PharMolix/UniProtQA huggingface dataset:
Protein: AMT7_ALTAL
Sequence: MFEPYLTTPLLLKAANTPHHIPKMSRICSDRPSTLVKYGNRVQPFPFPERQWPNKVLKTAPVLFSTDLRDGNQSLPNPMTFEQKLSLYKLLVSIGFKEIEVAYPCANQAEFDFVRHLIETPGLIPEDVLIQVITPCQEETIKRAVESVRGAKQAILFTYLPSSDNYRDTVLKISEDDWVERARWGAAYARSITKDSEDPVVRSTRWTFNFGFEDFANARIGAIIRCTEAVRAEWNPSKDEKMIIGVASSVEASTPNVFADQIECLSGNISNRDTVRLTVHTHNDRGGAVASAELASLAGADRIEGCLFGNGERAGNMDLVVYALNLLTQGIEPGIDLSRLDEIRKVYEDITELPVHPRTPYSGAYYLKAFSGAHQDAISKGLRLRTSATQEGKPCAVWPAWRVPYLPLDPADIGRSLDDVVGINSQSGKGGVAWVVNLGLGLDLPPGLARTFSKAVKERSIHFGREMSSDEVCMAFLEEYQVLRAADKSDDDMIQAVLRTESPLVAALGQVVGLSSLSASITSHTLADDVLSYAAYANVTPEESKPSLWGVGLGVSLQQAKLRAVVSALQVSDGSMSWVRLA
What is the function of this protein?
Isopropyl malate synthase; part of the gene clusters that mediate the biosynthesis of AM-toxins, host-selective toxins (HSTs) causing Alternaria blotch on apple, a worldwide distributed disease (Probable).  AM-toxins are cyclic depsipeptides containing the 3 residues 2-hydroxy-isovaleric acid (2-HIV), dehydroalanine, L-alanine which are common for all 3 AM-toxins I to III.  The fourth precursor is L-alpha-amino-methoxyphenyl-valeric acid (L-Amv) for AM-toxin I, L-alpha-amino-phenyl-valeric acid (L-Apv) for AM-toxin II, and L-alpha-amino-hydroxyphenyl-valeric acid (L-Ahv) for AM-toxin III (Probable).  AM-toxins have two target sites for affecting susceptible apple cells; they cause invagination of the plasma membrane and electrolyte loss and chloroplast disorganization (PubMed:22846083).  The non-ribosomal peptide synthetase AMT1 contains 4 catalytic modules and is responsible for activation of each residue in AM-toxin (PubMed:10875335).  The aldo-keto reductase AMT2 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV), one of the precursor residues incorporated by AMT1 during AM-toxin biosynthesis, by reduction of its ketone to an alcohol (PubMed:15066029).  The cytochrome P450 monooxygenase AMT3 and the thioesterase AMT4 are also important for AM-toxin production, but their exact function within the AM-toxin biosynthesis are not known yet (PubMed:17990954).  Up to 21 proteins (including AMT1 to AMT4) are predicted to be involved in AM-toxin biosynthesis since their expression ishighly up-regulated in AM-toxin-producing cultures (PubMed:17990954).
What are the official names of this protein?
Isopropyl malate synthase AMT7, AM-toxin biosynthesis protein 7.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: LYSZ_PYRAB
Sequence: MRVIKVGGSVVPMLDKILDTSSLHGNSIIVHGGSRYVDEMARKLGVKVERLVSPSGVMFRRTTRRVLDVYVAALMRANRELVSFLRERGIDAIGVSGLDGVVLAKRKKLVKAVVNGKVIAIRDDYSGVIKSINVTLLKNYLKVGIPVIASIAYDPEENVPLNVDGDKVAYHVAIAMKAKELRFLSDTAFLIDGNVVERIPLEDFDEYLRYAGGGMKKKLMMARKALESGVKKVVIEGLNGRTVIS
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.  Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
What are the official names of this protein?
Putative [LysW]-aminoadipate/[LysW]-glutamate kinase.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. LysZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_KOSOT
Sequence: MIKGVEGEITEISGNEVTLKAGQFYLNILCSTNTIKELSLSAKVHLLTYLSFSADRAPEIYGFKDRAEYNVFLMLLKANKIGPKMALKILSATSPEMLQKMIASKDISGLSRLPGLGKKTAERLVSELYDLVKDYAVEFPKELSDVSEDAVGALTALGFDMTSAKLAVNEVLKEQTVENTQELVRKALRKLNKTR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PD5BA_XENLA
Sequence: MAHSKAKGNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKEQYLNLALHLASDFFLKHPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFISRQLKGLEDTKSPQFNRYFYLLENIAWVKSYNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIVCEGDTVSQELLDSVLVNLVPAHKNLNKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFKLKSNDNEERLQVVKLLAKMFGAKDSELASQNKTLWQCYLGRFNDIHVPVRLECVKFASHSLVNHPDLAKDLTDYLKVRSHDPEEAIRHDVIVSIVTAAKKDLLLVNDQLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYSLQAEAGKESAKQISWIKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDTNAVKALNEMWKCQNMLRHHVKDLLDLIKKPKTEAGSKAIFSKVMVITRNLPDPGKGQDFLKKFTQVLEDDEKIRGQLEKLVSPTCSCKQAEVCVRDITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKLVNKSIDGTADDEDEGVTTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGSKIEEDFPHIRSALLPVLQQKAKKGPPRQAKYSIHCIQAIFSSKETQFAQIFEPLHKSLDPGNPEQLITSLVSIGHIAQLAPDQFTAPLKSMVATFVVKDLLMTDRLPGKKTTKLWVSDDEVSTETKVKIQAIKMMVRWLLGMKNNLSKSGNSTLRLLMAILHTDGDLTEHGKLSKPDMSRLRLAAASAIVKLAQEPCYHEIITLEQYQLCALVINDECYQVRQLFAQKIHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNINVRREYLKQHAAVSEKLFSLLPEYVVPYTVHLLAHDPDYVKVQDIEQLKDIKECLWFVLEILMSKNENNSHAFIRKMVEYIKQTKDGQNPDDQKMNEKMYTVCDVAMNIIISKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPAELKSFFTPGKPKSTNVLGAVNKPLSSAGKQMLSKSSRMETVSNASSGSNPSSPGKIKGRLDSMELDQSENEDYTMSSPLSGKKSDKRDDSDLLKSELEKPRRGKKQSLIDQDDSLSMDELSKPAQEPKSRTGQRGRKRAAAASDSEEQTWQEKRLKEDLLENEDEQNSPPKKGRRGRPPKSAKMAISKEEPTVTTPKRGRKKAVPVESPPTDEDDHLEISEEQDFENIDQKRKGRGSSRRTPQKSDSTDSLLDTSRPTPQKRRGRPPKTPTVQQKKSHVGRPRKVVSKEPESEEEMEMSQNSPALSEHLSNEDESAEEVVVAPSTGRLRSAKKR
What is the function of this protein?
Plays a role in androgen-induced proliferative arrest (By similarity).  Required for maintenance of sister chromatid cohesion during mitosis.
What are the official names of this protein?
Sister chromatid cohesion protein PDS5 homolog B-A, Androgen-induced proliferation inhibitor A.
What is the protein family that this protein belongs to?
Belongs to the PDS5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS7_PYRFU
Sequence: MAKPLNERFFIPHEIKVMGRWSTEDVEVRDPSLKPYINLEPRLLPHTHGRHAKKHFGKANVHIVERLINKIMRSGGSHYKVAGHFMRREHRSLNSKKVKAYEVVKEAFKIIEQRTGKNPIQVLVWAIENAAPREDTTSVMFGGIRYHVAVDISPMRRLDVALRNIALGASAKCYRNKMSFAEALAEEIILAANKDPKSYAYSKKLEIERIAESSR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center.
What are the official names of this protein?
30S ribosomal protein S7, Small ribosomal subunit protein uS7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: TAGF_STAEQ
Sequence: MNKLTIIVTYYNAEEYITGCLESIKQQRTQDFNLIIVNDGSTDQSKKLMDEAIKDYDKNIRFIDLDENSGHAHARNIALEEVETPYFMFLDADDELASYAITFYLEKFNNTDGLIAPIHSFTTQRPQFVDLDRVRVEYFNAKENINSFLRKQSACNIIFRTAIVRAHHIRFNENLNTYVDWSFVLEYMKYVNKFVRIFNFPFYFRGEVYDPFETLTLSEQNFDILFKDYVNSFYDAIKRATNPKVREFIVTKMGNKIANEFEPTRYDINERYQTHKDTLVELSKFLHVHLVKNQKLINKIETILLMNNETDKAFKVNQFRKTLRHVKNIVLRRKNKERSLYDLTDKEDNVKPKTIVFESFGGKNYSDSPKYIYEYMQKYYPNYRYIWSFKNPDKNVVPGSAEKVKRNSAEYYQAYSEASHWVSNARTPLYLNKKENQTYIQTWHGTPLKRLANDMKVVRMPGTTTPKYKRNFNRETSRWDYLISPNRYSTEIFRSAFWMDEERILEIGYPRNDVLVNRANDQEYLDEIRTHLNLPSDKKVIMYAPTWRDDEFVSKGKYLFELKIDLDNLYKELGDDYVILLRMHYLISNALDLSGYENFAIDVSNYNDVSELFLISDCLITDYSSVMFDYGILKRPQFFFAYDIDKYDKGLRGFYMNYMEDLPGPIYTEPYGLAKELKNLDKVQQQYQEKIDAFYDRFCSVDNGKASQYIGDLIHKDIKEQ
What is the function of this protein?
Responsible for the polymerization of the main chain of the major teichoic acid by sequential transfer of glycerol phosphate units from CDP-glycerol to the disaccharide linkage unit.  Synthesizes polymers of approximately 35 glycerol phosphate units in length.
What are the official names of this protein?
Teichoic acid poly(glycerol phosphate) polymerase, CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase, CGPTase, Major teichoic acid biosynthesis protein F, Poly(glycerol phosphate) polymerase, Tag polymerase.
What is the protein family that this protein belongs to?
Belongs to the CDP-glycerol glycerophosphotransferase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MGSA_SYMTH
Sequence: MRIALIAHDNRKQDMLKFVKDHKSAFEGHQLFATGTTGKLIREHTGLDVHCFLSGPLGGDQQIGSRVATGEIDMVIFLRDPLTAMPHEPDVQGLLRLCDVRDIPVATNLGSARMFADDLMRLKDVK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: PRMC_DICTD
Sequence: MAQPLREVLVWLNNKIKEINPESAWLEAELLVAFVLNKDRAFIYTIDFLTDEEVEKLKKLLDLRKKGIPLNYIIEKKQFYDIELFVERGVLIPRSETEILIEVAKDTILKEGYKKIVEIGVGSGNISITLAKEFKDIKIYACDISPEAIKVARFNAKKHKVSDKIEFFFGFLLYPMVHRNVDFELIISNPPYIASWEFPFLQKEVKKEPWKALYGGWDGCEFYRKLFTLLKKRGKNFTAILEISPYIYHKVLNILKNFFDSVIIESFRDYLGHERVIKVIWH
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: DHA_BILW3
Sequence: MRVGIPTEIKVQEFRVGITPAGVHALKEAGHTVLVQKGAGLGSMITDEEYVAAGAQMVATAKECWDCDMVVKVKEPLAPEYDLFHEGLILYTYLHLAPEPALTKALLEKKVIGIAYETVQFDNGFLPLLAPMSEVAGRMATQVGAQMLTKIEGGMGLLMGGTAGVQAAHVVILGAGTVGLSAAKVAMGMGARVTILDSNLFRLRQIDDLFGGRIQTLASNAFNIAAATKDADLLVGSVLIPGALTPKLVTEAMVKTMKPGSAIVDVAIDQGGCIEPTAKHGATYHDKPTFKYPVNGGEVVCYSVGNMPGAVARTSTFTLTNATMPYMVDLANKGWKKACQDDKALARGINTYDGKVYFKGVSDALGYELHCTCDILK
What is the function of this protein?
Involved in an anaerobic respiration pathway that converts the sulfonate taurine (2-aminoethanesulfonate) to ammonia, acetate and sulfide.  Acts as an alanine dehydrogenase that regenerates pyruvate, the amino group acceptor for the taurine--pyruvate aminotransferase enzyme, and liberates ammonia.
What are the official names of this protein?
Alanine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the AlaDH/PNT family.
Protein: ARCA_LIMF3
Sequence: MTSPIHVTSEIGKLKTVMLHRPGREIENITPDYMERLLFDDIPYLPIAQEEHDFFAQTLRDQGIEVLYFEKLAAEALASDDVRKEFLNRMIAESGYVAGTTHDALYDYLYQMTPQEMVDKIIEGVRGTDIDIAQPDLQSVSENTDWPFLMDPMPNAYFTRDPQASIGDGISINKMTFPARQRESLITEYIINHHPRFAGQVEVWRDRNHESHIEGGDELVLSDHVLAIGVSQRTTADAIEDIARNLFKDSNYDTVIAISIPHNHAMMHLDTVFTMINHDQFTVHPAILDDKGEVDNWVLHPGKDGEITIEHHTDIKAVLKQALNKPEIDLIPTGNGDPIVAPREQWNDGSNTLAIAPGEVVTYNRNYVSNALLKEHGILVHEVRSSELSRGRGGPRCMSCPIVREDL
What are the official names of this protein?
Arginine deiminase, ADI, Arginine dihydrolase, AD.
What is the protein family that this protein belongs to?
Belongs to the arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPH_BACC7
Sequence: MKMMDANEIISFIQKSEKKTPVKVYIKGNLKEVTFPETVQAFVNKKSGVLFGEWSEIKTILDENSKYIVDYVVENDRRNSAIPMLDLKGIKARIEPGAIIRDHVEIGDNAVIMMNATINIGAVIGEGSMIDMNAVLGGRATVGKNCHVGAGAVLAGVIEPPSAKPVIVEDDVVIGANVVVLEGVTVGKGAVVAAGAVVTEDVPPYTVVAGTPARVIKEIDEKTKAKTEIKQELRQLNPEK
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: TUSA_IDILO
Sequence: MTQINCDKELDTLGLKCPEPVMLVRAAIRKMDVGQVLLIIADDPATTRDIPGFCEFMEHELVGSETEEIPYRYWVRKSH
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_BACAC
Sequence: MFQVQKELASHEAVVVALFEEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTDVKRYYFVGLGKKESYTTETLRSALGKTFKTLQAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYELQTYKSDKKDRVELEKFTAITAEDAQEIEAALTVGYVHGRATNSARTLVNMPPNVLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSVEPPKMIALIYKGKEEWTDVIGFVGKGITYDTGGYSLKPREGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLIDVATLTGGVIVALGNHTTGAMTNNEELFEQVLEASMETDESIWQLPIFDRDKERVRNSKFADLNNSPGREGHAVMAGTFIGEFAEDTPWVHLDIAGTSESSGAHDLGPAGATGAMVRTLATLVERFGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_MYCTA
Sequence: MNRKNVTRTITAIAVVVLLGWSFFYFSDDTRGYKPVDTSVAITQINGDNVKSAQIDDREQQLRLILKKGNNETDGSEKVITKYPTGYAVDLFNALSAKNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPMAADADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITGPALEEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTTGAVSDIEQATKIARSMVTEFGMSSKLGAVKYGSEHGDPFLGRTMGTQPDYSHEVAREIDEEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPELESIFADVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPVPEPAFKAAIAQATQAAEAARSDAGQTGHGANGSPAGTHRSGDRQYGSTQPDYGAPAGWHAPGWPPRSSHRPSYSGEPAPTYPGQPYPTGQADPGSDESSAEQDDEVSRTKPAHG
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: RS11_LISIN
Sequence: MARKTNTRKRRVKKNIESGIAHIRSTFNNTIVMITDTHGNALAWSSAGSLGFKGSRKSTPFAAQMAAESAAKSAQEHGLKTLEVTVKGPGSGREAAIRALQAAGLEVTAIKDVTPVPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: JAM3_RAT
Sequence: MALSRRLRLRLCARLPDFFLLLLFRGCVIEAVNLKSSNRNPVVHEFESVELSCIITDSQTNDPRIEWKKIQDGQTTYVYFDNKIQGDLAGRTDVFGKTSLRIWNVTRSDSAIYRCEVVALNDRKEVDELTIELIVQVKPVAPVCRVPKAVPVGKAATLQCQESEGYPRPYYSWYRNDVPLPTDSRANPRFQNSSFHVNSETGTLVFSAVHKEDSGQYYCIASNDAGAARCEGQDMEVYDLNIAGIIGGVLVVLIVLAVITMGICCAYRRGCFISSKQDGESYKSPGKHEGVNYIRTSEEGDFRHKSSFVI
What is the function of this protein?
Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis.
What are the official names of this protein?
Junctional adhesion molecule C, JAM-C, Junctional adhesion molecule 3, JAM-3.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, desmosome. Cell junction, tight junction. Note=Detected in the acrosome region in developing spermatids (By similarity). In epithelial cells, it is expressed at desmosomes but not at tight junctions (By similarity). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (By similarity). SUBCELLULAR LOCATION: [Soluble form of JAM-C]: Secreted.
Protein: RL2_BURP6
Sequence: MAIVKVKPTSPGRRAMVKVVNKDLHKGKPHAALLDTQSSKAGRNNNGRITTRHQGGGHKQHYRVIDFRRTKDGIPAKVERLEYDPNRSANIALVLYADGERRYIIAPKGVTVGQQLMSGSEAPIRAGNTLPIRNIPVGTTIHCIEMLPGKGAQMARSAGTSAMLLAREGLYAQVRLRSGEIRRVHIECRATIGEVGNEEHSLRQIGKAGANRWRGIRPTVRGVAMNPIDHPHGGGEGRTAAGRDPVSPWGTPTKGFRTRRNKRTTTMIVQRRHKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: PSD_DROME
Sequence: MSEELKVVLRRSEQHSGFGFSLLGTTGPPHVIYDIVENSPAADCGAVEAGDVILKVNGTDVHRYTTKEVLKCLRLSEQLVTLELKRDPKLKARIKEQLANTQSPHYVDIESPNIYDYHSSSTNSSPNHRPNAGGKGAATTPSQTGLRYKSPTHLPSLRQNSSPLLASGSTTTTTTATHTHSHSRNSSASSTKIKVVETSITTSTTNVVGLTSPTGSVGGGVGGEATSPTFRPSRIPQALTKCAVPKPVPVLHSPQNKRPRPSQIPTKAANGNGNGHTAHLPPQSLQHSNSYSGSPVTRQRFADREPEREPEPNSAPPQPAKAPRFEAYMMTGDLILNLSRTPQTSNPLPAQAKKIDSLRDSPSRLVNPRINGALAPRASGESSPTSSSSVDSPTNTSSDSVKREAKLLQKQQQQQQQTYQQQQQRDSINNSYNRKDSLTNDTLLMCEELEPDEEGEYVLEEDNKQQRQRQQQQRYRQQQNQQRYEYYQNEDELEEQEEVEEEREEDQTHYDITNIETYQSGVGRGDDDDSDRQCLVDDDDDDDAYDDEENDAGDEDYSTNSLGSGSAKQRLRALKQRTATRQQQRNRDAVDCAGRSGSGSSSTTVKSEAGGLGLDETSFSVPTSPISLSTPLIDKETANSVPTSPEPSSLVPESSSGAGAGAVVVRRHNGHVVRKCDAAGFRTSKSEDHLQQIQREGIAAVIPIDIDEDVNSSLNTLLDTRQDSEDSQSMATVIVNNSSLASNNNEGEQTDNRSSSSSSNSSDNNNCSSNTGEPATSETATATATIITATSTRTMNCSSKLNYILCKKASDRDRIVWTYNAPLQPHQLAALQRQQQQQEQQFQQQQQQLHQQHLQQQQQLQQQHQQQQQQQQQQQQQQLYGQQSHSNSHSSSISSSPQHSAVGSPASPTSVSSSVMSSSGSKGALGLGSSSNGPMAAVQQQQLREREQGGQVAQPPSGIPGLLSCPGGGCGNNGGGGGIGGGGNNDQSVSEAISNISSPDYQDDDNLLSSRDILGGMVLSDPSDSDSTILVSDAAAHQRQQLKQQLRAQQQQQRERERDRDRDREQSEHKVVIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSDVESLHSYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFTFEKKSLDQALREFLQQFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNINRKMSCAEFVDNLADLNDGENFPKDVLKSLYQAIKTKPLEWALDEEAGDLQQQRANNSALGNVGLNPFLDPPELATAVEYKKGYVMRKCCYDSSFKKTPFGKRSWKMFYCTLRDLVLYLHKDEHGFRKSQMSDNLHNAIRIHHALATKANDYTKKQHVFRLQTADQAEYLFQTSDSKELQSWVETINYVCAAISAPPLEGGVGSQKRFQRPLLPSKQSKLMLKEQLDSHEVQLAQLDQELNEHKKGPIPSKGLALQNYKEKESYLQYELRRYRTYVSILSAKMLADQQQLELQAQQPSPASHEEEADTFPVGTTACTPPTPQSINQKDQQKEQQQQQPTNRKEKKKK
What is the function of this protein?
Guanine nucleotide exchange factor for Arf6 (PubMed:28607459).  Regulates axon growth and branching by inhibiting microtubule polymerisation at the cortex (PubMed:31718774).  Together with shot, promotes axonal microtubule bundle integrity (PubMed:31718774).  Required for normal ethanol-induced tolerance and preference (PubMed:28607459).  Probably by activating Arf6, counteracts ethanol-induced sedation (PubMed:28607459).
What are the official names of this protein?
PH and SEC7 domain-containing protein, Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6, Exchange factor for Arf 6.
What is the protein family that this protein belongs to?
Belongs to the PSD family.
What are the subcellular locations of this protein?
Cell projection, axon. Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cell cortex.
Protein: DHE4_PONPY
Sequence: MYRYLGKALLLSRAGPAALGSAANHSAALLGRARGQPAAASQPGLALASRRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGIDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSNVGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFRLQHGSILGFPKAKPYEGSILEADCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDVYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFRDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT
What is the function of this protein?
Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
What are the official names of this protein?
Glutamate dehydrogenase 2, mitochondrial, GDH 2.
What is the protein family that this protein belongs to?
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CRBB2_LITCT
Sequence: MASDHQSPATKQQQPSSKIVLFEQENFQGRCHELSGPCTSLKEAGMEKIGSILVHSGPWVGYEQQNCKGEQFVFEKGEYPRWDSWTNSRKSESISSLRPIKVDSQEHKIVLYENPNFTGKKIEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGYQYLFEKGDYKDSSDFGAQHPQIQSVRRIRDMQWHQRGTFHPTN
What is the function of this protein?
Crystallins are the dominant structural components of the vertebrate eye lens.
What are the official names of this protein?
Beta-crystallin B2, Beta-B2 crystallin, Beta-crystallin Bp.
What is the protein family that this protein belongs to?
Belongs to the beta/gamma-crystallin family.
Protein: CH10_LEIXX
Sequence: MSVSIKPLEDRIVIKQVEAEQTTASGLVIPDTAKEKPQEGVVEAVGPGRIDDNGNRVPLDVAVGDKVIYSKYGGTEVKFGGQDYLVLSARDVLAVVVR
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEPI_ECO27
Sequence: MSEFIAENRGADAITRPNWSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWAISASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGGFLGELIGWRNVFNAAAAMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPFVLALSALVLTLWGSDKIVATGVAIIWGLTFALIPVGWSTWITRSLADQAEKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAKVKMKKS
What is the function of this protein?
Involved in the efflux of purine ribonucleosides, such as inosine and guanosine.
What are the official names of this protein?
Purine ribonucleoside efflux pump NepI.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.