PharMolix/UniProtQA huggingface dataset:
Protein: HACL2_BOVIN
Sequence: METAVAAAPAWGFFSSFLLLAFGTLVAALLGAAHRLGLFYQLMHKVDTASTRHGGENVAAVLKAHGVRFLFTLVGGHISPLLVACEKLGIRVVDTRHEVTAVFAADAVARLTGTVGVAAVTAGPGLTNTVTAVKNAQIAQSPVLLLGGAASTLLQNRGALQAIDQIALFRPLCKFCASVRRVRDIIPTLRAAMAAAQSGTPGPVFVELPLDVLYPYFMVQKEMVPAKPPKGLMSRAVHWYLANSLANLFAGAWEPQPEGPLPLDIPQASPQQVQRCVEILSRAKKPLMLIGSQALLPPTSSDKLRVAVETLGIPCFLAGMARGLLGRNHPLHFRQNRRAALKKADVVVLAGAVCDFRLSYGRVLSRSSKIIVVNRDRKEMLINSDIFWKPQEAVQGDVGSFVVKLVEGLRGQMWASDWAEELRQADQQKEQAFREKALMPVAQHLNPVRVLQLVEDTLPDNSILVVDGGDFVGTAAYLVQPRGPLRWLDPGAFGTLGVGAGFALGAKLCRPDAEVWCLFGDGAFGYSLIEFDTFVRHKIPVMALIGNDAGWTQISREQVPSLGSNVACGLAYTDYHKAAQGLGAQGLLLSRENEDQVVKVLRDAQQWCQDGHPVVVNILIGRTDFRDGSIAM
What is the function of this protein?
Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner.  Involved in the phytosphingosine degradation pathway.
What are the official names of this protein?
2-hydroxyacyl-CoA lyase 2, Acetolactate synthase-like protein, IlvB-like protein.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: SYGB_SYNC1
Sequence: MSAELFLEIGTEEIPAGFLPTAMADLERLIRKELETGRIGFETVRTFATPRRLVLAVTGVASGQARQEVTASGPSVSVAFDADGNPTKAALGFARSNGVEVSDLERRETDKGEYLFVSKVVEGRPTGELLPEMLPRIIAAIPFKKSMRWKDLDIRFARPMHWIVALFDGQVVPFSYGNLTSGNLSYGHRFMAPDAFEVSSLEQYLVEAEKHFVIVDPVKRRQIISDQLAEVVGRCGGKLNPDDDLLDEVAFLVEYPAAVMGGFEDSYLQLPPELLITVMREHQRYFTVVDDSGKLLPRFITISNTRAEDLTVVQQGNERVLRARLSDAMFFWNEDRKVKLESRLDALKNVVYQAKLGTSYEKVMRFKTLAVELAQQQVPEVVELTERAASLAKCDLETGMVFEFTELQGVMGREYALLDGEDPRVARAIFEHYLPVQAGGELPGDDVGAFVSIADKIDSICGCFGVGLIPTGTADPFALRRSAIGILNIILDRGYRLSLPALVERSLGLLADKLTRPATEVAADVLEFLRLRFFNMLTAQGLPNDVVDAVLSAAFEDPVDALQRVKGLASFREEGEFEALAVTFKRVVNIVKGGVDTSVDSALFEADCEAGLFDALQNVTGRFEQFVAEGAYLDALRTVGGLRSPVDALFEGVMVMSPDEAVKTNRLALLTAVARLFQGIADFSKIAA
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAHH_RHILO
Sequence: MTGSKDYVVADISLAGWGRKELDIAETEMPGLMACREEFGAKKPLKGARITGSLHMTIQTAVLIETLKALGADIRWASCNIFSTQDHAAAAIAEAGIPVFAVKGESLEQYWDYTDRIFQWADGGLSNMILDDGGDATMYILIGARAEAGEDVLSNPQSEEEEYFYAQVKKRLKASPGFFTKQKAAIRGVTEETTTGVNRLYQLQKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRGTDTMMAGKVAVVCGYGDVGKGSSASLKGAGARVKVTEVDPICALQAAMDGFEVVTLEDAAPTADIVITTTGNKDVVTLDHMRSMKDMVIVGNIGHFDNEIQVASLRNLKWTNVKPQVDMITFPDGKRMILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELFTKGEQYQNQVYVLPKHLDEKVARLHLDKLGARLTELSGEQAAYIGVTPQGPFKPEHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTI12_XENLA
Sequence: MPLILLCGFPCSGKSSRSQELQEHLEQSGRKVHIIGDHVLGVDRNAVYADSREEKDLRGSLRAAVERKLNKEDVVILDSLNYIKGYRYELFCLIKHVQTPHCLIHCITSPEVSSTWNQHRDKNEQYNQEIFDSLVQRFEFPDSRNRWDSPLFSVHKDEKLPLEQICNAIFHRKAPPPNQSTQMQPLSSTNFLHELDKVTQEVVTAVLSAQKTSIPGDVIMVPGASEKVQLPRILSMSELRRLRQQFISYTKLHPNENISQLANMFVQYLNQSIHG
What are the official names of this protein?
Protein KTI12 homolog.
What is the protein family that this protein belongs to?
Belongs to the KTI12 family.
Protein: UPPP1_CLOAB
Sequence: MEHIEILKAIFLGIVEGITEWLPISSTGHMILVNEFIRLNVTEAFKQVFLVVIQLGAILSVVLLYFNKLIPFSLNGGFYLKKDVVSMWIKIIISCIPATIVGIPFDDKIDALFYNYQTVSITLISFGILFIMIENHNKGKHPRITSISEITYTTAVLIGIFQLIAAVFPGTSRSGATIVGALLIGVSRTVAAEYTFFLAIPVMFGASLLKLFKFGLHFTSTEITILFIGMLSAFIVSILAIKFLMIYIKRHDFKAFGWYRIILGCAVLVYFLIV
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 1, Bacitracin resistance protein 1, Undecaprenyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS11_THISH
Sequence: MAQAPTRTRKKVKKTVSDGIAHIYATFNNTIVTITDRQGNTLSWATSGGSGFRGSRKSTPFAAQVAAERAGTAAQEYGLKNLEVLVRGPGPGRESAVRALNNAGFKILNISDITPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: YL737_MIMIV
Sequence: MVAPRISPKIVLVGFALFAIISASLAFPSGLNCPDPKPYPKFFLDSLWSGPSGYLGTTLIQGYVMIDTTGEFDFAKVASINGTFLQYYSKVLGTYVSEMYINLFGQQVKVMEAPFTLLERNPFNRFGEYCMVSNPRSVMPGYVEGLPITNKFFYNTYYNDTHGKSFGNVEQSEYFFFDETRNNSINCLTEFNPDATIKTFTCYKFQKVSNNVIPPTSKRSIEDMDSLRIGGLDLPEELVAPKYRHYFK
What are the official names of this protein?
Uncharacterized protein L737.
Protein: CYC_BRANA
Sequence: ASFDEAPPGNSKAGEKIFKTKCAQCHTVDKGAGHKQGPNLNGLFGRQSGTTAGYSYSAANKNKAVEWEEKTLYDYLLNPKKYIPGTKMVFPGLKKPQDRADLIAYLKEATA
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: ACPS_STRPJ
Sequence: MIVGHGIDIEELASIESAVTRHEGFAKRVLTAQEMERFTSLKGRRQIEYLAGRWSAKEAFSKAMGTGISKLGFQDLEVLNNERGAPYFSQAPFSGKIWLSISHTDQFVTASVILEENHES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA2D3_MOUSE
Sequence: MAGPGSLCCASRGASALLATALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKIMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDVVWTEAYIDSTLPQAQKLADDQGLVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIAGSFVYSIPFSTGTVNKSNVVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNNGFILVSEDYTQTGDFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGLLDPYKAFLSAAKWIMTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFHPEENARECGGASSLQAQAALLLLPLVSSLFSR
What is the function of this protein?
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.  Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).
What are the official names of this protein?
Voltage-dependent calcium channel subunit alpha-2/delta-3, Voltage-gated calcium channel subunit alpha-2/delta-3.
What is the protein family that this protein belongs to?
Belongs to the calcium channel subunit alpha-2/delta family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PHYB_ASPNG
Sequence: MPRTSLLTLACALATGASAFSYGAAIPQSTQEKQFSQEFRDGYSILKHYGGNGPYSERVSYGIARDPPTGCEVDQVIMVKRHGERYPSPSAGKSIEEALAKVYSINTTEYKGDLAFLNDWTYYVPNECYYNAETTSGPYAGLLDAYNHGNDYKARYGHLWNGETVVPFFSSGYGRVIETARKFGEGFFGYNYSTNAALNIISESEVMGADSLTPTCDTDNDQTTCDNLTYQLPQFKVAAARLNSQNPGMNLTASDVYNLIVMASFELNARPFSNWINAFTQDEWVSFGYVEDLNYYYCAGPGDKNMAAVGAVYANASLTLLNQGPKEAGPLFFNFAHDTNITPILAALGVLIPNEDLPLDRVAFGNPYSIGNIVPMGGHLTIERLSCQATALSDKGTYVRLVLNEAVLPFNDCTSGPGYSCPLANYTSILNKNLPDYTTTCNVSASYPQYLSFWWNYNTTTELNYRSSPIACQEGDAMD
What is the function of this protein?
Catalyzes the hydrolysis of inorganic orthophosphate from phytate.
What are the official names of this protein?
3-phytase B, 3 phytase B, Myo-inositol hexakisphosphate phosphohydrolase B, Myo-inositol-hexaphosphate 3-phosphohydrolase B.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family.
Protein: IXTPA_HALHL
Sequence: MKIVLATGNAGKLAEMTRMLQGYDAEVVRQGHLGIDSPAETGLTFVENALIKARHCAERSGLPAVADDSGLAVPALGGEPGIYSARYAGSDAGDAANIERLLAELSERGQGDRRGTFHCVMVYLRHAADPAPVIAHGSWTGRIVETPRGHHGFGYDPVFEDPELGQTAAELDAPAKDARSHRGQALRALIQGIAAEVAG
What is the function of this protein?
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP.  Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
dITP/XTP pyrophosphatase, Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase, Nucleoside-triphosphate diphosphatase, Nucleoside-triphosphate pyrophosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the HAM1 NTPase family.
Protein: RL14_FLAPJ
Sequence: MVQQESRLRVADNTGAKEVLTIRVLGGTKRRYASVGDKIVVSIKDTAPNGSVKKGSVSTAVVVRTKKEVRRADGSYIRFDDNACVLLNAAGEMRGTRVFGPVARELREKQFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RL18_RICTY
Sequence: MRSAKLKFEKRKSRIRHKISRTSNRVRLSVFKSGRHIYAQIIDDSKSITIASASTLDKTIKKIKKSHCNVENAIKIGREIAKKANSAGIKEVVFDRGGYKYHGIIKALADAAREKITF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CH60_MYCKA
Sequence: PYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVKEGLRNVAAGANPLGLKRGIEKAVEKVTETLLKGAKEVETKEQIAATAAISAGDQSIGDLIAEAMDKVGNEGVITVEESNTFGL
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, 65 kDa heat shock protein, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_FRATH
Sequence: MSFLVAIVGRANVGKSTLFNVLTNSHDALVFDFEGVTRDRQYGQAKYDDLDYLVVDTGGISDKDVGFDEFMAKQSQIAIDEANLVFFVVDGRSGLTTGDEYVASLLRQKDKKVVVVVNKVDGTDEEAAMAEFYSFGFDKVFAISAAHRRNTQKLVDKFLKKPLNEYYQDYTQTQEHKEQQRHGIHFSLIGRPNVGKSTLTNRMLGEDRVVVFDMPGTTIDSVSIPFERHGQKYTIVDTAGVRKRGKVKQTLEKFSVIKTLQAIQDSNVVVAVVDARQGISDQDLSLIHFAIKNGRALVLAVNKWDGMTEEDRIQVKQDLKRKLFFLQDYVDIHFISALYGTNVGHVFESIDTAYACANKKITTADATRLMQLAVEAHSPPMVGKFRIKLKYAHVGGHNPPVIVIHGNQVSRLPNSYKRYLENFFREALDFRGTPIVFEFKQSENPFADRKNKRSKDEGSKSKKVK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: KCY_METAR
Sequence: MIITLSGQPGSGKTSVAKELAEKYGFVVISAGEQFRKLAAERGMTLEEFGRLAENDPSIDLAIDQRQKELSRQFPNVLVEGRLAGRTIEADMRIWLKTPLRIRAERISNRENIPVHRAYDETHAREICELSRYKKYYDIDLTDLSCYDLVIDTSKWDAKGVSSIIFKAIDELKKA
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LHTL3_ARATH
Sequence: MKGIPSSSNQILNQDLVEDQSFELEDWLPITASRNANWYYSAFHNVTAIVGAGVLGLPYAMSELGWGPGVVVLILSWVITLYTFWQMIEMHEMFEGKRFDRYHELGQAAFGKKLGLYIVVPLQLLVETSACIVYMVTGGESLKKIHQLSVGDYECRKLKVRHFILIFASSQFVLSLLKNFNSISGVSLVAAVMSMSYSTIAWVASLTKGVANNVEYGYKRRNNTSVPLAFLGALGEMAFAYAGHNVVLEIQATIPSTPENPSKRPMWKGAIVAYIIVAFCYFPVALVGFWTFGNNVEENILKTLRGPKGLIIVANIFVIIHLMGSYQVYAMPVFDMIESVMIKKWHFSPTRVLRFTIRWTFVAATMGIAVALPHFSALLSFFGGFIFAPTTYFIPCIIWLILKKPKRFSLSWCINWICIILGVLVMIIAPIGGLAKLMNALKQPDSSCKST
What is the function of this protein?
Amino acid transporter.
What are the official names of this protein?
Lysine histidine transporter-like 3.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FMAE_ASPFU
Sequence: MDQSMKPLLSPTERPRRHLTASVISFFLPNQFRLSTILCIGALLQTILCAVLPLRYAAVPCVTVLLISVLTTIQECFQPNTNSFMADVIRGRTTAQIPGKDGTHGREPGKGSVVVFHLGIQYNHPLGVFAPHMREISNRFLAMQQDILRRKDELGLLAVQNWRGSERDSGNTTLIKYFFKDVESIHKFAHEPLHKETWTYYNQHHPGHVGIFHETFITKDGGYESMYVNCHPILLGRGEVKVNNRKDGTEEWVGTLVSADTPGLKSFKARLGRDD
What is the function of this protein?
Monooxygenase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:23488861, PubMed:24568283).  Within the pathway, the monooxygenase af470 catalyzes the oxidative cleavage of prefumagillin to yield the final compound of the pathway, fumagillin (PubMed:24568283).  The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans-bergamotene by the membrane-bound beta-trans-bergamotene synthase af520.  The multifunctional cytochrome P450 monooxygenase af510 then converts beta-trans-bergamotene into 5-keto-demethoxyfumagillol via several oxydation steps.  5-keto-demethoxyfumagillol is then subjected to successive C-6 hydroxylation and O-methylation by the dioxygenase af480 and O-methyltransferase af390-400, respectively, to yield 5-keto-fumagillol, which is then stereoselectively reduced by the keto-reductase af490 to 5R-hydroxy-seco-sesquiterpene.  The next step is the polyketide transferase af380-catalyzed transfer of a dodecapentaenoyl group synthesized by the polyketide synthase af370 onto 5R-hydroxy-seco-sesquiterpene which leads to the production of prefumagillin.  Finally, oxidative cleavage by the monooxygenase af470 converts prefumagillin to fumagillin (PubMed:24568283) (Probable).
What are the official names of this protein?
Monooxygenase af470, Fumagillin biosynthesis antibiotic biosynthesis monooxygenase superfamily monooxygenase, Fma-ABM.
Protein: RL21_CLOPS
Sequence: MYAVLTTGGKQYRVQEGDVLFVEKLNAEVDSTVELTEVLAVAKDGEIKVGAPVVEGAKVVAKVLAQGKAKKVVVFKYKRKKDYRRKNGHRQPYTKIVIEKIEA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: NDB4T_HETPE
Sequence: MKTQFAILLITLVLFQMFSQSDAILGKIWEGIKSIFGKRGLNDLSDLDELFDGEISEADVDFLREIM
What is the function of this protein?
Amphipathic peptide with antibacterial activities (By similarity).  Shows antiviral activities against the herpes simplex virus type-1.  It potently inhibits the initial infection by provoking the rupture of viral envelop and the dissociation of proteins from the virions (EC(50) is 0. 43 uM).  It also effectively inhibits viral attachment (EC(50) is 2. 87 uM), viral entry (EC(50) is 4. 29 uM) and viral proliferation after infection (EC(50) is 7. 86).  Morever, it enters mammalian tested cells (Vero) and reduces the intracellular infectivity.
What are the official names of this protein?
Peptide Hp1036.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: AROK_HISS2
Sequence: MAEKRNIFLVGPMGAGKSTIGRQLAQILGMEFIDTDAEIEQRAGADISWIFDVEGEEGFRKREERIINELTQKQGIVLSTGGGAIVSKDNRNYLSARGTVIYLETTVEKQFQRTQRDKKRPLLQNVEDPRQVLEDLAKVRNPLYEEVADIILPTDEQSAKLMANQIIDLIDNLKI
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_RICPR
Sequence: MTLDKLIEKLAAKFRIVITKVAVKDHLAYKIEPHFLLPFLKALKESEELRFTVLTDLFGVDFPKKEKRFEVVYNLLSLKLNKNLIIKTHISEKESIPSAMQILSAAYWYELEVYDMYGVNFNGNNDKRRILTDYDFEGHPLRKDFPLTGYTQVKYDKKLEKVTYEPVNLDIEYREFDFSSHWHSPSYVLPGDEKTEE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RSB1_YEAS8
Sequence: MSNATNNTLGSLLPQLEAAANSNSLYGGMVPNLRFNITMIVIWGILLTIHVVQLLMRQYWFSIAFICTGILEVLGYIGRTWSHSNVADMDAFLLNMICLTIAPVFTMGGIYYQLAKLIEVYGHRFSLLPSPMAYSFIFICSDIVSLVVQAVGGGLCGVAVTDGTSTTTGNHVFIAGLAIQVASMAIFLMLWFHFLFRIYISVRWEHINSRPISLSLLKISQTEVDYLYREKFHFLRLEPKRWVFHYFNLAMTVAVLTIFTRCCYRLAELVVGWDGYLITHEWYFIILDALMMAIATVTLTIFHPGFAFKGRSTSIPITPGHVDPETLPHTDDVEDILDTSDSKQFDIEKEEFQASMKYPISTFKQFMSKIANLFSSKKKAKL
What is the function of this protein?
Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop).  Involved in the establishment of the functional lipid asymmetry of the plasma membrane.  Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels (By similarity).
What are the official names of this protein?
Sphingoid long-chain base transporter RSB1.
What is the protein family that this protein belongs to?
Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL7_ECOLU
Sequence: MSITKDQIIEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAAEEKTEFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: PROT_GILLR
Sequence: MHIIFQYPIVDLRDIVSGGNGRLNDPKWPDPQERRQSFVSGFGKVKSRNLGGSDNFTGESYYCDSHSAIKFKELQHQGFSEGITTPASIFNSYRRYYNDGRFVGKVEIGLIDNLEKIIRNYPGSEGIQISSILKHYSNLEATVEDEQVKLYKAGPRLSKKYQRESTLREKHFQINPDYVQTGELTIVLTYSSHERLIVPRRSFSLEKIELPNDAGSIELFGYKLKQDGYPTKVWIIKIPANFRSKSGKHKTILRDLRMNLLRIHLEKETIKILLNAIKYKQIELEKESAEAKQVNAYFEQTSKKLFRKSRYDIKQENLLDFALQSEKSMDKGSFNSLKENITYFQDEFMLDNLGKLVGSMAVKPMLFVCSNPRDSNFIDFDKEYKDLKYNLQRAIDRDHYDIEIELSVTKDEFKDILDRYKPQFLHLSMHATVKDGLHFEDKNKAILPMSVKEFKQIIERYTKKHELKLVLISACNSKNHAKAIKEYCDFAIGTKAVFPVPAALIYSNNFYTTLFNGYQKDLEYCHSGAINAIEFNNPKFDDLDYKNKKIRVHEIPVLIKNSKYV
What is the function of this protein?
Probably a dedicated protease for substrate gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death.  Involved in defense against bacteriophages (Probable).  Expression of bGSDM and this neighboring protease is not toxic in E. coli (PubMed:35025633).
What are the official names of this protein?
Probable protease Gilli_2517.
Protein: AGAP5_HUMAN
Sequence: MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGEDLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV
What is the function of this protein?
Putative GTPase-activating protein.
What are the official names of this protein?
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5, AGAP-5, Centaurin-gamma-like family member 2.
What is the protein family that this protein belongs to?
Belongs to the centaurin gamma-like family.
Protein: RS6_ACIBS
Sequence: MRHYEIVLLVHPDQSDQVVGMVERYISQIKEADGQIHRLEDWGRRQLAYPINKIHKAHYILMNVECGQSTLDELEELFRYNDAIIRNLIIRREHAITEESLLAKSAEEKRARKAQREEAQQVAQEAE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.