PharMolix/UniProtQA huggingface dataset:
Protein: NDK_XANOM
Sequence: MALERTLSIIKPDAVAKNVIGEIYSRFEKAGLKVVAAKYKQLSRREAEGFYAVHRERPFFNALVEFMISGPVMIQALEGENAVAAHRDLLGATNPKDAAPGTIRADFADSIDANAAHGSDSVENAANEVAYFFAATEVVSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIAS1_MOUSE
Sequence: MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPPTLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRTYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGSWAPMRSKKEVQEVTASYNGVDGCLSSTLEHQVASHNQSSNKNKKVEVIDLTIDSSSDEEEEEPPAKRTCPSLSPTSPLSNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTSLPATNGSSSGSNSSLVSSNSLRESHGHGVASRSSADTASIFGIIPDIISLD
What is the function of this protein?
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.  Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.  In vitro, binds A/T-rich DNA (By similarity).  The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.  Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation.  PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation.  Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.  Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474).
What are the official names of this protein?
E3 SUMO-protein ligase PIAS1, DEAD/H box-binding protein 1, Protein inhibitor of activated STAT protein 1, RING-type E3 ubiquitin transferase PIAS1.
What is the protein family that this protein belongs to?
Belongs to the PIAS family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, PML body. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.
Protein: U5S1_PONAB
Sequence: MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDIGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLPKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLELAKQDVVLNYPM
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity).  Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).
What are the official names of this protein?
116 kDa U5 small nuclear ribonucleoprotein component, Elongation factor Tu GTP-binding domain protein 2, U5 snRNP-specific protein, 116 kDa, U5-116 kDa.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSB1_PYRAE
Sequence: MTTTVGIAVKDGVVLATDKRVTAGYYIAHKRGEKIWKIDDHVAATMSGGVADLQSVLSFLTLRAHEYKIEYKRPIPISALVNYMSLILFYSRPYIYIVHSIIGGVDEEEGAVLYMVDWLGTVTKEKYIATGSGSPYAKGALEVGYREDMTLEDAVDLAIKAVKAAIRNDPGSGEGIDVVVITRKEGFKRVFTTQQKLVLPSL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 1, 20S proteasome beta subunit 1, Proteasome core protein PsmB 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTDC_MOUSE
Sequence: MASVSLLSALAVRLLRPTHGCHPRLQPFHLAAVRNEAVVISGRKLAQQIKQEVQQEVEEWVASGNKRPHLSVILVGDNPASHSYVLNKTRAAAEVGINSETIVKPASVSEEELLNSIRKLNNDENVDGLLVQLPLPEHIDERKVCNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVQDPVTAKPKLVGDVDFEGVKKKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRPEELEVFKSKQRGVATN
What is the function of this protein?
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.
What are the official names of this protein?
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: URK_STRTD
Sequence: MPKKPIIIGVTGGSGGGKTSVSRAILSNFPDEKIAMIEHDSYYKDQSHLTFEERVSTNYDHPFAFDTDLMIEHINELIAGRPVDIPIYDYTQHTRSNKTYRQEPQDVFIVEGILVLEDKRLRDLMDIKLFVDTDDDIRIIRRIKRDMEERGRSLDSIIDQYNSVVKPMYHQFIEPTKRYADVVIPEGVSNTVAIDLINTKVASILEESKKA
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAPB_ACTP2
Sequence: MSLPILDQLEEKIKQAVETIQLLQLEVEELKEKNTTVEQEKETLRQEYEQLKSEQQSFQDRLRSLLGQIDNV
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: SYL_MACCJ
Sequence: MSFNHQTIEKKWQKYWLDNHTFKTTEDKDKNFYALDMFPYPSGAGLHVGHPEGYTATDIISRFKRMQGYNVLHPMGWDAFGLPAEQYAIDTGNDPAEFTEKNIATFKRQIQELGFSYDWEREINTTDPEYYKWTQWIFIQLYKKGLAYVDEVAVNWCPALGTVLSNEEVIDGVSERGGHPVIRKPMRQWVLKITEYADRLLEDLEELDWPESLKDMQRNWIGRSEGAEVAFEVENLDHSFKVFTTRPDTIYGATYAVLSPEHELVAAITSEEQAEAVKAYQEQAARKSDLERTDLAKDKTGVFTGSYAINPFNGERMPIWISDYVLASYGTGAIMAVPAHDERDFEFAKQFGLDIKPVIEGGDNTSAYTGDGAHINSGELDGLNKEEGIRRAIELLEAKGIGEKKVSYKLRDWLFSRQRYWGEPIPVITWEDGSMTTVPEEELPLMLPKTEHIKPSGTGESPLANIDEFVNVTDPVTGMKGRRETNTMPQWAGSCWYYLRYIDPKNSDMIADPELLKKWLPVDLYIGGAEHAVLHLLYARFWHKVLYDLGVVHTKEPFQKLFNQGMILGEGNEKMSKSKGNVVNPDDVVASHGADTLRLYEMFMGPLDASIAWSTNGLDGARRFLDRVYRLLVNEDGTLSEKITEQPVGSMEKVYHQTVKKVTDDYETLGFNTAISQMMVFINEGYKSEQLNIDHIRGFVKLLNPIAPHITEELWEKLGGTESITYEAWPVYDESKLVDSEVEIVIQVNGKLKQKATIAKDMDKSEMETFALSLEAVQTAIEGKTVRKVIAVPNKLVNIVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS9_ENCCU
Sequence: MAGKKGSKRASTPRDPFEKERLIREAQLVGVYGLKNKHELWVMEKIFAKDKERARILLTSTNPEDIPINGRSLLRRLMKYGILGGIDLCDKQEVVNGLNKVLDLTINHYLERRLQFRVFAAGLAKSVHHARLLIGGRCISIKDQIVDVPGFMVRADKEPLIEYNPYSRYGDKGKKKAEAKVGEE
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
What are the official names of this protein?
40S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.
Protein: MREB_SALTI
Sequence: MLKKFRGMFSNDLSIDLGTANTLIYVKGQGIVLNEPSVVAIRQDRAGSPKSVAAVGHDAKQMLGRTPGNIAAIRPMKDGVIADFFVTEKMLQHFIKQVHSNSFMRPSPRVLVCVPVGATQVERRAIRESAQGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDEVREIEVRGRNLAEGVPRGFTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISERGMVLTGGGALLRNLDRLLMEETGIPVVVAEDPLTCVARGGGKALEMIDMHGGDLFSEE
What is the function of this protein?
Forms membrane-associated dynamic filaments that are essential for cell shape determination.  Acts by regulating cell wall synthesis and cell elongation, and thus cell shape.  A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
What are the official names of this protein?
Cell shape-determining protein MreB.
What is the protein family that this protein belongs to?
Belongs to the FtsA/MreB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Membrane-associated.
Protein: FPG_STRPM
Sequence: MPELPEVETVRRGLETLVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYLLFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFEAALLSSQKPIKPHLLDQTLVAGLGNIYVDEVLWAAKVHPGTASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVYGQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRP
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: ENO_AMOA5
Sequence: MSIIKSVYARQILDSRGNPTIEVDVCTEQGFVGRAAVPSGASTGLHEAMELRDKDSAVYLGKGVQKAIKHVKEIIAPVLIGRSVFNQQAIDTLLIELDGTLNKARLGANAILGTSIAVAKAAAMSLNIPLYQYIGGLNAYILPTPMINIFNGGAHADNNVDIQEFMVMPIKANSFAEALRMGVEVFHQLGRILKEKGLSTNVGDEGGYASNLPSNEAAMEFILQAIEKAGYQPGEDISIALDAASTEFYQAEKEVYHFKKSTGIKLTSTELVDFWKNWVQKYPIISIEDGMAEDDWEGWHQLTQAIGSKVQLVGDDLFVTNTKRLAKGIEQNIANAVLIKMNQVGTLSETLDTVNLAKKHGYQNIISHRSGETEDSTIADLAVALNAGQIKTGSVSRTDRTAKYNQLLRIEETLGEHARFAGHPFKK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: CH10_STRP4
Sequence: MLKPXGDRVVLKIEEKEQTVGGFVLAGSAQEKTKTAQVVATGQGVRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICE1_ARATH
Sequence: MGLDGNNGGGVWLNGGGGEREENEEGSWGRNQEDGSSQFKPMLEGDWFSSNQPHPQDLQMLQNQPDFRYFGGFPFNPNDNLLLQHSIDSSSSCSPSQAFSLDPSQQNQFLSTNNNKGCLLNVPSSANPFDNAFEFGSESGFLNQIHAPISMGFGSLTQLGNRDLSSVPDFLSARSLLAPESNNNNTMLCGGFTAPLELEGFGSPANGGFVGNRAKVLKPLEVLASSGAQPTLFQKRAAMRQSSGSKMGNSESSGMRRFSDDGDMDETGIEVSGLNYESDEINESGKAAESVQIGGGGKGKKKGMPAKNLMAERRRRKKLNDRLYMLRSVVPKISKMDRASILGDAIDYLKELLQRINDLHNELESTPPGSLPPTSSSFHPLTPTPQTLSCRVKEELCPSSLPSPKGQQARVEVRLREGRAVNIHMFCGRRPGLLLATMKALDNLGLDVQQAVISCFNGFALDVFRAEQCQEGQEILPDQIKAVLFDTAGYAGMI
What is the function of this protein?
Transcriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes.  Binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter.  Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA.  Functions as a dimer with SPCH during stomatal initiation (PubMed:18641265, PubMed:28507175).
What are the official names of this protein?
Transcription factor ICE1, Basic helix-loop-helix protein 116, AtbHLH116, bHLH 116, Inducer of CBF expression 1, Transcription factor EN 45, Transcription factor SCREAM, bHLH transcription factor bHLH116.
What are the subcellular locations of this protein?
Nucleus.
Protein: AB1G_ARATH
Sequence: MARIVAANDDDSMELNTISSIHDSTLGQLLKNVSDVRKMAIGDETPVHESLNQDYNDGYMRTVPFVLSFDNLTYNVSVRPKLDFRNLFPRRRTEDPEIAQTARPKTKTLLNNISGETRDGEIMAVLGASGSGKSTLIDALANRIAKGSLKGTVKLNGETLQSRMLKVISAYVMQDDLLFPMLTVEETLMFAAEFRLPRSLPKSKKKLRVQALIDQLGIRNAAKTIIGDEGHRGISGGERRRVSIGIDIIHDPILLFLDEPTSGLDSTSAFMVVKVLKRIAQSGSIVIMSIHQPSHRVLGLLDRLIFLSRGHTVYSGSPASLPRFFTEFGSPIPENENRTEFALDLIRELEGSAGGTRGLIEFNKKWQEMKKQSNRQPPLTPPSSPYPNLTLKEAIAASISRGKLVSGGESVAHGGATTNTTTLAVPAFANPMWIEIKTLSKRSMLNSRRQPELFGIRIASVVITGFILATVFWRLDNSPKGVQERLGFFAFAMSTMFYTCADALPVFLQERYIFMRETAYNAYRRSSYVLSHAIVSFPSLIFLSVAFAATTYWAVGLDGGLTGLLFYCLIILASFWSGSSFVTFLSGVVPSVMLGYTIVVAILAYFLLFSGFFINRNRIPDYWIWFHYMSLVKYPYEAVLQNEFSDATKCFVRGVQIFDNTPLGELPEVMKLKLLGTVSKSLGVTISSTTCLTTGSDILRQQGVVQLSKWNCLFITVAFGFFFRILFYFTLLLGSKNKRR
What are the official names of this protein?
ABC transporter G family member 1, ABC transporter ABCG.1, AtABCG1, White-brown complex homolog protein 1, AtWBC1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HIS1_BUCSC
Sequence: MIHNNRLRIVMQKNWKLSNDSKDLLARCGIKINLYKKKLIAFSENMPIVYICVRDDDIPGLIMDGIVDVGIIGENVLEEEVLSRKLRSDNIDYIKLKRLDFGTCRLSLAIPLDKTYKDISCLNNSRIATSYPHLLKKYFDKNNITFKSCMLNGSVEVAPRAGLSDAICDLVSTGATLEANGLREVQVIFRSKACLICKVGDISSEKRNVLNTLLTRIQGVIKARESKYIMLHAPIKRLEEVVQLLHGAERPTILKLAGDNTRVAMHMVSSETLFWETMENLKLLGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR6_NEOYE
Sequence: MLTAENIQLNCYETVYILKSDLNEDKTLSIINDYKSMLTNGGAKNIVLQHRGRRHLSYTINDYHDGIYVQVNYEGNGQLVKSFEKSLRFDDNIIRYLTNKQKRNIKKDS
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PETN_FAGEA
Sequence: MDIVSLAWAALMVVFTFSLSLVVWGRSGL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 8, Cytochrome b6-f complex subunit PetN, Cytochrome b6-f complex subunit VIII.
What is the protein family that this protein belongs to?
Belongs to the PetN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: HRCU_RALSO
Sequence: MSDEKTEQPTDKKLEDAHRDGETAKSADLTAAAVLLSGCLLLALTASVFGERWRALLDLALDVDSSRHPLMTLKQTISHFALQLVLMTLPVGFVFALVAWIATWAQTGVVLSFKPVELKMSAINPASGLKRIFSVRSMIDLVKMIIKGVAVAAAVWKLILILMPSIVGAAYQSVMDIAEIGMTLLVRLLAAGGGLFLILGAADFGIQRWLFIRDHRMSKDEVKREHKNSEGDPHIKGERKKLARELADEAKPKQSVAGAQAVVVNPTHYAVAIRYAPEEYGLPRIIAKGVDDEALALREEAAALGIPIVGNPPLARSLYRVDLYGPVPEPLFETVAEVLAWVGEMGASGTPGAEPQH
What is the function of this protein?
Involved in the secretion of PopA, a proteinaceous elicitor of the hypersensitivity response in plants.
What are the official names of this protein?
Hypersensitivity response secretion protein HrcU.
What is the protein family that this protein belongs to?
Belongs to the type III secretion exporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBID_YERPN
Sequence: MISMKYRDLRDFLSLLEQRGELKRISQPIDPYLEMTEIADRTLRAGGPALLFENPKGYSMPVLCNLFGTAKRVAMGMGQEDVSALRDVGKLLAFLKEPDPPKGFRDLFDKLPKFKQVLNMPTKRLNSAPCQEQVWQGEDVDLSRIPVMHCWPEDAAPLVSWGLTITRGPHKERQNLGIYRQQVLGKNKLIMRWLSHRGGALDYQEWCEAHPGERFPVAVALGADPATILAAVTPVPDTLSEYAFAGLLRGHKTEVVKCLSNDLEVPASAEIVLEGYIEQGDMAPEGPYGDHTGYYNEIDNFPVFTVTHITQRQDAIYHSTYTGRPPDEPAVMGVALNEVFVPILQKQFPEIVDFYLPPEGCSYRLAVVTIKKQYAGHAKRVMMGIWSFLRQFMYTKFVIVCDDDINARDWNDVIWAITTRMDPSRDTVLIENTPIDYLDFASPVSGLGSKMGLDATNKWPAETPREWGRPIKMDEDVRARIDALWDELAIFSDKDAKR
What is the function of this protein?
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
What are the official names of this protein?
3-octaprenyl-4-hydroxybenzoate carboxy-lyase, Polyprenyl p-hydroxybenzoate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiD family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: COBT_DESRM
Sequence: MTLLAETLSKIQAPDQTCVEQAKQRLDSLTKPPGSLGILEDIAWRLAGIQRVPLPQLPREKVSLVLAGDHGVVAEGVSAFPQEVTPQMIFNFLQGGAGINVLARQAGAKVVVADIGVAGPPLEKTGLVSCRVKSGTDNFAVGPAMSREEAVKSIEAGISLLQQQVKERPALVAIGEMGIGNTTPSAAILAAFTGMPVEEITGRGTGIDNQRLQHKIAVIKRGLEVNRPDANDGLDVLSKVGGLEIGGMAGIILGCAAEGIPVVLDGFISGAAALVAQSLAPLSREYMFASHGSVEPGHRIMLEKLGLKPMLQMEMRLGEGTGAALAYPIIESAVRIINEMATFAEAGVSKG
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: TAT_HV1B9
Sequence: MEPVNPSLEPWKHPGSQPKTACTNCYCKKCCFHCQACFITKGLGISYGRKKRRQRRRPPQDSQTHQVSLSKPSSQPRGDPTGPKEQKKKVERETETDPVH
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: COTY_BACSU
Sequence: MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPTIAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPVDVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHHNG
What are the official names of this protein?
Spore coat protein Y.
What is the protein family that this protein belongs to?
To B.subtilis CotZ.
What are the subcellular locations of this protein?
Spore coat. Note=Outer coat.
Protein: CP124_MYCTO
Sequence: MGLNTAIATRVNGTPPPEVPIAGIELGSLDFWALDDDVRDGAFATLRREAPISFWPTIELPGFVAGNGHWALTKNDDVFYASRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS
What is the function of this protein?
Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate.  Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4-en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate.  Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.
What are the official names of this protein?
Methyl-branched lipid omega-hydroxylase, Cholest-4-en-3-one C26-monooxygenase, Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming], Cholesterol C26-monooxygenase, Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming], Cytochrome P450 124, Steroid C26-monooxygenase, Steroid C27-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.