PharMolix/UniProtQA huggingface dataset:
Protein: ENO_NEIG2
Sequence: MSAIVDIFAREILDSRGNPTVECDVLLESGVMGRAAVPSGASTGQKEALELRDGDKSRYSGKGVLKAVEHVNNQIAQALIGIDANEQSYIDQIMIELDGTENKGNLGANATLAVSMAVARAAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGGEHANNSLNIQEFMIMPVGAKSFREALRCGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLNSHKEALQLMVEAAEAAGYKAGEDVLFALDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLEGLVNEFPIISIEDGMDENDWEGWKLLTEKLGKKVQLVGDDLFVTNPKILAEGIEKGVANALLVKVNQIGTLSETLKAVDLAKCNRYASVMSHRSGETEDSTIADLAVATNCMQIKTGSLSRSDRMAKYNQLLRIEEELAEAAYYPGKAAFYQLGK
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: DAPA_METLZ
Sequence: MFEGVIPALITPFNDDASQSLDIEGLRNCIEYVIRGGVHGLLACGSTGESATMTHAEHIRVIEETVSAASNRIPAIAGTGSNNTEEALLMTRAAKMSGADGVLLISPYYNKPNRSGLLKHYRKVADIGLPVIVYNIPGRTGQNLPADLIIEMVETIPNLVAVKEASGNLDQMMAIIQGTQDLDREYPFILTSGDDSLTLPVLSVGGHGCISVTANIEPKRLVEMYDLFRRSDVKAAMKKHYELMDLSKALFMEVNPVPVKRAAEIRGLINSGNVRLPLDSLGEQNTAILRGVLSRYD
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CURS2_CURLO
Sequence: MAMISLQAMRKAQRAQGPATILAVGTANPPNLYEQDTYPDYYFRVTNSEHKQELKNKFRLMCEKTMVKRRYLYLTPEILKERPKLCSYMEPSFDDRQDIVVEEVPKLAAEAAENAIKEWGGDKSAITHLVFCSISGIDMPGADYRLAQLLGLPLAVNRLMLYSQACHMGAAMLRIAKDIAENNRSARVLVVACEITVLSFRGPDERDFQALAGQAGFGDGAGAMIVGADPVLGVERPLYHIMSATQTTVPESEKAVGGHLREVGLTFHFFNQLPAIIADNVGNSLAEAFEPIGIKDWNNIFWVAHPGNWAIMDAIETKLGLEQSKLATARHVFSEFGNMQSATVYFVMDELRKRSAAENRATTGDGLRWGVLFGFGPGISIETVVLQSVPL
What is the function of this protein?
Catalyzes the synthesis of curcumin by condensing feruloyl-CoA with a diketide-CoA in the curcuminoid biosynthesis.
What are the official names of this protein?
Curcumin synthase 2.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.
Protein: STON1_HUMAN
Sequence: MCSTNPGKWVTFDDDPAVQSSQKSKNFPLENQGVCRPNGLKLNLPGLREFPSGSSSTSSTPLSSPIVDFYFSPGPPSNSPLSTPTKDFPGFPGIPKAGTHVLYPIPESSSDSPLAISGGESSLLPTRPTCLSHALLPSDHSCTHPTPKVGLPDEVNPQQAESLGFQSDDLPQFQYFREDCAFSSPFWKDEGSDSHFTLDPPGSKKMFSSRNKEMPIDQKSLNKCSLNYICEKLEHLQSAENQDSLRSLSMHCLCAEENASSFVPHTLFRSQPKSGWSFMLRIPEKKNMMSSRQWGPIFLKVLPGGILQMYYEQGLEKPFKEIQLDPYCRLSEPKVENFSVAGKIHTVKIEHVSYTEKRKYHSKTEVVHEPDIEQMLKLGSTSYHDFLDFLTTVEEELMKLPAVSKPKKNYEEQEISLEIVDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLNDLELPKRDESYYEKDSEKKGIDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLYNGDNLPFSLKSVVVVQGAYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTMNLQRQKSLKAKMNRRACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSLDHPHCLSYKLELGSDQEIPSDWYPFATVQFSVPDTCASRTEVRSLGVESDVQPQKHVQQRACYNIQVEIEKKWIKIDGEDPDKIGDCITQ
What is the function of this protein?
May be involved in the endocytic machinery.
What are the official names of this protein?
Stonin-1, Stoned B-like factor.
What is the protein family that this protein belongs to?
Belongs to the Stoned B family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Some fraction is membrane- associated.
Protein: ACHB4_RAT
Sequence: MRGTPLLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSLVRVPHPSQLHLATADTAATSALGPTSPSNLYGSSMYFVNPVPAAPKSAVSSHTAGLPRDARLRSSGRFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGLFLPPLFQIHAPSKDS
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit beta-4, Neuronal acetylcholine receptor non-alpha-2 chain, N-alpha 2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: TDCB_STAAS
Sequence: MTTNTVTLQTAHIVSLGDIEEAKASIKPFIRRTPLIKSMYLSQSITKGNVFLKLENMQFTGSFKFRGASNKINHLTDEQKEKGIIAASAGNHAQGVALTAKLLGIDATIVMPETAPQAKQQATKGYGAKVILKGKNFNETRLYMEELAKENGMTIVHPYDDKFVMAGQGTIGLEILDDIWNVNTVIVPVGGGGLIAGIATALKSFNPSIHIIGVQSENVHGMAESFYKRDLTEHRVDSTIADGCDVKVPGEQTYEVVKHLVDEFILVTEEEIEHAMKDLMQRAKIITEGAGALPTAAILSGKINNKWLEDKNVVALVSGGNVDLTRVSGVIEHGLNIADTSKGVVG
What is the function of this protein?
Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction.  The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate).  Both intermediates are unstable and short-lived.  The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia.  In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
What are the official names of this protein?
L-threonine dehydratase catabolic TdcB, Threonine deaminase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: SECA_THENN
Sequence: MLFFDKNKRILKRYSKIVEKINQLDQSMRKKSNEEIVSLSSELKERVNSLEDADRNLVEAFALVREAARRTLGMRPFDVQVMGGIALHEGKVAEMKTGEGKTLAATMPVYLNALIGKGVHVVTVNDYLARRDALWMGPVYLLLGLRVGVINSLGKSYEVVWKDPSLVEKAIKENWSVWPQEFDGEILKEEQMNKEALNAFQVELKEISRKEAYMCDVTYGTNNEFGFDYLRDNLVLDYNDKVQRGHFYAIVDEADSVLIDEARTPLIISGPSKESPSTYRRFAQIAKKFVKDKDFTIDEKARTVILTEEGVAKAEKIIGVDNLYEPGNVSLLYHLINALKALHLFKKDVDYVVMNGEVIIVDEFTGRLLPGRRYSGGLHQAIEAKEGVPIKEESITYATITFQNYFRMYEKLAGMTGTAKTEENEFVQVYGMEVVVIPTHRPMIRKDHDDLVFRTQKEKYEKIVEEIEKRYKKGQPVLVGTTSIEKSELLSSMLKKKGIPHQVLNAKHHEKEAEIVAKAGQKGMVTIATNMAGRGTDIKLGPGVAELGGLCVIGTERHESRRIDNQLRGRAGRQGDPGESIFFLSLEDDLLRIFGGEQIGKVMKILKIEEGQPIQHPMLSKLIENIQKKVEGINFSIRKSLMEMDEVLDKQRSTIYSLRDQILLEKDYDEYLKQIFEDVIGTRVEEFCSGKNWDLEGLKNSLSFLPRDLFEFDGRRFESSEELYEYLFNRMWEEYQKKRQEIGEEYSKVIRFLMLRIIDEHWRRYLEEVEHVREAVQLRAYGQKDPIVEFKKETYLMFDEMMRRINDTIANYVLRVVKVTEKDEKEAKEELGKIRLVHEEFNLVNRAMRRAMEKGKKKGGSHGLGKIRVKR
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ARLY_SULAC
Sequence: MLYRRWGSDKDFVISYTSSNESDKEIVEEVKLTLKAHVIELYLSNYISKDTAKKIIRAINSFKDYPSSGYEDVHEALEDYIIKNIGEEGGWVGLGRSRNDHVATALRLRTREYIFDIMEELYLLRKSLIEQAKKNLNTIMPSYTHFQPAQPTTLAHYFMYLEEELNTPWEALFNSLKLINRSPLGSGAIVGSNVKIDRKREAELLGFDDVLYNTISSTSSRIDFINAISSLTLLMLVLSRFAEDMILLSSMFVNIIKLPDSHVSTSSLMPQKRNSVTMEILRTKVGECYGDLSSLMMIYKGLPSGYNLDLQEMNKHYWNCIKHVIPSIHITRDIIQNIQIKNFGEIQGLTATDLAEEMAISGIPYRKAYIDVANKIKAGTFVAGISYTKSIENKKVIGSPNPSLLTQEIEIKEKRLNNQHEKFKQYKESVIEKMGQLGVIEDGLLQQ
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDIA4_HUMAN
Sequence: MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL
What are the official names of this protein?
Protein disulfide-isomerase A4, Endoplasmic reticulum resident protein 70, ER protein 70, ERp70, Endoplasmic reticulum resident protein 72, ER protein 72, ERp-72, ERp72.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
Protein: YNEA_BACP2
Sequence: MRLKESIIFIGVFSFIVGIFLSLIAVTSHNDPNQYVKIEVQSGDTLWGLADQVNDSKSIDKNAFIDWVTQHNDLASTEIQPGDILVIPVKKEHPFVYQLATVQ
What is the function of this protein?
Inhibits cell division during the SOS response.  Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC to the division machinery.
What are the official names of this protein?
Cell division suppressor protein YneA.
What is the protein family that this protein belongs to?
Belongs to the YneA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUA9_PONAB
Sequence: MAAAAQSRVVRVLSMSRSAITAIATSVCHGPPRRQLHHALIPHGKGGRSSVSGIVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDTYDIMHLRPMGDLGQLLFLEWDARDKDSIRRVVQHSNVVINLIGRDWETRNFDFEDVFVKIPQAIAQLSKEAGVEKFIHVSHLNANIKSSSRYLRNKAVGEKVVRDAFPEAIIIKPSDIFGREDRFLNSFASMHRFGPTPLGSLGWKTVKQPVYVVDVSKGIVNAVKDPDANGKSFAFVGPNRYLLFHLVKYIFAVAHRLFLPFPLPLFAYRWVARVFEISPFEPWITRDKVERMHITDMKLPHLPGLEDLGIQATPLELKAIEVLRRHRTYRWLSAEIEDVKPAKTVNI
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial, Complex I-39kD, CI-39kD, NADH-ubiquinone oxidoreductase 39 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA9 subunit family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PYRB_CITK8
Sequence: MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGANQHPTQTLLDLFTIQETQGRLDNLNIAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIEEVMAEVDILYMTRVQKERLDPSEYANVKAQFVLRASDLNGARENMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSDLAL
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: CARY_BACSU
Sequence: MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRVILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVELEETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAESIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEYEVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALDVVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDELKNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAAIQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHEKTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEVRALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPIRIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVNVAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELGLKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSMPYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGLQQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIPLATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAYDSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHINLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ
What are the official names of this protein?
Carbamoyl-phosphate synthase arginine-specific large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: AROC_CALMQ
Sequence: MSSIGVVFRVTTFGESHGPAVGVVIDGVPAGIQLNEDYIRRELNRRRFCHIPVLNPRCEDEDFQILSGIKDGLTTGTPIAIVVWNKRAVSNYYMDIWMKPRPGHADLAWYLKFGKLYDFRGGGRASGRETVARIAAGAVAKAILKQTIDVDVSSHLIELGGVSISRDDYTFNDVAKSWEKPLPMIDDEAIEKAIKVLINAATEGDSVGGIGEVLTTEVPPGLGEPVFDKLKADLAKAVMSIPSTTGIEFGLGFKLARMRGSEANDQIVLRNGKPRLETNRVGGMLGGMSIGEPIRFRVAFKPTPSIRRPQRTVDLEKITETTITFTGRYDISTAPKAILAAEAMTAIILVDHAIRAGLIPRIIRK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: GSKIP_MOUSE
Sequence: METDYNPVELSSMSGFEEGSELNGFEGADMKDMQLEAEAVVNDVLFAVNHMFVSKSMPCADDVAYINVETKERNRYCLELTEAGLRVVGYAFDQVEDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS
What is the function of this protein?
A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets.  The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively.  Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B.  During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity).  May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (PubMed:26582204).
What are the official names of this protein?
GSK3B-interacting protein, GSKIP.
What is the protein family that this protein belongs to?
Belongs to the GSKIP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RERG_HUMAN
Sequence: MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYDPTLESTYRHQATIDDEVVSMEILDTAGQEDTIQREGHMRWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSACTGEGNITEIFYELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS
What is the function of this protein?
Binds GDP/GTP and possesses intrinsic GTPase activity.  Has higher affinity for GDP than for GTP.  In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.
What are the official names of this protein?
Ras-related and estrogen-regulated growth inhibitor.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CISY_SCHPO
Sequence: MMIILNAPRFMTNTRLASTRRLASSLLSQASLRSRQLNPLFTSSYSTRSSSLKDRLAELIPEKQAEIKKFRAEHGQDVIGEVTINQMYGGARGVRSLIWEGSVLDPNEGIRFRGYTIPECQKLLPSSPNGKQPLPESLFWLLVTGEIPTLSQVQALSADWAARSQLPKFVEELIDRCPPTLHPMAQFSLAVTALEHDSAFAKAYERGMNKHDYWKYEYEDCMDLIAKTVPIAGRIYRNLYRDGVVAPIQMDKDHSYNFANVLGFANNEEFVELMRLYLTIHADHEGGNVSAHTGHLVGSALSSPFLSMAASLNGLAGPLHGLANQEVLNFLITMKKEIGDDLSEETIKSYLWKLLNSGRVVPGYGHAVLRKTDPRYTAQREFALEHLPKDPMFQLVSRLYEIVPGVLTEHGKTKNPYPNVDSHSGVLLQYYGLKEQSFYTVLFGVSRTLGVASQLIWDRALGLPIERPKSFSTEALKKMVETK
What are the official names of this protein?
Probable citrate synthase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the citrate synthase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RSMH_LEUCK
Sequence: MAEFEHVTVLLHEAVALLAINPTGTYVDATLGGGGHTGEILKQLTTGKLYSFDQDDTAIKYNQTRYADEIAAGKLILIHQNFRQLKVALAEQHVTAVDGIVYDLGVSSVQFDDGQRGFSYNYDAELDMRMDQRQTLTAKTIVNDWPFNDILRVLSRYGEDRFPKQVARKIEQHRDKGPINTTFELVDIIKEAIPAPARRKGGHPAKRTFQALRVAVNDELGALEDSLTQALELLAPSGRISVITFQSLEDRLVKQMFREKTSMPDLPAGLPVLPGQFEPDYKLLTRKPILPSETEMTDNHRSESAKLRGIERQ
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H71_CONVC
Sequence: MNTAGRLLLLCLALGLVFESLGIPVADDVEAVRDTDPDEKDPSVHNSLKAVYGDCGGERCRFGCCKTDDGEEKCQHFGCP
What is the function of this protein?
Probable toxin with unknown function (Probable).
What are the official names of this protein?
Conotoxin Vc7.1, H_Vc7.1.
What is the protein family that this protein belongs to?
Belongs to the conotoxin H superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PP306_ARATH
Sequence: MAAKSQKTLVLLANLIKFPPLKAFSLLNSPNFHEFQHTHESISILLRLLLSGNLFSHAQSLLLQVISGKIHSQFFTSSSLLHYLTESETSKTKFRLYEVIINSYVQSQSLNLSISYFNEMVDNGFVPGSNCFNYLLTFVVGSSSFNQWWSFFNENKSKVVLDVYSFGILIKGCCEAGEIEKSFDLLIELTEFGFSPNVVIYTTLIDGCCKKGEIEKAKDLFFEMGKLGLVANERTYTVLINGLFKNGVKKQGFEMYEKMQEDGVFPNLYTYNCVMNQLCKDGRTKDAFQVFDEMRERGVSCNIVTYNTLIGGLCREMKLNEANKVVDQMKSDGINPNLITYNTLIDGFCGVGKLGKALSLCRDLKSRGLSPSLVTYNILVSGFCRKGDTSGAAKMVKEMEERGIKPSKVTYTILIDTFARSDNMEKAIQLRLSMEELGLVPDVHTYSVLIHGFCIKGQMNEASRLFKSMVEKNCEPNEVIYNTMILGYCKEGSSYRALKLLKEMEEKELAPNVASYRYMIEVLCKERKSKEAERLVEKMIDSGIDPSTSILSLISRAKNDSHVSSK
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At4g11690.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
Protein: RR14_CYAM1
Sequence: MAKSSVKEREKKREQLIKRYEKKRKEIKQQIIEASTLKQKWQAYEKLSQLPKDSSPVRQRRRCWLTGRSRGVYRYFGLCRHMVRKMAHEGLLAGVTKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SEC62_KLULA
Sequence: MSEPSPQSTIAIANLLRTHSDLKQRQGLFQSRLVDFFRYKRFVRALKSDKYKAKSKKQPELYPAVTSDEDARNIFVSLIKAQFVVPAVKLHSAECKEHGLKPNKSYPNLLLSNKATLQPDEYYVWSYNPKSIYDYLTVIGIIVGVLAFVCYPLWPPYMKRGTYYLSIAALALIGVFFGIAIVRLIVYLLSLAAVSEKGGFWLFPNLFEDCGVIESFKPLYGFGEKECYSFLKKEKRKHRSVAKKQK
What is the function of this protein?
Required for preprotein translocation.
What are the official names of this protein?
Translocation protein SEC62.
What is the protein family that this protein belongs to?
Belongs to the SEC62 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YCEH_ESCF3
Sequence: MKYELTAREARVIGCLLEKQVTTPEQYPLSLNGVVTACNQKTNREPVMNLSEQEVQTELDNLVKRHFLRTVSGFGNRVTKYEQRFCNSEFGDLKLSPAEVALITTLLLRGAQTPGELRSRAARMYEFSDMSEVDSTLEKLAQREDGPFVVRLAREPGKRESRYMHLFCGEVDDTASFAEETPPVAGELQARVEALENEVAELKQRLDSLLAHLGD
What are the official names of this protein?
UPF0502 protein YceH.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: Y842_STAA3
Sequence: MNPIVEFCLSNMAKGGDYVFNQLENDPDVDVLEYGCLTHCGICSAGLYALVNGDIVEGDSPEELLQNIYAHIKETWIF
What are the official names of this protein?
UPF0349 protein SAUSA300_0842.
What is the protein family that this protein belongs to?
Belongs to the UPF0349 family.
Protein: PHYDA_ECO55
Sequence: MRVLIKNGTVVNADGQAKQDLLIESGIVRQLGNNISPQLPYEEIDATGCYVFPGGVDVHTHFNIDVGIARSCDDFFTGTRAAACGGTTTIIDHMGFGPNGCRLRHQLEVYRGYAAHKAVIDYSFHGVIQHINHAILDEIPMMVEEGLSSFKLYLTYQYKLNDDEVLQALRRLHESGALTTVHPENDAAIASKRAEFIAAGLTAPRYHALSRPLECEAEAIARMINLAQIAGNAPLYIVHLSNGLGLDYLRLARANHQPVWVETCPQYLLLDERSYDTEDGMKFILSPPLRNIREQDKLWCGISDGAIDVVATDHCTFSMAQRLQISKGDFSRCPNGLPGVENRMQLLFSSGVMTGRITPERFVELTSAMPARLFGLWPQKGLLAPGSDGDVVIIDPRQSQQIQHRHLHDNADYSPWEGFTCQGAIVRTLSRGETIFCDGTFTGKAGRGRFLRRKPFVPPVL
What is the function of this protein?
Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position.  Has no activity on dihydropyrimidines.  The physiological function is unknown.
What are the official names of this protein?
D-phenylhydantoinase, Hydantoin-utilizing enzyme HyuA.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Protein: RSMC_ALIF1
Sequence: MSYSAPSQITQRQLAYFEGKHVLIAGELIDDFPFELAKHCESTSIFTTNYSYYKQFAGHNSIQCYFGSELTEPTNVDMILLYWPKAKAEAEYLLTMLLAKLGKNTEIVVVGENRSGVKSIEKMFADFGPINKFDSARRCSFYWGQCTEEAPTFNQQDWFKEYQVEFENHTIEVRSLPGVFSHGEFDKGSELLLQTLPALRGHVLDFGCGAGVIGSVMKTINPKIHLDMVDISALAIASSIETLKANNLEGNVFASDVYSDTKENYQFIVSNPPFHAGLKTHYSSTEELLEKAPQNLTHEGQLILVANSFLQYPPIIEKAFGECLTLAKNNKFKIYSAQK
What is the function of this protein?
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase C, 16S rRNA m2G1207 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RsmC.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_BORGP
Sequence: MKEDRIVFIFGPTAVGKSNILFHFPKNKAEIINVDSIQVYKEFNIASSKPSKNLMKHIKHHLVDFLDPEKEYTLGIFYEQALRIVKEIRQKKKIPIFVGGTAFYFKHLKDGFPSTPLVTSEIRIYVNNLLYLKGKSYLLKELKNVDPIRFNMLNKNDIYRIKRSLEVYYQTGIPISQFEKKQNSEFKNILIIGLKRSFEDLKTRISIRINEMLNSGLLSEIKGLFSKGYNENTPAFKGIGYNEFLLWKSRPCYSLNDIISLINKNSFLYAKRQMTFFAKISNVLWFHPEDDLVSILNLIFNVDKEI
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: RL31_GLUDA
Sequence: MKSGIHPDYHEINVIMTDGTEYKTRSCYAQPGATLRLDIDPKSHPAWTGVQRMLDTGGQVAKFNKKFGGLGRRAKA
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.