Protein: ACRS2_ALTAL
Sequence: MEKDTPVAIIGVSYRAPGIGGKGLWDYLAEAKSAWTKVPPERFEHFAWYKAGEKKTGVFANEGAHFVDNVFDFDAAFFNMRADEARCADPSHRFMLEVALEAAENAGQSLLDLSGKKIGVFVGAGQHEYSHRVSDDEYAIQTFTATGVAPCMAANRLSYFFDIDGPSVVLDAACASSAYAVDMAVKAIRNGDCDGAFVGAAALNLSPSGWLVLDQSGTLSDIGRSFSYDAKASGFGRGEGAACLLIKRLEDAIRDGDPIQALIRGTACSHSGRSEGITMPSRRAQEKLIWDVHNSAGLDPSNTAVVEVFSRGHGTGTAVGDPIEAGAFTSVLARNRTAANPIYIGSLKSNFGHLEGASGVLAMIKAVLMVRNGVVLPTAGFERINEAIDNYEKIKVPTTPLPWPENEPRRCLVTNFGFGGSSSAVIIDRSPYLHALDGYEDLADIKIPRLNGSSGRSESGSGQSQRLFVFSAKTRDSLTAYLASFHEYLLKAQESHEFLKDLSYTLGQRRTHHAYRASVVANSISDLRKEIPNLKPSKIRQRSVIFVFTGQGAQYARMAYNLRQFTVFAETLEKAETQLNKMGASWSLTEELNKLTDTRINDAEISQPACTAVQLAMVALLQSWGVVPNMVTGHSSGEIAAAFTAGLLTFQEAIAISYFRGQSAVQLSAAQHEYKKGAMLALGVGSEDALKIIDEHAQGYATVAAINSPRSVTISGDKTAIENVRKAADMQGLFARMLKVEVAYHSRHMEQVAASYLKDIEPYFQGKAIPAENSGACRPVFVSSVTGQIIDAVDSSYWIKNLVQPVLFADAIKEVLTHEDQGKSQSIHGSSKTLVEIGPHAALKNPVKQTAELLSSERAWNLASLNYLPSLLRGTNDVHAILELARALFDLGASVELSGVNGTNKHNARVLTELPSYAWDRSYYELRPRVTHDKQFPGEEYHALIGRKAPSNAAQENTYRQVFTLDEMPWIRDHVVSGVTVFPMTGYMSCAIEAARRVDSAAPAAFLITDFHVVQSLEIHEEETVDLTTKLKPAATGEGTFSSKVWSFEVVSWSEANGWTRHCWGKIEPEIADLTLATPTFEASLPLVTSMAGVIEHDMDNEYHNIELRGTKYGPSFRNNVKFYEGKNYTVLEHRIRDLGDALKIPVYRGSPVSVDPPTLDSFLQGAGPFQYDGSGRRLTQMPDYISRFRISNNITSEPNHRLDVVMRRLDYDDKGGRMHVSVAVFGRGSDDQFTPIAEWESFTFRTVSSADDQSASVPDNWSWELLPRYDLISKDTLRDRLLESVGDLGEEEDVRMSKLDAVGCYYIEKALKDTVTLDYSKLPTHLARFVHWGRNVLKEYEVNFESEPTSLLEDVRNLDAQGELLCLMGENLVDILAGRIEPLEVMLTDGRLMRHYEADVANAHLSKIIGYLTENMADLEPWQRILEIGGGTAGTTLPVLEGLSRNRDEPGCLDYTFTDISSGFFEMASKKLSRWSQQITYKRLDITQDPAMQGFTQESYDVVVAANVLHATADMVTTMTHVRSLLKPGGKLILLEATRHPPWLLPFTLLPDWWAAKDKYRDHKQGPMMPAVVWNDLLLDSGFSGVDVVIPTNYRTDNPLMNVVCSTRIGKQDDSETITICGPLVDDTEVNFAQSVARSISKELGCPTEIKRFADIKPDDESYYILLDSKHESVFQNFNPGKFECLKSLLLRNKGLLWVTAKGCSPDAKMIQGMVRTVRLEVEPKNLMLLDNVPSTPEGLSGILKLAARLRDPEVSRDQDMDFAWHDGAIHLPRMRQLKDLKEQFSVEEGVAFRRTQNLRDNSDRGLEMTIQAAGSPDTIYFRRTDPYEVSEDEVLVRVEAAGVGHRDFEVLMGSIPWAPPGYEGAGKVLKIGSQVSHLREGDDVFFLTPEASAFATEVKLASWLVARIPKNMTVTDAAACPLGYCLATLAFRTARLTKNETVLIHSAASSVGQACILLAQDIGARIYVTAGTEDKRDYLHQALGIPRDHIFSSRTAEFRDSLLCKTNNRGVDVVVNSLSGELLTETWAVIAAFGRFVEIGKKDAFLNNSLPMRPFNNNVTLSAIDLRDLYHHRPDDVRSVWNEVVNLLQRKQVRPVDSASVVSISHFSAALRILRSRDHIGRLVVTLGDDNSVMAETALRPSQVSLKDDATYLVAGGTRGIGLDLAYWMIEHGARNIVLLGRSGASGPEAQKILNKFRNTKVCVRAVACNVGDRDELQNALESIKDLPAIRGVVHSALLLSDKLFVNASYEDWVINTTPRVAGAWNLDDLLPTDLDFFVALSSFNGDTGHTGQAIYAGTAGFYNAFSQYRNNRGQYTVSIGLPVVLDVGYVADHDLRGGLLNDSLSAGVTMADIRATFNCILLGPSSPFVRNGRASTFKVYINGQPVQDVTWNYFHPAHSKVRLTNANRNKVKATSGGAEISSASWTTAEDPLTGLIEALIAKVSAMTMMEREDVLPDAPLASYSLDSLVSVELRNWIRRETTAEMTLVSITKAENLRALAVNILAQRKAG
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the host-selective toxins (HSTs) ACR-toxins responsible for brown spot of rough lemon disease by the rough lemon pathotype (PubMed:22835272).  ACR-toxins cause uncoupling of mitochondrial oxidative-phosphorylation similar to that of classic protonophore (PubMed:22846083).  The structure of the major form of ACR-toxin (ACR-toxin I) consists of an alpha-dihydropyrone ring in a 19-carbon polyalcohol, a typical polyketide structure.  Minor toxins were characterized as having a pyrone ring with polyalcohol side chains different in length and showing weaker toxicity (PubMed:22846083).  The highly reducing polyketide synthase ACRTS2 has all necessary enzymatic domains for multiple cycles of condensation and beta-keto processing (PubMed:22779742).  The cytochrome P450 monooxygenase ACRTS1 has also been shown to be essential for ACR-toxin biosynthesis, however its exact role in the pathway has not been elucidated yet (PubMed:22779742).
What are the official names of this protein?
Highly reducing polyketide synthase ACRTS2, HR-PKS ACRTS2, ACR-toxin biosynthesis protein S2.