PharMolix/UniProtQA huggingface dataset:
Protein: RPOC1_SYNPW
Sequence: MTNSNLRTENHFDYVKITLASPDRVMEWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCEKIFGPSKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGFIKLAAPVSHVWYLKGIPSYVAILLDMPLRDVEQIVYFNCYVVLDPGDHKDLKYKQLLTEDEWLEIEDEIYAEDSEIENEPVVGIGAEALKQLLEDLTLDEVAEQLREEIAGSKGQKRAKLIKRLRVIDNFIATNARPEWMVLDVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLKMHQCGLPKEMAIELFQPFVIHRLIRQNIVNNIKAAKKLIQRADDEVMQVLQEVIDGHPIMLNRAPTLHRLGIQAFEPKLVDGRAIQLHPLVCPAFNADFDGDQMAVHVPLAIEAQTEARMLMLASNNILSPATGEPIITPSQDMVLGAYYLTALQPDVQPVDFGDRSRTFSDLEDVIHAFEDKRLGLHDWVWVRFNGEVEDDDEREEPVSSETLSDGTRFEQWTYRRDRFDDDGALISRYILTTVGRVVMNHTIIDAVAAT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: MOBA_METPP
Sequence: MIGAEHITGVVLAGGRGSRMGGVDKGLQPYRGIPLALHALMRLQPQVGTTMINANRNLAAYESFGVPVWPDTDPDFAGPLSGFLVGLERAETPFVVTVPCDTPDFPDDLVARLAHALEAEDAELAMVRAPDSADAPGAPRPQPVFCLLRSTLLESLVRFVHAGGRKIDRWTAQHRCAMVDFDAAPFFNANTLDELRRLETQRV
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMPP3_ARATH
Sequence: MPKPLVDFGNKPMILHQIEALKGAGVTEVVLAINHQQPEVMLNFVKEYEKKLEIKITFSQETEPLGTAGPLALARDKLVDESGQPFFVLNSDVICEYPLLEMIEFHKTNRAEASIMVTEVDDPSKYGVVVTEEGTARVESFVEKPKHFVGNKINAGIYLLSPSVLDRIELRRTSIEKEIFPKIASEKKLYAMVLPGFWMDIGQPKDYITGQRMYLNSLREKTPQELATGDNIIGNVLVHESAVIGEGCLIGPDVVIGPGCVIDSGVRLFGCTVMRGVWIKEHACISNSIVGWDSTVGRWARVFNITVLGKDVNVADAEVYNSGVVIEEQGL
What is the function of this protein?
Catalyzes a reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.
What are the official names of this protein?
Probable mannose-1-phosphate guanylyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: GLPK_BACAN
Sequence: MKKYILSLDQGTTSSRAILFNKKGEIVHSAQKEFTQHFPKPGWVEHNAQEIWGSILAVIATCLSEADVKPEQIAGIGITNQRETAVVWDKTTGKPIYNAIVWQSRQTAEICDELKEKGYSEMVREKTGLLIDAYFSGTKVKWILDNVEGAREKAENGDLLFGTIDTWLVWKLSGGKAHVTDYSNASRTLMFNIHDLQWDDELLDMLTVPKSMLPEVRPSSEVYGETIDYHFFGQNVPIAGVAGDQQAALFGQACFGEGMAKNTYGTGCFMLMNTGEKAVASEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGMRMFKDASESEVYASRVESTDGVYVVPAFVGLGTPYWDSEVRGAMFGVTRGTTKEHFIRATLESLAYQIKDVLCAMEADSGIELKTLRVDGGAVKNNFLMKFQSDILDVPVERPVINETTALGAAYLAGLAVGYWKNQDEIKEQWHMDKRFEPTMEAETSEELYAGWKKAIEATKAFK
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: RL24E_THEVO
Sequence: MLARTCSFCGKTIEPGTGIMYVRKDGAILYFCSNKCKKNMIGLNRVPRYVRWTNEYHELKKMRTRS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: CDKL2_MACFA
Sequence: MEKYENLGLVGEGSYGMVVKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFYKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCSELLHHDFFQMDGFAERFSQELQLKVQKDARNISLSKKSQNRKKEKEKDDSLGEERKTLVVQDTNADPKIKDCKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHIKIVPSTSLKDCSNVSVDHTRNPGVAIPPLMHNLSAVAPGINSGMGTATLPIQSYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSSEKSLFRASKKRREYSRTDVHLPELNYNHLPELRALEGTARNSRLTKKESKILSESRIPSLAAIDLHTPSITLHQVSGPPLSDDSGADLPQMEHQH
What are the official names of this protein?
Cyclin-dependent kinase-like 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ISK1_MONDO
Sequence: DQGRDANCNYEFPGCPRNLEPVCGTDGNTYNNECLLCMENKKRDVPIRIQKDGPC
What is the function of this protein?
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
What are the official names of this protein?
Serine protease inhibitor Kazal-type 1, Pancreatic secretory trypsin inhibitor.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPB_GALSU
Sequence: MSTIAQNKGYISQIIGPVIDIEFPNGTLPKIYNAISIKHKNKTITCEVQQLLGDNRVRTVAMNSTEGLQRGIEAIDTGSAITVPVGKCTLGRIFNVLGEPVDELGAISTDRKLPIHRASPLFTQLETKPSIFETGIKVIDLLAPYKRGGKIGLFGGAGVGKTVLIMELINNIAKSHGGVSVFGGVGERTREGNDLYVEMKESKVINEKNLEESKVALVYGQMNEPPGARMRVGLTALTMAEYFRDNNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLATEMGALQERITSTKEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRGLASKGIYPAVDPLDSTSTMLQPQIVGDEHYVTAQRVKENLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGSPGKYVSLKESIDGFKMILNGELDDLPEQAFYLVGNIQEAIKKADELKDK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: GCST_THEM4
Sequence: MKYTPLYEEHVKLGAKMVDFAGFNMPIQYTSIKDEVLAVRKNVGMFDVSHMGEVIVEGKDSTKFVDFLITNDFKNLKPGEIVYTAMCNENGGFVDDLLAYKISEEKAMLVINASNIEKDFSWMKKISESFDVTLENKSDEYVLIAVQGPNAQKTLQKITNVDLEQIGYYTFTEGNVLDIKAIISRTGYTGEDGFEIYTTDKDGIIKIWKKLLNLNVIPAGLGARDCLRLEASLLLYGNDMDETITPLEVGIKWAVKFEKDFMGKEALKRQLEEGTSRRLKGFKIIDKGIARHGYKVFKDGKEIGYVTSGTFSPTLNQAIGMALIEKGYKSGEIIEIEIRNKLVKAEIVKMPFYRGSVKSKKKG
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: RL15_RHOP5
Sequence: MKLSEIADNAGSRKKRMRVGRGIGSGKGKTAGRGGKGQTARSGVRIKGFEGGQMPLHRRLPKRGFNNIFRLDFAEINLDRLQEAIDAKAVDAGAVINAEVLVAAGVVRRAKDGVRLLGRGELKSKLTIEVYGASKPAIAAVEKAGGTVKILAPVKDEGEAA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RPOA_ECOL6
Sequence: MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQPEVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSLTEIKDVLASRGLSLGMRLENWPPASIADE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: SYI_SHEB8
Sequence: MSDYKFTLNLPETEFPMRGNLANREPEMLERWTKDGLYQQIRDSRIGRTPFILHDGPPYANGSIHIGHSVNKILKDIIIKSKTMSGFDAPYVPGWDCHGLPIELKVEQKVGKPGQKISAAEFREECRKYAAEQVNGQREDFIRLGVLGDWQNPYLTMDFSTEANIVRSLSKVIESGHLHKGVKPVHWCTDCGSALAEAEVEYEDKTSPAIDVAFVAADSKAVAAKFGVSGYSHPVSMVIWTTTPWTLPANRALSLSPELDYSLVEFEKDGVTQALILAEVLVESCLTRYNVESHTVLGSAKGAAFELVRFNHPFLDFDVPAILGDHVTTDAGTGIVHTAPGHGQDDFVVGQKYGLEVANPVGDNGVYKPDTEYFAGQHVFKANDNVVALLREKSALLNHVAYRHSYPHCWRHKTPIIFRATPQWFISMDNHGLRTQALKEIEQTQWIPDWGQSRIEKMVENRPDWCISRQRTWGVPITLFVNRETEELHSDSVSLMERVASRIEQQGIQAWWDLDAAELLGDEAEQYRKVTDTLDVWFDSGSTFSSVVAARPEFHGHGVDLYLEGSDQHRGWFMSSLMISTAMNGKAPYKQVLTHGFTVDGKGRKMSKSIGNVIAPQTVTNKLGADILRLWVAATDYSGEMTVSDEILNRSADAYRRIRNTARFLLANLNGFEPAKDLVAVEDMVALDRWVVRRAAALQQEIIEAYEQYNFHIVTQKLMQFCSVELGSFYLDIIKDRQYTAKQEGHARRSCQSALYLISEAMVRWIAPILSFTADEVWQLLPGERDAYVFTQEWYQGLKSVTLATDLSDDYWQQLLTVRNEVNKVIEQARRDKRIGGSLEAEVTLFADAALTEQLTHIGDELRFVLLTSEAKVLPLADATSEAVETELASLKLLVASSTAEKCERCWHHREEVGTIEAHPTLCTRCVTNIEGDGEVRLFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA4A_ORYSI
Sequence: MSRRYDSRTTIFSPEGRLYQVEYAMEAIGNAGSALGVLAADGVVLVGEKKVTSKLLQTSRSAEKMYKIDSHLACAVAGIMSDANILLNTARLHAQRYALSYQEPIPVEQLVQSLCDTKQGYTQFGGLRPFGVSFLFAGWDKHHGFQLYMSDPSGNYSGWKAAAVGANSQAAQSMLKQDYRDGMTREEAVALALKVLSKTMDSTSLTAEKLELAEVFLQPGTGEVQYQVCSPEAMGKLLAKAGLSQPAPEA
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-4-1, 20S proteasome alpha subunit C, 20S proteasome subunit alpha-3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RR14_JASNU
Sequence: MARKSLIQREKKRQQLEQKYHLIRRSSKKEISKIPSLSYKSEFYRKLQSPPRNSAPTRLHRRCFSTGRARAHYRDFGLSGYILREMFHACLLPGATRSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles.
What are the official names of this protein?
30S ribosomal protein S14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PHDK_NOCSK
Sequence: MTTPRKFDEYRWNVLVDGVPLNVESRYPISDPSTGRYLTQVPDCAEADVDRAVQASRQAQAEWGALPPRARAAKLRELITLLREHREEFAMLDAIDGGFPISMMRNDVDAALELMDIFADMALDLGGKTIPVSTNLHFTTHEPFGVVARIGAFNHPFFFAASKVAAPLMAGNSVILKAPDQTPLSSLRLAEVAAEVLPQNLLITISGRGRVAGRAIVRHPQIKRIGFIGSTDTGRSIQRDAAEVAVKHISLELGGKNAQIVFADADLEQAALGAVNGMNFTWTAGQSCGSTSRLLVHESVADQVIARVVELVSAIAVGPPLDENAQMGPLVSQAQYDKSVHAIGEGIREGAKVVAGGGRPEGVGEGGWYLAPTVLADVRPGSFIEQNEIFGPVLSVIIFATDDEAVAIANGVEYGLTASVWTSDITRAHLIARRVEAGYVLVNGGSRHYWGLPFGGVKSSGVGSEESMEELISYTETKTTTVVLG
What is the function of this protein?
Plays a role in phenanthrene catabolism by catalyzing the oxidation of 2-carboxybenzaldehyde to phthalic acid.  Not active with 3-carboxybenzaldehyde, 4-carboxybenzaldehyde, benzaldehyde, salicylaldehyde, 2-methylbenzaldehyde, 2-chlorobenzaldehyde, 2-fluorobenzaldehyde, 2-benzaldehydesulfonate, 2-methoxybenzaldehyde, 1-hydroxy-2-naphthoaldehyde or n-hexylaldehyde.
What are the official names of this protein?
2-formylbenzoate dehydrogenase, 2-carboxybenzaldehyde dehydrogenase, 2-CBAL dehydrogenase, 2-formylbenzoate:NAD(+) oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: PDH1_AGAXA
Sequence: MFPRVVRLNSRLVSFALLGLQIANGAITYQHPDDLPSNVNYDFIVAGGGTAGLVVASRLSENSDWNILVIEAGPSNKDTPETRVPGLADSLPGSRTDWNYTTIPQDALGGRSLNYSRAKVLGGCSTHNGMVYTRGSEDDWNYWAEVTGDQALSWDSVLPIMKKAEKFSQDFSDQSVDGHIDPAVHGRDGLLSVVASYTNVSFNDLLLQTTKELSDEFPFKLDLNDGKPHELAWTQYTIDHNAERSSSATSYLETTGDNVHVLVNTHVTRIVSAGNGTNFRSVEFAVDSNSPKKVLQAKKELILSAGVIASPQVLMNSGIGGREELQAIGVDTLIDNPSVGKNLSDQAATLLMFDTTLPNTDYDVAAALTEWDKSRSGPMAHGARLNHLTWVRLPDDKLNGSDPSSGKDSPHIEFQFRQISHQLPPADVPNQVQLPDPDSIGVVLQFSVVNLYSISPGSVILNDNDPFANPMIDLNMFGDQKDIAILREGVRSARRMFSSPAFKDVINGTVYPPADVTSDEDLDAFLRTSAESYWHGVGTLSMSPQNASWGVVNPDFRVKGTSGLRVVDASVIPRAPAGHTQVPVYTFAEHASVLIAASYH
What is the function of this protein?
Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin.  The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses to the corresponding C-1, C-2, C-3 or C-1,2, C-2,3 and C-3,4 (di)dehydro sugars with substrate-specific regioselectivity.  Accepts only a narrow range of electron acceptors such as substituted benzoquinones and complexed metal ions and reacts extremely slowly with O(2) as acceptor.  May play a role in the natural recycling of plant matter by oxidizing all major monosaccharides in lignocellulose and by reducing quinone compounds or reactive radical species generated during lignin depolymerization.
What are the official names of this protein?
Pyranose dehydrogenase, PDH, Pyranose:quinone oxidoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
What are the subcellular locations of this protein?
Secreted.
Protein: MUTS_STRT2
Sequence: MAKEKISPGMQQYLDIKKNYPDAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNADNPIPMAGVPYHSAQAYIDVLVEMGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSANNFLVAIDKVGSRFGLSYMDVSTGEFFATELDDFSSVCSEIQNLKAREVVVGYDLLETDEQVLVNQLNLLLSKETEGYDDVHLIGNSLTDLESSVASKLLQYVHRTQMRELSHLQKAQHYEIKDYLQMSYATKSSLDLLENARTGKKHGSLFWLLDKTKTAMGMRLLRTWIDRPLVNQASIIERQNIIQVFLDNFFERSDLTESLKGVYDIERLASRVSFGKANPKDLIQLGHTLAQVPVIKAILESFNDDALSGLLQELDALPELESLIRSAIDPDAPATITEGGIIRDGFDETLDKYRKVMSEGTSWIADIEAKEREASGITTLKIDYNRKDGYYFHVTNSNLSLVPDHFFRKATLKNSERFGTAELAKIEGEMLEAREKSSTLEYDIFMRVREQVERYIDRLQSLAKAIATVDVLQSLAVTAETNHYVRPVFNDEHRIAIDRGRHAVVEKVMGVQEYIPNTITFDSQTNIQLITGPNMSGKSTYMRQLALSVVMAQMGAYVPADSVDLPVFDAIYTRIGAADDLISGQSTFMVEMMEANQAIKRATPNSLIIFDELGRGTATYDGMALAQSIIEFIHDKVGAKTMFATHYHELTALSNSLTHLVNVHVATLEKDGEVTFLHKIVDGPADKSYGIHVAKIAGLPTDLLNRADTILTQLEGETVVIQPQEKVLSQEKPAIETHVNEQISLFDDFTENPVLQELRDLDIYNMTPMQVMMAVADLKQKL
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: MIF_MACMU
Sequence: MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
What is the function of this protein?
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens.  The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense.  Counteracts the anti-inflammatory activity of glucocorticoids.  Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known.  It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
What are the official names of this protein?
Macrophage migration inhibitory factor, MIF, L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase.
What is the protein family that this protein belongs to?
Belongs to the MIF family.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non- classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Protein: RIBB_ECO5E
Sequence: MNQTLLSSFGTPFERVENALAALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMALTIRHGSGIVCLCITEDRRKQLDLPMMVENNTSAYGTGFTVTIEAAEGVTTGVSAADRITTVRAAIADGAKPSDLNRPGHVFPLRAQAGGVLTRGGHTEATIDLMTLAGFKPAGVLCELTNDDGTMARAPECIEFANKHNMALVTIEDLVAYRQAHERKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: DNAE2_XANAC
Sequence: MSWDDAIDGVDRDTPGGRMPRAWNVAARLRAANDDIVHAQQADGLPAYAELHCLSDFSFLRGASSAEQLFARAQQCGYSALAITDECSLAGIVRGLEASRATGVRLIVGSEFTLVDGTRFVLLVENAHGYPQLCGLITTARRAASKGAYRLDRAEVQAQFRDVAPGVFALWLPGAQPQAEQGAWLQQVFGERAFLAVELHREQDDVARLHVLQALAQQLGMTALASGDVHMAQRRERIVQDTLTAIRHTLPLAECGAHLFRNGERHLRTRRALGNIYPDALLQATVELAQRCTFDISKISYTYPRELVPEGHTPTSYLRQLTEAGIRRRWPGGITAKVREDIEKELALIALKKYEAFFLTVQDVVRFAREQNILCQGRGSSANSAVCYALGITAVNPDETRLLMARFLSEKRDEPPDIDVDFEHERREEVLQYVYSKYGRERAALAATVICYRGKSAVRDVAKAFGLPPDQIALLANCYGWGNGETPMDQRIEEAGFDLANPLINKILAVTEHLRDHPRHLSQHVGGFVISDEPLSLLVPVENAAMANRTIIQWDKDDLETMKLLKVDCLALGMLTCIRKTLDLVRGHRGRNYSIATLPGGDAPTYKMIQRADTVGVFQIESRAQMAMLPRLKPAAFYDLVIEVAIVRPGPIQGDMVHPYLRRRQGREEVNYPSPAVEDILKPTLGVPLFQEQVMELLMHAADYSEDEADNLRRSMAAWRRGGDMEQHRTRVRERMQGKGYASSFIDQIFEQIKGFGSYGFPQSHAASFAKLVYASCWLKRHEPAAFACGLLNAQPMGFYSASQIVQDARRGSPERERVEVLPVDVLHSDWDNTLVGGRPWRSAADPGEQPAIRLGMRQVAGLSQVVAQRIVAARTQRAFADIGDLCLRAALDEKARLALAEAGALQGMVGNRNAARWAMAGVEARCPLLPGSPEERPVEFEAPRAGEEILADYRSVGLSLRQHPMALLRPQMRQRRILGLRELQGRRHGSGVHVAGLVTQRQRPATAKGTIFVTLEDEQGMINVIVWSHLALRRRRALLESRLLAVRGRWERVDGVEHLIAGDLYDLSNLLGDMQLPSRDFH
What is the function of this protein?
DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS).  It is not the major replicative DNA polymerase.
What are the official names of this protein?
Error-prone DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. DnaE2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_XANAC
Sequence: MSKQILILPGDGIGPEIMAEAVKVLKRIDAQHGLGFQLVYDELGGTAYDKYGSPLADETLERARGADAVLLGAVGGPQWDTIDPALRPERGLLKIRSQLGLFANLRPALLYPQLADASTLKPEVVAGLDLLILRELTGGIYFGQPRGNRTLDNGERQAYDTLPYSESEIRRIAKAGFDMARLRGKKLCSVDKANVLASSQLWRAVVEEVAKDYPDIALSHMYVDNAAMQLVRAPKQFDVIVTDNMFGDILSDQASMLTGSIGMLPSASLDANSKGMYEPCHGSAPDIAGKGIANPLATILSVAMMLRYTFARATAADAIEHAVGKVLDQGLRTADIWSEGTTKVGTVAMGDAVVAAL
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_RIPO1
Sequence: MAVPKKKTSKTKRDQRKANWKHQAALEAQKALSLGKSILTGRSTFVYPQDEAEDEDE
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: S35F2_MOUSE
Sequence: MEAESPASAGASEPRALGTVDSIGSQLSRIRRKLFTWDILKTIALGQMLSLCICGTAITSQYLAEKYRVNTPMLQSFINYCLLFLVYTLMLAFQSGSDNLLEILRRKWWKYTLLGLADVEANYLIVRAYQYTTLTSVQLLDCFGIPVLMALSWFILRARYKVIHFIAVFVCLLGVGTMVGADILAGREDNSGSDVLIGDILVLLGASLYAVSNVCEEYIVKKLSRQEFLGMVGLFGTIISGIQLLIVEYKDIARIQWDWKIALLFVAFALCMFCLYSFMPLVIKVTSATSVNLGILTADLYSLFFGLFLFEYKFSGLYILSFTVIMVGFILYCSTPTRTVEPPESSVPPVTSIGIDNLGLKLEESGLPETHSAVL
What is the function of this protein?
Putative solute transporter.
What are the official names of this protein?
Solute carrier family 35 member F2.
What is the protein family that this protein belongs to?
Belongs to the SLC35F solute transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MCRG_METVA
Sequence: MAYKPQFYPGATKVAENRRNHLNPNYELEKLREIPDEDVVKIMGHRQPGEDYKTVHPPLEEMDMPADYVRDLVEPLNGAKEGHRVRYIQFADSMYFAPAQPYDRSRLYMIRLRGVDAGTLSGRQVVECRESDLEEFSKNLLMDTELFDPATSGVRGATVHGHSLRLDENGMMFDALQRCVFDEKTGHVMYVKDQVGKPLDQPVDVGEPMPEAKLREITTIYRKDGIAMRTDPEVIEVVKRIHRARTLGGYIPTNEIFKGL
What is the function of this protein?
Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB).  This is the final step in methanogenesis.
What are the official names of this protein?
Methyl-coenzyme M reductase subunit gamma, Coenzyme-B sulfoethylthiotransferase gamma.
What is the protein family that this protein belongs to?
Belongs to the methyl-coenzyme M reductase gamma subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_RHILO
Sequence: MTISNSVPITPELIAAHGLKPDEYQRILDLVGREPSFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVIQGPGENAGVVDIGDGDCVVFKMESHNHPSFIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGAPDHPKTRHLVAGVVSGVGGYGNSFGVPTVGGEVNFDARYNGNILVNAFAAGLAKTNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDDKIDEKRPTVQVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMSAYEMMLSESQERMLMVLRPEKEKEAEAIFHKWGLDFAIVGKTTDDLRFRVLHQGDQVADLPIKDLGDKAPEYDRPWIEPKKPAPLAANDIPQADVADALLKLLGGPDLSSRRWVWEQYDTLIQGNSLQLPGGDAGVVRVEGHATKALAFSSDVTPRYCEADPYEGGKQAVAECWRNLTATGALPLAATDNLNFGNPERPEIMGQLVGAVKGIGDACRALGFPIVSGNVSLYNETNGQGILPTPTIGGVGLIADWSKMVRTGFAAQDQMILLVGAPASWGTHLGQSVYFRDIHGRTDGPPPPVDLAHEKRVGDHVRSLIASGIVTAAHDVSDGGIAVALAEMAMASGIGATVPGLVGTDPIPVWFGEDQGRYLLTLSIDPHGDEWDAIRKQQGELGIFAPWIGSTGGDALKLGDAKAIPVGDLKAAHEGWFPRFMDQAS
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.