PharMolix/UniProtQA huggingface dataset:
Protein: CNTC_STAA8
Sequence: MIILKRLLQDKGAVIALGIIVLYVFLGLAAPLVTFYDPNHIDTANKFAGMSFQHLLGTDHLGRDILTRLIYAIRPSLLYVFVALFVSVLIGSILGFLSGYFQGFVDALIMRACDVMLAFPSYVVTLALIALFGMGAENIIMAFILTRWAWFCRVIRTSVMQYTASDHVRFAKTIGMNDMKIIHKHIMPLTLADIAIISSSSMCSMILQISGFSFLGLGVKAPTAEWGMMLNEARKVMFTHPEMMFAPGIAIVIIVMAFNFLSDALQIAIDPRISSKDKLRSVKKGVVQS
What is the function of this protein?
Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP).  Involved in the import of divalent metals ions such as nickel, cobalt and zinc.  Probably responsible for the translocation of the substrate across the membrane (PubMed:23279021, PubMed:29581261).  Plays a major role in nickel/cobalt import in zinc-depleted conditions.  Contributes to virulence.  Required for full urease activity in vitro (PubMed:23279021).
What are the official names of this protein?
Metal-staphylopine import system permease protein CntC.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TRPA_ACTPJ
Sequence: MSRFDTLFANLKAKNEGAFVPFVTLCDPDFDRSFEIIETLIANGADALELGFPFSDPLLDGSVIQAANKRALDGGYSTDACFEMIAKIRSKYPEIPIGLLLCANLVFVPTQDVFFKRCAETGVDAVLIADVPVLAAEEFTQAAKKHGIQSVFICPPNADQATIERIARLTEGYTYLVSRAGVTSAENQAHAKNLDNLIESLKRSNSAPILQGFGIAKPEQVKEALALGCDGAISGSAIVKIIERNLDSQTQLLSELAKFVSVMKTATKS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: AT1B_ARTSF
Sequence: MAKGKQKKGKDLNELKKELDIDFHKIPIEECYQRLGSNPETGLTNAQARSNIERDGPNCLTPPKTTPEWIKFCKNLFGGFALLLWTGAILCFLAYGIEASSGNEDMLKDNLYLGIVLATVVIVTGIFSYYQENKSSRIMDSFKNLVPQYALALREGQRVTLKAEELTMGDIVEVKFGDRVPADLRVLEARSFKVDNSSLTGESEPQARSPEFTNDNPLETKNLAFFSTNAVEGTMRGIVIGIGDNTVMGRIAGLASGLDTGETPIAKEIAHFIHIITGVAVFLGVTFFIIAFVLGYHWLDAVVFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDGTITEADTTEDQSGAQFDKSSAGWKALVKIAALCSRAEFKPNQSTTPILKREVTGDASEAAILKCVELTTGETEAIRKRNKKICEIPFNSANKFQVSIHENEDKSDGRYLLVMKGAPERILERCSTIFMNGKEIDMTEELKEAFNNAYMELGGLGERVLGFCDYLLPLDKYPHGFAFNADDANFPLTGLRFAGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDIAARLNIPVSEVNPRDAKAAVVHGGELRDITPDALDEILRHHPEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIVYTLTSNIPEISPFLLFILFDIPLPLGTVTILCIDLGTDMVPAISLAYEEAESDIMKRRPRNPVTDKLVNERLISLAYGQIGMIQASAGFFVYFVIMAECGFLPWDLFGLRKHWDSRAVNDLTDSYGQEWTYDARKQLESSCHTAYFVSIVIVQWADLIISKTRRNSVFQQGMRNNILNFALVFETCLAAFLSYTPGMDKGLRMYPLKINWWFPALPFSFLIFVYDEARKFILRRNPGGWVEQETYY
What is the function of this protein?
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane.  This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit alpha-B, Na(+)/K(+) ATPase alpha-B subunit, Sodium pump subunit alpha-B.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: THIE_YERP3
Sequence: MATPGFPSTEQRLGLYPVVDSLLWIERLLAAGVTTLQLRIKNADDAQVEQDIVAAIELGKRYQARLFINDYWQLAVKHGAYGVHLGQEDLETADLAAIQQAGLRLGISTHDEHELAVAKTLRPSYIALGHIFPTQTKQMPSSPQGLASLSRQVKNTPDYPTVAIGGISIERVPHVLATGVGSVAVVSAITLASDWQRATAQLLHLIEGKELADEK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: HCP_ECOHS
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLAVDANARVDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECSMEIGQMNFKVMSILDAGETGKYGHPTPTQVNVKATAGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVRHLDGDDFSAVITQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIFLLGGCDGARGERHYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFLTPDLLAVLNEKFGLRSITTVEEDMKQLLSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_CORGB
Sequence: MSEANVNNQEKSTRKVRTGYVVSDKMQKTIVVEVEDRKQHALYGKILRSAKKVKAHDEEQIAGIGDLVRIEETRPLSKDKNYRLIEIVEKAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ENO1_ARATH
Sequence: MALTTKPHHLQRSFLSPSRVSGERYLESAPSCLRFRRSGVQCSVVAKECRVKGVKARQIIDSRGNPTVEVDLITDDLYRSAVPSGASTGIYEALELRDGDKSVYGGKGVLQAIKNINELVAPKLIGVDVRNQADVDALMLELDGTPNKSKLGANAILGVSLSVCRAGAGAKGVPLYKHIQETSGTKELVMPVPAFNVINGGSHAGNSLAMQEFMILPVGATSFSEAFQMGSEVYHTLKGIIKTKYGQDACNVGDEGGFAPNVQDNREGLVLLIDAIEKAGYTGKIKIGMDVAASEFFMKDGRYDLNFKKQPNDGAHVLSAESLADLYREFIKDFPIVSIEDPFDQDDWSSWASLQSSVDIQLVGDDLLVTNPKRIAEAIKKQSCNALLLKVNQIGTVTESIQAALDSKAAGWGVMVSHRSGETEDNFIADLSVGLASGQIKTGAPCRSERLSKYNQLLRIEEELGNVRYAGEAFRSP
What are the official names of this protein?
Enolase 1, chloroplastic, 2-phospho-D-glycerate hydro-lyase 1, 2-phosphoglycerate dehydratase 1.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BAAT_MOUSE
Sequence: MAKLTAVPLSALVDEPVHIQVTGLAPFQVVCLQASLKDEKGNLFSSQAFYRASEVGEVDLEHDPSLGGDYMGVHPMGLFWSLKPEKLLGRLIKRDVMNSPYQIHIKACHPYFPLQDIVVSPPLDSLTLERWYVAPGVKRIQVKESRIRGALFLPPGEGPFPGVIDLFGGAGGLMEFRASLLASRGFATLALAYWNYDDLPSRLEKVDLEYFEEGVEFLLRHPKVLGPGVGILSVCIGAEIGLSMAINLKQIRATVLINGPNFVSQSPHVYHGQVYPPVPSNEEFVVTNALGLVEFYRTFQETADKDSKYCFPIEKAHGHFLFVVGEDDKNLNSKVHANQAIAQLMKNGKKNWTLLSYPGAGHLIEPPYTPLCQASRMPILIPSLSWGGEVIPHAAAQEHSWKEIQKFLKQHLLPDLSSQL
What is the function of this protein?
Catalyzes the amidation of bile acids (BAs) with the amino acid taurine (PubMed:9215542).  Selective for taurine conjugation of cholyl CoA and only taurine-conjugated BAs are found in bile (PubMed:9215542).  Amidation of BAs in the liver with taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity).  This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity).  May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity).  In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity).
What are the official names of this protein?
Bile acid-CoA:amino acid N-acyltransferase, BACAT, BAT, Bile acid-CoA thioesterase, Choloyl-CoA hydrolase, Glycine N-choloyltransferase, Long-chain fatty-acyl-CoA hydrolase.
What is the protein family that this protein belongs to?
Belongs to the C/M/P thioester hydrolase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Peroxisome.
Protein: RL35_CLOB8
Sequence: MPKMKTHRGAAKRFRKTGTGKLKRGKAFRSHILTKKSSKTKRHLRKAGYVSDSQLKVMKKLLPYL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: WBP1L_MOUSE
Sequence: MPFLWGLRQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTVVIILSCCCVCHHRRAKHRLQAQQRQHEINLIAYREAHNYSALPFYFRFLPNSLLPPYEEVVNRPPTPPPPYSAFQLQQQQQLLPPPPQGGPPGGSPPGADPPPQGSQGAQSSPLSGPSRSSTRPPSVADPQSPEVPTDREATKASGTESGSPMAGHGELDPGAFLDQDSECKEELLKDSRSERGGVSPDSEDKTPGRHRRFTGDSGIEVCVCNRGHHDDDLKEFNTLIDDALDGPLDFCDSCHVRPPVDEEEGLCLSSEGQAREHGHPHLPRPPACLLLNTINEQDSPNSQHSGSPS
What are the official names of this protein?
WW domain binding protein 1-like, Outcome predictor in acute leukemia 1 homolog.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PIMT_STRM5
Sequence: MSPRLRLQPEAVGIGMTSQRVRDRLVDRLREAGIVDESTLNAIRVVPRHLFIDEALASRAYEDTALPIGHGQTISQPWVVARMTEAVLQVAPKRVLEVGTGSGYQAAVLGALGLEVYTVERIGDLLRQARKRFRALGMNIRTKHDDGRVGWAEHGPFDAIVVTAAAPALVDVLIEQLAEGGRLVAPVGGPSAQSLVQLDRRADGSIEQHVLAPVTFVPLLSGMLD
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_PLAGE
Sequence: MTNIRKTHPLLKILNSSFVDLPAPSNLSAWWNFGSLLGVCLAXQILTGLFLAMHYTADTATAFNSVTHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGLYYGSYLYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTELVQWIWGGFSVDKATLTRFFAFHFMLPFIVVALVMIHLLFLHETGSNNPTGIPSDPDLIPFHPYYTIKDILGFLVMLTILSTLVLFSPDLLEDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILVIVPTLHTSKQRSMMFRPLSQCLFWFLVATLLTLTWIGGQPVEYPYVIIGQVASILYFMILLVFMPLISIVENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TRPF_PELPD
Sequence: MIKVKICGITNLEDALLAVDAGADALGFVFCEASPRSVTPEQAASIIRQLPPFIQTIGLFVNEPLAVINQTADACGLDIVQLHGEEAPQFCAGVKRRVIKALRVRDESSLEPMTSYRVSAFLLDAWSPSAHGGTGRTFNWDIAAGAAAKNRIVLAGGLTADNIAAAIRKVHPYGVDVSSGVEAAPGKKDAVKIREFIRIAKETRSESTR
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: GUAA_CHLPD
Sequence: MQSVTVLDFGSQYTQLIARRIRELGIYSEILPYNASPETIREHDPKAIILSGGPTSVYGDSALLPDGGVFMLGVPVLGICYGLQAIAKHFGGEVAGSSKQEFGRAKMLVSHNEESESPLFRNIPDSDVWMSHGDKVVRLPEGFRVTASSENSEMCALESYGSKAALKVYGLQFHPEVQHTLYGKQLLSNFLIDIAGIKPDWSPKSFIGHQIEEIRARAGKDKVICGISGGVDSTVAAVLVSQAIGKQLHCVFVDNGLLRKNEAVKVMNFLKPLGLSVTLADASDLFLKRLDKVASPEKKRKIIGRTFIHVFEQHLNEEKYLVQGTLYPDVIESVSVKGPSETIKSHHNVGGLPKRMKLKLIEPLRELFKDEVRAVGRELGIAEDILMRHPFPGPGLAVRVLGSVSRPRLDILREADEIFIEELKTSGLYQHVWQAFSVLLPVQSVGVMGDKRTYENVLALRAVESTDGMTADWAQLPHDFLARVSNRIINEVRGINRVAYDISSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: TRI75_HUMAN
Sequence: MAVAAALTGLQAEAKCSICLDYLSDPVTIECGHNFCRSCIQQSWLDLQELFPCPVCRHQCQEGHFRSNTQLGRMIEIAKLLQSTKSNKRKQEETTLCEKHNQPLSVFCKEDLMVLCPLCTQPPDHQGHHVRPIEKAAIHYRKRFCSYIQPLKKQLADLQKLISTQSKKPLELREMVENQRQELSSEFEHLNQFLDREQQAVLSRLAEEEKDNQQKLSANITAFSNYSATLKSQLSKVVELSELSELELLSQIKIFYESENESSPSIFSIHLKRDGCSFPPQYSALQRIIKKFKVEIILDPETAHPNLIVSEDKKRVRFTKRKQKVPGFPKRFTVKPVVLGFPYFHSGRHFWEIEVGDKSEWAIGICKDSLPTKARRPSSAQQECWRIELQDDGYHAPGAFPTPLLLEVKARAIGIFLDYEMGEISFYNMAEKSHICTFTDTFTGPLRPYFYVGPDSQPLRICTGTVCE
What is the function of this protein?
May play a role in female meiosis.
What are the official names of this protein?
Tripartite motif-containing protein 75.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle.
Protein: TSAD_CITK8
Sequence: MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQAALKESGLTAKEIDAVAYTAGPGLVGALLVGATVGRSLAFAWNVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTQLISVTGIGQYALLGESIDDAAGEAFDKTAKLLGLDYPGGPMLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRSNGDDEQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMQKRRGEVFYARPEFCTDNGAMIAYAGMVRFKAGATADLGVSVLPRWPLAELPAA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHSD_RICCN
Sequence: MVYDFKAEIVKAKNSGSAKSGSHHWLLQRVTGIILALCSVWLIYFTLTNKNNDINIIMLWELKKPFNVVALLITVVISLYHAMLGMRVVIEDYISYHKLRNTLIIIVQLFCIVTIVAFVVALFYKG
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase hydrophobic membrane anchor subunit.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YQHA_ECO24
Sequence: MERFLENAMYASRWLLAPVYFGLSLALVALALKFFQEIIHVLPNIFSMAESDLILVLLSLVDMTLVGGLLVMVMFSGYENFVSQLDISENKEKLNWLGKMDATSLKNKVAASIVAISSIHLLRVFMDAKNVPDNKLMWYVIIHLTFVLSAFVMGYLDRLTRHNH
What are the official names of this protein?
UPF0114 protein YqhA.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LPXC_DECAR
Sequence: MLKQRTLKTVIRASGVGLHGGVKVNMTLRPAAPDTGIVFRRVDLPEPVDIPAKAFMVGDTRMCSCLEKDGVKVGTIEHLMSALAGLGIDNVWVDLDAPEVPILDGSAAPFVFLIQSAGIEEQNAAKKFIRVTKTIEVRDGDKWARFEPYDGYRLAFSIVFNHPAIDKSAQKAEIDFAEQSYVREVARARTFGFMQEVEYLRENGLALGGGLENAIVLDEFRVLNQDGLRYGDEFVKHKILDAIGDLYLLGHPLLAAYSSHKGGHALNNQLARALLEQQSSWEIATFEQAEHAPSGVTRWLAQAAA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: WASH1_DROME
Sequence: MEESPYLHSPYQVAIIATDLHHEDTIIQAAQSLDCLHKTINSIFERIDARLARNGSKVEDINNRVKRAQAKIDALVGSKRAIQIFAPARFPASDVLAPLPATFPQVAANPLMEQQVDQLPQGTYSSHSAADQKPDDADIFFHVRGDREQESPLVAERKITNRTAGLGILPAGGVRSVPSLMRFNTNEFAYGEDLNAWKRSLPPQNARRVASQSTQLTGEKQLAPAPHSLAHGTTKLATPAGDLRYNPAALAAPAIDVPLDLPDLPGIANDLQYEPVEEQTPIAPSQQFGDLPELPDLGLEEQDIIVQAIAAQTHIPGPVRRKSVGQCPSPVTAAPPPPPPPPPPPPPPPPAQTSAIPSPPPFPTKGAVKPLSPSLATPLNMPQPPPATEDPRSELMAAIRNAGGVHGGRLRSPAAAPLDVVDNSRSKAGGAVTGDLMADLHNKLMLRRKGISGSQNPVEATAGNPLMQQLSRVIPPPVQPRKGSKSSDEHSEDDEDGWN
What is the function of this protein?
Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization (PubMed:19633175).  Participates in both linear- and branched-actin networks (PubMed:19633175).  Functions in linear-filament (bundled F-actin) by acting downstream of Rho1 and regulating actin and microtubule organization during oogenesis (PubMed:19633175).  Nucleates actin in an Arp2/3-dependent manner and exhibits F-actin and microtubule bundling and cross-linking activity in the egg chamber (PubMed:19633175).  During embryogenesis, acts downstream of Rho1 to activate the Arp2/3 complex which is necessary for the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458).  Its function in hemocyte transmigration is independent of the WASH complex (PubMed:25739458).  May play a role in endosomal sorting; its assembly in the WASH complex may regulate its nucleation-promoting factor (NPF) activity.
What are the official names of this protein?
WASH complex subunit 1, Protein washout, WAS protein family homolog 1.
What is the protein family that this protein belongs to?
Belongs to the WASH1 family.
Protein: DGTL1_CLOPE
Sequence: MKIRENIENFERIKLNKVAKFSDESVGRERLEEPDEIRTCFMVDRDRIIHSKSFRRLKRKTQVFIRTYGDHYRTRLVHTLEVSQVARTIGVALSLNEYLIEAIALGHDLGHAAFAHIGEDVLNDFLPGGFKHNEQSVRVAKKIEKNGLGLNLTKEVLDGILNHSGFSNVSKVAGTFEGQVVRFADKIAYVNHDIDDSIRAGILKEDDLPKNIIEILGASGSERIDTLVKDCVFNTIDNIDKGEPRVSLSKEIGDAFVQLRKFLFDNIYLGKYLEDERKKAEFVLEKVIEYYYNNWEEMPDLYRNICEEEGIHRGVTDYVAGMTDDYCTNEFNKIYIPKFVMY
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: G3P3_TRIV2
Sequence: MKIRVGINGFGRMGRLALRAAWGWPELEFVHINEIKGGAVAAAHLLKFDSVHGRWTPEVEAEGERVLIDSTPLSFSEYGKPEDVPWEDFGVDLVLECSGKFRTPATLDPYFKRGVQKVIVAAPVKEEALNIVMGVNDYLYEPEKHHLLTAASCTTNCLAPVVKVIHEGLGIKHGIITTIHDNTNTQTLVDAPHKDLRRARATSLSLIPTTTGSATAIALIYPELKGKLNGIAVRVPLLNASLTDCVFEVNRPTTVEEINALLKAASEQAPLQGILGYEERPLVSIDYKDDPRSSIIDALSTMVVDETQVKILAWYDNEWGYVNRMVELARKVALSLK
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 3, GAPDH 3, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPS1_LITPI
Sequence: KPKEDREWEKFKTKHITSQSVADFNCNRTMNDPAYTPDGQCKPVNTFIHSTTGPVKEICRRATGRVNKSSTQQFTLTTCKNPIRCKYSQSNTTNFICITCRDNYPVHFVKTGKC
What is the function of this protein?
Endonuclease, hydrolyzes highly polymerized RNA, poly(U) and poly(C), and the dinucleotides CpA and UpA.  More active towards rCA than rUA or rUG.  Has cytotoxic activity against cultured human submaxillary gland carcinoma cells.
What are the official names of this protein?
Amphinase-1.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRUD_PSEAB
Sequence: MSVLGELDLLGPRAHGAACGEAVLKAVAEDFQVDEVLDIPLSGEGEHLWLWVEKRGLNTEEAARRLGRAAGVQQKNVSYAGLKDRQALTRQWFSLHLPGKADPDLGAAEGADLRILRRTRHSRKLQRGAHAANGFTLRLTGLRAERALLDARLERIAADGVPNYFGLQRFGHGGGNLVDARSCAEQDLLPANRNLRSRFLSAGRSYLFNRLLAERVAEGSWNRAAVGDLLAFTDSRSFFLAGEEECRDARLAALDLHPTGPLWGEGDPPSGAGVLDRELALAGSEPALCRWLAKAGMAHERRILRLPIQGLAWHYPEPDVLQLEFVLPAGCFATVVVREILDLVPTGQTENPCAY
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase D, tRNA pseudouridine(13) synthase, tRNA pseudouridylate synthase D, tRNA-uridine isomerase D.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruD family.
Protein: IF5A5_SOLTU
Sequence: MSDEEHHFESKADAGASKTYPQQAGTIRKSGHIVIKNRPCKVVEVSTSKTGKHGHAKCHFVAIDIFTGKKLEDIVPSSHNCDVPHVNRTDYQLIDISEDGFVSLLTENGNTKDDLRLPTDDTLLAQVKDGFAEGKDLVLSVMSAMGEEQICGIKDIGPK
What is the function of this protein?
The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Eukaryotic translation initiation factor 5A-5, eIF-5A-5, eIF-4D.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
Protein: ARGJ_YEAS6
Sequence: MRISSTLLQRSKQLIDKYALYVPKTGSFPKGFEVGYTASGVKKNGSLDLGVILNTNKSRPSTAAAVFTTNKFKAAPVLTSKKVLETARGKNINAIVVNSGCANSVTGDLGMKDAQVMIDLVNDKIGQKNSTLVMSTGVIGQRLQMDKISTGINKIFGEEKFGSDFNSWLNVAKSICTTDTFPKLVTSRFKLPSGTEYTLTGMAKGAGMICPNMATLLGFIVTDLPIESKALQKMLTFATTRSFNCISVDGDMSTNDTICMLANGAIDTKEINEDSKDFEQVKLQVTEFAQRLAQLVVRDGEGSTKFVTVNVKNALHFEDAKIIAESISNSMLVKTALYGQDANWGRILCAIGYAKLNDLKSLDVNKINVSFIATDNSEPRELKLVANGVPQLEIDETRASEILALNDLEVSVDLGTGDQAAQFWTCDLSHEYVTINGDYRS
What is the function of this protein?
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
What are the official names of this protein?
Arginine biosynthesis bifunctional protein ArgJ, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ArgJ family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GATE_SULAC
Sequence: MTELDYSKLGLKVGLEIHQQLNTNKKLFCDCSTTLDEKHHGTLQRYLRPSFSEIGEIDTAALFEWQKGKKYLYQIPFNSCLVEADEEPPHGLNREALAVVLAVAMSLESNIVDEIYVMRKIVIDGSDTTGFQRTSIVAMGGQVIVEGKKIGIQTIALEEDAARKISESANETMYSLDRLGIPLIEISTAPDITTPEEAEKVAFRIGQLLRLTGKVKRGIGTIRQDLNVSIQGGVKTEIKGVQRLELIPEIIKNEARRQYELLKIKDELVNKRGLSKTIVENEIKELELTHLFRNTNSKIIKKELEKGGLIYGIKFKGFKGIFGRELMPNRRFGTEIADYVRALAELGGIFHSDELPNYGITSEEVESVKKELGIGENDGFVLVIGDKEKLKVAITKIKERVLYAFVGVPKETRVALDDGTTKFMRPQPGSARMYPETDIIPIKIDESILNFAKSFVPENPETKLRKLIEMGLSKELATEILNSPRLDLFEELSKKYSPKVSPIVIATTLENYIKYAKSKGGDISVITDEVIEEIINALYNDKISKDSIQEILVDYSTSKKPIRNIVDNYAKITDEELNRIIDKILDENKDIINQKGEKAFNVIIGKVMNVVKGRAEGKKVVDTLKLKMKNYPRT
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit E, Glu-ADT subunit E.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatE subfamily.