PharMolix/UniProtQA huggingface dataset:
Protein: UBID_YERPS
Sequence: MISMKYRDLRDFLSLLEQRGELKRISQPIDPYLEMTEIADRTLRAGGPALLFENPKGYSMPVLCNLFGTAKRVAMGMGQEDVSALRDVGKLLAFLKEPDPPKGFRDLFDKLPKFKQVLNMPTKRLNSAPCQEQVWQGEDVDLSRIPVMHCWPEDAAPLVSWGLTITRGPHKERQNLGIYRQQVLGKNKLIMRWLSHRGGALDYQEWCEAHPGERFPVAVALGADPATILAAVTPVPDTLSEYAFAGLLRGHKTEVVKCLSNDLEVPASAEIVLEGYIEQGDMAPEGPYGDHTGYYNEIDNFPVFTVTHITQRQDAIYHSTYTGRPPDEPAVMGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRLAVVTIKKQYAGHAKRVMMGVWSFLRQFMYTKFVIVCDDDINARDWNDVIWAITTRMDPSRDTVLIENTPIDYLDFASPVSGLGSKMGLDATNKWPAETPREWGRPIKMDEDVRARIDALWDELAIFSDKDAKR
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: EX7S_NOCFA
Sequence: MADSDKDELAEIAGFGYERARDELVNVVKMLEQGGMDLDESLALWERGEALANRCEEHLAGARKRVEDALAGSESDES
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: POLG_PVCV1
Sequence: MTSPSDYQSNSSLATTYSNAPKLSKALSNKYDYLYEVDILKENQKISDTYLPLLNPYSAFAKRSVTPWSQIRSLVQSKPRHVKEYVAASKLDQHPVFATGEEQFVTLHIPEEFASHWKSHQFTHIHFGAVKIALTYHGRKGQPVVARLALLDTRYLEYQHANLGTAEITLNAGTVFITLFPNFTMSLSDANLSTALKIQVQIQGAPLTKDSIQATLHYQIAWRVQNHAMDLTLPGGEEALFLKIDAGSGATQCTQVPRQLSKEDLIKILPDSWVTNYEKLREPEEPLRSTEVSMSKRHDKSVAISFDHSHYKKLRNTHHFMGMISDDVIVLDDPETFSKTLPSLMQTHDWIHHFQLDGRAVSWYKDPFDGHCPWDIDCQCYSCLYSEDEEDFEDGFPTKYKGIPRPGSIAERKMQEEANLKKLYEEKDPFVGSLSRPGKYEYLVRYDAPSWAKDPHLTVEPTGWDSDEPIPPKQPFTTRNTLPKIYMFNPLNYENNFPPLSSFSKDGADHTPKIPKRNVVLPSGAKDPTGDLEATVNWQTENALAQNRMLTTIDRTLKETVTKVDRVTDQSSKNQGLIKVLEQQLQDLNKRICPPGTSLFHFFDQQKSEMASLKEQIRLLKEQPQKNETDTPSYQSSYQPFHSFSSPYMPSNPPNSPFTTFANTPQPQPSLFSQYPIQPKSPNTFDLAKLVWEKKDAIAAEKRAKKKLQKDEVKQKTSLPPESKRPDPQSSSHLGDQFMISDPALPKVYALNEPSVPSEDTSSQSYISTEESVEDTDSFSVVSEESTQLSQLSSSSNDSPENNENTLPQTFMVRPTEPEISEVEDEVDGMTEEPIPERRPEITPPKMVGTGFHTFSLDDISITKWPERIQDFHTWMLTKQLVEREPFLILSEFTARLSGTLREWWNSVGPDDKNRFLTSQDFTWNIRILYSYFCGDQSQNKEELRRQIFEMKCLSYDRKKIDRHFQRMIKLFYHIGGDISLKQAFISSLPPILSERISALIKERGTSVTQMHVGDIRQTAFYVLDDLCSKRKFFNQMKKMSRDLEKACTKSDLIIKGDKGCSGYCNPSRRRKYKRFKLPSFKERDGRQYRKRRRFFRRSKTSKAMRQKPRSCFTCGKIGHFSRNCPQNKKSIKLISEIQKYTGIDIEDDLESVFSIEDEPSEDTLFSLEFYEEYAGEQYQITSYEAPKTENPPLPKIHTIVEIPQTEVKIYTSKWDKPISVIAFYDTGAAYSIMDPAILPSEYWIPHFRHFGTADDGILTTTVKTKHPITIEFFPGFKYTTKLLGSDIPGKDLLIGFDIYRQLNNKLRIGADGIRWKNQFKRYTEIPRLFQLTTSNELQQLEDVIKNQLCADSHVDFLSKCSHPLWLNQDFFIQLPFKKNENINPTKASHSGMNPEHLQLAIKECDELQQFDLIEPSDSQWACEAFYVNKRSEQVRGKLRLVINYQPLNHFLQDDKFPIPNKLTLFSHLSKAKLFSKFDLKSGFWQLGIHPNERPKTGFCIPDRHFQWKVMPFGLKTAPSLFQKAMIKIFQPILFSALVYIDDILLFSETLEDHIKLLNQFISLVKKFGVMLSAKKMILAQNKIQFLGMDFADGTFSPAGHISLELQKFPDTNLSVKQIQQFLGIVNYIRDFIPEVTEHISPLSDMLKKKPPAWGKCQDNAVKQLKQLAQQVKSLHIPSEGKKILQTDASDQYWSAVLLEEHNGKRKICGFASGKFKVSEQHYHSTFKEILAVKNGIKKFNFFLIHTNFLVEMDMRAFPKMIRLNPKIVPNSQLLRWAQWFSPYQFEVKHLKGKDNILADFLSRPHEFSQRLKNSPKVLMFQRRTRSSSTKSKADSSQSTGSSYKLSHNLPENPPEVFNLDYPWDTSVFLERRTFYELQVFKKYGGSILRPFGVDPEYPFAHIFIPNPTDFSEDLLWMFWYLLNHFHILMKFRCSKFSKIDQVNPWMLKFLLWFNNHNYWASLFKCMKGIKKYVVIWFYRPVNYYQGKLCALPHSSIVKWNHVSVLNDEDEYSELQRFIFQENKCIPKEIWPGSSGSWNYGNSDHPHGQWIRDALREYREMNDYFQDAQDPYPAYSKVDLTQEELNTLRITRSYGSSSEDADMVKRSIYTVQSNIVKDSPRKRKGKAKSRSSTRSEKRRAKNKCKYRSLHGEDWWIELGYSTKPSTPSWTQDSSSEPCV
What is the function of this protein?
Encodes presumably for at least four polypeptides: Movement protein (MP), capsid protein (CP), Protease (PR), and reverse transcriptase (RT).
What are the official names of this protein?
Genome polyprotein.
What is the protein family that this protein belongs to?
Belongs to the Petuviruses genome polyprotein family.
Protein: YBEY_THEP1
Sequence: MIRILGEGKGSNLLEDVKEKLEEIVKKEIGDVHVNVILVSEDEIKELNQQFRSHDQPTDVLTFLLMEEDVYGEIYVCPMIVEENAKEFSNTFEKELLEVVIHGILHLAGYDHEFEDRKSKEMFEKQKKYVEEVWGEWRSDPSEDSGPGKR
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_AERHH
Sequence: MKIRPLHDRVIIKRIEAEAKSAGGIVLTGTAAQKSTRGEVLAVGTGRILDNGDVKALAVKVGDKVIFNEGYGVKTEKLDGQDVLILSETDILAIVEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDK10_HUMAN
Sequence: MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
What is the function of this protein?
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572).  Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2.  Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).
What are the official names of this protein?
Cyclin-dependent kinase 10, Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium basal body.
Protein: BGAL_DIACA
Sequence: MLCGKENNVMKMMLVYVFVLITLISCVYGNVWYDYRAIKINDQRRILLSGSIHYPRSTPEMWPDIIEKAKDSQLDVIQTYVFWNGHEPSEGKYYFEGRYDLVKFIKLIHQAGLFVHLRIGPFACAEWNFGGFPVWLKYVPGIEFRTDNGPFKEKMQVFTTKIVDMMKAEKLFHWQGGPIILNQIENEYGPVEWEIGAPGKAYTHWAAQMAQSLNAGVPWIMCKQDSDVPDNVIDTCNGFYCEGFVPKDKSKPKMWTENWTGWYTEYGKPVPYRPAEDVAFSVARFIQNGGSFMNYYMFHGGTNFETTAGRFVSTSYDYDAPLDEYGLPREPKYTHLKNLHKAIKMCEPALVSSDAKVTNLGSNQEAHVYSSNSGSCAAFLANYDPKWSVKVTFSGMEFELPAWSISILPDCKKEVYNTARVNEPSPKLHSKMTPVISNLNWQSYSDEVPTADSPGTFREKKLYEQINMTWDKSDYLWYMTDVVLDGNEGFLKKGDEPWLTVNSAGHVLHVFVNGQLQGHAYGSLAKPQLTFSQKVKMTAGVNRISLLSAVVGLANVGWHFERYNQGVLGPVTLSGLNEGTRDLTWQYWSYKIGTKGEEQQVYNSGGSSHVQWGPPAWKQPLVWYKTTFDAPGGNDPLALDLGSMGKGQAWINGQSIGRHWSNNIAKGSCNDNCNYAGTYTETKCLSDCGKSSQKWYHVPRSWLQPRGNLLVVFEEWGGDTKWVSLVKRTIA
What are the official names of this protein?
Putative beta-galactosidase, Lactase, SR12 protein.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 35 family.
Protein: RS17_CLOB1
Sequence: MERSNRKTRIGRVVSNKMDKTIVVAVETKVRHPLYGKIMNRTTKFKAHDENNAANINDKVLIMETRPLSKQKRWRLVEVVEKAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: SYP_RICRS
Sequence: MLLSKYFLPVLKEEPSEAQVTSHKLMLRSGMIRQQAAGIYTWLPLGLKVLKNIENIVRLNMNKAGALEVLMPCIQPAHLWMESGRFDNYGKEMLKFQDRHDNTLLFGPTNEDMITDIFRHNIKSYKDLPKNLYHIQWKFRDEIRPRFGVMRGREFLMKDAYSFDINEENAVKTYNQMYKAYINAFRDLGVFAIPVIADNGPIGGNLSHEFHIIAETGESTIYYDKKFKILKDNPDIDVEEIKSWYAAAEEKYEVNKLPISEQEITSSKGIEVGHIFYIGSKYSVNMNALINDEYGKLTPIEMSSYGIGISRLVAAIIEANCDEKGIIWPSSVAPFKVSLINLNIHDSKCVELAEMAYKELSDKNIEVLYDDTEARPGSKFATHDLIGSPHQIIIGPKKAANNIVELKDRKSGVIEDIEVGSLMSVL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_CLOB8
Sequence: MGNVISKVKSLLGFEDYEEYDEYEEEQYEEQVKDEDEIEPVITNKKNSKVVNIHTSSTTKVTITKPIDYEEATEICEALKNRRIVLVNTTVLELKIAQRLLDFISGSCYALGGELQQIEKGVYILSPSNVEVTNELKNELSSKALFNWSK
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: ASTB_BURCH
Sequence: MNAQEANFDGLVGPTHNYAGLSFGNVASLNNEKSAANPKAAAKQGLRKMKQLADLGFAQGVLPPQERPSLRLLRELGFSGKDADVIAKAAKQAPELLAAASSASAMWTANAATVSPSADTSDGRVHFTPANLCSKLHRAIEHEATRRTLSTLFADPTHFAVHEALTGTPALGDEGAANHTRFCAEYGKPGIEFFVYGRAEYRRGPEPKRFPARQTFEASRAVAHRHGLAEEATVYAQQDPDVIDAGVFHNDVISVGNRDTLFTHERAFVNKQAIYDTLTAALDARGARLNVIEVPDAAVSVNDAVTSYLFNSQLLSRADGSQVLVVPQECRENARVAAYLDQLAAGNGPIHDVLVFDLRESMKNGGGPACLRLRVVLNDAERAAVTSNVWINDTLFASLDAWIDKHYRDRLAPEDLADPALLDESRTALDELTQILRVGSLYDFQR
What is the function of this protein?
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
What are the official names of this protein?
N-succinylarginine dihydrolase.
What is the protein family that this protein belongs to?
Belongs to the succinylarginine dihydrolase family.
Protein: SYL_RALSO
Sequence: MQDKYSPSEVEQQAQQHWQAQDAYRVTEHARAADGSDKPKFYACSMLPYPSGKLHMGHVRNYTINDVMMRQLRMKGYNVLMPMGWDAFGMPAENAALNNGVAPAAWTYDNIAYMKKQMQSMGLAIDWSREVATCSPDYYKWNQWLFLKMLEKGIAYRKTGTVNWDPIDQTVLANEQVIDGRGWRSGAVVEKREIPMYYLRITDYAQELLSDLDPLGWPERVKLMQQNWIGKSEGVRFAFPHGIPGDDGKVIGDGKLYVFTTRADTIMGVTFCAVAAEHPIAAHAAQGNPALAAFIDECKHGSVMEADMATMEKKGMPTGLTVTHPLTGEAVPVWVGNYVLMTYGDGAVMGVPAHDERDFAFANKYGLAIKQVIDVKGQPFGTEAWQEWYADKERGVLVHSGKYDGLDYRQAVDAVAADLAAQGLGEKKTTWRLRDWGISRQRYWGTPIPLIHCDSCGVVPVPEQDLPVRLPEDLVPDGSGNPLAKDARFLECTCPSCGKPARRETDTMDTFIDSCWYYMRYTCPDGATMVDGRNDYWMPMDQYIGGIEHAILHLLYARFWTKVMRDLGLVKFDEPFTKLLTQGMVLNETYYREDAAGKKQWINPADVDVQTDDRGRPIGATLKADGQPVVIGGVEKMSKSKNNGIDPQALIDQYGADTARLFTMFAAPPEQQLEWSDAGVEGASRFLRRAWNFGVAHAESIRAGHGNGVVNGATDADRALRRELHTVLKQANYDYERLQYNTVVSAAMKMLNALEGAKDAGADARREGLGILLRVLYPVVPHITHVLWQELGYAGAYGGLLDAPWPQVDEGALVQSEIELVLQVNGKVRGSIVVPADADRAAIEAIAAKDEAVHRFAEGKPPKKIIVVPGRLVNVVA
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR2_METST
Sequence: MKILMVGSGAREHAIAKALNKTADVYTYMGRKNPGLARISKNYTVNDESNFNEIIKFAQENNVELAFIGPEAPLEMGIVDELEKEGIHSVGPTKSAAQIETNKAFMRKLFEDYDIPGSIKYGTFYDLDEAYEFIDNFDEPVVVKPIGLTGGKGVKIVGDQLADNDEAKEYVKEIFHQKMGGFEGVVIEELLLGEEYTIQAFVDGTHLIPMPAAQDHPHAFVGNKGPITGGMGSYSDKNHLLPFLTQEDYDKSVEIMEKTIKAIAKEQEPYKGILYGQFMLCKDGPKVIEYNARFGDPESMNVLSVIDDDLAKISKQIVDGTLDSVNFLNKSSVCKYVVPDKYPNTHVADTVVDVDEDKINELGAQVFYAAVYQDMDDSIKLTSSRALGVLAVKDSIKEAEKICEEAIKYVKGEVYHRNDVATEELLNEKIKHMEEVRL
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: NCAP_RINDR
Sequence: MASLLKSLALFKRAKDKPPLAAGSGGAIRGIKHVIVVPIPGDSSITTRSRLLDRLVKMVGDPDISGPKLTGALISILSLFVESPGQLIQRITDDPDISIKLVEVVQSDKTQSGLTFASRGTSMDDEADRYFTYEEPNDGEERQSYWFENRDIQDIEIQDPEGFNMILATILAQIWILLAKAVTAPDTAAESELRRWVKYTQQRRVIGEFRLDKGWLDTVRNRVAEDLSLRRFMVALILDIKRTPGNKPRIAEMICDIDTYIVEAGLASFILTIKFGIETMYPALGLHEFAGELSTIESLMNLYQQMGELAPYMVILENSIQNKFSAGAYPLLWSYAMGIGVELENSMGGLNFGRSYFDPAYFRLGQEMVRRSAGKVSSNLASELGITEEEARLVSEIAAYTSDDRNNRTSGPKQAQVSFLRTDQGSEAQHSASKKDEARAPQVKKETRTSSKSDKHKEGTDKEPVSSSAMTLIDVDTTLEADTDPLESKKSAEALLRLQAMAGILGDSTLGNDSLRAYNDKDILN
What is the function of this protein?
Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases.  The nucleocapsid (NC) has a helical structure.  The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication.  During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, NP, Protein N.
What is the protein family that this protein belongs to?
Belongs to the paramyxoviruses nucleocapsid family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: SC61B_YARLI
Sequence: MSTSAQVPGGPAAQMKRRNNAQRQEAKASQRPTSTRSVGAGGSSSTMLKLYTDESQGLKVDPVVVMVLSLGFIFSVVALHILAKVSTKLLG
What is the function of this protein?
Necessary for protein translocation in the endoplasmic reticulum.
What are the official names of this protein?
Protein transport protein Sec61 subunit beta.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RUVB_XYLFT
Sequence: MDRIIDSAATREDEAIEVSIRPKRLADYLGQQPVREQMDIYIQATKARAEALDHVLIFGPPGLGKTTLSHVIAYELGVKLRVTSGPVIEKAGDLAALLTNLQPYDVLFIDEIHRLSPVVEEVLYPAMEDFQIDIMIGEGPAARSIKIDLPPFTLIGATTRTGLLTAPLRDRFGIVQRLEFYSPEDLARIVRRSAGILNIDCTTEGAAEIAQRARGTPRIANRLLRRVRDYAEVKADGQITIEVAQAAMQMLKVDQGGFDELDRRLLHTIVEYFDGGPVGIESLAASLSEERGTLEDVVEPYLIQQGFLVRTARGRMATDKAYQHLALQPRERVSAFTDPEDLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NADE_MYCTO
Sequence: MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAVFPELTLSGYSIEDVLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLRHRHRIYNTAVVIHRGAVLGVVPKSYLPTYREFYERRQMAPGDGERGTIRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMFVPMPPSAEAALAGATVLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTTDLAWDGQTMIWENGALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNRRHHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEAYNIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRSDILAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPYSVGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTYGVGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEITPELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAWNDAERGNWPPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNGPKVSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses L-glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine-dependent NAD(+) synthetase, NAD(+) synthase [glutamine-hydrolyzing].
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD synthetase family.
Protein: SODC_HALRO
Sequence: MSIKAVCVLVGSVKGTLNFKQDAIGSCTVTGEVSGLIPGKHGFHIHEYGDLTNGCTSSGGHFNPFKQIHGAPEDDIRHVGDLGNITADSSGVATVNITDRMISLTGEHSIIGRAVVVHAGEDDLGKGGHEDSKTTGHAGGRLSCGVIGINHL
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.  The plasma superoxide dismutase has phagocytosis-stimulating activity and may play an important role in the biological defenses of the organism.
What are the official names of this protein?
Superoxide dismutase [Cu-Zn].
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_RHOPS
Sequence: MSYFKTAMLLAGLTALFMGIGYLIGGASGALIALVVAAAMNVFTYWNSDRMVLSMYGAQEVDVRSAPDLVRMVAELAGRAGLPMPRVFIMDNPQPNAFATGRNPENAAVAVTTGLMQQLSREELAGVIAHELAHVKNHDTLLMTITATIAGAISMVAQFGMFFGGNRENNNGPGLIGSLALMILAPLGAMLVQMAISRTREYAADEMGARICGQPMWLASALGRIDAAAHQVPNVEAERAPATAHMFIINPLSGQGMDNLFATHPSTQNRIAALQRLTGEIGGGGASIGRPAGPSPRGAPRSPWSGQPRARGPWG
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRB7_RAT
Sequence: MELDLSPSHLSSSPEDVCPTPGTPPETPPPPDNPPPGDVKRSQPLPIPSSRKLREEEFQATSLPSIPNPFPELCSPPSQKPILGGSSGARGLLPRDSSRLCVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDENWGLVECHPYLALERGLEDHESVVEVQEAWPVGGDSRFIFRKNFAKYELFKSPPHTLFPEKMVSSCLDTPTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADINESNVYVVTQGRKLYGIPTDFGFCVKPNKLRNGHKGLHIFCSEDEQSRTCWLSAFRLFKYGVQLYKNYQQAQSRHLRLSYLGSPPLRSVSDNTLVAMDFSGHAGRVIENPQEALSAATEEAQAWRKKTNHRLSLPTPCSGLSLSAAIHRTQPWFHGRISREESQRLIGQQGLVDGVFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEDEGCLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCARVAL
What is the function of this protein?
Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling.  Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3.  Promotes activation of HRAS.  Plays a role in signal transduction in response to EGF.  Plays a role in the regulation of cell proliferation and cell migration.  Plays a role in the assembly and stability of RNA stress granules.  Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated.  Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).
What are the official names of this protein?
Growth factor receptor-bound protein 7, Epidermal growth factor receptor GRB-7, GRB7 adapter protein.
What is the protein family that this protein belongs to?
Belongs to the GRB7/10/14 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule. Note=Predominantly cytoplasmic. Detected in stress granules where mRNA is stored under stress conditions.
Protein: RS6_STACT
Sequence: MRTYEIMYVVRPNIEDEARKALVERFNGILTNDGAEIIEEKDWGKRRLAYEIEDFKEGYYYIVRINTENSEATDEFQRLAKINDDIIRYIVIREDEDK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PROCG_OLEEU
Sequence: MSWQAYVYEHLMCEIESHHLSSAAILGHDGTVWAQSTAFPQFKPEEITGIMKDFDEPGHLAPTGMFVAGAKYMVIQGEPGAVIRGKKGAGGITIKKTGQALVVGIYDEPMTPGQCNMVVERLGDYLLEQGQ
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-3, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: IDI_NOCFA
Sequence: MPVELVDEAGRAVGACPVAEAHRDPGKLHRAFSVLLFDTAGRVLLQQRAAVKTRFPLLWANTCCGHPAPGESVEAAAATRLAEELGVAAGLTEVGVFRYRAADTATGRVEHEWDHVLIGTLDTTPHPDPAEVANLRWVRPAEVRAKLAAEPAAYTPWLAEVLEIADAAYRESAGR
What is the function of this protein?
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate Delta-isomerase, IPP isomerase, IPP:DMAPP isomerase, Isopentenyl pyrophosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATP14_PICAN
Sequence: NLVTDLYVKELKAFKPTPASAADAEAATKPWKLPQAAKVPSLEGEGADALAEYDSAKVEVVEASGETAAEEYNPDDWFVFEEEEEPGHH
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:25759169).  F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:27791192).  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).  Part of the peripheral stalk (PubMed:27791192).
What are the official names of this protein?
ATP synthase subunit H, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase h subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=The F-type ATP synthase complex is anchored in the mitochondrial inner membrane via the F(0) domain with the F(1) domain and the peripheral stalk extending into the mitochondrial matrix.