PharMolix/UniProtQA huggingface dataset:
Protein: CNG17_ARATH
Sequence: MELRKDKLLMFYSEGKESKEAKWAVNDPMSKSYKLSLPSALRPDNLLPGNRLRYTDASKSKSSKVSWYKTILDPGSEIVLKWNWVFIVSCMVALFIDPLYFFVPAIGGDKNYPCARTDTSLSILVTFFRTIADLFYLLHIFIKFRTGFIAPNSSTRVFGRGELVMDPKAIAWRYIKSDFIIDLIATLPLPQIVIWFVISTTKSYRFDHNNNAIALIVLLQYIPRFYLIIPLSSQIVKATGVVTKTAWAGAAYNLLLYMLASHVLGAAWYILSVDRYTSCWKSRCNGEAGQVNCQLYYLDCDSMYDNNQMTWANVTKVFKLCDARNGEFKYGIFGNAITKNVVSSQFFERYFYCLWWGLQQLSSYGQNLSTTMFMGETTFAVLIAIFGLVLFAHLIGNMQTYLQSLTVRLEEWRLKKRDTEEWMRHRQLPEELRNRVRRYEQYKWLATRGVDEEVLLQSLPTDLRRDIQRHLCLDLVRRVPFFSQMDDQLLDAICERLVSSLCTEGTYLVREGDLISEMLFIIRGRLESSTTNGGRTGFFNSIILRPGDFCGEELLSWALLPKSTLNLPSSTRTVRALVEVEAFALRAEDLKFVANQFRRLHSKKLQHTFRFYSHHWRTWAACFIQAAWRRYKRRVMENNLTAIESMENEEGEVGEELVVVEEEECVEESPRTKMNLGVMVLASRFAANTRRGVAAQRVKDVELPRFKKPEEPDFSAEHDD
What is the function of this protein?
Probable cyclic nucleotide-gated ion channel (PubMed:11500563).  Forms a functional cation-translocating unit with AHAs that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes (PubMed:26071421).  Required for PSK-induced protoplast expansion (PubMed:26071421).
What are the official names of this protein?
Cyclic nucleotide-gated ion channel 17, Cyclic nucleotide- and calmodulin-regulated ion channel 17.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SMAD1_BOVIN
Sequence: MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPSLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
What is the function of this protein?
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase.  SMAD1 is a receptor-regulated SMAD (R-SMAD).  May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
What are the official names of this protein?
Mothers against decapentaplegic homolog 1, MAD homolog 1, Mothers against DPP homolog 1, SMAD family member 1, SMAD 1, Smad1.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Colocalizes with LEMD3 at the nucleus inner membrane (By similarity). Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (By similarity). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity).
Protein: SSPF_BACCE
Sequence: MSRRRGVMSNQFKEELAKELGFYDVVQKEGWGGIRAKDAGNMVKRAIEIAEQQLMKRNQ
What is the function of this protein?
May play some important role in either sporulation or the dormant spore.
What are the official names of this protein?
Protein SspF.
What is the protein family that this protein belongs to?
Belongs to the alpha/beta-type SASP family.
Protein: RSMH_OCEIH
Sequence: MFEHYSVLKEESIKGLAIKPDGIYVDCTTGGGGHSLEIASRLNENGQLFAFDQDKDALAAARDRLSTYADRIVFVQSNFRGLEEQLKKHGIEQVDGILFDLGVSSPQLDRGDRGFSYNHDALLDMRMDQSQHLSAYEVVNEWSYERLVSIFFSYGEEKFSKQIARKIEAYREQQDIKTTHQLVEIIKDAIPAPARRKGGHPAKRIFQALRIAVNDELEVFNNALHQAARLIAVNGRIAVITFHSLEDRICKQAFKKWSTDKPTPRHLPIVPESHQAPFKLVTRKPITADTSELDENRRSRSAKLRVIEKVSEWDHEFTYEEGWRK
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARMX5_PONAB
Sequence: MVDSGTEARARGKAEAGLQDGISGPAAARVNGKTQAKAVAEAELKTESVTQAKAGDGAMTRTHTVTYREAMAVTREVIKVEDTTKTRVMVQTKTKPLAERSIVPQTKSRAMPISRVSTVTKSEVKVVAVIEANIKSYAKSHDKANTGSRPDRREEASIGMKSSDEDEENICSWFWTGEEPSVGSWFWPEEETSLQVYKPLPKIQEKPKPTHKPTLTIKQTVIAWSRARYIVLVPVEGGEQSFPPEGNWTLVETLIETPLGIRPLTKIPPYHGPYYQTLAEIKKQIRQREKYGPNPKACHCKSRGFSLEPKEFDKLVALLKLTKDPFIHEIATMIMGISPAYPFTQDIIHDVGITVMIENLVSNPNVKEHPRALSMVDDSSESSEGPKSGESYIHQVCKGILSCPMNSPVQLAGLKLLGHLSVKFEDHYVITSYIPDFLTLLNKGSVKTKFYVLKVFSCLSKNHANTRELISAKVLSSLVAPFNKNESKANILNIIEIFENINFQVKTKAKLFTKEKFTKSELISIFQEAKQFGQKLQDLAEHSDPEVRDKVIRLILKL
What are the official names of this protein?
Armadillo repeat-containing X-linked protein 5.
What is the protein family that this protein belongs to?
Belongs to the eutherian X-chromosome-specific Armcx family.
Protein: RBS_TOBAC
Sequence: MASSVLSSAAVATRSNVAQANMVAPFTGLKSAASFPVSRKQNLDITSIASNGGRVQCMQVWPPINKKKYETLSYLPDLSQEQLLSEVEYLLKNGWVPCLEFETEHGFVYRENNKSPGYYDGRYWTMWKLPMFGCTDATQVLAEVEEAKKAYPQAWIRIIGFDNVRQVQCISFIAYKPEGY
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate (PubMed:3681999).  Both reactions occur simultaneously and in competition at the same active site (Probable).  Involved in antiviral defenses (By similarity).
What are the official names of this protein?
Ribulose bisphosphate carboxylase small subunit, chloroplastic, RuBisCO small subunit, TSSU3-8.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO small chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast. SUBCELLULAR LOCATION: Cell junction, plasmodesma. Note=(Microbial infection) May be present in virus replication complexes (VRCs) of tobamovirus infected cells.
Protein: ZAPA_ALKCK
Sequence: MEKNNNKKRATVRIQGQTYKVVSSEEPAHVKEVASYMNKKMEELKKRNPYLDSTKLAVLTALNIADEYLKLKRQYEGE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division (By similarity).
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid- cell. In sporulating cells, localizes near the cell poles (By similarity).
Protein: PETG_SOYBN
Sequence: MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DNAG_GEOSE
Sequence: MGHRIPEETIEAIRRGVDIVDVIGEYVQLKRQGRNYFGLCPFHGEKTPSFSVSPEKQIFHCFGCGAGGNAFTFLMDIEGIPFVEAAKRLAAKAGVDLSVYELDVRGRDDGQTDEAKAMTEAHALLKRFYHHLLVHTKEGQAALDYLQARGWTKETIDRFEIGYAPDAPDAAAKLLESHSFSLPVMEKAGLLTKKEDGRYVGRFRNRIMFPIHDHRGETVGFSGRLLGEGHPKYVNSPETPVFRKGAILYHFHAARVPIRKRQEALLVEGFADVISAAQAGIDYAIATMGTSLTEEQARILRPCDTITICYDGDRAGIEAAWAAAEQLSALGCRVKVASLPNGLDPDEYIRVYGGERFAGEAGCRRPLVAFKMAYLRRGKNLQHEGERLRYIDEALREIGKLSSPVEQDYYLRQLAEEFSLSLSALHEQLSRSQRERTKPREAPDGETARPMLAKKLLPAFQNAERLLLAHMMRSRDVALVVQERIGGRFNIEEHRALAAYIYAFYEEGHEADPGALISRIPGELQPLASDVSLLLIADDVSEQELEDYIRHVLNRPKWLMLKVKEQEKTEAERRKDFLTAARIAKEMIEMKKMLSSS
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase.
What is the protein family that this protein belongs to?
Belongs to the DnaG primase family.
Protein: YDGG_BACSU
Sequence: MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLLKILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITPSGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator YdgG.
Protein: Y7710_HAEIG
Sequence: MAQHSKYSDAQLSAIVNDMIAVLEKHKAPVDLLLIALGNMASNLLTTSVPQTQREALAQAFSNSLINAVKTR
What are the official names of this protein?
UPF0352 protein CGSHiGG_07710.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: HMDH_BORBU
Sequence: MNLESLSSFMELSKNFRHKSVLEKRQEIKSFLELSYKDFFYNNANEDFLFNMIENYIGYLSFPIGIVKNLKINGKYYSLPIATEESSVVAALNFAAKILENADLRYSLGEVLGISQIYIKSEKDLSKIFVDLGDKIKTWIEPLLTNMNQRGGGFRRLSTRHIKELGIQKLNIYVDTCDAMGANLLNSIAERVAEFIFLEFGYECVLKVLSNDISEFTAKARFVLDFKHLLPGKEDSWNLAKKIELISSIGFYEEERAVTNNKGIMNGITGVCLATFNDTRALEASVHKFASKSGKYFPLSKFYTTDNALVGEIEIPLQVGTKGGVISFNEASILSFKIMNVNSKSEFIGILSCVGLASNFAALRALAFNGIQKGHMRLHVNKILHLLKTKYNISDFEKDKLLLEMERMNIYSFDFAFKILKKIRLENENKV
What is the function of this protein?
Converts HMG-CoA to mevalonate.
What are the official names of this protein?
Probable 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
Protein: GID4_MOUSE
Sequence: MPVRTECPPPAGASTTSAASLIPPPPINTQQPGVATSLLYSGSKFRGHQKSKGNSYDVEVVLQHVDTGNSYLCGYLKIKGLTEEYPTLTTFFEGEIISKKHPFLTRKWDADEDVDRKHWGKFLAFYQYAKSFNSDDFDYEELKNGDYVFMRWKEQFLVPDHTIKDISGASFAGFYYICFQKSAASIEGYYYHRSSEWYQSLNLTHVPEHSAPIYEFR
What is the function of this protein?
Substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1.  Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly-Leu-Trp.  Binds peptides with an N-terminal sequence of the type Pro-[Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr].  Does not bind peptides with an acetylated N-terminal Pro residue.
What are the official names of this protein?
Glucose-induced degradation protein 4 homolog, Vacuolar import and degradation protein 24 homolog.
What is the protein family that this protein belongs to?
Belongs to the GID4/VID24 family.
Protein: CYB_MACLA
Sequence: MTNLRKTHPLMKIINHAFIDLPAPSNISAWWNFGSLLGICLIIQMLTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNMHANGASMFFMCLFIHVGRGIYYGSYMYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIVTALVIVHLLFLHETGSNNPTGLNPDSDKIPFHPYYTIKDTLGFIMMILALLLLTMFSPDMLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIIPLLHTSKQRSLMFRPISQTLFWLLTSDLLILTWIGGQPVEQPFIIIGQIASITYFLIIIAFMPMAGLFENYMLKPKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DCUP_COXB2
Sequence: MLRLKNDRFIRALLRQPVDRTPVWIMRQAGRYLPEYRQLREKVPNFMAFCKTPELACEATLQPLRRFPLDAAIIFSDILTIPDAMGVDLHIAPTVGPVIRNPVRSAQDVNRLQMPPVEEALSYLFDAIRLTVKALDHRVPLIGFAGSPWTLACYMTEGQSSKTFLTARAMLYQQPDVFHTLLQKLTTLTIAYLNAQIKAGADVVMLFDTWGGLLTPSLYRQFSLDYLSQIAAEVVRQKNGRKIPLIFFTKNGGQWLESIANSGCDAVGLDWTTDIGQARRRVGDRVALQGNLDPAILLSNPESISTAAVDILKSYGQGSGHVFNLGHGIDPSTPIENVAALVETVQNFSIKNEEPINSYYR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_WOLPM
Sequence: MKTFFLKEKQINKKWFVIDAEGLVVGRLAAFVATLLRGKHKPEYTPHMDCGDNVIIINAERVHFTGKKLKDKIYYKHTGYSGGLKKTTPDNILNGKFPERVIEMAVKRMLDDGPMARRRFENLYVYSGSEHKHQGQQPEKIDFASLNRKNKK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RS17_SYNJA
Sequence: MPAREKIGVVVSNKMQKTVVVAVENRVAHPKYGKIVVKTKKFKAHDEENRCQEGDLVRITETRPLSRTKRWRVAEIIREVKKL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ARGC_NITOC
Sequence: MIRAAIVGGTGYTGVELLRLLANHPNVEIVAITSRTEAGRPVSKLFPNLRGYLDICFTEPEPAQLAAECDVVFFATPHGVAMDMVPALLAQNTRVIDLSADFRLADPTIWEQWYGRPHAAPHLLAEAVYGLPEINREAIRQARLIACPGCYPTAVQLGFLPLLEHQLVDPSRLIADAKSGASGAGRKAALGTLLCEAGENFKAYSVSGHRHLPEIIQGLQWASRSSVDLTFVPHLIPMIRGIHATLYAQLEHEVDLQELYEQRYAPEPFVDVLPPGSHPETRSVRGNNMCRLAIHRPSAGNTVIVLSVTDNLIKGASGQAIQNMNLMFGQEETRGLMHIAVIP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAG1_DANRE
Sequence: MEKGRWSSEDAPRASMPDELSHPKFSEWKFKLFRVRSMEKAPVQNETPVEKENQPELAMEKTSSQGSVMRLCFGGKSKENVESARGRVDLKLQEIDTHMNLLKNMCRLCGIAIQKAKGPSHEVQGVLEESSRCALRRMGCKLVTWPEVILKVFKVDVTTDMETVHPSLFCHRCWTAAIRGGGFCSFTNTRIPDWKPHTSQCNLCFPKKSSFQRVGRKRTKPLKSAHILPKRFRRDSSESSRVWRQTTENPDGKEWLKLSVQRGQWVKNITRCQRDHLSTKLIPTEVPADLIRAVTCQVCDHLLSDPVQSPCRHLFCRLCIIRYTHALGPNCPTCNQHLNPSHLIKPAKFFLATLSSLPLLCPSEECSDWVRLDSFREHCLNHYREKESQEEQTPSEQNLDGYLPVNKGGRPRQHLLSLTRRAQKHRLRDLKNQVKTFAEKEEGGDVKSVCLTLFLLALRAGNEHKQADELEAMMQGRGFGLHPAVCLAIRVNTFLSCSQYHKMYRTVKATSGRQIFQPLHTLRNAEKELLPGFHQFEWQPALKNVSTSWDVGIIDGLSGWTVSVDDVPADTISRRFRYDVALVSALKDLEEDIMEGLRERALDDSMCTSGFTVVVKESCDGMGDVSEKHGSGPAVPEKAVRFSFTIMSISIRLEGEDDGITIFQEQKPNSELSCRPLCLMFVDESDHETLTAILGPVVAERKAMMESRLIISVGGLLRSFRFFFRGTGYDEKMVREMEGLEASGSTYICTLCDSTRAEASQNMVLHSITRSHDENLERYEIWRKNPFSESADELRDRVKGVSAKPFMETQPTLDALHCDIGNATEFYKIFQDEIGEVYQKPNPSREERRRWRSTLDKQLRKKMKLKPVMRMNGNYARRLMTREAVEAVCELVPSEERREALLKLMDLYLQMKPVWRSTCPSRDCPDQLCQYSYNSQQFADLLSSMFKYRYDGKITNYLHKTLAHVPEIVERDGSIGAWASEGNESGNKLFRRFRKMNARQSKTFELEDILKHHWLYTSKYLQKFMEAHKNSVKAMQATFNPEETPEEADNSLDVPDF
What is the function of this protein?
Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination.  V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments.  In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment.  RAG2 is not a catalytic component but is required for all known catalytic activities.  DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.  In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3.  Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity).
What are the official names of this protein?
V(D)J recombination-activating protein 1, RAG-1.
What is the protein family that this protein belongs to?
Belongs to the RAG1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIS14_SCHPO
Sequence: MSSHGDASVLPKIALESINDYSYVKSVFRQAIQEKLAIHLPEQASREAGMGREDQLRIRVKEMLNELIESTFSIIQENVTINGFDANSALQDPKNSDQIEPFDLALRTRVQQLFNEVEDAHVLVARYRKSVPAQYEKAYVDAMEQQTAFLRNVKDDYVSLQDKEVENPDEQTSTTVFRKEDIDRYEQTIAKVAYLKKNLPRVVARLEKTP
What is the function of this protein?
Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle.  Required for correct chromosome segregation where it has a role in the formation and/or maintenance of specialized chromatin at the centromere.
What are the official names of this protein?
Kinetochore protein mis14, NMS complex subunit mis14.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Protein: XGPT_MANSM
Sequence: MSEKYVVTWDMFHMHARKLAERLLPASQWKGIIAVSRGGLFPAAVLARELGLRHVETVCIASYDHDQQGDLKVIHKAETDGEGFIVVDDLVDTGNTAREIRNMYPKAKFVTVFAKPAGAPLVDDYVIDIPQNTWIEQPWDLGIGFVPPLARK
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GLYA_BRUA4
Sequence: MSQANAAAKNASSDVFFNASLEDIDSEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQGSILTNKYAEGYPGKRYYGGCQYVDVVEELAIERAKKLFGCEFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRKDDHLLDMDEVARLARENKPKLILAGGTAYSRVWDWKRFREIADEVGAYLMVDMAHIAGLVAGGVHPSPVPHAHVCTTTTHKSLRGPRGGMILTNDADIAKKINSAVFPGLQGGPLMHVIAGKAVAFAEALKPEFKLYAKNVVDNARALAEELKSNGLDIVSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFGVTEFKEIGSLIAEVLDGLKVANSDEGNAAVEQAVKEKVMALTDRFPMYGYQG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2677_NITOC
Sequence: MDKKLLEILACPVCKSSLIYKKADQELICKACRLAYPIRDDIPVMLEEQARQFDPEEEI
What are the official names of this protein?
UPF0434 protein Noc_2677.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: TOP3_ECOLI
Sequence: MRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKSPPADEVGSGAIA
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.  TOP3 is a potent decatenase.
What are the official names of this protein?
DNA topoisomerase 3, DNA topoisomerase III.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: GUNB_CALSA
Sequence: MKRNLFRIVSRVVLIAFIASISLVGAMSYFPVETQAAPDWSIPSLCESYKDDFMIGVAIPARCLSNDTDKRMVLKHFNSITAENEMKPESLLAGQTSTGLSYRFSTADAFVDFASTNKIGIRGHTLVWHNQTPDWFFKDSNGQRLSKDALLARLKQYIYDVVGRYKGKVYAWDVVNEAIDENQPDSYRRSTWYEICGPEYIEKAFIWAHEADPNAKLFYNDYNTEISKKRDFIYNMVKNLKSKGIPIHGIGMQCHINVNWPSVSEIENSIKLFSSIPGIEIHITELDMSLYNYGSSENYSTPPQDLLQKQSQKYKEIFTMLKKYKNVVKSVTFWGLKDDYSWLRSFYGKNDWPLLFFEDYSAKPAYWAVIEASGVTTSSPTPTPTPTVTVTPTPTPTPTPTVTATPTPTPTPVSTPATGGQIKVLYANKETNSTTNTIRPWLKVVNSGSSSIDLSRVTIRYWYTVDGERAQSAVSDWAQIGASNVTFKFVKLSSSVSGADYYLEIGFKSGAGQLQPGKDTGEIQIRFNKSDWSNYNQGNDWSWLQSMTSYGENEKVTAYIDGVLVWGQEPSGATPAPTMTVAPTATPTPTLSPTVTPTPAPTQTAIPTPTLTPNPTPTSSIPDDTNDDWLYVSGNKIVDKDGRPVWLTGINWFGYNTGTNVFDGVWSCNLKDTLAEIANRGFNLLRVPISAELILNWSQGIYPKPNINYYVNPELEGKNSLEVFDIVVQTCKEVGLKIMLDIHSIKTDAMGHIYPVWYDEKFTPEDFYKACEWITNRYKNDDTIIAFDLKNEPHGKPWQDTTFAKWDNSTDINNWKYAAETCAKRILNINPNLLIVIEGIEAYPKDDVTWTSKSSSDYYSTWWGGNLRGVRKYPINLGKYQNKVVYSPHDYGPSVYQQPWFYPGFTKESLLQDCWRPNWAYIMEENIAPLLIGEWGGHLDGADNEKWMKYLRDYIIENHIHHTFWCFNANSGDTGGLVGYDFTTWDEKKYSFLKPALWQDSQGRFVGLDHKRPLGTNGKNINITTYYNNNEPEPVPASK
What is the function of this protein?
This protein is made up of two domains: the N-terminal domain has exoglucanase activity while the C-terminal domain is an endoglucanase.
What are the official names of this protein?
Endoglucanase/exoglucanase B.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glycosyl hydrolase 5 (cellulase A) family.