PharMolix/UniProtQA huggingface dataset:
Protein: TGT_YERPG
Sequence: MKYELQKTDGRARRGRLVFERGVVETPAFMPVGTYGTVKGMTPEEVKETGAQILLGNTFHLWLRPGQEIMKLHGDLHDFMQWHGPILTDSGGFQVFSLGAMRKIKEEGVHFKNPINGDSVFLSPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAARSRQRFDELNNKNALFGIIQGGVYEDLRDVSVKGLVDIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPEDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKDDTATLDEHCDCYTCRHYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRQAIEEGKLEHFVEDFYGRIGKPVPPLNV
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: CH601_ACIC1
Sequence: MAKMIAFDEAARRALERGMNQLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQTLVREGLRNVAAGANPMALKRGIEAATERVCQALLEIAKDVETREQIASTASISAGDTAVGEMIAEAMDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDSERMEAVLEDPYILIANQKISAVKDLLPVLEKVMQAGKPLAIIAEDVEGEALATLVVNKIRGTFRSVAVKAPGFGDRRKAMLGDIAVLTGGQVISEEVGLKLENVGLDLLGRARKVVVTKDETTIVEGAGDPEQIAGRVNQIRAEIEKTDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQAGKTAFEKLDLEGDEATGARIVELALEAPLKQIAINAGLEGGVVVEKVRSLEPGWGLNAQTGEYVDMIKAGIIDPAKVTRSALQNAASIAGLFLTTEAVVAEKPEKEKTPAAPGGGDMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_HUPLU
Sequence: MTLNLRVMTPNRTVWNSEVQEMILSTNSGQIGVLPNHAPLLTALDIGITKIRLNGQWSTMALMGGFAMVDNNQVTILVNEAEEAAGIDPQEAKETFRIAQTNLARAEGKKQVIEANLAFKRAKARLEAIDATLSYASN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: COMB_SYNY3
Sequence: MEIFVYHTPELTPDQSLPDCAVVIDVLRATTTIATALKVGAEAVQVFSSLDDLMATSESWPGEKRLRAGERGGAAVAGYDLGNSPLDCTSELMAGKRLFLSTTNGTRALQRVKDCPQLVTASLVNRGAAVDYLAQTQPKTVWLLGSGWEGGYSLEDTVCAGAIASLLREKGIDFTVGNDEVVAAQSLYRQWRSDLLNLFKQASHGQRLLKLDRLEDLRYCATEDLIDILPKQVSPGVLTAA
What are the official names of this protein?
Probable 2-phosphosulfolactate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the ComB family.
Protein: QUEF_BURM9
Sequence: MNPEHSPLGKATVYANQYDASLLFPIPRAGAREQIGIGAPLPFFGTDIWNAYELSWLNARGKPQIAIATFYVPAESPNIVESKSFKLYLGSFAQTAFESADAVRDALKRDVSAACGASVTVRLATPAEFRKLQMDELDGLSLDRLDLDAHVYETDPSFLTASHDEAPVEETLVTDLLKSNCPVTGQPDWGSVQIHYVGAPIDHAGLLRYIISFRNHTGFHEQCVERIFVDILRACQPVKLAVYARYTRRGGLDINPFRTNYNQPMPDNARTARQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_MARN8
Sequence: MSKRTLRIATRSSALALWQAEFIKAELERLHDNVDVELIKIKTQGDKILDVPLAKIGGKGLFVKELEEAMLDGRADLAVHSMKDVPMEFPEGLGLVAICEREDPTDAFVSNQYEHIDQLPEGAVVGTASLRREAQLRANRPDLQIKVLRGNVNTRLAKLDAGEYDAIVLASSGLKRLGFHDRIRYCLPDTFSLPAVGQGALGIECRVGDTELLELIDPLNHTDTWDRVSAERALNRRLEGGCQVPIAAYALLEDDNTLWLRGLVGAVDGTQIFRVEGRAPRAEGERLGRELAEQLLSMGADKVLAEIYGHTPR
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: C11B1_RAT
Sequence: MALRVTADVWLARPWQCLHRTRALGTTAKVAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPHRMPLEPWVAHRELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAIQSFVPFVDVVARDFVENLKKRMLENVHGSMSINIQSNMFNYTMEASHFVISGERLGLTGHDLKPESVTFTHALHSMFKSTTQLMFLPKSLTRWTSTRVWKEHFDSWDIISEYVTKCIKNVYRELAEGRQQSWSVISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIVANPQKAMSDLPLLRAALKETLRLYPVGSFVERIVHSDLVLQNYHVPAGTFVIIYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMVFRFLLMPSSSPFLTFRPVS
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids.  Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule.  Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
What are the official names of this protein?
Cytochrome P450 11B1, mitochondrial, CYPXIB1, Cytochrome P450(11 beta)-DS, Cytochrome P450C11, Steroid 11-beta-hydroxylase, CYP11B1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein.
Protein: BCRB_ENTFL
Sequence: MLNLISCELSKLKRSKMVLISVAGVLSTPLLMLIEALQTHFDKPEIIFTLSDIYSDSVLYIMLLVNMMIYVAIAAYLYSREYTENTLKTILPIPISRTKLLIGKFCTLLLWIVMLTLVTWAGIFIVCGLYHVVFTLEGYSLLVAISWLPKFLFGGILMFLTTSPFVFIAFKTKGFVAPVIASAVIVMGSVALSNQELGALYPWTATFFLIDGRIESTGYPLALAIGIIILVSAVGFFMTFHHFKKEDLK
What is the function of this protein?
Essential for high-level bacitracin resistance (PubMed:15388429).  Part of the ABC transporter complex BcrAB.  Probably responsible for the translocation of the substrate across the membrane (Probable).
What are the official names of this protein?
Bacitracin transport permease protein BcrB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DPO3B_CHLPN
Sequence: MKFVVSRNELGNLIKKIQSVVPQNTPIPVLTHVLIETYNDELVFTATDLTVSTRCVTKAKVYEKGAISIPSKRFFQLVKELTEANLEISSSAGEMAQITSGSSCFRLLSMEKEDFPMLPDIQNALRFSLPAEQLKTMLQRTSFAVSREESRYVLTGVLLAIANGVATIVGTDGKRLAKIDAEVTLDKSFSGEYIIPIKAVEEIIKMCSDEGEATIFLDQDKIAVECDNTLLITKLLSGEFPDFSPVISTESNVKLDLHREELITLLKQVALFTNESSHSVKFSFLPGELTLTANCTKVGEGKVSMAVNYSGELLEIAFNPFFFLDILKHSKDELVSLGISDSYNPGIITDSASGLFVIMPMRLHDD
What is the function of this protein?
Confers DNA tethering and processivity to DNA polymerases and other proteins.  Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA.  Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity.  The beta chain is required for initiation of replication as well as for processivity of DNA replication.
What are the official names of this protein?
Beta sliding clamp, Beta clamp, Sliding clamp, Beta-clamp processivity factor, DNA polymerase III beta sliding clamp subunit, DNA polymerase III subunit beta.
What is the protein family that this protein belongs to?
Belongs to the beta sliding clamp family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTS_PLEWA
Sequence: GNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, alpha skeletal muscle.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: AKR1_ORYSJ
Sequence: MAAAAMATVAVPRVKLGSQGMEVSAQGLGCMGMCPAFEPPKPEADMVALIRHAIAAGVTFFDTSDLYGPHTNEVLLGKALQGGGVRDRVELATKFGKFFAGGKPGIRGDPAYVRAACEGSLRRLGVDCIDLYYQHRVDKKVPIEVTIGELKKLVEEGKIRYIGLCEASASTIRRAHAVHPITAVQLEWSLWSRDVEEDIVPTCRELGIGIVAYSPLGKGFFSSGAKLVDSLPDHDFRKLIPRFQPGNIEKNAEIFERVNEMAARKGCTPSQLALAWIHHQGRDVCPIPGTTKIENFNQNVAALSVKLTPAEMAELESYASNVHGDRYPLMMANTTWQDSETPPLSSWKSE
What are the official names of this protein?
Probable aldo-keto reductase 1.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: INTU_DROME
Sequence: MRKSPASLPSEAFSSSNSSLSNSYSDGSDLANWEEYVSTDGSLFYMEYVRCEKTGVSAERRVEFMRRSLRLGKKSSRRQPHSNNQNQSQNQNQSHGPSRLDSQTEPQEFRFSQFKTAAPDPKKLDLVITAADRFRFGRRSTAVESILGFRVLPFPDQPECLMVDGFVHDVSALQHGIKRGDWFRSLNGIEVYASNVDELLKQFVEPTQVCLGFQSCGAASAVSPTDPGYNRNVREEQVCKVENFPMFTEKFEQMLITEGNFGIPGSSVDIRMPFAMLLLPPECYQHEQQQDSLYYFPEIPDNFLFKARGSFLTLHAVLSELHTQPLSSRLLVDQVQYHVNYRQLNGFLVLFAYAGGLCCAAECSLRSDELIGYIRFSLPGLVLESFNQEREPGNSSRLKLFLRHFCEIQRTRLVARCHGHIRFEELLGQSRSLPLPKEAQLRIFDALSEMEAMDYRNWNDEPLTTHREFFIYGSALYYDGFLVASLLPPEVRVSVEGFLRCRGIFELLGAAPGIKVREMYVWEEIVLPSATGRYFLTICTKNHLSLAVILKIFDAPDMAPDAVVGPSLFYIEEIQETLDHLVQCGIESLAMFWSVSNKRPEVLDATASESRDQEKEPNNRLESFLKQKLTVLSPSVEEEAQLCSSLGGSSIHSLTPSEDESCRRRLTPIHGTAEDSDSGSDWENFAVQHPLHYGLNLGAESHSQSQMTESMWKEINNVVPVKISAGWKNSVLHYVYIDIANGSLFAPFTDSSENSNYLSEIRQACHIIHAVLQKSKHYRRHLSESSRAQTNSNGHSSHTVSLVKEHGMILEVSTQPKSDGQSQSSTSSRFVVVGRLFQSPAKEVYVCHRSDVPQNIVEMAFRLSFFSMG
What is the function of this protein?
Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade.  Acts downstream of fuz and accumulates asymmetrically in wing cells to regulate planar polarity in the wing.  Probably acts by regulating ciliogenesis.
What are the official names of this protein?
Protein inturned.
What is the protein family that this protein belongs to?
Belongs to the inturned family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Localizes in the vicinity of plasma membrane and the cortical actin cytoskeleton of wing disk and pupal wing cells (PubMed:10570461). Localizes to the proximal side of wing cells, fuz and frtz are required for its localization (PubMed:15556868).
Protein: GCSH_CHRSD
Sequence: MSHIPANLRYTDSHEWVLDNGDGTVTIGITDHAQEALGDVVFVELPETGRELDAGEEFGVIESVKAASDLYLPLSGEIIAVNESLEDAPETVNDNPYEDGWIIKLKLAEPEALESLLDATAYDALVSAEED
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: AROB_DEHMB
Sequence: MKSIGLNLSGREYKILIGSDLLSETATLLREAIPCDRVVVITNIDINRIYGKKLKKHLESKGIESLFLELPEGEIHKTLDMAAHIYPQLINHFAERNTPILALGGGVIGDLSGFVAATYQRGVPLIHLPTSLLSQVDSSIGGKVAVNHGGVKNIVGSFYQPRLVIADTGCLKTLPEKEFACGMAEIIKSAAIGSSELFRMLETNTQAVKDRSPEVMEDIISQTAAIKAGIVCQDETDRGIRNILNFGHTLGHALESTSSFSQSHGAAVAIGMCFAARLSVRLGLCENETALRLEKLIADFGLPTNPKDIDPDKIIEAMHHDKKVSDGRIRFILLKRPGEALIAENILKPDVLSVLEEMK
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPD_ACIBT
Sequence: MSQLSTIIEQAFEDRANFTAADCPSEIRQAVEEAIAGLDNGTLRVAEKINGEWVVHQWLKKAVLLSFKLNDNKPIESCDLRFYDKVETKFSGWTEEQFKAAGVRVVPPAVARRGSFQAKNVVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEIVEGVIVEEGSVISMGVYIGQSTRIYDRETGEIHYGRVPAGSVVVPGNLPSADGKYSLYAAIIVKKVDAQTRAKTSLNDLLRAD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_GEOSE
Sequence: MSYRKLGRTTSQRKALLRDLATDLIINERIETTEARAKELRAVIEKMITLGKRGDLHARRQAAAFIRKEVANSETGQDALQKLFSDIAPRYQDRQGGYTRIMKLGPRRGDGAPMVIIELV
What are the official names of this protein?
50S ribosomal protein L17, BL21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: ARLMC_PYRHO
Sequence: MEMRGKITKINENGLGVLGNILVPFAYPGDEVEVTETRERFGKIIARDFKLMTPSPLRIPGKCSHFGKCGGCLWQGLRYREQLKLKEEIFKRITGIEAEIKGSPRIWYFRNISNFIITVNGIGFKEFGMPKTVVNIRECPIFSERTPKYLKALKDFLRESNLKPWNWREGDVHYLQVREGKFTGEVMVNIIAHVPLNYREALMEAFNFADSIYWSLKADKKDDPRGFPTLVLGNEVIREKVEGITYLIHPSVFFQTNSYALPLLLKSVEKFCEGSKVLDLYSGIGTLSLYLAKRGFEVTGVEVNGTSVEMAKRSAEINSINATFIQGKAEDAELEGYETLIVDPPRKGLKEFSRRIVKKGPNTLIYVSCNPLRFILDYRNYLSEAYKVDDALLIDMFPHTPHIEAVIKLVRR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position equivalent to 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: SYGA_SYNSC
Sequence: MYFQDIISTLNRFWADQGCLLLQPYDTEKGAGTMSPHTVLRAIGPEPWAVAYPEPCRRPTDGRYGDNPNRAQHYFQYQVLIKPSPDGIQETYLASLEALGIKAADHDIRFVEDNWESPTLGAWGVGWEVWLDGMEVTQFTYFQQCGGIDCKPVSIEITYGLERLAMYLQDVESIWDLSWNSERSYGEIWLPFEKGQCHFNFEASNPERLKQLFAIYEAEAADLIEKQLPAPALDFVLKCSHTFNLLEARGVISVTERTATIVRIRNLARKVAEAWLAEREALGFPLLKGGTLETAA
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_STRPB
Sequence: MSSGKIAQVVGPVVDVMFASGDKLPEINNALIVYKDSDKKQKIVLEVALELGDGMVRTIAMESTDGLTRGLEVLDTGRAISVPVGKETLGRVFNVLGETIDLEEPFAEDVDRQPIHKKAPSFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTQKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLTQMGIYPAVDPLASSSRALSPEIVGEEHYAVATEVQRVLQRYRELQDIIAILGMDELSDEEKTLVGRARRIQFFLSQNFNVAEQFTGLPGSYVPVAETVRGFKEILEGKYDDLPEDAFRSVGPIEDVIKKAEKMGF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: THIC_FRACC
Sequence: MVSRTDRSSSSTSKAVTSSPSTSSLSSAASSPSVSSSSSSSSVSAAGMTAVSTGPLTGSRKTWLVGADPDLRVPMREIVLTTGDTVVVYDTSGPYTDPGVTIDVRRGLPATRDSWIAQRGDTAPDERRTVPGTGASGPGTLGSGTPGSGTPGSGPLGLGGTDLDGRVRVPRRAVPGRPSITQLGYARRGQITREMEFVALREGLPVETVRAEIAAGRAVLPANVNHPESEPMAIGRAFLVKINANLGNSAVTSSIEEEVEKMVWATRWGADTVMDLSTGSDIALTREWIIRNAPVPVGTVPIYQALEKVGGRPEKLSWEVYRDTVIEQCEQGVDYMTVHAGVLLRYVPLTARRRTGIVSRGGSILASWCLAHHEENFLYTHFAELCEIFAAYDVTFSLGDGLRPGSIADANDEAQLAELATLGELTQVAWEHDVQVMIEGPGHVPMNKIEENVQLQRELCHDAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWAGTAMLCYVTPKEHLGLPDRDDVKAGVIAYKIAAHAADLAKGHPGAQAWDDALSDARFEFRWADQFHLALDPDTARAFHDETLPAPAAKSAHFCSMCGPHFCSMKISHQVRAHAGGDGLDPAGHGADPAGDEAVTAGLREKAAEFNAAGNRIYLPVANS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: Y664_MYCPN
Sequence: MRVAFLVDSVSNLKESQAQHLYVLPLFIIESTPEAETTFSSGFDIDLKTLTDKMANAPKGVKFSTSQTTEEIVRAKVSELVEQYDLIIGIPIDKEISASYANWKLVEKDYASKFHVLDARAVEMIIDWLINDIKGWLNTNPYSREGLDRFVEQYRKKTAAVLFVTDTKPLVAGGRLSNLKSFIIKSLKFHLLISFLGENGKLQFFDKARSAHDAHKLAVKFLKKQLLKHSAKLKRGAFLTTVFDEQTNTNLVQEFDKLLDHSINIEQSLLSPVICTHTGLNSYVIVLQGE
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein MG450 homolog.
Protein: ARLY_HALSA
Sequence: MTGGGDPVVRRDRFSGGPARSFLSSMDGDGRIFEADLAVDRAHVVMLAEQDVIGDEAAAAILGALADVEAAGFDALPPGEDVHEAIETAVVEAVGRDGGKLHTARSRNDEVAACIRYRLRADLLDAIEVVVALRSALADVAAAEAETVMPGFTHLQPAQPTTVAHWALSYAGTLARDTGRLCDAYGRTNESPLGAAAFAGTTFGVDRERTAALLGFDGVVANAADAAASRDFLLEAVSALASVAVTCSGLAADVVFFANRGFVEVSDDYASTSSIMPQKKNPDTMELVRATAGDAVGAQQALATTLQGLPRAYNRDLQRATGHAWTAVDGVTSAVEVAAGVVATAGWPADDLEAAAGEGFSTATGVADALAAGGLPFRTAHEVVALAAERGCEGATLDAVAAATEAVTGEPLSAVVEPAAVADALDPVGSVAARDSAGGPAPAAVEAAVADVRDGIDADEAALAAERASLADAADALAAEVSGYV
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NQOR_GEOUR
Sequence: MKVLIAYYSMYGHIHRMAEAVAEGAREVAGAEVLIRRVPETLPADVLEKMGAVETQKKMAQIPVCTIGELADADAIIFGTPTRFGNMCGQMRQFLDATGGLWMKGSLVGKLGSVFTSSATQHGGQESTILSFHITLLHQGMVVVGLPYAFQGQMRNDEIIGGSPYGASTIAGTQGERSPSENDLAAARYQGKHVASIAARLAR
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.
Protein: ENGB_RHIL3
Sequence: MPETEKPLFGHPWIFIRGVPSLNFLPPEGPLEVAFAGRSNVGKSSLINALVGQKGLARTSNTPGRTQELNYFVPDGYSGEGGDLPPTAIVDMPGYGYAQAPKEQVDKWTKLVFDYLRGRATLKRVYVLIDSRHGIKKNDDDVLDLLDKAAVSYQIVLTKTDKIKAAGVPKLLAETAEKIRKRPAAYPGVLSTSSEKGDGLDELRQAIAETVGIARWK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: ACPS_ECOLI
Sequence: MAILGLGTDIVEIARIEAVIARSGDRLARRVLSDNEWAIWKTHHQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPRLRLWGEALKLAEKLGVANMHVTLADERHYACATVIIES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to the 'Ser-36' of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FAU1_IGNH4
Sequence: MEKPRVRVRGIYATAVAKVLLDEGLELSDLSKKLKERIGHEGSPEPPHVTVKQSDDNPDQLVIIGFPEETDKVIQTLRKSMPYSVHHLARPNLHSAYVVEVDEECRTKLGEEEVRVKAKECYDGKKLIAEVVRSRVFPTDKLVMEEGFRVIGLYAELVIGRGSGVTFSKHITDLETKMLLMNLAAEVVRRGVKVHWRSSAKKAEPQVLLEELEKLYDEATKIMVKARDADHGTEVYPGERLDVVELTLEDKVILDEIRSKVVPTMPYHHSLKSGGDRMAAAVELGDKIAASSEVKAESVIDYIIDLARDMKYLNIIHKKVDGAEYSLGRARVRGNVDNYLVLERRSKDYGKYDGLDVVKEPGDLMITLVSPFSRYLIHAYYDQYGNEKGIYVNVNTGVEVGEGNVRYIDLEVDIIHKDGEWSVIDEDGLDRLPAPLRELAVAEVEKLLSHPDRIKEVVANARELLSAQL
What is the function of this protein?
Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs.  Binds to RNA in loop regions with AU-rich sequences.
What are the official names of this protein?
Probable ribonuclease FAU-1, RNA-binding protein FAU-1.
What is the protein family that this protein belongs to?
Belongs to the FAU-1 family.
Protein: PDE11_RAT
Sequence: MAASRLDFGEVETFLDRHPELFEDYLMRKGKQELVDKWLQRHSSGQGASDLRPALAGASSLAQSSARGSTGIGGGAGPQGSANSHPASGGGESAGVPLSPSWASGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPQYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSTTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRNSDGEIIGVAQAINKVPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESVEKSSYSDWLINNSIAELVASTGLPVNVSDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGAYDWSITSHRDVFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNAKLKPMLDSVAANRRKWEELHQKRLQVSAASPVPSSPSPAVAGEDRL
What is the function of this protein?
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:11502204).  Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:11502204).
What are the official names of this protein?
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: ENOPH_PICGU
Sequence: MKTECRELFAMTVILDIEGTVCPITFVKDTLFPYFLEQLHPILSSLQFPLDKADPVANICSQFPSHVQQDETSLITYIRQLVASDTKDPVLKSLQGLVWKKGYDNGDLVAPIYDDAIALITTSSEPIYIYSSGSVAAQKLLFSHVKGNLDLTPHLAGYFDITTSGHKQDSTSYKSILHAIGNPEPATVTFYSDSPAEVRAAIEAGMKATIVVRPGNGPLTDQDRQLGTITSFP
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.