PharMolix/UniProtQA huggingface dataset:
Protein: EX7S_JANMA
Sequence: MSKKSTSAALPSSFEEAMAELEQLVARMEAGELPLEASVAAYKRGSELVKYCAAQLEKVDNQVKVLEGDMLKPFNADRAIEADE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METE_BURP6
Sequence: MTTAHILGFPRIGAQRELKFALERYWRDGASADAERALVDTGRALRAEHWRIERDAGLDCVTVGDFAWYDHVLTTLAHVGGLPRRFGFDAHALTLADYFAAARGNAAQPAMEMTKWFDTNYHYLVPEYSPATTFGPGVEWLFDEVREARALGHRAKAALVGPLTLLWLGKARDGLVERLALLPRLVPAYRALLARLREAGVDWVQIDEPIFSLDLPDAWRDAARPTYEALAPGAPKLLVATYFDDASEHAALLKALPVAGLHIDLVRADAQLDAFVADYPADKVLSCGIVDGRNVWRNDLDRSLARLAPVRDALGERLWVATSCSLLHVPVDLAHEPRLDEELKTWLAFAAQKTREVAALRDALVKGRAAVAAEFDDAAAAAAARRTSARIHNPLVKRRVAALTDADARRASTYSVRAAAQRARFGLPLLPTTTIGSFPQTPEIRRARAAFKQGVLDHLGYLEAMREQVRIAIDKQLAYGLDVLVHGEAERNDMVEYFGELLWGFAITSNGWVQSYGSRCVKPPLVYGDVYLPEPMTVGWASYAQSLSAKPVKGMLTGPVTMLQWSFVRDDQPRATTALQIALALRQETLDLEKAGIGMIQIDEPALREGLPLKARERAAYLDWAVRAFGIAASGVADDTQIHTHMCYSEFGDILPSIAALDADVISIETTRSNMELLDAFETFDYPNEIGPGVYDIHSPRVPDADEIERLILLALERIPAQRLWVNPDCGLKTREWRQVDAALAAMVDAAKRVRQKVEEAVPA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: ATP6_HELPS
Sequence: MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFLISLGASRKMQMVPMGLQNVYESIISAILSVAKDIIGEELARKYFPLAGTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYYHFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRIVSLSFRLFGNIKGDDMFLLIMLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYR_ALIF1
Sequence: MNIQSLINDKVSQALEAAGAPAGSPAAVRQSAKAQFGDYQANGVMGVAKRLGTNPREFAQKVLDVLDLDGIASKTEIAGPGFINIFLSEEFLAKQAEAALADERLGVAKEEQQNIVADYSAPNVAKEMHVGHLRSTIIGDAVVRTLEFLGHNVTRANHIGDWGTQFGMLIANLERIQKEKGEVSMELSDLEGFYRESKKLYDEDEEFAVTARGYVVKLQSGDEFCAEMWKKLVDVTMVQNQRNYDRLNVSLTRDNVMGESMYNSMLAPIVADLQKQGLAVESEGAQVVFLDEYKNKDGEPMGVIVQKRDGGFLYTTTDIACAKYRYEELNADRVLYFIDSRQHQHLMQAWTIVRKAGYVPESVSLEHHAFGMMLGKDGRPFKTRAGGTVRLADLLDEAEERATKLIEEKNKDLSAEEKAKIATTVAMAAVKYSDLSKHRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVASIFSKAGLSMDELTGEVKITDEKEKALVAKLMQFEEAVQAVASEGQPHLMCAYLFELAGQFSSFYEACPILNNEDDAVKQSRLKLAALTAKTIKQGLELLGIETLERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISZ_METCA
Sequence: MFPFSYPADDRWLLPEGIEELLPEEAERLELLRRRVLDRFAAWGYRLVMPPLIEFIDSLLTGAGHDLDIQTFKLIDQASGRLLGIRADMTPQVARIDARTHAGDTPGRFCYLGSVLHTQADRLEKSRSPIQFGAELYGHSGRASDLEIIRLMLEVLTTAGVERIHLDLGHVGIFRGLARQAGLTGEQEGELFSLLQQKARPELTAAVASLDIDPPLARMFTELVDLNGRHGVMERARECLSEANAAVHMALEELAVLAERLGDCCPEVPVNFDLAELRGYRYQTGVVFAAFVPGYGREIARGGRYDDIGKVFGRARPATGFSADLKVVLRLSGLGESFVGSGEAIFAPAVSDPALIAAIRELRDAGRIVIEALPGQQGDAAAHGFRSELRRNGERWCVCPVASKDT
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAA_YEAST
Sequence: MSSKPDTGSEISGPQRQEEQEQQIEQSSPTEANDRSIHDEVPKVKKRHEQNSGHKSRRNSAYSYYSPRSLSMTKSRESITPNGMDDVSISNVEHPRPTEPKIKRGPYLLKKTLSSLSMTSANSTHDDNKDHGYALNSSKTHNYTSTHNHHDGHHDHHHVQFFPNRKPSLAETLFKRFSGSNSHDGNKSGKESKVANLSLSTVNPAPANRKPSKDSTLSNHLADNVPSTLRRKVSSLVRGSSVHDINNGIADKQIRPKAVAQSENTLHSSDVPNSKRSHRKSFLLGSTSSSSSRRGSNVSSMTNSDSASMATSGSHVLQHNVSNVSPTTKSKDSVNSESADHTNNKSEKVTPEYNENIPENSNSDNKREATTPTIETPISCKPSLFRLDTNLEDVTDITKTVPPTAVNSTLNSTHGTETASPKTVIMPEGPRKSVSMADLSVAAAAPNGEFTSTSNDRSQWVAPQSWDVETKRKKTKPKGRSKSRRSSIDADELDPMSPGPPSKKDSRHHHDRKDNESMVTAGDSNSSFVDICKENVPNDSKTALDTKSVNRLKSNLAMSPPSIRYAPSNLDGDYDTSSTSSSLPSSSISSEDTSSCSDSSSYTNAYMEANREQDNKTPILNKTKSYTKKFTSSSVNMNSPDGAQSSGLLLQDEKDDEVECQLEHYYKDFSDLDPKRHYAIRIFNTDDTFTTLSCTPATTVEEIIPALKRKFNITAQGNFQISLKVGKLSKILRPTSKPILIERKLLLLNGYRKSDPLHIMGIEDLSFVFKFLFHPVTPSHFTPEQEQRIMRSEFVHVDLRNMDLTTPPIIFYQHTSEIESLDVSNNANIFLPLEFIESSIKLLSLRMVNIRASKFPSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKMNLSHNKLNFIGDLSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDTLPKLRALEIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMWPLFNCFVNLKVLNLSYNNFSDVSHMKLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQLKYNISNYHYDWNWRNNKELKYLNFSGNRRFEIKSFISHDIDADLSDLTVLPQLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRRLQPEISPPTGNLAMVFTDIKSSTFLWELFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTPTSGLTWCLSVQLKLLDAQWPEEITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKESLKEVYGEEIIGEVLEREIAMLESIGWAFFDFGEHKLKGLETKELVTIAYPKILASRHEFASEDEQSKLINETMLFRLRVISNRLESIMSALSGGFIELDSRTEGSYIKFNPKVENGIMQSISEKDALLFFDHVITRIESSVALLHLRQQRCSGLEICRNDKTSARSNIFNVVDELLQMVKNAKDLST
What is the function of this protein?
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
What are the official names of this protein?
Adenylate cyclase, ATP pyrophosphate-lyase, Adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-3 family.
Protein: KATG_CHESB
Sequence: MDAKTDDSAGKCPFTGGGRRGHRNRDWWPEQLDLDVLHRNSTLSDPMGEDFDYAEEFKSLDLNAVIQDLHALMTDSQDWWPADFGHYGGLMIRMAWHSAGTYRITDGRGGAGAGQQRFAPLNSWPDNANLDKARRMLWPIKQKYGRKISWADLMILAGNVALESMGFKTFGFAGGRKDVWEPEELFWGPEGTWLGDERYSGERQLSEPLAAVQMGLIYVNPEGPNGNPDPVAAAKDIRETFYRMAMNDEETVALIAGGHTFGKTHGAGDPSLIGPDPEGAAIEDQGLGWKSGHGTGFGADTITGGPEVTWSQTPTRWSNYFFENLFGYEWELTKSPAGAWQWKAKNAEATVPDAHDPSKKHVPTMLTTDLSLRFDPIYEKISRRFLENPDQFADAFARAWFKLTHRDMGPKVRYLGPLVPKETLIWQDPIPEVDHVLVDDQDIAGLKAKILASGLSVSELVSTAWASASTFRGSDKRGGANGARIRLAPQKDWEVNDPAQLAKVLQRLEAIQGEFNAAQAGGKKISLADLIVLGGCAAVEKAARDAGVDVKVPFTPGRMDASQEQTDIDSFRALEPRADGFRNYLSGRQFMMPEEALVDRAQLLRLTAPEMTVLLGGLRVLGANSGGSEHGVLTKQVGKLTNDFFVNLLTMNTQWQPIADGTYEGRDRKTNELKWRATRVDLIFGAHSQLRALAEVYACGDSQEKFVQDFVAAWTKVMNADRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: MSHA_MYCTA
Sequence: MAGVRHDDGSGLIAQRRPVRGEGATRSRGPSGPSNRNVSAADDPRRVALLAVHTSPLAQPGTGDAGGMNVYMLQSALHLARRGIEVEIFTRATASADPPVVRVAPGVLVRNVVAGPFEGLDKYDLPTQLCAFAAGVLRAEAVHEPGYYDIVHSHYWLSGQVGWLARDRWAVPLVHTAHTLAAVKNAALADGDGPEPPLRTVGEQQVVDEADRLIVNTDDEARQVISLHGADPARIDVVHPGVDLDVFRPGDRRAARAALGLPVDERVVAFVGRIQPLKAPDIVLRAAAKLPGVRIIVAGGPSGSGLASPDGLVRLADELGISARVTFLPPQSHTDLATLFRAADLVAVPSYSESFGLVAVEAQACGTPVVAAAVGGLPVAVRDGITGTLVSGHEVGQWADAIDHLLRLCAGPRGRVMSRAAARHAATFSWENTTDALLASYRRAIGEYNAERQRRGGEVISDLVAVGKPRHWTPRRGVGA
What is the function of this protein?
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol (MSH) biosynthesis pathway (By similarity).  MSH and WhiB3 are probably part of a regulatory circuit that mediates gene expression upon acid stress (like that found in host macrophage phagosomes).  MSH is one of the major redox buffers which protects bacteria against redox stressors and antibiotics; loss of MSH or ergothioneine (ERG, the other major redox buffer in this bacteria) leads to respiratory alterations and bioenergetic deficiencies that negatively impact virulence (By similarity).  Note that is strain is avirulent (PubMed:18584054).
What are the official names of this protein?
D-inositol 3-phosphate glycosyltransferase, N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase, GlcNAc-Ins-P N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. MshA subfamily.
Protein: EPC2_XENTR
Sequence: MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNVHYYSRLYKGEFKQPKQFIHIQPFNLDYEQPDYDMDSEDETLLNRLNRKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKSVYDYWVRKRKNCRGPSLIPQVKQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEVSYEKMLKLRREFSRAITILEMIKRREKTKRELLHLTLEVVEKRYNLGDFGGEILNEIKIPKVEKEIHVIPPSLHNGNHHKVPECKVKNTHHPSVKDEVLEIVRLKKKYPKKPKAETLVTPQPQATSEPLAVINKSDIKQYDFQSSDDDEFPQVPSPLSELEEENDPDGSYAFRRRTGCQYYAPRLDQMNDTPETTDLSGLARHRYRHCLTTLTVPRRCIGFARKRLGRGGRVIMDRLSTEHDSILKQIDPEMLSGFSSSSHVAQPPSSPSRTNASDRHCENRLSLPEILSNIKSCRLQCFQPRLLHTQDSDREECTSRLGQAVNVKRVSAALLNTSKNGITVTGGITEEQFQTHQQQLVQMQRQQLAQLQQKQQSQQSLQQSHPKAQGSAKSDCMSKTLDSASALFAASAVVNSPTPGRSEVNKDQNAGHSNLNGVVQPSGTAKTLYSTNMALSSSPGISTVQLVRTVGHPTTNHLIPTLCTSNPQTLTMGNSCLANTVHLNNVSVVSPVNVHINTRTSAPSPTALKLATVAASMDRVPKVTPSSAISSIARENHEPERLGLNGIADTTVAMEVT
What is the function of this protein?
May play a role in transcription or DNA repair.
What are the official names of this protein?
Enhancer of polycomb homolog 2.
What is the protein family that this protein belongs to?
Belongs to the enhancer of polycomb family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GAR1_CAEBR
Sequence: MSFRGGRGGGGGGGFRGGRGGGGGGGFRGGRGGDRGGGGFRGGRGGGGRGGFGGGGRGGYDQGPPEEVVLVGVFSHKCQDDIVCNNTSGKIPYFNAPIYFENKEQVGKIDEIFGSPGENGFSVTLSQGVKASSFKSGSELYIDPGKLLPVERFLPQVGGGRGRGGRGRGGDRGRGGDRGRGGFGGRGGGGGGFRGGSRGGFGGGDRGGFRGGRGGDFGGRGRGGDFKRSYDGGGYGGNSNKRTKFD
What is the function of this protein?
Required for ribosome biogenesis.  Part of a complex which catalyzes pseudouridylation of rRNA.  This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1.  Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
What are the official names of this protein?
Probable H/ACA ribonucleoprotein complex subunit 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the GAR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: COA5_PONAB
Sequence: MPKYYEDKPQGGACGGLKEDLGACLLESDCVVQEGKSPRQCLKEGYCNSLKYAFFECKRSVLDNRARFRGRKGY
What is the function of this protein?
Involved in an early step of the mitochondrial complex IV assembly process.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 5.
What is the protein family that this protein belongs to?
Belongs to the PET191 family.
Protein: OPUCD_BACSU
Sequence: MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLGILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRNTYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGTFVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGNFIIADRKTTSI
What is the function of this protein?
Involved in a high affinity multicomponent binding-protein-dependent transport system for glycine betaine, carnitine and choline; probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Glycine betaine/carnitine/choline transport system permease protein OpuCD.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL6_GLAP5
Sequence: MSRVAKAPVAVPAGVQVTLNGQLLTVKGKNGELSREIHNAVEVKYEADTLTFAPKAGIVNADAQAGTARALVNAMVIGVTEGFTKKLQLVGVGYRAQMKGNTVALNLGFSHSVEHELPAGVTGECPSQTEIILKSADKQLIGQVAADIRAYRKPEPYKGKGVRYADEVVRIKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: THIO_ECOL6
Sequence: MSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
What are the official names of this protein?
Thioredoxin 1, Trx-1.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
Protein: RL7_GEOKA
Sequence: MMTKEQIIEAVKNMTVLELNELVKAIEEEFGVTAAAPVVVAGGAAAGAEAAAEKTEFDVILADAGAQKIKVIKVVREITGLGLKEAKDLVDNTPKPIKEGIAKEEAEEIKAKLEEAGAKVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: Y1681_HAEIN
Sequence: MKLRAVVLGLATLCTSTATFAGMVSTSSNLEFLAIDGQKASKSLGKAKTFTVDDTQNHQVVVRLNEIVGSGSNQSLFESNPVIVTFQGNAEDLVISAPVIRNLDSGDKFNQMPNITVKTKSGNAISAKVDVLKQEGLFPSGNVLNDLAEYNASGAAASVSKFAATTVASSVAVAPAGNAKANKGKVVVQGENVAEQQLQYWFQQADKETQTRFLNWAKSHK
What are the official names of this protein?
UPF0319 protein HI_1681.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: KCY_SALDC
Sequence: MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDLASEDALVPLASHLDVRFVSTDGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAFREAPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQENGFSVNFERLLAEIKERDDRDRNRAVAPLVPAADALVLDSTRLSIEQVIEKALQYARQKLALA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPE8_CAEBR
Sequence: MSGVELQPESTQSEEKEEPKTAATTISSTEETKTENPNVALDNLAKTPIQLILQPTPQTPAKTPETPRIQKINNLKKSASFDSKNQPEDSKTPKQRDQLIEVPSDEVGRVENNIDNLPFYHGFMGRTECESMLSNHGDFLIRMTEVGRRVAYVISVRWHYQNSHVLVKRTKTKKLYWTKKYAFKSICELIAYHKLNQIPFYDNMTLICGLARHEWQLNNEQVTLNKKLGEGQFGEVHKGKLKPNVIKFYGVCTMKEPIMIVMEFCDGSSLEDVLLSKESKVSSEDKILYLFHAACGIDYLHGKHVIHRDIAARNCLLNSKKVLKISDFGLSVKGVAIKERKGGCLPVKYMAPETLKKGFYSTASDIYSYGALVYEVYTDGKTPFESCGLRGNELRKAIIGKSVILTIDVECPEFVKAIFEQSRLYDTEQRISSKRIIEIFKEEAGMHELDATGLFGRIGSFFSRVRRQKEAEPSVPILT
What is the function of this protein?
Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.
What are the official names of this protein?
Spermatocyte protein spe-8, Defective spermatogenesis protein spe-8.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Localizes mainly in the cytoplasm in stage I spermatocytes and at the cell membrane in stage II spermatocytes and in spermatids.
Protein: DEF_RICTY
Sequence: MSIYSIVTAPDERLKQKSKPVLECTDQTRKFMHDMLETMYNANGAGLAAVQVGVLQRILVIDIKAHDPVERPKDFYPLFIVNPEIIEQSTELVTANEGCISLPEQRIEVMRPESVKIRYLDYHGKSQELKANDWLARVIQHEYDHLEGKLMVDYLSNLKRDVVLRKLKKLKNNIV
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: KSL6_ISORU
Sequence: MFSSSLKLKTNPLMDNKIHRSSSDRDFRGSTISSVKCSLNNSEDLIVKVRERVKGKVEISPSAYDTAWVAMVPERDYSGQKPRFPECLDWIVENQNADGSWGVQSSSMLKHSLSCTLACLLPLRKWNVASPQLLRNGVEFIRSSSSAATDKNQISPIGFDIVFPMMIQYANDLNLELLLNQDLVNILFQNREAQLTRNKNLEYVAEGLGSSIDWNKVLMHQRSNGSLFNSPATTAAALIHRHDKKCLEYLNSLLSIYKTWVPTIHPMDVYARLCLVDHLQGLGVDRFVHPEIEVVLQETFRLWQQKDDKIFTDATCRAMAFRLLRMQGYHVTPDELGGYVDEESFFATVSFESSGTDTVLELYKASQVRLPEDDDTLEKLHDWTSKFLKQKLQSKTILDQQLERKVEFNLKNYHGILDAVKHRRNFDLYDIDHRRILKTAYRCPTVYNEDILLLTAQDLMTRQVQNQKELQIMERWLEDCRLDKVSGRNAVLVSYFLNANNFPDPRLSEARLAYAKTVTLITFLDDFFDHHGSREDSLLIMELINKWTEPLTVSYPSDEVEILYSALHATITDTAEKVYAVQGRCIKSLIIELWMEVLTAMLGEMDSCNADTPPDFDEYMAFAPKSLGCSLSILPSLHLMGETISEEMVTSLECFELDKHVSIAIRLLNDQQTFERERKERTTNSVTLLMDADQISEEEAVSRIQKLIEHHTKELLKLVVQKEGSVLPRKCKDIFWNTIKVGYCLYRFSDEFTSPQQMKEDMKLLFHDPVLKTTP
What is the function of this protein?
Involved in the biosynthesis of ent-kaurene diterpenoids natural products such as oridonin, miltiradiene, eriocalyxin B and nezukol, known to exhibit antitumor, anti-inflammatory and antibacterial activities (PubMed:28381502).  Catalyzes the conversion of (+)-copalyl diphosphate ((+)-CPP) to isopimaradiene (PubMed:28381502).
What are the official names of this protein?
Isopimaradiene synthase, Kaurene synthase 6, IrKSL6.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YM3_STRCO
Sequence: MWEDSLTVFCGIDWAERHHDVAIVDDTGTLLAKARITDDVAGYNKLLDLLAEHGDSSATPIPVAIETSHGLLVAALRTGSRKVFAINPLAAARYRDRHGVSRKKSDPGDALVLANILRTDMHAHRPLPADSELAQAITVLARAQQDAVWNRQQVANQVRSLLREYYPAALHAFQSKDGGLTRPDARVILTMAPTPAKAAKLTLAQLRAGLKRSGRTRAFNTEIERLRGIFRSEYARQLPAVEDAFGHQLLALLRQLDATCLAADDLAKAVEDAFREHADSEILLSFPGLGPLLGARVLAEIGDDRSRFTDARALKSYAGSAPITRASGRKHFVGRRFVKNNRLMNAGFLWAFAALQASPGANAHYRRRREHGDWHAAAQRHLLNRFLGQLHHCLQTRQHFDEQRAFAPLLQAAA
What are the official names of this protein?
Mini-circle putative transposase for IS117.
Protein: TGT_PHOPR
Sequence: MKFELDKTQGRARRGRLQFERGTVETPAFMPVGTYGTVKGMTPEEVKETGAQILLGNTFHLWLRPGQEVMKLHGDLHDFMQWHGPILTDSGGFQVFSLGATRKITEEGVHFRNPVNGDKVFMDAEKSMEIQYDLGSDIVMIFDECTPYPATHDEAKKSMEMSLRWAQRSRNHFDKQENPNALFGIIQGGVYEDLRDVSVDGLTNIGFDGYAVGGLAVGEPKEDMHRILEHTCPQLPEDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTGGVIKIRNAKHKTDTTPLDPHCDCYTCLNYSKAYLYHLDKCNEILGSRLNTIHNLRYYQRLMASIRSAIEEDRFDVFVEEFYARRDREVPPLKNA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NSP4_ROTHP
Sequence: MDKLADLNYTLSVITLMNDTLHSIIQDPGMAYFPYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVIKYCIVTIINTLLKLAGYKEQVTTKDEIEQQMDRIVKEMRRQLEMIDKLTTREIEQVELLKRIHDNLITRSVDVIDMSKEFNQKNIKTLDEWESGKNPYEPSEVTASM
What is the function of this protein?
The secreted form acts as an enterotoxin that causes phospholipase C-dependent elevation of the intracellular calcium concentration in host intestinal mucosa cells.  Increased concentration of intracellular calcium disrupts the cytoskeleton and the tight junctions, raising the paracellular permeability.  Potentiates chloride ion secretion through a calcium ion-dependent signaling pathway, inducing age-dependent diarrhea.  To perform this enterotoxigenic role in vivo, NSP4 is released from infected enterocytes in a soluble form capable of diffusing within the intestinal lumen and interacting with host plasma membrane receptors on neighboring epithelial cells such as integrins ITGA1/ITGB1 and ITGA2/ITGB1.
What are the official names of this protein?
Non-structural glycoprotein 4, NSP4, NCVP5, NS28.
What is the protein family that this protein belongs to?
Belongs to the rotavirus NSP4 family.
What are the subcellular locations of this protein?
Host rough endoplasmic reticulum membrane; Single-pass type III membrane protein. Host membrane, host caveola; Single-pass type III membrane protein. Secreted. Note=NSP4 localizes also in vesicular structures which contain autophagosomal markers and associate with viroplasms in virus- infected cells. Additionally, a soluble form of glycosylated NSP4 is secreted despite retention of its transmembrane domain.
Protein: LIPA_COLP3
Sequence: MSNDLTSESKTANRAAGEKFRDADKLAHIPIKVVSSTKATMLRKPSWLRIKLPKSSERIDNIKANLRKNDLHSVCEEASCPNLSECFNHGTATFMILGDICTRRCPFCDVGHGRPLAPKSDEPKKLANSLKDMGLKYVVITSVDRDDLRDGGAQQFADCVKEIGEQAPNTKVEILVPDFRGRMDRALEILNQNPPHVFNHNMETAPRLYTKVRPGANYQWSLDLLKRFGEANPDVTTKSGLMVGLGETNEEILEVMQDLRDHGVTMLTVGQYLQPSKDHLAVERYVHPDDFAMFEREAKKMGYEHAACGPLVRSSYHADKQAAGEEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECOT_SALTY
Sequence: MKMFVPAVVFAALASASAWANNGDTAQPLEKIAPYPQAEKGMKRQVITLTPQQDESTLKVELLIGQTLNVDCNQHRLGGTLETKTLEGWGYDYYVFDNVTSPVSTMMACPEGKKEQKFVTAWLGEDGMLRYNSKLPIVVYTPANVDVKYRIWKADANVQNAVAR
What is the function of this protein?
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
What are the official names of this protein?
Ecotin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
What are the subcellular locations of this protein?
Periplasm.