PharMolix/UniProtQA huggingface dataset:
Protein: IHFA_ANADE
Sequence: MTKADIIESVYEKVGFSKKEAAEIVEMVFDTIKETLERGEKIKISGFGNFIVRDKKSRVGRNPQTGEEIEISARRVLTFRPSQVLKNALNGGVSDETEGADDDDDDEEGEGDE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: TVP23_BOTFB
Sequence: MTTCCYETNEMNECSVFECTPTVVASLLVYLFGMLFIKNFVMIFIITILLLAADFYYLKNIAGRRLVGLRWWNEVDPASGDSHWVFESSDPNTKIINPTDSRFFWLALYSQPLLWVGLAFVAIFRFEFIWLTLIVIALSLTVTNTLAFSRCDKFGQASNLAGSAMYSSGIAGNIASATIGRFFSR
What is the function of this protein?
Golgi membrane protein involved in vesicular trafficking.
What are the official names of this protein?
Golgi apparatus membrane protein tvp23.
What is the protein family that this protein belongs to?
Belongs to the TVP23 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: ISPG_HISS2
Sequence: MSSFKPTINRRQSTKIYVGNVPIGGDAPIAVQSMTNTRTTDIEATVAQIKALERVGADIVRISVPTMDAAEAFKSIKQQVNIPLVADIHFDYRIALKVAEYGVDCLRINPGNIGREDRIRAVVDCAKDKNIPIRIGVNAGSLEKDLQEKYGEPTPEALLESALRHVEILDRLNFDQFKVSVKASDVFLAVESYRLLAKAIKQPLHLGITEAGGARAGAVKSAVGLGMLLAEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSHGINFIACPTCSRQEFDVIGTVNALEQRLEDIVTPMDVSIIGCVVNGPGEALISDLGVTGGNKKSGYYLDGKRQKERFDNEDLINQLEAKIRAKVAQQDPKNRII
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: NUF2_KLULA
Sequence: MSKDVFPLLELSELVTCLQSCDFSLAVEENISKPSSQYVITLYKQIIDTFMGVSPDTLLSNEALFDNSGSNDIQQNPAYTETVKVLALNKICFKFFQDIGVSDFNMMDLYKPDSLRTRRLLSAVVNYARFREERMFDCDKFMSKTEFLLNQLRSKFDDYNYLQQQINKHRNEIELREGETFETLQQQNKHLDQQISRLKGLQETLNIDYNAYKSRKQSLLHDLEKFGFELIELEFERNKLEKHSKTDFNELNLNIEKLSTLLATQQTNLNNLEQKHRKLRISMNTFQTLTHELYDVLQLISTDLQESHLREANLIDMREQLLQTDQKLNNILSSGVMVKMKILQSQLDNQKKKLHQLEGETKAKQIENSETLQLLQRQYTDEVVPDLRAAEEQVENDLANGTIKNYDYEISQLKQAFQTEIDAIDLEYSLLSSHINRYMEEMLRVMVEVTS
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
What are the official names of this protein?
Probable kinetochore protein NUF2.
What is the protein family that this protein belongs to?
Belongs to the NUF2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores.
Protein: KDGL_SHIFL
Sequence: MANNTTGFTRIIKAAGYSWKGLRAAWINEAAFRQEGVAVLLAVVIACWLDVDAITRVLLISSVMLVMIVEILNSAIEAVVDRIGSEYHELSGRAKDMGSAAVLIAIIVAVITWCILLWSHFG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid.  Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
What are the official names of this protein?
Diacylglycerol kinase, DAGK, Diglyceride kinase, DGK.
What is the protein family that this protein belongs to?
Belongs to the bacterial diacylglycerol kinase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SMU1_CAEEL
Sequence: MSSIEIESSDVIRLIEQFLKESNLHRTLAILQEETNVSLNTVDSIDGFCNEITSGNWDNVLKTVQSLKLPAKKLIDLYEHVIIELVELRELATARLVARQTDPMILLKQIDPDRFARLESLINRPYFDGQEVYGDVSKEKRRSVIAQTLSSEVHVVAPSRLLSLLGQSLKWQLHQGLLPPGTAIDLFRGKAAQKEQIEERYPTMMARSIKFSTKSYPESAVFSPDANYLVSGSKDGFIEVWNYMNGKLRKDLKYQAQDNLMMMDAAVRCISFSRDSEMLATGSIDGKIKVWKVETGDCLRRFDRAHTKGVCAVRFSKDNSHILSGGNDHVVRVHGMKSGKCLKEMRGHSSYITDVRYSDEGNHIISCSTDGSIRVWHGKSGECLSTFRVGSEDYPILNVIPIPKSDPPQMIVCNRSNTLYVVNISGQVVRTMTSGKREKGDFINCILSPKGEWAYAIAEDGVMYCFMVLSGTLETTLPVTERLPIGLAHHPHQNLIASYAEDGLLKLWTD
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the spliceosome (By similarity).  Selectively regulates alternative splicing of unc-52 exon 17 (PubMed:11438655, PubMed:15254247).  Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site (PubMed:11438655, PubMed:15254247).  In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18 (PubMed:11438655).
What are the official names of this protein?
Smu-1 suppressor of mec-8 and unc-52 protein, Smu1, Suppressor of Mec and Unc defects 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SMU1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL16_RHOPT
Sequence: MMQPKRTKFRKAHKGRIHGVASSGATLAFGQFGLKAMEPERITARQIEAARRALTRHMKRAGRVWIRVFPDLPVSKKPAEVRMGSGKGSPELWVARVKPGRVMFEIDGVNQQIAREALTLAAAKLPIKTRFVARIAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: GATA_CAMJR
Sequence: MITLKEALKYSKEELENLKKELNEKAKKEKKIGAYIEQFLDKDLSVSGEGVPVAIKDNISVKGWELTSASKILQGYIAPYDASVIVNLKANGFSPFGRCNMDEFAMGSSTASSYYGKTLNPLNFERVPGGSSGGSAAAVAGGLALASLGSDTGGSVRQPAAFCGCVGFKPSYGRVSRYGLASYSSSLDQIGVLTQNVEDAAILYDAIAGYDKMDSTSANIEFIKTAPNLNANKKLKIAVIENYVNDADSEVKNALLKTIDMLKANGHEIVYKNLLDSKFDIAAYYIIATAEASTNLSRYDGVRYGKRSENIQNLKEMYVNTRSEGFGEEVKRRILLGTFVLSSGYYDAYYIKAQKARAFIKAKYEEILQDCDLIFMPVTPTTAFKFDTQKSPIQTYLEDVYTISVNLAGLGGISVPVAKDKEGLNISAQLICKAYDEQTLLDGALSLEQMIKN
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: RISB_STRP2
Sequence: MNTYEGNLVANNIKIGIVVARFNEFITSKLLSGALDNLKRENVNEKDIEVAWVPGAFEIPLIASKMAKSKKYDAIICLGAVIRGNTSHYDYVCSEVSKGIAQISLNSEIPVMFGVLTTDTIEQAIERAGTKAGNKGSECAQGAIEMVNLIRTLDA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: REPA_BPPHS
Sequence: MVRSYYPSECHADYFDFERIEALKPAIEACGISTLSQSPMLGFHKQMDNRIKLLEEILSFRMQGVEFDNGDMYVDGHKAASDVRDEFVSVTEKLMDELAQCYNVLPQLDINNTIDHRPEGDEKWFLENEKTVTQFCRKLAAERPLKDIRDEYNYPKKKGIKDECSRLLEASTMKSRRGFAIQRLMNAMRQAHADGWFIVFDTLTLADDRLEAFYDNPNALRDYFRDIGRMVLAAEGRKANDSHADCYQYFCVPEYGTANGRLHFHAVHFMRTLPTGSVDPNFGRRVRNRRQLNSLQNTWPYGYSMPIAVRYTQDAFSRSGWLWPVDAKGEPLKATSYMAVGFYVAKYVNKKSDMDLAAKGLGAKEWNNSLKTKLSLLPKKLFRIRMSRNFGMKMLTMTNLSTECLIQLTKLGYDATPFNQILKQNAKREMRLRLGKVTVADVLAAQPVTTNLLKFMRASIKMIGVSNLQSFIASMTQKLTLSDISDESKNYLDKAGITTACLRIKSKWTAGGK
What is the function of this protein?
The A* protein binds to double-stranded DNA and prevents hydrolysis by nucleases.  Additionally, A* is an inhibitor of DNA replication and may have a role in the transition from semiconservative replicative form DNA replication to single-stranded DNA synthesis in the life cycle.
What are the official names of this protein?
Replication-associated protein A, RepA.
What is the protein family that this protein belongs to?
Belongs to the microviridae Rep protein family.
Protein: PVHT_TALVA
Sequence: MTTSTSKNAISKSSQEDLCSDTKDKGSSGGGNEANAEASKAIQGFRLVLLFVGLALSVFCLSLVCISEFISTFLFTRTYPDVFGFGRIVQSWLRPFRELRPSLIPLTTWRGSAPLTCYPRVVFSFLLESCTRSSRYGACSLRRWVFSSWDHSSAHLAPSLLLPGLCPCIVAQSVFTDRATWRWCFWINLPLGGVTAVAVFLFVRLPSPQGGATTFLGLLQKLDALGTCILMPLIICLLLALQWGGTTYAWNSWRVVLCLVLFTVLLVAWLYVQYRQGDGGALPLRIVRQRSIRSAILFTFGINGSMFIIVYYVPIWFQAVKDVTAQQSGINFLACSGSMSVAAIIAGTLVSTGEEKQHQGQWRIFNYTTLVSIATGLIWRYNPATSTAYCRAGTLVMFGFGAGSGMQMPFIAAQTVLSASDISLGSSLIILIQTMGGAVFLAVSQNLFQSKLIGLLESHPYGVEPEFILDTGASGLRSAVQHKYGTKAVETVLQAYNTALRQCFLVCIVLACLTIIADAGMEWKNVRAGKKPAKAPDAHHESKTDIK
What is the function of this protein?
MFS-type transporer; part of the gene cluster that mediates the biosynthesis of varicidin A, an antifungal natural product containing a cis-octahydrodecalin core.
What are the official names of this protein?
Varicidin biosynthesis cluster MFS-type transporer.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YCF4_ORYNI
Sequence: MNWRSEHIWIELLKGSRKRGNFFWACILFLGSLGFLAVGASSYLGKNIISVLPSQQILFFPQGVVMSFYGIAGLFISAYLWCTILWNVGSGYDRFDRKEGVVCIFRWGFPGIKRRVFLRFLMRDIQSIRIQVKEGLFPRRILYMEIRGQGAIPLTRTDEKFFTPREIEQKAAELAYFLRIPMEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: GATC_STAAE
Sequence: MTKVTREEVEHIANLARLQISPEETEEMANTLESILDFAKQNDSADTEGVEPTYHVLDLQNVLREDKAIKGIPQELALKNAKETEDGQFKVPTIMNEEDL
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RISB_CLOB1
Sequence: MKIYEGRLTAEGLKVGIIVSRFNEFITSKLLAGSIDCLKRHGAKEDNIEVCWVPGAFEIPVIAKKMASKGKYDAVICLGAVIRGATPHFDYVSSEVSKGVAHVSLDKEVPVIFGVLTTDTIEQAIERAGTKAGNKGYDAAMSAIEMSNLMKVLD
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: ASAR_ASPFN
Sequence: MILVSDNQFLHLGALAAWHDRATEHDLYDVQQLSVENFRHPPELSPFLYFTHMTMERSCTQCHQRKVRCSKTLPCSACVRLGATCRFPTTDANAHRPRRVQKITITDRIAQLERSLTILANSAGPLQGPENPNVRDTSTTLLPEPPQSPNRAQEVLVPDGASTRYINETFLSQILDKERALYKVIGTPRETEEITSGLRPEGLLASSRRPTNWSNELELSRWQSAQLWQIYRNNVDPVVKILHLPTVEPLVYATMNGEGSDDCRALLFAIYFAAVTSLSEVDAANLLGRDRRSCLLDFQARIEKVVIDAACLDAPTMLSLQALAIYIPVPSLRNRTDFYYETCLRAHRTSRSGWIMNGVLIRAAQSIGLHRDGTHFHLTPFDAEVRRRLWWQIIVLDYRAAEDHGLAVHGFGSRSDTRLPLHVNDSDLSPELRILPGPRAKWTEMSLFLLTSEIAIAFQKVYHTTVDHTDNAQRLQTVQELTAYLESTYLCHCDTNIPIQKVAWLSTRSLLSKFEFFVYQLSLNNEQSQEAVSSAAERTLISACACLEQSMELQTDDLLRGFRWLFASYNQFHCLMYVLWHLCAQPTGPHVVRVWNIVDLVFNVTENDPTRPDPGPTWKVLQHLREKAAQRRGNVAMSPPTQAHGPSDERVPESRTAEQHSGQELEGTGDGFGDLLAPPLDPSSLTEWINLSENLGMYRFEP
What is the function of this protein?
Transcription factor involved in regulation of gene cluster that mediates the biosynthesis of aspergillic acid (PubMed:29674152).
What are the official names of this protein?
C6 transcription factor asaR, Aspergillic acid biosynthesis cluster regulator.
What are the subcellular locations of this protein?
Nucleus.
Protein: U512D_DICDI
Sequence: MAIFKSISSISNSTGSMGSSIGTSNIVELTGNNNSISCFDGGYGGFNGLSGCGGSNANIINIDIDIGRRRRHRCC
What are the official names of this protein?
UPF0512 protein D.
What is the protein family that this protein belongs to?
Belongs to the UPF0512 family.
Protein: OXLA_SISCA
Sequence: MNVFFMFSLLFLAALGSCADDRNPLEECFRETDYEEFLEIAKNGLTATSNPKRVVIVGAGMSGLSAAYVLAGAGHQVTVLEASERVGGRVRTYRKEDWYANLGPMRLPTKHRIVREYIKKFGLELNEFFQENDNAWYFIKNIRKRVQEVKNNPGLLKYPVKPSETGKSAGQLYEESLRKVVEELRSTNCKYILDKYDTYSTKEYLLKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFGYEKRFDEIVGGMDQLPTSMYEAIKEKVQVHFNARVIEIQQNDREATVTYQTSANEMSSVTADYVIVCTTSRAARRIKFEPPLPPKKAHALRSVHYRSGTKIFLTCTKKFWEDEGIHGGKSTTDLPSRSIYYPNHNFTSGVGVIIAYGIGDDANFFQALDFKDCADIVINDLSLIHQLPKEDIQTFCHPSKIQRWSLDRYAMGGITTFTPYQFQHFSEALTAPFNRIYFAGEYTAQFHGWIDSTIKSGLTAARDVNRASENPSGIHLSNDNEF
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme.  Exhibits diverse biological activities, such as hemorrhage, hemolysis, edema, apoptosis of vascular endothelial cells or tumor cell lines, antibacterial and antiparasitic activities, as well as regulation of platelet aggregation.  Effects of snake L-amino oxidases on platelets are controversial, since they either induce aggregation or inhibit agonist-induced aggregation.  These different effects are probably due to different experimental conditions.
What are the official names of this protein?
L-amino-acid oxidase, LAAO, LAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PHS_RALSO
Sequence: MMPTLNDEQRKALFAELPGWSLQNDRDAIHKRFTFTDFNAAFGFMTRVALKAEQVNHHPEWFNVWNRVDITLSTHDANGLTHRDADLARFIEQAAQLTGAK
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: SPEH_THEP1
Sequence: MKSLGRHLVAEFYECDKEVLDNVQLIEQEMKQAAYESGATIVTSTFHRFLPYGVSGVVVISESHLTIHTWPEYGYAAIDLFTCGEDVDPWKAFEHLKKALKAKRVHVVEHERGRYDEIGIPEDSPHKVTV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: MDHP_YEAST
Sequence: MVKVAILGASGGVGQPLSLLLKLSPYVSELALYDIRAAEGIGKDLSHINTNSSCVGYDKDSIENTLSNAQVVLIPAGVPRKPGLTRDDLFKMNAGIVKSLVTAVGKFAPNARILVISNPVNSLVPIAVETLKKMGKFKPGNVMGVTNLDLVRAETFLVDYLMLKNPKIGQEQDKTTMHRKVTVIGGHSGETIIPIITDKSLVFQLDKQYEHFIHRVQFGGDEIVKAKQGAGSATLSMAFAGAKFAEEVLRSFHNEKPETESLSAFVYLPGLKNGKKAQQLVGDNSIEYFSLPIVLRNGSVVSIDTSVLEKLSPREEQLVNTAVKELRKNIEKGKSFILDSSKL
What are the official names of this protein?
Malate dehydrogenase, peroxisomal.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 1 family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: NQRF_NEIMB
Sequence: MEIILGIVMFTVIVLVLALMILFAKSKLVSEGDITIKVNGEKELTMPAGGKLLGALANEGIFIPSACGGGGSCGQCRVVVKSGGGDILPTELSHISKREAREGCRLSCQVNVKTDMDIEVPEEVFGVKKWECTVISNDNKATFIKELKLAIPEGEEVPFRAGGYIQIEAPPHTVAYKDFDIPKEYHEDWDKYNLWQYVSKVDEPILRAYSMASYPEEKGIIMLNVRIATPPPRVPDAPPGQMSSYIWSLKPGDKVTISGPFGEFFAKDTDAEMVFIGGGAGMAPMRSHIFDQLKRLNSKRKITFWYGARSKREMFYVEDFDQLAAEFPNFTWHVALSDPLPEDNWDGYTGFIHNVVYENHLKNHEAPEDCEFYMCGPPIMNQSVIKMLKDLGVEDENILLDDFGG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit F, Na(+)-NQR subunit F, Na(+)-translocating NQR subunit F, NQR complex subunit F, NQR-1 subunit F.
What is the protein family that this protein belongs to?
Belongs to the NqrF family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: SPT4_KLULA
Sequence: MSTDRACMLCGLVQSTAEFNRNGCPNCQSIFEEAGVSAVECTSPSFEGLVGMCKPSRSWVARWMSIDSYIPGMYAVKIDGRLPIEVTELLPHYKPRDGSQVD
What is the function of this protein?
The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing.  This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
What are the official names of this protein?
Transcription elongation factor SPT4, Chromatin elongation factor SPT4.
What is the protein family that this protein belongs to?
Belongs to the SPT4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Centromere and heterochromatin.
Protein: ENV_KORV
Sequence: MLLISNPRHLGHPMSPGNWKRLIILLSCVFGGAEMNQQHNNPHQPMTLTWQVLSQTGSVVWEKKAVEPPWTWWPSLEPDVCALVAGLESWDIPELTASASQQARPPDSNYEHAYNQITWGTLGCSYPRARTRIARSQFYVCPRDGRSLSEARRCGGLESLYCKEWGCETAGTAYWQPRSSWDLITVGQGHPTGTCERTGWCNPLKIEFTEPGKRFRNWLQGRTWGLRFYVTGHPGVQLTIRLVITSPPPVVVGPDPVLAEQGPPRKIPFLPRVPVPTLSPPASPIPTVQASPPAPSTPSPTTGDRLFGLVQGAFLALNATNPEATESCWLCLALGPPYYEGIATPGQVTYASTDSQCRWGGKGKLTLTEVSGLGLCIGKVPPTHQHLCNLTIPLNASHTHKYLLPSNRSWWACNSGLTPCLSTSVFNQSNDFCIQIQLVPRIYYHPDGTLLQAYESPHSRNKREPVSLTLAVLLGLGVAAGIGTGSTALIKGPIDLQQGLTSLQIAMDTDLRALQDSISKLEDSLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYVDHSGAVRDSMRRLKERLDKRQLEHQKNLSWYEGWFNRSPWLTTLLSALAGPLLLLLLLLTLGPCVINKLVQFINDRVSAVRILVLRHKYQTLDNEDNL
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity). SUBCELLULAR LOCATION: [R-peptide]: Host cell membrane; Peripheral membrane protein. Note=The R-peptide is membrane-associated through its palmitate.
Protein: LEUC_FLAJ1
Sequence: MSKTLFDKVWDSHVVRKIEDGPDVFFIDRHFIHEVTSPVAFLGLKSRGVNVLYPERTFATADHNTPTINQHLPVQDPLSANQLQALEDNANEYGISHWGLGHQKNGIVHVVGPENGITLPGATIVCGDSHTSTHGAFGAIAFGIGTSEVEMVLSTQCIMQPKPKKMRINVNGKLSKGVGPKDVALYIIAQLTTSGGTGYFVEYAGDVFENMTMEGRMTVCNLSIEMGARGGMIAPDQTTFDFLEGRLYAPKGEAWTKAVEYWKTLKTDADAVFDAELNIKAEDIEPMITYGTNPGMGIGITKHIPSAKEVEGGEETYKKSLAYMGFNEDDVMIGKQIDYVFLGSCTNGRIEDFRAFAEIVKGRKKAENVTAWLVPGSHVVEAQIKEEGILDILTEAGFVLRQPGCSACLAMNDDKVPAGKYAVSTSNRNFEGRQGPGSRTLLASPIMAAAAAVTGKLTDPRELF
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RS5_STRAW
Sequence: MAGPQRRGSGAGGGERRDRKGRDGGAAAAEKTAYVERVVAINRVAKVVKGGRRFSFTALVVVGDGDGTVGVGYGKAKEVPAAIAKGVEEAKKHFFKVPRIQGTIPHPITGEKAAGVVLLKPASPGTGVIAGGPVRAVLECAGVHDILSKSLGSSNAINIVHATVAALKGLQRPEEIAARRGLPLEDVAPAALLRARAGAGA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: MURC_STRPM
Sequence: MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTNGSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDTALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVKVEDLAAKIIKPSQVVTVENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDTG_ECO24
Sequence: MSPCENDTPINWKRNLIVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGIVFSITFLFSAIASPFWGGLADRKGRKLMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPMAGGLLADSYGLRPVFFITASVLILCFFVTLFCIREKFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNVAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSYVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWNSLRRRRIPQVSN
What is the function of this protein?
Confers resistance to fosfomycin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtG.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS7_PARD8
Sequence: MRKAKPKKRQILPDPVFGDVKVTRFVNHLMYDGKKNTAFEIFYSALETVKGKLPNEEKSALEIWKAALDNITPQVEVKSRRVGGATFQVPTEIRPDRKESISMKNLIIFARKRGGKTMADKLSAEIVDAFNNQGGAFKRKEDMHRMAEANRAFAHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.