PharMolix/UniProtQA huggingface dataset:
Protein: NU1C_DRANE
Sequence: MIIYATEVETINSFVRLESLNEVYGLVWIFVPIFSLVLGIITGVLVIVWLERQISAGIQQRIGPEYAGPLGILQALADGTKLLFKEDLRPSRGNTPLFSIGPSIAVISILLSYSVIPFSNHLVLADLNIGIFLWIAISSIAPIGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSLSTVDIVEAQSKYGFWGWNLWRQPIGFIIFLISSLAECERLPFDLPEAEEELIAGYQTEYSGIKFGLFYVASYLNLLISALFVTILYLGGWNISIPYISILEVFKRNPVFGTTIGIFITLAKTYLVLVISIATRWTLPRLRMDQLLNLGWKFLLPISLGNLLLTTSFQLLSL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y04_HIS1I
Sequence: MTNKKNWKCAGCKNRYSSFDKEKKDGQLKFNCPNCGHTVRRYTILGGY
What are the official names of this protein?
Uncharacterized protein ORF4.
Protein: RNPC_PENCH
Sequence: ACAATCGSVCYTSSAISAAQEAGYDLYSANDDVSNYPHEYRNYEGFDFPVSGTYYEFPILRSGAVYSGNSPGADRVVFNGNDQLAGVITHTGASGNNFVACD
What are the official names of this protein?
Guanyl-specific ribonuclease Pc, RNase Pc.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease N1/T1 family.
Protein: ERPA_LEGPL
Sequence: MASVDVSQNTSDINFSVSAADKVAELIKEEDNSDLNLRVSITGGGCSGFQYGFSFDEQINDDDTVIIQQCSDGKSSVKLLIDSMSYQYLHDAEIDYIKGIQGEQFVIRNPNAKTTCGCGSSFSIGDEDDL
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: PRIM_EHV2
Sequence: MATGRSTSTESSEKTCQQRDPLPEYRALCGTDGDAAEILTDVLTNTDSDGVVFCLAHNCYSYNIGGGEALLTLCLPAKRPWGAEKCLPVIQFRCDASRAQEFLFQGRPIPVRYIQTNLNHRAVKKFFKPILSVLTCSDKKGGGGEGAHADLKSTIFWFRAKFVAAVRKTFKITASPFWMISTFGCTEAQFVLVSSCYFFERHECTIDTLSHLSRLFDGSRGRQLTTVNTFSDLAGMFGTSAWLGRVPEFSAYVGKKLARDDLESAAVDEAVNAFRGQLMLSNADLIHYIYLSFFQCLNKEKFLEYSLRTNPHNIDGVPPEEPIITGFIDEGFKSKMATYYTKSSYLKNHVRVGSLYLDGVEGYSPEAIEAGPPAAAGGGGGADRYWAGQSRDVQGLLSDILADHPASRLSPDLHGLLDLAALGDSSGVAGGVKDSLFPEPLRCPVYRCQYLNKTFFAVVTRDNLARAWERAVQLPTQVTGWEGMEDARLTACVHYAELAFSLGHLREQLSVSRHEYFNPRLPVFNLVLDFDLPLKKPGLSLERVYSICRSVRSDVLSVLGVLGEVDEAAHPVYFFKSACPRPEWDEPYAGRPFCTCDAKLGLRIITPLPRGVAIVGGAPLVALAKILNRMIKMNREDLLEICPGLPDADGPLDTGIYHRGRCVRLPHTYKVNEACGLERLLRLFVCHPGSPDKAAYIRDAMTLRNLLHHSKSAYWEGNAREGVSEEAPQKTKVVYSVTDVSENFLVCQTQQQLPRSYERPDSRIETMTGRDLVTWVTEVAWPKVFHNIKAYIPDDKTTQFHFVKFIHTSHNIIQVKPQRGNNFVCISSNHRNKTQSVRIFIVLYTNKKDEVTITLMSQCFAHKCNSNKPRAHFSIPLQLRGRDF
What is the function of this protein?
Essential component of the helicase/primase complex.  Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis.  The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae DNA primase family.
What are the subcellular locations of this protein?
Host nucleus. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus.
Protein: SYL_SHEDO
Sequence: MQELYNPSEIEALVQKHWQEHKTFEVTEDESKEKFYCLSMFPYPSGRLHMGHVRNYTIGDVVARYQRLQGKNVLQPIGWDSFGLPAENAAINNKTSPAPWTYENIDYMKNQLKLLGFGYDWSREIATCTPEYYRWEQWFFTKLYEKGMVYKKTSSVNWCPNDETVLANEQVQDGCCWRCDTPVIQKEIPQWFIKITDYAEELLNDIDTLDGWPEQVKAMQRNWIGRSEGIEMTFKVKDSEQSFDIYTTRPDTLMGVTYVAIAAGHPLAEQAASTNPALAAFIEECKNADTTEAAMASMEKKGVATGLEAVHPISGKLVPIWVANFVLMNYGTGAVMSVPAHDQRDYEFAKAYGLEMQAVIKPADSEVDISKEAYTEKGVLFNSGTAFPELDGLEFQAAFDAIDARLTAEGKGKRQVNYRLRDWGVSRQRYWGAPIPMVTLADGTVMPTPEDQLPVILPEDVVMDGIQSPIKADKAWAETTVDGKPAFRETDTFDTFMESSWYYARYCSPHADEMLDPAKANYWLPVDQYIGGIEHACMHLLYFRFFHKLLRDAGLVNSNEPAKRLLTQGMVLADAYYYTNDKGARVWVSPLEAEVVEKDDKGRVVKAVDSQGNELVYTGMSKMSKSKNNGIDPQTMVEKYGADTVRLFMMFASPPELTLEWQESGVEGAHRFIKRLWKLASDHVAAGPTEALDVSKLSSSQKALRRELHKTIAKVSDDIGRRQMFNTAVAAVMELMNHLSKAPQDSAQDRALLAEALSAVTRLLYPIIPHMSFTLWHELGNSNNIEDSRWPDVDEAALVEDSKLIVVQVNGKVRAKITVAADATKEAVEQLGLDDEHVQKHLEGLTVRKVIYVPGKLLSLVAN
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_BURPS
Sequence: MFSVGLTGGIGSGKTTVADLFGKLGATIVDTDLIAHRITAPQGLAMPLIAREFGAEFVAADGSLDRAKMRALVFSDESARKRLEAITHPLIREETEREARTAQGAYVVFVVPLLVESGTWKTRVDRVLVVDCDVETQIARVTARNGFTRAQVEAIVARQASRDARLAAADDVIANDNASVAELAAEVAALHQRYLECAAAARN
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IKKE1_CAEEL
Sequence: MAVSPHKTYPIVITHGEKYTLFNDESIGKGAYSEVYRGRTESGRLVAVKTACKKLEVAAIGIEIEILKKLKGASNIVQYFGSNHTKMAPGSVTSETISFAMEYASSSLEAEMRRPKNHRGLSSNALIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSENSSHEMRTLVGTPNLLHPFLAHEMVDPLMAQNRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPFEHERNNKSLYHKAVVALTQNPDAIAMVLVQKGRDPGRRTDIFEFQPVTELPAKFTRYPKWLVSTMTCLLRSFFHEPSIEYYAKVADAMRNSKRRTFSSVDQMSIVEHTDMSNVPHLGFSIPSISKCLGYPEGTDILLLSNTSTHYLDSKQKSVDGLPDDLYLVVPQTSHVDMRKILARNIEFHEFDDMTDRKLSEIRIKKCYEGLSMLTEIDEYLALFDRVSTILSTQFSLLVQELSQFERVQTASRFAVYVDMASVPLMLFDEANPETKMISDQCIQQAKRAREELERHAKVSMDIEACAKQLSKDAEDLRLEDMDLPGICEEIESYVFYDKQAILSTQKYSQELVELCLKRRNNIMEQIFNSPDRINKSKLNKAMNLAASLSQLRSNYRKLQDMISECVDLLEKPFQEMKDTVNRYLQAQGCSRNTMQKSMHLLRPEFHESQIRIKKTTKSCRKLIDQLNIELDQLGFVRLGDILIKAESEQTLTRSEEIQETQVVSFFCQAESSPNKEQFPKPEQDSILESSIDEGSTSFESTPPSSPPDVGSNNYFQAVFQYFAKPTSSPSSSAK
What is the function of this protein?
Serine/threonine-protein kinase, which plays a role in regulating allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in embryos.  Phosphorylates the allophagy receptor allo-1, which is required for allophagy.
What are the official names of this protein?
Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cytoplasmic puncta in oocytes. After fertilization, localizes to paternal organelles during meiosis I and meiosis II. Co- localizes with allo-1 in embryos and oocytes.
Protein: MURB_NITMU
Sequence: MDMSEINFSLDYAGVRGELRHDQPMKNYTSWRAGGSAERIYLPGDLPDLAAFLRGLPWNEPVYVMGLGSNLLVRDGGVRGSVVVLHARLNGLQLESDMGQMLIYAGAGVACAKVARFAALQGLGGAEFLAGIPGTVGGALAMNAGCYGTETWDIVSSVQTIDRLGILRRRPPGNYEIGYRHVALKAEKSSGSQKMGARENAPDDSLTDEWFSGAWFALPRDHAAAVRQKIKELLARRIHTQPLNLPNAGSVFRNPENDKAARLIESCGLKEFRIGGAMVSPRHANFIVNTGGATASDIEAVIAAVRETVKKQTGVELKQEVRIIGTPARPELHVSRTAYRKDGGYGG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_SULIY
Sequence: MPTKARIRLWSTNVENLNYVITQIRGIVEKTGIEMRGPIPLPTSKLEVPIMRLPHGEGRKKWEKWEMRVHKRLIDIAADERVMRQLMRVRVPEDVYIEIQLI
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: HMCES_RAT
Sequence: MCGRTSCHLPRDALTRACAYLDRQGRRQLPQWRDPDKYCPSYNKSPQSSSPVLLSRLHFEKDADSSDRIIFPMRWGLVPSWFKESDPSKLQFNTSNCRSDTIMEKQSFKAPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQSKTEKSGENSGSDSLNNKEEVWDNWRLLTMAGIFDCWEPPKGERLYSYSIITVDSCRGLSDIHSRMPAILDGEEAVSKWLDFGEVSTQEALKLIHPIDNITFHPVSPVVNNSRNNTPECLAPADLLVKKEPKASGSSQRMMQWLATKSPKKEVPDSPKKDASGLPQWSSQFLQKSPLPTKRGASSSLLDRWLKQEKEDEPVAKRPNS
What is the function of this protein?
Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites.  Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue.  The HMCES DNA-protein cross-link is then degraded by the proteasome.  Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks.  Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (By similarity).  Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway.  Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).
What are the official names of this protein?
Abasic site processing protein HMCES, Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, ES cell-specific 5hmC-binding protein, Peptidase HMCES, SRAP domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the SOS response-associated peptidase family.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited to chromatin following DNA damage. Localizes to replication forks.
Protein: TAFA5_BOVIN
Sequence: MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIRTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS
What is the function of this protein?
Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity).  Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity).  Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity).  Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (By similarity).  Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity).  Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity).
What are the official names of this protein?
Chemokine-like protein TAFA-5.
What is the protein family that this protein belongs to?
Belongs to the TAFA family.
What are the subcellular locations of this protein?
Secreted.
Protein: KAD_BURCH
Sequence: MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKESDCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGHDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGTVDEIRERAFDALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_TRIEI
Sequence: MAANDTISDMLTRIRNSCMAQHTTTKVPATKMTRSIAKVLKDEGFIGEFEQEGEGIKKYLVIFLKYKGKNRQPIIRYLKRVSKPGLRVYKNRKELPRVLGGIGIAIISTSSGIMTDREARKRGIGGEVLCYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: TRPF_PSE14
Sequence: MSAVRSKICGITRIEDALAAAEAGADAIGLVFYPKSPRAVTVLQARAIIAALPPFITTVGLFVNASRCELNETLDAVALDMLQFHGDETPDECDGYHRPYIKALRVKAGDDIAQVCRTYRNARGVLLDTYVEGVPGGTGETFDWALIPDDLDKPVILAGGLTSANVAQAIAQVRPYAVDVSGGVEKSKGIKDREKILAFMSAVHGT
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: MTND_BACCR
Sequence: MAQIRIHEVNTRIENEVEVSKFLQEEGVLYEKWNISKLPTHLNENYSLTDENKAEILAIFSKEIADVSARRGYKAHDVISLSSSTPNLDELLINFQKEHHHTDDEVRFIVSGHGIFAIEGKDGKFFDVELEPGDLISVPENARHYFTLQDDRQVVAIRIFVTTEGWVPIY
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, DHK-MTPene dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
Protein: TE2_HUMLU
Sequence: MDLSSSPNHPITVVSTFASPFEGPPSVGDSNSSARKPISLWPGMYHSPVTNALWEARCKIFERLLDPPKDAPPQSELLTKTPSQSRTTILYNFSTDYILREQYRDPWNEVRIGKLLEDLDALAGTISVKHCSDDDSTTRPLLLVTASVDKIVLKKPISVDIDLKIVGAVIWVGRSSIEIQLEVSQSTKEGSNAADDVALSANFIFVARDSKTAKAAPVNRLSPETEQEKLLFDEAEARSSMRKRKRGDQERREFENGEANRLQTLLAEGRIFCDMPALADRDSILLRDTRQENSLICQPQQRNIHGRIFGGFLLHRAFELAFSTAYAFAGLVPYFLEIDHVDFXRPVDVGDFLRLKSCVLYTELHNPDQPLINIEVVAHVTRPELRSSEVSNTFYFTFTVRPEAKATKNGYRIRNVVPATEEEARRILERMDAEACI
What is the function of this protein?
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH.
What are the official names of this protein?
Acyl-coenzyme A thioesterase 2, chloroplastic, Acyl-CoA thioesterase 2, HlTE2, Acyl-CoA thioester hydrolase 2.
What is the protein family that this protein belongs to?
Belongs to the acyl coenzyme A hydrolase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GIT3_SCHPO
Sequence: MLHLDYTFNVSDATSTSSIIIVSRRELANLRIMVIIASAISIVFSLIAIFWRWSRRRTIREQFHIALFSVLFIRSIVQMIHPCLALSDPFFWAPKHRCFTIGFFLLVLVRMTDYWIFINILHNALLVLFPHVDTERRGLYRFRHTVFTLSFVIPLTIGGLAFTNKRNTFVNLQTRCYLPYTPVRFMFGLNWSFDYALSIAIIALQTCMFISIRRKIKRFKKYSHQQTNVFDTLNVIDSYPTAPDQVALPPFPDTNSTLTYTPSNSQSIYSSQSQPSPYSRPLLSSVHPNLPPGSQSTPANLNQSGIHFEQDFRDSPNRTNGLEDHTSFKLSSPLTSDEDGASSVLAAYGNDMQDDPLLKQRKRILSQSKFLFAYPAIFIFMWILPQIQIIVILAQPLHCSGSCKRFAFVAVFADNFVAIFIALSDFIWICYRGYTYLKERDSSKSYWDQIKELTLKWWRGKFGEEK
What is the function of this protein?
Activates gpa2 when triggered by glucose and then activates adenylate cyclase.
What are the official names of this protein?
Glucose receptor protein git3, Glucose-insensitive transcription protein 3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor GPR1/git3 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RN19B_MOUSE
Sequence: MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTFHSVFSASARGRRARTKPQAEPPPPAAPPPPPPPAPAPVEAQAPPVEALPSEPAAEAEAEAVAAGPEEDEAAEGGGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDSASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQVAEKEEEGNGAGGGSGGSEDDPPYKHQSCEQKDCLASKAWDISLAQPESIRSDLESSDTQSDDVPDITSDECGSPRSHAAACPSTPQVHGAPSPSAHKNLAAPAEGQTVLKSEEYEVE
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1.  Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.  Protects against staurosporin-induced cell death (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF19B, IBR domain-containing protein 3, Natural killer lytic-associated molecule, RING finger protein 19B.
What is the protein family that this protein belongs to?
Belongs to the RBR family. RNF19 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic granule membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TTCA_SALA4
Sequence: MQEIQKNTKKEQYNLNKLQKRLRRNVGEAIADFNMIEEGDRIMVCLSGGKDSYTMLEILRNLQQSAPINFSLVAVNLDQKQPGFPEHILPAYLEQLGVEYKIVEENTYGIVKEKIPEGKTTCSLCSRLRRGILYRTATELGATKIALGHHRDDILQTLFLNMFYGGKMKGMPPKLMSDDGKHIVIRPLAYCREKDIIRFAEAKAFPIIPCNLCGSQPNLQRQVIADMLRDWDKRYPGRIETMFSAMQNVVPSHLCDTNLFDFKGITHGSEVVDGGDLAFDREEIPLQPAGWQPEEDDTALEALRLDVIEVK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_LISW6
Sequence: MSQDLQKEVASRKTFAIISHPDAGKTTITEQLLLFGGVIRSAGTVKGKKSGKFATSDWMEIEKQRGISVTSSVMQFDYNGSRINILDTPGHSDFSEDTYRTLMAVDSAVMVIDAAKGIEAQTLKLFKVCRMRGIPIFTFINKMDRQGKMPLELLAELEEVLEIESYPMNWPIGMGKELAGLYDRYHRVIEQYRSEEDERFLPLGEDGDLKEAHEIQKSLYYDQALEEIMLLDEAGNDFSRERILAGEQTPVFFGSALTNFGVETFLRTFVDFAPAPSSHESNEGIIEADNPKFSGFIFKIQANMNPAHRDRIAFIRICSGEFERGMNVTLTRTGKSIKLANSTQFMADDRETVNRAVAGDIIGLYDTGNYQIGDTITNGSKKLEFEKLPQFTPELFMRVYAKNVMKQKHFHKGVEQLVQEGAIQLFKTWRTEEYIIGAVGQLQFEVFEHRMRGEYNSEIRMEPIGKKIARWVKEEDADEKLSTARSMLVKDRFDQPLFLFENEFAINWFNDKNPDIELTSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPMI_SHESM
Sequence: MTTTKRPIALLILDGWGYRENTHMNAIYHANTPVLDRLNAQYAHGLISGSGLDVGLPDGQMGNSEVGHINLGSGRIVYQELTRISKAIADHEFEQNPALCDAVDVAVKAGGAVHIMGLLSPGGVHSHEEHIEAMCRMAVARGATKVYLHAFLDGRDTPPRSAKGSLSHFDDLFTTLGHGRIASIIGRYFAMDRDNRWDRVSQAYDLITQGKAKFQYDNAVTALEAAYERNENDEFVSSSAITDSEGKVASLNDGDALIFMNFRADRARQITRSFINADFDGFERAVTPKVNFVTLTEYAADIKAPIAYPSENLVNTLGEVLQNRGRTQLRISETEKYAHVTFFFNGGKEEPFNGEDRILINSPKVATYDLQPEMSSTELTDKLVAAIESAQYDVIICNYPNGDMVGHTGNFDAAVKACEAVDACIGRVVDALAKVGGECIITADHGNAEQMTDETTGQAHTAHTSELVPFVFVGRDATIDEGGKLSDVAPTILHLMGETIPAEMTGKPLIHVKE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: LIPB_ECO5E
Sequence: MYQDKILVRQLGLQPYEPISQAMHEFTDTRDDSTLDEIWLVEHYPVFTQGQAGKAEHILMPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVNTLAELGIEAHPRADAPGVYVGEKKICSLGLRIRRGCSFHGLALNVNMDLSPFLRINPCGYAGMEMAKISQWKPEATTNNIAPRLLENILALLNNPDFEYITA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPE04_MYCTO
Sequence: MAAPIWMASPPEVHSALLSNGPGPGSLVAAATAWSQLSAEYASTAAELSGLLGAVPGWAWQGPSAEWYVAAHLPYVAWLTQASADAAGAAAQHEAAAAAYTTALAAMPTLAELAANHVIHTVLVATNFFGINTIPITLNEADYVRMWLQAAAVMGLYQAASGAALASAPRTVPAPTVMNPGGGAASTVGAVNPWQWLLALLQQLWNAYTGFYGWMLQLIWQFLQDPIGNSIKIIIAFLTNPIQALITYGPLLFALGYQIFFNLVGWPTWGMILSSPFLLPAGLGLGLAAIAFLPIVLAPAVIPPASTPLAAAAVAAGSVWPAVSMAVTGAGTAGAATPAAGAAPSAGAAPAPAAPATASFAYAVGGSGDWGPSLGPTVGGRGGIKAPAATVPAAAAAAATRGQSRARRRRRSELRDYGDEFLDMDSDSGFGPSTGDHGAQASERGAGTLGFAGTATKERRVRAVGLTALAGDEFGNGPRMPMVPGTWEQGSNEPEAPDGSGRGGGDGLPHDSK
What is the function of this protein?
Important for the siderophore-mediated iron-acquisition function of ESX-3.
What are the official names of this protein?
PPE family protein PPE4.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLMF_SHEDO
Sequence: MSKLISKQGKRPALSQSGLAKPSTSKKSSASKNANTETAKLLTKALHPRNVHKYGYDFAALSKTLPALTPFVGPNAYGNISIDFANPDAVKQLNAALLLHHYSIRDWDIPHGYLCPPIPGRVDYLHYLADLLSAPHKGKANRNIRALDIGTGANGIYPLLGIESYSWQFVASDIDKVSLDNVDEILAKNPQLAAKLSLRLQLNPKAIFNGVIEKDEYFDVSLCNPPFHRSLADANAGTQRKLSNLAKNRGQSQQQAVQAKVALNFGGQKAELWCEGGEAAFLANMISESKGFAAQCLWFTSLVSKSENLKPCYAQLAKQGTSEVKTIEMHQGNKITRILAWSYLSLSQRQAWAKLRDQSR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.