PharMolix/UniProtQA huggingface dataset:
Protein: GSHB_RAT
Sequence: MATSWGSILQDEKQLEELAQQAIDRALAEGVLLRSAKNPSSSDVVTYAPFTLFPSPVPSTLLEQAYAVQMDFNILVDAVSQNSAFLEQTLSSTIKKDEYTARLFDIYKQVLKEGIAQTVFLGLNRSDYMFQCSADGSKALKQIEINTISASFGGLASRTPAVHRHVLNVLNKTNEASKILSNNPSKGLALGIAKAWELYGSANAVVLLIAQEKERNIFDQRAIENELLDRKIHVIRRRFEDVSERGSLDQNRRLFMEDQEVAVVYFRDGYMPSQYNAQNWEARLLLERSCAAKCPDIATQLAGTKKVQQELSRVGLLEALLPGQPEAVARLRATFAGLYSLDMGEEGDQAVAEALAAPSHFVLKPQREGGGNNFYGEEMVHALEQLKDSEERASYILMEKIEPEPFRNCLLRPGSPAQVVQCISELGIFGVYVRQGTTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
What is the function of this protein?
Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7862666).  Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:7862666).  Participates in ophthalmate biosynthesis in hepatocytes (By similarity).
What are the official names of this protein?
Glutathione synthetase, GSH synthetase, GSH-S, Glutathione synthase.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic GSH synthase family.
Protein: CRK36_ARATH
Sequence: MERSNLFHIPCFLLLFLLFNINGVHTTFVCGDEDFSPNTSYVENLESLLPSLASNVIRERGFYNVSLDGVYALALCRKHYEVQACRRCVDRASRTLLTQCRGKTEAYHWDSENDANVSCLVRYSNIHRFGKLKLEPIGNVPHSSLDPSSNLTRISQEFAARANRTVEVASTADESSVLKYYGVSSAEFTDTPEVNMLMQCTPDLSSSDCNHCLRENVRYNQEHNWDRVGGTVARPSCYFRWDDYRFAGAFDNLERVPAPPRSPQTRQDYRVKKGRMFQPWSVVVVVFPTGINLAVFVAFVLAYRRMRRRIYTEINKNSDSDGQATLRFDLGMILIATNEFSLENKLGQGGFGSVYKGILPSGQEIAVKRLAGGSGQGELEFKNEVLLLTRLQHRNLVKLLGFCNEGNEEILVYEHVPNSSLDHFIFDEDKRWLLTWDVRYRIIEGVARGLLYLHEDSQLRIIHRDLKASNILLDAEMNPKVADFGMARLFNMDETRGETSRVVGTYGYMAPEYVRHGQFSAKSDVYSFGVMLLEMISGEKNKNFETEGLPAFAWKRWIEGELESIIDPYLNENPRNEIIKLIQIGLLCVQENAAKRPTMNSVITWLARDGTFTIPKPTEAAFVTLPLSVKPENRSMSERKDKDPFSVDEVSITVLYPR
What is the function of this protein?
Forms a complex with CRK45 that may negatively control abscisic acid (ABA) and osmotic stress signal transduction.  Can phosphorylate CRK45 in vitro (PubMed:22225700).
What are the official names of this protein?
Cysteine-rich receptor-like protein kinase 36, Cysteine-rich RLK36.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: IF3_MYCCT
Sequence: MENRNRNSRPIKNQDPVNEFIRAHQVLVIDEDKQNLGVMSKRQALEIAKSKNLDLYQVGVQPDGTVITRIVNFGKLKYEQQKKSKEAKKHQTKIENKEIRITVNIGKHDLETKARKAKEFLEEGSRVKVSLKFRGREVVYLDLGQQTLNNFFELVSDVGKMEKEAKLNGKFLDMYIVPKKN
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAT_XENLA
Sequence: MALKAEDSFDIYSQLIQSFCRYAENTTVSESQSPAFNAQKEFQTCQDHACCTHSEAHTHILMQQWQLLEEQWEYIDHLKTDVAALKQLLHGFMNSLSGTDSGMEGTNHFLPPHQNPTLLKDEEIVASALNRPSVDINGFEENITTGAQIHAAFTKSPKKMPATSTPRKSEVLWSCSPTLATDGYFMLPDIILNPLDGKKLVSMLRSSNYEPHRFAELLFQHHVPHSLFQLWANKVNFDGSRGKLGLPRNLMIDILHQTSKRFVLGPKEKRKIKTRLNLLLRTRQDRAWWDVGL
What is the function of this protein?
Probably plays a role in germ plasm formation, positioning and maintenance.
What are the official names of this protein?
Protein Pat, Primordial germ cell-associated transcript protein, Xpat.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Unlike the transcript, the protein is not exclusively localized to germ plasm but is also present in the nuclei of early oocytes, of later stage primordial germ cells (PGCs) and of some somatic cells, as well as in their cytoplasm (PubMed:16216237).
Protein: AGRL4_RAT
Sequence: MRLLLLLVGLSTLLNHSYTQNCKTPCLPNAKCEVLDEVAACFCSTGYTGNGITICEDVDECNETSVCGDHAVCENTNGGFSCFCVEGYQTSTGKTQFTPNDGSYCQDVDECNETSVCGDHAVCENTNGGFSCFCVEGYQTSTGKTQFTPNDGSYCQEIVNSNCHLEHDCIAANINKTLKRIGPITEQLTLLHEIYKNSEAELSLVDIVTYIEILTESSSLQGYIKNTTSPKDAYFGSALTEFGKTVNNFVEKNTHEMWDQLPTNRRRLHLTKLMHAAEHVTLQISQNIQKNTQFDMNSTDLALKVFVFDSVHMKHTHPHMNVDGGYVKISPRRKSAYDPNGNVIVAFLCYRSIGPLLSSSDDFLLGAQSDNSKGKEKVISSVISASISSNPPTLYELEKITFTLSHVKLSDKHQTQCAFWNYSVDDMNNGSWSSEGCELTYSNDTHTSCRCSHLTHFAILMSPSTSIEVKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAQLVFLVGININTNKLVCSIIAGLLHYFFLAAFAWMCIEGIYLYLIVVGLIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWTFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFECLR
What is the function of this protein?
Endothelial orphan receptor that acts as a key regulator of angiogenesis.
What are the official names of this protein?
Adhesion G protein-coupled receptor L4, EGF,latrophilin and seven transmembrane domain-containing protein 1, EGF-TM7-latrophilin-related protein, ETL protein.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PHS_BRUC2
Sequence: MARNRLTESEMNEALRALDGWQKVDGREAITRSFKFKDFSTAFGFMAQAALYAEKLDHHPEWFNAYNRVDVTLATHSENGVTELDIKMARKMNAIAG
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: LMO3_XENLA
Sequence: MHRREQSFGIQMLSVQPDTKPKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGVTGNCAACSKLIPAFEMVMRAKENVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQTDYEEGLMKEGYSAQVR
What are the official names of this protein?
LIM domain only protein 3, LMO-3, LIM domain only protein 1, LMO-1, xLMO1.
Protein: T2C1_PBCVI
Sequence: MDIRRKRFTIEGAKRIILEKKRLEEKKRIAEEKKRIALIEKQRIAEEKKRIAEEKKRFALEEKKRIAEEKKRIAEEKKRIVEEKKRLALIEKQRIAEEKIASGRKIRKRISTNATKHEREFVKVINSMFVGPATFVFVDIKGNKSREIHNVVRFRQLQGSKAKSPTAYVDREYNKPKADIAAVDITGKDVAWISHKASEGYQQYLKISGKNLKFTGKELEEVLSFKRKVVSMAPVSKIWPANKTVWSPIKSNLIKNQAIFGFDYGKKPGRDNVDIIGQGRPIITKRGSILYLTFTGFSALNGHLENFTGKHEPVFYVRTERSSSGRSITTVVNGVTYKNLRFFIHPYNFVSSKTQRIM
What is the function of this protein?
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-RGCY-3' and cleaves after G-2.  In the presence of ATP, there is a relaxation of its specificity and it can cleave 5'-RGCN-3' and 5'-YGCY-3', but not 5'-YGCR-3' (R. CviJI* activity).
What are the official names of this protein?
Type II restriction enzyme CviJI, R.CviJI, Endonuclease CviJI, Type-2 restriction enzyme CviJI.
Protein: MURD_SHIDS
Sequence: MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGSLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWINDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGVQLAALRPEVAEKTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCLT1_CHICK
Sequence: MVSWKGIYFVVALFLGSFFGSIFMLGPFLPLMFISPAWYRWITDRIVATWLTLPVALLEMVFGAKVVVTGDGFIPGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREGNNLDAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGKCFDETGQSIIPPCKSELRVLAVKCISLLYWTVFPMGTFALLYLYSFARWYFAAMIIIFVAQQKIFGGLELIELACHQYFKKQQKHDDTKMKKK
What is the function of this protein?
Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity).  Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity).  Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).  Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (By similarity).  Required for establishment of the hematopoietic and endothelial lineages (By similarity).
What are the official names of this protein?
Lysocardiolipin acyltransferase 1, 1-acylglycerol-3-phosphate O-acyltransferase 8, 1-AGP acyltransferase 8, 1-AGPAT 8, Acyl-CoA:lysocardiolipin acyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ACP_CHRSD
Sequence: MSTIEERVKKVVAERLNVKEEDIQNTSSFTEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQEAIDYVVAHQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGZ_ERWT9
Sequence: MGPVMLDVLGCELDAEEREILQHPLTGGLILFSRNYHDPAQLRELVRQIRAASRHRLVVAVDQEGGRVQRFREGFTRLPAMQAFSALNPSAEAETLAQQAGWLMASEMIAMDIDISFAPVLDIGYGSAAIGERSFHEDPAIALQMARCFIRGMREAGMKTTGKHFPGHGAVSADSHKETPRDTRSEAEIRRHDMPIFQQLIAERALDAIMPAHVIYTEVDPRPASGSSHWLKTVLRQELGFDGVIFSDDLSMEGAAIMGSYAERGQAALDAGCDMILVCNNREGAVSVLDNLPAMEADRVARLYHRGDFTRQQLIDSSRWKETSVALDRLQGRWLNHKAAAGR
What is the function of this protein?
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
What are the official names of this protein?
Beta-hexosaminidase, Beta-N-acetylhexosaminidase, N-acetyl-beta-glucosaminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H32_ONCMY
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.2.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: DAPH_BACC3
Sequence: MKMMDANEIISFIQKSEKKTPVKVYIKGDLKEVTFPETVQAFVNKKSGVLFGEWSEIKTILDENSKYIVDYVVENDRRNSAIPMLDLKGIKARIEPGAIIRDHVEIGDNAVIMMNATINIGAVIGEGSMIDMNAVLGGRATVGKNCHVGAGAVLAGVIEPPSAKPVIVEDDVVIGANVVVLEGVTVGKGAVVAAGAVVTEDVPPYTVVAGTPARVIKEIDEKTKAKTEIKQELRQLNPEK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: GLYR2_ARATH
Sequence: MPLVSLSFASSSSKAMALCSICPRIPLRFRPKPISPFLSKPQICLAYRVYSSLQSTTPSTRDELGTVSIGFLGMGIMGSPMAQNLIKAGCDVTVWNRTKSKCDPLVGLGAKYKSSPEEVTATCDLTFAMLADPESAIDVACGKNGAIFGISSGKGYVDVSTVDVASSILISKQIKDTGALFLEAPVSGSKKPAEDGQLIFLTAGDKPLYEKAAPFLDIMGKSKFYLGEVGNGAAMKLVVNMIMGSMMASFAEGILLSQKVGLDPNVLVEVVSQGAINAPMYSLKGPSMIKSVYPTAFPLKHQQKDMRLALGLAESVSQSTPIAAAANELYKVAKSYGLSDEDFSAVIEALKAAKSREA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate to glycolate as well as succinic semialdehyde (SSA) to gamma-hydroxybutyrate in vitro.  May function in redox homeostasis and play a role in oxidative stress tolerance by detoxifying glyoxylate and SSA generated in glycolate metabolism and GABA metabolism, respectively.
What are the official names of this protein?
Glyoxylate/succinic semialdehyde reductase 2, chloroplastic, AtGLYR2, AtGR2, SSA reductase 2.
What is the protein family that this protein belongs to?
Belongs to the HIBADH-related family. NP60 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RF1M_CAEEL
Sequence: MLKRHQQLLFRLIRQSVLHQSSPTSSSASSTLLNSENGEKFVKTVVDRLAQCQAGNATAAPEQISYWESISKQSAKVSDGRSELSQLRTIINDPKETEEMRKLAEVDVESIEENLETELQELAVKIVPLNNLDVLSKCQIELSCGAGGQEAMLFTGELLDMYQKLAAVNSWKWDPLQVDNVPLGGVRSALIAVSGEKVYAKMRFEAGVHRVQRVPVNDSRMHTSTASISVLPEPEEVSVVVPSDSVKIEAMRASGPGGQNVNKRSTAVRMTHKETGIAVHCMDERFQHLNIQIAYKRLAAILMQKQVDAMLEKIVSKRKLQVGSKARAEKIRTYNFQHDRVTDHRIQMSITGVAEFLSAGETLQTMIERLQEQHLEDRLDHIIENCIVE
What is the function of this protein?
Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.
What are the official names of this protein?
Probable peptide chain release factor 1, mitochondrial, MRF-1, MtRF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PCKA_STAA1
Sequence: MSVDTYTETTKIDKLLKKPTSHFQLSTTQLYNKILDNNEGVLTELGAVNASTGKYTGRSPKDKFFVSEPSYRDNIDWGEINQPIDEETFLKLYHKVLDYLDKKDELYVFKGYAGSDKDTMLKLTVINELAWHNLFAKNMFIRPESKEEATKIKPNFTIVSAPHFKADPEVDGTKSETFVIISFKHKVILIGGTEYAGEMKKGIFSVMNYLLPMQDIMSMHCSANVGEKGDVALFFGLSGTGKTTLSADPHRKLIGDDEHGWNKNGVFNIEGGCYAKAINLSKEKEPQIFDAIKYGAILENTVVAEDGSVDFEDNRYTENTRAAYPINHIDNIVVPSKAAHPNTIIFLTADAFGVIPPISKLNKDQAMYHFLSGFTSKLAGTERGVTEPEPSFSTCFGAPFFPLHPTVYADLLGELIDLHDVDVYLVNTGWTGGKYGVGRRISLHYTRQMVNQAISGKLKNAEYTKDSTFGLSIPVEIEDVPKTILNPINAWSDKEKYKAQAEDLIQRFEKNFEKFGEKVEHIAEKGSFNK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG044_VACCA
Sequence: MATKLDYEDAVFYFVDDDKICSRDSIIDLIDEYITWRNHVIVFNKDITSCGRLYKELMKFDDVAIRYYGIDKINEIVEAMSEGDHYINFTKVHDQESLFATIGICAKITEHWGYKKISESRFQSLGNITDLMTDDNINILILFLEKKLN
What is the function of this protein?
Virulence factor that affects the acute immune response to infection.  Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation.  Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation.
What are the official names of this protein?
Protein K7.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG044 family.
Protein: GCST_PECAS
Sequence: MAKQTPLYQQHLADGAKMVDFHGWMMPLHYGSQLDEHHIVRRDAGIFDVSHMTIVDLHGVRTREFLRYLLANDVAKLTQPGKALYTGMLNASGGVIDDLIVYFLTEDYFRLVVNSATREKDLAWIEQHAAAFGVDIRERDELALVAVQGPQAQEKVQGLLKAKGLSDEDVAAVASMKPFFGKQAGDFFVATTGYTGEAGYEIALPNEQVVDFWQQLLAVGVKPCGLGARDTLRLEAGMNLYGQDMDEGISPLAANMGWTIAWQPEDRQFIGREALVHQREKGTEQLVGLVLTEKGVLRNDLSVRFTDSDGVMREGVITSGSFSPTLGVSIALARVPAGIGEQAIVQIRNRELPVRVTKPGFVRAGKAIVQY
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MNME_STRT1
Sequence: MSITKEFDTITAISTPLGEGAIGIVRLSGTDAIAIANKVFKGKNLETVDSHTINYGHIVENNEIIDEVMVSVMRAPKTFTREDVVEINTHGGVAVTNEILQLLIRSGARMAEPGEFTKRAFLNGRIDLTQAEAVMDLIRAKTDKAMTVAVSQLDGSLKNLINNTRQEILNTLAQVEVNIDYPEYDDVEEVTTNLVREKTQEFQALLENLLATAKRGKILREGLSTAIIGRPNVGKSSLLNNLLREEKAIVTDIEGTTRDVIEEYVNIKGVPLKLIDTAGIRDTDDVVEKIGVERSKKALEEADLVLLVLNSSEPLTDQDRTLLDISQNSNRIILLNKTDLPQAIQTEELPEDLIPISVLKNENIDKIEDRINQLFFDNAGLVEKDATYLSNARHISLIEKALESLEAVNQGLELGMPVDLLQVDMTRTWEILGEITGDAAPDELITQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_LEPBL
Sequence: MNFQSKFLTRSQSLKSLLCVGLDPDYCKLPEIIKRSPEPLVHFCREIIDATAPYAVAYKPNIAFFEVFGSSGIRQFEKVIGHLKNNYPQIPIVADIKRGDLDNTARQYARYYFGDLQVDSLTLSPYMGLDTLRPFLEYQDHLVFWLCLTSNPDSIQFQKKRFSETGRTLYEEVAYVANSISPLNLGFVVGATNTYELEILRKQNPDRIFLIPGFGAQGAKLDDLLPVCGRYSLINSSRGIHFASDGLDFAARANQEAEKIHNAMQARFVFL
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: GLMU_CLOPS
Sequence: MNKCAIILAAGQGTRIKSKLPKVLHKACGKEMVNHVIDAMRNAEIDDVNVIIGKGAELVKERTTSKNVSYSLQAEQLGTGHAVKCAKDFLEGKTGVVAIFTGDAPLIKAETVKNLVDTHINEKNSATLLTSVIENPTGYGRIVRNGESVEKIVEHKDCNEQEIKIQEVNAGMYCFDIESLLTSLEQLSNDNAQGEYYLTDVIEILKKDNKKVGAMITDFEETLGVNSRAELAKVESIMRNRINRTHLDNGVTIIDPLNTYIEPEVVIGKDTIIYPGNVIEGKTVIGEDCILYPNSRINNSTIGNGVEIQSSVILDSKIGDETTVGPFAYVRPESNIGEHVRIGDFVEIKKSTIGNNTKVSHLTYIGDAEVGERCNFGCGTVVVNYDGKKKHKTIIGDDSFIGCNTNLVSPVEVKDNTYIAAGSTITKEVPEGSLAIARAKQQNIEGWVERKKLK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_DECAR
Sequence: MKTAMELRSGNVIMVGADPLVVQKSEYNKSGRNAAVVKMKLKNLLTGAASEAVYKADDKFEVVVLDKKEVTYSYFADPMYVFMDADYEQFEVEAENMTDALKYLEDGLACEVVFYNGKAISVELPNSVVREVVYTEPAVKGDTSGKVMKPAKLATGFELPVPAFVSIGDKIEIDTRTDEYKNRVK
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAP_EBOZM
Sequence: MDSRPQKIWMAPSLTESDMDYHKILTAGLSVQQGIVRQRVIPVYQVNNLEEICQLIIQAFEAGVDFQESADSFLLMLCLHHAYQGDYKLFLESGAVKYLEGHGFRFEVKKRDGVKRLEELLPAVSSGKNIKRTLAAMPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTAWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDAVISNSVAQARFSGLLIVKTVLDHILQKTERGVRLHPLARTAKVKNEVNSFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLFPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAESRELDHLGLDDQEKKILMNFHQKKNEISFQQTNAMVTLRKERLAKLTEAITAASLPKTSGHYDDDDDIPFPGPINDDDNPGHQDDDPTDSQDTTIPDVVVDPDDGSYGEYQSYSENGMNAPDDLVLFDLDEDDEDTKPVPNRSTKGGQQKNSQKGQHIEGRQTQSRPIQNVPGPHRTIHHASAPLTDNDRRNEPSGSTSPRMLTPINEEADPLDDADDETSSLPPLESDDEEQDRDGTSNRTPTVAPPAPVYRDHSEKKELPQDEQQDQDHTQEARNQDSDNTQSEHSFEEMYRHILRSQGPFDAVLYYHMMKDEPVVFSTSDGKEYTYPDSLEEEYPPWLTEKEAMNEENRFVTLDGQQFYWPVMNHKNKFMAILQHHQ
What is the function of this protein?
Oligomerizes into helical capsid to encapsidate the viral genome, protecting it from nucleases and the cellular innate immune response (PubMed:26119732, PubMed:25865894, PubMed:30333622, PubMed:16719918).  VP35 binds to and stabilizes monomeric NP, keeping it soluble (PubMed:26119732, PubMed:25865894).  Upon virus replication, NP is recruited to bind cooperatively viral genomic RNA and VP35 is released (PubMed:29144446).  The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication.  The nucleocapsid is helical with a pitch of 10. 81 NP per turn and a diameter of about 22nm (PubMed:22247782).  Each NP binds to six nucleotides of viral genomic RNA, three being exposed to the solvant and three hidden into the nucleocapsid (PubMed:30333622).  Recruits also host PPP2R5C phosphatase to dephosphorylate VP30 and thereby promote viral transcription (PubMed:29290611, PubMed:27755595).  Upon virion assembly and budding, NP binds to VP24 and possibly host STAU1 (PubMed:28794491, PubMed:30301857).
What are the official names of this protein?
Nucleoprotein, Ebola NP, eNP, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the filoviruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.