PharMolix/UniProtQA huggingface dataset:
Protein: Y6450_RHOOB
Sequence: MGMRPPAGLPSLSKRSRVLLVLALVVAALLLVGPRLISTYTDWLWFGEVGFRGVFTTVLVTRLLLFLVVGVVVGGIVWLALLLAYRSRPVFVPVSGPNDPVARYRTTVMTRLRLFGLAIPIAVGLLAGLIAQSSWVTVQLFVNGGSFGVADPEFGLDVGFYTFDLPFYRFVLNWLFVAVLLAFFASLVTHYIFGGLKLAGRGGALTNAARVQLAVLAGTFILLKAVAYWFDRYSLLSSSRKEPTFTGGSYTDMNAVLQAKLILLAIAVICAGAFFAAIFLRDLRIPAMATALLVLSSILVGAVWPLVVEQFSVRPNAADKESAYIERNIAATRQAYGITDDKVEYQDYQGYGTTPPRDVPADVTTIANTRLLDPNILSRTFTQQQQLKNFYGFPPTLDIDRYDIDGEMRDYIVAARELSSKSLTGNQTDWINKHTVYTHGNGLVAAPANRVNAAAGESAEEAANSNSGYPVYMVSDIASQAAGDQVIPVEQPRIYYGEVIADTDADYAIVGGSEGSDPREYDTDTSRYTYTGSGGVPIGNWFNRLAFAAKYTERNILFSGAIGSDSKIIYNRDPRDRVTHVAPWLTADGDSYPAVVDGKVVWIVDAYTTLQDYPYAQRSSLDGLVEDSIDQNTGRLLPRKEVSYIRNSVKATVDAYDGTVKLYQVDQNDPVLDAWMGVFPDAVQPADSIPDELRAHFRYPEDLFKVQREMLAKYHVDDPKEFFTNNAFWSVPSDPTIDTSANQPPYYVLVGDPETGKPSFNLTSAMVGYSREFLSAYLSVKSDPENYGKFTVLQLPTDTQTQGPQQTQNSMISDPRVASERTLLERSNKIQYGNLLTLPIANGGILYVEPMYTERSSTGPNTSTFPQLSRVLVSYREPPPSNSVRVGYAPTLAQALDQVFGAGTGSVATAPSAEEGTPPETGTTPPVEQGAAPPAPTAPATPPSGTDVSAAVAELDASLDALTAAQRSGDFAAYGAALARVQKAVAAYEAIPK
What are the official names of this protein?
UPF0182 protein ROP_64500.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TILS_LEPBJ
Sequence: MRDKISESTRNIFDTVWKRIFPFHEMILSRPAVLSYSGGKDSSLLLHFYFWLWAEKKIPVPCIYHLDHSIRFNLEQEKKILDYTESTFPFPNLFKKKNIPALSQKLGKTLEETGRAFRYKDLEKISNQYEGYIVTGHHSTDYLETVFLNLIRGGGWNSLRTLGWYEKNRFRPLFAFTEDEIKTISQSESWPIFEDESNQSNEYLRNRIRNYILPLLLQEGADPDRIYKNFHRMEKPTSKILLKEVSSHKTPSFLKIDVWVLNDLSERERKFFIDRYLRSLNLHPTTRNFFQDLMDCLKKMNSFGIENKEAWFWKSSSYDLYVIPKNSLCLKKFKLESKNMILKWNGSQKKISPGFIPGLCSPGAKIRKNGMSIEISEILRQKEIPVPVRKMLPILYREGKVDVICLSLWDPRLGDIVADRSRNFI
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_PROMT
Sequence: MSRTGKKPISLPEKVDVKFEGLSITVKGPKGELKRTLPNGVSLSKDENFIFVKPINEKRQSREMHGLCRSLVANMVEGVSNGFTKKLEIVGVGSRAQVKGKTLVVSAGYSHPVEVVPPEGITFKVENNTNVIVTGPDKELVGNEAAKIRAIRPPEPYKGKGIKYQGELIIRKAGKSGKT
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: Y807_MALP2
Sequence: MNMQKMLQQAKALQSKMEKKIKEFEQEEFEFVYQKSITIQIKGNYEIIKMDINKELIDPEDKTMLEEMISEAINEAISAITEEKEKITKGAMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein MYPE8070.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: CIDB_STAAN
Sequence: MNDYVQALLMILLTVVLYYFAKRLQQKYPNPFLNPALIASLGIIFVLLIFGISYNGYMKGGSWINHILNATVVCLAYPLYKNREKIKDNVSIIFASVLTGVMLNFMLVFLTLKAFGYSKDVIVTLLPRSITAAVGIEVSHELGGTDTMTVLFIITTGLIGSILGSMLLRFGRFESSIAKGLTYGNASHAFGTAKALEMDIESGAFSSIGMILTAVISSVLIPVLILLFY
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
What are the official names of this protein?
Holin-like protein CidB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. CidB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PEPT_ECODH
Sequence: MDKLLERFLNYVSLDTQSKAGVRQVPSTEGQWKLLHLLKEQLEEMGLINVTLSEKGTLMATLPANVPGDIPAIGFISHVDTSPDCSGKNVNPQIVENYRGGDIALGIGDEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGIAEIMTALAVLQQKKIPHGDIRVAFTPDEEVGKGAKHFDVDAFDARWAYTVDGGGVGELEFENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADESPEMTEGYEGFYHLASMKGTVERADMHYIIRDFDRKQFEARKRKMMEIAKKVGKGLHPDCYIELVIEDSYYNMREKVVEHPHILDIAQQAMRDCDIEPELKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAELTAQRK
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U1165_ARATH
Sequence: MAAHATSEPAVNLPATQFESQVTEPFGVTLLVRHLPDGIPHDIVSRLFSQYGASAVRPCSGGKLRNAAFVDFKNEAFASQAHRQLNGLRFLGKVLQVQRANKPNDNKKSRQIEESVTKGNAFSTVSTNNDSKSGQILSGEPIAPKLGIDYPFPPHLQYAYPPPDANILANITNALIAVPPLYTQVLHLMNKMNLPPPFRLALPTPPLPKAGPQQTDLEHQSSSESEMESDEDIGTSKSGRKRARHGFLVGLGMDKDVPHETVGVKPSSLTPKEIPRIRKNKHVMQIKITSKVTQDEYKEESENEDPADEPKEKDSNLKPFASLEELEKGRLPPQDILSLPMFKNYTAGNPSVVLYIKNLAKDVVIDDFYYIFGSQFESSEVAKSSLGVRLMQEGRMRGQAFLTFPSVEVAHRALNLVNGFVFKGKPMIIQFGRTPGAAKPNE
What is the function of this protein?
Component of minor spliceosome required for U12-type intron splicing and alternative splicing of many introns.  Binds specifically to U12 snRNA, which is necessary for branch-point site recognition.  Required for normal plant development.
What are the official names of this protein?
U11/U12 small nuclear ribonucleoprotein 65 kDa protein, U11/U12 snRNP 65 kDa protein, U11/U12-65K.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBS1_FLAPR
Sequence: MASIPATVATVAQANMVAPFTGLKANAAFPVTKKVNDFSTLPSNGGRVQCMKVWPPLGKKKYETLSYLPDLTEVQLAKEVDYLLRNKWVPCLEFELEHGFVYRENARSPGYYDGRYWTMWKLPMFGCTDSAQVMKELQECKKEYPQAWIRIIGFDNVRQVQCISFIASKPGGF
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.  Although the small subunit is not catalytic it is essential for maximal activity.
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic 1, RuBisCO small subunit 1.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CH60_GEODF
Sequence: MAKVIKFDQEGRNAFLKGVNTLADAVKVTLGPKGRNVVIEKSFGAPLITKDGVTVAKEIELEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGAKLVAAGHNPMEIKRGIDKAVETLVAELKSISKPIKDHKEIAQVGTISANNDKTIGDIIAEAMEKVGKEGVITVEEAKAMETSLETVEGMQFDRGYLSPYFVTDPERMEANLENANILIHDKKISNMKDLLPVLEQTAKSGRPLVIIAEDIEGEALATLVVNKLRGVLNICAVKAPGFGDRRKAMLEDIAVLTGGKVISEEVGFKLENTTMDMLGQAKKITIDKDNTTIIDGAGAEGDIAGRVKMIRAQIEETSSDYDREKLQERLAKLVGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVDEGIVPGGGVAYLRAMSTLDALNLPTEQQFGVNVIKRALEEPIRQIAQNAGVDGSIVVDKVKNGKDAFGYNAADDEYVDMIQAGIIDPTKVSRSALQNASSIAGLMLTTEAMIADKPKEEGAMPAMPGGMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_BUCAI
Sequence: MQNQRIRIRLKAFDHRLIDQSTTEIVETAKRTGAQVRGPIPLPTRKERFTILVSPHVNKDARDQYEIRTHKRLIDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: GPMI_UREU1
Sequence: MSLNKKLALIIIDGLGIGKKDDTNAVYLANPKTLNYLIKNYPTLEISAAQQPIGLLENQAGNSEIGHLTIGAGRIILNDNANINSYTKRLDYESLVLNDINNEIVHVVGMYSNGLVHSNYEHIHWIIKELVKNNNQVVLHLISDGRDDYPYGFAQFIEQINALKTQYNVIIKSLSGRYFAMDRDQRWERTQKAFNTMFIKQDKICEQSLLEVAQSIANHYESDEFVEPIVFNNDEKYNLKPYQKVILTNYRSDRMRQLAHLLKPNRKFNYHNPFLIKDIHLITLVPFPDVDAITLFEKQNLNNTLGDVLNDHHIKQARVAETEKYGHISFFFDGGINKHYASKTQYLIPSQKVATYDLCPQMSASLITKTIIDHYFDHDVFIVNYANPDMVGHSGNMKQTIQAILSVDSEIQKLYDFFKKNNGVLMITGDHGNAETMIDANGQIITSHSINDVWFIITDNNIVFDQTQKFSLANIAPTILEYLNIKKPIEMAASSMIKKIHK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: CCR35_ARATH
Sequence: MGYLSCKAGSAVAIAVSSAASTSGSTSSKASAPPESPIEDRPRLRRFLHRDLESATGGFDINNLLGRGSHGSVYKAVIGSRHIAVKRPSKSREISREFHNEFEILSRIRSPRFVNLLGFSADNSKEPLLVVEFMGNGSLYDVIHSDTVLNSGAISSWSKRIKIALQIAKAVHLLHSQETPIIHRDIKSANVLMDKNLNAKLGDFGLAIRCNVDDQKVKSTPPAGTMGYLDPDYVTADRLSTKTDVFSFGILLLEIISGRKAIDVRYSPSFIVDWAIPMIKRGKIGGIYDPRIGPPIDVSVRNHLGLVAAKCVRTCREKRPGMEEVVGWLTGLTKSVRSRRWDELSIGNPCMMVETVGGRPVE
What are the official names of this protein?
Serine/threonine-protein kinase-like protein At3g51990, CRINKLY 4-related kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: GCH1_HELPY
Sequence: MENFFNQFFESIGEDKNREGLKETPKRVQELWKFLYKGYKEDPRVALKSAYFQGVCDEMIVAQNIEFYSTCEHHLLPFLGNISVGYIPKEKIVGISAIAKLIEIYSRRLQIQERLTIQIAETFDEIIEPRGVIVVCEAKHLCMSMQGVQKQNAIIKTSVLRGLFKKDSKTRAEFMQLLKS
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: NUOE_PSEAE
Sequence: MSQSNLIQTDRFVLSETERSSIEHEMHHYEDPRAASIEALKIVQKQRGWVPDGAIPAIGEVLGIPASDVEGVATFYSQIFRQPVGRHIIRVCDSMVCYIGGHESVVGEIQKQLGIGLGQTTADGRFTLLPVCCLGNCDKAPALMIDDDTHGDVRPDGVAKLLEAYV
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit E, NADH dehydrogenase I subunit E, NDH-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the complex I 24 kDa subunit family.
Protein: CK2_ARATH
Sequence: MTMGGTEKNVENKQYRLPREVKEALQAIASEWEDVIDSKALQVIPLKGAMTNEVFQIKWPTREKGPSRKVLVRIYGEGVEIFFDREDEIRTFEFMSKHGHGPLLLGRFGNGRIEEFLHARTLSACDLRDPEISGRIATRMKEFHGLEMPGAKKALLWDRLRNWLTACKRLASPEEAKSFRLDVMEMEINMLEKSLFDNDENIGFCHNDLQYGNIMMDEETKAITIIDYEYSCYNPVAYDIANHFCEMAADYHTETPHIMDYSKYPGVEERQRFLKTYMSYSDEKPSDTMVKKLLEDVEKYTLASHLIWGLWGIISEHVNEIDFDYMEYARQRFEQYWLTKPRLLAASEHK
What is the function of this protein?
Involved in phospholipid biosynthesis.  Catalyzes the first step in phosphatidylcholine biosynthesis (By similarity).
What are the official names of this protein?
Probable choline kinase 2.
What is the protein family that this protein belongs to?
Belongs to the choline/ethanolamine kinase family.
Protein: MAOX_HUMAN
Sequence: MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ
What is the function of this protein?
Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate.
What are the official names of this protein?
NADP-dependent malic enzyme, NADP-ME, Malic enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the malic enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2B_XENLA
Sequence: MVSRRKAPRSGQSEQWVLLAPESLSGDAKNLSDETVFVKLRAPFADKGAMFLFINSGQQICEVKAFHEEYRSWFIGQTVQQDGRLLIATPIDPLFLVLPYLIKADKEQGKFQPVEQIVVDEEFPSCGMLLQCTPVAKSLHHVTEEKEIGSKKFHKYSKEKALVWLKKKVDQTVKVLKSSKVCVGGGVQSATFIRSTQGSDVKEEDYTRYAHGLISEYLTEDLREDLSKYLGLPDLSSPTPEPPVKKRRVSDAPVEADEDYTKYNSDNKSRKSNSKMTAAQKSLAKVDKSGMKNISAFFSPKAKAAK
What is the function of this protein?
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids.  Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication.  Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).
What are the official names of this protein?
Ribonuclease H2 subunit B, RNase H2 subunit B, Ribonuclease HI subunit B.
What is the protein family that this protein belongs to?
Belongs to the RNase H2 subunit B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYSJ_NEIMF
Sequence: MSEHDMQNTNPPLPPLPPEITQLLSGLDAAQWAWLSGYAWAKAGNGASAGLPALQTALPAAEPFSVTVLSASQTGNAKSVADKASDSLEAAGIQVRRAELKDYKAKNIADERRLLLVTSTQGEGEPPEEAVVLHKLLNGKKAPKLDKLQFAVLGLGDSSYPNFCRAGKDFDRRFEELGAKRLLERVDADLDFAAAADGWTGRIVARLKEEAAKNRATPAPQTTPPAGLQTAPDGRYCKADPFPAALLANQKITARQSDKDVRHIEIDLSGSDLHYLPGDALGVWFDNDPALVREILDLLGIDPATEIQAGGKTLPVASALLSHFELTQNTPAFVKGYAPFADDDELDRIAADNAVLQGFVQSTPIADVLHRFPAKLTAEQFAGLLRPLAPRLYSISSSQAEVGDEVHLTVGAVRFEHEGRARAGGASGFLADRLEEDGTVRVFVERNDGFRLPEDSRKPIVMIGSGTGVAPFRAFVQQRAAENAEGKNWLIFGNPHFARDFLYQTEWQQFAKDGFLHRYDFAWSRDQEEKIYVQDKIREQAEGLWQWLQEGAHIYVCGDAAKMAKDVEAALLDVIIGAGHLDEEGAEEYLDMLREEKRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: MUTL_HAEDU
Sequence: MTQHLIHILPPQLANQIAAGEVVERPASVVKELVENSLDAGANHIQIDIEKGGAQLIRLRDNGCGIAKQDLTLALTRHATSKIATLADLEMILSLGFRGEALASISSVSRLTLTSRTANQTEAWQAYTQGREMNVEIQPASHPVGTTIEVANLFFNTPARRKFLRTDKTEFNHIDEVVRRIALAKPTISFTLTHNGKIIRQYRKVADQSVAQQQKRVAAICGNHFLQQATHIEWQHGDLHLYGWVSSPQLARPQNDLSYSYVNGRVMRDKIINHAVRQAYAELIPTGDQPAFILFLDLNPTELDVNVHPAKHEVRFHQARLIHGFILQGVQNALQAQLALTPTDNQTDSVAETKACYTADNNRAAAGSNIFSSTPYPRYSGATNRPTKTAQQCYAELINTDKNDNANVAPIIYAEPLTTQATPAITETADPYPHHSQVLALVENKALLLKEQEHFYVVPLKKLAQLQLTLSLAEKKSQPLLIPLSLSLDQAQAERWQQYQAQLLDSGFEIKQKHWQGQTRLSIIAVPQCLRQQNLQQLLLQLFNQHTDDLADFFAKNSELMTTYSLPEGTRLIANIEQQAKTQLADLKLAVDFSAYLT
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: NUOI_PARUW
Sequence: MRTTIHKVITMMKGLIIVLKHAFQTPVTLRYPEEKRILPARSRGRHYLTKWNDGLERCVGCELCAIVCPAQAIYVKPAANEPGHIHSHGERYASDFQINMLRCIFCGYCEEACPTGAIVLSNQYELSAYTREDMIYTKDRLTEKTPGESGRDPSREI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: COX6C_MOUSE
Sequence: MSSGALLPKPQMRGLLAKRLRVHIAGAFIVALGVAAAYKFGVAEPRKKAYAEFYRNYDSMKDFEEMRKAGIFQSAK
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 6C, Cytochrome c oxidase polypeptide VIc.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 6c family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: DER_ACIF5
Sequence: MTAVIALVGRPNVGKSTFFNRLTRTREALVADLPGLTRDRHYGTAQFEGRQYLVVDTGGFEPEEREGLVAAMAAQTRLAITEADAICFLVDAKEGLSTQDAEIAQELRRGGKPIYLVVNKMDAKGAVSELPEFYRLGLGTPYTISAAHGHGVEPLLEAIFSDLPTSEDDTADAARKGPRIAMLGRPNVGKSTLVNTMLGEKRVLVFDEPGTTRDSIRIPYERQGKPYVMIDTAGMRRRARVGEGLEKLSVLKTLSALREADVVLLVLDARLGIAEQDAHLVGVAVELGRPIVVVVNKWDGMTPEERKAVKQELERRLDFIRYAPVYTISALHGTGVGDLYKSIDQLWIDSRRHFSTAELNRALADVIETHQPPMVGGRRIKLRYCHQGGENPITLVFHGNQLTRLPGTYKRYLESAFRRALHLEAVPLRLVFRQGENPYDPQPKNGRQH
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: MIS18_SCHPO
Sequence: MSQTETSHSGYIDFKKESQPSVFQCKKCFQIVGDSNAWVISHREYLSFTLSDAVENSVRVEDTFKRSDDGLCVYSELSCTRCNEVIGKVYNSTPIYLDDIRDMYTFSMDKLQAYQLGNKTVNPEGLTRYQVDLEMREDIIKLKSFCLSLYEKFELHDETLRSVKETISSLKKPKIEGKEGKKEKARTYSKRTRK
What is the function of this protein?
Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A (PubMed:15369671, PubMed:24774534, PubMed:24789708, PubMed:25375240).  Maintains the deacetylated state of histones specifically in the central core of the centromeres (PubMed:15369671).
What are the official names of this protein?
Kinetochore protein mis18.
What is the protein family that this protein belongs to?
Belongs to the mis18 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Protein: ACYP_NITWN
Sequence: MHEVVRQVMIRGRVQGVGFRYWTMREAIRFGVGGWVRNRRDGSVEALFAGSTEAVAEMITRCRSGPEFARVDDIEDQPVAANALKMIRPGERFSQLPTV
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: PANC_GEOSM
Sequence: MIVIHSVAQMQQYARERRGDIALVPTMGYLHEGHASLMVEARKRAKYVVASIFVNPTQFGINEDLDSYPRDLEHDKEIAAKAGVDVIFAPTAADMYPDRYQSYLNVEEITVHLCGASRPGHFRGVTTVVAKLFNIVAPKVAFFGKKDFQQLAVIRRMVRDFNFDIEIVGMPIVREKDGLAMSSRNTKLSPAEREKALCLSRSIAAAKAAFRGGERSVAALQKVAAAVIEAENSPLIDYLEFRDQDSLLPLDKADERTLLALAVRVGSVRLIDNSILGED
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NLTP2_GOSHI
Sequence: MASSMSLKLACVVVLCMVVGAPLAQGAVTSGQVTNSLAPCINYLRGSGAGAVPPGCCTGIKSLNSAAQTTPVRQAACRCIKSAAAGITGINFGLASGLPGKCGVNIPYKISPSTDCNSVK
What is the function of this protein?
Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes.  May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.
What are the official names of this protein?
Non-specific lipid-transfer protein, LTP, GH3.
What is the protein family that this protein belongs to?
Belongs to the plant LTP family.