PharMolix/UniProtQA huggingface dataset:
Protein: RBSA_CERS4
Sequence: MSGLAIDMTGISKAFGPVKALVDADLRVARGTIHGLVGQNGAGKSTIIKVLAGILKPDSGRITINGTRVESLTPASVERLGVHFIHQERLLVPTATVAEAVFLNYELRFGPFLRPGAMKRRAEELIRTHFGLELPGDTLVRDLTTAQQKIVQITRALAQEAQVLVLDEPTAALVKREVDSLFAVLRNLRAQGIAVIFISHYMQEIEDLCDEVTVMRNGTDVGVVRPGETSIDEIVSMMIARDVGEMFPCRSHALGAPVLRVEGLSQAGHFRNVSFEVRAGEVLGITGLLGSGVKELVECLFGLEQPDAGSVTIDGEVRRFANPGRAVQGRVALVPEDRRAHGVATDMSVRDNITIASLERYMTRGFVSRARENEAVDGFIRELSIKTPHRDQLVRNLSGGNQQKVALAKWLSCQSRVYVLDEPTVAVDVGAKVEIYTLLNRLAAEGAAILFLSSDLLEIAGFCDRALVVYRGTLNGEFAGETLDSDLLLAAASGARAQRKEA
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GPMI_BACCR
Sequence: MRKPTALIILDGFGLREETYGNAVAQAKKPNFDGYWNKFPHTTLTACGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFDKNETFQSAIKSVKEKGTALHLFGLLSDGGVHSHMNHMFALLRLAAKEGVEKVYIHAFLDGRDVGPKTAQSYIDATNEVIKETGVGQFATISGRYYSMDRDKRWDRVEKCYRAMVNGEGPTYKSAEECVEDSYANGIYDEFVLPSVIVNEDNTPVATINDDDAVIFYNFRPDRAIQIARVFTNEDFREFDRGEKVPHIPEFVCMTHFSETVDGYVAFKPMNLDNTLGEVVAQAGLKQLRIAETEKYPHVTFFFSGGREAEFPGEERILINSPKVATYDLKPEMSIYEVTDALVNEIENDKHDVIILNFANCDMVGHSGMMEPTIKAVEATDECLGKVVEAILAKDGVALITADHGNADEELTSEGEPMTAHTTNPVPFIVTKNDVELREDGILGDIAPTMLTLLGVEQPKEMTGKTIIK
What is the function of this protein?
Essential for rapid growth and for sporulation.  Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: HTPX_VIBA3
Sequence: MKRVMLFLATNLAVVLVLSVVLNIVYAVTGMQPGSLSGLLVMAAVFGFGGSFISLMMSKKMALRSVGGMVIESPRNETEHWLMETVSRQSQQVGIGMPTVAIYDSPDINAFATGAKRNDSLVAVSTGLLHNMTRDEAEAVLAHEVSHIANGDMVTMTLMQGVVNTFVIFLSRFIANIVASNDNEEEGGSNMMVYFGVSMVLELVFGFLASFITMWYSRHREFHADADAAHLVGKEKMIAALERLKVSHEPQLEGSMMAFGINGKKSLTELLMSHPPLDKRIASLRNM
What are the official names of this protein?
Protease HtpX, Heat shock protein HtpX.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL10_IGNH4
Sequence: MSAITGRVSTYHREKFPEWKVKLVNEVKEKLKENDVVLVLDLVETPANLVHKFRKKFRKELPYMKVIKNNLVRKAFEQSGIEMPKEMDEQLVGSNMFIFTNDNPFKLALKISKFSMPAPAKPGDVAQSEIVVPAGDTGLTPGPILSTFGKLKIKTMVKGGTIHIAKDTVVAKPGDVISPELASLLQKLGITPMELKMKIKGAYIKSLNRWVPAEELVLDLNKYKEQIQEAYTNALALGVSIAYPVPEVLKLSVAKAFQDALKVAVEAGWLTKETAPYLLSKAYAQALALVGALGDKAKELGIEVEVPAAPAPEAKEEKKEEAEEEEEEKKEVSEEDLSAGLGALFG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10, Acidic ribosomal protein P0 homolog.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: AROB_CLOP1
Sequence: MKVLRVNLDEKSYDIVIQKDLKDYFGEYIKTVFDGKKVAIITDDNLNDIYGEAIKKNIENEGFEVEVISVTPGEKSKSFSVLPGIYNKLLDFKLTRSDLIIALGGGVVGDLAGFVASTFLRGISFIQIPTSLLAQVDSSVGGKVAVDLERGKNLVGSFYHPELVLIDPNMLGTLPEKYFNDGLGEVIKYGCIKSKELFEKLEGFENKEDLKENIGEIIYECCNIKREVVENDEKDLGERMILNFGHTLGHAIEQIYNYETYSHGEAVAIGMNMISKIAEEKDLTKKGTAERIESLLKKYGLNTDVNIEDNGLAREAIKLDKKNLNGNLNVILLKDIGEGYIYNTTVEFFE
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_FRATO
Sequence: MINDILKDAENRMKKSLEVLADDLAKIRTGRAHPDLLAHVTIDYYGVETPITQAANITVLDARTLGITPWEKGLSSKIEKAILTSDLGLNPTNLGDSLRVPMPALNEERRKELVKLVKSETEAGRVSIRNIRRDANGDIKELLKEKEITEDQAKKAEDDIQKITDKMIAQADALAAKKEQDLMAV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DIMB_DICDI
Sequence: MNQFYQSTTGGQQNNNNGNQFQQYQPQQQQQFQQYSPSNANNNNTTTTTTTSTSKKGKNKDNQSKQQQIQQQQIQQQQQQQQQQQQQIQQQSVDTPSSYNGDGSDDGSDTERENKKNRNRVNQNLASRNYRQRKKEYIKEIEEKLAVLALENDQLKKENINLKKGGGVEIMKPDPAFITMMMEAKQIIIQLDVAIKKNDERSLIYLLQLFHLSIEKRHTIVEREVEKMVHPYTQAKLAAMGYVPSLENPMISSISGPSSDGWWTMYISEAQITEEQAKAIKQLRSNHWKADIELRNEREKLDRSIKEFYLNRVMVFPTNERLNKSFATNLSLSDGPNPTSPNSSSVTQSTLVRPSPGLTLLNNLNEENNNSNNSSNSSNNNTTTNNNNNNSLTPTPNQNNNISNIAVNGTISVVNELGFSPINGNIDISEILEFTRKLEALKKNFVKQRTLMEDTHSALSSILTPKQEAMLLVRVHSSTRYDFANMEMLKNVWGSVIAKDTTSYPQPPTFSQQTQQLQQAQLQLQNQTKQQQQQLQNNNNNNNNNNNNNNSFNNSNNNNVQNNSSNPSTPGGNNDQQNIYYTSSPSIPSSPYNHHQQQPSRQ
What is the function of this protein?
Transcriptional regulator involved in DIF-1 signaling.  DIF-1 (Differentiation Inducing Factor-1) is a signal molecule involved in the differentiation of pstO (prestalk-O) cells (By similarity).  May be a direct activator of ecmA.
What are the official names of this protein?
Basic-leucine zipper transcription factor B.
What is the protein family that this protein belongs to?
Belongs to the bZIP family.
Protein: TEG_PRIM2
Sequence: MTKYRIITFDGGGTLGALSLQLLNRLAYQNPKLISETNVFSGNSIGSFTALALASGRSPEETFDFFKDQILPAFSVSRPGGPVFNQQVPYSGLIKAIRTFFPRDLRLRDLKKRIVVPAFHLFAPELNRWNPVLFHNFLGSPYLNEKASDVILRSSAAPATQRAYQNYVDGYTVATNTSTASIAFAVGKAKQPLDQIAVLSIGTGEQPTQLRRDTKGWGMVSADNILPEDMEDLPPNWGVLLDRSPNEPLLPFLQIISGGSSYYESMVSSELLGDQFFRLNPRIPNFSKTDPSVVPALISIANKTNLRPAFQFIERNWN
What is the function of this protein?
Probable lipid hydrolase.
What are the official names of this protein?
Protein teg.
Protein: RL2_BEII9
Sequence: MALKTFKPITPSLRQLVIVDRSNLYKGKPVKQLTEGKSSSGGRNNNGRVTVRFRGGGHKQTYRIIDFKRRKLDMPAKVERIEYDPNRTSFIALIRYADDELSYIIAPQKLAVGDEVISGQQVDVKPGNAMALANMPVGTIVHNIEMKIGKGAAMVRSAGTYAQVVGRDQGYVIVRLNSGEQRLIHGQCFATVGAVSNPDHMNASIGKAGRSRWLGRRPHNRGVTMNPVDHPHGGGEGRTSGGRHPVTPWGKPTKGKKTRTNKSTDKFIVTSRHKSKKKG
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: NHR47_CAEEL
Sequence: MSEKLPPGTLCAVCDDIATGKHYSVASCNGCKTFFRRALVNNREFVCQGNKDCPVNKGVRCACRYCRLQKCLAVGMDKNSIQNDRDRIGYTKRKRRHDDNDMEGGVHHSEHIRDGSSGSPQMNDESPESMDMKDIKIDLNCLDPIADRLTTLENNFTLLLSRCADLHSYATLEDALNAPSRFMQPISCEWSDNVVLTNRDDKLPFWRQRLIALYIDWAKTFSTFRSLPYADKVAMVTNHASSFMIMCEAFRTPEHMKSDVVRKRPDLPNIVTSNSGSGCSRVSSVAGSLVSNGEDVHDDLTNLLHAACIQQSINKGIMFGENSSDDKILLNLPIREIKKEPLEVPSTEGMIQLPTEYGNLPADYASWIPQDYGHPTAGHEGKSDMHNFFEARDFCVGRPSSCNLNERSMKTVSMLESRNFQSPSANNSSLSGITPVLTMMIDLVMKPFRQLNFSTTEFALLQAIMFFDPDTEGLDSASQRNVVAEQKKLLAVLFRHLQKAYNPQAASERYASIILRMPSIRRAAAKKNESLQVLDMLQMHEINSLVKETSLGPRPSNVQQRMGIGGGAGGCLTFPSQED
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-47.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GNAS_CRIGR
Sequence: MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVVKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).  Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP.  GNAS functions downstream of several GPCRs, including beta-adrenergic receptors.  Stimulates the Ras signaling pathway via RAPGEF2.
What are the official names of this protein?
Guanine nucleotide-binding protein G(s) subunit alpha, Adenylate cyclase-stimulating G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(s) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: Y2273_YERE8
Sequence: MGYFIDRRLNGKNKSMVNRQRFLRRYKSQIKQSISDAINKRSVTDIESGESVSIPIDDINEPMFHQGRGGLRHRVHPGNDHFITNDRIERPQGGGGGSGSGQGNAGQDGEGEDEFVFQISKDEYLDLLFEDLALPNLKKNQYKQLTEFKTHRAGYTSNGVPANISVVRSLQNSLARRTAMTASKRRELRELEETLKALENSEPAQLLEEERIRKAIAELKQKIARVPFIDTFDLRYKNYERRPEPSSQAVMFCLMDVSGSMDQATKDMAKRFYILLYLFLSRTYKNVDVVYIRHHTQAKEVDEQEFFYSQETGGTIVSSALKLMDEVVQERYDPAQWNIYAAQASDGDNWADDSPLCHELLAKKILPVVRYYSYIEITRRAHQTLWREYEDLQAKYENFAMQHIREPEDIYPVFRELFHRQTVDN
What are the official names of this protein?
UPF0229 protein YE2273.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: MFS1_AJECA
Sequence: MVTLSNVGADVEKNIVPEVNDASKRDSDNASADFQPGVKRVRAVASVWSKKTLWLTFALLYLVAFVDMLLVSVQSTLNPFITSSFEKHGLLASVSIVATILSGCSTLTLAKIVDVWGRIEGFLFMLLVVVVALIMKATCKNMEAYVAAHTLYWTGHIGMIYCVDVMLADMTTLRNRMIMFSINNTPTIASTFAGPKIADLFFSNLNFRWAFGAFAIMLVGVSLPVIVIMLFMERKSVKAGFLVKEKSGRSAWESIKYHLIEFDVVGIVLITASFALILLPFSIVVYAPKGWATGYIIAMEVVGVVCGAIFLAWERFLAPVQFLPFKYLKNPTIIGSCLLYGVMFASALLTITTAGYVLNSFSLSSAILAPGIGLYTGNFKWAAYAGIPFMLLGTALLIPFRQPNTSIGAVTITQVLVGIGTSFFSVCGQLAVMSVVSHQEVAVVLAIWGMFGSIGASVGLAVAGAMWNNILPSQLYRRLPEESKAMAAQIFGDMQLQMSYLDGTPERDAIVGAYADVQRKMVIAGVCMMPLVMASIVIWRNVNIKKQEEEEGSQTTGNIF
What is the function of this protein?
Major facilitator transporter involved in siderophore transport (PubMed:18404210).
What are the official names of this protein?
MFS siderochrome iron transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IFI27_HUMAN
Sequence: MEASALTSSAVTSVAKVVRVASGSAVVLPLARIATVVIGGVVAMAAVPMVLSAMGFTAAGIASSSIAAKMMSAAAIANGGGVASGSLVATLQSLGATGLSGLTKFILGSIGSAIAAVIARFY
What is the function of this protein?
Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766).  Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806).  Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746).  Also functions in TNFSF10-induced apoptosis (PubMed:24970806).  May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340).  May thereby play a role in the vascular response to injury (By similarity).  In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077).  May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077).  Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 (PubMed:36426955).
What are the official names of this protein?
Interferon alpha-inducible protein 27, mitochondrial, p27, Interferon alpha-induced 11.5 kDa protein, Interferon-stimulated gene 12a protein, ISG12(a), ISG12A.
What is the protein family that this protein belongs to?
Belongs to the IFI6/IFI27 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Exclusive localizations in either the nucleus or the mitochondrion have been reported.
Protein: BIOC_SALTY
Sequence: MAQVNKQAIAAAFGRAASQYEQHASLQQHSADALLTLLTGRQFASVLDAGCGPGRMSRYWRERGSEVTALDLSLPMLQQARDRQAAHHYLLADIEAIPHDAEVFDLAWSNLAVQWCGDLRDALSELYRVVRPGGVVAFTTLCQGSLPELRQAWQAVDNRAHANSFLPEEAIDHALRGWRAFRHTQAMTLWFEDALSAMRSLKGIGATHLHEGRESDVLTRARLRQIQLAWPQRQGKYPLTYHLFMGVIERD
What is the function of this protein?
Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM).  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
What are the official names of this protein?
Malonyl-[acyl-carrier protein] O-methyltransferase, Malonyl-ACP O-methyltransferase, Biotin synthesis protein BioC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
Protein: COBQ_PSEPF
Sequence: MTTLMVQGTTSDAGKSTLVTALCRWATRQGVAVVPFKPQNMALNSAVTADGGEIGRAQAVQAQAAFLEPHTDMNPVLLKPNSDTGAQVIIHGRAVTSMNAVAYHDYKAIAMQAVLASHERLSAAYPLVMVEGAGSPAEINLRAGDIANMGFAEAVDCPVLLIADINRGGVFAHLVGTLELLSPSEQARIKGFIINRFRGDIALLQPGLDWLEQRTGKPVVGVLPYVMDLHLEAEDGIDQRQTDKAEQVLKVVVPVLPRISNHTDFDPLRLHPQVDLQFIGPGQAIPPADLIILPGSKSVRSDLAYLRANGWESAIRRHLRYGGKLLGICGGLQMLGEQVHDPLGLEGAPGSSAGLGLLAFETQLEAEKQLRNVRGRLALEDAEVSGYEIHAGVTTGAALEKAAVHLDDGRCDGAQSLDGQIFGTYLHGLFESPAASAALLRWAGLYDVQEVDYHGLRERDIERLADLVEKHLDTGLLRELCGISPCSS
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: RS7_STRPQ
Sequence: MSRKNQAPKREVLPDPLYNSKIVTRLINRVMLDGKRGTAATIVYDAFSAIKEATGNDALEVFETAMDNIMPVLEVRARRVGGSNYQVPVEVRPERRTTLGLRWLVNASRARGEHTMKDRLAKEIMDAANNTGASVKKREDTHKMAEANRAFAHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: DUT_TROWT
Sequence: MTVEVLFKGGYTPQRAFDGDAGFDLQSSHTAVIQPRCRQVVKTGIAIALPDGYAGFIMPRSGLASENGITLVNSPGVIDAGYRGEISVVLINTDLHQAFHISQGDRIAQLVIMPVCHASFIEVDTLPGSARGISAFGSSGRHDTRG
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: RUVB_SERP5
Sequence: MIEADRLISAEPINEEEILDRAIRPKLLTEYVGQPHVREQMEIFIQAAKQRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAAMLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGSLTSPLRDRFGIVQRLEFYQVADLQHIVSRSANCLGLDLSEEGAHQVARRARGTPRIANRLLRRVRDFAEVRANGVINGEVAMQALDMLNVDAEGFDYMDRKLLLAIIDKFTGGPVGLDNLAAAIGEERETIEDVIEPFLIQQGFIQRTPRGRMATNHAYKHFGMVREE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PYCC_GULMO
Sequence: MRSSHKSFDFENSLKRIDSILNDSTSYEESDDIPDIDDLTFNNGKYVNCAAIFIDLRGSTDLIKTLGKLSKSLARLYRAYISEMVAIVNSFKTCKEINIVGDCVSAMFAGDIEGAESPVIEALQASSMANAMMNVLNVKYKKKWKDFVELKAGIGVAYGRALVIKAGFSGSGIKDLVYMGDVVNKASKMCGLAYKEYTSHAICVTKEVYENAGKYIANEEKKLTYQDFLTEKNHNTFGSVYVGNFHRVYINNWAEENK
What is the function of this protein?
The pyrimidine cyclase gene of a two-gene Pycsar system, weakly generates cyclic UMP (cUMP) from UTP, has little to no activity on ATP, CTP or GTP (PubMed:34644530).  Expression of this and adjacent effector GmPycTM (AC P0DV43) probably confers resistance to bacteriophage.  The genes are probably only expressed in response to bacteriophage infection (Probable).
What are the official names of this protein?
Uridylate cyclase, Cyclic UMP synthase, cUMP synthase, GmPycC.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Pyrimidine cyclase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1071_HAEDU
Sequence: MSLQFNPIGLFLVALILLGVLGNNNSITISATLLLLMQQTALNKYIPMLEKYGLTIGIIILTIGVLSPIVSGKINLPNLSEILSWKMALAISIGIFVAWLGGRGINLMATQPLIITGLLIGTIIGIAFFGGIPVGPLIAAGIMSLLVGKL
What are the official names of this protein?
UPF0756 membrane protein HD_1071.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RLF30_ARATH
Sequence: MKAWVICLMVISIFMMIEPTLAAGGGKFLNPGVLDPCLRPNPPPECQAPGSAGKPRERVNEYKVGCSKLTRCDRVG
What is the function of this protein?
Cell signaling peptide that may regulate plant stress, growth, and development.  Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2+) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity).
What are the official names of this protein?
Protein RALF-like 30.
What is the protein family that this protein belongs to?
Belongs to the plant rapid alkalinization factor (RALF) family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y5G1_ENCCU
Sequence: MDTILGILNVQKLHTTSKHQENKDKPPETRRRGTINSILLAMSTVFPVFVFFTHREDGFDGNILLRFTTLVFPFSYSAAQHFLLLSSNWGSSCRSSSGLYRALCLALNALLAVFFVISICSLILFTADEWDDNEALTICSMLFPSLLLSSTCLLSISCNFATFQFVDSGPDIPIDLLIFLCLVILHKTSPLEDYEYLPYFAIPSFILVLVRSFKERLLPRKSSPPAAAWRVAVFLLILVLTISVYVFISRVCWAVIESKWEALTSD
What are the official names of this protein?
UPF0328 protein ECU05_1610/ECU11_0120.
What is the protein family that this protein belongs to?
Belongs to the UPF0328 family.
Protein: SPE2_THECC
Sequence: YQGVYPVKSNQDRFVVEDIVKFGSSFRFGLEAGSKPELLLAMSCLCKGNPEALLVCNGFKDAEYISLALLARKLALKHVIVLEQEEEVDMVIDISQKLSVRPVIGVRAKLRTKHSGHFGSTSGEKGKFGLTTTQVLRVVKKLQDSGMLDCLQLLHFHIGSQIPSTALLSDGVGEAAQIYSELVRLGARMKVVDFGGGLGIDYNGSKSGDSDLSVPYGLQEYAHVVNAIRFVCDRKSVKHPVICSESGRAIVSHHSILIFEAICLTAPATHNEPINIPFIMEGLSEDACADYWNLRDTAMRTGDGAFWFYADQWKQRCVEQFKEGTLGIEQLASVDGLCEWVLKAIGASDPVHTYNINLSVFTSIPDLWGIDQLFPIVPIHKLDQRPGARGILSDLTCDSDGKINKF
What are the official names of this protein?
Arginine decarboxylase, ADC, ARGDC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: GPI11_YEAST
Sequence: MPAKKRTRKTVKKTVSFSDDTTLTTHQNREKKNVDHDRPPVYVRKTPLMTFPYHLVALLYYYVFVSSNFNTVKLLSFLIPTQVAYLVLQFNKCTVYGNKIIKINYSLTIICLGVTFLLSFPTMLLTILFGAPLMDLLWETWLLSLHFAFLAYPAVYSVFNCDFKVGLWKKYFIFIVVGGWISCVVIPLDWDRDWQNWPIPIVVGGYLGALVGYTIGAYI
What is the function of this protein?
Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.  Required for the formation of complete GPI precursors CP1 and CP2.
What are the official names of this protein?
Glycosylphosphatidylinositol anchor biosynthesis protein 11, PIGF homolog.
What is the protein family that this protein belongs to?
Belongs to the PIGF family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SPCS2_DICDI
Sequence: MSTTTTTTTTEKPIQVTLYDSNTIKQTLDDSIVKYVTSALSYTQNQKLNYTKVLFGLIGCTLAAIAQFYPIPFPKNKPVLILCVALYVVISLILYYINIFIQKDYILQASKSNDEIKVATVLQKYDPNYQVKIENAKNSSINVPFSKSIDLYFDTKGTFLESNFHNDLSVQFKKFAKLNVKDK
What is the function of this protein?
Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity).
What are the official names of this protein?
Signal peptidase complex subunit 2.
What is the protein family that this protein belongs to?
Belongs to the SPCS2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MINY1_DANRE
Sequence: MADSCADTVDGEIKGFSEGQQLNITKNEDLEQTKPQKEAIANTEESSACVSQIKQDLAPCKDPPTTTTASLEDDAKATSSASVTSKSQDESEVINSQSYTPSQSEATPSFSMASLEFSEENNGVPPDGPLSSAKSARDGNQVSVQENEGAVAGAMRPAEPTMPAYYFVKWITWKEKKTAVITQSENGPCPLIAIMNILLLRWKVKFPAQTEVVTTEELMAHLGECVLSIKPREKAEGMELNFQQNMSDAMAVLPKLSTGLDVNVRFTGVSDFEYTPECIVFDLLDIPLYHGWLVDPQSPEVVSAVGKLSYNQLVEKIIEFKHSTDSSQVSEGLIAEQFLESTATQLSYHGLCELNTTAKEGELSVFFRNNHFSTMIKHKGHLYLLVTDQGFLQEESVVWESLHNVEGDGNFCDSDFRLCHPSQKPSAAAAQPSTQQQQQMQIDQDYLVAMSLQQEQGEAPGPLSDLELARQLQQEEYQQPQTQQQQQQQPSAGQMRGQATSPQGGQRRREKKEETDCCIL
What is the function of this protein?
Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins.  May play a regulatory role at the level of protein turnover.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase MINDY-1, Deubiquitinating enzyme MINDY-1, Protein FAM63A.
What is the protein family that this protein belongs to?
Belongs to the MINDY deubiquitinase family. FAM63 subfamily.