PharMolix/UniProtQA huggingface dataset:
Protein: AROC_ECO55
Sequence: MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLEIKDWSLVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: LONH_THEAC
Sequence: MGTFFVDFYNEYPDTSYIKIPTNPLDRVIGQDDAVKIAMVAAKQRRHLLLVGPPGVGKSMIAQAMSFYIDRPTEEIRVVHNPQYPERPFVEIKTREEVMAEREEETSTSGIIIDPKDAPTSVAERLGYRCSKCGFYSSPSDAVCPNCNSPKIQMGTQGPFGDVFNVIGAAFGVQNNLDKVTLTRRNGDHDEIIVYERYNDKIRVLDEKTLERRRRLEKKSPSKTIVPIDRNPFVLATGASETELLGDVRHDPYGGHPQLGTLPYERVIAGAVHEAHQGVLFIDEITHLGNLQRYILTAMQEKTFPITGRNPQSAGASVRVDKVPADFILVAACNINDLPYILSPLRSRIVGNGYEILMKTTMKDTDENRMKYLQFISQEITMDGKIPHMTMEAAELIIEEGKKRARIIDKKNNELTLRLRELGGLIRAAGDIAVFKGNKLIEKEDVEEAIKLYVPVEEKITKEYGSMAAAYSSENTTSQKDFYNYNLDDRSYE
What are the official names of this protein?
Putative lon protease homolog, ATP-dependent protease La homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
Protein: RL13_SALG2
Sequence: MKTFTAKPETVKRDWYVVDATGKTLGRLATELARRLRGKHKAEYTPHVDTGDYIIVLNADKVAVTGNKRTDKVYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMFRKLKVYAGNEHNHAAQQPQVLDI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ABDH_SALAR
Sequence: MQYQLLINGALVNGEGERQSVYNPATGEVILEIAEASPKQVDAAVLAADNAFTAWGQTTPKVRAECLLELADSIKQNALQLAKLESQNCGKPLHCVINDEIPAIIDVFRFFAGAARCLNGLAAGEYLEGYTSMIRRDPVGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAALAKDIFPPGVINVLFGRGQTVGDALTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELGGKAPVIVFNDADLDAVAQGIRTFGFYNAGQDCTAACRIYAQRGIYDTLVEKLGQAVSSLKMGAPEDESTELGPLSSQAHLARVTAAVEEAKALSHIRVIAGGRQTGGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITAFDDEEQVLRWANESRYGLASSVWTQDVGRAHRLSARLQYGCTWVNTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMIKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: LOLB_TOLAT
Sequence: MKLLQHLTLIFCLLILTACSSRQQQPDNTNWRQQREKLESVTHWTISGKLAIITPEKKGSVRIRWQQNGDDYHLNLTSLLGTRVMEMRKTGEQIVIIDDKGQEYRGTDAEYLVYRLTGWQMPVYKLPMWIKGLPGDTDYQINPNGQVTQIKTAQWQMQYQTYQPVDGWMMPENITFKGQQTELRLVINEWKLAK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: VNS3_AHSV2
Sequence: MNLASISQSYMSHNENERSIVPYIPPPYHPTAPALAVSASQMETMSLGILNQAMSSSAGASGALKDEKAAFGAMAEALRDPEPIRKIKRQVGIQTLKALKVELSGMRRKRLILKIIMFICANVTMATSLVGGISIVDEDIAKHLAFDGKGDWVSKTVHGLNLLCTTMLLAANKISEKVREEIARTKRDIAKRQSYVSAATMSWDGDSVTPLRDVKYGD
What is the function of this protein?
May play a role in the release of virions from infected cells.
What are the official names of this protein?
Non-structural protein NS3.
What is the protein family that this protein belongs to?
Belongs to the orbivirus NS3 family.
Protein: LPXD_PSEF5
Sequence: MTATIKLGQLAEFLGATLSGDGEKEITGLATLQEAGPAQLSFLANPQYRKYLVDCQAGAVLLKAADAEAYAGDALVVADPYLAYARISHLFDPKPKAQAGVHPSAVIAADAQVDPAASIGPFAVIESGARIAAGVTIGAHCFIGARCEIGEGGWLAPRVTLYHDVRIGKRVVIQSGAVLGGEGFGFANEKGVWQKIAQIGGVTIGDDVEIGVNTAIDRGALADTVIGNGVKLDNQIQIAHNVQVGDHTAMAACVGISGSTKIGKHCMLAGGVGLVGHIDICDNVFLTGMTMVTHSITEPGAYSSGTAMQPAAEWRKSAARIRQLDDLARRLRQLEKRVGDVTPGGNASSDG
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: RL25_STAS1
Sequence: MASLKSIIRQGKQTRSDLKTLRNTGKVPAIVYGYGTKNTSVKVDEVEFIKVIREVGRNGVIELGVGSKTIKVMVSDYQFDPLKNQITHIDFLAINMTEERTVEVPVQLVGEAVGTKEGGVVEQPLFNLEVTATPDNIPESIEVDISELEINDSLSVEDIKVSGDFTIENEASDSIVTVVPPTEEPTEEEIEAMEGEAATEEPEVVGEEKEDESGEDQKEE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: DEF66_ARATH
Sequence: MGSSRLMITFIVVAMLAISSDLFSVQIGISVQAAPPTCGRDCTEKFLTQDCDKYCVGLSYKKGVCILSEGLPPKTSTYRCCCS
What are the official names of this protein?
Putative defensin-like protein 66.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPC24_ARATH
Sequence: MGNASENFDIEDLMSYGDDLINLLNVKNGFDIISQSSEQFKALNFACHEDFNQIQGSIEDCKTKLYACKKKTEEAYSDIAAEDEIERLQKELDEEMEREFKLKDELRLVADELKDLNAQLSSIDEHKQSTKRKVRDDLRAEKKLSMYASVTNVIPDIDDPSKISGYMVDREKRLIEKFQFETNKMTAYETCNSIWSIINKQ
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity to ensure proper cell division.  Required for the maintenance of plant architecture.
What are the official names of this protein?
Kinetochore protein SPC24 homolog, AtSPC24, Protein MERISTEM UNSTRUCTURED.
What is the protein family that this protein belongs to?
Belongs to the SPC24 family.
What are the subcellular locations of this protein?
Chromosome, centromere. Note=Colocalizes with CENH3 at the centromere.
Protein: ERPA_CHRVO
Sequence: MTEAATEMPSPINFTESACAKVQDLIAEEGNPDLKLRVFVTGGGCSGFQYGFTFDEIANEDDTAIERQGVTFLVDPMSYQYLVGAEIDYQESLEGSQFVIRNPNATTTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: DNAK_DELAS
Sequence: MGKIIGIDLGTTNSCVAIMDGNTTRVIENSEGARTTPSIIAYQEDGEILVGASAKRQAVTNPRNTIYAAKRLIGRKFDEKEVQKDIDLMPYTISRADNGDAWVEVRGQKLAPPQISAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKTDKGDRKIAVYDLGGGTFDVSIIEIADVDGEKQFEVLSTNGDTFLGGEDFDQRIIDYIITEFKKEQGVDLAKDVLALQRLKEAAEKAKIELSNSAQTDINLPYITADASGPKHLNIKLTRSKLESLVEDLIERTIAPCRTAIKDAGVSVSDIDDVILVGGMTRMPKVQEKVKEFFGKDPRKDVNPDEAVAVGAAVQGQVLSGDRKDVLLLDVTPLSLGIETLGGVMTKMITKNTTIPTKFAQTFSTADDNQPAVTIKVFQGEREMASGNKMLGEFNLEGIPPAARGVPQIEVAFDIDANGILNVSAKDKASGKENKITIKANSGLSEDEIQKMVKDAELNAADDKKKLELVQARNQGEAAVHSVKKSLGEHGDKLDAGEKTAIESAVKDLEEALKGEDKDAIDAKTTALMTASQKLGEKMYADAQAAGGPEAAAAAAAGAAGASAGAAAADDNVVDAEVKEVKKD
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: AGRG7_MOUSE
Sequence: MRSCRSCNVRVLVAIVCGLLTGIVLGLGIWRMVIRINRGIFVPVPSIPVQFCRNGGTWQNGRCICTEEWKGLRCTIANFCENSTDGEFTFGSIPVGRYGPSLQTCEPGTLNAGSPKATRLCNVSEFGNIELQNVTKGSCNINLQTLEIQINNQTASAENISREAQVLTADASKLTAQNITSATTVVGQIFGKANNESQAKKTAIATVSQILDASEDVFQKAAEMDNSKSFSNLIKQMENYSYSQGDQTVVEPNIAIQSVTRDDNSGPSVLFSVQKGSSNSLVSGRILINKTANGLNPDGQTELQILLNTGENRKSCGFMVYQNHKLFQSKTFTATSDFSQKIISSKINESEQQRQNKVSVEMVFNPTYDKRELRLHSYACVYWNFLINDWDTQGCQKTGNTTEFLRCNCSHTTNFAVLMSFKKDYKYPKSLDILSNIGCALSIAGLALTILFQILTRKIRKTSVTWVLVSLCSSMLIFNLLFVFGIENSNKNLKTSDSDINVKPENNKIPESDTIETPNPSCTAIAALLHYFLLVTFTWNGLSATQLYFLLIRTMKPLPRHFIIFISLVGWGVPAIIVGVTIGSIYALSGNKRYWELDYRQEEICWLAVPKDNDYARSPLLWSFIIPVTIILITNITIFVIITVKVLWKNNQNLTSTKKVSSLKKVFSTLSIAVVFGVTWILAYAMLISNDDIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKILKSLSSSFDRTKPMPSITPLKLRVRMYNMLRSLPSLNERFRLLEPSGMTEETSLS
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Adhesion G-protein coupled receptor G7, G-protein coupled receptor 128.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GATA_ANOFW
Sequence: MSLFDYRVSELHSLLHKKEISVSDLVDESFKRIHEVDEKVQAFLTLNEEQARAKAKELDEKLATEKEFGLLFGMPIGIKDNIVTKGLRTTCASKILYNFDPIYDATVVERLNEADAVTVGKLNMDEFAMGSSTENSGFQLTRNPWDLERVPGGSSGGSAAAVAAGEVPFALGSDTGGSIRQPAAFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITRTVEDNAYLLQVISGLDPMDSTSANVDVPDYVSALTGDIQGLKIAVPKEYLGEGVSEEVRQSVLDALKVLEGLGATWEEVSLPHSKYALATYYLLASSEASANLARFDGVRYGYRTDHAKNLMEMYKQTRSEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKQDFENVFEKYDVIIGPTTPTPAFKIGEKTSDPLTMYANDILTIPVNLAGVPGISIPCGFVNGLPVGLQIIGKHFDESTIYRVAHAFEQATDYHKQKPTL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RL23_PYRAE
Sequence: MIKRIVVTEKALRLAEKENKITLIVDRGATKKQIAEEVERLYNVKVEKVNTLITPRGEKKAYVKLTKEHNAMDLLSKLGVL
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: TRA6_GEOSE
Sequence: MITRGEFFMIKEMYERGMSISDIARELGIDRKTVRKYIHSPNPPSKSKRKQRKSKLDPFKPYLQKRMLEDGVFNSEKLFFEIRQQGYTGGKTILKDYMKPFRETAKKKYTVRYETLPGEQMQVDWKEVGEVVIEGKKVKLSLFVATLGYSRMKYAVFTTSQDQEHLMECLIQSFKYFGGVPKKVLFDNMKTVTDGREQGVVKWNQRFSEFASYYGFIPKVCRPYRAQTKGKVERAIQYIMDHFYVGTAFESIEELNFLLHRWLDQVANRKPNATTGISPQERWAEESLKPLPLKDYDTSYLSYRKVHWDGSFSYKGEQWLLSAEYAGKEILVKERLNGDIRLYFRGEEISHVDQQKKVISFAEKIKKKQTEMAATISPVSVEVDTRPLSVYDAFLRGESS
What is the function of this protein?
Involved in the transposition of the insertion sequence.
What are the official names of this protein?
Putative transposase for insertion sequence element IS5376.
What is the protein family that this protein belongs to?
Belongs to the transposase IS21/IS408/IS1162 family.
Protein: RL24_PSESM
Sequence: MQKIRRDDEIIVIAGKDKGKRGKVLKVLADDRLVVGGINLVKRHTKPNPMSGVQGGIVEKEAPLHASNVAIFNGATNKADRVGFKVEDGKKIRVFKSTQKAVDA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: RSMA_BURP0
Sequence: MSNSRQHQGHFARKRFGQNFLVDHGVIDAIVAAIRPERGERMVEIGPGLGALTGPVIARLATPGSPLHAVELDRDLIGRLEQRFGELLELHAGDALTFDFGSIARPGGEPSLRIIGNLPYNISSPLLFHLMSFAPVVIDQHFMLQNEVVERMVAEPGTKAFSRLSVMLQYRYVMDKLIDVPPESFQPPPKVDSAIVRMIPHAPHELPAVDPAVLGEVVTAAFSQRRKMLRNTLGGYRDLVDFDALGFDLARRAEDIGVDEYVRVAQAVASARASG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AGRD1_MOUSE
Sequence: MKDLPAFPCSWVWLLWSFCSVQVCSTQPRAQEHPGFAVLASASHYWPLENVDGILELQDTTGALRTLNLTVPLSHNATFVFTNDSAYSNLSATVDIMEGKVNKGIYLKEEKGVTFLYYGTYKSSCISNPAQCGPEGVTFSFFWKTQGDQTRPAPYAYGGQVVSDGFKVCSSGGKGSVELYTRDNSMTWKATFNPPGPYWTHVLFTWKSKEGLKVYVNGTLSTSDPSGKVSHTYGDPHVNLVIGSEQDQTKRYENGAFDEFIIWERALTPDEIKMYFTAAIGKHALLSSTPPAMPTAHTVIPTDAYHPIITNLTEERKRFQRPGTVLRYLQNVSLRLPNKSLSEETALNLTETFLRTVGEVLLLPSWTHESEDNAMTLGLVDTIDTVMGHISSNLQSREPHVTLTGSSSTAEFTVAKVLPPALSAPHYRFPAHGHSYIEIPREALHSQAWTTIVGLLYHTMHYYLKNIHPTSTEIPEAVNCRDCLLSVASHLISLEVSPPPTLSQNLSGSPLITVHLRHKLTQKQYSDATNESNRLFLYCAFLNFSSGEGVWSSQGCALTEGNLTYSVCHCTHLTNFAILMQVVPLKLTHGHQVALSSISYVGCSLSVLCLAATLVTFAVLSSVSTIRNQRYHIHANLSFAVLVAQVLLLISFSMEPGTVPCQVLAVLLHYFFLTAFAWMLVEGLHLYSMVIKVFGSEDSKHLYYYGIGWGCPLLICIISISSSMDSYGTSDSCWLALGSGAIWAFVGPALLVIVVNIVILVAVTRVISHISTDSYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAVSDRALVFQYMFAILNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTANTKPFSSDTVNGTRPGTASTKLSPWDKSSHSAHRVDLSAV
What is the function of this protein?
Orphan receptor.  Signals via G(s)-alpha family of G-proteins.
What are the official names of this protein?
Adhesion G-protein coupled receptor D1, G-protein coupled receptor 133, G-protein coupled receptor PGR25.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: V1R54_MOUSE
Sequence: MNKMNRLSHNTEIRNAIYSGVGIGISGNSFLLLFHIFKYIRGQRSRHIDLPIGLLSLIHLVMLIAMSLVATDIFMPWGRWGDTTCKCVISLYRFCRSLSLCATSLLSILQAVTLNPRNSCLEKFKRKSPHYMLGCLLFLSVFYTFISSPLATYITAKSNLTSPSFTYITTSCSLAPMSYSFHLTVFILLTSRDVIFVGLMLLSSGYMVTFLGRHKKQSQFLHITSFSLKPSAEKRAMRTILCLMSFFVLMYTLDSIVSYIRSIDDGQIFYCVHIFTAHGYATVSPFLILSTEKYIINIFRSTFGRMVTIILLRNR
What is the function of this protein?
Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
What are the official names of this protein?
Vomeronasal type-1 receptor 54, Pheromone receptor VN7, Vomeronasal receptor 7, Vomeronasal type-1 receptor A9.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FCG3A_RABIT
Sequence: MGQPLPPVALLLLVSASSRAADVPKALVLLDPPWASVLKDDHVTLKCQGLHPAGDNTTQWLHNGSLLSSQAPAYTITAARAEDGGEYRCQTGLSSLSDPVQLHVHLGWLVLQAPRWVFQEGEPIQLRCHSWKNNKLHKVTYLQNGRGLRYFHQNSDLHIPEATRNHSGSYFCRGLIGHHNMSSETVTITVQGPANPVISSSVLPWHQIAFCLVMGLLLAADTGLYFSVQRDLRSSQRARKEHTLGWSLGSQDK
What is the function of this protein?
Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (By similarity).  Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC).  Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger.  Mediates IgG effector functions on natural killer (NK) cells.  Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity).  Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes.  Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity).  Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821).
What are the official names of this protein?
Low affinity immunoglobulin gamma Fc region receptor III-A, IgG Fc receptor III-A, FcgammaRIIIA.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RNPA_LEGPL
Sequence: MFAFKKAQRLLKKNDFDFVFESAKKITTEDFIFLFRENKLGYARLGLALSKKMIAKAHDRNRIKRLLRESFRHTNLPAVDIIILARPGLAKKTNLGINTKLNKTWEKLTSCYGK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: SNX1_MOUSE
Sequence: MASGGGGCSASERLPPPFPGMDPESEGAAGASEPEAGDSDTEGEDIFTGAAAATKPQSPKKTTSLFPIKNGSKENGIHEDQDQEPQDLFADATVELSLDSTQNNQKTMPGKTLTSHSPQEATNSPKPQPSYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPMFRSRQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQALSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTALFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDSFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKRESEARLLWANKPDKLQQAKDEITEWESRVTQYERDFERISTVVRKEVTRFEKEKSKDFKNHVMKYLETLLHSQQQLAKYWEAFLPEAKAIS
What is the function of this protein?
Involved in several stages of intracellular trafficking.  Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).  Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex.  The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling.  The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC).  Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity.  Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1).  Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi.  Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R.  Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN.  Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (By similarity).
What are the official names of this protein?
Sorting nexin-1.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans- Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles. Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner.
Protein: TWK9_CAEEL
Sequence: MKCSFHIPEKYQWASTLFVHVALIAGVAVYTVFGALSMQWLESPDRVRALLKRELKPVESLPPPPSISGLPDRITRVYLGEELAILDPGVHECLERTILTLFHDTKCDPYSFEHLNIELIDRCYAEANVPIPEGYGGQPRKKIKNKEEEKDVIDETPAEKWSIGNSVIFAFTVITTIGYGHVAPETFEGRLFLIFYGVIGVPFTLLTIADLGMFLTRFLKNLLTMARRFAHYLVKLYQKAKKQRNKSQKTSPVMPDSERSEVWNTGKEMKEMSMRTAREPGEGDEIEVIENGNDENGKEEDEEEPENNEPRKTEESIALGITFTCYLVAGAKILSVYEPEMDFFKALYFNFVTLTTIGLGDFVPKSFDYLLITLIYIGIGLALTTMAIEIAADLLKKLHYIGRKMENVGQAVVWFGGKKMTMKSLVKHLGDQFNIPEEELANFDMSAFVDNAIKVEKGEIATLRKPPTPPVVFRERAFSFSNVRNSSESALKYVDDNRFSKTTQPTIYTVIIHETTRTIDTLHNLADAIRRDPSIPRLDLDVHYLTDMSAPTSFDENYLRTYTNARRK
What is the function of this protein?
Potassium channel protein that may be component of regulatory network that controls ray development and function.
What are the official names of this protein?
TWiK family of potassium channels protein 9.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNAJ_RUEPO
Sequence: MSKRDYYDVLGVSKGASADEIKKAYRGKAKELHPDRNKDNPDAESLFKEVNEAYEVLKDAEKKAAYDRFGHAAFEGGMGGGQRPGGGFGSGDFSSAFSDVFEDLFGDFMGGQRGGGGRRAARGSDLRYNLRVTLEEAFSGLQKTINVPTAVACSSCEGTGAEGGVEPTTCPTCSGMGKVRAQQGFFTVERTCPTCSGLGQIIKNPCKSCRGQGRVEKDRALSVNIPAGVETGTRIRLAGEGEAGMRGGPPGDLYIFVEVAKHELFERDGVNLYCRVPVSMAKAALGGAIEVPTIDGGRGRVQVPAGSQSGRQMRLRSKGMPALRGGGIGDMFIELAVETPVNLTSKQKDLLREFDELSEDNNPETKSFFSSVKSFWDGMKG
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.