PharMolix/UniProtQA huggingface dataset:
Protein: CO4A4_HUMAN
Sequence: MWSLHIVLMRCSFRLTKSLATGPWSLILILFSVQYVYGSGKKYIGPCGGRDCSVCHCVPEKGSRGPPGPPGPQGPIGPLGAPGPIGLSGEKGMRGDRGPPGAAGDKGDKGPTGVPGFPGLDGIPGHPGPPGPRGKPGMSGHNGSRGDPGFPGGRGALGPGGPLGHPGEKGEKGNSVFILGAVKGIQGDRGDPGLPGLPGSWGAGGPAGPTGYPGEPGLVGPPGQPGRPGLKGNPGVGVKGQMGDPGEVGQQGSPGPTLLVEPPDFCLYKGEKGIKGIPGMVGLPGPPGRKGESGIGAKGEKGIPGFPGPRGDPGSYGSPGFPGLKGELGLVGDPGLFGLIGPKGDPGNRGHPGPPGVLVTPPLPLKGPPGDPGFPGRYGETGDVGPPGPPGLLGRPGEACAGMIGPPGPQGFPGLPGLPGEAGIPGRPDSAPGKPGKPGSPGLPGAPGLQGLPGSSVIYCSVGNPGPQGIKGKVGPPGGRGPKGEKGNEGLCACEPGPMGPPGPPGLPGRQGSKGDLGLPGWLGTKGDPGPPGAEGPPGLPGKHGASGPPGNKGAKGDMVVSRVKGHKGERGPDGPPGFPGQPGSHGRDGHAGEKGDPGPPGDHEDATPGGKGFPGPLGPPGKAGPVGPPGLGFPGPPGERGHPGVPGHPGVRGPDGLKGQKGDTISCNVTYPGRHGPPGFDGPPGPKGFPGPQGAPGLSGSDGHKGRPGTPGTAEIPGPPGFRGDMGDPGFGGEKGSSPVGPPGPPGSPGVNGQKGIPGDPAFGHLGPPGKRGLSGVPGIKGPRGDPGCPGAEGPAGIPGFLGLKGPKGREGHAGFPGVPGPPGHSCERGAPGIPGQPGLPGYPGSPGAPGGKGQPGDVGPPGPAGMKGLPGLPGRPGAHGPPGLPGIPGPFGDDGLPGPPGPKGPRGLPGFPGFPGERGKPGAEGCPGAKGEPGEKGMSGLPGDRGLRGAKGAIGPPGDEGEMAIISQKGTPGEPGPPGDDGFPGERGDKGTPGMQGRRGEPGRYGPPGFHRGEPGEKGQPGPPGPPGPPGSTGLRGFIGFPGLPGDQGEPGSPGPPGFSGIDGARGPKGNKGDPASHFGPPGPKGEPGSPGCPGHFGASGEQGLPGIQGPRGSPGRPGPPGSSGPPGCPGDHGMPGLRGQPGEMGDPGPRGLQGDPGIPGPPGIKGPSGSPGLNGLHGLKGQKGTKGASGLHDVGPPGPVGIPGLKGERGDPGSPGISPPGPRGKKGPPGPPGSSGPPGPAGATGRAPKDIPDPGPPGDQGPPGPDGPRGAPGPPGLPGSVDLLRGEPGDCGLPGPPGPPGPPGPPGYKGFPGCDGKDGQKGPVGFPGPQGPHGFPGPPGEKGLPGPPGRKGPTGLPGPRGEPGPPADVDDCPRIPGLPGAPGMRGPEGAMGLPGMRGPSGPGCKGEPGLDGRRGVDGVPGSPGPPGRKGDTGEDGYPGGPGPPGPIGDPGPKGFGPGYLGGFLLVLHSQTDQEPTCPLGMPRLWTGYSLLYLEGQEKAHNQDLGLAGSCLPVFSTLPFAYCNIHQVCHYAQRNDRSYWLASAAPLPMMPLSEEAIRPYVSRCAVCEAPAQAVAVHSQDQSIPPCPQTWRSLWIGYSFLMHTGAGDQGGGQALMSPGSCLEDFRAAPFLECQGRQGTCHFFANKYSFWLTTVKADLQFSSAPAPDTLKESQAQRQKISRCQVCVKYS
What is the function of this protein?
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
What are the official names of this protein?
Collagen alpha-4(IV) chain.
What is the protein family that this protein belongs to?
Belongs to the type IV collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL).
Protein: GREA_UREPA
Sequence: MAKYTISKHRLEELQLELREILDVKWPAITKQLQDAREQGDLSENADYDAAKNEQAALKKRKDEIEEILENYELIEDVLRSTDEVSIGSTIEIYNYQKDCEEVITLVGSMDSDPFANKISIDTPLGKALVKQKKGTEVTVHTLASPYKVKIIKIID
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: YR290_MIMIV
Sequence: MDDYEKSKVLTKRYKKLKKLLKMVYGYDNFRPRQYEIINKVINGEDVCAILMTSAGKSLCFQIPALYLDKPAIIISPLISLMEDQRLILEKLGISSCCYNSNVENKAQMRKDIMQFKYKFIYVSPESVVHLKDLIVKLEDFQGISLIAIDEAHCISAYGFDFRTAYREITFFKEILPNVPILALTATATNIVAKDICKVLQLKTNEPIKASFDRPNLYLEVRTKSKNPANDIVPIINKYPNQSVIIYCLTKKETQKIADILTVHKVVCGIYHAGLSNEHKTKTHTNFINNKIKIVVATIAFGMGINKPDVRVVIHYGAPKNIEGYYQEIGRAGRDGEKSYCYAFYNFQDFMIQRRFISQNNNPNYQKTQLALLEQMKKYVTLRTCRRKILLEYFDEETKEKCDFCDNCCGVHKNIVNENVTSKQNVQSEAKLIIELIESIPNRNFGVNMYINILRGSKNKAISPAIRKNKYYGLGSKHSSEWWKEVFDNLIKQGFLQSVSLKTGKFPIQVVKVTNKGVTWVSMADLGSLLDNIDNSVKLDPVEMVASV
What are the official names of this protein?
Putative ATP-dependent RNA helicase R290.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
Protein: THI5_YEAST
Sequence: MSTDKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDMAILEPTNPSDVTELIGSGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITEDFQSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEGKIDAGIGIECMQQVELEEYLAKQGRPASDAKMLRIDKLACLGCCCFCTVLYICNDEFLKKNPEKVRKFLKAIKKATDYVLADPVKAWKEYIDFKPQLNNDLSYKQYQRCYAYFSSSLYNVHRDWKKVTGYGKRLAILPPDYVSNYTNEYLSWPEPEEVSDPLEAQRLMAIHQEKCRQEGTFKRLALPA
What is the function of this protein?
Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway.  Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP).  The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.
What are the official names of this protein?
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5, HMP-P synthase, Hydroxymethylpyrimidine phosphate synthase, Thiamine biosynthesis protein 5, Thiamine pyrimidine synthase.
What is the protein family that this protein belongs to?
Belongs to the NMT1/THI5 family.
Protein: GNAI2_HUMAN
Sequence: MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVLPDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEAASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
What is the function of this protein?
Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-2, Adenylate cyclase-inhibiting G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
Protein: Y695_STAAE
Sequence: MENKYTHGVLFYHEHSGLKNINQGIGEVTTALSSICKHLSIQLSENEGDIIKYCQEIKTKNYAKDVDILFILGGDGTVNELINGVMTHDLQLPIGILPGGTFNDFTKTLNIAPNHKQASEQMISAQVGTYDVIKINNQYALNFVGLGLIVQNAENVQDGSKDIFGKLSYIGSTVKTLLNPTQFNYQLSIDDKTYSGETTMILTANGPFIGGSRIPLTDLSPQDGELNTFIFNEQSFSILNDIFKKRDSMNWNEITQGIEHIPGKKISLTTDPAMKVDIDGEISLETPIDIEVIPNAIQLLTVNDL
What is the function of this protein?
May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG).
What are the official names of this protein?
Putative lipid kinase NWMN_0695.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family.
Protein: DADA_YERPB
Sequence: MRVVILGSGVVGVTSAWYLAKEGHDVTVIDRQDGPAQETSAGNAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAIRLDGSSLQLRWMWQMLRNCDTSHYMVNKSRMVRLAEYSRDCLKDLRAATGIQYEGRQGGTLQLFRTEQQFDNAAKDIAVLDDAGVPYSLLTAEQLATVEPALAKVAHKLTGGLRLPNDETGDCKLFTERLAKMAEQAGVKFIFNRSVDKLLVEGDQIAGVLCGDDIIKADAYVVAFGAYSTALLAGLVSIPVYPLKGYSLTIPITDPASAPFSTVLDETYKIAITRFDDRIRVGGMAEIVGFNTQLAPARRETLEMVVRDLYPHGGDISQAVFWSGLRPMTPDGTPIVGRTPLKNLYLNTGHGTLGWTMACGSGQLLADIIQGRRPAIVADDLSVARYRAGFQPLNIAPLHDIHPIR
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: KCY_SULIA
Sequence: MIIIISGPPGSGKTSVAIKLANELSYKFISAGKIFRDIAQKMGLDIINLNKVAESNFDIDKMVDKKIFEFILSEKNLIIESHIAGWLFREYTNIAIYLWAPLKIRANRIAIRDKISYDQAISQIIKREYMHYKRFNKFYGIDINDLSVFDLVINTSNVDVNNIVKLILTYLSSVSQNPQPLKEKDINDK
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOA_EUGST
Sequence: MKLFKISLIKNYFIEGSSYGLFNFDLQDFSNCDRVAWGNLLRRTLLKDLEGLRFGNSSIFISRSFSKIPYYHRVNEYSDIEQVNPSLLQVFSNFRNLHIFSSKPFYRKTSYSMIKVLTSRSYFSKDILLPNNLYVVNPDVQLFEFLSKRYKLRIISEICKGSGKSFSPIKKVNYVVEGIPYASLLLEIYTDLRANALSSLLATLRLINPKFAA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COPG_ANOGA
Sequence: MWRTKRGRTRRRDAGGNPWQNLEKTSVLQETRMFNETPVNARKCTHILTKILYLLNQGEVLGTREATECFFAMTKLFQSKDVVMRRMVYLGIKELSPIADDVIIVTSSLTKDMTGKEDLYRAPAIRALCSITDSTMLQAVERYMKQCIVDRNAPVSSGALVSSLHLASTAGEVVKRWANEAQEALNSDNIMVQYHGLGLLYHIRKADRLAVTKLVNKLTRQHLRSPYATCFLIRIACKIMEEEDASGNATEDSPLFNFVECCLRNKSEMVVYEAAHAVVNLKRTNPRELSTAVSILQLFCGSSKATLRFAAVRTMNKVAMLHPPAVNVCNLDLEGLIADSNRSVATLAITTLLKTGAESSVERLMKQIATFVAEISDEFKLVVVQAIRSLCTKFPRKHAVTMNFLSGMLREEGGLEYKTSIVDTIILIIEENPDAKEAGLGHLCEFIEDCEHTSLAVRILHLLGKEGPYSKCPSRYIRFIYNRVILENATVRAAAVAAIAQFGACCPDLLPNVLVLLNRCQMDCDDEVRDRATYYYTILNQSNPELNKRFIADHEIVSLPLLEKSLNEHLKGPLAERFDLSIVPKSQVIQPEVNEEVMIMNKAAPKIARVNREEVNTEKLLAIPGIHHVGALHKSCAPVQLTESETEYTVSCIKHCFAHHIVFQFDCVNTLSDQLLENVRVDLELPEGFVSRAVIPCAKLPYGDKESTYVIVQFPEDVPSSIATLGATLRFLVKDCDPATGQPDSDEGYNDEYILEDIEVTVADQMQKSKKQNFLAAWESADTEEWVEAEDTFELSSVTSLQDAVNTILKFLGLAPANLSENVPDGTFRGGVEVLVRSKLAVADGVTMQLTVRSTDMDVAELITSAVG
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit gamma, Gamma-coat protein, Gamma-COP.
What is the protein family that this protein belongs to?
Belongs to the COPG family.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: KGUA_STRT2
Sequence: MSERGLLIVFSGPSGVGKGTVRQEIFSKSDHKFEYSVSMTTRAQRPGEVDGKDYFFRSREEFEELIRNGQMLEYAEYVGNYYGTPLAYVNETLDKGIDVFLEIEVQGALQVKKKVPDAVFIFLTPPDLNELEERLVGRGTDSEEVIAQRIERAREEIALMSEYDYTIVNDEVPLAAERVKRVIEAEHFRVERVIGHYRNMISDKRLSDK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PETD_SYNJA
Sequence: MPVSKQVIATEAITRKVDLDNPKVLAKLKKNMGHMTYGEPAWPNDLLFMFPVVILGTIGVIVGLAVMDPAGVGEPADPFATPLEILPEWYLYPAFHILRIAPNKLLGIALMSAIPVGLLFVPFIENVNKFQNPLRRPVATTVFLIGTLVTLYLGIGATLPLDKWVTLGLF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex subunit 4, 17 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetD subfamily.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: EFTU_PICGU
Sequence: MFKNLAGSFRAVSRVAFKTRPSLVRSYAAFDRSKPHVNIGTIGHVDHGKTTLTAAITKVLSEKGGANFLDYGSIDRAPEERARGITISTAHVEYQTDKRHYAHVDCPGHADYIKNMITGAAQMDGAIIVVAATDGQMPQTREHLLLARQVGVQHLVVFVNKVDTIDDPEMLELVEMEMRELLSQYGFDGDNTPVIMGSALCALESKQPEIGVQAIEKLLDAVDEHIPTPTRDLEQPFLLPVEDVFSISGRGTVVTGRVERGSLKKGEEIEIVGDFDKPFKTTVTGIEMFKKELDAAMAGDNAGILLRGVKRDDVKRGMVLAKPSTVTSHKKVLASLYILSKEEGGRHSPFGENYKPQLFIRTTDVTGTLRFPAGEGVDHSQMVMPGDNVEMEIELVRKTPLEVNQRFNIREGGKTVGTGLVTRIIE
What is the function of this protein?
G-protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.  In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed.  The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA.  Required for mitochondrial protein biosynthesis and maintenance of mitochondrial DNA (By similarity).
What are the official names of this protein?
Elongation factor Tu, mitochondrial, tufM.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: Y304_ARCFU
Sequence: MIVSSEAFLNLNINEILKFRKFLNIRVSKIVCYLRRQDLWLESGYKQAVKSPFNRSTEKFKIKYFDYYSKLSNWKQAFPEAEIIVRIYDRKLFPEGNVILDFLQALGIDMPEAREYKIEANPSLSHLSTLVMRRINEELNLSPQDRWKVVNYLLELDRREGSILKTFFTLEERIKFLEQFRESNEKLFREYFGTKNQFVLSEEEIEFYRQQDQIPREVIERAIEERYQKVLEFMKREGIMAKEKIFPKVNVNYLPEANLEFFRIDVLQANLLNGRLILSGLLLPKNAEGVKLTVKDAEGIKEIQWGLPSPIFGELHPDNPIAKNARFRVDNVVPDLEKPIEVFLNGEKVAEIIIDGSRG
What are the official names of this protein?
Uncharacterized protein AF_0304.
Protein: Y2288_MYCMM
Sequence: MTLPLLGPMTLSGFAHSWFFLFIFVIAGLIAVYVVLQLARQKRMLRFANMELLESVAPQRPSRFRHIPAMLLALSLVLFTVAMAGPTHDVRIPRNRAVVMLVIDVSQSMRATDVEPNRMVAAQEAAKQFADELTPGINLGLIAYAGTATVLVSPTTNREATKAALDKLQFADRTATGEAIFTALQAIATVGAVIGGGDTPPPARIVLFSDGKETMPTNPDNPKGAYTAARTAKDQGVPISTISFGTPYGFVEINDQRQPVPVDDETMKKVAQLSGGNSYNAATLAELNSVYASLQQQIGYETIRGDASMGWLRLGALVLVAAALAALLINRRLPT
What are the official names of this protein?
UPF0353 protein MMAR_2288.
What is the protein family that this protein belongs to?
Belongs to the UPF0353 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: I329L_ASFB7
Sequence: MLRVFIFFVFLGSGLTGRIKPQVTCKYFISENNTWYKYNVTILNSSIILPAYNTIPSNAAGISCTCHDIDYLQKNNISIHYNTSILKTFQDIRIIRCGMKNISEIAGGFGKELKFLDLRYNDLQVIDYNILRKLIRSNTPTYLYYNNLMCGKRNCPLYYFLLKQEQTYLKRLPQFFLRRISFSNNNTYLYHFLSCGNKPGHEFLEYQTKYCRTKFPEINITVNQLIAKKNTERYKSCYPLVFISILCSCISFLFLFICLLRSICKKYSCTKQDKSSHNYIPLIPSYTFSLKKHRHPETAVVEDHTTSANSPIVYIPTTEEKKVSCSRRK
What is the function of this protein?
Viral TLR3 homolog that probably prevents TLR3 dimerization and subsequent induction of IFN (PubMed:21280117, PubMed:21203785).  Inhibits dsRNA-stimulated activation of NF-kB and IRF3 (PubMed:21203785).
What are the official names of this protein?
Transmembrane protein I329L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus I329L family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein.
Protein: LONP2_YARLI
Sequence: MDATLPLLTLPADTVVLPGVSMKVGLSKETAVAMLKLFEKPKDKDVAYSKATQDLMSSVNKLQAFFKLKRTSADGYRNASLITIACVPRITQKQIKETGENNEAGAHDSESVTPVLGTNSTEVNTSVYSFGTVCRIVRFERSGTEDFQIVVEGLSRLELGQLVDKSGLVPTARIKVRVDEDGESASSDESSDKEPTWSKTELSQLEVLHASAKEIIDLAAKSNATQFSKLMASQTTVAASVMKQLTKLGPNPGSARDTRKTAGMLVDLLMAILPTDFEDKIAVLAAFSIPERIAKGSEILKTKLDMMKITEKIDSTVDSKMNKQQREYLLRQKMRAIQEELGETDDRGEDDDLKELTQKLQSLKLSPEADKVVSRELKRIKRMPPTQAEYQVCRTYLETIAELPWDKCTEDTVVTVDQARTILDNDHYGLSHIKKRLLEYLAVLRLKSLRSESEVAQEETAAAASSEGPNGQLDDSAKPIDYSNRAPILLLVGPPGVGKTSLAKSVARALGRKFQRLSLGGVRDESEIRGHRRTYVGAMPGLFIQGLRQVGVNNPVVLLDEIDKIGGANFHGDPAAAMLEVLDPEQNATFRDHYINFPVDLSKCIFIATANNLDTIPAPLLDRMETVHLEGYTYMEKLHIAKKYLVPKQTKANGLEVDQVVIPDDVLLHICTKYTREAGVRNLERKIGAVCRAKAVDYAKSLSADDGELITVVDEAKKGAHSSYDPVVTIENLTDILGMEVYTDEDAQDAKEEPNSSHIGVVNGLAYMGTGNGGLLKFEATQMPGKGQLKLTGKLGDVIQESAQIALSWVKSNAAALHIDTDFDKVDIHLHAPAGAIPKDGPSAGVAMTLAFVSLFMGKPIPPSIAMTGEMTLRGRVLPVGGIREKLLGAHLAGVNRIMLPLANKRDVDEEQRKGGDGGVLDKMEISYVKYMWDVLELVWDLRFDPMIESRL
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix.  Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
What are the official names of this protein?
Lon protease homolog 2, peroxisomal.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Peroxisome matrix.
Protein: Y3137_VIBCH
Sequence: MLYAKALSIGDEIGFFSPSSPATAFAPNRFQRAKAYLKAQGFELVEGSLTGKSDYYRSGSIRERAEELNQLIRDPNVRCIMPTIGGNNSNSLLPYIDYEALRNDPKIIIGYSDVTALLLGIYAQTGLITFYGPALVASFGEYPPLVDETFHSFIDLLCSETNQYQYTMPSSWTDIKHDWETQHSAKPVYPNEWQFIGKGKVTGRIIGGNLNTMAGIWGSRYMPEIKVGDILLIEDSLKGIENVERSFAHLAACGVFERVSAIILGKHELFDNKGTGRTPLDVLIEVLADKNVPIFYGFDSCHTHPMLVTPLGVRGTIDFDNHTFKLEDRWVKAK
What are the official names of this protein?
Putative carboxypeptidase VC_A0337.
What is the protein family that this protein belongs to?
Belongs to the peptidase S66 family.
Protein: ENV_FIVU2
Sequence: MAEGFAVNRQWIGPEEAEELLDFDIATQMNEEGPLNPGINLFRVPGITETEKQEYCNILQPKLQDLRNEIQEVKLEEGNAGKFRRARFLRYSDETILSLIHLFIGYCTYLCKRNKLGTLVHNIDIEAPQEECYSNRERGTTVNIKYSRRCCIGTTALYLLLLTGIIIYTQTTQAQVVWRLPPLVVPVEESEIIFWDCWAPEEPACQDFLGAMIYLKASTNISIQEGPTLGNWAREIWGTLFKKATRQCRRGRIWRRWNETITGPSGCANNTCYNISVIVPDYQCYLDRVDTWLQGKVNISLCLTGGKMLYNKDTKQLSYCTDPLQIPLINYTFGPNQTCMWNTSQIQDSDIPKCGWWNQIAYYNSCRWEQTDVKFHCQRTQSQPGTWLRTISSWKQKNRWEWRPDFESEKVRVSLQCNTTKNLTFAMRSSGDYGEVTGAWIEFGCHRNKSKLHSDARFRIRCRWNVGDNTSLIDTCGNDPNVSGANPVDCTMYANRMYNCSLQNGFTMKVDDLIMHFNMTKAVEMYNIAGNWSCTSDLPSTWGYMNCNCTNSSSTDSNKMACPKRQGILRNWYNPVAGLRQSLEKYQVVKQPDYLVVPREVMEYKPRRKRAAIHVMLALATVLSMAGAGTGATAIGMVTQYHQVLATHQETIEKITEALKVNNLRLVTLEHQVLVIGLKVEAIEKFLYTAFAMQELGCNQNQFFCKVPPELWQRYNMTINQTIWNHGNITLGEWYNQTKDLQQKFYEIIMDMEQNNVQGRKGLQQLQEWEDWVGWLGNIPRYLKGLLGGILGIGLGVLLLILCLPTLVDCIRNCISKVLGYTVIAMPEVEEEEIQPPMELRRNGRQCDMSEKEEE
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp150, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N- terminus of Gag (By similarity).
Protein: FTMB_ASPFU
Sequence: MPPAPPDQKPCHQLQPAPYRALSESILFGSVDEERWWHSTAPILSRLLISSNYDVDVQYKYLSLYRHLVLPALGPYPQRDPETGIIATQWRSGMVLTGLPIEFSNNVARALIRIGVDPVTADSGTAQDPFNTTRPKVYLETAARLLPGVDLTRFYEFETELVITKAEEAVLQANPDLFRSPWKSQILTAMDLQKSGTVLVKAYFYPQPKSAVTGRSTEDLLVNAIRKVDREGRFETQLANLQRYIERRRRGLHVPGVTADKPPATAADKAFDACSFFPHFLSTDLVEPGKSRVKFYASERHVNLQMVEDIWTFGGLRRDPDALRGLELLRHFWADIQMREGYYTMPRGFCELGKSSAGFEAPMMFHFHLDGSQSPFPDPQMYVCVFGMNSRKLVEGLTTFYRRVGWEEMASHYQGNFLANYPDEDFEKAAHLCAYVSFAYKNGGAYVTLYNHSFNPVGDVSFPN
What is the function of this protein?
Brevianamide F prenyltransferase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:16000710, PubMed:23649274).  The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA (PubMed:16755625).  Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (PubMed:16000710, PubMed:19113967, PubMed:21105662, PubMed:23090579).  FtmPT1/ftmB shows also tryptophan aminopeptidase activity with preference for linear peptides containing a tryptophanyl moiety at the N-terminus (PubMed:18635009).  The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (PubMed:19226505).  The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable).  FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (PubMed:18683158).  Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (PubMed:19763315).  In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
What are the official names of this protein?
Tryprostatin B synthase ftmPT1, Brevianamide F prenyltransferase ftmPT1, Fumitremorgin biosynthesis protein B, Tryptophan aminopeptidase ftmPT1.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.
Protein: MCES_SCHPO
Sequence: MSSSNSRVHEEQPPTENRRYARPTAQMNRVIEQQPRRRDYFQNNDNSGRRGYNRHENNGNAQDVVRSHYNARPDLGYKKRQFSPIIQLKRFNNWIKSVLIQKFAPHASDYPILVLDMGCGKGGDLIKWDKAGIDGYIGIDIAEVSVNQAKKRYREMHASFDALFYAGDCFSSSINELLPPDQRKFDVVSLQFCMHYAFESEEKVRVLLGNVSKCLPRGGVMIGTIPNSDVIVKHIKMLKPGEKEWGNDIYKVRFPESPPRSFRPPYGIQYYFYLEDAVTDVPEYVVPFEAFRAVAEGYNLELIWVKPFLDILNEEKNSETYGPLMDRMKVVDNEGHRGIGGQEKEAAGFYLAFAFEKRGI
What is the function of this protein?
Responsible for methylating the 5'-cap structure of mRNAs.
What are the official names of this protein?
mRNA cap guanine-N7 methyltransferase, mRNA (guanine-N(7))-methyltransferase, mRNA cap methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y010_MYCGE
Sequence: MDVRTERLNELFFVYHKNLKNQSKSKYSRAVNYLKRRGFNLQDFLKVGGGVGYLQNKEWLNLPLYSFDGNLIGFLNRKVSYKKEFLYTPFNKPPSKSEAFVGLRELVIKDNSIYLVEGDFDWLAFRKAGILNSLPLCGLTISNQQVQWLKQKKIKKIFICFDNDLAGKNGAKNLKEYLTKQGFITKVIEIKAAAKDWNDLFLLNNSNWSAVLTNQLLF
What are the official names of this protein?
Uncharacterized protein MG010.