PharMolix/UniProtQA huggingface dataset:
Protein: TF2H5_CHICK
Sequence: MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDLDETHVFVLAELVNFLQERVGELMDQNSFPITQK
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
What are the official names of this protein?
General transcription factor IIH subunit 5, General transcription factor IIH polypeptide 5, TFB5 ortholog, TFIIH basal transcription factor complex TTD-A subunit, TFIIH subunit p8.
What is the protein family that this protein belongs to?
Belongs to the TFB5 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CULP2_MYCTU
Sequence: MNDLLTRRLLTMGAAAAMLAAVLLLTPITVPAGYPGAVAPATAACPDAEVVFARGRFEPPGIGTVGNAFVSALRSKVNKNVGVYAVKYPADNQIDVGANDMSAHIQSMANSCPNTRLVPGGYSLGAAVTDVVLAVPTQMWGFTNPLPPGSDEHIAAVALFGNGSQWVGPITNFSPAYNDRTIELCHGDDPVCHPADPNTWEANWPQHLAGAYVSSGMVNQAADFVAGKLQ
What is the function of this protein?
Induces interferon-gamma (IFN-gamma) release in animal models and in human TB patients (PubMed:9673225, PubMed:10076913).  Also induces a strong delayed-type hypersensitivity (DTH) response in animal models (PubMed:9673225).
What are the official names of this protein?
Probable carboxylesterase Culp2, CFP25, Cutinase-like protein 2, Culp2.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Secreted. Cell surface.
Protein: CD44_RAT
Sequence: MDKVWWHTAWGLLCLLQLSLAQQQIDLNITCRYAGVFHVEKNGRYSISRTEAADLCEAFNTTLPTMAQMELALRKGFETCRYGFIEGHVVIPRIHPNAICAANNTGVYILLASNTSHYDTYCFNASAPLEEDCTSVTDLPNSFDGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNIIDEDVSSGSTIEKSTPEGYILHTDLPTSQPTGDRDDAFFIGSTLATIATTPWVSAHTKQNQERTQWNPIHSNPEVLLQTTTRMTDIDRNSTSAHGENWTQEPQPPFNNHEYQDEEETPHATSTTWADPNSTTEEAATQKEKWFENEWQGKNPPTPSEDSHVTEGTTASAHNNHPSQRMTTQSQEDVSWTDFFDPISHPMGQGHQTESKGHSSGNQDSGVTTTSGPARRPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGTVEDRKPSELNGEASKSQEMVHLVNKEPTETPDQFMTADETRNLQSVDMKIGV
What is the function of this protein?
Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment.  Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection.  Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases.  Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
What are the official names of this protein?
CD44 antigen, Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, Phagocytic glycoprotein I, PGP-I.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli.
Protein: COC2A_CONCL
Sequence: DVCDSLVDGRCIHNGCFCERDAPNGNCCDTDGCTARWWCPGTKWD
What is the function of this protein?
Mu-conotoxins block voltage-gated sodium channels.  This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity).
What are the official names of this protein?
Mu-conotoxin-like Cal 12.1.2a, Conotoxin CalTx 12.1.2B.
What are the subcellular locations of this protein?
Secreted.
Protein: RK33_PINKO
Sequence: MAKSGDIRVTITLECTSCTQDSVYKRFPGISRYTTRKNRRNTPIRLESNKFCPYCYKHTIHGEIKKRD
What are the official names of this protein?
50S ribosomal protein L33, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL4_LISIN
Sequence: MPKLSLLKQDGTNAGEITLNDTVFGIEPNEKVVVDVILSQRASLRQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYAYKLPKKVRRLAIKSILSSKVNEEKLVVLEGLTFDAPKTKEFAAFLKNISVDTKALIVVAGESENVELSARNLQGITVIPAESISVLEVAKHDKLIITKAAVEKVEEVLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: ACKA_HAEIG
Sequence: MSKLVLILNCGSSSLKFAILDPATGEEKLSGLAEAFFLPEARIKWKLNGEKGNADLGAGAAHTEALNFIASNILNDELKNSIAAIGHRIVHGGEKYTQSVIVTDEVVKGIEDAAQFAPLHNPAHLIGIREAFKAFPHLKDKNVVVFDTAFHQTMPEEAFLYALPYSLYKEHGVRRYGAHGTSHYFVSREVAEYVGKPADQVNAIICHLGNGGSVSVVRNGQCIDTSMGLTPLEGLVMGTRCGDIDPAIVFYLYKTLGMSMDQIEETLVKKSGLLGLTEVTSDCRYAEDNYDDESKPETKRALNVYSYRLAKYIGAYMAVLGDDHLDAIAFTGGIGENSAHVRELALNHLKLFGIKIDHERNLATRFGKDGVITTDDSAFKAIVLPTNEELVIAQDTAKLCF
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRAP_ECOLC
Sequence: MKNLIAELLFKLAQKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRDYVKKLLKHPRQ
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraP.
What is the protein family that this protein belongs to?
Belongs to the IraP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_RICPU
Sequence: MTTQKIVPTKSTDGSKLFRHQAKFVAGAMNINQIPNFSLPEIAFVGKSNVGKSSLINTICNNKNLAKVSNTAGRTRQINFFNLADKLIIVDLPGYGFANVPISVKEQWGVLISYYLRNSYNLRLVNLLIDSRRGIKENDKKVADLLLANKREFQIIFTKSDKVTDHKNLHDEAHNFLATLNYSCNVMYVSNRSKEGARELKASLAKCIKPQK
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: DAPB_BURP0
Sequence: MKIAIAGASGRMGRMLIEAVLAAPDATLAGALDRTGSPQLGQDAGAFLGKQTGVALTDDIERVCAEADYLIDFTRPEGTLAHLDAALRHDVKLVIGTTGFSEPQKAQLRAAGGKIALVFSANMSVGVNVTMKLLEFAAKQFAQGYDIEIIEAHHRHKVDAPSGTALMMGETIAAATGRTLDDCAVYGRHGVTGERDPSTIGFSAIRGGDIVGDHTVLFAGIGERIEITHKSASRVSYAQGALRAARFLAGHQAGFFDMQDVLGLR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDHD_SHIDS
Sequence: MENGKMNSLIAQYPLVKDLVALKETTWFNPGTTSLAEGLPYVGLTEQDVQDAHARLSRFAPYLAKAFPETAATGGIIESELVAIPAMQKRLEKEYQQPISGQLLLKKDSHLPISGSIKARGGIYEVLAHAEKLALEAGLLTLDADYSKLLSPEFKQFFSQYSIAVGSTGNLGLSIGIMSARIGFKVTVHMSADARAWKKAKLRSHGVTVVEYEQDYGVAVEEGRKAAQSDPNCFFIDDENSRTLFLGYSVAGQRLKAQFAQQGRIVDADNPLFVYLPCGVGGGPGGVAFGLKLAFGDHVHCFFAEPTHSPCMLLGVHTGLHDQISVQDIGIDNLTAADGLAVGRASGFVGRAMERLLDGFYTLSDQTMYDMLGWLAQEEGIRLEPSALAGMAGPQRVCASVSYQQMHGFNAEQLHNATHLVWATGGGMVPEEEMNQYLAKGR
What are the official names of this protein?
D-serine dehydratase, D-serine deaminase, DSD.
What is the protein family that this protein belongs to?
Belongs to the serine/threonine dehydratase family. DsdA subfamily.
Protein: LPLT_ECOL5
Sequence: MSESVHTNTSLWSKGMKAVIVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHILVALAACALAYGGAVVANIYIPKLAAARPGQSWNLISMTRSFLNACTSLWRNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFSLQHELLPAYALLMLIGVLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGIYSLAVMVGIPVVPIGIGFGALFALAITALWIWQRRH
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DPOL_HBVE4
Sequence: MPLSYQHFRRILLLDEEAGPLEEELPRLADEDLNRRVAEDLNLQLPNVSIPWTHKVGNFSGLYSSTIPVFNPHWKTPSFPDIHLHQDIINKCEQFVGPLTVNEKRRLNLVMPARFFPISTKYLPLEKGIKPYYPDNVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELHHGAFLDGPSRMGEESFHHQSSGIFSRPPVGSSIQSKHQKSRLGPQSQQRPLDRSQQGRSGSIRAGVHSPTRRPFGVEPSGSRHAKNIASRSASCLHQSAVRKAAYPNHSTFERHSSSGHAVEFHNIPPSSAGSQSKRPVFSCWWLQFRNSEPCSDYCLSHLVNLLEDWGPCTEHGRHHIRIPRTPARVTGGVFLVDKNPHNTAESRLVVDFSQFSRGSSRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHLPLHPAAMPHLLVGSSGLSRYVARLSSNSRIINHHYGTLPNLHDSCSRNLYVSLMLLFKTFGRKLHLYSHPIIMGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHLESLYTSVTNFLLSLGIHLNPNKTKRWGYSLNFMGYVIGSWGSLPQEHIRIKIKDCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQSKQAFTFSPTYKAFLCKQYLNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGVCRPLLRLPFQPTTGRTSLYAVSPSVPSHLPDRVHFASPLHVAWRPP
What is the function of this protein?
Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids.  This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode.  Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid.  Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein.  Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome.  After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).  The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
What are the official names of this protein?
Protein P.
What is the protein family that this protein belongs to?
Belongs to the hepadnaviridae P protein family.
Protein: YMF31_MARPO
Sequence: MVNLTVGNKNKSFTDQVGGFEWARIQLPESCGNGIFCTNTCYNNKGKRVAPGPVKLKHFWP
What are the official names of this protein?
Uncharacterized mitochondrial protein ymf31, ORF61.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS13_VIBPA
Sequence: MARIAGINIPDQKHAVIALTAIYGIGKTRSQAILAEVGIAEDVKISELTEEQIDQLRDGVAKYTVEGDLRREVSMNIKRLMDLGCYRGLRHRRSLPLRGQRTKTNARTRKGPRKPIKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SSP1_YEAST
Sequence: MRSSGTYENDPSGEITSTSPKQSKQKKPTKFRERMRRWLQNGKNNNHQGEEDVPEIFNKNFYPQTGMTAFNNNDNGEVQDVTNNFFLPSEDESGPVQSSVKTFLTGNNDEDSNFQQNQNPKQKSELPKSPYRQKPTQEIALLKDLFVTNKYDDPYLNSSTRFGNITSTFPSSLSLRTVTLQTIKKRIDCISAKKKEVWKTEEKFLKDILMWLQSSNFEDPDTISLIHEIEKIFEEDIHFEQNVSDCLKEISNNFEYICMRETQLINEGNILKNDLKKYAKAREHKGEKHEDTEVLREKVISSQKSFDVTKRHYKHAISITTRQLFMNLAFEYYENCSDMKDISRKYLQESLSTLQTIDTLSFSEELEKIRKRRFDKFWAKTNPDPTNNIQKFVNMRTGVAGFNDSLMNHLYGKLSFGVAPVEEELQNSQPEHTDVPENVWNEVLSDYNSMDGNPITSNKFLSAKELEPDQLVELLAQEKEEKEAKNISSSTAEVPSISQPEIKKENLESNDSLILRSTKRNVNVNAASLRNLSIKKTQVKPESASEESKVLAAALNDAKQNLDENVWRTPI
What is the function of this protein?
Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation.  May be required for the formation of ADY3 and DON1-containing protein coats at the leading edge of the PSMs during meiosis II.
What are the official names of this protein?
Sporulation-specific protein 1.
What are the subcellular locations of this protein?
Prospore membrane. Note=Localizes to precursors of the PSM and to the leading edge, which cover the ring-shape opening of the PSMs during meiosis II. Some fraction colocalizes with DON1.
Protein: RS14_BUCBP
Sequence: MAKQSMKAREVKRIKLAKKFYSRREHLKSIISDLSVLEQDRWKAVLKLQTFPRDSSPIRQRNRCSQTGRPHAFLRKFGLSRIKVREAAMRGEIPGLKKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: LOL3_ORYSJ
Sequence: MQSQIVCHGCRSVLRYPSGAPSVCCALCQAITTVPPPAPVMEMAHLICGGCRTLLMYTRNADTVRCSCCSTVNLVRPVNNIAHVSCGQCRTTLMYPYGAPSVKCAICHYITNTGMNTVAPTPSPMPTSSGSSYNAPPSGSSYNAPPPTSAPTSRPQNVTVVVENPMTVDEKGKLVSNVVVGVTTGK
What is the function of this protein?
Putative zinc finger that may be involved in programmed cell death and defense response.
What are the official names of this protein?
Protein LOL3, Protein LSD ONE LIKE 3, OsLOL3, Putative zinc finger LOL3.
What are the subcellular locations of this protein?
Nucleus.
Protein: LSPA_ERWT9
Sequence: MSKPVLSTGLRWLWLVLVVIAIDFVSKQWIMNNLMLHESMPVMPFFNFFYAHNYGAAFSFLADKGGWQRWFFAGIAVAIVVVLLVMMYRSKASDRLNNIAYALIVGGALGNLFDRAYHGFVVDFIDFTIGDWHFATFNIADCGICIGAALIVLEGFINPTSKRSEHKG
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MDTJ_ECO24
Sequence: MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV
What is the function of this protein?
Catalyzes the excretion of spermidine.
What are the official names of this protein?
Spermidine export protein MdtJ.
What is the protein family that this protein belongs to?
Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y970_MYCTO
Sequence: MIHDLMLRWVVTGLFVLTAAECGLAIIAKRRPWTLIVNHGLHFAMAVAMAVMAWPWGARVPTTGPAVFFLLAAVWFGATAVVAVRGTATRGLYGYHGLMMLATAWMYAAMNPRLLPVRSCTEYATEPDGSMPAMDMTAMNMPPNSGSPIWFSAVNWIGTVGFAVAAVFWACRFVMERRQEATQSRLPGSIGQAMMAAGMAMLFFAMLFPV
What are the official names of this protein?
Uncharacterized protein MT0998.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS5_GEOKA
Sequence: MRRIDPNKLELEERVVAVNRVAKVVKGGRRLRFSALVVVGDKNGHVGFGTGKAQEVPEAIRKAIEDAKKNLIEVPIVGTTIPHEVIGHFGAGEIILKPASEGTGVIAGGPARAVLELAGISDILSKSIGSNTPINMVRATFDGLKQLKRAEDVARLRGKTVEELLG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: MAD3_YEAST
Sequence: MKAYAKKRISYMPSSPSQNVINFEEIETQKENILPLKEGRSAAALSKAIHQPLVEINQVKSSFEQRLIDELPALSDPITLYLEYIKWLNNAYPQGGNSKQSGMLTLLERCLSHLKDLERYRNDVRFLKIWFWYIELFTRNSFMESRDIFMYMLRNGIGSELASFYEEFTNLLIQKEKFQYAVKILQLGIKNKARPNKVLEDRLNHLLRELGENNIQLGNEISMDSLESTVLGKTRSEFVNRLELANQNGTSSDVNLTKNNVFVDGEESDVELFETPNRGVYRDGWENFDLKAERNKENNLRISLLEANTNLGELKQHEMLSQKKRPYDEKLPIFRDSIGRSDPVYQMINTKDQKPEKIDCNFKLIYCEDEESKGGRLEFSLEEVLAISRNVYKRVRTNRKHPREANLGQEESANQKEAEAQSKRPKISRKALVSKSLTPSNQGRMFSGEEYINCPMTPKGRSTETSDIISAVKPRQLTPILEMRESNSFSQSKNSEIISDDDKSSSSFISYPPQR
What is the function of this protein?
Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.  Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20.
What are the official names of this protein?
Spindle assembly checkpoint component MAD3, Mitotic MAD3 protein.
What is the protein family that this protein belongs to?
To yeast protein kinase BUB1 in its non-catalytic N-terminal domain.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTX4_GRARO
Sequence: MKTSVVFVIAGLALLSVVCYASELKEQSSVNEVLSTIFHFEQPEERGCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSFGK
What is the function of this protein?
This cationic hydrophobic peptide acts on a lot of different channels and has an antimicrobial activity.  It blocks mechanosensitive ion channels (also named stretch-activated channels or SACs), without having effect on whole-cell voltage-sensitive currents.  It also affects acetylcholine receptors (nAChRs) through interactions with membrane lipids by prolonging the closing time without affecting channel conductance or opening activity (PubMed:34374321).  It shows high affinity for lipid bilayers (PubMed:15241420, PubMed:29703751).  It acts by partitioning into the membrane and perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel.  It inhibits atrial fibrillation as well as the membrane motor of outer hair cells at low doses.  It also binds to the voltage sensor of voltage-gated potassium channels from the archaebacterium Aeropyrum pernix (KvAP) without affecting channel gating.  It shows also a low inhibition on a large spectra of sodium channels (Nav1. 1/SCN1A, Nav1. 2/SCN2A, Nav1. 3/SCN3A, Nav1. 4/SCN4A, Nav1. 5/SCN5A, Nav1. 6/SCN8A, Nav1. 7/SCN9A) (IC(50)=7. 4-14 uM), and potassium channels Kv11. 1/KCNH2 and Kv11. 2/KCNH6 (IC(50)=11 uM for both) (PubMed:19955179, PubMed:29703751).  It exhibits antimicrobial activities against the Gram-positive bacteria B. subtilis (MIC=0. 5 uM), S. aureus (MIC=2-4 uM), and S. epidermidis (MIC=4-8 uM), and Gram-negative bacteria S. typhimurium (MIC=32. 64 uM), P. aeruginosa (MIC=8-16 uM), and E. coli (MIC=8-16 uM).
What are the official names of this protein?
M-theraphotoxin-Gr1a, M-TRTX-Gr1a, GsMTx-4, GsMTx4, MTx4, GsMTx-IV.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 52 (MTx4) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: AB8A_ARATH
Sequence: MADSSPASFLTQADALLRKNLVFQKRNIWSNIRLITIPFFLCLLLLVIQMLFDTQFNDVHGQCGCNEKTCGLRYSTSEQAAFCAIPNPPQWTPLLQIPAPEYRAAIPYPSHTSPATFLFTGNNQSLGNILMGNMYSNSSGFDGDLAYYVLGSSSFPAYTNHMDSAFISDLPIYNIQHECSPNSSFSILIHQSPLAFPKEVNCVQGLNLWRNSSSDVNNELFKGYRKGNPDKKINEFAGAFDFQNTNGNNLNVSVWYNSTYKNDTVVRPMALIRVPRLVNLASNAYLEFLKGSETKILFEYVKEMPKPETKLSLDIASLIGPLFFTWVILLLFPVILTTLVYEKQQRLRIMMKMHGLGDVPYWIVSYTYFLLISILYMLCFAIFGSLIGLNFFRLNDYSIQLVFFFICINLQISVAFLASAMFSDVKTATVIAYIYVFGTGLLGIFLFQFFLEDPLFPRGWIIAMELYPGFSLYRGLYELSQSAFAGDYRGIDGMKWRDFGNGMKEVTCIMLIEWLLLLGLAYYIDQIIYSRKHPLFFLLQSTSKKKQHFSDNKISKVVVEMEKPDVCREREKVEQCLLKSTRDSAVLCNNLKKVYSGKDGNPQKLAVRGLSLALPQGECFGMLGPNGAGKTSFINMMTGIIKPSSGTAFVQGLDILTDMDRIYTTIGVCPQHDLLWEKLSGREHLLFYGRLKNLKGSVLTQAVEESLRSVNLFHGGIGDKQVSKYSGGMKRRLSVAISLIGSPKVVYMDEPSTGLDPASRKSLWDVVKRAKRKGAIILTTHSMEEAEILCDRIGIFVDGSLQCIGNPKELKSRYGGSYVLTVTTSEEHEKEVEQLVHNISTNAKKIYRTAGTQKFELPKQEVKIGEVFKALEKAKTMFPVVAWGLADTTLEDVFIKVAQTS
What are the official names of this protein?
ABC transporter A family member 8, ABC transporter ABCA.8, AtABCA8, ABC2 homolog 7.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCA family. CPR flippase (TC 3.A.1.211) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RI15A_CRIRI
Sequence: MKIIVVLAVLMLVSAQVCLVSAAEMGHSSDNELSSRDLVKRFFLPPCAHKGTCGKRSIESSEGANGGE
What are the official names of this protein?
Riparin-1.5 amide.
What are the subcellular locations of this protein?
Secreted.