PharMolix/UniProtQA huggingface dataset:
Protein: NUSB_SYNJB
Sequence: MQPRRIARELALLGVNQLPATAAKLSEKQLEDLLLAAIRALSEETHETLSTAAAEIQRSDRLLHESDPLLLADSDPKEEGGSRSVTLRLHQAQRHLQRLEITLKEAKVPNPNALRGEVLELIQQVQVALSNAGQALEHLEQRLHSVRHILDEVVQLSQRAVNRVGVALSMPELLYIAQSQEVRAYALQLLTALRTHKEAIDARLQKALVGWQLQRVGRIERDILRLAVVEMEILASSPVKVAINEAVELAKKYGDPEAAAFVNGVLRRVVDSQMETHRGRDPSLPGSGSGG
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: GATA_SYNR3
Sequence: MPIGAWSDALRNGSATAKEHSEQALERIAATEPELKAFVNVTGDQARAQAEAVDQAIAAKQDPGPLAGVTIGIKDNLCTKGVTTTCSSRMLENFVPPYESTVTERLWKAGAVMVGKTNLDEFAMGSSTETSAFGMTSNPWDPGRVPGGSSGGSAACVAAGQCDVALGSDTGGSIRQPASFCGVVGLKPTYGRVSRWGLVAFASSLDQIGPFSRTVADSAAVLQVIAGHDPRDSTSLDVPVPDYSAALNRPIQGLKIGILQEAFVEGLQPEVEASVRAAAEQLASLGCELVDVSCPRFQAGIATYYVIAPSEASANLARYDGVKYGYRAADAESLSAMTAKSRAEGFGDEVQRRILIGTYALSAGYVDAYYKKAQQVRTLIRQEFDRAFEQVDLLLTPTAPTTAFTPGEHSNDPLAMYLADLLTIPANLAGLPAISVPCGFDGQGLPIGLQLMAPVLQEERLLQVAHHYEQAADVMANRPEAPLVA
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: Y261_HALH5
Sequence: MTEKGYPSADAYEKELLSLLETVRYQAKQDTTLQIAERMLDYGVDVQLTAAVTGLTRDEILSGKRGKIPLQVKVK
What are the official names of this protein?
Uncharacterized protein BH0261.
Protein: RSMA_STAAB
Sequence: MLDNKDIATPSRMRALLDKYGFNFKKSLGQNFLIDVNIINNIIDASDIDAQTGVIEIGPGMGSLTEQLARHAKRVLAFEIDQRLIPVLNDTLSPYDNVTVINEDILKANIKEAVENHLQDCEKIMVVANLPYYITTPILLNLMQQDIPIDGYVVMMQKEVGERLNAEVGSKAYGSLSIVVQYYTETSKVLTVPKSVFMPPPNVDSIVVKLMQRTEPLVTVDNEEAFFKLAKAAFAQRRKTINNNYQNYFKDGKQHKEVILQWLEQAGIDPRRRGETLSIQDFAKLYEEKKKFPQLEN
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_CLAM3
Sequence: MANIKKGDLVQVITGRTQAKGGDRGKQGKVLSVLVERNRVVVEGVNFITKHVRVGQTQRGSKTGGIETVEAPIHISNVALVDPESKKPTRVGFRTEQVEKDGVSKTVRVRYAKKSGKDL
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: EVGA_ECOL6
Sequence: MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG
What is the function of this protein?
Member of the two-component regulatory system EvgS/EvgA.  Regulates the expression of emrKY operon and yfdX.  Seems also to control expression of at least one other multidrug efflux operon (By similarity).
What are the official names of this protein?
DNA-binding transcriptional activator EvgA.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OVGP1_MOUSE
Sequence: MGRLLLLAGLVLLMKHSDGTAYKLVCYFTNWAHSRPGPASIMPHDLDPFLCTHLIFAFASMSNNQIVAKNLQDENVLYPEFNKLKERNRELKTLLSIGGWNFGTSRFTAMLSTLANREKFIDSVISFLRIHGFDGLDLFFLYPGLRGSPPHDRWNFLFLIEELQFAFEREALLTQHPRLLLSAAVSGIPSIIHTSYDALLLGRRLDFINVLSYDLHGSWEKFTGHNSPLFSLPEDSKSSAYAMNYWRKLGTPADKLIMGFPTYGRNFYLLKESKNGLQTASMGPASPGKYTKQAGFLAYYEVCSFVQRAKKHWIDYQYVPYAFKGKEWLGYDDTISFSYKAMYVKREHFGGAMVWTLDMDDVRGTFCGNGPFPLVHILNELLVQTESNSTPLPQFWFTSSVNASGPGSENTALTEVLTTDTIKILPPGGEAMTTEVHRRYENMTTVPSDGSVTPGGTASPRKHAVTPENNTMAAEAKTMSTLDFFSKTTTGVSKTTTGISKTTTGVSKTTTGVSKATAGISKTIPEISKATAGVSKTTTGVSKTTTGISKTITGVSKTTTGISKTTTGISKTTTGVSKITTGVSKTTTGISKTTTGISQTTTGISKTTTDISKTTTGISKTTPGISKTTPGMTVIVQTQANEAETTATMDHQSVTPTEMDTTLFYLKTMTPSEKETSRKKTMVLEKATVSPREMSATPNGQSKTLKWASLITEVETYSQDG
What is the function of this protein?
Binds to oocyte zona pellucida in vivo.  May play a role in the fertilization process and/or early embryonic development.
What are the official names of this protein?
Oviduct-specific glycoprotein, Estrogen-dependent oviduct protein, Oviductal glycoprotein, Oviductin.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.
Protein: GUDD_ECO57
Sequence: MSSQFTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR
What is the function of this protein?
Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc).  Also acts on L-idarate (By similarity).
What are the official names of this protein?
Glucarate dehydratase, GDH, GlucD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.
Protein: DAPF_NITHX
Sequence: MGTLANHAFSKMNGIGNEIVVVDLRDRPAAVTAEEARAVASPGGVPYDQLMVLQPPRLPGTEAFVSIYNNDGSEANACGNGMRCVARQVFEATGKAALTFETRAGLLSCWQGPAPGLYTVDMGPPKFGWRDIPLAEEFRDTRYIELQVGPIDAPVLHSPSVVSMGNPHAIFWVDDVNAHDLERFGPLLENHPIFPERANITLAHIAGRDRIVMRTWERGAGMTKACGSAACATAVAAARLKRADRVVDMVLPGGGLTIEWRERDDHVLMTGPAVFEYAGTFDPALFASVA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NV5_NEMVE
Sequence: MNSLLKVAVVCLVMLVACSSGRVVLPDDADTEYNSEYALAKRVNCKCEGGHEEGTYWVFGCPKNWYSCKSGYVYGRCCSQQWGK
What is the function of this protein?
Has toxic effects on zebrafish larvae (PubMed:31134275).  It causes contractile paralysis and twitching of the tail within 20 minutes, followed by death within 30 minutes (PubMed:31134275).  Does not show any toxicity when injected into arthropods (cherry shrimps or grass shrimps) (PubMed:31134275).
What are the official names of this protein?
N.vectensis toxin 5, Nv5.
Protein: CITD_HAEIG
Sequence: MKITKVAVAGTLESSDVQVRVQPFDSLDIEINSSVAKQFGEQIEATVREVLAKLGITAAQVIVEDKGALDCVLQARVKAAAMRATDEMINWEAVL
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HDA17_ARATH
Sequence: MAFSMLFTGHAECVKFVKKFNLPLLVTGGGGYTKENVARCWTVETGILLDTELPNEISENDYIKYFAPDFSLKIPGGHIENLNTKSYISSIKVQILENLRYIQHAPSVQMQEVPPDFYIPDFDEDEQNPDVRVDQRSRDKQIQRDDEYFDGDNDNDAS
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.
What are the official names of this protein?
Histone deacetylase 17.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECR_NOCFA
Sequence: MYEGPVQDLIDELGKLPGVGPKSAQRIAFHLLQVEPPEIDRLQAALQKVRDGVQFCVVCGTVSDGELCRICADPRRDRTMICVVEEPKDVQAIERTREFRGRYHVLGGALDPLSGVGPDQLRIRELLARIGNQDDGVDVAEVIIATDPNTEGEATATYLVRMLRDFPGLTVTRLASGLPMGGDLEFADELTLGRALSGRRAL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: GLYCO_RABVA
Sequence: MVPQVLLFVPLLGFSLCFGKFPIYTIPDELGPWSPIDIHHLSCPNNLVVEDEGCTNLSEFSYMELKVGYISAIKVNGFTCTGVVTEAETYTNFVGYVTTTFKRKHFRPTPDACRAAYNWKMAGDPRYEESLHNPYPDYHWLRTVRTTKESLIIISPSVTDLDPYDKSLHSRGFPGGKCSGITVSSTYCSTNHDYTIWMPENPGPRTPCDIFTNSRGKRASKGNKTCGFVDERGLYKSLKGACRLKLCGVLGLRLMDGTWVAMQTSDETKWCPPDQLVNLHDFRSDEIEHLVVEELVKKREECLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEIIPSKGCLKVGGRCHPHVNGVFFNGIILGPDGHVLIPEMQSSLLQQHMELLKSSVIPLMHPLADPSTVFKEGDEAEDFVEVHLPDVYKQISGVDLGLPNWGKYVLMTAGAMIGLVLIFSLMTWCRRANRPESKQRSFGGTGRNVSVTSQSGKVIPSWESYRSGGEIRL
What is the function of this protein?
Attaches the virus to host cellular receptor, inducing endocytosis of the virion.  In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane.  There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).
What are the official names of this protein?
Glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus glycoprotein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein.
Protein: HIFD2_HAEIF
Sequence: MQKTPKKLTALFHQKSTATCSGANYSGANYSGSKCFRFHRLALLACVALLDCIVALPAYAYDGRVTFQGEILSDGTCKIETDSQNRTVTLPTVGKANLSHAGQTAAPVPFSITLKECNADDAMKANLLFKGGDNTTGQSYLSNKAGNGKATNVGIQIVKADGIGTPIKVDGTEANSEKAPDTGKAQNGTVIQPRFGYFGSLLRHR
What is the function of this protein?
May be a minor structural protein required for pilus biogenesis.
What are the official names of this protein?
Minor fimbrial subunit HifD.
What is the protein family that this protein belongs to?
Belongs to the fimbrial protein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Fimbrium.
Protein: CI043_MACFA
Sequence: MDLPDESQWDETTCGFAVCQHPQCWATVRRIERGRPRILGSTCKTPLDAEDKLPVLTVVNISDSCFAPRHLPECTVTKARSLLSRSSKFYSKFHGRPPKGLPDKSLINCTNRLPKLPVLNLNETQLPCPEDVRNMVVLWIPEETEIHGRQHGKKKRKNLTVKSKSFLGLSGNQSAVTRVETPGMTVPPPTPVQLSKQFSSDFLPLWAQSEALPQDLLKELLPDRKQTMPCLEMKIKLAMMKKNLPLERNRPDSAISSKMFLSIHRLTLERPALRYPERLKKLHNLKTEGYRKQQQWQQQQQQRKVKTPIKKQEAKKKAKSDPGSQSTSHKHPVTTVHDPLYGYRTLPGQNGDMKQQQQMEKGTTSKQDSTERPKMDYCDHVDFHHNVKGPELYETEPTNKDISAPVEAVLKAQAARQKKISFNFSEIMVRTGWNSELKLLRILQETDDEDEENQYSEAEKPLEE
What are the official names of this protein?
Uncharacterized protein C9orf43 homolog.
Protein: IHFB_AGRRK
Sequence: MIKSELVQIVAARNPHLYHRDVENIVNAVLDEITDALAAGNRVELRGFGAFSVKNRPSRSGRNPRTGDTVFVEEKWVPFFKTGKELRERLNPGAGDEDDDDN
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: TSAM1_COMTE
Sequence: MFIRNCWYVAAWDTEIPAEGLFHRTLLNEPVLLYRDTQGRVVALENRCCHRSAPLHIGRQEGDCVRCLYHGLKFNPSGACVEIPGQEQIPPKTCIKSYPVVERNRLVWIWMGDPARANPDDIVDYFWHDSPEWRMKPGYIHYQANYKLIVDNLLDFTHLAWVHPTTLGTDSAASLKPVIERDTTGTGKLTITRWYLNDDMSNLHKGVAKFEGKADRWQIYQWSPPALLRMDTGSAPTGTGAPEGRRVPEAVQFRHTSIQTPETETTSHYWFCQARNFDLDDEALTEKIYQGVVVAFEEDRTMIEAHEKILSQVPDRPMVPIAADAGLNQGRWLLDRLLKAENGGTAP
What is the function of this protein?
Involved in the toluene-4-sulfonate degradation pathway.  Does not discriminate between the sulfonate and the carboxyl substituents and can also be involved in the p-toluenecarboxylate degradation pathway.  Can use toluene-4-sulfonate, p-toluate, m-toluate and 4-ethylbenzoate as substrates, but not p-xylene, toluene and p-cresol.  Catalyzes also the demethylation of 4-methoxybenzoate to 4-hydroxybenzoate.
What are the official names of this protein?
Toluene-4-sulfonate monooxygenase system iron-sulfur subunit TsaM1, TS methylmonooxygenase system, oxygenase M, Toluenesulfonate methyl-monooxygenase oxygenase component TsaM1.
Protein: POTA_FRAAA
Sequence: MTATSGARTSDARTSGARTSDAGIGSPAAIELVGVAKDYQTRGRAVPAVSRVDLAIRPGEFFSLLGPSGCGKSTTLRMIAGFEEPTRGRILLQGRDVTAVPPNRRDVNLVFQSYALFPHLDVAGNVAFGLRRRGVKGRELRERVGAMLDLVELSELADRRPRELSGGQQQRVALARALVNRPAALLLDEPLGALDLKLRQTMQIQLKAIQREVGITFLYVTHDQGEALTMSDRIAVMNGGRVEQLASPRDIYERPRTRFVAGFIGTSNLLRRTVRALDAAGPGGRPTVVLDAGTDERLSAPLHPPTGPLRAGDQVELTVRPEKIEMSVSRPDGPGCALRGRIVEVVYLGTYTTYTVATHGGTEITVFWQNSTGAGNVAERGDEIWLSWLPEHSYVLPEPVALPEPVALPGSVVPPETVNQPDSVGPPDSIIPPHSVVAPDSVDPRETVVPAAGTSADPAAYRISH
What is the function of this protein?
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Spermidine/putrescine import ATP-binding protein PotA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DLHH_METEA
Sequence: MTAFDADLRSLAAQTTLSRRTVIATSLATGFALAVQPVAAQTTIATDANGLIAGEVKIPMQDGVIPAYRAMPAEGGPFPTILVVQEIFGVHEHIKDVCRRLAKLGYFALAPELYARQGDVSTLTNIQQIVSEVVSKVPDAQVMSDLDAAVAFAKGTGKADTARLGITGFCWGGRITWLYAAHNPAVKAGVAWYGRLVGDSSALMPKNPVDVAADLKAPVLGLYGGADQGIPVATIDRMKEACRAAGKTCDFVVYPEAGHAFHADYRPSYRAEPAQDGWKRLQDWFRQYGVA
What are the official names of this protein?
Putative carboxymethylenebutenolidase, Dienelactone hydrolase, DLH.
What is the protein family that this protein belongs to?
Belongs to the dienelactone hydrolase family.
Protein: TRHO_ACHLI
Sequence: MQKNYRVLLYYKYTAIENPEKFKDEHLAYCKSQDLLGRILVSSEGINGTLSGTFEQTENYMDYLKSLQGFEDIFFKIDEVDAHAFSKMHVRVKKELVNLSLEDDVNPLEITGKYLEPIEFYQKLQDPNTVVIDARNDYEFDLGHFRGAIKPEIKNFRDLPDWIRENKDQFKDKEILTYCTGGVRCEKFSGWLIKEGFNVAGQLHGGIHNYGTSKDTEGKLWDGKMYVFDERIAVDINKHEHVVVGRDYFTNEPCERYINCGNPECNKQILASEASEEKYLGSCSHACRIHPNNRYVKKHNLTTDFVLQHIASNLETQI
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: YGIB_ECOL5
Sequence: MKRTKSIRHASFRKNWSARHLTPVALAVATVFMLAGCEKSDETVSLYQNADDCSAANPGKSAECTTAYNNALKEAERTAPKYATREDCVAEFGEGQCQQAPAQAGMAPENQAQAQQSSGSFWMPLMAGYMMGRLMGGGAGFAQQPLFSSKNPASPAYGKYTDATGKNYGAAQPGRTMTVPKTAMAPKPATTTTVTRGGFGESVAKQSTMQRGATGTSSRSMGG
What are the official names of this protein?
UPF0441 protein YgiB.
What is the protein family that this protein belongs to?
Belongs to the UPF0441 family.
Protein: MNMC_LEGPC
Sequence: MSSPFAPIITADIDWRDDLPYSLQFDDIYYSAEGGINQSLYVFVEGNNLINRWQQLPTNESNVFTIAETGFGTGMNFLLTWKLWEKFAPQNARLHYISCDKHPLKKNDLIKCLQKWPELSVQAEKLIEHYPVLTPGYHHLAFSNNQITLTLMLGDVLECYEQLLFCGDINLEQQLRESYVNAWYLDGFSPSKNQSMWSDNLLTVIAMLSKEGTTVATYSASSIVKTALTNAGFVIEKRKGFGPKRHMLCAYYEKAYSSSKKNRHTPWHINYPVTKDERTALIVGGGLAGCFIANSLAKRGWEVTILEEKEKVGCGGSANQQAVLFPKLSTYKSPFTQFMLYSFLYANDVYKELLKHYDLGELKGSLLLAHNEREKANQQSLIHWLELYPELGQLVDEKQSSELSGISLPCGGLFIPSSGWINSPELCDILIDNKRISLITGNRVQSINYNQKNWVVNDIEASVLILANGQQVNYFHETNHLPVKAIRGQITTIQSTQESTKLKIPLCAEGHVLPALNNSHRVGASYDIGTSEPELNALDDQLNLDRLKRIAPDIMWSQNVLDHWAGIRAASPDYLPIVGPLPNALEFKEVYSELKSNSKRWIAEAAPCYPNLYVCAAFGSRGLTTIPLATEWLAGLINKEISILPRKLIQAISPARFLRKKIIQGP
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSEL_SALPB
Sequence: MNICVNSLYRLSTPQFHSLYSEDVSDEALALLIGEVENGNQNCIDLLCNLALRNDDLGHKVEKLLFDLFSGKRSGSPDIDKKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGSATTDLSKKIGIAHKIMGDQFAQTDQEQVGVENLWCGARMLSSDELAAATQGLVQESPLLSVNYPIGLIHPTTKENILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLIFNTYYDLNENTKQEIIEAAKIAGISESDEVNFIEMNLQNNVPNGCGLFCYHTIQLLSNAGQNDPVTTLREFAEKFLTLSVEEQALFNTQTRRQIYEYSLQ
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells (By similarity).
What are the official names of this protein?
Deubiquitinase SseL, Deubiquitinating enzyme, DUB, Deubiquitinating protease, Salmonella secreted effector L.
What is the protein family that this protein belongs to?
Belongs to the peptidase C79 family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. In phagocytic cells localizes to the Salmonella-containing vacuole (SCV). In epithelial cells localizes to the Salmonella-containing vacuole (SCV) and to the Salmonella-induced filaments (Sifs), which are tubular membrane extensions from the SCV that are formed at late stages of infection (By similarity).
Protein: NHAA_SALPA
Sequence: MKHLHRFFSSDASGGIILIIAAALAMLMANMGATSGWYHDFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIGLEVKRELMQGSLASLRQAAFPVIAAIGGMIVPALLYLAFNYSDPVTREGWAIPAATDIAFALGVLALLGSRVPLALKIFLMALAIIDDLGAIIIIALFYTSDLSIVSLGVAAFAIAVLALLNLCGVRRTGVYILVGAVLWTAVLKSGVHATLAGVIVGFFIPLKEKHGRSPAKRLEHVLHPWVAYLILPLFAFANAGVSLQGVTMDGLTSMLPLGIIAGLLIGKPLGISLFCWLALRFKLAHLPQGTTYQQIMAVGILCGIGFTMSIFIASLAFGNIDPELINWAKLGILIGSLLSAVVGYSWLRARLNAPA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LIPA_ECO45
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G6PE_RABIT
Sequence: MKCPGVWGMLTVTMCVVFLGCPQAQELQGHVSVILLGATGDLAKKYLWQGLFQLFLDEAGKGHSFSFHGAALTAPKQGQELMAKALESLSCPRDMAPSRCAELQAQFLRLSRYRQLKTAEDYQALGRDIEAQVQQEGLREAGRMFYFSVPPFAYADIARNINSSCRPGPGAWLRVVLEKPFGHDHLSAQQLATELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRRALDSLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDTLQNHLTEILTLVAMELPANVSCSEAVLRHKLQAFRALRRLQRGSAVVGQYQTYSEQVRRELRKPAGSPSLTPTFAGVLVHVDNLRWEGVPFILMSGKALDERVGYVRVLFKNQAFCAQSEKHWAPAQSRCLPRQIIFYIGHGELGHPAVLVSRNLFRPFLPAQSWREVEDRPGLQLFGRPLSDFYAFSPVKERDAYSILLSHIFHARKESFVPTEHLLASWVFWTPLLESLAREVPRLYPGGADSGRLLDFEFSGSHLSFSLGQPEQLVPGPGSTPRPSDFQVLGAKYRESPLISAWPDELISKLASDIEAAAVQAVRRVGTFHLALSGGSSPIALFQQLASGHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRVPYYNIHPMPVNLHQRLCAEEDRGAQAYASEISALVTNCSFDLVLLGMGTDGHTASLFPQSPTGLDGEQLVVLTESPSRPHQRMSLSLPLINRAKKVAVLVMGRTKRDITLLVSRVGREPKKWPISGVLPTSGQLVWYMDYEAFLG
What is the function of this protein?
Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes.  Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway.  In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway.  May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate.  The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum.  By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity.
What are the official names of this protein?
GDH/6PGL endoplasmic bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: RHLB_SHEB5
Sequence: MSETHLSTQRFADLPLHPEVKQALAENGFEFCTPIQALSLPVLLQSKDIAGQAQTGTGKTMAFLVATFNHLLSTPVPEGRLINQPRAIIMAPTRELAIQIAKDAILLAKHTHLKVGIVYGGESYDVQRKVLDQGVDILIGTTGRIIDYVRQGIIGLNSIQAVVLDEADRMFDLGFIKDIRFLFRRMPEANQRLNMLFSATLSMKVQELAYDHMNEPVKVEIAPEEKTSKNIKEEIFYPSQEEKMRLLLTLIEEDWPEKAIVFSNTKHSCETLWSWLEGDGHRVGLLTGDVPQKKRIRILEQFTSGQLDILVATDVAARGLHISDVSHVYNYDLPDDCEDYVHRIGRTGRAGNKGMSISFACEEYALNLPAIESYINHSIPVSNYDSEALLADIPTPAKIHRKHPSGTRNLRDRSGTSRPGAQRSGARPPRHDRTRRHS
What is the function of this protein?
DEAD-box RNA helicase involved in RNA degradation.  Has RNA-dependent ATPase activity and unwinds double-stranded RNA.
What are the official names of this protein?
ATP-dependent RNA helicase RhlB.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. RhlB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.