PharMolix/UniProtQA huggingface dataset:
Protein: ZO71_XENLA
Sequence: MGMWEEASDTGMKGKKKDKNEEEEERGKKERMVNLTLEMIYLLTGEHYIPRKKSDDGGALHAPGSVIQKENNKNDKKILELMSNIIQLLTGEVAIRTHHVSIYFSLDEWDYIKGNKELYEEGIKEEPQQLRPQACEYKDESNVTAHMEATLCCNSDGNFINPENPEISPGEQPPPANGIKEEATSSEEGNQSDCSINPLTEEIQGTDTPTPIMGCSLNYSLSDNYISDEIKEEETSCQGRNQSDCSITPLTEQIQGTDTPTPIMGCSLKDNKYDGNPHWSPKNTLRRKYSCNECHEYLIHKRDFGKHQMTHKREKSFSCSECGKCFLNQLCPDRHQTGKKPFSCSKCGKCFAFLSDLTVHRRIHTGERPFSCSECGKGFTRPNALIIHHRTHTGEKPFSCSECGKCFSKQSSLVHHQRTHIGEKPFCCSECDKCFASSSELNIHQRTHTGEKPFSCSECGKCFTNHSHFAHHQMIHTGEKPFCCSKCGKCFASSSDLTFHRRTHTREKTFSCSECGKCFSNHSHLARHQMIHTGEKPFCCSECGKCFSSSSGLTAHQQRTHMKVKPFSCSACGKCFSNRSHLIRHQMIHTGEKPFSCFECRKCFSNPSNLARHQMTHTGEKPFSCSECGKCFASSSDLTFHHRTHTGEKPFSCSECGKCYSKKSSLVHHQRTHTGEKPFSCSKCDKCFASSSELNIHQRTHTGEKAFSCSECGKCFTNRSQLSRHQMIHTGEKPISCPECEECFVSSSQLTAHQQQAHRMVKPFSCLECGKCFSNRSNFARHQMIHTGEKPFSCSECRKGFSNQSSLARHQMTHTGEKPFSCSECGKRFSNQSHLARHQMIHTGEKPFSCSECAKGFSNQSGLARHQMTHTGEKPFACSECGKCFASSSKLTAHQRTH
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Oocyte zinc finger protein XlCOF7.1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SURE_RHIE6
Sequence: MRILLTNDDGIHAEGLAALERIARTLSDDVWIVAPETDQSGLAHSLSLSEPLRLRKISDKHFALRGTPTDCVIMGIRQVMDIKPDLVLSGVNSGSNVADDVTYSGTIAGAIEGTMQGVRSFALSQAYLYEDGARIVPWEVCETHAPALLEKLMDLDLPEGTFLNLNFPNCRPGEVDGAEVTMQGKLAFNLQVDARSDGRGFPYYWLKFGERAGAFIEGTDIHALKHNKISVTPLKLDLTDYSVTDRVARALGYGAQV
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAD_BORT9
Sequence: MRVALFPGSFDPITWGHIDLVKRASLIFDKVIVLVANNSAKSYLLSDIERYELTFEVIASLGWSRIFVDRYDGIILDYALKNNIGFIVRGVRAFHDFEFEFERYVVNNKLSPSIDIVFLPSSDKYLFVRSDLVKELIKNKNFDLSSFIPDLVQKKLKSKFIDKLS
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGI_SHISS
Sequence: MIKFLSALILLLVTTAAQAERIRDLTSVQGVRQNSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTESLPPFGRQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAVIERELPSQFGVGNTLNLQLNDEDFSMAQQIADTINRVRGYGSATALDARTIQVRVPSGNSSQVRFLADIQNMQVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQANVSQPDTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSASLNNVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: ALG1_CANAL
Sequence: MGEIIKYKGFDHVWQYSGPWLYCLIGIYISLPVLAYHILPWIFHKNRSNKRKTISIFVLGDLGHSPRMCYHASSFSKLDYYVNLCGYVETEPSHQIVDDVNIDIIPIEAIKNTNNLPYIMFAILKVVRQCGKIWSILWDTRGSDYIMIQNPPSIPILLIVILFKTVFSRETKLIIDWHNLNYTILNLRYNNLNHPFVKLVKLYEKILGQFANLNITVTKSMKKYLVKEFGFQKSKIVTLYDRPGVQFQPLSNKREFMSEHKLFEDIDIEKYKVLISSTSFTPDEDFNILLDALKNYENTPNTPPILLIVTGKGPLKGKFLETVDKLEFTNKVCVKSAWLSSEDYPKVLACADLGISLHTSSSGIDLPMKIVDFFGCGVPVVSLDFPAIDELVKNKVNGLITNSKSDQTKEVARLVTEVFTDDALLRSIKEGALEESNSRWDENWMQTFSSIFENKS
What is the function of this protein?
Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation.  Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity).
What are the official names of this protein?
Chitobiosyldiphosphodolichol beta-mannosyltransferase, Asparagine-linked glycosylation protein 1, Beta-1,4-mannosyltransferase, GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase, GDP-mannose-dolichol diphosphochitobiose mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: Y5849_ARATH
Sequence: MSSIMYHDNHLTDSGKNMSSGLSLLAYVTVMVAEEEEQRSRLLAEKREESKCKMSFFYLFPRKIKSSLAKRRYTQQNPNGASTCSSSLPDLNLIPTDFETDNLQNPCFDEPMVCDEEQRLKKGKSKIVYDEDYDDESEKKLFDNLNGASTSSSSLLNLPCLEPSTETKDVPNPNYQSSSPSSCLTGKTNRKRRAVEQRKSGKVKKVKVSPLPRLCTEMPEWIFQVMRYMNADAETPRLIFERTLFKSDVNSNLSRLLMPFQKLIRNDFLTPAECRAMQKDEDNDEEDDENIGVGTVLVNQRFQKWGLRFKIWAMEKDSGHGTLNYTLNWGWNDVVKSSSLKVGDKISLWTFRCRGVLCFALDTE
What are the official names of this protein?
B3 domain-containing protein At5g38490.
What are the subcellular locations of this protein?
Nucleus.
Protein: NEPI_ECOL5
Sequence: MSEFIAENRGANAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGVALGGFWAISASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKKS
What is the function of this protein?
Involved in the efflux of purine ribonucleosides, such as inosine and guanosine.
What are the official names of this protein?
Purine ribonucleoside efflux pump NepI.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPA_NEUCR
Sequence: MFRNALRQSTRAVGAFSATGRVAARNAAPVVSAVQARTYADAKATPTEVSSILEQRIRGVQEESNLAETGRVLSVGDGIARVHGMANVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGETVKRTGEIVDVPVGPELLGRVIDALGNPIDGKGPINCKEKRRAQLKAPGILPRQSVNQPVQTGLKSVDAMVPIGRGQRELIIGDRQTGKTAVALDAILNQKRWNSGSDEDKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYLAPFTGACVGEYFRDNGKHSLVIFDDLTKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNKTHGGGSMTALPVIETQGGDVSAYIPTNVISITDGQIFLESELFYKGVRPAINVGLSVSRVGSAAQLKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDAATKQTLNRGERLTELLKQKQYSPMAVNEMVPLIFAGVNGFLDSVPVAKILQWEADFLAHLKTNEPEIMATIDKEGAISKDLEAKLRDVIQTFTKSFLG
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.  Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
What are the official names of this protein?
ATP synthase subunit alpha, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Protein: Y1978_AQUAE
Sequence: MILFSPKEIKDIEELVKEREGSVEEIEVIKLNETPNISQFLVFIKTSEVPHYHAEHDLTFTVLKGKGELYLEGEKKKLKEGDWAFIPKGAVHFYRNTSELSVLLAIFSPSYDGKDSVRVEL
What are the official names of this protein?
Uncharacterized protein aq_1978.
Protein: EX7S_PSEPF
Sequence: MARKKAALDFEQSLADLQTLVERLENGELSLEDSLTAFEQGIGLTRDCQAALAQAEQKVQVLLERDGELAEEPFDADQPE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BETB_BRUA2
Sequence: MKAQPKASHFIGGAFVEDKAGKPLPVIYPATGEEIASLYSATPGIIEAAYAAALKAQGEWAALKPVERGRILRRTAEILREKNRKLSKLETLDTGKALQETLVADAASAADALEFFGGIISGFNGEFVELGGSFAYTRREALGICVGIGAWNYPIQIAAWKSAPALAMGNAFIFKPSENTPLSALALAEAYKEAGLPDGLFNVVQGYGDVGAALVNHRLTAKVSLTGSVPTGRRIMAQAGEQLKHVTMELGGKSPLIVFDDADLESAIGGAMLGNFYSTGQVCSNGTRVFVHKNIRERFIERLVERTRKIRIGDPFDEATQMGPLISAAQRDKVLSYIKKGKAEGATLACGGGVPKLQGFDKGFFIEPTVFADVTDTMTIAREEIFGPVMSVLEFSDEDEVIARANDSEFGLAAGVFTADLSRGHHVIGQIKAGTCWINAYNLTPVEVPFGGYKQSGIGRENGIAALAHYSQIKTVYVEMGKVDSPY
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: CSN4_PIG
Sequence: MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity).  Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity).  The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity).  CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 4, SGN4, Signalosome subunit 4.
What is the protein family that this protein belongs to?
Belongs to the CSN4 family.
Protein: ATPD_BRUMB
Sequence: MAETSSLISGVAQRCAGSLFELALDANSVASVEKDLGRFEALLSGSEDLRRLISSPVFSSEDQLHAIGAIADKAGIKGLVGNFLRVVAQNRRLFALPGIIAAFRQIAAEHRGEISADVVSAHELTSAQQNELKATLKGVAGKDVTINVTVDPSILGGLIVKMGSRQIDTSLRTKLSSLKLALKEVG
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LIND_SPHIU
Sequence: MSADTETLARKVREEVIKPEQSTLISPDRQSPSLLRREATVEPRFELFHFVFSVCSQKVRGTLMEKGVTFGSNELTILPPQNENYCPQYVRLRLRSEAAAKHRPVSSFTGQSSVDSEGFDPLVVPTLVDHETGRILADSKAICLYLCDALSGGTDLLPADIREAVLKQVQLADTTPHVALLYGADPDGDRRPESMQAVMPGIHAHKIDAVRRNIPLADGDPLLLEAYQHKIVKEEAAASFVINEPQMRTAISKAEQLVTDLDRDLGASTGPWLFGDRFTLADLFWAVSLYRFLWLGYSGFWKDGAGKPRVEAYANRLFARPSVKDAIIQWPGHPPSENVIHLLSNA
What is the function of this protein?
Catalyzes the degradation of 2,5-dichlorohydroquinone (2,5-DCHQ) into hydroquinone (HQ) via chlorohydroquinone (CHQ).  Is involved in the degradation pathway that allows S. japonicum UT26 to grow on gamma-hexachlorocyclohexane (gamma-HCH or lindane) as the sole source of carbon and energy.  However, the conversion of CHQ to HQ by LinD seems not to be essential for this degradation pathway, because the conversion rate of CHQ to HQ is much lower than that of 2,5-DCHQ to CHQ.  CHQ is more efficiently degraded by LinE in strain UT26.
What are the official names of this protein?
2,5-dichlorohydroquinone reductive dechlorinase, 2,5-DCHQ dechlorinase, Glutathione-dependent reductive dehalogenase.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily.
Protein: PFA4_YEAST
Sequence: MPVKLRWPWLGIAIPTFLISFIGYGAHYFILSNFLSVPKQITFEFCLSMIWLSYYLAICTNPGRPLPNYKPPPDIWRNFCKKCQSYKPERSHHCKTCNQCVLMMDHHCPWTMNCVGFANYPHFLRFLFWIIVTTSVLFCIQAKRIYFIWQQRHLPGYFFKKSELIFLTISSPLNSFVLLTITILFLRCLFNQILNGRSQIESWDMDRLESLFNSGRLTQKLIDNTWRIYPESRSFQNKKDAEEHLTKKRPRFDELVNFPYDFDLYTNALLYLGPIHLWLWPYGVPTGDGNNFPKNGISKYEANSSLEDHILSLPWPPDGGKTNTVFNHGSSTIEMRNESGEQLIRTRLPQNGRHASREKWYNDWGESLDDFGVDVDME
What is the function of this protein?
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.  Palmitoylates several amino acid permeases (PubMed:16751107).  Palmitoylates chitin synthase CHS3, which is required for its proper export from the ER (PubMed:16818716, PubMed:28346351).  Can palmitoylate RAS2 in vitro (PubMed:12379641).
What are the official names of this protein?
Palmitoyltransferase PFA4, Protein S-acyltransferase, PAT, Protein fatty acyltransferase 4.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi- pass membrane protein.
Protein: CTU2_XENTR
Sequence: MCEEEEVYCPELQDTTQGKSLGKTCMKCKESSAVLLIRAGDAFCKSCFKEYFVHKFRATLGKNRVIYPGEKVLLAFSGGPSSSAMVQQVQEGMSRDAPKKLRFVPGILFIDEGTTCGMSHEERQQNMSEVQNVLQQTGFPFYIVSLEQVFSLPGSILQRGVPEQRANYKQEVDRFMVQQQAQGETGCSDILENLAKLGVNVSESSRESDKMFQSTCRHPPDTHTQKLIQLFASAKTLTAKHQLLHTLRSHLILHIARTCGYSKVMSGESCTRLSVSLLSNISLGRGAFLPLDTGFCDSRYGDVDIIRPMREYSLKEIAFYNRLFHVSSVFIPALNTKVLENSSIQQLSEVFINRLQADFPSTVSTVYRTSEKLNVSKIDANQGTCAKERCLLCLSPLDTQVGEASAFHATQISHYISQKILMKFNDPANSSGKSCCQEGKCCKGPGYGDFCQPRALQAPSFVDMLCYGCRLTVKDLQSLDALPQYVLHEAEHRSRRIEMRKEIEEFLLDKDEENLH
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  May act by forming a heterodimer with ctu1/atpbd3 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position.
What are the official names of this protein?
Cytoplasmic tRNA 2-thiolation protein 2.
What is the protein family that this protein belongs to?
Belongs to the CTU2/NCS2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNA2_RAT
Sequence: MEPLDDLDLLLLEEDSGAEAVPRMEILQKKADAFFAETVLSRGVDNRYLVLAVETKLNERGAEEKHLLITVSQEGEQEVLCILRNGWSSVPVEPGDIIHIEGDCTSEPWIVDDDFGYFILSPDMLISGTSVASSIRCLRRAVLSETFRVSDTATRQMLIGTILHEVFQKAISESFAPEKLQELALQTLREVRHLKEMYRLNLSQDEVRCEVEEYLPSFSKWADEFMHKGTKAEFPQMHLSLPSDSSDRSSPCNIEVVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKTKYKIMPLELKTGKESNSIEHRGQVILYTLLSQERREDPEAGWLLYLKTGQMYPVPANHLDKRELLKLRNQLAFSLLHRVSRAAAGEEARLLALPQIIEEEKTCKYCSQMGNCALYSRAVEQVHDTSIPEGMRSKIQEGTQHLTRAHLKYFSLWCLMLTLESQSKDTKKSHQSIWLTPASKLEESGNCIGSLVRTEPVKRVCDGHYLHNFQRKNGPMPATNLMAGDRIILSGEERKLFALSKGYVKRIDTAAVTCLLDRNLSTLPETTLFRLDREEKHGDINTPLGNLSKLMENTDSSKRLRELIIDFKEPQFIAYLSSVLPHDAKDTVANILKGLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICALVRILSACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQSHKVHPDIQKFTEEEMCRLRSIASLAHLEELYNSHPVVATTCMGISHPMFSRKTFDFCIVDEASQISQPICLGPLFFSRRFVLVGDHKQLPPLVLNREARALGMSESLFKRLERNESAVVQLTIQYRMNRKIMSLSNKLTYEGKLECGSDRVANAVITLPNLKDVRLEFYADYSDNPWLAGVFEPDNPVCFLNTDKVPAPEQIENGGVSNVTEARLIVFLTSTFIKAGCSPSDIGIIAPYRQQLRTITDLLARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNEDGTLGELLKDWRRLNVAITRAKHKLILLGSVSSLKRFPPLEKLFDHLNAEQLISNLPSREHESLYHILGDCQRD
What is the function of this protein?
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion.  Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1.  Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA.  Also involved in DNA replication checkpoint independently of Okazaki fragments processing.  Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities.  While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate.  According to various reports, the helicase activity is weak and its function remains largely unclear.  Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity).
What are the official names of this protein?
DNA replication ATP-dependent helicase/nuclease DNA2, DNA replication ATP-dependent helicase-like homolog.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: KDGD_RHIME
Sequence: MSPEEIKSRVGSGLLSFPVTHFTSDYKLNLESYRRHVEWLSGFEAAALFAAGGTGEFFSLSPNEVGQVTRAAKDVSGEVPIIAGCGYGTSLAVETAKIVEEAGADGILLLPHYLTEAPQEGIYAHVKAVCDSTGLGVILYNRANSVANADTVARLAEACPNLIGFKDGTGKVDLVRHVTAKLGDRLCYIGGMPTHELFAEGFNGVGVTTYSSAVFNFVPELAQRFYRAMRAGDRAVMEGILHTFFFPFAALRDRKAGYPVSIIKAGVELAGFAPGPVRPPLVDLTGEEREILQGLIEASRR
What are the official names of this protein?
Probable 5-dehydro-4-deoxyglucarate dehydratase, 5-keto-4-deoxy-glucarate dehydratase, KDGDH.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: PHBS_MYCBO
Sequence: MTECFLSDQEIRKLNRDLRILIAANGTLTRVLNIVADDEVIVQIVKQRIHDVSPKLSEFEQLGQVGVGRVLQRYIILKGRNSEHLFVAAESLIAIDRLPAAIITRLTQTNDPLGEVMAASHIETFKEEAKVWVGDLPGWLALHGYQNSRKRAVARRYRVISGGQPIMVVTEHFLRSVFRDAPHEEPDRWQFSNAITLAR
What is the function of this protein?
Removes the pyruvyl group from chorismate to provide 4-hydroxybenzoate (4HB).  Involved in the synthesis of glycosylated p-hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity).
What are the official names of this protein?
Chorismate pyruvate-lyase, 4-HB synthase, p-hydroxybenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the chorismate pyruvate-lyase type 2 family.
Protein: RS12_SYNJA
Sequence: MPTIQQLIREERKAAVRKTKAPALKGCPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGFEVTAYIPGIGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGTLDAAGVKDRKQGRSKYGAKRPKPGQAPAAAGKKK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PPGB_BOVIN
Sequence: MFRAALWPPVLLLLQLLLLACAPGGEGAHDQDEIRFLPGLAKQPSFRQYSGYLKGSGSKRLHYWFVESQKDPKSSPVVLWLNGGPGCSSLDGLLTEHGPFLIQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKSYATNDTEVAQSNFEALKDFFCLFPEYKGNELFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNQCNFHDNKEPECVANLQEVSHIVASSGLNIYNLYAPCAGGVPSHVRHEKDTVVVQDLGNIFTRLPLKRVWHQTLLRSGEKVHLDPPCTNTTAASNYLNDPHVRKALHIPEQLPRWDLCNFLVNIQYRRLYQSMCSQYLKLLSAQKYRILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVDYGESGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPQAALTMFSRFLNRQPY
What is the function of this protein?
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity.  This protein is also a carboxypeptidase and can deamidate tachykinins (By similarity).
What are the official names of this protein?
Lysosomal protective protein, Cathepsin A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: RL16_CITK8
Sequence: MLQPKRTKFRKMHKGRNRGLAQGTDVSFGSFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: ARGA_BUCAP
Sequence: MRERTTELVQGFRHSVPYINAHRGKKFVIMLSGEAIKYGNFSGIINDIGLLHSLGIRLIVVYGSCPQINANLKEKNIKITYHKYIRVTDLLSLEQVKQAAGRLQLDITARLSMSLSNTPLQGANINVVSGNFIIAQPLGVDDGIDYCHSGRIRRIDKKAINCQLENGAIVLIGPVAVSVTGESFNLTSEEIATQVSIKLKAEKMIGFCSKQGVIDSQGKTISELLPNNIQNEIKKLEGKGDYISSTIRFLRGSIKACKSGVNRSHLISYHKNGALLQELFSRDGIGTQMVMESAEKIRQANINDIGGILELIRPLEKKGILVRRSREQLEMEVDKFTIIERDNLTIACAALYPFFKEKIGEMACVAVHPDYRNSSRGDLLLQTMKLNAKKLNLKKIFVLTTQSIHWFQERGFILVDVEILPESKKKMYNYQRCSKILMIDLF
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_DEIDV
Sequence: MRAVLQRVTRATCTVEGTITGQTGPGLLILLGVAPTDTPEVACALAGKTAKLRIFNDEAGKMNRSVLDIGGGVLSISQFTLYADTRSGNRPSFIAAAPPDRARELYGAFNEALRAQGLEVSEGVFGAHMVLDLTNDGPVTITLDVP
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.