Protein: PVHA_TALVA
Sequence: MSHSDQDERIAVIGTGCRFPGGCDSPSKLWDLLKAPRDVLREIPRERFDANAWYHPDNKHHGTSNVRSAYLLDQDPAAFDNEFFNIQSSEAEAVDPQQRILLETVYDSLCEAGCTIEGLRGSNTAVYVGLMCDDWSAIVTKDTEVFPQYAATGTSRSVMSNRVSYFFDWHGPSMTIDTACSSSLVAVHQAIHTLRSGESNVAIAAGANLILSPDMFIAESNLSMLSAGGRSRMWDRDVDGYARGEGIAAVVLKRLSDAVRDNDQIECVIRATSVNQDGKTAGLTMPSGTAQAALIRSTYARAGLDISNPRDRPQFFHAHGTGTAAGDPQEARAIHEAFYSGTARNTDKLYVGSVKTVIGHTEGTAGLASLISTSLAMRHKIIPPNMHFNNLNPRLKPYYRNLEVPTKAYPWPEPAPGHPRRASVNSFGFGGTNAHAIIEEYLPSQTRDLAEHTTAVSLLTPLVFSASSEISLRSLLASYSAYLKENLTISLQSLAYTLQARRSTMPHRVAITCNTTSELISAIDGIISGQENSTIAVRHLSKPTPKVLAVFTGQGAQWARMGAKLVETSPFVSKRLKELDEALATSAAGNSPQWTLSEMILAGPALSRVAEAAISQPLCTAVQIVLVDLLRQAGVRIDAVVGHSSGEIGAAYASGLYTARDAIRAAYYRGLYSSLAKSPNGGKGSMMAVSTTHQDAIEFCELETFEGRLQVAAVNSFDSITLSGDADAVAEACEVYQDEGAFARQLKVDTAYHSSHVLPCSKPYLEAMTSAGREALPKAPSDALPWPTWYSSVRDGQEMTREDVQPQYWVDNMANPVLFSTAVEAACSDKGLFDLIIEVGPHPALQKPCLDTVEETAGARPPYVGLLGRGKDDVSAFSKALGFIWTQLGPQSVAFDNVERAASEPPVVPRELLKDLPQYPFDHSSKFLSLSRVSGFYNRSQMATHPLLGKRCYDRETNLCIQWRNILSLKEVPWLTGHQIQGLTVFPAAGFVSMAIEAIVALAKDSTIGLLSLENVNIGRAMAFQDDSSRVEVLFDMRIIAQTPHEIAAEWASYSGDPHDIKTVLTLNASGVVRATLAENNASAEPDVLPALDVIDNNDLSPVDTERFYKFLRKLGYNYSWPFYGTKSIQRKAGFSTGMLEDQSGDEWQDQLLVHPGMIDTALQTAFAAFCCPGDERLWSLHVPTRFKSLVINPFFTARGIGKQRMLKFVSTAAAVKQGKIAAELYLQSEHEGQTHTFLQAEGLEIVPLAAAVPDNDTVLFSRFDYKLACADGETAAILDTPLSQDAIDDVINAERVAFYHLYNVVKSITPGEEASALPHYQQFLSWARNVVENVLRGDNKYVPASAAQDSASDIASLLTGLPFRFDKNGEVSLAEAIGKNLISAIRTSSTVFQAEDRNLPAELYEKAIGFDTGNQCLANMIASISHRYPRMNILEVGSQVGSSTEAILSQLDTAFDTYTYTNISDDSFGLAEEHFTAYGDRINFKTLDITQSPTSQGFALGEYDLVVASNVISSGSDMTESLTNLRALLKPGGFAVILEPVDNDCLRLGLALGCMPDRSPPLGLPQWNSLLSETGFSGTDTISPRSHGAVPGVVFCTQAIDDRIKMLRSPLSNISCLPGLEAPELAIVGRGQSSELQNLCGELSDLLSSAFPKVTFVDSVEQVTAETIPTTSAVIMLAELGESPWASLNPVKLEGIKNIYRQARNLLWVTSGADSKDPYSNISLGIGRAMQFEYPHLSIQALDVDTISENTAKIIAEHLLRLGTLSTWKEDPEQPTMLWSMEPEVWIKNDMPIIPRLCPYTPGNDRYNTTRRTVRNQVIPRDTHLALTNDNGAWEVQVTSPLHQAPKIPYATDTKQVRVTDVLLSTLGIIPGTMLMLCTGQDTSTGEALLALSPIAETLVQVPRSWTTGIDNAEPRDALGAVAANIVAKLMAKSAFRGDVLIVHDPHPAVAHELAIIANKGAFTIHFTTASAQVSIEQGWHHIGSRFSASKVKSLLPINANKLLDLSKSSADGISAHILSSLPRGCRVVDMSHIMGNTTELQSWVSEDEVATVLQESVTEVLRSDRYTNLVNNVPLVSLESISEPTHHASFAIADCSVPAVTARVRAVDDGIIFRGDNTYLLVGLTGEIGRSLCKWMAERGARHIVLTSRTPKEDVVFSSAMKALGAVVKYLPMDVRSRDSIHACYAMIQNTMPPVAGVANGAMIIHDMVFDNMSFEVMDKVLAPKVVGSQLLDELFYDTPLDFFIFFSSMTAVMGNSGQANYLAGNMYMNALAAQRKERGVAGSSINISSVIGVGYVERSDQLDEEYFLNMGYRPMSEQDLQVSFAEAIVLGKPGSSEIAELSTGINSTLNGQSIGKWLQDIKFSHMMMHESNDNAGMGPGASAAPLKVQLSEAKSKEDIISIIKEVFLARLRRILSIPADKNINEDVTLVEQGVDSLMAVEVRSFFNKELDVDIPVLKILGDISINGIIKQVVELLPAAVYDLPEETPQTLSKNPAPTPVKAPVSAPSTPAAASQPVLTDSTASSSRDSDDDQASSNSTSYETSKDASREDSEVDETPLESPVNTPNVMSKPSASSQLLEKKQLLEVDALIASSRPETLAPMSHGQEGFWFLQDYLPDKTVFNTSVMLKLEGEISVETLSQALQMVARRHEILRTRFFSADDDGEQKVMQAIAANSSLELETKQITSGNEAQVEFTRFNKHVFDLANGEAARVLLLSLSKTEHFLMAGMHHIYLDGYSFSIFFNDLNTAYTSKRLPPLPSNSQYRSFVEQERERYESGEFDETIAHYRETLPKDLAPIELLPFARGTTRREVNNYDQTESKMRIDRPLADKIRQLARNNRSTSFHVFLAAFQALLFQLLPESDDLIIGMGDANRDDKKYLNSIGYFFNLLPLHFSRFKSGTKIADLVQDSRSAVREALERPHVPLSILLDELDVPRSNKHTPLFQVCIDHRQVLQEQSNWGGCRVSDEQWHDAGTGFDISLQITEFNTDASLSLRLQKPMYTEEHTNMLLRSFVAVLEHMADVPTDNMVEDIPSWSELDIQKALTVGKGREFHSRWDSNPPTVMHRIHEMITVHGSTTALKDGHGSTLSYEQMGRRIAAISAALIEKGIARGDVIGVFQEPSVDWICSMMAIFNIGATYMALDQRLTLPRLATIVQTAKPAAILTDSFTSSQVTDIGASAITTVLVSHLASSVNTKPINAARAEDVAVVLFTSGSTGVPKGMRMTHANLVFSTDSISGAFNVTQESMVLQQSPFSFDPSLCQTLVALTNGAALYVVPSRSRGDPMAVTKIMAEEKVTFTVGTPSEYAMLLEYGADNIRQCHAWKCAAWGGEQMPHGLAKQLAAANLPGLKAHNVYGPSETTMLSHFHLVNPAEIEGNGYIPVGAGFDGYKYCIVDHQMRVQPIGVPGEIIIGGPAVVAGYLNNQQLTDTKFLADSFFGTNGKVYRSGDLGRMLEDGTLVVEGRLDGDDLIKLRGFRIELEEIEKAIVKQADGTLGDAIVSLRGEGDAQFLAAHVTLSADLSPPAKQKLISALQRLPLSSYMIPSVFGVIKAIPKTAHDKVDRKAAKELPLPSADDENSLAVHGIDGGDDSVLSGTERQLGTLWRQVIPVYVGSLASTSDFFLAGGNSLLLVKLQALLRTEFGATPKLMDLMGASNLAAMADAVQKEVDSSLTRDGIDWDLETRPPVALQHKLSGFISSARTNTTRPDASRFNVLLTGATGQLGRHVLSQLVTNGKTSRVICLTRQPDKIEANDKVTTLRGDVSEPNFGLSEQEYQQLATETDVIMHCVANRSFWDRYEVLQPVNVSAVKSLVGLIADSGRIIPLHFMSSGAVSHYYNLGTSPPRDGSDGYVASKWAAEGFLRRIAAETSIPIYIHRPSSVDGDALGSPQEREAVTDQLMGIVNSMEIQPEFGGVDGTLDIAPVDDMAQSLAELVLKSITEAAETDGSEKNLIQEFKHKAALQVYARDFAARLESEGQHAQFPKMPILEWFGQAKAAGFSYIIAAQELVMTSGLDAITTRR
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of varicidin A, an antifungal natural product containing a cis-octahydrodecalin core (PubMed:30609896).  The PKS module of pvhA together with the enoylreductase pvhC catalyze the formation of the polyketide unit which is then conjugated to L-isoleucine by the condensation domain of the NRPS module (PubMed:30609896).  Activity of the Dieckmann cyclase domain (RED) of pvhA results in release of an acyclic tetramate (PubMed:30609896).  The cytochrome P450 monooxygenase pvhE then catalyzes the oxidation of the C21 methyl group to a to carboxylate group (PubMed:30609896).  The methyltransferase pvhD then further methylates the pvhE product (PubMed:30609896).  The Diels-Alderase pvhB is able to catalyzes Diels-Alder cycloaddition using both pvhE and pvhD products as substrates to form the decalin ring, yielding varicidin B and A, respectively (PubMed:30609896).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase pvhA, PKS-NRPS pvhA, Varicidin biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.