PharMolix/UniProtQA huggingface dataset:
Protein: LUXS_AERHH
Sequence: MPLLDSFTVDHTRMAAPAVRVAKTMQTPNKDTITVFDLRFCVPNQEILSERGIHTLEHLFAGFMRDHLNGNGVEIIDISPMGCRTGFYMSLIGAPDEARVGAAWQAAMSDVLTVQEQGKIPELNEYQCGTYSMHSLEEAHAIARHVLERGIGVNRNDELALPEEKLKSL
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: NUON_MYCSJ
Sequence: MNPEEAMRPLLMASEMMMFGAGLVALIAGSFLRRQRQWWVGVMAAAAQVGVIGVAVVQMVGPDQMAFEGAFSVDTATGVARIACAAGLLLIWAVAGAEMRASPREAETYALLMFSATGVLVLAGAEDLLLLVAGYFLASIPLYGLVGLARSAAAAEAAMKAYLMGALFGILLMLGVTILYGLTGATRYPQLAMTLSGAPAVAVAAGVVGVLAGLMFEAGGVPAHFWVPDAAQGANATAATFLTTVPKIGALVALYRLTTVLPDTLAWPVLIAVFAVISMTLGNLAAYWQQDPRRLLGWSTVSQVGYLLVPITVAGASELALPSLLFYLGGYTVTNIAAFAVTAALPGRRDLDSYRGLARTRPWLAAALVVALLGLVGTPPTAVFIGKVTTAAAAWDGRYAWLAVVVFVNTLVSLFYYLRWIIPAFGRPHETGDADQSAVQHWPARVAVLAAALSLLLGIIAGPVWQLVT
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MRPP3_RAT
Sequence: MTFYLSGFRSFLKLWKSNPYFELGPATSSASFFLGVHCVIGNQQRWFSVKPTTPPNSKILNLLVTKARTLKKGNDSNKQASSGPHYFAAGEAKKRSHLSGNPQNQGHTLPVKSTVQLPTKPLNSEEWDKLKEDFKGKASFEDFVISQMTRSCSSVDVAKSLLAWVAAKNNGIVGYNLLVKYLYLCVFHKQTSEVIDVYEIMKAKYKSLESGGYTLLIRGLIHSDRWREALLLLEDIKKVMVPSKKNYGDCIQGALLHQDVNVAWSLYQELVGHNLIPLLETLKAFFDHGKDMNDDQYSNQLLDILLYLRNNQLYPGESFAHSIKTWFESIPGRQWKGQFTTIQKSGQCSSCGRAIESIHLSPEEYEFLKETIMRDVIDGGDQYKKTTPQELKRFERFVKSCPPFDIVIDGLNVAKMFPKGRESQNLLGIVSQLAQQNLQLLVLGRKHMLRPSSQWRKDEMEQVRKQAHCFFADNISEDDPFLLYATLNSGSHCKFITKDLLRDHKACLPDARAQRLFFKWQQGHQLAITKGFLKSKLTFQHILSYDTVVQTTGDTWHIPYDEDLVPRSSCEVPTKWLCLQRKTPAPC
What is the function of this protein?
Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends.  The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.
What are the official names of this protein?
Mitochondrial ribonuclease P catalytic subunit, Mitochondrial ribonuclease P protein 3, Mitochondrial RNase P protein 3.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DAPF_PASMU
Sequence: MQFSKMHGLGNDFVVVDAITQNLYFSPETIKRLADRHRGIGFDQMLIVEPPYDPDLDFHYRIFNADGSEVSQCGNGARCFARFVTLKGLTDKKDIAVSTQTGKMILSIKDDGMIRINMGEPIWEPAKIPFTANKFEKNYILRTSIQTVLCGAVSMGNPHCVVQVDDIQTANVEQLGPLLENHERFPERVNAGFMQVIHRGHIKLRVYERGAGETQACGSGACAAVAVGVMQGLLDSKVQVDLPGGSLIIEWEGVGKPLFMTGDATHVYDGVIRL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_ECOBW
Sequence: MSEQLVTPENVTTKDGKINLLDLNRQQMREFFKDLGEKPFRADQVMKWMYHYCCDNFDEMTDINKVLRGKLKEVAEIRAPEVVEEQRSSDGTIKWAIAVGDQRVETVYIPEDDRATLCVSSQVGCALECKFCSTAQQGFNRNLRVSEIIGQVWRAAKIVGAAKVTGQRPITNVVMMGMGEPLLNLNNVVPAMEIMLDDFGFGLSKRRVTLSTSGVVPALDKLGDMIDVALAISLHAPNDEIRDEIVPINKKYNIETFLAAVRRYLEKSNANQGRVTIEYVMLDHVNDGTEHAHQLAELLKDTPCKINLIPWNPFPGAPYGRSSNSRIDRFSKVLMSYGFTTIVRKTRGDDIDAACGQLAGDVIDRTKRTLRKRMQGEAIDIKAV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IDH_HELPJ
Sequence: MAYNPKILQKPKEGEEITIKDGKLHVPNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM
What are the official names of this protein?
Isocitrate dehydrogenase [NADP], IDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: CANB_DEBHA
Sequence: MGVASSKILENLMEGTNFDKEEIERLRKRFMKLDKDGSGTIDKNEFLTIPGISSNPLAARLMDVFDEDGNGTIDFQEFIMGLSAFSGKTSKLDKLKFAFKIYDIDRDGYIGNGELFIVMKMMVGKNLQDEELQQIVDKTMMEADEDGDGRLNFHEFKNAVDSKSVASALTLNMI
What is the function of this protein?
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.  Confers calcium sensitivity (By similarity).
What are the official names of this protein?
Calcineurin subunit B, Calcineurin regulatory subunit, Protein phosphatase 2B regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
Protein: DER_TREPA
Sequence: MKGQDVILCDGGRHFSYKVLPRVVIVGRPNVGKSTLFNRLLGRRRSITSNTSGVTRDSIEETVILRGFPLRLVDTSGFTVFSEKKASRQHIDTLVLEQTYKSIQCADKILLVLDGTCESAEDEEVIQYLRPYWGKLIAAVNKTEGGEEVHYNYARYGFSTLICVSAEHGRNIDALERAIIQNLFSVDERRELPKDDVVRLAIVGKPNTGKSTLMNYLMRRTVSLVCDRAGTTRDVVTGHVEFKQYKFIIADTAGIRKRQKVYESIEYYSVIRAISILNAVDIVLYIVDARDGFSEQDKKIVSQISKRNLGVIFLLNKWDLLEGSTSLIAKKKRDVRTAFGKMNFVPVVPVSAKTGHGISDALHCVCKIFAQLNTKVETSALNTALKDWVTSYPPPRKYGHVSLKYLVQVSVRPIEFLLFANRPDRIPENYVRFLQNRIREDLGLDSIPVKLTIRKNCRKR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: PAPA5_MYCUA
Sequence: MFPGAVIRKLAFSEEIYARYQAFTSFTAHVRGPVDIDAMSEAFDALLQAHPVFAAHLEEGPDGNHHIVANDLLHSGLVVIDGRRAENPHVQLDQRDSLFRLQLTLGESENLVTAYVHHSLADAHHLGSLLDELLSRYTDVVTTGDPGPITPEPAPQPAEDLLKRRGIKQSALTGFERFLPLLFAYDLPPIAEEMRKFEAPEPVPVTRCRLTSQETADLVSFSRDNGLSFNAVLAAAILLAEWRLRETPHVPIPYCYAVDLRFLLSPPVGATESTNPVGLATYLAEIGPDTDITELAADIVATFRADLSDGMIHQSALRSGRILEGTPPGLPPFILCTNVSTLPPIRTPEDVELVDFHSRIHCAMDVPFGFYACSIATDRLSIELHGSIPAPQLLLDAIRDILCSVPSEYGLFME
What is the function of this protein?
Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis.  Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols.
What are the official names of this protein?
Phthiocerol/phthiodiolone dimycocerosyl transferase, Acyltransferase PapA5, Phthiocerol/phthiodiolone O-acyltransferase, Polyketide synthase-associated protein A5.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase PapA5 family.
Protein: MUTS_CLOBA
Sequence: MALTPMMVEYMKTKEEYNDCILFYRLGDFYEMFFDDALTVSRELELVLTGKNCGLEERAPMCGIPHHAAAAYIPRLVTKGYKVAICEQLEDPKQSKGIVKRGVVKVITPGTFIDSNSNLENDNTYLMVISEHEDKFGIAMSDISTGEFKTTSFNNIKMSLLDEISKVSPKEILVDNNISEDLLEEINNVLPVLITKKDFNEFLVSKEELIEQFSDLEVSGLTIEREIPSKVLLKYINETQKMSLTNINLLEQYEIINYMTIDGNSRRNLELTESIREKTKKGSLLWVLDKSATSMGGRTLRKWIDEPLIVKDEIEKRLSGVEEVFNSIGFNEDLRSALKEIYDIERIVGKISNKNVNAKDLLSLKSSLDKLPCIKKLLKDTSSELLKGYYENLDELIDVRDLLNDSIKEDPGLGLKEGNIIKDGYNNLVDELRQSKLHGKEWIAALENREREFTGIKSLKVGYNKVFGYYIEISKSNYNSIPEGRYIRKQTLANAERFITEELKVMEDKILGSEEKLINLEYSIFVEIRDKIEKEISRLKKSARIISDLDGISTLALVALENDYIKPEINTNGLIKITDGRHPVVEKVIGKGDFVSNNTALNQTDKELLLITGPNMAGKSTYMRQVALITLMAQMGSFVPATSANISICDKIFTRIGASDDLAGGKSTFMVEMWEVSNILKNATSNSLVLLDEVGRGTSTYDGLSIAWSVIEYITKNKNLRCKTLFATHYHELVKLEGILPGVKNYSVAVKKLKDSVVFLRKIVEGGADESYGIEVAKLAGLPENVINRAREILEDLESKNTFDINKLSSCSMVSNNTKEIAADSIKNEEDKVISNAQNIDVNETNCNYNEEKILKIETQNSEYEETIKFLKSEIKELQESNKKHNKKHKDASNDNMQINFEVMEKENFIKEISDVDILNLNPMEAMNTLYKVVTDAKKLQ
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: OTSA_MYCPA
Sequence: MAPGGGRGSKTAGYGNSDFVVVANRLPVDQERLPDGSTAWKRSPGGLVTALEPLLRRQRGAWVGWPGIVDEDVDHEDDPIVQDDLELRPVKLSADDVAEYYEGFSNATLWPLYHDVIVKPIYHREWWDRYVAVNRRFAEATSRAAARGATVWVQDYQLQLVPAMLRELRPDLTIGFFLHIPFPPVELFMQLPWRTEIVKGLLGADLVGFHLTGGAQNFLFLSRRLIGANTSRGAVGMRSRYGEVELESRVVRVGAFPISIDSTALDQTARHRDIRRRAREIRAELGNPRKVLLGVDRLDYTKGIDVRLKAFSELLAEGRAKRDDTVLVQLATPSRERVDSYQQLRNDIERQVGHINGEYGEVGHPVVHYLHRPVPRNELIAFFVAADVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRQAYLVNPHDLEGVKDTVEAALNQSVEEGRRRMRSLRRQVLAHDVDRWARSFLDALAESGPRDG
What is the function of this protein?
Probably involved in the osmoprotection via the biosynthesis of trehalose and in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1-phosphate (M1P).  Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate.  Probably also able to use ADP-Glc, CDP-Glc, GDP-Glc and TDP-Glc as glucosyl donors.
What are the official names of this protein?
Trehalose-6-phosphate synthase, TPS, Alpha,alpha-trehalose-phosphate synthase [UDP-forming], Osmoregulatory trehalose synthesis protein A, OtsA.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 20 family.
Protein: K2C75_MOUSE
Sequence: MSRQSTITFHSGSRRGFSTASATTPTAGRSRFSSVSVARSSGNSGGLGRISGIGSGFGSRSLYNLGGTRRVSIGGCAGSGFRGGFGGRTSSGFGGSSGFAYGGGIGGGFGGPGFSVCPSGGIQEVTVNQSLLTPLNLQIDPTIQRVRKEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQEQGSRTVRQNLEPFFDTYVNDLRRQLDGITAERGRLDAELRNMQEVVEDFKVRYEDEINKRAAAENEFVGLKKDVDSAYMNKVELEAKVDSLTDQINFYRMIYEAELSQMQNQVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRSEIDAVKKQCSSLQTAISDAEQRGELALKDARAKLMELEDALQKAKQDMARLLREYQELMNVKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTVSSGYGGGANIGGGSLGLGGNSGYSFTTSGGHSLGTGLGGSGFTTTSSRGPVGSGSSIKFVSSTSSRKSYKH
What is the function of this protein?
Plays a central role in hair and nail formation.  Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity).
What are the official names of this protein?
Keratin, type II cytoskeletal 75, Cytokeratin-75, CK-75, Keratin-6 hair follicle, mK6hf, Keratin-75, K75, Type II keratin-K6hf, Type-II keratin Kb18.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: Y2519_HALMA
Sequence: MSRSALVENVMAMLEDAGFLVSDRCAIRPKSFDIAARRGEDVLLLKILGNIDAFDAQTGGEMRRLGTYLNATPIVIGLRTRDEELKPGVVYFRHGVPVLSPDTAMDLFVEEVPPLIYAAPGGLYVNIDSEILADVREDRDWSLGRLAKELGVSRRTVSKYEDGMDASVEVAAELEDLFDAPLTSPVSVLDGAEEVRDDEPTPDDPDVAPEDEPIVTVFTRIGFEVHPTDRAPFKSVNESDDEHGQVLAGHSAFTETAEKRARIMSSVGEVTRTRSVYVVDELRRESVEGTALIEKEEMENIEDAIDLRDLIMERGEDREEVA
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein rrnAC2519.
Protein: METAS_TOLAT
Sequence: MPIKIPDQLPAAGVLTEENIFVMTDSRAAHQDIRPLKVLLLNLMPKKIETEIQLMRMLSNSPLQVLVDLLRIDDRESKNTPRIHVETFYQDFDQIKDNKYDGLIITGAPLGLVQFDDVVYWDTLIKIIEWSKKNVTSTLFLCWAAQAALKVLYGLEKQTRGEKLSGVYYHHKLEQQDPLVRGFDDVFLAPHSRYASFEGDFIRANTDLRIFAESEEAGVYLAATKDCRQVFVTGHPEYDAETLHHEYHRDLTAGINPNVPANYYPGNDPARPPYHSWRSHGHLLFSNWLNYYVYQLTPYDLDTLDQKAGGVDWEI
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_PROM0
Sequence: MAIRKFKPYTPGTRQRVVTDFSEITSSKPERSLIVSKHRVKGRNNRGVITCRHRGGGHKRQYRLVDFRRDKRNINAKVAAIHYDPHRNARLALLFYEDGEKRYIIAPAGVKVGQNVISGESVPIEDGNAMPLSVMPLGSSVHCVELYAGRGAQMVRSAGASAQVMAKEGDYVALKLPSTEVRLVRKECYATLGEVGNSEIRNTSLGKAGRRRWLGRRPQVRGSVMNPCDHPHGGGEGKAPIGRAGPVTPWGKPALGLKTRKKNKPSNKLVVRRRRRISKRSRGGRDS
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: ISPE_TREPS
Sequence: MQSLSLRAHAKVNMHLWVGARRADGLHSIESVMQRITLADSLSLSRLDIPGRCEVCSPYMALPRENTLTRAYARFCQVTGVHDGVRVRVVKRIPAGSGLGGGSADAAALLCGLDTLFGTTLSARVLREVAYSVGSDVPFFLASQAACVLGGGEQLVPLVPKTGYLGLLVWPGLHSGSAQAYEDLDRLRACGVHAADGEQYSLRGATALSAHYAQDCARWRFFNSLDAPVQRRYPVVALARWDLARAGACFTAMSGSGSXVFGLYRDEEELRRAHKLLAKRWCWCVRVRLCG
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: NSMA2_MOUSE
Sequence: MVLYTTPFPNSCLSALHAVSWALIFPCYWLVDRLLASFIPTTYEKRQRADDPCCLQLFCTVLFTPVYLALLVAALPFAFLGFIFWSPLQSARRPYSYSRLEDKNPAGGAALLSEWKGTGAGKSFCFATANVCLLPDSLARLNNVFNTQARAKEIGQRIRNGAARPQIKIYIDSPTNTSISAASFSSLVSPQGGDGSRAVPGSIKRTASVEYKGDGGRHPSDEAANGPASGEQADGSLEDSCIVRIGGEEGGRPQEADDPAAGSQARNGAGGTPKGQTPNHNQRDGDSGSLGSPSASRESLVKARAGQDSGGSGEPGANSKLLYKTSVVKKAAARRRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAAAKLKEQLHGYFEYILYDVGVYGCHGCCNFKCLNSGLFFASRYPVMDVAYHCYPNGCSFDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPPEDSAVRCEQLDLLQDWLADFRKSTSSTSTANPEELVVFDVICGDLNFDNCSSDDKLEQQHSLFTRYKDPCRLGPGEEKPWAIGTLLDTNGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSPGAGQKGRKDLLKGNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSAGEEEA
What is the function of this protein?
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine.  Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently.  Also hydrolyzes sphingosylphosphocholine.  Regulates the cell cycle by acting as a growth suppressor in confluent cells.  Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:15051724, PubMed:15764706, PubMed:15929065, PubMed:16025116).  Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location (PubMed:21550973).  May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity).  May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity).
What are the official names of this protein?
Sphingomyelin phosphodiesterase 3, Neutral sphingomyelinase 2, nSMase-2, nSMase2, Neutral sphingomyelinase II.
What is the protein family that this protein belongs to?
Belongs to the neutral sphingomyelinase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid- anchor. Note=May localize to detergent- resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons (PubMed:15764706).
Protein: ICAD_STAAM
Sequence: MVKPRQREYPTLKSSLNIVRETALIAISCVFWIYCLVVLLVYIGTIFEIHDESINTIRVALNIENTEILDIFETMGIFAIIIFVFFTISILIQKWQRGRES
What is the function of this protein?
Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide.  Is required for full IcaA N-acetylglucosaminyltransferase activity (By similarity).
What are the official names of this protein?
Poly-beta-1,6-N-acetyl-D-glucosamine synthesis protein IcaD, PGA synthesis protein IcaD, Poly-beta-1,6-GlcNAc synthesis protein IcaD, Biofilm polysaccharide intercellular adhesin synthesis protein IcaD, Biofilm PIA synthesis protein IcaD, Intercellular adhesion protein D.
What is the protein family that this protein belongs to?
Belongs to the IcaD family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATS19_MOUSE
Sequence: MGPEMRLTRICCCCCLLYQLGFLSHGTTSGLQLTPDLEEWEVVFPALWRRESLNATGLSGGSSDPGSGRSSGGGGRGQASGSSREVRSVARAPQEEATRGQSEPWFGSPLEPGAEDEEELESQELPRGSSGDTALSSGTPASWQPPLPPQRPSSPPPAQQEEPSAEEVLLRIPALSRDLYLLLRRDGRFLAQRFAVEQWPKPGPDPTRATADPGSSLLPDASCFYTGTVLRHPGSLASFSTCGGGLMGFIQLNEDFLFIEPFNDTMAIIGHPHRLYRQKRSTEEKVTENSAVHRHHCGVISDKGRPRSKKIADNRREKRYSYKLSQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLGVQVNLRVLKLILLHETPADLYIGHHGEKMLESFCKWQHEEFGRRNDVHLEMSTSWGEDIAAVDAAILITRKDFCVHKDEPCDTVGIAYLNGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASSCLLHTDPQSLSSVLVPSKLPGMAYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEAECRTKLDPPMDGTDCDPGKWCKAGECTRRTPAPEHLAGEWSPWSSCSRSCSSGVSSRERKCPGLGSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSYPKHALQWQAVFDEEKPCALFCSPVGKEQPVLLSEKVMDGTSCGYQGLDICANGRCQKAGCDGLLGSLAREDHCGVCNGNGKSCKVIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSFLALRDASKQSINSDWKIEHSGAFSLAGTTVHYLRRGLWEKISAKGPTTTPLHLLVLLFQDQNYGLHYEYTVPSDPLPDNQSSKEPGPLFMWTHAGWGDCNATCGGGERKTMVSCTKIMSKNISLVDNKKCKDLTKPEPQIRKCNEQPCQTRWMMTEWTTCSRTCGKGVQSRQVACTQQLENGTLIRAWERDCLGPKPATVQRCEGQDCMTVWEAGVWSECSVKCGKGVRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRVGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQQKS
What are the official names of this protein?
A disintegrin and metalloproteinase with thrombospondin motifs 19, ADAM-TS 19, ADAM-TS19, ADAMTS-19.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: RECA_HAEIG
Sequence: MATQEEKQKALAAALGQIEKQFGKGSIMKLGDTKTLDVESISTGSLGLDVALGIGGLPMGRIVEIFGPESSGKTTLTLSVIAQAQKAGKTCAFIDAEHALDPIYAAKLGVDVKELFVSQPDNGEQALEICDALVRSGAIDVIIVDSVAALTPKAEIEGDMGDSHMGLQARLMSQALRKLTGQIKNANCLVVFINQIRMKIGVMFGNPETTTGGNALKFYSSVRLDIRRTGSVKDGENIIGNETRVKVVKNKLAAPFRQVDFQILYGEGISKAGELLELGVKHKLVEKSGAWYSYNGEKIGQGKANSMKWLNENIEKSDELEARLRAELVANPEQALMADIEQSENNTESESDFE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OR5T3_HUMAN
Sequence: MDSTFTGYNLYNLQVKTEMDKLSSGLDIYRNPLKNKTEVTMFILTGFTDDFELQVFLFLLFFAIYLFTLIGNLGLVVLVIEDSWLHNPMYYFLSVLSFLDACYSTVVTPKMLVNFLAKNKSISFIGCATQMLLFVTFGTTECFLLAAMAYDHYVAIYNPLLYSVSMSPRVYVPLITASYVAGILHATIHIVATFSLSFCGSNEIRHVFCDMPPLLAISCSDTHTNQLLLFYFVGSIEIVTILIVLISCDFILLSILKMHSAKGRQKAFSTCGSHLTGVTIYHGTILVSYMRPSSSYASDHDIIVSIFYTIVIPKLNPIIYSLRNKEVKKAVKKMLKLVYK
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 5T3, Olfactory receptor OR11-178.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SYT_CLOPE
Sequence: MIKITLKDGSIKEVEAGLSIFEIAQSISQGLARNACCGILNGKVEDLRFIVNEDSSLEICTFDSKEGQHAFNHTASHVLAAAVKRLFPQDKLAIGPSIDNGFYYDFDTEKPFSADQLNKLEEEMKKIIKENPEIKRFELPRNEALELMKDEPYKVELINDLPEGEVISFYQIGDFVDLCAGPHLMAVKPIKAVKLLRSTGAYWKGDEKNKMLSRVYGTAFPKKSELDAYLEALEEAKKRDHNKLGRELGIFTTDENVGQGLPLLMPKGARIIQTLQRWIEDEEQRRGYVLTKTPLMAKSDLYKISGHWDHYKDGMFVLGDEEKDSEVFALRPMTCPFQYAIYNSTQHSYRDLPVRFAETSTLFRNESSGEMHGLIRVRQFTLADGHIVCTPEQLEDEFKNTVDLVKYVMETLGIADDITYRFSKWDPNNTEKYINDPEAWENTQNIMREILNHLNIDFTEADDEAAFYGPKLDIQFKNVHGKEDTIITIQIDFALAERFGMYYIDKDGEKKRPYIIHRSSIGCYERTLAMLIEKYAGALPTWIAPVQAKVLPLSDKYADYANEVVEELRRRGVRVEADHRAEKIGYKIREARLERTPYILVVGEKEAENKEVSVRSRKNGEEGAMPLADFVNRIVLEIANREN
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBE_TATCI
Sequence: MNKKILFIPLVLFLLLAAALLWQFNRNADGDDPTLLESALVGKPVPVFKLESLQNPGQLYSQKALINGKPLLLNVWATWCPTCRAEHEYLNTLAEKGVRVVGLNYKDNRVKAINWLNTLGNPYALSLYDGDGMLGLDLGVYGAPETFLIDGKGIIRYRHAGDLNAEVWKDEVQPLWNKYSKLAED
What is the function of this protein?
Involved in disulfide bond formation.  Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme.  Possible subunit of a heme lyase (By similarity).
What are the official names of this protein?
Thiol:disulfide interchange protein DsbE, Cytochrome c biogenesis protein CcmG.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family. DsbE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: OTNK_HAEIN
Sequence: MLGVIADDFTGASDIASFLVENGLSTVQMNGVPTQSLNSKVDAIVISLKSRSNPVNEAIEQSLRAYQWLKENGCTQFYFKYCSTFDSTAKGNIGPVTDALLDELNEDFTVITPALPVNGRTIFNGYLFVGDVLLSESGMKNHPITPMVDANLMRLMDAQAKGKTGLVAYADVIKGASRVQECFAELKAQGYRYAVVDAVDNSQLEVLAEAVADFKLVTGGSGLGAYMAARLSGGKKGTNAFTPTKGKTVVLSGSCSVMTNKQVEKYREKAPHFQLDVEQAIHNENYIEQLYQWVIANLDSEFAPMVYATVPPDALKAIQHQFGVDQASHAIENTFAKLAAKLKQYGVTNFITAGGETSSIVVQELGFTGFHIGKQIAPGVPWLKAVEEDIFLALKSGNFGKEDFFEYAQGMFL
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of 3-oxo-tetronate to 3-oxo-tetronate 4-phosphate.
What are the official names of this protein?
3-oxo-tetronate kinase, 3-dehydrotetronate 4-kinase.
What is the protein family that this protein belongs to?
Belongs to the four-carbon acid sugar kinase family.