PharMolix/UniProtQA huggingface dataset:
Protein: P53_HORSE
Sequence: PAVNNLLLSPDVVNWLDEGPDEAPRMPAAPAPLAPAPATSWPLSSFVPSQKTYPGCYGFRLGFLNSGTAKSVTCTYSPTLNKLFCQLAKTCPVQLLVSSPPPPGTRVRAMAIYKKSEFMTEVVRRCPHHERCSDSSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENFRKKEEPCPEPPPRSTKRVLSSNTSSSPPQKKKPLDGEYFT
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: RS15_STRPN
Sequence: MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNEHIKQHKKDHATYRGLMKKIGRRRNLLAYLRKNDVNRYRELINSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RSMA_BURCH
Sequence: MSNSRQHQGHFARKRFGQNFLVDHGVIDSIVATIGPARGQRMVEIGPGLGALTGPLIERLATPESPLHAVELDRDLIGRLQQRFGALLELHAGDALAFDFRSLAAPGDKPSLRIVGNLPYNISSPLLFHLMTFADAVIDQHFMLQNEVVERMVAEPGTKAFSRLSVMLQYRYVMEKMLDVPPESFQPPPKVDSAIVRMIPYEPHELPDVDPVLLGEIVTAAFSQRRKMLRNTLGDYRETIDFDALGFDLARRAEDVSVAEYVGVAQALAALRKAG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1217_STAHJ
Sequence: MSKIEKITKQLQHEQADAAWITTPLNVFYFTGYRSEPHERLFALLITANGDQTLYCPKMEVEEVKNSPFEGKIIGYLDTENPFEIDPLSFNKLLIESEHLTVKRQRELTQNFGVQHYGDIDQTIKELRNIKNESEIENIREAAKLADKCIEIGTEFLKVGVTEREVVNHIENEIKKFGVSEMSFDTMVLFGDHAASPHGTPGERKLVKDEYVLFDLGVIYNHYCSDMTRTVKFGTPSEEAQTIYNIVLEAETNAIEAIRAGVPLQDIDKIARDIISDAGYGDYFPHRLGHGLGLEEHEYQDVSSTNSNLLEAGMVITIEPGIYVPNVAGVRIEDDILVTENGYEILTHYDK
What are the official names of this protein?
Uncharacterized peptidase SH1217.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: RNC_SHIFL
Sequence: MNPIVINRLQRKLGYTFNHQELLQQALTHRSASSKHNERLEFLGDSILSYVIANALYHRFPRVDEGDMSRMRATLVRGNTLAELAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQTVEKLILNWYQTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPTYLVVQVRGEAHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PB2_I72A2
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMVPERNEQGQTLWSKMSDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKVYKTYFDKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTLIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMVGVLPDMTPSTEMSMRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTERLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKTTKRLTILGKDAGTLIEDPDESTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: HUTH_STRP1
Sequence: MTRVINLDGESLTIEDVIAIARQGVACHIDDSAIEAVNASRKIVDDIVSEKRVVYGVTTGFGSLCNVSISPEDTVQLQENLIRTHASGFGDPLPEDAVRAIMLIRINSLVKGYSGIRLSTIEKLLELLNKGVHPYIPEKGSLGASGDLAPLAHMVLPMLGLGKAYYKGELLSGQEALDKAGIDKISLAAKEGLALINGTTVLTAVGALATYDAIQLLKLSDLAGALSLEVHNGITSPFEENLHTIRPQSGQLATARNIRNLLEGSQNTTVATQSRVQDPYTLRCMPQIHGASKDSIAYVKSKVDIEINSVTDNPIICKDGHVISGGNFHGEPMAQPFDFLGIAISEIGNVSERRVERLVNSQLSKLPSFLVKYPGLNSGFMITQYACASLASENKVLAHPASVDSIPSCENQEDFVSMGTTAARKAFEILKNSRRIVATEIMAACQALDLKPENHELGKGTKVAYDLFRKEVNFIEHDKHIEIYDELNKASAVIEDPSFLEAVEQAVELSIQF
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAC_ACIAD
Sequence: MIMLTTSVAEAAHCLKQGQVLAYPTEAVWGLGCDPFNELAFRQILALKQRPIEKGVILLAGDVGQIEYLLADLDETIRAQVIESWTTRSVDERAITWLLPVSSDQVPTWITGQHHQVAVRVTNHPLCVALCHAFNGFIVSTSANPAGLEPARSLQEASAYFGQGLNYLNGDLGLSQQPSRIIDATTGRVIRD
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_THET8
Sequence: MRGIVTIDGPSASGKSSVARRVAAALGVPYLSSGLLYRAAAFLALRAGVDPGDEEGLLALLEGLGVRLLAQAEGNRVLADGEDLTSFLHTPEVDRVVSAVARLPGVRAWVNRRLKEVPPPFVAEGRDMGTAVFPEAAHKFYLTASPEVRAWRRARERPQAYEEVLRDLLRRDERDKAQSAPAPDALVLDTGGMTLDEVVAWVLAHIRR
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLI4_CANAL
Sequence: MTYFLNDIRPPSPNDITPSFTLLTKELFDKLDGVRKESLGDFRTVTEKKAFIIKTFINTFRTHIGNDIYPSAKLIFPEKSGRIYFIKEVALARLLIKMYKIPKESEDYITLHDWNKSYQRSRRFSIDEKKIRDLPLQASRIISKRRPIVDKLEEYTVPQINSSLDQLALEKVSQGQIDILKPLFDNLSIPEVRWLIHILLNKSILTSMERFFFNTWHPDGYRVFSICNDLQKTLQFSTNPDLRLDPSQLAIHPCFKFKPQLSERLTTSYKTLVKKLQRKHEMDPPYEKKFQELGLENKFYIEEKMDGDRMLLHKDGDSFKFFSRRLKDYSYLYGESFQFGALTKFLAHAFAGNIQSVILDGEMVAYDYERNVILPFGTLKSSAIQESVRQFTTIDQYEQQTAYPFFLVFDILFLNGKDLTNYPLFFRKNILNRILRPIPNRFEVLDTRLGSSSEDIERAIREVVSSRCEGLVLKNVQSKYEIDGFRNPDWIKVKPEYLEKFGENLDLVVIGKSPAIKNSYMCGLKSVTDGVYYSFCTCANGIEIEEFDKIERLTHGKWIKTDVSMPPESLIKFGTKIPTFWIHPSDSLVLEIRARSIDTRAGTSYAVGSTLHNNHCRKIREDKSIDECVTLQEYTHIKANYINDLNKAQTALGKKREPVYSLDNESKLKKVKVESDLFSGIEFLIMSDKREADGEVTTIEEMKAMVKQYGGKIVNSVDLATNYQIMVITERELPVSSQYLSKGIDLVKPIWIYECIKRGCVLQLEPYFIFASKNWDNFNHMVDQYGDSYIIHHPLNIVVPKLSESELEDLRNGFDWGDLKPWIYLFKGLSFYVCGNNLSARFLKERIERFSGDLSKHFIECCYIVIPDNHSRPLMLREIDKMSNQISREMVIDKNGGSSRIPHFVTEAFVQASIKMNYIPDPDDYKFR
What is the function of this protein?
Involved in ds DNA break (DSB) repair.  Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ).  Not required for the repair of DSBs induced by ionizing radiation or UV light.  Has an important role in morphogenesis, positively affecting the capacity to form hyphae.
What are the official names of this protein?
DNA ligase 4, CaLIG4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEUD_RUTMC
Sequence: MQKFTTFTSIAIPLERANIDTDAIIPKQFLKSIKRSGFGVNLFDEWRYLDHGEVGMDNSKRPLNMDFVLNQAKYQGAKILLVRENFGCGSSREHAPWALEDYGFKAIIAPSFADIFYNNCFKNGILPIVQDNNIMDEFFTLSGEIMINLDAQSIHTNSKTYFFEIDIERKRRLINGLDDIGLTLQYTDDIKAFEKDYFNKYNWL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: CHED2_LEPIN
Sequence: MLTKGSKVVNVGIADMQGAQSPEILRTTLGSCIGVVFYAPDKKIGAMAHFMLSKDPSGKDSQKNPFKYAETAIPLLIKKMNEMGCNPGEYSVRLFGGASMFKGVQSSFLQNIGEQNILTARAILEQSKIPLILEDVGGNDGRTISLYLDDGRVLLKKGGFEKYLYKVR
What is the function of this protein?
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
What are the official names of this protein?
Probable chemoreceptor glutamine deamidase CheD 2.
What is the protein family that this protein belongs to?
Belongs to the CheD family.
Protein: CMPB_SYNY3
Sequence: MTTTISQRKNRAAGANPLQKFWRKRRGDILPPIFGILGFLLLWQLISSAGLIKLPPPSSLWTDPRTRTLLMYPFYDQGGLDKGLFWQTLASLGRVAQGYSLAAIVGISTGILVGTQPLLDKALDPIFQFLRMVAPLAWVPIALVALQQNQPAAIFVIFITSVWPILINTTEGVKQIPQDYINVRKVLRLSPQKFFFKILIPSALPYIFTGLRIAIGLAWLAIIAAEIVMSGIVGIGFFIWDAYQQNYISEIILAVFYIGAVGLLLDRGIAYLQKLIAPGQ
What is the function of this protein?
Part of the ABC transporter complex CmpABCD involved in bicarbonate transport.  Probably responsible for the translocation of the substrate across the membrane (By similarity).
What are the official names of this protein?
Bicarbonate transport system permease protein CmpB.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL14_ALTMD
Sequence: MIQMQTNLDVADNSGARRVQCIKVLGGSHRRYAGIGDIIKVTVKEAIPRGKVKKGDVLNAVVVRTRKGVRRADGSTIRFDGNAAVMLNANKQPIGTRIFGPVTRELRSENFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: PPAC_BREBN
Sequence: MEKKLIFGHKNPDTDSICSALVYADLKTKLGANVEPVRLGVISSETAFVLNYFQVKEPRLVETVANEVNEVILVDHNERQQSANDIEQVQVVEVIDHHRIANFETSNPLYFRAEPVGCTTTILKKMYKENGVDIPKEMAGLMLSAIISDTLLLKSPTCTEQDVAAAHELAEIAGVNLEAYGLDMLKAGADLSDKTIEQLLTLDAKEFQMGNAKVEIAQVNAVDVNDVLARQGELEAAMNASIAEKALDLFVFVVTDILNNDSVAIALGSATQAVEKAYQVTLVDNKAVLKGVVSRKKQIVPVLTDTFQAL
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_MYCSK
Sequence: MARYTGPATRKSRRLGVDLVGGDQSFEKRPYPPGQHGRARIKESEYRTQLQEKQKARFTYGVLEKQFRRYYDEANRQPGKTGDNLLRILESRLDNVVYRAGLARTRRMARQLVSHGHFTVNGVKVDIPSYRVSQYDIIDVREKSLNTDPFVIARETAGDRPIPSWLQVVGERQRILVHQLPERAQIDVPLTEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: HBOH_CUPMC
Sequence: MQQRHLSQSAHSHGHGTRRAHRRNTIAIAVATLAVAACGGFGTNGSGGNTGPNVKPAFISGPVGVKSYDGNTDDLLTAGLGKDGLAAAAPAFANPNAPTAVELRRNAIWANYRAIVDVQAAGGYGSLYGPNVDAKGNVTTGQGKVPGTEYIAFTDDGSGRQNVTVMAQVPDGFDVKHPCIISATSSGSRGVYGGIAVGEWGLKHNCAVAYTDKGTGAAPHDLGSDTVPLIDGTRQTRAGAGTQAQFAAQPGASETLAGFNSSTPHRLAFKHAHSQQNPEANWGANTLQAIQFTLWAVNDKFGRTNTDGMRQATFTPANVLVIASAISNGGGAAIAAAEQDTGGLIDGVAVGEPNVNLPPTAGVVVKRGGVPVAASGKHLYDYTTIANLYQLCASQDASLGNAPFAKTAGQAALNRCASLAAKKMIAGGSTSAQATSALDALHRAGWEPESDDLFASLSALEVGSSISVTYANAYARASVTDRLCHYSFSSPGSPPQANPVTAPAAALAGLFSTGNGIPPTTAVTLMNDANPSGAMRDFTSISPSTKLADGNVDGALCLRGLLDTRNPALMTGIGQTYRTGNLGGRPSVIVQGRSDGLLPVNHTSRPYLGLNKHVEGASSRLSYIEVTNGQHFDGFIDVIPGYAKRYIPMHVYVNRALDAVYANLRDGTPLPPSQVVRTTPRGGADTDTVGPRIQPSNVPPIAATPAAGDAITVTGSTVDVPN
What is the function of this protein?
Participates in the degradation of poly-3-hydroxybutyrate (PHB).  It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.
What are the official names of this protein?
D-(-)-3-hydroxybutyrate oligomer hydrolase, 3HB-oligomer hydrolase, 3HBOH.
What is the protein family that this protein belongs to?
Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.
What are the subcellular locations of this protein?
Secreted.
Protein: GSA_NEIG1
Sequence: MNRNEILFDRAKAIIPGGVNSPVRAFGSVGGVPRFIKKAEGAYVWDENGTRYTDYVGSWGPAIVGHAHPEVVEAVREAALGGLSFGAPTEGEIAIAEQIAEIMPSVERLRLVSSGTEATMTAIRLARGFTGRDKIIKFEGCYHGHSDSLLVKAGSGLLTFGNPSSAGVPADFTKHTLVLEYNNIAQLEEAFAQSGDEIACVIVEPFVGNMNLVRPTEAFVKALRGLTEKHGAVLIYDEVMTGFRVALGGAQSLHGITPDLTTMGKVIGGGMPLAAFGGRKDIMECISPLGGVYQAGTLSGNPIAVAAGLKTLEIIQREGFYENLTALTQRLANGIAAAKAHGIEFAADSVGGMFGLYFAAHVPRNYADMARSNIDAFKRFFHGMLDRGIAFGPSAYEAGFVSAAHTPELIDETVAVAVEVFKAMAA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUC_STAAS
Sequence: MGQTLFDKVWNRHVLYGKLGEPQLLYIDLHLIHEVTSPQAFEGLRLQNRKLRRPDLTFATLDHNVPTIDIFNIKDEIANKQITTLQKNAIDFGVHIFDMGSDEQGIVHMVGPETGLTQPGKTIVCGDSHTATHGAFGAIAFGIGTSEVEHVFATQTLWQTKPKNLKIDINGTLPTGVYAKDIILHLIKTYGVDFGTGYALEFTGETIKNLSMDGRMTICNMAIEGGAKYGIIQPDDITFEYVKGRPFADNFVKSVDKWRELYSDDDAIFDRVIELDVSTLEPQVTWGTNPEMGVNFSEPFPEISDINDQRAYDYMGLEPGQKAEDIDLGYVFLGSCTNARLSDLIEASHIVKGNKVHPNITAIVVPGSRTVKKEAEKLGLDTIFKNAGFEWREPGCSMCLGMNPDQVPEGVHCASTSNRNFEGRQGKGARTHLVSPAMAAAAAIHGKFVDVRKVVV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: NU4LM_CHLAE
Sequence: MSPIFINITLAFTISLLGMLVYRSHLMASLLCLEGMMMSLFITIALMASNTHSPLINIMPITLLVFAACETAVGLALLVSISNTYGLDYIHNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TNIP2_MOUSE
Sequence: MSSGDPRSGRQDGAPRAAAALCGLYHEAGQQLQRLKDQLAARDALIASLRTRLAALEGHTAPSLVDALLDQVERFREQLRRQEEGASETQLRQEVERLTERLEEKEREMQQLMSQPQHEQEKEVVLLRRSVAEKEKARAASDVLCRSLADETHQLRRTLAATAHMCQHLAKCLDERQCAQGDAGEKSPAELEQTSSDASGQSVIKKLQEENRLLKQKVTHVEDLNAKWQRYDASRDEYVKGLHAQLKRRQVPLEPELMKKEISRLNRQLEEKISDCAEANQELTAMRMSRDTALERVQMLEQQILAYKDDFKSERADRERAHSRIQELEEKIMSLMYQVSQRQDSREPGPCRIHTGNKTAKYLEMDALEHVTPGGWRPESRSQQMEPSAEGGHVCTAQRGQGDLQCPHCLRCFSDEQGEAFLRHLSECCQ
What is the function of this protein?
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG.  Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation.  Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific.  Required for stability of MAP3K8.  Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival.  May act as transcriptional coactivator when translocated to the nucleus.  Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
What are the official names of this protein?
TNFAIP3-interacting protein 2, A20-binding inhibitor of NF-kappa-B activation 2, ABIN-2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SBT26_ARATH
Sequence: MDIGCKVLVFFTCFLTVTAEIYIVTMEGEPIISYKGGDNGFEATAVESDEKIDTTSELVTSYARHLERKHDMLLGMLFVEGSYKKLYSYKHLINGFAAHVSPDQAEMLRRAPGVKSVDRDWKVRKLTTHTPQFLGLPTDVWPTGGGYDRAGEDIVIGFIDSGIFPHHPSFASHHTTVPYGPHPSYKGKCEEDPHTKISFCNGKIIGAQHFAEAAKAAGAFNPDIDFASPMDGDGHGSHTAAIAAGNNGIPVRMHGYEFGKASGMAPRARIAVYKALYRLFGGFVADVVAAIDQAVHDGVDILSLSVGPNSPPATTKTTFLNPFDATLLGAVKAGVFVAQAAGNGGPFPKTLVSYSPWITTVAAAIDDRRYKNHLTLGNGKMLAGIGLSPSTRPHRSYKMVSANDVLLGSSGMKYNPSDCQKPEVLNKKLVEGNILLCGYSFNFVAGSASIKKVAETAKHLGAAGFVLVVENVSPGTKFDPVPSCIPGILITDVSKSMDLIDYYNVTTSRDWMGRVKDFKAEGSIGDGLEPILHKSAPEVALFSARGPNTKDFSFQDADLLKPDILAPGSLIWSAWSANGTDEANYIGEGFALISGTSMAAPHIAGIAALVKQKHPQWSPAAIKSALMTTSTVIDRAGRPLQAQQYSETETVTLVKATPFDYGSGHVNPSAALDPGLIFDAGYEDYIGFLCTTPGIDAHEIKNFTNTPCNFKMVHPSNFNTPSIAISHLVRTQTVTRRVTNVAEEEETYTITSRMEPAIAIEVSPPAMTVRAGASRTFSVTLTVRSVTGAYSFGQVTLKGSRGHKVTLPVVAMGQRR
What are the official names of this protein?
Subtilisin-like protease SBT2.6, Subtilase subfamily 2 member 6, AtSBT2.6.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y7359_AFIC5
Sequence: MSAPRPVYDPSWDRANPNEVRRSIRERGYTGYTAGLAPGFVQANICILPKDWAEDFLLFCQRNPKPCPLLTRSDVGDPSLPALSDNIDIRTDVPRYQIFRNGEFTEEVTDIRSHWRDDLVTFAFGCSFSFEEALQDDGIPLRFLANNNVAGVYVSTMPTEAAGPFEAPLIVTMRSFTPQNAIRAIQITSRFPNVHGAPVHIGDPAQIGVDLAKRYQNVGDPTVGEGEIPVFWACGLTPQFAVMKAKPPFCITHAPSSMLVTDLRNSSLAVM
What are the official names of this protein?
Putative hydro-lyase OCAR_7359/OCA5_c07590.
What is the protein family that this protein belongs to?
Belongs to the D-glutamate cyclase family.
Protein: PSA6_CAEEL
Sequence: MSRGSSAGFDRHITIFSPEGRVYQVEYAFKAINSTNLTAVAVKGADAAVIAVQKRVPDSLIVADTVTSVYQISQSVGCCAIGMIPDAKFQIKRAQGEAASWKYKNGYDMPCELLAKKMADLNQYYTQNAEMRSLGCALLFISYDDEKGPEVYRVDPAGYYRGMKGVSVGVKQLPATSFLEKKIKKKSELTSTEAIELAIEALQTSLGIDVRSKDLEVVVVTKDNSKFTKLTSDQVEHHLNQIANRD
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity (By similarity).
What are the official names of this protein?
Proteasome subunit alpha type-6, Proteasome subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ARPC3_MOUSE
Sequence: MPAYHSSLMDPDTKLIGNMALLPLRSQFKGPAPRETKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPASKQEDEMMRAYLQQLRQETGLRLCEKVFDPQSDKPSKWWTCFVKRQFMNKSLSGPGQ
What is the function of this protein?
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility.  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 3, Arp2/3 complex 21 kDa subunit, p21-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC3 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein: YOPB_YERPS
Sequence: MSALITHDRSTPVTGSLLPYVETPAPAPLQTQQVAGELKDKNGGVSSQGVQLPAPLAVVASQVTEGQQQEVTKLLESVTRGAAGSQLISNYVSVLTKFTLASPDTFEIELGKLVSNLEEVRKDIKIADIQRLHEQNMKKIEENQEKIKETEENAKQVKKSGIASKIFGWLSAIASVIVGAIMVASGVGAVAGAMMVASGVIGMANMAVKQAAEDGLISQEAMKILGPILTAIEVALTVVSTVMTFGGSALKCLANIGAKLGANTASLAAKGAEFSAKVAQISTGISNTVGSAVTKLGGSFAGLTMSHAIRTGSQATQVAVGVGSGITQTINNKKQADLQHNNADLALNKADMAALQSIIDRLKEELSHLSESHQQVMELIFQMINAKGDMLHNLAGRPHTV
What is the function of this protein?
Plays a role in virulence.
What are the official names of this protein?
Protein YopB.
What is the protein family that this protein belongs to?
To Shigella invasion plasmid IpaB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.