PharMolix/UniProtQA huggingface dataset:
Protein: COXM2_YEAST
Sequence: MHPQLEAERFHSCLDFINALDKCHQKEYYKRIFGLCNNEKDALNKCLKEASLNNKKRAVIESRIKRADVEKRWKKIEEEEYGEDAILKTILDRQYAKKKQESDNDANSK
What is the function of this protein?
Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.  May be involved in copper trafficking and distribution to mitochondrial COX and SOD1.
What are the official names of this protein?
COX assembly mitochondrial protein 2, Cx9C motif-containing protein 2, Mitochondrial metallochaperone-like protein CMC2.
What is the protein family that this protein belongs to?
Belongs to the CMC family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Mitochondrion intermembrane space. Note=Imported into the mitochondria via the mitochondrial MIA40-ERV1 machinery.
Protein: MENH_ECO8A
Sequence: MILHAQAKHGKPGLPWLVFLHGFSGDCHEWQEVGEAFADYSRLYVDLPGHGGSAAISVDGFDDVTDLLRKTLVSYNILEFWLVGYSLGGRVAMMAACQGLAGLCGVIVEGGHPGLQNAEQRAERQRSDRQWAQRFCTEPLTAVFADWYQQPVFASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRANLSARTFAFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVIASLAQILRF
What is the function of this protein?
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
What are the official names of this protein?
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, SHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MenH family.
Protein: BRD9_XENTR
Sequence: MGKKHKKHKSEWRSYDAGELGSPGDQSQYYVDKPLEKPLKLVLKVGGSEVTELSGSGHDSSFYEDRSDHERERHKEKKKKKKKKSEKEKDKYLDEDERRRRKEEKKRKREKEQCDSEGETEVFESVRKVDIEATDRPVRACRTHPAENESTPLQQLLEYFLRQLQRKDPNGFFAFPVTDQIAPGYFMIIKNPMDFSTMKEKISQNEYKSVTEFKADFKLMCDNAMTYNRPETVYYKLAKKLLHTGFKMMSKQAALLGDEDTTTEEPTPEIIMPTAAEVVKKSKKPSKDMFRVMEEDQSSIFEPEGNACSLTDSTAEEHVLALVEHAADEARDKINRYLPNCRIGYLKKNADGTLIYTVVNGDPENEEEDTHLVDLSSLSSKLLPSFTTLGFKEDRRHKVTFLNSTGTALSLQNNTLFTNLKPDQIDLMYAGYGDDTGIQCALSLQEFVKDCGSFAKRMVNDLLDQITGGDHSRTIYQMAGSEREGSSNSVLDYMALKTYSDVSLDMSMLSSLDKVKKELEHEDSHLNLDDASKLLPDFHDVHNDRGGSRPSSSSSVSNNSERDHHLGSPSRISVGEQQDIHDPYEFLQSPETENQN
What is the function of this protein?
Plays a role in chromatin remodeling and regulation of transcription.  Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated.
What are the official names of this protein?
Bromodomain-containing protein 9.
Protein: PYRE_NITMU
Sequence: MSDFRKEFIEFAIGRNVLCFGEFQTKAGRISPYFFNAGLFNDGESLGKLGQFYAKAILAAQLPFDMLFGPAYKGIPLVSSIAIALADGGNNYPFCFNRKEAKDHGEGGNLVGAPLAGRVLIVDDVISAGTSVRESVEYIHAAGATPAGVAIALDRMERGKGELSAVQEVRCMYGIPVTSIVNLENIVDYLREQGNLAHHLPAVEEYRARYSSRMVEPIECGGGTPRAG
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: FMNL1_HUMAN
Sequence: MGNAAGSAEQPAGPAAPPPKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAYIQKLKSYVDTGGVSRKVAADWMSNLGFKRRVQESTQVLRELETSLRTNHIGWVQEFLNEENRGLDVLLEYLAFAQCSVTYDMESTDNGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGPSRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDEKVLQELDMSDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIEDIITVIKTVPFTARTGKRTSRLLCEASLGEEMPL
What is the function of this protein?
May play a role in the control of cell motility and survival of macrophages (By similarity).  Plays a role in the regulation of cell morphology and cytoskeletal organization.  Required in the cortical actin filament dynamics and cell shape.
What are the official names of this protein?
Formin-like protein 1, CLL-associated antigen KW-13, Leukocyte formin.
What is the protein family that this protein belongs to?
Belongs to the formin homology family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Note=Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity). SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cell cortex. Cell projection, bleb. Note=Colocalized with F-actin in bleb protrusions.
Protein: FA72C_HUMAN
Sequence: MSTNICSFKDRCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFSTDIPPTNAVDFTGRCYFTKICKCKLKDIACLKCGNIVVYHVIVPCSSCLLSCNNRHFWMFHSQAVYDINRLDSTGVNVLLRGNLPEIEESTDEDVLNISAEECIR
What are the official names of this protein?
Protein FAM72C.
What is the protein family that this protein belongs to?
Belongs to the FAM72 family.
Protein: MAEL_DROYA
Sequence: MAPKKHSGFMMFVNEWRNHNAEGRRMTLAQAVSHCGTIWEKMTTQQRGPYNSGAKDADVADRGKRERLNCYGQGIAQVDLAHKEAAESLMHMKRTTERLVINAKKSYDLENAKFVFATFNYFTKALTTDVYVPAEFAACEYSLKEGVRSIYSTMIDPGQIIFGQGSDALHHSSTTHDLPLPPNALGEKNMAKLYRNIVCYLTKCQGADKPLIVFTPTENIAMVNSCFRYLECEDDSGDGGRKIQVFDIQYLLFILKKAVMDVAGLNDEKINKFVTDAFFKKDFFEFTSGIACQYHEDNDRTKYCTQSMVTRWAYTFSDFMCGDLAITVQPGKHIPAETKPNYRIICSDASSLAHESSFESFYSCPGSRVKKETQSEDFSLSSSQISVASRSYTPTDHTSFTTDLTKVCEFPSLGMRKSSKHTGPSVSTQRERNAGAWNLPAHSRSIQKYSDNDFSVTDSVRKLKN
What is the function of this protein?
Involved both in the piRNA and miRNA metabolic processes.  As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity.  Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons.  As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam).  Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage (By similarity).
What are the official names of this protein?
Protein maelstrom.
What is the protein family that this protein belongs to?
Belongs to the maelstrom family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Protein: NEF_HV2ST
Sequence: MGASGSKKRSEPSRGLRERLLQTPGEASGGHWDKLGGEYLQSQEGSGRGQKSPSCEGRRYQQGDFMNTPWRAPAEGEKGSYKQQNMDDVDSDDDDLVGVPVTPRVPLREMTYRLARDMSHLIKEKGGLEGLYYSDRRRRVLDIYLEKEEGIIGDWQNYTHGPGVRYPKFFGWLWKLVPVDVPQEGDDSETHCLVHPAQTSRFDDPHGETLVWRFDPTLAFSYEAFIRYPEEFGYKSGLPEDEWKARLKARGIPFS
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Associates with the inner plasma membrane through its N-terminal domain.
Protein: Y031_METPE
Sequence: MVQDRLFQKAISVLLIAGYEVSERCAIRPRSFDLIAEKGGLLLIIKVSSPIDNVSEEIARDLDLIAGHLEGSPLIIGGRARDTDLERGAVYLRYGIIAINPETLYDYLVDGIPPLVYASPGGLYVNINGDVLRGLREQRNMSLGDLGAVLGVSRRTISKYESGMGTTLEIAIKIEEVFDSGVIESIDLLKYTSHFANKPQERLPVQALAVLERIGLELHALRRAPFQALATFEGEMILTGYGTAQKVVKRAGLIGNLSAITHTHAMCVAIDGSIRKKVGQTLIIGEEELHDIEDGEELIELFD
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein Mpal_0031.
Protein: VPS62_YEAST
Sequence: MRISKNSHKRQRTRLYFLVTFIIYSIIPCRAVLVPWLDDDPFEATLLEMGDEPWSKDILSSTPPLHPSEVTEDNKSLKQRGNVPQYVIDNSPLLHLYSEEKYWPADVKDFVKRFQLRDHSGEKIINEHLRDLSDLQEYYSVELENGTWGRVSSEGTYMTSLDDFDKGPDWLLGEQPEYGTGHIKKAPAVLFVVDKGNGWVDAFWFYFYPFNWGPYIMGSGPWGNHVGDWEHSLVRFYKGEPQYLWMSAHGGGSAYKFEAIEKIKRLRRVDGKLTNEVIKKPLIFSARGTHAHYASVGQHAHDVPFFFMPLSDFTDRGPLWDPSLNYYAYTVTVGEKMTPCGAEETKMGLEWLSFKGAWGDKQLRPRDPRQKWCPFQWKYIDGPKGPLFKNMERVSLCQRFKWWNFWKGCPARRYIKRGEGLDAEKNDLVGDNCGILLYNIRPKWLRSILRFLTWRGSVCFIMDYFTG
What is the function of this protein?
Involved in vacuolar protein sorting.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 62.
What is the protein family that this protein belongs to?
Belongs to the VPS62 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: MATK_CHLSC
Sequence: MEELQRYLEIDRSRQQHFLYPLLFQEYIYVLAHDHGLNGSILYESMENLGYDNKSSSLIIKRLIIRMHQQNHLMISVNHSNQNRFLGYNKNFDYQMISEGFAVIVEIPFSLQLVSSLEEKEIAKFHNLRSIHSILPFLEDKFSHLNYVSDILIPYPTHLEILVQTLHRWIQDAPSLHLLRFFLHEYTNWNSFITPKKSIYLFTKDFTKENQRLFLFLYNSHVYECESVFIFLRKQSSYLGSKYSGAFIERTHFYGKMEYLVVVLRNDFQKTLWLFKDPFMHYVRYQGKAILASKGAHLLMKKWKYHLVNFWQCHFYLWYQPDRIHINQLSNHSFYFLGYLSSVLLNLSAVRSQMLENSFLINTAIKKFDTIVPIIPLIGALAKAKFCNISGHPISKPVRVDSSDSDIIDRFGRICRNLSHYHSGSSKKQSLYRIKYILRFSCARTLARKHKSTVRTFLKRLGSELLEEFLTEKEQVISLIFAINSSPSHRSYRERIWYLDILCINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IF1_HAEIN
Sequence: MAKEDCIEMQGTILETLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVEMTPYDLSKGRIIFRSR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_METPP
Sequence: MARVCQVTGKGPMVGNNVSHANNKTKRRFLPNLQYRRFWLETENRWVRLRVTNAALRLIDKVGIEQVVSDLRAKGEL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: EX7L_LIMRJ
Sequence: MDRSQYLTVSELTKYLKMKFDRDPYLHTVYLTGELSNFRLRQKHQYFSLKDDNAVIDAVMFEHQFRKIKFTPEQGMKVCVVGHVSLYEKSGRYQIYIDRMEPDGLGSLYLAFEQLKKKLSAEGLFNLPKKQIPMFPKRIAVVTSIDGAVIRDINTTVRRRYPIAQVVLYPTVVQGDKAAADIARQINRANDRGDFDTLIIGRGGGSMEDLWPFNEEVVARAIANSKIPVISSVGHETDTTIADLVADQRAATPTAAAELATPVKLNDALMTLKDDQNRLLNTMRTKINFDRQQLNKQLQSYIFQQPTRLYENYAQKVDQLTQQLGQAAQNKMQELQMNVERLSGRLTAASPLHRVQQQEQLVDQLKKQLVTASLASQNEKKQQVTTLIKQLDSLSPLKIMSRGYTYVTSDEKVVNHASQLTVGQNVHLHFDDGEVQAEIKKVKEH
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEP4_VIBVU
Sequence: MDALQYYPWLYIGLASLFGLLVGSFLNVVIYRLPKIMELEWRQECAESFPEYNITPPTETLTLSTPRSSCPSCHTPIRVRDNIPVFSWLALRGKCHHCQTKISARYPFVEALSAFLCGLVAWKFGYAPITVALIGFTLVLIAATFIDLDTMLLPDQLTLPLTWTGIALALLEISPVSLQDSVFGAMAGYLCLWSVYHLFRLLTGKEGMGYGDFKLLAALGAWLGWQYLPMIILLSSVVGLIFGLIQLRLQKQGIEMAFPFGPYLAIAGWVALMWGDSLMSWYLNYLIGA
What is the function of this protein?
Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.
What are the official names of this protein?
Prepilin leader peptidase/N-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the peptidase A24 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNME_RUEST
Sequence: METIFALATAQGKAGVAVIRVSGPHAIEIGEKLTRRTLPARGMIFSKLKDSAGEILDEALVLSFTSPDSFTGENIVEFQLHGSIAVVSAVMSAIEETGVARLADPGEFTRRALDNGKLDLTQVEGLADLIDAETEAQRKQAQVILAGTLGDLADRWRTDLIRAASLIEVTIDFADEEVPVDVTPEVKQLLSGVLHDIEKEVDGVAIAERIREGFEVAIVGSPNVGKSTLLNALAGRTAAITSEYAGTTRDVIEVRMDLAGLPVTLLDTAGLRETDDHVEGIGIRLAQERAERADIRVFLAEEDESFSIQMREGDLRLLPKADERRSAKGAISGRTGQGVDDLVSRISDTLRNRTAHDGIATRARHRETMNRAVLSLRQAIEVVEQGPEFYDLAAEDMRSAIRALELLVGRINVENLLDEIFSSFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RABG1_ARATH
Sequence: MEKTKLKIILLGDSGVGKTSLLKRYNDKDFKQLHNSTIYVDLVTKEICIAERQVILQIWDTAGQERFKSLPSRFYRDTDCCVLVYDVNTLKTFESIDNWHDEFIKQANPETPTKFPFVLMGNKTDVNNGKPRVVAKEIADQWCGSKGNIVYFETSAKAKINVEEAFLEIAKKALTNERQIDDMERYRSVVPTIEKETPRSRCSC
What is the function of this protein?
Intracellular vesicle trafficking and protein transport.
What are the official names of this protein?
Ras-related protein RABG1, AtRABG1, Ras-related protein Rab78, AtRab78.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RNT_BLOFL
Sequence: MIDPVNIDTLKARFRGFYPVVIDVETSGLNASTNALLEIATITLKMNEDGWLHVDNMLHFHIKSFPGAILQPEALALNKINPNSPLRFAVTEQEALVEIFKMVHVGIKAQQCNKAIIVAHNASFDHSFLMAATERTNNIQDNPFHPFVTFDTAALSGLVFGQTVLSKACEYAGIIFDKNKAHSALYDAEKTAILFCTLVNAWKKLGGWPWKPSLITNNEGYHK
What is the function of this protein?
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang.  Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A).  Also appears to be involved in tRNA biosynthesis.
What are the official names of this protein?
Ribonuclease T, Exoribonuclease T, RNase T.
What is the protein family that this protein belongs to?
Belongs to the RNase T family.
Protein: RL331_MYCGE
Sequence: MAVKRSTRLGCNECSEINYLTFKNVKKNPEKLALNKFCSRCRKVVLHKEVKRK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: DEF_FLAJ1
Sequence: MILPIVGYGDPVLRKVGTAITPDYPNLKETIANMYETMYNAYGVGLAAPQVGLPIRIFVIDTTPFSDDEDLPADEQKDLKGFKRTFINAKIVKEEGEEWSFNEGCLSIPDVREDVYRKPTVTIEYCEEDFVMKTEVFDGLIARVIQHEYDHIEGVLFTDKISSLKKRLIQKKLKNITEGKTFQEYRMKFAAAKKGR
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: DEN6A_CHICK
Sequence: MALWERGAGGAAEAGEDATEEPERGLPLLPWDRFSAWLHCVCVVGFDLELGQAVEVIYPPHSKLTDKEKTNICYLSFPDSNSGCLGDTQFCFRFRRSSGRKASLCCFLDHLDRDLPVYLKKDPAYYYGYVYFRQVRDKSLKRGYFQKSLVLISKLPYIHLFRTVLKQIAPEYFEKSEAFLEAVCSDVDRWPPPVPGEVLHLPIMGVVMKLRIPTYRDKPGTTPVVQNMHQADAQISMTLPTVHEVDLFRCFCPVFFHIQMLWELVLLGEPLVVMAPSPAESSETVLALVSCISPLKYCSDFRPYFTIHDSEFKEYTTRTQAPPSVILGVTNPFFAKTLQHWPHIIRIGDMKLPGDVPKQVKVKKLKNLKTLDSKPGVYTSYKPYLDKDEEIVKQLQKGVQQKRPTEAQSAILRRYFLELTESFIIPLERYVASLMPLQKCISPWKSPPQLRHFSQDDFMKTLEKAGPQLTSGLKGDWIGLYRHFLKSPNFDGWFRSRQKEMTQNLEALHLEALCNENLVFWSQKHTEVETVDLVLKLKNKLLQADREHLPVKTDTLKKLQTHIRDIILALPDDLQDILLKTGTA
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) for RAB14.
What are the official names of this protein?
Protein DENND6A, DENN domain-containing protein 6A.
What is the protein family that this protein belongs to?
Belongs to the DENND6 family.
What are the subcellular locations of this protein?
Recycling endosome. Cytoplasm.
Protein: RIMM_THET8
Sequence: MRLVEIGRFGAPYALKGGLRFRGEPVVLHLERVYVEGHGWRAIEDLYRVGEELVVHLAGVTDRTLAEALVGLRVYAEVADLPPLEEGRYYYFALIGLPVYVEGRQVGEVVDILDAGAQDVLIIRGVGERLRDRAERLVPLQAPYVRVEEGSIHVDPIPGLFD
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ST1C4_MACFA
Sequence: TALHKMEDFTFDGTKRLSVNYVKGILQPTVTCDIWDEIWNFQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPTHQRFPFLEWKIPSLGSGLEQAQAMPSPRILKTHLPFHLLPPSFLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPDPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEVQKLTEFIEKKLDDKVLDKIVHYTSFDVMKQNSMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMADTRLTFHFQF
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds and estrogen (E2) (PubMed:31100221).  Can also sulfonate estrogenic compounds, however, the dietary flavonoids (phytoestrogen) and environmental estrogens, like bisphenol A are better substrates than 17beta-estradiol (E2) (By similarity).
What are the official names of this protein?
Sulfotransferase 1C4, ST1C4.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RFC3_BLAAD
Sequence: MDKGKKVETVEKQENSLPWVEKYRPTTLDEVAGHEGVITTIKKFVEEGKLPHLLFHGPPGTGKTTTIIAVARQIYGKNYRNMILELNASDERGIDVVRDQIKTFASTRQIFSSGFKLVILDEADAMTNAAQNALRRIIEKYSAHTRFCILANYTHKLNPALLSRCTRFRFSPLKEDAIKHRLAHVIEQESVDLSPEAFQSLLHLSSGDMRRALNVLQACYASVDAGEQISEELVYDCVGSPRPADIRTVLQAVLDGSWESALHTFSYIKQSKGLALADMLTAFAVEFQKLDLQNKTRIALLDGLSEIEWRLSSGGNESIQTSATIGVIKQSMELEASS
What is the function of this protein?
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.  Subunit 3 binds ATP (By similarity).
What are the official names of this protein?
Replication factor C subunit 3, Replication factor C3, Activator 1 subunit 3.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family.
What are the subcellular locations of this protein?
Nucleus.
Protein: 14331_ARATH
Sequence: MATPGASSARDEFVYMAKLAEQAERYEEMVEFMEKVAKAVDKDELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNDDHVSLIRDYRSKIETELSDICDGILKLLDTILVPAAASGDSKVFYLKMKGDYHRYLAEFKSGQERKDAAEHTLTAYKAAQDIANSELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQDDVADDIKEAAPAAAKPADEQQS
What is the function of this protein?
Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.  Involved in the regulation of nutrient metabolism (PubMed:22104211).
What are the official names of this protein?
14-3-3-like protein GF14 chi, General regulatory factor 1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocates from the cytosol to the nucleus when phosphorylated.
Protein: SWI5_HUMAN
Sequence: MQRRGQRDLWRHNKSCARNRCPRPPRERGGAGFPWVRAQLSVRQFTLRVRVPGPVHLRGRSPTPALDPLAPLNPLIRGPRTPGLRRWIQSLALLLPNCSSSRIPTVPRPHSGLWVQSDFPLGFLSRTEPRLTRSCRGAFRSPRPLPKSGQADGTSEESLHLDIQKLKEKRDMLDKEISQFVSEGYSVDELEDHITQLHEYNDIKDVGQMLMGKLAVIRGVTTKELYPEFGLDMND
What is the function of this protein?
Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.
What are the official names of this protein?
DNA repair protein SWI5 homolog, HBV DNAPTP1-transactivated protein A, Protein SAE3 homolog.
What is the protein family that this protein belongs to?
Belongs to the SWI5/SAE3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CA131_HUMAN
Sequence: MRVDSSADPTMSQEQGPGSSTPPSSPTLLDALLQNLYDFGGTEGETEQKKIIKKRENKKRDVMASAALAAEPSPLPGSLIRGQRKSASSFFKELREERHCAPSGTPTGPEILAAAVPPSSLKNNREQVEVVEFHSNKKRKLTPDHNKNTKQANPSVLERDVDTQEFNLEKARLEVHRFGITGYGKGKERILEQERAIMLGAKPPKKSYVNYKVLQEQIKEKKAAKEEEKRLAQETDIFKKKKRKGQEDRKSKKKSAPSILSNGRIGQVGKFKNGTLILSPVDIKKINSSRVAK
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Prevents helicase DHX37 to be recruited before post-A1 state.
What are the official names of this protein?
Uncharacterized protein C1orf131.
What are the subcellular locations of this protein?
Chromosome.
Protein: PPNP_ACIBC
Sequence: MSSTQFDHVTVIKKSNVYFGGACISHTVQFEDGTKKTLGVILPTEQPLTFETHVPERMEIISGECRVKIADSNESELFRAGQSFYVPGNSVFKIETDEVLDYVCHLEG
What is the function of this protein?
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases.  Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates.  Also catalyzes the reverse reactions.
What are the official names of this protein?
Pyrimidine/purine nucleoside phosphorylase, Adenosine phosphorylase, Cytidine phosphorylase, Guanosine phosphorylase, Inosine phosphorylase, Thymidine phosphorylase, Uridine phosphorylase, Xanthosine phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the nucleoside phosphorylase PpnP family.