PharMolix/UniProtQA huggingface dataset:
Protein: TFE_METST
Sequence: MAKKKVKYTFDYDSKFLNEHNVKKLAYELTHDSDTSNKILDCLFTAEVTDEQIAEATGIKLNFVRKILYKFYDVGMANYTRKKDPETQWFTYYWRFDSRKAAQILEKQYNHHNQEIKESIEYEENNMFFVCPNGCRYPFDEATEFQFICPRCNEKLEFKDNSDLIHDLKKLESAYKINE
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: SYSM_SCHPO
Sequence: MRLTNRRFSTFLGNALPSKKKGFIFMSQLLYLRTFSTHTSYLRSSWQAILNYKYIYQNAEAVQRNCINRNLQAIAETVPKIRSLIDEKESLKNEFFPLLSLKKEITLQIERCSDPNERGKLVNEAKGLKKKTEEYNKIISKVTNDLYQYCLAVPNTTLPTVPVGPEDKAVVVQKIGSPLVKKTGSLKDHLQIANEGINLEDAAQASGHSFCYTTGDIALLEMAITNYAMDFAISKGWCPVIPPTIVRTDIALACGFQPRDEEGQQIYELDSYTSPLVSSPKQCLIGTAEISLAALGFKKTFNNFTERKVVGVSRAYRREAGARGKENRGLYRLHEFTKVELFAWTHPSRSSEMFNEIVNFQKEFVETLKIPARILNMPTAELGSSASQKYDIEAWMPARQSYGEITSASNCLEYQARRLLTRYRNDKDSGFVHTLNGTAAAIPRLIIAILENHQQEDGTVKVPETLVPYIHKEYLFKAK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
What are the official names of this protein?
Serine--tRNA ligase, mitochondrial, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: GLYA_RICPU
Sequence: MNIFNNNLHETDKEINEIIKHEKLRQSNVIELIASENFVSPAVLEAQGALLTNKYAEGYPSKRFYNGCEEVDKAENLAIERVKKLFNCKYANVQPHSGSQANQAVYLALLQPGDTVLGMSLDSGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDYDEIERLADLHKPKLLIAGFSAYPRNIDFAKFREIVDKVGAYFMADIAHIAGLVATGEHQSPIPYAHAVTSTTHKTLRGPRGGLILSKDEEIGHKINSALFPGLQGGPLMHIIAAKAVAFLENLQPEYKSYIQQVISNAKALASSLQERGYDILTGGTDNHIVLVDLRKDGITGKLAANSLDRAGITCNKNAIPFDETSPFITSGIRLGTPACTTRGFKEKDFVLVGHMVADILDGLKNNEDNSALEQKVLNEVTKLIELFPFYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURQ_BACAA
Sequence: MKFAVIVFPGSNCDVDMFHAIKDELGEEVDYVWHDTENLDEYDAILLPGGFSYGDYLRCGAISRFANAMKAVQKAAEQGKPILGVCNGFQILVESGLLPGALMRNENLKFMCRTVQLRVENNETMFTSQYEKDEVINIPIAHGEGNYYCDEETLKQLEENNQIAFRYVENPNGSVSDIAGIVNEKGNVLGMMPHPERAVDELLGGAEGLKVFQSILKQWRETYVVNA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_ACIAD
Sequence: MPIFPKPKVTVILANLGTPDVPTASAVRAFLKQFLSDQRVIEIPKLLWKIILYSFVLPFRPKRVAHAYASVWGQDSPMREILFAQTDALKRQLISHYPQLDLNIVPAMTYGNPGVQHILKDLAASPQEHVILLPLFPQYSATSTAPLYDAFANWIPKQRHLPGLTIIKDYYRHPVFIQALVSSVQRFQQQHGKPQKLLMSFHGIPQPYADKGDPYADRCRETARLVAKQLGLTPDDWAISFQSRFGKQEWVKPYTDELLTTWAANGIKSVQILSPAFSADCLETLEELEIQNAELFLEAGGTSYQYIPALNTSVEHLELLRQLLQAHLDALNYSLAYSAH
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLPL6_CAEEL
Sequence: MLHYLLSVLLLIFENILELCMCITLVILIYYFWPSKQLEDATLQYFPDTTQNSSEVFIDPPERNPIFYPISPLRHKKRSSKEEMTPDKKRDSSEKISKQPPRELFEPNEQEQVPSHIKPEIFFVLKALEGLELPTTWQLDPKDVETLSIDTGSVVLSPGRANDVIVVVISGELGIFTNVSLGDKRYDCNIKTLRSGESYFSQTSIIEILMNEKPNNKYIHLKALTSCRVATYHLTSFHTSFIANPQQWIRTIQVVMTRLQQCTLITCNMYLGIGGKCLNAKRKLPDSGKFKDFNKLTEAEQLNKGVEAIAQAMGIPDQSDKLREKVRKYECQAGTVVTEENSFEIDMIFVVFGKLRLKRGDLEHDDTGTSLTFDVYPGDMLPSMQILTNEPAMCSAKALEKTIYFKICRDEYIQFLFAHPVIYLRLAFHALQFISPFARVFDMAVHWHRIETGQALFRQGDKSDSMHIVMGGRLRAVDSTKIIEEYGRLDLIGITDMAEKRPRRNTVMAVRFSHIVCIPENLLSFVKIRYPQVGNKLLKLISKCWKAPTPETMSHVETTRNQNLRTIAIVPASRRVPLTEFTCELYNQLSKHVKTLRLSSSVVENYFESEVITKKADYGLMHWLNVQEIAYSLVLYQCDFHKTNWTRRCLRMADAILMVALGTESKEEQVLAEALLSCNEKGVRQSKELVFLWPIDTPTPSGTAAWIKESYYSGYHHLRAPNRLFSFPLKTREKKIVEYYETTVYGEISYQSDFSRLARILTGNAIGIVFGGGGARGAAHAGALRALIEKKVQIDMVGGTSIGALFGSLYATTPDIRAVGRMKDFFTDRLRNNILDVVRDLTWPYCGILTGHRFNLCVQRMLNDVNIEDCWVSFFCITTDLTSSSMRIHRNGIMWPVVRSSMSIAGYVPPICDPQDGHLLLDGAYVNNLPADIMRSLGANVVIAIDVGMSDDNTNLRNYGFSISGTWCLFKRWWPFGEELRVLNMNEVQNRLAYVCCVNQMEIVKNAQYCYYVKLPIESFGIFDFSKFDQAAQIGYDITKQKMEEFFEDSVATRRKLLGCARNVRQTPQKSKNDNILSFVNMPVLPKPPSDIKSD
What are the official names of this protein?
Putative patatin-like phospholipase domain-containing protein M110.7.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: HIS51_LEGPH
Sequence: MSSVSIVDYGVGNLLSVARAFQYFDASVNLVSTPEEIMSADRLVLPGVGAFEDGMKGLTTLNFIEPIKQFARSGKPFLGICLGMQMMLSRSTEFGQHEGLDLIAGEVVSVPSHGVDGQLHKIPHIGWNELVSTSEGEDWCHTILKNIPLNSSVYFVHSFMAMPSNPKKRLADTLYDGQAISAVIKDENMYGCQFHPEKSGEVGLSIIQQFLQI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH 1, IGP synthase glutaminase subunit 1, IGP synthase subunit HisH 1, ImGP synthase subunit HisH 1, IGPS subunit HisH 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXX_NOCSJ
Sequence: MTYVGQSASAAQQSVAERASVKDVLAAYVGLTKPRVIELLLLTTVPVMFFADRGIPELWLVVATVVGGAFSAGSASVFNCVYDRDIDEQMRRTRRRALPRHIVSPAAALVFGFVLGILSTVILYVWVNPLSAALSVAANAFYVLVYTMLLKRRTTQNIVWGGLAGCFPALIGWTAVTGSLSWVPVVLFAVVFFWTPPHTWALALRYREDYANVDVPMLPVVAPAREVGRQVVIYSWVMVATSLLLWPVAGTGIFYPIAAGVLGAVFLLEAHRMWARSRDTESLSVIQPMRLFHSSNLYLSLLFVAVALDPLLAG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NSAR_BACCR
Sequence: MKITAIHLYAIRLPLRNPFVISYGSYSDMPSIIVKMETDEGIIGYGEGVADDHVTGESWESTFHTLKHTLTPALIGQNPMNIEKIHDMMDNTIYGVPTAKAAIDIACFDIMGKKLNQPVYQLIGGRYHEEFPVTHVLSIADPENMAEEAASMIQKGYQSFKMKVGTNVKEDVKRIEAVRERVGNDIAIRVDVNQGWKNSANTLTALRSLGHLNIDWIEQPVIADDIDAMAHIRSKTDLPLMIDEGLKSSREMRQIIKLEAADKVNIKLMKCGGIYPAVKLAHQAEMAGIECQVGSMVESSVASSAGFHVAFSKKIITSVELTGPLKFTKDIGNLHYDVPFIRLNEKPGLGIEINEDTLQELTVFQDIVR
What is the function of this protein?
Catalyzes efficient racemization of N-succinyl-L-Arg and N-succinyl-L-Lys, suggesting that these are physiological substrates of this enzyme.  Has low activity with L-Asp-L-Lys, and even lower activity with L-Leu-L-Arg, L-Leu-L-Lys, N-succinyl-L-His and N-succinyl-L-Met (in vitro).
What are the official names of this protein?
N-succinyl-L-Arg/Lys racemase, N-succinyl amino acid racemase, NSAR.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Protein: HYDRA_PAEAU
Sequence: MRILVINPNSSSALTESVADAAQQVVATGTIISAINPSRGPAVIEGSFDEALATFHLIEEVERAERENPPDAYVIACFGDPGLDAVKELTDRPVVGVAEAAIHMSSFVAATFSIVSILPRVRKHLHELVRQAGATNRLASIKLPNLGVMAFHEDEHAALETLKQAAKEAVQEDGAESIVLGCAGMVGFARQLSDELGVPVIDPVEAACRVAESLVALGYQTSKANSYQKPTEKQYL
What is the function of this protein?
Involved in the asymmetric conversion of racemic 5-substituted hydantoins to the corresponding L-amino acids.  Catalyzes the racemization via enolization of D- and L-5-monosubstituted hydantoins.  It shows preference for hydantoins with arylalkyl side chains such as 5-benzyl-hydantoin (BH) and 5-(3-indolymethylene)-hydantoin (IMH).
What are the official names of this protein?
Hydantoin racemase.
What is the protein family that this protein belongs to?
Belongs to the HyuE racemase family.
Protein: MDH_THETH
Sequence: MKAPVRVAVTGAAGQIGYSLLFRIAAGEMLGKDQPVILQLLEIPQAMKALEGVVMELEDCAFPLLAGLEATDDPKVAFKDADYALLVGAAPRKAGMERRDLLQVNGKIFTEQGRALAEVAKKDVKVLVVGNPANTNALIAYKNAPGLNPRNFTAMTRLDHNRAKAQLAKKTGTGVDRIRRMTVWGNHSSTMFPDLFHAEVDGRPALELVDMEWYEKVFIPTVAQRGAAIIQARGASSAASAANAAIEHIRDWALGTPEGDWVSMAVPSQGEYGIPEGIVYSFPVTAKDGAYRVVEGLEINEFARKRMEITAQELLDEMEQVKALGLI
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: CTPD_ASPNA
Sequence: MSNNNTQKPLPFGYQFIAGAVAGVSEILVMYPLDVVKTRVQLQKGTAVAGEEYYNGMFDCLRKIVKNEGFSRLYRGISAPILMEAPKRATKFAANDSWGAFYRNLFGAEKQTQSLAILTGATAGATESFVVVPFELVKIRLQDRASAGKYNGMLDVVKKIVAAEGPLAMYNGLESTLWRHILWNSGYFGCIFQVRAQLPAAEPGNKSQQTRNDLIAGTIGGTAGTILNTPMDVVKSRIQNTSKVPGQVPKYNWAWPAVGTVMKEEGFAALYKGFLPKVLRLGPGGGILLVVFTGVMDFFRNMRGE
What is the function of this protein?
Mitochondrial transporter that mediates citrate export from mitochondria to cytoplasm (PubMed:36177470).  Both ctpA, ctpB, and ctpD play important roles in citric acid transport across the mitochondrial membrane and function in a redundant manner (PubMed:36177470).
What are the official names of this protein?
Mitochondrial citrate transporter D.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
Protein: ACSA_BURP0
Sequence: MSAIESVLHERRQFAPPAAVEKAAAISGMAAYRALAEEAERDYEGFWARLARETLEWRKPFGKVLDETNAPFYKWFEDGELNASYNCLDRHVAAGLGERVAVIFEADDGTVTRVTYADLLARVSRFANALKKRGVGRGDRVVIYIPMSVEGIVAMQACARIGATHSVVFGGFSSKSLHERIVDVGATALVTADEQMRGGKTLPLKSIADEALAMGGCDAVKTVVVYRRTGGNVDWHAGRDVWMHEMVANESDACEPEWVGAEHPLFILYTSGSTGKPKGVQHSTAGYLLWVAQTMKWTFDWKPDDVFWCTADIGWVTGHSYITYGPLAVGATQVVFEGVPTYPNAGRFWKMIGDHKVTVFYTAPTAIRSLIKAAEADDRVHPRSYDLSSLRIIGTVGEPINPEAWIWYHKNVGQARCPIVDTWWQTETGGHMITPLPGATPTVPGSCTLPLPGIMAAVVDETGQDVPNGQGGILVVKRPWPAMARTIWGDPERFKKSYFPEELGGRLYLAGDGTVRDKETGYFTIMGRIDDVLNVSGHRLGTMEIESALVSHELVAEAAVVGRPDDTTGEAVVAFVVLKRSRPEGEEAAALAKTLRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSLAKGEAITQDTSTLENPAILEQLAEVR
What is the function of this protein?
Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways.  AcsA undergoes a two-step reaction.  In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.  In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
What are the official names of this protein?
Acetyl-coenzyme A synthetase, AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: SYFA_VEREI
Sequence: MNELDSLVESARQRFAQSTSPADLENAKAQFLGKSGRVTELMKGMAQLCVAEKKTRGAAINLAKQAIEAALNARRQALADAQLQQQLTADALDVSLPGRQRGQGGLHPVSLTLERIEGLFGSMGFDVADGPEIETDWFNFTALNTPEDHPARSMHDTFYVEGGTAGAPNLLRTHTSPMQIRHAVQHVKAHRAALDAGQPMPEIRVIAPGRAYRIDSDATHSPMFHQCEGLWIGENVGFKDLKVIFTGFCRRFFESDDLVLRFRPSFFPFTEPSAEIDIRFQTGPLAGRWLEVAGSGQVHPNVVRNMGLDPEKYIGFAFGMGLDRLTMLRYGVSDLRLFFDGDIRFLSQFR
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MHPB_ECOSE
Sequence: MHAYLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISTFGNWRSEGRYYRPIPEWIAGFGSLSARTEN
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: ARO1_USTMA
Sequence: MTSTASAQQPVLRTKTPSYHAPPSTDPLSGATIHTLRCLDTPIHLGYHLIPHIAKTLLSTLPSSTYVLITDQNLEARCSVTTAFRREFEKAAVHLSSSHSWRLLTKVIPPGEASKSRDGKNAIEDWMFEHRVTRDAVVLAVGGGVIGDLVGFVAATFMRGLKFVQIPTTLLAMVDSAVGGKTAIDHPLGKNLIGSFHQPNYVFIDAAWLKTLPVREFSNGMAEVVKTAAIWDPIDFAKLESSAPAIRSAVLGPFAKDAPLDQGRTLETRTESQSLLLDVIRGSVGVKAHIVTIDEKETGLRNLVNFGHTIGHAIEAVLTPEMLHGECISIGMILEAEVARYMHGLSQVAIGRLTRCLKEYDLPVSLSDSRVTRLAKSLDVTVDRLLDIMKVDKKNSGTNKKIVLLSSIGDTVQNMASTVSDHIIRRVLSLAATVTPIHEQPNKPKVTLSTPGSKSISNRALVLAALATNTCRLRNMLHSDDTQVMMAGLHDLQAARFEFEDGGETIVVHGNAGALARPANDKQIYLQNAGTAARFMATVVSLVHNDGNQHPVVITGNKRMKERPIAALVDALRSNGTSIDYLEGHGCLPLAVKGTTHGFKGGKIQLSATISSQYVSSILLCAPYAAEQVVLELVGGQVISQLYIDMTIAMMATFGIKVERLLDPTTGRPSNTYRIPKGHYVSPDVYDIESDASSATYPLAIAAITGTECTVPNIGSASLQGDARFAKEVLEPMGCTVVQTATSTTVIGPKLGQLRQIGLVDMEPMTDAFLTASVLLAVAAHSPANGSTSNARPSTRITGIANQRVKECNRIRAMMDELAKFGVNTKEHDDGLEIFGIDYRQLHANVRVHCYDDHRVAMAFSVLASLAPGAILEEKRCVEKTWPNWWDDLERKLGIRVHGVDPECSPSLCISPSHFTKASAASTNGKPPTCLSQLTCGKALTPRKYSKHATIICIGMRASGKTFLGAIGAAALSRTFIDADVVFNEKLGAKDGLGDFVREHGWPAFRQKELEILQELIARHPSGALISLGGGVVETEACRQILAEYAQTKGPVIYIVRDTNAIVKFLATSDRPAYGEPVMDVYRRRNPWFSECSSAELVSYSEGESLAIQPCAMNVPDPSFTIQKKFGLETEVARFFKFVVGQDTNQIRDLVVDSRKGGRRTYFLSLTFPDVVPKLELIRSMESGSDALEFRADLLNPSGQPVTTPQIPPTEYVKNQLAALRHRTSLPIVFTVRTHSQGGMFPDGKQHEYFELISLALRHACEYIDLELGWDDDLLSAVVQAKGNSQIIASWHDWSGRLDWESESTAKIYEKACRFGDIAKIIGKATTMEDNYSLERFRAKVSATATKPLLAVNMGSVGQLSRIVNPVFTPITHEAMPFKAAPGQLSFRQVQTALSLIGQADARRFALFGSPIGHSLSPLLHNTGFAALGLPHQYELLESTEINDAVAAFVRSPDFGGASVTIPHKLNIIKLLDEVTDEAKTIGAVNTIIPIRDAQGVVTSLVGDNTDWIAIETLARRSLRTVHLADPNLTGLVIGAGGSARAALFALYRLGVKRILLFNRTLANAEKLAREVPPEWNVSVLTSLDEVAQLSADQSPSVVVSNIPAEGSTLDASSRGLIHLPTCMLRNPAGGVVIDMSYKPHYTSLLQLAQQVNTNHELAIGTNATKAPTRKLWAAVPGITILLEQGCHQFHRWTGREAPRAQIEAAAWDVYLQRC
What is the function of this protein?
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
What are the official names of this protein?
Pentafunctional AROM polypeptide.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the shikimate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_NOSP7
Sequence: MLTVALPKGELLKNSIRLLQSVGLDFSAFLDSGTRQLQIPDTKGLAKALLVRAQDVPVYVEYGQAQLGVVGYDVLREKQPQVAHLVDLQFGYCRMSVAVKASSSYRSPLDLPPHGRVASKYVNCAREYFHSLDLPVEIVPLYGSVELGPITGMSEAIVDLVSTGRTMRENGLIEIATLYESTARLIAHPLSYRMNTGNLSDVIAKLREAVLVEV
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E4PD_SHEPC
Sequence: MIRVAINGYGRIGRSILRALYESGKRQQIQIVAINELAKPEAIIHLTQYDTTHGRFQHKVKLVDNHMLIGDDAIKILHEPDAAKLPWREMDIDIVYEATGVILDRQSCEAHIHAGAKQVLISHPSSADVDGTIVYGVNHDLLRAGHTVVSNASCTTNCIVPVIDVLDKHFGVKSGAITTIHSAMNDQQVIDAYHDDLRRTRAAGQSIIPVDTKLARGIERILPHMKDKFEAISVRVPTINVTAIDLSVTLAKTVDIASVNQVLELAANGRFNGILGYTDEPLVSCDFNHDPRSSIVDGTQTRVSAGQLVKLLLWCDNEWGFANRMLDTSLAMIAAKQS
What is the function of this protein?
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
What are the official names of this protein?
D-erythrose-4-phosphate dehydrogenase, E4PDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EZRA_STAAR
Sequence: MVLYIILAIIVIILIAVGVLFYLRSNKRQIIEKAIERKNEIETLPFDQNLAQLSKLNLKGETKTKYDAMKKDNVESTNKYLAPVEEKIHNAEALLDKFSFNASQCEIDDANELMDSYEQSYQQQLEDVNEIIALYKDNDELYDKCKVDYREMKRDVLANRHQFGEAASLLETEIEKFEPRLEQYEVLKADGNYVQAHNHIAALNEQMKQLRSYMEEIPELIRETQKELPGQFQDLKYGCRDLKVEGYDLDHVKVDSTLQSLKTELSFVEPLISRLELEEANDKLANINDKLDDMYDLIEHEVKAKNDVEETKDIITDNLFKAKDMNYTLQTEIEYVRENYYINESDAQSVRQFENEIQSLISVYDDILKEMSKSAVRYSEVQDNLQYLEDHVTVINDKQEKLQNHLIQLREDEAEAEDNLLRVQSKKEEVYRRLLASNLTSVPERFIIMKNEIDHEVRDVNEQFSERPIHVKQLKDKVSKIVIQMNTFEDEANDVLVNAVYAEKLIQYGNRYRKDYSNVDKSLNEAERLFKNNRYKRAIEIAEQALESVEPGVTKHIEEEVIKQ
What is the function of this protein?
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation.  Inhibits FtsZ ring formation at polar sites.  Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
What are the official names of this protein?
Septation ring formation regulator EzrA.
What is the protein family that this protein belongs to?
Belongs to the EzrA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Colocalized with FtsZ to the nascent septal site.
Protein: GLPK_FRAT1
Sequence: MSKDFILAVDQGTTSSRAIIFDKKGNIRKIAQKEFTQIYPKSGWVEHDAMEIWGTQSGVMREALEFGRVKPDQIAAIGITNQRETVVVWDKETGDPVYNAIVWQCRRTSSICDEIKRDPQFVKYIKENTGLVVDAYFSGTKVKWILDNVEGAREKANAGKLLMGTIDTWLIWNLTRGKVHATDYSNASRTMLFNINSLEWDKKILDYLNIPESMLPEVKNSSEVFGVTDSHTLGGAEIPIAGVAGDQHAALFGHCCFEKGMAKNTYGTGCFALMNVGDKPVYSDEGLLTTIAWAENGKPTYALEGSVFIAGAVIQWIRDGLGLVRSAEDSEYYATKIDSTNGVYLVPAFVGLGTPYWDMYARGTIVGITRDTKREHIIRAALEAIAYQAKDVLECMKEDTGLDLAGLRVDGGAVQNNFLMQFQSDILQSEISKPKVNEITGLGAVFLAGLAVGFWKDKQELKSILTTEKVFEPQKDSQAVAHDYRGWKKAVERSKAWAECYS
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: ISPD_HAEI8
Sequence: MTRSIIAVLPAAGVGSRMQADKPKQYLTLLGKTLLEHTLDVMLSYPAVSKIILAVSKDDPYISTLSLDPKIQLVEGGTTRAESVLNGLNAIAEKNAWVLVHDAARPCLQHADIDKLLAIEDKQGAILAIPVTDTIKRADNQQCIVKTEDRSQLWQAMTPQFFPVDILRDALSTGIQQGANITDEASAIELAGFRPHLVAGRSDNLKVTRPEDLALAEFYLTRNKL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: PCKA_ECODH
Sequence: MRVNNGLTPQELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLVTRQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGGEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDALLENVTVREDGTIDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEKAETLAKLFIDNFDKYTDTPAGAALVAAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_SINMW
Sequence: MEKNWFFPPHDGIRLGDLADQIGAELLDATAADRAVRAVAPVYRAKAGDVCYMLSRKSREELQTCSATAIICDKAISSLVPDTIPVLLTAKPHTAFALAGTLLHERAMRPSYNTSERGVSPGAFVDSTARLEAGVEVEPMAVIGAGAEIGSGTRIAAGAMIGPGVRIGRDCTISAGVSILCALIGNNVIIHPGTRIGQDGFGYAPGPTGGMIKIVQVGRVIIQDHVEIGANTTIDRGTMDDTVIGEGTKIDNLVQIGHNVRIGRYCGIVSQVGIAGSAQIGDGVMIGGGVGVNGHTSIGSGAQIAAMSGVASDVPAGERYGGIPARPMRDFLRDVAEMALRSSERQKKKGGKDE
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: FMT_BORA1
Sequence: MRLVFAGTPEFARLALEALLAAGHEIPLVLTQPDRPAGRGLKLTPSPVKEAALAAGIEVAQPRSLRLDGRYPDEALAAQARLVAVAPEVMVVAAYGLILPRWTLALPARGCLNIHASLLPRWRGAAPIQRAIEAGDARTGVTIMQMDDGLDTGDMLLERTVPIGAETTAAVLHDELARVGAEAIVAALADLPALAPRKQPEQGVTYAAKLDKAEAALKLDESAELLARRIRAFNPVPGASLRLPGLNEPVKVWQAEALPESSPAAPGTVLRASAQGVDIATGQGVLRLLELQKAGGKRQSAEVFVRGWQPA
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.