PharMolix/UniProtQA huggingface dataset:
Protein: MDTD_ECODH
Sequence: MTDLPDSTRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLLLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLTIAGLVAVGVVALVLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGLFGSQHVSVDSGTTQTVFMYTWLSMALIIALPAFIFARVPNDTHQNVAISRRKRSAQ
What are the official names of this protein?
Putative multidrug resistance protein MdtD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSBE_CHLRE
Sequence: MAGKPVERPFSDILTSIRYWVIHSITVPALFIAGWLFVSTGLAYDVFGTPRPNEYFTEDRQEAPLITDRFNALEQVKKLSGN
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit alpha, PSII reaction center subunit V.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single- pass membrane protein.
Protein: SYE_STRP3
Sequence: MSKPIRVRYAPSPTGLLHIGNARTALFNYLYARRHGGTFIIRIEDTDRKRHVEDGERSQLENLKWLGMDWDESPETHENYRQSERLALYQQYIDQLLAEGKAYKSYVTEEELAAERERQEAAGETPRYINEFIGMSADEKAKYIAEREAAGIVPTVRLAVNESGIYKWADMVKGDIEFEGGNIGGDWVIQKKDGYPTYNFAVVVDDHDMQISHVIRGDDHIANTPKQLMVYEALGWEAPEFGHMTLIINSETGKKLSKRDTNTLQFIEDYRKKGYMPEAVFNFIALLGWNPGGEEEIFSREQLIALFDENRLSKSPAAFDQKKMDWMSNEYLKHADFETVYALCKPFLEEAGRLTEKAEKLVELYKPQLKSADEIIPLTDLFFSDFPELTEAEKEVMAGETVSTVLQAFKAKLEAMSDEDFKPENIFPQIKAVQKETGIKGKNLFMPIRIAVSGEMHGPELPNTIYLLGRDKSIEHIKNML
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSAK_MASLA
Sequence: MLTSTLLAAATTPLQWSPTVGIIMILCNIVAIAFGKSTIQYPNAGPALPSSQFFGGFGLPALLATTAFGHILGTGVILGLHNLGRF
What are the official names of this protein?
Photosystem I reaction center subunit PsaK, Photosystem I subunit X.
What is the protein family that this protein belongs to?
Belongs to the PsaG/PsaK family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi- pass membrane protein.
Protein: SRDD_NEUCR
Sequence: MAPPNKNPNGYYVESFPAPGLRQIVRHITGLNKQGESVFLHSDHGDHHRFMVQNQAISNLLYSTQETPVDLNNNIDIQKAKEKEPPFHYKSGSIVRMIDFGPGVESPLHRAMTIDYGIIVEGVFELILDSGEKRIMRQGDVSVQRATAHKWVNVTGNGTLPGRVMWVLLDCKEVVDAKGEKVEGYLGSLQEHYEGR
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040).  The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040).  SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040).  The polyketide chain is then reductively released as an aldehyde (PubMed:30908040).  The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040).  This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040).  The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040).  This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).
What are the official names of this protein?
Cupin-domain-containing oxidoreductase srdD, Sordarial biosynthesis cluster protein srdD.
What is the protein family that this protein belongs to?
Belongs to the virC family.
Protein: LRK1_CAEEL
Sequence: MDLSSGGPSSSSDVASELDNSDAMQLVRQAVLFENVELLADLFKVNPWVWNRVDRHGRTPLMLAAHNGKLDSLRTILMLSPNSLNLVNDRGKTALHMAAESGETSIVLELVELGSDPMKSDNEGHCALELAQMAGHNEVAAKLIDAIQKESEDLNEAHTMIISACISGSADVVYEISRRFMEKKQSREILFNGRNEEDETALLIACTNGHIEIVRHLLQFEEHLLQSHVSKDTVIHAAVSSQNVEVLQLCLEKFPQLVKSTNNEGSTCLHWAARCGSSECVSTILNFPFPSEFIIEIDTVGAPAYQLALDVNEVDGECRTAMYLAVAEGHLEVVKAMTDFKCTSIDGRQRCPFQLDVYCTRGRTPFMLAAFNQNLPLMTLLLDAGADVNLPLAVLDTEYSVEEGRCIGSGALVEAVRSDGLHIVHFLLDRGALDTDNKALRLAAQGKNEKLIRVFLVRLVFADPEYKINKKNIDVGQIQVGQSLLPSSLCPSKAAQLNWNSANLEQLQSDWFVAAALHVNPRLRTTRLSLAAITRVDLSDNRLNTFPSILFQMPSLRSLNLADNSIRKIEIPTYYISSTSLEILNLRNNQLECIAIQFLSSLPQLQQLDVSKNELSQLPEYIWLCPALKELNASYNRLSTLPMVARASRGERPRLNNSNNNFNTQSPTQESNPIVVDDPPNVTSNPLRRQNVWQASINLSKVDDDSLFPDFPVTSSNTLTTINLSFNKFHTFPFCLACTCPRLLILNMSNNSMTSLPPMACVPAHLRTLDLSYNKIQESFIEASPLHVVCHAVPPTTSNGSMLPKRRNSPARQHRSRSKSAVRSQRSLSVSRHHALIDPQKEEESCVHKRHDSLEWLKTLQLAGNRLRSISVTNAASKVLLPALNVMDISDNKLLQAPPDVARLTLLSMLNLSGNTAIKELPPDYGMLSRLWSLSLKGCSLKEPLESMVNVENCKTVEIVAYLKTILEESKTYHHLRLMILGSDGVGKSVIWDALCKEAVQKRQPIHSETGVIRQAEWKFEAKRSKGDKNLGPVGFSVIDFGGQREYHSTHQYFLSKRSLNLVLWKITDGDEALAQLDTWLVNIHARAPNSTVILVGTNLDQVASNSSKFGPGYIDIMEQKVRTRYMVADADKSGLPRIVDVILINSTSRNDVKALLNTIYRTAWEVRMGKERAMEQQIPSSYIALMKVTKELGVEFRKEGQPAVMTVEAYRERVKKRMISKFGRPFRDDIEFYAACTFLHDCGELVRFEDATLRDLIFVDPLWLAEFLTSVVILRSPNLPAGLLSTDAINPHTRSFKSGALLMLKTQLLDLLHKFELALATQPRQLLIPSLLPDEYRLRSDFLASAVKIRMKMSQWNVRCPSPAGSPTKSPLRRTSPTDQNGVGSEDVMLQFTYDDDQLLRRIYALAYIPSGFWSRLVTRIVGDKNVCAAIESIFMTTSADRAKIADIATKHAKAEWVVWQTGIELHVKGHSLFTLKQFLPLAEVRDIDYSAIDMRAKDEQKRWRTWNQPSHRPIVEMVVNSLSISAASQHGRKLSMKTDVEGRSRLLAMISDLLDTLLEDWYPALGTRFVHSSEGDLLVSRYVLCPQCVRDAERNGSRSRTSSSASHRRSQDDGELPITSSSHMKGSRTTGDISKCRGGVVHCFVIEECMLAGREYNWVECPSHGGLHMRELAPDTVFADIENALTIHPDQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGFCAAPEFTHLLDVCELGEALPPTQLMAVGITDEIDDPDDFEAQLWLSGREMVVMGCTQYGFVDQKSIELPHRGKYVSKVRDSVWSCDECGQVTVYGISLHETGHLQLPSLNGTLICAPELISNDVLILISDKQIVLLKLSESNSVSHLGTIDSPYEIRTATFLGNGSTRQIWAGHSEGRISIHHIASNDSFSFSSSLYLPDDKCIVRQLVGSKDAQKVWIALEKSSKVQMVEVEKRQVTGSLDIRKVMPGSETIHTIDMEMASQNYVTCIGLLERNDGDQLYIGTSKGLLVIAHATTLQPLSACRPFEGDITSICILEEPSREEENTRGKATTLSTASSESGLGWVRERVSETVDRFRSSPATVETQGAALVVCIGRQFRSLSHRFVAEEKLADVYSIAVWRTEEWAL
What is the function of this protein?
Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi.  Role in stress response.  Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.
What are the official names of this protein?
Leucine-rich repeat serine/threonine-protein kinase 1, Leucine-rich repeats, ras-like domain, kinase protein 1, PARK8-related kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: NU6C_PHAVU
Sequence: MDLSESLHDFILVFLGSGLILGSLGVVFFTNTIFSAFSLGLVLVCVSLFYILSNSHFVAASQLLIYVGAINVLIIFAVMFMNGSEYDQNFRVWTVGDGITLMVCTSIFISQINTILDTSWHGIIWTTRPNQILEQDLISTSQQIGIHLSTDFFLPFELISIILLVALIGAIFVARQ
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic, NAD(P)H dehydrogenase subunit 6, NADH-plastoquinone oxidoreductase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: IBPB_HISS2
Sequence: MPKYKYNKINILFSCCLLVSFVVAPLVVQAQEDPLVTQAREAAKEAKPLVQELLHLKNQQQFEKVEQNFEKAQRFLEDNRPNQEQIVEQLKSAKDVQTITKITIDFGGEEIFLDFDEVTKHYLNQPLSAKTVFALTKELTQVLYNAGYVTSAIGLKSSKIKNGEVEFVVLWGKVNDILVEEQQASLFKDKAMLFVLPNLKGKVLRIYDVDQLIEILNTGNKTAKVNVIAANEKSMSNLSIERHRTSYPQVSLSLNNSGEGSNAEGRNQATLSISWSDLLGTNDRWSFSTGYRIYKDRQANRQQNYSLSYTQPFSFSTLDIKLSYSGYKKQLRGIHTHGSSGETKQASFKLSHTLLRNKDMILSLYGELEFKRRLSYFGDIRIGKYHNNKLNIGLSYVTNLGHGKLYSDLSYSNGLRWFNANHSAYNSHRDKTLRLVSGSINWQRPFVFFNRGMSYQFRLGAQYGFDSLYGENQFSIGDEYTVRGFKGGAGSGDRGFYISQTVTIPFYPQKSYLSYINPFLGIDIGKVHAKRPHHVVDTFAGFAFGVKAQIKSLALSLTYAKPINGVGTFEESNKKSVFYFTGSVSF
What is the function of this protein?
Possible member (with IbpA) of a two partner secretion pathway (TPS) in which it would mediate the secretion of protein IbpA (high molecular weight immunoglobulin-binding protein).
What are the official names of this protein?
Outer membrane transporter protein IbpB, TpsB transporter.
What is the protein family that this protein belongs to?
Belongs to the TPS (TC 1.B.20) family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: TAF5_ARATH
Sequence: MDPEQINEFVVGYLKKKGFSSAAKDLESYHHQNNNGSSFTSVDYHNDPELTKLIRSFSQQEDDPTRYREGYSKLRSWAYNSLDLYKHELLRVMYPVFIHCYMDLVGKGHTQEARAFFNSFRKDHEMVHLRDLQKLEGVLSPSHLEEMEFARSLRKSKVNIKFCQYSYELLLQYLHSTVSTLMLGIINEHINFQVYSGQPTSSSDDIEAVTIVGSFQDTANHINQKEIQWGLLEDSLEDRLEKTGGLLSDSEKGQGESKDGDADDSKKRSTEIGKQGSSLKKLKKDKAGNATAKVARLETITVSPAPRVKPELALPVMSTDVEQSILEDLRNRVQLSSVAMPSVSFYTFVNTHNGLNCSSISHDGSLVAGGFSDSSIKVWDMAKIGQAGSGALQAENDSSDQSIGPNGRRSYTLLLGHSGPVYSATFSPPGDFVLSSSADTTIRLWSTKLNANLVCYKGHNYPVWDAQFSPFGHYFASCSHDRTARIWSMDRIQPLRIMAGHLSDVDCVQWHPNCNYIATGSSDKTVRLWDVQTGECVRIFIGHRSMVLSLAMSPDGRYMASGDEDGTIMMWDLSTARCITPLMGHNSCVWSLSYSGEGSLLASGSADCTVKLWDVTSSTKLTKAEEKNGNSNRLRSLRTFPTKSTPVHALRFSRRNLLFAAGAISKPAN
What is the function of this protein?
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 5, TBP-associated factor 5, AtTAF5.
What is the protein family that this protein belongs to?
Belongs to the TAF5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: METK2_ACTCC
Sequence: MESFLFTSESVNEGHPDKLCDQVSDAILDACLEQDPESKVACETCTKTNMVMVFGEITTKATVNYEKIVRDTCRGIGFTSPDVGLDADHCKVLVNIEQQSPDIAQGVHGHLSKKPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTEVRKNNTCPWLRPDGKTQVTVEYRNEGGAMVPVRVHTVLISTQHDETVTNEQIAKDLKEHVIKPVIPAQYMDDDTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYVVRQAAKSVVASGLARRCIVQVSYAIGVPEPLSVFVDTYKTGKIPDKDILALIKKNFDFRPGMIAINLDLKRGGNFRYQKTAAYGHFGRDDADFTWETVKILKPKA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.  The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
What are the official names of this protein?
S-adenosylmethionine synthase 2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_GLOVI
Sequence: MLRFLTAGESHGPGLTIIVEGIPADLPLLAEDIDRDLARRQVGFGRGGRMSIETDRVTFRGGVRLGRTIGSPIAMTLENRDFKNWEVPMSVSPVDLDDEAVRAQLEAKRITRLRPGHADYPGAVKYGLADVRNILERSSARETASRVAAGAIAKQLLRQFNVHVHSHVVEIGGVGAGESVRPALPTFEEWKDLFERVDQNDLRCHPDLYERLRSRVVEAAKGGYTLGGAVELAAYGEIPVGLGSHVHYDRRIDGLLAGAAMSVHTVKAVEVGIGTAAARETGADVQDEFINAAGEIARTSNHAGGIEGGMTNGQPVLLRAYLKPLPTMRKALRSIDLVSREPFEAHYERSDTCAVPAGGVVCEAMMAIVLAQELQRKLGGDSLGEMLRHAGRTHA
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: QUEA_PARL1
Sequence: MRVSDFDFDLPEELIALRPARPRDSARMLVIGPAENALADKSVSDLPSHLREGDILVFNDTKVIPARLFGTRRRGEASARIEVMLHKRESADEWRAFLRPAKKLNLSETIDFPGGLSAAVEEKGEGGEAGLRFSLSGPALDAAIAAAGEMPLPPYIARKRAADDEDVADYQTLHADEPGAVAAPTAGLHFTPALMAAIEARGVSTVRLTLHVGAGTFLPVTAEDTDTHKMHAERGEITEAEAAAINEARAKGGRIVAVGTTSLRLLESAVDEAGTVHPFRGETDIFITPGYRFRAVDVLMTNFHLPRSTLFMLVSALRSTEEMKRAYAHAVAEKYRFYSYGDACLIYGAS
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_EXIS2
Sequence: MAKKSMIAREVKRQALVERYAEQRAELKAQGDYIGLSKLPRNSSAVRLHNRCSITGRPHGYIGKFGISRIKFRDLAHKGQIPGVKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: SECB_DESPS
Sequence: MAETNEKQAAHPEFRMQKMYTKDLSFESPSAPAVFLDGGSEPKVELNLQLNNKKVDDDHWEVSLEINAKVTADDGAKTLFILELEHAAIFWVRNIPEEHLAMVLAVDCPTLLFPFTRQIASQVSVDGGFAPFLMEPVNFMALFQGAKKQEQEQTAN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR8_PYRAB
Sequence: MAVHPIDYRYGSEEMRRVWEEENKLQKLLDVEAALARAHAKLGNIPEESARVISERANTKWVKLERVKEIEAEIHHDIMAVVKALSEVCGEHGKYVHLGATSNDIIDTANALLIKESLAIVEKDLKELRSILKELAKKHIDTVCIGRTHGQHAVPTTYGMKFALWLDEIQRHIERLQQLKDRVLVGKMRGAVGTAASFGDKAFEIEKLVMEDLGLKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVIPALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTENDLEGLKPENYIGKAREIVENVVNYVEEMERRGL
What is the function of this protein?
Catalyzes two reactions in de novo purine nucleotide biosynthesis.  Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
What are the official names of this protein?
Adenylosuccinate lyase, ASL, Adenylosuccinase, ASase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Protein: SYFA_ALTMD
Sequence: MELDAIINQAQSQIDAAQDAATLDQVRVEFMGKKGKLTDLLKGLGKLSNEERPAAGQKINQAKQVIQQAISAKGEFLRTEELNKKLAEEAVDVTLPGRTEKPGNLHPVSRTIARIESFFGELGFSVKTGPEIEDGFHNFDALNIPANHPARADHDTFYFNPDMMLRTQTSGVQIRTMEAEKPPLRIISPGRVYRNDYDQTHTPMFHQVEGLMVDKNVSFTDLKGILHDFLHHFFEESLEIRFRPSYFPFTEPSAEVDVMGKNGQWLEVLGCGMVHPNVLKAVGIDPEEYTGFAFGMGVERLTMLRYGVNDLRAFFENDLRFLKQFN
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TF2H4_DICDI
Sequence: MTLSKVFQYLASLDSKDLEELYKDPWTCQAILRSLPPRSKQYILKMLLVDTYPLSLAKDWSTQASIQQHKESLKKLFDLKIIFLDKINKPIQPQQQQSSQQSSSQQQQQQQQQQQQTEQTIRLNPLFQDNIKRSLVQVNQVIFSNNSSIKDNHKPPSIDDLDSYSKSQWEKVLYFLSDDTVQPSKLISELLLSSNLTKQEGDGLSITSEGFKFLLKDVYTQIWTLLIVYLDDLEKKKGKGSGSRNDLLSFLFRLSFLNLGRGYLVSELSEQQKEYLFALKQFGLIYMRTDSSILFYPTRLIISLTTGKTLSLIQSISSERTQTQKEQGYIVLETNYRLYAYTSSSLQISLLSLFVKMLYRLPNLAVGIITRESIRTALIHGITADQIIDFVRHNSHPNAANSGQPIPDVVAEQILLWEAERNRITYTKSVLYNSFPTNDCYIATLKFAKEQDYYIWSHDPLKTLVVKEEGNDPIRNFIKKNFA
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription factor IIH subunit 4, TFIIH basal transcription factor complex subunit 4.
What is the protein family that this protein belongs to?
Belongs to the TFB2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASSY_DESPS
Sequence: MSVDKIVLAYSGGLDTSVILKWLANEYECPVVAYSANIGQIEDWDAVKEKGMATGADKVIVSDLQKEFVEDYIFPAFRASAIYEGTYLLGTSLARPLISKEQVRIAHAEGANAVSHGATGKGNDQVRFELGYIGLDPSLQIIAPWRTWDLNSRTRLEEYAKQHNIPVPTTKKNPYSSDENLLHISFEGGILESPWNEPDPDMFKLTVSPEMAPDKPTYLEITFQNGDPIALDGVAMEPLELFRALNKVAGENAVGRLDLVENRFVGMKSRGVYETPGGTLLYHAHRDLETICLDREVMKIRDSLVPRYAELIYNGFWFSPERELLQMTMDTAQKTVSGVVRMKLYKGNCFSVGRKSDQSLYKEDFATFEADDVYDQGDATGFIRLNGLRLKINALQGK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_RICRO
Sequence: MNATILVKIITPLSIALEKQAKIVTMSGEEGMFGVLPSHVPMIVSLKAGLVQVYIDDMHKSENTYLISGGVTEVTANYINIATETAINVTNLSEAEIATKLLDLQKTLSDQH
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RNP2_HALMA
Sequence: MKHLPKHLRPRWRYLAVGIETWPNASFGRRAFQREVWYAAQNLLGDTGSAETDMTVLQFHDYDGTAEAIVRTRRGQTNPARAALTCLDSVDDDDVRVRVRGISGTVRACEEKYIRGPPEFTEQRHVVFENADRSATVRPPRYDVETASDGAFVGATALDFR
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 2, RNase P component 2, Pop5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UB4AB_SALSA
Sequence: MILTIKPLQGKECNVQVTEDEKVSMVKELVSERLNIPANQQRLLYKGKALADEHRLSDYSIGPEAKLNLVVRPAGERSGMASSSSAVSGVWQTLSTVLAKHFSPADAAKVQEQLVKDYERSLRQLSLDDIERLAGRLLHPDSEGMDTSYMD
What is the function of this protein?
Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane.  TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region (By similarity).
What are the official names of this protein?
Ubiquitin-like protein 4A-B.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: SYD_STRZT
Sequence: MKRSMYAGRVREEHIGQEITLKGWVGRRRDLGGLIFIDLRDREGIMQLVINPEKVSAEVMATAESLRSEFVIEVTGQVAAREQANDKLPTGAVELNVTALIVLNTAKTTPFEIKDGIEANDDTRLRYRYLDLRRPEMLENLKLRAKVTHSIRNYLDELEFIDVETPFLSKSTPEGARDYLVPSRVNKGHFYALPQSPQITKQLLMNAGFDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLTEQEIQDITEGLIARVMKETKGIEVTLPFPRVKYDDAMALYGSDKPDTRFDMLLQDLTEVVKGVDFKVFSEAPAVKAIVVKGAADNYSRKDIDKMTEVAKQYGAKGLAWVKVVDGELNGPVAKFLTGIQEELTTALALEDKDLVLFVADTLEVANATLGALRGRIAKELGLIDNDKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPQEETAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKDLQERMFKALGFSAEEANDQFGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGEENIREVIAFPKNNKATDPMTQAPSTVALKQLEELSLQVEEDETSKTN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC_CUPMC
Sequence: MSPTPIKHYLQFSDLSADEYEYLLDRARILKAKFKNYETWHPLHDRTLAMIFEKNSTRTRLSFEAGIHQLGGHAVFLNTRDSQLGRGEPIEDAAQVISRMVDIIMIRTFGQEIIDRFAKHSRVPVINGLTNEYHPCQVLADVFTYIEQRGTIAGKTVAWIGDANNMAYTWIQAAERLDFTFHFSAPPGYQLDPAMVPDWAASRVKVFDNPLDACQGAHLVTTDVWTSMGFEAENDARKRAFKDWMVTTAMMDRAADDALFMHCLPAHRGEEVEAAVIDGPRSVVWEEAENRLHVQKALMEYLLCGRY
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.