Protein: ATM_DROME
Sequence: MSALLNEIQRILGDLQSGKAASRNKGIQQLDEKLSSCREDLDKLFLSKTSDISWTTIFEASKEALFKQAGNLEDVNEKVFKTLAGKNYLYDNVLEKITQFNLEAGSQTSGNGHFLAKTSIFSAFEDGIKMRVVVKYFGDRILSLLEKGIYSSVSYVRDLKINEYSRILSYLFELNVDMDEVLRTRILKCITRTVSLAKDRVQLHVDLVEYLPELSSFALSAFGARKTEIVRVYLIFASELAVNYNHQLNVHMQEILPKLCEYHDEDAFRDDTRNLFFQCVSKSLHSMYLKMDMCDFNTLGVPVHEKWPQTLLRLKTIVNVEIRKNSWARCKNALLSNNKFSDPFIKMSALAMYIVLWHLETKKADENGEGDAPKKIPKPADKMETIFSLIDKKENTFNDVWLAIFTEILQLSSVILNVANYQMALTTVAEIMQMYGNAKNLRNLRLCLAHLLTKEQELLHSKSIREDFLGELWSQMANQLISETTTNSEEIKEKQLVLQMLIRHNKLNQKLSSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKASADLEPIIAWAYGSADRFIAAQMIHNIDSIDAQLQADTFAISIINFLDVQQLRQISQSEHIVPSTERNLLAYKYNEQLICFDKDYATPFESITHIQSETKNCLIQSNYDCLMRGLNFEIAKENKPAAIIKNLNSLLKLICTMERLLHYKVFDADTYTGCPLIKRIGLYLSHIEFQLKANGAEILDKSDLPEILRLEIYVLDVFRTNLVLLDYLERQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHRDEAFEHIVKVTMRWHPQDVLIVTKMLCSCQTISEASSSWLVSKLKTLFQQHHQDAELMDKVVQHMPTIFYFVRHKENHLDDMLMALNSLLRIAIKKSYTSNLTAKIVRCVGLIAQRCPDIYLLENFAVICKSTAKFITMPTLEVRFATLFTFTILLESNCVTSDAIGHSRTHWDFCQELYESIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSSFHQEIALKELLHHCALRRLTEREFISLQSMSSCHRQTVRDLIRPFAAILLHHWSSKRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCSKSISEELALPILASFLLIKNSSCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISMLHDPQEMMRLFGSLAICNRTASWYSLSGESLFKCLNFHIDPEMRPSMDSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVADAVYDAARKNETIVTQCSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNHFGDIAKLLSNFQLCCEAKEVREKTMSIVMYILESKKGHINLNSFLEETTDCEFLKPLREDCKSSQPNIDRADVANYLRSFLLSPTPERLRDLRTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLAQIGPLKISTVSYYFQTDFEAFEKSNGEPMEAFLGVVCHSLDTSLFQFDPKTHEGLVSVAIQVVNSKPGSNIMERYKNLRIFADKSTASTFLHSNKQIRRIDWLSILKATKSLSYEPWMCAFVSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIKLLLENSLEHVESLSQMLDYFFEGFTSSTAPNSQEIFRNKRAIKKFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSIMYLELWACSESPKSKADFLDNECFQDGAKKAYESIGCLDAIPGFVNPMRSRLDFLGHGSNLSTILLESDHLDRASGQLCIDIMKGNGLWSFAKLQQHQNIEPDYEIFWRLGQWDSLTDPKHQQNQTVVRTSLDLEQEFKRHHFVALRSIGQREEENSLSAIEQAYSCVRDILMEISVECLQSVYKYLTWLCSLQQAEDFCQIQFGTQLDPASTTKIFRKWQTELELKYGNFSCKEYVIAHQIALLKLAGTRASRRMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLRELPNIRESIKISVLLEDAEINLKMGNQQIAKAILDYVTNNNEFVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIFDWHQLDAYASKQRTAAYATIAKYADREYQQLHDYRHSQEYQTLKDIIEQNRQTAEKVTQRENQDRRVISVQMKRYASLDEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGFSSAAIYRIISLWFTNATSKQCQECIKDEILTVPSYKFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERSGIARKIIAMICEKNGTAGECSKQLESLLPALITFANEGKTNDNRPVSDSVRNKQFDKVRRWRNLNAVHCPTLELPVMPSKEYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQSPQQSGEESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVERLINEATLPSNLCMLFPGWDPHL
What is the function of this protein?
Serine/threonine-protein kinase which recognizes the substrate consensus sequence [ST]-Q.  Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation.  Required for female fertility.  Protects telomeres from fusion, maybe by recruiting or maintaining chromatin-modifying complexes such as Su(var)205/HP1.  May activate checkpoint signaling in response to DNA double-stranded breaks induced by low-dose ionizing radiation.  May phosphorylate histone H2AV.
What are the official names of this protein?
Serine/threonine-protein kinase ATM, Telomere fusion protein.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. ATM subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.