PharMolix/UniProtQA huggingface dataset:
Protein: POLK_SCHPO
Sequence: MENAKDFIGETIKENGLLTIEDDGSSSSDEEATLKRRLAGPSVLKSGQENVNQKKINEIIYEASKGSKFFEAEQKRDRELRLRIEKVQVEVEKYQSKLRFDKAFQREWTIRQESVDTTVEDFRAKRDLTQIIVHVDCDAFYASIEELKNPKLKSLPMAVGKSVLCTANYVARKFGVRSAMPEFIARKICPDLVVIPLNLSEYAIKSKEIQNVLAQYDSNLCPASIDEFYMNLTSHLRLQELAFTVENITMVVEKIRKQVHEETGVTVSCGIAANKLLAKIASNKRKPNNQFFIPFDEIGISKFMNDLPVREVSGIGRVLEQQLLGLEIKTCGDIQRNLVILSYIFLPKSFQNLLRCSYGFGTTILDEYGESKRKTIGSEATFSSNLSSPSIIEYKLRLLVQNVSENLQKRGLVTNSIAIKYKTSEFQVHTKQKSIGQFIHSESDLLKPALQLLRQSYPMTIRLLGVRATKLVSKSRCLAMQLKFQSQNTVPCPVCQKNIENELGILNQHVDLCLNVETVKSLINTDHTANPTIKKRKSNTLDTYFLE
What is the function of this protein?
DNA polymerase specifically involved in DNA repair.  Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls.  Has a role in meiosis.
What are the official names of this protein?
DNA polymerase kappa, Meiotically up-regulated gene 40 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Associates with chromatin.
Protein: FPG_METNO
Sequence: MPELPEVETVRRGLEPALVGACFSHVHLARPDLRFPLPERFAARLTGQRVEALSRRAKYLVADLSSGEALIMHLGMSGRFDVVLPDGRQVSPGDFYLEGAGARAKHDHVSFALSNGARVTYNDVRRFGFMDLVPAAELATCRHFAGMGIEPLGNELSGEAVARLFRGRRTPLKAALLDQRLIAGLGNIYVCEALHRARLHPETPAGALADAAGRPTKAARLLAEVIRDVLTEAVAAGGSTLRDYVHTDGTKGAFQHAFRVYDREGLACTARGCRGVVRRVVQSGRSTFFCEVCQPAR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: RL36_PROMH
Sequence: MKVRASVKKMCRNCKIVRRHGHVRVICSVDPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: RL13_SYNR3
Sequence: MNKTVVPSLNTVERHWYVVDAENQCLGRLATEVASVLRGKNKPTYTPHLDTGDFVVVINADKVKVTGNKASDKLYRRHSGRPGGMKVETFAALQQRIPERIVEKAIKGMLPHNALGRQLFRKLKVYKGAEHPHGAQQPQPYQLNPSASIK
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: AUXCP_BPCA1
Sequence: MVISINQVRQLYVAKALKANTAALTTAGDIVPKADTAKTTLYFQSMSPAGIVASDKINLKHVLYAKATPSEALAHKLVRYSVTLDADVSATPVAGQNYILRLAFRQYIGLSEEDQYFKYGEVIARSGMTASDFYKKMAISLAKNLENKTESTPLVNIYLISAAAASTDVPVTSATKESDLTATDYNQIIIEETEQPWVLGMMPQAFIPFTPQFLTITVDGEDRLWGVATVVTPTKTVPDGHLIADLEYFCMGARGDIYRGMGYPNIIKTTYLVDPGAVYDVLDIHYFYTGSNESVQKSEKTITLVAVDDGSHTAMNALIGAINTASGLTIATL
What is the function of this protein?
Auxilliary capsid protein that forms an outer layer on the major capsid protein protrusions.
What are the official names of this protein?
Auxiliary capsid protein, Gene product 36, gp36.
Protein: LINES_HUMAN
Sequence: MKVFCEVLEELYKKVLLGATLENDSHDYIFYLNPAVSDQDCSTATSLEWANTCGIQGRHQPISVGVAPIAVAPVCLKTNSQMSGSREVMLLQLTVIKVMTTRILSVKTEFHAKEQYRDVIKILLESAKVDSKLICMFQNSDKLLSHMAAQCLALLLYFQLREKITLSNSWIAFCQKNLSEYSESNKAIYCLWTLTAIIKEIFKDSCSQKTEILKQFLTHFDTIFEVFYNSLFSQHFENCRDTSKIVNILMCFLDLLELLIASRIHLKLHFTCQRILFLKPSCMLEVITWPIQAFVKRKVIIFLKKCLLCKVGEDLCRGSVPALMPPDHHVAVDMLALANAVLQAVNSGLLKTLSVYEKHSFFGGDEVQPECELITSPDHVILRAASLVIMKSLEIKFQNYSSASEVKVDLQRFMSELLTFLKPHLQPSLQLHNPCKWLSRVFIEQDDDMLEAAKASLGIYLTLTRGCEATESLTQGKEMWDHHTHENGYNPHCIFLFFLKNIGFDSTVLLDFLISSETCFLEYFVRYLKLLQKDWDNFFTICNNFDATESKYDISICGCVPSLVQDQSSNQTIPHRLTAPHSHRDVCARHSWASDAPSEPLKAVMSKGAHTMCASSLSSPRASQSLVDYDSSDDSDVESTEQCLANSKQTSLHQQATKEIQDAAGTSRDKKEFSLEPPSRPLVLKEFDTAFSFDCEVAPNDVVSEVGIFYRIVKCFQELQDAICRLQKKNLFPYNPTALLKLLKYIEVISNKTMNTL
What are the official names of this protein?
Protein Lines homolog 1, Wnt-signaling molecule Lines homolog 1.
What is the protein family that this protein belongs to?
Belongs to the protein lines family.
Protein: Y587_PSEAE
Sequence: MSYVIDRRLNGKNKSTVNRQRFLRRYREHIKKAVEEAVSRRSITDMEHGEQISIPGRDIDEPVLHHGRGGRQTVVHPGNKEFTAGEHIARPSGGGGGRGGGKASNSGEGMDDFVFQITQEEFLDFMFEDLELPNLVKRHITGTDTFKTVRAGISNDGNPSRINIVRTLRSAHARRIALSGGSRAKLRAALKELERIKREEPDNLGDIQELELEIAKLRARIDRVPFLDTFDLKYNLLVKQPNPTSKAVMFCLMDVSGSMTQATKDIAKRFFILLYLFLKRNYEKIEVVFIRHHTSAREVDEEEFFYSRETGGTIVSSALKMMQEIMAERYPTHEWNIYAAQASDGDNWNDDSPVCRDILLKQIMPFVQYYTYVEITPREHQALWFEYERVREAFEDSFAQQQIVSASDIYPVFRELFQRRLVA
What are the official names of this protein?
UPF0229 protein PA0587.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: HISX_SHISS
Sequence: MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDDALREYSAKFDKTTVNALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPARIAGCKKVVLCSPPPIADEILYAAQLCGVKDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPDADMAHQVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARDLVDGITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: TRUB_BORBR
Sequence: MAKRRGLALDGVLLLDKPVGLSSNHALQRAKRTVDAAKAGHTGTLDPFATGLLVCCMGRATKISGRMLEADKTYQATLQFGEETDSGDLTGHIVARAPDGFAGVEEAALRDVLSRFVGTIEQIPPMYSALKRDGKPLYEYARAGIELDRPPRQVTIRHIELLSFSGMQAQIDVACSKGTYIRTLAQDIGRALGCHAHLAALRRTHVGPFSLDRAVTLEALQAMPDAKQALLAMNELPAGLLPAT
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: ATPG_ACET2
Sequence: MAHINEIKLRMKSIRETRQITNAMKLISAAKLKKAKKQLEKASPYFEKVRSTMADILLRSGKIENKYFHARDEKTDKKKAYIVITGEKGFAGGYNHNIIKFTEECLKQDKDPLLFVAGNVGRNHFLKNKYNVYMEFDYPVQNPSIYMAREIMEVILDLFDKEVFDELYIIYTHMFSNIKMEPSIIKLLPLELDTLKEKLQINESTEKIVDGCMEYEPDPEYVFNVLVRKYIKGVVYGAFVESFTSEQNSRMTAMDNATANANDMLKKLDLLYNRARQSKITQDITEIVGGAEALK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HISX_CHLTE
Sequence: MLTIYHFPQDEAALREQLNRTVSFDPDAQRTVDDILYRVRTEGDAAVLDYTERFQGIRLYDMRVPEAEIEAAYAAADPEFIAILEEAFANITAFHRNEAEKSFFYEQKGGVILGQRVTPMEKALLYVPGGKAAYPSSVLMNAAPAQVAGVDEISMTTPCDAEGKVNPHILAAAKVAGITSVYRLGGAQAVAAFAYGTATIPKVDIVTGPGNKYVALAKKQVFGHVAIDSIAGPSEVVVIADAGAEPEFIVMDMFAQAEHDPDASAVLITPSAELADAVRETAARLAGTMLRGEVITRALTDNGAIVVTGSMQEACKVSDMIAPEHLELHVDNPWEILPDLRHAGAIFMGQWSCETVGDYFAGPNHTLPTNGTARFFSPLSVRDFVKHTSIIAWSKSELARTGEKIARFADHEGLQAHAEAVRVRLKHL
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: IF5A_AERPE
Sequence: MSVNYATLGDLKKGSYIVIDGEPCRIVEMSRAKTGKHGSAKAHVVAICVFSGQKKSLVAPVDTRVQIPVIEKRLGQVLADMGDMVQIMDLETYDTFEVEKPGGNEEEEQLAAKLQPGVTVEYWLIMGKPKIIRIRSSSS
What is the function of this protein?
Functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Translation initiation factor 5A, Hypusine-containing protein, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAK_VIBCM
Sequence: MGKIIGIDLGTTNSCVAVLDGDKPRVIENAEGERTTPSVIAYTDGETLVGQPAKRQAVTNPQNTLFAIKRLIGRRFEDEEVQRDIKIMPYKIVKADNGDAWVEAKGQKMAAPQVSAEVLKKMKKTAEDFLGEPVTAAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKQGGDRTIAVYDLGGGTFDISIIEIDEVEGEKTFEVLSTNGDTHLGGEDFDNRMINYLVDEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLEALVEDLVQRSLEPLKVALADADLSVNDITDVILVGGQTRMPMVQKKVAEFFGKEPRKDVNPDEAVAVGAAVQGGVLAGEVKDVLLLDVTPLSLGIETMGGVMTKLIEKNTTIPTKANQVFSTAEDNQSAVTIHVLQGERKQAMYNKSLGQFNLEGINPAPRGMPQIEVIFDLDADGILHVSAKDKQTGKEQKITIQASGGLSDAEIEKMVQEAEANKEADKKFEELATARNQADQMIHATRKQITEAGEALPADEKAKIETAINELETAKKGEDKAEIDAKVQALMAAAQKLMEIAQQQAQAQGANAGQSSAKEDDVVDAEFEEVNDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL2_STRPG
Sequence: MGIKVYKPTTNGRRNMTSLDFAEITTSTPEKSLLVSLKSKAGRNNNGRITVRHQGGGHKRHYRLIDFKRNKDGVEAVVKTIEYDPNRTANIALVHYTDGVKAYIIAPKGLEVGQRIVSGPDADIKVGNALPLANIPVGTVVHNIELKPGKGGELVRAAGASAQVLGQEGKYVLVRLQSGEVRMILGTCRATIGTVGNEQQSLVNIGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGKAPVGRKAPSTPWGKPALGLKTRNKKAKSDKLIVRRRNEK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RS18_ARGIR
Sequence: MALIIPEKFQHILRVMNTNIDGKRKIMFAMTAIKGMGRRYANVVCKKADVDITKRAGELSEDEIERVITIMSNPRQYKIPNWFLNRQKDVKDGKYSQVMSNALDNKLREDLERLKKIRAHRGLRHYWGLRVRGQHTKTTGRRGRTVGVAKKK
What is the function of this protein?
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
What are the official names of this protein?
40S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCB22_ORYSI
Sequence: MENMRSENFNQGVSMEGVKHAPEMANTNRRALRDIKNIIGAPHQHMAVSKRGLLDKPAAKNQAGHRPMTRKFAATLANQPSSAPLAPIGSERQKRTADSAFHGPADMECTKITSDDLPLPMMSEMDEVMGSELKEIEMEDIEEAAPDIDSCDANNSLAVVEYVDEIYSFYRRSEGLSCVSPNYMLSQNDINEKMRGILIDWLIEVHYKLELLDETLFLTVNIIDRFLARENVVRKKLQLVGVTAMLLACKYEEVSVPVVEDLILICDRAYTRTDILEMERMIVNTLQFDMSVPTPYCFMRRFLKAAQSDKKLELMSFFIIELSLVEYEMLKFQPSMLAAAAIYTAQCTINGFKSWNKCCELHTKYSEEQLMECSKMMVELHQKAGHGKLTGVHRKYSTFRYGCAAKSEPAVFLLKSVAL
What is the function of this protein?
Involved in the control of the cell cycle at the G2/M (mitosis) transition.  May associate to CDKB2-1 and activate CDKB2-1 kinase to promote cell division.
What are the official names of this protein?
Cyclin-B2-2, CycOs2, G2/mitotic-specific cyclin-B2-2, CycB2;2.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin AB subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Expressed during interphase, prophase, metaphase and disappears at anaphase and telophase.
Protein: YBEY_BRUME
Sequence: MSDNAIHIDIMIEAGNWPDEASLESLVSKSVAAAWNNLGLKSATSELSVVFTDDASIQLLNGEWRGKDKPTNVLSFPAFPVKAGSQPGPMLGDIVIARETVEREAKEEGKPIENHLSHLVVHGFLHLLGYDHETDEEAEVMEAREREILHALAIPDPYAVSDEDINND
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_PARD8
Sequence: MIEYIKGEIVELTPTRMILECGGIGYELNISLNTYSAFGNKTTGKIYIYEVIREDAHLLFGFAEKIERELFLLLTSVSGVGPNTARMILSSLPPSELVQVIGSKNEAALTAVKGIGLKTAQRILVDLKNKVKPMESMAGNLPEASVSNGAVTEEAVAALVMLGFQKAASQKAVSAILKGSPTLAVEQVIKTALRML
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ARGB_BURO1
Sequence: MSEPIDLSQIAPTLKAEILAEALPYIRRYHGKTVVIKYGGNAMTEERLKQGFARDVILLKLVGINPVIVHGGGPQIDHALKKIGKAGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVMLINHFGGHAVGLTGKDGGLIHARKLLMPDRDNPGQYIDIGQVGEVEAINPAVVKALQDDAFIPVISPIGFGEDGLSYNINADLVAGKLATVLNAEKLLMMTNIPGVMDKDGNLLTDLSAREIDALFEDGTISGGMLPKISSALDAAKSGVKSVHIVDGRIEHSVLLEILTEQPFGTMIRSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
Protein: RUVB_ERWT9
Sequence: MIEADRLVSAGVISEEEVIDRAIRPKMLAEYVGQPVVREQMEIFIKAAMMRGDALDHLLIFGPPGLGKTTLANIVANEMGVNLRTTSGPVLEKAGDLAALLTNLEPHDVLFIDEIHRLSPVVEEVLYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYRVEDLQHIVGRSAACLGLPLSDEGALEIARRARGTPRIANRLLRRVRDFAEVRAGGEMSGDVASRALDMLSVDSEGFDYMDRKLLLAIIDKFTGGPVGLDNLAAAIGEERETIEDVLEPYLIQQGFIQRTPRGRMATQHAYKHFGITREG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ZSS1_ZINZE
Sequence: MERQSMALVGDKEEIIRKSFEYHPTVWGDYFIRNYSCLPLEKECMIKRVEELKDRVRNLFEETHDVLQIMILVDSIQLLGLDYHFEKEITAALRLIYEADVENYGLYEVSLRFRLLRQHGYNLSPDVFNKFKDDKGRFLPTLNGDAKGLLNLYNAAYLGTHEETILDEAISFTKCQLESLLGELEQPLAIEVSLFLETPLYRRTRRLLVRKYIPIYQEKVMRNDTILELAKLDFNLLQSLHQEEVKKITIWWNDLALTKSLKFARDRVVECYYWIVAVYFEPQYSRARVITSKAISLMSIMDDIYDNYSTLEESRLLTEAIERWEPQAVDCVPEYLKDFYLKLLKTYKDFEDELEPNEKYRIPYLQEEIKVLSRAYFQEAKWGVERYVPALEEHLLVSLITAGYFAVACASYVGLGEDATKETFEWVASSPKILKSCSIHCRLMDDITSHQREQERDHFASTVESYMKEHGTSAKVACEKLQVMVEQKWKDLNEECLRPTQVARPLIEIILNLSRAMEDIYKHKDTYTNSNTRMKDNVSLIFVESFLI
What is the function of this protein?
Catalyzes the formation of alpha-humulene in the first step of zerumbone biosynthesis, a highly promising multi-anticancer agent.  Also mediates formation of beta-caryophyllene at a much lower level.
What are the official names of this protein?
Alpha-humulene synthase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: TRUA_ECO27
Sequence: MSDQQQPPVYKIALGIEYDGSRYYGWQRQNEVRSVQEKLEKALSQVANEPITVFCAGRTDAGVHGTGQVVHFETTAQRKDAAWTLGVNANLPGDIAVRWVKAVPDDFHARFSATARRYRYIIYNHRLRPAVLSKGVTHFYEPLDAERMHRAAQCLLGENDFTSFRAVQCQSRTPWRNVMHINVTRHGPYVVVDIKANAFVHHMVRNIVGSLMEVGAHNQPESWIAELLAAKDRTLAAATAKAEGLYLVAVDYPDRYDLPKPPMGPLFLAD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: T2R16_PONPY
Sequence: MIPIQLTVFFMIIYVLESLTIIVQSSLIVAVLGREWLQVRRLMPVDMILISLGISRFCLQWASMLNNFCSYLNLNYVLCNLTITWEFFNILTFWLNSLLTVFYCIKVSSFTHHIFLWVRWRILRWFPWILLGSLTIACVTIIPSAIGNYIQIQLLTMEHLPRNSTVTDRLEKFHQYQFQSHTVALVIPFILFLASTILLMASLTKQIQHHSTGHCNPSMKAHFTALRSLAILFIVFTSYFLIILITIIGTLFDKRCWLWVWEAFVYAFILMHSTSLMLSSPTLKRILKGKC
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May function as a bitter taste receptor for the phytonutrient beta glucopyranosides, some of which are toxic and some of which lower the risk of cancer and cardiovascular disease.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 16, T2R16.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HUPT_AZOCH
Sequence: MHSREAIEAYYRAVGTRMAGLPVYNPALAVELLGWRAVEGVGALGVLITPWCMNLFWQPPAEAELPTKGERAVLSLPSGDYECTLHEDESLGRYASASLCSPMQDFPDQAGARAMAEEVLRLVFAESEPPQPAQLTRRALFRRALGGAS
What are the official names of this protein?
Hydrogenase expression/formation protein HupT.
What is the protein family that this protein belongs to?
Belongs to the HupJ family.
Protein: AAS_YERPY
Sequence: MAYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTSITDTWYMRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKKTLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTIVTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADDSALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFARVRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLINVPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFTTDSEITRERLIKAARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
What is the function of this protein?
Plays a role in lysophospholipid acylation.  Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium.  Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
What are the official names of this protein?
Bifunctional protein Aas.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SET4_YEAST
Sequence: MTSPESLSSRHIRQGRTYTTTDKVISRSSSYSSNSSMSKDYGDHTPLSVSSAASETLPSPQYMPIRTFNTMPTAGPTPLHLFQNDRGIFNHHSSSGSSKTASTNKRGIAAAVALATAATIPFPLKKQNQDDNSKVSVTHNESSKENKITPSMRAEDNKPKNGCICGSSDSKDELFIQCNKCKTWQHKLCYAFKKSDPIKRDFVCKRCDSDTKVQVNQVKPMIFPRKMGDERLFQFSSIVTTSASNTNQHQQSVNNIEEQPKKRQLHYTAPTTENSNSIRKKLRQEKLVVSSHFLKPLLNEVSSSNDTEFKAITISEYKDKYVKMFIDNHYDDDWVVCSNWESSRSADIEVRKSSNERDFGVFAADSCVKGELIQEYLGKIDFQKNYQTDPNNDYRLMGTTKPKVLFHPHWPLYIDSRETGGLTRYIRRSCEPNVELVTVRPLDEKPRGDNDCRVKFVLRAIRDIRKGEEISVEWQWDLRNPIWEIINASKDLDSLPDPDKFWLMGSIKTILTNCDCACGYLGHNCPITKIKNFSEEFMRNTKESLSNKSYFNTIMHNCKP
What is the function of this protein?
Putative chromatin regulator.
What are the official names of this protein?
SET domain-containing protein 4.
What is the protein family that this protein belongs to?
Belongs to the SET3 family.
Protein: KDSA_BORPA
Sequence: MMKACGFDIGLDHPFFLIAGPCVIESRELAFETAGRLKEITGKLGVPFIYKSSFDKANRSSGKSFRGPGMDEGLKILADVRAQLDVPVLTDVHDIDQVAPVAAVVDMLQTPAFLCRQTDFIRACAATLKPVNIKKGQFLAPHDMLQVARKARDAALEAGGDGNNILVCERGASFGYNNLVSDMRSLAIMRETDCPVVFDATHSVQLPGGQGASSGGQREFVPVLARAAVAVGVAGLFMETHPNPACAMSDGPNAVPLDRMAELLESLVALDRVTKRSGFLENQFV
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TOP1_MONPV
Sequence: MRALFYKDGKLFTDNNFLNPVSDDNPAYEVLQHVKIPTHLTDVVVYEQTWEEALTRLIFVGSDSKGRRQYFYGKMHIQNRNAKRDRIFVRVYNVMKRINCFINKNIKKSSTDSNYQLAVFMLMETMFFIRFGKMKYLKENETVGLLTLKNKHIEISPDEIVIKFVGKDKVSHEFVVHKSNRLYKPLLKLTDDSSPEEFLFNKLSERKVYECIKQFGIRIKDLRTYGVNYTFLYNFWTNVKSVSPLPSPKKLIALTIKQTAEVVGHTPSISKRAYMATTILEMVKDKNFLDVVSKTTFDEFLSIVVDHVKSSTDG
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils.  Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase I, DNA topoisomerase 1.
What is the protein family that this protein belongs to?
Belongs to the type IB topoisomerase family.