PharMolix/UniProtQA huggingface dataset:
Protein: SRCN1_RAT
Sequence: MQPWQCLRRFALAWWERTAEGRARSPREEVGPRDPGGRGEPDPERSSPPMLSADDAEYPREYRTLGGGGSGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPASHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTSQGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSSPQKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPVCGSGSRSSGATPVSGPPPPAVSSTPAGQPTAVSRLQMQMHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRVVTDTLAQIRRQVDEGVWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEGTPLTPKSGNPTKGLDAPSKRNMDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKTHPGPTPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEIQKPQVKLRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGGSVPPMKVVTPGASRLKAAQGPAGSPDKGKHGKQRTEYMRIQAQQQVRVGYQAPRPLEGCTPRLCYMPLS
What is the function of this protein?
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration.  Regulates dendritic spine morphology.  Involved in calcium-dependent exocytosis.  May play a role in neurotransmitter release or synapse maintenance.
What are the official names of this protein?
SRC kinase signaling inhibitor 1, SNAP-25-interacting protein, SNIP, p130Cas-associated protein, p140Cap.
What is the protein family that this protein belongs to?
Belongs to the SRCIN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Presynapse. Postsynapse. Postsynaptic density. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions.
Protein: CAOA2_ARATH
Sequence: MAQVHLTIFIFSSIFVISSSSFIPPPHPFDPLTETELKLVRNIINKSYPIGHNHKFTFQYVGLNEPEKSLVLSWHSSPDRNVKPPPRQAFVIARDKGMSREIVIDFSTRAIVSNKIHVGNGNPMLTIDEQQAATAVVQKYKPFCDSIIKRGLNLSEVVVTSSTMGWFGETKTKRFIRTIPFYLNGSVNTYLRPIEGMTIIVNLDQMKVTGFKDRFTGPMPKANGREYRISKLKPPFGPSLRSAVVFQPDGPGFKIDGHVVRWANWEFHMSFDVRAGLVISLASIFDMDMNRYRQVLYKGHLSEMFVPYMDPNDDWYFISYLDCGEFGCGQTAVSLEPYTDCPPNAAFMDGIFPGQDGTPTKISNVMCIFEKYAGDIMWRHTEAEVPGLKITEVRPDVSLVARMVTTVGNYDYIIEYEFKPSGSIKMGVGLTGVLEVKPVEYVHTSEIKEDDIYGTIVADNTVGVNHDHFVTFRLDLDIDGTENSFVRTELVTKRTPKSVNTPRKSYWTTKRNTAKTEADARVKLGLRAEELVVVNPTKKTKHGNEVGYRLLPGPASSPLLVQDDYPQIRAAFTNYNVWITPYNKSEVWASGLYADRSQGDDTLAVWSQRDREIENKDIVMWYTVGFHHVPCQEDFPTMPTMFGGFELRPTNFFEQNPVLKAKPFNLTTIPKCTTKNE
What is the function of this protein?
Copper amine oxidase that can use putrescine and spermidine as substrates (PubMed:28383668).  Involved in putrescine catabolism in peroxisomes in response to salt stress (PubMed:28383668).  Regulates arginine-dependent nitric oxide (NO) production, a key signaling molecule regulating a wide range of physiological processes including responses to salt stress, by influencing arginine bioavailability (PubMed:28383668).  Modulates primary root growth (PubMed:28383668).
What are the official names of this protein?
Amine oxidase [copper-containing] alpha 2, peroxisomal, AtCuAO8, AtCuAOalpha2.
What is the protein family that this protein belongs to?
Belongs to the copper/topaquinone oxidase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: BM1LA_DANRE
Sequence: MPVHSREKKESNHEEMEVDFAEQEGSSSEDEDTESSSVSEDGESSEMDDEDCERRRMECIDEMTNLEKQFTDLKDQLYKERLNQVDAKLQEVMSGKAAEYLEPLATLQENMQIRTKVAGIYRELCLESVKNKYDCETQAAFQHWESEKLLLFDTVQTELEEKIRRLEEDRHSIDITSELWNDELQSRKNKKKDPFSPDKKKKPVVVSGPYIVYMLQDLDILEDWTAIRKAMATLGPHRVKTDASSKIDKLQHNARSEDGRLFYDGEWYSRGQAITIDKKDEYPTSAVITTINHDEVWFKRVDGSKSKLYVSQLQKGKYTVKHA
What is the function of this protein?
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity.
What are the official names of this protein?
Breast cancer metastasis-suppressor 1-like protein-A.
What is the protein family that this protein belongs to?
Belongs to the BRMS1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TORD_ECO24
Sequence: MTTLTAQQIACVYAWLAQLFSRELDDEQLTQIASAQMAEWFSLLKSEPPLAAAVNELENCIATLTVRDDARLELAADFCGLFLMTDKQAALPYASAYKQDEQEIKRLLVEAGMETSGNFNEPADHLAIYLELLSHLHFSLGEGTVPARRIDSLRQKTLTALWQWLPEFVVRCRQYDSFGFYAALSQLLLVLVESDHQNR
What is the function of this protein?
Involved in the biogenesis of TorA.  Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
What are the official names of this protein?
Chaperone protein TorD.
What is the protein family that this protein belongs to?
Belongs to the TorD/DmsD family. TorD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLRT1_HUMAN
Sequence: MDLRDWLFLCYGLIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANAAAKTTASNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMATGDGAKTLAIHVKALTADSIRITWKATLPASSFRLSWLRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYIICMVTMETSNAYVADETPVCAKAETADSYGPTTTLNQEQNAGPMASLPLAGIIGGAVALVFLFLVLGAICWYVHQAGELLTRERAYNRGSRKKDDYMESGTKKDNSILEIRGPGLQMLPINPYRAKEEYVVHTIFPSNGSSLCKATHTIGYGTTRGYRDGGIPDIDYSYT
What is the function of this protein?
Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases.  Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases.  Promotes an increase both in neurite number and in neurite length.  May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.
What are the official names of this protein?
Leucine-rich repeat transmembrane protein FLRT1, Fibronectin-like domain-containing leucine-rich transmembrane protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane. Cytoplasmic vesicle membrane. Cytoplasm, perinuclear region. Cell junction, focal adhesion. Secreted. Cell projection, neuron projection. Cell junction. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain.
Protein: AROE_METTP
Sequence: MKVYAVLGDPIEHSLSPVMHNAAFQAMGLQASYHAFRVKIPRLRDAILGADAMGFGGLNLTIPLKESAISVVEPDETAEAIGAANTVSFQRGIRGHNTDGIGASLALRHYGVNVRGADVLLIGAGGAARAIAYQLSKDGAEIVVTNRTPERGLALASDLGLEFRPFGEIDDLVRVSDVVINATSVGMRDGDPRLFDGSILKAEQVVFDIIYSRETELLRDARRAGAKAIDGVMMLVYQGAAAFRIWTGLDEPVDVMEAAVRAALGRLNL
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: MURA_ECO45
Sequence: MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQLGAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTTIIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUB_RHOJR
Sequence: MSAREKPSSGLVGAGLLIVDKDAGVTSHDVVARCRKLLGTRKVGHAGTLDPMATGVLVLGVERATKLLGFLALTTKAYTATIRLGQATTTDDAEGEVVASADASGVTDEEIAAQVHTLTGDIQQIPSSVSAIKVDGRRAHALIRAGEEFELAPRSVTVSRFEVVARRTEGAFVDVDVEVECSSGTYVRALARDLGIALIGVGGHLTSLRRTRVGPFTLEHARTLEQLAEEPGVSLDIDAAAQTAFPHRQVDADEAESISQGRWLEPIGIKGVYAAIDPSGHTIALLQERGRRASSVMVVRPATLR
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: SPR2J_MOUSE
Sequence: MSYQEQQCKQVCQPPLVCPPRSAQSPVLCQSAPSLVLLQSAQSPIHCQSALSHAHLSHASRNALLCNLLHHASKSAHPRANKGFSSLQNQKKRTESILHKSIATPPSSI
What is the function of this protein?
Cross-linked envelope protein of keratinocytes.  It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase.  All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
What are the official names of this protein?
Putative small proline-rich protein 2J.
What is the protein family that this protein belongs to?
Belongs to the cornifin (SPRR) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K2013_MOUSE
Sequence: MWLQQRLKGLPGLLSSSWARRLLCLLGLLVLLLWFASSGARRAAGGLHLPSWARSEPGAAEPSACLEAATRAWRGLRDRGEAVPLGPGVPALVANGFLALDASNNRLWVTPGEREPAVTPDFVPFVQLRPLNVVAEAGEAVLLLREGLLRRVRCLQLGTPGSGPAAGVPGPASASGLSAGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPVPKSFTSTLEKVGDHQFLLYSGRSTPLPSGLVHLVVVTSKKLVNRLQVAPKTQLDETVLWVVHISGPIHPQVLKSKGAKELKALQDLARKEMLELLEMPASELLQDHQYLWAQLFSPGVEMKRITDAHTPSGLTVNLTLYYMLSCSPAPLLSPSLSHREREQMEATLNYEDHCFSGHATMHAENLWPGQLSSVQQILQLADLWKLTLQKRGCKGLVKVGAPGILQGMVLSFGGLQFTENHLQFQADPEVLHNSYALHGIRYKNDHINLAVLVDAEGKPYLHVSLESRGQPVKIYACEAGCLHDPVELTSEPGGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPLFRSKEDPSV
What are the official names of this protein?
Uncharacterized protein KIAA2013.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: CBPC5_HUMAN
Sequence: MELRCGGLLFSSRFDSGNLAHVEKVESLSSDGEGVGGGASALTSGIASSPDYEFNVWTRPDCAETEFENGNRSWFYFSVRGGMPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERIRDRPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQELLNQLDQRFPENHPTHSSPLDTIYYHRELLCYSLDGLRVDLLTITSCHGLREDREPRLEQLFPDTSTPRPFRFAGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLLYHHVHSRLNSQSSSEHQPSSCLPPDAPVSDLEKANNLQNEAQCGHSADRHNAEAWKQTEPAEQKLNSVWIMPQQSAGLEESAPDTIPPKESGVAYYVDLHGHASKRGCFMYGNSFSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKASGIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYTVELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRNSRGLSSTLNVGVNKKRGLRTPPKSHNGLPVSCSENTLSRARSFSTGTSAGGSSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGSSTQKVTHRVLGPVREPRSQDRRRQQQPLNHRPAGSLAPSPAPTSSGPASSHKLGSCLLPDSFNIPGSSCSLLSSGDKPEAVMVIGKGLLGTGARMPCIKTRLQARPRLGRGSPPTRRGMKGSSGPTSPTPRTRESSELELGSCSATPGLPQARPPRPRSAPAFSPISCSLSDSPSWNCYSRGPLGQPEVCFVPKSPPLTVSPRV
What is the function of this protein?
Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins.  Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin.  Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate.  Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin.  Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.
What are the official names of this protein?
Cytosolic carboxypeptidase-like protein 5, ATP/GTP-binding protein-like 5, Protein deglutamylase CCP5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis.
Protein: GDA8_WHEAT
Sequence: PQPQPQYSQPQQPISQQQQQQQQQQQQQQQEQQILQQILQQQLIPCMDVVLQQHNIAHGRSQVLQQSTYQLLQELCCQHLWQIPEQSQCQAIHNVVHAIILHQQQQKQQQQPSSQFSFQQPLQQYPLGQGSFRPSQQNPQAQGSVQPQQLPQFEIRNLALQTLPAMCNVYIPPYCTIAPFGIFGTN
What is the function of this protein?
Gliadin is the major seed storage protein in wheat.
What are the official names of this protein?
Alpha/beta-gliadin clone PTO-A10, Prolamin.
What is the protein family that this protein belongs to?
Belongs to the gliadin/glutenin family.
Protein: PP160_ARATH
Sequence: MLRILKLSTSSRSVPLTRLWLLQLPCFCSSSSSSSSLLSVPSDDHIVRLILDQKSASGALETFRWASTFPGFIHSRSTYRALFHKLCVFRRFDTVYQLLDEMPDSIGLPPDDAIFVTIIRGFGRARLIKRVISVVDLVSKFGIKPSLKVFNSILDVLVKEDIDIAREFFTRKMMASGIHGDVYTYGILMKGLSLTNRIGDGFKLLQIMKTSGVAPNAVVYNTLLHALCKNGKVGRARSLMSEMKEPNDVTFNILISAYCNEQKLIQSMVLLEKCFSLGFVPDVVTVTKVMEVLCNEGRVSEALEVLERVESKGGKVDVVACNTLVKGYCALGKMRVAQRFFIEMERKGYLPNVETYNLLIAGYCDVGMLDSALDTFNDMKTDAIRWNFATFNTLIRGLSIGGRTDDGLKILEMMQDSDTVHGARIDPYNCVIYGFYKENRWEDALEFLLKMEKLFPRAVDRSFKLISLCEKGGMDDLKTAYDQMIGEGGVPSIIVSHCLIHRYSQHGKIEESLELINDMVTRGYLPRSSTFNAVIIGFCKQDKVMNGIKFVEDMAERGCVPDTESYNPLLEELCVKGDIQKAWLLFSRMVEKSIVPDPSMWSSLMFCLSQKTAIHVNSSLQDIIQS
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At2g17525, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: FABH_MYCBT
Sequence: MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMNL3_HUMAN
Sequence: MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC
What is the function of this protein?
Plays a role in the regulation of cell morphology and cytoskeletal organization.  Required in the control of cell shape and migration.  Required for developmental angiogenesis (By similarity).  In this process, required for microtubule reorganization and for efficient endothelial cell elongation.  In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
What are the official names of this protein?
Formin-like protein 3, Formin homology 2 domain-containing protein 3, WW domain-binding protein 3, WBP-3.
What is the protein family that this protein belongs to?
Belongs to the formin homology family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Lipid-anchor. Note=Enriched in lamellipodia.
Protein: KGUA_CLOPE
Sequence: MMNKIHKDNRGVLIVISGPSGAGKGTICKALLEKHDDIFISISATTRNPRVGEVDGVNYHFLTKEEFKQRIAEDDFLEHAEVYGNYYGTPKSSVEKMLDEGKNVILEIDIQGALKVKEKATDGVFIFILPPSMEELKQRIIKRGSETPESLMTRFKSAYKEINYVSKYNYAVVNDNVEDAVKKIEAILLAEKCRVDRLKENLLESKEDEMHEQLYD
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPS_ESCF3
Sequence: MSKTNDWLDFDQLAEDKVRDALKPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLTVHYQGKAICGVFTAEVAETKVAMVNNYARENEHPLLCTLEKA
What is the function of this protein?
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
What are the official names of this protein?
ATP-dependent Clp protease adapter protein ClpS.
What is the protein family that this protein belongs to?
Belongs to the ClpS family.
Protein: Y093_PSEF5
Sequence: MLSWAITFLIIAIVAAVLGFGGIAGTATGIAKILFVVFLVMFIASFFFGRRGRG
What are the official names of this protein?
UPF0391 membrane protein PFL_0093.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TCPG_HUMAN
Sequence: MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).  The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).  As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).  The TRiC complex plays a role in the folding of actin and tubulin (Probable).
What are the official names of this protein?
T-complex protein 1 subunit gamma, TCP-1-gamma, CCT-gamma, hTRiC5.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OMPL_SALPA
Sequence: MKSLNTLVILTSVISTSVFAGAYVENREAYNLASDQMEFMLRVGYNSDMGAGIMLTNTYTLQRDDELKHGYNEIEGWYPLFKPTDKLTIQPGGLINDKSIGSGGAVYLDVNYKFTPWFNLTVRNRYNHNNYSSTDLNGELDNNDSYEIGNYWNFIITDKFSYTFEPHYFYNINDFNSSNGTKHHWEITNTFRYRINEHWLPYFELRWLDRNVGPYHREQNQIRIGAKYFF
What is the function of this protein?
Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine.  However, the specific substrate recognized by the OmpL channel is unknown (By similarity).
What are the official names of this protein?
Porin OmpL.
What is the protein family that this protein belongs to?
Belongs to the oligogalacturonate-specific porin KdgM (TC 1.B.35) family. OmpL subfamily.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: SPED_SALEP
Sequence: MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPKLIDQTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDVNGMKHFIDHEINSIQNFMSEDMKSLYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTETERQQITAALWKEMREIYYGRNISAV
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
Protein: RIBB_DESDA
Sequence: MHQSSLSLDFFGSPHERVQKALASLRAGGGVLVVDDEDRENEGDLIFPAQTITVPQMAMLIRHCSGIVCLCLTDEYTRRLDLPMMTERNTNTQQTAFTISIEAATGVTTGVSAADRVATIQAAVAENASPENLRRPGHVFPLRAKPGGVLERRGHTEATVDLMRLAGHAPCGVLCELTLDDGSMARLPQVAAFAVAHAIPLCSVEDLVAWRHGLGEENIAISA
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: TSAD_CAMJR
Sequence: MKNLILAIESSCDDSSIAIIDKNTLECKFHKKISQELDHSIYGGVVPELAARLHSEALPKMLKQCKEHFKNLCAIAVTNEPGLSVSLLSGISMAKTLASALNLPLIPINHLKGHIYSLFLEEKISLDMGILLVSGGHTMVLYLKDDASLELLASTNDDSFGESFDKVAKMMNLGYPGGVIIENLAKNAKLKNISFNTPLKHSKELAFSFSGLKNAVRLEILKHENLNEDTKAEIAYAFENTACDHIMDKLEKIFNLYKFKNFGVVGGASANLNLRSRLQNLCQKYNANLKLAPLKFCSDNALMIARAAVDAYEKKEFVSVEEDILSPKNKNFSRI
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.