PharMolix/UniProtQA huggingface dataset:
Protein: PIGY_BOVIN
Sequence: MFLSLPMLTVLIPLVSLAGLFYSASVEDDFPQGCTSTTSLCFYSLLLPITIPVYVFFHLWTWMGIKLFRHN
What is the function of this protein?
Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.  May act by regulating the catalytic subunit PIGA.
What are the official names of this protein?
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y, Phosphatidylinositol-glycan biosynthesis class Y protein, PIG-Y.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: NUD18_DANRE
Sequence: MDSQSSILEENLEKILRGEGLEFDSVAEQVDPVTLRKNVCYIVGAVIFNSKEEVLMVQEAKRECYGRWYLPAGRMEECESILEALQREVREEAGIDCQPITLLLVQEQGPRWVRFIFLAEETGGSLKTTAEADDESLQAHWWDRKSPLPLRAHDILSLIDAGLKYRRNPWFPVTQPVDFPCHVVCQRLFLTFISSRADADDRLWLLMSNNNTSHHPRLPIVVSFRTYISKAVSKLIEDCMPSSYISVHIRGILGVQHNGRIPGKTDGICFNTLVLLENTEEGAEIGSPPSLETDCYRWQEVTNQGLKAKIIERIKDGSVLPFQSL
What is the function of this protein?
Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives.  Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates.  Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies.  Hydrolyzes also 8-OH-dADP and 2-OH-dADP.  Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity).
What are the official names of this protein?
8-oxo-dGDP phosphatase NUDT18, 2-hydroxy-dADP phosphatase, 7,8-dihydro-8-oxoguanine phosphatase, Nucleoside diphosphate-linked moiety X motif 18, Nudix motif 18.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family.
Protein: NM111_NEUCR
Sequence: MNGTSPVARSKRKEPPQYSSDGRLAKHHRTNGDIDMSSADANTPTEDFDGHYEEEPRHVLPLAPGADTAEWQATIENVVRNVVSIRFCQTCSFDTDPALTSEATGFVVDAERGYILTNRHVVGSGPFWGYCIFDNHEEVDAYPVYRDPVHDFGILKFDPKAIKYMPVAALPLRPDLARVGIEIRVVGNDAGEKLSILSGVISRLDRNAPEYGDGYSDFNTCYYQASAAASGGSSGSPVVNKDGFAVALQAGGRADGASTDYFLPLDRPLRALKCLQEGKPITRGDIQCQFVLKPFDECRRLGLTPEWEAQVRKAFPKETNMLVAEIILPEGPSHKKLEEGDVLIKVNGKLLTQFIPLEETLDSSVGQTVKLMLLRGGEEVEVEIEVGDLHQITPDRFVSVSGGSFHNLSYQQARLYGVACKGVYVCEAGGSFRFDNNENGWIIQSIDQKETPDLDTFIEVMKGIPDKARVVITYKHLRDMHTLHTTVIYVDRHWAKKMKLAVRNDKTGLWDFSNLSDALPAVAPVPRKASFIQLENTSHPAVADLVKSFVHVSVTMPVKLDGFPKNRKWGMGLVIDAEKGLVIISRAIVPYDLCDITITIADSIVVEGKVVFLHPLQNYAVIQYDPKLVDAPVRSAKLSSEMISQGASTYFIGYNRIGRIVHTATTVTEMFAVTIPANSGAPRYRAVNVDAITVDTNLSGQCGSGVLVAQDGTVQALWLTYLGERNPSSHRDEEYHLGLATPTLLPVISQLQQGITPKLRLLSCEFRAIQMSQARIMGVSEEWIQKVSLVNTAHHQLFLVTKRTYERNEPAGDHLKEGDILLTLNNQLITKISELDVMYSHDYLDAVIVRNTKELHIKLPTVAADDAETDHAISFCGAILHRPHLAVRQQISKLFSEVYVSARTRGSPAYQYGLAPTNFVTHVNGKRTPDLKSFLDAVVGIPDNTYFRLKCMTFDSVPWVVTMKKNEHYFPTTELIKDPSEPLTGWRRITYEGGKKIEGEGHEGVGVAVLGEDQGEGGEGDVDGCC
What is the function of this protein?
Nuclear serine protease which mediates apoptosis.
What are the official names of this protein?
Pro-apoptotic serine protease nma111.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NARX_MYCTO
Sequence: MTVTPRTGSRIEELLARSGRFFIPGEISADLRTVTRRGGRDGDVFYRDRWSHDKVVRSTHGVNCTGSCSWKIYVKDDIITWETQETDYPSVGPDRPEYEPRGCPRGAAFSWYTYSPTRVRHPYARGVLVEMYREAKARLGDPVAAWADIQADPRRRRRYQRARGKGGLVRVSWAEATEMIAAAHVHTISTYGPDRVAGFSPIPAMSMVSHAAGSRFVELIGGVMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDVVWQCASVLLTYPNSRQLGTAEELLAHIDGPAADLLGRTVSELRRADPLTAATRYVDTFDLRGRATLYLTYWTAGDTRNRGREMLAFAQTYRSTDVAPPRGETPDFLPVVLEFAATVDPEAGRRLLSGYRVPIAALCNALTEAALPYAHTVAAVCRTGDMMGELFWTVVPYVTMTIVAVGSWWRYRYDKFGWTTRSSQLYESRLLRIASPMFHFGILVVIVGHGIGLVIPQSWTQAAGLSEGAYHVQAVVLGSIAGITTLAGVTLLIYRRRTRGPVFMATTVNDKVMYLVLVAAIVAGLGATALGSGVVGEAYNYRETVSVWFRSVWVLQPRGDLMAEAPLYYQIHVLIGLALFALWPFTRLVHAFSAPIGYLFRPYIIYRSREELVLTRPRRRGW
What is the function of this protein?
Does not seem to have nitrate reductase activity.
What are the official names of this protein?
Nitrate reductase-like protein NarX.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the nitrate reductase gamma subunit family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VE6_HPV52
Sequence: MFEDPATRPRTLHELCEVLEESVHEIRLQCVQCKKELQRREVYKFLFTDLRIVYRDNNPYGVCIMCLRFLSKISEYRHYQYSLYGKTLEERVKKPLSEITIRCIICQTPLCPEEKERHVNANKRFHNIMGRWTGRCSECWRPRPVTQV
What is the function of this protein?
Plays a major role in the induction and maintenance of cellular transformation.  Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins.  E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation.  In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development.  The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT).  The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization.  Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis.  E6 also inhibits immune response by interacting with host IRF3 and TYK2.  These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
What are the official names of this protein?
Protein E6.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E6 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: AMT13_SOLLC
Sequence: MDSSWEASVTDSINAIYLLFSAYLVFVMQLGFAMLCAGSVRAKNAMNIMLTNVVDAVVGSLSYYLFGFAFAFGDSNPFIGASYFALKDIPSSSYDYSFFLYQWAFAIAVAGITSGSIAERTQFTAYLVFSFFLTGFVYPVVAHWLWSSNGWLSPNSTYLLFGSGAIDFAGSGVVHLVGGIAGFWGSIVEGPRVGRFDAFGNPVKMRGHNATLVVLGTLLLWFGWFGFNPGSFNKILVAYPHMADQGNWTSVGRTAVTTTLAGSTAGIVTLFGRRLLVGHWDAMDVCNGVLGGFVAITSGCSVVEPWAAILCGFCAAWVLIGLNILALKFKFDDPLEAAQLHGGCGAWGLIFTGLFAKEEFVLQAYNSGKTQIIRPSGLILGGGWGLFGAQIVELLSIVVWVSLTMGPLFYLLQKLGILRISSDEEVAGLDISSHGGYAYDASQEESNARFYGEYLRMQQQ
What is the function of this protein?
Ammonium transporter that may be involved in ammonium transport throughout the plant.
What are the official names of this protein?
Ammonium transporter 1 member 3, LeAMT1;3.
What is the protein family that this protein belongs to?
Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: NUON_SALPB
Sequence: MTITPQHLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNQEEFYLLVLIASLGGILLANANHLAALFLGIELISLPLFGLIGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGNLSFEALGKSLGDGMLHEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAVRVVLGIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQSGEMSMEAVGVYLAGYLFSSLGAFGVVSLMSSPFRGPDADSLYSYRGLFWHRPVLAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQASLWWLVAAVVVGSAIGLYYYLRVAVSLYLHAPQQPGRDAPTNWQYSAGGIVVLISALLVLVLGVWPQPLISLVQLAMPLM
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UVRB_CITK8
Sequence: MSKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQVESTIQRYTIYPKTHYVTPRERIVQAMEEIKDELVDRRRIMQENNKLLEEQRLTQRTQFDLEMMNELGYCSGIENYSRYLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMFRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRLRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDIDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSMAKAIGETERRREKQQLYNEEHGIVPQGLNKKVVDILALGQNIAKTKAKGKGKSRAAAKSGVVEMDMTPKALQQKIHELEGQMMQHAQNLEFEEAAEIRDQLHQLRELFIAAS
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_BURCM
Sequence: MQQQKIRIRLKAFDYRLIDQSAAEIVDTAKRTGAIVRGPVPLPTRIQRFDILRSPHVNKTSRDQLEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKLQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: KAT8_RAT
Sequence: MAAQGATAAVAATTSGIVGEGEPGPGENTSVEGPARSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKFEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
What is the function of this protein?
Histone acetyltransferase which may be involved in transcriptional activation.  May influence the function of ATM.  As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac.  As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.  That activity is less specific than the one of the MSL complex.  Can also acetylate TP53/p53 at 'Lys-120'.
What are the official names of this protein?
Histone acetyltransferase KAT8, Lysine acetyltransferase 8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, MYST-1.
What is the protein family that this protein belongs to?
Belongs to the MYST (SAS/MOZ) family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: VL2_HPV21
Sequence: MARAKRVKRDSATNIYRTCKQAGTCPPDVINKVESTTIADKILQYGSAGVFFGGLGISTGKGTGGTTGYVPLGEGPAVRVGNAPTVIRPALVPDTIGPSDIIPVDTLNPVEPTTSSIVPLTDSTGPDLLPGEVETIAEIHPGPTRPPPDTAVTTSTNGSSAVLEVAPEPTPPSRVRVTRTQYHNPSFQVITESTPTTGESSLADHILVTSGTGGQTIGGSTPELIELQDFPSRYSFEIEEPTPPRRTSTPIQRIQNIIRRRGGGLTNRRLVQQVNVENPLFVSRPSRLVQFQFDNPAFEEEVTQIFEQDIDTFNEPPDRDFLDIKTLGRPQYSETPAGYVRVSRLGKRGTIRTRSGTQIGSQVHFYRDLSTINTEDPIELQLLGEHSGDATIVQGPVESTFIDINVDENPLSEDFSAHSDDLLLDEANEDFSGSQLVVGGRRSTSSYTVPRFETTRSGSYYVQDTKGYYVAYPEDRDTSTDIIYPTPDLPVVIIHTFDTSGDFYLHPSLSRKFKRRRKYL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: RS11_SALAI
Sequence: MPPKARAGAAVKKVRRKERKNVAHGQAHIKSTFNNTIVSITDPTGAVISWASAGQVGFKGSRKSTPFAAQLAAEAAARRAMEHGMRKVDVFVKGPGSGRETAIRSLQAVGLEVGQISDVTPQPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: 5HT2A_BOVIN
Sequence: MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
What is the function of this protein?
G-protein coupled receptor for 5-hydroxytryptamine (serotonin).  Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD).  Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.  Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.  Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores.  Affects neural activity, perception, cognition and mood.  Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances.  Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).
What are the official names of this protein?
5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Cell projection, dendrite. Presynapse.
Protein: YQGF_PSYCK
Sequence: MVDSTLIKDSTDTSVAEPVIKPHLILALDYGVKKMGMALGNSLTETARAFDILAMNNGQPDWDNLLGIIKVWGVAKVVVGLPLNMDGSSSMLSKRAHKFARRLAHRIMEQHLPVIVSLCDERLTSVAAREIAWENGWIKHERAPIDDISACILMSTYFADPHSSIAIDAIKAD
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_CLOK5
Sequence: MKKGEMIYQGKAKKVYETDDKDKVIIYYKDDATAFNGEKKGQITDKGILNNNITSSLFELLEKNNIPTHFEKKLNDREQLCKKVDIIPLEVIVRNVAAGSMAKRLGLEEGTPLKTTVFELSYKDDSLGDPIINDYHAVAIGIATWDELKTIYDMTASINDILELFFRKLGIKLIDFKLEFGKFKDKIVLADEISPDTCRLWDAVTNEKLDKDRFRRDMGNVKEAYEEILRRISDN
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: PPDK1_ORYSJ
Sequence: MPSVSRAVCVQRASGNNGRRCRDGAAAAGRRSVVAQRARHGKPEVAIRSGSGGSARGGHCSPLRAVAAPIPTTKKRVFHFGKGKSEGNKAMKDLLGGKGANLAEMASIGLSVPPGFTVSTEACQQYQAAGKTLPAGLWEEIVEGLQWVEEYMAARLGDPARPLLLSVRSGAAVSMPGMMDTVLNLGLNDEVAAGLAAKSGDRFAYDSYRRFLDMFGNVVMDIPHALFEEKLEAMKAVKGLHNDTDLTATDLKELVAQYKDVYVEAKGEPFPSDPKKQLQLAVLAVFNSWDSPRAIKYRSINKITGLKGTAVNVQTMVFGNMGNTSGTGVLFTRNPSTGEKKLYGEFLVNAQGEDVVAGIRTPEDLDAMRDHMPEPYEELVENCKILESHYKEMMDIEFTVQENRLWMLQCRTGKRTGKGAVKIAVDMVNEGLVERRTALKMVEPGHLDQLLHPQFENPSGYKDKVIATGLPASPGAAVGQIVFTAEDAEAWHAQGKDVILVRTETSPEDVGGMHAAVGILTARGGMTSHAAVVARGWGKCCVSGCSSVRVNDASKIVVIEDKALHEGEWLSLNGSTGEVIIGKQPLCPPALSGDLETFMSWVDEVRKLKVMANADTPEDATTARQNGAEGIGLCRTEHMFFASDERIKAVRQMIMASSLELRQKALDRLLPYQRSDFEGIFRAMDGLPVTIRLLDPPLHEFLPEGHVEDMVRELCSETGAAQDDVLARVEKLSEVNPMLGFRGCRLGISYPELTEMQARAIFEAAITMTNQGIQVFPEIMVPLVGTPQELGHQVDVIRQIANKVFTDMGKTIGYKVGTMIEIPRAALVADEIAEQAEFFSFGTNDLTQMTFGYSRDDVGKFLPIYLSQGILQHDPFEVLDQRGVGELVKLATERGRKARPNLKVGICGEHGGEPLSVAFFAKAGLDYVSCSPFRVPIARLAAAQVLL
What is the function of this protein?
Formation of phosphoenolpyruvate.  The cytoplasmic isoform supports the biosynthetic processes in the nascent endosperm and provides an efficient mechanism for glycolytic ATP synthesis in oxygen depleted tissues.  May be involved in regulating the flux of carbon into starch and fatty acids of seeds and in the remobilization of nitrogen reserves in senescing leaves.
What are the official names of this protein?
Pyruvate, phosphate dikinase 1, chloroplastic, OsPPDKB, Pyruvate, orthophosphate dikinase 1.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
What are the subcellular locations of this protein?
Plastid, chloroplast. Cytoplasm. Note=Isoform 1 is targeted to the chloroplast while isoform 2 is found in the cytoplasm.
Protein: RPOZ_SACEN
Sequence: MSTPNALAAFNSSPSLNAPEGITNPPIDDLLEQVSSKYALVIYSAKRARQINDYYAQLGEGLLEYVGPLVEPGPREKPLSIALREIHAGVLEHTEGE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: KCNQ2_HUMAN
Sequence: MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSPCRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
What is the function of this protein?
Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.  Therefore, it is important in the regulation of neuronal excitability.  KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363).  As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873).  KCNQ2-KCNQ3 channel is selectively permeable to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+).  Associates with Na(+)-coupled myo-inositol symporter SLC5A3 forming a coregulatory complex that alters ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation.
What are the official names of this protein?
Potassium voltage-gated channel subfamily KQT member 2, KQT-like 2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2, Voltage-gated potassium channel subunit Kv7.2.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MILT_ONCKE
Sequence: LPSFLYAEMVGYNIL
What is the function of this protein?
Cysteine proteinase that hydrolyzes basic proteins, such as histones, salmine and clupeine but not milk casein.  Shows a preference for basic residues at P2 and P1 positions.
What are the official names of this protein?
Miltpain.
What are the subcellular locations of this protein?
Secreted.
Protein: ADS1_ARATH
Sequence: MSLSASEKEENNKKMAADKAEMGRKKRAMWERKWKRLDIVKAFASLFVHFLCLLAPFNFTWPALRVALIVYTVGGLGITVSYHRNLAHRSFKVPKWLEYFFAYCGLLAIQGDPIDWVSTHRYHHQFTDSDRDPHSPNEGFWFSHLLWLFDTGYLVEKCGRRTNVEDLKRQWYYKFLQRTVLYHILTFGFLLYYFGGLSFLTWGMGIGVAMEHHVTCLINSLCHVWGSRTWKTNDTSRNVWWLSVFSFGESWHNNHHAFESSARQGLEWWQIDISWYIVRFLEIIGLATDVKLPSESQRRRMAMVR
What is the function of this protein?
Involved in delta-9 desaturation of fatty acids (Probable) (PubMed:17156034, PubMed:15240892).  Involved in the production of very-long-chain fatty acids (VLCFAs) (PubMed:23175755).  May desaturate chloroplastic monogalactosyl diacylglycerol (MGDG) and alter chloroplast membrane fluidity, which is required to prime a cold acclimation response (PubMed:27062193).
What are the official names of this protein?
Delta-9 acyl-lipid desaturase 1.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: RECR_BRUME
Sequence: MSKRIAGPEIERLIQLLARVPGLGPRSARRAALHLIKKKEALLVPLGGAMQEAAEKVRICSCCGNVDTSDPCTICTDERRDPATLIVVEDVSDLWALERADTMNVRYHVLGGRLSPLDGIGPDDLNIKGLVERVASGAIKEVILAVNATVEGQTTAHYITDQLSNFDVRVTRLAHGVPVGGELDYLDEGTLAAALRARTTL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.