Protein: GCY_TOXGG
Sequence: MKKTRTTAAERSQRARKRPHDEHRGRGREHGGARDPGAGGQAMKGAEKGRNPKHQATQKQMSFLQGKHQQRVGNVVSRLGPAAVGQTTLMDKKRKLYSDTSQQPLWSLRKITINPTDKDDLRRFPSNAIYTHRYSAMTFIFKNLWEQFHRVINWWFLVMAIIQAIPQLHYNPNHAWSTALPFAIVLVFGMLKDAFTDLGRRERDRVLNQRVCCIVDGHTPQLRLLQWQGVRVGNILRLTDGEEVPADIVVLATSNTDGVAYVETSKLDGETNLKFKQGVKETRGESSPLSIAGIRGRVVCEKPCAVMDAFTGSLKLDAHPRATPLDIVNFIQRGSHIRNTEWLYGVVIYTGEDTRIQKNAAPPGFKRPHIEKDINTYLFISFFIVFLTILISVMSKWSVQERDSGDTGVTDAGASSGSGSSSGETSQTYGSSVEFMLGSRDLLQNPWMSILRFLAVYAPVLPLSLPLILDVVYLLQSVLIEGDIHIRGGGRTPATGRGNGSTSSMTVADDGLPDGEAGGLDSAHSSQNASLQQPLSIVSKGFSKTRRFLSEKFSSPSSGQIGGNQDRRETPREDDERETNGENVPSATPLLPGGEAACVATGDEETLRADAEGAQERDREAEGNREQLKSVPTGTHAAWRPGALDSTAEANEDEDPDVLHAEKASGFGARRSDDRDRKSSCSRYPETGGEKTSHAISGRFTGSVMPSTYTKLHGDIANAGFESAWQPYANGHTHTRTLLLATGGGPNSLCATGNFEREDVWAEVHTPALNPNLGQVDFIFTDKTGTITENDMTFSMCSVAGKIYGMASCGGAGYEGAESSEYGSRVWTANETSARSSRDRLVPHLQRGTSAASSRSQSAPASANDEGTPRRIPTLMLRPQTLTNQQTGQQSPVLPASREDEKGKDASPGAADSPASSLSVSRFFGSVSYEGRLEETGSQKEEDSRSDRVSLSPSEGRVSGSRPQLACEGIHGATLRRRTVGIQSQHSSQSLLSSRQQSEDERQYTEGEEGETEDDRSTVSRRGRDRMYSRDYHRESRSSSPRDGELSDRYPLRCIRSIGDGYIIRGGRTGNVVMRHPSGMSFDSRPSSQFTFSSPVVGDDSFDDPRRAMYFGRGSPRSLTPPSERGTASPSVGEEGPPLSPQISPTGSARGRVPRSSSLYMPAVDEGEDRERYFRPRRRMLRPGASLLPPLSPSPSRAGVPFLYDNIDFPTGFRETPMEGQIRRNCDFYDASIFTDLARKDLRSHRINEFIKCMALCNTVVPWVYTATPCSSSCPGLPSTANFSVAAYPTGGGANSLFSCSASAFAGPVTQGFPSVTHPAALASDGAAGADEDEEKNVSQLLLPSGTSASSGAPSGPRGDPQLVSLLGRQGQGHGSLGAPGSGLPTSGCLGGAGGSGARGPMGLHGSRRSLPGSSDCRVPSTARPAPLLGSDAAGRGFGPDYVPSPRPLSPAGPPNASTGSLGEAPKADKPASPEEAASPGKDGEEAPSSTPRCVFAPSTLVPPSVLRSHTGAGGLRPSKSLARGVSFKEKHEEFAFSKDEDTATVDQDDTQSATDEEHDVEGEEEEAGKSAERLTKAKRNRSASASLMSLKSKVTASGRDVADLLFRRGSRGNSGTDPDPASARTVGRSSSVERAQQPPTHGGFSTVTGTGESRSSLVSIIKYQASSPDEECLVSAASHMGYTLVSRTNNYAILNINGQERRWQIIGVNEFTQKRGRMSIVVRPQEWTEGSILYVKGADVAMLDLLSTSFTRGHDFRQSFSCLSRYAESFSGGRGPQVSLSRLQSNSSAKGSGGPPVRRSVSGSDPRLQPSRSVSLPRTVPPGQETPMAGDQLEGPEAAETVNPSGQTYSQGEEEEGLRSRLARADSMLRSLNPALYNYDKQHQRGHGPEGDEGSHELEGHDAHTGDSHGGHHRDQAEPRAGDAVGPESASRLPQKTQNRLPQHLGNAGVCAHGHAWTPSEENYCAAFFDDDEDELIALGDIALVEQHLKRFSLQGLRTMALACRYLTQEETETYKRLYTDACASVYCRAERLEEVAEDMERDLEYLGITGVRDKLQEQVPETLQLMMEAGIRVWMVTGDNVEYALHICHSCRLLTSRTRIFHAALEFSGRKAKREGVMLYELFRKARRLKRSDEHICLVVTGPNLRTFLNHPDLQTYFLNMACCSDVVVAARVTPSQKAEMVRLVKKRLTPQPITMAVGDGGNDVAMLQEAHVGVAIRGKDSAAAVAAAYADYSFTEFRFLQRLLFVHGRLSLMRVSTVILWSFFKSLCIGLPTFLFQPQAFWSAVEVYDPLLLMIVDFFWTTLPGIIHGYSDQDLPTHLLPSVPVLYTPGRRRLYFNGFRFILWTVEGIIYSFLIFYLLQATWMDGNTFHDGQVLGFHSYGILLLFGSLLQSNVRIILETSLWTPTFLFTTIVLCTIMFFPTVLLYSVTGWPRRYMELAGRVVFAWPMLYFLIPLWVSIGILVQLLLQVFTSSLFPNISGSVKQYLAQKQADVNYRRKASKHPFSQPRPRLLPGGHDEYGLFCGMGSCWSLFKRSLWFMGGCCLMDTPNVADDFTASPALCAELRERFNPLRRKSVADRLPPPRRFRINENFLSYTGASEEKGADGVQRDLGGKGSACGPGAAGLAAGTGAPGAGRSKSVFGGGGGVMPMADMAADLETENSLSSNGSEQEKAGDNVTKLVKVSHLINRFTLRFKDMQLEADYQIHNKKSFLKRLVPWYRVIFMLIALYQLLSFLTEYFIDIHWNPGETEMEPWMCVPTLVVEIGFAAVVVCTFYDFIFLDHFSLILNSIVFLMVSSSIVFYTASHVDGTLTSVLFPVFTFVILRISFLQAVVWNILFLIVTVARFMLDKKYLPPLNFVHYIPLFIGIDVFVAFVGYRLEYNQRKSFLLDYSVDASRRKQREILNTMLPSFVVDQMINSELNEEGIPTSLKAEDRGTVSVIFCDVYEFQHVVASIEPTRLVEVLDSLFLCFDRSAEQFGCTKIETVFETYLAAAGLQPGREASPASYQQDACDALDMALAMLEVAAQIRYEVKSNQGVLSGSAVGSSSAVGPAVSASNLEASGNHMEPRLSLHGHNSGVAMGSRMNSSRFHRQKTGSVVRTVLQSRPQRIRVKIGIHSGRVISGVVGAKKPQYALFGDTVNTASRMKTTGQPGYIHISEDSYELVKGDDTLEYESRHTEVKGKGLMNTYLLVRVKGSPYPHFDDQEADEGDVISETGGQNGESRRSTASLPRQLETAGASSGVHTGEAMGCFASVGSRGESQTAADAAAAEAIEEDIQVEIDEEGVVEDTVEKAVEDVRRLRNEGSHAVASDDFPVSQAGAAQPRRCSRFLFQNAEEHGAAEPQRGEGARLILSPGQTEGTRQSEKEGSALGSNIAASARADRRPAGRREDSRGDSRFDYESMTTQQLLRIYRRQQKVAKVLQWIDEELRGQRDTAHRHARTADIVAKLLASSGDEQAAGESSEADHDEVPLDEIKEELRRQAREANEQESAKRSGGDAPPHTPTRKALLKAFRSEIVHGCAAPTEEEKTAKEGRESEVALASPETESRDANGQRVSERDASDAREGSASPQPDHAAPPSGLPQGLKGQETEKQQGWKLFRSASLVRAAGQSFASLFRRRKPAAPSEAASPSSADTPMDSRVSPTSVDDEDLEQNRVTRIGVSSEWLLLKFKDKNLEARYRTHFYNNKSNINTIEQALIIFLVTFCVQTLTRLALPRFYVVCSHHTINLHVCTGLYWAVRATYTLAAFVLWMLFHYRNRKEVATCLELRWMVFLLNLLFISASCVFALSNSWGVCGQQQEDHGASETAVENTLVALSHLAKDGSFPADDAEVNSVAGSPLAQAMHSPFTTAGVSRASRMLRSGGVSVSGGTDCTGVGTSGEEGSDLVTANGRAYTYWLLSDTIELFFYIVILHHNTGLLFQNCILVDVLLMTMSLTFIITTARETASTVSTIATFPCYVFFNLVSAYCKEYIDRLTFYVNEHAKTTESRATQLLNDMLPKQVLEEFQQDKLKLAYLHENVTFLFADICGFTSWAKGVDACEVVTMLQKLFAKFDKDSTKFGLYKLCTIGDAYVAVSEPVTAENAQDTDPREGMWLVYEMAKAMIGNITEVRERLCIPNLNMRIGLHYGSCVGGVIGSGRLRYDLWGMDVLTGNMMESNGVPGKINVSEILKNEMEKGFPGEFVFKFNKTVAVLQSTVDSYLIRPAKDFDEDEELAAAAATMAVAGPSASLQQGGGAIPQVQAVASGLRRDATSIRGNYRRRFTILGSAPRVLGRRQSLRGHQFSALALASHGDSGPSDEPRHLGDEGQAAGSVTSHDGPLREEVEDDEIDGLKQLRKEIERAGGLGLDASPSDIGSTPGSALGS
What is the function of this protein?
Catalyzes the synthesis of the second messenger cGMP from GTP (PubMed:30992368, PubMed:31235476, PubMed:30742070).  During the tachyzoite lytic growth cycle in host cells, detects and transduces environmental changes in potassium, phosphatidic acid and pH levels (PubMed:31235476, PubMed:30992368).  By producing cGMP in response to these environmental changes, activates PKG and thereby regulates PKG-dependent microneme secretion which is essential for tachyzoite motility, host cell attachment invasion of and egress from host cells (PubMed:30449726, PubMed:30992368, PubMed:31235476, PubMed:30742070).  May play a role in the fission of connected tachyzoites at their basal pole during egress (PubMed:30742070).  Does not display flippase activity towards phosphatidylserine, phosphatidic acid or phosphatidylcholine (PubMed:30742070).
What are the official names of this protein?
Guanylate cyclase, TgGC, Guanylyl cyclase, TgATPaseP-GC.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical cap in extracellular tachyzoites (PubMed:30449726, PubMed:30992368). During tachyzoite intracellular replication in the host cell, localizes to the apical cap, to the cytoplasm in disperse foci and to the residual body (PubMed:30992368, PubMed:31235476, PubMed:30742070).