PharMolix/UniProtQA huggingface dataset:
Protein: BIOB_HYPNA
Sequence: MTSSDLTPRQNWTREEIAAIYDLPLDQLFARALAVKAAHWADGAVQKSQLLSIKTGGCAENCGYCSQSASFKTGLKAEKLLPVEEVVDAARRAKANGADRFCMGAAWRSLKDRDLPKVAEMISAVKAEGLETCVTLGMLEEGQAEALKEAGLDYYNHNLDTSREYYSTVVTTRTFDDRIETLGRARQAGIKLCCGGILGMGESRSDRVGLIHELSLLSPHPESVPVNKLVPIEGTPLANSEELDTLELARAIAVCRIVFPKSWVRLSAGRETMSAEGQALCILAGANSIFVGDRLLTTANPAMDKDARLLESVGGGCSKC
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: SYRC_CAEEL
Sequence: MSANKELQQGYSDYSAASDQAALLNRLITAMQKGELTDELLEHIPELGDAKKLNDKLKYRKSILEKSIAEQAAKNKKNGVKATSTSSPSSSTSAPAEKKAKKDGKTGGAPPKQAKKVDYVTVEDYGSSIFGRLQSLFKKAIEDAFPGLDVPLLLAETPNPQFGDYQCNSAMPIAAKLKANKINKRPGDVAKEIQAKLPTKIDFVEKIDVMPAGFINIFLNTDYLRRQISLLASEGVKLPKLTRKRVLVDFSSPNIAKEMHVGHLRSTIIGDSICRLFEAVGFDVLRVNHIGDWGTQFGMLIAHLYDRFPDFLKKLPDISDLQAFYKESKKRFDEDEQFKKRAYEYVVKLQSHDGDIVKAWNTICDVSKKYNQIVYNYLDIKIKDVGESFYQDKMIELVKWVKTNKPDMLREEDGRQIMFPTGCDIPLTVVKSDGGFTYDTSDLAALKYRMLEEKCDWNIYVVDSGQSLHLETVYAAGRDFGWYDESIQRVEHVAFGLVLGDDKKKFKTRSGETVRLLDLLSEGVKRATEKLIEKGRETAMSEEQLVAARDAVAFGCVKYADLSHTRTQDYVFSFDRMLEDRGNTAVYLLYAYTRIQSIFEKDEVKNVDLVKYIASTPTLPLDHPGEFKLAKQLLKLSDCVLLVLDSLMLHQMCDYVYQLATLFHDFYNECYVIENKEGEKPFVHMHRLALCDVTRKVMSTCFKILGLREVNKM
What is the function of this protein?
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.
What are the official names of this protein?
Probable arginine--tRNA ligase, cytoplasmic, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol.
Protein: COG6_BOVIN
Sequence: MAEGSGEVVVVPATGAANGLNNGAGGTSAQTSNPLSRKLRKILDTRLDNDKDMLEALKALSTFFVENSLRTRRNLRGDIERRSLAINEEFVSIFKEVKEELESIHEDVQAMSSCCQDMTSRLQAAKEQTQDLIVKTTKLQAESQRLEIRAQVADAFLSKFQLTSDEMSLLRGTREGPITEDFFKALGRVKQIHNDVKVLLRTNQQTAGLEIMEQMALLQETSYERLYRWAQSECRTLTQESCDISPVLTQAMEALQDRPVLYKYTLDEFGTARRSTVVRGFIDALTRGGPGGTPRPIEMHSHDPLRYVGDMLAWLHQATASEKEHLEALLKHVTAQGVEENIQEVVGHITEGVCRPLKVRIEQVIVAEPGAVLLYKISNLLKFYHHTISGIIGNSATTLLTTIEEMHLLSKKIFFNSLSLHASKLMDKVELPPPDLGPSSALNQTLVLLREVLASHDSSVVPLDARQADFVQVLSCVLDPLLQMCTVSASHLGTADMATFMVNSLYMMKTTLALFEFTDRRLEMLQFQIEAHLDTLINEQASYVLTRAGLSYIYNMVQQHKVEQGPLANLPNLDSVALKAAMVQFDRYLSAPDNLLMPQLNFLLSATVKEQIIKQSTELVCRAYGEVYAAVMNPVNEYKDPGSILHRSPQQVQTLLS
What is the function of this protein?
Required for normal Golgi function.
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 6, COG complex subunit 6, Component of oligomeric Golgi complex 6.
What is the protein family that this protein belongs to?
Belongs to the COG6 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein.
Protein: SAC1_XENLA
Sequence: MALAYENLKLHITPEKFYVEACDPGVEDVLTIDRVSTEVTLSGKKDIPPSAITRAIYGILGTIRLVAGMYLIVITRRKKVGDLLNHSIWKATDFDIISYKKTMLHLTDSQLQDNKAFLGMLSHVLSVDGFYFSVSYDLTHTLQRLANTSPEFQEMSLLERADQRFVWNGNLLREFSAQPEIQKFAIPVVHGFIAIHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGNKASFVQTRGSIPFYWSQRPNLKYKPKPQISKAVNHMDGFQRHFDSQVISYGKQVVLNLVNQKGSEKPLEQEFSQMVSGLGNGMVRYIAFDFHKECSRMRWDRLQILVEQVAETQDEFGYFLVDTEGKVVSQQDGIFRSNCMDCLDRTNVVQSLLARRSLQYQLQRLGVLHVGQRIEEQIQFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTQWGLLMDGWNSLIRYYKNNFSDGFRQDSIDLFLGNYSVEEAYSTSPLHIQTDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGTASIGTGAIIMYNGKDFVDAPKLVQKEKMD
What is the function of this protein?
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2).
What are the official names of this protein?
Phosphatidylinositol-3-phosphatase SAC1, Phosphatidylinositol-4-phosphate phosphatase, Suppressor of actin mutations 1-like protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: RIR1_CHLPN
Sequence: MVEVEEKHYTIVKRNGMFVPFNQDRIFQALEAAFRDTRSLETSSPLPKDLEESIAQITHKVVKEVLAKISEGQVVTVERIQDLVESQLYISGLQDVARDYIVYRDQRKAERGNSSSIIAIIRRDGGSAKFNPMKISAALEKAFRATLQINGMTPPATLSEINDLTLRIVEDVLSLHGEEAINLEEIQDIVEKQLMVAGYYDVAKNYILYREARARARANKDQDGQEEFVPQEETYVVQKEDGTTYLLRKTDLEKRFSWACKRFPKTTDSQLLADMAFMNLYSGIKEDEVTTACIMAARANIEREPDYAFIAAELLTSSLYEETLGCSSQDPNLSEIHKKHFKEYILNGEEYRLNPQLKDYDLDALSEVLDLSRDQQFSYMGVQNLYDRYFNLHEGRRLETAQIFWMRVSMGLALNEGEQKNFWAITFYNLLSTFRYTPATPTLFNSGMRHSQLSSCYLSTVKDDLSHIYKVISDNALLSKWAGGIGNDWTDVRATGAVIKGTNGKSQGVIPFIKVANDTAIAVNQGGKRKGAMCVYLENWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLEKKGMWTLFSPDDVPGLHEAYGLEFEKLYEEYERKVESGEIRLYKKVEAEVLWRKMLSMLYETGHPWITFKDPSNIRSNQDHVGVVRCSNLCTEILLNCSESETAVCNLGSINLVEHIRNDKLDEEKLKETISIAIRILDNVIDLNFYPTPEAKQANLTHRAVGLGVMGFQDVLYELNISYASQEAVEFSDECSEIIAYYAILASSLLAKERGTYASYSGSKWDRGYLPLDTIELLKETRGEHNVLVDTSSKKDWTPVRDTIQKYGMRNSQVMAIAPTATISNIIGVTQSIEPMYKHLFVKSNLSGEFTIPNTYLIKKLKELGLWDAEMLDDLKYFDGSLLEIERIPNHLKKLFLTAFEIEPEWIIECTSRRQKWIDMGVSLNLYLAEPDGKKLSNMYLTAWKKGLKTTYYLRSQAATSVEKSFIDINKRGIQPRWMKNKSASTSIVVERKTTPVCSMEEGCESCQ
What is the function of this protein?
Provides the precursors necessary for DNA synthesis.  Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
What are the official names of this protein?
Ribonucleoside-diphosphate reductase subunit alpha, Ribonucleotide reductase.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase large chain family.
Protein: PGK_DESDA
Sequence: MPVTKMQDLDLGGKTVVIREDLNVPMKDGIITNDKRIRAALPTIQLALEKGAGVIVLSHLGRPTEGQYDQQFSLAPVADRLAQLLGQPVTLAKSLDEAKTAPGQVTLLENVRFLPGEKKNDPELAAKLAGLGDVYVMDAFGSAHRAHASTEGAVRTAAVACAGPLLQAELEAFDKVLDNPARPVVAIVGGAKVSTKLTLLENLLEKVDVLIVGGGIANTFLAAAGYMVGKSLYEEDLLPEAQKIMALAKTLNKELPLPVDVITAEELAPRQQTMLHAVGDVPGDQMILDIGPETLTLYEKFLSKAATVVWNGPVGAFEIEPFGDGTKALAEYLSDSKAFVVVGGGDSVAAVEKYGLADRMGYISTGGGASLELLEGKKLPSVAALEDRA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPG_AERHH
Sequence: MAGAKEIRNKIGSVKNTQKITGAMEMVAASKMRRAQDRMSASRPYAETMRKVIGHIAQGNLEYKHPYLIEREVKRVGYIVVSTDRGLCGGLNINLFKAALNDMKQWSAKGAKVDLALIGNKASNFFERHGAKVKAHVAGLGDNPSVNDLIGSVKVMLKAYDNGEIDRLYLVYNKFVNTMVQQPRVDQLLPLPVTEDSKLAKKHHWDYLYEPDPKQLLDTLLIRYVESQVYQGVVENLASEQAARMVAMQAATDNAGNLINDLQLVYNKARQASITQELTEIVSGAAAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LEUC_BURM9
Sequence: MAQTLYDKLWNSHVVHTEEDGTALLYIDRQLLHEVTSPQAFEGLKLAQRPVWRISANLAVSDHNVPTTDRSHGIADPVSKLQVDTLDANCDAYGITQFKMNDVRQGIVHIIGPEQGATLPGMTIVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQTLLQKKSKNMLVKVEGQLPRGCTAKDIVLAIIGQIGTAGGTGYAIEFGGSTIRALTMEGRMTVCNMAIEAGARAGMVAVDDTTVEYLKGRPFVPTGAEWDQAVEYWKTFRSDEGAQFDRVVELDAAQIVPQVTWGTSPEMVTSIDGRVPDPEREKDPVKRDAMERALAYMALAPNTPIEAIKVDKIFIGSCTNARIEDIRAAAYVVKKLNRRVAPNVRLAMVVPGSGLVKAQAEREGLDKVFTEAGFEWREPGCSMCLAMNADRLEPGERCASTSNRNFEGRQGQGGRTHLVSPAMAAAAAIEGHFVDIRRLG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RS4_CERSK
Sequence: MTKRTSAKYKIDRRMGENIWGRPKSPVNKREYGPGQHGQRRKNKLSDFGTQLRAKQKLKGYYGDLTEKQFRKIFAEAERVKGDTGEMLVGLLERRLDAIVYRAKFVPTIFAARQFVNHGHVTVNGQRVNIGSYRCKEGDVIQVREKSRQLALVLEATQLAERDVPDYIEVDYSKMTATFVRTPGLGDVPYPVQMEPNLVVEFYAKN
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: GIT2_CANAL
Sequence: MASRDLPHSLNDLAFGWIKHLKEEIIINKNSQQLVDEDFQPDEDVTKETKVKLNNLWPAFASGAGLFADGYVNNSIGIVMACLKILYGDEFTKSNAISNIGSIGFVGTVVGQLSFGYISDRVARKGGMMTANIMLIAFTLLCAVGSWGTTIQGFFACLTVWRFCLGVAIGAEYPTSSVIASEFANQLPAGKRNRYFIWFTGFMIDFGFVVSAFVPFVLLWIFTEKHLRALWRVSIGLGAILPTALFFIRLKMKDSTSFEKLHMKNVRYRDYPWWLIVKFYWFRLTIVSMIWFIYNFSVYSFGTFNAIILGQIIPDAPLWQQWGWSVVFNLFYIPGSFLGAFSADYLGPRLTLAIGVGLQGIIGFIMSACLNGLRKQVAAFTVVFGIFATLGEFGPGGNIGLLASKTSATPIRGQYYGIAAAMGKIGAFVGTWIFPAIQRRYASKTNPDLELQVPFYLSSGLCIFSALLTFFLCPHVGQDAINREDKEFVEYLRKNGFDVSKLGEDSSSVDVDVVKDTDSAEKISETIEVGQKLA
What is the function of this protein?
Probable glycerophosphodiester transporter (PubMed:24114876).  Does not possess detectable glycerophosphoinositol (GroPIns) transport activity (PubMed:24114876).  Might be involved in the uptake of glycerophosphocholine (GroPCho) (PubMed:24114876).  The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:24114876).  This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:24114876).
What are the official names of this protein?
Glycerophosphodiester transporter GIT2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UVRB_BEUC1
Sequence: MRPVTDLQRRVFPFEVISDFTPSGDQPDAIAQLTARLQAGEKDIVLLGATGTGKSATTAWLIEQVQRPTLVMAPNKTLAAQLATEFRELLPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSINDEVERLRHSATNSLLTRRDVVVVASVSCIYGLGTPQEYVDRMVRLRVGMQIERDDLLRQFVGMQYTRNDLSFQRGTFRVRGDTVEIIPVYEELALRIEFFGDEVEAIHTLHPLTGDVVRAEEEMYLFPATHYVAGPERMERAIAGIEVELEDRLAELEGGGRLLEAQRLRMRTTYDIEMMRQIGTCSGIENYSRHIDGREPGSPPHTLLDYFPEDFMLVIDESHQTVPQIGAMYEGDSSRKRTLVEHGFRLPSAMDNRPLRWEEFLERIGQTVYLSATPGPYELGQSDGVVEQVIRPTGLVDPEIVVKPTKGQIDDLLAEINARAERDERVLVTTLTKKMSEDLTDYLLERGVRVRYLHSEVDTLRRVELLRELRTGVFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSGTSLIQTIGRAARNVSGQVHMYADSVTPSMALAIEETNRRREKQVAYNTERGIDPEPLRKRIGDITELLAREDIDTKELLAGGYRQAGSKAPVPRKAGGDGSMRERLAGAATADLAELIQELTDQMHVAAGELQFEVAARLRDEISDLKKELRQMSAASA
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_ENT38
Sequence: MSLSVEAKAKIVSEFGRGTNDSGSTEVQVALLTAQINHLQGHFAEHKKDHHSRRGLLRMVSQRRKLLDYLKRKDVARYTALIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: PTX3_HUMAN
Sequence: MHLLAILFCALWSAVLAENSDDYDLMYVNLDNEIDNGLHPTEDPTPCACGQEHSEWDKLFIMLENSQMRERMLLQATDDVLRGELQRLREELGRLAESLARPCAPGAPAEARLTSALDELLQATRDAGRRLARMEGAEAQRPEEAGRALAAVLEELRQTRADLHAVQGWAARSWLPAGCETAILFPMRSKKIFGSVHPVRPMRLESFSACIWVKATDVLNKTILFSYGTKRNPYEIQLYLSYQSIVFVVGGEENKLVAEAMVSLGRWTHLCGTWNSEEGLTSLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYVS
What is the function of this protein?
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.
What are the official names of this protein?
Pentraxin-related protein PTX3, Pentaxin-related protein PTX3, Tumor necrosis factor alpha-induced protein 5, TNF alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14.
What are the subcellular locations of this protein?
Secreted.
Protein: NUMB_DROME
Sequence: MGNSSSHTHEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL
What is the function of this protein?
Required in determination of cell fate during sensory organ formation in embryos (PubMed:2752427).  Restricts developmental potential and promote maturation of intermediary neuronal progenitor (INP) cells probably acting as an antagonist of Notch signaling (PubMed:24550111, PubMed:28899667, PubMed:18342578).
What are the official names of this protein?
Protein numb.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cell cortex. Cytoplasm. Note=In larval brain, shows asymmetric localization and asymmetrically sized divisions in type II secondary neuroblasts.
Protein: RL4_FRATM
Sequence: MDLNIKSLAGQEAGSLGVAEGVFAADYNEALIHQVVVAYMAGARQGTKAQKTRSEVSGGGAKPWRQKGTGRARAGTIRSPIFRKGGVTFAAKPKSYKQKVNRKMYSGAVKSILSELLRLGRMTIVEELKLETPKTREFKSVIDSLGVKDVLFVVGVEEFSENLYLSSRNLKNVAVCDSVEINPVSLVCFENVVLTKKAIKEIEEKLV
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: CD59_RABIT
Sequence: MTSRGVHLLLRLLFLLAVFYSSDSSLMCYHCLLPSPNCSTVTNCTPNHDACLTAVSGPRVYRQCWRYEDCNFEFISNRLEENSLKYNCCRKDLCNGPEDDGTALTGRTVLLVAPLLAAARNLCL
What is the function of this protein?
Potent inhibitor of the complement membrane attack complex (MAC) action.  Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
What are the official names of this protein?
CD59 glycoprotein, MAC-inhibitory protein, MAC-IP, Membrane attack complex inhibition factor, MACIF, Protectin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: FPG_RHIEC
Sequence: MPELPEVETVKRGLAPAMEGARVTRLELRRRDLRFPFPDALAERVSGRTIVGLGRRAKYLLVDLDDGNTLISHLGMSGSFRIEEGAASAMPGEFHHARSKDEKHDHVVFHLEGGGGPRRVVYNDPRRFGFMDIVGRADLSAHPFFRDLGPEPTGNELGATYLAERFRDKAQPLKSALLDQKNIAGLGNIYVCEALWRSHLSPIRAAGTLVTSGGRPKQQLDLLVASIREVIADAIAAGGSSLRDHIRADGSLGYFQHSFSVYDREGQACGTPGCGGTVARIVQAGRSTFYCAACQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: NDUF5_RAT
Sequence: MLRRVVLSRLYARLGGPAVSAGRGGRRGVASSVPPSGSTSPRALNIFDRELKRKQKNWAARQPEPMKFDYLKEEIGSRIADRVYDIARDFPLALDIGCGRGYIAQHLNKETVGKIFQTDIAEHALKNSIETDIPTVNILADEEFLPFPENTFDLVVSSLSLHWVNDLPRALEQIHYVLKPDGVFVGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYSNEDGSIPATYQIYHMIGWKYHDSQARPAERGSATVSFGDLARLNDTMSQGKK
What is the function of this protein?
Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages.  Acts by mediating hydroxylation of 'Arg-111' of NDUFS7.  May also have methyltransferase activity.
What are the official names of this protein?
Arginine-hydroxylase NDUFAF5, mitochondrial, NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5, Putative methyltransferase NDUFAF5.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Note=Peripherally localized on the matrix face of the mitochondrial inner membrane.
Protein: RS20_LYSSC
Sequence: MPNIKSAIKRVKVNEKANIANSQAKSAMRTTVKKAENAVAENAENKQELLQAAFKSLDKAASKGLIHKNAAARKKSRLAKKA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: PHOSP_NIPAV
Sequence: MDKLELVNDGLNIIDFIQKNQKEIQKTYGRSSIQQPSIKDQTKAWEDFLQCTSGESEQVEGGMSKDDGDVERRNLEDLSSTSPTDGTIGKRVSNTRDWAEGSDDIQLDPVVTDVVYHDHGGECTGYGFTSSPERGWSDYTSGANNGNVCLVSDAKMLSYAPEIAVSKEDRETDLVHLENKLSTTGLNPTAVPFTLRNLSDPAKDSPVIAEHYYGLGVKEQNVGPQTSRNVNLDSIKLYTSDDEEADQLEFEDEFAGSSSEVIVGISPEDEEPSSVGGKPNESIGRTIEGQSIRDNLQAKDNKSTDVPGAGPKDSAVKEEPPQKRLPMLAEEFECSGSEDPIIRELLKENSLINCQQGKDAQPPYHWSIERSISPDKTEIVNGAVQTADRQRPGTPMPKSRGIPIKKGTDAKYPSAGTENVPGSKSGATRHVRGSPPYQEGKSVNAENVQLNASTAVKETDKSEVNPVDDNDSLDDKYIMPSDDFSNTFFPHDTDRLNYHADHLGDYDLETLCEESVLMGVINSIKLINLDMRLNHIEEQVKEIPKIINKLESIDRVLAKTNTALSTIEGHLVSMMIMIPGKGKGERKGKNNPELKPVIGRDILEQQSLFSFDNVKNFRDGSLTNEPYGAAVQLREDLILPELNFEETNASQFVPMADDSSRDVIKTLIRTHIKDRELRSELIGYLNKAENDEEIQEIANTVNDIIDGNI
What is the function of this protein?
Essential component of the RNA polymerase transcription and replication complex.  Binds the viral ribonucleocapsid and positions the L polymerase on the template (By similarity).  May play a role to prevent the establishment of cellular antiviral state by binding to host STAT1 in the cytoplasm.  This activity is not as strong as that of V and W.
What are the official names of this protein?
Phosphoprotein, Protein P.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: SYS_STACT
Sequence: MLDIKLFRNEPDYLKGKVKLRGMDPKVVDEVLELDGKRRELIGKAEEMKAERNRVSNEIAEKKRNKEDADDVIAEMRKLGDDIKEVDTELNEVDEKLQYRLSTIPNVMHDDVPEGDSDEENIEVKKWGTPRQFDFEAKAHWDLIEELGMANFDRAARVSGARFVFLTNEGAQLERALMNYMLTKHTTQHGYTEMMVPQLVNANSMYGTGQLPKFEEDLFKVEKEGLYMIPTAEVPLTNYYREEVLSADQLPGKFTAQSACFRSEAGSAGRDTRGLIRLHQFDKVELVRFEKPEDSWDALEQLTSNAEAILEELELPYRRVILCTGDLGFSSSKTYDLEVWLPSYDEYKEISSCSNMTDFQARRANIRFKRDKDAKPELVHTLNGSGLAVGRTFAAIVENYQNADGSITIPEALVPFMGGKTKIGPATK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_HELAH
Sequence: MFGLKQFYQNEVKVKLAQELDIKNPMLLPKLEKIVISVGAGAHAKDMKIMQNIAQTISLIAGQKAVITKAKKSVAGFKIREGMAVGAKVTLRNKRMYNFLEKLIVISLPRVKDFRGISRNGFDGRGNYTFGINEQLIFPEVVYDDIMVSHGMNITMVTSTDNDKEAFKLLELLGLPFAKVR
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: TYSY_EDWI9
Sequence: MKQYLDLMRKVLAEGTPKADRTGTGTLSIFGHQMRFNLQQGFPLVTTKKCHLRSIIHELLWFLNGETNVSYLHENNVTIWDEWADDNGDLGPVYGKQWRAWGCADGRQVDQISQVMEQLRQEPDSRRIIVSAWNVGELDQMALAPCHAFFQFYVADGRLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQLDLQVGDFVWTGGDTHLYSNHMEQTALQLTREPRALPRLVLARRPASIFDYRFEDFIIEGYDPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCDAD_PANTR
Sequence: MLSSWQGGPRPRQLLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKTHGDLLEVNLQNGILFVNSRIDREELCGRSAECSVHLEVIVDRPLQVFHVEVKVRDINDNPPIFPESKKRIIVAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLSLVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVSPAVVYAFTINPNNGEIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSVGAGHVVVKVRAVDADSGYNAWLSYELQLAAVGARIPFCVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVESGQAPQASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPPTEGVCAPGKPTLVCSSAAGSWSYSQQRRPRVCSGEGPHKTDLMAFSPSLPPCLGSAEGTGQREEDSEGLKEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin alpha-13, PCDH-alpha-13.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.