PharMolix/UniProtQA huggingface dataset:
Protein: PFF1_ASPOR
Sequence: MASLRLPRANPLAFTRWPVTVITAIVYLALLIPLLVVHHVVPSAPSSPPSGLNISEAWADLQVLTNGFHPYNSRRNDVIHSWLLRRINEILDSTPLEQEYRALDEEKPDVFVFDDVYSNLTTYGGTLKDADLGVYFEGTNVIVYIRGWEDDTEHWWEAPNGVPTSRGGVLVNSHYDSVSTGFGATDDGVGVVTCLQLVKYFTTPGHAPRRGLVVLFNNGEEDFLNGARVYSQHPISKLPHTFLNLEGAGAGGRATLFRSSDFEVTGPYMRSPHPFGSVLSANGFDTGLIASQTDYVIFQGNMGLRGLDVAFMEPRARYHTNQDDTRHTSKDSVWHMLSAAVATTEGLVSDSTDRFDGAPNTDGGVPSGSGSQAVWFDLFGSTFVLFQLHTLFALLVTLLIVGPLTLLFTSIALTKADKMYLFRSSAKSEDRLDVVPLQGLRGFFRFPFLFGIPTVVTVGLAYLVTKVNPYIIHSSAYAVWSMMVAAWVFLAWFVSRVADFARPSAFHRIYTLTWMYVLSWVSAVIATVYANQRGLAGGYFIFFFHAGIFLAKWISYLELFALPSKTEYANQLRSASGRASGHGSRRGTTSGEDDGEEAEEEPTESTSLLGSGQRTTFANYVRVGGDNHAVAEEEVIDPNVYGREQAWSYALPKWTWVLQLLLTAPITLIMVGPLALLTISAISQTGQDGGHPLFAYVAIAIFTTIMLTPLLPFIHRYTYHVPLFLLAVFLGTLIYNLVAFPFSDSNRLKLYYVQEVDLDTGVNSATFAGLSPFVKDVSQELPSAAGQTVSCEWHTKRRNLLSCSWEGIAPQPVEGDHPMKDWVSFNISKSTDKPQARFEVSGLNTRACRILFDTPVKNFHVAGSAYDPRFPYDAAGVNEIRLWSRTWENQWTVDVDWDEGALKGNVVCLWSDHNQPGVLPALDEAIQFLPVWAAVTKGSDGLVEGRRAFEIGNDD
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: RUVC_PSEA7
Sequence: MTLILGIDPGSRITGFGVVRETARGCEYVASGCIRTGNGPLHERLQVVFRSVREVIRTHGPTTLSIEQVFMARNADSALKLGQARGAAIVAAMEEGLSVAEYTASQVKQAVVGTGGADKQQVQMMVMHLLKLTQKPQIDASDALAIALCHAHTQQSLVPHGLVGARRRGGRLRL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: UBXN3_CAEEL
Sequence: MDLTASLEDDQREKLRQYTEFTHQQDYEVAIGTLASLNWNLEQAIEAHLMQEDKNDDEDPEILETIPAAASGRNAGASSSSRFEPEVINIEDDEMPATRGRRRGRAVTPDETTTVDNQVKRLRIDDGSSSSSNGAATHHRGAAIPRQKRGQATEPTPSSSGSSSASFSSRRGTRANPVPPPNQEPAHPESARQNGGILASRHNNHNNQQNNHHHHHQRIPINPRRVDVFNVDSDEDDDSMAIAYEDDDDGVHEVHHSEVVARGSGPPNGRIPMIPDGFSSVSDALRNFVAIFSDRFCSTPQTQAFMPPFYTEPLPAAVKEAFDHPNSEHRRPLLFYINHDRSIAANIFASQVLCSETVSTLIRHQYVLFPWDITSDSNLMLFLEYLQAANMGDVRTIIQRLAMSKIESFPLMAIVVKERNSYRLVDYCRGTDTSDQVMEKLLSGVSEYSDIRMNEQSERREREEREAIRNQQEAEYKASLAADKARMEAKQQEIEEQRLEEERKLREEEEECVRRQTVASTVPEEPPASAPLAEIINVKFRLPEGGQDMRRFRRLESIQTLINYLSSKGYSPDKFKYFNSDFPKKEITRHFDLSHNFADTKWPAREQIFVEEI
What is the function of this protein?
Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48. 1 and/or cdc-48. 2, conferring substrate specificity (PubMed:20977550, PubMed:26842564, PubMed:28368371).  Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1 (PubMed:20977550).  During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5 (PubMed:26842564, PubMed:28368371).
What are the official names of this protein?
UBX domain-containing protein 3.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Chromosome. Cytoplasm. Note=Colocalizes with cdc-48.1 to the perinuclear region in spermatocytes (PubMed:20977550). Localizes to the nucleus during S phase in a cdc-48 and npl-4-dependent manner (PubMed:26842564).
Protein: MATRX_RINDK
Sequence: MAEIYDFDKSAWDVKGSIQPIGPKTYSDGRLIPQVRVIDPGLGVRKDECFSYIFLWGLSEDSDPLSPPIGRTFGSLPLGVGRSTARPEELLKEATILDILVRRTAGFNEQLVFYDNSPLKVLTPWKKVLTSGSVFNANQVCETVNLIPLDFYQRFRVVYMSITRLSDNGGYDIPRHWPEFRSMNAIAFNSLVTIRFEQSPIEHWRILNSEHLLVATFMVHIGNFQRKKTDMYSADYCKPKIEKMGLVFALGGIGGTSLHIRATGKMSKTLWALEGFKKHLCYPLMDINEDLNRELWRSKCKIVRIQAVLQPSVPQDFRVYRDVIIEDDQGLFKIL
What is the function of this protein?
The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus/respirovirus/rubulavirus M protein family.
What are the subcellular locations of this protein?
Virion.
Protein: Y409_COXBN
Sequence: MTIYRFFKRSAFTLAYIYRRFHEEGCAYRATALAYTTLLALVPLTIVAFTLLSFVPAFQGVGVRLQNLIWENFVPTSAGMVAAYLSQLTQNVTGLSIINIFFLGIVALLLMYNINRAFVAIWHTEHHFRLSLHFLIYFMVLLLSPFLLGAVMLLGTFLVQSPLVTDLIGWPYLGKGLLFVLPYVLIFITFTLFNWVLPSAKVKLSHAVIGGLVTTVLFELAKFAFTVYLKFFPTYRVIYGALSVIPIFLVWLYVSWTIILLGAVVSNVIACGIPEKYK
What are the official names of this protein?
UPF0761 membrane protein CBUD_0409.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCR8_MACMU
Sequence: MDYTLDPSMTTMTDYYYPDSLSSPCDGELIQRNDKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRNITDIYLLNLALSDLLFVFSFPFQTYYQLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYAIKVRTIRMGTTTLSLLVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFEMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLNYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSHIFIYLGRQMPRESCEKSSSCQQHSFRSSSIDYIL
What is the function of this protein?
Receptor for the chemokines CCL1/SCYA1/I-309.  May regulate monocyte chemotaxis and thymic cell line apoptosis (By similarity).
What are the official names of this protein?
C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SURE_PSEPG
Sequence: MRILISNDDGVTAPGIAALHAALADYAECAVIAPDQDKSGASSSLTLDRPLHPQTLANGFISLNGTPTDCVHLGLNGLLPQAPDMVVSGINLGANLGDDVLYSGTVAAALEGRFLGGTSLAFSLLSRQPDNLPTAAYIARRLVEAQSRLALPPRTVLNVNIPNLPLEHIRGIQLTRLGHRARAAAPTKVVNPRGKEGYWIAVAGDAEDGGPGTDFHAVMQGYVSITPLQLDRTFNDAFEQLDGWLEGLL
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSMA3_MOUSE
Sequence: MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLTVSSALHSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKWAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL
What is the function of this protein?
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:25180167).  It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function.  May sensitize cells to DNA damage-induced apoptosis.  In skeletal muscle, mediates TNF-stimulated oxidant production (PubMed:25180167).
What are the official names of this protein?
Sphingomyelin phosphodiesterase 4, Neutral sphingomyelinase 3, nSMase-3, nSMase3, Neutral sphingomyelinase III.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Nucleus envelope. Cell membrane, sarcolemma.
Protein: HPRK_BACCR
Sequence: MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSEQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue.  Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: AZOR_STAAT
Sequence: MAKVLYITAHPFNELVSNSMAAGKAFIETYQQQHPDDEVKHIDLFETYIPVIDKDVLTGWGKMSNGETLTDDEQMKVSRLSDILEEFLSADKYVFVTPMWNLSFPPVVKAYIDAISIAGKTFKYSAEGPQGLLTDKKVLHIQSRGGYYTEGPAADFEMGDRYLRTIMTFLGVPSYETIIIEGHNAEPHKTEEIKATSINNAEKLATTF
What is the function of this protein?
Also exhibits azoreductase activity.  Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
What are the official names of this protein?
FMN-dependent NADH:quinone oxidoreductase, Azo-dye reductase, FMN-dependent NADH-azo compound oxidoreductase, FMN-dependent NADH-azoreductase.
What is the protein family that this protein belongs to?
Belongs to the azoreductase type 1 family.
Protein: RHA4A_ARATH
Sequence: MVDPQSPITPHLYPQAIQLKLYQAFIFSIPILFSIILFLLFYLFYLKRRASSLSSPSPMILPVSSSHQTSSHLPSVCLLDVKVELKDKLHVVLFNEELGTRDSLCCVCLGEFELKEELVEMPLCKHIFHLDCIHLWLYSHNTCPLCRSSVSISSTKTSVDDDNDHPDSPQTSPV
What is the function of this protein?
Probable E3 ubiquitin-protein ligase that may possess E3 ubiquitin ligase activity in vitro.
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase RHA4A, RING-H2 finger A4a, RING-H2 zinc finger protein RHA4a, RING-type E3 ubiquitin transferase RHA4A.
Protein: SYP_LACLS
Sequence: MKQSKMLIPTLREMPSDAQVISHALLMRAGYVRQVSAGIYAYLPLANRVLEKLKNIMREEFDEIGAVELLAPSLLTADLWRESGRYETYGEDLYKLKNRDSSDFILGPTHEETMTSLVRDEITSYKKLPLNVYQIATKFRDEKRPRYGLLRGREFLMKDGYSYHADQDSLDETYLDYKKSYEKIFERAGLNFKPIIADAGAMGGKDSQEFIAITDDRINLEKWLVLSKNITSIDEIPESVLSEIQEELGKWLVAGEDTIVYAEGGDYAANIEMATSQFEPNVAYTEELELEKVATPGAKTIDEVSDFLEIDEEQTVKTLVYHADDELIVILLNGNDQLNEVKLTNRLGASFIEAASEAEVEEKFGAHFGSLGPIGLENVRIIADRKVELIKNAVVGANVDGYHYKNANFGRDFEVEEFVDLRTVNEGEISPDGRGTLKFARGIEIGHIFKLGTRYTEAMNANILDANGRSIPMLMGCYGIGVSRLLSAILEQFARIYVEKTPREEFKFSWSINFPKELAPFDIHLVPVNVKDEAAMELTSELEEKLRGKGYQVLVDDRNERAGVKFADSDLIGLPVRVTIGKKAAEGIVEVKIRATGEVVEINKDELVNTIEILSK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_ECO27
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGICYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ARRS_PIG
Sequence: MAANVQASKSTPNHVIFKKTSRDKSVTIYLGKRDYIDHVDQVEPVDGVVLVDPELVKGKRVYVSLTCAFRYGQEDIDVIGLSFRRDLYFSQVQVFPPVGAASQTKLQESLIKKLGGHTYPFLLTFPDYLPCSVMLQPAPQDVGKCCGVDFEVKAFATDSADTGEDKIPKKSSVRLLIRKVQHAPLEMGPQPHAEAAWQFFMSDKPLHLTVSLSKELYYHGEPIPVTVTVTNNTEKTVKKIKALVEQVANVVLYSSDYYIKPVATEETQQKVPPNSTLTTTLTLVPLLANNRERRGIADGKIKHEDTNLASSTIIKEGMDKTIMGILVSYQIKVQLTVSGLLGELTSSEVATEVPFRLMHPQPEDPEAMDSFQDENFVFEEFARQNLKDAGELKEEKTDQEAAAHE
What is the function of this protein?
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO.  May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
What are the official names of this protein?
S-arrestin, 48 kDa protein, Retinal S-antigen, S-AG, Rod photoreceptor arrestin.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
What are the subcellular locations of this protein?
Cell projection, cilium, photoreceptor outer segment. Membrane; Peripheral membrane protein. Note=Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity). Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes.
Protein: HIS6_AROAE
Sequence: MLAKRIIPCLDVNAGRVVKGVNFVELRDAGDPVEIARRYDEQGADEITFLDITASSDARDIILHVVEQVAEQVFIPLTVGGGVRTVEDVRRLLNAGADKVSINTAAVNNPQVVAEAAGKVGSQCIVVAIDAKQTAPGRWQVFTHGGRNNTGLDAVEWAQKVAALGAGEILLTSMDRDGTKIGFDLGLTRAVADAVPIPVIASGGVGTLEHLAEGVSEGRADAVLAASIFHFGQHTVREAKELMRSRGIEVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_YERPP
Sequence: MRTATLYRYSVPMEAGVILRHQRLKSRDGLLVKLQQGELSGWGEIAPLPEFSQETLDQAQVAAECWLQHWVSGVESDDSVLPSVAFGLSCAQAELKQTLPLSADYRKAPLCTGDPDELFAVLQALPGEKVAKVKVGLYEAVRDGMIVNVLLEALPDLTLRLDANRSWSRAKADGFAKYVNPALRSRIAFLEEPCKTRAESREFAQDTGIAIAWDESVREADFQVEAEPGVAAIVIKPTLVGSLARCQQLVQQAHQAGLVAVISSSIESSLGLTQLARLAAWLTPVTVPGLDTLDLMQAQVVRPWPDSPLPLITTEQLGVVWHR
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: TPRXL_HUMAN
Sequence: MQDPRHPQGLPLSPGLPKRQRQDRTIYNWKQQEVLENHFKEEQYPDYDTRQELAEMLNLREYQVQVWFKNRRAKRSRERWFQKQLQQLQKHPQQQHPQQQHPQQQLQQQQPQQQPQQQQPQQQPQQQQPQQQQLHQQPQ
What is the function of this protein?
Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:36074823).  Protein produced from maternal transcripts that binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 (PubMed:36074823).  Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (By similarity).
What are the official names of this protein?
Tetra-peptide repeat homeobox-like protein.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
Protein: ECSIT_DANRE
Sequence: MSASHHLLRLQCVRCVSHFLGTPVRQVILPGRAHLQTPGSQHIYVQLLRPFHRSAVCSTDRQNRTDIEKLVEDETHHKDKTLVTHDDIFDRAAGDSKTKVEFNRVVDVFKSKDIRRRGHVEFIYAALKKMPEFGVECDVTVYNKLLDVFPKEVFVPQNFIQRMFNHYPRQQECGVQVLEQMENYGVMPNIETKVLLVQIFGEKSHPIRKFQRIMYWFPKFKHTNPYPVPHVLPSDPVDLAQFSLTRIAADLDAKITIYQYPSTDITETGEEITRPHIVGIQSPDQRSLLAKHNPCKPVFVEGPYPLWLRQKCVHYYLLRADPIPPEEKVEEEIDPEMICPEQSLFFPQRVELDLKVDMGDDHSFNVDEVEEGAVYAMCMAGQGDQATLSQWISGLQETCPILGQIPTVFRLESGPRELQTSTDDHQRPEQEAETDQIIEDDEEPRHSRGVKQ
What is the function of this protein?
Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
What are the official names of this protein?
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ECSIT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion.
Protein: MP17L_MOUSE
Sequence: MASWWRAFPQAARRYPWPTNVLLYAGLFSAGDALQQRLRGGPADWRQTRRVATLAVTFHGNFNYVWLRLLERALPGRAPRTVLAKVLCDQTVGGPIALSAFYVGMSVLQGKDDIFLDLKQKFWNTYKSGLMYWPFVQLTNFSLVPVHWRTAYTGLCAFLWATFLCFSQQSGDGTLQSIFIFLRRKEASDKSPEK
What is the function of this protein?
Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes.
What are the official names of this protein?
Mpv17-like protein, M-LP.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal membrane protein PXMP2/4 family.
What are the subcellular locations of this protein?
[Isoform 1]: Peroxisome membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
Protein: CNTN6_HUMAN
Sequence: MRLLWKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRWKQNGTDIDFTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSRGIQFLEPSTHFLSIVIVIFHCFAIQPLI
What is the function of this protein?
Contactins mediate cell surface interactions during nervous system development.  Participates in oligodendrocytes generation by acting as a ligand of NOTCH1.  Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus.  Involved in motor coordination (By similarity).
What are the official names of this protein?
Contactin-6, Neural recognition molecule NB-3, hNB-3.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. Contactin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: SOX5_XENLA
Sequence: MLTEPELPPDINRMSSKRPASPYGEADGEVAMATSRQKMEDEGSDGLPAFHLPLHVGFPSKPHSEEFQAVSLLTQESCDRRSPSYQLNSMELDCNKMSAFALHNVATSPMKAEEVGRQSGDSLSNSMLGTPERRKGSLADVVDTLKQRKMEELIKSEPEETPTIEKLLSKDWKDKLLAMGSGNLADVKGTPESLAEKERQLMTMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAAAQQGFLIPPGFSYKPGCSDPYPLQLIPTTMAAAAAATPGLAPLQLQQLYAAQLAAMQVSPGAKLPGVPQNNLSNSISPSSVHTDKSTSSPPPKSKDDVAQPLNLSAKPKGSDSRSSSSPTSPHIQRLSSGSTHKPISSTSASTPIRLNSIDILSSLTSPGYLNDHDAVTKAIHEARQMKEQLRREQQALDGKVVNSLGLNNCRTEKDKSSLDALTQQLTGKPNEDKFSHAMMDFNLSGDSDGSAGISESRIYREARGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRSRRQGQQTQIPISTAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGIKQEELHIKEEIRGDNINGEMYDEYDEEDDPDIDYGSDSENPSATQAN
What is the function of this protein?
Transcription factor involved in chondrocytes differentiation and cartilage formation.  Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis.  Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: sox5 and sox6 cooperatively bind with sox9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate sox9's ability to transactivate.  Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes.
What are the official names of this protein?
Transcription factor Sox-5, xSox-5, SRY (sex determining region Y)-box 5.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL16_CLAM3
Sequence: MLIPRKVKHRKQHHPGRTGHATGGTVVSFGEYGIQALTPAYVTNRQIESARIAMTRHVKRGGNVYINIFPDRPLTKKPAETRMGSGKGSVEWWVANVKPGRVLFELSGVDEATAREALTRAIHKLPLKARIIKREEGDA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: LICC_HAEIN
Sequence: MNAIILAAGLGSRFKDITQSTHKSLLDIHGTPNLERTLTFLRQANIDNIVIVTGYLHEQFEYLKKKYDCTLIYNEKYREYNSIYSFSLAQDFFNDCYVIDADVVLNRNIFLTKPSHSKYFTVIRSKTHNEWLPILNSNGQVIRIDIGSLNQPSLSGISFWTTQDCNIILTLLKEYTSEVRLKNPKLYWDTIPMEYIEKLNIYTEQLNSDDIFEMDNLDDYHHILQKLTPNKEK
What are the official names of this protein?
Protein LicC.
Protein: NEUH_CARCA
Sequence: RSADGFGRMESLLTSLRGSAESPAALGEASAAHPLE
What is the function of this protein?
Neuropeptide H is the precursor molecule for neuropeptides C, D, E, F and I, which arise by incomplete proteolysis of neuropeptide H.
What are the official names of this protein?
Neuropeptide H.