PharMolix/UniProtQA huggingface dataset:
Protein: MRAZ_METPP
Sequence: MAEIVFQGASALALDAKGRLAVPARHRDVLGALAQGRLTLTKHPVGCLLVFPRPAWEGFRDKVAALPLRAEGWKRIFLGNAMDVEIDASSRVLVSPELRQAAGLVKDVMLLGMGSHFELWDVQRYQAHEAEVMQQGLPESLGDFSF
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: EIF3C_ASPFC
Sequence: MSSRFFYGGGSDSDSSSSDEEELYSDREEEEKSEEEESSEEEDETSEEEESDEETGARKFLKDVASDSEEEEEEEKVTVVKSAKDKRLDELENTIKLIENAKKINDWAVISTEFDKLNRQVAKITQSGPTPKIYIKAVADLEDFVNETVAKQKSGDKKLNASQAKGFNAAKQRIKKNNKDYGNLIDKYRKDKEDFMESDDEEAIPVIAAPRITKLERIEAPAAAIDDDGFATVGRGGKTLQYTPESILKHLRVIVESRGKKNTDRMEQIRTMEKLLEVAQTPYQRIRVYLTLISTRFDLTSTSSANYMAVDQWKSAEQDFSSLLSVLENNRDHVVFEGAEEWEDDEKQPTIAPGETLYIPGSIVSFAERLDDELTRSLQHIDPHTAEYIERLSDEKLLYTDLVRAQAYVEGLNEVEKTDPRQDSVNRVVMRRLEHVYFKPSQVITILEDATWKSLPSELDSSITPRASSGNVENLVLSLCNYLFKYSDGIIRARAMLCQIYFLALHDQYYRSRDLMLMSHLTENISNFDVSTQILFNRTLVQIGLCAFRSGLIYEAQNTLSEVCGSGRQKELLAQGIIMQRYSTVSPEQERLERQRQLPFHMHINLELLECIYLTSSMFLEVPLMAQTSSSPEMKRRVISKTFRRMLDYNERQVFTGPPENTRDGVIMSAKFLAAGDWKKAAEMLNSIKIWDLMPQPDKIKEMLSQQIQEEGLRTYLFTYAPFYDSLSIATLSNMFELSEKKISAIISRMISHEELAAALDQVNNAIVFRKGVELSRLQSQIVTLADKSMNLLEANEKTLEQRTQGMANAFQRDQGAGARGGRGSGRGGQARGGPRFPGGQQGRRPGGQQFGGGALGGAIKA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A1H1_LOXSP
Sequence: WIMGHMVNAIGQIDEFVNLGANSIETDVSFDSNANPEYTYHGIPCDCGRNCKKWENFNDFLKGLRSATTPGDSKYKEKLVLVVFDLKTGSLYDNQANDAGKKLAKNLLQHYWNNGNNGGRAYIVLSIPDLNHYPLIKGFTDTLKQEGHPELLDKLGYDFSGNDAIGDVANAYKKAGVSGHVWQSDGITNCLLRGLTRVREAVANRDSGKGYINKVYYWTVDKRASTRDALDAGVDGIMTNYPDVITDVLNEAAYKSKFRVATYDDNPWETFKK
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin LspaSicTox-alphaIA1i, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AAEB_SHISS
Sequence: MGIFSIANQHIRFAVKLATAIVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGFLRIIGTFIGCIAGLVIIIAMIRAPLLMILVCCIWAGFCTWISSLVRIENSYAWGLAGYTALIIVITIQPEPLLTPQFAVERCSEIVIGIVCAIMADLLFSPRSIKQEVDRELESLLVAQYQLMQLCIKHGDGEVVDKAWGDLVRRTTALQGMRSNLNMESSRWARANRRLKAINTLSLTLITQSCETYLIQNTRPELITDTFREFFDTPVETAQDVHKQLKRLRRVIAWTGERETPVTIYSWVAAATRYQLLKRGVISNTKINATEEEILQGEPEVKVESAERHHAMVNFWRTTLSCILGTLFWLWTGWTSGSGAMVMIAVVTSLAMRLPNPRMVAIDFIYGTLAALPLGLLYFLVIIPNTQQSMLLLCISLAVLGFFLGIEVQKRRLGSMGALASTINIIVLDNPMTFHFSQFLDSALGQIVGCVLAFTVILLVRDKSRDRTGRVLLNQFVFAAVSAMTTNVARRKENHLPALYQQLFLLMNKFPGDLPKFRLALTMIIAHQRLRDAPIPVNEDLSAFHRQMRRTADHVISARSDDKRRRYFGQLLEELEIYQEKLRIWQAPPQVTEPVHRLAGMLHKYQHALTDS
What is the function of this protein?
Forms an efflux pump with AaeA.  Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
What are the official names of this protein?
p-hydroxybenzoic acid efflux pump subunit AaeB, pHBA efflux pump protein B.
What is the protein family that this protein belongs to?
Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS3_YERP3
Sequence: MGQKVHPNGIRLGIVKAWNSTWYANTKEFADNLDSDFKVRQFLTKELAKASVSRIVIERPAKSIRVTIHTARPGIVIGKKGEDVEKLRKVVADIAGVPAQINIAEVRKPELDAKLVADSITSQLERRVMFRRAMKRAVQNAMRLGAKGIKVEVSGRLGGAEIARTEWYREGRVPLHTLRADIDYNTSEAHTTYGVIGVKVWIFKGEILGGMAAVEQPEPAAQPKKQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: NXPH3_MACMU
Sequence: NATGQGNISISLVPPSKAVEXHQXQQIFIEAKASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYSTDYR
What is the function of this protein?
May be signaling molecules that resemble neuropeptides.  Ligand for alpha-neurexins (By similarity).
What are the official names of this protein?
Neurexophilin-3.
What is the protein family that this protein belongs to?
Belongs to the neurexophilin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y489_STREM
Sequence: MDPKKIARINELAKKKKTVGLTGPEKVEQAKLREEYIEGYRRSVRHHIEGIKIVDEDGNDVTPEKLRQVQREKGLHGRSLDDPES
What are the official names of this protein?
UPF0291 protein Sez_0489.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_XANCP
Sequence: MTCRTRFAPSPTGYLHIGGARTALYCWLEARHRGGQFVLRIEDTDRERSTQVAIDAILEAMEWLGLGYDEGPIYQTQRIARYQEVAEQLLAQGKAYYAYETREELDAMREAAMAKQEKPRYNGAAREQQLPYRDDPNRVIRFKNPLAGTVVFDDLIKGRIEIANSELDDMVIFRPDGYPTYNFAVVVDDWDMGITEVIRGDDHINNTPRQINIYEALGAPVPKFAHMPMILDEQGAKLSKRTGAADVMQYKDAGYLPHALINYLARLGWSHGDQELFSQQELLDLFDVKDVNSKAARLDMAKLGWVNQHYLKTDDPASIAPQLEYQLRKLGIDVAAGPAAADVVVALRERVQTLKEMAEKAVVWYQPLETYDEAAVIKHLKLGAEVPLGKAREMLAALNEWSVENVSAALHAAAAALELGMGKVAQPLRVAITGTQVSPDISQTVYLAGREGALKRIDAALIKIGAA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSB_KLEP3
Sequence: MSGWQRIYYKLLNLPLRVLVKSKSIPAEPAQELGLDTSRPVMYVLPYNSKADLLTLRAQCLAHDLPDPLEPLEIDGALLPRYVFIHGGPRVFTYYTPKEESIKLFHDYLDLHRNHPDLDVQMVPVSVMFGRSPGREKGEVNPPLRMLNGIQKFFAVSWLGRDSFVRFSPSVSLRRMADEHGTDKIIAQKLARVARMHFARQRLAAVGPRLPARQDLFNKLLASKAIARAVEDEARSKKISHEKAQQNAIALMEEIAANFSYEMIRLTDRILGFTWNRLYQGINVHNAERVRQLAHDGHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRLGAFFIRRTFKGNKLYSTVFREYLGELFSRGYSVEYFVEGGRSRTGRLLDPKTGTLSMTIQAMLRGGTRPITLVPIYIGYEHVMEVGTYAKELRGATKEKESLPQMVRGLSKLRNLGQGYVNFGEPLPLMTYLNHHVPEWREAIDPIEAIRPSWLTPTVNNIAADLMVRINNAGAANAMNLCCTALLASRQRSLTREQLTQQLECYLALLRNVPYSPDATTPSASASELIDHALQMNKFEVEKDTIGDIIILPREQAVLMTYYRNNIAHMLVIPSLLAALVTQHRQLSRTEVLRHVETLYPFLKAELFLRWEKAELAGVVDALIAEMLRQELIVVDGEVMSLNPSHSRSLQLLAAGARETLQRYAITFWLLSANPSINRSSLEKESRTVAQRLSVLHGINAPEFFDKAVFSTLVLTLRDEGYISDTGDAEPEETLKVYRMLADLITSDVRLTIESVTQDDA
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: KAD_ERYLH
Sequence: MNIILLGPPGAGKGTQSQRLVERHGMRQLSTGDMLRAAVKAQTPVGLKAKAVMDRGELVSDDIVSELIDAELTAMHGNVGAIFDGYPRTAAQAGQLDVILAKHDRSLDKVIELEVNEEALVDRITGRFTCAKCGTGYHDRHKQPAREGVCDVCGSTEFKRRPDDNEETVRTRMQEYRAKTAPILPIYEERGLVERVDGMGGIDEVTAAIDALLK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIXE_HOTJU
Sequence: MKFFLMCLIIFPIMGVLGKKNGYPLDRNGKTTECSGVNAIAPHYCNSECTKVYYAESGYCCWGACYCFGLEDDKPIGPMKDITKKYCDVQIIPS
What is the function of this protein?
Excitatory insect toxins induce a spastic paralysis.  They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.  This toxin is active only on insects.
What are the official names of this protein?
Beta-insect excitatory toxin Bj-xtrIT, Bj-xtrIT, Bjxtr-IT, BjxtrIT.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CC149_CAEEL
Sequence: MKENNNAEILELKKQFTALQQKCGAKTDTIVRLGQDLEKSENEKKGLAARVETLERNLERSERELQLVCACQNDMKIKFGTERQDLIEDIEKYKRENQQLRTDRQELLDQKADLKKDCKTFRQTIAQFEVEKMGGPVRNSFSTENDEVSKLEAHEKLQAKCKGLESDLRSMLGIKEELLMERDEMQRKVARLSNELSYLLNGDPRRVAEDLDSLVAENRFLKAKLNTAEEESESIKMTLAKYKQMAEAVNVQTMVNRSPKAGEGDDKPSVAVINMKQIRELLASHAIELVESDYRAITTILLDLCNDKQMALAHSRRANKVLGMRLHEVESKLAVLDIKSRSSSPRHELPRDEDIELVVPKAVASTSSK
What are the official names of this protein?
Coiled-coil domain-containing protein 149.
What is the protein family that this protein belongs to?
Belongs to the CCDC149 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Localizes to the base of the cilium.
Protein: VG75_EHV1V
Sequence: MSSNSDNTECFGGVNYAEGMRKRKRNPVRNSTFQEYLDARNARYPRSGSTSDSDEDYTTRSKYESDVSEFKKMMDLETLPPPKAEPQAQKAEPDAAKEEPVSTTSYILNEWVAPMIGHFLAMCMYELLFK
What are the official names of this protein?
Uncharacterized gene 75 protein.
Protein: FMQD_ASPFU
Sequence: MQYIPFLISGLVPVALSKSLFEATSNTRIDGNDIAAIFGPVLTPEAHIFLPSDGDYDDNVMARWSTFNDPSYVATVKPATETDVQAIREYQVSTAASHNITFFATGGGHGVKLNFGNVQNAINIELSLLDFIDLDLDNEVVTIGPGVENAQLYDLLSSVGKETALTGERCVNTIGPTLGGGLGPLYGIRGPQVDSLVSARLVTASGDVITVSRSENRDLFWAIRGAGANFGIVTSATYRIYDQTNGGMAVSAQFAFAPAVNRSVFDLMESMNDEYPPGMSGGMILSYNHTTNEPSVQWNLLFMGSNEDAQPWLDKIQALGPIDSSIRNVPWHRRDEPEVPYCERGQHYILYNLNLRRTDAATLQSYFDSFVDFSSKNPWFDCDLMYERQATDAALAVPLSERGVGPWRDSKINANFLVVTPSEEYDEAADAFVRPFMDRFQAVMGFDTLHVYVNEALGDEGPASWYGEENLPRLVALKQQWDPENKFGAGAPIPLSL
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the antitumor fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts (PubMed:20225828, PubMed:20804163, PubMed:21899262, PubMed:24612080, PubMed:33705521).  The simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from anthranilic acid (Ant), tryptophan (Trp), and alanine (Ala) (PubMed:20225828).  The trimodular NRPS fmqA is responsible for FQF formation (PubMed:20225828).  Modules 1, 2 and 3 of fmqA are predicted to activate and load Ant, Trp and Ala, respectively, providing for the assembly of an Ant-Trp-Ala-S-enzyme intermediate that would undergo double cyclization for chain release and generation of the tricyclic 6-6-6 product fumiquinazoline F (PubMed:20225828).  The presence of an E domain predicted for module 2 of fmqA is consistent with epimerization of L-Trp to D-Trp during assembly to generate the R-stereocenter at C14 of FQF (PubMed:20225828).  The FAD-dependent monooxygenase fmqB and the monomodular NRPS fmqC then maturate FQF to FQA (PubMed:20804163).  FmqB oxidizes the 2',3'-double bond of the indole side chain of FQF, and fmqC activates L-Ala as the adenylate, installs it as the pantetheinyl thioester on its carrier protein domain, and acylates the oxidized indole for subsequent intramolecular cyclization to create the 6-5-5-imidazolindolone of FQA (PubMed:20804163).  The FAD-linked oxidoreductase fmqD introduces a third layer of scaffold complexity by converting FQA to the spirohemiaminal FQC, presumably by catalyzing the formation of a transient imine within the pyrazinone ring (PubMed:21899262).  FQC subsequently converts nonenzymatically to the known cyclic aminal FQD (PubMed:21899262).
What are the official names of this protein?
FAD-linked oxidoreductase fmqD, Fumiquinazoline biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall. Note=Localizes to the cell wall of the conidia and In to both the cell wall and septa in the hyphae (PubMed:24612080).
Protein: PTH_SYNAS
Sequence: MKLIVGLGNPGARYRFTRHNFGFFVLDQLAEDQDIMMSQTGFDALWGKGVIAGQSVLLAKPQTFMNLSGKSVRKLADFFKIVVEDVLVVHDDLDLPFGVIRLKAGGGQGGHKGLISICDSLGGPEFQRVRLGIGKPAQRSAVERYVLEPFTESELRILPRIIVTARSAILEVISSGIKTAMNSYNGMVINDLIQEV
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANMK_PSEAE
Sequence: MPRYLGLMSGTSLDGMDIVLIEQGDRTTLLASHYLPMPAGLREDILALCVPGPDEIARAAEVEQRWVALAAQGVRELLLQQQMSPDEVRAIGSHGQTIRHEPARHFTVQIGNPALLAELTGIDVVADFRRRDVAAGGQGAPLVPAFHQALFGDDDTSRAVLNIGGFSNVSLLSPGKPVRGFDCGPGNVLMDAWIHHQRGEHFDRDGAWAASGQVNHALLASLLADEFFAARGPKSTGRERFNLPWLQEHLARHPALPAADIQATLLELSARSISESLLDAQPDCEEVLVCGGGAFNTALMKRLAMLMPEARVASTDEYGIPPAWMEGMAFAWLAHRFLERLPGNCPDVTGALGPRTLGALYPA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P (By similarity).  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.  Contributes to intrinsic fosfomycin resistance in P. aeruginosa (PubMed:24819062).
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: RL10_ANADE
Sequence: MNRTEKEQVIGELHEKMAKAKAAIVAEPKGLNVAVVTDLRKKLRDAKIDYRIVKNTLAARAAKGTPVEPVADRFVGPTALVMSYDDVVTPAKLLADFMKDRENFVIRTAIIEGKVVDAKGVQALAKLPGLKELRGQIAAMIAQPATKLARLVGTPGQQLARVVGARHEQLEKQG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: DPMPG_MACPH
Sequence: MSASSTEATNLAGKTCLITGGAGGLGRALAAAFLRAGANVAICDLNEERLKQASAELSGTGAGSLLAANADVADPAAAQQLFDRITAKFRTVDVLVNNAAIMDRFDPVADLDHELWDRVISVNLAGPFIFSKLALRVMLQQPKPDGCILNIASGAAKGGWLAGRCDLGLARICRG
What is the function of this protein?
Short chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350).  The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpmpA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable).  The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpmpD through the action of the prenyltransferase dpmpC to yield a linear alpha-pyrone diterpenoid (Probable).  Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpmpE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpmpB (Probable).  The short chain dehydrogenase/reductase dpmpG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpmpH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350).  Higginsianin B is further methylated by the methyltransferase dpmpI to produce the intermediate named FDDP B (PubMed:32286350).  The cytochrome P450 monooxygenase dpmpJ then oxidizes the C-26 methyl to primary alcohol, producing the final diterpenoid pyrone with a C-26 primary alcohol on the gamma-pyrone moiety named FDDP C (PubMed:32286350).
What are the official names of this protein?
Short chain dehydrogenase/reductase dpmpG, Diterpenoid pyrone biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: TTLL5_CHLAE
Sequence: MPVVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVHPSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVKPVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNYSVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDATLKPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRPLPAQFHSSEPKQRSRPLSASDAEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPELKIEGLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKDTPSLTTLVENTPKENSVKVREWSKKGERCCKLETQELEPKFNLMQVLQDNGNLSKVQARIAFSTYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQQSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKSSKNNNSYSDSGAKGDHPETVMEEAKMKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYTSSSSTPFSGPTATLQKIPNTHLSSVTTSDLSPGPGHHSSLSQIPSAIPSMPHQPTILLNTVSASASPSLHPGTQNIPSPAGLPRCRSGSHTIGSFSSFQSAAHIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQQEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQVTNLNLATGIINRSSASTPPTLQPIISPSGPTWLVQSDPQAPENHSSPPRSRSLQTGGFAWEGEVENNVYSKATGVVPQHKYHPTAGSYQLHFALQQLEQQKLQSRQLLDQSRARHQAIFGSQTLPNSNLWTMNNGAGCRISSATASGQKPTTLPQKAVPPPSSCASLVPKPPPNHKQVLRRATSQRASKGSSAYAQLNGLQSSLNPAASVPITSSTDPAHTKR
What is the function of this protein?
Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin.  Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step.  Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity).  Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules.  Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity).
What are the official names of this protein?
Tubulin polyglutamylase TTLL5, SRC1 and TIF2-associated modulatory protein, STAMP protein, Tubulin--tyrosine ligase-like protein 5.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm. Note=Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid.
Protein: NEDD8_RABIT
Sequence: MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLRQ
What is the function of this protein?
Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53.  Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.  Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity.  Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M.
What are the official names of this protein?
NEDD8, Neddylin, Ubiquitin-like protein Nedd8.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Nucleus. Note=Mainly nuclear.
Protein: VL1_HPV05
Sequence: MAVWHSANGKVYLPPSTPVARVQSTDEYIQRTNIYYHAFSDRLLTVGHPYFNVYNINGDKLEVPKVSGNQHRVFRLKLPDPNRFALPDMSVYNPDKERLVWACRGLEIGRGQPLGVRSTGHPYFNKVKDTENSNAYITFSKDDRQDTSFDPKQIQMFIVGCTPCIGEHWDKAVPCAENDQQTGLCPPIELKNTYIQDGDMADIGFGNMNFKALQDSRSDVSLDIVNETCKYPDFLKMQNDIYGDACFFYARREQCYARHFFVRGGKTGDDIPRAQIDNGTYKNQFYIPGADGQAQKTIGNSMYFPTVSGSLVSSDAQLFNRPFWLQRAQGHNNGILWANQMFITVVDNTRNTNFSISVYNQAGALKDVADYNADQFREYQRHVEEYEISLILQLCKVPLKAQVLAQINAMNSSLLEDWQLGFVPTPDNPIQDTYRYIDSLATRCPDKNPPKEKEDPYKGLHFWDVDLTERLSLDLDQYSLGRKFLFQAGLQQTTVNGTKAVSYKGSNRGTKRKRKN
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins.  Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment.  This binding mediates a conformational change in the virus capsid that facilitates efficient infection.  The virion enters the host cell via endocytosis.  During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus.  The virion assembly takes place within the cell nucleus.  Encapsulates the genomic DNA together with protein L2.
What are the official names of this protein?
Major capsid protein L1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L1 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: LOLB_SHEPC
Sequence: MNNLKRFTESIFSCIALSTLLFLGGCQTLPPADDLTPITVSHPDQAKAWELQGKLAIKTPEDKLSANLYWRHSEERDELTLTTMLGTTVLTLEATPNSAHLHIDGKDFKDNNAQDLLERVSGWSIPLADLPLWITGQIGSQDRVLSRDSKANPKQLINDQTPPSWVVEFLSWQLQSGAHIPHQLKLERGDLQLKLQINQWQALGKATIMIGEKP
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.