PharMolix/UniProtQA huggingface dataset:
Protein: ARI5B_HUMAN
Sequence: MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHAGPVKTEALGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGKAVAKVKCEARSALTKPKNNHNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAEVSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSAPLAPEKDSALVPGASKQPLTSPSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQPPLANQNETEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIARDDLCSSLSQTHHGQSTDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFKHEKLSRSDPHRCSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPSFLADFYSSPHLHSLYRHTEHHLHNEQTSKYPSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQDKKSAAAEAPTDDQPTDLSLPKNPHKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACRVSPMTMSGPKKYPESLSRSGKPHHVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPSKEVSGKEKASEQESEGSKAAHGGHSGGGSEGHKLPLSSPIFPGLYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL
What is the function of this protein?
Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development.  Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes.  The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver.  Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes.  Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation.  Represses the cytomegalovirus enhancer.
What are the official names of this protein?
AT-rich interactive domain-containing protein 5B, ARID domain-containing protein 5B, MRF1-like protein, Modulator recognition factor 2, MRF-2.
What is the protein family that this protein belongs to?
Belongs to the ARID5B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TCPG_CLAP2
Sequence: MEAQQDFTKHPEVAQDRLVLYVRKAIPAPTANSLKPLMILEALEIPYSIHLISSLSQETWYHEINPYKQLPALEDIDLVETSGGSKRRLNVFDSSAMLIYLCDKHDKDGLFIGRNATERAQVTSWLIAYAAGLGATGEWWLKMRHDENLKPALRVIENAIRREYDILEKRLGEPGQRWIALADRPTVADFAIQPLANPRVARNAAIDFEAWPRTKAWSEAVDRLAYIDRAKRLNNKLGMTEEEIELHGR
What is the function of this protein?
Glutathione S-transferase; part of the gene cluster that mediates the biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) lacking the reactive thiol group important for toxicity (PubMed:27390873).  Firstly, L-tyrosine is prenylated by tcpD, before undergoing condensation with L-glycine in a reaction catalyzed by the NRPS tcpP leading to the diketopiperazine (DKP) backbone (PubMed:27390873).  Afterwards the alpha-carbon of tyrosine is oxidized by the cytochrome P450 tcpC to form a hydroxyl group (PubMed:27390873).  However, in contrast other ETP biosynthesis pathways studied so far, tcpC is not able to bishydroxylate the DKP at both alpha-carbon positions, but hydroxylates the alpha-carbon of the tyrosine part and the nitrogen of the glycine part (PubMed:27390873).  The next steps involve an alpha,beta-elimination reaction catalyzed by tcpI, a methylation by the methyltransferase tcpN the action of the four enzyme cascade tcpG/K/J/I (PubMed:27390873).  Due to a dysfunctional cytochrome P450 monooxygenase tcpC, the pathway leads to the biosynthesis of probable non-toxic metabolites lacking the reactive thiol group (PubMed:27390873).
What are the official names of this protein?
Glutathione S-transferase tcpG, Thioclapurine biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: HSLO_LIMF3
Sequence: MEDYLVKSVAENGQFRAYAVNATALVEEAHQIHDTWSAASAALGRAMVGTLLLATSGLQGEAGMTVKIQGDGPVGFIVVDGTAQGTVKAYMQNPHVHLPLNAKGKIDVAGAVGKTGTLSVTKMAPGDKTPYTGEVNLVSGELGDDFTYYLAQSEQIPSAVGLSVFVQSDDHIEVAGGFLIQVLPGASDEAINHLETTLRELPLVSDLLREGKTPEQILETIFAGRDLKILEKMPVEYKCDCSKDRFEKALASLSKDDLQEMIDNDHGAEAVCRFCGHKYHFSEEELKYLVATK
What is the function of this protein?
Redox regulated molecular chaperone.  Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation.  Plays an important role in the bacterial defense system toward oxidative stress.
What are the official names of this protein?
33 kDa chaperonin, Heat shock protein 33 homolog, HSP33.
What is the protein family that this protein belongs to?
Belongs to the HSP33 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF3_STRAW
Sequence: MASESDRTVPDTRSASRPLADRVEELLATGGPLPIVAAGDPVLRRGAEPYDGQLGPGLLARFVEALRLTMHAAPGVGLAAPQVGVGLRIAVIEDPAPVPEEVGAVRGRVPQPFRVLVNPSYEAVGSDRAAFFEGCLSVPGWQAVVARPARVRLTALDEHGRAVDEEFTGWPARIVQHETDHLDGMLYLDRAELRSLSSNEAMALRWSQPTPERAAAALGFALPD
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 3, PDF 3, Polypeptide deformylase 3.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: NU5M_BRAFL
Sequence: MLELWGVLSLTSLGVMVIFLFSKIKSSFAESVKYAGYMNAVLLSILLMSDESEMLFLKWEWVKLGGYSLMISFRFDLYTCCFFVVGLYVTWNILMFSFYYMSTDPRIDLFCKYLGLFLIAMLLLVSAESLFQLLIGWEGVGIMSYLLISWWYARSDANTAALQAIFYNRVGDIGLLIMLMWSLVTLGDWSFTGLYALDFVNTFFLLGVVLAAAGKSAQLGLHPWLPAAMEGPTPVSSLLHSSTMVVAGVFLLIRFSPIILNHKEIQLMVFFLGTMTTLFSAICALAQNDMKKVVAFSTASQLGLMVTVVAGAGAPQLAFLHICMHAFFKAMLFMCSGGFIHGLQNEQDVRKMGGLHSAAPITSVCFFIGSAALMGVPFLAGFFSKDPIIEIININNLNSWAVGLVLIATSFTAAYSVRLLYFSVGGVSRMLVLQPMNEEYGNLIGPLQRLAYSSVIAGVVFIYFLSPNQISCLSLPLSLKLAAVFVTLVGGLIAWDVVNLLHREESVTNIPELAFEAQVGFYPLIMHKLIPKVWLNMGEMYQMQVMDRGWTELALPQGLGGNYKIMADNVVNAQTSLIKMYIAVMVMMGGLILGIMICL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOC1_SYNS9
Sequence: MTNSNLRTENHFDYVKITLASPERVMEWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCEKIFGPSKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGFIKLAAPVSHVWYLKGIPSYVAILLDMPLRDVEQIVYFNCYVVLDPGDHKDLKYKQLLTEDEWLEIEDEIYAEESEIENEPVVGIGAEALKQLLEDLSLEEVAQQLREDINGSKGQKRAKLIKRLRVIDNFIATGARPDWMVLDVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKMHQCGLPKEMAIELFQPFVIHRLIRQNIVNNIKAAKKLIQRADDEVMQVLQEVIDGHPIMLNRAPTLHRLGIQAFEPKLVDGRAIQLHPLVCPAFNADFDGDQMAVHVPLAIEAQTEARMLMLASNNILSPATGEPIITPSQDMVLGSYYLTALQPDATQPEFGDRSATFAGLDDVIHAFDDTRIGLHDWVWVRFNGEVEDDDELQEPLKSETLSDGTRIEQWTYRRDRFDEEGALISRYVLTTVGRVVMNHTIIDAVASA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: TPIS_HELAH
Sequence: MTKIAMANFKSAMPIFKSHAYLKELEKTLKPQHCDRVFVFPDFLGLLPNAFLHFTLGVQNAYPKDCGAFTGEITSKHLEELKINTLLIGHSERRVLLKESPNFLKEKFDFFKDKKFKIVYCIGEDLKTREKGLGAVKEFLNEQLENIDLDYQNLIVAYEPIWAIGTGKSASLEDIYLTHGFLKQHLNQKMPLLYGGSVNTQNAKEILGIDSVDGLLIGSTSLELENFKTIISFL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y078_THEAC
Sequence: MIIDDVIIGKGIGDIEFSRENTIFVLIAGTTEVSLRSGITAAGASPEFTRITPTVDAEIIGEGKCLSTADPPMTPEGIPTPAIVSRAILDLTGLRSLIVNGGFSVRPKTAFFETYIEPSRDPGLDRAVMEAERVMEAGRRLGKILDGNFKNIILGESFPGGTTTAYVVLRSLGIDSGTSSSMPVDPDNLKKKVAEESFRRRNVRSPLEAATEYGDNLMIFMIGLAESIRSSKMILGGGTQMANAANLIAKVNGRTDQVVATTQWVFSHRSDLFRILGLEDRSIISVMDFGRMRNNGLRLYNQGHVREGVGMGALYSYARIAGFSREEIESAIDDFYTTFLR
What are the official names of this protein?
UPF0284 protein Ta0078.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: LIPA_SACS2
Sequence: MEKKVQIAVYENENFKRVAEIVKKKSIATVCEEALCPNIMECWGSGTATFMIMGSICTRGCRFCYVLKGKPSPLDDEEPKRVAEAVKEMELDYVVITSVDRDDLSDGGAQHFANVVKTVKELNPGIIVEVLTPDFRGNIDAVKKVIDAGVDVFAHNVETVRRLTPIVRDPRASYEQSLNVLKYAENVIKKSSILLGLGETWDEIVETMRDLRSVGVSILVLSQYMRPSRKQLEVKKRYTLEEFKELEEIAYSMGFSAVISLPLARTSYKAKEAYFRAIENAKNHS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_LACPL
Sequence: MRRLLMKGIRFYQRAFSAFSPAHCRYYPTCSNYTLEAINRFGAVKGVLMGVARILRCQPLVKGGFDPVPAHFSLRRNPQYKEEDHRGKKR
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y742_CHLPN
Sequence: MNSKSAQKIIDSIKQILTIYNIDFDPSFGSSLSSDSDADYEYLITKTQEKIQELDKRAQEILTQTGMSKEQMEVFANNPDNFSPEEWLALEKVRSSCDEYRKETENLINEITLDLHPTKESKRPKQKLSSTKKNKKKNWIPL
What are the official names of this protein?
Protein CPn_0742/CP_0003/CPj0742/CpB0770.
What is the protein family that this protein belongs to?
Belongs to the chlamydial CPn_0742/CT_635/TC_0003 family.
Protein: YUAZ_ECO57
Sequence: MRLYACCGLLLCPAYPQHFAHGYVDKIPGYPGRAGTLTGLHPMQVCRCRRPPHPVTFRRSSSTRCGFGAAPAFVCGRPVTGAARPDGGRM
What are the official names of this protein?
Uncharacterized protein YuaZ.
Protein: YDEO_ECOLI
Sequence: MSLVCSVIFIHHAFNANILDKDYAFSDGEILMVDNAVRTHFEPYERHFKEIGFTENTIKKYLQCTNIQTVTVPVPAKFLRASNVPTGLLNEMIAYLNSEERNHHNFSELLLFSCLSIFAACKGFITLLTNGVLSVSGKVRNIVNMKPAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHAKNLIRVEGSVNKIAEQCGYASTSYFIYAFRKHFGNSPKRVSKEYRCQSHTGMNTGNTMNALAI
What is the function of this protein?
Induces the expression of gadE and mdtEF.  Could also regulate the expression of other genes involved in acid resistance.
What are the official names of this protein?
HTH-type transcriptional regulator YdeO.
Protein: Y9094_DICDI
Sequence: MKNKISYLNDDRHTIKRVKRSNPILFIKTPYSREAMKKKYFKFYLIHGFTTGYISRSGTLENKKKNLSFKKSKKNLNSYLNSLNKDGADQVNDENVQNEENDENQENDENQENDEYEENYDDEENQGNDEYEENESVENHFESDSEKGDFEEMDQTWKTNEKDNEKSDNNDNGDENNEKTKPNQQLQFIGLHRKKENQDEDSNKTKEIEQQQQNQKQQQVNDEDCSSNKQSNSFSGNVLAFGNMILKGLSFSDLTGNNNNNNINNNNNNNNKNNTNTNYTNNVVVNDNICEKDKENTQDQQTNTVTVSTTIINTTTTSTTSENSNTIDKSNDSINESGISSLDESNNSTSGDLISSNSSSFSSMDDI
What are the official names of this protein?
Uncharacterized protein DDB_G0290803.
Protein: HIS4_SALTI
Sequence: MIIPALDLIDGTVVRLHQGDYARQRDYGNDPLPRLQDYAAQGAGVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRTEEDVAALLKAGVARVVIGSTAVKSPDVVKGWFERFGAQALVLALDVRIDEHGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEICARYPQIAFQSSGGIGDIDDIAALRGTGVRGVIVGRALLEGKFTVKEAIQCWQNV
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXK_SALAR
Sequence: MIARIWSGESPLWRLLLPFSWLYGLVSGAIRLSYKLGLKRAWRAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQRRGVRVGVVSRGYGGKAVAYPLLLTPETTTAEAGDEPVLIYQRTGAPVAVAPERAAAVKAILAAHDVQIIITDDGLQHYRLARDIEIVVIDGVRRFGNGWWLPAGPMRERASRLKTVDAAIVNGGVARAGEIPMQLAPGLAVNLRTGARCDVAQLSNIVAMAGIGHPPRFFATLESCGAHPQKCVPLADHQTLAPADVQALVGEGQTLVMTEKDAVKCRAFAEDNWWFLPVDARLSGEKPDKLLEHITSLVR
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: MDE4_SCHPO
Sequence: MSTISTSTDSKLDNLGLSVTSRRNQILFYLSKALNLAHLLRSDSLQKSFLDALKQSATDSELLHKNLDEIKFLQNEKLNNEKLLEQEQNEANDYRLKVERLEHKISDYVQEINSLNSQLQIQKSNPEKHEDAVSQNRLRGSLDTVSSPSKTHKANKDEKATRLHLIIANLKKALKEKDAEVLNLQSHVSSKESELDRFKIKLETEESNWKVRLQVLESKLATQDRKLRMQKKSTERKSLLVSPRVSSPKLFSPSKQAIMGTRQPNATSGSPLSVTPFLQKTSTSIGLSSSPPQSSPSAQSSQPFSRDKYPHSMTVSPSNARYLKKHLDDTIPSNVSDINHNDHLKIPQSPSSLSPSKIPIRKKRKLKDTVSNCEFTEEDSESSFLLETIQPTKSTLRRSISPLKKRNDEINELKKGFTMKK
What is the function of this protein?
The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II.  May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules.
What are the official names of this protein?
Monopolin complex subunit mde4, Mei4-dependent protein 4.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localizes to the central core of the centromere.
Protein: RPOA_NEIMA
Sequence: MQNSTTEFLKPRQIDVNTFSATRAKVSMQPFERGFGHTLGNALRRILLSSMNGFAPTEVAIAGVLHEYSTVDGIQEDVVDILLNIKGIVFKLHGRSQVQLVLKKSGSGVVSAGDIELPHDVEILNPGHVICHLADNGQIEMEIKVEQGRGYQSVSGRQVVRDENRQIGAIQLDASFSPISRVSFEVEPARVEQRTDLDKLVLDIETDGSIDPEEAVRSAARILIDQMSIFADLQGTPVEEVEEKAPPIDPVLLRPVDDLELTVRSANCLKAEDIYYIGDLIQRTETELLKTPNLGRKSLNEIKEVLASKGLTLGSKLEAWPPVGLEKP
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: PAL_BRUME
Sequence: MRRIQSIARSPIAIALFMSLAVAGCASKKNLPNNAGDLGLGAGAATPGSSQDFTVNVGDRIFFDLDSSLIRADAQQTLSKQAQWLQRYPQYSITIEGHADERGTREYNLALGQRRAAATRDFLASRGVPTNRMRTISYGNERPVAVCDADTCWSQNRRAVTVLNGAGR
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Peptidoglycan-associated lipoprotein, PAL, 16.5 kDa minor OMP, 16 kDa OMP, Minor outer membrane protein Omp16, Outer membrane lipoprotein Omp16.
What is the protein family that this protein belongs to?
Belongs to the Pal lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: DER_PSYA2
Sequence: MSIKPVVALIGRPNVGKSTLFNQFTKSRQALVADLSGLTRDRQYGDATYEDKAFIVVDTGGIGEADDGRGDIDDYMSEQSYTAIHEADIIVFVVDARAGMIGADAEIGKFLHTLGKPVYVVANKVDGVHDSAPAEFYALGLGEPYPMAASHGRGVGNLLEVLTADMPNQENIIEPRGLKLAIIGRPNVGKSTLVNRLLGEDRVVVFDMPGTTRDSIYIPYKRDGKDYVLIDTAGVRRRGKIDEKVEKFSVIKTLQAIEDSNVTVIVIDAHEGIVDQDLHMIGYALDAGRALVVAINKWDGLTADQKNYIKIEMDRRFNFIPYVKVHQISALHGTGVGNLYPSILRAYQSSMFEVSTNRLTQILQDAVTANPPPTVAGRRIKLRYAHIGGHNPPVIVIHGNQTGSLPKSYQRYLENQFRQVFKLEGTPLNVVFKLNENPYANKSDTPTKAKTQQLRQRERNRAQKFTTKDKKPR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PZP_MOUSE
Sequence: MRRNQLPTPAFLLLFLLLPRDATTATAKPQYVVLVPSEVYSGVPEKACVSLNHVNETVMLSLTLEYAMQQTKLLTDQAVDKDSFYCSPFTISGSPLPYTFITVEIKGPTQRFIKKKSIQIIKAESPVFVQTDKPIYKPGQIVKFRVVSVDISFRPLNETFPVVYIETPKRNRIFQWQNIHLAGGLHQLSFPLSVEPALGIYKVVVQKDSGKKIEHSFEVKEYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPGLVTLRVCRKYSRYRSTCHNQNSMSICEEFSQQADDKGCFRQVVKTKVFQLRQKGHDMKIEVEAKIKEEGTGIELTGIGSCEIANALSKLKFTKVNTNYRPGLPFSGQVLLVDEKGKPIPNKNITSVVSPLGYLSIFTTDEHGLANISIDTSNFTAPFLRVVVTYKQNHVCYDNWWLDEFHTQADHSATLVFSPSQSYIQLELVFGTLACGQTQEIRIHYLLNEDIMKNEKDLTFYYLIKARGSIFNLGSHVLSLEQGNMKGVFSLPIQVEPGMAPEAQLLIYAILPNEELVADAQNFEIEKCFANKVNLSFPSAQSLPASDTHLKVKAAPLSLCALTAVDQSVLLLKPEAKLSPQSIYNLLPGKTVQGAFFGVPVYKDHENCISGEDITHNGIVYTPKHSLGDNDAHSIFQSVGINIFTNSKIHKPRFCQEFQHYPAMGGVAPQALAVAASGPGSSFRAMGVPMMGLDYSDEINQVVEVRETVRKYFPETWIWDLVPLDVSGDGELAVKVPDTITEWKASAFCLSGTTGLGLSSTISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNYMSHCIQIRVDLEISPDFLAVPVGGHENSHCICGNERKTVSWAVTPKSLGEVNFTATAEALQSPELCGNKLTEVPALVHKDTVVKSVIVEPEGIEKEQTYNTLLCPQDTELQDNWSLELPPNVVEGSARATHSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNHGGGNTPGNTWLTAFVLKAFAQAQSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMPLPVTHSAVRNALFCLETAWASISQSQESHVYTKALLAYAFALAGNKAKRSELLESLNKDAVKEEDSLHWQRPGDVQKVKALSFYQPRAPSAEVEMTAYVLLAYLTSESSRPTRDLSSSDLSTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKYGAATFTRSQKEVLVTIESSGTFSKTFHVNSGNRLLLQEVRLPDLPGNYVTKGSGSGCVYLQTSLKYNILPVADGKAPFALQVNTLPLNFDKAGDHRTFQIRINVSYTGERPSSNMVIVDVKMVSGFIPMKPSVKKLQDQPNIQRTEVNTNHVLIYIEKLTNQTLGFSFAVEQDIPVKNLKPAPIKVYDYYETDEFTVEEYSAPFSDGSEQGNA
What is the function of this protein?
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.  This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases.  When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase.  The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced).  Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
What are the official names of this protein?
Pregnancy zone protein, Alpha-2-macroglobulin, Alpha-2-M.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TX51A_SCOMU
Sequence: MPSLCIIALFGTLTFYTLIPSIHTLKCVRCDGPMSNYDCKTTYPAAEECPSLSGGSSNYCSKKETFTSNGNLEQTRRYCNSVAAPSTACTDLKTGGKLCEYSCNTDGCNSVAGMEPTRAVYFIAILMLA
What is the function of this protein?
Toxin that increase voltage-gated calcium channel (Cav) currents in DRG neurons by 70% and 120%, when 1 uM and 10 uM are tested, respectively.
What are the official names of this protein?
Omega-scoloptoxin(05)-Ssm1a, Omega-SLPTX(05)-Ssm1a, Omega-scoloptoxin-Ssm1a, Omega-SLPTX-Ssm1a.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-05 family.
What are the subcellular locations of this protein?
Secreted.
Protein: THII_AERPE
Sequence: MEYNVVLVRYSEIAVKGGYTRSRMERLLLRALEESLAAAGVEAEVERLQGRVLVRLRSPGDAAAAARASARVFGVKSVSPAVEVEYSGIEDLAEKAAEFFGERVRGRVFRVRARRSGVEGFTSKDVERLLGKLLLERGAGGVDLEKPEYTAYVEVRGRRAYFFDTINPGPGGLPVGSEEPSLALYSGGFDSGVAAWMIMRRGSPVHLAFYDFGVPEALEVAVEGAKTLAGEWAWGYRPRLYVVNFRGAALIVNGLVKPSYRTLVLRRLMLLHAQDLAAREGFEALVTGESVGQVASQTVRNLRLISSGLELPVLRPLAGMDKDEIVEKSREIGLYDIARRQVEVCGVDQPPNPRASPQGFRSEFEKVRDIFIPPPRVFDLKGESLHSILKTLGLRG
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
Probable tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INT5_HUMAN
Sequence: MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGLLLLRSLPPARAAVLDHLRGVFDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGLEDVVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYSGQHQRVPHATGALNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIISRVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGILGHLASRHGDSIRRELLRMFHDSLAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGELVDCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASGAGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALKNHVGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYAGLVVSLSGLLPLAFRSCLARVHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAHFGESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALSPSQLLGLVRAGVHRFFASLRLHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVSASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQSLLSLLVHCCSAPGGTECGECWGAPILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHARATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRGLLAALLGHWEASRHPDTTHSPWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKFIFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQGT
What is the function of this protein?
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.  The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable).  Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).
What are the official names of this protein?
Integrator complex subunit 5, Int5.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 5 family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Nucleus. Cytoplasm.
Protein: ACPS_BORHD
Sequence: MTKSIGCDIIKVTRFNSFLQNRKKLDRFFTQREIENLEMKGKGILESLAGKFSAKEALIKALSPLINTKIKYSLKDIEIIALPKGNIIFQLHNDIKVLIEQMDLKLYLTISHEREYAIAFVIVED
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.