PharMolix/UniProtQA huggingface dataset:
Protein: EX7S_PSYIN
Sequence: MALKKPENMHYEEAIDELENIVNHLEVGDLALEDALKQFERGIALARSNNQKLQKAQQQVNILMQQDAQAPLQEFNDE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YDEN_ECOLI
Sequence: MKSALKKSVVSTSISLILASGMAAFAAHAADDVKLKATKTNVAFSDFTPTEYSTKGKPNIIVLTMDDLGYGQLPFDKGSFDPKTMENREVVDTYKIGIDKAIEAAQKSTPTLLSLMDEGVRFTNGYVAHGVSGPSRAAIMTGRAPARFGVYSNTDAQDGIPLTETFLPELFQNHGYYTAAVGKWHLSKISNVPVPEDKQTRDYHDNFTTFSAEEWQPQNRGFDYFMGFHAAGTAYYNSPSLFKNRERVPAKGYISDQLTDEAIGVVDRAKTLDQPFMLYLAYNAPHLPNDNPAPDQYQKQFNTGSQTADNYYASVYSVDQGVKRILEQLKKNGQYDNTIILFTSDNGAVIDGPLPLNGAQKGYKSQTYPGGTHTPMFMWWKGKLQPGNYDKLISAMDFYPTALDAADISIPKDLKLDGVSLLPWLQDKKQGEPHKNLTWITSYSHWFDEENIPFWDNYHKFVRHQSDDYPHNPNTEDLSQFSYTVRNNDYSLVYTVENNQLGLYKLTDLQQKDNLAAANPQVVKEMQGVVREFIDSSQPPLSEVNQEKFNNIKKALSEAK
What are the official names of this protein?
Uncharacterized sulfatase YdeN.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
Protein: LPXK_PHOLL
Sequence: MIERIWSGRSWLYLLLLPFSALYGLISGLRWLSYKTGLRLPWKAPVPVVVVGNLTAGGNGKTPVVIWLVEQLQKKGYRVGVVSRGYGGKAESYPLLVTENVTTAQAGDEPVLIHRRTGAPVAVAPKRVAAVKALLANTSLDIIVTDDGLQHYALQRDFEIAVIDGVRRFGNGWWLPAGPMRELSGRLNRVNTIITNGGTPQPGELSMTLAGELAVNMVSGEKRAVNLIPHAVAMAGIGHPPRFFATLQQLGADLKKEYAFADHQLYTEDQLCHLADTNQNLLMTEKDAVKCFNFAQPNWWYLPVDARLPQEKGEIMLNKICSLLETNNNSK
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: MPTA_HALMA
Sequence: MSQQLPDVQASSPDVTVGLNRVGVTGVEKLVKLGRRDRDPIVLMAEFEVFVDLPSWRKGADMSRNMEVIDETLETAVSEEAYRVEDVCGDAAELLLEKHDYTTKAEVRMEAEYVTHESTPASEMATQSTADIIASATATEDGTSEEIGARVTGMTVCPCSQGMSASRARETLKQLNVEDDVIEEFLETNPQAGHSQRGHATLTVQSDGAPEVDLNELIEVARDSMSARIYNLAKRPDEDHMTYEAHKDAKFVEDCVRALAEGVVNTFPDLPDDAVVTMKQSNDESIHQHNAHAERVAQLDDLRQEVSED
What is the function of this protein?
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
What are the official names of this protein?
GTP cyclohydrolase MptA, GTP cyclohydrolase IV.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase IV family.
Protein: ODFP1_HUMAN
Sequence: MAALSCLLDSVRRDIKKVDRELRQLRCIDEFSTRCLCDLYMHPYCCCDLHPYPYCLCYSKRSRSCGLCDLYPCCLCDYKLYCLRPSLRSLERKAIRAIEDEKRELAKLRRTTNRILASSCCSSNILGSVNVCGFEPDQVKVRVKDGKVCVSAERENRYDCLGSKKYSYMNICKEFSLPPCVDEKDVTYSYGLGSCVKIESPCYPCTSPCSPCSPCSPCNPCSPCNPCSPYDPCNPCYPCGSRFSCRKMIL
What is the function of this protein?
Component of the outer dense fibers (ODF) of spermatozoa.  ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.
What are the official names of this protein?
Outer dense fiber protein 1, Heat shock protein beta-10, HspB10.
Protein: PRIS_METMA
Sequence: MDSRTTRYLKSCFQKHYKTAEIGLPDHLPNREWAFIFYDDMPEKMMHRHKSFGSPGEALDYLYGMAPAHVYNSTAYYEYPDARKMNEKNWLGAELIFDLDADHLPNAPRNYADMLELVKKETLKLMDFLLDDFGFSEQDIELVFSGGRGYHFHITSPKVLTLGSSERREIVNYLSGRDIDFKYFFREVSMDGDFGTGSKSFKGIKNLPVKCTLVGYDSGWGKRVALYLTDYMKAECGKKYKKDMFPELRRHEKVGDTTIKKLINITNSENGLKDILERGRLDFGVRNFKEIAAYFMQESMENFLNRFGASVDEPVTADIKRLIRVPGSLHGGSGMLVKKLALCELEKFNPLNDAVVFGERPVKITVSKPFSVQLKGKDLRIEEGIQEVPEYAAVYLICRGVAEYGYRRNQPDAV
What is the function of this protein?
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  The small subunit contains the primase catalytic core and has DNA synthesis activity on its own.  Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase small subunit PriS.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase small subunit family.
Protein: HLD_STAAN
Sequence: MAQDIISTIGDLVKWIIDTVNKFTKK
What is the function of this protein?
Lyses erythrocytes and many other mammalian cells.
What are the official names of this protein?
Delta-hemolysin, Delta-lysin, Delta-toxin.
What is the protein family that this protein belongs to?
Belongs to the delta-lysin family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane. Note=In infected cells, it is found in the membrane.
Protein: PKH2_YEAST
Sequence: MYFDKDNSMSPRPLLPSDEQKLNINLLTKKEKFSHLDPHYDAKATPQRSTSNRNVGDLLLEKRTAKPMIQKALTNTDNFIEMYHNQQRKNLDDDTIKEVMINDENGKTVASTNDGRYDNDYDNNDINDQKTLDNIAGSPHMEKNRNKVKIEHDSSSQKPIAKESSKAQKNIIKKGIKDFKFGSVIGDGAYSTVMLATSIDTKKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSLDETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSVSKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEYLTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLDRRLTISQIKEHHFFKDLNFKDGSVWSKTPPEIKPYKINAKSMQAMPSGSDRKLVKKSVNTLGKSHLVTQRSASSPSVEETTHSTLYNNNTHASTESEISIKKRPTDERTAQILENARKGINNRKNQPGKRTPSGAASAALAASAALTKKTMQSYPTSSSKSSRSSSPATTSRPGTYKRTSSTESKPFAKSPPLSASVLSSKVPMPPYTPPMSPPMTPYDTYQMTPPYTTKQQDYSDTAIAAPKPCISKQNVKNSTDSPLMNKQDIQWSFYLKNINEHVLRTEKLDFVTTNYDILEKKMLKLNGSLLDPQLFGKPRHTFLSQVARSGGEVTGFRNDPTMTAYSKTEDTYYSKNIIDLQLLEDDYRIEGGDLSELLTNRSGEGYKCNQNSSPMKDDDKSESNNKGSSVFSGKIKKLFHPTSAAETLSSSDEKTKYYKRTIVMTSFGRFLVFAKRRQPNPVTNLKYELEYDINLRQQGTKIKELIIPLEMGTNHIVVIQTPYKSFLLSTDKKTTSKLFTVLKKILNSNTNKIEKELLQRNQKVIERRTSSSGRAIPKDLPTSKSPSPKPRTHSQSPSISKHNSFSESINSAKSNRSSRIFETFINAKEQNSKKHAAPVPLTSKLVNGLPKRQVTVGLGLNTGTNFKNSSAKSKRS
What is the function of this protein?
Serine/threonine-protein kinase which is part sphingolipid-mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane.  Phosphorylates and activates PKC1.  Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity.  Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step.
What are the official names of this protein?
Serine/threonine-protein kinase PKH2, PKB-activating kinase homolog 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cell cortex. Note=Localizes at eisosomes, large, immobile complexes that mark sites of endocytosis near the plasma membrane.
Protein: PSBA_PROM5
Sequence: MTTIQQQRTSLLKGWPQFCEWVTSTNNRIYVGWFGVLMIPCLLAAAACFIVAFIAAPPVDIDGIREPVAGSFLYGNNIISGAVVPSSNAIGLHFYPIWEAATVDEWLYNGGPYQLVIFHFLIGISAYMGRQWELSYRLGMRPWICVAYSAPVSAAFAVFLVYPFGQGSFSDGMPLGISGTFNFMFVFQAEHNILMHPFHMAGVAGMFGGSLFSAMHGSLVTSSLIRETTETESQNYGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAVFPVVCVWLTSMGICTMAFNLNGFNFNQSVVDANGKIVPTWGDVLNRANLGMEVMHERNAHNFPLDLAAAESTTVALTAPAIG
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: NU1M_SCYCA
Sequence: MLQTTLLYLINPLAYIIPILLATAFLTLIERKILGYMQFRKGPNIVGPYGLLQPIADGLKLFIKEPIRPSASSRSYFLATPTVALALALLMWMPLPLPHSIINLNLGLLFILAISSLTVYTILGSGWASNSKYALMGALRAVAQTISYEVSLGLILLSMIIFAGGFTLHTFNLAQETIWLLIPGWPLAFMWYISTLAETNRAPFDLTEGESELVSGFNIEYAAGPFALFFLAEYTNILLMNTLSVILFMGTSYNPLMPQISSLSLMMKASMLTVLFLWIRASYPRFRYDQLMHLVWKNFLPLTLAIILWHMALPLATTSLPPLT
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: COFC_NATMM
Sequence: MHVVVPFAADTPKTRLSEVLSPPERTALARAMLADVLSAITATGHVPTVLSTSPLSLENGCSCDDLPSTTPPGLESASDIPVTVDDRPLTAAVNAQLEAAEEPVAIVMADLALATPAALSTLFASGAADGVAIAPGRGGGTNALVVRHPDFRVDYHGASYLDHREHAAEIGAPLESVDSFRLGTDVDEPADLVEVLIHGRETAADGGESRTATRLRELGFELETTDGRVTVARDRS
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
2-phospho-L-lactate guanylyltransferase, LP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: LECG_BITAR
Sequence: NNCPPDWLPMNGLCYKIFDELKAWEDAERFCRKYKPGCHLASFHQYGESLEIAEYISDYHKGQAEVWIGLWDKKKDFSWEWTDRSCTDYLTWDKNQPDHYQNKEFCVELVSLTGYRLWNDQVCGSKNAFLCQCKF
What is the function of this protein?
Galactose-binding lectin which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids.  This is a calcium-dependent lectin (PubMed:8593494).  Shows high hemagglutinating activity (MHC is 0. 25 ug/ml on rabbit erythrocytes) (PubMed:10484740).
What are the official names of this protein?
C-type lectin PAL, CTL, BaL, Galactose-specific lectin.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLPX_XANOM
Sequence: MSEDRQGRSGDSNKILYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREELEEKAQSARSSLPKPREILEVLDQYVIGQLRAKRTLAVAVYNHYKRIESRSKNDDVELAKSNILLVGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQQGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTKNILFICGGAFAGLDKVIQQRSNDAGGIGFGAKVKSSERKQEVGKILAEVEPEDLIKFGLIPEFVGRLPVVATLEELDEPALIKILTEPKNAITKQFKKLFDMEGVELEFRADALSAIAKKALKRKTGARGLRTIVESVLLDTMYELPSQENVSKVVVDESVIEHKSEPYLIYQAQPAPAKAASGD
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: BAMA_SALDC
Sequence: MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDISNTIRALFATGNFEDVRVLRDGNTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVRVGESLDRTTLSDIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAKIQQINIVGNHAFSTEELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNIDSTQVSLTPDKKGIYITVNITEGDQYKLSGVQVSGNLAGHSAEIEKLTKIEPGELYNGTKVTKMEDDIKKLLGRYGYAYPRVQSQPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTSKDSVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKERNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYSVGINGTKNDYQTYSELSVTNPYFTVDGVSLGGRIFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYNTLRAGLGYVHNKLSNMQPQIAMDRYLESMGQSADTSSFAADDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVTIPGSDNEYYKVSLDTATYVPIDNDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTVRGFQSNTIGPKAVYKNGAHTSWDDNDDYEDCTQESGCKSDDAVGGNAMAVASLEFITPTPFISEKYANSVRTSFFWDMGTVWDTNWDPSSAPSDVPDYSDPGNIRMSAGIALQWMSPLGPLVFSYAQPFKKYDGDKAEQFQFNIGKTW
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.  Constitutes, with BamD, the core component of the assembly machinery.
What are the official names of this protein?
Outer membrane protein assembly factor BamA.
What is the protein family that this protein belongs to?
Belongs to the BamA family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: GLB4_CHITH
Sequence: MKLLILALCFAAASALTADQISTVQSSFAGVKGDAVGILYAVFKADPSIQAKFTQFAGKDLDSIKGSADFSAHANKIVGFFSKIIGDLPNIDGDVTTFVASHTPRGVTHDQLNNFRAGFVSYMKAHTDFAGAEAAWGATLDAFFGMVFAKM
What are the official names of this protein?
Globin CTT-IV.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: DLGD_ECO27
Sequence: MKVTFEQLKAAFNRVLISRGVDSETADACAEMFARTTESGVYSHGVNRFPRFIQQLENGDIIPDAQPKRITSLGAIEQWDAQRSIGNLTAKKMMDRAIELAADHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRQLPVDGGFDDEGNLTKEPGVIEKNRRILPMGYWKGSGMSIVLDMIATLLSDGASVAEVTEDNSDEYGISQIFIAIEVDKLIDGPTRDAKLQRIMDYVTSAERADENQSIRLPGHEFTTLLAENRRNGITVDDSVWAKIQAL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTN2_MOUSE
Sequence: MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEDEEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSVVRRPRPQGRSVSEPRDPPQQSGLGDSLESIPSLSQSPEPGRRGDPDPVPPAERPLEELRLRLDQLGWVVRSAGSGEDSATSSSTPLENEEPDGLEASEAGEETNLELRLAQSLHLQLEVLTPQLSPSSGTPQAHTPSPQRSQDSNSGPDDEPLLNVVEEHWRLLEQEPITAQCLDSTDQSEFMLEPLLLVADLLYWKDTRTSGAVFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLRVYRKVLQAVHRGDGTNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGTLAPTASVSGSKAKAE
What is the function of this protein?
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (By similarity).  Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity).  Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (PubMed:19720795).
What are the official names of this protein?
Reticulon-2, Neuroendocrine-specific protein-like 1, NSP-like protein 1, Neuroendocrine-specific protein-like I, NSP-like protein I, NSPLI.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell membrane, sarcolemma, T-tubule; Multi-pass membrane protein. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, cytoskeleton. Note=Localizes to intermediate filaments in mononucleated myoblasts and to Z lines in mature myotubes.
Protein: KCY_YERPA
Sequence: MTAIAPVITVDGPSGAGKGTLCKALAESLNWRLLDSGAIYRVLALAALHHQVDISTEEALVPLAAHLDVRFVSQNGQLQVILEGEDVSNEIRTETVGNTASQAAAFPRVREALLRRQRAFREAPGLIADGRDMGTIVFPDAPVKIFLDASSQERAHRRMLQLQERGFNVNFERLLAEIQERDNRDRNRSVAPLVPAADALVLDSTSMSIEQVIEQALAYAQRILALPLKK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_LEPIC
Sequence: MPKKKEDSQKTLSEKEAKGLIAKLSDEIRHHQYLYYVKNDPKISDFDFDQLFRRLQDLEEEFPQFKDLASPTLVVGSDLDKDFEKFQHKLPVLSLINTYNDNELLEWVNKTDPEGLYSVEWKIDGASIVLYYENGILKNGVTRGSGGIGDDVTDNIRTIRNIPLRLPEPITVYLRGEVFMTFKDFEEFNALSSGKYANPRNLSAGSIKQKNSSDTAKRPLRIFTYDATFPNMEKKFKTHQEIFSKLEKLTFPVPPNTAFVSGSKIAKTIQEFKKQKDSLGFPTDGLVIKLNDISKRDALGYTSHSPRWARAYKFDAIMKESKIVDITYAVGRTGKITPRAEIEPISLAGTTVTFATLHNQDYIDELGVGIGAIVRVAKRGEIIPAVEEVVTPGKEVFKIPDRCPSCNTQTIKKESLVDLFCPNPDCPDRVKNGIIFYCQRKQMDIEGLGDKQIEFLYDHDYIKSIADLYDLKDQKEKLMEEEGFGEKSVNIILKGIEQSKQKDFRFLLPSLGLSELGHKVTELLIEHGIDSIDEILSIAKDQKKIESLLEIPGIGPSTIQAFQENFSDKRILKLIERLKKAGLKMKADPIQVADQQPFAGQSWCVTGSFENFQPRDKAMDLIVYYGGRKVSAVSSKTTHLLAGPGAGSKLEKANELGVSVYDEKQFLDLLKSLKIDFKNLI
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: PAGP_SALTY
Sequence: MYVAMIIRKYFLIIALLLMPWLAIPSVSAADKGGFNTFTDNVAETWRQPEHYDLYVPAITWHARFAYDKEKTDRYNERPWGVGFGQSRWDDKGNWHGLYMMAFKDSFNKWEPIGGYGWEKTWRPLEDDNFRLGLGFTAGVTARDNWNYIPIPVLLPLASIGYGPATFQMTYIPGSYNNGNVYFAWMRFQF
What is the function of this protein?
Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.  Required for resistance to cationic antimicrobial peptides (CAMPs).  Modifications of lipid A with an acyl chain allow to evade host immune defenses by resisting antimicrobial peptides and attenuating the inflammatory response to infection triggered by lipopolysaccharide through the Toll-like receptor 4 (TLR4) signal transduction pathway.
What are the official names of this protein?
Lipid A acyltransferase PagP, Antimicrobial peptide resistance, Lipid A acylation protein.
What is the protein family that this protein belongs to?
Belongs to the lipid A palmitoyltransferase family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: NDK_RICPR
Sequence: MTIQYTFSMIKPDVIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAECFYDEHRARSFFNSLVEYITSGAVVLQVLKGEDAITLNRTIMGATNPAEAKEGTIRKDLGESIEANSIHGSDSENSAKREIKFFFSKSEIIE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BDR_BACSU
Sequence: MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNYPTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTKTQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDVVVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFGACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFNEETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH
What is the function of this protein?
S-bacillithiolation is the formation of mixed disulfide bonds between protein thiols and the general thiol reductant bacillithiol (BSH) under oxidative stress.  BSH is an equivalent of glutathione (GSH) in Firmicutes.  This protein is a NADPH-dependent bacilliredoxin reductase, which debacillithiolates (removes BSH) the S-bacillithiolated BrxB (BrxB-SSB), and to a lesser extent BrxC (BrxC-SSB).  Involved in a redox cascade increasing the efficacy of BrxB function by reducing BrxB-SSB and thus reactivating it.  Has NADPH-dependent oxidase activity under aerobic conditions producing hydrogen peroxide (H(2)O(2)).
What are the official names of this protein?
Bacilliredoxin reductase Bdr, Bacillithiol-disulfide reductase, BSSB reductase, NADPH-dependent disulfide oxidoreductase, Thioredoxin reductase-like flavoprotein, YpdA family putative bacillithiol disulfide reductase.
Protein: GIA3_GIAIN
Sequence: MSDTVTKVVADLNAAILQKSARAIAEVACKYSASDREKVRAQYRSTYSIEPDDHINKMLKGGDAATIVSNCWDELPVLRAKHLSKALKGSVDHRALLDLLIMCDREDWNNTVVAFTQQFRKNLPEELEKALKSTTSYRAFYTTWIKFDRAPRNNINGDALKLKEAFSKKDEQTVFDIMSTTVESEYKAIATQFEKVAGMTMIQAFAALTSGPLYWALHTAHYRNIGMNNGAAFLIHHACTADKKGDIARMTRLSPLLCDKCLNAKNYYSEFGDMGKDIVNAFKDAVEEVLKVLWRV
What is the function of this protein?
Giardins are involved in parasite attachment to the intestinal mucosa and in the cytoskeletal disassembly and reassembly that marks the transition from infectious trophozoite to transmissible cyst.  They may interact with other cytoskeletal proteins such as microtubules in the microribbons or crossbridges, to maintain the integrity of the ventral disk (By similarity).
What are the official names of this protein?
Giardin subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the annexin family. Giardin subunit alpha subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL22_ACIBY
Sequence: MMEVTAKLRGAAISAQKARLVADLIRGKSVAHALNILNFSNKKAAVLVKKALESAIANAEHNNSLDVDDLKVSTIYVDEGMSLKRIMPRAKGRADRITKRTCHITVKVGV
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL10_TOBAC
Sequence: CGGCEAGSAGKDAFHLRVRVHPFHVLRINKMLSCAGADRLQTGMRGAFGKPQGVCARVAIGQVLLSVRCKDGNANHAQEALRRAKFKFPRRQKIIVSRKWGFTKFSRTDYLKYKSENRIVPDGVNAKLLGCHGRLAARQPGRAFLEAVGN
What are the official names of this protein?
60S ribosomal protein L10, QM protein homolog.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: PYRC_KLEP3
Sequence: MTAQPQVLKIRRPDDWHIHLRDDDMLKTVVPYTSEFYGRAIVMPNLVPPVTTVAAAIAYRQRIMDAVPAGHDFTPLMTCYLTDSLDPAELERGFNEGVFTAAKLYPANATTNSSHGVTSTDAIMPVLERMEKLGMPLLVHGEVTHAEIDIFDREARFIDTVMEPLRQRLPGLKVVFEHITTKDAAEYVRDGNELLAATITPQHLMFNRNHMLVGGIRPHLYCLPVLKRNIHQQALRELVASGFSRAFLGTDSAPHARHRKEASCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSLNGPRFYGLPVNESYVELVREETTVVDSIALPNDSLVPFLAGETVRWTMKR
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.