PharMolix/UniProtQA huggingface dataset:
Protein: TMM43_HUMAN
Sequence: MAANYSSTSTRREHVKVKTSSQPGFLERLSETSGGMFVGLMAFLLSFYLIFTNEGRALKTATSLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESREYTEDGQVKKETRYSYNTEWRSEIINSKNFDREIGHKNPSAMAVESFMATAPFVQIGRFFLSSGLIDKVDNFKSLSLSKLEDPHVDIIRRGDFFYHSENPKYPEVGDLRVSFSYAGLSGDDPDLGPAHVVTVIARQRGDQLVPFSTKSGDTLLLLHHGDFSAEEVFHRELRSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWALLIAGLALVPILVARTRVPAKKLE
What is the function of this protein?
May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane.  Required for retaining emerin at the inner nuclear membrane (By similarity).  Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325).  In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (PubMed:27991920).  Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination (PubMed:34050020).
What are the official names of this protein?
Transmembrane protein 43, Protein LUMA.
What is the protein family that this protein belongs to?
Belongs to the TMEM43 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity).
Protein: RL15_PYRAR
Sequence: MVRRFKRAVKYRRGSRTHGWGRVGQHRKSGGSGGKGMVGFHKHKWSLVMKYGESGTGWPFYGKHGFKQPPTITVEWRPINVGTLAEVVRELKSEGKIREEGGKYVVNLLELGYNKLLGGGSIDVPVIVYTPVASKTAVEKIQRAGGEVRVVAIHR
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RL9_CUPNH
Sequence: MQIILLEKVINLGNLGDIVKVKDGYARNFLIPGKKARRATQTAIAEFEVKRAELEKAAAEKLAAAQAEGEKLSGLSVQISQKSGVDGRLFGSVTNADIAEALAGQGFKLEKAQVRMPNGPLKMVGDHPVSVALHTDVVVDVTVSVVGESV
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: TRMN6_PHOV8
Sequence: MPNPYFSFKQFTVYHDRCAMKVGTDGVLLGAWADVVSARNILDIGTGTGLISLMMAQRCNARIRAVDIDADAVEQARGNVAASPWQDRIEVELQDICHFTSETLFDVIVSNPPYFTDSLKCPGKQRNIARHTDFLDFDKLAGSAARLLHPEGVFSVIIPADGKESFLMAATRYGLHLSHQTFIHTKPGSEPKRVLLAFKFSVDKCVIDDLTIELSRHVYSEEYIALTKEFYLNM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPE_MYCTO
Sequence: MTLVLVIDDEPQILRALRINLTVRGYQVITASTGAGALRAAAEHPPDVVILDLGLPDMSGIDVLGGLRGWLTAPVIVLSARTDSSDKVQALDAGADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQPVIETDSFTVDLAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGRGELLKEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA
What is the function of this protein?
Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon.  Upon phosphorylation by KdpD, functions as a transcription regulator by direct binding to promoter regions of target genes to positively regulate their expression.
What are the official names of this protein?
Transcriptional regulatory protein KdpE.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDS_THEMA
Sequence: MKIGFLSRWGATCGVGMHAEILAREFIRMGHEVVVFAPTEESASKEVKYYKRTEAQDPEFVKREIYTEVDNVTEEGWVKEEEILKENLDLLIIETFWRVPVKPLTRLIEKLKIPVISVFHEANIFKAREVVKLPCDKIVVFDRRFYDEILEFYEIPREKVEVISYPVMKPYDAEPERPVSEDKFLFFSFGRQPVEEYCDFLNALKKLRKRFDNVHYWIIRSDGRVDYEAEWITQWQKRPTVEKLYSYLKGSNVHLLPKGNTPNVVVSSTLYQIIASETPIVIRDSRFVETIETDVYGFGPIVKYRNIHDLVHKLELLMLDRELVEDIKKEVRVFVEKYGGDKIAQEFLDLAKTITK
What is the function of this protein?
Catalyzes the transfer of the mannosyl group from GDP-mannose to di-myo-inositol-1,3'-phosphate (DIP), producing mannosyl-di-myo-inositol phosphate (MDIP).  Can also use MDIP as an acceptor of a second mannose residue, yielding di-mannosyl-di-myo-inositol phosphate (MMDIP).  Minor amounts of the tri-mannosylated form are also formed.
What are the official names of this protein?
GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase, MDIP synthase.
What is the protein family that this protein belongs to?
Belongs to the MDIP synthase family.
Protein: YEGS_PSEF5
Sequence: MSERKALLILHGKQALNEEVRAAVEARRAAGWDLQVRLTWEAGDAQRLVQEALAAGHTRLIAGGGDGTLRDIAEALANADAPASLVLLPLGTANDFARAAGVPLTPAAALDLLDVPARAIDLGEVGGQMFLNMATGGFGSQVTANTSEDLKKVLGGAAYLFTGLSRFAELSAAYGELQGPGFHWHGELLALGIGNGRQAGGGHELCPGALADDGLLDISILPAPQELVGTLKNLLAGGLGIDNLFVRARLPWVEIKASRGLDINLDGEPLQGDTLRFTARPGALRVHLPEDSPLLGGAR
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS-like.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_PROMP
Sequence: MRIIFWGTPEYSVKSLEVLKKSDHDIVAVITQPDKKRSRGNKLISSPVKEYATKENIPVFTPETIKENIQFISILNDLSCDLFIVIAYGKILPKAILDIPKYKSWNAHASLLPRWRGAAPIQWSILEGDKITGVGIMRMEEGLDTGDVLVEKQIKIENNDNLKTLTKKLSDLSSELFLRAISDIEQNKNRDINLLLKKQTDFKRELKYARMINKLDYIINWENSATDIYRKINALYPRANTTYKRKNLKIIKIKILTTHEIHNKNYKILSNVFKPGLIIGLIKNVGIIITTKTDPILLLEAKLEGKKVSSQNQLIQQLNPVIGENFSD
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RRP41_METTH
Sequence: MITIITQDQLKTSPSVREDGRAFDELRPLKIEAGILERADGSSYLEFGGNKILVAVYGPREAQIRKLQRPDRAVIRCRYNMAPFSVEERKRPGPDRRSVEISKITAEALRPALILEKFPRSVIDVFIEVLEAEGGTRCAGITAASVALADAGIPMRDMVVACAAGKVGDQVVLDLSEEEDKEGQADVPVAILPRTREITLLQSDGNLTPEEFERALDLAVEGCLRIHEVQKEALRKRYGE
What is the function of this protein?
Catalytic component of the exosome, which is a complex involved in RNA degradation.  Has 3'->5' exoribonuclease activity.  Can also synthesize heteromeric RNA-tails.
What are the official names of this protein?
Exosome complex component Rrp41.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp41 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AP2A_YEAST
Sequence: MDRKKTLINSSVSNNNSTIKGLQLFIADLRSAQQAQEQEKRIQSEIVKIKQHFDAAKKKQGNHDRLGGYQRKKYVAKLAYIYITSNTTKLNEILFGLEQTVELLKSSIFSEKFIGYMTLELLYERSEVVAKVNDEVNYQLMKDLSSSDDNFVMLALNFVGVVGELTNRLAYNDDITTGVFKILRSPTSSIYLKKKSALSFLALLKSNHSILTEDLQRKQLWIQRILSLLDDTENYRLTLATIPLIEFIAKYIDPSYCTRLLPQLTEILYNCVVVGTSRSSDNQFPLEYTFANMPNPWLITKVVSLLSILIASPTERDSGSLLQTNNIDNELLNKLRKCVSVAIELGTRQAQDPMERIVQNTVLFSLINFASKLDPSDEAISNSVTALCSLLTSKEINIRYLTLDSLVKLCSSSGKPAIDAVRYKNLDMIFHLLNTERDSSIVRKVVDLLYTFTDVENVKIIVDGLLQYILSPKNLAEPQIKSDIAVKIAILTEKYATDINWFVIISLQLLSLTSNTTINDDEIWQRLCQIVVNNPSLHRITCERLVDYLCKKQASEAIIKAAAFLLGEYSSLITDRISSANLFTLFAEKYFSAPNVAKAMILTTMIKLYKTSPEIGSNVIKFFQLELNSLDIELQTRSFEYLNIIQLAKVNGNTDILQILFEPMPPFNSKSNPLLKRLGSLPASAGSTTLINTPSEASSSTPDLLSKRANSSRSIMVPMPPPSRRNTIDDVNSKISSSEDFSGKDSYYSRQILAPNWREGFTRMISHKQGVLFTSSLMKVFYRITTPDAQQPYVFHISLAFINLTEWEITGLSTQIIPSKTQGNPEYLIMNINTPSTATIGPHKRAEQSYEVSIRKPFDVEDSPILAIHFKCGGSTNTINLKTAIGMTTTLISSDVNPSMHLNLAQFISRWKTLSDALGKEGEYQKSGIKLNKDFRKVETISLEDGLLLLTQTVKRLGFDIVDQTSVRSTLFVSGIIHTKSEGNFGCLMKIQYQVNGTVNVTCKTTTAGPLAKYIVECIKNVLTK
What is the function of this protein?
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles.  Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.  Alpha adaptin is a subunit of the plasma membrane adaptor.  Facilitates interaction between APL1 and APS2.
What are the official names of this protein?
AP-2 complex subunit alpha, Alpha-adaptin, Clathrin assembly protein complex 2 alpha large chain, Clathrin assembly protein large alpha chain.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Protein: YCIH_SALTY
Sequence: MSDSNSRLVYSTQTGRIEEPKTAPVRPKGDGIVRIQRQTSGRKGKGVCLITGIEMNDAELTKLAAELKKKCGCGGAVKEGIIEIQGDKRDLIKSLLEAKGMKVKLAGG
What are the official names of this protein?
Uncharacterized protein YciH.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: PEBB_HUMAN
Sequence: MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTTRP
What is the function of this protein?
Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3).  RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.  The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters.  CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development.  They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
What are the official names of this protein?
Core-binding factor subunit beta, CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit.
What is the protein family that this protein belongs to?
Belongs to the CBF-beta family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMM_MYCMM
Sequence: MELVIGRVVKAHGITGEVVVEIRTDEPDRRFTPGASLRAKRSRDGGTGRNYVIEGVREHGARLLVRLAGVNDRDTADGLRGSLFVIDSADLPPIDEPDTYYDHQLEGLRVRTTAGQDVGVVAEVLHTGAGELLAVKCDSGEVLVPFVGAIVTSVSLDDRILEIDPPDGLLDLGS
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEP_I83A1
Sequence: MDPNTVSSFQDILMRMSKMQLGSSSGDLNGMITQFESLKLYRDSLGEAVMRMGDLHSLQNRNGKWREQLGQKFEEIRWLIEEVRHKLKITENSFEQITFMQALQLLFEVEQEIRTFSFQLI
What is the function of this protein?
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs).  Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell.  Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain.  This domain is believed to allow recognition of RNPs bound to the protein M1.  Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized.  Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane.  May down-regulate viral RNA synthesis when overproduced.
What are the official names of this protein?
Nuclear export protein, NEP, Non-structural protein 2, NS2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses NEP family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: HSE1_EMENI
Sequence: MFRAQQNAFDDAVAKATDENLTSENWEYILDVCDKVGAEESGAKDAVAALIKRLAHRNANVQLYTLELANALAQNCGPKIHRELASRSFTDALLRLAGDRNTHQQVKSKILERMEDWTEMFASNPDFGIMEQAFMKLRTQNPNLQPPSKPGKREITDLDRQKEEEELQMALALSIREKSGSAPQPQVESSSSVSAPENQAQAAPAGPVPSGTSAATVSRVRALYDFQPSEPGELQFRKGDVIAVLESVYKDWWKGSLRGQTGIFPLNYVEKLPDPTVEELQREAQMEAEVFGQIKNVEKLLTLLSTRSSELNVQENEEITNLYNSTLSIRPKLVELIGKYSQKKDEFTQLNEKFIKARRDYESLLEASMAQPPQQQFGRPGQPQYGYPGSGAPAGYPRGPAQQHDPQRYFSPRPPDNQPNASYYPPATQSPGPGHTSPPGPYQQQPQQPAPDSYQPVHHRPESTYDQPQELGTSVYDSPVERLQYPPGPSGGQPHYQPPPQQTPQPDFSASSPNLVNQSQSPYPATPVTQPPPPTQQPPPVPGTASGSAPYPSASPSAANYQAYRPPQGGIPNHNPAAFYQ
What is the function of this protein?
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
What are the official names of this protein?
Class E vacuolar protein-sorting machinery protein hse1.
What is the protein family that this protein belongs to?
Belongs to the STAM family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RS12_BORPE
Sequence: MPTISQLVRKPREVSIIKSKSPALENCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTNGYEVISYIGGEGHNLQEHSVVLVRGGRVKDLPGVRYHIVRGSLDLQGVKDRKQARSKYGAKRPKKA
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RL19_SHEWM
Sequence: MNNIIKMLNEEQMKKDVPEFGAGDTVVVKVRVVEGGKERLQAFEGVVIAKRNRGVHSAFTVRKISNGEGVERAFQTHSPIISDIEVKRRGRVRRAKLYYLRERSGKSARIREKLSTK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ATPD_PSE14
Sequence: MAELTTLARPYAKAAFEHAQAHQQLANWSAMLGLAAAVSQDDTMQRMLKAPRLTSAQKATTFIEVCGEKFDAKAQNFIHVVAENDRLPLLPEIAELFDLYKAEQEKSVDVDVTSAFALNQEQQDKLAKVLSARLGREVRLHAAEDASLIGGVVIRAGDLVIDGSVRGKIAKLAEALKS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NMO_STAA8
Sequence: MWNKNRLTQMLSIEYPIIQAGMAGSTTPKLVASVSNSGGLGTIGAGYFNTQQLEDEIDYVRQLTSNSFGVNVFVPSQQSYTSSQIENMNAWLKPYRRALHLEEPVVKITEEQQFKCHIDTIIKKQVPVCCFTFGIPSEQIISRLKAANVKLIGTATSVDEAIANEKAGMDAIVAQGSEAGGHRGSFLKPKNQLPMVGTISLVPQIVDVVSIPVIAAGGIMDGRGVLASIVLGAEGVQMGTAFLTSQDSNASELLRDAIINSKETDTVITKAFSGKLARGINNRFIEEMSQYEGDIPDYPIQNELTSSIRKAAANIGDKELIHMWSGQSPRLATTHPANTIMSNIINQINQIMQYK
What is the function of this protein?
Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates.  Acts on propionate 3-nitronate (P3N), the presumed physiological substrate.  Probably functions in the detoxification of P3N, a metabolic poison produced by plants and fungi as a defense mechanism.
What are the official names of this protein?
Probable nitronate monooxygenase, NMO, Propionate 3-nitronate monooxygenase, P3N monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the nitronate monooxygenase family. NMO class I subfamily.
Protein: HIS4_BURO0
Sequence: MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLEAIEAILDEVGDEIPVQLGGGIRSLETIEKYLDAGLSYVIIGTAAVKNPGFLQDACTAFSGSIIVGLDAKDGKVATDGWSKLTGHEVIDLAKKFEDYGVESIVYTDIGRDGMLQGINIDATVKLAQAVGIPVIASGGLSNLTDIESLCEVEEHGVEGVICGRAIYSGDLDFAAAQKRADELNGELDNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
Protein: VF385_ASFM2
Sequence: MDEIINKYQAVEKLFKEIQEGLAAYDQYKTLISELLHYNNHIKQEYFNFLMIISPYLIRAHSGETLRNKVNNEIKRLILVENINTKISKTLVSVNFLLQKKLSVDGVKTKNMWCTNNPMLQVKTAHNLFKQLCDTQSKTQWVQTLKYKECKYCHTDMVFNTTQFGLQCPNCGCIQELMGTIFDETHFYNHDGQKAKSGIFNPNRHYRFWIEHILGRNSEQELGTKQDPCGTKVLQQLKKIIKRDNKCIALLTVENIRKMLKEINRTDLNNCVSLILRKLTGVGPPQISESILLRGEYIFTEAIKIREKVCKKGRINRNYYPYYIYKIFDAILPPNDTTNRRILQYIHLQGNDTLANNDSEWESICMELPEIKWKPTDRTHCVHFF
What are the official names of this protein?
Zinc finger protein B385R, pB385R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus B385R family.
Protein: HEM2_STAAM
Sequence: MKFDRHRRLRSSATMRDMVRENHVRKEDLIYPIFVVEKDDVKKEIKSLPGVYQISLNLLESELKEAYDLGIRAIMFFGVPNSKDDIGTGAYIHDGVIQQATRIAKKMYDDLLIVADTCLCEYTDHGHCGVIDDHTHDVDNDKSLPLLVKTAISQVEAGADIIAPSNMMDGFVAEIRRGLDEAGYYNIPIMSYGVKYASSFFGPFRDAADSAPSFGDRKTYQMDPANRLEALRELESDLKEGCDMMIVKPALSYLDIVRDVKNHTNVPVVAYNVSGEYSMTKAAAQNGWIDEERVVMEQMVSMKRAGADMIITYFAKDICRYLDK
What is the function of this protein?
Catalyzes an early step in the biosynthesis of tetrapyrroles.  Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
What are the official names of this protein?
Delta-aminolevulinic acid dehydratase, ALAD, ALADH, Porphobilinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the ALAD family.
Protein: GET3_LACBS
Sequence: MSTDLLPPTLQNILDQTSLKWIFCGGKGGVGKTTTSCSLAIQLAKCRKSVLLISTDPAHNLSDAFGQKFSKDATKVNGFDNLFAMEIDPTSAIQEMVEQCMLADSNGMMGSMMQDLAFAIPGVDEAMSFAEIMKHVHVKSMEYSVIVFDTAPTGHTLRFLSFPTVLEKALGKLSSLGSRFGPMISQMSSMMGGEAGSQEDMFAKLESMRGVITEVNTQFKDPEKTTFVCVCISEFLSLYETERLVQELTAYEIDTHNIVVNQLLFPKKSSNCEHCSVRQKMQQKYLAEAHELYDEFFHIIQLPLLTEEVRGPEKLNEFSKMLVEPYVTPE
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: MURG_FRAP2
Sequence: MNLKDKNIIITAGGTGGHIYPALAVAEMLRENNANVTWVGTPNSMEANIVPEYFNMQYIKSSGVRGKGLKRKVAFPFTLISSTLKARKILKKLKIDLVIGFGGYVSGPICLAAVQKDIPIIIHEQNAKIGLTNRILAKLATKVCLAFDVEDIQKRLSPKQLAKTQVVGNPIRKDIIALNNKTKNITENGKLKLLVLGGSQGAKSINNIIPDLIIEANKQGISLKVWHQTGKLSFEETKNNYNQVPSTHIKDISAYITDMTNAYEWADILICRAGALTVSESAIAGVPAIFIPLPSAVDDHQFFNAQNMVKNNAGFCIRQDQMTLENLIDIIKPLYEDRDKLKEISQKAKNTLIKDSSEQILKAVEQILNKK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: YOBD_ECOLU
Sequence: MTITDLVLILFIAALLAFAIYDQFIMPRRNGPTLLAIPLLRRGRIDSVIFVGLIVILIYNNVTNHGALITTWLLSALALMGFYIFWIRVPKIIFKQKGFFFANVWIEYSRIKAMNLSEDGVLVMQLEQRRLLIRVRNIDDLEKIYKLLVSTQ
What are the official names of this protein?
UPF0266 membrane protein YobD.
What is the protein family that this protein belongs to?
Belongs to the UPF0266 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DGGGP_KORCO
Sequence: MGKLGAYVEISRPKNALMSILGTLTGWVNSTSVYDGRLILACLIPPLVLMAGNAINDYYDAEIDAINKPYRPIPSGRISKREALNIYIALSLFGIALSIFLGFIEFLIVTAFSLSWYAYARWLKRTGVPGNALVSLGVAFTLIFGSLAAGNLTNKVIIFSSVAFTSNLIREFVKAVEDLPGDRAHGVRTIAVRIGVKRTGILVFLLSLATVVLTILPVIFRLTGIIYLSLSVIISLPILMLASAICLKGKLEERARETSSLIKVSMFLGLLGMLLDPFRVV
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP).  This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Digeranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PANC_YERPN
Sequence: MLIIETLPLLRQQIRRWRQEGKRIALVPTMGNLHEGHMTLVDEAKTRADVVVVTIFVNPLQFERPDDLAHYPRTLQEDCEKLTRHGADLVFAPAAADIYPAGLEKQTYVDVPALSTILEGASRPGHFRGVSTIVSKLFNLIQPDVACFGEKDYQQLALIRKMVADMGYDINIVGVPTVRAKDGLALSSRNGYLTEEERQIAPQLSKIMWALAEKMALGERQIDALLEEAAAQLLRVGFTPDELFIRDAETLQPLTVDSQQAVILMAAWLGKARLIDNQLVDLRH
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.