PharMolix/UniProtQA huggingface dataset:
Protein: SECB_SALHS
Sequence: MSEQNNTEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASSQLADDVYEVVLRVTVTASLGEETAFLCEVQQAGIFSISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEEHQDA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL1_HPV53
Sequence: MAVWRPSDSKVYLPPTPVSKVITTDAYVKRTTIFYHAGSSRLLTVGHPYYPISKSGKADIPKVSAFQYRVFRVRLPDPNKFGLPDTNIFNPDQERLVWACVGLEIGRGQPLGVGVSGHPLFNRLDDTESSSIAIQDTAPDSRDNVSVDPKQTQLCIIGCAPAIGEHWTKGTACRSTPTTAGDCPPLELINSPIEDGDMVDTGFGALNFKALQESKSDVPLDIVQSTCKYPDYLKMSADAYGDSMWFYLRREQLFTRHFFNRAGVIGEEIPNDLYIKGSNGRDPPPSSVYVATPSGSMITSEAQLFNKPYWLQRAQGHNNGICWNNQLFVTVVDTTRNTNMTLSATTQSMSTYNSKQIKQYVRHAEEYELQFVFQLCKISLSAEVMAYLHTMNSTLLEDWNIGLSPPVATSLEDKYRYVKSAAITCQKDQPPPEKQDPLSKYKFWEVNLQNSFSADLDQFPLGRKFLMQVGVRTKPPVSSKKRSASTTSTSAPSSKRKRK
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: SYA_NITWN
Sequence: MSGVNDIRSAFLNYFAANGHQIVPSSPLVPRNDPTLMFTNAGMVQFKNVFTGVEKRPYQRATTSQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKDRAIELAWKLVTQEFGLPKDRLTATVYIDDDGAFDLWKKIAGLPESRIIRIAGSDNFWQMGDTGPCGPCSEIFYDHGDRIPGGPPGSPEQDGDRFVEIWNLVFMQYEKLPDGSRPNLPKPSIDTGAGLERVAAVLQGKHDNYDIDLFVALIRAAADLTGADPQGPMKASLRVIADHLRASSFLIADGVLPSNEGRGYVLRRIMRRAMRHAQLLGAREPLMWRLVGVLVREMGEAFPELQRARPLIEETLRLEETRFRKTLERGLSILDEKSASLKQGDMFDGETAFTLYDTYGFPLDLTQDALRARGIGVDLASFTDAMEQQKAKARASWSGSGEAAAESIWFPLREKLGATEFLGYETEAAEGVVAALVKDGEEADTLKAGESGAIVLNQTPFYGESGGQVGDTGFLIADGVRFRVTDTQKKAGDLFVHLGTVEQGVLAPGMALALEVDHDRRSAIRANHSATHLLHEALRQVLGDHIAQRGSLVAPERLRFDFAHNKPISADELRCIEDIANDVVLENGEVTTRLMAVDDAREAGARALFGEKYGDEVRVVSMGGTDRHGAASNALGWSVELCGGTHVKRTGDIGLISVVGESAVASGVRRIEALTGHQARHHANHAIQLAKTAAGELRTSLDDMPARIASLMEERKKLERELSEARKKLAMGGAASASSGATTGVRDVGGIKLMARSVEGIEIKDLKSLADQGKKQLGSGVVALVATSGDGKASVVVGVTPDLVTRFSAVDLVRKASEVLGGKGGGGKPDMAQAGGPDGAKAGAALDAIAAAMGA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPSD1_ANGAN
Sequence: MNGTEGPNFYIPMSNITGVVRSPFEYPQYYLAEPWAYTILAAYMFTLILLGFPVNFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTVYTSMHGYFVFGETGCNLEGYFATLGGEISLWSLVVLAIERWVVVCKPMSNFRFGENHAIMGLAFTWIMANSCAMPPLFGWSRYIPEGMQCSCGVDYYTLKPEVNNESFVIYMFIVHFSVPLTIISFCYGRLVCTVKEAAAQQQESETTQRAEREVTRMVVIMVIAFLVCWVPYASVAWYIFTHQGSTFGPVFMTVPSFFAKSSAIYNPLIYICLNSQFRNCMITTLFCGKNPFQEEEGASTTASKTEASSVSSVSPA
What is the function of this protein?
Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision.  Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal.  This receptor is coupled to the activation of phospholipase C.  Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.
What are the official names of this protein?
Rhodopsin, deep-sea form.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS15_CLOK5
Sequence: MEKAVKQEIMEKYARHEGDTGSPEVQIALLTTRINHLNEHLKIHKKDHHSRRGLLMMVGKRRGLLNYLIKQDIERYRAIIKALNLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: SEPF_STRA3
Sequence: MALKDRFDKIISYFDTDDVSENEVHEVQERTSVQRDSRAATAQEASQRSHMTNSAEEEMIGSRPRTSTYNPNRQERQRVQRDNSYQQATPRIQNKDSVRQQREQVTIALKYPRKYEDAQEIVDLLIVNECVLIDFQYMLDAQARRCLDYIDGASRVLYGSLQKVGSSMFLLTPANVMVDIEEMNIPKTGQETSFDFDMKRR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: O4A15_HUMAN
Sequence: MELLTNNLKFITDPFVCRLRHLSPTPSEEHMKNKNNVTEFILLGLTQNPEGQKVLFVTFLLIYMVTIMGNLLIIVTIMASQSLGSPMYFFLASLSFIDTVYSTAFAPKMIVDLLSEKKTISFQGCMAQLFMDHLFAGAEVILLVVMAYDRYMAICKPLHELITMNRRVCVLMLLAAWIGGFLHSLVQFLFIYQLPFCGPNVIDNFLCDLYPLLKLACTNTYVTGLSMIANGGAICAVTFFTILLSYGVILHSLKTQSLEGKRKAFYTCASHVTVVILFFVPCIFLYARPNSTFPIDKSMTVVLTFITPMLNPLIYTLKNAEMKSAMRKLWSKKVSLAGKWLYHS
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 4A15, Olfactory receptor OR11-118.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AVRV_XANEU
Sequence: MCDSIRVQFRSIQKMVVKMKKFFRSLGVGGSSSSRFQHHIPEADSAPSSKASTPPASPPPDSPPSNSAFSALPTRPRKKAEALSDAVESRGHLAPPSLVSYANATLDQLRRNEPISESLRLMDIENLPHLVRSYDNRLNNLNLRSFDTPGQFLHDLSRWHKTGLPLRAVVRLDEDPRRWHRVAFDVRNHESGHTTIIALEPASAYNPDHMPGFVKMRENLTSQFGRKISFAVIEAEALKSIGGCVIFSLDYALAAYQERSTFDQWHKDLRKKGNIKGMTPESQHLNELGVYLLKGTRLLPANFYKHAHSRRTIDELEADQPGASGTDVRSGRAAVYKESLSRRLEEFQVQRDKTYSMSIEASRARKIRHALES
What is the function of this protein?
Serine/threonine-protein acetyltransferase translocated into infected cells, which mediates acetylation of serine and threonine residues of host target proteins (By similarity).  Induces a hypersensitive response (HR) in tomato cv.  Hawaii 7998 (S. lycopersicum) carrying the resistance gene (PubMed:10430949, PubMed:8274773).
What are the official names of this protein?
Serine/threonine-protein acetyltransferase AvrRxv, Avirulence protein AvrRxv, TAL effector protein AvrRxv.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase YopJ family.
What are the subcellular locations of this protein?
Secreted. Note=Probably secreted via a type III secretion system (TTSS).
Protein: RLMM_PSEU2
Sequence: MNTLFMHCRPGFEGEVCSEIADHAARLDVAGYAKARPDTACAEFICTEADGAERLMNGQRFDKLIFPRQWARGLFLELPETDRISVILAQLAAFPICGSLWLEVVDTNDGKELSNFCKKFEAPLRKALTQAGKLVDDPRKPRLLLTFKSGREVFLGLADADNSAMWPMGIPRLKFPREAPSRSTLKLEEAWHHFIPRDQWDERLSGDMTSVDLGAAPGGWTYQLVRRGMLVTAIDNGPMAESLMDTGLVQHLMADGFTYKPRQPVDWMVCDIVEKPARNAALLETWLGEGLCREAVVNLKLPMKQRYAEVRRLLDRIEEGFQARGVRVSIGCKQLYHDREEVTCHLRRLDVAKAARK
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCS1_THAPS
Sequence: MKQNIFKSIADLRFAIFILLVIAAFSVIGTVIEQDQSIETYKLNYPLTNRVFGFLSWDIILKFGLDHVYKTWWFITLILLFGISLLTCTLLQQFPSLKIARRCQFFRTTQQFCRLNISTNLKHLSFSQLLFKIKENNYSIFQQKNIIYCYKGLIGRIAPIIVHFSMIIILIGAIIGSLSGFKAQEIVPKTETFHIQNVLNNGQFTFIPKVSVRINDFWITYTKQTTITQFYSDLSILNIDGNEIDRQTIFVNSPAKYNGIDYYQTDWNIIGLRLRMQDSSIFQYPFINLPNTQEKLWLTWISTNQQLNDGLTILIDNLQGYCSVYNKVGKFIGNLELNESLKIENPITLIDILSSTGLQIKADPGILLIYLGFLFLMISTLISYITYSQIWIVQDKNKIFIGGNTTRATFEFELEFLKLIK
What is the function of this protein?
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
What are the official names of this protein?
Cytochrome c biogenesis protein Ccs1.
What is the protein family that this protein belongs to?
Belongs to the Ccs1/CcsB family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: WBPZ_PSEAE
Sequence: MRVLHFYKTYLSETVGGIEQVIFQLCESSGSWGIDNHVLTLSSDPHPPVVPFGGHVVHRARLDLQLASTGFSLSVFKQFRELAAEADVVNYHFPWPFMDLVHFLTGMNKPSVVTYHSDIIRQRVLLKLYRPLMSRFLHSVDRIVAASPNYFSTSDVLRQYREKTRVITYGLDKDGYPKPATQRLEHWREKLGPRFFLFVGVMRYYKGLHILLDALQGTDYPVVIVGAGPLQAELYAQAAALGLRNVHFLGRVDDEDKVALLQLSYAMVFPSHLRSEAFGISLLEGAMYGKPMISSEIGTGTSYINIHGETGLVVPPSQPAAFRQAMRWLWEHPQQAEEMGRNAEARYRQLFTAEEMGRRWSELYRELLEEKASSRYVKAAR
What is the function of this protein?
Non-processive alpha-1,3-D-rhamnosyltransferase (PubMed:23664878, PubMed:25845842).  Catalyzes the transfer of one D-rhamnose (D-Rha) residue from donor substrate GDP-D-Rha in alpha-1-3 linkage to both GlcNAc- and GalNAc-diphosphate-lipid acceptor substrates.  Is also able to transfer D-mannose (D-Man) to these acceptors at a lower level.  Nucleotide sugars GDP-D-Rha, GDP-Fuc, UDP-Gal, UDP-GalNAc, UDP-GlcNAc and CMP-sialic acid cannot act as donor substrates.  Only compounds with a diphosphate as the aglycone group can act as acceptor substrates.  No activity is detected with compounds containing a diphosphate mimic.  Fluorescent undecyl-anthracenyl group-containing compounds, such as GlcNAc-PO(3)-PO(3)-AnthrU and GalNAc-PO(3)-PO(3)-AnthrU, are also good acceptor substrates (PubMed:25845842).  Involved in the biosynthesis of the common polysaccharide antigen (CPA), also called A band, which is one of the two major cell surface O-antigens of the P. aeruginosa lipopolysaccharide (PubMed:9680202, PubMed:23664878, PubMed:25845842).  Involved in susceptibility to antibiotic colistin (PubMed:24474431).
What are the official names of this protein?
D-rhamnosyltransferase WbpZ, GDP-D-Man:GlcNAc-diphosphate-lipid alpha-1,3-D-mannosyltransferase, GDP-D-Man:GlcNAc/GalNAc-diphosphate-lipid alpha-1,3-D-mannosyltransferase, GDP-D-rhamnose:GlcNAc/GalNAc-diphosphate-lipid alpha-1,3-D-rhamnosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_MOOTA
Sequence: MGQPKYKRVILKISGEALAGNQGFGIDQEVITSIASQIKEVRELGVDVAIVVGGGNIWRGVKGSARGMDRATADYMGMLATVINSLALQDALENQGVDTRVQTAIEMRQIAEPYIRRRAIRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAELEADVILMAKRVDGVYDSDPEINPEAKRLKDLDYLTVLNGGLGVMDSTATSLCMDNHIPIIVFGIKEKGNILKAILGEPIGTYVGRLE
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1636_VIBVY
Sequence: MPSFDIVSEIDTVELRNAVDNSNRELSTRFDFRNVQASFELVEQTVKVSAEGDFQLKQMRDILRGHLAKRGVDANSMDAKTAEQTGKNWHQDIVFLQGIETPMAKKIVKLIKDAKLKVQASIQGDKVRVTGKKRDDLQETIAAIRTAELGQPFQFNNFRD
What are the official names of this protein?
UPF0234 protein VV1636.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: MNMG_FRAP2
Sequence: MIYNNTYDVIVVGGGHAGVEAAAASARIGAKTLLLTHNIDTIGQMSCNPAIGGIGKGHLVKEIDAMGGIMAKAIDMAGIQFRILNSRKGPAVRATRAQADRVLYKKAINSLLNDQENLDIFQDSVDDLVVENDTVCGVITKTGIIFKSKKVVLTVGTFLGGKIHIGQVSKEGGRAGDQPSNALAARLRALPFRVDRLKTGTPPRIDSRSVDFSVMDVQHGDTPTPYFSFFSKGKIEHPRQIPCYITYTNSKTHEIITNNLDKSAMYSGLIEGIGPRYCPSIEDKVVRFAEKDRHQIFVEPEGLNSIELYPNGLSTSLPFEVQCEYIRSIKGFENAFIMRPGYAIEYDFFDPRDLKPTLETKHIKNLFFAGQINGTTGYEEAGAQGLVAGINAAISIDSDKSWYPTRSNSYMGVLIDDLITKGTKEPYRMFTSRAEYRLILREDNADLRLSDKACELGLLNKQDQEIFINKKTAIDENIAIMKNTWIGPQTQKARDLEKFLDKKMTRESTLFDLLKRPELDYKKLQQIPDTNLKLEDESVIEQIEISAKYSGYIERQSKDIAKISTLESKTIPESFDYSQVKGLSNEVLQKLSEQKPTTLGEASRIPGVTPAAVSLLTIYMKKTGFIK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP35A_ARATH
Sequence: MIADGSEDEEKWLAAGAAAFKQNAFYMQRAIDSNNLKDALKYSAQMLSELRTSKLSPHKYYDLYMRAFDELRKLEIFFMEETRRGCSVIELYELVQHAGNILPRLYLLCTAGSVYIKTKEAPAKEILKDLVEMCRGIQHPLRGLFLRSYLAQISRDKLPDIGSEYEGDADTVIDAVEFVLLNFTEMNKLWVRMQHQGPAREKERREKERGELRDLVGKNLHVLSQLEGVDLDMYRDTVLPRVLEQIVNCRDEIAQYYLIDCIIQVFPDEYHLQTLDVLLGACPQLQASVDIMTVLSRLMERLSNYAALNAEVLPYFLQVEAFSKLNNAIGKVIEAQEDMPILSAVTLYSSLLKFTLHVHPDRLDYADQVLGSCVKQLSGKGKIDDTRATKELVSLLSAPLEKYNDVVTALKLTNYPLVVEYLDTETKRIMATVIVRSIMKNNTLITTAEKVEALFELIKGIINDLDEPQGLEVDEDDFQEEQNSVALLIHMLYNDDPEEMFKIVNVLKKHFLTGGPKRLKFTIPPLVVSTLKLIRRLPVEGDNPFGKEASVTATKIFQFLNQIIEALPNVPSPDLAFRLYLQCAEAADKCDEEPIAYEFFTQAYILYEEEISDSKAQVTALQLIIGTLQRMQVFGVENRDTLTHKATGYAAKLLKKPDQCRAVYACSHLFWLEDRETIQDGERVLLCLKRALKIANSAQQVANTARGSTGSVTLFIEILNKYLYFYEKGVPQITVESVESLIKLIKNEESMPSDPSAESFFATTLEFMEFQKQKEGAIGERYQAIKV
What is the function of this protein?
Plays a role in vesicular protein sorting.  Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.  Also involved in the efficient sorting of seed storage proteins (Probable).  Binds alone to endosomal membranes and is required for recruitment of VPS26 and VPS29 to membrane (PubMed:23362252).  The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane (PubMed:20086190).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 35A, Protein ZIG SUPPRESSOR 3, Vesicle protein sorting 35A.
What is the protein family that this protein belongs to?
Belongs to the VPS35 family.
What are the subcellular locations of this protein?
Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Prevacuolar compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: STX1A_HUMAN
Sequence: MKDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIVIASTVGGIFA
What is the function of this protein?
Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000).  Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane.  STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles.  The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion.  Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057).  Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity).
What are the official names of this protein?
Syntaxin-1A, Neuron-specific antigen HPC-1.
What is the protein family that this protein belongs to?
Belongs to the syntaxin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Synapse, synaptosome. Cell membrane. Note=Colocalizes with KCNB1 at the cell membrane. SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Protein: ANPRC_MOUSE
Sequence: MRSLLLFTFSACVLLARVLLAGGASSGAGDTRPGSRRRAREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWRRGDKHDSEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFQMRSNVKYPWGPLKLRLDETRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNQQEESNIGKHRELREDSIRSHFSVA
What is the function of this protein?
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP (PubMed:10377427, PubMed:17951249).  May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects (PubMed:10377427, PubMed:17951249).  May regulate diuresis, blood pressure and skeletal development (PubMed:10377427).  Does not have guanylate cyclase activity (PubMed:10377427).
What are the official names of this protein?
Atrial natriuretic peptide receptor 3, Atrial natriuretic peptide clearance receptor, Atrial natriuretic peptide receptor type C, ANP-C, ANPR-C, NPR-C, EF-2.
What is the protein family that this protein belongs to?
Belongs to the ANF receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ILVD_BRUA4
Sequence: MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWDDQVKKLDLVDAMVAAADDSYTDDQVKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLVVDLARRYYEQDDESVLPRSIASFPAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMADIDRLSRRVPVLCKVAPANNTVHMEDVHRAGGIMGILGQLDKAGLINTDLPTVHSETVAKALDHWDVTRTNSDMVHKFYSAAPGGVPTQVAFSQERRFDSVDTDREKGVIRSKEHAFSQDGGLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDTAVLGILNGKIKAGDIVLIRYEGPRGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGLVREGDIIDIDIPNRKIHLAVDDATLAERRAEQEETGWKPAETRKRKISTALKAYASMATSAAKGAVRKLPD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RODA_ECO57
Sequence: MTDNPNKKTFWDKVHLDPTMLLILLALLVYSALVIWSASGQDIGMMERKIGQIAMGLVIMVVMAQIPPRVYEGWAPYLYIICIILLVAVDAFGAISKGAQRWLDLGIVRFQPSEIAKIAVPLMVARFINRDVCPPSLKNTGIALVLIFMPTLLVAAQPDLGTSILVALSGLFVLFLSGLSWRLIGVAVVLVAAFIPILWFFLMHDYQRQRVMMLLDPESDPLGAGYHIIQSKIAIGSGGLRGKGWLHGTQSQLEFLPERHTDFIFAVLAEELGLVGILILLALYILLIMRGLWIAARAQTTFGRVMAGGLMLILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSV
What is the function of this protein?
Peptidoglycan polymerase that is essential for cell wall elongation.
What are the official names of this protein?
Peptidoglycan glycosyltransferase MrdB, PGT, Cell elongation protein RodA, Cell wall polymerase, Peptidoglycan polymerase, PG polymerase.
What is the protein family that this protein belongs to?
Belongs to the SEDS family. MrdB/RodA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNAK_SHEB2
Sequence: MGKIIGIDLGTTNSCVAVLDGGKARVLENAEGDRTTPSIIAYTDDETIVGSPAKRQAVTNPTNTFFAIKRLIGRRFKDDEVQRDVNIMPFKIIAADNGDAWVESRGNKMAPPQVSAEILKKMKKTAEDFLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAYGIDKKQGDNIVAVYDLGGGTFDISIIEIDSNDGDQTFEVLATNGDTHLGGEDFDNRLINYLADEFKKEQGLDLRKDPLAMQRLKEAAEKAKIELSSTNHTEVNLPYITADATGPKHLVIKITRAKLESLVEDLILRTLEPLKVALADADLSVTDINEVILVGGQTRMPKVQEAVTNFFGKEPRKDVNPDEAVAVGAAIQAGVLSGDVKDVLLLDVTPLSLGIETMGSVMTKLIEKNTTIPTKAQQVFSTADDNQSAVTIHVLQGERKQASANKSLGQFNLDGIEPAQRGQPQIEVMFDIDADGILHVSATDKKTGKKQNITIKASSGLSEEEVAQMVRDAEAHADEDKKFEELVQSRNQADGLVHATKKQVEEAGDALPSEDKEKIQAAMDAVDTAIKGNDKEAIEKATQNLIEASAKLMEIAQAKSQAQGGDNADAGKQANAAADDVVDAEFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: OMPA2_NEIMC
Sequence: MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNFQLQLTEPPSKSQPQVKVTKAKSRIRTKISDFGSFIGFKGSEDLGEGLKAVWQLEQDVSVAGGGATQWGNRESFVGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPDFSGFSGSVQFVPIQNSKSAYTPAHYTRQNNTDVFVPAVVGKPGSDVYYAGLNYKNGGFAGSYAFKYARHANVGRDAFELFLLGSTSDEAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDLIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF
What is the function of this protein?
Serves as a slightly cation selective porin.  Major antigen on the gonococcal cell surface and it may have pathogenic properties in addition to its porin activity.
What are the official names of this protein?
Major outer membrane protein P.IA, PIA, Protein IA, Class 1 protein.
What is the protein family that this protein belongs to?
Belongs to the Gram-negative porin family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: DEOC_PSEU2
Sequence: MNSLEPAALAQAIDHTLLAADASREQIATLCAEAREHGFYSVCVNSSQVPFAARQLAGSAVKVCAVVGFPLGAGLSASKASEAALTIAAGAQEIDMVLNIGWLKDGLFDEVRDDIAAVLQACGKVPLKVILETCLLDEAQKVRACEICRELGVAFVKTSTGFSRSGATLEDVALMRRVVGPDIGVKASGGVRDVATARAMIEAGATRLGTSSGIAIVTGAGTGAGY
What is the function of this protein?
In vitro, DERA can catalyze the aldol condensation of chloroacetaldehyde (CHAD) and acetaldehyde (ACD), yielding (S)-4-chloro-3-hydroxybutanal ((S)-CHB), which can combine with another aldehyde to form (3R,5S)-6-chloro-2,4,6-trideoxyhexapyranose (CTeHP), a key intermediate for statin drugs.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.