PharMolix/UniProtQA huggingface dataset:
Protein: RBL_VARPS
Sequence: MGNMNEAIQITDAKKRYSAGVLKYAQMGYWDGDYVPKDTDILALFRITPQEGVDAIEAAAAVAGESSTATWTVVWTDRLTACDMYRAKAYKVEPVPNNPGQYFCYVAYDLSLFEEGSITNVTASIIGNVFSFKPLKAARLEDMKFPVAYVKTFPGPPTGIVVERERLDKFGRPLLGATTKPKLGLSGRNYGRVVYEGLRGGLDFMKDDENINSQPFMHWRDRFLFVMDAVNKASAATGEVKGSYLNVTAGTMEEMYRRAQFAKELGSVIVMVDLVIGYTAIQSMSNWCRQNDMILHLHRAGHGTYTRQKNHGVSFRVIAKWMRLAGVDHIHAGTAVGKLEGDPMTVQGYYNVCRDTHTKVDLPRGIYFDQDWGALRKVMPVASGGIHAGQMHQLLDLFGDDVVLQFGGGTIGHPQGIQAGATANRVALEAMVLARNEGRDIANEGPQILRDAAKWCTPLAAALDTWGEISFNYASTDTSDYVPTPSVA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: RBE21_LITRU
Sequence: IEFFA
What is the function of this protein?
Shows neither neuropeptide activity nor antibiotic activity.
What are the official names of this protein?
Rubellidin-2.1.
What are the subcellular locations of this protein?
Secreted.
Protein: PHAR2_HUMAN
Sequence: MDNAVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGASHKGDEVPPIKKNTKAPGKQAPVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKFKSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLYSGTGLSVNRENAKCFTTKEELGKTVPQLLTPGLMGESSESFSASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRRDTLAIKLGNRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTEMEVHEESRQFTRFHRP
What are the official names of this protein?
Phosphatase and actin regulator 2.
What is the protein family that this protein belongs to?
Belongs to the phosphatase and actin regulator family.
What are the subcellular locations of this protein?
[Isoform 2]: Membrane; Lipid-anchor. SUBCELLULAR LOCATION: [Isoform 4]: Membrane; Lipid-anchor.
Protein: MEIS2_HUMAN
Sequence: MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ
What is the function of this protein?
Involved in transcriptional regulation.  Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex.  Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding.  Probably in complex with PBX1, is involved in transcriptional regulation by KLF4.  Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain.  May be involved in regulation of myeloid differentiation.  Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.
What are the official names of this protein?
Homeobox protein Meis2, Meis1-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the TALE/MEIS homeobox family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region.
Protein: H1_TETTS
Sequence: MAPRSSTSKSATREKKDHKKAPIKKAIAKKDTKPTPTKGKAASASTTPVKKDVTPVKADTKKKIHKTKTMKETVSDAKKTVHAAAGDKKLSKKRPAKEAAKKAINPGKKAAAQPKSTKKEVKKDNKTAKKETKKDHKPAKKEAKKETKPAKKDAKKSSKPAKKN
What is the function of this protein?
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
What are the official names of this protein?
Histone H1.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Macronuclei.
Protein: HIS6_MYCLB
Sequence: MYSGNGLAVRVIPCLDVYCGRVVKGVNFKNLRDAGDLVELAAAYDAEGADELAFLDVTASSSGRATMLEVVRCTAEQVFIPLMVGGGVRTVADVDVLLRAGADKVAVNTAAIARPELLADMAGQFGSQCIVLSVDARTVPTGSARTPSGWEATTHGGYRGTGIDAVEWAARGADLGVGEILLNSMDADGTKAGFDLAMLRAVRAAVTVPVIASGGAGAIEHFVPAVTAGADAVLAASVFHFRELTIGQVKDAMAAAGIAVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHA_SALTY
Sequence: MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNTHEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNLKNHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMALRAGVPVQDMEMWQFHPTGIAGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTGQALTVNEQGEDVVIPGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGLHLQESIAEQGVLRDASESDVEGSLERLNRWNNNRNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQLKVIRERLKNARLDDTSSEFNTQRVECLELDNLMETAYATAVSANFRTESRGAHSRFDFPERDDANWLCHTLYQPQTESMTRRSVNMEPKLRPAFPPKIRTY
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.
What are the official names of this protein?
Succinate dehydrogenase flavoprotein subunit.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TRM5_GIAIC
Sequence: MSHQRPEIFDNFAGAQVMTVDGEPQRDLNQARRIVLEMKEPLCRIPEDLRSLLSVTISVYCIETPSALVSTIIKNMPPEASIALVTGCRFLAVRDGPRGKTVTVLSTAFLSGLDESVTQQLFIHADTLLLTPEARSRISLLQDIIEDPPTSFETVGHIAHYNLREAHLPYRYFIGAVTCEKEPAITTVITKIDTVQSQYRTYNFELIGGVPRYDVKLVQDGITYSFNYTKVYWNSRLSHEHLSLAQHINQTICPNDLVLDGTCGIGPHALLLAKRFNFTNLICNDLNPDAYKSLKMNVRINKAENAITCFNEDVSSLLRRLLPETNLKAVIFSLPELSINLLQAMKGVPDIYCFLECFTRAPPHLAYYDLLLRCSESLLDTKVCTGIQQALSDIEKVAENKELIDLLIACYETFEVKEIRTVSTNKFMYRVTLKINEQKETVKVLKK
What is the function of this protein?
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs.  Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside.  This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
What are the official names of this protein?
tRNA (guanine(37)-N1)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix. Nucleus. Cytoplasm. Note=Predominantly in the mitochondria and in the nucleus.
Protein: RL16_CUTAK
Sequence: MLIPRRVKYRKQHHPKRTGAAKGGTQLAFGDYGIQATEGGYLTNRQIEAARIAMTRYIKRGGKVWINVYPDRPMTKHPAESRMGSGKGTPEWWIANIKPGRVLFELSGVPEDVAREAMRLAIHKLPMKARFISREGGDN
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: Y1488_DESVM
Sequence: MDIAAFFAAEVKPALGCTEPGAVALAAATAARHLPAPPERIHLRLSANIYKNGQSVGIPGAQGLRGNMLASALGALAGDADMGLQALAAVTADDVAAARALTERGAVTQEIVQDVPTVYAEAELYRPGHLVVAVVAGRHDRVAEVRHNGQVVYRAEDALGGDSLPPYMADLQRAAFGDLWNWADGIDADLARDLLRGAEMNLAVAEQGLANPWGLAVGHTLGMALRGGDCRNDSASDARAPGSCVPDACGPDISARVKATTAAAADVRMAGANQPVMSSAGSGNHGLTAIIPPALAARAWGRSDAELARALALSHLVTGAVKARTGRLTPLCGCAVAAGAGAAAALVRLADGTPAQAEQAVALVFSSVMGMICDGAKGGCALKVGTAAAEAWSAAQLALHGPGMTGAEGIVSPDFRASLRSLGEVSSLGFAAVDVAIIRLLERGVQ
What are the official names of this protein?
UPF0597 protein DvMF_1488.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: RS7_BURCM
Sequence: MPRRREVPKREVLPDPKFGNVDVAKFMNMLMLSGKKSVAERIVYGAFEQIQTKGGKDPLEVFTVALNNVKPVVEVKSRRVGGANYQVPVEVRPSRRMALAMRWLREAAKKRSEKSMALRLAGELSEAAEGRGGAMKKRDEVHRMAEANRAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SYG_MYCBO
Sequence: MHHPVAPVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVELKENIKRQWWRSVVTGRDDVVGIDSSIILPREVWVASGHVDVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPETGEPGQWTQPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPATAKEWHQYWIDNRLQWYIDLGIRRENLRLWEHPKDKLSHYSDRTVDIEYKFGFMGNPWGELEGVANRTDFDLSTHARHSGVDLSFYDQINDVRYTPYVIEPAAGLTRSFMAFLIDAYTEDEAPNTKGGMDKRTVLRLDPRLAPVKAAVLPLSRHADLSPKARDLGAELRKCWNIDFDDAGAIGRRYRRQDEVGTPFCVTVDFDSLQDNAVTVRERDAMTQDRVAMSSVADYLAVRLKGS
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_MYCA1
Sequence: MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKYPDLNESRAFDQIDNAPEERQRGITINISHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADMVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKALEGDAKWVESVEQLMEAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIRPSSTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGIKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVKLIQPVAMDEGLRFAIREGGRTVGAGRVVKIIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_HELP2
Sequence: MKIFGTDGVRGKAGVKLTPMFVMRLGVAAGLYFKKHSKTNKILIGKDTRKSGYMVENALVSALTSIGYNVIQIGPMPTPAIAFLTEDMRCDAGIMISASHNPFEDNGIKFFNSYGYKLKEEEERAIEEIFHDERLLHSSYKVGESIGSAKRIDDVIGRYIVHLKHSFPKHLNLQSLRIVLDTANGAAYKVAPVVFSELGADVLVINDEPNGCNINEQCGALHPNQLSQEVKKYRADLGFAFDGDADRLVVVDNLGNIVHGDKLLGVLGVYQKSKNALSSQAIVATSMSNLALKEYLKSQDLELKHCAIGDKFVSECMRLNKANFGGEQSGHIIFSDYAKTGDGLVCALQVSALVLESKQVSSVALNPFELYPQNLVNLNVQKKPPLESLKGYSALLKELDQLEIRHLIRYSGTENKLRILLEAKDEKLLESKMQELKEFFEGHLC
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: GLMU_PSYCK
Sequence: MTSSLSVIILAAGKGTRMQSAKPKVLQTLAGKSLLGHVLDTCHQLTVDDTIIVHGFGGEQVQDHIDQQYAHLPITWVAQTEQLGTGHAVKVTLSELPKDGQSLILYGDVPLVSCQTLATLQDANTDGMSMLTLTVDNPFGLGRIKRDKDGNIEAIIEQKDANSDEQQIQEINSGIYCVDNALLHKFLPKLSNDNAQQEYYLTDIVKMAVADGITIAAIEPEHTFEIEGVNNRQQLASLERTWQGKLVADLQEAGVQFADPTRVDIRGTLSAGQDVFVDVGVVFEGDCVLGDNVYIEAGCVIKNAQIGNACHIKPYCVIDSAEVGAGVDIGPFAHLRPETILSDNSKVGNFVEIKKSTIGDGSKVNHLSYIGDATIGTGVNVGAGVITCNYDGVNKSQTIIDDNAFIGSNSSLVAPVKIGDTATVAAGSVITKNVDAHALAFGRARQTQKNDFKRPTKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDP_STAAM
Sequence: MRMIDIIEKKRDGHTLTTEEINFFIDGYVKGDIPDYQASSLAMAIYFQDMNDDERAALTMAMVNSGDMIDLSDIKGVKVDKHSTGGVGDTTTLVLAPLVAAVDVPVAKMSGRGLGHTGGTIDKLEAIDGFHVEIDEATFVKLVNENKVAVVGQSGNLTPADKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGSGAFMKTLEDAEALAHAMVRIGNNVGRNTMAIISDMNQPLGRAIGNALELQEAIDTLKGQGPKDLTELVLTLGSQMVVLANKAETLEEARALLIEAINSGAALEKFKTFIKNQGGDETVIDHPERLPQAQYQIEYKAKKSGYVTELVSNDIGVASMMLGAGRLTKEDDIDLAVGIVLNKKIGDKVEEGESLLTIHSNRQDVDDVVKKLDSSITIADHVVSPTLIHKIITE
What is the function of this protein?
Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
What are the official names of this protein?
Pyrimidine-nucleoside phosphorylase, PYNP, Py-NPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: RL14_ONYPE
Sequence: MIQRESRLVVVDNSGAKEVLVIGILGGTRRSHVNIGDIVLVTVKSGSGTVKKHDVLKAVIVRTKKGLRRKNGSYIKFDDNAVVLLKEDLNIIGTRIFGPVVRELSDKKFSKIVSLAQLVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RNZ_CLOPE
Sequence: MLNVTLLGTGGGMPMPNRFLSSVVMNFNGRKILLDCGEGTQVSMRVNGTGFKSIDIICISHLHGDHIYGLPGLLSTIGNSGRVEDIYIIGPNGIKEVIEGFLITLPYLPYKLNILEDASNLEFMVKKEKIELVELNEKISSDLTIETLGLDHSSPCLGYSFNIRRGRKFNVEKALMNKVPKELWSKLQRNEEVSLNGVKYYSYMVLGDERKGIKLSYTTDTRPTEDIPGFIKESDLYICEGTYGSEEDMHKAIKNKHMTFKEAANLAKKGQVKELLLTHFSPSINDPKEFINNAREVFENLHAGSDGEERVLNFKE
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: KCMA1_RABIT
Sequence: MANGGGGGGGSSGGGGGGGGGGSGLRMSSNIHASHLSLDASSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKAKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPNSSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
What is the function of this protein?
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+).  It is also activated by the concentration of cytosolic Mg(2+).  Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane.  It therefore contributes to repolarization of the membrane potential.  Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity.  In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential.  In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map.  Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits.  Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
What are the official names of this protein?
Calcium-activated potassium channel subunit alpha-1, BK channel, BKCA alpha, Calcium-activated potassium channel, subfamily M subunit alpha-1, K(VCA)alpha, KCa1.1, Maxi K channel, MaxiK, Slo-alpha, Slo1, Slowpoke homolog, RbSlo, Slo homolog.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 4]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Cytoplasmic, and probably remains in the endoplasmic reticulum.
Protein: SYI_ECOHS
Sequence: MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYANGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQEYGKPGEKFTAAEFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHKGAKPVHWCVDCRSALAEAEVEYYDKTSLSIDVAFQAVDQDALKAKFAVSNVNGPISLVIWTTTPWTLPANRAISIAPDFDYALVQIDGQAVILAKDLVESVMQRIGVTDYTILGTVKGAELELLRFTHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDYVIGQKYGLETANPVGPDGTYLPGTYPTLDGVNVFKANDIVVALLQEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQWFVSMDQKGLRAQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHKDTEELHPRTLELMEEVAKRVEVDGIQAWWDLDAKEILGDEADQYVKVPDTLDVWFDSGSTHSSVVDVRPEFAGHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADSYRRIRNTARFLLANLNGFDPAKDMVKPEEMVVLDRWAVGCAKAAQEDILKAYEAYDFHEVVQRLMRFCSVEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTADEVWGYLPGEREKYVFTGEWYEGLFGLADSEAMNDAFWDELLKVRGEVNKVIEQARADKKVGGSLEAAVTLYAEPELSAKLTALGDELRFVLLTSGATVADYNDAPADAQQSEVLKGLKVALSKAEGEKCPRCWHYTQDVGKVAEHAEICGRCVSNVAGDGEKRKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUT_BURTA
Sequence: MKLDLKILDARMRDYLPKYATTGSAGLDLRACLDAPVTLKPGDTALVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGNLVGLIDSDYQGELMISTWNRGQTEFVLNPFERLAQLVIVPVVQATFNIVGDFAQSDRGAGGFGSTGRH
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: OX2R_PIG
Sequence: MSGTKLEDSPPCRNWSSAPELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTMLPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQQTKSRISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLARGRTSTESRKSLTTQISNFDNISKLSEQVLLTSMSTLPAANGAGQLQNW
What is the function of this protein?
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.  Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
What are the official names of this protein?
Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R, Hypocretin receptor type 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLRX2_BOVIN
Sequence: MYWRRAALVGTRLIPVRSSSAGRLEGPAGISGSGMGNSTSSSLGNAATAPVNQIQETISNNCVVIFSKTSCSYCTMAKNLFHDMNVNYKVVELDMLEYGSQFQDALHKMTGERTVPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCHLKNSKREEL
What is the function of this protein?
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress.  Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.  Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides.  Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.  Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex.  Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release (By similarity).
What are the official names of this protein?
Glutaredoxin-2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: G3P_SULIL
Sequence: MISVAVNGYGTIGKRVADAILKQPDMRLVGVAKTSPNYEAFIAHRKGIKIYVPQQSIKKFEEAGIPVAGTIEDLVKASDIVVDTTPNGVGAQYKPIYQQFQRNAIFQGGEKAEVADISFSALCNYDEALGKKYIRVVSCNTTALLRTICTINKVTKVEKVRATIVRRAADQKEVKKGPINSLVPDPATVPSHHAKDVNSVIKNLDIVTMAVIAPTTLMHMHFINITLKDKVEKKDVLSVLENTPRIVLISSKYDAEATAELVEVARDLKRERNDIPEVMVFDDSVYVKDNEVMLMYAVHQESIVVPENVDAIRASTRLMSAEDSIRITNESLGILKGYLI
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.