PharMolix/UniProtQA huggingface dataset:
Protein: MBD5_ARATH
Sequence: MSNGTDQAQPPPENPATPVDSKSRKRATPGDDNWLPPDWRTEIRVRTSGTKAGTVDKFYYEPITGRKFRSKNEVLYYLEHGTPKKKSVKTAENGDSHSEHSEGRGSARRQTKSNKKVTEPPPKPLNFDFLNVPEKVTWTGINGSEEAWLPFIGDYKIQESVSQDWDRVFTLVTSQNAGKTMF
What is the function of this protein?
Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides.  In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C).  Plays probably a role in gene silencing.
What are the official names of this protein?
Methyl-CpG-binding domain-containing protein 5, AtMBD5, MBD05, Methyl-CpG-binding protein MBD5.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with heterochromatin, and particularly at perinucleolar chromocenters.
Protein: HIS1_VESOH
Sequence: MLTITLSKGRILKQTLPLLEQAGLIIAKQELNSRKLILDTNLTDVKVIIVRSTDVPVFVQHGATDMGIAGKDVLLEHGANNLFEVLDLGIAKCKLMVAAESKNRLKQNTLKVATKYVNSTKRYFQNKGQSCEIIKLYGAMELAPKVGLAHCIVDLVDTGNTLKANGLIPFEYIEKISSRLVVNVASFRTKNAQIKSWIQNIENSL
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANE_ECO27
Sequence: MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLALVKTLSDAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTVMKKAVL
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: LEUC_BRUA1
Sequence: MSAPRTLYDKIWDDHVVDQQEDGTCLLYIDRHLVHEVTSPQAFEGLRMAGRPVRHPEKTLAVVDHNVPTSPDRINGIQNEESRIQVEALARNAADFGVEYYSERDKRQGIVHIVGPEQGFTLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLIQKKAKNMLVRVDGKLPAGVTAKDIVLAIIGEIGTAGGTGYVIEYAGEAIRSLSMEGRMTICNMSIEGGARAGLIAPDETTFEYIKGRPRAPQGETLEQAINYWKTLHSDEGAHFDKIVTLDAGSLPPIVSWGSSPEDVVSVTGVVPNPDDIADETKRASKWRALDYMGLKPGTKITDIAVDRVFIGSCTNGRIEDLRAAAKVVEGKKVAPTVNAMIVPGSGLVKEQAEAEGLHKIFIEAGFDWREPGCSMCLAMNDDRLKPGERCASTSNRNFEGRQGFKGRTHLVSPAMAAAAAIAGHFVDIRAWK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: SYC_THEON
Sequence: MAIRVYNTLTKQKEEFRPLREGEVRMYVCGPTVYDYTHLGHARTYIAFDVIRRYLEHRGYTVLMVMNFTDIDDKIIRRANETGEDPKELAEKFLRYFLEDMKALKVKPADIYPRVTEHIQDIIDFVRKLQEKGYAYEGNDGVYFEVRKFKDYGKLSGIKLEELVKGARVEPGEGKKNPEDFALWKKAKPGEPKWESPWGEGRPGWHIECSTMSTKYLGESFDIHGGGNDLIFPHHENEIAQSEACTGHEWVRYWLHTGFVMVSGEKMSKSLGNFVTIRELLQKYSPEVIRFFVLQKHYRSPLDYTEEGIQHAKNNLERLYNTLENIRVAMEKADVAFRWDEEEFELYETVREARKKFYDAMDDDFNTAEALKAVFEVSNAVNRYLTKVEKPKESVLRKALEFFKIVSEVFGLFEDYFKEQKAGDEEALIELLVSVRAELRKQRNFTLADKIRDELKALGIQLEDTPQGTIWKRISV
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLDH_STAAS
Sequence: MVVGDFPIETDTIVIGAGPGGYVAAIRAAQLGQKVTIVEKGNLGGVCLNVGCIPSKALLHASHRFVEAQHSENLGVIAESVSLNFQKVQEFKSSVVNKLTGGVEGLLKGNKVNIVKGEAYFVDNNSLRVMDEKSAQTYNFKNAIIATGSRPIEIPNFKFGKRVIDSTGALNLQEVPGKLVVVGGGYIGSELGTAFANFGSEVTILEGAKDILGGFEKQMTQPVKKGMKEKGVEIVTEAMAKSAEETDNGVKVTYEAKGEEKTIEADYVLVTVGRRPNTDELGLEELGVKFADRGLLEVDKQSRTSISNIYAIGDIVPGLPLAHKASYEAKVAAEAIDGQAAEVDYIGMPAVCFTEPELATVGYSEAQAKEEGLAIKASKFPYAANGRALSLDDTNGFVKLITLKEDDTLIGAQVVGTGASDIISELGLAIEAGMNAEDIALTIHAHPTLGEMTMEAAEKAIGYPIHTM
What is the function of this protein?
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.
What are the official names of this protein?
Dihydrolipoyl dehydrogenase, Dihydrolipoamide dehydrogenase, E3 component of pyruvate complex, Membrane-bound ribosome protein complex 50 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: 3MGH_RICCN
Sequence: MNKLIPVPREFFARDTNVVSTELIGKALYFQGKTAIITETESYIGQNDPACHAARGRTKRTDIMFGPAGFSYVYLIYGMYYCLNFVTEAKGFPAATLIRGVHVILPENLYLNGPGKLCKYLGINISHNKCDLINNNEFFVGDIGLKLPYSTTARIGITKGTDKLWRYVVTDITNLISQYNVQP
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: TYSY_RHIME
Sequence: MRQYLDLLEHVITTGTDRGDRTGTGTRSVFGYQMRFDLSQGFPVLTTKKLHLRSIIHELLWFLRGDTNVAYLKDNGVSIWDEWADENGELGPVYGYQWRSWPTPDGRHIDQIAALVEGLKTNPNSRRHIVSAWNPALVDEMALPPCHCLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMVAQVTGLEAGDFVHTLGDAHIYRNHFEQAQLQLTRTPKPLPKMEINPAVKDIFSFRFEDFELVGYEADSHIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y02A_BPT4
Sequence: MHIVLFKPTPYNVRKNTQFKALIADTWELVLDIPAEESPPFGRVEFIKFAVRPTKRQIRQCKRYFRKIVKLEKQFVTCDYAEILK
What are the official names of this protein?
Uncharacterized 10.2 kDa protein in sp-Gp41 intergenic region.
Protein: RS6_LACP3
Sequence: MAETKYEVTYIIRPDLDDAAKTELVERFDNILKENGANIIDSKDWQKRKLAYEINKYNEGLYHIVNLSAEDDKAINEFDRLGKINNDILRHMIVKRED
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: ERG24_HUMAN
Sequence: MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY
What is the function of this protein?
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
What are the official names of this protein?
Delta(14)-sterol reductase TM7SF2, Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, Another new gene 1 protein, C-14 sterol reductase, C14SR, Putative sterol reductase SR-1, Sterol C14-reductase, Transmembrane 7 superfamily member 2.
What is the protein family that this protein belongs to?
Belongs to the ERG4/ERG24 family.
What are the subcellular locations of this protein?
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NDK_HYPBU
Sequence: MPVERTFVMIKPDGVKRGLVGEIIARFERKGLKIKALKMKWLTREEAEKLYEVHRGKPFFEDLVNFVTSGPVVAMILEGDSAIEVVRLMIGPTDGRKAPPGTIRGDYALDIGANVIHASDSKESYEREYKVFFSDDEIVGDY
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC_CANGA
Sequence: MSEKKGATLFKTRCLQCHTVEKGGPNKVGPNLHGIFGRKSGQAAGYSYTDANIKKNVTWDEDNMSDYLTNPKKYIPGTKMAFGGLKKEKDRKDLIAYLKKATSD
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: LEUC_NITWN
Sequence: MSQPTTLYDKIWNDHLVHEAEDGTCLIYIDRHLVHEVTSPQAFEGLRVAGRKVHAPEKTLAVVDHNVPTTDRSKPNPDPESAEQIAALAQNARDFGIEYYNEFDKRQGIVHVIGPEQGFTLPGTTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLIQKKAKNMRAVVDGKLPDGVTAKDIILAIIGEIGTAGGTGYVLEYAGEAIRALSMEGRMTVCNMSIEGGARAGLIAPDETAYEFLKGRPKAPKGADWDAALRYWETLRSDDGAHFDHEIRLDAAKLPPIVTWGTSPEDVIAVTGKVPDPAAIEDEAKRLSKERALHYMGLLPGTKITDIRLDRVFIGSCTNGRIEDLRAAAKIAEGRTVNGNVSAMVVPGSGLVKEQAEAEGLDKIFTRAGFEWREPGCSMCLAMNPDKLKPDERCASTSNRNFEGRQGFKGRTHLVSPSMAAAAAIAGHFVDIREWR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: YWMD_BACSU
Sequence: MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQKTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLHPYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDPAAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKEAQKFTE
What are the official names of this protein?
Uncharacterized protein YwmD.
What is the protein family that this protein belongs to?
To B.subtilis YwmC.
Protein: MTNA_CARHZ
Sequence: MDTMYWKDNTLFLLDQTKLPIEVKYVKLKTYEEVAEAIVSMKVRGAPAIGAAAAYGMVLGVMGYRNDQNLEVYLKNVYETLKNTRPTAVNLFWALDRMWKKYLEVKNQTFEEIANALLNEANSIFYEDIELNKKIGAYGLEVVPENASILTHCNAGALATAGYGTALGVVRAAFEAGKLRKVFADETRPLLQGARLTAFELLEDGIDVTLICDNMAGYVMSLGLVDLVVVGADRVTANGDVANKIGTYSLAILAKEHGIPFYVAAPYSTIDLNLTSGQDIPIEERNPDEVRKIGDRLIAPPQVKVFNPAFDVTPAKYITGIITDRGIVRPPYKENIKKLFGGK
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: GLRX_VIBCH
Sequence: MFVVIFGRPGCPYCVRAKEHAETLKAKRDDFNYRYVDIHAEGITKADLEKTIGKPVETVPQIFIDEQHIGGCTDFEAYAKENLGLFD
What is the function of this protein?
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase.  Reduces low molecular weight disulfides and proteins (By similarity).
What are the official names of this protein?
Glutaredoxin.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NG3_DROME
Sequence: MRYSCVLLLLATVACLLIPQTGGSTATTTSTSASATTTTSASATTTTASDTTTTTAATTTTSSSSSKSKKKKRTYHYTRHVYRPKRIRHIYRHKADDDESSTDRTSTRSRRRRRSSSSSSSSGSTSSRSGNSRIRRRRARSARRLS
What are the official names of this protein?
Protein new-glue 3, NG-3.
What are the subcellular locations of this protein?
Secreted.
Protein: SHDAG_HDVL1
Sequence: MSRSESKKNRGGREEVLEQWVNSRKKAEELERDLRKTKKKIKKLEDDNPWLGNIKGILGKKDKDGEGAPPAKRARTDQMEVDSGPRKRPLRGGFTDQERQDHRRRKALENKKKQLAGGGKNLSREEEEELGRLTEEDEKRKRRVAGPPTGGVNPLEGGQRGAPGGGFVPSMQGVPESPFHRHGEGLDARGDRGFP
What is the function of this protein?
Promotes both transcription and replication of genomic RNA.  Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal.  May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA.  RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity).
What are the official names of this protein?
Small delta antigen, S-HDAg, p24.
What is the protein family that this protein belongs to?
Belongs to the hepatitis delta antigen family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: HSLV_XANCP
Sequence: MDPSQNPNVVHATTIISVRRGGHVAVAGDGQVTLGHTVMKGNARKVRRLGRDGQVLAGFAGAAADAFTLFELFEAKLDKHGQLTRAAVELAKDWRTERRLGKLEALLAVADKETSLIISGTGDVIEPEDGIIAIGSGGSYALSAARALLAHTELDAKTIATEAINIAGDICIYTNRNVVVEEL
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEN1_PLAVS
Sequence: MGIKGLTKFIADAAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRKQNEEAKKLLTLMGIPVVEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNANASSANQNKNKNSSKRGYILTEINLEQVLKGLNLSMNEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNSIEKIIENIDKNKYQVPSNFRFVEARDSFINPKVLPKEEVKIDWCEPKIEELKNFLIKDYNFNEVRVTNYINRLLKARKVTTQRRLDNFFTACTKKSTKLVIEESQSQSKTQKEAKSKRKGKKRDAPNDGAAKLNSKQSKKTKVEKEPKREKKDEEAPNGEAHNGDNNEDEETPGMGARDPFDTDDEEDNPSPNFFHQKSDSESGNVKKEKTEQEGNATTAGDVYNYPNGKDTAGSNTHLSSNSTLHSCNNVGSEKAPNEGMHTVGSSAPEAGTNHVGINHVGTNHVGINHVGTNHVGTNHVGSGDLFPPNVADCANNNADKAQPEMKKKNMLFLLPYCPKNVTNVKKRKSVQRC
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: FTCR_BRUO2
Sequence: MIVVVDDRDMVTEGYSSWFGREGITTTGFTPTDFDEWVESVPEQDIMAIEAFLIGECADQHRLPARIRERCKAPVIAVNDRPSLEHTLELFQFGVDDVVRKPVHVREILARINAIRRRAGASATSGADGTQLGPIRVFSDGRDPQINGIDFPFPRRERRILEYLIANRGRRLNKVQIFSAIYGIFDSEVEENVVESHISKLRKKLRGQLGFDPIDSKRFLGYCINIE
What is the function of this protein?
Required for transcription of flagellar genes.
What are the official names of this protein?
Flagellar transcriptional regulator FtcR.
Protein: FABZ_BART1
Sequence: MISTEGIKDLEAVDIEKLLSILPHRYPFLLIDRIVNIDGEQEAIGIKNITINEPHFTGHFPTKPVMPGVLILEAMAQTAGAIALLNLGNKRTNLVYLMTVDNAKFRKPVMPGDQLKIHVQLLKKRSGMRRFSCVAKVENVRVAEAEIAAMIVEEE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB1_LIGS1
Sequence: MIEVALGAGLGASVRYLITQVLKSKTRVFPWATFIINITGALLLGFLHSKITSSHILLLLGTGFLGGYTTFSTFQVELVTLVNNRKQKMMIIYLLLTVICGILAAYCGSWLGKL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: C82D6_SINHE
Sequence: MDSLHCLETLLLGFFVLLPCFFYFVWKKPNNKIKEPPQPAGAWPIIGHLHLLARGDLPHKILSSFADKNGPVFKIQLGVHQALVVNNSEIAKECFTTNDRFFLNRPSGVAAKIMGYNYVMLGVAPYGPYWRDMRKIIMLEFLSNRRLQSLKHVWHSEISISSKELYKLWETQNIDFCLVDMKQWLADLTLNMSVKMVVGKRFFGSASASACEETESSNCPKTLRNMFRLMGSFVLSDYLPYLRWLDLGGHEKEMKRTVKELDILFKGWLDEHKRKRLSGGKEDDDQDFMDVMLSILEESKLGNDVDTINKTACLAIILGGADTTWATLTWALSLLLNNPNALKKAQDELDLHVGRDRNVDESDLVKLTYIDAIIKETLRLYPPGPLLGPRVVTEDCTIAGYHVRAGTRLIVNAWKIQRDPLVWSQPHEYQPERFLERDVDMKGQHFELIPFGSGRRACPAISLALQVLPLTLAHILHGFELRTPNQNKVDMTETPGIVHAKATPLEVLVAPRISPKCFV
What is the function of this protein?
Cytochrome P450 involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family (PubMed:26359402).  Catalyzes the hydroxylation of deoxypodophyllotoxin to form epipodophyllotoxin (PubMed:26359402).
What are the official names of this protein?
Demethylepipodophyllotoxin synthase, Cytochrome P450 family 82 subfamily D polypeptide 61.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NANE_ECO57
Sequence: MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANLQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLTLVKRLSDAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL
What is the function of this protein?
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
What are the official names of this protein?
Putative N-acetylmannosamine-6-phosphate 2-epimerase, ManNAc-6-P epimerase.
What is the protein family that this protein belongs to?
Belongs to the NanE family.
Protein: KTHY_PROM5
Sequence: MKGKFIVIEGIDGCGKTTQIDEISRWLPTSGLMGKNSKLIKTREPGGSLLGKKLRNLILDNNKNNKPSSLAELLLYSADRAEHVSKIISPALKKEDWVISDRFSDSTLAYQGYGRHINLEIIKNIESIVCQGEYPDLTIFLEISAEESILRRKNFVPDRMESEGINFLQKVNEGFKLIAKEKKWKVISATQNITAISNEIKETLLKTFRN
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: SYW_METMA
Sequence: MDNKLDPWSSSNITDYSKLFEEFGISPFENILPEIPSPHKYMRRRIIFGHRDYEQIAEAMRTGAPFSVMDGFMPSGKVHLGHKMVMDQIVWHQEKGASAFVGIADREAFSVRGFSWQKCREIGVEEYILSLIALGFKPEGLIYFQSGCGSVKDLAFELGAKVNFSELSAIYGFSGETSLSHMLSVATQAADILQPQLEEFGGSKPVVVPVGPDQDPHLRLTRGLAGKMNMFRVEERETAEGGKYLSVRGKGAPREALQELKKRIPGKVKLYEEHIDVLQTPDYAFLERFVLQINQPERRNYFMTQIQEIATFANAAKPPEFSEYEKYFVFKRVWKTTGKILEEVVAEVAAEFDGYAFIPPASTYHRFMSGLQGGKMSSSIPDSHIALTDDPKEGAKKVKRAKTGGCITLEEQKKLGGKPDECSVFELMLFHLIEDDEELLEIREECIYGTRMCGSCKQLAAEKMQEFLKDHQEKRELAREQLDEYRIIYKK
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CADH2_RAT
Sequence: MCRIAGGPRTLLPLLAALLQASLEASGELALCKTGFPEDVYSAVLPKTVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLSAEQAKFLIYAQDKETQEKWQVAVNLSLEPSLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINITALDYDIDPNAGPFAFDLPLSPATIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIVITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGTIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD
What is the function of this protein?
Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell.  Cadherins may thus contribute to the sorting of heterogeneous cell types.  Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence.  Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity).  Required for proper neurite branching.  Required for pre- and postsynaptic organization (By similarity).  CDH2 may be involved in neuronal recognition mechanism.  In hippocampal neurons, may regulate dendritic spine density.
What are the official names of this protein?
Cadherin-2, Neural cadherin, N-cadherin.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane, sarcolemma. Cell junction. Cell surface. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes (By similarity). Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes (By similarity).
Protein: COFH_METTH
Sequence: MNIKTRTKKILQKAMDEPITKEEALYLMGVTGRDLQALMIAADMVREAEAGDRITYIENWNINFTNICSGQCGFCAFKRDAADGDSYYLETERILEIAAEAIEKGARELCIQGGLYPGLDTYFYEDLIRAIKSEFPDVHLHSFSPMEVYYGAQNAELTVEEALKILKRAGLGSMPGTAAEILDDDVRAVICPTKLSTGEWVEVIETAHRVGIPTTCTMMYGHIDGPEHRVEHMDILRRIQEKTGGFTEFVPLPFMHPHAPIYREGLAMPGATGADDLKVYAISRLMFRGLIENIQASWVKLGFKFAQVALLSGANDIGGTLGEENISKSAGASHGVRTEPEEIIRVVRDIGRIPARRDTLYREIEDV
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
What are the official names of this protein?
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase, FO synthase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofH family.