PharMolix/UniProtQA huggingface dataset:
Protein: RS8_CHLMU
Sequence: MGITSDSIANLLTRIRNALMAEHLYIDIEHSKMLEAIVRILKQHGFVAHFLVKEENRKRLMRVFLRYGEDRRPVIHALKRVSKPSRRVYVSAAKIPYVFGNMGIAVLSTPQGVLEGSEARAKNVGGELLCLVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: TENA_BACSU
Sequence: MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQDSYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKAFKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWIGTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGWSDSAIKEVEECGASRHNG
What is the function of this protein?
Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.  Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP).  To a lesser extent, is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity is unlikely to be physiologically relevant.  Therefore, is involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the environment, rather than in thiamine degradation.
What are the official names of this protein?
Aminopyrimidine aminohydrolase, 4-amino-5-aminomethyl-2-methylpyrimidine hydrolase, Thiaminase II.
What is the protein family that this protein belongs to?
Belongs to the TenA family.
Protein: EX7L_ACAM1
Sequence: MTSYQPNLLVPPEVLSVKGLTDYIQTLLEDDSYLVQVWVEGEVSSAARHRSGFFFTLQDQQEAASIHCVIWNSYCDQLVIEPEVGEQILALGRIRVYPQRGQYQLMAWQLFPAGEGLRSLRYQQLRERLTREGLFDPLQKQALPTYPQTVGVVTSHQAAAWGDIKRTLKAQHPGLKVLFSPTKVQGKQAPEAIVLAIERVIKDGRAEVLIVARGGGATEDLACFNDERVVRAIAECPIPVISGIGHQRDETLADLVADVCAHTPTAAAECIPRLTDWQTDYRNCIARLYIILTRQLDVAHEHLLYQKTRLRRLQIDRQFEREQVLRSRLQNHLLHAIKHRLGQAQQHQQLLQQQLTSLDPTQVLKRGYALVQTTDQQIVRSTQQLQVDQELKVELAEGHFTARVTALQSSPQEADDER
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3725_YERPS
Sequence: MIIPWQQVDSETLDNLLEAFVLREGTDYGEHERSLTEKVADVRRQLVSGEAVLVWSELHETINIMPRGSFHAGAEEQQ
What are the official names of this protein?
UPF0270 protein YPTB3725.
What is the protein family that this protein belongs to?
Belongs to the UPF0270 family.
Protein: TM204_RAT
Sequence: MTVQKLVATAVLVALVSLILNNAAAFTPNWVYQTLEDGRKRSVGLWKSCWLVDRGKGGTSPGTRTGQVDTHDCEVLGWGSESAGFQESRGTVKLQFDMMRACNLVATAALAVGQITFILGLTGLPLMSPESQCWEEAMAAAFQLASFVLVIGLVTFYRIGPYTNLSWSCYLNIGACLLATLAAAMLIWNILHRREDCMAPRVIVISRSLTARFRRGLDNDYVESPC
What is the function of this protein?
Can influence paracellular permeability.  Appears to be involved in cell-cell interactions through adherens (By similarity).
What are the official names of this protein?
Transmembrane protein 204, Claudin-like protein 24.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Note=Co- localizes with the beta-catenin adherins.
Protein: MTSS2_MOUSE
Sequence: METAEKECGALGGLFQAIVNDMKSSYPIWEDFNSKAAKLHSQLRTTVLAAVAFLDAFQKVADMATNTRGATRDIGSALTRMCMRHRSIETKLRQFTNALLESLINPLQERIEDWKKSANQLDKDHAKEYKRARHEIKKKSSDTLKLQKKARKGKGDLQPQLDSALQDVNDMYLLLEETEKQAVRRALIEERGRFCTFITFLQPVVNGELTMLGEITHLQGIIDDLVVLTADPHKLPPASEQVIKDLKGSDYSWSYQTPPSSPSSSNSRKSSMCSLAQPATTRLSSVSSHDSGFVSQDPTYSKPPSPMPSDITSQKSSSSASSEASETCQSVSECSSPTSDWTKAGPHEQPSATTLQRRKDRVEHLRDTEPGPTGGGTVGSSGEEVPRTRMSPATIAAKHGEEVSPAASDLAMVLTRGLSLEHQKSSRDSLQYSSGYSTQTTTPSCSEDTIPSQGSDYDCYSVNGDADSEGPPEFDKSSTIPRNSNIAQNYRRLIQTKRPASTAGLPTAGLPTAMGLPSGAPPGVATIRRTPSTKPTVRRALSSAGPIPIRPPIVPVKTPTVPDSPGYVGPTRAGSEECVFYTDEVASPLAPDLAKASPKRLSLPNTAWGSQSPEVASYGGGAAVGLATEDEEQQLAANRHSLVEKLGELVAGAHALGEGQFPFPTALSATPSEETPTPPPAATSDPPAEDMLVAIRRGVRLRRTVTNDRSAPRIL
What is the function of this protein?
Involved in plasma membrane dynamics.  Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation.  May function in actin bundling.
What are the official names of this protein?
Protein MTSS 2, MTSS1-like protein.
What is the protein family that this protein belongs to?
Belongs to the MTSS family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, ruffle. Note=Colocalizes with RAC1 within membrane ruffles.
Protein: PFA3_CANGA
Sequence: MNLVNNFSKLFPRCLTTGLYLWSLYAIVVCIHVIRARVVLPLVFTIAMVALYTYAKLIYVGPGTTKEYSILRVYDLNAAESGFELPPEMLVKRSYTQKRNGRFRVCKSCSSWKPDRCHHCSTCNVCVLKMDHHCPWFAGCVGYRNQKFFIQFLIYCTVYSILVLILSSMEIYTWFKGEFFEVELINFTLLSLWLLALVVSISITIFTVFSISQVCQNQTTIELYSLRRYNEEVAFLNEFSNEPIKGTINIFDLGKKLINWEEVMGYSLIEWALPISRRPSSLDLEGSHSHGLFFNVNKNVSKTMNESVDLQDRLLRRLTPRSSLDVDRSNFV
What is the function of this protein?
Palmitoyltransferase specific for VAC8.  Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
What are the official names of this protein?
Palmitoyltransferase PFA3, Protein fatty acyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: MBSP_SAUWA
Sequence: IVGGAECVPY
What is the function of this protein?
Serine protease which degrades the myosin heavy chain but not actin or alpha-actinin.  Selectively cleaves Arg-|-Xaa bonds.
What are the official names of this protein?
Myofibril-bound serine protease, MBSP.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7A_DESA1
Sequence: MPKPFYVKFEVPPELADKVYQAISKVRETGGKIKKGTNETTKAVERGQAKLVVIAEDVDPPEIVAHLPLLCDEKKIPYVYVPSKQKLGQAAGIEVSAASVAVIDVGGAKDLIDEIIKSVQQIRAQSG
What is the function of this protein?
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
What are the official names of this protein?
50S ribosomal protein L7Ae, Ribosomal protein L8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_SHIF8
Sequence: MFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVRYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVGRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASLHPQQVPCYITHTNEKTHDVIRSNLDRSPMYAGVIEGVGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFIQGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEIGRELGLVDDERWARFNEKLENIERERQRLKSTWVTPSAEAAAEVNAHLTAPLSREASGEDLLRRPEMTYEKLTTLTPFAPALTDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQISGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRR_RAT
Sequence: MCAQYCISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVKQAERPAP
What is the function of this protein?
Catalyzes the synthesis of D-serine from L-serine.  D-serine is a key coagonist with glutamate at NMDA receptors.  Has dehydratase activity towards both L-serine and D-serine.
What are the official names of this protein?
Serine racemase, D-serine ammonia-lyase, D-serine dehydratase, L-serine ammonia-lyase, L-serine dehydratase.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family.
Protein: TRPD_GEOSW
Sequence: MFKQLLAKCIEGYTLTEEEAYEAMMMIMSGEASASQIASFLSILRLRGETVDELTGLVKAMRNRMMTLDYEEEAIDTCGTGGDGASTFNISTAAAIVVSSLGVKVAKHGNRAVSSKSGSADVLEALHIDIQATPEEAKRALKTKGLAFLFAPLYHSAMKYAALPRKEIGFRTVFNLIGPLSNPARCKRQVIGVYSTQYAEKLAETLHRLGSEHVLLVTGKDGLDECSISAETDVVELKHGEIRRFTIAPEQYGLARGKLEHVQVRTVQQSAELLKAVLEGRANESAINIVILNAGVALYAAGKAATIREGVEMAKEAMMTKKAYEQFERLRMKEVEKYA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RS13_CAMC1
Sequence: MARIAGVDLPNKKRIEYGLTYIYGIGLYKSRQILDAAGISYDKRVYELSEDEAAAIRKEIQEHHVVEGDLRKQVAMDIKALMDLGSYRGLRHRKGLPVRGQKTKTNARTRKGRRKTVGAATK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: CAST2_MOUSE
Sequence: MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSLTETPEDYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKSVIAPLADQNISVFMLSTYQTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLSFTNGFVKPKMVQRPVIHPLSSPSNRFCVTSLDPDTLPAVATLLMDVMFYSNGVKDPMAASDDCGHIRFFSFSLIEGYISLVMDVQTQQRFPSHLLFTSASGELWKMVRIGGQPLGFDECGIVAQISEPLAAADIPAYYISTFKFDHALVPEENISGVIHALKVSQAGKH
What is the function of this protein?
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex.  As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1.  Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
What are the official names of this protein?
Cytosolic arginine sensor for mTORC1 subunit 2, GATS-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the GATS family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RSMA_CHRVO
Sequence: MSKHIPRKRFGQNFLQDASVIAGIVHAVNPQPDDIVIEIGPGLGAITKPLLARLKHLHVVEIDRDIIERLKAEHPADKLTIHAGDALAFDFASVSEAPLKIVGNLPYNISTPLLFHLASYGNRVTDMHFMLQKEVIERMVAEPSTADYGRLTVMLQYRFYMENILFVPPEAFWPPPKVDSAVVRMIPAPGRCGTARDEALLEKLVSQAFAQRRKTLRNNLKGLADAADLEALGIDPGLRPENLPVEDFVRLANHLHDKGARG
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_SHEON
Sequence: MALRLEDKKAIVAEVNEAAKGALSAVAADSRGVTVGAMTGLRKKAREAGVYVRVVRNTLARRAVEGTAFECLAETFTGPTLIAFSNEHPGAAARLLKDFAKEQANFEVKGAAFEGNFIPAADIDRLAKLPTYEEALAQLMMTMKEASAGKFVRTLAALRDQKQEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ATP5L_HUMAN
Sequence: MAQFVRNLVEKTPALVNAAVTYSKPRLATFWYYAKVELVPPTPAEIPRAIQSLKKIVNSAQTGSFKQLTVKEAVLNGLVATEVLMWFYVGEIIGKRGIIGYDV
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane.
What are the official names of this protein?
ATP synthase subunit g, mitochondrial, ATPase subunit g, ATP synthase membrane subunit g.
What is the protein family that this protein belongs to?
Belongs to the ATPase g subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: DNA2_BOVIN
Sequence: MERVDELELLMEKSFWQEAEPSAELFQKKKVEASFSKIVLSRGMDNRYLVLAVDIVQSEEGNHEKHLIITASQSLEYKELCILRNDWCSVPVEPGDIIHLEGDCISNTWIIDEDFGYLILYPDMLISGTSIASSIRCMRRAVLSETFRSSDPATRQMLIGTVLHEVFQKAVSDSFAPEKLQELASQTIQEIRHLKEMYRLKLNQDEIKQEVEEYLPSFSKWAGDFMHKHTSTDFPQMQLSLPSDGSNSNSTCNIEVTNSLDIEESIWSPRFGLKGKIDVTVGVKIHRGCKTKYKIMPLELKTGKESNSIEHRSQLVLYTLLSQERRADPEAGLLLYLKTGQMYPVPAKHLDKRELLRLRNQMAFSLFHRINKSTGEKTELAPLPQIIEEQQTCKYCSQMGNCALYSRAVEQQMEDSSVPTSMWPKIKEETQHLKPIHLEYFSLWCLMLTLESQSKDNKRNYQHIWLMPASEMEESGSCIGSLIRIEHVKTVCDGQYLHNFQRKNGAIPITNLMAGDRIILSGEERTLFALSRGYVKEINSTTVTCSLDRNLSGLPESTLFRLDQEEKNCDIDTPLGNLSKLMENTRASQKLRDLIIDFREPQFISYLSSVLPHEAKDTVACILKGLNKPQRQAMKKVLLSKDYTLIVGMPGTGKTTTICTLVRILYACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQIQKVHPDIQKFTEEEICRSKSIKSLALLEELYNSQLIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVLNREARALGMSESLFKRLEQNKNAVVQLTVQYRMNSKIMSLSNKLTYEGKLECGSDKVANAVINLPNFKDVKLELEFYADYSENPWLIAAFEPNNPVCFLNTHKVPAPEQVEKGGVSNIMEAKLVVFLTSVFIKAGCKPSDIGIIAPYRQQLKVISDLLAQSSVGMVEVNTVDRYQGRDKSIVVVSFVRSNEDGTLGELLKDWRRLNVAITRAKHKLILLGCVPSLSRYPPLRKLLNHLNSEKLIIDLPSGEHESLFHLLGDFQRK
What is the function of this protein?
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion.  Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1.  Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA.  Also involved in DNA replication checkpoint independently of Okazaki fragments processing.  Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities.  While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate.  According to various reports, the helicase activity is weak and its function remains largely unclear.  Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function (By similarity).
What are the official names of this protein?
DNA replication ATP-dependent helicase/nuclease DNA2, DNA replication ATP-dependent helicase-like homolog.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: Y4SG_SINFN
Sequence: MRIAVVCNSAFTGVINRFGQPYPQPPQPWPQGRIADSVVAALQECGHETLLCEGDKGLLTTLERFMPPDPLARTSGMVFNLAEGIQGEYRFTHVPAMLEMAGVPYTGSSPLGHGLTDDKVISKTLMRDSGVPTPNFSIMRRGTESTDDLRFPVVVKPRHEDNSFGLQLVHEPAQLQQAVKMIVTKYAQDALVEEYIDGREIHVALLGNQEVEVLPMVEFELGEHEAPLLTWEAKYLAAVQPPKTCPAKIESKLATLLRDISVATFRACQCRDYARVDLRLDRSGQPFVLEINSMPGLSTHSAYVLAAMTAGHSYSSLINGILDVAHRRYFGNGILG
What is the function of this protein?
Could be involved in the biosynthesis of a cell wall component.
What are the official names of this protein?
Uncharacterized protein y4sG.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
Protein: RS19_PHOLL
Sequence: MPRSLKKGPFIDLHLLKKVEKAVESGDKKPIKTWSRRSTIFPNMIGLTIAVHNGRQHVPVFVSDEMVGHKLGEFAPTRTYRGHAADKKAKKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: M3K21_HUMAN
Sequence: MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQMKDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTESALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSLPSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAYPQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELEKEFLS
What is the function of this protein?
Negative regulator of TLR4 signaling.  Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase 21, Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Protein: GLGC_PARXL
Sequence: MDTPARLNDLQRTTLAIVLAGGRGTRLGPLTNKRVKPAVHFGGKYRIIDFALSNCLNSGIRRIAVVTQYKAHSLLRHLQRGWSFLRGEFGEFIDLWPAQQRVEGAHWYRGTADAVFQNLDIIRSIRPKYVVVLAGDHIYKMDYTRMIADHAESGADCTVGCIEVPRMDAVAFGVMHVDENRRVTGFVEKPADPPAIPGRPDTALASMGIYVFSADYLYSLLEENISSVDTDHDFGKDILPRVVTQGTAIAHPFSMSCVSSDPNVEPYWRDVGTIDAYWAANLDLASTIPTLDLYDRSWPIWTYQEQLPPAKFVRDMKGLQGSGNNLIVCGGCVISGSQISRSVLSSNVKVSSFCNINEAVLLPQVTVGASCRLQKVVIDRGCAIPDGTVIGEDPVSDAERFYRTDDGVVLVTPEALRQMPK
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: RPOC2_SILLA
Sequence: MAERANLVFHNKSIDGTAMKRLISRLIDHFGMAYTAHILDQVKTLGFQQATATSISLGIDDLLTIPSKGWLVQDAEQQSLILEKHHHYGNVHAVEKLRQSIEIWYSTSEYLRQEMNPNFRMTDPYNPVHIMSFSGARGNVSQVHQLVGMRGLMSDPQGQMIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTSDAGYLTRRLVEVVQHIVVRRTDCGTIRGISVSPRNGRMPERIFTQILIGRVLADDIYLGSRCIATRNQDIGVGLVNRFITFRTQPIAIRTPFTCRSTSWICRLCYGRSPTHGDLVELGEAVGIIAGQSIGEPGTQLTLRTFHTGGVFTGGTAEHVRAPYNGKIKFNEGLVHPTRTRHGHPAFLCYIDLYVTIESEDSLHNVNIPPKSFLLVQNDQYVESEQVIAEIRAGASTLNFKEKVRKHIYSDSEGEMHWSTDVYHAPEFTYGNVHLLPKASRLWILSGRPYRSSVVSFSLHKDQDQTTGNSLSFEQKIYNLSMTNDQVQNKFLDPYIKKSSKKEDRSPNYSELNGMSHCNHIYPAKNSDLLAKRRKNRLIIPFQFQLSQEREKELMSLSNGISIEIPINGIFRRNSIFAYFNDPRYRTKSSGITKYETIETHSSVKKEDLIEYRGVKEFRPKYQMKVDRFFFISQEVHILPGSSSIMVRNNSIIGVDTQITLNTRSRVGGVVRVERKKKKIELKIFSGDIYFPGETDKISRHSGILIPPGKTNYKESKNIKNWLYVQRITPTKKKYFVLVRPVVTYEITDGINLATLLPQDLLQERGNVQLRVFNYILYGNGKVTRGIYDTSIQLVRTCLVLNWNQDKKDSSIEEARASFVEVRTNGIIRYFLKIGLMNRALSYIGKRNNPPLFSDDGLEYTNMNPFFSIYSKPKLQQAFNPNQGTVRMLVGKNKECQSFIILSSSNCFRMGPFTLNGVKYPKESIKKDRLILIKNSFGPLGTVLNFVNFFFFYHLITHNQILVNNYLQLDNLKQTCQVLKYQYYLMDENGIIYNPDFCSNIILNPFNLHWDFLHYNFCDETSTKMRLGQFICENICIKKNGLHLKPGQIIIVQFDSVVIRSAKPCLATPGATVHGHYGEIIYEGDTLVTFIYEKSRSGDITQGLPKVEQVLEVRSVESISMNLEKRINGWNERIKKILGIPWGFLVGAELTIAQSRISLVNKIQKVYRSQGVQIHDRHIEIIVRQITSKVLVSEDGMSNIFLPGELIGLFRAERTGRALEEAICYRTILLGITRASLNTQSFISEASFQETARVLAKAALRGRIDWLKGLKENVVLGGMIPVGTGFKGFVHRSNQHKSISIPLKIKNKNRLEGEMRDILFYHRELLDSCFLKNLGDRSKQQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RUVB1_SYNJA
Sequence: MAIISSRDTGQNAEGPKRRQQKSSAWRKEGRELSFAGERGADPSALLQPQAHPGEAQEESLRPRTLAEYIGQTELKEVLSIAIAAARARQEPLDHLLFYGPPGLGKTTVAAVLAAEMGSQFYMTTAPALESPRDIAGYLVRLKRGDVLFIDEIHRLPKVTEELLYPAMEDFRLDITIGKGRSARITSLPLERFTLIGATTRIGALTSPLRDRFGHVQRLRFYEPHELVQIVLRTARLLNVSTDPEGAAEIARRSRGTPRIANRLFKRVRDYAQVRGDGHISQEVAAAALELFQVDPMGLDWIDRKLLTVLVEQFGGGPVGLETMAAVTGEDPQTIEEVYEPYLLQIGYLQRTPRGRVVTPAALRHLGYEAQSPLPLWS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB 1.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.