PharMolix/UniProtQA huggingface dataset:
Protein: DNJB1_HUMAN
Sequence: MGKDYYQTLGLARGASDEEIKRAYRRQALRYHPDKNKEPGAEEKFKEIAEAYDVLSDPRKREIFDRYGEEGLKGSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGRNPFDTFFGQRNGEEGMDIDDPFSGFPMGMGGFTNVNFGRSRSAQEPARKKQDPPVTHDLRVSLEEIYSGCTKKMKISHKRLNPDGKSIRNEDKILTIEVKKGWKEGTKITFPKEGDQTSNNIPADIVFVLKDKPHNIFKRDGSDVIYPARISLREALCGCTVNVPTLDGRTIPVVFKDVIRPGMRRKVPGEGLPLPKTPEKRGDLIIEFEVIFPERIPQTSRTVLEQVLPI
What is the function of this protein?
Interacts with HSP70 and can stimulate its ATPase activity.  Stimulates the association between HSC70 and HIP.  Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401).  Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
What are the official names of this protein?
DnaJ homolog subfamily B member 1, DnaJ protein homolog 1, Heat shock 40 kDa protein 1, HSP40, Heat shock protein 40, Human DnaJ protein 1, hDj-1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
Protein: SYA_PSYIN
Sequence: MIKSTNEIRQGFRDFFVNKGHQSVSTGSLVPHDDPTLLFTNAGMNQFKDTYLGTEKRAYTRATSSQCCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKREAIGFAWEYLTVELGLPKDKLWVTVFDEDLEAEKIWIEEIGVDPKCVLRIGAKDNFWSMGDTGPCGPCSEIFYDHGEDVWGGPPGTAEEDGDRFIEIWNIVFMQYNRHADGTMENLPKPSVDTGMGLERISAIMQNCHSNYEIDLFQGLIKKVAEVTGASDLEDKSLRVVADHIRSCGFLICDGVMPSNEGRGYVLRRIIRRAVRHGHKLGAKDIFFFKIYDELINQMGDAYPELSKQRLFVEKILRREEEQFAKTLDRGLQILDNELDHLEGQVIPGDVVFKLYDTFGFPADLTADIARERGLTIDEAGFDKAMAEQRKRAQQANNFGIDYNKTLIIDQKTEFIGYETLQGAATVTHLVVEGAFVNALKEGDSGQVILSATPFYAEAGGQSGDAGKLILNNGVFVVTDTKKSGDAFVHSGYVGMGSVKVNDKVHAEVDTARRQSIALHHSATHLLHAALRKTLGEHVTQKGSLVDADKLRFDFSHFEALSADSLSEVTFLVNEAIRNNYEVVTKLMDIEEAKSSNAMALFGEKYDEMVRVVQMGDFSTELCGGTHAKRTGDLGLFLIRSESGIAAGVRRIEATVGSAADQVISELLYEVDKACGLVRGDHVNLGEKIEQLVDRSKLLEKEVAELKAKIASAAGANLIDNAIEINGVKVVIANIEGIDPKLLRDSVDQMKNKMQSGIVVLATVAADDKVSLIAGVSKDLIKKVKAGELVNLVAGPVGGKGGGRPDMAMAGGNNPAALADALALVAPWLSERL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_PELUB
Sequence: MITIEDFKIKHTNKVRFIGLDLGSKRIGVSICDERQSIATPFKTINKTNTNELIDELKIIIKDNNIGGIIVGNPVNMDGSLGRSAQSVNDVASNISKSIDLPVILWDERLSTVGAFNLSSLLDVNVSKRVKTIDQNAAAFILQGAIDFLNN
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_VESOH
Sequence: MKILNLDLGYKSYPIYIGQNLLLKGELLTKHISGKQVMIVTNTTVAPLYLKKVQNLLLSFEFAQVILPDGEKYKTLDTVNCIFSALLEKRFDRSCTLIALGGGVVGDMTGFVAASYQRGVNFIQIPTTLLSQVDSSVGGKTGVNHMLGKNMIGAFHQPKCVLIDIYTLDTLDSQQYSSGMAEVIKYGLLVEYLNFFNFLQENIKDLMDRKQSLIIEMIYQSCQHKINIVAQDELEMGKRTLLNLGHTFGHAIENTLGYGTFLHGEAISVGILMATRLSQLEGYLSSKQVAKIQDLLEKANLPISIIGKINASAFMKAMLVDKKVINGNIRLILLKRLGQAFICDNYNNHLLDQVVNEFCQ
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBAB_SALHS
Sequence: MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein YbaB.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ARGR_COLP3
Sequence: MSGLQKQEALVQEFKDLLKQEQFGSQGEIVDALKANGFDNISQSKISRMLSKFGAVRTRNARQEMVYCLPAELGVPTAQSPLKQLVLEIEHNEVMIIIQTSPGAAQLIARLLDSLSKSDGVLGTIAGDDTIFIAPSDVSKINETIKKLEQLFSKNLT
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_ORITB
Sequence: MNKMLYIKTYGCQMNVYDSNRMVDLLETQGYNIVANMADASVIILNTCHIREKASEKMYSELGRIKKLQQSRLKAGKSKAKIIVAGCVGQAEGEEIFIREPAVNIIVGPQSYYNLPTMLEKLDSGTENHLIDLDFVEAAKFNKLPEVLKSPTVSGLVSVQEGCDKFCTFCVVPYTRGAEFSRPLEQVYREVLNIAQQGAKEVVLVGQNVSAYHGKDENGKECSLADLIKYVAKIDKIKRIRYITSHPNDMTDQLLSLHATEEKLMPFLHLPVQSGSNKILKLMNRRHTRERYLEIIQQLRELRPDIVISSDIIVGFPGEDDEDFEATLSLAKEAKFGQCYSFKYSQRPGTPAAVKQQISEEVKQHRLSILQAQLMLQQLECNQKLIGKVVPVLFDRDGKYDGQIIGKTPYMQSVCIMNEKDNNLYGKIVNVKILSASASSLFGEVCPNS
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD_CORJK
Sequence: MRLVLLGPPGAGKGTQASLLSDALKVPHISTGDLFRANISQGTDLGKQAQEYMDAGKLVPTSVTADMVRDRLNQEDAADGFLLDGFPRTIEQAELLEKMLQDDGHSLDAVINYVVSEDVVVDRMLARGRNDDNEDTIRTRLEVYRNETAPLIDHYKDVLLNIDAEGTVEDISCTTLNALDK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBG_MYCTO
Sequence: MKGSSVPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNNRDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSAISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVLVHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEARELAEFVRDDIAQRGWPVFCVSTATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGARSGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XY11A_CELJA
Sequence: MKLPTLGKCVVRTLMGAVALGAISVNAQTLSSNSTGTNNGFYYTFWKDSGDASMTLLSGGRYQSSWGNSTNNWVGGKGWNPGNNSRVISYSGSYGVDSSQNSYLALYGWTRSPLIEYYVIESYGSYNPASCSGGTDYGSFQSDGATYNVRRCQRVNQPSIDGTQTFYQYFSVRNPKKGFGNISGTITFANHVNFWASKGLNLGNHNYQVLATEGYQSRGSSDITVSEGTSGGGTSSVGGASSSVNSSTGGGSSGGITVRARGANGSEHINLRVGGAVVANWTLGTSFQNYLYSGNASGDIQVQFDNDASGRDVVVDYIIVNGETRQAEDMEHNSAVYANGRCGGGSYSENMHCNGEIGFGYTYDCFSGNCSGGNGGSNSSAGNSSSGNTGGGGSNCSGYVGITFDDGPNSNTATLVNLLRQNNLTPVTWFNQGNNVASNAHLMSQQLSVGEVHNHSYTHPHMTSWTYQQVYDELNRTNQAIQNAGAPKPTLFRPPYGELNSTIQQAAQALGLRVVTWDVDSQDWNGASAAAIANAANQLQNGQVILMHDGSYTNTNSAIAQIATNLRAKGLCPGRIDPNTGRAVAPSSSGGSSSVALSSSSRSSSSAGGNTGGNCQCNWWGTFYPLCQTQTSGWGWENSRSCISTSTCNSQGTGGGGVVCN
What is the function of this protein?
Endo-acting xylanase which specifically cleaves internal linkages on the xylan backbone, releasing xylooligosaccharides.  Is able to hydrolyze oat spelt xylan and the arabinoxylans from wheat and rye, releasing xylobiose as the major product.  Also likely catalyzes, via its C-terminal domain, the removal of acetyl groups from acetylated xylan.  Thus, has the capability of hydrolyzing acetylated xylan.  Does not attack mannan, galactan, arabinan or any cellulosic substrates.
What are the official names of this protein?
Bifunctional xylanase/xylan deacetylase, XYLE.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the glycosyl hydrolase 11 (cellulase G) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURG_STRPD
Sequence: MPKKILFTGGGTVGHVTLNLILIPKFIKDGWEVHYIGDKNGIEHTEIEKSGLDVTFHAIATGKLRRYFSWQNLADVFKVALGLLQSLFIVAKLRPQALFSKGGFVSVPPVVAAKLLGKPVFIHESDRSMGLANKIAYKFATTMYTTFEQEDQLSKVKHLGAVTKVFKDANQMPESTQLEAVKEYFSRDLKTLLFIGGSAGAHVFNQFISDHPELKQRYNIINITGDPHLNELSSHLYRVDYVTDLYQPLIAMADLVVTRGGSNTLFELLAMAKLHLIVPLGKEASRGDQLENATYFEKRGYAKQLQEPDLTLHNFDQAMADLFEHQADYEATMLATKEIQSPDFFYDLLRADISSAIKEK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SELO_NOSP7
Sequence: MTLAETPNYKNSSNPLLSLNYESALESLGDDYYDEVAAAEFPQHILRWRNDALLPRLGLDPQVVKDEDFITAFGQFQGRKPLLALRYHGYQFGEYNGQLGDGRGFLYGQVRATDGELYDFGTKGSGRTPYSRGGDGMLTLKGGVREVLAAEALHHLGVRTSRCLTMIETGLPLWRGDEPSPTRSSVMIRMSSSHIRFGTFERLHYFQRPDLTKKLLDHVIEQYYRHLSSEQDKYVLFYAELVKRVAELVAQWMAAGFCHAVLNTDNMSITGESFDYGPYAFIPTYNPSFIAAYFDYYGRYCYGNQPSICKLNLQMLQEPLKAILDKDEMEAALERFDEYYQAEYSSLMLKRLGFVELSYPQAAELLNLTVEFLKDSQVGYHQFFYEMARTFSSKWRDEPGFVMNNSDIVPVPGASGIFDDWCILYHKILNDFDSDRIDVIAQTLAVHNPKTALLRPVIESTWKAIAQEDNWQPFYELIQAIQSRK
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: C99L2_MOUSE
Sequence: MVARLTAFLVCLVFSLATLVQRGYGDTDGFNLEDALKETSSVKQRWDHFSTTTRRPVTTRAPANPAERWDHVATTTTRRPGTTRAPSNPMELDGFDLEDALDDRNDLDGPKKPSAGEAGGWSDKDLEDIVEGGGYKPDKNKGGGGYGSNDDPGSGISTETGTIAGVASALAMALIGAVSSYISYQQKKFCFSIQQGLNADYVKGENLEAVVCEEPQVTYSKQETQSAEPPPPEPPRI
What is the function of this protein?
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane.  Acts at the same site as, but independently of, PECAM1.  Homophilic adhesion molecule, but these interactions may not be required for cell aggregation.
What are the official names of this protein?
CD99 antigen-like protein 2, MIC2-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the CD99 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein; Extracellular side. Cell junction. Note=Concentrated at cell-cell contacts in cultured endothelial cells.
Protein: MNME_SYNAS
Sequence: MLKDTIAAIATPAGTGGIGIVRISGSEAASILNLLFKSSHSVTLFKPRYLYHGDLSDPQTGQVIDEVLVSLMKAPRSYTGEDTLEIYCHGGILVLESVLLAVLRSGARLADPGEFTRRAFLNDRIDLTQAEAVGDVIMARTSKGLEAAVSHLKGQLKQKIDSLRDELIDVQVLLESAIDFTEDVEFPSPSEVLSKLERLSSDLEALLSTYDQGKVYRHGATVVIAGKPNTGKSSLLNCLLQEKRAIVTPVPGTTRDFIEEAISIQGVSVRMIDTAGIHPTDDLIECEGIRMVWEKLATADGVILLLDGSKDLTDEDRKILKRLQGYNLLPVINKADLDHSLKEEDIIACFPGTDPLWVSAKFGEGIAVLKEKIYDLVLEKAGEQDGDVLINSLRHKMALEKTRQQVSQALASLQEGLSQEFAALDIREALEALGEIAGETVTEDILDRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_AZOPC
Sequence: MAKESMKARELKRARLVAKYVDKRVRLKKEGNYDSLQALPKNASPVRLHNRCRITGRSKGYIRQFGISRIQLREMASMGLVPGVRKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: PHSD_ARATH
Sequence: MGEEETIVNDENSSKPKPSPKLTLLPLVFLIFYEVSGGPFGVEDSVKSGGGPLLALLGFLIFPLIWSIPEALVTAELATSFPENGGYVVWISSAFGPFWGFQEGFWKWFSGVMDNALYPVLFLDYLKHSFPVLDHVAARVPALLVITFSLTYLNYRGLHIVGFSAVVLAVFSLCPFVVMALLAVPNIRPKRWLFVDTQKINWRGYFNTMFWNLNYWDKASTLAGEVDRPGKTFPKALFGAVLLVMGSYLIPLMAGTGALSSSTSGEWSDGYFAEVGMLIGGVWLKGWIQAAAAMSNLGLFEAEMSSDAFQLLGMSEIGMLPAFFAQRSKYGTPTISILCSATGVIFLSWMSFQEIIEFLNFLYALGMLLEFAAFVKLRIKKPDLHRPYRVPLNTFGVSMLCLPPSLLVILVMVLAAPKTFLISGVIIVLGFCLYPFLTLVKEKQWARFIPEETRPVSGVSSESQLDEEHGDESAASLLP
What is the function of this protein?
Probable cell membrane polyamine/proton symporter involved in the polyamine uptake in cells.
What are the official names of this protein?
Probable polyamine transporter At3g19553.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ENSA_SALSA
Sequence: MSSENLSDTQMEYEDEKQDSQEKNANLVKGEEVKLKAKYPGLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPVAGPDKNLVTGDHIPTPQDLPQRRSSLVTSKLAG
What is the function of this protein?
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.  When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).
What are the official names of this protein?
Alpha-endosulfine.
What is the protein family that this protein belongs to?
Belongs to the endosulfine family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_KLEP7
Sequence: MRVSQVYRWQIPMDAGVVLRERRLKTRDGLFIRLQEGEREGWGEISPLPGFSVETLEEAQMALLAWAQAWRDGAEPPLPTQPSVAFGISCAQAELGGELPQAADYRAAPLCSGDPDELFARLAAMPGEKVAKVKVGLWEAVRDGMVVNLLLEAIPDLQLRLDANRAWTPLKAQQFAKYVNPAYRQRIAFLEEPCKTREDSRAFSRETGIAIAWDESLREADFRFVAEPGVRAVVIKPTLTGSLQKVQQQVAAAHALGLSVVISSSIESSLGLTQLARIAAWLTPQTIPGLDTLSLMGAQLVRPWPESALPVLNIDALEPLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: RNH_SHESA
Sequence: MTELKLIHIFTDGSCLGNPGPGGYGIVMNYKGHTKEMSDGFALTTNNRMELLAPIVALEALKEPCKVILTSDSQYMRQGITTWIHGWKKKGWMTSNRTPVKNVDLWKRLDKAAQLHQIDWRWVKGHAGHPENERCDQLARAAAEASPTQVDEGYQPES
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUA4_MOUSE
Sequence: MLRQILGQAKKHPSLIPLFVFIGAGGTGAALYVMRLALFNPDVSWDRKNNPEPWNKLGPNEQYKFYSVNVDYSKLKKEGPDF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.  NDUFA4 is required for complex IV maintenance.
What are the official names of this protein?
Cytochrome c oxidase subunit NDUFA4.
What is the protein family that this protein belongs to?
Belongs to the complex IV NDUFA4 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: GRR1_YEAST
Sequence: MDQDNNNHNDSNRLHPPDIHPNLGPQLWLNSSGDFDDNNNNNNNNNNNNSTRPQMPSRTRETATSERNASEVRDATLNNIFRFDSIQRETLLPTNNGQPLNQNFSLTFQPQQQTNALNGIDINTVNTNLMNGVNVQIDQLNRLLPNLPEEERKQIHEFKLIVGKKIQEFLVVIEKRRKKILNEIELDNLKLKELRIDNSPQAISYLHKLQRMRLRALETENMEIRNLRLKILTIIEEYKKSLYAYCHSKLRGQQVENPTDNFIIWINSIDTTESSDLKEGLQDLSRYSRQFINNVLSNPSNQNICTSVTRRSPVFALNMLPSEILHLILDKLNQKYDIVKFLTVSKLWAEIIVKILYYRPHINKKSQLDLFLRTMKLTSEETVFNYRLMIKRLNFSFVGDYMHDTELNYFVGCKNLERLTLVFCKHITSVPISAVLRGCKFLQSVDITGIRDVSDDVFDTLATYCPRVQGFYVPQARNVTFDSLRNFIVHSPMLKRIKITANNNMNDELVELLANKCPLLVEVDITLSPNVTDSSLLKLLTRLVQLREFRITHNTNITDNLFQELSKVVDDMPSLRLIDLSGCENITDKTIESIVNLAPKLRNVFLGKCSRITDASLFQLSKLGKNLQTVHFGHCFNITDNGVRALFHSCTRIQYVDFACCTNLTNRTLYELADLPKLKRIGLVKCTQMTDEGLLNMVSLRGRNDTLERVHLSYCSNLTIYPIYELLMSCPRLSHLSLTAVPSFLRPDITMYCRPAPSDFSENQRQIFCVFSGKGVHKLRHYLVNLTSPAFGPHVDVNDVLTKYIRSKNLIFNGETLEDALRRIITDLNQDSAAIIAATGLNQINGLNNDFLFQNINFERIDEVFSWYLNTFDGIRMSSEEVNSLLLQVNKTFCEDPFSDVDDDQDYVVAPGVNREINSEMCHIVRKFHELNDHIDDFEVNVASLVRVQFQFTGFLLHEMTQTYMQMIELNRQICLVQKTVQESGNIDYQKGLLIWRLLFIDKFIMVVQKYKLSTVVLRLYLKDNITLLTRQRELLIAHQRSAWNNNNDNDANRNANNIVNIVSDAGANDTSNNETNNGNDDNETENPNFWRQFGNRMQISPDQMRNLQMGLRNQNMVRNNNNNTIDESMPDTAIDSQMDEASGTPDEDML
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Recognizes and directs ubiquitination of phosphorylated CLN1, CLN2 and GIC2.  Probably constitutes the primary response element required for the generation or interpretation of the signal that induces glucose repression.
What are the official names of this protein?
SCF E3 ubiquitin ligase complex F-box protein GRR1, F-box and leucine-rich repeat protein GRR1, F-box/LRR-repeat protein GRR1.
What are the subcellular locations of this protein?
Membrane. Note=Associated with the particulate fraction. Probably forms a complex by protein-protein interactions via its leucine-rich segment.
Protein: WAPA_GEOSE
Sequence: MVVWALVMPSVPTKGLAETIRSGIDRVEPKEEPPKVPQAPKRDLKPGEIIEERTENTKVYYNGDGTFTKKIYFEPIHVKKKGQKIFEEVSSSLTDSTNNTNYVETENTILETNFYKKMVDGEYANFHYNGYSISYSILEAAGNDVQSIKAKDVAAVYKKKDNKILHKNIFPSIDLQNITFNESTKEDLVLHSVGYHIFKFRLKTDLQADIQDDGSILLTNQEHEKVFELPKPFMVDSNVDEHSGEVQRLRECNV
What are the official names of this protein?
Wall-associated protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: SYH_HAEI8
Sequence: MAKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLRPEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGRYRQFHQVGVEVFGIANPEIDAELIMLTYRLWKALGIDQHVTLQLNSIGSLEARANYRSALVGFLENHQDLMSDEEKERLVRNPLRILDTKNPELQKVLDNAPKLLDYLDDESRAHFEQLCSLLDAVGIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATPSIGFAMGLERLVLLVQEVNPNVPTKSAVDIYVVYQGEGATLVAFELAEKVRSELPHLNTMLHCSGGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKHLQGGTDQQTLDLVNIIDYLQTQF
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH3_STAA3
Sequence: MANIVFKLSDKDITTLMSRISFDTENLPQGMKARAKYQNTTVNIYQSGKVMFQGNHAEAVSEELLPQHSQLNTNKTKKKNMANSFLEQTLMYDQFNCIGSDEAGSGDYFGPLTVCAAFVTKEHVPILKTLGVDDSKKLTDTKIVELAEQLVTFIPHSLLTLHNEKYNIQQAKGWTQVKMKAALHNEAIKNVLEKIDSSQLDYIVIDQFAKREVYSHYALSDIPLPKKTKFETKGESKSLAIAVASIISRYAFVTYMDQISKNINMTIPKGAGAKVDVIAAKIIKKYGLSRLDTISKKHFKNREKAQKILKPL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP6_PARLI
Sequence: MTMTITVSIFGQFFPETLLFIPMNLFSIVFALSWIAFIYPTNWAPSRFQSIWASFRANVLEMIFQNTSPNTAPWAGLITTVFIVILSANVLGLFPYAFTATSHISLTYSLGFPIWMAVNILGFYLAFNSRLSHLVPQGTPSALIPLMVWIETLSLFAQPIALGLRLAANLTAGHLLIFLLSTAIWLLSSSLMVSSIPIFVIFVLLFILEIGVACIEAYVFTALVHFYLQQNV
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y2011_MYCTU
Sequence: MSDEIARLVADVFELAGLLRRSGEVVAAREGHTQARWQLLSVVSDRALTVPQAARRLGVTRQGVQRVANDLVVCGLAELRHNPDHRTSPLLVLTENGRRVLQAITERAIVVNNRLADAVDPAALQATRDSLRRMIVALKAERP
What are the official names of this protein?
Uncharacterized protein Rv2011c.