Protein: GRGA_PENSQ
Sequence: MGSIETEGNPPYFAREPIAIVGSSCRFPGGATSPSKLWELLEKPRDVLQEIPATRFNTKAFHHPDSQHHGSTNVKHAYLLDEDPRAFDRDFFSINPKEAEAMDPQQRLLLETVYEGIESTGHSMQQLRGSTTAVFVGCMSFDYHLTAIRGIDSLPQYHGTGTAASILANRVSYFYDWKGPSVTIDTACSSSLVALHQAVSALRNGEAEMAVAAGSNLIIGPEPFVSESKLNMLSPNGRSFMWDAAADGYTRGEGFAAVFLKTLSQAIADGDHIECIIRETGVNSDGKTPGITMPSSESQARLIRDTYARCGLNPARESDRPQYFEAHGTGTQAGDPIEARAIQSVFFPNEREGQLIVGSIKTVIGHTEGTAGIAGVLKASLAVQHGQIPANLHFKDLNPKIRPYYTNLRIPTETTPWPAVSKGYPRRVSVNSFGFGGTNAHAIIESWDGAGSLTNGYALNGNTLKPLGAGPFVLSANSGAALAANAGALADYLRAHPDADLRRLAYTLFRRTDFPFRAAFSATSVEQLAEKLEAGKDSLKSSSRTATIPEVLPPRILGIFTGQGAQWATMGKELYGASSVFRSAIDQMQRALNSLPIEDRPDWSLVDQLDAPAVDSRVGEAIVSQPLCTALQVALVDVLRAAGVELSAVVGHSSGEIGAAYAAGYLDATDAIRVAYYRGFHSHLAQGPGGKRGKMMAVGMSLNQATTFCSEFGGTLTVAASNSQTSCTLAGDAEAIEDAHARLQEKGTFARVLQVDTAYHSHHMKPCAIPYLESMKQCGVTVQKGGKQCRWYSSVWGSDGRSRSFNQADGLLLEGQYWVDNMTQPVLFSQALARALNEDQYFDLALEVGPHPALKGPSAETIKMLTGLSLPYSGVLKRGQNAVTSFSDALGLLWTSFPSSRPLITFDGVRRAFPSREPLKLAVLKGLPAYSWDHPGLIWKESRTSRIFRTQSQPRHELLGHSVTHGERDKREVHWKQLLRLNELPWLAGHRIQGEVLFPASGYLSMAYEAATRLVDDRQPLRLVELHDIDIVRAMRLEQDSSGLEVVFTVRVTAQSDDCITAEVACYSGAVDSVQPLDAPQTGLTAHFTGGVRLWLGEPSTDTLPSRKTPLLPMEALDMEQLYSNLAKEGFNYADLFQAKSMHRRLNRAVVTVSSPSEPSSMRECVHPAPVDTAFQGLLAGFSFPGDGRLGTIYLPTRVECVRVNMMPSESHATVLTADATVTSTGKTTLTGDVDLFDAANARTQVQIRGIHLSAVGQRRDPWLYAGTTWARDVSYGIEPSIKTKLSEADWVLYEQLSRTAYFYLRQLRKKILPQELMLMGKYRKHMMTWVLEHLLPRIEAGEHPEIRAEWKDDTLEMVQQWRASQPSDNNDMNILHAMGKNLVGIVRGTTPPLRVLTQDGMLDRLYVEGLGARDGNHDLAGFVKQLAHQYPRMRIAEVGAGTGGTTRAVLDALGNQYASYTYTDISTGFFENARTLFGQHSSKLSFKTLNIENDPVDQGFPEGTFDMVISSNCLHATRSLGETLRHCRQLLQPGGRLVLLEITRDFLPTQLVMSTLPGWFLGIEDGRVWAPTVSLERWDELLKANGFSGVEISSTPSFCSVIVAQAVDETVQLLREPLAVAPTALPPLGDILIVGGGVTSELASQIQKPLQAAAPSNTVTVLPGLEGIEVPKGAAVLCLSDLDSPVFRDMNSKRFRGLQNVMESAEVVLWVTSGAKSGNDPDANITLGLSSTLRAERMDLRLQFLDVDEPSSVDPSMLASMLLRLAFLDPSKNDELLWVQEPELALKEGALYVPRVVSLDTLNRRSAARHRQVTQLTSVGSEDVAVVVDERQGAFELQTIPFGGATKDEICLQVLASSIRTITCDEYGPVYVCIGRDLVSGDTALALSAVNSSVVKVSEDHILYRWQDDKTTAEYTAHLHLFLVRALAEHLLGSLKGPTWIHGAPHGLREVIDVVAREQSVAVFQTTSDMAMTSDVNFIHPYANKEDLQDFRPKGLQSFINLARQEHRALSAFIHASLPASAIVNKDVASLTASLILPELRILAKQNIHDGLQVPTESVEIVAIDKVSTVTSKELGPAVLIDWSTADTINALVRPLEHRGLFAPDKTYLLCGMTGDLGISVCLWMVENGARNVVLTSRNPNISPSVLNYLSHKGATVRPMAVDITNMDSLRSAYNDIKSSMPPVGGVMNAAMVLRDRLFHHLPWEDFAAVLGPKMVGSKNLDELFGNEQLDFFVCFSSTTSIVGSIGQSAYAAANHYMASLVQQRLQRGLAGSVIHIAILTGFGYIFRRDSEHAETIYKAILPRFDRQSETDLHEMLAEAIVCGRPGSAQPAELITGIRSVFQGEWRDDPRLSCYIGQQQLQDDSSGEQAAGSVSVKDQLASAEDPAECLVILESCFALSLGNLLEIDPEQLDHNMPVANLGIDSLVAIRIREWFLREMGVDMPVLKIMSDTYSMSRMCDDALVEWRRLNKS
What is the function of this protein?
Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of gregatin A, a fungal polyketide featuring an alkylated furanone core (PubMed:32275405).  The PKS grgA synthesizes C11 and C4 polyketide chains in the presence and absence of the trans-enoyl reductase grgB, respectively (PubMed:32275405).  The polyketide transferase grgF is then responsible for the fusion of the two carbon chains to produce the furanone skeleton of gregatin A (PubMed:32275405).  Next, the cytochrome P450 monooxygenase grgG accepts performs the oxidative cyclization to furnish the gregatin scaffold and leads to the formation of desmethylgregatin A (PubMed:32275405).  Finally, the O-methyltransferase grgD methylates the carboxyl group of desmethylgregatin A to provide gregatin A (PubMed:32275405).
What are the official names of this protein?
Reducing polyketide synthase grgA, PKS grgA, Gregatin A biosynthesis cluster protein A.