PharMolix/UniProtQA huggingface dataset:
Protein: PHA4_CAEEL
Sequence: MTSPSSDEDIIDIRVIKEEPESEPDSEAEPATTTNSTDSEDSVEQENKKLLETEKNRKREQKHKMLPNGTTSGTSDTGNQVPATSSAASSVDYTAMNAQDYLPTYSNTTLNYQPYQYQTAANGLLNYNNYSQYATANQLGSNYISPANFMQGGGISPLGFTTGTTGATTAAASVATSSASAVIGRSNGRSSSTVAASPADRSYSGVSGGQGQELTIQEFETVTEKIRRHGTYGQSKPPYSYISLITMAIQKSNSRQLTLSEIYNWIMDLFPYYQNNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSFWTLHEHCGNMFENGCYLRRQKRFKVKEREPSRKKRNANSQQLHQQQHIPKMEIKEEDPTSITTTSSLGAYSLIPQISTKKEIKEELKAVQDATAAAANLGLIDPSGTPSAVNHSQPTSVISSVGTLGTTQAQMTLNGQYASPYLYSSDFATILPQSQNFLNNTLYNTTSSYPGIDYTNGVYQNTLYSSTNPNSAANL
What is the function of this protein?
Acts as a transcription factor required for formation of the pharyngeal primordium (PubMed:7607089, PubMed:18448117).  Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression (PubMed:18448117).  Becomes associated with pharyngeal target promoters by the 8E cell stage, playing a role in inducing large-scale chromatin decompaction, prior to the activation of transcription (PubMed:20714352).  Binding with target sequences in pharyngeal cells may be repressed by the nuclear lamina protein emr-1 (PubMed:20714352).  Activates a wide array of pharyngeal genes including ceh-22, pax-1 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate (PubMed:11823633, PubMed:20714352, PubMed:9584117, PubMed:14738885).  Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development.  Acts in the regulation of diet-restriction-mediated longevity by increasing expression of sod-1, sod-2, sod-4 and sod-5 but not sod-3 (PubMed:17476212).  Positively regulates the expression of the transcription factor hlh-6 in the pharyngeal gland (PubMed:17049341).  May regulate gene expression in the intestine (PubMed:18448117).
What are the official names of this protein?
Defective pharyngeal development protein 4, Ce-fkh-1, Fork head-HNF-3 homolog.
What are the subcellular locations of this protein?
Nucleus. Note=Present in nuclei of all cells of larval and adult pharynx but variable in neuronal nuclei.
Protein: TCPW_BOVIN
Sequence: MAAIKAINSKAEVARAQAALAVNICAARGLQDVLRTNLGPKGTMKMLVSGAGDVKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEIAKIKALEVLEQVKIKKEMKREIHLDVARTSLQTKVHPQLADVLTEAVVDSVLAIRRPNYPIDLFMVEIMEMKHKSETDTKLIKGLVLDHGARHPDMKKRVDDAFILTCNVSLEYEKTEVSSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKDKVCAQSNKGFVVINQKGIDPFSLDALAKHGILALRRAKRRNMERLSLACGGVAVNSVEDLSVDCLGHAGLVYEYTLGEEKYTFIEDCINPRSVTLLVKGPNKHTLTQIKDAVRDGLRAIKNAIEDGCVVPGAGAVEVVIAEALVTYKHTIQGRARLGVQAFADALLIIPKVLAQNSGYDLQETLVKVQAEHSNSKQPVGIDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.
What are the official names of this protein?
T-complex protein 1 subunit zeta-2, TCP-1-zeta-2, CCT-zeta-2.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL30_BURCM
Sequence: MSEKTVKVQLVKSLIGTRESHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: CA140_HUMAN
Sequence: MTQNSSSLGDRIITPYTPPRSQPMNKHLFVSLSTLFQTTELDFANKKSCFLCLPLRADGFPEMPHSPAQTERMQKLAKDPPHARSEDVPDHLFFVDTAGLREIVCFCGVLSLRTSEGLMRKETA
What are the official names of this protein?
Putative uncharacterized protein C1orf140.
Protein: CDC27_MOUSE
Sequence: MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDLVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKLTSLQNFSSCLPNTCTTLVSNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSTVISPDNVPLGPGTAILSKQVQNKPKTGRSLLGGPTALSPLTPSFGILPLETPSPGDGSYLQNYTNTPSVIDVAPTGAPTKKSVARMGQTGTKSVFSQSGNSREVTPVLVAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGLTQPSINDSLEITKLDSSIISEGKITTVTPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYSTGWVLCQIGRAYFELSEYMQAERIFSEVRRIESFRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF
What is the function of this protein?
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.  The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
What are the official names of this protein?
Cell division cycle protein 27 homolog.
What is the protein family that this protein belongs to?
Belongs to the APC3/CDC27 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle.
Protein: Y2923_MYCTO
Sequence: MTQLWVERTGTRRYIGRSTRGAQVLVGSEDVDGVFTPGELLKIALAACSGMASDQPLARRLGDDYQAVVKVSGAADRDQERYPLIEETMELDLSGLTEDEKERLLVVINRAVELACTVGRTLKSGTTVNLEVVDVGA
What are the official names of this protein?
Uncharacterized protein MT2992.
Protein: SRTF_STRPY
Sequence: MLKIQNLKKSYGKRTILNNVNMNIPKGKVYALIGPNGAGKSTIMKILTGLVSKTSGSIIFEGREWSRRDLRKIGSIIEEPPLYKNLSAYDNMKVVTTMLGVSESTILPLLNKVGLGNIDKRPVKQFSLGMKQRLGIAISLINSPKLLILDEPTNGLDPIGIQELREIIESFKSEGMTIMISSHILSEVEHLADFIGFIYEGKIILEKEYDGSENLEELFNNQILFEKRR
What is the function of this protein?
Implicated in the export process of the lantibiotic SrtA.
What are the official names of this protein?
Lantibiotic transport ATP-binding protein SrtF.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: Y105_RICCN
Sequence: MLRIVKKLGIILFVSTISINSFAKSMYDDVDSASDYDSTPYYENEGSLVFKMRLGGVVSSAKQKGLPTPTSPQPVSVGEVAKNGYGGDASTTIFFNNYLATELSLGFNVLRTKYTSLAAVAHNYGVDNVKLGKHKPIYMIPATITGQFHIAPYGGIRPYIGIGYHGSYMLTQATGLKIRNGHGAVGQIGVDFYAKDDTLINIDVRQFFLNPKLEYKPNLVGNKTMTSKVKLNPLIVSIGIGFTF
What are the official names of this protein?
Putative outer membrane protein RC0105.
What is the protein family that this protein belongs to?
Belongs to the OmpW/AlkL family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: RTS3_YEAST
Sequence: MIATSRAVNMNKESKHKKAVAKPCRERQTSVTRAMRPAVARDPRRLSTSSSPSSSPMSAQRRLSREEIINEMEKEQDAIVVRLLREIETLKEENSRLKNQLHHPVPARRSSPFFEGESAILDDDDCNYGYTLDTPKLKLTDGASRHTVLPLTPKDSMTHISHSARRSSRNASISNGTSISDTIFPIETKIHSAPTTNRNLPSADLPHHTLLPRSLSGISSSDLTESGALLHDRRRRSSNYSLDGSNSLKADLMAKRFQTGSLK
What is the function of this protein?
May be a component of a protein phosphatase type 2A (PP2A) complex.  Negatively regulates SIT4 phosphatase, a modulators of caffeine sensitivity.
What are the official names of this protein?
Protein phosphatase type 2A regulatory subunit RTS3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AROQ_CELJU
Sequence: MATILVLHGPNLNLLGLREPGIYGATTLADINQTLSEMATKAGHHLQYLQSNAEYELIDRIHDARKEGVDFIIINPAAFTHTSVALRDALLGVDIPFIEVHLSNVHKREAFRHHSFFSDVAQGVICGFGATSYELALQAAFKILGTPV
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: HMG_TETPY
Sequence: GKVKDDKPAPPKRPLSAFFLFKQHNYDQVKKENPNAKITELTSMIAEKWKHVTEKEKKKYEGLQQEAKAKYEKDMQAYEKKYGKPEKVKKIKKSKKGSK
What are the official names of this protein?
High mobility group protein, Non-histone chromosomal protein.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PROA_BURO1
Sequence: MDIDQYMTDLGRRARHASRAMARASTAAKNAALDAVARAIERDAQALKDANARDVARAREKGLDAAFIDRLTLSDKALNTMVEGLRQVASLADPIGEIGNLKFRPSGIQVGQMRVPLGVIGIIYESRPNVTIDAAALCLKSGNATILRGGSEALESNAALAKLIGEGLEAAGLPQDAVQVVATADRAAVGKLITMTEYVDVIVPRGGKSLIERLINEARVPMIKHLDGICHVYVDDRADLAKALTVCDNAKTHRYGTCNTMETLLVASGIAAKLLPPLGKLYRDKQVELRVDAAARAVLADAGVGPLVDVTEEDWHTEYLAPVLAIKVVDGLDAAIEHINHYGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHARGPVGLEGLTSLKYVVLGHGEGRQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
Protein: ATPE_DAUCA
Sequence: MTLNLCVLTPNRTVWNSKVNEIILSTNSGQIGVLPNHASVATAVDIGILKIRLDGQWLTMALMGGFAIIGNNEITVLVNDAEKGSDIDSQEAQQTLEIAEANFRKAEGKRQKIEANLALRRARTRVETINAIS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: QUEF_METFK
Sequence: MSSQPSKALETFDNPTPGRDFHIHMEIPEFTCLCPKTGQPDFAVLYLDYIPDQKCVELKSLKLYIWSFRDEGCFHEAVTNQILDDLVVATDPKFMRLTAKFYVRGGIFTNVVAEHRKPGWQPQPRVELAEFESQSNIRG
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDA_DESRM
Sequence: MSDKKWTAEQLAAITTRDTNLLVAAAAGAGKTAVLVERIIGLITDPHRPVDVDQLLIVTFTNAAAAEMRERIGQALSKALQENPHSKRLARQLTMLNRASITTLHSFCLDLLRRYFYQLDLDPGFRVADEVEAELLRLDVLEELFERRYNQDNVEVFARLVDSYGGQRDDSRLQDLVLELYRFSGSHPLPVQWLTSLAENYVIPEGKTLDDQTWIVQIKKTIFQEVEGVLGLLKQAQWLAKQPGGPEPYSKTLTEDIINIKPLTNNDWDASWEKLYRSITAIKWSKLSPCRGEIDDQLKNKAQNLRNKAKEKFNDIINTYFSAEPTVILEDLRSLQPLIADLAKLTIEFMELYQKKKQAKGLVDFGDLEHYCLTILLDKENDAAEFRPSAVAIELQQQYAEVLVDEYQDINAVQETILRLVSKKNNRFMVGDVKQSIYRFRLAEPKLFLSKSELYANTDNCQGTRIGLSKNFRSRLEVVNAVNFIFRQIMTKKAGEITYDELEELHCGADYPQAEDVKTATGPVEVYLIDRKDAQLEEQNTDSAEEKLTDGEEQEDLDSDQAEARLIGRRIQAMVKGTDKAMGPEFKVWDKEIGKYRPVSYRDIVILLRATTGRANTFLEELRTMGVPTYAEVGTGYFEAVEVETFLSLLKIIDNPRQDVPLAGVLRSPVVGLKASDLAEIRLCSKEGDFYDAVRIAAAADLGDVAVTLTKFLRQLENWRSRARRDTLADLIWLLYRETGYYDYVGGMVGGTQRQANLRVLYHRAKQFEATSFRGLFRFLRFVERLKDSGSDLGAARSLSENEDVVRIMSIHKSKGLEFPVLFVAGLGKRFNMMDLNKDMLMHKELGLGPQIIHLGSRVSYPSLPKLLIKQQIRKESVAEEMRVLYVALTRAREKLILVGAVRDLEKSLEKWCTSTYQAGWTLPDAELMAAKCYLDWLCPAIARHHNGHELRSLAKTEGQPFSEVATDPSAWQLVFQALKDIKNQTQENKEQSQGLLVKIKDMEPFEDAGLIKEVERRLSWQYPRAEVTTRPAKAAVTEVKHKFDELARQEAGVMSYRPKISGRPRFLQQDKGLTPAERGSAIHLVMQHIPLDKLPDEEGVQVLLQNLIQKEILLPQQAAAINPNHITGFFASSIGQRVLQAPKVERELPFSLALPATEVYQELPECGDEMVLVQGVIDCLVDEGDGFLLIDYKSDAVYPGQDSPVDRYRGQINLYARAVQDILGKPVKDRVIYLFNNGQIVHI
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: YBEY_STAA9
Sequence: MFTIDFSDHTGLVKDAWYKQIEDLLEFAKKEEHIEDDAELSVTFVDKQEIQEINRTYRDKDKVTDVISFALEEDEPEIDFSGLDIPRVLGDIIICTDVAQEQANNYGHSFERELGFLALHGFLHLLGYDHMTEADEKEMFGRQDTILNAYGLTRD
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARMH2_ARMME
Sequence: MVTQVPSSTNILVIGGGPAGAYAAGVLVREGFEVTLLEKDFFPRYHIGESMLPSWRQFLRFIDMEEKMKNYGFLPKPGGAIKLNQDKREGYTDFIANNPENSAWNVVRSEFDQLLLNHVAEQGVKVYEGTRVDEIHFSPEEPTRPVSLTWSKDDKTRGDISFNWLVDASGRNGLMSTKYLKNRTFNRSLKNVAVWGYWTGTNRYAPGTNRENAPWFEALTDETGWVWFIPLHDGTTNVGVVLVEEDSKRKKAEYRAKHEGKSLAEVQYDRYMEDIQLAPGLIGLLGDGKFDGKLQAAGDYSYHASGYAGPHFRIAGDAGAFIDPFFSSGIHLAFTGGLSAACTIAASIRGHCTEEEASEFHSSKIKTAFTRFLFVVLGIYKQLRAQQSQILYEADEESLDRAILSLRPVIQGAADADADLTKEELENTLDFCKSVLEDEPQANGNGAAKQDAVPAPIPVALSSGAGPEKDAKRREIEAESLRSLQEMDDCKRNFGTEVINGFFVKMEQGVLGLVRA
What is the function of this protein?
Flavin-dependent halogenase involved in the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols.  The halogenase catalyzes the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product.  The enzyme acts on free substrate and does not depend on carrier-protein-dependent acceptor molecules.
What are the official names of this protein?
Flavin-dependent halogenase armH2.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: RUN3B_DANRE
Sequence: MASLNLGFSGARKKAAARIRAVERRNLITVCRFSVKTLIDRSCFETIDDTSAEFINFVSILEHILSHRLKGQVSWFGYESPRSFWDFIRMACSKVPHSCIHSIENMENVRSSRAKGRAWIRVALMEKRLSEYISAALRDFKTTRRFYEEGALLLGEEAGLLADTLIGLNAIDFSFCLKGEGLDEDCPVVIDYTPYLKFTQTSDSISSDEEEMRTLGSSGSEAGTPESHMAASLMADQSSWFSKSKRLEQKYRVVLEQRGYLEELVRLREAQLSESVSQNKALLQRLTDTEISHKLEKEQLEIIILELQDQLTVLKNHDLRSRQELTSHLTNQWPSPGALDGNAVALDTLLYRKRTGPWEEKSFPSLEQLSADMSLSQTSLDPVQLNTHSLDSKAGLAHWHREGKEDTPSLRGLCGSLTSMASYKSLASLKSSEYLASPTTDMTSPGLTPS
What are the official names of this protein?
RUN domain-containing protein 3B.
What is the protein family that this protein belongs to?
Belongs to the RUNDC3 family.
Protein: SPIR1_HUMAN
Sequence: MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWAVCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQCMETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEGLGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLAMRPLSMSYSFDLSDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSPGPSEYCPSERTISEI
What is the function of this protein?
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703).  Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823).  Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703).  Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703).  Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480).  In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361).  Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361).
What are the official names of this protein?
Protein spire homolog 1, Spir-1.
What is the protein family that this protein belongs to?
Belongs to the spire family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11 (By similarity).
Protein: ENPL_MACFA
Sequence: MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEDEPEEEPEETTEDTTEDTEQDEDEEMDVGTDEEEQETAKESTAEKDEL
What is the function of this protein?
Molecular chaperone that functions in the processing and transport of secreted proteins.  When associated with CNPY3, required for proper folding of Toll-like receptors.  Functions in endoplasmic reticulum associated degradation (ERAD).  Has ATPase activity.  May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity).
What are the official names of this protein?
Endoplasmin, Heat shock protein 90 kDa beta member 1.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen. Melanosome.
Protein: NOTUM_DROME
Sequence: MAVEQIDKMAAKAGEATNKWIKPQQPLLTLLLLLATFSQLPAVCSSSILDAASLQEKDPLRDTSMNMIQRNYMVMHSASGSGDHSRSLKRANLANTSITCNDGSHAGFYLRKHPSSKKWIVLLEGGWHCFDVRSCRSRWMRLRHLMTSSQWPETRDVGGILSPHPEENPYWHNANHVLIPYCSSDSWSGTRTEPDTSDRENSWRFMGALILRQVIAELIPVGLGRVPGGELMLVGSSAGGMGVMLNLDRIRDFLVNEKKLQITVRGVSDSGWFLDREPYTPAAVASNEAVRQGWKLWQGLLPEECTKSYPTEPWRCYYGYRLYPTLKTPLFVFQWLFDEAQMRVDNVGAPVTPQQWNYIHEMGGALRSSLDNVSAVFAPSCIGHGVLFKRDWVNIKIDDISLPSALRCWEHSTRSRRHDKLKRSTEPSTAVSHPEHANNQRHQRHRQRLQRQKHNNVAQSGGQQRKHNHLSKEEREERKRLRQEQRQRRKQRRRQQQQKKANGGQEHRNKKDNSPKSSNGNDQRKQRRRQQLTAEERQEQRKRRRKAQQQQMKMQREQPAAGVFLEASAPQKTRSSNNASAGTKSKKRHRVPRVPEKCGLRLLERCSWPQCNHSCPTLTNPMTGEEMRFLELLTAFGLDIEAVAAALGVDMHTLNNMERTELVNMLTQQAN
What is the function of this protein?
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins.  Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175).  Also acts as a regulator of long-range activity of Hedgehog (hh), possibly by regulating the switch between low and high level hh pathway signaling (PubMed:20412775, PubMed:22872085).
What are the official names of this protein?
Palmitoleoyl-protein carboxylesterase NOTUM, Protein Notum, Protein wingful, dNOTUM.
What is the protein family that this protein belongs to?
Belongs to the pectinacetylesterase family. Notum subfamily.
What are the subcellular locations of this protein?
Secreted. Cell surface. Note=Associates with the cell surface via interaction with sulfated CAG chains on glypicans.
Protein: NDHI_CHAPD
Sequence: MFPMVTEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSILDDYTIRTILNLPERKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: CH101_RHOBA
Sequence: MATAKKINLRPLDDRVVVQPSEAEETTAGGIVLPDSAKEKPQRGTVVAVGPGKLLDSGNRGELSVSVGDVVIYGKYGGSEIEVDGHEMKILRESDILAKIG
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES 1, 10 kDa chaperonin 1, Chaperonin-10 1, Cpn10 1.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRTEB_CORGT
Sequence: MMEKIRLILLSSRPISWVNTAYPFGLAYLLNAGEIDWLFWLGIVFFLIPYNIAMYGINDVFDYESDIRNPRKGGVEGAVLPKSSHSTLLWASAISTIPFLVILFIFGTWMSSLWLTISVLAVIAYSAPKLRFKERPFIDALTSSTHFTSPALIGATITGTSPSAAMWIALGSFFLWGMASQILGAVQDVNADREANLSSIATVIGARGAIRLSVVLYLLAAVLVTTLPNPAWIIGIAILTYVFDAARFWNITDASCEQANRSWKVFLWLNYFVGAVITILLIAIHQI
What is the function of this protein?
Catalyzes the elongation of the C(40) carotenoid all-trans-lycopene to the acyclic C(50) carotenoid flavuxanthin during decaprenoxanthin biosynthesis (PubMed:11432736).  Acts as a bifunctional enzyme that catalyzes the elongation of lycopene by attaching a C(5) isoprene unit at C-2, as well as the hydroxylation of the new isoprene unit (Probable).  The enzyme acts at both ends of the substrate, forming the C(50) carotenoid flavuxanthin via the C(45) intermediate nonaflavuxanthin (PubMed:11432736).
What are the official names of this protein?
Lycopene elongase/hydratase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PQQB_XANOM
Sequence: MRIIVLGSAAGGGHPQWNCHTPASLRAWQQADGAQRRTQASIAVSADGERWVLINASPDFRQQILATPALWPQQGLRHSPIKAVLLTSGEIDHIAGLLSMRESQPFALHASRRVLDLLAQNPIFDAVNPQYVSRQPFTLNAPLTVSGLQLTPFSVPGKVPLFMESRSGGDLAGSQEETLGLTIDDSQHRVHYIPGCAAMTDALRARLHGAELVFFDGTLWRDDEMVQLGISQKTGQRMGHMSIDGPEGTIAAFAPLNVARKIFIHLNTTNPVLNTQSPEFATARASGWEVAHDGLEIAL
What is the function of this protein?
May be involved in the transport of PQQ or its precursor to the periplasm.
What are the official names of this protein?
Coenzyme PQQ synthesis protein B, Pyrroloquinoline quinone biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the PqqB family.