PharMolix/UniProtQA huggingface dataset:
Protein: ANKK1_HUMAN
Sequence: MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPGAEMEI
What are the official names of this protein?
Ankyrin repeat and protein kinase domain-containing protein 1, Protein kinase PKK2, Sugen kinase 288, SgK288, X-kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Protein: PYRF_ECOHS
Sequence: MTLTASSSSRAVTNSPVVVALDYHNRDDALSFVDKIDPRDCRLKVGKEMFTLFGPQFVRELQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAAREALVPFGKDAPLLIAVTVLTSMEASDLVDLGMTLSPADYAERLAALTQKCGLDGVVCSAQEAVRFKQVFGQEFKLVTPGIRPQGSEAGDQRRIMTPEQALSAGVDYMVIGRPVTQSVDPAQTLKAINASLQRSA
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Protein: RS20_CYTH3
Sequence: MANHKSALKRIRANRAKYLRNRYQMKTTRTFVKRLRASTVKADANELYKKVSGMLDKLAKRNIIHKNNAANKKSKLAKFVNKLAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: NADA_SALCH
Sequence: MSVMFDPQAAIYPFPPKPTPLSDDEKQFYREKIKRLLKERNAVMVAHYYTDPEIQQLAEETGGCISDSLEMARFGAKHAASTLLVAGVRFMGETAKILSPEKTILMPTLAAECSLDLGCPIDEFSAFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIEHLDSLGEKIIWAPDRHLGNYVQKQTGADVLCWQGACIVHDEFKTQALTRLKKIYPDAALLVHPESPQSIVEMADAVGSTSQLIKAAKTLPHRQLIVATDRGIFYKMQQAVPEKELLEAPTAGEGATCRSCAHCPWMAMNGLKAIAEGLEQGGAAHEIQVDAALREGALLPLNRMLDFAATLRA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LOLD_GLUOX
Sequence: MNEVSTGASALRLEGLTRRFRSGEETLEILSGAEFELRAGEIVALVAPSGTGKSTLLHLAGLLEAPSAGTVFVADRPASGLSDTVRTAIRRDQIGFVYQFHHLLGEFTACENVMLPQLIAGVSPRKARERARDLLGRFGLSHRLDSLPGRLSGGEQQRTAIARALANQPKLLLADEPTGNLDIGTADHVFGELLRVVREEGAAALIATHNDELASRMDRTVTLRDGKLVPF
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZNUC_VIBCH
Sequence: MAILIELQDICVDFEQRRVLDNIRLTLTKGNITTLIGPNGAGKSTLVKVILGLQSLSSGKIIRQSGIRIGYVPQKLKLNDTLPLTVNRFLKLAGRFSTQELSEALRLVGGEHLQSSDMHKLSGGETQRVLLARALLQRPDLLVLDEPAQGVDVQGQIDLYDLIHTLRNRFGCAVLMVSHDLHLVMAKTDEVICLQHHVCCSGSPESIAKHPSYLAMFGHRSRDTLAFYQHHHEHHHHDLSGLPVKGKASVCSHHSHGHHKHD
What is the function of this protein?
Part of the ABC transporter complex ZnuABC involved in zinc import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Zinc import ATP-binding protein ZnuC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: METK_HAEDU
Sequence: MRLNSMAINLFTSESVSEGHPDKIADQISDAVLDEILKQDPKARVACETYVKTGMALVGGEITTSAWVDIENLTRQVIYDIGYSHSDMGFDAHSCAVLNAIGKQSPDINQGVDREDPLAQGAGDQGIMFGYATNETDVLMPAPITYAHRLMQRQAEVRKSGKLAWLRPDAKSQLTFAYENNQIIGIDAVVLSTQHAEEVKQKELIEGVMEEIIKPTLPSKWLNQHTKYFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGAARHGGGAFSGKDPSKVDRSAAYAARYVAKSIVAAGLADRCEIQLSYAIGVADPTSIMVETFGTGKVSNDTLVKLIYQNFDLRPYGLIKMLDLIQPIYRETAAYGHFGREQFPWERTDKAEALRLAL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROB_DECAR
Sequence: MNPTRLANAKRLVVKVGSALVTNNGTGLDLSAINDWARQIAVLRQQDKEVVLVSSGAIACGMQRLGWAKRPKSVHELQAAAAVGQMGLVQVYEGAFAKHGLHTAQILLTHDDLADRKRYLNARSTLNTLLELGVVPIINENDTVVTDEIKFGDNDTLGALVANLIEADALIILTDQQGLYTADPRKDPSATLINEATAGDETLEGMAGGAGTRIGTGGMITKVIAAKRAARSGAHTAIASGRETDPIIRLANGEPVGTLLVSQTQPLAARKQWLADHLQLAGRLILDAGAVNALHAGKSLLPIGVIAAEGEFERGAAVACISPDGREIARGLSNYGSGEARLIARKTTQEIENTLGYVDEPEIIHRDNLILS
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RODZ_SALSV
Sequence: MNTEATHDQNEAQTTGVRLRNAREQLGLSQQAVAERLCLKVSTVRDIEEDKAPSDLASTFLRGYIRSYARLVHVPEEELLPGLEKQAPLRAAKVAPMQSFSLGKRRKKRDGWLMSFTWLVLFVVVGLTGAWWWQNHKAQQEEITTMADQSTAELNADKDSGQNVPLDTRDATSQDTTPAQTAPAPATPVDSTAATQTPAATATATQNTVVAPSQANVDTAATSAAPAATETPSALPTSQAGVAAPAADPNALVMNFTADCWLEVTDATGKKLFSGMQRKDGNLNLTGQAPYKLKIGAPAAVQIQYQGKPVDLSRFIRTNQVARLTLNAEPTPAQ
What is the function of this protein?
Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
What are the official names of this protein?
Cytoskeleton protein RodZ.
What is the protein family that this protein belongs to?
Belongs to the RodZ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Forms helical filaments along the long axis of the cell.
Protein: PDXH_CITK8
Sequence: MSDNDELQQIAHLRREYTRGGLRRNDLPAEPLTLFERWLGQACDARLADPTAMVVATVDENGQPYQRIVLLKHYDEKGMVFYTNLGSRKAHHLENNPRISLLFPWHMLERQVMVTGKAERLSTLEVVKYFHSRPRDSQIGAWVSKQSSRISARGILESKFLELKQKFQQGEVPLPSFWGGFRVNIEQMEFWQGGEHRLHDRFLYQRENNAWKIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RPOD_XANCP
Sequence: MANERPAQQSDIKLLISKGLEQGYLTYAEVNDHLPDDLVDPEQIEDIISMINGMGIDVHEVAPDAETLLLNDGNTGNREVDDTAAEEAAAALTALDTEGGRTTDPVRMYMREMGTVELLTREGEIAIAKRIEEGLSQVQAALGTFPLSTELLLSDYEAHKEGKKRLAEIVVGFNDLIEEADAAAAALAAAGPVAVDEDAVDEDADEDGDDDAAEEEAGPTGPDPVEVATRMENLANEYAKFKKAYVKYGAEHKNVAKAREDMAAIFTTLKLPLPLTDALVTQLRGVVNGIKDHERKVLHLATTVARMPRKDFIRSWEGNQTNLEWVEDALKRKQKWSSALRDVKDQIVSEQQGSIEMEKANYLTLAEIKDISRAMAYGEAKARKAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQQFGREATPEELAKEMDMPEDKIRKVMKIAKEPISMETPIGDDEDSHLGDFIEDTNVESPIDNTTNINLSETVRDVLAGLTPREAKVLRMRFGIDMNTDHTLEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEQLRSFLDID
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor RpoD, Sigma-70.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TT30A_XENLA
Sequence: MAVRQIKDGEYTATIYRLIKEARYGEAIQVLSNELQKQYRSRAGLSLLGYCYYQIQDFVNAADCYEQLIQISPEVEEYKLYYAQSLYKACMYPEAMKATFALDNAAYQSKMLKLQASVKYGEEDISGAKSLVEQMPSEDPESEINMGCLLYKEGHYEEACKKFITAMQVMGYKQDLSFNIALCYYSMKQYAPALKHIADIIERGIREHPELGVGMTTEGIEVRSVGNTLVLHETALIEAFNLKAAIEYQLKNYEAAQEALTDMPPRSEEELDPVTLHNQALMNMDTKPTEGFEKLQFLLQQNPFPPETFGNLLLLYSKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFLKLDELAGMLTEQMRKLTKQVQEARHNRDDEAVKKAVNEYDETLEKYIPVLMAQAKIYWNMENYQMVEKIFRKSVEFCNEHDIWKLNVAHVLFMQDNKYKEAIGFYEPIVKKHYDNILNVSAAVLANLCVSYIMTSQNEEAEELMRKIEKEEEQIAYENPDKKIYHLCIVNLVIGTLYCAKGNYEFGISRVIKSLEPYNKKLGTDTWYHAKRCFLSLLENMSKHMIMLRDDVIVECIQFLEHCEIYGRNILAVIEQPLEEERMHIGKNTVTYESRQLKALLYEITSWNL
What is the function of this protein?
Required for polyglutamylation of axonemal tubulin.  Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
What are the official names of this protein?
Tetratricopeptide repeat protein 30A, TPR repeat protein 30A.
What is the protein family that this protein belongs to?
Belongs to the TTC30/dfy-1/fleer family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: KGUA_FUSNN
Sequence: MSLGALYVVSGPSGAGKSTVCKLVRERLGINLSISATSRKPRNGEQEGVDYFFITAEEFERKIKNDDFLEYANVHGNYYGTLKSEVEERLKRGEKVLLEIDVQGGVQVKNKFPEANLIFFKTANKEELEKRLRGRNTDSEEVIQARLKNSLKELEYESKYDRVIINNEIEQACNDLISIIENGVK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRTB_MYCTU
Sequence: MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALASSVTCGPAHGPLPADLGSHPSH
What is the function of this protein?
Involved in the biosynthesis of carotenoids.  Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity).
What are the official names of this protein?
Phytoene synthase, PSase.
What is the protein family that this protein belongs to?
Belongs to the phytoene/squalene synthase family.
Protein: KLRD1_PANTR
Sequence: MAVFKTTLWRLISGTLGIICLSLMATLGILLKNSFTKLSIEPAFTPGPNIELQKDSDCCSCQEKWVGYRCNCYFISSEQKTWNESRHLCASQKSSLLQLQNTDELDFMSSSQQFYWIGLSYSEEHTAWLWENGSALSQYLFPSFETFNPKNCIAYNPNGNALDESCEDKNRYICKQQLI
What is the function of this protein?
KLRD1-KLRC2 acts as an immune activating receptor.  On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy.  Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection.  Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
What are the official names of this protein?
Natural killer cells antigen CD94, Killer cell lectin-like receptor subfamily D member 1, NK cell receptor.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: INT3_DROVI
Sequence: MEQQQQKSAAHVSKLFVCTAVDCKDEIEEKFERSYVSLQQQIAGLSDKEMHDMLTQIVCKEKQHEEISIGFLYIILTDPAMAPKTYRDITLVSRDGMNVIVANLTLLVAEKYAKLTETARRQLIWVLREFVKHQVLSVENVIWNCLRQAGGGDVSHKNLFLVESLLDIFIEYRAWLEAIPFLVQSSVYSFVRLIEDHANPALMPLRQKEVKFTISLIRDRFQDIIPLGRDFVRLLQNVARIPEFELLWRDILCNPKSLHPTFNGIWHLLQIRTSRRFLQCRLLPEMERKLHFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHPTNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIRNHPFVSSTLLDFLCRITKNFYIKNEDKIRLGVYNSLKLILDKQVIPNLHPLFESPKLDRELRNLIRENFREFVSPVANMPQSIYPATHSIQAPIFKKEADQRMLQSENIDVGSGAFAANSGTISLVDDDNKIAITPVESSERETEAVFSDDDGENIARCNKNDENTDDDDDLPLSKVRLKEKPVPEKVELPDAIAESFEIFVTKRNSFTWEAFLKDFRTLPASTLDETQLNYVISNTVLILRETLPQQNVFSESKTEEKYLAKSISYPLYGLFRFLYENEDKSKKPFQTLLSEICERLSETGYLLLYFMKIHCKLQTRKNAQQSYQFKTTVYRQICEATDEKIGICLVRDLDLLEKENTTIYLWLLPDIYREFKTIAINNTDLLRITLRCVDAKNVRDIMYSIAQGKLTIFKQDGLIDCIRESLEYETYEQFCLWQLIQAHDVPLKCIQDILPELEAANHPEALSHLLLLLKNEEPTSEIIRLLLSREAKTRGDPFVTSALRFWCQRCEEKLSEIIASLLTSKYPSSSPNKRKRPSKGSSAASSTPSADHVLNHLEHYRRSCRHGTGTGLYVHDMMQRALQSAYSHSNESTKKQFSDLFALAAEDETTAVGRRGGSGRGRKQPVGKKDSNNHNAGSKKNSDVVKTIYSSDENSSEEDWSKHKITQAAKKRKKAINDSD
What are the official names of this protein?
Integrator complex subunit 3 homolog, SOSS complex subunit A homolog.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 3 family.
Protein: KYNU_LODEL
Sequence: MSSDKAKAFDAQFPTYKSEFQIPTFESLGIQNSKYSPETNSIYLCGNSLGLMPRNTTELINRELQAWSSRGVEAHFNHSHPQGTDWVDIDLPLLPLLAPLVGAKQNEVAVMGSLTSNLNALLIHFYKPKGKRTKILFEKQAFPSDYYAFLNIVQVFGYDASHLIQIEIPKGETYIKTETILDVFDKYEDEIAIVCLPGIQYYTGQFFDIAKITKHVKTSAPDVVVGWDLAHAVGNVPLSLHDWGVDFAAWCSYKYLNAGPGAIAGIFVNEKYTEQNKPENYKPRLAGWWGNNSSQRFQMLEKFDPIASALSYRQLNPSVLDCVALKSSLEIFNKVGGMLSLRDKSLAMTQFLQDILTKSNYYIEQGETDVNKFGFKIITPLDPNQRGCQLSLLFQPHRDEKKQNVMERVFEYLHQHAIICDERRPDVIRLAPLPLYNTFEETRIGATRLLEALEAIKDDYI
What is the function of this protein?
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
What are the official names of this protein?
Kynureninase, Biosynthesis of nicotinic acid protein 5, L-kynurenine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the kynureninase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLK_ECOSE
Sequence: MTKYALVGDVGGTNARLALCDIASGEISQAKTYSGLDYPSLEAVIRVYLEEHKVEVKDGCIAIACPITGDWVAMTNHTWAFSIAEMKKNLGFSHLEIINDFTAVSMAIPMLKKEHLIQFGGAEPVEGKPIAVYGAGTGLGVAHLVHVDKRWVSLPGEGGHVDFAPNSEEEAIILEILRAEIGHVSAERVLSGPGLVNLYRAIVKADNRLPENLKPKDITERALADSCTDCRRALSLFCVIMGRFGGNLALNLGTFGGVFIAGGIVPRFLEFFKASGFRAAFEDKGRFKEYVHDIPVYLIVHDNPGLLGSGAHLRQTLGHIL
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLDX1_MOUSE
Sequence: MRAQLWLLQLLLLRGAARALSPATPAGHNEGQDSAWTAKRTRQGWSRRPRESPAQVLKPGKTQLSQDLGGGSLAIDTLPDNRTRVVEDNHNYYVSRVYGPGEKQSQDLWVDLAVANRSHVKIHRILSSSHRQASRVVLSFDFPFYGHPLRQITIATGGFIFMGDMLHRMLTATQYVAPLMANFNPGYSDNSTVAYFDNGTVFVVQWDHVYLQDREDRGSFTFQAALHRDGRIVFGYKEIPMAVLDISSAQHPVKAGLSDAFMILNSSPEVPASQRRTIFEYHRVELDSSKITTTSAVEFTPLPTCLQHQSCDTCVSSNLTFNCSWCHVLQRCSSGFDRYRQEWLTYGCAQEAEGKTCEDFQDDSHYSASPDSSFSPFNGDSTTSSSLFIDSLTTEDDTKLNPYAEGDGLPDHSSPKSKGPPVHLGTIVGIVLAVLLVAAIILAGIYISGHPNSNAALFFIERRPHHWPAMKFHNHPNHSTYTEVEPSGHEKEGFVEAEQC
What is the function of this protein?
Plays a critical role in endothelial cell capillary morphogenesis.
What are the official names of this protein?
Plexin domain-containing protein 1, Tumor endothelial marker 7.
What is the protein family that this protein belongs to?
Belongs to the plexin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.
Protein: PEX10_HUMAN
Sequence: MAPAAASPPEVIRAAQKDEYYRGGLRSAAGGALHSLAGARKWLEWRKEVELLSDVAYFGLTTLAGYQTLGEEYVSIIQVDPSRIHVPSSLRRGVLVTLHAVLPYLLDKALLPLEQELQADPDSGRPLQGSLGPGGRGCSGARRWMRHHTATLTEQQRRALLRAVFVLRQGLACLQRLHVAWFYIHGVFYHLAKRLTGITYLRVRSLPGEDLRARVSYRLLGVISLLHLVLSMGLQLYGFRQRQRARKEWRLHRGLSHRRASLEERAVSRNPLCTLCLEERRHPTATPCGHLFCWECITAWCSSKAECPLCREKFPPQKLIYLRHYR
What is the function of this protein?
E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292).  The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity).  PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:24662292).  When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity).
What are the official names of this protein?
Peroxisome biogenesis factor 10, Peroxin-10, Peroxisomal biogenesis factor 10, Peroxisome assembly protein 10, RING finger protein 69.
What is the protein family that this protein belongs to?
Belongs to the pex2/pex10/pex12 family.
Protein: METAA_STRP2
Sequence: MPIRIDKKLPAVEILRTENIFVMDDQRAAHQDIRPLKILILNLMPQKMVTETQLLRHLANTPLQLDIDFLYMESHRSKTTRSEHMETFYKTFPEVKDEYFDGMIITGAPVEHLPFEEVDYWEEFRQMLEWSKTHVYSTLHICWGAQAGLYLRYGVEKYQMDSKLSGIYPQDTLKEGHLLFRGFDDSYVSPHSRHTEISKEEVLNKTNLEILSEGPQVGVSILASRDLREIYSFGHLEYDRDTLAKEYFRDRDAGFDPHIPENYFKDDDVNQVPCLCWSSSAALFFSNWVNHAVYQETPFDWRKIEDDASAYGYL
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_COLP3
Sequence: MSDVSGKVNLLNFDHKSMREYLESIGEKPFRADQIMKWIYHFGYSDFEQMTNINKKLREKLQRNCIISAPDISEKQVSEDGTIKYALKLEGGQEVETVWIPENDRATLCVSSQVGCALECTFCATAQQGFNRNLSMAEIIGQVWRVANDIGATRIAGTRPITNIVMMGMGEPLLNMKNLIPALDTMLNDLGYGLSKRRVTVSTSGVVPALDMLKAKIDCALAISIHAPNNKLRDELVPINKKYPLEDFIAAAGRYIEGSKANKQATIEYVMLDHVNDSTDQAHELAHALKGLPSKINLIPFNPYPGSPYSRSSNSRIDRFDKVLQSYGLTVITRRTRGEDIDAACGQLAGDVFDRTKRSVINAAKNAEISSLKNQPKADTISIKVV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YMEL1_MOUSE
Sequence: MFSLSSTVQPQVTIPLSHLINAFHSPKNISVSVNTPVSQKQHRDTVPEHEAPSSEPVLNLRDLGLSELKIGQIDKMVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLRSICSDLQYFPVFIQSRGFKTLKSRTRRLQSTSERLVEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR
What is the function of this protein?
ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity).  Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure (PubMed:17709429, PubMed:24616225, PubMed:26785494, PubMed:27495975).  Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (By similarity).  Required for normal, constitutive degradation of PRELID1 (PubMed:26785494).  Catalyzes the degradation of OMA1 in response to membrane depolarization.  Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (By similarity).
What are the official names of this protein?
ATP-dependent zinc metalloprotease YME1L1, ATP-dependent metalloprotease FtsH1, YME1-like protein 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Mitochondrion.
Protein: KIF2C_MACFA
Sequence: MIDFDDVAAINPELLQLLPLHPKDNLPLQENVTIQKQKRRSVNSKIPAPKESLRTRSTRMSTVSELRVTAQENDMEVELPAAANTRKQFSVPPTHPRPSCPAVAEIPSRMVSEEVEEQVHSIRGSSSANPVNSVRRKSCIVKEVEKMKNKREEKKAQNSEMRMKRAQEYDSSFPNWEFARMIKEFRATLECHPLTMTDPIEEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASRDVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGKQQVQVVGLQEHLVNSADDVIKMIDMGSACRTSGQTFANSNSSRSHACFQILLRAKGRMHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQLIQMETEEMEACSNGALIPGNLSKEEEELSSQMSSFNEAMTQIRELEERAVEELKEIIQQGPDWLELSEMTEQPDYDLETFVNKAEFALAQQAKHFSALRDVIKALRLAMQLEEQASRQISSKKRPQ
What is the function of this protein?
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells.  Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.  Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.
What are the official names of this protein?
Kinesin-like protein KIF2C, Mitotic centromere-associated kinesin, MCAK.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1. Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.