PharMolix/UniProtQA huggingface dataset:
Protein: METK_PSEAB
Sequence: MSEYSVFTSESVSEGHPDKIADQISDAVLDAIIAKDKYARVACETLVKTGVAIIAGEVTTSAWVDLEELVRKVIIDIGYDSSDVGFDGATCGVLNIIGKQSVDINQGVDRAKPEDQGAGDQGLMFGYASNETDVLMPAPICFSHRLVERQAEARKSGLLPWLRPDAKSQVTCRYEGGKVVGIDAVVLSTQHNPEVSYNDLRDGVMELIIKQVLPAELLHKDTQFHINPTGNFVIGGPVGDCGLTGRKIIVDSYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERCEIQVSYAIGVAQPTSISINTFGTGKVSDEKIVQLVREHFDLRPYAITKMLDLLHPMYQPTAAYGHFGRHPFELTVDGDTFTAFTWEKTDKAALLRDAAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_SALPA
Sequence: MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRMVGETGKVILADINDSMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTEKEKALRSMFRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHILPRIGSMVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: GPT_SACS2
Sequence: MRILAILLPILISFFISYITTVWVIRQAKKSRFVGKDINKPDKPEIPLLGGIGIIAGFIAGSFSLLLTDVRSERVIPAVILSSLLIAFLGLLDDIFNVRQSVRAFLPIFASVPLIVYSVGHSIISIPFLGPINFGIFYYIIIIPFALTITSNAFNMLEGLNGLGVGMGIIMLSALAYIGLTHTGPTYQAGLIALSAIFSLSAFLIFNKYPAKIFPGNVGTYFIGALIGAIGIAGFMYTALAILYIPYVVEFILKLRTNFKGVSFGKVDSSGRLYWDEKPHSLTHIVMKMGRFKEYQVVIILWGMEAIFAVIAVILQTTTIVI
What are the official names of this protein?
Putative UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, GlcNAc-1-P transferase, G1PT, GPT, N-acetylglucosamine-1-phosphate transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THIE_PSEA8
Sequence: MKLRGLYAITDSQLLDDGRLLPYVEAALRGGARLLQYRDKSSDQARRLREAESLRELCERYGAQLIVNDDAELAARLGVGLHLGQTDGSLSAARALLGRQAIIGATCHAQLELAEQAVAEGASYVAFGRFFNSSTKPGAPAASVELLDQARPRLPLPITAIGGISLDTAPGLIARGVDLVAVIHALFAAASAAEVERRARAFSALFEPA
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: Y413_METCA
Sequence: MRPPEIPEGHADTSGQFLVAHPKMPANIFAHSVIYVVSHNADGAMGLIVNRLAGAGPLGKLLEAFGLASKAQREIKLYLGGPVGIGQGFVLHSDDYAGASTRALKKGLSLSTGLDVLEAIARGRGPRQVRMLFGYAGWSPGQLDGEIARGDWLLAPADTSLIFSEEPDKVWEEALKHAGLPL
What are the official names of this protein?
UPF0301 protein MCA0413 1.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: RS12_SERP5
Sequence: MATINQLVRKPRSVKAAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLTNGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVKDRKQARSKYGVKKPKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RL24_GLUDA
Sequence: MMAARIKKGDQVVVITGSSKGSRGEVLSVRPDDNKAVVRGVAVAKRHTRPNRMGEQGGIIEKEMPIHLSNLKLVDPKSGKPTRVGFRILEDGRKVRVAKATGEVVEG
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CAR3_DICDI
Sequence: MENLNTTSTAALTGMTKQENDASYAVLLIADFTSIIGCTLVLLGFWRLKLLRNHITKIITFFCSTSLAKDLISTILTLIEKKQSNGSFQCYLYATVITYGSLACWLWTLCLSFSIYNLIVKREPEPEKFEKYYHVFCWVVPFIMSVIMLSKGVIEVTGNWCWIGNTYVGYRFGLFYGPFLAIWFLAAVLVGLTSRYTYKVIRSSVSDNKDRHMTYQFKLINYIIVFLLCWVFAVINRIVNGLNMFPAWVSILHTYLSVSHGFYASVTFIYNNPLMWRYLASIILIPFTKFGYFVETQQRLEKNKNNNNHSPVGLSNNAQNNNHHHNHNNNHNNNHNNHNNNNNNNNSDFVNNDSSNYYTASMIESFSVQNENSKSINGADNFKQNGASQQDDKDSPNSNNNNNNNNNNNNNNNNNNNNNNNNNNYNNKDIEPIDNCNTNSIPMDNIATRIEIPPQHPTLTPQQSLQEINLNDDDNKINTHQSNKKKDSNV
What is the function of this protein?
Receptor for cAMP.  Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes.  The activity of this receptor is mediated by G proteins.
What are the official names of this protein?
Cyclic AMP receptor 3, cAMP receptor 3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 5 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: GUAA_RHOP2
Sequence: MTAPSTPSASSVVPSGADTSPHVAAIHEKILIVDFGSQVTQLIARRVREEGVYSEIVPFQKAEAAFAEMKPKAVILSGGPASVLDADAPAAPMAILEAGVPVLGICYGEQTLAKQLGGTVEAGHHREFGRATIEITDDCALFDGVWQKGGTYDVWMSHGDRVTKLPDGFRGVAKAPGSPISVIADDKRKFYATQFHLEVVHTPDGAKILRNFVRKVAGLTGDWTMRAFREEAIEKIRAQVGTGKVICGLSGGVDSAVAAVLIHEAIGDQLTCVFVDHGMLRKDEAKTVVDLFRHHYNIPLVHVDASETFLGALSGVTDPEQKRKIIGKLFIDVFDAEAKVVGGADYLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRALGRELGLPEIFVGRHPFPGPGLAIRCPGEITAEKLDILRNADAVYIDQIRKAGLYDAIWQAFAVLLPVKTVGVMGDGRTYEYVVGLRAVTSTDGMTADYYPFDMAFLGATATRIINEVKGVNRVVYDVTSKPPGTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: DAPF_ALBFT
Sequence: MRIPFTKMQGAGNDFVVLDETQGRFGLSTAHYRLLADRHFGVGADQILTVRPSPAPGIDFEYLIHNADGAEVEQCGNGARCFARFVRDQGLTAKDAIRVQTRGGVIEPQLNPDGRVTVNMGAPVFELAEIPFDATGLQPQTSGLWKKWPLALVDSGHATTVYVAVVSMGNPHAVQVVDDVDTAPVRLQGPLIEHHASFPKRVNAGFMQIVDRSHIRLRVYERGTGETLACGSGACAAVVAGIRLGLLDDTVHVQTHGGTLTISWAGAAAPVLMTGPATPVFHGEINLPDNL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NA2X_HETHE
Sequence: MAYQKIVFVALMLVLAVSAMRLPDQQDQDISVAKRVACKCDDDGPDIRSATLTGTVDLGSCNEGWEKCASYYTVVADCCRRPRS
What is the function of this protein?
Binds specifically to the voltage-gated sodium channel (Nav) and delays its inactivation.
What are the official names of this protein?
Delta-thalatoxin-Hhe1a, Delta-TATX-Hhe1a, Delta-thalatoxin-Hh1x, Delta-TLTX-Hh1x, Hh X.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type II subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RL31B_PORG3
Sequence: MKKGIHPENYRPVVFKDMSNEDIFITRSTMEAKETIEIDGVTYPLIKVEISNTSHPFFTGKAKLVDTAGRVDKFMSRYGDRNKKK
What are the official names of this protein?
50S ribosomal protein L31 type B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Protein: EX7S_STAA9
Sequence: MTKETQSFEEMMQELEQIVQKLDNETVSLEESLDLYQRGMKLSAACDTTLKNAEKKVNDLIKEEAEDVKNDESTDE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPC24_XENTR
Sequence: MLCEQIKEYVDVSREIVKVMVSDSAAVALKKSLDRQEAMIDLLLDTETEASQLIRDFMAVEEKVAQTLLDTEETKQKTSSKLQKIERELQEKIEKNSSLESGIKFLQKELEELKMMEEEIADMEREADEDTTTVIPSAVYLAKLFHNVTKIDWDYNCDPSLIKGIHYGGEIAQPISIDSNQHSKIFICNYLWSLLSTDW
What is the function of this protein?
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.  Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.  The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
What are the official names of this protein?
Kinetochore protein spc24.
What is the protein family that this protein belongs to?
Belongs to the SPC24 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
Protein: RK12_CYAM1
Sequence: MSTKINSLLEEIKSLTLLEAAELVKQMETTFGIDASAVATAAPAVQVETKKEEKTEFALVLSQVPADKKINVLKVVRTITGLGLKEAKELVDSVPKTLKEGLSASEAEQLKTQLTEAGAQVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L12, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SAHH_METCA
Sequence: MNAVANAASFDDHKVADLSLAGWGRKEIAIAETEMPGLMAIREEYRAAQPLKGARIAGSLHMTIQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAIAADGIPVFAYKGESLDDYWEYTHRILEWPGDVGPNMILDDGGDATLLVTLGARAEKDASLLANPTCEEEEVLFAAIRKRLAAKPGWYSRIQAGIKGVTEETTTGVHRLYEMQAKGRLPFPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKIAVVLGYGDVGKGCAQSLRGLGATVWITEIDPICALQAAMEGYRVVTMDEACDKADIFVTATGNVGVITHDHMVKMKDQAIVCNIGHFDSEIEVAAMRQYTWENIKPQVDHIVLPNGRRIILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFCHGAKYENKVYVLPKHLDEKVARLHLKKIGARLTELSDEQAAYIGVPKEGPYKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCRIA_ORYSJ
Sequence: MASTALSTASNPTQLCRSRASLGKPVKGLGFGRERVPRTATTITCQAASSIPADRVPDMGKRQLMNLLLLGAISLPTVGMLVPYGAFFIPAGSGNAGGGQVAKDKLGNDVLAEEWLKTHGPNDRTLTQGLKGDPTYLVVEADKTLATYGINAVCTHLGCVVPWNAAENKFICPCHGSQYNNQGRVVRGPAPLSLALVHADVDDGKVLFVPWVETDFRTGDNPWWA
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex iron-sulfur subunit, chloroplastic, Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein, Rieske iron-sulfur protein, ISP, RISP.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein. Note=The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.
Protein: COAX_SYNY3
Sequence: METSKPGCGLALDNDKQKPWLGLMIGNSRLHWAYCSGNAPLQTWVTDYNPKSAQLPVLLGKVPLMLASVVPEQTEVWRVYQPKILTLKNLPLVNLYPSFGIDRALAGLGTGLTYGFPCLVVDGGTALTITGFDQDKKLVGGAILPGLGLQLATLGDRLAALPKLEMDQLTELPDRWALDTPSAIFSGVVYGVLGALQSYLQDWQKLFPGAAMVITGGDGKILHGFLKEHSPNLSVAWDDNLIFLGMAAIHHGDRPIC
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RELX_BALAC
Sequence: QSTNDLIKACGRELVRLWVEICGSVRWGQSALRMTLSEKCCQVGCIRKDIARLC
What is the function of this protein?
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.
What are the official names of this protein?
Relaxin.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: METN_POLSJ
Sequence: MIELKSIFQTYKGPTGPVEALRGVDLQINPGEVYGIIGRSGAGKSSLVRVINLLNRPTAGQVLVDGRELTSLNGDALRVARRDIGIIFQHFNLLSSRTVYGNVALPLEIAGLSAGEIKARVEPLLDLVGLSALADRYPAQISGGQKQRVGIARALANRPKVLLSDEATSALDPETTRSILGLLQQINKEFGLTIVLITHQMQVIKQVADRVAVIDAGRIVESGPVIDVFTRPQHDTTRSLIAEIVPQDLPESVLARIRTLMSAGHPEEGQLLRLAFAGDESDRPLLSDVIRRFGIDLSIVHGQVDEIQGKPFGSLAVFARGAREQLNAAVAHLRGAGVHVDQVDGALPGGLAGGFSHVQ
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PMPB_CANBO
Sequence: MAPIKRGDRFPTTDDVYYIPPEGGEPGAFELSKFVKTKKFVVVSVPGAFTPPCTEQHLPGYIKNLPRILSKGVDFVLVITQNDPFVLKGWKKELGAADAKKLIFVSDPNLKLTKKLGSTIDLSSIGLGTRSGRLALIVNRSGIVEYAAIENGGEVDVSTAQKIIAKL
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
What are the official names of this protein?
Putative peroxiredoxin-B, PMP20, Peroxisomal membrane protein B, Thioredoxin reductase, Thioredoxin-dependent peroxiredoxin-B.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx5 subfamily.
What are the subcellular locations of this protein?
Peroxisome membrane; Peripheral membrane protein.
Protein: B2MG_MOUSE
Sequence: MARSVTLVFLVLVSLTGLYAIQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKDWSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system.
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RIMK_SHIB3
Sequence: MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIHYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGDFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIAGKMIRWIERYATTEYCLKTGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: CYAY_DICCH
Sequence: MNDSEFHQLADTLMLKVEETLDQFDGDADIDYETNGGVMTLSFENGSKIVINRQEPMHQVWLATKGGGYHFDYQHGRWICDRSGSDFMALLAQACTEQSGEEIHFD
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: ECOT_YERPG
Sequence: MKKCSIILASVLLATSINAIADTPTPLNQQQPLEKIAPYPQAEKGMSRQVIFLEPQKDESRFKVELLIGKTLNVDCNRHMLGGNLETRTLSGWGFDYLVMDKISQPASTMMACPEDSKPQVKFVTANLGDAAMQRYNSRLPIVVYVPQGVEVKYRIWEAGEDIRSAQVK
What is the function of this protein?
General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
What are the official names of this protein?
Ecotin.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TNFL4_MOUSE
Sequence: MEGEGVQPLDENLENGSRPRFKWKKTLRLVVSGIKGAGMLLCFIYVCLQLSSSPAKDPPIQRLRGAVTRCEDGQLFISSYKNEYQTMEVQNNSVVIKCDGLYIIYLKGSFFQEVKIDLHFREDHNPISIPMLNDGRRIVFTVVASLAFKDKVYLTVNAPDTLCEHLQINDGELIVVQLTPGYCAPEGSYHSTVNQVPL
What is the function of this protein?
Cytokine that binds to TNFRSF4.  Co-stimulates T-cell proliferation and cytokine production.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 4, OX40 ligand, OX40L.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: NDKB_BOVIN
Sequence: MAHAERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLQASEELLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEINLWFKPEELIEYKPCAFDWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).  Negatively regulates Rho activity by interacting with AKAP13/LBC.  Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically.  Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter.  Does not bind to duplex NHE III(1).  Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity.  Binds both folded and unfolded G4 with similar low nanomolar affinities.  Stabilizes folded G4s regardless of whether they are prefolded or not (By similarity).  Exhibits histidine protein kinase activity (PubMed:12486123).
What are the official names of this protein?
Nucleoside diphosphate kinase B, NDK B, NDP kinase B, Histidine protein kinase NDKB.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, lamellipodium. Cell projection, ruffle. Nucleus. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.
Protein: ABNC_ASPFU
Sequence: MYLYTLILLFLASANVNAYANPGACSGNCWTHDPGLYQRKSDGKYFRFATGGGIHIASADSLEGPWTDDGYVLPSGSIIDLDGKTNLWAPDLHYHDGTYYLYYAVSSLGSQNSATGVATSKTMEAGSWTDHGTTGIESTPSSPYNTIDANWIAVGGTQYVNFGSYWNNLFQVEMENGLKVKSGATPHQIAYNASGIHRQEAAFMFERNNYFYLTFSGGIALGYNDTWPAPGEEYFIAVCRSTSATGGFVDKNGVSCLNSGGSLLLSSHDFVYGPGGQGILQDSSKGFVLYYHYADTRIGKAVEDYQFGWNQLKWENDWPSV
What is the function of this protein?
Endo-1,5-alpha-L-arabinanase involved in degradation of pectin.  Its preferred substrate is linear 1,5-alpha-L-arabinan (By similarity).
What are the official names of this protein?
Probable arabinan endo-1,5-alpha-L-arabinosidase C, Endo-1,5-alpha-L-arabinanase C, ABN C.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 43 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HUTI_SALDC
Sequence: MRQLLPGDTVWRNIRLATMDPQRQAPYGLVDNQALIVREGHICDIVPETQLPVSGDNIHDMQGRLVTPGLIDCHTHLVFAGNRAAEWEQRLNGASYQHISAQGGGINATVSATRACAEETLYLLARERMMRLASEGVTLLEIKSGYGLELATEEKLLRVAAKLAAENAIDISPTLLAAHATPAEYRDDPDGYITLVCETMIPQLWQKGLFDAVDLFCESVGFNVAQSERVLQTAKALGIPVKGHVEQLSLLGGAQLVSRYQGLSADHIEYLDEAGVAAMRDGGTVGVLLPGAFYFLRETQRPPVELLRRYQVPVAVASDFNPGTSPFCSLHLAMNMACVQFGLTSEEAWAGVTRHAARALGRQATHGQLRADYRADFVVWDAEQPVEVVYEPGRNPLYQRVYRGQIS
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2B6_CRODM
Sequence: SLVQFEKMIKEVAGKNGVPWY
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that induces a conspicuous local myotoxic effect and moderate footpad edema.  In vitro, it shows anticoagulant effects and is not cytotoxic on myoblast but is able to lyse myotubes.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 crotoxin basic chain, CB, svPLA2, Cdcum6, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPB_PARPJ
Sequence: MCATPVSPTPLPSTTPLTLRWRGSEPYEASFEAMRTFTDERTADTPDEIWLVEHPPVFTLGQAGNPAHLLAADSGIPLVKVDRGGQITYHGPGQVVAYLLLDLRRRKLMVRELVTRIEQAVIDTLAAYNLAGERKAGAPGIYVAPGPDVGLHAGAKIAALGLKIRNGCSYHGVSLNVNMDLRPFLAINPCGYAGLETVDMATLGVAAGWDDVARTFAERLTANLDGSPAAVAQPQAGVLTA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.