PharMolix/UniProtQA huggingface dataset:
Protein: RF1_STACT
Sequence: MFDQLDIVEERYEQLNELLSDPDVVSDSNKLREYSKEQSDLQKTVDVYRQYKQNKEDIDEIVEMLSETSDKEEVDMLKADMNELKDTLPGLEEELKMLLIPKDPNDDKNVVVEIRAAAGGDEAAIFAGDLYRMYTRFSEGLGYKTGVIEMNDSDHGGFKEISFTINGQGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVAVLPEAEDVEVDIKDADLKIETYRSSGAGGQHVNTTDSAVRITHLPTGIIATSSEKSQIQNREKALKVLKARVYDMKLQEEQEKYDSERKSAVGTGDRSERIRTYNYPQNRVTDHRIGLTIQKLDQIVEGKLDEIIDALTMSEQTEKLKELNNVDL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLM6_PLABA
Sequence: MTNFCIKSYLFLYLSFLLFFDIITIFHVSSIRISTVLKNDKKKKNFNTSLVEENKKYLFNEIKLNNRFKNDIKGYIQNINNFHSIIESKIPNSLLYVHEDLINFHNSQFIGDIEIGNPPQSFKVVFDTGSSNFAIPSTKCVKGGCTLHNKFDAKKSRTFMSNLKNKKESIYTYVQYGTGKSILEHGYDDVYMKGLKINKQCIGLIIEESMHPFSDLPFDGIVGLGFSDPDNSFQTKYSKSLIETIKEQNLLQQNIFSFYVPKELEKSGAITFGRANSKYAIEGEKIEWFPVISMYFWEINLLGILLPDKNFEICSNKKCRAAVDTGSSLITGPSSLMQPLIENINLEKDCSNISSLPIISFVLKNVEGKTVILDFTPDDYILQENSEEDNSSQCVIGLMSLDIPPPRGPIFIFGNVFIRKYYTIFDNDHKLVGVVKSNHNF
What is the function of this protein?
During the development in the mosquito midgut, plays a role in sporozoite egress from oocysts.
What are the official names of this protein?
Plasmepsin VI, Plasmepsin 6.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: G6PI_DROYA
Sequence: MAGPLPPLNQEAAFQKLQEYYDSSGKDLNIKDLFVKDAKRFSKYSLRLHTQNDGEILLDYSKNRINDEVWDLLLALAKVRRVDAARDAMFSGQHINITENRAVLHTALRNRGTDPVLVDDKDVMPDVRAELAHMKEFTNMVISGVWRGCTGKQITDVVNIGIGGSDLGPLMVTEALKPYGKGLHSHFVSNIDGTHLAEVLKKVNYETTLFIVASKTFTTQETITNATSAKTWLLEHSKEPESVAKHFVALSTNKEKVTEFGIDSTNMFGFWDWVGGRYSLWSAIGLSICLSIGFENFEQLLDGAHYMDNHFRTTPLEKNAPVILALLGVWYSNFFKAETHALLPYDQYLHRFAAYFQQGDMESNGKFVSKAGKAVKYSTGPIVWGEPGTNGQHAFYQLIHQGTRLIPCDFIAPAQTHNPIAGGKHHKILLSNFLAQTEALMAGKTVDEARAELSKAGLCGNELDNLLPHKVFVGNRPTNSIVVKKVSPFTLGALIALYEHKIFVQGIIWDINSFDQWGVELGKQLAKAIEPELDHCNEVSTHDSSTNGLINFIKANWK
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_BRUA1
Sequence: MGQKINPIGLRLGINRTWDSRWYANTGEYGKLLHEDVKIREFLTEELKQAAISKIVIERPHKKCRVTIHSARPGIIIGKKGADIEKLRKKLSEMTNADTSLNIVEVRKPEVDATLIAQSIAQQLERRVAFRRAMKRAVQSAMRLGAEGIRINCSGRLGGAEIARMEWYREGRVPLHTLRADIDYGTAEAKTAYGICGVKVWVFKGEILEHDPMASERRAVEGDNQGSSSNRRRENA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: RIHB_ECOBW
Sequence: MEKRKIILDCDPGHDDAIAIMMAAKHPAIDLLGITIVAGNQTLDKTLINGLNVCQKLEINVPVYAGMPQPIMRQQIVADNIHGETGLDGPVFEPLTRQAESTHAVKYIIDTLMASDGDITLVPVGPLSNIAVAMRMQPAILPKIREIVLMGGAYGTGNFTPSAEFNIFADPEAARVVFTSGVPLVMMGLDLTNQTVCTPDVIARMERAGGPAGELFSDIMNFTLKTQFENYGLAGGPVHDATCIGYLINPDGIKTQEMYVEVDVNSGPCYGRTVCDELGVLGKPANTKVGITIDTDWFWGLVEECVRGYIKTH
What is the function of this protein?
Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively.  Has a clear preference for cytidine over uridine.  Strictly specific for ribonucleosides.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihB, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihB subfamily.
Protein: SPOT_VIBCH
Sequence: MYLFDSLKDVAQEYLTEPQIEALRQSYVVARDAHEGQTRSSGEPYIIHPVAVARILAEMRLDLETLQAALLHDVIEDCDVTKEDLDAHFGSSVAELVDGVSKLDKLKFRDRKEAQAENFRKMVLAMVQDIRVILIKLADRTPNMRTLGALRPDKKRRIARETLEIYAPLAHRLGIHNIKTELEELGFEALYPNRYRVLKEVVKAARGNRKEMIQRIHSEIEGRLQEVGLPARVVGREKNLFSIYNKMKTKEQRFHTIMDIYAFRIVVDTADTCYRVLGQVHSLYKPRPARMKDYIAVPKANGYQSLHTSMVGPHGVPVEVQIRTEDMDQMADKGVAAHWSYKANSERGGTTAQIKAQRWMQSLLELQQSAGNSFEFIENVKSDLFPDEIYVFTPKGRIVELPMGATAVDFAYAVHTDIGNTCVGARVDRTPYPLSQSLKSGQTVEIISAPGARPNAAWLNYVVTSRARTKIRQVLKTMRREDSITLGRRLLNHALGEHSVNEIAPENISKVLSDLKIASMDDLLAAIGLGELMSIVIARRLLGNADELTEPSKSGGNKNKLPIRGAEGILLTFANCCHPIPDDHIIAHVSPGRGLVVHRETCPNVRGYQKEPDKYMAVEWTKDYDQEFITELKVDMHNRQGALAELTNVISKTGSNIHGLSTEERDGRLYTVTVLLTTKDRVHLAGIMRKIRTMPHALKVRRRKN
What is the function of this protein?
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
What are the official names of this protein?
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase, Penta-phosphate guanosine-3'-pyrophosphohydrolase, (ppGpp)ase.
What is the protein family that this protein belongs to?
Belongs to the RelA/SpoT family.
Protein: THIG_VIBCM
Sequence: MLKIADKTFQSRLFTGTGKFSNRHVMAEALAASGSELVTMALKRIDLAQRDDDILAPLLSMQMNLLPNTSGAKNAADAVYAAELAREALATNWLKLEIHPDPKYLMPDPIETLLAAEQLVKQGFIVLPYCHADPVLCKRLEEVGCAAVMPLGSPIGSNQGLASKTFLEIIIDQAKVPVIVDAGIGSPSDAAQAMELGADAVLVNTAIAAAHDPIAMAKAFKLAVEAGRMAYESGLPSRVKMATASSPLTGFLDFVS
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_ACIB5
Sequence: MPDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAAEIQAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGDEKAIDLVDAMVVAADDSYTDEEVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGQLIVELAKRYYEQNDASILPRSIATKAAFKNAMTLDIAMGGSTNTVLHLLAAANEAEVDFTMDDIDELSRRVPVLSKVAPAKQDVHMEDVHRAGGIMAILGELDRANLLDVSVPTVHEKTLKDALDKWDIIRTEDPDVYEFYRSSPGGVPTQVAFSQNRYYSTLDGDREKGVIRNAEHAFSKDGGLAVLYGNIALDGCIVKTAGVDESILKFTGSARVFESQDAAVEAILGNEIKAGDVVVIRYEGPRGGPGMQEMLYPTSYLKSKGLGKDCALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEDGDTIEIDIPNRTIHLNIDDATLAHRRTVQEAKGWHPKEERKRKVSKALKVYAMHTTSAAKGAVRVL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: HPPD_ZYMTR
Sequence: MAPGALLVTSQNGRTSPLYDSDGYVPAPAALVVGGEVNYRGYHHAEWWVGNAKQVAQFYITRMGFEPVAHKGLETGSRFFASHVVQNNGVRFVFTSPVRSSARQTLKAAPLADQARLDEMYDHLDKHGDGVKDVAFEVDDVLAVYENAVANGAESVSSPHTDSCDEGDVISAAIKTYGDTTHTFIQRTTYTGPFLPGYRSCTTVDSANKFLPPVNLEAIDHCVGNQDWDEMSDACDFYERCLGFHRFWSVDDKDICTEFSALKSIVMSSPNQVVKMPINEPAHGKKKSQIEEYVDFYNGPGVQHIALRTPNIIEAVSNLRSRGVEFISVPDTYYENMRLRLKAAGMKLEESFDIIQKLNILIDFDEGGYLLQLFTKPLMDRPTVFIEIIQRNNFDGFGAGNFKSLFEAIEREQDLRGNL
What are the official names of this protein?
4-hydroxyphenylpyruvate dioxygenase, 4HPPD, HPD, HPPDase.
What is the protein family that this protein belongs to?
Belongs to the 4HPPD family.
Protein: SYP_BURMA
Sequence: MKASRFFIGTLKEAPADAEIVSHKLMVRAGMIRRVAGGIYNYLPVGLRSIRKVEAIVREEMNRAGAIELLMPAVQPAELWQESGRWEQYGPELLRFKDRKQNEFVIGPTHEEVVTDIARNQIKSYRQMPVNFYQIQTKFRDEIRPRFGVMRGREFIMKDAYSFDKDHESLKESYKKMYDAYVRIFTRIGFEFRPVAADNGSIGGSGSHEFHVIADTGEDAIAYCPTSDFAANVEAAEALPLLASRAAPAEAMQKVATPGKAKCEAVAELMGIPLERTIKSIVLATDNEGAEPTIWLLMLRGDHDLNEIKTAKLPGLAGHRFATEAEIVEWFGTPPGYLGPIGTKKPVRVVADRTVANMSDFVVGANEVDYHIAGVNWGRDLPEPVVADIRNVKAGDPSPDGKGALDICRGIEVGHVFQLGTKYSDAMGATFIDESGKAQPMVMGCYGIGITRILGAAIEQNFDDKGIVWPEAIAPFEVVLCPMGYDRSDAVREAADKLYADLAAAGIDVILDDRGERPGVMFADWELIGVPHRLVIGERGLKDGKIEYQGRRDAEATLLPADSAAAAVAEKVRAALAR
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_CANAL
Sequence: MVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWKLQQKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMGRGLQKKATETQAAVDVTALEMVKWFDSNYHYVRPTFSHSTEFKLNTAAGIKPVDEFNEAKALGVQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYKELLQKLKEAGAEQVQIDEPVLVLDLPEAVQSKFKEAYDALVGADVPELILTTYFGDVRPNLKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGVVDGRNIWKTDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETKLDAVIKDWFSFATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSITNDPKVQERLTTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQTKDIRINRNKFAKGQITAEEYEAFINKEIETVVRFQEEIGLDVLVHGEPERNDMVQYFGEQLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKESVYAQSITSKPMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVNDLEGAGITVIQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENSTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDPNYIQEFSEYPNHIGLGLFDIHSPRIPSKQEFVSRIEEILKVYPASKFWVNPDCGLKTRGWPEVKESLTNMVEAAKEFRAKY
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: HELCL_DICDI
Sequence: MSEELARSKQYGYKENSNLVFYSERNRSELKEPKGEPETLWGRLRGEMGDRVNYSKPLELLEKMQNLKRKTIEKEGGDVNSSNDTYSTTKKVKNQNPLEKKSTNRKSNGNNNNEKPIDILSATESFQGLYKPKTKETRITYETLLTFIQRYVGDQPTEVVKGALDEILSILKDDTIRAPEKKIEISKLLKGLNDVSFAELTQLGKQITDFKDSELAKQQQQQQQQQSMDSLDDEQGVAVIIDEEEEEENLSDFEIRDDDDDDDDVDNNEVDDNNNNDSEAQDSEIQTKDENNNDDDENQKIKENNNNNNKSQKPDTKNTKDDKNNNSKLISPNEIDSFWIQRKISEFERDHDLSKQLAEKTLNILRQPNVRRCEQQLVDLFTIDKLDFLKLIINNKQTILYCTLLAKAENDQERKKIEDEMSSNPVTLSILNRLKGNEVTAATTEKTIEKTESNKKDVEMKQQQQQQQDEIKKPKKLLNLEELSFQQGSHLMTNKEFKFPKGSKREQYKGFEEIHVPARANPPFNPNERLISIEELPEWSRLPFEESGVKSLNRVQSKLFDCAFKTDNNLLLSAPTSSGKTNVAMLTILHEIGKNRDRDSGKIRLDAFKIVYIAPMKSLVQEMVGNFSKRLKSYGIVVNELTGDQSLTNKQISETQIIVTTPEKWDIITRKSGDRAYTQLVKLIIIDEIHLLHDERGPVLECIVARTLRMIESTQQMVRLVGLSATLPNYEDVATFLRVEPDGVFYFDSSYRPIPLEQQYIGISDRGIKQLQRCNDITFTKVSERVGDHQILIFVHSRRETAKTGKDLRDRAVEDQSIDRYIRDPASREILRATASKQIQNAELKDLLPYGIGIHHAGLSRSDRSLVEDLFGDNRIQVLISTATLAWGVNLPAHTVIIKGTQIYNPEKGWCELSPLDVTQMLGRAGRPPFDKEGEGIIITSQHELQFYLSLLNTQLSIESQFISRIADNLNAEIVLGSIQTVRDAVNWLGYTYLYICMIRNPPLYEISYDDFEKDPLLEQRRLDLVHSAATILEKNSLIKYDRKSGKLQSTELGKVASHYYITNSSMSIYQEHLKPSMSDIELLRVFSLSSEFKNVVVREGEKFELEKLLERVPIPIKENIEEPSSKINVLLQTYISNLKLDGFALVVDMFYIAQSASRITRALFEIVLKKGWAQLAKKILNLAKMIDSKMWSSQSPLRQFHKISPKVLNQLERRGIPIEDLYEYNSQQLGNAIQNPSEGKQLFDLIHNFPKLDLTAHVQPILHGLLRVELSITPDFQYDERYHNNSIGWWIIVEDVDGERILYFEYFSLKKKMVNGEDQLVSFTVPLSQPLPPQYYVRVISDHWIGAEYSLPISFQHLILPEKYPPCRPLLDLQPLPIQVLKDPKAESIFKPTFSIFNAIQTQVFNCMYQSNDNAFISAPTNSGKTVCAEIALIRCFKQNPKAKVVYLAPMQDLASVRLKDWSNKFGVKSPFGLVVSDLTGDAVTDNKILDRSNIIVTNCEKWDILSRKWKQRKALQSINLLIVDELHLIGGEYGPTMEIVVSRMRYISTQTGNALRVIALSSSIANARDLVLWIGATPQTCYNFHPNVRPIPVEYQIQGFEFPHFNARMLAMTKPTVYEVAKNKNQQSIVFVPTRKLSRSLAADIIANVSSFEDTLTKPYLVCEEHVLTPYLEDVDSFALKQSLQMGVAFYHDGLTERERRVVEILFRSGSIRVLIATHSVAWLLDNVFAQLVVIMGTQLYQGKDIRYIDYPINDILQMIGRAGKQEGGGVISNKVAKVLLLCHAPKKEYYKMFLNEPLPVESHLDHCLHDQFNSEIVTKTITKKQDALDYLTWTFLYRRLNQNPNYYNLSGVSHLHLSEHLSELVENTLVELEQSNCITIQDDQDKVSPLNLGIIASYYYLKYQTIELFGSSLKSTTRRRGIMDIISNAPEFNSLPIRHREDQILMKLASHLPQKIDKPNYQEISTKVNVLLQCHFSRESISADLYQDQKFILENATRLLQAIVDVISSNSWLQPAIAAMELSQMITQAMWDSDSVFKQLPHMNKRRIDAITSQGIESVFDLMSLDDNSRIQLLDLSQQESNDLVQSFMKYPDIDISYQVQDEDDLHADSIMTVEMVIERDLGDDEENPIEINDSINVVSAPYYPKEKICGWWALIGDSKNNHLLAIKRITFLKKTKVKFEFPTPAVGKHQLSLYLFSDSYNGCDQEHELNINILPAEIEDEDEDEEEDNEMDE
What are the official names of this protein?
Activating signal cointegrator 1 complex subunit 3-like.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
Protein: ATPE1_CERS4
Sequence: MAGTLQFDIVSPERRLASFAATEVQVPGTDGDMTAMEGHAPTITTLRPGILRAHGPSGVQAYAVTGGFAEINATSISVLAEKAVAVEELTGTVLDEFIAEARELASVALPEDRDMAERTLNDMLALKASSGH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain 1, ATP synthase F1 sector epsilon subunit 1, F-ATPase epsilon subunit 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HIS7_XYLFM
Sequence: MTPIVFIDRDGTLIEEPPDFQIDAYEKLRLVNGVIPALLKLRDAGYHFVIVTNQDGLGSPTYPQASFDGPNALMLQIFSSQGIVFRDVLIDRSWPADNAPTRKPGIGLMVAYLQDRDIDWARSAMVGDRPTDLQFAENLNIRGFQLRTPQFGGDWDWDGIAHTLADAPRRAVVQRHTKETNIRVEIDLDGAPQARITTGLPFFNHMLEQIAKHAGISLQISAVGDLHIDEHHTIEDTGLALGQAVRQALGDKRGIGRYGFDPPQLPWQVSGAAAHGGFTLPMDETQASAVLDFSGRPYFVFEGTFVRERVGDMPTELVPHFFRSLCDASGMNLHLSVHGDNDHHKVEACFKALARALRQALQRHGHVLPSTKGAL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROK_PELTS
Sequence: MKNIVLIGFMGTGKTAVGRRLAGRLKREFIDTDAEIEKVTGKTVAQIFARDGQIRFRSEEALLVRKLAGKENLVISTGGGMVLNPENVRLLKENGVLIALTADPEVICRRVKNKKNRPLLMRGDLRENIKALLKEREGVYDVAEHKVDTGSMSLDQAVENIIHFLKEHNYIE
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_STACT
Sequence: MSKITEQIEEIIQPVLDDLNFELVEIEFTKEGKDHFLRISIDKEGGVDLNDCTLASEKISEVMNEEDPIEQMYYLDVASPGAERPIKTDKALHDAVEQPVFVSLYAPIDGSKEWLGVLQSVTDDHIVIKAQVKEKKKEVEIPRNKIAKARHAVLI
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZDH16_HUMAN
Sequence: MRGQRSLLLGPARLCLRLLLLLGYRRRCPPLLRGLVQRWRYGKVCLRSLLYNSFGGSDTAVDAAFEPVYWLVDNVIRWFGVVFVVLVIVLTGSIVAIAYLCVLPLILRTYSVPRLCWHFFYSHWNLILIVFHYYQAITTPPGYPPQGRNDIATVSICKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFREAYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGALTVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDNWKVFLGVDTGRHWLTRVLLPSSHLPHGNGMSWEPPPWVTAHSASVMAV
What is the function of this protein?
Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475).  Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity).  Also required for eye development (By similarity).  Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475).  May play a role in DNA damage response (By similarity).  May be involved in apoptosis regulation (By similarity).  Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).
What are the official names of this protein?
Palmitoyltransferase ZDHHC16, Abl-philin 2, Zinc finger DHHC domain-containing protein 16, DHHC-16.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DEPD7_HUMAN
Sequence: MATVQEKAAALNLSALHSPAHRPPGFSVAQKPFGATYVWSSIINTLQTQVEVKKRRHRLKRHNDCFVGSEAVDVIFSHLIQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYRFTTIPNQDSQLGKENKLYSPARYADALFKSSDIRSASLEDLWENLSLKPANSPHVNISATLSPQVINEVWQEETIGRLLQLVDLPLLDSLLKQQEAVPKIPQPKRQSTMVNSSNYLDRGILKAYSDSQEDEWLSAAIDCLEYLPDQMVVEISRSFPEQPDRTDLVKELLFDAIGRYYSSREPLLNHLSDVHNGIAELLVNGKTEIALEATQLLLKLLDFQNREEFRRLLYFMAVAANPSEFKLQKESDNRMVVKRIFSKAIVDNKNLSKGKTDLLVLFLMDHQKDVFKIPGTLHKIVSVKLMAIQNGRDPNRDAGYIYCQRIDQRDYSNNTEKTTKDELLNLLKTLDEDSKLSAKEKKKLLGQFYKCHPDIFIEHFGD
What are the official names of this protein?
DEP domain-containing protein 7, Protein TR2/D15.
What is the protein family that this protein belongs to?
Belongs to the DEPDC7 family.
Protein: AMI_LISMG
Sequence: MKKLVKSAVVFAGLVFIGTSATMITEKASAASTDPVQKVDGQATYIPKGVRDGTATEEHDGFEDGTNSVLQQVPLLRATTGYPDVNAYIKSNKFSTAKIEKQLKSQFPKFNYRNGYGKPEGIVIHETANNSSTITGEINYMSTNYNNAFVHAFVDKSRIIQIHPTENGVWGAGQYANARFIQVELVRSKTFDEFARSINNYAYYAAYLLDQYNLPVDSAHSDGKGTVWSHDAVTRYLGGTTHTDPVAYFNQWGYNFNNFVSLINEKYKAMQVNYEKIEYDKAITAYSRVKTATGNSVWTKPNKTEGAKLVNPLSSYSGKNLRIIREAKTSGGTIWYQFSVGGKTIGWVDSKALNTFYTPSMEKTITGTRYVLPSKQTVHYYGLPVEDSAIDRGPLSKFNGQALTLQREATIEGQLWYRVKDLGWVKAVNLTTTKYDLIEYDKAITAYSRVKTAAGNYVWSKPNKTEGAKQGSALSTYSGKNMRIIREAKTSSGTIWYQFSIDGKTIGWVDTKALNTFYTPSMEKNLTATRYVAPGQETQHYYGLPVADSAIDRGPLSKFAGQTLTVQREATIEGQLWYRVKDLGWTKASTLTATQYDKLEYDKAITAYSRVKTATGNSVWTKPYRTSGYKLVNPLSSYAGKNLRIIREAKTSSGIWYQFSVGGKTIGWVDSKALNTFYTPSMEKTITGTRYVLPSKQTVHYYGLPVEDSAIDRGPLSKFNGQALTLQREATIEGQLWYRVKDLGWVKAANLTTTKYDTLSYDKAITAYSRVKTATGNSVWTKPNKIEGAQKISALSTYSGKNMRILREAKTSSGTIWYQFSVGGKTIGWVETKALNTFYTPSMEKNLTATRYVLTSKKNEHYYGLPVVDSAIDRGPLSKFSGKTLTVQREATIEGQLWYRVKDLGWTKAANLSAKKQ
What is the function of this protein?
A bacteriolysin able to lyse both L. monocytogenes and S. aureus.
What are the official names of this protein?
Protein Ami, Autolysin.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
What are the subcellular locations of this protein?
Cell surface. Cell membrane. Note=Anchored by its GW repeats to the cell surface.
Protein: SUV3_CHICK
Sequence: MRRCAWPLLRLSSRVGLALRHGGAVRLRQAAASSSSSSSGGGGLRAPDTSLFVPVPLKPVEGAAEEDVGAELTRPLDKGEVLKNLNKFYKRKEIQRLGTENGLDARLFHQAFISFRKYIMESSSVSADLHIILNDICCGAGHVDDLFPFFLRHAKQIFPMLDCMDDLRKISDLRLPPNWYPEARAIQRKIIFHAGPTNSGKTYHAIQRFLSAKSGIYCGPLKLLAHEIFQKSNAANVPCDLVTGEERVYASEDAKQASHIACTIEMCSTNTPYEVAVIDEIQMIRDPARGWAWTRALLGLCAEEIHVCGEGAAIDLVTELMYTTGEEVEVRNYKRLTPLTVLDYALESLDNLQPGDCIVCFSKNDIYSVSRQIEARGLECAVIYGSLPPGTKLEQAKKFNDPNDPCKILVATDAIGMGLNLCIKRIIFNSIVKPTVNEKGEKEIDSITTSQALQIAGRAGRFGSSFKQGEVTAMHRDDLLQLKEILSEAVPPVKAAGLHPTPEQIEMFAYHLPDATLSNLIDIFVSLSQVDGLYFVCNIDDFKFLADMIQHIPLNLRSRYVFCTAPLNRKEPFVCTTLLKFARQFSRNEPLTFDWLCRHTKWPLAPPKNIKELVHLEAVHDVFDLYLWLSYRFMDMFPDAALVRDIQKKLDDIIQIGVCNITKLIRASQSGAAPGAAEVMSEGFPLSRTKRDARTVSDHRDAKSAEPLSIALEVPGERRAKSLRTYRSATRQEDLKSHGRGSLANRLLREGLLTQEMLRQLESEWQDQHRSGRYGLASKRNDQSSSKEMGKKKK
What is the function of this protein?
Major helicase player in mitochondrial RNA metabolism.  Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner.  ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction.  Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates.  Also implicated in recombination and chromatin maintenance pathways.  May protect cells from apoptosis.  Associates with mitochondrial DNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase SUPV3L1, mitochondrial, Suppressor of var1 3-like protein 1, SUV3-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
Protein: PNP_PROM9
Sequence: MEGQNKSITFDGREIRLTTGLYAPQANGSVMIECGDTSLLVTATKTTKKEVADFLPLICDYEEKLYAAGRIPGGFMRREGRPPERATLISRLIDRPMRPLFPSWMRDEIQIVASCLSLDERVPADVLAVTGASIATLLGEIPFHGPMAAVRVGLIGDDFILNPSYREIEKGDLDIVVAGSPDGIVMIEAGANQLSEQDTIEAIDFGYESVTELIKSQVDLLKDLGIKQVKSSAPEEDNTLPSYLEKNCTKGIELVLKKFDQSKDERDLELEKIKVDTQAKIESLKDDNELKVLLSENDKLLSSDFKKLTKKLMRSQIINDGKRVDGRELDEVRKISASAGILPKRVHGSALFQRGLTQVLSTTTLGTPSDAQEMDDLNPSTEKTYLHHYNFPPFSVGETRPMRTPGRREIGHGALAERAIIPVLPGKETFPYVLRVVSEVLSSNGSTSMGSVCGSTLSLLDAGVPLKALVSGTAMGLIKEGKEIRILTDIQGIEDFLGDMDFKVAGTEKGITALQMDMKITGLSVSVISDAIKKARPARLHILEKMQEAIDKPQESLSPHAPRLLSFRIDPELIGTVIGPGGRTIKGITERTNTKIDIEDGGIVTIASHDGAAAEEAQKIIEGLTRKVHEGEIFTGVVTRIIPIGAFVEILPGKEGMVHISQLSEARVERVEDVVRQGDEVTVRVREIDSRGRINLTLRGVSQNSGMSYPEPTPTPVAPLN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CPSF5_DANRE
Sequence: MSVVPPNRSSTGWPRGVNQFGNKYITQATKPLTLERTINLYPLTNYTFGTKEPLYEKDSSVAARFQRMREEFEKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLMTEILGRQDGVKQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN
What is the function of this protein?
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs.  CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals).  Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.  The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.  Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing.  The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA.  Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function.  Binds to chromatin.  Binds to, but does not hydrolyze mono- and di-adenosine nucleotides.
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 5, Nudix hydrolase 21.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. CPSF5 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.