PharMolix/UniProtQA huggingface dataset:
Protein: RSXE_ECOK1
Sequence: MSEIKDVIVQGLWKNNSALVQLLGLCPLLAVTSTATNALGLGLATTLVLTLTNLTISTLRHWTPAEIRIPIYVMIIASVVSAVQMLINAYAFGLYQSLGIFIPLIVTNCIVVGRAEAFAAKKGPALSALDGFSIGMGATCAMFVLGSLREIIGNGTLFDGADALLGSWAKVLRVEIFRTDSPFLLAMLPPGAFIGLGLMLAGKYLIDEKMKKRRTEAVAERALPNGETGNV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit E, Rsx electron transport complex subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MURA_XANOM
Sequence: MAKIVVTGGQALQGEVNISGAKNAVLPILCATLLADAPVQISNVPHLHDVITMVKLLSELGAEVTIDEGTLAKGRSILVDPRSVTHQIAPYELVKTMRASILVLGPLLARYGTAEVSLPGGCAIGSRPVDQHIKGLQALGAEISVENGYIKATSHGRLKGGRYVFDMVSVTGTENVLMAAVLAEGTTVLENAAMEPEVTDLADCMIALGAQIEGAGTPRIVVQGVQRLGGGHHAVLPDRIETGTFLVAAAMTGGSVTVRRARPETLDAMLDKLTEAGATITTTADSITLDMQGKRPRAVSLTTAPYPAFPTDMQAQFMALNCVADGVGVINETIFENRFMHVNELLRLGADIQVEGHTAIVRGAARLSGAPVMATDLRASASLILAGLVADGDTTIDRIYHLDRGYENIEEKLGALGATIQRTA
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_WOLSU
Sequence: MRILVFLWLGLSSLFAVDATLEVVKKFANMPSIIVEDSSTREVERGLTLRVYKMLVGDLKVSSHFNVQEGGASSFDMVMDYGAYRQKKVDLVAKVKAGREGSGILAELRLYDVNSGDSVFAKSYTVAREDRYPFVAHKMAIDINNYIKAPSIDWMNRFVVLSKYTAPSESQIVVADYTLTFQNVIIKDGRLNIFPKWANEQQDAIYYTKYLTKPTLFRYNLYTGESRKITESEGMLVASDVSADGKKLLLTMAPHTQSDIFLFDTQTGTRKQLTRYPGIDVSAHFIEDERRIMFISDRLGYPNVFATGLDGSETVEQMVFHGRNNNAASAFGQYIVYSSRESSNEFDTNTFNLYLVSTKSDYIRRLTANGVNQMPRFSQDGETVMYLKHNGAQSALGVIRLNYNKSYLFPLPSGKIQSMDW
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: VPC41_MYCTU
Sequence: MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDDRIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase (By similarity).  Upon expression in M. smegmatis inhibits colony formation.  Its toxic effect is neutralized by coexpression with cognate antitoxin VapB41.
What are the official names of this protein?
Ribonuclease VapC41, RNase VapC41, Toxin VapC41.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
What are the subcellular locations of this protein?
Secreted. Note=Following 6 weeks of nutrient starvation.
Protein: AAK1_RAT
Sequence: MKKFFDSRREQGSSGLGSGSSGGGGSSSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIYMLEPDPDKRPDIYQVSYFSFKLLKKECPVPNVQNSPIPTKLPEPVKASEAAVKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPLPQATGPSNQPSLLASVSQPKAQATPSQPLQSSQPKQPQAPPTPQQTPAPQTQGLPTQAQATPQHQQQLLLKQQQQQQQQQQQQQPQQPTAPPQPSGTFYQQQQPQQQQAQTQQQFQAVHPAAQQSVTAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQLMAQQAALQQKTAVVVPQPQAQPATAPQAAAAQEPQIQAPARQQPKVQTTPPPTIQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLHAAAAEASLSKSKSATTTPSGSPRTSQQNVSNASEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKLPEKLGGSAESLIPGFQATQGDAFATSSFSAGTAEKRKGGQAVDSGIPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADAAVESLIPGLEPPVAQRLPSHTESVTSNRTDSLTGEDSLLDCSLLSNPTADLLDEFAPIALSASTHKAAEDSNLISGFGVAEGSEKVAEDEFDPIPVLITKNTQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
What is the function of this protein?
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:11877461).  Preferentially, may phosphorylate substrates on threonine residues (By similarity).  Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (By similarity).  Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (By similarity).  Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (By similarity).
What are the official names of this protein?
AP2-associated protein kinase 1, Adaptor-associated kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Presynapse. Note=Active when found in clathrin- coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells.
Protein: COAE_GEOMG
Sequence: MLVIGLTGGIASGKSTVARILERLGATIIDADLLAREAVLPGTPAHRAIVAAFGTEILLPDATIDRKALGRIVFANPDARRRLEAITHPAIARLSQARLAEARRSDAPAVFYVAPLLIEAGAADRVDDIWVVYADRETQLARLTERDGIGRGEAEQRLAAQMPMDEKASYGSAVIDNRGTSEETERQVVALWKERIEKNPR
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_DESHY
Sequence: MEQNHGLLIVLSGPSGAGKGTLCQELLRQLPQVKYSVSATTRQPRPGEMDGLHYYFRSREEFQTMIEQDQLLEWAEFCGNYYGTPQFAVEQAIQAGNDVILEIEIQGALQVKQRFPQGVFIFVVPPSMDELSQRIHKRGTESEEVIQKRLQTAARELEYVSEYDYVVVNDEIPLAVDKLKSILLAEKCRVKRKPYVFQGV
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MED23_DANRE
Sequence: METQLQSIFEDVVKTEVIEEAFAGMFMDSPEDEKTKLTSCLGAFRQFWSTLPQESHEQCVQWIVRFIHGQHSPKRIAFLYDCLAMAVETSLLPPRMVCQALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKAVLDKIQTIPNFVSSAVVQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLCPEGALSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPYDKDLFDPQTGLLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALGDFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLPMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCMASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSLALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPIQLQSQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKCGMNAREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIVSVISSAVLSSGSDWLGYPFQLLDFTACHQSYSEMHCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSNHLAYMDPICDFLYHIKYMFTGDSVKDQVERIICSLRPAMRLRLRFITHISKMEPAAVPVSNSSSVQQTSSASSPTAQSTAGAAIPLSVTQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 23, Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subunit 3, Mediator complex subunit 23.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 23 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LET23_CAEEL
Sequence: MRYPPSIGSILLIIPIFLTFFGNSNAQLWKRCVSPQDCLCSGTTNGISRYGTGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVFHDNALYIHKNDKVHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCNDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDGHLTNETLKNLEGCEQIDGHLIIEHAFTYEQLKVLETVKIVSEYITIVQQNFYDLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQTSMKCERCSPECETCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQCVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNGDYYNQPNTPSSSSGYYNEPHLKTKKPETSEEAEAVQYENEEVSQKETCL
What is the function of this protein?
Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway.  Each pathway regulates distinct functions.  By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis (PubMed:2071015, PubMed:8313880, PubMed:9491893, PubMed:20230814, PubMed:32053105).  Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade downstream of ligand lin-3, plays a role in ovulation by promoting ovulatory gonadal sheath cell contractions (PubMed:9491893, PubMed:15194811).  Probably by regulating neuronal transmission in ALA neurons, mediates, independently of let-60/Ras, the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, downstream of lin-3 and upstream of plc-3 (PubMed:17891142).
What are the official names of this protein?
Receptor tyrosine-protein kinase let-23, Lethal protein 23.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note=Basolateral and apical membrane of cell junctions in epithelial vulval precursor cells.
Protein: RL5_CHLPB
Sequence: MAEKKEKVKPTEQQKARLENTYKDKVVPALMERFKYKNIMMVPRLTKISVNIGVGEAAAEPKLLETAIQELSQITGQKPQIRKARKAISNFKLREGQAIGCRVTMRKKYMYEFLERFVTLAVPRIRDFRGLSTTSFDGRGNYSVGVREQIIFPEIDIDKVPRIQGMDISFVTTAKTDEEAFALLSELGMPFRKKNN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: Y4RL_SINFN
Sequence: MLEREDPVMLFAGIRAAQEELGKRVDCRGLNAGTEEPLAIDLQRFTVSLKTAWQAGEKRPTHRRPYRRTKPYPKRPSMLEPFEPQIRAWLEADPALSAAAVLQRLVSADPSRFTKKALRTVQMAVKAWRMEIAGQIILDGDWMKRAPVSQCPQLQ
What are the official names of this protein?
Putative uncharacterized protein y4rL.
Protein: MORN_HYDVU
Sequence: QPPGGSKVILF
What is the function of this protein?
HA acts as an autocrine growth factor for neural cells in the G2/mitosis transition.
What are the official names of this protein?
Morphogenetic neuropeptide, Head activator, HA.
Protein: ATPA1_BURMS
Sequence: MQLNPSEISELIKSRIQGLEASADVRNQGTVISVTDGIVRIHGLSDVMQGEMLEFPGNTFGLALNLERDSVGAVILGEYEHISEGDIVKTTGRILEVPVGPELVGRVLDALGNPIDGKGPVNAKLTDAIEKIAPGVIWRKSVSQPVQTGLKSIDSMVPIGRGQRELIIGDRQCGKTAVAIDTIINQKGKDLICIYVAIGQKASSIMNVVRKLEETGALEYTIVVAASASESAAMQYLAPYAGCTMGEYFRDRGQDALIIYDDLTKQAWAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVSEEYVEKFTNGEVKGKSGSLTALPVIETQAGDVTAFVPTNVISITDGQIFLETDLFNAGIRPAINAGVSVSRVGGAAQTKVVKKLSGGIRTDLAQYRELAAFAQFASDLDEATRKQLERGRRVTELLKQPQYQPLQVWELAVSLFSANNGYLDDLDVKDVLPFEKGLREYLKTSHADLIKRIEDTKDLSKDDESALHAALKDFKKSGAY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL11_CHLTB
Sequence: MSNKKIIKIIKLQIPGGKANPAPPIGPALGAAGVNIMGFCKEFNAATQDRPGDLLPVVITVYSDKTFSFVMKQSPVSSLIKKALGLESGSKIPNRNKVGKLTRAQITAIAEQKMKDMDVVLLESAERMVEGTARSMGVDVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: ILVC_HYDCU
Sequence: MQVYYDKDCDLSIIQGMKVAIIGFGSQGHAHAANLQDSGVDVTVGLRPGSSSIKKAEGYGLKTADVATAVAGADVVMILTPDEFQSVLYKEEIEPNIKQGAVLAFAHGFAIIYNQIEPRKDLDVIMIAPKAPGHTVRSEFVRGGGIPDLIAIQQDASGKAKEIALSYASGVGGGRTGIIETTFRDECETDLFGEQAVLCGGAVELVKAGFDTLVEAGYEPEMAYFECLHELKLIVDLMFEGGIADMNYSISNNAEYGEYVTGPRVINDESRAAMREALKNIQTGEYAKQFILEGQSNYPSMTAARRLNEEHGIEVVGRKLRAMMPWIASNKIVDQEKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RSMG_ECOLI
Sequence: MLNKLSLLLKDAGISLTDHQKNQLIAYVNMLHKWNKAYNLTSVRDPNEMLVRHILDSIVVAPYLQGERFIDVGTGPGLPGIPLSIVRPEAHFTLLDSLGKRVRFLRQVQHELKLENIEPVQSRVEEFPSEPPFDGVISRAFASLNDMVSWCHHLPGEQGRFYALKGQMPEDEIALLPEEYQVESVVKLQVPALDGERHLVVIKANKI
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.  Requires the intact 30S subunit for methylation.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase, Glucose-inhibited division protein B.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOLB_FRAT1
Sequence: MRNGMRKIIAGVFIFVFLISNLYADLVAEVTTGVIQKPLVTVVSDNVVDQFPQQVNSVIVADLNHNAKLQANDTIKYEIKQKQNIPWKSLKSDYVVLTKYTNNSYNNYTVEVQILKRNDTSYLQAITYKNINVSLMRTLAHKISNYVYQKLTGNQGFFLTKLAYVKVSNPYARYGRLYELIISDYDGYNKHVVLRQTDNPIATPSWSNDGRYIVYSSYSGGSMGVYTLEIATGKVTRITNYKGINSSPSFSPDGKEIALALSKGYSDQTNIYIMNLSTKALKRITINGINTAPKFSPNGQSIVFTSDREGRPNIYVASVNSKYPQSSILSTKIHQAYEPNYTPDGKNIVFMNQSSRTSGTQIADFNLANGSVTNITNGKADSSPTVSPYGDMVAYISTNTRGYSSLDMVSLDGDNHFNIETADNGNILIQSPSWSPKNF
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: SPP2B_HUMAN
Sequence: MAAAVAAALARLLAAFLLLAAQVACEYGMVHVVSQAGGPEGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVALLSYKDMLDIFTRFGRTVRAALYAPKEPVLDYNMVIIFIMAVGTVAIGGYWAGSRDVKKRYMKHKRDDGPEKQEDEAVDVTPVMTCVFVVMCCSMLVLLYYFYDLLVYVVIGIFCLASATGLYSCLAPCVRRLPFGKCRIPNNSLPYFHKRPQARMLLLALFCVAVSVVWGVFRNEDQWAWVLQDALGIAFCLYMLKTIRLPTFKACTLLLLVLFLYDIFFVFITPFLTKSGSSIMVEVATGPSDSATREKLPMVLKVPRLNSSPLALCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRVYFVACTIAYGVGLLVTFVALALMQRGQPALLYLVPCTLVTSCAVALWRRELGVFWTGSGFAKVLPPSPWAPAPADGPQPPKDSATPLSPQPPSEEPATSPWPAEQSPKSRTSEEMGAGAPMREPGSPAESEGRDQAQPSPVTQPGASA
What is the function of this protein?
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane.  Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595).  Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951).  May play a role in the regulation of innate and adaptive immunity (PubMed:16829952).  Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).
What are the official names of this protein?
Signal peptide peptidase-like 2B, SPP-like 2B, SPPL2b, Intramembrane protease 4, IMP-4, Presenilin homologous protein 4, PSH4, Presenilin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22B family.
Protein: PUR9_LACLS
Sequence: MSKRALISVSDKEGIVEFAKKIQELGWEIISTGGTKAVLDQEEIPNIAIDEVTGFPEMMDGRVKTLHPLIHGALLGRRDLDSHMKSLAEHHISPIDLVVVNLYPFKETLLAGGSQAEMIEKIDIGGPSMLRSAAKNHAAVTVVCDPMDYEKVEKELSADGETSLELRQQLAAKVFRHTASYDALIAQYLTEEFPVEDTKPEKLTLTYDLKQGMRYGENPQQSADFYESGLPTTYSIAQSHQLHGKELSYNNVRDADAALQIARDFDEPTVVALKHMNPCGIGTAKNIEQAWDYAYEADPVSIFGGIIVLNREVTEETAQKMSKIFLEIIIAPSYSKEALEILSKKKNIRLLTVDFSKKEQSEKEALVTGVLGGLLVQNQDVIVENPKEWTVATKVQPTDRQMEAMKFAWKAVKFVKSNGIIVTNDHQTLGVGPGQTNRVGSVKIALEATADKDALLQENAVLGSDAFFPFADNIDEIAKAGIKAIVQPGGSVRDQEVIEACDKYGIAMVFTGLRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: LOLB_PSEF5
Sequence: MFLRHFIVFSFIALLAGCAGFGARESVQGQGNPAQWRLHKDQLTGLDGWQINGKIGIRAPKDSGSGTLFWLQRQDYYDIRLSGPLGRGAARLTGRPGQVSLEVANQGRYESASPETLLEEQLGWKLPVSHLAWWVRGLPAPDSKSRLTLDGDSHLASLEQDGWQVEYSSYSQQNGYWLPERIKLNGSDLDVTLVIKEWLPRKLGQ
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: SSUD_RHOPT
Sequence: MTAPQTPSSNFLWFLPTHGDGHYLGTSNGGRDVNFGYLRQIAQAADQLGYFGVLLPTGRSCEDSWVVASAVAPWTERLRYLVAVRPGLQSPSVAARMTATLDRVIGGRLLVNVVTGGDPVENKGDGVFLSHDERYEVTREFLNVYSDLLSGKTVNVAGKHITIEDGRLLFPPVQSPRPPLYFGGSSDAGIDVAADTVDKYLTWGEPPAQVAEKVNRVRAVAEQRGRKLSFGIRLHVIVRETNEAAWAAADDLIRYVTDDTIAAAQKVFARMDSVGQQRMSELHGGRRDKLEISPNLWAGVGLVRGGAGTALVGDPQTVAARIKEYQDVGIDTFILSGYPHLEEAYRFAELVFPLVKSLHAGNVTPLRANTGPFGETIANEHLPNAKQAVKP
What is the function of this protein?
Catalyzes the desulfonation of aliphatic sulfonates.
What are the official names of this protein?
Alkanesulfonate monooxygenase, FMNH2-dependent aliphatic sulfonate monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the SsuD family.
Protein: DDL_XYLFA
Sequence: MFGRVAVLLGGTSAEREVSLLSGRNVLEVLRVRGVDAQSVDGVPALAQALVERRFDRVFNVLHGHNGGGEDGVVQGLMQAFGVPYTGSDVLGSALSMDKVRTKQVWLALGLPTPRYASLSVCATAVEVRQAVEMLGFPVIIKPAKEGSSVGVSRVFALEHLEEAVALAARYEGELLMEQLIEGDELTVSILDEMALPSIRIVPQGQWYDYNAKYLAEDTQYVCPGLDDVAEAEIARLALAAFRAVGCRGWGRVDVMRERGSGRFFLLEVNTAPGMTTHSLVPKAASQLGMGFDDLVWRILEQTL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBJH_ECOLI
Sequence: MIMKNCLLLGALLMGFTGVAMAQSVTVDVPSGYKVVVVPDSVSVPQAVSVATVPQTVYVAPAPAPAYRPHPYVRHLASVGEGMVIEHQIDDHHH
What are the official names of this protein?
Uncharacterized protein YbjH.
Protein: COG1_ARATH
Sequence: MRMSSASAGEYRPSAVSLSSNGGGQRDAESLFRTKPMSEIRIVESATRKNIEDKKEELRQLVGTRYRDLIDSADSIVHMKSLCESISANISSIHGNIRSLSSSSVAETPKLASLNPVRVNVYGIACRVKYLVDTPENIWGCLDESMFLEAAGRYMRAQHVQQRLIKLEGCGGGVAEVDQSKLLANFPLLEHQWQIVESFKAQISQRSHERLLDPGLGLGAYVDALTAVAVVDELDPEQVLELFLDSRKTWILQKLNACTGEDAGEVVLVFCDVLSVIQVTVGQVGELFLQALTDMPLFYKTILSTPPASQLFGGIPNPEEEVELWKSFRDKLESVMLILDKNDVSKSCLTWLRECGGQIVGKVSGKHLIEAIVTGAELGSAEKLIRETMDSKDVLRGSLDWLKSVFGSEVELPWNRIRELVLGDDLNLWDEIFEKAFVERMKSIIDSKFENLTKAVNVADSVHAYSEITGEKINFQAYLNRPSTGGGVWFIEPNSKKVGLISGNKSSPEESDFQSCLTAYFGPEVSQMRDAVDRRCHSVLEDLLSFFESEKAGPRLKDLAPYVQNKCYDSVSALLADVDKELEFLCAAVKKENKDSEAIPPAIIIEKSLFMGRLLFALLNHSKHVPLILGSPRLWCRETMTAVSDKLSSLLRQPRFSSNTPATADSPGKQLHTDLRKQTSLAVAALLGAEEKTSPKFEELNRTMRDLCIKAHTLWIKWLSDELSAILLRDLRSDDGLSATTPLRGWEETIVKQEQDESQSELKISLPSLPSLYMISFLCRASEEIHRIGGHVLDRSILQKFASSLLEKITIIYEDFLSAREASEPQISEKGVLQILLDLRFAADVLSGGDTSTNVETPKSTINRSAYRRRQDQQKTKLVNRGRIDGVTSQLTQKLDPIDWLTYEPYLWENEKQSYLRHAVLFGFFVQLNRMYTDTAQKLSINIESNIMPCSTVPRFKYLPISAPALSSRSTNKVSIPVTSNDASARNSWKAFTNGEQSQTSDLEENSNFGVAFKSFMQESTLKLGSILTDGQVGIFKDRSAAAMSTFGDILPAQAAGLLSSFTNTRSE
What is the function of this protein?
Required for normal Golgi function.
What are the official names of this protein?
Conserved oligomeric Golgi complex subunit 1, COG complex subunit 1, Component of oligomeric Golgi complex 1.
What is the protein family that this protein belongs to?
Belongs to the COG1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.