PharMolix/UniProtQA huggingface dataset:
Protein: BIOD_YERPG
Sequence: MTKRWFITGTDTDVGKTVASCALLQAATAQGYRTAGYKPVASGSQMTADGLRNSDALALQANSSQRLGYSQVNPFTFLEATSPHIASESEGRAIPLTALSQGLRQLEPSADWILIEGAGGWFTPLSPQATFADWVQQEQLPVIMVVGVKLGCINHALLTAQAIQHAGLTLAGWVANEVTPAGRRQAEYQATLTRMITAPLLGIIPYLSDIEENPVTTRRDLGHYLDLTVLRAAEREAVNM
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBA_VIBCH
Sequence: MAEVRARVDFKVGAKSNIDAEILSFHGLQSDKEHVAVIFKSADTTQEAPLVRMHSECLTGDVFHSSRCDCGEQLEETITRMGQSGGIILYLRQEGRGIGLYNKIDAYRLQSQGMNTYEANNHLGFGDDLRDFTEAAQMLQALGVKKIRLVTNNPKKIRELQEHGIEIVEVVHTSAHIKDGNENYLKAKVSHGKHQLKL
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: KAPS_EMENI
Sequence: MATNITHHAGITRNERNQLRKQKGLTIWLTGLSASGKSTIAVELEHQLLQRGLHAYRLDGDNVRFGLNKDLGFSDADRNENIRRIAEVAKLFADSSSIAITSFISPFRADRDTARKLHEVPTPNDSTGLPFVEVFVDVPIEVAEKRDPKGLYKKAREGIIKEFTGISSPYEAPENPEVHVKNVDLPIQEAVKQIIDYLDSKKLLDA
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase, APS kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: UDDP_SULAC
Sequence: MRKYYYWILLLLFLILSIYIKLIGGEQNIGFNVELFKLINYNQIATLNGLMVFLSKYGREYVWIPVTALLLIFKRTRKIGITLVISFVIAIVLGEVSKYVMAQLRPFNFVNPTYLLEPKPTDYSYPSGHALIVSTGAVTLLLTSPKWMWILGIIEAVLVSYSRVYVGVHWPLDVIAGWLLGSWISFLSVQIESTGPIKKIEQMLKA
What are the official names of this protein?
Undecaprenyl-diphosphatase, Dolicholpyrophosphatase.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CNR1A_TAKRU
Sequence: MKSVLDGVADTTFRTITSGLQYLGSNDANYDDPLNDAAFKTGFSLQKPLSAFRSNSFPNKVPADEELIFKGIPFFPTNSTDLFGNRNTTRDENSIQCGENFMDMECFMILTPSQQLAVAVLSLTLGTFTVLENLVVLCVIFQSRTLRCRPSYHFIGSLAVADLLGSVIFVYSFLDFHVFHKKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYRRIVTRTKAVIAFCMMWTISIIIAVLPLLGWNCKRLNSVCSDIFPLIDENYLMFWIGVTSVLVLFIIYAYIYILWKAHHHAVRMLSRTSQKSLVVYSAEGTKVQTTRPEQTRMDIRLAKTLVLILAVLVICWGPLLAIMVYDLFWKMDDNIKTVFAFCSMLCLLNSTVNPIIYALRSRDLRHAFLSSCHACRGSAQQLDNSLESDCQNRNVNISANRAAESCVKTTVKIAKVTMSVSTETSAEAV
What is the function of this protein?
G-protein coupled receptor for cannabinoids (By similarity).  Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues (By similarity).  Regulates cellular respiration and energy production in response to cannabinoids (By similarity).  Signaling typically involves reduction in cyclic AMP (By similarity).
What are the official names of this protein?
Cannabinoid receptor type 1A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane. Cell projection, axon. Presynapse. Note=Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic.
Protein: MED20_DANRE
Sequence: MGVTCVCQVPVAEGKSVQQTVDLLHRKLEQLGAVKQGNFWVDCETYHATGNATGQPSKLLYVMHNSEAPLSCMALFEGGPGLSADANFDVLMIKLKSHFQNAKGHKVESRGTRYRYCDFLVKIGTVAMSSSARGISVEVEYCACVIPGDCWNLMKEFMQSFLGSNTPELPTVFTNKAEGLYVPVDCMDTMSQYLELFSKVRKQQVLPGSGVR
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 20, Mediator complex subunit 20, TRF-proximal protein homolog.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 20 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PHUZ_BPPA3
Sequence: MSKVKTRVYCCGGTGMDIGVNLQWHPDLVFIDTCDKNVTADHDLERVFLTEGTRGAGKNRRYMLPIIRPQVPGFLERYPAGDFNIVVFGLGGGSGSTIGPVIVSELAKAGESVAVVCMSGIEATEVLQNDIDTLKTLEGIAAATNTPVVINHIENVNGVPYTELDKEAIFNIHALINLTSQKHVRLDKLDIDNWINFTKKHNQIQPQLCQLHISNNRQEATSVPEPIAIASLFADASREVAFGTPFVRTVGISDVSDPDLLADQLHFVINSIGVASLFGSLTKQKQELEAAQVRYQQRNAIIDIDDNRTDDGFVV
What is the function of this protein?
A tubulin-like GTPase that forms filaments, which are required for positioning viral DNA and capsids in the middle of the host cell for optimal replication (PubMed:31199917).  The motor component of a partition system which pushes phage DNA (encased by protein gp105) to the center of the bacterial host cell (By similarity).  Also required for movement of phage capsids to the vicinity of the DNA and rotation of the encased viral DNA at midcell (By similarity).  Forms filaments during the lytic phase, which position phage DNA at the center of the bacterial host cell (PubMed:31199917).  Filaments have a three-stranded intertwined architecture and form a spindle-like cytoskeleton within the infected cell (By similarity).  Has GTPase activity (By similarity).  Filaments grow at the plus end and depolymerize at the minus end, a process called treadmilling, and switch from growing in a polar manner to catastrophic depolymerization, i. e.  they display dynamic instability, like tubulin (By similarity).  In infected host cells the filament ends close to the cell pole are relatively stable, while the other end near the phage DNA is highly dynamic (By similarity).  Both capsid movement and DNA rotation probably require treadmilling (Probable).
What are the official names of this protein?
Phage tubulin-like protein, PhuZ, Phage tubulin/FtsZ, Tubulin-like protein TubZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family. PhuZ subfamily.
What are the subcellular locations of this protein?
Host cytoplasm. Note=In infected host cells forms a spindle-like structure emanating from each cell pole.
Protein: UBP6_HUMAN
Sequence: MDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKKLTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSPQENRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSWLARPLPPQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCAWCPQYRFCRGCKIDCGEDRAFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFLVPRDPALCQHKPLTPQGDELSKPRILAREVKKVDAQSSAGKEDMLLSKSPSSLSANISSSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVTPQDHEVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQGIDYAQFLPKIDGKKMADTSSTDEDSESDYEKYSMLQ
What is the function of this protein?
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety.  Catalyzes its own deubiquitination.  In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity.  Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking.  Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 6, Deubiquitinating enzyme 6, Proto-oncogene TRE-2, Ubiquitin thioesterase 6, Ubiquitin-specific-processing protease 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
Protein: NUOB_METC4
Sequence: MALTPTFSRAPDIAPAPKGIIDPATGRPIGANDPTFLSINDELADRGFLVTSADELINWARTGSLMWMTFGLACCAVEMMQMSMPRYDCERFGFAPRGSPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVISMGSCANGGGYYHYSYSVVRGCDRVVPVDIYVPGCPPSAEALLYGVLLLQRKIRRIGTIER
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1501_ARCFU
Sequence: MMIPKGEVVELGKRGNFRDILKELSATGFTGYLEVSYKKGELSRAKVLFSNGKIVAAGIKRVISKSEIVGEKALEELLGLESCVVDVYALDEGKVAKALEWNRNAVVEHLPETEVEVEGGLTEEIITTPDEREAILKKYGIKMPSEEEIDQIIMNALDGSYDVIAATTSAPGDFESLKNSLISTAELYLGKMSKKVVDVINDCKSAEELVERFDEIRSAAKSLVIFIPRKKIDEMLSEMERLIGESI
What are the official names of this protein?
Uncharacterized protein AF_1501.
Protein: TFB5_KLULA
Sequence: MTRARKGTLVQCDPSIRALILRMDADRNDIIYEELDDTHLLVDPSKVEFIKYELNRLLSENIYNPLDEEENA
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit TFB5, TFIIH subunit TFB5, RNA polymerase II transcription factor B subunit 5.
What is the protein family that this protein belongs to?
Belongs to the TFB5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NP_ADEM1
Sequence: MSILISPSDNTGWGLGTGKMYGGARKRSAEHPVHVRSYWRAAWGSRNRRRVATVAAEDAEAPQLEDVAQAPATVPIVRRHRRRVGGSARTRGLRKSARVRAAARAIVRAVNGAAAAAAPTVPASANFAAMVGAIANARAAYRHRRSRAGINPVPASRSTTRVRLPRTVRFHPSMGAFHRRWWRIHTRGRRKASVRRRRT
What is the function of this protein?
Plays a role in the inhibition of host immune response within the nucleus.  Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin.  In turn, prevents HMGB1 release out of the cell and thus decreases inflammation.  Also plays a role in the wrapping and condensation of the viral DNA.  May also promote viral genome import into the nucleus.
What are the official names of this protein?
Pre-histone-like nucleoprotein, Pre-core protein VII, pVII.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae histone-like nucleoprotein family.
What are the subcellular locations of this protein?
[Histone-like nucleoprotein]: Virion. Note=Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion. SUBCELLULAR LOCATION: [Pre-histone-like nucleoprotein]: Host nucleus, host nucleolus.
Protein: UCDH_STRR6
Sequence: MIKKVTIEKIKSPERFLEVPLLTKEEVGQAIDKVIRQLELNLDYFKEDFPTPATFDNVYPIMDNTEWTNGFWTGELWLAYEYSQQDAFKNIAHKNVLSFLDRVNKRVELDHHDLGFLYTPSCMAEYKINGDGEAREATLKAADKLIERYQEKGGFIQAWGDLGKKEHYRLIIDCLLNIQLLFFAYQETGDQKYYDIAESHFYASANNVIRDDASSFHTFYFDPETGQPFKGVTRQGYSDDSCWARGQSWGVYGIPLTYRHLKDESCFDLFKGVTNYFLNRLPKDHVSYWDLIFNDGSDQSRDSSATAIAVCGIHEMLKHLPEVDADKDIYKHAMHAMLRSLIEHYANDQFTPGGTSLLHGVYSWHSGKGVDEGNIWGDYYYLEALIRFYKDWNLYW
What is the function of this protein?
Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides.  Also degrades unsaturated heparin disaccharides.  Releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds.  Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans.  Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such as chondroitin and hyaluronan.
What are the official names of this protein?
Unsaturated chondroitin disaccharide hydrolase, Unsaturated glucuronyl hydrolase, SpnUGL.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 88 family.
Protein: RIR2_BUCBP
Sequence: MTYTTFSKNKNNQLYEPMFFGQSVNISRYDQQKYEIFEKLIEKQLSFFWRPEEVDLSRDYIDFQNLPQHEKHIFVSNLKYQTLLDSIQGRSPNIALLPIVSLPELETWIETWSFSETIHSRSYTHIIRNIINTPSLIFDDIIDNKNIANRAKDIAKYYDDLIELTSYWHLFGEGKHTINGKKIKIDLHELKKKLYLCLISVNALEAIRFYVSFACSFAFAEREKMEGNAKIIRLIARDEALHLTSTQHILNILHNDKNNEGMSDISKECYEECYHLFIRVSDQEKIWAKYLFQNGSMLGLNQEILSQYIEYITNIRMKAIGLPSPFKILSNPIPWINSWLISDNVQVAPQEISVSSYLIGQINSEINDSDFEKFKL
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
What are the official names of this protein?
Ribonucleoside-diphosphate reductase subunit beta, Ribonucleotide reductase small subunit.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase small chain family.
Protein: WDR24_DROME
Sequence: MPDSVEDTSTISLRICLEGHANALALNKDNNQIALAGRSLLKVYSINSNGFTESCNMRGKNQNLSYSANDVAWSTLDSNLLATAATNGVVSVWDLSKFGRQKQLLVYNEHERTAHTVTFHSSEPNILISGSQDGTIKCFDIRSDKSINTYFCNSESVRDVKFSPHTQNIFSAVSENGTVQLWDMRKWDKCMVQFTAHYGPVYTCDWHPTRNWLATGSRDKQIKVWNMDGRPGLEHTIHTIAVVGRVKWRPERTYHIASCALVVDYSVHVWDIRRPYIPFASFNEHTNVTTGIAWQGSDSHCLLSISKDSTIYKHAFKDATRPALKANAQGASLGRFGDISFANKIKEYEPKTSGASNTKSSSFIRRKTNVAGSIQFHLDHSKMYKFMVNDTFSGYPLSESVSRPTQEHESFIGCARELVISGKKLSELCEHNAEVSKKYGKHNATTLWNFIKLFYGSNHFEPPFEHRSSFSNQKNPMNSRRATQVASDWPQQRTELGQDLNGNTPETAHEIDVANVDDDTLGSSGVEHPPTSSVILSETQIISEITFDNFELLRNGFIYVGPTECPKALAFPALHHDVQAARPQLDLKASDHEKSPPPHVPTVLKVSHVPPIPMWEPHKFVSDALMLMNDVGDVQTALTVLIALGEARKLLPIDDALVEHWFYTYVDQLHRYELWNEACEVINRSWLRSVQQLNQHSTAMHTNCGECGRPMGGKVGWYCDKCKSMQSAKCCVCGLIVRGVYAWCQGCSHGGHIEHLQKYFAKHSKCPKCGHLCAYS
What is the function of this protein?
An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:27166823, PubMed:23723238).  The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823, PubMed:23723238).  GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:27166823, PubMed:23723238).  This GATOR2 component is required for activating TORC1 and promoting cell growth in both germline and somatic cells (PubMed:27166823, PubMed:23723238).  In addition to its role in regulation of the TORC1 complex, functions independently of TORC1 to promote the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
What are the official names of this protein?
GATOR complex protein WDR24, WD repeat-containing protein 24.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR24 family.
What are the subcellular locations of this protein?
Lysosome. Cytoplasmic vesicle, autophagosome. Note=Localizes to lysosomes and autolysosomes under fed and starved conditions (PubMed:27166823). In female egg chambers, localizes primarily to autophagosomes and autolysosomes during amino-acid starvation (PubMed:27166823).
Protein: MNME_YERPB
Sequence: MSTTDTIVAQATPPGRGGVGILRVSGRAASEVAHAVLGKLPKPRYADYLPFKDVDGSTLDQGIALYFPGPNSFTGEDVLELQGHGGPVILDLLLKRILALPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSAVNSLQGAFSARIHQLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEGQLNGVMADLEQVRTEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREANDEVERIGIERAWNEIEQADRVLFMVDGTTTDATEPAAIWPEFMARLPATLPITVVRNKADITGETLGLTKVNGHSLIRLSARTGEGIDLLRDHLKQSMGFTSNTEGGFLARRRHLQALETAARHLVQGHEQLVSAYAGELLAEELRLAQQSLSEITGEFSSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAF5_CAEEL
Sequence: MSDSPIGSSQQVEPEHRTPDLMDIDPLIANLKALHEETRSDDDDDGQPSTSAKRKDSRADGIVIHQKKYSDPGRFLWIWLLGVRVPALSIDGEPHLPIEILDDMLTKKDKKDQMSFQNLLRYKNVYIRMASPSQFRAVMEKSKECENLNITSLSLMSRSDIERIMGELRLESMLTLAEHDNWDISDRVHVVHVNFIDYCSEWLESDDLEEDVMQSGTHGYWYKNRRNMRCIECQHCEGKFTPTDFIMHHHYPIKPSGFVHTGCNSFQWIRLIEVFDKSNENLEAWNKFVLNSHRAGKREYDEAAPHQAPPKRPAMETPVPVAADNGWEADEEEEGEEIVDRDADIEKCKLRNKKKMENLHIADFLGPSGSKGLKPRNKFEAVIIEQLNKMDDAALEALFLKSPEEYNLWVKESDFTHKVVTQQQEWKAKMKDPNFKSRASANFDVSKGEFDNMRHFDNASKATRQEIQQLAEQFANLDRDAKLLTPMEFVLREHALLKNVSADAIRVLCNRPPLPPLPPPPPPPKPKPAPVQPISLGNINFVALAQQLIASGIKLPLPIVTPPVVSTPAPVITPIPAALPISPNSDFLKQQLSTAMSSPALLSLYPKLTAGAYEQLAQFIKTTTVKN
What is the function of this protein?
Probable component of transcriptional regulatory complex with SMAD protein daf-3 (PubMed:14681186).  Required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions (PubMed:14681186).  Involved in larvae undergoing cell-cycle arrest during the dauer stage (PubMed:14681186).
What are the official names of this protein?
Ski protein homolog, Abnormal dauer formation protein 5.
What is the protein family that this protein belongs to?
Belongs to the SKI family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DISP3_CHICK
Sequence: MDTEDDPLLQDAWLDEEDEEVAFSSRKRREGALLCGKSSCRVRPLRVTLPVSGFWNIVGWIFTNPYCAGFILFLGCAIPAVLAVVMFLHYPALDIDISYNAFEIRNHESSQRFDALALALKSQFGSWGRNRRDLADFTSETLQRLIFEQLQQLHLNASHLQVSTRAKRSAPQGRTSSPEPRAHPHPGNETSRVTRGAPRWDYSNTYISANTQTHAHWRIELIFLARGDSENNIFTTERLVTIHEVERKIMDHPRFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIQGSLELAMTHPEFYWYVDEGLSAENKKSSLLRSEILFGAPLPNYYSVEDRWEEQRHKFQNFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAVLVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLKDLRLRMIHTIQTAGKATFFTSLTTAAAYAANIFSQIPAVHDFGLFMSLIVSCCWVAVLFTMPAALGIWTLYVSPLESSCQNSCSQKCTKKSTLHLAEDLFVASEGTSRAGRETLPYLDDDIPLLSVEEEPVSLEMGDVPLVSVMPENLQLPVEKSNRGHLIAHLQELLEHWVLWSAVKSRWVIVGLFLLVLLLSIFFASRLRPASRAPVLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNFRTSLEKKKRGSASPWGSKGSISDTGQQDLQGTVYISKSRSKGRPAIYRFSLNASIPAPWQMVSPGDGEVPSFQVYRVPFGNFTRKLTACVSTVGLLKQTSPRKWMMTTLSCDSKRGWKFDFSFYVAAKEQQRTRKLYFAQSHKPPYHGRVCVAPPGCLLSSSPDGPTKGILYVPSEKAAPKARLSATSGFNPCMNMGCGKPAVRPLVDTGAMVFVVFGIRGVNRTKNSDNHVIGDMGSVIYDDSFDLFKEIGNLCRLCKAIASNTELVKPGGAQCLPSGYSISSFLQMLHPECKNIPEPNLLPGQLSHGAVGVKDGKVQWISMAFESTTYKGKSSFQTYADYLKWETFLQQQLQLFPEGSALRHGFQTCEHWKQIFMEIIGVQSALYGLILSLVICVAAVAVFTTHILLLLPVLLSILGVVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPLHHAEDPTACRQWRTIEAIRHVGVAIVSSAVTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLSIMGPGTFTRSRTSCLKAVAGVLLAGLLGLCICLALLKGGFKIPLPNGTAL
What is the function of this protein?
Plays a role in neuronal proliferation and differentiation (By similarity).  Plays a role in the accumulation of cellular cholesterol (PubMed:19179482).  Involved in intracellular lipid droplet formation (PubMed:19179482).  May contribute to cholesterol homeostasis in neuronal cells (PubMed:19179482).
What are the official names of this protein?
Protein dispatched homolog 3, Patched domain-containing protein 2, Thyroid hormone receptor up-regulated protein 1, TRUP1.
What is the protein family that this protein belongs to?
Belongs to the patched family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Predominantly localized to cholesterol-enriched domains within membranes (PubMed:19179482). Localizes to cytoplasmic punctate vesicular structures (PubMed:19179482).
Protein: COQ4_DROER
Sequence: MMQRCLRLPKLLALRRDLHLAQVERQAVVTEAPEAEPQDAFERQYFKERIEISPFQRVFLAAGSSIAALLDPRRHDMIACLGETTGEDALWTILDSMQASEEGQRIMADKPRIHTSTIDFKYLETLPPDTFGAAYVKFLKDNQVTPDSRMAVRFLEEPKLAYLMTRYRECHDLIHTVLDMPTNMLGEVSVKWVEALNTGLPMCYGGAVFGAVRLRPKQRRAYLKHYLPWALENGKRTKPLMPVYWEKRWEQNIHDLRSELGITVLNKA
What is the function of this protein?
Component of the coenzyme Q biosynthetic pathway.  May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis.  Required for steady-state levels of other COQ polypeptides.
What are the official names of this protein?
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial, Coenzyme Q biosynthesis protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the COQ4 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: CYK7_CAEEL
Sequence: MSDNLSARWHRILDMTNRETSDDVVIARSSFDDFSQSTPWRKFEISCGNRSFFVNPGWLAELSPYFADELYVRKPNVQRYVIDQATPDEVLEFLRCITFCPMRKPLTVKNVSLVLTFANRFEMRPVQARCENFIAQNATSLSRDKTKLFQFFPLQVTCAMSQCDPNSSTMSVLVDKLAGIKDDELSRLHFAEMPGDVVAEVYAQKIQRTKDKKAQRQAGASDETAAGCCFMQWASSLFNRRRQRNQADQSILPPSGDQQHHRSELHA
What are the official names of this protein?
Cytokinesis defective protein 7.
Protein: YIIZ_SALTY
Sequence: MKQPGFIRLATLALLSTLSFFSHGETILRLAYAENSQPVKDALHFLGQQVEEKTGGDIKVQYFPDGQLGGERELVELTQVGVVDITKVSSGLMESFSPEYGVFSLPYLFATVEEYYRVMDNPQVMEPVYQSTAAQGFIGVGWYDSGARNFYMSKAPIKRIEDLRGKKIRVMQSETAIQTLKLLGASPIAMSQAEVYTSLQQGILDGAENNEFALTIARHGEVARYYTYDMHTRIPDILLMSTLTLEKLTPEQQRIVEAAIKASIEFEKAAWDKEIEKTRLAAVKDFNVEFYEIDKKPFQEAVQPIYDGLKNKPRLYGLYQRIQTAKN
What are the official names of this protein?
Uncharacterized protein YiiZ.