PharMolix/UniProtQA huggingface dataset:
Protein: OGRL1_MOUSE
Sequence: MGNLLGGVSFREPTTVEDCDSTWQTDSEPEPEQPGPAGGGEGQQHDEPEQPKQPPERAGGRPRASPVPEDHAEAAGAEQGGESTEGNAKPKRSFYAARDLYKYRHQYPNFKDIRYQNDLSNLRFYKNKIPFKPDGVYIEEVLNKWKGDYEKLEHNHTYIQWLFPLREQGLNFYAKELTTYEIEEFKKTKEAIRRFLLAYKMMLEFFGIKLIDKTGNVARAGNWQERFQHLNESQHNYLRITRILKSLGELGYESFKSPLVKFILHEALVENTIPNIKQSALEYFVYTIRDRRERRKLLRFAQKHYTPSENFIWGPPKKELPERSKAQKTPTLPASGSNGQTSTHKKSKDSKISPGASHVNSKSVEEKKGASREPGEEADKPSPEPGSGDPKPRNTEKDSAADQSDSPPEKTVPDTAGKGECPTSSEKDGEGEDQSKDSENPENAGCHAEVVAQQNATNPQTSSG
What are the official names of this protein?
Opioid growth factor receptor-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the opioid growth factor receptor family.
Protein: AROC_STAA2
Sequence: MRYLTSGESHGPQLTVIVEGIPANLEIKVEDINKEMFKRQGGYGRGRRMQIEKDTVEIVSGVRNGYTLGSPITMVVTNDDFTHWRKIMGAAPISEEERENMKRTITKPRPGHADLVGGMKYNHRDLRNVLERSSARETAARVAVGALCKVLLQQLDIDIYSRVVEIGGIKDKDFYDSETFKANLDRNDVRVIDDSIAQAMRDKIDEAKNEGDSIGGVVQVVVENMPVGVGSYVHYDRKLDGKIAQGVVSINAFKGVSFGEGFKAAEKPGSEIQDEILYNSEIGYYRGSNHLGGLEGGMSNGMPIIVNGVMKPIPTLYKPLNSVDINTKEDFKATIERSDSCAVPAASIVCEHVVAFEIAKALLEEFQSNHIEQLQQQIADRRQLNVEF
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: PSTB_STAS1
Sequence: MANKQIIDKNDDLQAHTDRNDKPIATIESNHKENKIPDSEKKIVYSTKNLDLWYGENHALKNINLDILENNVTAIIGPSGCGKSTYIKALNRMVELVPSVKTAGKILYRDKNIFDDKHSVEKLRTNVGMVFQQPNPFPKSIYDNITYGPKIHGIKNKKVLDEIVEKSLRGAAIWDELKDRLDTNAYSLSGGQQQRVCIARTLAIEPDVILMDEPTSALDPISTLKVEELVQELKEKYSIIIVTHNMQQAARVSDKTAFFLNGYVNEYDDTDKIFSNPSDKQTEDYISGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL23_SHIFL
Sequence: MIREERLLKVLRAPHVSEKASTAMEKSNTIVLKVAKDATKAEIKAAVQKLFEVEVEVVNTLVVKGKVKRHGQRIGRRSDWKKAYVTLKEGQNLDFVGGAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: DAZP2_RAT
Sequence: MNSKGQYPTQPTYPVQPPGNPVYPQTLHLPQAPPYTDAPPAYSELYRPSFVHPGAATVPTMSAAFPGASLYLPMAQSVAVGPLGSTIPMAYYPVGPIYPPGSAVLVEGGYDAGARFGAGATTGSIPPPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW
What is the function of this protein?
In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity).  In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity).  This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity).  Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity).  Plays a role in stress granule formation (By similarity).
What are the official names of this protein?
DAZ-associated protein 2, Deleted in azoospermia-associated protein 2, Proline-rich transcript in brain protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.
Protein: GRDG_PEPAC
Sequence: MRLELGKIFIKDVQFGEKTTVEKGVLYVNKQEIIDLAMQDDRIKSVNVELARPGESVRIAPVKDVIEPRVKVEGSGAMFPGMTNKVKTVGSGRTHALVGSTVLTCGKIVGFQEGVIDMSGPIAKYCPFSETNNVCIVVEPVEGLETHAYEAAARMVGLKAAEYVGKAGLDVEPDEVVVYETKPLLEQIKEYPDLPKVAYVHMLQSQGLLHDTYYYGVDAKQFIPTFMYPTEIMDGAITSGNCVAPCDKVTTFHHLNNPVIEDLYKRHGKDLNSVGVILTNENVYLADKERCSDMVGKLVEFLGIDGVLITEEGYGNPDTDLMMNCKKCTQAGAKVVLITDEFPGRDGKSQSVADATPEADAVASCGQGNLIEHFPAMDKVIGMLDYVETMIGGYKGCINEDGSFDAELQIIIASTIANGYNKLTARFY
What is the function of this protein?
In the first step of sarcosine reductase, the substrate is bound to component PB via a Schiff base intermediate.  Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine.  By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state.  Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.
What are the official names of this protein?
Sarcosine reductase complex component B subunit alpha, Selenoprotein PB alpha.
Protein: RNFH_NEIG2
Sequence: MLEIEIVYGLPDRQVLKTMQLAEGTTVRTAALQSGLDGIFENLNLHSAPLGIFGKAVKDDTPLRDGDRIEVYRPLLIDPKEARRKRVQNQEE
What are the official names of this protein?
Protein RnfH.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: MMSA_PSEAE
Sequence: MSVPVRHLIAGAFVEGLGAQRIPVSNPLDNSTLAEIACASAEQVEQAVASARETFASWKETPVSERARVMLRYQALLKEHHDELAKIVSSELGKTFEDAKGDVWRGIEVVEHACNVPSLLMGETVENVARNIDTYSITQPLGVCVGITPFNFPAMIPLWMFPLAIACGNAFILKPSEQVPLTSVRLAELFLEAGAPKGVLQVVHGGKEQVDQLLKHPQVKAVSFVGSVAVGQYVYHTGTAHNKRVQSFAGAKNHMVIMPDADKAQVISNLVGASVGAAGQRCMAISVAVLVGAAREWIPEIRDALAKVRPGPWDDSGASYGPVINPQAKARIERLIGQGVEEGAQLLLDGRGYKVEGYPDGNWVGPTLFAGVRPDMAIYREEVFGPVLCLAEVDSLEQAIRLINESPYGNGTSIFTSSGAAARTFQHHIEVGQVGINIPIPVPLPFFSFTGWKGSFYGDLHAYGKQGVRFYTETKTVTARWFDSDSVAGTNFSIQMR
What are the official names of this protein?
Methylmalonate-semialdehyde dehydrogenase [acylating], MMSDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: RH28_ARATH
Sequence: MPSSFFFEDASDDELELIRNQEDSSEEDVKEGEAEEHEAGEDEDGEEEYEEEDDDEEEEDEKRKRDADAQSPWDFASYSSSVGEEHARRHTTSIDEKISKAIQHRPVPISINEEEEEEEEEEDASDAETDKQEEYLSEDDEAAEYKPEDATPKPFFSTVDGVSFHADTFMELNLSRPLLRACETLGYKKPTPIQAACIPLALTGRDLCASAITGSGKTAAFALPTLERLLFRPKRVFATRVLILTPTRELAVQIHSMIQNLAQFTDIKCGLIVGGLSVREQEVVLRSMPDIVVATPGRMIDHLRNSMSVDLDDLAVLILDEADRLLQTGFATEITELVRLCPKRRQTMLFSATMTEEVKELVKLSLNKPLRLSADPSARRPPGLTEEVVRIRRTREANQEAVLLSLCTRTFKSKVIIFSGTKQAAHRLKILFGLAGLKAAELHGNLTQAQRLDSLELFRKQEVDFLIATDVAARGLDIIGVQTVINYACPREIDSYVHRVGRTARAGREGYAVTFVTDSDRSLLKVIAKKVGSKLKSRVIPEQSIVKWSQIIDEMEDQYSAVISAERDERALRKAEMEFAKAENMLEHRDEIYARPKRTWFMTEKEKKLVAQAEKDSAGNPAGGELVSADRAEDLKMKEKRKREREKNLPRKKRRKLEAAREMLEDNEGEEEEEDEEGDEKRGRSRGKDKKKQETDKKGLTLKDLGYMRAKAVKAKQRAIDSGKMERPKPDKKQSRSKPRNQPRGEEMKDLFKSDMGEKKQGRGGAAAAAKPRTKSKNSFKSKARYKRR
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 28.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
Protein: RPC1_TRYBB
Sequence: MLKGSSSTSFLLPQQFVEPLPHAPVEISALHYGLLSRNDVHRLSVLPCRRVVGDVKEYGVNDARLGVCDRLSICETCGLNSIECVGHPGHIDLEAPVFHLGFFTTVLRICRTICKRCSHVLLDDTEIDYYKRRLSSSSLEPLQRTMLIKTIQTDAYKTRVCLKCGGLNGVVRRVRPMRLVHEKYHVEPRRGEGPRENPGGFFDAELRTACAYNKVVGECREFVHDFLDPVRVRQLFLAVPPGEVILLGLAPGVSPTDLLMTTLLVPPVPVRPRGCAGTTTVRDDDLTAQYNDILVSTDTMQDGSLDATRYTETWEMLQMRAARLLDSSLPGFPPNVRTSDLKSYAQRLKSKHGRFRCNLSGKRVDYSGRSVISPDPNLDVDELAVPLHVARVLTYPQRVFKANHELMRRLVRNGPHVHPGATTVYLAQEGSKKSLKNERDRHRLAARLAVGDIVERHVMNGDLVLFNRQPSLHRVSMMAHRARVLPFRTFRFNECCCAPYNADFDGDEMNVHFVQTEKARAEALQLMSTARNIISAKNGEPIIACTQDFLAAAYLVTSRDVFFDRGEFSQMVSHWLGPVTQFRLPIPAILKPVELWTGKQLFELIVRPSPEVDVLLSFEAPTKFYTRKGKHDCAEEGYVAFLDSCFISGRLDKKLLGGGAKDGLFARLHTIAGGGYTARVMSRIAQFTSRYLTNYGFSLGLGDVAPTPELNKQKAAVLARSVEVCDGLIKSAKTGRMIPLPGLTVKQSLEARLNTELSKVRDECGTAAVQTLSIHNNTPLIMVQSGSKGSALNIAQMMACVGQQTVSGKRILDAFQDRSLPHFHRFEEAPAARGFVANSFYSGLSPTEFFFHTMAGREGLVDTAVKTAETGYIYRRLMKAMENLSVRYDGTVRNTKGDVIQLRFGEDGLDPQLMEGNSGTPLNLEQEWLSVRAAYARWVVGLLAGSKTASDGNAIRDNENYFNEFISMLPTEGPSFVEACLNGDQEALKVCEEQESREDALHNSNGKTNDRESRPRTGRLRRAVLISHLVKVCSRKFKDDIQDFFVKKVREQQRIRNLLNLPNTSRERTEGGGDNSGPIANKRTKKRAPSLKVKDSKEGGRVSELRDLEMLQTELLPLTRGMVTRFIAQCASKYLRKACEPGTPCGAIAAQSVGEPSTQMTLRTFHFAGVASMSITQGVPRLVEVINANRNIATPVVTAPVLLMEGEENHCEIFRKRARFVKAQIERVLLREVVSEIVEVCSDTEFYLRVHLNMSVITKLHLPINAITVRQRILAAAGHTMSPLRMLNEDCIEVFSLDTLAVYPHFQDARWVHFSLRRILGLLPDVVVGGIGGINRAMISSNGTEVLAEGAELRAVMNLWGVDSTRVVCNHVAVVERVLGIEAARRVIVDEIQNILKAYSLSIDVRHVYLLADLMTQRGVVLGITRYGIQKMNFNVLTMASFERTTDHLYNAAATQRVDRDLSVSDSIIVGKPVPLGTTSFDLLLDGSISNDILPPQRCVKRGMGPNFHTAKRHHLVPLAAEGVFRLDLF
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Forms the polymerase active center together with the second largest subunit.  A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III.  A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC1, RNA polymerase III subunit C1, DNA-directed RNA polymerase III largest subunit, RNA polymerase III subunit C160.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSN2_EMENI
Sequence: MSDDDDFMHDSADEEYDFEYEDADDDETGDIGIENKYYNAKQIKVDNPEEAIDEFLGVPALEQDKGDWGFKGLKQAIKLEFKLGRYSDAVEHYRELLTYVKSAVTRNYSEKSINNMLDYIEKGSDDEKAYQCMEEFYSLTLNSFQNTNNERLWLKTNIKLARLWLERREYGQLSKKVRELHRACQREDGSDDPSKGTYLLELYALEIQMYAETKNNKRLKALYQRALRVRSAVPHPKIMGIIRECGGKMHMSEENWEEAQSDFFESFRNYDEAGSMQRIQVLKYLVLTTMLMKSDINPFHSQETKPYKTDPRISAMTDLVDAFQRDDIHAYEEVLSKNPDVLADPFIAENIDEVSRNMRTKAILKLIAPYTRFTLSFISKHIKISVTEAQDILSFLILDKKLNAKIDQESGTVVVESASDVERLRSVEEWNESLRTLWQVTLKDGDGFKNDDVSQPTGIGMRGPLLYQSGLDDDTAGLLRSSGHRFRRGGKGSKAGGGLGMKTGLF
What is the function of this protein?
Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity).  The CSN complex seems to link protein degradation to sexual development.  Required for fruit body formation.
What are the official names of this protein?
COP9 signalosome complex subunit 2, Signalosome subunit 2.
What is the protein family that this protein belongs to?
Belongs to the CSN2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EFPL_ECO45
Sequence: MPRANEIKKGMVLNYNGKLLLVKDIDIQSPTARGAATLYKMRFSDVRTGLKVEERFKGDDIVDTVTLTRRYVDFSYVDGNEYVFMDKEDYTPYTFTKDQIEEELLFMPEGGMPDMQVLTWDGQLLALELPQTVDLEIVETAPGIKGASASARNKPATLSTGLVIQVPEYLSPGEKIRIHIEERRYMGRAD
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: TAUB_SHIDS
Sequence: MLQISHLYADYGGKPALEDINLTLESGELLVVLGPSGCGKTTLLNLIAGFVPYQHGSIQLAGKRIEGPGAERGVVFQNEGLLPWRNVQDNVAFGLQLAGIEKMQRLEIAYQMLKKVGLEGAEKRYIWQLSGGQRQRVGIARALAANPQLLLLDEPFGALDAFTRDQMQTLLLKLWQETGKQVLLITHDIEEAVFMATELVLLSSGLGRVLERLPLNFARRFVAGESSRSIKSDPQFIAMREYVLSRVFEQREAFS
What is the function of this protein?
Part of the ABC transporter complex TauABC involved in taurine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Taurine import ATP-binding protein TauB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GAS2_MOUSE
Sequence: MMCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPTKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPVQSKSPTLKDMNPDNYLVVSATYKAKKEIK
What is the function of this protein?
May play a role in apoptosis by acting as a cell death substrate for caspases.  Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells.  May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis.  May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb.  May be involved in the membrane ruffling process.
What are the official names of this protein?
Growth arrest-specific protein 2, GAS-2.
What is the protein family that this protein belongs to?
Belongs to the GAS2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, stress fiber. Membrane; Peripheral membrane protein. Note=Component of the microfilament system (PubMed:1607387). Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts (PubMed:8120096). Mainly membrane-associated (PubMed:8120096). When hyperphosphorylated, accumulates at membrane ruffles (PubMed:8120096).
Protein: NSE4A_HUMAN
Sequence: MSGDSSGRGPEGRGRGRDPHRDRTRSRSRSRSPLSPRSRRGSARERREAPERPSLEDTEPSDSGDEMMDPASLEAEADQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDSPDFEFIVYDSWKITGRTAENTFNKTHTFHFLLGSIYGECPVPKPRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQVRNQGIIALSYRDWEEIVKTFEISEPVITPSQRQQKPSA
What is the function of this protein?
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination.  The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.  The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).  Is involved in positive regulation of response to DNA damage stimulus.
What are the official names of this protein?
Non-structural maintenance of chromosomes element 4 homolog A, NS4EA, Non-SMC element 4 homolog A.
What is the protein family that this protein belongs to?
Belongs to the NSE4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: Y680_HELP5
Sequence: MEKLPKKRVSKTKSQKLINSLTTQKNRAFLKKISASEMLLELEKGAFKKNEAYFISDEEDKNYVLVPDNVISLLAENARKAFEARLRAELERDIITQAPIDFEDVREVSLQLLENLRQKDGNLPNINTLNFVKQIKKEHPNLFFNFDNMFKQPPFNENNFENFDNSDEENF
What are the official names of this protein?
UPF0763 protein HPKB_0680.
What is the protein family that this protein belongs to?
Belongs to the UPF0763 family.
Protein: PPNP_MAGMM
Sequence: MLKVNEYFDGAVKSIGFQSETLPATVGVMAPGAYTFGTDQKETMTVVSGALTVKLPGQDGWQRFAAAEHFEVEANQSFELKVEVATAYLCTYG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.
Protein: Y2231_STUS1
Sequence: MRIPDFQQRLADIGAKPRHIGRMTRAWLKGLPLDVGRRQQQAEDFLPLSVREGLPALSLEIDALARLRSEHPAADGSARLLVELGDGQMVESVLLPRDGLCVSSQVGCAVGCVFCMTGKSGLLRQLGSAEIVAQVALARRFRPVKKVVFMGMGEPAHNLDNVLEAIDLLGTEGGIGHKNLVFSTVGDLRVFERLPQQRVKPALALSLHSTDGALRQALLPRAPQIAPEELVELGETYARATGFPIQYQWTLLKGINDNQEEMDGILRLLKGKYAVMNLIPYNSLEDDAYQRPEGERIVQIVRYLHSRGVLTKVRNSAGQDIDGGCGQLRARAEHVLGRRRPR
What are the official names of this protein?
Probable RNA methyltransferase PST_2231.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
Protein: CAPSP_ADE12
Sequence: MRRAVELQTVAFPETPPPSYETVMAAAPPYVPPRYLGPTEGRNSIRYSELSPLYDTTRVYLVDNKSSDIASLNYQNDHSNFLTTVVQNNDYSPIEAGTQTINFDERSRWGGDLKTILHTNMPNVNDFMFTTKFKARVMVARKTNNEGQTILEYEWAEFVLPEGNYSETMTIDLMNNAIIEHYLRVGRQHGVLESDIGVKFDTRNFRLGWDPETQLVTPGVYTNEAFHPDIVLLPGCGVDFTESRLSNILGIRKRQPFQEGFVIMYEHLEGGNIPALLDVKKYENSLQDQNTVRGDNFIALNKAARIEPVETDPKGRSYNLLPDKKNTKYRSWYLAYNYGDPEKGVRSWTLLTTPDVTGGSEQVYWSLPDMMQDPVTFRSSRQVSNYPVVAAELLPVHAKSFYNEQAVYSQLIRQSTALTRVFNRFPENQILVRPPAATITTVSENVPALTDHGTLPLRSSISGVQRVTITDARRRTCPYVYKALGIVSPRVLSSRTF
What is the function of this protein?
Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid.  Involved in virus secondary attachment to host cell after initial attachment by the fiber protein.  Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions.  Mediates initial virus attachment to CXADR-negative cells.  Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus.  As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.
What are the official names of this protein?
Penton protein, CP-P, Penton base protein, Protein III.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae penton family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Located at each vertex of the virion. Present in 60 copies per virion.
Protein: LEUD_RHOE4
Sequence: MESFTTHKGIGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAGWRTDPNFILNLAPYDKGSVLVAGPDFGTGSSREHAVWALSDFGFRVVIASRFADIFRGNAGKAGLVAAQVEQSDVELLWKLLEEQPGLELTVDLENRTVSAGTTVVPFNIDDYTRWRLLEGLDDIGLTLRQVEAISEFEKSRPSWKPTTLPARISQG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: PANC_PROMH
Sequence: MLIIETTLILRREIKRLKQEGKRIALVPTMGNLHQGHLKLIEEARIHADVVIASIFVNPMQFDREADLANYPRTLQEDCELLRDKHVDIVFAPSAKEMYPNGMENQTIVEVPVLSSVLEGASRPGHFRGVTTVVSKLFNLVQPDVALFGEKDYQQLQIIKKMVSDLCFDISIIPVPIVRDKTGLAFSSRNRLLSDNEKQQAPVLYQAMQQIAEQLKSGNLDVNQLLQTAKATLEQQGFRADECFICDAQTLAPLSEESRCAVILMAAWLGNTRLIDSQQVSLV
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNE_PSESM
Sequence: MSLPSLADFPAILLPFITRARQTWRTALTELSAEALASFEAWPEARRTAFDRVCAASDFVTEQICRDPQMLLQLAGSGELERSFSVGELRGQIADALSSAVTEDELGRNLRRQRARQQVRIIWRDLTRQADLIETCRDLSEMADASIDLAYQWLYPRHCQQFGTPTGRHCGLPQQMVILGMGKLGAVELNLSSDIDLIFAYPEGGETVGTKRALDNQEFFIRLGQRLIKALDPVTVDGFVFRVDMRLRPYGSSGALVLSFNALEQYYQDQGRDWERYAMIKARVVGGDLAAGAELLEMLRPFVYRRYLDFSAIEALRTMKQLIQQEVKRKGMAENIKLGAGGIREVEFIAQAFQLIHGGRDLSLQQRPLFNVLKTLEGQGYLPSAVTEELREGYEFLRYTEHAIQAIADRQTQMLPDNEQDQARIALIMGFADWASFHERLMYWRSRVSWHFRQVIADPDSDPDDELQDDSEVVVGGEWLPLWEESQDEDAAGRQLLQAGFVDTGKALKSLADLRSSPNLRSMQRLSRERLDAFIPRLLAQAVEHEKPDLVLERVLPLVEAVARRSAYLVLLTENPDALRQLLTLCAASPWIAEQIARFPLLLDELLNEGRLFNPPLAPELAAELRERLVRIPEDDLEQQMEALRHFKLAHSLRVAASEISGSLPLMKVSDYLTWLAEAILDQVLALAWRYSVARHGTPSRPDGTLCDPGFVIVGYGKVGGIELGHGSDLDLVFIHDGDLQTETDGAKPIDSAQFFTRLGQRVIHLLTTQTNSGQLYDVDMRLRPSGASGLLVSSLGAFARYQANEAWTWEHQALVRARVLTGSRDVGEQFEKVRADVLGRERDLDTLRAEVSEMRAKMRDNLGTRLTAAGRAANAFEASVPFDLKQDAGGIVDIEFMVQYAALAWSREHPALLQHTDNIRILEGLEEAGLLPDVDASLLREAYKAYRSAAHRQALQKQAGVVGGDQFHAQRREVMRIWAQMGLS
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: IFNTA_SHEEP
Sequence: MAFVLSLLMALVLVSYGPGGSLGCYLSQRLMLDARENLRLLDRMNRLSPHSCLQDRKDFGLPQEMVEGDQLQEAQAFCVLYEMLQQSFNLFHTERSSAAWNTTLLEQLCTGLQQQLEDLDTCRGPVMGEKDSELGKMDPIVTVKKYFQGIHDYLQEKGYSDCAWETVRVEMMRALTSSTTLQKRLTKTGGDLNSP
What is the function of this protein?
Paracrine hormone primarily responsible for maternal recognition of pregnancy.  Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium.  This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity.  This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus.  In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties.  In contrast with other IFNs, IFN-tau is not virally inducible.
What are the official names of this protein?
Interferon tau-10, IFN-tau-10, Antiluteolysin, TP-02, Trophoblast antiluteolytic protein, Trophoblast protein 1, TP-1, Trophoblastin.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted into the uterine lumen.
Protein: Y7140_DICDI
Sequence: MSNQQKQLQLPSASIKKPKEKQKSQIVRIIQSKFKDYQYMFLLIKLSTYSKFDQDDDFNTFLSFLESEYKFSKQLSSKEIVLSLRYTKNTKITPYINHSKFETEKKIS
What are the official names of this protein?
Putative uncharacterized protein DDB_G0286769.