PharMolix/UniProtQA huggingface dataset:
Protein: FENR_EHRRW
Sequence: MVDYVTDIVVIGAGPIGIFTVFQSGMLSMQCCVIDSLNEIGGQCVALYPEKPIYDIPAYPIITAKELINNLVEQSKPFDPQYLLGQVAEKIEEYIDYLLVKTNYGTVIQCKAIIIAAGSGAFGPNRLPVDNIIDFENKSVFYSVKQISDFYDKSVMIAGGGDSAADWAVELSKVTKQLYMVHRRKNFRCSPNTSLKLDDLFQRGKINLVVPYQIKQLCGKDGKLDYVVVKNITTSEELTLQVDYLLPFFGTSANLGPILNWGITISGYQIVIDPATCRTNRNRIYAVGDVSTYPGKIKLILTGFSESAMACHDIYHIVYPNSPLNFQYSTSKGIPKV
What are the official names of this protein?
Ferredoxin--NADP reductase, FNR, Fd-NADP(+) reductase.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: RS20_RUEPO
Sequence: MANSPQAAKRARQNEKRFAINKARRSRIRTFLRKVEEAIASGDKDAATAALRAAQPELMRGVSKGVFHKNTASRKMSRLSSRVKALG
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: RR19_NYMAL
Sequence: MARSSKKNPFVANHLLSKIEKLNKAEERSIIVTWSRASTIIFAMVGHTIAVHNGKEHLPIYITERMVGHKLGEFAPTLTFRGHARNDNRSRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PCRB_ALKCK
Sequence: MKNYDEWAHVFKLDPNKEITDEALEAVCESGTDAIIVGGTDNVTLDNTLSLFARIRRFPVTCALEVSDLEAITPGFDYYLIPSVMNSQHVSWVIGHHHKAVKEYGEIINWQELLLEGYCVLNGEARVANHANAQTDLDIEDVVAYARLAEHMYRYPFFYLEYSGKKGPIDVVKRASAVLEKTKLIYGGGIKNAADASEIAAYADVVVVGNGLYENLKEALKTVEAVKEHKCR
What is the function of this protein?
Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP).  This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.
What are the official names of this protein?
Heptaprenylglyceryl phosphate synthase, HepGP synthase, Glycerol-1-phosphate heptaprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
Protein: RSMA_CHLFF
Sequence: MALGDLLSRSSPDQLTRFLAQVHGHPKKGLSQNFLIDGNILRKILAVSCVEAGDWVLEIGPGFGALTEVLVNQGAHVVALEKDPMFEETLKQLPIDLEITDACKYPLSQLQEKGWQGKGRVVANLPYHITTPLLTKLFLEVPNQWKTITVMMQDEVARRITAQPGGKEYGSLTIFLQFFADVRYAFKVSSGCFFPKPQVSSAVVHMTVKDTFPLEESLHKKFFSLTRAAFGQRRKLLANALKNLYPKDLVFSALNQLNFSEKTRPETLSLDEYLKLFQLLSLNS
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BMP5_HUMAN
Sequence: MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
What is the function of this protein?
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139).  Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864).  In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864).  Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566).
What are the official names of this protein?
Bone morphogenetic protein 5, BMP-5.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: CAMT_ZINVI
Sequence: MATPTGETQPAKHQEVGHKSLLQSDALYQYILETSVYPREPQPMKELRRITAKHPWNLMTTSADEGQFLNLLLKLINAKNTMEIGVYTGYSLLSTALALPEDGKILALDINRENYEIGLPIIQKAGVAHKIDFREGPALPLLDQMLQDEKCHGSFDFIFVDADKDNYLNYHKRLIDLVKFGGVIGYDNTLWNGSLVAPADAPLRKYVRYYRDFVLELNKALAVDPRVEICQLPVGDGITLCRRIS
What is the function of this protein?
Methylates caffeoyl-CoA to feruloyl-CoA and 5-hydroxyferuloyl-CoA to sinapoyl-CoA.  Plays a role in the synthesis of feruloylated polysaccharides.  Involved in the reinforcement of the plant cell wall.  Also involved in the responding to wounding or pathogen challenge by the increased formation of cell wall-bound ferulic acid polymers.
What are the official names of this protein?
Caffeoyl-CoA O-methyltransferase, Trans-caffeoyl-CoA 3-O-methyltransferase, CCoAMT, CCoAOMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. CCoAMT subfamily.
Protein: EIF3J_RAT
Sequence: MAAAAAAAAGDSDSWDADTFSMEDPVRKVAGGGTAGGDRWEGEDEDEDVKDNWDDDDDENKEEAEVKPEVKISEKKKIAEKIKEKERQQKKRQEEIKKRLEEPEESKVLTPEEQLADKLRLKKLQEESDLELAKETFGVNNTVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEALVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.  This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site.  It may regulate the interaction between the 43S PIC and mRNA.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit J, eIF3j, Eukaryotic translation initiation factor 3 subunit 1, eIF-3-alpha, eIF3 p35.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit J family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMY_TENMO
Sequence: QKDANFASGRNSIVHLFEWKWNDIADECERFLQPQGFGGVQISPPNEYLVADGRPWWERYQPVSYIINTRSGDESAFTDMTRRCNDAGVRIYVDAVINHMTGMNGVGTSGSSADHDGMNYPAVPYGSGDFHSPCEVNNYQDADNVRNCELVGLRDLNQGSDYVRGVLIDYMNHMIDLGVAGFRVDAAKHMSPGDLSVIFSGLKNLNTDYGFADGARPFIYQEVIDLGGEAISKNEYTGFGCVLEFQFGVSLGNAFQGGNQLKNLANWGPEWGLLEGLDAVVFVDNHDNQRTGGSQILTYKNPKPYKMAIAFMLAHPYGTTRIMSSFDFTDNDQGPPQDGSGNLISPGINDDNTCSNGYVCEHRWRQVYGMVGFRNAVEGTQVENWWSNDDNQIAFSRGSQGFVAFTNGGDLNQNLNTGLPAGTYCDVISGELSGGSCTGKSVTVGDNGSADISLGSAEDDGVLAIHVNAKL
What are the official names of this protein?
Alpha-amylase, 1,4-alpha-D-glucan glucanohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family.
Protein: ATPA_BURO1
Sequence: MQLNPSEISELIKSRIQGLEASADVRNQGTVISVTDGIVRIHGLSDVMQGEMLEFPGNTFGLALNLERDSVGAVILGEYEHISEGDIVKTTGRILEVPVGPELVGRVVDALGNPIDGKGPVNAKLTDAIEKIAPGVIWRKSVSQPVQTGIKSIDAMVPIGRGQRELIIGDRQCGKTAVALDAIINQKGKDLICIYVAIGQKASSIMNVVRKLEETGAMEYTIVVAASASDSAAMQYLAPYAGCTMGEYFRDRGQDALIIYDDLTKQAWAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVSEEYVEKFTNGEVKGKSGSLTALPVIETQAGDVTAFVPTNVISITDGQIFLETDLFNAGIRPAINAGVSVSRVGGAAQTKVVKKLSGGIRTDLAQYRELAAFAQFASDLDEATRKQLERGRRVTELLKQPQYQPLQVWELAVSLYAANNGYLDDLDVKQVLPFEKGLRDNLKTSHADLIKRIEDTKDLSKDDEGALRSAIEAFKKSGAY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: RS3_HELAH
Sequence: MGQKVNPVGLRLGINRNWTSRWFPSARTAPSNIDEDNKIRKFLKKELYYAGVSQIVIERAAKKLRVTVVAARPGLIIGKKGVDIEKVKEGLKTLIKKEVSINIKEVKRPQADAQLAAENVATQLEKRVAFRRAMKKVMQAALKSGAKGVKVRVSGRLAGAEIARTEWYMEGRVPLHTLRAKIDYGFAEAMTVYGIIGVKVWIFKGEVLQKGIQFEKKEEVKEEREPRRSRRGRQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PRA1_SCHPO
Sequence: MSALSLSITKVSETFSEIYASRAQYLSGFKSVGEFLDVRRISRPRNFSEAQSRISFNFSRFSSNYLAIIAMLVIYALIRNPLLLIVIGIGVGGVYGIRKLQGADLQLSHRVISNQNLYVILACVLIPLGLFASPIETIIWLVGASCVCVFGHAAFFEPPVESAFETVEQQV
What are the official names of this protein?
PRA1-like protein.
What is the protein family that this protein belongs to?
Belongs to the PRA1 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TTGG_PSEPT
Sequence: MRAERWSQTVRQIRSPRALRVIPLTALMLISGCGEKEQVSSATPPPDVGVYTVRAQALTLTTDLPGRTSAFRVAEVRPQVSGILQKRSFVEGAEVKLGQQLYQIDPRTYEAQLRRAEANRTSAQNLARRYETLLKTKAVSKQQYDDALAAWKQAEADYQVARIDVQYTRVLSPISGRIGRSTVTEGALVTNGQAQSLATVTQLDPIYVDVTQPITKLLGLQKALESGRLQKTGENQAEVSLTLDDGSAYPLPGTLKFSEVSVDPTTGSVTLRAEFPNPNRKLLPGMFVHALLKEGVQNAAILVPQQAISRDTRGVPSVWVVKADNTVESREIQTLRTVGNAWLISNGVTEGERIITEGVQRVRSGIAVNAVEAKNVNLVDGFAATTEASAN
What is the function of this protein?
The periplasmic linker component of an organic solvent efflux pump.  Involved in export of a number of organic solvents, including toluene and styrene.  This is the most important solvent efflux pump in this strain, although it can export AMP and some antibiotics.
What are the official names of this protein?
Toluene efflux pump periplasmic linker protein TtgG.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Lipid-anchor.
Protein: RL16_ECOHS
Sequence: MLQPKRTKFRKMHKGRNRGLAQGTDVSFGSFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGKVLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: TTCA_ANADF
Sequence: MRAPRRRCYRVRPMHDVSKLEKRLLRAAANAIRDFELIGDGDRIMVAVSGGKDSYTLLHVLMRLRERAPIDFDLVAVNLDQGQPGYPAEIVERHFQAVGVPHRMLYADTYSIVRRLVPEGKTTCPVCSRLRRGVLYNAAAEMGCTKIALGHHRDDLVETLLLSALYSGALKSMPPKLRSDDGRNVVVRPLCYAAEEDIAAFATAMRFPIVPCDLCGSQPNLRRKRVKALLAELSDEHPAVKGNLLNALGHVVPSHLLDRDLHRLVASTGRDPWLDGDEDEDGGCLQGEVADALVKLAGAREDA
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFP_BUCAP
Sequence: MRVYHSNNFRSGRKIIFEKEPCLIESSEFVKPGKGQSFVRVKLRKLLTKQLIEKTFKSTDSLEIADVSEYTLSYLYNDGHFWYFINNNFEELSVDKKIVGVNKKWLSEQDTCVITFWNNQAISITPNIFVELKVIDTEIALKSDTINTTTKLATLSTGAILKVPLFIQIGSLIKVDTRSGEYVSRIK
What is the function of this protein?
Involved in peptide bond synthesis.  Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome.  Modification of Lys-34 is required for alleviation.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_STAAR
Sequence: MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNVEVQAVVKYAYQNEIPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALTGLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLVKLTTKELELDYRNSIIQKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLIQDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRIIGEHPKES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVB31_ARATH
Sequence: MDALTSSLVRSPIVPSRTSDNGSGSMFLTASGPGFTRSGSSRLQLRLRQNASARSSRSLQSLTTTAKTRRSFVVRASSASNDASSGSSPKPIAPLQLQSPAGQFLSQILVSHPHLVPAAVEQQLEQLQTDRDSQGQNKDSASVPGTDIVLYRRIAELKENERRRTLEEILYALVVQKFMEANVSLVPSVSPSSDPSGRVDTWPTKVEKLERLHSPEMYEMIHNHLALILGSRMGDLNSVAQISKLRVGQVYAASVMYGYFLKRVDQRFQLEKTMKILPGGSDESKTSVEQAEGTATYQAAVSSHPEVGAFAGGVSAKGFGSEIKPSRLRSYVMSFDAETLQRYATIRSREAVGIIEKHTEALFGKPEIVITPEGTVDSSKDEQIKISFGGMKRLVLEAVTFGSFLWDVESHVDARYHFVLN
What are the official names of this protein?
UV-B-induced protein At3g17800, chloroplastic.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AL5AP_HUMAN
Sequence: MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
What is the function of this protein?
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase).  Anchors ALOX5 to the membrane.  Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5.  Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
What are the official names of this protein?
Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein.
What is the protein family that this protein belongs to?
Belongs to the MAPEG family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PYRD_SYNY3
Sequence: MLRFARSLYPLILSVTKSDPERGHQRLIQTLKKVDTMHRNGFAVAMEQLEQAFTHADPRLQQTCWGLNFPNVLGLSAGCDKEGEAAAVWPALGFGFAELGAVTKYAQPGNDRPRLFRLPQDQAVLNRLGANNEGAVAMAAKLKHTWDYYPRTIPIGINLCKSKITPLDQAVEDYVFSFQTLAPVADYFVVNVSSPNTPGLRSLQESDELPRIFAGLQSANHWQKPLLVKISPDLSWEAIAVIIDLVKEHNLSGIVATNTSTRRSGLKTKILPQTGQPIEQEAGGLSGQPIRDRATEVIRYIYQQTGGTIPIIGVGGIFTAEDAWEKIQAGASFLQIYTGWIYGGPWVVSDILQGLGEKLAAGGFSHISEAVGIDTIGKAPE
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PYRC_BACCL
Sequence: MGVWLKNGMSFNKDGELMRTHIKIEHGTIAAILYEQPLEANEDVIDVGGRLIVPGLIDLHVHLREPGGEAKETIETGTLAAAKGGFTTVAAMPNTNPAPDRKEQMEWLQARIRETARVNVLPYAAITIGQKGEELTDFAALKEAGAFAFTDDGVGVQSAGMMFEAMKQAAALDMAIVAHCEDDTLTNGGAVHDGEFARRYGLRGIPSVCEAVHIARDVLLAEAAGCHYHVCHISTKESVRVVRDAKRAGIRVTAEVTPHHLLLCDEDIPGLDANYKMNPPLRSREDRDALIEGLLDGTIDFIATDHAPHTAAEKAKGIEAAPFGIVGLETAFPLLYTHFVKTGVFTLKQLVDWLTIKPAQCFGLKAGRLAVGAPADIAVIDLETEEAIDPETFASKGKNTPFAGWVCQGWPVMTFVGGTLVWEKGRA
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: RBY1A_HUMAN
Sequence: MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDRTSKSRGFAFITFENPADAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATNDGNHPSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGRSWESYSSCGDFHYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGDSSRY
What is the function of this protein?
RNA-binding protein involved in pre-mRNA splicing.  Required for sperm development.  Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN.  Binds non-specifically to mRNAs.
What are the official names of this protein?
RNA-binding motif protein, Y chromosome, family 1 member A1, RNA-binding motif protein 1, RNA-binding motif protein 2, Y chromosome RNA recognition motif 1, hRBMY.
What are the subcellular locations of this protein?
Nucleus.
Protein: 3SAC3_NAJSP
Sequence: DKCNKLVPLFYKTCPAGKNLCYKMFMVSDLTVPVKRGCIDVCPKNSALVKYVCCNTDRCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin KJC3.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: TAL_STRPF
Sequence: MKFFLDTANVAAIKAINELGVVDGVTTNPTIISREGRDFETVIKEICDIVDGPISAEVTGLTADAMVEEARSIAKWHDNVVVKIPMTTEGLKATNILSKEGIKTNVTLIFTVSQGLMAMKAGATYISPFIGRLEDIGTDAYQLISDLREIIDLYDFQAEIIAASIRTTAHVEAVAKLGAHIATIPDPLFAKMTQHPLTTNGLKTFMEDWASFKK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXA_MYCTU
Sequence: MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTT3_ALTAL
Sequence: MLNRFSYSSNAWHNLRVDGPDADGIAVIVLARSQSRNALTLPMLTDMVQLLSAMDADDSVKCIVFTGEGQFFCSGVDLTEGFGEIGKTRDTHRDAGGKLALAIHNCRKPTIAAINGTAVGVGITMTLPMSIRIAAESAKISFPFVRRGIVADAASSFYLPRLIGYGRALHLFTTGALYPAESGLLHGLFSETVNPASSTLPRALEVARDIAVNASQVGVYLTRDLIYRSLRSPEQAHLLESATLYTRYQSQDFEEGVKSFLEKRRPRFQDTMHEQSGEGVLERGDCVVSLASKPKL
What is the function of this protein?
Enoyl-CoA hydratase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) ACT-toxins responsible for brown spot of tangerine disease by the tangerine pathotype which affects tangerines and mandarins (PubMed:18944496, PubMed:18986255).  ACT-toxins consist of three moieties, 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA), valine and a polyketide (PubMed:22846083).  ACT-toxin I is toxic to both citrus and pear; toxin II the 5''-deoxy derivative of ACT-toxin I, is highly toxic to pear and slightly toxic to citrus (PubMed:22846083).  On cellular level, ACT-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The acyl-CoA ligase ACTT1, the hydrolase ACTT2, the enoyl-CoA hydratases ACTT3 and ACTT6, and the acyl-CoA synthetase ACTT5 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety (PubMed:18944496, PubMed:18986255, PubMed:19271978).  The exact role of each enzyme, and of additional enzymes identified within the AF-toxin clusters have still to be determined (PubMed:18944496, PubMed:18986255, PubMed:19271978).  On the other hand, ACTTS1 to ACTTS4 are specific to the tangerine pathotype (PubMed:22846083).  The function of ACTTS3 is to elongate the polyketide chain portion of ACT-toxin that is unique to this toxin (PubMed:20192828).  The enoyl-reductase ACTTS2 might complement the missing enoyl-reductase (ER) domain in ACTTS3 in the synthesis of the polyketide portion of ACT-toxin (PubMed:20055645).  The roles of the nonribosomal peptide synthetases-related proteins ACTTS1 and ACTTS4 have also still not been elucidated (PubMed:22846083).
What are the official names of this protein?
Enoyl-CoA hydratase ACTT3, ACT-toxin biosynthesis protein 3.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Peroxisome. Note=The peroxisomal location requires the C-terminal tripeptide peroxisomal targeting signal.
Protein: CAZA2_PAPAN
Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.