PharMolix/UniProtQA huggingface dataset:
Protein: CHR19_ARATH
Sequence: MKRDFDEISEEEWSQHSFNASRVLKRPRTPKKTRAATNPTPSIESFAFRRPSTAMTIESNSSDGDCVEIEDLGDSDSDVKIVNGEDLLLEDEEEVEETKVVMRAARVGRRFVIEDEEASDDDDDEAESSASEDEFGGGGGGSGGRRGEDEDVVGKALQKCAKISADLRKELYGTSSGVTDRYSEVETSTVRIVTQNDIDDACKAEDSDFQPILKPYQLVGVNFLLLLYKKGIEGAILADEMGLGKTIQAITYLTLLSRLNNDPGPHLVVCPASVLENWERELRKWCPSFTVLQYHGAARAAYSRELNSLSKAGKPPPFNVLLVCYSLFERHSEQQKDDRKVLKRWRWSCVLMDEAHALKDKNSYRWKNLMSVARNANQRLMLTGTPLQNDLHELWSLLEFMLPDIFTTENVDLKKLLNAEDTELITRMKSILGPFILRRLKSDVMQQLVPKIQRVEYVLMERKQEDAYKEAIEEYRAASQARLVKLSSKSLNSLAKALPKRQISNYFTQFRKIANHPLLIRRIYSDEDVIRIARKLHPIGAFGFECSLDRVIEEVKGFNDFRIHQLLFQYGVNDTKGTLSDKHVMLSAKCRTLAELLPSMKKSGHRVLIFSQWTSMLDILEWTLDVIGVTYRRLDGSTQVTDRQTIVDTFNNDKSIFACLLSTRAGGQGLNLTGADTVIIHDMDFNPQIDRQAEDRCHRIGQTKPVTIFRLVTKSTVDENIYEIAKRKLVLDAAVLESGVHVDDNGDTPEKTMGEILASLLMG
What is the function of this protein?
DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization.  Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity).  Probable chromatin remodeling factor.  Probable helicase-like transcription factor involved in transcriptional gene silencing.  Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci.  May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin (PubMed:25420628).
What are the official names of this protein?
Protein CHROMATIN REMODELING 19, AtCHR19, AtRAD54-like protein.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYD_STRP4
Sequence: MKRSMYAGRVREEHIGQEITLKGWVGRRRDLGGLIFIDLRDREGIMQLVINPEKVSAEVMATAESLRSEFVIEVTGQVAAREQANDKLPTGAVELNVTALIVLNTAKTTPFEIKDGIEANDDTRLRYRYLDLRRPEMLENLKLRAKVTHSIRNYLDELEFIDVETPFLSKSTPEGARDYLVPSRVNKGHFYALPQSPQITKQLLMNAGFDRYYQIVKCFRDEDLRGDRQPEFTQVDLETSFLTEQEIQDITEGLIARVMKETKGIEVTLPFPRMKYDDAMALYGSDKPDTRFDMLLQDLTEVVKGVDFKVFSEALAVKAIVVKGAADNYSRKDIDKMTEVAKQYGAKGLAWVKVVDGELNGPVAKFLTGIQEELTTALALEDKDLVLFVADTLEVANATLGALRGRIAKELGLIDNDKFNFLWVVDWPMFEWSEEEGRYMSAHHPFTLPQEETAHELEGDLAKVRAIAYDIVLNGYELGGGSLRINQKDLQERMFKALGFSAEEANDQFGFLLEAMDYGFPPHGGLAIGLDRFVMLLAGEENIREVIAFPKNNKATDPMTQAPSTVALKQLEELSLQVEEDETNKTN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1078_STAES
Sequence: MNELEFVTLHRRHLHQYPELSLHEFETTSYITSFLEDLGVPYDRPLKTGVIAYLEGNSHHTIAFRADIDALPIYEENDIDFKSKNDNVMHACGHDGHTTALMLFVKRCKALYDKSELPHNVVFIFQPAEETGGGANRLIKAGAFDKYPIEAVFGFHVNPFEKEGKIVIRDEEITASATEYRFFLKGLSSHVADKEQGHSCGEGLQHVLSQIGQIQQFHLNGLKRNIIHMGHFEAGEAINTVPSHGYLEGTIRTYDTEDLAIVKHQMHKIAKSVQLLFNVECEVKFEEGYPPTMNHPQLRQAVENAIKGANLEIVEKKLPFLFGEDFSFYGQQLAPSYFVFVGTQNNEKGFVTGLHTAHLNFDEKILIDVVNYYEHLLRNYKEV
What are the official names of this protein?
Uncharacterized hydrolase SE_1078.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20 family.
Protein: RS15_HELLU
Sequence: MAETAEDLAEKKKKRTFRKFTYRGVDLDQLLDMNMDQ
What are the official names of this protein?
40S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: GLO2_AERS4
Sequence: MYTVITVPAFTDNYIWLIRHENHCLVVDPGDAGPVLDRLAALDLQLDAILLTHHHQDHVGGVTALLKHFPHARLYGPKHDPMPDHHGQWLDDGDQINWHGLSLDVIHVPGHTHGHIAYHGHGMLFCGDTLFSGGCGRLFEGTPAQMHDSLQRLAALPDDTLIYCAHEYTLSNLRFAYAVEPDNKAIQQRIGMISKLRQQGLPSLPSRLGDERDFNVFLRCEQDSVKFSAEKYALKCLENPEDTFAVLRSWKDVF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: EST1_MACFA
Sequence: MWLRALVLATLAAFTAWGHPSSPPVVDTVHGKVLGKFVSLEGFTQPVAVFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCSQDAVAGQVLSELFTNRKENTPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLVVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQLAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTAVLVKKGDVKPLAEQIAIAAGCQTTTSAVMVHCLRQKTEEELLETTLKMKFFSLDLHGDPRESHPFLGTVIDGLLLPKTPEELQAERKFNTVPYMVGFNKQEFGWIIPMLMGYPLSEGKLDQKTAMSLLWKSYPLVYIAKELIPEATEKYLGGTDDPVKKKDRFLDLLADVMFSVPSVIVARHHRDAGVPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPRWPEYNQEEGYLQIGANTQAAQKLKDKEVAFWTTLFAKKAVEKPPQTEHIEL
What is the function of this protein?
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.  Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester.  Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.  Converts monoacylglycerides to free fatty acids and glycerol.  Hydrolyzes of 2-arachidonoylglycerol and prostaglandins.  Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process.  First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile.
What are the official names of this protein?
Liver carboxylesterase 1, Cholesteryl ester hydrolase, CEH.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Cytoplasm. Lipid droplet. Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets.
Protein: AB17B_XENLA
Sequence: MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLICDESGSRWTLHLSERADWQYSSREKDAIECFMTRTSRGNRIACMFVRCCPSAKYTLLFSHGNAVDLGQMSSFYIGLGSRINCNIFSYDYSGYGSSSGKPSEKNLYADIDAAWIALRTRYGIRPEHVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLERLKQFVAQELVNL
What is the function of this protein?
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins.  Has depalmitoylating activity towards nras.
What are the official names of this protein?
Alpha/beta hydrolase domain-containing protein 17B, Abhydrolase domain-containing protein 17B.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. ABHD17 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cell projection, dendritic spine. Postsynaptic density membrane.
Protein: KHSE_METVS
Sequence: MKKVKVCAPGTSANLGPGYDIFGIALSKPYDIVTIEKVDEFGIKITLEGEKAEEIPTNVEENTAGVVAKKMIEDFKIESGIHIHIVKGIKPGSGLGSSSASCAGVAFGLNELFELKLSKLDLVKYASLGEAVAAGAPHADNVAPAIFGGFTLTTNYEPLEVLHIPVEIDVIVALPNIQVSTKSAREILPKEVPMKSMVNNVGKAAGMIYALYNNDLDLFGQYMSKDAVVEPCRAQLITGYLEIKEKLKDLVYGVTISGSGPAIIAIPKKEHVIDIKNIFKEVYNCPVYYTRVGLGCYIEEIE
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_PELTS
Sequence: MLERLQEICEEARAALNGACSLEELNEIRIRYLGKKGELTRVLRSMGSLSAEERPRIGQAANEIRDFIEKELAARTAALKEMVKEQKLRGDKIDVTLPGMPLPGGGKHPLTLVLEEIQRIFLGLGYSIVEGPEVETDYYNFEALNLPKDHPARDMQDTFFIGGEILLRTHTSPVQVRTMEKTAPGLPVKIIVPGKVYRRDDDATHSPMFHQVEGLAVDRRITFSDLKGTLDLFAREMFGPQTRTRFRPSYFPFTEPSAEVDISCVMCGGRGCRVCSQTGWLEILGSGMVHPRVLEVSGYNSEEVTGFAFGMGVERIAMLKYGIDDMRLLFENDLRFLQQFRS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LT_POVMK
Sequence: MDHQLTREESQRLMHLLKLPMEQYGNFPLMRKAFLRACKIVHPDKGGSDELSQELISLYRRLEESLPCLSTQDFIETDILQIPSYGTPEWDEWWKEFNKDFDLFCNEAFDRSDDEQEPQPDDSAPIILSPTYPARSQATPPKKKAKMDSPNDMPADLMEYLSCAILSNKTLPCFLIYTTLEKVELLYNKLSEEVLSPRFNQVDHKYGRKYVPIFIITGTKHRVSAVFNYCATYCSVSFIVVKGVIKEYPLYCHLCVEPYSVLQESIEELNSEFFDAPEDAAKNVNWVAISEYALKINCDDIYLLMGLYKEFQSPVPNCSKCENRMLTNHFKFHKEHHENAFYLQLVENQKTICQQAVDGVIATKTVDMAQMTRNEQLAARFDKLFERLEVILSAQSSYTISMFMAGIVWFENLFPGQSFKDLLLELLECMVSNIPKRRYWLFTGPVNTGKTTLAAAVLDLGGTIYISDCYLIELEVANSQIHGCVEVLAEKVKIRLPPGQGINNLDNLRDHLDGAVKVNLEKKHLNKKTQIFPPGIVTSNEYFIPFTLRVRFCKKLVFKFSKYQYLSLKKTECLGRYRILQNGCTLLLLLIYHCDLDDFAESIQGKVRAWKERVNSEISVSTYLEMRQCCLEGRYSVCTKYSNANTAQ
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription.
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.
Protein: METK_MYCSK
Sequence: MSKGRLFTSESVTEGHPDKICDAISDSVLDSLLAQDPRSRVAVETLVTTGQVHVVGEVTTSAKEAFADITNTVRHRILEVGYDSSDKGFDGTTCGVNIGIGAQSPDIAQGVDTAHETRVEGAGDPLDLQGAGDQGLMFGYAIKDTPELMPLPIALAHRLARRLTEVRKNGVLDYLRPDGKTQVTVQYDGVTPVRLDTVVLSTQHAEGIDLEGTLTPDIREKVVNTVLSDLNHDSMDTSDFRLLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLADRVEVQVAYAIGKAAPVGLFVETFGTETVDPAKIEKAITEVFDLRPGAIVRDLDLLRPIYAPTAAYGHFGRTDIDLPWERTDKADALKTAV
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRG1B_DANRE
Sequence: MGPNRIYISVGYSTFGMLVGFSAFIVWNVVYKQPWTAAMGGLSGVLALWALVTHIMYIQDYWRTWLKGLKFFMFVSSVFSLLAVAAFATFITLSVIEKQSLSDPKSFYLSAVWSFMTLKWAFLLGLYSYRYRQEFADISILSDF
What is the function of this protein?
Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
What are the official names of this protein?
Heme transporter hrg1-B, Heme-responsive gene 1 protein homolog B, HRG-1B, Solute carrier family 48 member 1-A.
What is the protein family that this protein belongs to?
Belongs to the HRG family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein.
Protein: PAND_MYCVP
Sequence: MFRTMLKSKIHRATVTQADLHYVGSVTVDADLMDAADLIEGEQVTIVDIENGARLVTYVITGERGSGVIGINGAAAHLVHPGDLVILIAYGTMEDAEARAYRPRVVFVDADNRPIDLGVDPAYVPPDAGELLSPR
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQNX_ACIC1
Sequence: MTPHDPVSVEAVPKIELHVHLEGTVEPATVLDIAARNGLALPVSTVDELSALYRVTTFSDFLRLWILTTNVLRKAEDFSQVVVDYARRAKRHGAVYIEGIFSPVERVMRGVGWAEIFDGYCEGAERAYAEHGVVVRLTPEAYRGADPELVAEMVRYAGRYRDRGVVGVGIGGDERARPTRHYAAAFAPAVDLGLGVVPHAGEFPLFPDGASGAATLRETIEALNPVRIRHGIAAAADPALVAVIRERGIVLDVCPTSNLRTGAIRDLADHPLPRLAAAGIPCTVGTDDPAVFDTDLSREFTIAARLGVEPRLLYDAGITGALCDDDVKSHLRQIGAATTWPTTTATWSTTAAGESL
What is the function of this protein?
Catalyzes the deamination of aminodeoxyfutalosine (AFL) into futalosine (FL), a step in the biosynthesis of menaquinone (MK, vitamin K2).  Is very poorly efficient on 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide (NECA), adenosine, 5'-methylthioadenosine, 5'-deoxyadenosine, 2'-deoxyadenosine, and AMP as substrate.
What are the official names of this protein?
Aminodeoxyfutalosine deaminase, AFL deaminase, Aminofutalosine deaminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Protein: L1CAM_HUMAN
Sequence: MVVALRYVWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLPPAGFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDETFGEYRSLESDNEEKAFGSSQPSLNGDIKPLGSDDSLADYGGSVDVQFNEDGSFIGQYSGKKEKEAAGGNDSSGATSPINPAVALE
What is the function of this protein?
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors.  During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis.  In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
What are the official names of this protein?
Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone. Cell projection, axon. Cell projection, dendrite. Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658).
Protein: NRDR_LEIXX
Sequence: MFCPFCRHPDSRVIDSRTSDDGLSIRRRRQCPECGRRFSTTETASLSVIKRSGVVEPFSREKIVLGVRKACQGRPVTDSDLAVLAQKVEETIRSTGASQIEANDIGLAILPELRELDEVAYLRFASVYQAFDSLEDFESAIQQLRVEHRGEPADVQV
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: THIM_CERS5
Sequence: MDRCGAYLDTMRSTAPLVQCITNFVAMNVMANVLLAAGASPAMVHDAEESGEFAAIAQVLTINLGTPSPRWVEGMEAAARGAVAAGRPWVLDPVAVGATAFRRGLGARLLALKPTVIRGNASEILALAGAEARGKGADSADTVAAAEAAAQRLAEGSGAVVAVTGPVDFVTDGRRGIRCGNGHALMPKVTALGCSLTGIVGAFAAGQPAFEATAAGLAFFGLAGEEAARRAAGPGSFQVAFLDALHAMTPDDLDRGAKLEAA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: Y95_ADE02
Sequence: MVKMRLSSGNSSATCTTFIPEGPGRLSGSMGSAPAAAAAWLPPAVAPPSVLLPGGRKTTVAGDSCVSPPLSTDAWPENPAGTPRSDGFLRSIYPL
What are the official names of this protein?
Uncharacterized protein E-95.
Protein: EFTS_BAUCH
Sequence: MVAITTTLVKQLRDRTNAGLMKCKKALIEANGDIELAIDNLRKSGQITAANKSSRITAQGIILTKINHNSQYGVIIELNCETDFVAKDKIFKNFGEDIITTALNQKISSLEEIKSLFEEKRITLVDTVGENINIRRINTLEGNLIVSYLHDTRIGVLLSANNISQNLYLGKQIAMHIAAMKPKYIQVNDIPSYIISREHKIQLNIAMQSNKPQKVIQQIVEGRMREFTRDISLLDQNFIIDPSQKVGQILEHYNIIVKNFIRFEVGEWIEQEEHYKANES
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBF1_CANAL
Sequence: MSDQLEKDIEESIANLDYQQNQEHHETEQDKDKEHQDVEKQSSEEETKGIEHVTDSNTDVIGVTKSQDTEEVIENSPVDPQLKEQQESTTKMSLSERDLVDEIDELFTNSTKTVTENNQPSETNKRAYESVETPQELTPNDKRQKLDANTETSVPTELESVNNHNEQSQPIEPTQERQPSTTETTYSISVPVSTANEVERASSSINEQEDLEMIAKQYQQATNLEIERAMEGHGDGGQHFSTQENGQPSGSSLISSIVPSDSELLNTNQAYAAYTSLSSQLEQHTSASAMLSSATLSALPLSIIAPVYLPPRIQLLINTLPTLDNLATQLLRTVATSPYQKIIDLASNPDTSAGATYRDLTSLFEFTKRLYSEDDPFLTVEHIAPGMWKEGEETPSIFKPKQQSIESTLRKVNLATFLAATLGTMEIGFFYLNESFLDVFCPSNNLDPSNALSNLGGYQNGLQSTDSPVGARVGKLLKPQATLYLDLKTQAYISAIEAGERSKEEILEDILPDDLHVYLMSRRNAKLLSPTETDFVWRCKQRKELLLNYTEETPLSEQYDWFTFLRDLFDYVSKNIAYLIWGKMGKTMKNRREDTPHTQELLDNTTGSTQMPNQLSSSSGQASSTPSVVDPNKMLVSEMREANIAVPKPSQRRAWSREEEKALRHALELKGPHWATILELFGQGGKISEALKNRTQVQLKDKARNWKKFFLRSGLEIPSYLRGVTGGVDDGKRKKDNVTKKTAAAPVPNMSEQLQQQQQRQQEKQEKQQQEEQQAQQSEQQQEPQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQREETQQTEQEQPDQPQEEQQQEKEQPDQQQQEKEQPDQQQPDQQHPDRQQQEQIQQPESSDK
What is the function of this protein?
Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length.  Involved in the regulation of gene expression.  Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci.  Recruits FHL1 and IFH1 to promoters.
What are the official names of this protein?
Transcription factor TBF1.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: RPIA_LEGPC
Sequence: MSELKIKAAKAAIAYIEDDMVIGVGTGSTVNFFIKELAAIKHKIEACVASSKATEALLRAEGIPVIDLNSVQDLPIYVDGADEVNERGEMIKGGGGALTREKIVANVATQFICIVDESKVVKRLGEFPVAVEVIPMARSFVARQIVKLGGDPEYREGFVTDNGNIILDVFNLNFSTPMALEDSLNVIPGVVENGVFAKRLADKVLVASASGVNNLK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: CYSJ_VIBVY
Sequence: MSSQKKVSSGNTTPSGLAGLASPLNDQQINLLQQISDLSPQQLAWVSGYFWGLSQSAAPSAVTPIAQAVSAVAAKPAGKLTIIFASQTGNAKGVAEALEQEAKAEGIAVQLFDASDYKGKNLANETHVIIVASTNGEGEAPDNAIELHEFLQSKKAPKLPNLQYGVIGLGDSSYEFFCQTGKDFDSYLAKLGATPFIERVDCDVDYDASAAQWRKQALEKVKDALSAGVEADVVQLPVAQLAAGHALYTKQKPYAATLLTSQKITGRDSGKDVRHVEIDLAGSGITYQPGDALGVWFENSGELANQVLAKVGLSGVESVDVDGESLSIHSALVSKFEITSSNPQQVEKFAQLSGSKKLLKLVEEKDKLREYAGNTQLVDLLAEKQTKLTAEELVGLLRRLTPRLYSIASSQTEVDEEVHLTVGLVEYDVKGEKRFGGASGYLAQRLEEGEQVKVFVENNNNFKLPADDNVPVIMVGPGTGIAPFRSFIQERDNRGAEGKNWLFFGDRTFTQDFLYQVEWQKYLKSGLLTKLDVAFSRDQAEKVYVQQRILENAAQVWQWIQEGAYLYVCGDANRMAKDVHQAFVAVAEQEGKMSRGDAEEFINDLRKAKRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: CDD_ECODH
Sequence: MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLAAACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLPDAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHSIDRVLLA
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.