PharMolix/UniProtQA huggingface dataset:
Protein: CYFP2_HUMAN
Sequence: MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQACQWSPRALFHPTGGTQGRRGCRSLLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
What is the function of this protein?
Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis.  Does not bind RNA.  As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
What are the official names of this protein?
Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121.
What is the protein family that this protein belongs to?
Belongs to the CYFIP family.
Protein: ADA2_CHICK
Sequence: TPLWSLMQDLMM
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.  Plays an important role in purine metabolism and in adenosine homeostasis.  Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity).
What are the official names of this protein?
Adenosine deaminase 2.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Protein: ACKA_STRGC
Sequence: MSKTIAINAGSSSLKWQLYLMPEEKVLAKGLIERIGLKDSISTVKFDGRTEKQVLDITDHTQAVKILLDDLMRFNIIASFDEITGVGHRVVAGGEYFKDSALVDEEVIQKVEELSLLAPLHNPANAAGIRAFKELLPDITSVVVFDTSFHTTMPEKAYRYPLPTKYYKENKVRKYGAHGTSHEYVAHEAAKLLGKPLEELKLITCHIGNGASITAVDKGVSVDTSMGFTPLGGVMMGTRTGDIDPAIIPYLMQHTDDFKTPEDISRILNRESGLLGVSEKSSDMRDIHEAMRAGDAKAQLANDIFVDRIQKYIGQYLAVLNGADAIIFTAGIGENSVTIRKLVIEGISWFGCDIDPEKNVYGQYGNISTPEAKVRVLVIPTDEELVIARDVERFKK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_XANCB
Sequence: MNQMVDMGHAVPAARGLREARAFAPASVANVAVGFDLLGYPLDGVGDTVTVRRIDAPVVRIAAIRGTTVALPLEAERNTAGAALMSLRAALALPFGFELEIDKGIALSSGMGGSAASCVAALVAANALLDTPVSTDQLYQHALDGEAVASGSRHGDNLGPLFLGGLVLCTLERLVPIAVPEAWHSLVVHPEAVLETRRAREALAGDYRLSEFVAQSTNLALVLAGCHAGDADLVRAGLRDVLVEPRRAPLITGFAQAKQAALAHAALGASISGAGPSVFAWFETRAAAAAAAPAVQAAFAGVGLDSQAWVTPINSPAARLLA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_ECOLI
Sequence: MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKFDGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLDPSEYANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQALLALVLNRDLVL
What are the official names of this protein?
Aspartate carbamoyltransferase catalytic subunit, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL5_PHOV8
Sequence: MSNTASLKKEYAERIAPALKNQFQYSSTMQIPVLKKIVINQGLGMAVADKKIIEVAINELTAITGQKAVATVSRKDIANFKLRKKMPIGVMVTLRRERMYEFLEKLVRVALPRIRDFKGIESKFDGRGNYTLGIQEQIIFPEINIDSITKILGMNITFVTSAPTDEEGYALLKEFGLPFKNSKKD
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: ZAPA_HAES1
Sequence: MSKLIELSVSGQVLRLNCPPEQHDALRQAAHLLDNRVMEMRERTGILQMEKILSIVALNLSFELMQEQQKTQTIENVINQKIAQLEGSLENILAQKTTF
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division (By similarity).
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid- cell.
Protein: SEMG2_MACMU
Sequence: MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLSSGSSRFPHRHRSQHYSGQKDKQHTESKGSFSIQHTYHVDANDHDRTRKSQQYYLNAQHKTTKSKQHLRRRQRLLNYKQKGRGRVKPKRHFHLIVIHRKGGQVHHGTQNPSQDQGNSPSGKGIFRQYSNTEERLWFRGLSKEQASASGAQKGRTQGGSQTNYVLQTEELVANKQQNKQQRETQNSHRNKGHYQNVFEVREEHSSKLQTSLHPAHQHRLQHGYKDIFTTQNELLVYNKNQHQTKNLNQDQEHGQKAHKGSYQSSSTEERQPNHEENSVQKGVPKGSISIQTEEKIYGKSQNQVTIPSQDQEHGHKENKISYQSSSAEERRLNSGEKGIQKGVPKGSISIQTEEKIYGKSQNQVTIPSQDQEHGHKENKISYQSSSAEERRLNSGEKGIQKGVPKGSISIQTEEKIYGKSQNQVTIPSQDQEHGHKENKISYQSSSTEERRLNSGEKGIQRGVSKGSISIQTEEKIHGKSQNQVAIPSQDQEHGHKENKISYQSSSAEERQLNSGEKGIQKGVSKGSISIQTEEKIYGKSQNQVTIPSQDQEHGHKENKIAYQSSSTEERQLNYGGKSIQKDVSQSSLSFQTEKLVEGKSQIQTPNPNQGQWSGQNAKGNSGKSADREQDLLSHEQEGRYQQEFSGAHNTVNIEHEVAYDDLLTQQYNEDRNPVST
What is the function of this protein?
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
What are the official names of this protein?
Semenogelin-2, Semenogelin II, SGII.
What is the protein family that this protein belongs to?
Belongs to the semenogelin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CRCB_PSET1
Sequence: MIALGGASGACLRFFISESMLKLLGRGFPFGTLAVNILGSLLMGILYGLLDKDIIAESPAKALIGVGFLGALTTFSTFSMDSLLLLQQGHFIKMALNIILNVMVCIFMAWLGLQLVMQKG
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS17_STRP8
Sequence: MERNQRKTLYGRVVSDKMDKTITVVVETKRNHPVYGKRINYSKKYKAHDENNVAKEGDIVRIMETRPLSATKRFRLVEVVEKAVII
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PURQ_CHLL3
Sequence: MADITIGVVVFPGSNCDHDTMHAVASFEGVKPVMLWHGSHDLQGAKAIILPGGFSYGDYLRAGSIARFSPIMQEVVDAAGKGLPVLGICNGFQVLLESGLLDGALSRNRDKKFLCRDTYIRPVNSNTMFTGLYREDEVLSIPIAHGEGNYFAPPEVIESLEEHDQVVFRYTDREGHVSDEANPNGSVGNIAGIMNRNGNVLGLMPHPERASEKLLGSEDGRRLFASLFRQL
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AAA1_MOUSE
Sequence: MRRDSDMASHIQQPGGHGNPGPAPSPSPGPGPGPGASERVALKKEIGLVSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPATASRVLSMACLMLLTWVNSSSVRWATRIQVIFTGGKLLALSLIITVGFVQIFQGHFEELRPTNAFAFWMTPSVGHLALAFLQGSFAFSGWNFLNYVTEELVDPRKNLPRAIFISIPLVTFVYTFTNVAYFTAMSPQELLSSNAVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTSSRLCFSGAREGHLPSFLAMIHVRRCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLVLRWRRPALHRPIKVNLLVPVVYLVFWAFLLVFSFISEPMVCGVGIIIILTGVPIFFLGVFWRSKPKCVHRFTESMTRWGQELCFVVYPQGSLEEEENGPMGQPSPLPITDKPLKTQ
What is the function of this protein?
Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane.  Preferentially mediates exchange transport, but can also operate via facilitated diffusion (PubMed:10734121) (By similarity).  Acts as a major transporter for glycine, L- and D-serine in the central nervous system.  At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (PubMed:25755256, PubMed:27759100).  At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity).  May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (PubMed:33707431).
What are the official names of this protein?
Asc-type amino acid transporter 1, Asc-1, D-serine transporter, Solute carrier family 7 member 10.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SLA_GLOHA
Sequence: YEGHCYQTFKLFKTWADAESFCTEQAKGGHLVSIESDGEADFVAQLVAENIQKTEIYVWVGLRVQGKEQQCSSEWSDGSSVSYQNWIEAESKTCLGLQKETEFRKWFNIYCGERNPFVCEA
What is the function of this protein?
Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factor IX (F9) (but not factor X) in the presence of calcium with a 1 to 1 stoichiometry.
What are the official names of this protein?
Snaclec coagulation factor IX-binding protein subunit A, IX-bp subunit A.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: SEPF_LISMC
Sequence: MGLSNKFKSFFFLDEEEEYYEEEVAREPEPMQKKTKKEKPNKNRFYAVEEDDAKVVSMQGAQFSSRMVLAEPRVYAEAQELADYLKEYKSVVVNLQRISHDQATRIVDFLSGTVYALGGDIQRVGNNIFLCTPDNVEVDGSISEMLDEQNFM
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: PCKA_BACAH
Sequence: MSTVNVQIGLHELLNGSNAQIQLSVPQLVEKVLMRNEGKLTSTGAVSASTGKYTGRSPKDKFIVKEASVADKIAWGAVNQPISEEHFNKLYTKVLEYLKEKEELFVFKGFAGADRNYRLPIQVINEYAWHNLFVHQLFIRPTEEELTTHESEFTIVSAPNFKADPAVDGTNSEAFIMVSFEKRIVLIGGTEYAGEMKKSIFSIMNFLLPEQDILSMHCSANVGEEGDVALFFGLSGTGKTTLSADPNRKLIGDDEHGWSDNGVFNIEGGCYAKCVNLSHEKEPQIFDAITFGSVLENVIINDQTRIADYNDTTLTENTRAAYPMHAIDNIVLPSVAGHPNTIIFLTADASGVLPPISKLSKEQAMYHFLSGYTSKLAGTERGVTSPQATFSTCFGSPFLPLDASRYAEMLGEKIEKHDAKVFLVNTGWTGGEYGVGKRMNLGYTRAMIQAALNGELAKTETAKHDIFGLEVPLHVPGVPDEVLMPEQTWADKAAYKAKAIELANEFKANFKKFDSVSEDIINLGGPIA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIEAP_DANRE
Sequence: MADTLRRLVNSSPYSVLQDKLDAWYKDYHVYSCDQNLNRCCELVELTSKIQGQLFTILNLTAQEGGHYSGVDTLKSRLLPWLGSCFTIAASAVSSDTSLSLIQESVEKDRKIRELSSVHESNLQKIEDQLCSTRIELDSVKRELVDTHIELDSTKNKSATTLLATEDEILHLKSELRVAQDQLDLYKRKLDVLDDYERQVRILRDEVSFLNAEKTVLQDRLARSRSPSPLLRRSRSVSPVRGESPTRAQLTSSSRHARLVSRFSDLYATERLESQSLLLKYIDDLETVQRILFIAAVESFQAAKLAYRQFKSRVRKTLSSTHIGPESLEDAVVDYIVRNLDLYDVQTSINDVINAMNVNPRISFPPEVDFVLISSFIREACRIAFAMQTLDPPLDLAFSSDGELYSDVKYRRSFDSEFTAPLVAFHVWPALLEGDTVILKGEAVTRRGALWKSRSRSSSPVRSRSGSPSRTFMASHSRSPSPGRLSSSRL
What is the function of this protein?
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage.  Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen.  Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (By similarity).
What are the official names of this protein?
Mitochondria-eating protein, Spermatogenesis-associated protein 18.
What is the protein family that this protein belongs to?
Belongs to the MIEAP family.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress.
Protein: ATP6_RHOPS
Sequence: MAADPIHQFQITKLFTLGHIGGQEIAFTNSSAYMFLSVGVISLLMIGGMAGRQLVPGRIQSVAELSYEFVAGIIRSTAGKEGMKFFPLVFSLFMFIAVSNLIGIIPYTFTVSSHLIVTVALALLVFVIVLFYGLYKNGLKFFKLFVPSGVPVYILPLVVFIEVISFFLKPVSHSVRLFANMLAGHIALKVFASFVGMLGALGFLGWMGAILPLGLTVAVTALEILVAFLQAYVFTILTCIYLNDAMHPGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTND1_CAEBR
Sequence: MAYFMANATRENCQDECRLSPNRDAVEEDLKKIGVECTKVDFDDANVQEDLDQLIKKYNMNYHDEIHICRETMPNFDEKLKIFFEEHLHDDAELRVIKHGAGYFDVRAKDEQWIRIPVRRGDFVFLPPGIYHRFTTDRSEDVVALRLFRNNPKWTAFNRSENGDKQPIREQYLKDVSA
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase 1, Acireductone dioxygenase (Fe(2+)-requiring) 1, ARD' 1, Fe-ARD 1, Acireductone dioxygenase (Ni(2+)-requiring) 1, ARD 1, Ni-ARD 1.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL14_PHOPR
Sequence: MIQMQSTLDAADNSGARRVMCIKVLGGSHRRYAHIGDIIKITVKEAIPRGKVKKGDVLKAVVVRTRKGVRRQDGSVIRFDRNACVLLNDTTEQPIGTRIFGPVTRELRNTKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: SEM1_MOUSE
Sequence: MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS
What is the function of this protein?
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.  Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.  Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3.  The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.  Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability.  R-loop accumulation increases in SEM1-depleted cells.
What are the official names of this protein?
26S proteasome complex subunit SEM1, 26S proteasome complex subunit DSS1, Deleted in split hand/split foot protein 1 homolog, Split hand/foot deleted protein 1 homolog, Split hand/foot malformation type 1 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the DSS1/SEM1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL33_PSYWF
Sequence: MRDKIKLVSTAGTGYFYTTTKNKRTMPGKMEIKKFDPKVRQHVIFKEAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: ATPAM_ORYSA
Sequence: MEFSPRAAELTTLLESRMTNFYTNFQVDEIGRVVSVGDGIARVYGLNEIQAGEMVEFASGVKGIALNLENENVGIVVFGSDTAIKEGDLVKRTGSIVDVPAGKAMLGRVVDALGVPIDGKGALSDHERRRVEVKAPGIIERKSVHEPMQTGLKAVDSLVPIGRGQRELIIGDRQTGKTAIAIDTILNQKQMNSRGTNESETLYCVYVAIGQKRSTVAQLVQILSEANALEYSILVAATASDPAPLQFLAPYSGCAMGEYFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKRSDQTGAGSLTALPVIETQAGDVSAYIPTNVISITDGQICLETELFYRGIRPAINVGLSVSRVGSAAQLKAMKQVCGSLKLELAQYREVAAFAQFGSDLDAATQALLNRGARLTEVSKQPQYEPLPIEKQIVVIYAAVNGFCDRMPLDRISQYEKAILSTINPELLKSFNEKGGLTNERKIELDAFLKQTAKEIN
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Subunits alpha and beta form the catalytic core in F(1).  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.  Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
What are the official names of this protein?
ATP synthase subunit alpha, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.
Protein: ARLS_STAAN
Sequence: MTKRKLRNNWIIVTTMITFVTIFLFCLIIIFFLKDTLHNSELDDAERSSSDINNLFHSKPVKDISALDLNASLGNFQEIIIYDEHNNKLFETSNDNTVRVEPGYEHRYFDRVIKKRYKGIEYLIIKEPITTQDFKGYSLLIHSLENYDNIVKSLYIIALAFGVIATIITATISYVFSTQITKPLVSLSNKMIEIRRDGFQNKLQLNTNYEEIDNLANTFNEMMSQIEESFNQQRQFVEDASHELRTPLQIIQGHLNLIQRWGKKDPAVLEESLNISIEEMNRIIKLVEELLELTKGDVNDISSEAQTVHINDEIRSRIHSLKQLHPDYQFDTDLTSKNLEIKMKPHQFEQLFLIFIDNAIKYDVKNKKIKVKTRLKNKQKIIEITDHGIGIPEEDQDFIFDRFYRVDKSRSRSQGGNGLGLSIAQKIIQLNGGSIKIKSEINKGTTFKIIF
What is the function of this protein?
Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence.  ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).
What are the official names of this protein?
Signal transduction histidine-protein kinase ArlS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CAF17_NEUCR
Sequence: MQPATRSIAVAGPASAALRTATTPFICLGCRSVQRKQQRRLFSSTVSTQTDLRAGLTKLTSRRLISVSGPDASKFLQGVITNNINAPHNANGFYTGFLTAQGRVVHDVIIYPDDLGPEPGKQSFLIEVDADEAATLHKHIKRYKLRSKFNLKLLDPEERALYHSWNDVDQAGPWTKLIDEVQNAGNARAVPDPRVPAFGSRVVVNQTSSSSPLTDGDLTPESSYHLRRFLLGIPEGQSEIISGTALPLESNMDVMNGIDFRKGCYVGQELTIRTKHRGVVRKRILPCILYYEGAAPEIPADGPGQLEALEKLLKPEVEQGVKAEMIPQGASIDKVDKKSRSAPGKWLRGIGNVGLALCRLEVMTDTVLPGETPGTYSPEQDFVVSLGGEEGSEVEAKKVKVKAFVPFWLKDVWRIEAEKAEEERRMREELLRDRGLDVE
What are the official names of this protein?
Putative transferase caf-17, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the GcvT family. CAF17 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.