PharMolix/UniProtQA huggingface dataset:
Protein: CORI3_ARATH
Sequence: MATLKCIDWQFSGSEAAKDAAAASLGSYTSALYALCDPHGKPILPPRNEILETSNTAEKAVVKAVLYGSGNAYAPSLGLAAAKSAVAEYLNQGLPKKLTADDVFMTLGCKQAIELAVDILAKPKANVLLPSPGFPWDLVRSIYKNLEVRHYNFLPEKNFEIDFDSVRALVDENTFAIFIINPHNPNGNTYSEAHLKQLAELAKELKIMVVSDEVFRWTLFGSNPFVPMGKFSSIVPVVTLGSISKGWKVPGWRTGWLTLHDLDGVFRNTKVLQAAQDFLQINNNPPTVIQAAIPDILEKTPQEFFDKRQSFLKDKVEFGYSKLKYIPSLTCYMKPEACTFLWTELDLSSFVDIEDDQDFCNKLAKEENLVVLPGIAFSQKNWLRHSIDMETPVLEDALERLKSFCDRHSNKKAPLKDVNGVK
What is the function of this protein?
Possesses cystine lyase activity in vitro.  Does not possess tyrosine aminotransferase, alanine aminotransferase, aspartate aminotransferase and tryptophan aminotransferase activities.
What are the official names of this protein?
Cystine lyase CORI3, Protein CORONATINE INDUCED 3, Protein JASMONATE RESPONSIVE 2.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: AXA81_HUMAN
Sequence: MAWWKAWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP
What are the official names of this protein?
Annexin A8-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
Protein: DPCKG_METVS
Sequence: MYILTDKVATELKKPFGKVYKELNSIEGKVISIGDVTTKHLLSNGIVPDLSILDFKTKRNVPVEIPHKFKTVFEVYNPPGYISDEAIERIKYLSTIDDRDMALIVKGEEDLLTLPVIKYFPEDTSVIYGQPDEGMVVLKITKELKQKIEKLLKDMEER
What is the function of this protein?
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
What are the official names of this protein?
GTP-dependent dephospho-CoA kinase, Dephospho-coenzyme A kinase, DPCK.
What is the protein family that this protein belongs to?
Belongs to the GTP-dependent DPCK family.
Protein: HAKAI_HUMAN
Sequence: MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity).  Targets CDH1 for endocytosis and degradation (By similarity).  Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).  Its function in the WMM complex is unknown (PubMed:29507755).
What are the official names of this protein?
E3 ubiquitin-protein ligase Hakai, Casitas B-lineage lymphoma-transforming sequence-like protein 1, c-Cbl-like protein 1, RING finger protein 188, RING-type E3 ubiquitin transferase Hakai.
What is the protein family that this protein belongs to?
Belongs to the Hakai family.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
Protein: GRPE_FUSNP
Sequence: MKDKDIKEEVLKEEINKEVNEELKNEEVKEETHEHEHKHGGHTCCGKHGHKHNDEEIGKLKAEIEEWKNEYLRKQADFQNFTKRKEKEVDELKKFASEKIITQFLGSLDNLERAIESSIESKDFDSLLKGIEMIVRNLKDIMSAEGVEEIKTEGVYDPVYHHAVGVEANEDFKEDEIVKVLQKGYMMKGKVIRPAMVIVCKK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INH13_ECOLI
Sequence: MSHQLTFADSEFSSKRRQTRKEIFLSRMEQILPWQNMVEVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTTIMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPEMHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAEVDVDWLIAERPGKVRTLKQHPRKNKTAINIEYMKASIRARVEHPFRIIKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRADQMIRQWERSH
What is the function of this protein?
Involved in the transposition of the insertion sequence IS5.
What are the official names of this protein?
Transposase InsH for insertion sequence element IS5-13.
What is the protein family that this protein belongs to?
Belongs to the transposase 11 family.
Protein: MATK_KUNPU
Sequence: MEEFQGYLELDRSRQHYLLYPLLFREYIYALAHDHGLNRSILFESAGYDNKSSSIIVKRLITRMYQQNPLIFSAKDSIQNQFFGHNKNLYSQILSEGFAVIVEIPFSLRFLFLLERKEIAKSYHLRSIHSIFSFLEDKFTHLDYVSDVLIPYHIHLEILVQTLRYWVKDASSLHLLRLFLHDYWNSFITPKKHITFFFKGNPRLFLFLYNSHICEYEYIFLFLRNQSSHLRSTSSGIFFERIHFYVKIEHFVKVFFDNNFQCILWFLKDPFMHYVRYQGKFFMASKDTPLLMNKWKCYLVNLWQYHFSVWFQPGRIDINRLCKYSLDFLGYRSSVRLNSSVVRSQMLENLFLINNAMKKFETIVPIIPLIGSLYKSNFCNTFGHPISKPTRTHSSDSDIIDRFLRICRNLSHYHSGSSKKKSLYRVKYILRLSCVKTLARKHKRTVRTFVKRLGSEFLEEFLTEEEVFLSLIFPRTYSTSRRLYRGQIWYLDITSINDLVNYE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL20_ACIBC
Sequence: MARVKRGVVAHRRHKKILARAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQKKRQFRALWIARINAGARQNGLSYSRMIDGLKKAQVIIDRRVLADIAMHDAVAFAALAEKAKGALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: GSA_ALKOO
Sequence: MKKSQELMTRAKRVIPGGVNSPVRAFNAVGGCPRFIKSASGAYIQDVEGNSYIDYIGSWGPMILGHSNPKILQAVSKVMIKGLSFGAATELEVEMAELITRLVPSVEMVRMVNSGTEAVMSALRLARGYTKREKVIKFAGCYHGHSDSMLVKAGSGALVNGVPDSAGVTIGVAKDTLVAEYNDIDSVNLLFEQNKNEIAAVILEPVAANMGVVLPKDGFLEKVRQLCSQNGALLIFDEVITGFRLAAGGAQEYFGVTADLVTYGKIIGGGMPVGAYGGRREIMECISPIGPVYQAGTLSGNPLAMAAGITMLTELSENPQIYEHINRLGTKLGDGLRKITSNTVNSVGSLISMFMTENEVIDIRSAMASDTGEYSRLFNHLLNKGIYIAPAQFEAMFISNAHTDEDIEKTLSAIEESLNEMRKK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXB_AERS4
Sequence: MKIVVDENMPHALELFAEFGEVIPLPGRQMQAVDLQDADVLLVRSVTRVDAELLATSPRLRFVGTATIGTDHVDKALLAVRNIPFFSAPGCNKYSVGDYVLSTLLVLAERHELNLREMSLAVIGAGNTGECVACKAEALGMRVLRCDPPRARVAGQAGETDAFVDYQTALGADIVSFHVPITREGPDATFHLLDEQVIAARPAGQILVNASRGEVWDNQALLARQQGLEPLRLVMDVWEGEPEPLRALVPHTEIATPHIAGYSLEGKARGTWMLYQALCQQLGRAARQDLQSLLPAPEVRALTPGQPVDQALIKQLVHLIYDVRRDDARFRNRIELPGSFDEQRKHYPERRELSSLHVNGPFASDTLARLGFTVQPG
What is the function of this protein?
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
What are the official names of this protein?
Erythronate-4-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_GEOSL
Sequence: MNIHRKPEWLRKKINPAAHGAMDELLGELRLHTVCREARCPNITECFRERQATFLILGAECTRLCSFCNVTKGEPLPPDPDEPARVAQAVVRLSLAHVVITSPTRDDLPDGGAGHYVATVATIGRVAPATVVELLIPDFLGSRAALADVVAAAPRIIGHNVETVPRLYAIRAGADYGRSLAVLRTLRELAPGCATKSGLMLGLGETEEEVLAVMADLRRVDCTYLSLGQYLAPSRFHHPVREFVLPETFDRLKELAEKMGFRHVESGPYVRSSYHAAGYGGGTRTDQPVASGCLSDQEGVSAQ
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_METPP
Sequence: MSLNRNEKEAVVAQVSAQVAKAQTLALAEYRGLTVEHLNALRKQAREKGVYLHVLKNTLARRAVAGTSFEVAAGSMAGPLIYGFSEDAVAAAKVIADFAKGNDKLVIKAGAYAGKALDAEGVKALASIPSKEVLLSQLLGLMQSPVSRIARVLAALAEQRGGSAEAAPAEAAAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: Y465_CYTH3
Sequence: MEHIQKGIAGEQKACAFLEQQGYKIIEKNLRIGKGEIDLIAVHNNCMCFIEVKYRKHNRYGFPEEFVTQKKLLKIQETAEAYIYTVNWQGRIRFDVVAITGEELPVHLMDVTL
What are the official names of this protein?
UPF0102 protein CHU_0465.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: VJBR_BRUME
Sequence: MSLDLVHFPNYKKTFFGSSFQSDTLALLTRIRDEIGCRYVTHTYRGRVGDCTKVNSADLTVLMTLPATWVARYSSKNYFAIDPVFQEDAPYYRNDTSAIARDLKEDADICPAVAELLHDAEKHGLGNLFIAVSARNPKGVAGCTVFTFEVEDEDRTQFLARMRPRLLSLAGIIHGTVCGCKDANSVASLLTPREVDCLRWAANGKTDGEIAEILSIARWTVVTYLQNAKIKLNCSNRTSAVATALSLGIIDMPEVQHLV
What is the function of this protein?
Transcriptional regulator involved in the global control of Brucella gene expression.  Mediates the effects of the quorum sensing autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and diverse number of genes, including the virB operon and the flagellar genes fliF and flgE, which are activated in the absence of C12-HSL.  Regulates virulence factors as well as several membrane structures.  Implicated in the control of outer membrane composition.  Plays a role in the expression of genes involved in the EPS synthesis and/or export.  Mediates the inhibitory effect of C12-HSL on B. melitensis intracellular replication.  Could activate expression of ftcR.
What are the official names of this protein?
HTH-type quorum sensing-dependent transcriptional regulator VjbR.
Protein: ATPG_PROMM
Sequence: MANLKDIRDRIVSVKNTRKITEAMRLVAAAKVRRAQEQVLRSRPFADRLARVLENIQSRMSFEMADAPLLKTSDLKTITLLAVTGDRGLCGGYNSNIIKRTEQRYAELNGQGYKVDLVLIGRKAITYFSNRSSQYTIRATFTGLEQVPTSDDAESITTEVLAEFLSQSTDRIEVIYTKFINLVSCNPVVQTLLPLDPQGIAEADDEIFRLTTKDSRLTVEKGVGPANEQPPLPSDIIFEQSPEQLLNALLPLYLQNQMLRALQESAASELASRMTAMNNASDNAKALAKTLTLDYNKARQAAITQEILEVVGGSCT
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: CLPP_STAES
Sequence: MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQQDTDRDNFLTAAEAKEYGLIDEVMEPEK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS19_COREF
Sequence: MPRSLKKGPFVDEHLLNKVDAQNEKGTKQVIKTWSRRSTILPDFIGHTFAVHDGRKHVPVFVDDAMVGHKLGEFAPTKTFKGHVKDDKKGRR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: GET4_TAEGU
Sequence: MAAAIMAAEQEAAKGGGGRNRGGVQRVEGKLRASVEKGDYYEAHQMYRTLFFRYMSQGKHAEARELMYSGALLFFSHNQQNSAADLSMLVLESLEKSDAKVAEDLLENLAKLFSLMDPNSPERVAFVSRALKWSSGGSGKLGHPKLHQLLAITLWKEQNYSESRYHFLHSTDGEGCANMLVEYSSSRGYRSEVDMFVAQAVLQFLCLKNKTSASVVFTTYTQKHPSIEKGPPFVQPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLKRDPMYNEYLDRIGQLFFGVPPKQTSSYGGLLGNLLNSLMGTGEDDDTEEGQEDSSPIELD
What is the function of this protein?
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation.  The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane.  Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum.  Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome.  Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum.  The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome.  It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.
What are the official names of this protein?
Golgi to ER traffic protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the GET4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HIS4_BURCM
Sequence: MLLIPAIDLKDGQCVRLKQGDMDQATIFSEDPAAMARKWVDLGARRLHLVDLNGAFAGKPKNLDAIEAILDEVGDEIPVQLGGGIRSLETVEKYLDAGLSYVIIGTAAVKDPGFLRDACTAFAGNIIVGLDAKDGKVATDGWSKLTGHEVIDLALKFEDYGVESIVYTDIGRDGMLQGINIEATVKLAQAVGIPVIASGGLSNLADIDSLCEVEEHGVEGVICGRAIYSGDLDFAAAQKRADELNGELDNA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMJ_SHEAM
Sequence: MFPIQIAPNDPRLTQICARWDLTPNDNAEFSLLFEEDILTLKKRDEPKLGGIMVDFVSGAVAHRRKFGGGRGQAIAKAVGLKAGATPTVVDGTAGLGRDAFVLASLGCRVLLIERHPVVAALLEDGLRRAYLDGEIGPWMQQRMQLVHGSSLEALDNLEDKPDVVYLDPMYPHREKSALVKKEMRVFQSLVGADTDADGLLAPALRLAQKRVVVKRPDYAEDLDGVRPSTRIETKKNRFDVYVKAAMG
What is the function of this protein?
Specifically methylates the guanosine in position 1516 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase J, 16S rRNA m2G1516 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLGB_BACC1
Sequence: MNVINCEEVKRDEFHTEKYYESYNIFGAHIVTEDEMRGVRFTVWAPHAKAMSVVGDFNEWDYEQHKMLQVTEEGIWSLFIPHIEEKEIYKYAIETMAGDVIFKADPYAVYAEVRPNTASVVFDIKGYEWNDKNWSRKKKKKSVYKEAMTVYELHFGSWKKKEDGTLYSYREMAEELIPYVVEHQFTHIEIMPLVEHPYDRSWGYQGTGYYAATSRFGTPHDLMHFVDECHKYGIGVILDWVPGHFCKDAHGLYLFDGTPTYEYKDKDVQENPVWGTVNFDLGKREVRNFLISNALFWMRYFHIDGFRVDAVANMLYWNKEGQEQSNEHAVSFLRELNEAVFAEDEDFLMTAEDSTAWPLVTAPTYEGGLGFNYKWNMGWMNDVLKYMECAPEYRKYIHEKMTFSLLYAYSENFILPLSHDEVVHGKKSLLNKMPGDYWDKFAQLRLLYGYFFTHPGKKLLFMGGEFGQFDEWKDLEDLDWNLHDFEMHRYMHDYFKELIALYKRSKPLWQLDHSPEGFQWIDANNNEQSIFSFIRQGDKQEDALVVVCNFTKATYENYKVGVPDFEYYNEVLNSDAEQYGGSGQVNKKRLKAIQEPFHNQAAHVEITIPPFGVSILRPVKTRKGSKKQDGSKTKVRSNVTSRGKR
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: PUR7_YERPE
Sequence: MQKLAELYRGKAKTVYTTENPDLLVLEFRNDTSALDGQRIEQFDRKGMVNNKFNHFIMTKLEEAGIPTQMERLLSDTEVLVKKLEMIPVECVIRNRAAGSLVKRLGIEEGLSLNPPLFDLFLKNDAMHDPMVNESYCKTFGWATEAQLARMKELSYLANDVLSKLFDDAGLILVDFKLEFGLFNGEVVLGDEFSPDGSRLWDKKTLNKMDKDRYRQSLGGLIEAYEEVAHRIGVKLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: SYV_UREPA
Sequence: MKKKLSKKYSFKEVEANKLLFWQENNLFKAQINSTKKPFTIVLPPPNVTGHLHIGHAYDFTLSDILMRYKKLKGYDSFIIPGTDHAGIATQTKFEKNLKVNAQTNRFNLGRELFLEKLKIWKDEQINYIHKQWNALGLGLDYSNYLFTLDPIVVQTVREVFVKMFNEHIIYRDKKLVNWDIQLKTAISNIEVIHKEVEQKLYYIKYLSQDQKDFVVVATSRPETMFGDKYLVINPKDKRYFHLHNKIFINPINNIEMTVILDDYIDIEFGTGVMKCTPAHDFNDYELAKKHNLEIINIMNADGTLNEKCGEFKGLDRLEARSLIIDKLQKNNHLLKVESYRTSVGFSERTNEIVEPYLSHQWFIKMDSLIKDTIKMQDDCNNKVDFYPNRFNKTLLTWLKNTEDWCISRQLWWGHQIPVWYHKKTNQIYCDTIPPKDLENWIQDEDVLDTWFSSGMWPLLTTKWNYNSHFFDRYFPTSLIVTGMDILFFWVSRMMNFSQYLVEKKPFKDVLIHGLIRDSQGRKMSKSLGNGIDPFDIIDKYGLDAMRLFFASCTTIGEDLNFSTERLGANWNYLNKIWNIAKYIENLDEINDNLNFEDVDKFCDVNKWILTELSKLTLEINKNMDKYNLVVATKYLYDFIWNTFASYYLEYTKVLLQDLTLKNETIKTIRYVFNKILIMLQPFAPNISEEIWLCLNQTNNSILLQEYPIINFEFETIIIDKIAKIILEIRKLRLEENINNRINLCFELISPNDAFYKSKIKLVNLLLILVNAEINEIKKTSSNNYTYELVIDDFILKTSYEKPIDYVFQMKKASEQLNYLENEIQRATNLLNNSGFINKAPAQLIIKEKNKLINLKKEHANLLKTLTDLKQKVK
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM2_HORSE
Sequence: MCNTNMSVSTDGAVSTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVIFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVSQQEPSDSGTSVSENRCHLEGGSNQKDLVQELQEEKPSSSDMVSRPSTSSRRRAVSETEENSDELPGERQRKRHKSDNISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYRVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPPHCNRCWALRENWLPEDKGKDKGNMSEKAKLGDSMQEDEGFDVPDCKKSTVSDSRESCVEENDDKITQASLSQESEDYSQPSTSNSIIYSSQEDVKEFEREETQDKEESMESSFPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome.  Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.  Also acts as a ubiquitin ligase E3 toward itself and ARRB1.  Permits the nuclear export of p53/TP53.  Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.  Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation.  Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53.  Also a component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.  Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus.  Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.  Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells.  Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity).  Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (By similarity).  Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase Mdm2, Double minute 2 protein, Edm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2.
What is the protein family that this protein belongs to?
Belongs to the MDM2/MDM4 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus (By similarity).
Protein: ACTC_BRABE
Sequence: MEDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESTGVHETTYNSIMKCDIDIRKDLYANTVLSGGTTMFPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, cytoplasmic, BbCA1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.