PharMolix/UniProtQA huggingface dataset:
Protein: CYSK_CITLA
Sequence: MADAKSTIAKDVTELIGNTPLVYLNRVVDGCVARVAAKLEMMEPCSSVKDRIGYSMISDAENKGLITPGESVLIEPTSGNTGIGLAFIAAAKGYRLIICMPASMSLERRTILRAFGAELVLTDPARGMKGAVQKAEEIKAKTPNSYILQQFENPANPKIHYETTGPEIWRGSGGKIDALVSGIGTGGTVTGAGKYLKEQNPNIKLYGVEPVESAILSGGKPGPHKIQGIGAGFIPGVLDVNLLDEVIQVSSEESIETAKLLALKEGLLVGISSGAAAAAAIRIAKRPENAGKLIVAVFPSFGERYLSTVLFESVKRETENMVFEP
What is the function of this protein?
Produces L-cysteine from O-acetyl-L-serine and hydrogen sulfide.  Can also use pyrazole and 3,4-dihydroxypyridine instead of the hydrogen sulfide to produce two plant specific non-protein amino acids beta-pyrazolylalanine and L-mimosine.
What are the official names of this protein?
Cysteine synthase, CSase, Beta-PA/CSase, Beta-pyrazolylalanine synthase, L-mimosine synthase, O-acetylserine (thiol)-lyase, OAS-TL, O-acetylserine sulfhydrylase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_YERPY
Sequence: MLDKTRLRIAMQKSGRLSDESQELLSRCGIKINLQQQRLIAFAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGDDPRYFTLRRLDFGGCRLSLAAPLDAEYTGPQCLQDTRIATSYPHILKQYLDKQGVRFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMSVDKQQLIDRLMTRIQGVIQARESKYIMMHAPSERLDEIITLLPGAERPTILPLAGDKSRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAST1_RAT
Sequence: MELHILEHRVRVLSLARPGLWLYTHPLIKLLFLPSRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVMNVSHSGSVVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAREFQIYREVGGEPVPVTGDDSSNGFPQAQHGPSPTVHPIQSPQNRFCVLTLDPETLPAVATTLIDVLFYSHSVPKEAASGGPESTSIPFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAVDVSAYYISTFNFDHALVPEDEISCVIDILQRRQEGLASKDP
What is the function of this protein?
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway.  As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1.  Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
What are the official names of this protein?
Cytosolic arginine sensor for mTORC1 subunit 1, GATS-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the GATS family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: LEUD_VIBC1
Sequence: MSGFKQHTGLVVPLDAANVDTDAIIPKQFLQKVSRLGFGKHLFHDWRFLDDVGEQPNPEFVMNAPRYQGASILLARENFGCGSSREHAPWALADYGIKAMIAPSFADIFYGNSINNQMVPVRLTEQEVDEIFQFVEANEGAEVEVDLEANVVRANGKEYGFEIDSFRRHCLLNGLDNIGLTLQHEDKIAEYEANIPSFLS
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: ARSI_CANLF
Sequence: MHALTGLSLVSLLSFGYLSWDWAKPSLVADGPGEPGLEQPSAPPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQIHTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRVSHILASHSPRRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITSALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKRRTSRALVHITDWYPTLVGLAGGTASAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHARHGSLEAGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLAAFPGSWWNLERMASARQAVWLFNISADPYEREDLAGQRPDVVRALLARLVDYNRTAIPVRYPAENPRAHPDFNGGAWGPWASDEEEEEEEEEAGRARSFSRGRRKKKCKICKLRSFFRKLNTRLMSQRI
What is the function of this protein?
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.
What are the official names of this protein?
Arylsulfatase I, ASI.
What is the protein family that this protein belongs to?
Belongs to the sulfatase family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Note=Localized in the intracellular granular structures.
Protein: NUOB_PSYCK
Sequence: MKYTLTKANPDADVYPAQTSQTVNDPMEDEVNKNVFMGRLEDLVHSTANWGRKHSLWPFNFGTSCCYVEYATTLTAVHDLSRFGAEVIRASPRQADVMIVAGTCFVKMAPVIQRLYEQMLEPKWVISMGACANSGGMYDIYSVVQGVDKIIPVDVYVPGCPPRPEALIQGLMLLQESITKERRPLGIHVNDQGVYQPQMTPERDRKQADRIAVKNLRSPDSI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ARGE_ENT38
Sequence: MKMNLPPFIEIYRALIATPSISATEEALDQSNESLINMLAGWFSDLGFKVEVQPVPGTRHKFNLLASAGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVKTLKKPLYILATADEETSMAGARYFSENTAIRPDCAIIGEPTSLQPIRAHKGHISTAVRVLGQSGHSSDPARGVNAIELMHDAIGRIMVLRDSLKERFHHDSFTVPYPTLNLGSLHGGDASNRICACCELHMDIRPLPGMTLDDLNGLLSEALAPVSERWPGRLTIFDLHPPIPGYECPPDHQLVQVVEKLLGEKTDVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVVHHFCWH
What is the function of this protein?
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids.  Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
What are the official names of this protein?
Acetylornithine deacetylase, AO, Acetylornithinase, N-acetylornithinase, NAO.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. ArgE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1228_VIBVY
Sequence: MADLISYDDAIDAAYDIFLEMAPDNLEPVDVILFTAQFDDRGAAELVDISDDWAGHVGFDVDKESYAEVRIGLVNEENDVLDDVFARMLISRDPDQKFCHILWKRD
What are the official names of this protein?
UPF0263 protein VV1228.
What is the protein family that this protein belongs to?
Belongs to the UPF0263 family.
Protein: DNLI_ASFM2
Sequence: MLSQFPGQCSNNVFCFPPIESETKNGKKASWIICVQVMQHNTILPITDEMFSTDVKDAVAEIFTKFFVEEGAVRISKTTRVTEGKNLGKKNATTVVHQAFKDALSKYNRHARQKRGAHTNRGMIPPMLVKYFNIIPKTFFEEETDPIVHGKRNGVRAVACQQGDGSILLYSRTEKEFLGLDNIKKELKQLYLFIDVRVYLDGELYLHRKPLQWIAGQANAKADSSELHFYVFDCFWSDQLQMPSNKRQQLLTNIFKQKEDLTFIHQVENFSVKNEDEALRLKTQFIKEGYEGAIVRNANGPYEPGYNNYHSPHLAKLKPLLDAEFILVDYTQGKKGKDLGAILWVCELPNKKRFVVTPKHLTYADRYALFQKLTPALFKKHLYGKELTVEYAELSPKTGIPLQARAVGFREPINVLEII
What is the function of this protein?
Very low-fidelity DNA ligase that seals nicks in double-stranded DNA during DNA repair (By similarity).  Together with the viral repair DNA polymerase X, fills the single nucleotide gaps generated by the AP endonuclease (By similarity).  It is not essential for viral replication and recombination (By similarity).  Displays a very low adenylation activity towards DNA with 3'-dideoxy- or 3'-amino-terminated nicks compared to regular nick DNA (By similarity).
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
Virion. Note=Found in association with the viral nucleoid.
Protein: SSN8_USTMA
Sequence: MSANYWASTQCNNWLLDRPQLELARKEDLRYATRLECAALGVFFSNLLSLICKRLNLRQRVTASANVFFRRFFAKNSYSALDPFLVCATCVYVAAKVEESPIHIKSAVAEATRSFTEHGFRGMPTDHSSLAEMEFYLLEEMEFDMVLFHSYRSLIVMFEDYGSGSAVGSGNSIHERSAGAAGSGSGSGGSGMMIGLGIEAAAFGVTKGLASVEEGDAASAIAEEDKVQLNEFNDEVLLMCWFILNDTYKTDIPLMYPPYMVALASIWLGLSLHPPSFDKITASLHTMQTRRDEHHLSIQRILDNPASTPAELASAKREPSPPSQDALTFFASLNVSLPLLAEIVQEMVSAYSVQHQVQRLVSDGPGIVKLLERMRESRRVALIKDRDQTRTHA
What is the function of this protein?
Component of the SRB8-11 complex.  The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription.  The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator.  It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.  The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
What are the official names of this protein?
RNA polymerase II holoenzyme cyclin-like subunit.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PPR63_ARATH
Sequence: MVRLWCGKLRLWKPYLALATQSRNSWFCSGGGAPSHHLHILKKYGSSEITEMINRYKRNVAGHTLTQNSMVGQYKTTVSPSVAQNVTIETFDSLCIQGNWREAVEVLDYLENKGYAMDLIRLLGLAKLCGKPEALEAARVVHECIIALVSPCDVGARNAIIEMYSGCCSVDDALKVFEEMPEWNSGTLCVMMRCFVNNGYGEEAIDLFTRFKEEGNKPNGEIFNQVFSTCTLTGDVKEGSLQFQAMYREYGIVPSMEHYHSVTKMLATSGHLDEALNFVERMPMEPSVDVWETLMNLSRVHGDVELGDRCAELVEKLDATRLDKVSSAGLVATKASDFVKKEPSTRSEPYFYSTFRPVDSSHPQMNIIYETLMSLRSQLKEMGYVPDTRYYRSLIMAMENKEQIFGYREEIAVVESLLKSKPRSAITLLTNIRIVGDCHDMMKLMSVITGRDMIKRDAKIYHLFKNGVCRCNNLW
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At1g29710, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. PCMP-H subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NADD_ENDTX
Sequence: MHKVAIFGGSFDPVHKSHIQIAKLAFKSLDLKKMIFVIAYTPPHKTKQYAYIEDRISMLKLATGNMQKTEISLYEAQKLETVYSYQTLDYFNSLYPEDEIYMVIGSDSLLDLPIWNNIDYMAGRYKFIVAKRHGFDEVNKNVKYLDRCVFIDKETEDISSTEIRRLVKEDYKKAVSMLNKKVYNYIIQNGLYK
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: RL1_ANADF
Sequence: MAHVAKKFKAASAKVDRVKRYKLDEAMSLVKQTATKKFDETVDAAINLGVDPKHADQVVRGAVVLPHGMGKAVKIAVFAKGDKAREAQEAGADIVGAEDLAEKVQGGFMDFDKVLATPDMMGVVGRLGKVLGPRGLMPNPKVGTVSADIARAVKEQKAGKVEFRVEKAGIVHVPFGKASFEPEKLKANFSAIMEIIYKAKPQTAKGVYVKNVTLSTTMGPGIKLDLSELAAAHG
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: SERF1_MOUSE
Sequence: MARGNQREIARQKNMKKTQEISKGKRKEDSLTASQRKQRDSEIMQQKQKIANEKKSMQTTEK
What is the function of this protein?
Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity).  Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (By similarity).
What are the official names of this protein?
Small EDRK-rich factor 1, Protein 4F5, m4F5.
What is the protein family that this protein belongs to?
Belongs to the SERF family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus.
Protein: CHR4_ARATH
Sequence: MKDSGSEMIKRDWVMKQKRRKLPSILDILDQKVDSSMAFDSPEYTSSSKPSKQRLKTDSTPERNSSKRKGNDGNYFECVICDLGGDLLCCDSCPRTYHTACLNPPLKRIPNGKWICPKCSPNSEALKPVNRLDAIAKRARTKTKKRNSKAGPKCERASQIYCSSIISGEQSSEKGKSISAEESKSTGKEVYSSPMDGCSTAELGHASADDRPDSSSHGEDDLGKPVIPTADLPSDAGLTLLSCEDLSESKLSDTEKTHEAPVEKLEHASSEIVENKTVAEMETGKGKRKKRKRELNDGESLERCKTDKKRAKKSLSKVGSSSQTTKSPESSKKKKKKNRVTLKSLSKPQSKTETPEKVKKLPKEERRAVRATNKSSSCLEDTNSLPVGNLQVHRVLGCRIQGLTKTSLCSALSDDLCSDNLQATDQRDSLVQDTNAELVVAEDRIDSSSETGKSSRDSRLRDKDMDDSALGTEGMVEVKEEMLSEDISNATLSRHVDDEDMKVSETHVSVERELLEEAHQETGEKSTVADEEIEEPVAAKTSDLIGETVSYEFLVKWVDKSNIHNTWISEAELKGLAKRKLENYKAKYGTAVINICEDKWKQPQRIVALRVSKEGNQEAYVKWTGLAYDECTWESLEEPILKHSSHLIDLFHQYEQKTLERNSKGNPTRERGEVVTLTEQPQELRGGALFAHQLEALNWLRRCWHKSKNVILADEMGLGKTVSASAFLSSLYFEFGVARPCLVLVPLSTMPNWLSEFSLWAPLLNVVEYHGSAKGRAIIRDYEWHAKNSTGTTKKPTSYKFNVLLTTYEMVLADSSHLRGVPWEVLVVDEGHRLKNSESKLFSLLNTFSFQHRVLLTGTPLQNNIGEMYNLLNFLQPSSFPSLSSFEERFHDLTSAEKVEELKKLVAPHMLRRLKKDAMQNIPPKTERMVPVELTSIQAEYYRAMLTKNYQILRNIGKGVAQQSMLNIVMQLRKVCNHPYLIPGTEPESGSLEFLHDMRIKASAKLTLLHSMLKVLHKEGHRVLIFSQMTKLLDILEDYLNIEFGPKTFERVDGSVAVADRQAAIARFNQDKNRFVFLLSTRACGLGINLATADTVIIYDSDFNPHADIQAMNRAHRIGQSKRLLVYRLVVRASVEERILQLAKKKLMLDQLFVNKSGSQKEFEDILRWGTEELFNDSAGENKKDTAESNGNLDVIMDLESKSRKKGGGLGDVYQDKCTEGNGKIVWDDIAIMKLLDRSNLQSASTDAADTELDNDMLGSVKPVEWNEETAEEQVGAESPALVTDDTGEPSSERKDDDVVNFTEENEWDRLLRMRWEKYQSEEEAALGRGKRLRKAVSYREAYAPHTSGPVNESGGEDEKEPEPELKKEYTPAGRALKEKFTKLRERQKNLIARRNSVEESLPSGNVDQVTEVANQDEESPTSMDLDDSKASQQCDAQKRKASSSDPKPDLLSQHHHGAECLPSLPPNNLPVLGLCAPNFTQSESSRRNYSRPGSRQNRPITGPHFPFNLPQTSNLVEREANDQEPPMGKLKPQNIKEEPFQQPLSNMDGWLPHRQFPPSGDFERPRSSGAAFADFQEKFPLLNLPFDDKLLPRFPFQPRTMGTSHQDIMANLSMRKRFEGTGHSMQDLFGGTPMPFLPNMKIPPMDPPVFNQQEKDLPPLGLDQFPSALSSIPENHRKVLENIMLRTGSGIGHVQKKKTRVDAWSEDELDSLWIGIRRHGYGNWETILRDPRLKFSKFKTPEYLAARWEEEQRKFLDSLSSLPSKSSRTDKSTKSSLFPGLPQGIMNRALHGKYATPPRFQSHLTDIKLGFGDLASPLPLFEPSDHLGFRSEHFPPMANLCTDNLPGEPSAGPSERAGTSTNIPNEKPFPLNSLGMGNLGSLGLDSLSSLNTLRAEEKRDAIKRGKLPLFLDMPLPQMLDSSNNVFLGRSANPSFLHPNRGLNPSNPMGRDIMGISSSENKLPHWLRNVVTVPTVKSPEPPTLPPTVSAIAQSVRVLYGEDSTTIPPFVIPEPPPPAPRDPRHSLRKKRKRKLHSSSQKTTDIGSSSHNAVESSSQGNPQTSATPPLPPPSLAGETSGSSQPKLPPHNLNSTEPLSSEAIIIPPPEEDSVIAAAPSEAPGPSLEGITGTTKSISLESQSSEPETINQDGDLDPETDEKVESERTPLHSDEKQEEQESENALNKQCEPIEAESQNTNAEEEAEAQEEDEESMKMVTGNSLSDD
What is the function of this protein?
Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription.  May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 (By similarity).  Probable chromatin remodeling factor.
What are the official names of this protein?
Protein CHROMATIN REMODELING 4, AtCHR4, Protein PICKLE RELATED 1.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FABH1_VIBVY
Sequence: MYSKILGTGSYLPSQIRTNADLEKMVETSDEWIVARTGIKERRIAAENETVADMGFYAAQNAIEMAGIDKNDIDLIIVATTSGSHTFPSSACQVQAKLGIKGCPAFDLAAACSGFVYALSIADQHIKTGMCKNVLVIGSDTLSKTCDPTDRSTIILFGDGAGAVVVGASEEPGILSTHIYADGEFGDLLSLEVPERGKDADKWLHMAGNEVFKVAVTQLSKLVKDTLEANGMHKSELDWLVPHQANYRIISATAKKLSMSLDQVVITLDRHGNTSAATVPTALDEAVRDGRIQRGQTLLLEAFGGGFTWGSALVRF
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III 1, Beta-ketoacyl-ACP synthase III 1, KAS III 1, 3-oxoacyl-[acyl-carrier-protein] synthase 3 1, 3-oxoacyl-[acyl-carrier-protein] synthase III 1.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUB1B_MOUSE
Sequence: MAEASEAMCLEGAEWELSKENIQPLRHGRVMSTLQGALAKQESAGHTALQQQKRAFESEIRFYSGDDPLDVWDRYINWTEQNYPQGGKESNMSALVERAIEALQGETRYYNDPRFLSLWIKLGHLCNEPLDMYSYLQSQGIGVSLAQFYISWAEEYEARENFKKADIIFQEGIERKAEPLDRLQSQHRQFQSRVSRQAFLALGNEEEEALEPSEPQRSSLAELKSRGKKMARAPISRVGGALKAPGQSRGFLNAVPQPVHGNRRITVFDENADTASRTELSKPVAQPWMAPPVPRAKENELQPGPWSTDRPAGRRPHDNPASVTSIPSVLPSFTPYVEESAQQTVMTPCKIEPSINHVLSTRKPGREEGDPLQRVQSHQQGCEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKERREAELLTSAKKREEMQKQIEEMERRLKAMQAVQQEGAGGQQEEKMPTEDPARLQIASGPQEMSGVPLSCSICPLSSNPREISPAENILQEQPDSKGSSMPFSIFDESLSDKKDKSPATGGPQVLNAQRRPLSVLKTTEVGTTNEDVSPDICDELTELEPLSEDAIITGFRNVTLCPNPEDTCDFARAARLASTPFHEILSSKGIAADPEGLLQEEDLDGKAAEAHHTVHHQALIIKKLSPIIEESREATHSSGFSRSSSSAPSTSSIKGFQLLEKLELTNDGAEDAIQSPWCSQYRLQLLKSLLELSAFAEFSVEDRPMPVLEIGKEIELGPEDYVIKQEHLTCDDYRLFWVAPRSSAELTMIKASSQPIPWDFYINLKLKERLNEDYDQLCSCCQYQDGHVVWYQYINCSTLQNLLQHSEFVTHEIIVLIIYNLLTIVEKLHRAEIVHGDLSPRSLILRNRIHDPYDYVNKDDHAVRIMDFSYSVDLRVQLDAFAYSGFRTAQILEGQKILANCSSPYHVDLLGIADLAHLLLFKEHLHVFWDGLLWKLSQSTSELKDSELWNKFFVRILNASDKSTVSVLGELAAEMGGAFDATFHSHLNRALWKLGKTISPEALLTQQDKQPGGSQSPA
What is the function of this protein?
Essential component of the mitotic checkpoint.  Required for normal mitosis progression and tumor suppression.  The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle.  One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity.  The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE.  Required for kinetochore localization of CENPE.  Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification.  Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest.  Essential for tumor suppression.  May play a role in regulating aging and fertility (By similarity).
What are the official names of this protein?
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, MAD3/BUB1-related protein kinase, BubR1, Mitotic checkpoint kinase MAD3L.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Cytoplasmic in interphase cells (By similarity). Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1 (By similarity).
Protein: MURG_MYCBP
Sequence: MKDTVSQPAGGRGATAPRPADAASPSCGSSPSADSLSVVLAGGGTAGHVEPAMAVADALVALDPRVRITALGTPRGLETRLVPQRGYHLELITAVPMPRKPGGDLARLPSRVWRAVREARDVLDDVDADVVVGFGGYVALPAYLAARGLPLPPRRRRRIPVVIHEANARAGLANRVGAHTADRVLSAVPDSGLRRAEVVGVPVRASIAALDRAVLRAEARAHFGFPDDARVLLVFGGSQGAVSLNRAVSGAAADLAAAGVCVLHAHGPQNVLELRRRAQGDPPYVAVPYLDRMELAYAAADLVICRAGAMTVAEVSAVGLPAIYVPLPIGNGEQRLNALPVVNAGGGMVVADAALTPELVARQVAGLLTDPARLAAMTAAAARVGHRDAAGQVARAALAVATGAGARTTT
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PHYB_EMENI
Sequence: MAFFTVALSLYYLLSRVSTQAPVVQNHSCNTADGGYQCFPNVSHVWGQYSPYFSIEQESAISEDVPHGCEVTFVQVLSRHGARYPTESKSKAYSGLIEAIQKNATSFWGQYAFLESYNYTLGADDLTIFGENQMVDSGAKFYRRYKNLARKNTPFIRASGSDRVVASAEKFINGFRKAQLHDHGSKRATPVVNVIIPEIDGFNNTLDHSTCVSFENDERADEIEANFTAIMGPPIRKRLENDLPGIKLTNENVIYLMDMCSFDTMARTAHGTELSPFCAIFTEKEWLQYDYLQSLSKYYGYGAGSPLGPAQGIGFTNELIARLTQSPVQDNTSTNHTLDSNPATFPLDRKLYADFSHDNSMISIFFAMGLYNGTQPLSMDSVESIQEMDGYAASWTVPFGARAYFELMQCEKKEPLVRVLVNDRVVPLHGCAVDKFGRCTLDDWVEGLNFARSGGNWKTCFTL
What is the function of this protein?
Catalyzes the hydrolysis of inorganic orthophosphate from phytate.
What are the official names of this protein?
3-phytase B, 3 phytase B, Myo-inositol hexakisphosphate phosphohydrolase B, Myo-inositol-hexaphosphate 3-phosphohydrolase B.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family.
Protein: UVRC_SALSV
Sequence: MSEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQHIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVAGLVSEEEYTQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVTERQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFVGQFYLQGSQMRTLPGEILLDFNLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLARTNAATALITKLSQQSTITQRLTALAAVLKLPAIKRMECFDISHTMGEQTVASCVVFDANGPLRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFAELDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSTLETIEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAG_MSVFR
Sequence: MGQTVTTPLSLTLEHWGDVQRIASNQSVDVKKRRWVTFCSAEWPTFDVGWPQDGTFNLDIILQVKSKVFSPGPHGHPDQVPYIVTWEAIAYEPPPWVKPFVSPKLSPSPTAPILPSGPSTQPPPRSALYPALTPSIKPRPSKPQVLSDDGGPLIDLLTEDPPPYGEQGPSSSDGDGDREEATSTSEIPAPSPMVSRLRGKRDPPAADSTTSRAFPLRLGGNGQKNNNPSFSEDPGKLTALIESVLTTHQPTWDDCQQLLGTLLTGEEKQRVLLEARKAVRGNDGRPTQMPNEVNAAFPLERPDWDYTTPE
What is the function of this protein?
Forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex.
What are the official names of this protein?
Gag polyprotein, Core polyprotein.
What are the subcellular locations of this protein?
[Gag polyprotein]: Virion. Host cell membrane; Lipid-anchor. SUBCELLULAR LOCATION: [Matrix protein p15]: Virion. SUBCELLULAR LOCATION: [Capsid protein p30]: Virion.
Protein: Y2865_ACIF5
Sequence: MHIWVDADACPNVIKDILYRASDRLKLPLTLVANQALRVHRSAYIRTVVVPRGFDVADEEIVRHIVAGDLVITADIPLAAAVLEKNSHALSPRGERYSPETIHERLRIRDMMEQLRDSGVRTGGPAALSQADRQAFANALDQLLVRA
What are the official names of this protein?
UPF0178 protein Lferr_2865.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: LEUD_STAA2
Sequence: MAAIKPITTYKGKIVPLFNDNIDTDQIIPKVHLKRISKSGFGPFAFDEWRYLPDGSDNPDFNPNKPQYKGASILITGDNFGCGSSREHAAWALKDYGFHIIIAGSFSDIFYMNCTKNAMLPIVLEKSAREHLAQYEEIEIDLPNQTVSSPDKRFHFEIDETWKNKLVNGLDDIAITLQYESLIEKYEKSL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.