PharMolix/UniProtQA huggingface dataset:
Protein: SPI2B_HUMAN
Sequence: MKTPNAQEAEGQQTRAAAGRATGSANMTKKKVSQKKQRGRPSSQPRRNIVGCRISHGWKEGDEPITQWKGTVLDQVPINPSLYLVKYDGIDCVYGLELHRDERVLSLKILSDRVASSHISDANLANTIIGKAVEHMFEGEHGSKDEWRGMVLAQAPIMKAWFYITYEKDPVLYMYQLLDDYKEGDLRIMPESSESPPTEREPGGVVDGLIGKHVEYTKEDGSKRIGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKKS
What is the function of this protein?
Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692).  Exhibits H3K4me3-binding activity (PubMed:29061846).
What are the official names of this protein?
Spindlin-2B, Spindlin-like protein 2B, SPIN-2, SPIN-2B.
What is the protein family that this protein belongs to?
Belongs to the SPIN/STSY family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FENR1_BACP2
Sequence: MTEQLELFDVTIIGGGPAGMYTAFYSGMRDLKTKVLEYNESLGGKILLYPEKVIWDVGGLPPTRGEQLIQQLEKQAKTFEPEIALNQKITSFERDEHQNILLTAENGDRHLTKTLILAMGHGIPVQRKLEIEHADRYEVTNLYYTVQELKTFAGKRVVISGGGDSAVDWANALVPIAESVTVVHRRDMFGGHEKNVANMKASCARILTPHELTDLHGQGDKIDAVTIQHLETGEIERIETDAVIVNHGMKGDLSVLSEWGLKQGEWGLIEVNEKMETNLPGVYAVGDLCTHKSKVRLIAGTFVDGVNALNSAKLYIEPEAEKVAYVSSHNERFKEKNKELQTVGAR
What are the official names of this protein?
Ferredoxin--NADP reductase 1, FNR 1, Fd-NADP(+) reductase 1.
What is the protein family that this protein belongs to?
Belongs to the ferredoxin--NADP reductase type 2 family.
Protein: CCN2_BOVIN
Sequence: MSATGLGPVRCAFVLLLALCSRPASSQDCSAPCQCPAGPAPRCPAGVSLVLDGCGCCRVCAKQLSELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYQSGESFQSSCKYQCTCLDGSVGCVPLCSVDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKEHTVVGPALAAYRPEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA
What is the function of this protein?
Major connective tissue mitoattractant secreted by vascular endothelial cells.  Promotes proliferation and differentiation of chondrocytes (By similarity).  Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity).  Enhances fibroblast growth factor-induced DNA synthesis (By similarity).
What are the official names of this protein?
CCN family member 2, Cellular communication network factor 2, Connective tissue growth factor.
What is the protein family that this protein belongs to?
Belongs to the CCN family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: SPEE_CHRVO
Sequence: MHPFRRRVRPAVEAMPEVEISEEGNIRSLHLGSETIQSSMDLDDPPDLVLSYSRAMMGFLLWNDDPKHILQIGLGGGSFARFIDEYLPDAVSVAVDINPQVIAVARAFFQLPEEGDFFEIVEADGADYVKIFRGSTDAILVDGFDGLQIVDALTTEDFFEDCKRALSPKGVFVTNWWSGDKRYQSFIERLLNVFEGRVIELPAATHGNVAVMAFRQSPSLTQWEALRKRADELEGRFGLEFGEFVNRLKQTNQQTAGHLLI
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL5_SHEB5
Sequence: MAKLHDKYQETVVAELAKKFGYTSVMQVPRIEKITLNMGVGEAVADKKIMDHAVRDMTAIAGQKPVVTVARKSVAGFKIREGYPIGCKVTLRGERMWEFLERLVDIAIPRIRDFRGLSAKAFDGRGNYAMGVREQIIFPEIDYDKIDKIRGMDIVITTTAKNDEEGRALLDAFNFPFKK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: YR638_MIMIV
Sequence: MTDNNIMNLLNEDCILHILSFLADKDKIQLSLSCKSNLKFLHKTIYDDIYFYSKIKHLSYYHRFKYVVQDTMDDIDPQPSNIKWYILPAHYTNYAIGIRRQYNVYIKMDDTIVDENKIEKFIDKYTYDPYKYLD
What are the official names of this protein?
Putative F-box protein R638.
Protein: RLX2_SALTM
Sequence: MSDEIKQIAALIGHHQALEKRVTSLTEQFQAASSQLQQQSETLSRVIRELDSASGNMTDTVRKSVSSALTQVEKELKQAGLAQQKPATEALNQAADTAKAMIHEMRREMSRYTWKSAIYLVLTIFFVLASCVTAFTWFMNDGYSQIAEMQRMEAVWQKKAPLADISRCDGKPCVKVDTRTTYGDKENTWMIIKK
What is the function of this protein?
This protein is probably required for relaxation complex formation.
What are the official names of this protein?
22 kDa relaxation protein.
Protein: ASP23_STAS1
Sequence: MAVDNNKAKQAYDNQTGVNEKEQEQRQEQQNQQPEFTNKLSFSDEVIEKIAGIAAREVSGILEMKGGFVDNISSSFGSNNNVSQGVSVEVGEKQAAVDLKVVLEYGESAPKIFRKVTDLVKEQVKYITGLDVVEVNMRVEDVMTKKEWSQKNEKSQSSNNEDKGLQ
What is the function of this protein?
May play a key role in alkaline pH tolerance.
What are the official names of this protein?
Alkaline shock protein 23.
What is the protein family that this protein belongs to?
Belongs to the asp23 family.
Protein: DNLJ_THEAB
Sequence: MDKKKFKEEIEKLREEIEYHNYRYYVLADPVISDEEYDKLLKKLIELEKKYPEFYSPTSPTQKVGGKVLDGFKKVMHSIPMLSLDNTYNEEEIKEFDERIKKLLGVNEVEYVCELKIDGISVALRYENGQFVTALSRGDGIEGEDISENVKKIKSIPLRLFKNLTIEVRGEIFMPVKEFEKYNKIAEEEGLQPFANPRNATAGTIRQLDSSIVAKRNLDSFIYYVVNPEIYGLKTQWEALKFLKEIGFKTNPYSRLCHDVNCVIDFWKEMTKKRTQLDYWIDGLVIKVNNFEYQRKLGETAKAPRWAIAFKFPSIKAESKILNIELNVGRTGVITPVAVLEPINLEGSIVKRASLHNFDYIKEKDIRIGDHVYVEKAGGIIPQIVSVIKEKRTGKELEIEIPKSCPICGGKVGKISEEEVAIRCLNPHCPQKLKRHMEIFVSKSAFNISGLGEKIVEKIVDARLINDVADIFYLTPFDLAQISGLGQKSIANILEQIEKAKNTPLYRVIIGLGIPLVGEKTAKILADKFKSIKALSQASYDELTSIEGIGPEVAKNIIEYFKNEKTKEIIRKLENAGVKLEQEEDTKKSSKLAGLTFVITGKFNSFTREEVKEIIEKLGGKVTNTVSSKTDYLLVGEKPGSKYQKALELGVKIINEDEFKKMIID
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DER_TERTT
Sequence: MIPTIALVGRPNVGKSTLFNRLTKTRDAIVANFAGLTRDRKYGDAEFEGKRFIVVDTGGISGDEEGIDSVMAEQSLQAIAESDIILFLVDCRDGLTHVDSQIAQHLRTLHKPTFLVANKVDGQNHDLAIAPFFELGLGEVHSVAAAHGRGVNTLMATVLADIAVESEADEADAERRLKMAIIGRPNVGKSTLVNRMLGEERVVVFDMPGTTRDSIYIDYERDEKHYTLIDTAGVRRRKNVKLTVEKFSIIKTLQAINDANVVILVMDASEGIVDQDLHLLGHAIESGRALVVALNKWDGLEDDHKSYVKTELQRRLSFVDYADLHFISALHGTGVGNLYKSVEKAYQAATEKYSTSFLTRILEDAVTAHQPPLVRGRRIKLRYAHAGGHNPPIIVIHGTQTSEVPNHYTRYLEKVYRRALELHGTPVRIEYRSGDNPFAGRKNKLTERQLTKKRRLMKHVKKKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: LPXD_LEPBP
Sequence: MTQIKLSTLQTLLPDATFQNSETLKDINFSGLTSLTLAGPSDISFVASKTFVNEAKASKASLLVVSQETAEALSDKAIIIVSKVELTTAKIIRLFFPEKQPSGKRSAQVAIDPSAKIGSNTDIGHFVTIGKDSIIGNDCIIEDGVKIGDRVQIGDGARIGKNCVFFDDTIVGKRFIAFGNSTFGGDGFGFVYAEGKHNKIPQVGRVVIGDDVEVGSNCTIDRGALTDTTIGNGCKFDNMVHVAHNCKVGDHVIIAGQSGLAGSVTLGNNVIIGGACAISDHLTLVDGTIIAGGSSLRTSPKTKDVYVGWDLGLTFPEFQKYRVNIKNIVNLNKWLKRIENIEKKVGIETKES
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: ARCSA_THEKO
Sequence: MEVIKHEGPGRLGVVRLGDYSFRTPALVGIDFTLSPFNSFFHPKEPGEYDFNLAPSIPLGFYTPDEVIQKAIGRLWSVNYDGFNAFYLPALRRTEYLEEFFKIIDRHNFDAVYLGNSKILIKEYRYFVRILRELRERFPNVMIIADLEPFFYPLAVYLGIDAFDTRSLKLYDFEGKGFTQFSPFLWSNEPNSLDFAREVILLVRKALEEGKLRYLVENFFPTQYNAGILRIADLEHPDYLEKYTPIQKETVYFISDASIRRPEVKRWHERVLERFTPPKNVELLLLFPCSAKKPYSFSRSHTLYRRAVKEALGSGTSKVHELILTSPFGVVPREWEWLAKYDIVVTGHWSEEEIKPAAELLAKTLEKYPEDIPIVAHLDEAYVEIAKLASELSGREIIFTDVKNGTTSHESLRSLTETLREFQIEGTKEDRTYRYFENIRKVFDFYFGVGAGEAILPENGQVKGSKMLRIFVEGQQTGTFTDGVISVTPYGMQRIYDALKSYWVKIDFELRGDVFAVGVEEADPRIRPDDIVGIVRDEKVVGVGKAVLSGEEMVRAKKGVAVKVRKRV
What is the function of this protein?
Functions in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs.  Catalyzes the addition of L-lysine to the cyano group of 7-cyano-7-deazaguanine (preQ0)-modified tRNAs at position 15, to generate q0kN15-tRNA, a q0N lysine adduct identified as 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine.
What are the official names of this protein?
Archaeosine synthase subunit alpha, Archaeosine synthase, lysine transferase subunit.
What is the protein family that this protein belongs to?
Belongs to the archaeosine synthase type 1 family.
Protein: ATG8_VANPO
Sequence: MKSSFKSEYPFEKRKTESERITEKFQNRIPVICEKAEKSDIPEIDKRKYLVPSDLTVGQFVYVIRKRIMLPPEKAIFIFVNDTLPPTAALMSAVYQEHKDKDGFLYVTYSGENTFGSL
What is the function of this protein?
Ubiquitin-like modifier involved in autophagosomes formation.  With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Participates also in membrane fusion events that take place in the early secretory pathway.  Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
What are the official names of this protein?
Autophagy-related protein 8, Autophagy-related ubiquitin-like modifier ATG8.
What is the protein family that this protein belongs to?
Belongs to the ATG8 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Vacuole membrane; Lipid-anchor.
Protein: RX_MOUSE
Sequence: MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKEDGILDTFPAERSSRSSKERDPRLGAQPACPKAPAGGSESSPPAAPGFVPEYEATRPCYPKEQGEARPSPGLSVGPAAGDSKLSEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSSALAPLGTGPGSGSGPPGSALPLEPWLGPPLPGGGATALQSLPGFGPPGQGLPASYTPPPPFLNSAPLGPGLQQLGPPPAYPCAPAFGDKFSLEEAYPRNSSIAALRLKAKEHIQAIGKPWQAL
What is the function of this protein?
Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation.  Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity).
What are the official names of this protein?
Retinal homeobox protein Rx, Retina and anterior neural fold homeobox protein.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: ARVC_RAT
Sequence: MEDCNVHSAASILASVKEQEARFERLTRALEQERRHVALQLERAQQPGMSSGGMVGSGQPLPMAWQQLVLQEQSPGSQASLATMPEAPEVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPLGPDGLPLLDGGPPLGSFADGPLDRHYVLRGGGPAATLSRAYLSSGGGFPDGPEPRDIPSYGSLSRGLGVRPPRTGLLGPGPGDGCFTLPGRREAFPMGSESGPPSGRSLPEHFQAEPYGLEDDTRSLAADDEGGPDLEPDYSTATRRRPEYGRGLRARALEDTADDTGELVEERPPFPAATAPLAQPERGSLGSLDRVVRRSPSVDSTRKEPRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGIKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDADNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEVEPGIPGSAATSQRRRKDDASCFGGKKAKGKKDAEADRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDQRNKDLIGSYAMTELVRNVRNAQAPAHPSAHLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPALVALVASSQSVREAKAASHVLQTVWSYKELRGALQRDGWTKAHFQSASTAKGPKGTPNSGGFDDSTLPLVDKNLDGEKSTTRDVIPMDTLGPDGYSTVDRRERRTLGSDSIGDSSEKELLKGPGPAVCSSDHMEVIGRGPSGTDPVLGPGAPPFCVGLAKPLVYLALPSSLLS
What is the function of this protein?
Contributes to the regulation of alternative splicing of pre-mRNAs.
What are the official names of this protein?
Splicing regulator ARVCF, Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog.
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Nucleus. Cytoplasm. Note=In heart, localizes at area composita, the mixed-type junctional structure composed of both desmosomal and adherens junctional proteins.
Protein: TSAD_STRR6
Sequence: MKDRYILAFETSCDETSVAVLKNDDELLSNVIASQIESHKRFGGVVPEVASRHHVEVITACIEEALAEAGITEEDVTAVAVTYGPGLVGALLVGLSAAKAFAWAHGLPLIPVNHMAGHLMAAQSVEPLEFPLLALLVSGGHTELVYVSEAGDYKIVGETRDDAVGEAYDKVGRVMGLTYPAGREIDELAHQGQDIYDFPRAMIKEDNLEFSFSGLKSAFINLHHNAEQKGESLSTEDLCASFQAAVMDILMAKTKKALEKYPVKTLVVAGGVAANKGLRERLATEITDVNVIIPPLRLCGDNAGMIAYASVSEWNKENFANLDLNAKPSLAFDTME
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS1H_BACSU
Sequence: MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGIIPISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETKEVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKNRVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQLSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVLEGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENEERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK
What is the function of this protein?
Plays a role in sporulation.
What are the official names of this protein?
30S ribosomal protein S1 homolog.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS1 family.
Protein: HPRK_MACCJ
Sequence: MITSIELIDKFDLKFIAGNVAIEIPVANADISRPGLEMAGFFSHYSSDRIQILGTTEMSFFETLSKEERAERMVKLCRKETPCIILTRNIPAPQELIDACNRKGTPLLQSKEATTSLISKITSYLESELAPETTMHGVLVDVYGVGVLITGDSGVGKSETALELVKRGHRLVADDNVEIKEVSRNVLMGKAPKLIEHLLEIRGLGIINVMTLFGAGSVLPEKRLMLNINLETWNKDKVYDRIGLIEEKLSILDSQITKKTIPVRPGRNLAVIIEVAAMNYRLNKMGTNTAKDFNERQNEQIRRQSIKEI
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: SPT6_CANGA
Sequence: MSDQESASLREEKNEIINGMGSGAPSDEEEGEDVFDSSEEEEEDDEDEARKISEGFIVNDEDEDEDEDDENVADKKKKRRHKRRAREEEDDRLSEDDLDLLMENAGVKRPTTEGSSGGKLKRLKRVGDEVESGAADREQESSQEKESSRLNDFFSDDEDEEPYDEENRERSRGSREYDRGESNHQGDNRKSGMLDELDDFIEEDEFSDEDEETRQQRLLERKMMREQRMKAPTKITGLSSDKIDEMYDVFGDGHDYDWALEIENEELEGGDINEQSEEFDEETGMTKSSKKKISLQDIYDLQDLKKNLMTDEDMLIRKTDIPERYQELRSGLVNHGNLSDNDQELEKNWISEKIAVDKNFSADYDLTEFKEAVGNAIKFITKENLEVPFIYAYRRNYISSRERDGFLLTEDDLWEIVHLDIEFQSIINKRDYVKRFYSELGISDPLVDEYFKNQSTGSVAELNSLQDIYNYLEFKYAQEINDNLQKESDKSGKKHLKNSNYEKFKSSALYKVIEAVGVSADQIGNNISSQHQIHIPKDHEALKPLELIELVLNENAGDLQVFLSNIKLAMDTIQKYYSWEISKNTKVREKVRADFYRYYLVDVVLTTKGKREIQRGSLYEDIKYAINRTPLHFRREPEIFLKMLEAESLNLMTLKLHMSSQKQYVDHLFQIALETTNTSDLAIEWNNFRKAAFTQAIEKIFNDIAQEIKDDLEKTCQKLVCKVVRHKFMTKLDQAPYVPDLKDPKLPKILTLTCGQGRFGSDAIIAAYVNRKGEFVRDFKITENPFDRSNPDKFEEVFEDIVQTCQITAIGINGPNPKTQKLFKKLIEVIHKKNLVDSKGTHIPIIYVEDEIAIRYQNSERAAQEFPNKPPYVKYCIALARYMHSPLMEYANLSPEELKSLSIHPFQSFLSPEYLNRAIETAFVDIVNLVGVEVNKATDNSYYASVLRFVSGFGKRKAIDFLESLQRLNEPLLARQQLITHNILHKVIFMNSAGFLYISWSKKRQRYEDLEHDQLDSTRIHPEDYHLATKVAADALEYDPDTIAEKEENGTMSEFIEFLREDPNRRSKLESLNLESYAEELEKNTGQRKLNNLNTIVLELLDGFEELRNDFHIMQSEEVFSSLTGETDKTLFKGCVIPVRVERFWHNDIVCVTNSEVECIVNAQRHLGAQVRRPPNEIYELNKTYPAKVIFIDYPNITAEVSLLEHDVKNEYNPLTYSKDPAIWDLKQELEDSEEEKKVTMAESRAKRTHRVINHPYYFPFNGKQAEDYLRSKERGDFVIRQSSRGDDHLAITWKLDKDLFQHVDIQELEKENPLALGKVLVVEGQRYHDLDQIIVEYLQNKIRLLNELTSNEKFKAGTKKEVVKFIEDYSKVNPKKSVYYFSLNYENPGWFYLIFKLNAESKLYIWNVKLTHTGFFLVNYNYPTVIQLCNGFKTLLKSSNTRNRSGYR
What is the function of this protein?
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters.  Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
What are the official names of this protein?
Transcription elongation factor SPT6, Chromatin elongation factor SPT6.
What is the protein family that this protein belongs to?
Belongs to the SPT6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: F222B_MOUSE
Sequence: MLACLPGPGDLSLQLLSHTQMNTGLQKWDTTQKMRTAHYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHVRRTVNGLDTSAQRYSPYPTQAATKAGLLAIVKVPAKSILKDFDGTRARFLPEAIMNPPVAPYATVAPSTLAHPQAQALARQQALQHAQTLAHAPPQTLQHPQGIPPPQALSHPQSLQQPQGLGHPQQMAQTQGLVHPQALTHQGLQHPPNPLLHGGRKMPDSDAPPNVTVSTSTIPLSMAATLQHSQPPDLSSIVHQINQFCQTRAGISTTSVCEGQIANPSPISRSLLINASTRVSTHSVPTPMPSCVVNPMEHTHAATAALPAAGPVNLPTGISRAPTGYPSDLKPVTWNQHQLAHLQQMCSEAGGTPAPGLTGKHTAGRELAGPGFVGKAAAYPQELCLAQSFHLKPPLEKPTPSPPVNGLPAPLAYPNGHYFQPLWNNILPTPNSDSSGSQDLTMPFHGGQPTGAPLDCGAAPGAHYRAGTGGGPVASQNSLMQTVDYLSGDFQQACFREQSLAMLSKAHRAPGTRAPDPTDSRSLHIQHPGYR
What are the official names of this protein?
Protein FAM222B.
What is the protein family that this protein belongs to?
Belongs to the FAM222 family.
Protein: RSMG_STRS2
Sequence: MKPEVFYKTLADQGIQLTDQQKHQFHRYFQLLVEWNEKINLTAITEESEVYLKHFYDSIAPLLQGHIQNEPLRLLDIGAGAGFPSLPMKIIFPQLDVTIIDSLNKRINFLHLLAEELELEGVHFYHGRAEDFAQDKNFRAQFDLVTARAVARMQILSELTIPYLKLHGKLIALKASSAEDELTQAKNALNLLFAKVIENHDYTLPNGDPRTLTIVEKKKETPNKFPRKAGMPNKRPL
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_LACJO
Sequence: MNPEIFAKELAKYGFELNEKQKKQFATYYDKLVEFNKKVNLTRITDKNEVYLKHFFDSITPLLEFPDLFKGEKTLCDVGAGAGFPSLPIKILCPNLSITIVDSLGKRLKFLDELVNDLGLDKVTLVHSRAEDAGQNKDLREKFDLVTGRAVARMSVLSEYCLPLAKVGGYLVALKGPKAQDELAEAKHAIDVLGGKVEDVKELTLPDTDDDRTLIVVEKIKATPKKYPRQAGTPNKKPL
What is the function of this protein?
Specifically methylates the N7 position of a guanine in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_COREF
Sequence: MVSVTTKILILGSTGSIGTQALEVIADNPDLFTLVGIAAGGSNPGLVIEQARAFNLRPHQVAVAGKQAAGEVGEALGGTVIDGPDAAQTLVESVQATDPADAVLNALVGSMGLGATLATLRSGAHLALANKESLVAGGEFVMAQARPGQIIPVDSEHSAMAQCLRSGTEGEVARIVLTASGGPFRGWTREQMWEVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDTDADLIDVTVHPQSIIHSMITFRDGCTIAQASPPSMKLPIALAMNWPHRVPGAQPALDFTQAHTWTFEPVDDAAFPAVQLARDVAKQKGTFPAVYNAANEEAAAAFLAGRIRFPQIVDVVSEILQGASQFAGVSSDVDDILATESEARARANQLIDRLAR
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: NUOH_MYCVP
Sequence: MTYPDPTLFGHDPWWLVLAKSLGIFAFLLLTVLAAILIERKVLGRMQLRFGPNRVGPHGLLQSLADGVKLALKEGLVPAGVDKWIYLAAPIISVIPAFMAFAVIPMGGEVSVFGHRTALQLTDLPVAVLYILAVTSIGVYGIVLAGWASGSVYPLLGGLRSSAQVISYEIAMALSFAAVFIYAGTMSTSGIVAAQNDTWYIVLLLPSFLVYVTAMVGETNRAPFDLPEAEGELVGGFHTEYSSLKFAMFMLAEYVNMTTVSALATTLFLGGWHAPWPISIADGANSGWWPLLWFTVKVWLFLFFFMWLRATLPRMRYDQFMALGWKILIPVSLGWIMIVAITHSLRDQGYQAPATAAIGLAVAAVILLALLGRSRLRARRIRPEPIRPAGDGAFPVPPLPVKTRALEDADA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone (By similarity).
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.