PharMolix/UniProtQA huggingface dataset:
Protein: HIS6_NOCSJ
Sequence: MTLAVRVIPCLDVDAGRVVKGINFKELRDAGDPVELARTYDAEGADELTFLDISASFEGRATTMEIVSRTAEEVFIPLTVGGGVSSVADVDRLLRAGADKVAVNTAAINRPELVAEIADRFGNQVLVLSVDARRVDARRAPGTASGFEVTTHGGRKSAGLDAVEWAVRAADLGAGEILLNAMDADGTQDGFDLELIRAVRREVTVPVIASGGAGAVEHFPPAVEAGADAVLAATVFHFGTLRIADVKASLAGAGYPVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLO2_SALA4
Sequence: MNLNSIPAFQDNYIWVLTNDEGRCVIVDPGEAAPVLKAIAEHKWMPEAIFLTHHHHDHVGGVKELLQHFPQMTVYGPAETQDKGATHLVGDGDTIRVLGEKFTLFATPGHTLGHVCYFSHPYLFCGDTLFSGGCGRLFEGTPSQMYQSLMKINSLPDDTLICCAHEYTLANIKFALSILPHDSFINEYYRKVKELRVKKQMTLPVILKNERKINLFLRTEDIDLINEINKETILQQPEARFAWLRSKKDTF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: RS4_BURM7
Sequence: MARYIGPKAKLSRREGTDLFLKSARRSLADKCKLDSKPGQHGRISGARTSDYGTQLREKQKVKRIYGVLERQFRRYFAEADRRKGNTGETLLQLLESRLDNVVYRMGFGSTRAEARQLVSHKAITVNGIVANIPSQQVKAGDVVAIREKAKKQARIVEALSLAEQGGMPSWVAVDAKKFEGTFKQVPERADIAGDINESLIVELYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RFA1A_ORYSJ
Sequence: MAMARLTPNGVAAALAGDTNLKPVLQIVELRGVQVNGAGVTRGERFRAVVSDGTAASSALFAAQLSDHARSGALRRGSIVQLSEYVINEVGPRRIIVILNLEVLVSECEIIGNPTALSETGSPIPNPTRVEQFNGAPQYGLMAGNSSNTTTKPSDNVPLFQNSMAGNSSNFATRPSDKVPVFQPTVQPSYRPAPNYKNHGAIMKNEAPARIIPISALNPYQGRWAIKARVTAKGDIRRYHNAKGDGKVFSFDLLDSDGGEIRVTCFNALLDRFYEVVEVGKVYVVSRGNLRPAQKNYNHLNNEWEILLENGSTVDLCPDENSSIPTQRFDFRPINEIEDAQNNAILDIIGVVTSVNPCTTIQRKNGMETQKRTMNLKDMSGRSVEVTMWGDFCNREGSQLQGMVERGIFPVLAVKAGKVSDFSGKSVGTISSTQLFINPDSAEAHSLRQWFDSGGRDASTQSISRDITPGASRNEIRKTVAQIKDEGLGMGDKPDWITVKATVIFFKNESFFYTACPNMIGDRQCNKKVTKSTNGNWTCDKCDREFEECDYRYLLQFQIQDHSGTAWVTAFQEAGQELLGCSATELNALKEREDPRFADTMLNCLFQEYLLRLKVKEESYGDERKVKNTAVKVEKVDPSGESKFLLDLISKSSALH
What is the function of this protein?
Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication.  The activity of RPA is mediated by single-stranded DNA binding and protein interactions.  Plays an essential role in meiotic and somatic DNA repair, but is dispensable for DNA replication and homologous recombination.  Is essential for normal progression through meiosis in pollen mother cells.  Is involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
What are the official names of this protein?
Replication protein A 70 kDa DNA-binding subunit A, OsRPA70a, Replication factor A protein 1A, Replication protein A 1A.
What is the protein family that this protein belongs to?
Belongs to the replication factor A protein 1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACPS_SALTI
Sequence: MAILGLGTDIVEIARIEAVISRSGERLARRVLSDNEWAIWETHQQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPRLRLWGEALTLAEKLGVAHMHVTLADERHYACATVILES
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYTSA_TETNG
Sequence: MKKSVRPAASKVSGERGKPEVAGNAAAGKPASKSSTAAPLSKVKSSDDLLAAMAGGNPASCNAVSKSKRTTSVGTTASTLDSKPKTASGTTSKRLASSLSKETNLTRDRLRTSRASANKKQSAAGPVGGDAASGKRSRGQTLAESEGRMSKSKSDGQISDKVALETKVKDLLGLAKSKDVEILHLRSELRDMRAQLGLGGEEPQEGAVEEEKPHVSAITAADVESTLILLQEQNQAIREELNLLKSENRMLKDRLNALGFSLEQRLDGSDKLFSYASLSPDLAAGSGQSDGGGTGTLASSVEGSAPGSLEDLLTGHQHGGSADNLDSESSEVYQAVTSSDDALDAPSGASSSSESECAPSRERSRRGSSGNASEVSVACLTERIHQMEENQHSTAEELQATLQELADLQQITQELNGENERLGEEKVILMDSLCQQSDKLELYGRQIEYLRSLLDEHHVSYVLEEDIKSGRYMELEQRYADLAENGRFEREQLLGVQQHLSNTLKMAEQDNAEAQEMIGALKERNHQMERIMESERQGRAAVEATLEEYKEVASSDQAELSRCRAQLEQERQRVAELYSLHTAGDKNDICQLLEGVRLGKEEAEAKAAKLQEGLEQAHGELSHLRETFSKLDREYREFQEQAQQQMGEQERALEKQRLDLQEKETEVADMKETIFELEDEVEQHRALKLHDNLIITDLENSVKKLQDQKHDMEREIKILHRRLREESMEWRQFQADLQTAVVIANDIKSEAQEEIGDLRRRLQEAQEKNEKLSKELEEVKSRKQDEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPSPTVKTLIKSFDSASQGPPSSGASVTPTASAAPLPRTPLSPSPMKTPPAAAVSPIQRHSVSGSMSAAKPLSSLGDKRPTYPDISLPAEHLLRGSAAGRPPSALQRVSNMDSTKAISVSRRSSEEMKRDMAAPDGASSASLMAMSAASSPLALASSSPTASVTPTTRSRLREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQNIDITNFSSSWNDGLAFCAVLHTYLPAHIPYQELTSQEKRRNFTLAFQAAESVGIKCTLDINEMVHTERPDWQSVMTYVTAIYKYFET
What is the function of this protein?
Involved in cytokinesis and spindle organization.  May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).
What are the official names of this protein?
Cytospin-A, SPECC1-like protein, Sperm antigen with calponin homology and coiled-coil domains 1-like.
What is the protein family that this protein belongs to?
Belongs to the cytospin-A family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell junction, gap junction. Note=Colocalizes with beta-tubulin, acetylated alpha- tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center (By similarity).
Protein: JADE1_MOUSE
Sequence: MKRGRLPSSSEDSDDNGSLSTTWSQHSRSQHGRSSTCSRPEDRKPSEVFRTDLITAMKLHDSYQLNPDDYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIASSGSEPPALGYVDIRTLADSVCRYDLNDMDAAWLEVTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEEGLGEGAAQENGAPESSPQSPLEPYGSLEPNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFTQYTKLLEQEKVSGVPSSCSSALENMLFFNSPSVGPNAPKIEDLKWHSAFFRKQMGTSLVHPLKKSHKRDAVQNSSGTEGKTSHKQPGLCGRREGLEVSESLLSLEKTFAEARLLSSAQQKNGVVTPDHGKRRDNRFHCDLVKGDLKDKSFKQSHKPLRSTDTSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLVKVPITPASPVKSWGGFRIPKKGERQQQGEAHDGACHQHSDCSHLGVSRAPAKERAKSRLRADSENDGYAPDGEMSDSESEASEKKCIHASSTISRRTDIIRRSILAS
What is the function of this protein?
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity.  Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation.  May also promote acetylation of nucleosomal histone H4 by KAT5.  Promotes apoptosis.  May act as a renal tumor suppressor.  Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
What are the official names of this protein?
Protein Jade-1, Jade family PHD finger protein 1, PHD finger protein 17.
What is the protein family that this protein belongs to?
Belongs to the JADE family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to the ciliary transition zone.
Protein: FMAA_DICNO
Sequence: MKSLQKGFTLIELMIVVAIIGILAAFAIPAYNDYIARSQAAEGLTLADGLKVRISDHLESGECKGDANPASGSLGNDDKGKYALATIDGDYNKDAKTADEKNGCKVVITYGQGTAGEKISKLIVGKKLVLDQFVNGSYKYNEGETDLELKFIPNAVKN
What is the function of this protein?
Major component of the type IV fimbriae that plays an essential role in twitching motility, natural transformation, and protease secretion.
What are the official names of this protein?
Type IV major fimbrial protein FimA, 198 antigen, Pilin, Serogroup A1.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.
Protein: TRPD_PSEPK
Sequence: MDIKSALSRIVGQLDLTTEEMREVMRQIMTGQCSEAQIGAFLMGMRMKSESIDEIVGAVSVMRELAEKVELQSLDGVVDIVGTGGDGANIFNVSTASSFVLAAAGCPVAKHGNRAVSGKSGSADLLEAAGIYLNLTPTQVARCIDSLGIGFMFAQSHHSAMKHAAGPRRELGLRTLFNMLGPLTNPAGVKHQVVGVFAQTLCRPLAEVLQRLGSKHVLVVHSKDGLDEFSLAAPTFVAELKNDEITEYWVEPEDLGMKSQSLHGLAVESPQASLELIRDALGRRKTENGQKAAEMIVLNAGAALYAADHAMSLKAGVELAHDVLHTGLAWEKLQELGAFTAVFKVENEA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: 3MGH_HERA2
Sequence: MSKILSAEFHQRHSLVVARELLGCSLVRRLATGEELRGRIVETEAYTPDDPSCHAHRRNTPRARSMFALGGISYVYIIYGIYHCLNVVTQGLGEGAAVLIRAIEPLSGNATMAQLVQKDPANPMRIASGPGMVCRALAVDKSLDGVDLSSQQAGLWFEQGPSLPDQAILQTPRIGINSDPHTVAAPWRLIVADSKALSGTRRQNQGQAYQAQPDWFQKQAI
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: TPM_MYTED
Sequence: MDAIKKKMVAMKMEKENALDRAEQLEQKLRETEEAKAKIEDDYNSLQKKSIQTENDLDNTQTQLQDVQAKYETTEKQIAEHEQEIQSLTRKISMLEEDIMKSEERYTTAASKLEEASKAADESERNRKVLENLNCGNDERIDQLEKQLTEAKWIAEEADKKYEEAARKLAITEVDLERAEARLEAAEAKVIDLEEQLTVVGANIKTLQVQNDQASQREDSYEETIRDLTNRLKDAENRATEAERTVSKLRKEVDRLEDELLTEKEKYKAISDELDATFAELAGY
What is the function of this protein?
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
What are the official names of this protein?
Tropomyosin.
What is the protein family that this protein belongs to?
Belongs to the tropomyosin family.
Protein: GLGB1_XANAC
Sequence: MSNRWDSGVVRALAEARHGDAFAVLGAHPSDKGRLLRTYLPGADRVGAVLDDGQVVALDAGPEPGLFAGELPAHGGYRLRIGWPGGEQETADPYAFGPQLSDFDLHLISEGHHLQLADALGANVVEVEGVRGTRFAVWAPNASRVAVVGDFNSWDARRHPMRLRHQSGVWELFVPDVGPGAHYKYQLRGPHGHELPAKADPVARRAELAPGTASIVADPTPHQWSDDGWMATRARRQAHDAPMSIYEIHAGSWLREAGVDLDWDGLADRLIPYVADMGFTHVELMPVSEHPFGGSWGYQPLGLFAPTARFGTPDGFARFVDRCHREGIGVIVDWVPAHFPTDAHGLAHFDGTALYEHADPREGFHRDWNTLIYNHGRREVSGFLIASAMEFLQRYHVDGLRVDAVASMLYRDYSRNAGEWIPNIHGGRENYETIAFLRRLNEVVREHTPGAVMIAEESTAFPGVTAEVAHGGLGFHYKWNMGWMHDTLHYAGLDPIYRRYHHGELTFSMVYAYSERFVLPISHDEVVHGKGSLLGRMPGDDWQRFANLRAYLGFMFTHPGRKLLFMGCEFGQPTEWNHDAGLPWHLLDDPRHRGVQTLVRDLNRLYVQYPALHAHDDDPSGFAWVVGDDAGNSVVAFLRKGKRGDAPVLVVINFTPVVQHAYRIGVPQGGQWREVFNSDAGIYGGSNLGNGGSVTAEQQSMHGHAQSLPLLLPPLGAIVLTPYG
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB 1, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase 1, Alpha-(1->4)-glucan branching enzyme 1, Glycogen branching enzyme 1, BE 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: CMOB_PSEA8
Sequence: MIQHLALDALQRHLAGSPLYGWATSLPAQIAARIEEGHGDLARWWSAVQRLPQVPAPKVELAQRFALHSDHDAALQAQVKEALQGLIPWRKGPFDFFGVQVDTEWRSDWKWERVSPHVELRGKRVLDVGCGNGYYQWRMLGAGAESVVGVDPNWLFLCQFLAAKRYLPELPAWHLPLALEDLPEKLEGFDTVFSMGVLYHRRSPIDHLLALKDCLKRGGELVLETLVVEGDASTVLVPEDRYAQMRNVWFLPSVAALELWLRRAGFADARCVDVSLTSVEEQRSTEWMRFQSLPEFLDPQDRSRTVEGLPAPMRATLVARKP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: QUEA_CAMFF
Sequence: MSDIFSLSSYDYKLPQDLIATAPTMPKEEARLLVYDRQKDSVFHLKFKNLSEILPECAIIFNDTKVIKARIYGRKDSGAEIQMLLNQPLQNSLFSCYIRGKVKVGTKLKFDLGVEAEVLELKDDSSRIVKFKKNEQILNTSEIYNILSHIGHVPLPPYIKREDTPDDEIWYQSIFAKNEGAVAAPTASLHFNDQMLDDLNKTHDISYITLHVGAGTFKGVEHCDIREHKMHSEFYCISKKAKNIIDSDIKLLGVGTTVTRCIEYYYRTKQPKGFCDLFLHPDNKPLRQDFLLTNFHLPKSTLIMLVASFIGLEKTMEIYKQAVENRYKFYSYGDGMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APLF_BOVIN
Sequence: MSGGFELQPQDGGPRVALAPGETVIGRGPLLGLHRNPCYYQSSEKSQLLPLKTNIWCWLNPGDHFSLLVDKYIFCVLSTHSEMEMECTLRNSQMLDEDDILNEIPKSSSADLPDKTPSAPRRERSTETAKPQAAANNMSFIGESRDLSKQQPNPSERKRILPAWMLTENSSDQNLSVISGGNNVTWESEKERVCKDKTQVNITQPGKKRLISSGSSESTSAKQDTGKKCKNDDQEESIISSKEMPQSFSAAMLHNTEIDNTKTNPQRSKVPVEALGKVSEHKIITKGSSNEDSTARSCSESYSSTQSKSFCDKPQKSHPEPSSNPPSPECVQAKATDSVPNGSEENKVQRTSCMYGANCYRKNPVHFQHFSHPGDSDYGGVNITCQDEADDRPECPYGASCYRKNPQHKIEYRHSTFPVRSISDEDDNVGQPNEYNLNDSFIDDEEEEYEPTDEDSDWEPEKEDLEKEDMEGLLKEAKKFMKRKK
What is the function of this protein?
Histone chaperone involved in single-strand and double-strand DNA break repair.  Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (By similarity).  Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (By similarity).  Also has a nuclease activity: displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro.  Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (By similarity).  Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ).  Also acts as a negative regulator of cell pluripotency by promoting histone exchange.  Required for the embryo implantation during the epithelial to mesenchymal transition in females (By similarity).
What are the official names of this protein?
Aprataxin and PNK-like factor, Apurinic-apyrimidinic endonuclease APLF.
What is the protein family that this protein belongs to?
Belongs to the APLF family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.
Protein: LIPA_VIBCM
Sequence: MSKPIQMERGVKYRDADKMALIPIKNMPTEQKEVLRKPEWMKIKLPADSQRIQDIKAAMRKNNLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPNAPEAEEPKKLAQTIHDMKLKYVVITSVDRDDLRDGGAQHFADCNREIRALNPHIKIETLVPDFRGRMEVALEALKDNPPDVFNHNLETAPRLYRKVRPGANYKWSLELLRQFKEQHPHVPTKSGLMMGLGETKEEIVEVLKDLRAHGVTMLTLGQYLAPSRHHLPVERYVPPAEFDELKEIALELGFTHAACGPFVRSSYHADLQAKGLEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLI_MYCTU
Sequence: MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPDTQLVTIIVSWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLPGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQRAAMLGGDLAAAAAAGLSGAALDTFTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFHEIAVGPTDGYVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase B, LigB, Polydeoxyribonucleotide synthase [ATP].
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: NDUA5_DICDI
Sequence: MSIHLIKKSTGITGLKVEPNARHILAGLYNQLLKKLEILPPTAGYRKSAELETKFRLGVIENETDIVKIENKIYAGQIEELIVQAKNDLKVVDLVHESRAWELPDKNKPPVVIYSSK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA5 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: DPOE2_DICDI
Sequence: MDIQWKKQITKSFSLTGFSIKADAMKCIINRIKNEGYDITQLIDNLLKNLDKSQYLQTIEGCFKLIDTINSSDAIEKEALKVIDAFNTPLFNFDSNSKQFIKSENFDRSLHGSSNSKSDLYRKRYLKVLQRTERNDYFSTPVLASDKLKNEYQTITPLSSLLGNTGRKHVLGTISQIEEDQFYIEDLNTNVKIDISKAKFEFGIVTINSIIQASGEFIDGVFIADKIQLPPTEERCETLKFLQNIDMFGERPQKKTMEQLIKYEKEKEDNSILFLSDVWLDSERVMERLDYLFGGYKDCPPFAMILMGNFTEHPLINGTQYQLKKYFNQLAMVIQKYPNIHQFTQFIFVPGPTDPTGSLLNILPKFPISNVFIKDFISLIPKSTFTTNPCRIRYCSQEIIIFRDDLTNKMRRHCILEPSQSCDISQHLIELICSNSHLCNLTLEDKPIYWNYDHAMSVYPLPDLLVIGDKSNQYEHSRADGTYSMNPSSFSTDYSFAHYIPANKQFYYNKADRPSDEIEDDDDDEEVENQNENENENENENENENENENNDNDKTQQKDTQGDGDDNDDDEIMIDENEKQKSRKRNKKVVIITKEDELNKLEDDEEILNSLDVQQQSENHADNNNNNINNNNNDDDNEDDEDSNYNNIESEVQEVEKEEEEDEEPIDNDKLDEFIE
What is the function of this protein?
Accessory component of the DNA polymerase epsilon complex (By similarity).  Participates in DNA repair and in chromosomal DNA replication (By similarity).
What are the official names of this protein?
DNA polymerase epsilon subunit 2, DNA polymerase II subunit 2, DNA polymerase epsilon subunit B.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase epsilon subunit B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS13_CUPPJ
Sequence: MARIAGVNIPNHKHTEIGLTAIYGVGRSRARKICEATGVPFDKKVKDLTDADLEKLRDEVGKVTVEGDLRRETTMNIKRLMDLGCYRGMRHRKGLPLRGQRTRTNARTRKGPRKAGVALKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SOST_BOVIN
Sequence: MQLSLALCLVCLLVHAAFRVVEGQGWQAFKNDATEIIPELGEYPEPLPELNNKTMNRAENGGRPPHHPFETKDASEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGAAPRARKVRLVASCKCKRLTRFHNQSELKDFGPEAARPQTGRKLRPRARGTKASRAELENAY
What is the function of this protein?
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
What are the official names of this protein?
Sclerostin.
What is the protein family that this protein belongs to?
Belongs to the sclerostin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: CDC12_YEAST
Sequence: MSAATATAAPVPPPVGISNLPNQRYKIVNEEGGTFTVMLCGESGLGKTTFINTLFQTVLKRADGQQHRQEPIRKTVEIDITRALLEEKHFELRVNVIDTPGFGDNVNNNKAWQPLVDFIDDQHDSYMRQEQQPYRTKKFDLRVHAVLYFIRPTGHGLKPIDIETMKRLSTRANLIPVIAKADTLTAQELQQFKSRIRQVIEAQEIRIFTPPLDADSKEDAKSGSNPDSAAVEHARQLIEAMPFAIVGSEKKFDNGQGTQVVARKYPWGLVEIENDSHCDFRKLRALLLRTYLLDLISTTQEMHYETYRRLRLEGHENTGEGNEDFTLPAIAPARKLSHNPRYKEEENALKKYFTDQVKAEEQRFRQWEQNIVNERIRLNGDLEEIQGKVKKLEEQVKSLQVKKSHLK
What is the function of this protein?
Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring approximate 15 minutes before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck.  This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck.  The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle.  Many proteins bind asymmetrically to the septin collar.  The septin assembly is regulated by protein kinases GIN4 and/or CLA4.  May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage.  Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation.
What are the official names of this protein?
Cell division control protein 12, Septin.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Bud neck. Note=Present at the bud neck during cell division. Probably interacts with phosphoinosides such as phosphatidylinositol 4-phosphate or phosphatidylinositol 5-phosphate.
Protein: CSPL5_PICSI
Sequence: MESRTKLDYSETARSYTENKSGGNDAQRINGVYSSSFFVVDFSLRLLVIGSTFTAAIVMGTNKQTAILPIVGPLSAKYQYSPAFVFFVIANAVACGYTLLSLIFSITGKFTSTPLSVFLLSVTDLVMVALVSAGVSAAAAIAYVGYKGNSHTQWGKVCGIYDRFCHHGAGAIVASFVSLIIFMVLTVMSTYSFYRRTSSAR
What are the official names of this protein?
CASP-like protein 1U1, PsCASPL1U1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YPEL3_BOVIN
Sequence: MVRISKPKTFQAYLDDCHRRYSCAHCRAHLANHDDLISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIHCENCKTTLGWKYEQAFESSQKYKEGKYIIELNHMIKDNGWD
What is the function of this protein?
Involved in proliferation and apoptosis in myeloid precursor cells.
What are the official names of this protein?
Protein yippee-like 3.
What is the protein family that this protein belongs to?
Belongs to the yippee family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.