PharMolix/UniProtQA huggingface dataset:
Protein: RS12_ANADE
Sequence: MPTISQLVRRGRERLQVKKKAPALKESPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGFEVTSYIPGVGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGTLDAVGVQGRKQGRSKYGAKRAS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: ULAE_SALDC
Sequence: MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDARLARLDWSREQRLALVSAVAETGVRVPSMCLSAHRRFPLGSEDDAVRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQQANDETRCRFRDGLKESVDMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAENPAAEVAKARDWVKARMASAGLVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.
Protein: COFG_METMA
Sequence: MTYSKNVFIPVTNICRNQCGYCGFRREPGQPGARLMKPEEVISVLENGVRAGCTEALFTFGERAEEVPGYGEMLEEIGYSSTLEYLVFLCETAIDIGILPHTNAGIMTRSELEALKPLNASMGLMLESTAVLAAHKDCPGKIPERRLETIREAGKLKIPYTTGLLIGIGESRDDRIESLEAIAALHREYGHIQEVIIQNFAPKPGTEMENFPEPAVEEMMDSVELAARILPGDVAVQVAPNLIDPKSLIAKGVTDLGGISPLTIDWINPEAEWPDVKNLQKKLGDIPLKERLPVYPPYVKKGWYSERIGSLIKRLSDNSGYRKQPGTENAEDSEK
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
What are the official names of this protein?
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, FO synthase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofG family.
Protein: HEM1_PROMH
Sequence: MTLLALGINHKTAPVALREKVSFSPDTMGDALNNLLQQPAVRGGVVLSTCNRTELYLSLEDKENSHEQLISWLCQYHQIEPHELKNSVYWHQDNQAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQNYHSLSSELERLFQKSFSVAKRVRTETQIGANAVSVAFAACTLARQIFESLSSLTILLVGAGETIELVARHLREHQVKKIIIANRTKERAQRLANEVDAEVITLSDIDESLSQADIVISSTASPLPIIGKGMVERALKKRRNQPMLLVDIAVPRDIEQDIEKLSNVYLYSVDDLEAIIQHNREQRQAAAIEAEHIVQQESGQFMDWLRAQGAVGAIREYRDSAEMLRAEMAEKAIALIQNGADAEKVIQQLSHQLMNRLIHTPTKSLQQAASDGDIERLNLLRESLGITHN
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: KR2_EBVG
Sequence: MDVNMAAELSPTNSSSSGELSVSPEPPRETQAFLGKVTVIDYFTFQHKHLKVTNIDDMTETLYVKLPENMTRCDHLPITCEYLLGRGSYGAVYAHADNATVKLYDSVTELYHELMVCDMIQIGKATAEDGQDKALVDYLSACTSCHALFMPQFRCSLQDYGHWHDGSIEPLVRGFQGLKDAVYFLNRHCGLFHSDISPSNILVDFTDTMWGMGRLVLTDYGTASLHDRNKMLDVRLKSSKGRQLYRLYCQREPFSIAKDTYKPLCLLSKCYILRGAGHIPDPSACGPVGAQTALRLDLQSLGYSLLYGIMHLADSTHKIPYPNPDMGFDRSDPLYFLQFAAPKVVLLEVLSQMWNLNLDMGLTSCGESPCVDVTAEHMSQFLQWCRSLKKRFKESYFFNCRPRFEHPHLPGLVAELLADDFFGPDGRRG
What is the function of this protein?
Plays many key roles by phosphorylating several proteins including the viral DNA processivity factor BMRF1, EBNA1 or EBNA2.  Modifies the host nuclear envelope structure and induces the redistribution of nuclear envelope-associated proteins by phosphorylating host nucleoporins.  Subsequently, promotes the nuclear transport of EBV lytic proteins.  Required for efficient lytic DNA replication and release of nucleocapsids from the nucleus.  Contributes to the compaction of host cell chromatin in cells undergoing lytic replication, presumably by phosphorylating the host condensin complex and host TOP2A.  Induces disassembly of the nuclear lamina by phosphorylating with host LMNA.  Phosphorylates substrates involved in capsid assembly and DNA packaging.  Facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function.  Phosphorylates the viral immediate-early protein BZLF1 and inhibits its sumoylation by interacting with host SUMO1 and SUMO2.  Phosphorylates also host SAMHD1 and thereby counteracts its antiviral effect by reducing its dNTP hydrolase activity.
What are the official names of this protein?
Serine/threonine-protein kinase BGLF4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Virion tegument. Host nucleus. Note=the protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs.
Protein: HISZ_PROM1
Sequence: MTLQPASGARDLNPQQVRKNHLIASKLSSLYQLWGYERISPPHIERLDTLTAAGGISNNEILKIVSDEPLGLRPEITASIVRAASTRFNEYERPLRFWSAGTSFKCNQSIDGGIDIEESFQSGVELIGTKAINAEIELLSLLIESLEVIEIDQKYKMTLLIGNTYLLELILSSFDSTKIDQIKKILCDLDYIALTTLDVKEEQRMFIKTIMNMRGKPEEVLTNLQNIYGSNSYIDKLKELFTIIEPLAKEKGIEVQLDPTLGTKYKLYSGLTFSLVSSSTSAPVTIAKGGRYDDLVKKFSSSAQNCYGIGFSISVDKVRELVSTSKEKLVNNVKVLIAYKQSANLYKALKQQKELHRKGIISVISHEPLKTNDETNQLLKSNRCNKIEWID
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XYLG_BURCM
Sequence: MTEPLLTMRGIVKAFDGVKALDGIDLTVRPGECVGLCGENGAGKSTLMKVLSGVYPHGTWDGEIRWEGAPLVASGVRDTERAGIVIIHQELMLVPELSVAENIFLGNEITLPGGRMHYAEMVRRSEALLRDLRIDAINVAQPVMNYGGGHQQLIEIAKALNKRAKLLILDEPSSSLSAAETRILLDIVRDLKRRGVACVYISHKLDEVDAVCDTVTVIRDGRHVATEPMSTLTTDRIIAMMVGREIRNLYPREPHEIGDVVLEARNVTCHDVANPRRKRVDDVSFAVRRGEILGVAGLVGAGRTELMQAIFGAYPGASTASIRMNGRPLAIRAPADAIRAGIAMVPEDRKRHGIVPQLGVGHNITLSVLRRFATRGRIDAAAELDAIRTEMQRLSVRAAHPFLPIASLSGGNQQKAVLARMLLADPQVLILDEPTRGVDVGAKAEIYRLIFALAKRGVALIVVSSELPEVLGLADRVLVIGEGELRGDFVNDGLTQEQILGAALTPARRPAEPIAASNP
What is the function of this protein?
Part of the ABC transporter complex XylFGH involved in xylose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Xylose import ATP-binding protein XylG.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CA11C_CONQU
Sequence: SDGRNTAANDKASNLMALRDDCCPNPPCKASNPDLCDWRS
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity).  Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity).
What are the official names of this protein?
Alpha-conotoxin-like Qc1.1c.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SECA_BORPE
Sequence: MVSLLKKLIGSRNDRLLKEYRKQVAQINSLEPKISALSDEELSAKTQEFRDRHQQGTSLDDLLPEAFAVVREAGKRVFGMRHFDVQMLGGIALHNGKIAEMRTGEGKTLMATLPVYLNAIAGKGVHVVTVNDYLARRDAEWMGRLYRFLGMSTGVVVPQQPNDEKIAAYAADITYGTNNEFGFDYLRDNMEYRVEDRRQRRLFYAIVDEVDSILIDEARTPLIISGQAEDHTELYVRMNAVPPLLKRMASEPKPHEPEPEGDYWVDEKSQQVYMSEAGHESAEKILTRVGLLPEGESLYDPRHIALMHHMMVALRAHTLFFRDQQYVVQDDEVVIVDEFTGRLMVGRRWSDGLHQAVEAKEGVKIQHENQTLASITFQNYFRMYDKLSGMTGTADTEAYEFQEIYTLETVIIPTNKPMVRKDQNDQVFKTTQEKYQAILNDIRDCHERGQPVLVGTTSIENSELLAGLLRQAKLPHEVLNAKQHAREAEIVAEAGKPGHITIATNMAGRGTDIVLGGSVDKQVDLIHANEALSEAEKEARIETLRAEWKPLNERVKQAGGLRIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDPLMRIFAGDRVRAIMERLKLPEGEPIEAGMVTRSIETAQRKVEGRNFDIRKQLLEYDDVANDQRKVLYSQRNEVLEAASIGATVEGLRDAAVAEMFRGFIPEESVEEQWDVAGLEKALAGDWHIQLPLTDMLEQEPNLTDEELLERVVAAARQIYTAKVEQVGAESWAQFERSIMLQSIDTHWREHLSALDYLRQGIHLRGYAQKNPKQEYKREAFELFSGMLDRIRDDVVRVLMTVRVQSAEQVEQAEADAAQPHVQNVQYHHSDYDEALADDGQPQGAQPVRNVLPKVGRNEPCPCGSGKKYKHCHGQLA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: TSGA_YERPP
Sequence: MNNSNRIRLTWISYLSYALTGALVIVTGIVMGNIAEYFNLPIASMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLVFGFILMLIAIAGLMVGHNLMIFSISMFIFGVVSGITMSIGTFLVTHMYEGRQRGSRLLFTDSFFSMAGMIFPIAAAMLLARHIEWYWVYACIGLLYVGIFVLTLCSEFPVLGHKATDQSKPVVKEKWGVGVLFLAIAALCYILGQLGFIQWVPEYATKTFNMNISQAGQLVSNFWISYMIGMWIFSFILRFFDLQRIVTVLAAMATLAMYLFVSTDNPAYLSYYILALGFVSSAIYTTLITLGSLQTKVSSPKLVNFILTCGTVGTMLTFVVTGPIVANNGVHAALETANGLYLAVFILCLALGFFTKHRSHGHVTH
What are the official names of this protein?
Protein TsgA homolog.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TsgA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RMT2_YARLI
Sequence: MSFTEEETKLGKSLFEACSFTERPIAKDSHLETVRQVMRKNIPATITTSDLGLFTDEEEATKKKEIIQGDITIDGTTPLHVICSSFPSDATAEELEVALEMMRELFQWGAGWMLLDEQGQTPGCVAWDRSKAEARDSVLASVYNEIVSAGTRSEVFLRRINKSENVEFLSDDDDEEMDVDDDEEDESRDGEETGDIQQAIADAIKQAKEAGLEVVVDGETVEEVPELVGDKEDEKNNESAAQNEVDLAGSQMDYLKDKLTYTDDNKTLITTQNDGVMMDWEDEIMQKSADLLVSRADKESDGPVVLNVGFGLGIIDTYLQSKKPSKHYICEAHPDVLEKMEKDGWMDKPGVTVLVGRWQDTLPGLLSQGVYFDGMYYDTFSENYSDLVDFFDHVVGLLAPTGVFSFFNGLGADRQVCYDVYKNVVEVDLQEYGLNVEYQVIKVNKDVTGADGHVWDGIKRRYWVVEDFYLPVCTF
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins.  Monomethylates ribosomal protein L12.
What are the official names of this protein?
Protein arginine N-methyltransferase 2, Protein-arginine N5-methyltransferase, Type IV protein arginine N-methyltransferase, Type IV PRMT.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: STS1_CANAW
Sequence: MMSTNFQWPGTNKNDNTEVSVETPSSTDPHVPRYPFTAMSHATASTTMKKRKRDDFDGDKSTTITMNTTTTRKYIQSSLGSSKFKKAKTPKISGQPLPLPRLIESLDKSNLQKLVQDLITVHPELQSTLIKISPRPSIQDSIQLLQDKFDMIISHLPYKCDVESDYSYLRIKPHLQEFLSSVSDFILNYLPPLETNMTHSLQFLHETTKLVYNLPNFTNQEFQYTKSSALEQIANCWLIVLSQDEEKEGNTDVVKVIQELELLEKLHEHNEISFNKFEKVVDYCKDKLEQHELIMNNNEAGSGVTSSISDLITVDYSKYSIANTTSI
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NECP1_MOUSE
Sequence: MAAELEYESVLCVKPDVSVYRIPPRASNRGYRASDWKLDQPDWTGRLRITSKGKIAYIKLEDKVSGELFAQAPVEQYPGIAVETVTDSSRYFVIRIQDGTGRSAFIGIGFTDRGDAFDFNVSLQDHFKWVKQETEISKESQEMDNRPKLDLGFKEGQTIKLSIGNITAKKGGASKPRASGTGGLSLLPPPPGGKVTIPPPSSSVAISNHVTPPPIPKSNHGGNDSDILLDLDSPAPVSTSAPAPVSTSNDLWGDFSTASSSVPNQAPQPSNWVQF
What is the function of this protein?
Involved in endocytosis.
What are the official names of this protein?
Adaptin ear-binding coat-associated protein 1, NECAP endocytosis-associated protein 1, NECAP-1.
What is the protein family that this protein belongs to?
Belongs to the NECAP family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell membrane. Note=Colocalizes with AP-2 at the plasma membrane.
Protein: COAE_AERHY
Sequence: MYVVAITGGIGSGKTTIANQFAELGIDVVDADVIAREVVEPGAPALAAIAAHFGPDVIAADGQLDRRSLRERVFSDPDAKVWLNALLHPLIRQEMFGRCAAAHSPYCLLVVPLLVENKLTGLANRVLVIDVDEATQIERTCRRDGVSREQVQAILAAQASRAERLAAADDVLDNKNGAPETIKPRILALHETYMAFASQQASQV
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_BRADU
Sequence: MKAEIHPDYHTIKVVMTDGTEYLTRSTWGKEGDTLNLDIDPKSHPAWTGGNAQIMDRGGRVSRFQKKFSGFLKKD
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: MNMG_KARMG
Sequence: MFVKQYDVIVVGGGHSGSEAALAASNLGSNTLLITTNLYNIGQMSCNPAMGGIAKGQMIKEIDALGGYSGIITDKSMIQFRMLNKSKGPAMWSPRAQCDRLKFSKEWRLTLEKKKNLSFFQSTVVDLIIKNYKVIGVKTILGIYIKSKSVILTNGTFLNGIIHIGDKKNSGGRISENSVKGLTEKLKKIGFFSGRMKTGTSPRLDGRSLDFSKMIEQLGDFPIEPFSYLSNLNILKQKKCYITHTNLETHNLLSKEFNRSPIFNGKIKCVGPRYCPSIEEKVYRFSNKENHQIFVEPEGVNTIEVYINGFSTSMPEEVQYKALLTIPGFEHAKMVRPGYAIEYDYFPPTQLKNNLETKLIENLFFAGQINGTTGYEEAAAQGLIAGINANLKINEKDPFILKRNEAYIGVLIDDLIYKGTEEPYRMFTSRAEYRILLRQDNADERLTHMGINLGLVSYDRIKKLKNKNKNKKQCFLFFKINKANNLILKENIKICDLLSRPEISIYDIIKLSLIKNFIKKNNIDKKILEQISLYIKYKGYLLKEEENVKKMYRLETIRIPNDFDYNQVKSISIEAREKLLNYKPNSIGEASRISGVSPSDIRILILFLIKK
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
Protein: ATP6_PROMT
Sequence: MGFLPFVFPFAELEVGQQLYWQIGNFRIHGQVFMTSWLLIGALLALVVIGTKKMERDPRGVQNLLEFLWDYIRDLARTQIGEKVYRDWMPFIGTLFLFIFVSNWGGALVPWKLIKLPSGELGAPTADINTTVALALLVSLSYFYAGLSNKGLRYFEYYVHPTPIMLPFKIVEDFTKPLSLSFRLFGNILADELVVAVLVFLVPLVLPVPVMFLGLFTSAIQALIFATLAAYYIGEAVEEHH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PBPA_RICBR
Sequence: MYKSLFFCLKILALLFLIGCGIVAYIIYYYSRDLPDYRQLARYYPPSVTRIYSRDGKLMEEYAFERRVFIPINSIPTSLKESFIAAEDKNFYNHQGVDLFGIVRAAFLNISNFLHHRRMEGASTITQQVVKNFLLTNEVSFQRKIKEAILSYMISRVFTKDQILELYLNQTFFGRGAYGVATAAQNYFNKSVEELTIAESAFIAALPKAPSELNPEKNYARVKARRDYVIMRMLEDGYITSDAAKEAVDSPITLRKRDQDETVTADYYAEQVRDEVIKMLGSKDEFYTSGLTIITSLDAKMQKFAEESLRKGLRDFDRKRGFRKAIATISLDNWQEELKKLPTTPSLLEYKIAVVLEVTDTQAEIGFASGAKSKIPISEMKWAKSELKSAKKLLTKGDVIVVEPVKDYYALRQIPEVNGAIMVMNPNTGQVLTSVGGYDFFASKFDRVTQALRQPGSLSKTFVYLAALENGVKPNQIFNDGPIEISQGPGMPSWRPKNYEGKFLGPITMRTGLEKSRNLVTVRVATAVGLTKIVDIIKRFGINDNPQKVYSMVLGSIETTLERITNAYGIIANGGKRIKPHFVELIKDRNGKVIYRRDDRECTTCNVSDNDLDNAILEIPAENIYMVTDAASDYQITSLLTGVVDRGTAYSAKKLGKVIGGKTGTSNDSKDTWFIGFTPKIVVGSYVGYDTPRTLGRRATGSSVVLPIFIDFMSNAYKDEPPLPFKVPDSVKLQAVDRATGQITPSGSVMEAFKINNILIIEDDSEIIDNNHNNDVFDYVPTEKDQSQEIY
What is the function of this protein?
Cell wall formation.  Synthesis of cross-linked peptidoglycan from the lipid intermediates.  The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
What are the official names of this protein?
Penicillin-binding protein 1A, PBP-1a, PBP1a.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transpeptidase family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: KDSR_DICDI
Sequence: MIIYILFSLLAAVIVHLVYKKQTGFKLKGKHIVVVGGSSGIGKELVYELLKENIASISVISRSLDKLRSVVDDCPSEVCTKSTPLNVGSLKSKIEIYSCDITNKIKVKETIAQIVSKNQGGKIDCLINCAGFAIPGYFIEQDEEIFEKTMQLDYFGSLYATKEVVPLMIENGGQGGHIVFVSSTCGLVGVPGYSTYCPSKFALRGLAETLRSELKPYKITFSVVYPPDTDTPGYQQENLTKPEETVAISGGGKAVSPLEVAKSIVSGIKNGDYHIAYDVPTKLCAVLSPGLTPFYFSFFDILLAPICRLVGIIAMNQNDAEVLKSWKKRNQLKK
What is the function of this protein?
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
What are the official names of this protein?
3-ketodihydrosphingosine reductase, KDS reductase, 3-dehydrosphinganine reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: UDP_SALTI
Sequence: MSKSDVFHLGLTKNDLQGAQLAIVPGDPERVEKIAALMDKPVKLASHREFTSWRAELDGKAVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGASLHFAPMEFPAVADFACTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRRFKGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESHAVKIVVEAARRLL
What is the function of this protein?
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.
What are the official names of this protein?
Uridine phosphorylase, UPase, UrdPase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRB_CHLPD
Sequence: MHGITDGTYRLVSEYDPKGDQPKAIMALTDGVLRGDRWQTLLGVTGSGKTFTVSNVIAQVDKPVLVMSHNKTLAAQLYGELRQFFPDNAVEYFVSYYDFYQPEAYLPALDKYIAKDLRINDEIERLRLKTTSSLLSGRRDVIVVSSVSCIYGLGSPDDWKAQIVELRSGMEKDRDLFLQELVSLHYIRDDVDPGPGKFRVRGDIIDLVPAHEELALRVEFFGSEIESLQTFNIQSGELLGKDTYAFIYPARQFIAEAETLKQAMVAIENELAGRLNELRRDDRLVEARRLEERTRYDLEMMKELGYCSGIENYSRHLAGRSEGERPYCLLDYFPEDFLVIVDESHVTLPQIRGMYGGDRSRKAILVEHGFRLPSALDNRPLRFEEFTEIVPQVICVSATPGDLELERCGGVVVEQLVRPTGLLDPPVEVRPVKGQIDDLLAEIRRHTAKGHKALVMTLTKRMSEDLDDYFKKVGIRSRYLHSEIKSLERIQILRELRAGDVEVLVGVNLLREGLDLPEVSLVAILDADKEGFLRNTRSLMQIAGRAARNVDGFVVFYADVLTRSIMEVLDETARRRTVQQLYNETHGITPRSIRKSLDQVLNTTSVADAEERYRRKRFGLGAKSGVQSAALLHSFTPEESYAMVAELRLEMNEAAIQMEYEKAAYLRDEIARLMHGLEAQSDSKE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_PELPB
Sequence: MKLIVGLGNPESRYIGTRHNIGFSAVEKIAASFGANFSKGKGKSLEAKITHRGEQVIIIKPMTYMNLSGHAVVAAMNFYKIVRNDILIICDDLNLPSGTIRLRAKGSAGGQNGLKHIIESLGSEEFARLRIGIRVDETSLTSFSSFVLGKFSENEKVVMEKILPITSDAALDFTINGIEHAMNNYNKPVT
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYN_BACCN
Sequence: MENTLVKSLYRETDKYVDQKVQVSGWIRNLRDSKVFGFIELNDGSFFKSVQIVFDTELDNFKEITKLPLSSSIRVEGKFIATPTAKQPFEIKAEKIEIEGLSDSDYPLQKKRHTFEYLRTIAHLRPRTNAFSATFRVRSIAAYAIHKFFQERGFVHVHTPIITGSDTEGAGEMFRVTTHDMNNLPKGEDGQVDDSKDFFGRETNLTVSGQLPAEAYALAFRDVYTFGPTFRAENSNTTRHAAEFWMVEPEIAFAELEDVMDLTEDMLKYAMKYVLEHAPEEMEFFNKFVDKTVLERMNNVINSDFGRITYTEAIKVLQESGADFKYPVEWGIDLQTEHERYLSEQVFKRPVFVTDYPKDIKAFYMRMNDDGKTVAATDLLVPGIGELIGGSQREERMDVLVDRIKELGMKEEDYWWYLELRKYGGTKHAGFGLGFERFLMYITGMGNIRDVIPFPRTPGSAEF
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HECD2_HUMAN
Sequence: MSEAVRVPSPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGLDRGAKGQISTFSSFISAVSPKKEAAENRSSPAHLVFPNIKNVREPPPICLDVRQKQRTSMDASSSEMKAPVLPEPILPIQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAFKKDATASFNTIEDSGINAKFVNAVYDTLLNTPQDVQKTVLKGIINSLLREWKGPRTKDDLRAYFILLQNPQFNNTSTYVIYAHLLRQIATLVEADHHFLVHWFKKLSQKRFKQLVERLLQFISLRLFPAKPEEFPPITKCSWWIPSAAKVLALLNTANNLVHPPLIPYTDFYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYPFVISVAAKKIIIQRDSEQQMINIARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDELTRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSELLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQYDGYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE
What is the function of this protein?
(Microbial infection) Catalyzes ubiquitination of Botulinum neurotoxin A light chain (LC) of C. botulinum neurotoxin type A (BoNT/A).
What are the official names of this protein?
Probable E3 ubiquitin-protein ligase HECTD2, HECT domain-containing protein 2, HECT-type E3 ubiquitin transferase HECTD2.
Protein: MLTG_ECOLI
Sequence: MKKVLLIILLLLVVLGIAAGVGVWKVRHLADSKLLIKEETIFTLKPGTGRLALGEQLYADKIINRPRVFQWLLRIEPDLSHFKAGTYRFTPQMTVREMLKLLESGKEAQFPLRLVEGMRLSDYLKQLREAPYIKHTLSDDKYATVAQALELENPEWIEGWFWPDTWMYTANTTDVALLKRAHKKMVKAVDSAWEGRADGLPYKDKNQLVTMASIIEKETAVASERDKVASVFINRLRIGMRLQTDPTVIYGMGERYNGKLSRADLETPTAYNTYTITGLPPGAIATPGADSLKAAAHPAKTPYLYFVADGKGGHTFNTNLASHNKSVQDYLKVLKEKNAQ
What is the function of this protein?
Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.
What are the official names of this protein?
Endolytic murein transglycosylase, Peptidoglycan polymerization terminase.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase MltG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.