEYIAKDQVLSITEDGYEALVYVSQGDMRKAVNSLQAAAFVEPNKSISRGTIYRTTATANPEDIRNLIETALRGNFRVARKELNRLLYEEGLSGEDIVGQIYRAISEMDNRMILDLGLSEKRIVELVDIIGEIDFRLTEGATEKIQLEALLAHFALSNPD
What is the function of this protein?
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
What are the official names of this protein?
Replication factor C small subunit, RFC small subunit, Clamp loader small subunit.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. RfcS subfamily.
Protein: EFG_COXBN
Sequence: MATAREIPLDRTRNIGIMAHIDAGKTTTTERVLYYTGVSHKMGEVHEGSAVMDWMEQEQERGITITSAATTCYWLGMDQQYPKHRINIIDTPGHVDFTIEVERSLRVLDGAVAVFCSVGGVEPQSETVWRQANRYHVPRLGFVNKMDRAGANFLRVVNQVKDRLNANPIPIQLPIGAEEDFKGVIDLIREKAIYWNEADRGRTYELADIPEDMKVEVQKWREKMIEAAAESSEELMDKYLEAGDLSPEQIRQGLRQRTLANEIVPILCGSAFKNKGVQALLDAVIDYLPSPTDVPAIRGEEDDGSEGSRSASDDEPFAALAFKIASDPFVGTLTFFRVYSGILKSGDSVYNPIKGKKERIGRLLQMHSNSREEIKEVRAGDIAAAVGLKTVTTGDTICNQQNIITLEKMDFPEPVISVAIEPKTKADQEKMGVALGKLAQEDPSFRVHTDEESAQTIIEGMGELHLEIIVDRMRREFNVEANVGKPRVAYRETIRRSVEQQGKYIRQTGGRGQYGDVWLRIEPREPGAGFEFENAIVGGVVPREYIPAVEKGVREQMENGIRAGYPVVDVKVTIFEGSYHDVDSSEMAFKIAGSMAFKEGASKADPVLLEPIMKVEVVTPEEYMGDVVGDLNRRRGMIQGMDESPAGKIVDVEVPLAEMFGYATDLRSLSQGRATYTMEFLKYAEAPSNIAEAIIKQQS
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_ECOLC
Sequence: MRTQWPSPAKLNLFLYITGQRADGYHTLQTLFQFLDYGDTISIELRDDGDIRLLTPVEGVEHEDNLIVRAARLLMKTAADSGRLPTGSGADISIDKRLPMGGGLGGGSSNAATVLVALNHLWQCGLSMDELAEMGLTLGADVPVFVRGHAAFAEGVGEILTPVDPPEKWYLVAHPGVSIPTPVIFKDPELPRNTPKRSIETLLKCEFSNDCEVIARKRFREVDAVLSWLLEYAPSRLTGTGACVFAEFDTESEARQVLEQAPEWLNGFVAKGVNLSPLHRAML
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: CLPP_SYNC1
Sequence: MSLIPMVVEQTGRGERAYDIFSRLLKDRIIFLGGAVDDQVANLIIAQMLFLESEDPEKEIFLYINSPGGVVTAGMAIYDTMQYVRCPVSTLCVGQAASMGAVLLAAGGEGKRFALPHARIMIHQPWGGFQGQATDINIHAQEILRLRETLNGVLASHTGQTLEKIATDTERDFFMGSEEAKKYGIVDDIVKRKV
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_OLEA2
Sequence: MLGSIVKKVFGSKNDRYLKSLNHYLKEINALEENIATMPDEAISARMAELRAEVQQGTSLDSILPEVFAMVREAGKRVLGMRHYDVQMVGGIALHSGKIAEMRTGEGKTLVATLPAALNALTGKGVHLITVNDYLARRDAEWMGKIYNFLGLSVGVIVHGLNDEERRAAYASDITYGTNNEFGFDYLRDNMKFYKEQLVQRPHHFAIVDEVDSILIDEARTPLIISGPSDESTGLYRRVNDIIPRLKRDTHYTVDEKARAAALTDEGVQEAEKLLGLDNLYDPQNISFQHHILQALKAHSIFTRDVDYIVKDDQVVIVDEFTGRLMPGRRFSDGLHQALEAKEGVKVEAENQTLASITFQNYFRMYEKLSGMTGTADTEAVEFQQIYDLEVVNIPTNKPMIRKDQPDSIYRTRPEKFNAIVEEIARLHHKGQPVLVGTISIETSELIAGMLKKKGVPHNVLNAKQHEKEAEIVAEAGQAGKVTIATNMAGRGTDIVLGEGVPQLGGLYILGTERHESRRIDNQLRGRSGRQGDPGETRFFLSLEDDLLRLFGSDRIAGLMERLGMQEGEPIENKMVSRAIENAQKRVEGHNFEIRKTLLDYDNVMNQQREVIYSLRRDTMMEDDLEPSVHEFLDDIIEDIYAPLEQTKGKALDEETHAAIAARLEETFFLSRVYPEFALKGSEQQEKLPELPSAADVKKAVESMLEKLKRDAGPVYGDILRYFLLEELDRNWKEHLLNMDHLRDGIGLRGYGQRDPKQEYKREGFSLFQNMLWSIKESVFRALTRLRLQRVEEAADPAEQPEAAGLQEAKATELRHKEQPAELSYSGGDEDGAKTPSRRNAPKVGRNDPCPCGSGKKYKKCCGA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: KDSA_METCA
Sequence: MSNVETSARPFELCGFPVGLEHPLFLIAGPCVIETEQLALDTAGALKEITDGLGIPFIYKSSFDKANRSSHASYRGPGMEEGLRILAEVKRQIGVPVLTDVHEDTPLQEVASVVDVLQTPAFLCRQTNFIQNVANTGKPVNLKKGQFLAPWDMKHVAAKALATGNRHIMVCERGVSFGYNNLVSDMRSLSIMRETGCPVVYDATHSVQLPGGQGTASGGQREFVPALARAAVAVGISGLFMETHPDPDRALSDGPNSWPLDRMKALLELLSTLDRTVKASPLL
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMM_SYNJB
Sequence: MMARDPDWLLVGQVVAAHGLRGWLRVRCWSDFPERFTEPGPRWLQRDTDPEPLLHPLIEGQFFPAKGLYLVRLEGIPNRTVAETWVGARLLVPASHRLPLQPEEYHYRDLIGLAVYHQGELLGQVSGILAAGQDVLEITTSDHRQVLIPFVKALVPVVDLEKGALHVQPPPGLVESFLG
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_OCEIH
Sequence: MDILQDLESRGLIHQTTDRERLEKHLQNNQVTLYCGFDPTADSLHIGHLVPLTMLKRFQQAGHKPIALVGGGTGMIGDPSGRSSERSLNAPEVVHGFTSKLQQQIAKLVDMESNASENTVVARNNHDWLGNMTIIDFLRDAGKHFGINYMLAKESVSARIEQGITFTEFSYMILQSLDYLKLYEEENCTLQIGGSDQWGNITAGMELIRRSRENLDENIEVFGLTVPLITKADGTKFGKTAGNAIWLDASKTSPYEFYQFWFNTDDRDVIRFIRYFTFLSVEEITELEKEVETQPEKRVAQKRLAEEMTKTVHDEAALEQAKRITNALFSGDIKQLNVEEVEQAFKDVPNHIITREPVGLIDLLVDAKISSSKRQAREDVKNGAIYINGERVQDMNYHVEEKDHLGNKFTVVRRGKKKYFLIQVESIS
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_LIGS1
Sequence: MANVDMQTFDKIIVLDFGSQYNQLITRRIREFGVYSELLSHKLTAAQIKEMNPKGIIFSGGPNSVYDDGAFQIDPEIFELGIPILGICYGMQLMAHNLSGGKVESADNKEYGKAIITVKNQENVMFKDLPETQTVWMSHGDLVTQVPEGFEVTATSDNCPISAMANDAKKFYGLQFHTEVRNTEYGNDILRHFAFDVCQARSNWSMDDFIDMQIQKIRETVGDKKVLLGLSGGVDSSVVGVLLHKAIGNQLTSIFVDHGLLRKGEAEQVMDSLGGKFGLNIIKVDAKERFLNKLAGVSDPEKKRKIIGNEFIRVFDDESAKLEGIEFLAQGTLYTDIIESGTDTAQTIKSHHNVGGLPEDVQFKLIEPLNTLFKDEVRELGEKLGMPHELVWRQPFPGPGLGIRVIGEITEEKLEIVRDSDLILREEIAKHGLDKEIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVTSIDGMTADFAQIPWDVLQEISVRIVNEVDHVNRVVYDITSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: JANA_DROSI
Sequence: MNRFQLLSKGLRLIHKMSEEALAGVPLVHISPEGIFKYVMINVIDGGDASKAVIRGFADCTWHADIFEREEEVFKKLGLRAECPGGGRIEHNPDKKYLKVYGYSQGFGKADHAQTKRILATKYPDYTIEISDEGY
What is the function of this protein?
JanA and janB regulate somatic sex differentiation.
What are the official names of this protein?
Sex-regulated protein janus-A.
What is the protein family that this protein belongs to?
Belongs to the janus family.
Protein: ADAM9_MOUSE
Sequence: MGPRALSPLASLRLRWLLACGLLGPVLEAGRPDLEQTVHLSSYEIITPWRLTRERREALGPSSQQISYVIQAQGKQHIIHLERNTDLLPNDFVVYTYDKEGSLLSDHPNVQSHCHYRGYVEGVQNSAVAVSACFGLRGLLHLENASFGIEPLHNSSHFEHIFYPMDGIHQEPLRCGVSNRDTEKEGTQGDEEEHPSVTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMIRLANYLDSMYIMLNIRIVLVGLEIWTDRNPINIIGGAGDVLGNFVQWREKFLITRWRHDSAQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRECFCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGSCLLNIPKPDEAYSAPSCGNKLVDPGEECDCGTAKECEVDPCCEGSTCKLKSFAECAYGDCCKDCQFLPGGSMCRGKTSECDVPEYCNGSSQFCPPDVFIQNGYPCQNSKAYCYNGMCQYYDAQCQVIFGSKAKAAPRDCFIEVNSKGDRFGNCGFSGSEYKKCATGNALCGKLQCENVQDMPVFGIVPAIIQTPSRGTKCWGVDFQLGSDVPDPGMVNEGTKCDAGKICRNFQCVNASVLNYDCDIQGKCHGHGVCNSNKNCHCEDGWAPPHCDTKGYGGSVDSGPTYNAKSTALRDGLLVFFFLIVPLVAAAIFLFIKRDELRKTFRKKRSQMSDGRNQANVSRQPGDPSISRPPGGPNVSRPPGGPGVSRPPGGPGVSRPPGGPGVSRPPPGHGNRFPVPTYAAKQPAQFPSRPPPPQPKISSQGNLIPARPAPAPPLYSSLT
What is the function of this protein?
Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5 (PubMed:19273593).  May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins (PubMed:10825303).
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 9, ADAM 9, Meltrin-gamma, Metalloprotease/disintegrin/cysteine-rich protein 9, Myeloma cell metalloproteinase.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HOX7P_XENLA
Sequence: GSLQLLLLLLLLQCDKKGICSCAPLLTAMSSPRRIKEDLSSDEEGQVHPTLSPSEDHKIKISSLPFSVEALMADKRVPKEAPPSRAVDSSAATSTPNRHLHLGIRDSPSPLGSQKGLKPRRSNRKNSEDGTSWSKDGGSYSPPPRHLSPSSCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAEIEKLKMAAKPILPPGFSIPFPINSPIQAASLYGSSYQFHRPVLPIPPMGLYATPVGYSMYHLSEEGDMT
What are the official names of this protein?
Homeobox protein XHOX-7.1'.
What is the protein family that this protein belongs to?
Belongs to the Msh homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PI15_CHICK
Sequence: MTIIAAISCVFLFSILCETSALVLPNSTDLLLSNNNFTDIETALAAHLDSAKIPKARRKRYISQNDMIAILDYHNQVRGKVFPPASNMEYMVWDETLAKSAEAWAATCIWDHGPSYLLRFLGQNLSVRTGRYRSILQLVKPWYDEVKDYAFPYPQDCNPRCPMRCYGPMCTHYTQMVWATSNRIGCAIHTCQNMNVWGSVWRRAVYLVCNYAPKGNWIGEAPYKVGVPCSACPPSYGGSCTDNLCFPGVTSNYLYWFK
What is the function of this protein?
Serine protease inhibitor which displays weak inhibitory activity against trypsin (By similarity).  May play a role in facial patterning during embryonic development (PubMed:26385749).
What are the official names of this protein?
Peptidase inhibitor 15, SugarCrisp.
What is the protein family that this protein belongs to?
Belongs to the CRISP family.
What are the subcellular locations of this protein?
Secreted.
Protein: IPYR_CHLMU
Sequence: MSKTPLSIVHPWHGPVLTRDDYESLCCYIEITPSDSVKFELDKETGLLKVDRPQKFSNFCPCLYGLLPKTYCGDLSGEYSGQQSNRDNIKGDGDPLDICVLTEKNITQGNILLQARPIGGIRILDSGEADDKIIAVLEDDLVYGAMEDISDCPGSVLDMIQHYFLTYKATPESLIQAKPAKIEIIGLYGKKEAQKVIRLAHEDYCNLFM
What is the function of this protein?
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
What are the official names of this protein?
Inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSE6_PSEAE
Sequence: MDAQAAARLGDEIAHGFGVAAMVAGAVAGALIGAAVVAATAATGGLAAVILAGSIAAGGLSMFQIVKGLTTIFELPEPTTGVLIRGSFNVYVNSRNAMRAGDDVSATCSGLPLNHPLWPFPVLIAEGSATVYINGKPAARLQSKMVCGAHIKTGSQNTFIGGPTERVAFVLDLEEWLHTGLEALGLAALAGGLLLAAMAGVAALVGVVAIGGLMMGGMALLGDLGDRLGPGYRDLFQGVAGMALLGFGPKLAGRRPAAVTSETAQRRAYLNNKFGRSGNLDHDINYRGNRETAAKFFKSKDIDPADAESYMNGLDFNHPVRVETLAPGKNLWQYQSPGAPQGNWYTLSPRVQPTELGINPMGTNRAANTIEPKVLNSYRTTQKVEVLRSTAAPTDDFWSVKGQSYPAKGGAQQLFSNEKGSFGLLPREGS
What is the function of this protein?
Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis.  The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6.
What are the official names of this protein?
NAD(P)(+) glycohydrolase toxin Tse6.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RUVB_ACET2
Sequence: MEDRLVGCRLSEEDVDEVSLRPRKFGEYIGQTKVKENLMVFIEAAKKRNEALDHVLLYGPPGLGKTTLAGIIASELGVNLRITSGPAIEKPGDLAAILTNLGNFDVLFIDEIHRLNRSVEEILYPAMEDYALDIIIGKGPSARSIRLDLPKFTLIGATTRAGLLTSPLRDRFGVINKLELYSVEELGQIVKRSARILNVGIEDEAAEEIARRARGTPRVANRILKRIRDFAQVKSDGFITKEIARTGLEALEVDEIGLDAVDRNLLMSIIEKFGGGPVGLDTLAATIGEEPDTIEDVYEPYLLQLGFINKTPRGRMATKLAYEHFGLKYE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MEFV_RAT
Sequence: MANTRVDHLLNTLEELLPYELEKFKFKLHTTSLEKGHSRIPLSLVKMARPIKLTRLLLTYYGEEYAVRLTLQILRATNQRQLAEELHKATGPEHLTEENGVGGSVQSSAENKDKGVKGSDVPGEDEAQQNDDESDILPPIQAEVGKGPQKKSLAKRKDQRGPESLDSQTKPGARSAAPLYRRTLVTQSPGDKENRAGAQPQECQLCREAARSTAMSQGGERSRRLKCICLQERSDPGVLKLPLTQKKENPQIQKLFRLKRKQEMAVSFVREATLNGRTTGTLEKGVGIPEHSMMLDEETSRNMSSKISLTREKRCTASWTENGNGGPETPETLGETVSSILCDSCSPKVLLSLGEKLAQTPEDPASLGQAASKGRSRDKVACPLCHTQGELPAKACVQSSCSCSVAPGDPKASGRHSICFQCQSSRAGKSCEAQSPQFLPQCPRHMKQVQLLFCEDHREPICLICRLSQEHQGHRVRPIEEAALQYKEQIRKQLERLREMRGYVEEHKLPADKKAEDFLKQTETQKQRISCPLEKLFQFLEQQEQLFVTWLQELVQTIGKVRETYYTQVSLLDKLIGELEAKQDQPEWELMQDIGATLHRAETMTASELLGIPPGVKEKLHLLYQKSKSAEKNMQRFSEMLGSEMAFSASDVATREGCRPSTTKAQALIPTVHLKCDGAHTQDFDVILCAELEAGGSEPQDYLHPSSAQDTPELHEIHSQNNKRKFKSFLKWKPSFSRTDRCLRTCW
What is the function of this protein?
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma.  Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy.  Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation.  However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity).  Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (By similarity).  It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation.  Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity).
What are the official names of this protein?
Pyrin.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection, lamellipodium. Cytoplasm. Cytoplasmic vesicle, autophagosome. Nucleus. Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (By similarity).
Protein: E4PD_VIBC3
Sequence: MLRVAINGFGRIGRNVLRAVYESGKRDRIQVVAVNELAKPDAMAHLLQYDTSHGRFGKKISHDQQHIYVHHQNGEYDSIRILHLSEIPLLPWRDLGVDLVLDCTGVYGCQEDGQQHIDAGAKLVLFSHPGASDLDNTIIYGVNHETLTAEHKIVSNGSCTTNCIVPIIKVLDDAFGIDSGTITTIHSSMNDQQVIDAYHNDLRRTRAASQSIIPVDTKLHKGIERIFPKFSNKFEAISVRVPTVNVTAMDLSVTIKSNVKVNDVNQTIVNASQCTLRGIVDYTEAPLVSIDFNHDPHSAIVDGTQTRVSNGQLVKMLVWCDNEWGFANRMLDTALAMQATQ
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS8_MYCBT
Sequence: MTRSGHPVTLDDLPLRADLRGKAPYGAPQLAVPVRLNTNENPHPPTRALVDDVVRSVREAAIDLHRYPDRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYSMHPIISDGTHTEWIEASRANDFGLDVDVAVAAVVDRKPDVVFIASPNNPSGQSVSLPDLCKLLDVAPGIAIVDEAYGEFSSQPSAVSLVEEYPSKLVVTRTMSKAFAFAGGRLGYLIATPAVIDAMLLVRLPYHLSSVTQAAARAALRHSDDTLSSVAALIAERERVTTSLNDMGFRVIPSDANFVLFGEFADAPAAWRRYLEAGILIRDVGIPGYLRATTGLAEENDAFLRASARIATDLVPVTRSPVGAP
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: SYN_BORBU
Sequence: MFASIKDILKNPILNSNVTINGWIRTKRSNGKIGFIEINDGSTLKGIQAVINEEENQFSEKDLKKLTTGTSISLTGLLVESPAKGQNYEIKTHSFNVIGETDPETYPLQKKRHSFEFLREIPHLRIRTNTFGAIARVRNKISYKIHEYFQKNGFFYINTPIITSNDGEGAGEMFRVSTLKFNKLNNALSNIDFKDDFFGKEAFLSVTGQLHGEAYAMALSKIYTFGPTFRAENSNTTRHASEFWMIEPEMAFYKLNDNIALAEDLLKYLLSSILNECSQDMDFLENYIEKGLIKKLENVINSNFEVITYTKAIEILENSKKNFEIKPYWGIDLQTDHERYLTEETFKKPVVVIDYPKNFKAFYMKANKDNKTVKGMDILVPKIGEIIGGSEREDDLQKLENRIKELNLNIEHLNWYLDLRRFGSAPHSGFGLGLERLVQYSTGISNIRDSIPFPRTPKNLYF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_PSESM
Sequence: MSKSLQAIRGMNDILPEQTPLWRHFEGTVSRLLDNYGYRQIRMPVVEFTDLFKRSIGEVTDIVEKEMYTFADRNGDSLTLRPEGTAACVRAVLEHGITGGGQVQKLWYIGPMFRHERPQKGRYRQFHQIGVEVFNLDGPDIDAELIVMTWRLWGMLGIRNAVKLELNSLGTSEARARYRDALVEFLSAHLDQLDEDSQRRLKTNPLRVLDTKHPETQAVLVDAPKLADYLDDESRIHFEGLKARLDAAGIPYVINPKLVRGLDYYSKTVFEWVTDQLGAQGTVCAGGRYDGLVEQMGGKPTAGVGFAMGIERLVLLLETLEQVPEEIARQVDVYLCAFGEAAELAALALTEQVRDRLPNLRLQVNAGAGSFKSQFKKADKSGALYALILGEEELAAKIIGVKPLRGQGEQQNIAWDALSEHLASCVVQG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AURE_AURAU
Sequence: MGCFKVLVLFAAILCMSLLVCAEDEVNLQAQIEEGPMEAIRSRRAACSDRAHGHICESFKSFCKDSGRNGVKLRANCKKTCGLC
What is the function of this protein?
Antimicrobial peptide with modest activity (PubMed:16890198, PubMed:23137541).  Active against the Gram-positive bacterium L. monocytogenes (MIC=22. 64 ug/ml), B. megaterium (MIC=10 uM), B. mycoides, B. subtilis, M. luteus (MIC=40 uM), M. phlei, and S. aureus, and the Gram-negative bacterium E. coli (MIC=7. 66 ug/ml) and P. aeruginosa (PubMed:16890198, PubMed:23137541).  Shows moderate affinity to the negatively charged (POPC/DOPG 3:1) lipid vesicles (PubMed:23137541).  The peptide interacts with the surface of DPC micelles by two alpha-helical regions (PubMed:23137541).  It does not interact with the zwitterionic (POPC) lipid vesicles, which model membranes of eukaryotic cells (PubMed:23137541).
What are the official names of this protein?
Antimicrobial peptide aurelin.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 1 potassium channel toxin family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Isolated from mesoglea.
Protein: MAMV_MAGSA
Sequence: MLGRPMKPSKCQECRDRAAWLDMFTALALAVFKTALGVLSGSMALQAHSLHSFGDFLTKGINLASVKLSSRPANSAFPYGYGKVQFLSANFIGISLMAGAAAMLWYNVTHLGSGHVQVPEVWAVFGALISAGTAELMHRYLRCVAEHTNSPAIMAAAADNRGDAYSSLAVLAGIVLSILGWVAADHLAAILVSLLVLRIGAVIAWDSIHGLMDGSVPSHRIDGIRQLLAAHHPGVSVVDLRGRRMGETWEVDLQLSISSQVTVEECHALTRELESRIAREEPHACHIRIRFIPQSGDATKTAVIETAAAVDEFAYLVEASAALRPLGHSRNGG
What is the function of this protein?
Expression of just the minimal mamAB gene cluster (amb0961 to amb0978), including this gene, is sufficient to form a minimal magnetosome chain with small magnetite particles.
What are the official names of this protein?
Putative transporter MamV.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.