PharMolix/UniProtQA huggingface dataset:
Protein: CTSRD_BOVIN
Sequence: MLVLMLVVATTFRLCPLVKARPLCRIRTLRTGKVFPVEEKIQGDRLYFSSGKTHLIKHPCKKNLALYLGRQIFLTKDTFESSLIPFSIPTSMQVGTPEVTSAHFAGSVLLLVVNQKVYVYDYEANFWTASTGIQHPVSHVSGDNCCYSGNSFCMDISNSVFAYLRGDQVSQANIYFSNSRGYRFQKYTQERRAELVGTFGGIFSFHSLSQVGLLLVDEQMAMFSYSDHPLNRSFGLPFDYDRALDILIAPGQKGILIFWSEKNLLVSRNSGQLVESVQVREGQRILYNSIVKANVTIHSVAANENELAVLTEENNLYYGSLGIQSSSLIKFADQNIWSQEAVLMFTDVGMLEILTPLRDVLFPAFDFQKCRLNIQALLMDPQLQAGVCKVELLQGEFENKMYTIDMNSQLELTALMIPRPGMLPVPLVSVSNPHSLGLQAVICEDGYTYDGNTKHRLNISLKQQHHWGRADPNFTSSIKRPTISTITLDIANKEISCVDLKPLTALISVGCDLEKKIVIQNELSACYHGVLDPVALQDNYSYIIEREAYDPNFQGQQAKKDLEVHYPYEKLGCPLLAYYDIPWKPVVELWREGKFQEVVEAEYVLLEMNGLFTYTYSLTASTAGCSAQPQNWTTITKMAGDTAPFSWDRENYISCHDPNYHEPLRWPDVPYQILGGQTENKVVFDQRNGIYIFFISIVDPSYSYCRLETTFSVYVYGAFPLSIFPPEITIVLLTAATLLSIWLAYMIPQLLHTEQGLEGNGFWVRLYQRCRKSCACLWGRC
What is the function of this protein?
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.  Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.  Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.
What are the official names of this protein?
Cation channel sperm-associated auxiliary subunit delta, CatSper-delta, CatSperdelta, Transmembrane protein 146.
What is the protein family that this protein belongs to?
Belongs to the CATSPERD family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein. Note=Specifically located in the principal piece of sperm tail.
Protein: LUXS_ECOHS
Sequence: MPLLDSFTVDHTRMEAPAVRVAKTMNTPHGDAITVFDLRFCVPNKEVMPERGIHTLEHLFAGFMRNHLNGNGVEIIDISPMGCRTGFYMSLIGTPDEQRVADAWKAAMEDVLKVQDQNQIPELNVYQCGTYQMHSLQEAQDIARSILERDVRINSNEELALPKEKLQELHI
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: WNT7A_CHLAE
Sequence: MNRKARRCLGHLFLSLGMVYLRIGGFSTVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity).  Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development.  Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity).  Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes.  Required for normal neural stem cell proliferation in the hippocampus dentate gyrus.  Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation.  Promotes formation of synapses via its interaction with FZD5 (By similarity).
What are the official names of this protein?
Protein Wnt-7a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: IAA5_SORBI
Sequence: ANWCEPGLVIPLNPLPSCRTYMVRRACGVSIGPVVPLPVLKERCCSELEKLVPYCRCGALRTALDSMMTGYEMRPTCSWGGLLTFAPTIVCYRECNLRTLHGRPFCYALGAEGTTT
What is the function of this protein?
Alpha-amylase inhibitor.
What are the official names of this protein?
Alpha-amylase inhibitor 5, SI alpha-5.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1887_SERP5
Sequence: MLKKTVLGLTAGAMLLSAGSALAADYKIDKQGQHAFIEFRIQHLGYSWLYGTFKDFDGGFTFDEKDPSKDKVNVTINTASVDTNHAERDKHLRSAEFLNVEKNKQAKFESTEVKKNGEGYAVVGNLTLNGVTKPVTLDAKLIGQGNDPWGGYRAGFEANGKIKLKDFGITTDLGPASQDVELIISVEGVRAK
What are the official names of this protein?
UPF0312 protein Spro_1887.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: CYSG_NITEC
Sequence: MDYFPVFLNIKQRNCLIVGGGSVAARKAKLLLRAGAHIHVVSPTINAEFTGLLQQFSSISHNAETFRPDHLQGRVLVIAATHDRATNQAVSVAARKAGIPVNVVDNPDLCTFIMPSILDRSPIIVAVSSGGGSPVLARLLRARLEALIPAAYGRLATYAAQFRGQVRQHFSRQENRRFFWEKMLQGPFAEMVFAGKDQAAQDYLLETLNNSVDQPPIGEVYLVGAGPGDPDLLTFRAMRLMQQADVVIYDRLVAPAILDMVRQDADRIYAGKERNRHTLPQTSINNLLIKLAQEGKRVLRLKGGDPFIFGRGGEEIETLSQHQIPFQVVPGITAASGVASYAGIPLTHRDYAHSCVFVTGHLKDNTVQLDWSALARPNQTIVVYMGLLGVSELCRQLIAHGLPKTTPAAIIQQGTTPNQCVLTGTLATLPTIIQENPLKPPTLIIVGEVVKLRQRLAWFNSTSESLGNTPGYSKHP
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: PSB28_CYAP4
Sequence: MAEIQFVRGVNEGVVPDVRLTRAKDGNTGRAVFYFDNPQLVQEGNLEIMGMYMVDEEGEIVTREVNAKFINGKATAIEAIYTIRSAPEWDRFIRFMNRYAESHGLGFNKS
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RH7_ARATH
Sequence: MPSLMLSDKKEEKKMKKKMALDTPELDSKKGKKEQKLKLSDSDEEESEKKKSKKKDKKRKASEEEDEVKSDSSSEKKKSSKKVKLGVEDVEVDNPNAVSKFRISAPLREKLKANGIEALFPIQASTFDMVLDGADLVGRARTGQGKTLAFVLPILESLVNGPAKSKRKMGYGRSPSVLVLLPTRELAKQVAADFDAYGGSLGLSSCCLYGGDSYPVQEGKLKRGVDIVVGTPGRIKDHIERQNLDFSYLQFRVLDEADEMLRMGFVEDVELILGKVEDSTKVQTLLFSATLPSWVKNISNRFLKRDQKTIDLVGNDKMKASNSVRHIAIPCNKAAMARLIPDIISCYSSGGQTIIFAETKVQVSELSGLLDGSRALHGEIPQSQREVTLAGFRNGKFATLVATNVAARGLDINDVQLIIQCEPPREVEAYIHRSGRTGRAGNTGVAVTLYDSRKSSVSRIEKEAGIKFEHLAAPQPDEIARSGGMEAAEKVKQVCDSVVPAFLEAAKELLETSGLSAEVLLAKALAKTAGFTEIKKRSLLTSMENYVTLHLEAGKPIYSPSFVYGLLRRVLPDDKVEMIEGLSLTADKTGAVFDVKQSDLDLFIAGAQKSAGSMSLEVVKVMPKLQEREPLPQKRFGGGGRGNRFGGGGGNRFGGGGGRGRGGSGGRGQRY
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 7.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACPS_BURM7
Sequence: MAIYGIGTDLAQVSRIAAVLERTGGRFAEKVLGPDELRVFHARRARSEARGIAFLATRFSAKEAFSKAIGLGMHWPMTWRALQTLNRPSGEPYVVASGELAAWLDARGITARVTVSDERDYAVTFVVAEAPDDVAAARSGAAS
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSE1_CANGA
Sequence: MPSLEVKLRKAVLAATDGKLRSDNWQYIIGVCDLVKEDPEDASQIVMEMIEKRLGQNDANVMLRSLALVVALAENCGSRLKQQVSSKHFTGILAQLLESGDVHMTVKKEIAKVVKQLSDSFKSDPSLKTMGDLNTRIRRKWPGLLEEPEKPSKQKVSHQEATDEDQELQRALKMSLEEFEKSKQQSNGSAVQSNSLQDHNQGQQQPQQQTTSGIRRVRALYDLNANEQDELSFRKGDVIVVLEQVYRDWWRGSLHGKIGIFPLNYVTPITEPSPVESQREQQIEEGVLSQAQNVQVLSAKMQMASGKGLSELNQDPEFNDLYSTVTPIRPHVTKLIGKYAKEKDDVIALRQVLLNAESTYNELLDRAAKSYSIPNTQAPPYAPAVTSQPGYVSNNTYQTTNGQYTQHNITPQQQYQVPSQNYQSQPPSMQSNHYIGYQHPGINDQPPPNY
What is the function of this protein?
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
What are the official names of this protein?
Class E vacuolar protein-sorting machinery protein HSE1.
What is the protein family that this protein belongs to?
Belongs to the STAM family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VE2_HPV44
Sequence: METIAKHLDVCQEQLLELYEENSNKLTKHIQHWKCIRYECVLLHKAKQMGLNHIGMQVVPALAVSQTKGHQAIEMQMTLETLLNSDYGTEPWTLQETSREMWLTPPKYCFKKQGQTVEVKFDCNADNAMEYVWWKVIYVFDTDKWVKVTGHIDYKGLYYVHGGHKTYYTNFEKEAEKYGNSLQWEVCIGSSIICSPASISSTVQDVSIAGPASHSSSSTTTTLAQASSTLPIGTAEDCVDAPPCKRPRGPPTNTNNARNTVCVRNSDSVDSTNNNILPNSYNSNKGRDNNYCTATPVVQLQGDANCLKCLRYRLHAKYKTLFVAASSTWRWTCSDTSSNALVTLTYVDEQQRQQFLNTVKLPPKVTYKVGYMSLQLL
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RL16_XANOP
Sequence: MLQPKRTKYRKMHKGRNDGLAWSGNAVSFGEYGLKATAHGQLTARQIEAARRTISRHVKKGGKMWIRVFPDKPITKKPIEVRMGSGKGNVEYWVAQIQPGRMIYEIEGIPEETAREAFRLAAAKLSVTTTFVTRTVR
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: HPTR_STAAM
Sequence: MFKVVICDDERIIREGLKQIIPWGDYHFNTIYTAKDGVEALSLIQQHQPELVITDIRMPRKNGVDLLNDIALLDCNVIILSSYDDFEYMKAGIQHHVLDYLLKPVDHAQLEVILGRLVRTLLEQQSQNGRSLASCHDAFQPLLKVEYDDYYVNQIVDQIKQSYQTKVTVSDLIQHIDVSESYAMRTFKDHVGITIVDYLNRYRILQSLQLLDRHYKHYEIADKVGFSEYKMFSYHFKKYLQMSPSDYCKQAK
What is the function of this protein?
Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources.  Activates uhpT expression to facilitate glucose-6-phosphate/G6P utilization by directly binding to its promoter.  Antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility.
What are the official names of this protein?
Transcriptional regulatory protein HptR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_MYCLE
Sequence: MSVEVSNESGFDVSEVELVSVARFVIIKMDVNPAAELSMVLLDTAAMADLHMRWMDLPGPTDVMSFPMDEFEPGGRPDAAEPGPSMLGDIVLCPEFAAQQAAAEGHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFALQGRLLEEWVAEQVRAYQHDRQNEKDCRLLYKSGYFGYL
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF3M_BOVIN
Sequence: MAALFLKKLTLQTVKTENYCIRRCLGKYILQGPAPTQQPPRPSCLIHAKAFSTEDTQDEMTKKKKNETAFSSVGRKINERIIHVLDEQGNDLGHMHRANVIRLMAERDLRLVKRDASAEPPQYQLLTGAQIHQERLRLREAERAAPKPGPTLTKELTFSSNIGQHDLDTKSKQIQQWIEKKYKVQITVKKGKSADEPEDKMEEMCNRIVQTMSGIATFSSRPQPIRGGKAVMCVLRPLSKKEEAAWKAAPDTPRRDALNGGDGKDGASGVLPQ
What is the function of this protein?
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3, mitochondrial, IF-3(Mt), IF-3Mt, IF3(mt), IF3mt.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SMU1_DICDI
Sequence: MSNPTSTTHHNIEIQSQDVIKLILQFLKENSLGNSLTALQEETGINLNAVDSKETFLNDVKNGNWDSVLTVVSTLRLSTTLLMDLYEQIVELLHLKEYELCKYLIRKTEPLNYMKLNQQERYLKLENHLQREYIDLGDFYKYGITTEKRRKQLIEQLNNEIITVPSSRLLSLLSQSLHWQKHQGIIPDDCMEFDLFKGEVPFKKIESEEEQITTVLDKTIKFNNKNKPETIKFSPDSKYLLTGSMDGFIEVWDYNTGKLSKSLAYQSNDDFMMHDDAILCIAFSKDGEFLATGSLDNKIKVWQIKSGKCLRKFEPAHTNGVTCLQFSRNSTQILSGSFDSSLKIHGLKSGKALKIFRGHQSFVNDCCFNHDEDRVISCSSDGKIKIWDAKSSDCLQTITPTSVVTVRDISIRSITILLKNPEFLLVCNSSQISIVSMKSQTISKTFTSENSKTFLVCTLSPLQNYLYAVDEDNILYTFDFNSGSLLNKFKIHDQEVISISHHPTKNLLATTGSDCLLKIWKSNSNDNINN
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the spliceosome.
What are the official names of this protein?
WD40 repeat-containing protein smu1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SMU1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle.
Protein: SEC31_DICDI
Sequence: MSKLKEISRQSTTSWSPIAQYPDYMAVGTVTGTIGADFDTSSKLEIYSLDITNESKQMTLKGSTSSSTRFNKVVWGQASSNFQNGIIAGAMDNGTINLWDPTKILASDATDGGGSDDQSSLIGVGQRHSGPVQSIDFNVQNPNLLASGGSDSEVFIWDLSDPTQPSALNPGSKSQQSSDITCVAWNKKVAHILGSASYNGYIVIWDLKSKKTLMTINDRNRKCKYRSIVWHPSEATQIVAASEDDDHPVIQAWDLRNTTSPVKSMEGHKKGVWGLSWCPSDNALLLSTGKDNKTFCWNFDRQEILCEINDNNSRNNINNNSNNSNSDNNNGNTDPNAWNFEVQWSPRVPALLSTSSYVGKVNVYSLQDVNEKSTSGSSAGQLNALGIQEQTSQITPTIKHTPNWLLRPCGAAFGFGGKIAVFGRNKKVTAAANGATSPSSSSSPASSVQQSQLQQQQRVIHISHVTTEVDIVKSSEQLENVIHTGQYEQYCQEKIDQSTSDEEKSIWGFLKVKFAKDDRLKILDYLGYDIETIKKELKQFLGTLPELPIESGFNELPIENVDDQSKPEPTTTTTNETVHLEPVVDENNNVVDADSFFDTAASDANKEQQDDSSSSPSTKSPTTTTTPIEFPGDEKEQMITKALLVGDHNSAVECCLRLGRYSDALILAHAAGQELWKKTQEAYFEIVRSPFGRVVSCIVKRDFQLLVKSADLKDWKASLAILCTYAPPTDFKILSGILGDRLDKEASDLKSAILCYICAGDIDKTVDIWSRVSQQHQQQQRQSLTSSGNSITVLEQESNKDLQNLIEKVSIFRSACNGNSNNNTLNQVLSMKYAKYAEILASQGNLSASLRYLAPITNSQCKQEYGVLFDRVYRATSNHQGIPQPPFPFQLVDVYSSNQPIQQQQQQQQNKAQQVGHQHQHQHQHQNQHQHQHQHQHQHQPPQQQQQQQQQQQMGRQNTFNQPPQPMGQHQHQQQQQQQQPPIMMNQSPMQNNNNNRIPMMNQPPMMNQPPMMNQPPMMNQPPQMMNQPPQMMNQPPPQMMNQPPPQMMNNNQPPIMMRPMQPSGPSPMNPPPTMNNTQPPPMMNTMGGPSSVNNSQPPIIPMNGNPLPMNPMSPMMSDKSNQPPMNPMMNPMNPMNPMMNPIQPTAPPPMNPMIPQGGSPMINHPPPPMNPMINNGPVSTPPMNPMMNQVVPQNISPPQMPTRSPVLENKSSSPSSESFTSPAPKPNVHNKTPSIITGQLGVTTPSEGPSNEDTERFVEKLQRSIQELNGRTDSKVWEDANKRCQGLINKVSKKDISAEAFKALDAILASIVEKDFKKASDTYIQITSTPLWGEVGSQSMVGLKRLIDLGLKSH
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC31.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC31 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SNUT2_PONAB
Sequence: MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDFEKLCSISPSHVNAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHENTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQGA
What is the function of this protein?
Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome.  Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint.  Does not have ubiquitin-specific peptidase activity.
What are the official names of this protein?
U4/U6.U5 tri-snRNP-associated protein 2, Inactive ubiquitin-specific peptidase 39.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EFTS_SINFN
Sequence: MTVTAAMVKDLREKTGAGMMDCKKALAETNGDMEAAIDWLRAKGIAKADKKSGRTAAEGLIGIASAGNKAVVVEINSETDFVARNDAFQDLVRGIANVALGTDGTVEAVSQATYPATGKSVEDSVKDAIATIGENMTLRRAAALKVEDGVVATYIHNAAGDGIGKLGVLVALKSTGNKEALNAIGRQVAMHVAATNPLAVRPSEIDPAVAERERNVFIEQSRASGKPDNIIEKMVDGRMRKFFEEVALLSQAFVMNPDQTVEAAIKEAEKTVGAPIEVAGIARLLLGEGVQKEESDFAAEVAAAAKG
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_AGARV
Sequence: MGKVVVMDHPLIQHKIGIMRRTDTGSKDFRTLVSEVAMLECYEATRDLELTDVEIETPICKATVKELKGKKLAVVPILRAGLGMVEGMLELIPAAKVGHIGMYRDPETAEPIEYYCKLPADCANREVFVVDPMLATGGSAVAALDMLKKRGVKNIHFMCIIAAPEGVKRLTEAHPDVDVYIGALDDHLNEHKYIVPGLGDAGDRIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: PUR5_CHRVO
Sequence: MNTTSLSYRDAGVDIDAGDALVENIKPFAKRTMRPEVLGGIGGFGALVEISKKYKEPVLVSGTDGVGTKLKLAFDWNRHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVAQATEVIKGIAAGCEQAGCALTGGETAEMPGMYPAGEYDLAGFAVGVVEKSKVISGRDIVPGDVVLGLASNGVHSNGYSLVRKIIDRAQPELDAPFDGDKTLRDAVIAPTRIYVKPLLKLMETLPVKGMAHITGGGITENTPRVLPDNTVAQIDAASWQLPKLFQWLQREGNVDIQEMYRTFNCGIGMVVVVAPEHAEQALALLREAGETVYRIGQVRERQGGEHQTQIA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLJ_ORITI
Sequence: MNKLDISTINIEQLTSDHAKKIVDFLALELQKYDQAYYSDNNPLVTDAQYDVLKNLNNKIVAKFPHLALVNDHSKKVGFTPSAQFSKVVHLKPMLSLANGFCVEDISNFITKIQNFLKIDHCPKIVCEYKIDGLSFNARYEYGVLTLASTRGDGQIGENITENLKTIQSFPQTLPITDKVFEVRGEIYITNNDFRVLNIQQQKLGKALFSNPRNAAAGSIRQLDPAITAQRPLKYFVYALGEVTNHHFASTQFELLQKLSQLKFSVNTDYILSDNLHSMIEFYNNVATERNNLAFEIDGVVYKVNDFALQERLGATSTSPRFAIAYKFPALIGRTKITNITLQVGKTGAVTPVAWLIPINIAGVTISRATLHNKQEIESKDIRIGDYVFLHRAGDVIPKINGVDLSARDTQSSERFIFPTTCPSCNQNLVVNEGETVARCGNSLACQAQIYERICHFVSKDALNIDGLGKQRIQFLLDNKYIVNIVDIFLLEENNKFLYSNKLEDIAGWGIKSVNKLFQNINQAKNVILDKFIYALAIKHVGKYSAKLLAKEFKTAKNFINQSLKLANNATEIYEKLRNIEGVGVKTADQLKQFFMVSANVNLITKLVNILTIQDWQYHGDNLLLSNQTIVFTGTFATVSRSEIKVQAEKLGAKVGTQVSNNTDLLVVGNKAGNKLQKAQQLGIKIINEEEWIKMVNEL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: KDSB_BRADU
Sequence: MTDPRILVLIPARMAATRLPGKPLADIAGLPMIVHVLRRAEAAGIGRVAVATDTPEIAAVVAAHGGEAVMTRTTHPSGSDRIHEAMQKLDPEGKAEIVINLQGDFPTITPQTIREVLPPFADPAVDIVTLASQIHTEEEDLAPSVVKAVGSPIGPRRLRALYFTRATAPYGNGPRYHHIGLYAYRRAALERFVSLPPSPLELQESLEQLRAVEAGMRIDIMIVDSVPRGVDTPPDLETARSILSKS
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSD_SALPK
Sequence: MDQKRLTHLRQLETESIHIIREVAAEFANPVMLYSIGKDSSVMLHLARKAFYPGTLPFPLLHVDTGWKFREMYAFRDRTANAYGCELLVHKNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWRNYNGQINKGESIRVFPLSNWTEQDIWQYIWLENIDIVPLYLAAERPVLERDGMLMMVDDDRIDLQPGEVIKKRMVRFRTLGCWPLTGAVESHAQTLPEIIEEMLVSTTSERQGRMIDRDQAGSMELKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: GATB_MYCA1
Sequence: MSVAANAELMDYDDVIARFDPVLGLEVHVELSTVTKMFCGCTTAFGAEPNTQVCPVCLGLPGSLPVLNQAAVESAIRIGLALNCEIVPWCRFARKNYFYPDMPKNYQISQYDEPIAINGYLEAPLDDGTTWRVDIERAHMEEDTGKLTHIGSETGRIHGATTSLIDYNRAGVPLIEIVTKPIVGAGERAPQIARAYVTALRDLLRALGVSDVRMDQGSMRCDANVSLKPIGTAEFGTRTETKNVNSLKSVEVAVRYEMQRQAAVLASGGRITQETRHFHEAGYTSPGRVKETAEDYRYFPEPDLEPVAPSRELVERLRLTIPELPWLSRKRIQQEWGVSDEVMRDLVNAGAVDLVIETVKHGAPSEQARAWWGNFLVQKANEANIGLDELNISPAQVAAVIALVDEGKLSNKLARQVVEGVLAGEGEPDQVMNARGLELVRDDSVTQAAVDEALAANPDVAEKIRGGKIAAAGAIVGAVMKATRGQADAARVRELVLAACGQG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.