PharMolix/UniProtQA huggingface dataset:
Protein: CCDB_ECOLI
Sequence: MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEVADLSHRENDIKNAINLMFWGI
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system, functioning in plasmid maintainence.  Responsible for the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system.  Half-life of over 2 hours.  Cell killing by CcdB is accompanied by filamentation, defects in chromosome and plasmid segregation, defects in cell division, formation of anucleate cells, decreased DNA synthesis and plasmid loss.  Interferes with the activity of DNA gyrase, inducing it to form a covalent GyrA-DNA complex that cannot be resolved, thus promoting breakage of plasmid and chromosomal DNA.  DNA breakage requires hydrolyzable ATP.  Toxicity is inhibited by labile antitoxin CcdA, which blocks the activity of CcdB; CcdA also removes bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation.  Also acts to inhibit partitioning of the chromosomal DNA.  Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdA.
What are the official names of this protein?
Toxin CcdB, Cytotoxic protein CcdB, LynB, Protein G, Protein LetD.
What is the protein family that this protein belongs to?
Belongs to the CcdB toxin family.
Protein: NU6C_GOSBA
Sequence: MDLPGPIHDFLLVFLGSGLILGGLGVVLRINPIYSAFSLGLVLVCISLFYILTNYHFVATAKLLIYVGAINVLILFVVMFMNSSEYYKDFNPWTIGNGLTSLVCTSILVSLISTILDTSWYGIIWTTRSNQIIEQDLIGNSQQIGIHLATDFFLPFEFISIILLVALIGAIDVTLQ
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: UNG_CHLTA
Sequence: MHEAFTIEQLPPSWQEQLKDEWSQPYWSQLLAFLKSEYAQATIYPKKENVFAALQSTPFDQVRVVILGQDPYHGEGQAHGLSFSVPRGQALPPSLRNIFQELHTDLGIRNESGCLQAWADQGVLLLNTVLTVRAGEAFSHAGRGWERFTDAIVTKLIQNRTHVIFVLWGNAARQKCNLLFQTKHQHAVLACPHPSPLAAHRGFFGCCHFSKINYLLKKQGKTMINWKIE
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_FRAT1
Sequence: MNRLKKGDDVIVIAGKDKGRRGVVKSFAKGGSLVLVEGINIVKKHIKPNPNRGIEDGVVEKELPVDASNVAIFNPATEKADRVGYKFVDEKKVRYFKSNGELVDL
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: SNX1_ARATH
Sequence: MESTEQPRNISGSMQSPRSPSSHPYLSVSVTDPVKLGNGVQAYISYRVITKTNLPEYQGPEKIVIRRYSDFVWLRDRLFEKYKGIFIPPLPEKSAVEKFRFSAEFIEMRRAALDIFVNRIALHPELQQSEDLRTFLQADEETMDRFRFQETSIFKKPADLMQMFRDVQSKVSDAVLGKEKPVEETTADYEKLKHYIFELENHLTEAQKHAYRLVKRHRELGQSLLDFGKAVKLLGACEGEPTGKAFSDLGTKSELLSIKLQKEAQQVLMNFEEPLKDYVRYVQSIKATIAERGTAFKQHCELSETTKLKEINLDKLMLTRSDKVGEAEIEYREIKAESEEATRRFERIVKRMEDEIVRFQEQKTEEMGVAFHQFAKGQARLANSVADAWRSLLPKLEASYSV
What is the function of this protein?
Plays a role in vesicular protein sorting.  Acts at the crossroads between the secretory and endocytic pathways.  Is involved in the endosome to vacuole protein transport via its interaction with the BLOS1/2 proteins and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport.  Required for the auxin-carrier protein PIN2 sorting to the lytic vacuolar pathway and the trafficking of several plasma membrane proteins.  Also involved in the efficient sorting of seed storage protein globulin 12S.
What are the official names of this protein?
Sorting nexin 1, AtSNX1, Vacuolar protein sorting-associated protein 5 homolog.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PSB1_SULIY
Sequence: MVIMGNELQLENKILKGTTTVGIKVNDGVVLAADRRASAGFFVANKMVRKVLYITDKIGITTAGSVADLQFIYDVLKNIYHYNSITKYGPISIKGIATRLANVLSATKYFPYIVQILIGGYDDQPRLFNLDYLGDITEENYVATGSGSPVAMGVLEDEYNPKMTLDEAADLAKRAVFSAIKRDSFTGTGVIVAKIHSKGHEELEFYLNKKV
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta 1, 20S proteasome beta subunit 1, Proteasome core protein PsmB 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGC_CHESB
Sequence: MTAKIFIDGEHGTTGLQIRARLGERRDIELLSIPVERRKDPAARAEFLNAADIAILCLPDDAARESVSLIANDTTRVIDASTAYRVSEGWAYGFPEMDKSQSKAIAQAKRVANPGCWPQGPIALLRPLVSAGLLPADFPVTINGITGYSGGGRSMIEDYEGKGEDAPEFFPYGLTLSHKHLPELRTYAKLARDPLMQPVVGNFAQGMITMVPLQLGHLPRVPKGEELHAAIADHYAGIEGSAVEVAPFQAIERSPEIEPERYNDTNTMRLYVFANDARAQALLLAVYDNLGKGASGAAVQNLDLMLSGLR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 5DNU_ECO81
Sequence: MKQSHFFAHLSRLKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGNVNAERIALLAMYHDASEVLTGDLPTPVKYFNSQIAQEYKAIEKIAQQKLVDMVPEELQDIFAPLIDEHAYSDEEKSLVKQADALCAYLKCLEELAAGNNEFLLAKTRLEATLEARRSQEMDYFMEVFVPSFHLSLDEISQDSPL
What is the function of this protein?
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
What are the official names of this protein?
5'-deoxynucleotidase YfbR, 5'-deoxyribonucleotidase, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the 5DNU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM265_HUMAN
Sequence: MEDEEKAVEILGNTEAAHPPSPIRCCWLRLRCLAATSIICGCSCLGVMALVFAIKAEERHKAGRSEEAVRWGARARKLILASFAVWLAVLILGPLLLWLLSYAIAQAE
What are the official names of this protein?
Transmembrane protein 265.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: URE3_ENT38
Sequence: MELTPREKDKLLLFTAALVAERRLARGVTLNYPESVALISAFIMEGARDGQTVAELMEAGRHVLTRAQVMEGVPEMIPDIQVEATFPDGSKLVTVHNPIV
What are the official names of this protein?
Urease subunit gamma, Urea amidohydrolase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the urease gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF_ALTMD
Sequence: MAILDVLSFPDERLRTVAKPVEEVNDEIKQLVSDMFETMKDENGIGLAATQVNRHVQVVVMDVSEDQNEPRVFINPEITRKDGSTISEEGCLSVPGNYAKVERAEAITVKALDQNGEAFELDAEGLLAICIQHELDHLKGKLFIDYLSPLKRQRIRKKLEKEARLAAKA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: SYH_BURP1
Sequence: MTEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTPIVEHTQLFTRGIGEVTDIVEKEMYSFVDALNGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYLGPMFRHERPQRGRYRQFHQVGVEALGFAGPDADAEIIMMCQRLWDDLGLTGIKLEINSLGLAEERAAHRVELIKYLEQHVDKLDDDAQRRLYTNPLRVLDTKNPALQEIVRNAPQLIDFLGDVSRAHFDGLQQLLKANNLPFTINPRLVRGLDYYNLTVFEWVTDKLGAQGTVAAGGRYDPLIEQLGGKPTAACGWAMGVERILELLKEEHLVPEQEGVDVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVANGTVSVKPLRGTGAEGEKNVQQSVPVESLTEFLINAMVATAEDGDD
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1571_METTP
Sequence: MDDELADLRRKKLEELQRRQLESQLYAAQQEQMQQELEAKKQAILRAILTPEARERLSSIRMTRPEFVAQIEAQLIMLAQSGRIRSAITDEQLKAILKQAQPKKRDIKIRRI
What are the official names of this protein?
DNA-binding protein Mthe_1571.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: COBQ_LIMRD
Sequence: MTVQSIMFQGTASDAGKSWLAAAVCRILANRGQKVAPFKSQNMALNSFITEKGDEMGRAQVFQAEAAKVKPDVRMNPILLKPSTDKDSQVIVMGKVLKNMDAVSYYQFKRELIPQIMMAYNTLADENDVIVLEGAGSPAEINLNENDIVNMGMARMADAPVILVADIDKGGVFASIYGTIKLMPREDQQRIKGIIINKFRGDKSLLESGNKMIEKLTGIPVIGVLPMSSIDIDEEDSVSLIRKPRQKDTQKDLDVAVIDLDKISNFTDIHSLEIQPDVSVRYVLTAEELGTPDLLIIPGSKNTNADLVALRKNGIAEGILRAHKDGSMIVGICGGYQILGQMLYDPTGIESPIKEQKGLGLLDTETTFNEKKTTTQAVAKRNNYILKGYEIHMGTTKRGLNSTPFSTIQETNGQPENREDGAVSTDGTVIGTYLHGIFDNPYWTRHLLNQLRVAKGMAPLVDTTVSISGYKDQQYEKLAQLFAQNVDMDKFNQILQDSTKE
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: YQJF_ECOLI
Sequence: MKKLEDVGVLVARILMPILFITAGWGKITGYAGTQQYMEAMGVPGFMLPLVILLEFGGGLAILFGFLTRTTALFTAGFTLLTAFLFHSNFAEGVNSLMFMKNLTISGGFLLLAITGPGAYSIDRLLNKKW
What are the official names of this protein?
Inner membrane protein YqjF.
What is the protein family that this protein belongs to?
Belongs to the DoxX family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TTUA_THEMA
Sequence: MKCTKCGKPASVKLRHYNIKLCKEHFNEFIEQRVEKAIKKFKMFGRNSKILIAVSGGKDSVSLWHMLKKLGYEVDALFIRAGKSGMVQKAQEIVEKNAELLNTKLHIVDATEYFGGLSTQEISIMLRRPVCSICGVVRRYLMNKFAYENGYDVVVTGHNLNDEASVLLGNILHWQEGYLERQWPLLPKTHEKLVPKAKPLVLNYEEDIKLYATLNEIPHLEMACPFSVGATSLVYKKILRELEEEQPGITLNFYLGFLKRKKEPKFEVEGLRECKECGYPTTAEVCSFCRLRKQVEKRKNKTPA
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2-thiouridine (m(5)s(2)U or s(2)T) (PubMed:28655838).  This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity).  Can use free sulfide as sulfur source in vitro (PubMed:28655838).
What are the official names of this protein?
tRNA-5-methyluridine(54) 2-sulfurtransferase, tRNA thiouridine synthetase TtuA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family. TtuA subfamily.
Protein: PHD_MYCS2
Sequence: MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Neutralizes the bacteriostatic effect of cognate toxin Doc.  In M. smegmatis 3 TA systems (VapB-VapC, MazE-MazF and Phd-Doc) may be involved in monitoring the nutritional supply and physiological state of the cell, linking catabolic with anabolic reactions.
What are the official names of this protein?
Antitoxin Phd.
Protein: PYRDB_ARCFU
Sequence: MNPLETEIGGLRMKNPLMLASGIMGSKVHSLNLIARDAGAVVTKSVGVEEREGYRNPTVVNWKCGLINAVGLASPAAKDFAEELKDYTNEAPLLISLYGHSVEEFSDLVDTFDSALPYLHGYELNLSCPHVKGAGLDIGMDLELSAAIVEELKGKTKNPVFAKLSAMHDYLKLAKVLEDAGVDGITISNTLRGMKIDIMSGKPVLSNLSGGVSGPAIKPIALKCVYDLYKEIEVPIVGCGGITSFEDVLEFIMAGARAVQIGSAVYYSRRIFYSLKESLIAFTRARDCTISDLIGIAHS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC70A_DANRE
Sequence: MAASGGQKSEKLDEAQALARSCAGRPDFLPCDGLSICATHSHGKCFKLHWCCHLGWCHCKYVYQPMTSVCQLPSTAVPVAPSGHTHTMNLSISLAERFLRTAPKFQAPPCPESPKFCVISDLFVDDYMVKRINGKMCYVQRPPPPTPNPTHQPQTAAPQPVPQRSKNSHQVGPTVKQGQAKEKISAPKMDHCSSPSSSEDSGINALGLHYMESCDEDSCVDDDDEEEEDDELSTDGNSSPGSFWDQDECTLLSPSKSIVEIIEKIETTV
What is the function of this protein?
Plays a role in neuronal and neurobehavioral development (PubMed:31623237).  Required for normal expression of neuronal markers elavl3 and eno2 and neurobehaviors related to circadian rhythm and changes in light-dark conditions (PubMed:31623237).
What are the official names of this protein?
UPF0524 protein C3orf70 homolog A.
What is the protein family that this protein belongs to?
Belongs to the UPF0524 family.
Protein: CFA95_MOUSE
Sequence: MGTFDSQCHECFESKERWYEIGPTDLLERKGSLTLRSHHKKYSEPVLVYSWHRNREAFPKDYDIESLETVKNLCMSTYKRFGSDSPRWMSEAREQMAQVLVNKDLVEKKKTGLLDEETLCPGILERDPELPPTGFRDVPMESPPDPRKPCFSTTYSEDFTPQYEYPPPACPRREEYSIVHRKCRSQFTDLNGSKRLGINTWHDESGIYANSEAKQKLYALARNPIVPF
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
What are the official names of this protein?
Cilia- and flagella-associated protein 95.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme. Cell membrane; Single-pass membrane protein. Cytoplasm.
Protein: DAPA_GEOUR
Sequence: MFKGSIVAIVTPFKNGAVDEEKLRELVEFQIENGTDAIVPCGTTGESSTLDYEEHDRVIEIVVEQVKKRVPVIAGTGSNSTKEAIEMTSHAKTLGADGALLVTPYYNKPTQEGLFLHYKAVADAVALPQILYNVPGRTGVNLLPETVARLAEHKNIVAIKEATGSLQQASEIIDLCGDKIDVFSGDDFITFPMMACGAKGVISVTANIMPKEVAALVDAFFAGKMEEARQWHLKLLKISNAMFIESNPVPVKTAVALMGKCSAEVRLPLAPLAEANKVKLVAIMKEYGLI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEPA_HAEI8
Sequence: MKNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMDLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVAKIPAPEGDPNAPLQALIIDSWFDNYLGVVSLVRIKNGVLRKGDKIKVMSTGQTYNVDRLGIFTPKQEDTTVLECGEVGWVVCAIKDILGAPVGDTLTHQHNSATEVLPGFKKVKPQVYAGLFPVSSDDYEAFRDALGKLSLNDASLFYEPETSTALGFGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVIYEVQLTNGEVVYVDSPAKLPPLNNIAEIREPIAECNMLVPQEYLGNVITLCVEKRGVQTNMVYHGNQIALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQAADMVRVDIMINSERVDALALIVHKDNSQYRGRELVEKMRELIPRQQFDIAIQAAIGNHIIARSTVKQLRKNVLAKCYGGDVSRKKKLLQKQKEGKKRMKSLGNVEVPQEAFLAILHVGKDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YJQC_BACSU
Sequence: MFYHIKELQYQAKPAHPDPVYAKKLQEVLGGQFGEISVMMQYLFQGFNCRADAKYKDLLYDVGTEEIGHVEMLATMISRLLDNAPADVQEDAYKSNPAIAAVMSGMNPQHAIVSGLGAMASDSEGYPWNAKYIISSGNLLADFRANLNAEAQGRLQVTRLYAMTDDPGVRDMLSFLIARDTYHQNMWYAAIKELEERERDIVVPTTFPRELEKQEVSYDLFNFSRGDESSQGRWAHGEAFDGRGEFRYIPAPIAFASAPHLKPAPMWLHNTVPPMSKC
What are the official names of this protein?
Uncharacterized protein YjqC.
What is the protein family that this protein belongs to?
Belongs to the manganese catalase family.
Protein: THID_STAAN
Sequence: MIKPKIALTIAGTDPTGGAGVMADLKSFHSCGVYGMGVVTSIVAQNTLGVQHIHNLNHQWVDEQLDSVFNDTLPHAIKTGMIATADTMETIRHYLMQHESIPYVIDPVMLAKSGDSLMDNDTKQNLQHTLLPLADVVTPNLPEAEEITGLTIDSEEKIMQAGRIFINEIGSKGIIIKGGHSNDTDIAKDYLFTNEGVQTFENERFKTKHTHGTGCTFSAVITAELAKGRPLFEAVHKAKKFISMSIQYTPEIGRGRGPVNHFAYLKKEGLDDELSK
What is the function of this protein?
Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
What are the official names of this protein?
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase, Hydroxymethylpyrimidine kinase, HMP kinase, Hydroxymethylpyrimidine phosphate kinase, HMP-P kinase, HMP-phosphate kinase, HMPP kinase.
What is the protein family that this protein belongs to?
Belongs to the ThiD family.
Protein: PTH_MYCUA
Sequence: MAEPLLVVGLGNPGENYARTRHNLGFMVADLLAARLGAKFKVHKRSGAEVVTGRLAQRSVVLAKPRCYMNESGRQVAPLAKFYSVPPADLIVIHDELDLDFGRIRLKFGGGEGGHNGLRSVAAALGTKNFQRVRIGIGRPPGRKDPATFVLENFSSPERPEVPTICEQAADATELLVEVGLEPAQNRVHAW
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_SYNFM
Sequence: MDKLVIEGGVPLRGEVSISGAKNAALPLMAASLLACGKHSFTNVPRLRDIHTMCNLLGHMGASSEHGATLNIDSGNIRALEAPYRLVKTMRASVLVLGPMLARHGFARVSLPGGCAIGARPINLHLSGLQEMGADIELEHGYVVARADRLRGATIIFDLVTVTGTENLMMAATLARGRTILKNTAREPEVVALADYLRKMGARIEGDGSSEIVVDGVEELTPSTFRVIPDRIEAGTYIAAAGITGGCLRLTNCEPAHLEAVIQKLRAAGLTIETGEGIVDVQSNGPIRSVDIKTWPYPAFPTDMQAQFMSLMTLGNGVSLITEQIFENRFMHVLELKRLGADIELDGRNARVCGVSHLSGAPVMATDLRASASLVLAALAATGVTEITRIYHLERGYEDMDGKLSAVGARIRRQVNGS
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_SULNB
Sequence: MQPYLLLAVGTGGFVGAILRFLISGWVQRLSPTLFPVGTLSVNVLGSFIIGFLALYFESVVAPHQKALVITGMLGALTTFSTFSLETVTMLQGGLWGRVVTNITLNVFLCVVATMLGMMLFKRLYG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CALU_BOVIN
Sequence: MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGMIVDKIDADKDGFVTEGELKSWIKHAQKKYIYDNVENQWQEFDLNQDGLISWDEYRNVTYGTYLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQEPMEDIDKNADGFIDLEEYIGDMYSHDGNADEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF
What is the function of this protein?
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues.  Seems to inhibit gamma-carboxylase GGCX.  Binds 7 calcium ions with a low affinity (By similarity).
What are the official names of this protein?
Calumenin.
What is the protein family that this protein belongs to?
Belongs to the CREC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Golgi apparatus. Secreted. Melanosome. Sarcoplasmic reticulum lumen.
Protein: TET5C_RAT
Sequence: MADEGSSTKDSESFSVLNWDQVSRLHEVLTEVVPIHGRGNFPTLEITLKDIVQTVRSRLEEAGIKVQDVRLNGSAAGHVLVKDNGLGCKDLDLIFHVALPTEAEFQLVRDVVLCSLLNFLPEGVNKLKISPVTLKEAYVQKLVKVCTDTDRWSLISLSNKNGRNVELKFVDSIRRQFEFSVDSFQIILDSLLFFYDCSSNPVSEHFHPTVVGESMYGDFEEAFDHLQNRLIATKNPEEIRGGGLLKYSNLLVRDFRPADQEEIKTLERYMCSRFFIDFPDILEQQRKLETYLQNHFADEERSKYDYLMILRRVVNESTVCLMGHERRQTLNLISLLALRVLAEQNIIPSATNVTCYYQPAPYVSDGNFNNYYIAHPPVTYSQPYPTWLPCN
What is the function of this protein?
Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and enhances mRNA stability and gene expression.  Can also elongate RNA oligos ending with uridine molecule, provided that the sequence is adenosine-rich.  Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein.
What are the official names of this protein?
Terminal nucleotidyltransferase 5C.
What is the protein family that this protein belongs to?
Belongs to the TENT family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Recruited into the centrosome through its interaction with PLK4.
Protein: SBCD_STAAM
Sequence: MKIIHTADWHLGKILNGKQLLEDQAYILDMFVEKMKEEEPDIIVIAGDLYDTTYPSKDAIMLLEQAIGKLNLELRIPIIMISGNHDGKERLNYGASWFEHNQLFIRTDFTSINSPIEINGVNFYTLPYATVSEMKHYFEDDTIETHQQGITRCIETIAPEIDEDAVNILISHLTVQGGKTSDSERPLTIGTVESVQKGVFDIFDYVMLGHLHHPFSIEDDKIKYSGSLLQYSFSEAGQAKGYRRLTINDGIINDVFIPLKPLRQLEIISGEYNDVINEKVHVKNKDNYLHFKLKNMSHITDPMMSLKQIYPNTLALTNETFNYNEENNAIEISEKDDMSIIEMFYKHITDKELSDIQSKKIKNILENELRKED
What is the function of this protein?
SbcCD cleaves DNA hairpin structures.  These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions.  The complex acts as a 3'->5' double strand exonuclease that can open hairpins.  It also has a 5' single-strand endonuclease activity (By similarity).
What are the official names of this protein?
Nuclease SbcCD subunit D.
What is the protein family that this protein belongs to?
Belongs to the SbcD family.
Protein: GDU6_ARATH
Sequence: MRPTPKVEIWKSPVPYLFGGLFLLVLLIALALLSLVCTHQKPSSSSNNNHMDEEDDVGDKDAKPITREYLPKIVVILAGDNKPTCLAVPVVVPPPTSIFRCNCDNVTVIST
What is the function of this protein?
Probable subunit of an amino acid transporter involved in the regulation of the amino acid metabolism.  Stimulates amino acid export by activating nonselective amino acid facilitators.
What are the official names of this protein?
Protein GLUTAMINE DUMPER 6.
What is the protein family that this protein belongs to?
Belongs to the GLUTAMINE DUMPER 1 (TC 9.B.60) family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.