PharMolix/UniProtQA huggingface dataset:
Protein: LEPA_THEMA
Sequence: MVKFKREVNFSGGDRGVYRPDLIRNICIIAHIDHGKTTLVDRILEITNTVDRRKMREQYLDMMDIERERGITIKAQPVKVMYTAEDGNTYEINIIDTPGHVDFSYEVGRSMAACEGAILLVDATQGVEAQTVAHTYLAIEHDLEIIPVINKIDLPNANIEETALEIKDLLGVSENEILLVSAKEGTGVKELLEAIVKRVPPPKGDINGKLKALIFDAKYDNYKGVIVHVRLFDGQVKPGDKIMTFSNKKVYEVQEVGVFLPEMEPVDSLSAGEVGYIIAGIKEVSDARVGDTITSANDPVDEALPGYREIKPMVFAGMFPGLPEYYEELRKALEKLKLNDSALYFEPTMSPAMGFGFRCGFLGPLHMEVVRERIEREFDLAVILTAPNVRYRVKLRNGEEIEITDPSKFPDEGEILEAYEPYVDLSIITPSEYIGAIINLVQNEKRGELRITENAGKNRVILRFDAPLAEIIYDFFDRMKAVSRGYASMDYEFKEYRRSDLVKVTILVNKEPVDALSFIVHRSKAYQMARKIVEKLKDLIPRHQFQIPIQAKAGGRIIARADIKALRKDVLAKCYGGDVTRKMKLLEKQKEGKKKLREIGRVTIPQEAFLALLKIGGEDEK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TTL_RAT
Sequence: MYTFVVRQENSSVYAEVSRLLLATGYWKRLRRDNPRFNLMLGGRNRLPFGRLGHEPGLAQLVNYYRGADKLCRKASLVKLVKTSPELSESCSWFPESYVIHPTNLKTPVAPAQNGIQLPVSNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFEEFNQYLTSALNITLENSILLQIKHIIRSCLMSVEPAISTKHLPYQSFQLLGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDTEQVPQQPAAFMKL
What is the function of this protein?
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
What are the official names of this protein?
Tubulin--tyrosine ligase, TTL.
What is the protein family that this protein belongs to?
Belongs to the tubulin--tyrosine ligase family.
Protein: KU_MYCTU
Sequence: MRAIWTGSIAFGLVNVPVKVYSATADHDIRFHQVHAKDNGRIRYKRVCEACGEVVDYRDLARAYESGDGQMVAITDDDIASLPEERSREIEVLEFVPAADVDPMMFDRSYFLEPDSKSSKSYVLLAKTLAETDRMAIVHFTLRNKTRLAALRVKDFGKREVMMVHTLLWPDEIRDPDFPVLDQKVEIKPAELKMAGQVVDSMADDFNPDRYHDTYQEQLQELIDTKLEGGQAFTAEDQPRLLDEPEDVSDLLAKLEASVKARSKANSNVPTPP
What is the function of this protein?
With LigD forms a non-homologous end joining (NHEJ) repair enzyme.  Binds linear dsDNA with 5'- and 3'-overhangs but not closed circular dsDNA nor ssDNA.  One dimer binds for every 30 bp.  Recruits and stimulates the ligase activity of LigD but not of T4 ligase or a human ligase complex (LIG4/XRCC4).  Attenuates the 3'- to 5'-exonuclease activity of LigD.  Stimulates the template-directed addition of dNTPs by LigD on 5'-overhangs and nuclease activity on 3'-overhangs.
What are the official names of this protein?
Non-homologous end joining protein Ku, Mt-Ku.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic Ku family.
Protein: BIT61_YEAST
Sequence: MTAEDILLRERTSTTTQRPVNSEQYLNVQLATAPVKNFQTTSEISRQTLVDTSNDDVYSIKNLKGSRNPISPSVSNVGFQSIFHTVDHPRSKVSVASNHSLRSNDNASAATSKSGSSQIGESHSVDTVECSNNLSKKLSSDAISITQKSLHSTPSGRYMKGKASGFFNRRNRAHTTISSDPASFLTDSSTLHNSSHSFRNVIKNFFQNKSHRHIGQDAIEPAIPNSLSKFLHSSYGRHKSPSQFIHTNAGQLVDSGTSVYSLNVNPSGVNPNTIVEDPLSGTDPASPNPVSMLHDLLRNLPSLEANYKHFNSQELTTLTNNIWNIFCSNVAELFRTQRIWKLRAKIENFNEVLEFYCILKTDPRVTHSGMNRIISDLKEFLVSSLYNLENQIVFNYSNEDTINNALKRLGVIWRIFYQEVYYDLAAVLLPLDQSIREDGNSTVLKSGNESRTHINGNYSIGFLLLMCFRDSIVLPCYENFVNSNDGISKSFQLYIFNQEEESNVTETDKLTLLQCFGILSTIQSNDRNQRIIEELLAGIRMSI
What is the function of this protein?
Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity.  TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
What are the official names of this protein?
Target of rapamycin complex 2 subunit BIT61, TORC2 subunit BIT61, 61 kDa binding partner of TOR2 protein.
What is the protein family that this protein belongs to?
Belongs to the BIT61 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Vacuole membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RUVC_SHEON
Sequence: MAIILGVDPGSRITGYGVIQCQGRQQLYLGSGCIRTSGDDLPLKLKQIFDGISEIIRQYQPDEFAIERVFLAKNADSALKLGQARGAAIVAATVANLPVAEYSATQIKSAVVGTGRAKKEQVQHMIQQLLKLPAAPQADAADALGVAVCHYHTNQSLVALSGRATTRTYGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: FOLD_BURP6
Sequence: MTATLIDGNALSKTLRAQAAERAAALAARGHRPGLAVILVGDNPASEVYVRNKIKACEDNGFFSLKDRYPATLSEPELLARIDELNRDPKIHGILVQLPLPAHIDSHKVIEAIAPEKDVDGFHVANAGALLTGKPLFRPCTPYGVMKMFEAYKIPLQGANAVVIGRSNIVGKPMALLLLEAGATVTICHSKTRELAAHTRAADIVVAAVGKRNVLTADMVKPGATVIDVGMNRNDEGKLCGDVDFAGVSQVAGHITPVPGGVGPMTITMLLVNTIEAAERAAAAA
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SCG3_DANRE
Sequence: MASKRLGFVVVLALVCQHINAFPTPAGPDDKYNRELTEEKPLEQQIAEADSIRKTESKPTPPAEEETNSEDDDITFLKALAEKSKESNNETPISDSANERLGADDTDSTKNRRLADDYDSTKNGMDYKYQDDPESFRQLDGTPLTAQDIVQKIANKIYEEDDRGVFDRIVSKLLKLGLITDSQAETLEYEVAEALQDLITKNAKDNMIGDRSVDYPVSAAKDTQDEEDRPSPRFDEEDEVENEGGDDANGDEPQEEESRDDTVRSDDSWDAVSDGNDRNELNPEDGLQDLQFFPNFYRLLKSLDSEQDKEERETLITIMKTLIDFVKMMVKYGTITPEEGVTYLENLDAMIALQTKNKLGKSLVPLSITPPTGKAADDDDNTKTEAAKMQKEYESLKDSTKDVQTAAEISHPGKSESYLEAIRKNIEWLKKHNKEGNKEDYDLSKLRDFMDQQVDSYIDKGILEKDEGDVIKRIYGSL
What are the official names of this protein?
Secretogranin-3, Secretogranin III, SgIII.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted. Note=Associated with the secretory granule membrane through direct binding to cholesterol-enriched lipid rafts in intragranular conditions.
Protein: GON2_SPAAU
Sequence: MCVSRLVLLLGLLLCVGAQLSNGQHWSHGWYPGGKRELDSFGTSEISEEIKLCEAGECSYLTPQRRSVLRNILLDALARELQKRK
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-2, Progonadoliberin II.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS13_ALBFT
Sequence: MARIAGINIPPQQHSEIGLTAIFGVGRNRARKICDACGIAYSKKVKDLTDLELEKIRDQVAQFTIEGDLRRETTMNIKRLMDIGCYRGFRHRRGLPMRGQRTRTNARTRKGPRKAAQSLKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SYM_MYCBO
Sequence: MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDGYDVRFLTGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASKELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYFFRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPDHVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVRGHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRIAALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPEGK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_NOCFA
Sequence: MTSVDTPTPHGGTPAPAPATANGRKLLRIEARNAQTPIERKPKWIRTRATMGPEYSELKGLVKREGLHTVCEEAGCPNIFECWEDREATFLIGGEQCTRRCDFCQIDTGKPAALDRDEPRRVAESVQAMGLRYSTITGVARDDLEDGGAWLYAETVRAIKRLNPATGVELLIPDFNADPDQLAEVFSARPEVLAHNLETVPRIFKRIRPAFRYERSLSVLTAAREAGLVTKSNLILGMGETPEEVTEAMRDLHEAGCDILTITQYLRPSPRHHPVDRWVKPEEFVEHSRVAEEIGFAGVMAGPLVRSSYRAGRLYAQAMAHHGREIPPAMAHLAEEGTASQEASAVLARFGS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MGLL_MOUSE
Sequence: MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
What is the function of this protein?
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:9341166, PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566).  Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:9341166, PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566).  Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity).
What are the official names of this protein?
Monoglyceride lipase, MGL, Monoacylglycerol lipase, MAGL.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Protein: LPRF_MYCTU
Sequence: MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVAGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG
What is the function of this protein?
Might be involved in transporting short diacylated glycolipids to the cell outer membrane (By similarity).  Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M. smegatis).
What are the official names of this protein?
Putative diacylated glycolipid transporter LprF, Lipoprotein LprF.
What is the protein family that this protein belongs to?
Belongs to the LppX/LprAFG lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Extracellular side.
Protein: KV17_RABIT
Sequence: ADIVMTQTPASVSEPVGGTVTIKCQASQSIFBBLAWYQKPGZPPKGLLYTBYTLASGVSSRFSGGGSGTBFTLTISDLECABAATYYCEXTGVSZBXBKGFGGG
What are the official names of this protein?
Ig kappa chain V region XP-1.
Protein: TRBM_HUMAN
Sequence: MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
What is the function of this protein?
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin.  This complex is responsible for the conversion of protein C to the activated protein C (protein Ca).  Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
What are the official names of this protein?
Thrombomodulin, TM, Fetomodulin.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RSMH_CLOD6
Sequence: MEFHHVSVLLNECIENLNIKPDGVYVDCTMGGAGHSKEIVKKLSDKGLFIGFDQDKNAISTAKERLSEYESRVKFVHSNFENIKEELEKIGVYKIDGVLADLGVSSHQLDEADRGFSYMQDAPLDMRMDVRCEFSAYDVVNTYTEDELTKIIKDYGEDNWAKRIAKFIVEERANKPIETTGELVDVIKKAIPKKARIVGPHPAKRTFQAIRIEVNNELGVITKMINDASSIMNEGGRICIITFHSLEDRIVKNAFKHLASDCICPQHLPICQCDKESEVKIITRKPILPSEEEIEVNPRSRSAKLRVAEKI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDGR3_HUMAN
Sequence: MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADASSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSSEGGDAGNDTRNTTSDLQKTSEGT
What is the function of this protein?
Enhances DNA synthesis and may play a role in cell proliferation.
What are the official names of this protein?
Hepatoma-derived growth factor-related protein 3, HRP-3, Hepatoma-derived growth factor 2, HDGF-2.
What is the protein family that this protein belongs to?
Belongs to the HDGF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y675_SYNP6
Sequence: MATASSFDVVSDFDQQELVNAVDQARREITNRYDLKDSATTLELTAETLTINTDSEFSLDAVVTLLQTKVAKRNLSLKIFDFGKVETASGNRVRQVITLQRGLSSELAKDLSKQIRDQFKKVQVSIQGDALRVSAKSKDDLQTVIQYLKQQDVPAPLQFTNYR
What are the official names of this protein?
UPF0234 protein syc0675_c.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: AP4A_MYCTU
Sequence: MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP
What is the function of this protein?
Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP.  It does not catalyze the reverse phosphorolysis reaction.  The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.
What are the official names of this protein?
AP-4-A phosphorylase, ATP adenylyltransferase, Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase, AP,A phosphorylase.
Protein: DEOC_STRS7
Sequence: MNINKYIDHTLLKADSVQSQLDQLIEEAKAYDFASVCVNPCWVAYAAKALKGTDVKVCTVVGFPLGATTSATKAFETKDAIENGADEIDMVINIGLLKQGDYQAVEDDMRAVVEASGDKLVKVIIEACLLTDDEKVKACQLAVNAGVDFVKTSTGFSTGGATVSDVKLMRQTVGPDIGVKAAGGARSLEDALAFVEAGATRIGTSAGVTIMKGEVANGGY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED11_KLULA
Sequence: MSQPEYIRERLDSLAKIDKQLVDVLHRASLTVSSLIDLKKRNEESKPQFQQNAQEFYDDLESATVQLRKEIKLLDENVGTRLLPIQTHKKATGQDNVKLEEQFKLLTKYLGKDQQS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 11, Mediator complex subunit 11.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 11 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GALR1_RAT
Sequence: MELAPVNLSEGNGSDPEPPAEPRPLFGIGVENFITLVVFGLIFAMGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGFIWALSIAMASPVAYYQRLFHRDSNQTFCWEHWPNQLHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLWAEFGAFPLTPASFFFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCRVCNESPHGDAKEKNRIDTPPSTNCTHV
What is the function of this protein?
Receptor for the hormone galanin.  The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
What are the official names of this protein?
Galanin receptor type 1, GAL1-R, GALR-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLYA_RICAH
Sequence: MNIFNNNLHETDKEINEIIKHEKLRQSSVIELIASENFVSPAVLEAQGSILTNKYAEGYSGKRFYNGCEEVDKAENLAIERVKKLFNCKYANVQPHSGSQANQAVYLTLLQPGDTILGMSLDSGGHLTHGASPNMSGKWFNAVSYGVNKKTYLIDYDEIERLAVLHKPKLLIAGFSAYPRNIDFTRFREIADKVGAYFMADIAHIAGLVATGEHQSPISYAHVVTSTTHKTLRGPRGGLVLSDDEEIGKKINSALFPGLQGGPLMHIVAAKAVAFLESLQPEYKSYIKQIISNAKALASSLQERGYDILTGGTDNHIVLVDLRKNGITGKLAANSLDNAGITCNKNAIPFDETSPFITSGIRLGTPACTTRGFKEQDFVSVGHMVADILDGLKNNKDNTKAEQQVLHKVTKLIKLFPFYD
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y0436_DICDI
Sequence: MNSFEKKILILKKDDKDSFIALVKQLSTKEKQILFDTIDSRIRKLQTIYLNKPFNLKFLQTFIKEDSDEDDDDEEDEEDEEDSDEEEDDDVVEDDNTKDIGKSRDSDKSIKGKEKGKEKEKEEIEIIEQRYETKVIPKKPIYKDQQQELLQQLQLQQLQQKPISPIKDNSGVSYNTSFSSLSSLSMSNSTSSSLLSTSLLSASLLSASSSGLSTSSLSSSINNSSNNNSNISSSPLSSSPLTLSSSSSSSSPLQRIQSIQNLIRSNSLRTSLSSSSSLLPNLIQLQQQQLPPPPPSQQQQQQQQQQQQQNNSMLQQSNNNNISPRTQLLNNTTTLLPNNGLEEIFNDSNKIGEGGQCSIYKYMGTAMKRFKPSLSSSLISKEFENEVLILERLNHPNIVKIITYSTIERIILLEFIDGNSLDKYPSQSLPLSPSSSLPNPLKVIQDFQQIVDAMIYLHNEIGIIHFDLKPSNILKNSKNNKLKLIDFGISKFLNNNNQNNNNNSLNMGSYRYSPPELLCNNNQNNNLINKSVDVFSFGIMLWECLNWTLPYESLSREQVKQIKTDMERESHLPLDHLPKGIQDLIRLCWKHDPSIRPSFIEIRSRLSEIILNNIPSLNGRQFWISSSKYLQQNDDSLINNNNNNNQNNNNQNNNNNNNNNNNNNNNNKDETTSIIIYESIPWLKFKTFLSNHLNIYRQSSTSNSNSSFNLNNNSSRNNQRQQQQQNNRNRSVYNNNYNNNNNNIINNNNNNINNNRNRNYNAYYEYIFDYIRYILKVIDEKRDEVSVIEFSRFCTFFSPLISSSLFRSIQIFCDIPGLYGYCLKKDLILSSSMITLMSKIGYLIFIDPNNINQLFLKMKAPTSSSSNKNNNNNNNDNNNPSNFIDFTIRVKIGNYNQRIFQCHGHTSSSLSGLIKELQPLIDNNNSGNSSGSSSSKKSNSGFLYQKTPISEIKDRHINGSYLNQNYK
What are the official names of this protein?
Probable serine/threonine-protein kinase DDB_G0290621.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Protein: RDL1_YEAST
Sequence: MWKAVMNAWNGTESQSKNVSNIQSYSFEDMKRIVGKHDPNVVLVDVREPSEYSIVHIPASINVPYRSHPDAFALDPLEFEKQIGIPKPDSAKELIFYCASGKRGGEAQKVASSHGYSNTSLYPGSMNDWVSHGGDKLDL
What is the function of this protein?
Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631).  Provides the link between the first step in H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631).  The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).
What are the official names of this protein?
Thiosulfate:glutathione sulfurtransferase, TST, Rhodanese-like protein 1.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SEPF_BREBN
Sequence: MGVMNKLMGFLGLENEEYIEETTTVEEEREEQESSHKRQPAISRTNNVVPFQAREKEGIRLILCEPRHYSDAQDIADNLRHRRPVVVNLHRVEKDQAKRIIDFLSGTVYALNGDIQKVGDTIFVCTPDHVDIQGTISSVLEE
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: SIX2_ISOVI
Sequence: KKNGYAVDSSGKAPECLLSNYCNNECTKVHYADKGYCCLLSCYCFGLSDDKKVLDISDTRKKYCDYTIIN
What is the function of this protein?
Excitatory insect beta-toxins induce a spastic paralysis.  They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity).
What are the official names of this protein?
Toxin Isom2, IsomTx2.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.