PharMolix/UniProtQA huggingface dataset:
Protein: PUMP3_ARATH
Sequence: MERSRVTREAPTGTRILLASLSAMVAESVTFPIDLTKTRMQLHGSGSASGAHRIGAFGVVSEIARKEGVIGLYKGLSPAIIRHLFYTPIRIIGYENLKGLIVRSETNNSESLPLATKALVGGFSGVIAQVVASPADLVKVRMQADGRLVSQGLKPRYSGPIEAFTKILQSEGVKGLWKGVLPNIQRAFLVNMGELACYDHAKHFVIDKKIAEDNIFAHTLASIMSGLASTSLSCPADVVKTRMMNQGENAVYRNSYDCLVKTVKFEGIRALWKGFFPTWARLGPWQFVFWVSYEKFRLLAGISSF
What is the function of this protein?
PUMPS are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation.  This leads to a decrease in the efficiency of oxidative phosphorylation and an increase in heat production.  May be involved in protecting plant cells against oxidative stress damage (By similarity).
What are the official names of this protein?
Mitochondrial uncoupling protein 3, AtPUMP3.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RSSA_DROTE
Sequence: MSGGLDILSLKEDDITKMLVATTHLGSENVNFQMEQYVYKRRADGVNILNLGKTWEKLQLAARAIVAIDNPSDIFVISSRPIGQRAVLKFAKYTDTTPIAGRFTPGAFTNQIQPAFREPRLLVVTDPNTDHQPIMEASYVNIPVIAFTNTDSPLRYIDIAIPCNNKSAHSIGLMWWLLAREVLRLRGTISRSVEWPVVVDLFFYRDPEEAEKEEAAAKELLPPPKIEEAVDHPVEETTNWADEVAAETVGGVEDWNEDTVKTSWGSDGQF
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.  Required during oogenesis and imaginal development.
What are the official names of this protein?
40S ribosomal protein SA, Protein stubarista.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=May associate with nascent RNP complexes within the nucleus.
Protein: PREP_NEUCR
Sequence: MLRNATKGAARRAVTELSQYPKPGEKLHGFTLLRSKHVPELELTALHLQHDKTGAEHLHIARDDSNNVFSIGFKTNPPDDTGVPHILEHTTLCGSQKYPIRDPFFKMLPRTLSNFMNAFTASDHTFYPFATTNAQDFKNLMSVYLDATLHPLLKETDFTQEGWRIGPENPQALVAAEGNAKPEDRKLVFKGVVYNEMKGQMSDAAYLFWIRFQDHIFPDIHNSGGDPQKITDLTYQQLKKFHADHYHPSNAKVFTYGDMPLADHLKEIGAQLDVFEKIRADVAHHSPIDLSSGPREVKLYGPIDPLVDANKQFKTSVSWVLGETNNVVESFSLALISALLMDGYGSPLYKGLIESGLGTDWSPNTGYDSSGKLGIFSIGLSGVQEEDVPKVKAKVQEILRSMRDKGFERSKIDGYLHQLELGLKHKTANFGMSLLHRLKPKWFVGVDPFDSLAWNDTIAAFETELAKGGYLEGLIDKYLINDNTLSFTMAPSPTFSQELAQEEETRLSTKISEVVKAAGSEEEARAALEARELKLLAEQSKTNTEDLGCLPSVHVKDIPRQKDSVILRHDNTARVKTQWHEAPTNGLTYFRAINQLENLPDELRSLIPLFTDSIMRLGTKDMTMEQLEDLIKLKTGGVSVGYHSASHPTDFTRATEGLMFSGMALDRHVPTMFDLLRKLVVETDFDSPQAAQQIRQLLQASADGVVNDIASSGHAYARRAAESGLTWDSFLKEQVSGLSQVKLVTSLASRPESDPLEDVIAKLKQIQQFALAGNLRTAITCDSGSVSDNAKALLNFVNSLPSEAVTFPSRGPPNFTRDIKTFYPLPYQVYYGALALPTASYTASVNAPLQILSQLLTHKHLHHEIREKGGAYGGGSYARPLDGIFGFYSYRDPNPVNTLKIMRNAGQWAVDKEWTDRDLEDAKISVFQGVDAPKAVNEEGMAQFLYGITDEMKQKRREELLDVTKDQVREVAQEYVVKALNNGSERVVFLGEKRDWVDKSWAVKEMDINGST
What is the function of this protein?
Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity).  Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity).  Also degrades other unstructured peptides (By similarity).  May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (By similarity).
What are the official names of this protein?
Presequence protease, mitochondrial, PreP, Pitrilysin metalloproteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family. PreP subfamily.
Protein: Y2786_FRACC
Sequence: MGVVRSLLLFVVAAVTEIGGAWLVWQGVREHRGPVWVGLGIGFLAAYGFVATLQPDAHFGRILAAYGGVFVAGSLLWGVAVDGFRPDRYDLAGAAICLLGVAVIMYARRV
What are the official names of this protein?
UPF0060 membrane protein Francci3_2786.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ADPRS_DANRE
Sequence: MSAAARVVAPVMMLSRFRGALVGSVLGDCIGGEFEGAVDVPLDRVLQHLSALEDDTRGDGILQYSDDTAMMRCVADSLLTRMTFDERDMAQRFAKEYSHSPGRGYGSGVVQVLRKLASPHLKDVFQPAQAQFGGRGSFGNGGAMRAVPFALAFRSRADVRKYSRFGAMLTHSCSLGYNGAALQALAVHLSLQGALALPKDFIDKLISEMEELEKDETAKHDAKALNLSEFPYCSRLHRVKELMDKTSVSIEEVISELGNGIAALQSVPTAIFCVLYCLEPQDGLPERFGGLERTIAYSLALGGDTDTIACMAGAIAGAHYGIDSIPLSWQVSCEGVDEADDLARRLYDLYCLPQHNEDRGNNQPHTTNTD
What is the function of this protein?
ADP-ribosylhydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose.  Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response.  Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage.  Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds.  Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos (By similarity).  Also hydrolyzes free poly(ADP-ribose) in mitochondria.  Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins.  Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
What are the official names of this protein?
ADP-ribosylhydrolase ARH3, ADP-ribose glycohydrolase ARH3, ADP-ribosylhydrolase 3, O-acetyl-ADP-ribose deacetylase ARH3, Poly(ADP-ribose) glycohydrolase ARH3, [Protein ADP-ribosylarginine] hydrolase-like protein 2, [Protein ADP-ribosylserine] hydrolase.
What is the protein family that this protein belongs to?
Belongs to the ADP-ribosylglycohydrolase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Mitochondrion matrix. Note=Recruited to DNA lesion regions following DNA damage; ADP-D-ribose-recognition is required for recruitment to DNA damage sites.
Protein: Y1561_METJA
Sequence: MITNKIKIFLISLIFISGVYALQVDAPQYQPNVIHPGDDVDLWIKITNDNYDNEVKNIVVEVSPHYPFELRQVNPIKGKATISHLNPGESDTVYFKLHVDENAPSRDYEIDVKVSYDEINKEDGKETIHHYEITKIYYLHVYGIASFEINGNFSLIPSKTQTVPIEIINTGTGTAKEVNLYIGYSLNSVNAGSESVEVSAYGTTKTQEKTIYYPTAVPISNLPISPVGETKFYLGALKPDNSRVINLKLYTASNLVEGCYQIPAVITWIDEDGTKRAEQITIGAYVKGDILLGISNVVTDPKEIKPGTTYVRIDVTITNNGHAEAKDVKLKLITNKPFKDSWSNCNIKDVGNLLPGVSKTVSFYVDVDKYASAKHYKLPIEISYLDTANNKYKTEKFIDIYVKPKPLFEIITKEVNVTAGKENTVYITIKNVGSEKAERVKISAIRNSGQPFDYPIKSDTIGTLYPNQTGTGVIVIDVDKNAESKPYIITIEIRCAGDSDEGDNNVYVYQEPLKVVVNNSNSKSYWILGIIVVIAIVLVVGYVFKRKNSKDKE
What are the official names of this protein?
Uncharacterized protein MJ1561.
What is the protein family that this protein belongs to?
To M.jannaschii MJ0795 and MJ1506.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GUF1_CAEEL
Sequence: MPRRRLLKLLFIGKLRVSCKHYSTAGDPTKLVNLSEFTPDKIRNFGIVAHVDHGKSTLADRLLEMCGAVPPGQKQMLDKLQVERERGITVKAQTAALRHRGYLLNLIDTPGHVDFSAEVSRSLAVCDGILLLVAANQGVQAQTIANFWLAFEKNIQIIPVINKIDLPGADIKSVETQLKNLFEFNPEECLHISAKSGLNVDKVLEAIIDRVPAPTAIIDAPFRSMIFDSYFDHFRGAIAHIMVKEGSVKKGDKIQSYQNEKVYDVSEVGVMRPEMVKCTELRAGQVGYLVCNMRTVNEAVVGETLFAETTSRDSVKTFAEIKGVKPTVYAGLFPVETSDYESLKQAVERLCLNDPSVTVIPDSSKALGLGWRIGFLGVLHMEVFGARLSQEYDASVILCQPSVEYRAKIKDNETIRKKRYDGMEEIRILDPSKFPDESDVDSFLEPMVKVRMIVPNEMMGTVNGLCSECRGERGEITSIDSTRLVILWRLPLAEVAVDFFERLKKLTSGYASFDYEPDGWQDTRLVKLTILINSKEVSEFSQIIPAAMARDRAKILVQRLKREIPRQQFEVTIKACIGSSTKALSQIVIQPMKRDFSQLLKGNFGGGGMERLNKKLSHQKKGKERMKMVGNVQIPKEAFLNVLKR
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1 homolog, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1 homolog, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: LPXA_BRUME
Sequence: MKETFIHPTALVEPGVELGQGVSVGPFCHVQSGAIIGNDCELMSHVVITGATTLGAGTKVYPHAILGCDPQNNKHKGGPTRLNVGVNCIIREGVTMHKGSDNARGYTSIGDNCSFLAYAHVAHDCDIGDYVTFSNNVMIGGHTSIGHHAILGGGAAVHQFVRVGHHAFIGGLAAVVSDLIPYGMAIGVHAHLGGLNIIGMKRSGMERKEIHNLRHAVRMLFDRTKPIRQRAQDVLAAIPDSPTVSDMISFINVDTKRAYCTPPLDAAHGGAGHDSDED
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_ECOSM
Sequence: MAVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: GATB_DEHM1
Sequence: MTQYETVIGLEVHVQLNTKSKMFCRCSTDYTSAEPNTHVCPVCLGMPGVLPTINKQAVEYTIMSGLALGCDIASFSKFDRKNYNYPDLMKGYQISQYDQPLCGKGFMDINIDGAIRRIGITRIHLEEDVAKLHHESDINGQPYSLLDINRSSIPLMEIVSEPDMRTPEEARQYLMKLRTIMRYLGVSTANMEDGSFRCDANISIRPEGSPELGAKVEVKNMNSFKAVFSALEYEEVRQRKMADEGKKISQETRGWQDDKCQTVSQRSKEFAHDYRYFPEPDLPPLHISCDWIEAIRAKLPELPEVRKERFIQGYWLSEYDASLLTASRELADYFEAVLSEADFQNIPQDKGIKEVANWVVGPVSSIMNTAGADINAFTLKVSPASLCRLLVLVSAGKVNAATAKAVLEDMYSTGQNAETIIEKKGLSQISDSSELVSIAKKVLADNPKAVAEYNEGKTQVIGFLVGQMMKQSKGRANPNIAMELLKKALEEG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: RS14_AERHH
Sequence: MAKTSMKAREAKRAKLVAKFASKRTELKAIIVDMNASEEARWDAVLQLQQLPRDSSPSRQRNRCNITGRPHGFLRKFGLSRIKVREHAMKGEIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: DDC_DROSI
Sequence: MSHIPISNTIPPKQTDGNGKANISPDKLDPKVSIDMEAPEFKDFAKTMVDFIAEYLENIRDRRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKMLELPAEFLVCSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSSVERAGLLGGVKLRSVQSENHRMRGAALEKAIEQDLAEGLIPFYAVVTLGTTNSCAFDYLDECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDPLYLKHDMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSRFELAAEINMGLVCFRLKGSNERNEALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFTQSEDMEYSWKEVSAAADEMEQEQ
What is the function of this protein?
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) to dopamine and L-5-hydroxytryptophan (5-HTP) to serotonin.  Catalyzes the formation of serotonin more efficiently than dopamine.  Displays no activity to tyrosine.  Variation in the synthesis of bioamines may be a factor contributing to natural variation in life span.
What are the official names of this protein?
Aromatic-L-amino-acid decarboxylase, AADC, DOPA decarboxylase, DDC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family.
Protein: RM13_DROME
Sequence: MSIAKRVQQWATFARTWHIYDCTWQNPFESAKLVKTHLLGLQKPIYHPMNDCGDHVVLINTREIALPGDEWVKRVYFHHTGYPGGASWTLAWQLHEKDPTMVMKKAVYNSMRGNLQRRHTMQRLHLFADDQVPEEILQNVTNQIRTPRSIPQRLDHIDKETLENFPNIMDYPKDYILR
What are the official names of this protein?
39S ribosomal protein L13, mitochondrial, L13mt, MRP-L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TNA1_YEAST
Sequence: MSNKFTMESPKHLVDDVLFISPTNDGSEEKPTEVTFQEDEGHDASLHNRSHDKKSELATEREIMATTTDDDGIPSPSHPMEKRVLRKMDIYLIPLMGMLYFLSNLDKSNIGNAEVAGLSKDIHLVGTQYNTCVTVFFATYVLFDPIGTNLLKIMGPPLMMSICLTCFGAISLGTAWVKNYAQLIVVRLLLGAFEGMIYPAINMYLSVCYRREQYALRFAFVFSAACLSSSFGGLIAYGCSKISGSLKDWQYIYIVEGCISLGFVPFYAFGLSKNLEDSWFFNKEEKEYISERYKTMNTFDPDEKFEWFQVWQAVKDVKTWASAVALFGIDLTTFGLTVFLPIIITSMGFTNVRAQLMTVPIYFLTAIVFFICAVWSDRIKLRSPFILGACLTTSIGIAIVLGSQVHGVRYFGVYILCMGIYVNAACNCLWLSGNTGNYFKRATALGINLFFGSGSGLVSGQIFVAKDKPRYIKGLSISLAFQVFSIFMTVVQIFLYKRENDKKKAIIDRCNELGEPIPYDERLSDKNPEFKYMY
What is the function of this protein?
Involved in the uptake of nicotinic acid.
What are the official names of this protein?
High-affinity nicotinic acid transporter, Nicotinic acid permease.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Allantoate permease family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: COMB_THEP1
Sequence: MVDVVMAPCSPVECRTAVVIDVLRATSTIVTALSNGASGVIPVKTIEEALKKRKEGVLICGERNAQKPKGFDLGNSPLEYRKEKISGKTIVLTTTNGTQVIERIRSEEIIAASFLNLSAVVEYLKSKEDILLVCAGTNGRFSLEDFLLAGAVVKRLKRNDLGDGARAAERYFESVENTREEIKKHSSHAKRLISLGFEKDVEFCTTEDLFKTVPTLVNGVFILKEFP
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: RL15_BURL3
Sequence: MELNNLKPAAGAKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFTSLTKEFVGEVRLSDLEKLPVDEIDLLALKQAGLVGELTKSAKIIATGELKRKIVVKGLGATKGARAAIEAAGGSFAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: FRDC_ECOSM
Sequence: MTTKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGFVDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKMGPEPIIKSLWAVTVVATIVILFVALYW
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth.  Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.
What are the official names of this protein?
Fumarate reductase subunit C, Fumarate reductase 15 kDa hydrophobic protein, Quinol-fumarate reductase subunit C, QFR subunit C.
What is the protein family that this protein belongs to?
Belongs to the FrdC family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRI50_HUMAN
Sequence: MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLSPEQPTKL
What is the function of this protein?
E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308).  In turn, promotes starvation-induced autophagy activation.  Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322).  Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM50, RING-type E3 ubiquitin transferase TRIM50, Tripartite motif-containing protein 50.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins.
Protein: PURA_CAMHC
Sequence: MSKADLIIGSQWGDEGKGKIVDMLCANYDYVCRSGGGHNAGHTIWVDGVRYAMHLVPSGILHENIINIIGNGVVVNPDVLIAEMAQFKNLKGRFFISEKAHLNLEHHSLIDQAKERAKGDKAIGTTGKGIGPAYADKVNRTGHRVGELLNPEKLCENLMKEFDENAKFYDALNIKIPEKIAVFNELKRFKEFLAPYIANTTEMLWKALDENKKVLVEGAQGSLLDIDHGTYPYVTSSNTVASGACTGLGLAPKDIGEVIGIVKAYTTRVGNGAFPSEANDEWGEKMCQIGKEFGTTTGRKRRCGWFDAVCVKYSARLSGIDKFALMKLDVLDGFEKVKICTAYKLNGEIIDYFPCNLESVEPVYEEMDGWDSIKGVKKFSDLPENAQKYIKRIEELTNMRAGFISTSPERDDTIIL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_SHEWM
Sequence: MRLNTLSPAAGSKSAAKRVGRGIGSGTGKTCGRGHKGQKSRSGGGVRIGFEGGQMPLKIRLPKFGFTSRKAMVSAEVRISELAKVNGDVVDLSTLKDANLVTRNIQFAKIVLSGTIERPVTVKGLKVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GPDA_GEOSL
Sequence: MSERIGVIGAGSWGTTLANLLARKGLDVTLWAYEAELVEEMRATRVNSLFLPGIELAPALSFTNSLEEAATGKDFLVLVSPSQVMRGVLAQLAPLLRPGVVLVNASKGIELDTLMTMDQVCAAVLPPEVARCFSVLSGPSFAREVSLEMPTAVVAASGDPAVAAAVQRLFTTPSFRVYTNTDVVGVEIGGALKNVIAVAAGISDGLGLGHNTRAALITRGLAEMTRLGLSMGAQPETFAGLAGMGDLVLTCTGDLSRNRTVGMKLGQGMKLADVLGEMRMVAEGVKTAESAYRLARRTGVEMPITEKVYQVLHEDKPARQAVMELMTRDLKAERW
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y766_EDWI9
Sequence: MDYEFRHDIGGQVIALFSMGHEAVGHWLNEEVKGDLALLSRIEQEAAALKGSERQWQLEGHEYTLWLDSEEVMVRANQLALESDELDDGMRYYDEESLSLCGLEDFLQVLTRYRSFIQQH
What are the official names of this protein?
UPF0231 protein NT01EI_0766.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: PANC_SHESH
Sequence: MITTQEISQIRQQVRAWHAKGETVAFVPTMGNLHLGHITLIKEAVKRADHVVASIFVNPMQFGQNEDLDAYPRTLAADQQALSDAGAELLFTPTPEIIYPKGMEQQSFVEVPNISEQLCGASRPGHFRGVATVVCKLFNIVQPDIALFGRKDFQQLLVIETMVADLSMPIEIIGVDTIREASGLAMSSRNGYLSQDQKDRAATLKRTMDTMSAAIQQGESIQDVIQAGHSQLSEAGFRPDYLEVRSTSDLSPASSEDSSLVILAAAYMGDTRLIDNLCFTR
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAPA_VIBCH
Sequence: MSFALGQRWISDTESDLGLGTVVALDARTVTLMFAASEENRVYARSDAPVTRVIFNVGDVVDSQQGWSLQVEQVVEDQGVYTYLGTRVDTEESGVALREIFLSNQIRFNKPQDKLFAGQIDRMDNFVLRYRALTNQYQQHKSPMRGLCGMRAGLIPHQLYIAHEVGRRHAPRVLLADEVGLGKTIEAGMIIHQQVLTGRAERILIVVPETLQHQWLVEMMRRFNLHFSIFDEERCVEAFSEADNPFETQQYVLCSLDFLRKSRQRFEQALEAEWDLLVVDEAHHLEWHPEKPSREYQVIEALAEQTPGVLLLTATPEQLGRESHFARLRLLDADRFYDYEAFVKEEEQYAPVADAVTALFSGEKLSDEAKNKITELLSEQDVEPLFKALESHASEDEIALARQELIDNLMDRHGTGRVLFRNTRAAIKGFPVRNVHLLPLEIPSQYTTSMRVAGMLGGKLTPEARAMKMLYPEEIFQEFEGEESSWWQFDSRVNWLLEKVKAKRSEKILVIASRASTALQLEQALREREGIRATVFHEGMSIIERDKAAAYFAQEEGGAQVLICSEIGSEGRNFQFANQLVMFDLPFNPDLLEQRIGRLDRIGQKRDIDVYVPYLTETSQAILARWFQEGLNAFAETCPTGRAVYDAFAERLIPILAAGGGEELEVIIEESAKLNKTLKSQLEVGRDRLLEMHSNGGEKAQQIAEQIAKTDGDTNLVTFALSLFDAIGLHQEDRGENALVVTPAEHMMVPSYPGLPYEGATITFDRDTALSREDMHFISWEHPMVQGGIDLLMSEGVGTCAVSLLKNKALPVGTILLELVYVVDAQAPKRSGISRFLPVSPIRILMDARGNDLSSQVEFESFNRQLSPVNRHLASKLVSSVQHDVHRLITASETAVEPRVSAIREQAQRDMQQSLNSELERLLALKAVNPNIRDEEIEVLDQQIKELTGYIAQAQYQLDSLRLIVVAHN
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: TPX_CHLTE
Sequence: MIMATITLKGNSIHTAGELPAVGSQLPAFTLVKSDLSEVSPADFAGKKLVLNIFPSLDTAVCAASVRRFNKEAGERGDAVVLCISADLPFAQGRFCTTEGLDNVVPLSVYRSPEFGLDYGLTITDGPLKGLLSRAVIVTDASGKVLYAEQVPEIVQEPDYDKALAALA
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides.
What are the official names of this protein?
Thiol peroxidase, Tpx, Peroxiredoxin tpx, Prx, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Tpx subfamily.
Protein: CNO11_DICDI
Sequence: MIDSKDLATLLSLLDESDKPFETIATTFYRTFSKNDHFKVGCAIYTIIKDGFIRIPSQRLIGFYILFSLYKPDSSILSSNSLSSSSILTPSSTTTTTTTEHNNSNNNTSSPSFSSSTVPTNTTLQQNTPSSTSQAISPSSSTSSTSTSSYTNTTTNTTIPSSSPTSTTNTIIENVNDYPIAFNPFLPIFIDELEKQIDSSISSPLFNPIEKQILPLFLTNLPKDFSKKTPKEIINIGMNNTANTTTTTTTTTTTATTNITLPNISISKSSLKEYKNFYLERLPNHCFPSFRSIGISQNILFQLPSTTTTTTNTPTATTTTNTTINTQQSNPSLNTIKNHDINSEELSFFSFEPRFKRAEPPSFNPTTWINPSINHGLLLSNPMSSTVAATIAATATSAPTTILIPSPTTTTSYNSKKIVRDLMTKAIKGRLKKSQILQIKNEMDIDPKLAYYSGLTPKNLPFLVENNTQVAIDTLLKLINSPDFKDHFQTLISMEMNFRSMEVVNALATVDLPPHFIPMYITNCIDSCNNIKDKAMQQRSVRLVCVFIQSLIRNNIINIKNLFCEVQTFCLEFSKIREAISLFKAINDNNNTNNTNTNTNTNNSNTTNTNNNNNNNNNNNNNNNNLINIGEENPNLIIMATK
What is the function of this protein?
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.  Additional complex functions may be a consequence of its influence on mRNA expression (By similarity).
What are the official names of this protein?
CCR4-NOT transcription complex subunit 11.
What is the protein family that this protein belongs to?
Belongs to the CNOT11 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.