PharMolix/UniProtQA huggingface dataset:
Protein: MTNN_STAA1
Sequence: MIGIIGAMEEEVTILKNKLTQLSEISVAHVKFYTGILKDREVVITQSGIGKVNAAISTTLLINKFKPDVIINTGSAGALDESLNVGDVLISDDVKYHDADATAFGYEYGQIPQMPVAFQSSKPLIEKVSQVVQQQQLTAKVGLIVSGDSFIGSVEQRQKIKKAFPNAMAVEMEATAIAQTCYQFNVPFVVVRAVSDLANGEAEMSFEAFLEKAAVSSSQTVEALVSQL
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: MNTH_SALPC
Sequence: MTDNRVENSSGRAARKLRLALMGPAFIAAIGYIDPGNFATNIQAGASFGYQLLWVVVWANLMAMLIQILSAKLGIATGKNLAEQIRDHYPRPVVWFYWVQAEIIAMATDLAEFIGAAIGFKLILGVSLLQGAVLTGIATFLILMLQRRGQKPLEKVIGGLLLFVAAAYIVELFFSQPDMAQLGKGMVIPALPNPEAVFLAAGVLGATIMPHVIYLHSSLTQHLHGGTRQQRYSATKWDVAIAMTIAGFVNLAMMATAAAAFHFSGHTGIADLDQAYLTLEPLLSHAAATVFGLSLVAAGLSSTVVGTLAGQVVMQGFVRFHIPLWVRRTITMLPSFIVILMGLDPTRILVMSQVLLSFGIALALVPLLIFTSNATLMGELVNTRRVKQVGWIIVVLVVALNIWLLVGTVMGLS
What is the function of this protein?
H(+)-stimulated, divalent metal cation uptake system.
What are the official names of this protein?
Divalent metal cation transporter MntH.
What is the protein family that this protein belongs to?
Belongs to the NRAMP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DAPE_ACTP7
Sequence: MKHNIINLAQDLIRRPSVSPDDQGCQQVIAERLAQLGFTLEWLPFGDTLNLWATHGTQDPCVVFAGHTDVVPVGDETQWQYPPFSAEIVDGTLYGRGAADMKGSLAALVIAAETFVKNNPNHKGKIALLITSDEEAAAKAGTVKVVETLMARQEAVHYAVVGEPSSGKVLGDVIKNGRRGSITGELYIEGVQGHVAYPHLAENPVHTSLNFLTELTTYQWDNGNEFFPPTSLQIANIKAGTGSNNVIPGELYVQFNLRYCTEVTDEIIKNKVAEMLAKHQLKHRISWNLSGQPFLAGNGELVKATVQAVENVTKITPRLDTSGGTSDGRFIALMGAEVVEFGPLNATIHKVNECVSVEDLGKCGEVYYHILERLLKS
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: BCPA_CHLTE
Sequence: MALFGSNDVTTAHSDYEIVLEGGSSSWGKVKARAKVNAPPASPLLPADCDVKLNVKPLDPAKGFVRISAVFESIVDSTKNKLTIEADIANETKERRISVGEGMVSVGDFSHTFSFEGSVVNLFYYRSDAVRRNVPNPIYMQGRQFHDILMKVPLDNNDLIDTWEGTVKAIGSTGAFNDWIRDFWFIGPAFTALNEGGQRISRIEVNGLNTESGPKGPVGVSRWRFSHGGSGMVDSISRWAELFPSDKLNRPAQVEAGFRSDSQGIEVKVDGEFPGVSVDAGGGLRRILNHPLIPLVHHGMVGKFNNFNVDAQLKVVLPKGYKIRYAAPQYRSQNLEEYRWSGGAYARWVEHVCKGGVGQFEILYAQ
What is the function of this protein?
Intermediary in the transfer of excitation energy from the chlorophyll to the reaction centers.
What are the official names of this protein?
Bacteriochlorophyll a protein, BCP, BChl a protein, Fenna-Matthews-Olson protein, FMO protein.
Protein: RS16_SYNRU
Sequence: MAAVESVQCFGRKKTAVAVTYCRRGRGLIRLTVPIELVEPEILRYKAFEPVLLLGRSKFAGVDMRIRVKGGGNTSQIYAIRQSIAKALVAYFQKYVDEQSKKEIKDVLLRYDRTLLVADPRRCEPKKFGGRGARSRFQKSYR
What are the official names of this protein?
40S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C7192_ESCCA
Sequence: MEEMKILMMNNPWILTATATTLLISIFLFFTRKSSKMVWPAGPKTLPIIGNMHLLGGTALQVVLHNLAKVHGSVMTIWIGSWRPVIVVSDIERAWEVLVNKSSDYSARDMPDITKIISADWKTISTSDSGPHWTNLRKGLQNVALSPHNLAAQFQFQEKDMTKMIQTLEEEARNNNGIVKPLDHMKKATLRLISRLVFGQDFNNDKYVDDMHLAIEELIRVSGYARLAEAFYYAKYLPSHKKAVREVEEAQRRVQNLVSPFLSLNPPTNTYLHFLRSQKYDDEVIIFAIFEAYLLGVDSTSLTTAWALAFLIREPNVQEKLYQELESFASKNDRRILKVEDINKLQYLQAVIKETMRMKPIAPLAIPHKACRDTSLMGKKIDKGTRVMVNIFALHHNKNVFNDPFKFMPERFMKVDSQDANGKAMEQSLLPFSAGMRICAGMELGKLQFSFALANLAYAFKWSCVADGVLPDMSDQLGFVLLMKTPLEARINRRN
What is the function of this protein?
Methylenedioxy bridge-forming cytochrome P450 involved in the biosynthesis of isoquinoline alkaloids.  Converts (R,S)-cheilanthifoline to (S)-stylopine with a high substrate specificity.  Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
What are the official names of this protein?
(S)-stylopine synthase 1, STS, Cytochrome P450 719A2, EcCYP719A2, EcCYPB.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: SERC_STRT1
Sequence: MTIYNFSAGPATLPKPVLEKAQAELLNYQDSGMSVLEMSHRSPEFDKIIKDAEATLRELMAIPDNYKVIFLQGGASTQFTMVPLNLAQGKKAYYLVGGSWGKKAYTEAVKLSKTIPFEPILLASSEDTVYDHIPSFDPSTIDPEAAYVHLTTNNTIEGTSIYDLPDTNGVPIVADMSSNILAARYNVEDFALIYAGAQKNIGPAGVTVVIVREDFLNDQPQLSAMLDYRIQAEAGSLYNTPPCFNIYISKLVFDWVKNEIGGVDKMAEIQREKSGLLYDYIESSDFYTNPVKDAKDRSVCNIPFVTPSKDLDAKFVAEADALGFKNIKGHRSVGGMRASVYNAFPRQGVLDLIDFMKKFEDENK
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_EHRRW
Sequence: MINVSFLGLMSGISVLLKTTVIVVGIFEGSNHLEDNGALEGYNDKIMEIVNGYQSFDGKFAEVLPIIGLEKDFPVVVVIGLGKSEDFDENKALKVGGVIYSELNRMKIPDASIVINTDSNVSANIGYGALLRSFKFDKYFVEKKDKNSVYLNKLVLFSKSEPQEVTALFNDLKAEGESIFLARSFVSEPPNILYPETYAQMIYEELSKVGVTVEVFDEDYMKANQMMALLGVGQGSAKKSRLVVMKWNGGDESESPIAFVGKGVTFDTGGISLKPSKGMWDMKYDMAGSASVVGIMRTLAARKAKVNAVGVVGLVENSVDGNAQRPSDVVISMSGQTIEVLNTDAEGRLVLADALWYTQEMFTPKLMVDLATLTGAVVVALGNNQYAGLFSNDDAIANQLIVAGNESGEKLWRLPLDEAYDKLIDSSIADMQNISTKGYGADSITAAQFLQRFVNGVPWVHLDIAGMAWDYEGTEICPKGATGFGVRLLNRFVSKYYESH
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFA_YERPN
Sequence: MALTKAEMSEHLFEKLGLSKRDAKDLVELFFEEVRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVESATPKE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: TRMB_SYNE7
Sequence: MARVRVRQHVNPLSQKFQVVTTWPDWQQVYADCDRPLHLDIGCARGRFLLAMATAQPEWNYLGLEIREPLVDEANAIARERELTNLYYHFSNANLDLEPLLRSLPTGILQRVSIQFPDPWFKKRHQKRRVVQPELVQALATALPAGAEVFLQSDVLEVQAEMCEHFAAEPRFQRTCLDWLPENPLPVPTEREIAVQNKQLPVYRALFIRQPAD
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: AROB_FUSNN
Sequence: MKKIFDDIYVGSNIISKLNDYTEDFDKILIFSNETIADLYFEKFKSTLNEKDKVFYFAIKDGEEYKNIESILPVYDFMLENNFSRKSLIISLGGGVICDMGGYISATYMRGIEFIQVPTSLLAQVDASVGGKVAINHPKCKNMIGSFKNPYRVIIDVEFLKTLPKREFKSGMGELLKHSFLTKDKSYLEYIENNVEKIKNLDNEVLENIVEQSIRIKKHYVDIDPFEKGERAFLNLGHTYAHALESFFDYKAYTHGEAVSKGIIFDLELSLLRGQIDKEYLERARNIFKLFDIDTDLIYLPSDKFIPLMRKDKKNSFNKIITILLDSEGHLSKTEVKEDEIVKIIDKYKNNFLRASIDIGTNSCRLLIAEVEKDNENITFKKEIYKDLEIVKLGEDVNKNKFLKEEAIERTLKCLKKYRKIIDKYSIEEKNIICFATSATRDSTNKDYFIKKVFDETKIKINCISGDKEAYINFKGVISSFDRDFKDNILVFDIGGGSTEFTLGNMQGIEKKISLNIGSVRITEKFFLNNKLYNYSEENRIKAKDWVKENLKELEDFKKLNFSLIGVAGTTTTQVSVREKMEVYDSEKIHLSNLTSKEINDNLSLFIKNINKQEIKGLDPKRKDVIIGGTIILKEILDYFGKDFIIVSENDNLMGAILEGVENK
What are the official names of this protein?
Bifunctional 3-dehydroquinate synthase/phosphatase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GppA/Ppx family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGA_ECO27
Sequence: MQVLHVCSEMFPLLKTGGLADVIGALPAAQIADGVDARVLLPAFPDIRRGVTDAQVVSRRDTFAGHITLLFGHYNGVGIYLIDAPHLYDRPGSPYHDTNLFAYTDNVLRFALLGWVGAEMASGLDPFWRPDVVHAHDWHAGLAPAYLAARGRPAKSVFTVHNLAYQGMFYAHHMNDIQLPWSFFNIHGLEFNGQISFLKAGLYYADHITAVSPTYAREITEPQFAYGMEGLLQQRHREGRLSGVLNGVDEKIWSPETDLLLASRYTRDTLEDKAENKRQLQIAMGLKVDDKVPLFAVVSRLTSQKGLDLVLEALPGLLEQGGQLALLGAGDPVLQEGFLAAAAEYPGQVGVQIGYHEAFSHRIMGGADVILVPSRFEPCGLTQLYGLKYGTLPLVRRTGGLADTVSDCSLENLADGVASGFVFEDSNAWSLLRAIRRAFVLWSRPSLWRFVQRQAMAMDFSWQVAAKSYRELYYRLK
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: RS19E_HALMA
Sequence: MATLYDVPPEELIEALTETLADEDDIEAPDWAEFTKTGVDRELPPEQEDFWTRRAASLLRKVAVDGPVGVNALRSEYGTSKQGTTRYRVRPHQKTKGSGNIIRTALQQLEDAGYVETSENDGRRVTGDGRSLLDDTAGDLLTELDRPELERYA
What is the function of this protein?
May be involved in maturation of the 30S ribosomal subunit.
What are the official names of this protein?
30S ribosomal protein S19e, E1.3, HS12.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS19 family.
Protein: AQP8_RAT
Sequence: MSGEQTPMCSMDLREIKGKETNMADSYHGMSWYEQYIQPCVVELLGSALFIFIGCLSVIENSPNTGLLQPALAHGLALGLIIATLGNISGGHFNPAVSLAVTLVGGLKTMLLIPYWVSQLFGGMIGAALAKVVSPEERFWNASGAAFAIVQEQEQVAEALGVEIVMTMLLVLAVCMGAVNEKTMGPLAPFSIGFSVIVDILAGGGISGACMNPARAFGPAVMAGYWDFHWIYWLGPLLAGLFVGLLIRLFIGDEKTRLILKSR
What is the function of this protein?
Channel that allows the facilitated permeation of water and uncharged molecules, such as hydrogen peroxide and the neutral form of ammonia (NH3), through cellular membranes such as plasma membrane, inner mitochondrial membrane and endoplasmic reticulum membrane of several tissues (PubMed:15988592, PubMed:9299432, PubMed:9374520, PubMed:31372390, PubMed:33892285, PubMed:12774023, PubMed:15948717, PubMed:16177191, PubMed:16624991, PubMed:17189259, PubMed:18059526, PubMed:20132793, PubMed:23299935, PubMed:15749715).  The transport of ammonia neutral form induces a parallel transport of proton, at alkaline pH when the concentration of ammonia is high (PubMed:15988592).  However, it is unclear whether the transport of proton takes place via the aquaporin or via an endogenous pathway (PubMed:15988592).  Also, may transport ammonia analogs such as formamide and methylamine, a transport favourited at basic pH due to the increase of unprotonated (neutral) form, which is expected to favor diffusion (PubMed:15988592, PubMed:15749715, PubMed:15948717).  Does not transport urea or glycerol (PubMed:15948717).  The water transport mechanism is mercury- and copper-sensitive and passive in response to osmotic driving forces (PubMed:9374520, PubMed:9299432, PubMed:18059526, PubMed:20132793).  At the canicular plasma membrane, mediates the osmotic transport of water toward the bile canaliculus and facilitates the cAMP-induced bile canalicular water secretion, a process involved in bile formation (By similarity).  In addition, mediates the hydrogen peroxide release from hepatocyte mitochondria that modulates the SREBF2-mediated cholesterol synthesis and facilitates the mitochondrial ammonia uptake which is metabolized into urea, mainly under glucagon stimulation (PubMed:23299935, PubMed:20132793, PubMed:31372390).  In B cells, transports the CYBB-generated hydrogen peroxide from the external leaflet of the plasma membrane to the cytosol to promote B cell activation and differentiation for signal amplification (By similarity).  In the small intestine and colon system, mediates water transport through mitochondria and apical membrane of epithelial cells (PubMed:15749715, PubMed:18059526, PubMed:16177191).  May play an important role in the adaptive response of proximal tubule cells to acidosis possibly facilitating mitochondrial ammonia transport (By similarity).
What are the official names of this protein?
Aquaporin-8, AQP-8.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATPB_RICAH
Sequence: MTKNIGKITQIISAVVDVKFTNNGELPEILNALECYNDKQRIVLEVAQHIGDDTVRCIAMDSTEGLVRGVEVMDTGSPICIPVGTETLGRIMNVVGEPIDGKGDIKSSNISAIYKSAPDFTNQSTERNILVTGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYTVFAGVGERTREGNDLYHEMIDSGVIDLEKPENSKVALVYGQMNAPPGARARVALSGLTIAESFRDMNGGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGELQERITSTKHGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLSRQIAEFGIYPAVDPLDSNSQVLDPMIVGEEHYSVARQVQQVLQTYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFHVAEVFTGSEGKFVNLADTIAGFKGLVEGKYDDLPEAAFYMVGTIDEAIEKAKILK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PANB_PSE14
Sequence: MPNITVTSLLAMKQKGEKITMLTCYDATFAHTASQAGVEVLLIGDSLGMVLQGHDSTLPVTTAETAYHVACVKRGNQGAMILADLPFMANATLEQTFINSATLMQAGAHMIKVEGAAWLGESIRLLAERGIPVCAHMGLTPQAVNVLGGYKVQGRLEAQARQMRADAIALEQAGAAMILLECVPSELAEEITQAVKIPVIGIGAGSATDGQVLVLHDMLGLSISGRVPKFVKNFMTGQPDIQSAIRAYVAAVKDVSFPATEHGFSA
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOXH1_HUMAN
Sequence: MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL
What is the function of this protein?
Transcriptional activator.  Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'.  Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling.  Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
What are the official names of this protein?
Forkhead box protein H1, Forkhead activin signal transducer 1, Fast-1, hFAST-1, Forkhead activin signal transducer 2, Fast-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: ASNA_ECOLI
Sequence: MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGCEKAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHSVYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPFLPDQIHFVHSQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGHAGLNGDILVWNPVLEDAFELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQCGVWPAAVRESVPSLL
What is the function of this protein?
May amidate Asp of the extracellular death factor precursor Asn-Asn-Trp-Asp-Asn to generate Asn-Asn-Trp-Asn-Asn.
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMS4_YEAST
Sequence: MSQIVDFVEDKDSRNDASIQIIDGPSNVEIIALSESMDQDECKRAHVSSAEMIPSSPQRKSVSNDVENVDLNKSIELSAPFFQDISISKLDDFSTTVNSIIDSSLRNENNAKGNAKKLLDDLISDEWSADLESSGKKHNKSQYNLRDIAEKWGVQSLKNPEPIAVDCEYKTQGIGKTNSDISDSPKSQIGAADILFDFPLSPVKHENPTEEKHNSIANENSSPDNSLKPAGKQNHGEDGTSMAKRVYNKGEDEQEHLPKGKKRTIALSRTLINSTKLPDTVELNLSKFLDSSDSITTDVLSTPAKGSNIVRTGSQPIFSNANCFQEAKRSKTLTAEDPKCTKNTAREVSQLENYIAYGQYYTREDSKNKIRHLLKENKNAFKRVNQIYRDNIKARSQMIIEFSPSLLQLFKKGDSDLQQQLAPAVVQSSYNDSMPLLRFLRKCDSIYDFSNDFYYPCDPKIVEENVLILYYDAQEFFEQYTSQKKELYRKIRFFSKNGKHVILILSDINKLKRAIFQLENEKYKARVEQRLSGTEEALRPRSKKSSQVGKLGIKKFDLEQRLRFIDREWHVKIHTVNSHMEFINSLPNLVSLIGKQRMDPAIRYMKYAHLNVKSAQDSTETLKKTFHQIGRMPEMKANNVVSLYPSFQSLLEDIEKGRLQSDNEGKYLMTEAVEKRLYKLFTCTDPNDTIE
What is the function of this protein?
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick.  Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions.  Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures.  May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV.  May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).  This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover.  In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved.  Spore formation and viability are severely impaired in deletion strains.
What are the official names of this protein?
Crossover junction endonuclease MMS4.
What is the protein family that this protein belongs to?
Belongs to the EME1/MMS4 family.
Protein: PNP3_ALKMQ
Sequence: MVKTFEMKLGGRPFVVEIGKVAELAQGSCMIKYGDTTVLVTACASKEPKEGLDFFPLSCDYEEKLYAVGKIPGGFIKRESRPSEKATLTARLIDRPIRPLFPKGYHNDVQVIATVLSMDQDCPPDISAMIGSSIALSVSNIPFMGPTASVSVGMIDGEYIVNPTSKQKEDSTLELIVSGTKNAIMMIEAGANELTEAQILDAIMFAHEEIKKIVAFIENIVSEVGKPKSEVIAKQMDSNLLTEVVIFLDTKLANAIKTFDKTERNENIQAVSAEALDYFEEKYEGRSKEVHDILSMLIKVETRKMITSEGIRPDNRKLDEIRPISTQVGILPRAHGTGLFNRGETQVLTITTLGDLRDAQRIDGIGEEDEKRYMHHYNFPPYSVGETRFMRGPSRREIGHGALVERALLPMIPSKEDFPYAIRLVSEVLTCNGSSSQASVCGSTLSLMDAGVPIKRMVAGIAMGLIKEDDQVVILSDIQGMEDALGDMDLKVAGTEEGITAMQMDIKIAGIDRGIMETALEQARIGRLHILNKMKESITSPRIELSSYAPKVTQIKVHPDKVREVIGAGGKVINKIIDETGCKITIENDGTIYVAAPDQESSRRAVEMIELIVKDPVVGEVYTGKVIKIMDFGAFVEILPGKEGLVHISNLAHERVTKVTDVLAEGDLIEVKLMEINPQGKIGLSRKALLPKPETKSETQSE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase 3, Polynucleotide phosphorylase 3, PNPase 3.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_BURCH
Sequence: MSMSDPIADMLTRIRNAQMVEKVSVAMPSSKVKVAIAQVLKDEGYIDDFAVKAEGAKSELNIALKYYAGRPVIERLERVSKPGLRVYRGRNDIPQVMNGLGVAIVSTPKGVMTDRKARATGVGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: CH10_SHEWM
Sequence: MNIRPLHDRVIVKRSEVESKSAGGIVLTGSAAEQSTRGEVLAVGNGRILENGSVQPLDVKVGDMVIFNEGYGVKKEKIDGEEVLILSESDLMAVVS
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLME_TREDE
Sequence: MRWKNKKIPEGEFMEMREEILQTWPTGKDVDLKESIDYLKKIPPEKNFAIKLEQADKEGITTAQPRAGVPLLDEHINLLQFLQDEGGADFLPSTIDAYTRQNRYEEGEAGIEASKKAGRSLMNGFPAVNWGVGPCRQVLEAVNLPLQARHGTPDARLLSEIIHAGGYTSNEGGGISYNVPYAKAVSIEHSIMCWQYADRLVGFYEENGVHLNREPFGPLTGTLVPPSVAIAVGVIEALLAAEQGVKSITVGYGMCGNMTQDVAAVISLREITKDYMKKFGYKDMCITTVFHQWMGGFPADESRAYGLISLGSTTAALSGATKVIVKTPHEAFGIPTKEANAGGIKATKMVLNLLKGQRYPDSRVLAQEIELIKAETKCIMDKVYEIGGGDLVEGTIKAFEAGVIDIPFAPSQYNAGKVMPARDNDGCIRYLMPGNLPFTKDILDFNRGKLEERAKADKREVDFQMSVDDVYAVSSGVLVGRPAKR
What is the function of this protein?
Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
What are the official names of this protein?
Glutamate mutase epsilon subunit, Glutamate mutase E chain, Glutamate mutase large subunit, Methylaspartate mutase.
What is the protein family that this protein belongs to?
Belongs to the methylaspartate mutase GlmE subunit family.
Protein: CDC6_METHJ
Sequence: MTQDMNDSPGLFDKYLSENRIFRDREVLRHSYRPHILPHRKPQIDQIAAILAPALQTETPSNILIYGKTGTGKTASVRYVGSELESVSARRGTVCRVIHLNCEVIDTQYRVLAQISKLIMGEDETPSDKIKTHIPMTGWPTDQVYSELKNQIELNSGVFIIILDEIDKLVKKSGDDTLYNLTRINTDLNRSKVSIIGISNDLGFKTFLDPRVLSSLSEEELVFPPYNAPQLCDILQQRAVIGFAEDALEDEVIPLCAALAAQEHGDARRALDLLRISGELADRENGSKVTVEHVKKAQAKIETDSMVECIRTLPTQSKIVLYCMLLLHRAGQRIFISGDVTRIYKELTPFLEIDVLTARRISDLISELNMLGVINTRLVNRGRHGRTKEMWFDTNTDKIWEVIMEESDGRLAQVDEQIVVQILR
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: ATP10_ASHGO
Sequence: MVIWRRYLSGTAQPLVFKKMNKALAQAAPREHVVRRLEQPVGMPQPPTAATRYVEGNSMLDMFSEEKTSRRAAELAAEFSKSGLYDAATFRKTNGRVFLPPASYWRAEHARYFPHLGGRTLTGARGSVEDVLAGKVSVVKVFSCETGEGLASSYFRHEGHDYLREDDVAPAQIVEISLTESWIKDWLVRLMAGRLRSLVPAARHERYFICRRAQLPFTVRESLELGNLYTGYVLVVDPQLKIRWMACGGAEKRDAELLWKCVRGVQRECAAV
What is the function of this protein?
Involved in assembly of the mitochondrial F1-F0 complex.
What are the official names of this protein?
Mitochondrial ATPase complex subunit ATP10.
What is the protein family that this protein belongs to?
Belongs to the ATP10 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane.