PharMolix/UniProtQA huggingface dataset:
Protein: LRA25_RAT
Sequence: MNGLPSTEAPGGAGCALAGLPPLPRGLSGLLNASGGSWRELERVYSQRSRIHDELSRAARAPDGPRHAAGSANLGSAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSLCQDLSSSLHSDSSYPPDAGLSDDDEPPDASLPPDPPPLTVPQTHNARDQWLQDAFQISL
What is the function of this protein?
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta.  Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia.  LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
What are the official names of this protein?
Leucine repeat adapter protein 25, Mammary tumor virus receptor 2.
What is the protein family that this protein belongs to?
Belongs to the FAM89 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, lamellipodium. Note=Co- localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium.
Protein: MURD_STRP7
Sequence: MKVIDQFKNKKVLVLGLAKSGESAARLLDKLGAIVTVNDGKPFEDNPAAQSLLEEGIKVITGGHPLELLDEEFALMVKNPGIPYNNPMIEKALAKGIPVLTEVELAYLISEAPIIGITGSNGKTTTTTMIGEVLTAAGQHGLLSGNIGYPASQVAQIASDKDTLVMELSSFQLMGVQEFHPEIAVITNLMPTHIDYHGSFSEYVAAKWNIQNKMTAADFLVLNFNQDLAKDLTSKTEATVVPFSTLEKVDGAYLEDGQLYFRGEVVMAANEIGVPGSHNVENALATIAVAKLRGVDNQTIKETLSAFGGVKHRLQFVDDIKGVKFYNDSKSTNILATQKALSGFDNSKVVLIAGGLDRGNEFDELVPDITGLKKMVILGQSAERVKRAADKAGVAYVEATDIADATRKAYELATQGDVVLLSPANASWDMYANFEVRGDLFIDTVAELKE
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_CHLTE
Sequence: MSDTAAAPDKTAKSALAEKLATLPTSPGVYRFSNAAGTVIYVGKARNLRNRVRSYFNSQGRQPGKTAVMVSHIADLNVIITSSEVEALILENNLIKELKPRYNVNLKDDKSYPWLVITNERFPRIFLTRQVRRDGSLYFGPYTEASQLRLILDLIGSIFPVRSCKYKLTEEAVASGRYRVCLDYHIHKCKGPCEGLQSEEEYQAMIREIVTLLKGKTSALLRDLSAEMQKKAKELKFEEAAALKAQIEGLKRYAERQKIVSTEAIDRDVFAVAAGEDDACGVVFRIREGKLIGSRHTYLSNTGNTPLPNLLASFVEHYYLETPDLIPQELMLQAELPEEELEALRQLLSSRQTERRQVRFTVPRIGEKAHLIAMCLDNAKHHLHEFMVQKKLRGEIARKSPALESLKQVLHLGKLPERIECFDNSHFQGTDYVSSMVTFVSGKPKKSDYRKFRLKSFEGSDDYAAMREAVTRRYGGSLAGELPLPDLVLIDGGKGQVNVAWQVLQELGLDLPVAGLAKRLEEIYVPNEPDPYNLPKTSPALKLLQQLRDEAHRFAITYHRKLRSDRTIRTELTGIKGVGEKSAEKLLKHFGSVESVSKASIDELSAVAGRKTAESIYRYFNAGDAP
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_STRT1
Sequence: MLFDQIARNKRKTWLLLLVFFLLLGLVGYGVGYLWLGSGFGGMILALVIGFIYAVTMIFQSTNVVMAMNGAREVDEQTAPNLYHVVEDMAMVAQIPMPRVFIVDDPSMNAFATGSSPKNAAVAATTGLLAVMNREELEGVIGHEVSHIRNYDIRISTIAVALASAITMLAVMARNMMFWGGGRRRNDDDRNGSSGLEIILLIISLIAIILAPLAATLVQLAISRQREFLADASSVELTRNPQGMINALLKLDNSAPMQHHVDDASAALFINDPKKESGLQKLFYTHPPISERVERLKQM
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PYRC_METST
Sequence: MSNLVLKNCKTIDNKIVNIIIENGIIKDIKKTILPSEKETDTICDIKENIIIPGLIDTHVHLRDPGMTQKETWTTGTQAAAHGGYTTIIDMPNTLPATDTKKAFQEKRNIATKKSYVDFGLHAGVKTRQDVMDIMSEKPASYKIFMDLYTNKQLDEMFNYVSQTNKPLSLHCEDKTLVDYNIKTMKKNPLNKNKTITYSYARSALAELIAVNRAIEFAKKYKLQLHLCHISTRQTLELIHEAKEKLNISIEATPHHIFLDNTTYERYGVKAKTNPPLRDSNYNITIDNLNEFDSIGTDHAPHTIEEKEKDTWKSAAGIPGLETALKLLLTEVNNKRLTLEQLVKLTSTNPANIFNIPNKGKIKKGYDADITVINMKETGKISIENTYTKAKYTPFENRDYVGSNIMTINRGNIISQDNDVYKYDSKYIY
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: SECE_TREPA
Sequence: MLKFAKFRRECVAEFRRVVWPARTQVHTAVKVVLVSTVVMALFLGLIDALFVALLSFFF
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: BIOF2_POLSJ
Sequence: MLIDHLNRQQLEREAQGLQRQRRIAESPCAPRQWVSQDGQPAREMLAFCSNDYLGLANHPALVEALAEGARQFGAGSGASHLISGHSRAHAALEGDLAAWLAPSIPNAAALYFCTGYLANLALLTALGDASATIFADKLNHASLIDGALLAKATMQRYAHRNLTVLASQLESCTTPIKLIVTDAVFSMDGDLADLPALLALAERFDAWLIVDDAHGFGVLGDQGRGSLSHFGLRSERLIYMGTLGKAAGLGGAFVAAHPSIIDWLVQAARPYIYTTAAPPAVAHALRESLRLISSAEGEQRRAHLQQLIIQLRTQLSALIGAHPTLGWRLADSSTAIQPLIVGDNAAALALMAALDAQGLWVPAIRPPTVPVGTARLRITLSATHSAADVQRLVDGLACAARELP
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase 2, AONS 2, 7-keto-8-amino-pelargonic acid synthase 2, 7-KAP synthase 2, KAPA synthase 2, 8-amino-7-ketopelargonate synthase 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: MDM12_NEUCR
Sequence: MSIDLNWDTVTGGPDGQELAQKIRDFIHEKFQAVPLPRFIKSVTVHDFEFGSIPPEIELKDITDPLPDFYEEQPGIDSSEESDSEEEVAYENEGEYLDDPVEQQYGRLRGASASESRRRLTVNSSTGSRNGSGPNSGRVAYLPPHLNPHYNGGSGNNSSPSLDRDGRYYRDPNTAGLGGPAHGTNHHHADLGSPFLGVSTPGIPGGTSNLNLHYFTSQFTAGLSGTQTPLAAVAGAAHQRGPSWIADQQQQQQQQNNMLPGGAGGGGAGGGGMGGPVAAAAAAAAATNQGLHSSSTPHLRLHFPGVGTGKPTPGPSPLTGTSTPLGTLGTAGGVGGIGRGMGMAGMGSMASMGYPPTAPVLAIPTGPRHKRNPSSQSLNSVGDYSPVAPAPAERQGLFSAAAATSPPSSTPSPAVGLGIGGRGIGAAGAGAGALATSGPRLQIPKQGLREKHSVSTLAPNSAGTSNNRAGSAILDDDDGFLDGMHDHRDHPAQQQLEPEEDEEEEEEGEEERQRFREPRVEDIQAVFRIKYAGDVKLLLTADILLDYPMPSFVGIPVRLSITGLTFDGVGVVANIRKRVHFCFLSPEDAVAAVGGEENKAAGSGNGSGIGGGSDGAKTKMGGLLQEIRVESEIGQRESGKQSLKNVGKVERFVLEQVRRIFEEEFVYPSFWTFLV
What is the function of this protein?
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria.  Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria.  Mdm12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.  The mdm12-mmm-1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex.  The mdm10-mdm12-mmm-1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex.  Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
What are the official names of this protein?
Mitochondrial distribution and morphology protein 12, Mitochondrial inheritance component mdm-12.
What is the protein family that this protein belongs to?
Belongs to the MDM12 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Protein: NS1_ORSVW
Sequence: MGSETLSVIQVRLQNIYDNDKVALLKITCNTNRLILLTHTLAKSVIHTIKLNGTVFLHIVTSSDFCPTSDIIESANFTTMPVLQNGGYIWELIELTHCFQTNGLIDDNCEVTFSKRLSDSELEKYSSQLSDLLGLN
What is the function of this protein?
Plays a major role in antagonizing the type I IFN-mediated antiviral response by degrading or inhibiting multiple cellular factors required for either IFN induction or response pathways.  Acts cooperatively with NS2 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3.  Also disrupts the association of IRF3 with CREBBP.  Interacts with host mitochondrial-associated membrane (MAM) MAVS and prevents the interaction with RIGI.  Interacts with TRIM25 to suppress TRIM25-mediated RIGI ubiquitination and thereby RIGI-MAVS interaction.  Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C.  The degradasome requires an intact mitochondrial MAVS.  Decreases the levels of host TRAF3 and IKBKE/IKK-epsilon.  As functions other than disruptions of the type I IFN-mediated antiviral signaling pathways, induces host SOCS1 and SOCS3 expression.  Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism and thus facilitates virus growth.  Additionally, NS1 may serve some inhibitory role in viral transcription and RNA replication.  Suppresses proliferation and activation of host CD103+ CD8+ cytotoxic T-lymphocytes and Th17 helper T-lymphocytes.
What are the official names of this protein?
Non-structural protein 1, Non-structural protein 1C.
What is the protein family that this protein belongs to?
Belongs to the pneumovirus non-structural protein 1 family.
What are the subcellular locations of this protein?
Host cytoplasm. Host mitochondrion. Host nucleus. Note=Most NS1 resides in the mitochondria as a heteromer with NS2.
Protein: GAG_SIVGB
Sequence: MGNGNSALLGTDLDKFEKIRLKRGGKKCYRLKHLCWCKGELDRFGLSDKLLETQQGCEKILSVCWPLYDQGSDNLKALVGTVCVVACIHAGIEIKSTQDALKKLKVITRKEEKQEDESKNFPVQRDAAGQYQYTPISPRIIQTWVKTVEEKKWKPEVIPLFSALTEGAISHDLNIMLNAVGDHQGAMQVLKDVINEQAAEWDLTHPQQQPAQPGGGLRTPSGSDIAGTTSTVEEQLAWMNMQQNAINVGTIYKSWIILGMNRLVKSHCPISITDVRQGPKEAFKDYVDRFYNVMRAEQASGEVKMWMQQHLLIENANPECKQILRSLGKGATLEEMLEACQGVGGPQHKARLMAEMMRTVVGQSQNFVQQRGPQRGPVRQPTGRKPICFNCNKEGHVARFFKAPRRKGCWNCGAMDHQKAQCPKPAQQQRVNFLGYGPWGPSKPGNYPAQEVTPTAPPLEEKPLQKTLSTYQKLGRGLRQKMKEEKREEDFHSLSTLFQEDQ
What is the function of this protein?
p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
What are the official names of this protein?
Gag polyprotein, Pr55Gag.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group gag polyprotein family.
What are the subcellular locations of this protein?
[Matrix protein p17]: Virion. Host nucleus. Host cytoplasm. Host cell membrane; Lipid-anchor. Note=Following virus entry, the nuclear localization signal (NLS) of the matrix protein participates with Vpr to the nuclear localization of the viral genome. During virus production, the nuclear export activity of the matrix protein counteracts the NLS to maintain the Gag and Gag-Pol polyproteins in the cytoplasm, thereby directing unspliced RNA to the plasma membrane (By similarity). SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p7]: Virion.
Protein: WAKLS_ARATH
Sequence: MKLQHVVYLVAIFFVVAIFVIACIEENKYLVWIMIILANTTNILSLVRSISYIKNIRKHQKDTKIQRQLFFEKNGGGMLIERLSGAGSSNIDFKIFTEEDMKEATNGYDVSRILGQGGQWTVYKGILPDNSIVAIKKTRLGDNNQVEQFINEVLVLSQINHRNVVKLLGCCLETEVPLLVYEFITGGSLFDHLHGSMFVSSLTWEHRLEIAIEVAGAIAYLHSGASIPIIHRDIKTENILLDENLTAKVADFGASKLKPMDKEQLTTMVQGTLGYLDPEYYTTWLLNEKSDVYSFGVVLMELISGQKALCFERPETSKHLVSYFVLATKENRLHEIIDDQVLNEENQREIHEAARVAVECTRLKGEERPRMIEVAAELETLRAKTTKHNWLDQYPEENVHLLGSNIVSAQGHTSSRGYDNNKNVARFDIEAGR
What is the function of this protein?
Putative serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component.
What are the official names of this protein?
Putative wall-associated receptor kinase-like 16.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL28_CHRVO
Sequence: MARVCKVTGKRPMTGNNVSHANNKTKRRFLPNLQYRKFWVESENRWVRLRVSNAALRTIDKVGIDVVLADLRARGEI
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: SYA_NITMU
Sequence: MKSSEVRQKFLEFFETHGHTIVPSSPLVPGNDPTLLFTNAGMVQFKDVFLGQDKRPYVRAASAQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRNAIRFAWEFLTDILKIPRERLWITVYAEDDEAADIWLNEVGIDSSRFTRIATQDNFWQMGDTGPCGPCSEIFYDHGPEIPGGPPGTPNADGDRYVEIWNLVFMQYNRDSAGTLHPLPRPSVDTGMGLERISAVMQQVHSNYEIDLFQQLIKAAARATNTTDLSSSSLNVIADHIRACSFLIADGVIPGNEGRGYVLRRIIRRAIRHGYKLGQKQPFFHQLVEDLASVMGQAYPELMEAKTRVSAVLKQEEERFAETLENGMQVLEAALRRGDRMLDGETLFRLYDTFGFPLDLTADIARERGIAIDEAGFDQAMEQQRERARTTSKFIMQEAIAYSGPSTTFHGYESLRQEGQVLAIYKEGSRVEFIEAGDEAVIVLDKTPFYAESGGQVGDSGELLAANGTFAVADTQKIQADVFGHKGLLRSGRLATGDAVLAEVDRAARARTERNHSVTHLMHKALREVLGHHVQQKGSLVDANKTRFDFAHNQPVTDAEIRKVEMLVNAEILANAATEARMMAIEDAKKSGAMMLFGEKYSDEVRVLDIGTSRELCGGTHVKRTGDIGLFKIVAESGVAAGVRRVEAVTGERALTYIQEQELQLQRVAAAVKAQPQDAAARITQILDNVKHLERELGRMKSKLASSQGDDFADRVREIKGVKVLAVCLEEADPKTLREAVDKFKNKFKSCVTVLAAVEDGKVKLIAGVTSDLTARLKAGDLVNFVAQQVGGKGGGRADLAQAGGTVPDSLPAALESVASWVEQHL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U652_DICDI
Sequence: MSKQNKLTKVLDNDLDDIDIEEDDSTNRKFESMSEDEETPGMCCECTDQPAEVVCLQCQDELCTVCSTSLHRRGSRRSHIFKNKHGQELDYDELNKRDRQPPLHGKEDEKVQNNNNNNNNTNNTNNIEMDDNKSINNNNNNINSINSMYRGTSNLLNPLPFHHTNQQRNGGGSNNHQINNHHKDEDEEIDEDEEKFIHKNENFTDFIPRLSKDWFTERSKYIPIRLNIRERNDLRLLEAALHVSEYTDKIDIIHVGGSKSKRINDQLRGMCAILSGLLVASDFKKGQQLVENKDFFENEEFFQNVFEIGRRHKIMNPAKMRTEYGKMIHLLQDAADEDVKKNLSGLNMIKPLKTVFLFLDERNGLKLLEDPLLELATREVLAENKTRPQIQREIREKEHAIKTLSRRYSSSMLKSEEIEVCIYSICDNHTFLRENRDPVKKMKHLLKEYFSPNQSERGFSLALEHGIGGARLSHNHRKQYNYVYQSLSLWQHILHDMFKLWYFAEIDLLCGHRYQLSNTGQGLNRIQQCPNVGKIMHSILRQTQKKVGDDWVGSSVIHLGDHNVPNSLVFIDKYTQISRILSPIVLTIEYIPKITDPNLVAYIKNTFGGPQTLTKIILCDFFKHAFDGSGADNFFDAGSCIDGRLTSAWQWSAQIAKKPYYPIFLLSGFSGFDGSFN
What are the official names of this protein?
UPF0652 protein.
What is the protein family that this protein belongs to?
Belongs to the UPF0652 family.
Protein: MURG_POLAQ
Sequence: MTKPSILVMAGGTGGHIFPGLAVAEYLRICGWNVSWLGNQSGMEYRLVKSCNFPFEAVEFGGLRGKGIKAKLMLPINLARACHQSWKIMRRLKPNVVLGMGGYITFPGGLISKLLKRPLVLHEANSVAGSANRALAKIAMRTLTGFPNTMENAEWVGNPIRQEFDDIAAPAERYEQRQGPLSLLVVGGSLGAAALNENIPAALALIPLEQRPTVIHQAGDKHLLDLQKRYADLGVLADIRPFIEDMPTAYAQADLVICRSGAMTVSELAACGVASCLIPFPHAIDDHQTANAQFLSDADAAVFLPQKNLNPQDLALMIQNLTRTDLKEMAVRAHALSKPHATQRVAEVCADCAGVGI
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HIS6_KLEP3
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYADEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAQILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWFDAETGKYHVNQYTGDETRTRVTQWETLDWVEEVQKRGAGEIVLNMMNQDGVRNGYDLQQLAKVRAVCHVPLIASGGAGTMEHFLEAFRDANVDGALAASVFHKQIINIGELKAYLAAQGVEIRVC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MOAC_ROSS1
Sequence: MSDLTHLDESGRARMVDVGAKDDTLREAVARGEVRMRPETLQRLAAGDMPKGDVLATARIAGIMAAKRAPDLIPLCHPLLLTHVAVDARLDVATSTVQIEATVRTVGKTGVEMEALTAVSVAALTIYDMCKAIDREMQIGAIRLVRKSGGRSGDFVND
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: YFKH_BACSU
Sequence: MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAYLPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAIVRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGASDLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLFSFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH
What are the official names of this protein?
Putative ribonuclease-like protein YfkH.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MATK_AMPBR
Sequence: MEEYRAYLELHRSRHQDTLYPLFFREYIYGLACGHGSILVESVGYNNKFSLLIVKRLITRMYQQTHFIIFANDSNKNPFRGYNNHFYSQIILEGFVVVVEIRFSLQLFISSLRELEIIKSYNNLRSIHSIFPFFEDKLIYLNLESDIRIPYPIHLEILVQILRYWIKDVSFFHLLRLFFSYYYNRNNLFTPKKWISTFFSKSNPSFFLFLYNLYVQEYESIFIFLRNKSSQLRLKYFRVFFERIFFYEKIEHLVEVSVKDCSYTFSFFKDTFIHYVRYQGKSILVSKNTPLFINKWKYYFIYLWQCHFDIWSRPGTIHINQLSRHSFHFLGYFLSIRLNFSVVRSQMLQNSFLIKIVMKKLDTIVPIISLIRSLAKAKFCNVFGHPISKPVWANLSDFDIIDRFLRICRNFYHYYNGSAKKKSLYQIRYILRLSCIKTLARKHKSTARTFLKRLGSEKLLEEFFTEEEDIFSLIFPIPKTSFTVQRLYRGRIWYLDILFRNDFVNHL
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: KCC2B_HUMAN
Sequence: MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle (PubMed:16690701).  In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.  This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.  In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling.  Also regulates the migration of developing neurons (PubMed:29100089).  Participates in the modulation of skeletal muscle function in response to exercise (PubMed:16690701).  In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.  In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).  Phosphorylates reticulophagy regulator RETREG1 at 'Ser-151' under endoplasmic reticulum stress conditions which enhances RETREG1 oligomerization and its membrane scission and reticulophagy activity (PubMed:31930741).
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type II subunit beta, CaM kinase II subunit beta, CaMK-II subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Synapse. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.
Protein: TI17D_DROME
Sequence: MEYNRQPCPIRIVEDCGCAFMMGTMGGSLFQYLKGFRNAPSGLRRGLHGGIESVRLRTPAIAGSFAIWGATFSTVDCVMVSYRQREDSWNAIVSGAATGGILAARNGIRAMANSAFVGCLVLAMLEGAGAAVATIYASDGGVKAEESLITVDQQMQRPQWETSVADSNLTGAELERVLDECRAYRAHNKMQQPMRSDAVEGKELGQLMKPMHSLVDLVKLAEIV
What is the function of this protein?
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
What are the official names of this protein?
Probable mitochondrial import inner membrane translocase subunit Tim17 4.
What is the protein family that this protein belongs to?
Belongs to the Tim17/Tim22/Tim23 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BIOD_NEIG2
Sequence: MKGVYFVSGIDTDIGKTVATGMLAKQLLQQGKSVITQKPVQTGCQDIAEDIAVHRKIMGIPMQEADEQRLTMPEIFSHPASPHLAARLDGRGLDLDKIRTATQELAAQYEVVLVEGAGGLMVPLTEKLLTIDHIQQQAYPVILVTSGRLGSINHTLLSFVVLKQYGIRLHSLVFNHIHDSRDAHVAQDSLNYLQCRLKADFPEAEWMELAKTGAV
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.