Protein: VGFR2_COTJA
Sequence: MELGPLRVLTVLLCLAPVFAGLFISMDQPTLSIQKSVLTITTNDTLNITCSGQRAVYWSWPNNQSSVEKRLAVTGCSEGPFCKTLTLLRVIGNDTGDYRCLYGDSQAATTIYVYVQDYRSPFVTSVGDQLGIVYITKNKTVVVPCLGTVSNLNVSLHAKYPEKVFVPDGKSISWDNKKGFTIPSHLINYAGMVFCEAKIDNESYQSVIYIVAVVGYRIYDLTMNPHYQVELAVGEKLVLNCTVRTELNVGIDFRWDYPSIKERRATIRDLKTTAGEIKTFVSTLTIESVNLSDKGRYTCAASSGRMNMKNSSYFIIHESPFIHLEKMENVVEMKLGDTVSIPVKFKGYPPPEAKWYKNGKVINANHTVKLGYALVITEATEKDAGNYTVVLTNPTNKMQKRHTFTLLVNVPPQIGENALMAPVDSYKYGSTQALTCTIYAVPPPAAVLWYWQLEEECTFSPQKVRLGANPYACRKWKVISERKGGNQVEIKQRVVTIAGKTKTVSTLVIQAANVSALYRCMATNRAGSSERVISFHVTRGLEINLQPRSQLTEKDNTSLQCTADKFTFEKLSWYKLSTHVSQTPFGGLPMPVCKNLDALQKLNATVSNVNGENVTLELILRNISLQDGGDYVCIAQDKKAKTQHCLVKHLTVQEPLHPRLVGNLENQTTNIGETIEVLCTVNGVPPPNITWFKNSETLFEDSGIVLKDGNKTLTIRRVRKEDGGLYTCLACNILGCKKAEAFFSVQGAEEKTNLELIILVGTAVIAMFFWLLLVIILRTVKRANGGDMKTGYLSIIMDPDEVPIDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEYCKFGNLSAYLRSKRSEFIPYKMKSARFRQGKENYTGDISTDLKQRLDSITSSQSSTSSGFVEERSLSDVEEEDAGSEDLCKNPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSDNNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGDPKQRPTFSELVEHLGNLLQANVRQDGKDYVVLPLSVSLNMEEDSGLSLPTSPASCKEEEEVCDPKFHYDNTAGISQYRQGSKRKSRPVSVKTFEDIPLVTTVKVVQEENQTDSGMVLASEELKTLEEQDKQVKIPFSTLAPSKSNESVMSEASNQTSGYQSGYHSDDMDNMVCSSEDTELLCAQEASPTLPRCAWPGIYSPAPVASLPL
What is the function of this protein?
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and/or VEGFD and plays an essential role in the regulation of angiogenesis and vascular development.  Promotes proliferation, survival, migration and differentiation of endothelial cells.  Promotes reorganization of the actin cytoskeleton.  Binding of vascular growth factors leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C.  Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1.  Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells (By similarity).
What are the official names of this protein?
Vascular endothelial growth factor receptor 2, VEGFR-2, Endothelial kinase receptor EK1, Quek 1, Quek1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Early endosome. Cell junction. Endoplasmic reticulum. Note=Detected on caveolae- enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. Localized with RAP1A at cell-cell junctions (By similarity).