PharMolix/UniProtQA huggingface dataset:
Protein: FTSB_XANCB
Sequence: MRNWRWLLLVLAVLLAWLQYRFWFGPGNSGEVMMLEAQVAHQTRDNEGLRQRNQALAAEVKDLKDGEAAIEERARSELGMIKPGETFYRVVEDAPLLPPAAQEAAPPAQPPAASADPVDHP
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: RS4_STRPS
Sequence: MSRYTGPSWKQARRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFTYGVGEKQFRNLFVQATKIKGGILGFNFMLLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSYRVTPGQVISVREKSLKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: NUOD2_SOLUE
Sequence: MPDSTFLDSTELVLNMGPQHPSTHGVLRVILKLDGEKVLGTDCIIGYLHRGVEKIAENRTYAQFNPYVDRMDYVAAVSNGLGYCLAIEKLLNVEAPPRAQCIRVILTELNRIASHLLWLGTHALDIGAITPVFYCLREREEALKIFEKYCGARLTTHAFRIGGLLYETYDGFEQEIRDFCKMFIPKVDEYEELLTNNRIWVGRLKDVGILSADECKEFGVTGPVLRAAGVKWDLRKAQPYSGYEKYDFEIPTRVNGDTYDRYIVRMEEMRQSVRIMQQAVDGIPEGPIMGKVGKVIKPPIGEAYVSIEAPKGELGYYAVSDGSTQPYRIRVRPPSFVNLQALDRMIRGGLIADVVAVIGTLDIVLGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D 2, NADH dehydrogenase I subunit D 2, NDH-1 subunit D 2.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PCKA_SHIBS
Sequence: MRVNNGLTPQELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLVTRQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGGEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDALLENVTVREDGTIDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEKAETLAKLFIDNFDKYTDTPAGAALVAAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_GLUDA
Sequence: MSREAMYDIVRAPLITEKATALSEKNQVAFKVAIDATKPEIKVAVETLFGVKVLGVNTLVQKGKTKRFKGRPGQRSDVKKAFVQLAEGQSIDLTAKLV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PLSY_SALSV
Sequence: MSAIAPGMILFAYLCGSISSAILVCRIAGLPDPRESGSGNPGATNVLRIGGKGAAVAVLIFDILKGMLPVWGAYALGVTPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKLKKKRQKDSE
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PA2BA_LATLA
Sequence: MYPAHLLLLLAVCVSLLGASAIPPLPLNLAQFALVIKCADKGKRPRWHYMDYGCYCGPGGSGTPVDELDRCCKTHDECYAQAEKKGCYPKLTMYSYYCGGDGPYCNSKTECQRFVCDCDVRAADCFARYPYNNKNYNINTSKRCE
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 PC10, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AASD1_BOVIN
Sequence: MAFRCQRDSYAREFTTTVVSCRPAELHTEESNGKKEVLSGFQVVLEDTLLFPEGGGQPDDRGTINDISVLRVTRRGTQADHFTQTPLTPGTEVQVRVDWERRFDHMQQHSGQHLITAVADDLFGLKTTSWELGRLRSVIELDSPTVTAEQVAAIERSVNEKIRDRLPVNVRELSLDDPEVEQVRGRGLPDDHAGPIRVVTIESVDSNMCCGTHVSNLSDLQVIKILGTEKGKKNKTNLIFLAGNRVLKWMERSHGIEKALTALLKCGAEDHVEAVKKLQNSSKLLQKNNLNLLRDLAVHIAHSLRNSPDWGGVITLHRKGGGEASWRSWAACNFPAPFAAWSQVCALCFRKDGDSEFMNIIANEIGSEETLLFLTVGDEKGAGLFLLAGPAEAVETLGPRVSEVLEGKGAGKKGRFQGKATKMSRRAEVQALLQDYISTQSAEE
What is the function of this protein?
Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).
What are the official names of this protein?
Alanyl-tRNA editing protein Aarsd1, Alanyl-tRNA synthetase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSN_AGRRK
Sequence: MTAAVTANVVTLPAAEPAKAVRDTRPLRLITCGSVDDGKSTLIGRLLWDTKAVKEDQAATLQRDSTGKQNDLGLPDFALLLDGLQAEREQGITIDVAYRYFSTDNRSFIVADTPGHEQYTRNMATGASTADLAILLIDARLGILEQTRRHATIASLLGIKQFVLAVNKIDLTNYDRAGFEKIAHDFREFALSLGVKQITAIPMSALKGENVVYSGQAAMPWYNGPTLVETLELATVRSAQSVGFRLSVQRVSRPGESFRGYQGTVAGGSVKPGDSVMILPSGMVANVSKIVTFDLVRNAAVAGDAITLVLDRQVDVSRGDMIVAIDSQPQSGLAFDAQIVALQPEGIEPGKRYWLKSGSRRQRVQVQPIAQLELKTGAWAPAQALWMNAIGKVRLSFDEAAVFDPYDQNRSTGSFILIDPDSNNTIAGGMITGKRTDLGGIHKEGQRVLLSLPADLADQIMASELFASRRDETEVRRVTAAQAADIWANAASDI
What is the function of this protein?
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 1, ATP-sulfurylase large subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Protein: HLDD_ENT38
Sequence: MIIVTGGAGFIGSNIIKALNDKGITDILVVDNLKDGTKFANLVDLNIADYMDKEDFLIQLMAGEEFGEIEAIFHEGACSSTTEWDGKYMMDNNYQYSKEVLHYCLEHEIPFLYASSAATYGGRTSDFIESREYEQPLNVYGYSKFLFDEYVRQILPEANSQIVGFRYFNVYGPREGHKGSMASVAFHLNTQLNNGETPKLFEGSDGFKRDFVYVGDVAAVNLWFWENGVSGIFNLGTGRAESFQAVADAALAFHKKDSLEYIPFPEKLKGRYQAFTQADLTNLRAAGYDKPFKTVAEGVAEYMAWLNRN
What is the function of this protein?
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
What are the official names of this protein?
ADP-L-glycero-D-manno-heptose-6-epimerase, ADP-L-glycero-beta-D-manno-heptose-6-epimerase, ADP-glyceromanno-heptose 6-epimerase, ADP-hep 6-epimerase, AGME.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
Protein: PSBP_WHEAT
Sequence: MASTSCFLHQSTARLAASARPAPAVGRTQLFVCKAQKNDEAASDAAVVTSRRAALSLLAGAAAIAVKVSPAAAAYGEAANVFGKAKKNTDFVAYSGEGFKLMIPAKWNPSKEREFPGQVLRYEDNFDATSNLSVIINPTTKKTITDYGSPEEFLSQVGFLLGQQSYGGKTDSEGGFESDAVATANVLESSAPVVDGKQYYSITVLTRTADGDEGGKHQLITATVADGKLYVCKAQRDKRWFKGAKKFVENAAGSFSVA
What is the function of this protein?
May be involved in the regulation of photosystem II.
What are the official names of this protein?
Oxygen-evolving enhancer protein 2, chloroplastic, OEE2, 23 kDa subunit of oxygen evolving system of photosystem II, 23 kDa thylakoid membrane protein, OEC 23 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the psbP family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane. Note=Associated with the photosystem II complex.
Protein: RS11_ECOL6
Sequence: MAKAPIRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity).
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: RS9_YERPA
Sequence: MAENQYYGTGRRKSSSARVFLKPGSGKIVINQRSLEVYFGRETARMVVNQPLELVDMVTKFDMYITVKGGGISGQAGAIRHGITRALMEYDESLRGELRKAGFVTRDAREVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: UBIA_SALNS
Sequence: MEWSLTQSKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGMPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTVNRPLPSGAVTEKEARNLFVVLVLLAFLLVLTLNAMTILLSVAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESLPLSCWLMFLANILWAVAYDTQYAMVDRDDDIKIGIKSTAILFGRYDTLIIGILQLGVMALMALIGWLNGLGWGYYWAVLVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF2_THEYD
Sequence: MSTKAVRSIELARELGVKPLEIVKFIEKIRNIQFKKGTTNIKVEPDEIDKIIQHFKKEAKLEKIKEKEEKPVELKKTEEIKELEEKKPITPKIIEEEIKEEEELQLPGRFRREISFEKIEKIKPKPVPTKIPPKKFEPKKWLDIKEQKKVKDKNKKEEPAVTPSTAPRKKSIKIEEGTTVKEFAELIGQKVPDVIKKFMELGYMPTINQPVDIDAAQLVAESFGIKVEFSQTQELDIIEEVEDSPELLQPRPPIVTVMGHVDHGKTSLLDAIRKTKVTEQEAGGITQHIGAYKVTLQGKDITFLDTPGHEAFTALRARGAKVTDIVVLVVAADDGVMPQTIEAINHAKAANVPIVVAVNKIDKPEANPQRVRTQLSDYGVIPEEWGGQNIFVDISAKKRIGIENLLEMIALQAEIMELKANPNKPARGTIIESRLDKGRGPVATVIVQNGTLRIGDAFVAGVTYGKVRAIIDDTGKRINEAPPSTPVEVVGFEEVPQAGDSFTVVEDERIARQIANTRAQKKRLAEMQKAQRLTLQDLYEKIKEGEVKELNLVIKGDVQGSVEALKKAVEDITHPEIKVKVIHTGVGGITESDVNLAATANAIIIGFNVRPETKAQDLAEQLGVDIKLYSIIYEVIDDVKKALQGMLEPEIKERVIGRAEVRAVFKISKIGTVAGCYVLNGTISRASDGVRVIRDNIVVYEGKISSLKRFKEDVREVQAGYECGITIENFNDIKEGDILENYVLEKVPVKGL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU4LM_MACNR
Sequence: MIPTYMNIMLAFTISLLGMLTYRSHLVASLLCLEGMMMSLFIMATLMASNTHFPLINIMPIILLVFAACEAAVGLALLISISNTYGLDYIHNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COAD_STRSY
Sequence: MSDKIGLFTGSFDPITNGHLDLIERASGLFDKLYVGVFTNPKKAGLLTGLERKAILEKLFVGMENIEVVLSENELVVDVAKRYGVTHLVRGLRNATDLEYESSFDFYNRQLAPGLETIYLIAKPELKFVSSSQVRELLYFKQDIGPYVPEIVSEEIRKNEEK
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOP56_DICDI
Sequence: MATHILFETATGFNIFQLSGMESIAEFTDQVQKSMQDFSKFSKVCKMVGSLPFTSAENALENINSISEGILTESLHDFLKQTFSKKTEGVVLGVCDNKLSASIGDELKISCLSNSHTSEIIRCIRNHISEFTKLKSADLLKAQLGLGHSYSRSKVKFNVHKVDNMIIQSICLLEQLDKDLNTFFMRLREWYSWHFPELLKIIESQVHFAKLAKLIQNKKNLTEESLDEIKEILEDNESLAKDVLSAAKASMGGDISQIDLVTVMHFADRVISLDEYRTNLTQYLAKKMQDIAPNLSALVGDRIGAKLISRAGSLTSLAKYPASTVQILGAEKALFRAMKVRGKTPKYGIIFNASAVSSETKNKGRIARCLSNKISIATRIDCFSDNPTAKFGVALKQQVADRIKFFNNGVAPKRNLDVMKEVIEEVEKDFAEEEVKPVVKESSSKKRKESEPTEEKSSKKSKKEEKSSKKSKSDDVEMKEEPVKEEKKSSKKSSSKKEEEPVKEEKKSSSKKEDKKEKKESKKDEKEEKKSSKKDKKEKK
What is the function of this protein?
Involved in the early to middle stages of 60S ribosomal subunit biogenesis.  Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.  Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
Nucleolar protein 56, Nucleolar protein 5A.
What is the protein family that this protein belongs to?
Belongs to the NOP5/NOP56 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL1_ECOLC
Sequence: MAKLTKRMRVIREKVDATKQYDINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGRSVRVAVFTQGANAEAAKAAGAELVGMEDLADQIKKGEMNFDVVIASPDAMRVVGQLGQVLGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFDADKLKENLEALLVALKKAKPTQAKGVYIKKVSISTTMGAGVAVDQAGLSASVN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PPE02_MYCTU
Sequence: MTAPIWMASPPEVHSALLSSGPGPGPLLVSAEGWHSLSIAYAETADELAALLAAVQAGTWDGPTAAVYVAAHTPYLAWLVQASANSAAMATRQETAATAYGTALAAMPTLAELGANHALHGVLMATNFFGINTIPIALNESDYARMWIQAATTMASYQAVSTAAVAAAPQTTPAPQIVKANAPTAASDEPNQVQEWLQWLQKIGYTDFYNNVIQPFINWLTNLPFLQAMFSGFDPWLPSLGNPLTFLSPANIAFALGYPMDIGSYVAFLSQTFAFIGADLAAAFASGNPATIAFTLMFTTVEAIGTIITDTIALVKTLLEQTLALLPAALPLLAAPLAPLTLAPASAAGGFAGLSGLAGLVGIPPSAPPVIPPVAAIAPSIPTPTPTPAPAPAPTAVTAPTPPPGPPPPPVTAPPPVTGAGIQSFGYLVGDLNSAAQARKAVGTGVRKKTPEPDSAEAPAAAAAPEEQVQPQRRRRPKIKQLGRGYEYLDLDPETGHDPTGSPQGAGTLGFAGTTHKASPGQVAGLITLPNDAFGGSPRTPMMPGTWDTDSATRVE
What is the function of this protein?
Inhibits nitric oxide (NO) production in activated macrophages (PubMed:23448669, PubMed:28071726).  Acts by inhibiting expression of the host inducible nitric oxide synthase (iNOS) (PubMed:28071726).  PPE2 is translocated into the host macrophage nucleus, where it interacts with a GATA-binding site overlapping with the TATA box of NOS2 (iNOS) promoter, and strongly inhibits NOS2 gene transcription (PubMed:28071726).  Reduction in NO production in turn facilitates intracellular survival of the bacilli inside the macrophage (PubMed:28071726).  In addition, disrupts the assembly of NADPH oxidase complex, which inhibits NADPH oxidase-mediated reactive oxygen species (ROS) generation in macrophages and favors M. tuberculosis survival (PubMed:31375544).  Acts by interacting with NCF2, the cytosolic subunit of NADPH oxidase, and preventing translocation of NCF2 and NCF1 to the membrane, which causes a reduction of the functional assembly of NADPH oxidase complex and a decrease in NADPH oxidase activity (PubMed:31375544).
What are the official names of this protein?
PPE family protein PPE2.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Host nucleus. Note=Translocated into the macrophage nucleus via the classical importin alpha/beta pathway.
Protein: Y0585_STAHJ
Sequence: MTELNGRVAIITGASSGIGAATAKALEKQGVKVVLAGRSHDKLNTLAKDMNEDNIHIVPTDVTNQVEVDALVAKVIDVFGHVDIFVNCAGVMRSSKITDYQVESWDSMVDTNIKGLLYSLNAILPKFEAQGSGHVVNLASISANEVSKESALYSATKSAVLMIFNGLEKELAKTGIKTTSILPGMVDTPMTERSDFGGRKKLDPENIADAIIYALTQPAHVNVNEVTVRPV
What are the official names of this protein?
Uncharacterized oxidoreductase SH0585.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RLMM_SALAR
Sequence: MNKVVLLCRPGFEKECAAEITDKAGKRELFGFARVKENTGYVIYECYQPEDGEKLISELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELMKFCRKFTVPLRAALRDAGVLTHYETPKRPVVHVFFIAPGCCYTGYSLAHNHSPFYMGIPRLKFPSDAPSRSTLKLEEALHVFIPEDEWDERLANGMYAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFRYRPNRNNISWMVCDMVEKPAKVTALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYLQAQLDEHGVNAQIQARQLYHDREEVTVHVRRLWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NMDE3_MOUSE
Sequence: MGGALGPALLLTSLLGAWAGLGAGQGEQAVTVAVVFGSSGPLQAQARTRLTPQNFLDLPLEIQPLTIGVNNTNPSSILTQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRWDHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKSGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICHNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPSSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSPDLTAGSAQANVLKMLQAARDMVSTADVSGSLDRATRTIENWGNNRRAPAPTTSGPRSCTPGPPGQPSPSGWRPPGGGRTPLARRAPQPPARPATCAGSPQPDVSRASCRHAWDARWPVRVGHQGSHLSASERRALPERSLLHAHCHYSSFPRAERSGRPFLPLFPEPPEPDDLPLLGPEQLARREALLRAAWARGPRPRHASLPSSVAEAFTRSNPLPARCTGHACACPCPQSRPSCRHVAQTQSLRLPSYREACVEGVPAGVAATWQPRQHVCLHTHTHLPFCWGTVCRHPPPCSSHSPWLIGTWEPPSHRGRTLGLGTGYRDSGVLEEVSREACGTQGFPRSCTWRRISSLESEV
What is the function of this protein?
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium.  Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365).  Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365).  Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex (PubMed:27922130).  Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (PubMed:8987814).
What are the official names of this protein?
Glutamate receptor ionotropic, NMDA 2C, GluN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: AROK_SALSV
Sequence: MAEKRNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADVGWVFDVEGEDGFRNREEKVINELTEKQGIVLATGGGSVKSRETRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQVEAPPREVLEALANERNPLYEEIADVTIRTDDQSAKVVANQIIHMLESN
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase 1, SK 1.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYR_BRUSI
Sequence: MNIFADFDARIKKTLQDIDLKQKDGGELDLSRIGVEPPRDASHGDIATNAAMLLSKAVGQNPRELAARIAEALKADEDVESVDVAGPGFINLRLKASYWQRELLVMLNEGTDFGRSRLGAGKKVNVEYVSANPTGPMHVGHCRGAVVGDVLANLLKFAGYDVVKEYYINDAGAQIDVLARSVMLRYREALGESIGEIPAGLYPGDYLVRVGQELAGEFGTKLLEMPEAEALAIVKDRTIDAMMAMIRADLDALNVHHDVFYSERKLHVDHARAIRNAINDLTLKGHVYKGKLPPPKGQLPEDWEDREQTLFRSTEVGDDIDRPLMKSDGSFTYFAGDVAYFKDKYDRGFNEMIYVLGADHGGYVKRLEAVARAVSDGKAKLTVLLCQLVKLFRNGEPVRMSKRAGEFITLRDVVDEVGRDPVRFMMLYRKNDAPLDFDFAKVTEQSKDNPVFYVQYASARCHSVFRQAADQLGLVDLDRVAMGSHFEKLTDESEIALVRKLAEYPRLIESAAIHQEPHRLAFYLYDLASSFHSQWNRGTENPDLRFIKVNDPDLSLARLGLVQVVSDVLTSGLTIIGADAPTEMH
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1492_PROMH
Sequence: MSNLCPCNSQLPYSECCEPYLLGTKNAPTAQALMRSRYSAFVTHNADHLIKTWHPSCRTPSLRDELIATFPNTQWLGLHIISAQENPRDNEAFVEFSACFIEINADDKQYLHERSRFLKIDDCWFYIDGVQPKVGRNDPCPCGSGRKYKKCCEHNRK
What are the official names of this protein?
UPF0225 protein PMI1492.
What is the protein family that this protein belongs to?
Belongs to the UPF0225 family.