PharMolix/UniProtQA huggingface dataset:
Protein: DPMAF_METAN
Sequence: MTRLSLQLIAGLAGQAWLVNSDTPSHEAFASCLSDASVPIATKGTPEWTQHTTPFNTRLQYEPIAVAVPTEISQIAAAVTCAKKNSIPVTAKSGGHSFTSLGLGGEDGHLVIQLDRMYNVELAQNGTARIQSGARLGHVAVELYNQGKRALSHGYCPAVGVGGHAAHGGYGMVSRKYGLTLDWMKDATVVLHNGTIVYCSESEHSDLFWAIRGAGSSFGIVAEYGFETFPAPEKVTNFGIVLDWNPETAPAGLLAFQDFAQTMPSELSCQIDVRSTGYTLNGSYVGNEASLREALVPLLGKIGGHLEVHEGNWLEYVKFWAFGQPNIDITPPADNVHLSLYTTGALTPSLSANQFKSFADYIAKDAIKRGNSWSIQMFIHGGQNSAISGPKITDTAYAHRDKFLIFQFTDFVWPSQEYPEDGLALGREFRDIITNSFTNDQWGMYANVPDSQLSSGEAQKLYWGKNLERLETIKAKYDPSNLFRNPQSVKAAARCATHPLLLQGQCLLF
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the diterpenoid pyrones subglutinols A and B (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpmaA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpmaD through the action of the prenyltransferase dpmaC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpmaE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpmaB (Probable).  The dehydrogenase dpmaF is then involved in tetrahydrofuran (THF) ring formation at the C5 unit to complete the formation of subglutinols A and B (PubMed:32286350).
What are the official names of this protein?
FAD-linked oxidoreductase dpmaF, Diterpenoid pyrone biosynthesis cluster protein F.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: MIA_BOVIN
Sequence: MAWSLVFLGVVLLSAFPGPSAGGRPMPKLADRKMCADEECSHPISVAVALQDYVAPDCRFLTIHQGQVVYIFSKLKGRGRLFWGGSVQGDYYGDGAARLGYFPSSIVREDQTLKPAKTDVKTDIWDFYCQ
What is the function of this protein?
May function during cartilage development and maintenance.
What are the official names of this protein?
Melanoma-derived growth regulatory protein, Cartilage-derived retinoic acid-sensitive protein, CD-RAP, Melanoma inhibitory activity protein.
What is the protein family that this protein belongs to?
Belongs to the MIA/OTOR family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1800_NATTJ
Sequence: MAGHSKWANIKHKKARVDEKRGKLFSKLSKEIIVAAKEGGGDPEKNFRLRMAVQKAKENNMPNDNIERAIKKGTGELKGFNYEEISYEGYGPGGVAIFLDAMTDNKNRTASEVRHIFTKNDGNLGEDGCVAWMFDRKGLITIDKEQAENIDEEELMLLTAEAGAEDFKSDNNSIEIVTTPQDFEQVREALENEEVPLSYKEVTMIPSNTVKVEGEEAKKVLQLMEELEDHDDVQNVYANFDIDDSLMETG
What are the official names of this protein?
Probable transcriptional regulatory protein Nther_1800.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_MYCTA
Sequence: MALTAEQKKEILRSYGLHETDTGSPEAQIALLTKRIADLTEHLKVHKHDHHSRRGLLLLVGRRRRLIKYISQIDVERYRSLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PHNW_BACFN
Sequence: MKPYLLLTPGPLTTSETVKETMMTDWCTWDEDYNLHIVESLRKELVGIATRNTEEYTSVLLQGSGTYCVEAVIGAAIGKNDKLLICSNGAYGDRMGNIAEYYHIDYELLAFDETEQVSVDYVDDYLSNNSDVTHVAFVHCETTTGILNPLKELAHVVKMPGKKLIVDAMSSFGGIPMDVSELGIDFLISSANKCIQGVPGFGFIIARRSELVRCKGVARSLSLDIYDQWETMEKGHGKWRFTSPTHVVRAFKQALTELIEEGGVEARHRRYCENHRVLVEGMRSLGFVTLLDDAIQSPIITSFLYPKTGFDFKAFYTALKSKGFVIYPGKISKADTFRIGNIGDVHPEDFARLVEVVRETEY
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: G6PD_YEAST
Sequence: MSEGPVKFEKNTVISVFGASGDLAKKKTFPALFGLFREGYLDPSTKIFGYARSKLSMEEDLKSRVLPHLKKPHGEADDSKVEQFFKMVSYISGNYDTDEGFDELRTQIEKFEKSANVDVPHRLFYLALPPSVFLTVAKQIKSRVYAENGITRVIVEKPFGHDLASARELQKNLGPLFKEEELYRIDHYLGKELVKNLLVLRFGNQFLNASWNRDNIQSVQISFKERFGTEGRGGYFDSIGIIRDVMQNHLLQIMTLLTMERPVSFDPESIRDEKVKVLKAVAPIDTDDVLLGQYGKSEDGSKPAYVDDDTVDKDSKCVTFAAMTFNIENERWEGVPIMMRAGKALNESKVEIRLQYKAVASGVFKDIPNNELVIRVQPDAAVYLKFNAKTPGLSNATQVTDLNLTYASRYQDFWIPEAYEVLIRDALLGDHSNFVRDDELDISWGIFTPLLKHIERPDGPTPEIYPYGSRGPKGLKEYMQKHKYVMPEKHPYAWPVTKPEDTKDN
What is the function of this protein?
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.  The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).
What are the official names of this protein?
Glucose-6-phosphate 1-dehydrogenase, G6PD.
What is the protein family that this protein belongs to?
Belongs to the glucose-6-phosphate dehydrogenase family.
Protein: SKP_ECOL6
Sequence: MKKWLLAAGLGLALATSAQAADKIAIVNMGSLFQQVAQKTGVSNTLENEFKGRASELQRMETDLQAKMKKLQSMKAGSDRTKLEKDVMAQRQTFAQKAQAFEQDRARRSNEERGKLVTRIQTAVKSVANSQDIDLVVDANAVAYNSSDVKDITADVLKQVK
What is the function of this protein?
Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.
What are the official names of this protein?
Chaperone protein Skp.
What is the protein family that this protein belongs to?
Belongs to the Skp family.
What are the subcellular locations of this protein?
Periplasm.
Protein: OBG_ANADE
Sequence: MKFVDEVKIHVKAGDGGDGAVAWRREKFIPRGGPAGGDGGNGGDVVLEVDPQLSTLLDYRYIREHKARNGEKGSGSDMNGKDGADLVLRVPPGTVVKDAATGEQLCDLGTAGERVVIAKGGRGGLGNMNFASSTNQAPRYAEDGTPGAERDLVLELKLLADVGIVGYPNAGKSTLISRISRARPKIADYPFTTLTPNLGVVGWRERSFVVADIPGLIEGAHAGAGLGHQFLRHVERCRVLIHLVEGANPEPGRAPKADLDAINAELAAYSDELAKKPQIVAVTKIDVPEARAAGVKLQKLLGRRKKPVPVHLVSAVTGEGLDALLDAVGRALFKEARPHRGGGGKKLAKPRARA
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S2513_HUMAN
Sequence: MAAAKVALTKRADPAELRTIFLKYASIEKNGEFFMSPNDFVTRYLNIFGESQPNPKTVELLSGVVDQTKDGLISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFEDVKQVFGQTTIHQHIPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNARTGRVTAIDFRDIMVTIRPHVLTPFVEECLVAAAGGTTSHQVSFSYFNGFNSLLNNMELIRKIYSTLAGTRKDVEVTKEEFVLAAQKFGQVTPMEVDILFQLADLYEPRGRMTLADIERIAPLEEGTLPFNLAEAQRQKASGDSARPVLLQVAESAYRFGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYIDFGGVKPMGSEPVPKSRINLPAPNPDHVGGYKLAVATFAGIENKFGLYLPLFKPSVSTSKAIGGGP
What is the function of this protein?
Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871).  Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton.  Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871).
What are the official names of this protein?
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial, Calcium-binding mitochondrial carrier protein Aralar2, ARALAR-related gene 2, ARALAR2, Citrin, Mitochondrial aspartate glutamate carrier 2, Solute carrier family 25 member 13.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SUR8_DROSI
Sequence: MNLCSSGATASTTSLSSTGQAERSGGVPGGGAEGGGGGGGSGNSGGGGKTSDVSAEASTLCFAGGSGTAGAITGTEELSNANSPANGAGGASGSTGSGQQPTGSNGHSHLHNENNANMPPETRPKMVTVKHPESNKPKPTTKKSKPIQADQDVIKALQRCRIKRLDLSKSSITVIPSTVKECVHLTELYLYSNKIGQLPPEIGCLVSLRNLALNENSLTSLPESLQNCSQLKVLDLRHNKLAEIPPVIYRLRSLTTLYLRFNRITAVADDLRQLVNLTMLSLRENKIRELGSAIGALVNLTTLDVSHNHLEHLPEDIGNCVNLSALDLQHNELLDIPDSIGNLKSLVRLGMRYNRLSSVPATLKNCKSMDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVYSINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMNLQNLEILILSNNMLKKIPNTIGNLRRLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITMLPRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLENLYINQNPGLEKLPFELALCQNLKYLNIDKCPLSTIPPEIQAGGPSLVLQWLKMHSPYRQIDCYYQYELQTVNQAPGAGGNGGGGAAAAGGSASRSSDRR
What is the function of this protein?
Acts as a Ras effector and participates in MAPK pathway activation.  Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation (By similarity).
What are the official names of this protein?
Leucine-rich repeat protein soc-2 homolog, Protein Sur-8 homolog, Protein soc-2 homolog.
What is the protein family that this protein belongs to?
Belongs to the SHOC2 family.
Protein: RBL_HUPLU
Sequence: MSPQTETKTSVGFKAGVRDYRLTYYTPNYKTKDTDILAAFRMTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYEIEAVTGEKNQFIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPAYSKTFIGPPHGIQVERDKSNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFVAEALFKAQAETGEIKGHYLNVTAGTYEELLKRAHCARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHAGTVVGKLEGERDVTLGFVDLLRDDYIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAREGNEIIREASQWSPESAAACEVWKEIKFEFEAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YUBB_ECOLI
Sequence: MPFDLLTVLFTRLDVEVNGFNGGVLNGVPSAYHWYTEQYGVKGPCGYEVNISSQGDNFIQVDFDTPWCQPESDVIAVLSRRFSCTLEHWYAEQGCNFCGWQRYERGELVDVLWGELEWSSPTDDDELPEVTAPEWIVDKVAHYGG
What are the official names of this protein?
Uncharacterized protein YubB.
Protein: GLYG2_SOYBN
Sequence: MAKLVLSLCFLLFSGCFALREQAQQNECQIQKLNALKPDNRIESEGGFIETWNPNNKPFQCAGVALSRCTLNRNALRRPSYTNGPQEIYIQQGNGIFGMIFPGCPSTYQEPQESQQRGRSQRPQDRHQKVHRFREGDLIAVPTGVAWWMYNNEDTPVVAVSIIDTNSLENQLDQMPRRFYLAGNQEQEFLKYQQQQQGGSQSQKGKQQEEENEGSNILSGFAPEFLKEAFGVNMQIVRNLQGENEEEDSGAIVTVKGGLRVTAPAMRKPQQEEDDDDEEEQPQCVETDKGCQRQSKRSRNGIDETICTMRLRQNIGQNSSPDIYNPQAGSITTATSLDFPALWLLKLSAQYGSLRKNAMFVPHYTLNANSIIYALNGRALVQVVNCNGERVFDGELQEGGVLIVPQNFAVAAKSQSDNFEYVSFKTNDRPSIGNLAGANSLLNALPEEVIQHTFNLKSQQARQVKNNNPFSFLVPPQESQRRAVA
What is the function of this protein?
Glycinin is the major seed storage protein of soybean (PubMed:2485233).  Glycinin basic peptides (GBPs), and, to a lower extent, glycinin exhibit antibacterial activity against Gram-negative and Gram-positive bacteria (e. g.  L. monocytogenes, B. subtilis, E. coli and S. enteritidis) by forming pores and aggregating in transmembranes, leading to membrane permeability and, eventually, cell death (PubMed:22236762, Ref. 21, PubMed:28590128).
What are the official names of this protein?
Glycinin G2, Glycinin 11S G2, Glycinin A2B1a.
What is the protein family that this protein belongs to?
Belongs to the 11S seed storage protein (globulins) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Protein storage vacuole. Note=Hexamers are assembled in the endoplasmic reticulum and later sorted to the protein storage vacuoles.
Protein: HVM29_MOUSE
Sequence: EVKLEESGGGLVQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWIAEIRLKSHNYATHYAESVKGRFTISRDDSKSSVFLQMNNLRAEDTGIHYCTTGFAYWGQGTLVTV
What are the official names of this protein?
Ig heavy chain V-III region E109.
Protein: DIK2A_MOUSE
Sequence: MWRLVPLKLGRLSRALKLAALGSLLVLMLLHSPSLLASWQRNELADRRFLQLNKCPACFGTSWCRRFLNGQVGFETWGRLRLLDFLNVKNVYFAQYGEPREGGRRRVVLKRLGSQRELAQLDQSICKRATGRPRCDLLQAMPRTEFARLNGDVRLLTPEAVEGWSDLVHCPSQRLLDRLVRRYAETKDSGSFLLRNLKDSERMQLLLTLAFNPEPLVLQSFPSDEGWPFAKYLGACGRMVAVNYVGEELWSYFNAPWEKRVDLAWQLMEIAEQLTNNDFEFALYLLDVSFDNFAVGPRDGKVIIVDAENVLVADKRLIRQNKPENWDVWYESKFDDCDKEACLSFSKEILCARVTVDHNYYAVCQNLLSRHATWRGTSGGLLHDPPSEIAKDGRLEALLDECTNPKKRYGRFQAAKELRGYLAQLSHNVR
What is the function of this protein?
May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PI3-kinase signaling cascade.
What are the official names of this protein?
Divergent protein kinase domain 2A, Deleted in autism protein 1 homolog, Golgi Protein of 49 kDa, GoPro49, Hypoxia and AKT-induced stem cell factor, HASF.
What is the protein family that this protein belongs to?
Belongs to the DIPK family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasmic vesicle, COPI-coated vesicle. Secreted.
Protein: RIMP_RUEST
Sequence: MTNDLIAKAAIDRRLAEIITPVIEDLGYELVRIRLMSGKTTTLQIMADRPDGGIEVDDCAAISNAVSATLDVEDPILDAYTLEVSSPGIDRPLTRLKDFDMFEGYEAKLETADLIDGRRRFKGELAGIEDDEVLINIEEHGETVTIGLKFDWLSDAKLVLTDDLIKEMLRQRKAAGVLNEDAFDDIETEGSAEGTTGSEEENK
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_CORGL
Sequence: MKHLLSISDLSKDEIVGLLDEADRFKEVLEGREVKKLPTLRGRTIFTLFYENSTRTRSSFETAGKWMSADVINISASSSSVKKGESLKDTGLTLSAIGADAIIMRHPASGAAQQLAQFVAPGGNGPSVINAGDGSHQHPTQALLDALTIRQRTGRIEGLKVVIVGDCLHSRVVRSNVDLLSTLGAEVVLVAPPTLLPIGVENWPVRFSYDMDAEIADADVVMMLRVQQERMQGGFFPSHREYATLYGMSKEREARLKDSAIIMHPGPMLRGMEINFQVADAPRTAVLQQVSNGVHMRMAILFALVAGSDATI
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: H2B1D_HUMAN
Sequence: MPEPTKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2B type 1-D, H2B-clustered histone 5, HIRA-interacting protein 2, Histone H2B.1 B, Histone H2B.b, H2B/b.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: Z385A_MOUSE
Sequence: MILGSLSRAGPLPLLRQPPIMQPPMDLKQILPFPLEPAPTLGLFSNYSTMDPVQKAVLSHTFGGPLLKTKRPVISCNVCQIRFNSQSQAEAHYKGNRHARRVKGIEAAKTRGREPSVRESGDPAPAGSIPPSGDGVAPRPVSMENGLGPAPGSPEKQPGSPSPPSVPESGQGVTKGEGGTSVPASLPGGSKEEEEKAKRLLYCALCKVAVNSLSQLEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNSEVQLKQHISSRRHRDGVAGKPNPLLSRHKKPRGAAELAGTLTFSKELPKSLAGGLLPSPLAVAAVMAAAAGSPLSLRPAPAAPLLQGPPITHPLLHPAPGPIRTAHGPILFSPY
What is the function of this protein?
RNA-binding protein that affects the localization and the translation of a subset of mRNA.  May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation.  Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation.  With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A.  Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity.  May also bind CCNB1 mRNA.  Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction.  Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes.  May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest.  Also plays a role in megakaryocytes differentiation.
What are the official names of this protein?
Zinc finger protein 385A, Hematopoietic zinc finger protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite. Note=Detected in dendrites of Purkinje cells and hippocampal neurons.
Protein: MTNK_KLEP3
Sequence: MSQYHTFTAHDAVAYAQQFAGIDNPSELVSAQEVGDGNLNLVFKVFDRQGVSRAIVKQALPYVRCVGESWPLTLDRARLEAQTLVAHYQHSPQHTVKIHHFDPELAVMVMEDLSDHRIWRGELIANVYYPQAARQLGDYLAQVLFHTSDFYLHPHEKKAQVAQFSNPAMCEITEDLFFNDPYQIHERNNYPAELETDVAALRDDAQLKLAVAALKHRFFAHAEALLHGDIHSGSIFVAEGSLKAIDAEFGYFGPIGFDIGTAIGNLLLNYCGLPGQLGIRDAAAAREQRLNDIHQLWTTFAERFQALAAEKTRDAALAYPGYASAFLKKVWADAVGFCGSELIRRSVGLSHVADIDTIQDDAMRHECLRHAITLGKALIVLAERIDSVDELLARVRQYS
What is the function of this protein?
Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
What are the official names of this protein?
Methylthioribose kinase, MTR kinase.
What is the protein family that this protein belongs to?
Belongs to the methylthioribose kinase family.
Protein: DAPH_CALS4
Sequence: MINLNTNDNLTNAYEIARYIKEAKKSTPVKAYVQGKIQVEEEEGLKIFGSEDFKILIGELEVVEKVIEQNKDRIKYYHLEYDRRNSAIPLLDITHLDARIEPGAIIRDKVKIGKNAVIMMGAVINIGAEIGENSMIDMNAVIGARGIIGKNVHVGAGAVIAGVLEPPSSVPVVIEDNVMIGANAVILEGVRVGRGAVVAAGSVVIEDVPPNTVVAGVPAKIVKVVDEKTREKTKLMEDLRG
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: RUVB_AZOVD
Sequence: MIEADRLITATGQDREEQQDRAIRPLRLAEYIGQPVVREQMELFIQAARGRREALDHTLIFGPPGLGKTTLANIIAQEMGVSLKSTSGPVLERPGDLAALLTNLESGDVLFVDEIHRLSPVVEEVLYPAMEDFQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGMLTNPLRDRFGIVQRLEFYSVADLTTIVGRSAAILGLPTDAEGAFEIARRARGTPRIANRLLRRVRDFAQVRGEGRITRQIADLALNLLDVDEHGLDHQDRRLLLTLIEKFDGGPVGVDSLAAAISEERHTIEDVLEPYLIQQGYMMRTPRGRVVTRHAYLHFGLNLPARMEATMADPLADAPADGE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: NTPPB_VIBPA
Sequence: MKNYQLVLASTSPFRQQLLEKLSVPFICLSPDCDETPYESEAPLDLVQRLAVNKATSCSIKKPSLVIGSDQVCVIDGKIVGKPLNRENAINQLLAQSGKAITFYTGLAVYNSVTNLTEVGYDTFEVHFRNLNREQIERYVDREEPFYCAGSFKSEGMGICLFEKLVGKDPNTLVGLPLIDLIDMLQKQGFEIL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP).  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
7-methyl-GTP pyrophosphatase, m(7)GTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YceF subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2098_DICDI
Sequence: MDIPIIKLLVEKDSISKKYYCPDCGELLINNFNPEKFKALQCKNGHTKCLQCWEQHLKLRKNCLQCKVPVSSIKDLSLNLYIAQKISANKVYCKNRYYETKNFTIDEENGCKEIIRVDEYEKHIKECPLTYTDCKNYDDFIRANPQIDEKLLKRCGKINKSLLDEHDEQCLYQTITCEHCNELINRIDHEIHLSEWCSDIPIKCEDCKHVFKKKYIQEHKESNCPESVIDCVYVAGGCQKKLKRYNMSKHLVTANHHSQYMSKIIEEQNQDIKELHNFIENHLSKKFIDLDTIVNIQKYLIKNKNQKISQLTEIIKRVDNSFIGLHEFDELEDYISNTIDIISNFDNYKNSNSNNNNNNKNTNENENTNENTNENENIDIVGNSDNENNINENKAENNINSFIKEQIELIKIKSQQFDINSVIEEIRKNYNVEPYQVNGDNAMITSPNKTDVDNLVFDDDEDDFDLEEPQIVGEFIFNKSQETIAIPTLIRQQQQQQQQQQQQQQQQQQQPPPTPLPPQNTTITNDIQMENINENINNNINENNNNNNKNNDDDNITAATATNNSNTTSTHTILNGTNNEASMTDINETTSTTTTAETTEATASESTEESNNTAETTTTTTTTTTTITTAAETVNSTETITLRTSEKVEEKGKDGLETTESFSILNSTENSTISSLKVLSNSMIEPEITTDKENETNIKESIETKIIESIVESSSPTKSLLKQGKEQEQKNQNGNGNENENENENENENENENENENENANANVNEKENEKENSNINTSNDTEPTNDILEDIKKNKENEDSNESEDNKNNNIKSVEDTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNENVYDIKKDRNRENVEDSNDNNSKNENGKINDNGDVKMGSEDKVNDDDDKMAMVDRSNTIFRNQILFKDFTKLNARHGVGVSIKHNHTIGKYKFYSELFINGETENEKDYLSFYLNKCKKENESIIISFGIELLNVDPKKSIRVYWDNELLNNSSQVMYNYGYGETTVIKKSILEDPNNGFLVDNCFIVNLEVYKIIDVPHPPPAHLLQKSSPPAATTTTTTSSSSSKTTPKTKR
What is the function of this protein?
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
What are the official names of this protein?
TNF receptor-associated factor family protein DDB_G0272098.
What is the protein family that this protein belongs to?
Belongs to the TNF receptor-associated factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_ACTSZ
Sequence: MSKQSLSYKDAGVDINAGNELVERIKPHVKRTTRSEVIGGLGGFGALCALPAKYKEPVLVSGTDGVGTKLRLAIDLKKHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDVAADVVKGIAEGCVQSSCALVGGETAEMPGMYREGDYDLAGFCVGVVEKSKILDGSKVQAGDALIALASSGPHSNGYSLVRKVIEVAGVNPATEQLAGKPLAEQVLAPTKIYVKSVLELIEKTDVHAIAHLTGGGFWENIPRVLPENVKAVIDETSWDWQPVFKWLQEQGNITRHEMYRTFNCGVGMVLALPQAEADKALDILRAAGENAWLIGRIEALNAGEQQVIIR
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.