PharMolix/UniProtQA huggingface dataset:
Protein: 25DK1_PSEPU
Sequence: MKCGFFHTPYNLPTRTARQMFDWSLKLAQVCDEAGFADFMIGEHSTLAWENIPCPEIIIGAAAPLTKNIRFAPMAHLLPYHNPATLAIQIGWLSQILEGRYFLGVAPGGHHTDAILHGFEGIGPLQEQMFESLELMEKIWAREPFMEKGKFFQAGFPGPDTMPEYDVEIADNSPWGGRESMEVAVTGLTKNSSSLKWAGERNYSPISFFGGHEVMRSHYDTWAAAMQSKGFTPERSRFRVTRDIFIADTDAEAKKRAKASGLGKSWEHYLFPIYKKFNLFPGIIADAGLDIDPSQVDMDFLAEHVWLCGSPETVKGKIERMMERSGGCGQIVVCSHDNIDNPEPYFESLQRLASEVLPKVRMG
What is the function of this protein?
Involved in the degradation and assimilation of (+)-camphor, which allows P. putida strain NCIMB 10007 to grow on this enantiomer of camphor as the sole carbon source (PubMed:3944058, PubMed:8515237).  Catalyzes the FMNH(2)-dependent lactonization of 2,5-diketocamphane via a Baeyer-Villiger oxidation to produce the unstable lactone 5-oxo-1,2-campholide with (R,R) configuration, that presumably undergoes spontaneous hydrolysis to form 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetate (PubMed:3944058).  Is also able to convert (+)-camphor and norcamphor to the corresponding lactone in vitro (PubMed:8515237, PubMed:21906366, PubMed:23524667).  Shows no conversion of (-)-camphor, (+)-fenchone, (-)-fenchone, and (+)-nopinone (PubMed:23524667).  Acts only on bicyclic ketones; is not active towards monocyclic ketones, aromatic ketones, the aliphatic 2-decanone, 1-indanone and progesterone (PubMed:21906366).
What are the official names of this protein?
2,5-diketocamphane 1,2-monooxygenase 1, 2,5-DKCMO 1, 2,5-diketocamphane monooxygenase 1, 2,5-diketocamphane 1,2-monooxygenase oxygenating component, 2,5-diketocamphane 1,2-monooxygenase oxygenating subunit, Camphor 1,2-monooxygenase, Type II Baeyer-Villiger monooxygenase, Type II BVMO.
What is the protein family that this protein belongs to?
Belongs to the bacterial luciferase oxidoreductase family.
Protein: ACCA_PSESM
Sequence: MNPNFLDFEQPIADLQAKIEELRLVGNDNSLNIGDEISRLQDKSKTLTESIFGNLTSWQIARMARHPRRPYTLDYIENIFTEFDELHGDRHFSDDAAIVGGIARLDNQPVMIIGHQKGREVREKVRRNFGMPRPEGYRKACRLMEMAERFKMPILTFIDTPGAYPGIDAEERNQSEAIAWNLRVMARLKTPIIATVIGEGGSGGALAIGVCDQLNMLQYSTYAVISPEGCASILWKTAEKAPDAAEAMGITADRLKGLGIVDKVIAEPLGGAHRDPVAAAALIREELSSQLAMLKAFDNDALLARRYDRLMSYGL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IXTPA_SYNS3
Sequence: MTNRVLVIASGNAGKIREFSNLLQELPLQVNPQPDGIQVEETGITFRDNALLKARAVAEATGHWALADDSGLSVDALGGAPGVYSARYANSDPERIERLLKELGDRTDRQARFSAALCIAAPDGSVLAAVEGYCEGSITFSARGTQGFGYDPVFEVKNSGLTFAEMTQDHKKQHGHRGRAFALLKPELEKLLENDPGQDAGATPIP
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: THIM_METBF
Sequence: MNDPLKTIRETKPLIHHITNWVTIYDCANMTRAFGALPVMAHASEECAEMTGISSALVLNIGTPTSEIIDSMLLSAAAANEKKIPVVLDAVGVGATKFRDEMAAKILGSVRVDIIKGNYSEIAKLAGESAETKGVEATSINADPVKIAKQFAKLSSSVIVMTGKEDIISDGERVFIVKNGHELMGSIVGTGCMAASVIGLFAAVNPDYFEASREALCYFGVAGELAARESNGPGSFKVNLYDEVFNLSDEKVRSMMNFEEQ
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: HV145_HUMAN
Sequence: MDWTWRILFLVAAVTDAYSQMQLVQSGAEVKKTGSSVKVSCKASGYTFTYRYLHWVRQAPGQALEWMGWITPFNGNTNYAQKFQDRVTITRDRSMSTAYMELSSLRSEDTAMYYCAR
What is the function of this protein?
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin heavy variable 1-45.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: PG145_VACCW
Sequence: MSLLKMEYNLYAELKKMTCGQPLSLFNEDGDFVEVEPGSSFKFLIPKGFYASPSVKTSLVFETLTTTDNKITSINPTNAPKLYPLQRKVVSEVVSNMRKMIESKRPLYITLHLACGFGKTITTCYLMATHGRKTVICVPNKMLIHQWKTQVEAVGLEHKISIDGVSSLLKELKTQSPDVLIVVSRHLTNDAFCKYINKHYDLFILDESHTYNLMNNTAVTRFLAYYPPMMCYFLTATPRPANRIYCNSIINIAKLSDLKKTIYAVDSFFEPYSTDNIRHMVKRLDGPSNKYHIYTEKLLSVDEPRNQLILNTLVEEFKSGTINRILVITKLREHMVLFYKRLLDLFGPEVVFIGDAQNRRTPDMVKSIKELNRFIFVSTLFYSGTGLDIPSLDSLFICSAVINNMQIEQLLGRVCRETELLDRTVYVFPNTSIKEIKYMIGNFMQRIISLSVDKLGFKQESYRKHQESDPTSVCTTSSREERVLNRIFNSQNR
What is the function of this protein?
DNA helicase which seems to act as a postreplicative transcription termination factor.  Involved in ATP-dependent release of nascent RNA.  Forms a stable complex with single-stranded DNA, and to a lesser extent RNA.
What are the official names of this protein?
Transcript termination protein OPG145, 56 kDa abortive late protein.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Poxviruses subfamily.
Protein: RSMAF_MYCTU
Sequence: MSAADKDPDKHSADADPPLTVELLADLQAGLLDDATAARIRSRVRSDPQAQQILRALNRVRRDVAAMGADPAWGPAARPAVVDSISAALRSARPNSSPGAAHAARPHVHPVRMIAGAAGLCAVATAIGVGAVVDAPPPAPSAPTTAQHITVSKPAPVIPLSRPQVLDLLHHTPDYGPPGGPLGDPSRRTSCLSGLGYPASTPVLGAQPIDIDARPAVLLVIPADTPDKLAVFAVAPHCSAADTGLLASTVVPRA
What is the function of this protein?
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigM.  ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP).  RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regulatory protein, liberating the sigma factor (By similarity).
What are the official names of this protein?
Anti-sigma-M factor RsmA, Regulator of SigM, Sigma-M anti-sigma factor RsmA.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: FICD_CRIGR
Sequence: MPMASVIAVAEPKWISVWGRFLWLTLLSMALGSLLALLLPLGAVEEQCLAVLRSFHLLRSKLDRTQHVVTKCTSPSTELSVTSGDVGLLTVKTKTSPAGKLEAKAALNQALEMKRQGKREKAHKLFLHALKMDPGFVDALNEFGIFSEEEKDIIQADYLYTRALTISPFHEKALVNRDRTLPLVEEIDQRYFSIIDSKVKKVMSIPKGSSALRRVMEETYYHHIYHTVAIEGNTLTLSEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINTTLVSRIGSVTIDDMLEIHRRVLGYVDPVEAGRFRRTQVLVGHHIPPHPRDVEKQMQEFTQWLNSEDAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITILKEQRSEYYHVLEVANEGDVRPFIRFIAKCTEVTLDTLLLATTEYSVALPEAQPNHSGLKETLPVRP
What is the function of this protein?
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (PubMed:27918543).  The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (PubMed:27918543).  Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:27918543).  In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (PubMed:26673894, PubMed:29064368, PubMed:27918543).  In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (PubMed:27918543).  Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (By similarity).
What are the official names of this protein?
Protein adenylyltransferase FICD, AMPylator FICD, De-AMPylase FICD, FIC domain-containing protein, Huntingtin-interacting protein E.
What is the protein family that this protein belongs to?
Belongs to the fic family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: MSRA_CLOTE
Sequence: MKGVKFMKEIILAGGCFWGVEEYFSRIYGVVDTKVGYVNGVTKNPSYEEVCNGNTGYAEGCYIKFDESIIGLKRILDKFWDIIDPTILNRQGPDVGHQYRTGIYYYDKEDLDDILKSKDEISKKYDKPIVTEVEKVTYFYLAEEYHQKYLKKNPNGYCHINLDN
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: RNC_CHLAD
Sequence: MVERLAELERALGITFRDRKLLQTALMHRSLFNEQPHLLSNLSDNERLEFLGDSVLHFVTTTWLFQQFPHQNESTLTSWRAALVSTKGLAECAATLNLGQYAFLSRGEDTPKGRQRSKLLADLFEAVIGAIYLDQGLEAARAFIEPFLHERIGTLQTAVLDPTTRLQEIVQSRHKQLPKYYLIDERGPDHQREYVMAVTVEGHEYTGTGPSKKAAKKAAAQAALADIDR
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y248_BURVG
Sequence: MCHAAPAAPAGGRDAPRGGGEFSGAVRSRAVGANFEQRARQFLERRGLAFVAANVTIRGGELDLVMRASDGMLVFVEVRARRSARHGGAAASVGWRKRRRVIAAALDFWARHGAGAACRFDVVAFEAGRLDWLRDAFRADDA
What are the official names of this protein?
UPF0102 protein Bcep1808_0248.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: YDDE_ECOLI
Sequence: MKPQVYHVDAFTSQPFRGNSAGVVFPADNLSEAQMQLIARELGHSETAFLLHSDDSDVRIRYFTPTVEVPICGHATVAAHYVRAKVLGLGNCTIWQTSLAGKHRVTIEKHNDDYRISLEQGTPGFEPPLEGETRAAIINALHLTEDDILPGLPIQVATTGHSKVMIPLKPEVDIDALSPDLNALTAISKKIGCNGFFPFQIRPGKNETDGRMFSPAIGIVEDPVTGNANGPMGAWLVHHNVLPHDGNVLRVKGHQGRALGRDGMIEVTVTIRDNQPEKVTISGTAVILFHAEWAIEL
What are the official names of this protein?
Uncharacterized isomerase YddE, ORFB.
What is the protein family that this protein belongs to?
Belongs to the PhzF family.
Protein: PYRB_PSEE4
Sequence: MTPFDAKRPLQLNDQGQLRHFLSLDGLPRELLTEILDTADSFLEVGARAVKKVPLLRGKTVCNVFFENSTRTRTTFELAAQRLSADVISLNVSTSSTSKGETLFDTLRNLEAMAADMFVVRHSDSGAAHFIAEHVCPDVAVINGGDGRHAHPTQGMLDMLTIRRHKGSFENLSVAIVGDILHSRVARSDMLALKALGCPDIRVIGPKTLIPIGIEQYGVKVYTDLAEGLKDVDVVIMLRLQRERMAGGLLPSEGEFYRLFGLTTARLAGAKPDAIVMHPGPINRGVEIESAVADGKHSVILNQVTYGIAVRMAVLSMAMSGQNAQRQFDQENAQ
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL23_BORPA
Sequence: MNAERLMQVILAPIVTEKATFVAEKNQQVAFRVVADATKPEIKAAVELLFKVQVESVQVLNRKGKVKRFGRFVGRRRNERKAYVALKDGQEIDFAEVK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: TA2R1_GORGO
Sequence: MLESHLIIYFLLAVIQFLLGIFTNGIIVVVNGIDLIKHRKMAPLDLLLSCLAVSRIFLQLFIFYVNVIVIFFIEFIMCSANCAILLFINELELWLATWLGVFYCAKVASVRHPLFXWLKMRISKLVPWMILGSLLYVSMICVFHSKYAGFMVPYFLRNFFSQNTTIQKEDTLAIQIFSFVAEFSVPLLIFLVAVLLLIFSLGRHTRQMRNTVAGSRVPGRGAPISALLSILSFLILYFSHCMIKVFLSSLKFHIRRFIFLFFILVIGIYPSGHSLILILGNPKLKQNAKKFLLHSKCCQ
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 1, T2R1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RBMS3_HUMAN
Sequence: MGKRLDQPQMYPQYTYYYPHYLQTKQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSKTNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNGRPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQSTSWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMILHQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDTSGQQQQIAVDTSNEHAPAYSYQQSKP
What is the function of this protein?
Binds poly(A) and poly(U) oligoribonucleotides.
What are the official names of this protein?
RNA-binding motif, single-stranded-interacting protein 3.
Protein: PEPA_ASPOR
Sequence: MVILSKVAAVAVGLSTVASALPTGPSHSPHARRGFTINQITRQTARVGPKTASFPAIYSRALAKYGGTVPAHLKSAVASGHGTVVTSPEPNDIEYLTPVNIGGTTLNLDFDTGSADLWVFSEELPKSEQTGHDVYKPSGNASKIAGASWDISYGDGSSASGDVYQDTVTVGGVTAQGQAVEAASKISDQFVQDKNNDGLLGLAFSSINTVKPKPQTTFFDTVKDQLDAPLFAVTLKYHAPGSYDFGFIDKSKFTGELAYADVDDSQGFWQFTADGYSVGKGDAQKAPITGIADTGTTLVMLDDEIVDAYYKQVQGAKNDASAGGYVFPCETELPEFTVVIGSYNAVIPGKHINYAPLQEGSSTCVGGIQSNSGLGLSILGDVFLKSQYVVFDSQGPRLGFAAQA
What is the function of this protein?
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates.  The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site.  Shows a broad primary substrate specificity.  Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A.  Hydrolyzes bovine chymotrysinogen A between positions 'Arg-15' and 'Ile-16'.
What are the official names of this protein?
Aspergillopepsin-1, Acid protease A2, Aspartic protease pepA, Aspergillopepsin I, Aspergillopepsin O, PEPO, Aspergillopeptidase A, PEPA.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HEM3_MYCPA
Sequence: MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGDRSSGPIESLGVGVFTTALREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPARNDPRDAVVARDGLVLAELPPGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLEPVQMLPAPAQGALAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGAIAEVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVAAELFELGARELMSGARHDPARGN
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: G6PI_CYAP4
Sequence: MDATALWQRYLEWLYYHPELGIYLDVSRMRFDSAFVETLAPQFAKAFADMAALEAGAIANPDEHRQVGHYWLRAPEIAPTEELKTEIVETLEQIETFAAKVHHGQIHPTRGGLFTDIISVGIGGSALGPQFVSQSLAPERPPLDIHFLDNTDPDGIDRVLNRVEPRLSTTLVIIISKSGGTPETRNGMLEVEKRFKDAGLNFAEHAVAITSYGSKLAQIAESAGWLAIFPMHDWVGGRTSELSAVGLLPAALQGIPIREMLHGAKLMDEATRVPDLKTNPAALLALSWYCAGEGKGKKDMVVLPYKDSLQLFSRYLQQLVMESLGKEKDLQGQVVHQGIAVYGNKGTTDQHAYVQQLREGLNNFFLTFIEVLQDRQGASVEVEPGITSGDYLSGLLLGTRQALYEKQRDSITLTLPQVTPLTVGALIALYERTVGLYGFLINVNAYHQPGVEAGKKAAAANLALQKQLLRILSQEPQPISLMTLAAKVGAPEQTETIYLLLRHLAANGRGVSLQGPPEQPDRLLVRATA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNT_BLOPB
Sequence: MICKDDHSTLRARFRGFYPVVVDVETAGLDANINALLEIAVATFKMDEYGWLCVDGSLNFHIKSFPGAIIQPESLAFNGIDLNSPLRAAVTEQEALHEIFEMVRQGIKTQGCSRAIIVAHNAFFDHSFLMAAVERVSFMEKNPFHPFVMFDTATLSGLVFGQTVLAKACACAGVFFDKNKAHSALYDTERTAMLFCELVNKWKRLGGWPLTPCCIES
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: ENO_METJA
Sequence: MDERFEIKDIVAREVIDSRGNPTVEVEVITKGNGYGSAIVPSGASTGTHEALELRDKEKRFGGKGVLMAVENVNSIIRPEILGYDARMQREIDTIMIELDGTPNKSRLGANAILAVSLAVAKAAAATAKIPLYKYLGGFNSYVMPVPMMNVINGGKHAGNDLDLQEFMIMPVGATSISEAVRMGSEVYHVLKNVILEKYGKNAVNVGDEGGFAPPLKTSREALDLLTESVKKAGYEDEVVFALDAAASEFYKDGYYYVEGKKLTREELLDYYKALVDEYPIVSIEDPFHEEDFEGFAMITKELDIQIVGDDLFVTNVERLRKGIEMKAANALLLKVNQIGTLSEAVDAAQLAFRNGYGVVVSHRSGETEDTTIADLSVALNSGQIKTGAPARGERTAKYNQLIRIEQELGLSKYAGRNFRCPF
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: FTSH_LANP1
Sequence: MANNDNKHRRSMSMLLYIAVAIFVYLLLSNTLLPGLLRQQIQTVSYSEFLNKIESNEVTKVDLNTGNRNIRFTTGSGDSEKIFETTQFPNDSTLVQTLREHKVDFSASIPDNSANMLMYALIQYGIPLIIFLGIGFFINRSLKRAMGDDGPSMNFGGGFGGLGGNLGRSSAKEIKGEDTGITFKDVAGQEEAKESMQEIVSFLKTPDKYKEIGARCPRGALLVGPPGTGKTLIAKAVAGEAGVPFFQIAGSEFVEMFVGRGAAKVRDLFKQANEKAPCIIFIDEIDAVGKRRDASLNSNDEREQTLNQLLSEMDGFDNHKGIVVLAATNRPETLDKALLRPGRFDRRIPVELPDLKGREAVLQIHANDVKMEPGVDLSIVAKSTPGASGADLANIINEAALRAVRFGRRRVTTEDLTESVDVVIAGAKKKNSVLSEHEKDVVAYHETGHAIVGAIQKNDAPVTKITIVPRTSGALGFTMQVEDDERYLMSKSQAMDEIAVLCGGRAAEELIFGEMTNGASNDIERATAIARAMVTQYGMSDKLGMVTLSQQQSRYLGGGSSLTCSEATAEEIDAEVRRIVEEGHQRALQTLKENRFKLHEIAHYLQKKETITGEEFMNILKRENTFAPVDKNINDEGSSTPSEE
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: SYP_PARMW
Sequence: MRVSRLMLVTLRDVPAEAEITSHQLLLRGGFIRRVGSGIYAYLPMMWKVLQRITTIIREEMNRAGALETLLPQLHPSELWQRSGRWQGYTAGEGIMFHLEDRQGRELGLGPTHEEVITSLAGELLRSYRQLPVNLYQVQTKFRDEIRPRFGLMRGREFIMKDAYSFHADEADLQATYAVMDQAYRRIFERCGLEAVPVDADSGAIGGAASQEFMVTAEAGEDLILISDDGAYAANQEKAVSIPDAVASLPPAALTLLKTPGQTTIEGLCTAQAWQPGQLVKVLLLLAQLEDGQQQPVLVSLRGDQDLNEVKLVNAVSRRSEQGVLDCRPISPDDLQRQGINTIPFGFIGPDLADKVLADASSWTTSFLRLADTTATELEQFHCGANAEDQHRSHCSWGDLGGAPQGEDLRKARAGERCVHNPDARLQEKRGIEVGHIFQLGRKYSQALDCCFTNENGRDEPFWMGCYGIGVSRLAQAAVEQHHDDGGIRWPAAIAPYEVIVVIANNHDDAQTDLGDTVYATLLEAGIDVLLDDRKERAGVKFKDADLIGIPWRLVIGRDAAEGTVELVQRSNREMRKLPHGEAIGELLKALRP
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRNP2_PONAB
Sequence: MRWQCGTRFRGLRPVVAPWTALLALGLPGWVLAVSATAAAVVPEQHASTAGQHPLDWLLTDRGPFHRAQEYADFMERYRQGFTTRYRIYREFARWKVNNLALERKDFFSLPLPLAPESIRNIRLLGRRPNLQQVTENLIKKYGTHFLLSATLGGEESLTIFVDKRKLGRKTETTGGASIIGGSGNSTAVSLETLHQLAASYFIDRESTLRRLHHIQIATGAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKVQLLGLQVLLPEYLRERFVAAALSYITCSSEGELVCKENDCWCKCSPTFPDCNCPDADIQAMEDSLLQIQDSWATHNRQFEESEEFQALLKRLPDDRFLNSTAISQFWAMDTSLQHRYQQLGAGLKVLFKKTHRIVRRLFNLCKRCHRQPRFRLPKERSLSYWWNRIQSLLYCGESTFPGTFLEQSHSCTCPYDQSSCQGPIPCALGEGPACAHCAPDNSTRCGSCNPGYVLAQGLCRPEVAESLENFLGLETDLQDLELKYLLQKQDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHVMLALSLQICLTKNSTLEPVMAIYVNPFGGSHSESWFMPVNEGSFPDWERTNVDAAAQCQNWTITLGNRWKTFFETVHVYLRSRIKSLDDSSNETIYYEPLEMTDPSKNLGYMKINTLQVFGYSLPFDPDAIRDLILQLDYPYTQGSQDSALLQLIELRDRVNQLSPPGKVRLDLFSCLLRHRLKLANNEVGRIQSSLRAFNSKLPNPVEYETGKLCS
What is the function of this protein?
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.
What are the official names of this protein?
BMP/retinoic acid-inducible neural-specific protein 2.
What is the protein family that this protein belongs to?
Belongs to the BRINP family.
What are the subcellular locations of this protein?
Secreted.