Protein: NFAC4_MOUSE
Sequence: MGAASCEDEELEFKLVFGEEKEPPPLGPGGPGEELDSEDTPPCCRLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGNAGGAGGGRVLECPSIRITSISPTPDPPTSLEDTSETWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSPRASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPVPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSPGPFDYVGAPPTESIPQKTRRTSSEQAVALPRSEEPPSCNGKLPSGTEDSVAAPGALRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVETYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFKFLPVVFKEEPLPDSSLRGFPSTSGPPFGPDVDFSPPRPPYPSYPHEDPAYETPYLSEGFGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSSFALGLPFSPPAPFRPPLPSSPPLEDPFHPQSAIHPLPPEGYNEVGPGYTPGEGASEQEKARGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPARPGEEPPA
What is the function of this protein?
Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems.  Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:17198697).  Along with NFATC3, involved in embryonic heart development (PubMed:12750314, PubMed:17198697).  Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (PubMed:12750314).  Transactivates many genes involved in heart physiology.  Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714).  Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (By similarity).  Binds to and transactivates AGTR2 gene promoter (PubMed:17198697).  Involved in the regulation of adult hippocampal neurogenesis.  Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons.  Involved in the formation of long-term spatial memory and long-term potentiation (PubMed:22586092).  In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (PubMed:18354019).  Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP).  Plays a role in adipocyte differentiation.  May be involved in myoblast differentiation into myotubes (By similarity).  Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable).  In the presence of CREBBP, activates TNF transcription.  Binds to PPARG gene promoter and regulates its activity (By similarity).  Binds to PPARG and REG3G gene promoters (PubMed:17198697).
What are the official names of this protein?
Nuclear factor of activated T-cells, cytoplasmic 4, NF-ATc4, NFATc4, T-cell transcription factor NFAT3, NF-AT3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (By similarity). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (By similarity).