PharMolix/UniProtQA huggingface dataset:
Protein: TRT1_ASPTN
Sequence: MPSIISDPQAYDIMLRLLQFSCWSLSYINTVRTTLSDQLPSVSFMSICCDVAWEFVYAFVYPIASSHWAGGIRIWFAMHCVMLFIVAKYAPNDWDHVPLMKRFARLAYVAITIGFMAGHLALASEIGPALGFFWSGALCQITASLGSLCLLVCRGSTRGASIKTCPLCWFYIAITLTLDAIYPVFFFYFRAIEHPKKDSERKVE
What is the function of this protein?
Terpene cyclase; part of the gene cluster that mediates the biosynthesis of terretonin, a fungal meroterpenoid that acts as a mycotoxin (PubMed:22549923, PubMed:23116177, PubMed:25671343).  The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase trt4 (PubMed:22549923, PubMed:23116177).  DMOA is then prenylated into farnesyl-DMOA by the polyprenyl transferase trt2 (PubMed:22549923, PubMed:22782788, PubMed:23116177).  Methylation by the methyltransferase trt5 then leads to farnesyl-DMOA methyl ester which is further subject to epoxidation by the FAD-dependent monooxygenase trt8 to yield epoxyfarnesyl-DMOA methyl ester (PubMed:22549923, PubMed:22782788, PubMed:23116177).  Cyclization of epoxyfarnesyl-DMOA methyl ester by the terpene cyclase trt1 leads to a tetracycle intermediate which is in turn converted to preterretonin (PubMed:22549923, PubMed:22782788, PubMed:23116177).  Dehydrogenase trt9 comes next to transform preterretonin to preterrenoid (PubMed:22549923, PubMed:23116177).  The FAD-dependent monooxygenase trt3 is then required for the C-hydroxylation at C16 of preterrenoid to yield terrenoid (PubMed:22549923, PubMed:23116177).  The cytochrome P450 trt6 catalyzes three successive oxidations to transform terrenoid into an unstable intermediate, which then undergoes the D-ring expansion and unusual rearrangement of the methoxy group to afford the core skeleton of terretonin (PubMed:25671343, PubMed:28759016).  Trt14 catalyzes the D-ring expansion of terretonin involving intramolecular methoxy rearrangement as well as the hydrolysis of the expanded D-ring and the methyl ester moiety (PubMed:25671343, PubMed:28759016).  Finally, the nonheme iron-dependent dioxygenase trt7 accomplishes the last two oxidation reactions steps to complete the biosynthesis of terretonin (PubMed:25671343).  Terretonin C is produced via spontaneous decarboxylation of the terretonin precursor (PubMed:23116177).  Another shunt product of the terretonin biosynthesis is dihydrofarnesyl-DMOA, derived from epoxyfarnesyl-DMOA through hydrolysis of the epoxide (PubMed:22549923, PubMed:22782788, PubMed:23116177).
What are the official names of this protein?
Terpene cyclase trt1, Terretonin synthesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the paxB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: EIF3D_MAGO7
Sequence: MSQSLADIIAALPDGDGWGPAVTTELTLNGVPYAPFSKGDKLGRMADWTDGKDRDGRGGRQQYNRNFRDQQVYGAGTASLFSAPQAEDESTFSVVSNVRDSTKTRFGRGAVFTRGGRGQRGARGTERGGRAQLSRGRGGQYGGGYDRGGRSAAGGRGGRRFGWKDYDKPARNRDASINVKADWSLLEEIDFNRLGKLNLDADEGEDVDSYGFVHYYDRSYDKPAVKSAERKLNPIDRAAYNVTTSLDPVIQELAEKDEATIFATDNILSTLMCAPRSVYPWDIVIVKQGSKVYFDKRDNAALDMVTVNENAVDAPLEASEGSKDSINQPSALAEEATYINHNFVNQVVIENESQKVDMEHENPFYNAAEETEPPASKAYKYRKFDLSTNDEGPVYLVVRTELDAVQKNSNNGEDQFLTVRALNEFDNKAQGSGGALDWRSKLVSQRGAVVATEMKNNSCKLAKWTVQSILAKADVLKLGFVSRANPKSNDKHVILGVIGWKPKDFANQMNLHLSNGWGIVRTIADMCLKREDGKYVLVKDPNKTILRLYEVPAGGLDEEEDNGDLGQEEDDEE
What is the function of this protein?
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.  In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit D, eIF3d.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit D family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTN4_HUMAN
Sequence: MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL
What is the function of this protein?
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures.  This is a bundling protein (Probable).  Probably involved in vesicular trafficking via its association with the CART complex.  The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161).  Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2.  Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity).  May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).
What are the official names of this protein?
Alpha-actinin-4, Non-muscle alpha-actinin 4.
What is the protein family that this protein belongs to?
Belongs to the alpha-actinin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell junction. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, perinuclear region. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU- 7).
Protein: SCRA2_ARALY
Sequence: MRCVVLFMVSCLLIVLLINHFEEVEAQKWKECNLRDIFPGKCEHDANAKLRCKEDIAKNFRPSRPFECDCQTFDQGRICYCKKCLV
What is the function of this protein?
Involved in male-mediated self-incompatibility.
What are the official names of this protein?
Defensin-like SRCA-homolog protein, S locus cysteine-rich-like protein 37, AlSCR37.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: TO1C_HADIN
Sequence: SSTCIRTDQPCPYNESCCSGSCTYKANENGNQVKRCD
What is the function of this protein?
Inhibits insect, but not mammalian, voltage-gated calcium channels (Cav).
What are the official names of this protein?
Omega-hexatoxin-Hi1c, Omega-HXTX-Hi1c, Omega-atracotoxin-Hi1c, AcTx-Hi1, Omega-AcTx-Hi1c.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 08 (Shiva) family. 01 (omega toxin) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: DAPE_SALNS
Sequence: MSCPVIELTQQLIRRPSLSPDDAGCQALMIERLRKIGFTIEHMDFGDTQNFWAWRGRGETLAFAGHTDVVPAGDVDRWINPPFEPTIRDGMLFGRGAADMKGSLAAMVVAAERFVAQHPHHRGRLAFLITSDEEASAKNGTVKVVEALMARNERLDYCLVGEPSSTEIVGDVVKNGRRGSLTCNLTIHGVQGHVAYPHLADNPVHRAAPFLNELVAIEWDRGNDFFPATSMQVANIQAGTGSNNVIPGELFVQFNFRFSTELTDEMIKERVHALLEKHQLRYTVDWWLSGQPFLTARGKLVDAVVNAIEHYNEIKPQLLTTGGTSDGRFIARMGAQVVELGPVNATIHKINECVNAADLQLLARMYQRIMEQLVA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: DDL_BURPS
Sequence: MSGIDPKRFGKVAVLLGGDSAEREVSLNSGRLVLQGLRDAGIDAHPFDPAQRPLAALKDEGFVRAFNALHGGYGENGQIQGALDFYGIRYTGSGVLGSALGLDKFRTKLVWQQTGIPTPPFETVMRGDDYAARAQDIVAKLGVPLFVKPASEGSSVAVEKVKSADALPAALEEAAKHDKIVIVEKSIEGGGEYTACIAADLDLPLIRIVPAGEFYDYHAKYIANDTQYLIPCGLDAAKEAEFKRIARRAFDVLGCTDWGRADFMLDAAGNPYFLEVNTAPGMTDHSLPPKAARAVGIGYSELVVKVLSLTLD
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_BORT9
Sequence: MLLRLYNTKTKSLSEVKNFSDIKVYACGPTVYNYAHIGNFRTYIFEDLLIKSLRLLKYNVNYAMNITDIGHLTGEFDEGEDKVVKAARERGLTVYEISRFFTEAFFCDCEKLNIVRPDKVLIASEYIASMIEVIKVLEQNGFTYFVNGNVYFDTSLFKSYGQMAGINLNDFEFSSVSRVEVDPSKKNKSDFVLWFTNSKFKDQEMKWDSPWGFGYPSWHLECAAMNLDCFRSTLDIHLGGVDHIGVHHINEIAIAECYLNRMWCDIFVHGEFLIMEDEKMSKSNNNFITIQDLETNGFSPLDFRYFCLTAHYRTQLKFTFNNLRACKVARKNMLNKLTAVFSSLNQFDLLLLSKNYENIESVLEKRYYDSFLEKIAFDLSIPQALALLWDIIKDDNLSALSKLRLTFKFDEVLSLGLKEGVFREIEKDRINIDDAMNSLLEERRLAKIRKDFKRADEIREYFYSKGFVLIDTEEGTKVKRG
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG5_PIG
Sequence: METQRASLCLGRWSLWLLLLGLVVPSASAQALSYREAVLRAVDRLNEQSSEANLYRLLELDQPPKADEDPGTPKPVSFTVKETVCPRPTRQPPELCDFKENGRVKQCVGTVTLDQIKDPLDITCNEVQGVRGGRLCYCRPRFCVCVGRG
What is the function of this protein?
Microbicidal activity.
What are the official names of this protein?
Protegrin-5, PG-5.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MON1B_MACFA
Sequence: MEAGGDTAAPVPGGAEDLEDTQFPSEETREGGGVHAVPLDPEGEGLEETGSKDKDQPPSPSPPPQSEAPSSTSRLWSPAAPENSPTRSPESSSGGQGGDPSDEEWRSQRKHVFVLSEAGKPIYLRYGSVEALSATMGVMTALVSFVQSAGDTIRAIYAEDHKLVFLQQGPLLLVAMSRTSQSAAQLRGELLAVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRLLDSVEQDPGALLLGAVRCVPLARPLRDALGALLRRCTAPGLALSVLAVGGRLITAAQERNVLAECRLDPADLQLLLDWVGAPAFAAGEAWAPVCLPRFNPDGFFYAYVARLDAMPVCLLLLGTQREAFHAMAACRRLVEDGMHALGAMRVLGEAAGFSNASSASAPAYSVQAVGAPGLRHFLYKPLDIPDHHRQLPQFTSPELEAPYSREEERQRLSDLYHRLHARLHNTSRPLRLIYHVAEKETLLAWVTSKFELYTCLSPLVTKAGAILVVTKLLRWVKKEEDRLFIRYPPKYSTPPAPSTDQAAHNGLFTGL
What are the official names of this protein?
Vacuolar fusion protein MON1 homolog B.
What is the protein family that this protein belongs to?
Belongs to the MON1/SAND family.
Protein: MT2_CRILO
Sequence: MDPNCSCATDGSCSCAGSCKCKECKCTTCKKSCCSCCPVGCAKCSQGCVCKEASDKCSCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
What are the official names of this protein?
Metallothionein-2, MT-2, Metallothionein-II, MT-II.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: RL9_SHESH
Sequence: MNVILLDKIANLGNLGDQVAVKAGYARNFLLPQGKAVVANTANTEVFEARRAELEAKLVADLTAANERAEKINALESIVIASKAGDEGKLFGSIGNRDIADAVTAAGVELAKSEVRLPLGALRTTGEFEVEVQVHTEVKAIVKLSVVAED
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: LPXK_METFK
Sequence: MGQSFSRWLERQWYGHTGWQLILRPFSWLFYILIALRRLAYRLRLFKSLKLSVPVIIVGNINVGGTGKTPFVIWLVQQLRQNGWYPGIISRGYGGKSIHTHQVTKDSLPQEVGDEPVLLVQRTGLPLYVGRKRTRAARHLLRDYPECNLIISDDGLQHYALERDMEIVIIDGERIFGNGQLLPAGPLREPSSRLEDVDAVVFNGGPPAAGGYLMQLIPEDLRKVSAPQERMALNELIGQHVHAVAGIGNPQRFFGQLEQLGLVVEAHPFPDHHAYTEDDFEFAKDDIVLMTEKDAVKCIAFARENWWFMPISAEIDRALAEKILARLTRLMEKEI
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: HXA5_MOUSE
Sequence: MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSGSGHFGSGERARSYAAGASAAPAEPRYSQPATSTHSPPPDPLPCSAVAPSPGSDSHHGGKNSLGNSSGASANAGSTHISSREGVGTASAAEEDAPASSEQAGAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.  Also binds to its own promoter.  Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
What are the official names of this protein?
Homeobox protein Hox-A5, Homeobox protein Hox-1.3, Homeobox protein M2.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DHYS_SENVE
Sequence: MEESMKQASVMENLRSVVFKESESLEGTCAKIRGYDFNNGIDYSQILKSMVSTGFQASNLGDAIETVNQMLDWRLSHEQVTEDCSQEEKNPTYRESIKCKIFLGFTSNLISSGVRDIIRYLVQHHMVDVIVTTTGGIEEDLIKCLADTFKGEFSLPGAELRSKGLNRIGNLLVPNDNYCKFEDWIIPIFDQMLEEQKAKNVLWTPSKLIMRLGKEINNESSYLYWAYKNDIPVFCPGLTDGSLGDMLYFHTFRNPGLIVDVVQDIRAINSEAVHANPRKTGMIILGGGLPKHHICNANMMRNGADYAVFINTAQEFDGSDSGARPDEAVSWGKIRGSAKSVKVHCDATIAFPLLVAETFAAKREQSAEPSS
What is the function of this protein?
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.  Also able to produce homospermidine from putrescine.
What are the official names of this protein?
Deoxyhypusine synthase, DHS.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: SYK_BLOPB
Sequence: MTKYVYSKDQSYQKFNVDDELNIRRKKLSKLREKGVAFPNNFRRNSISNQLHKKYAHTSNVELIQLNIEVTIAGRIISQRIMGKASFITIRDAEGCIQLYITSNSLATNLYDENIKQWDLGDILGARGILFRTRTGELSIYCKEIRLLTKSLRPLPDKFHGLNNQETKYRQRYLDLIINENTRKTFKIRSLVISEIRQFMKKNNFMEVETPMMHTIAGGAIAHPFITHHNKLGIDMYLRIAPELYLKKLVIGGFERIFEINRSFRNEGISSYHNPEFTMMEIYMAYADYRDIIILVQNLLRSVTQKILGSNIINYGDYELDFKHPFTQISIKEAILYYLPETRSQNIDDICTAVSIAKSLGIKVKSCWTLHRIHMVIFEEVIEKKIIQPTCVTSYPIEISPLARRNDNNPEFADRFELFIAGREIGNGFSELNDPEDQKERFLKQAYGKKNKINNNNVHIHYDEDYLIALEYGLPPTAGIGIGIDRLIMLLTDSHTIRDVILFPTLRPK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB_PONPY
Sequence: VCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: LRN4L_MOUSE
Sequence: MLGSLSLLWLAAMTTSLVSQPQILTLEDYQEGEEDDVTVATPSLAVRCDYDRCRHLQVSCQELQKVGPVACLCPGLSREDQQPEPPRLGEVQIMAEEGYAVVHWCAPFSPVSHYWLLLWESNGAPQKSAPLNATVRRAELKGLKPGVAYVLCVVAANDAGESNVPGAEVEGPENWTGPSFGPCRKFIMPPKPVTLVYAAVGVGTALALLSCAALVWHFCLRERWGCPRRQGMAQASEAL
What are the official names of this protein?
LRRN4 C-terminal-like protein.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: UBIA_FRATN
Sequence: MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGCIINDIADVDFDKHVARTNTRPLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFVALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQIPVEAWIFYLATICWTIAYDTIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVVICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIMAVIQYI
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EX7S_DESDA
Sequence: MSAKNDNLFEKKLARLQEIVGALESGDLPLEKGMALYKEGATCARYCRQQLDKARHELEIWQDGQANPMSSQGHTAGEYPDDEAEEAEEA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBF_PSEFL
Sequence: MQLVRGLHNLRPEHRGCVATIGNFDGVHRGHQAILARLRERAVELGVPSCVVIFEPQPREFFTPETAPARLALARQAATAGGEGVDRVLCLAFNQRLRSLSAAEFVDRILVDGLGVQHLEVGDDFHFGCDRVGDFDFLQHAGVNQGFTVEAAQTVELDGLRVSSTQVRNALAAADFDLAERLLGRPFRIAGRVLHGQKLARQLGTPTANVQLKRRRVPLTGVYLVSVDIDGQSWPGVANIGVRPTVAGDGKAHLEVHLLDFAGDLYDRRLTVVFHQKLREEQRFASLEALKTAINADVAAARALAAPSAHR
What is the function of this protein?
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
What are the official names of this protein?
Bifunctional riboflavin kinase/FMN adenylyltransferase, Riboflavin biosynthesis protein RibF.
What is the protein family that this protein belongs to?
Belongs to the RibF family.
Protein: CH60_LYSSC
Sequence: MAKDIKFSEDARSLMLQGVDKLANAVKITLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELENPYENMGAKLVAEVASKTNEIAGDGTTTATVLAQAIIREGLKNVTAGANPVGIRKGIDKAVAAALTELHTISRPVSNKDEIAQVAAISAADDEVGQLIAEAMERVGNDGVITIEESKGFTTELDVVEGMQFDRGYASHYMVTDTDKMEAVLDNPYILITDKKITNIQEVLPLLEQVVQQGRPLLIIAEDVEGEALATLVVNKLRGTFNAVAVKAPGFGDRRKAMLEDIAILTGGQVITEELGLDLKSADISSLGRAAKVVVTKDNTTIVEGVGGADAIEARIGQIRAQLAETTSEFDKEKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVSGGGTALLNVYAAVEKVSESEEGDVATGVKIVLRALEEPVRQIANNAGLEGSIIVDRLKREEIGIGFNAATGEWVNMMEAGVVDPAKVTRSALQNAASVAALFLTTEAVVADIPEPAGAGMPDMSGMGGMPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJU2_YEAST
Sequence: MSERKAINKYYPPDYNPLEAEKLSRKMAKKLKTMNKSHASIRLMTPFSMRCLECNEYIPKSRKFNGKKELLKEKYLDSIKIYRLTISCPRCANSIAFRTDPGNSDYVMEVGGVRNYVPQKPNDDLNAKTAVESIDETLQRLVREKEMEQNEKMGIKEQADDKMDLLEKRLAKIQQEQEDDEELENLRKKNLEMSQRAEMINRSKHAQQEKAVTTDDLDNLVDQVFDNHRQRTNKPGNNNDEKRTPLFNPTSTKGKIQKKSSVRTNPLGIVIKRGKSLK
What is the function of this protein?
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:19935684, PubMed:27445308, PubMed:27459055, PubMed:29146871).  Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (PubMed:23438600, PubMed:27459055).  Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation (PubMed:29146871).
What are the official names of this protein?
Splicing factor YJU2.
What is the protein family that this protein belongs to?
Belongs to the CWC16 family. YJU2 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZRAB2_RAT
Sequence: MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSHSGSREHSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERDRKRSRSRPSSPAVRKKRRTRSRSPERHHRSSSGSTHSGSRSSSKKK
What is the function of this protein?
Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts.  May interfere with constitutive 5'-splice site selection (By similarity).
What are the official names of this protein?
Zinc finger Ran-binding domain-containing protein 2, Zinc finger protein 265, Zinc finger, splicing.
What is the protein family that this protein belongs to?
Belongs to the ZRANB2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MDTK_SALPB
Sequence: MQKYTSEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMAAVAIGTSIWLPAILFGHGLLLALTPVIAQLNGSGRRERIAHQVRQGFWLAGFVSVLVMIVLWNAGYIIRSMHNIDPALADKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFLGLLVNIPVNYIFIYGHFGMPELGGIGCGVATAAVYWVMFIAMLSYIKHARSMRDIRNETGFGKPDSVVMKRLIQLGLPIALALFFEVTLFAVVALLVSPLGIVDVAGHQIALNFSSLMFVLPMSLAAAVTIRVGYRLGQGSTLDAQTAARTGLGVGICMAVVTAIFTVTLRKHIALLYNDNPEVVALAAQLMLLAAVYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYILALTDLVVDRMGPAGFWMGFIIGLTSAAVLMMLRMRYLQRQPSAIILQRAAR
What is the function of this protein?
Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.
What are the official names of this protein?
Multidrug resistance protein MdtK, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYS_CLOBM
Sequence: MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNQVSSEVPKLKKEGKDVSNIVAEMKNLSEEIKGFDTTLAKIDEKIQYIMLRIPNIPNPQVPDGETDEDNIEIRNWSEPTKFDFEPKAHWDIGSNLNILDFERAGKVTGSRFTFYKGLGARLERSLISYFLDTHTEKHGYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTNLYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYRVVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILENYQNEDGSVTIPEVLRPYMGGKEAIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.