PharMolix/UniProtQA huggingface dataset:
Protein: UVRC_SALTY
Sequence: MSEIFDAKAFLKTVTSQPGVYRMYDAGGTVIYVGKAKDLKKRLSSYFRSNLASRKTEALVAQIQHIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPFIFLSGDTHPRLAMHRGAKHAKGEYFGPFPNGYAVRETLALLQKIFPIRQCENSVYRNRSRPCLQYQIGRCLGPCVAGLVSEEEYAQQVEYVRLFLSGKDDQVLTQLIARMEKASQDLAFEEAARIRDQIQAVRRVTEKQFVSNAGDDLDVIGVAFDAGMACVHVLFIRQGKVLGSRSYFPKVPGGTELGEVVETFVGQFYLQGSQMRTLPGEILLDFNLSDKTLLADSLSELAGRRIHVQTKPRGDRARYLKLARTNAATALITKLSQQSTITQRLSALAAVLKLPAIKRMECFDISHTMGEQTVASCVVFDANGPLRAEYRRYNIAGITPGDDYAAMNQVLRRRYGKAIEESKIPDVILIDGGKGQLAQAKAVFAELDVPWDKHRPLLLGVAKGADRKAGLETLFFEPEGEGFSLPPDSPALHVIQHIRDESHDHAIGGHRKKRAKVKNTSTLETIEGVGPKRRQMLLKYMGGLQGLRNASVEEIAKVPGISQGLAEKIFWSLKH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y030_SULIK
Sequence: MIKEYYGAETFILNKDFAYILVIGTTDVSLIPGLTIAGATPELTHFTPAADAEYVLLGKCKSINTIPVSPTGIPTPALLTRASLSFINPLKIVVNAGSRIVPKIPYIDLQGEPGKDIRKQALSMEKVNNIIENSIKLGEELSNEYELIMIGESIPAGTTTAMATLLALGYDAMDKVSSASPDNPKELKRKVVEEALRNLPTDPLQRLAKVSDPVLLGVAGTSLGFKGKILLAGGTQMTAAAAIINEFDKNKLKDITIGTTKWIVEDKFADMLSLAKQVGVKVLASMLDLSISAYEGIRAYEKGYVKEGVGAGGSAIMALVRGVSNNTLVRKIDELYGELVGSNNLHI
What are the official names of this protein?
UPF0284 protein M164_0030.
What is the protein family that this protein belongs to?
Belongs to the UPF0284 family.
Protein: RL11_METBF
Sequence: MTSIVEALVPGGKANPGPPLGPALGPLGVNIKEVVEKINEKTRDYNGMQVPVKVIVDDKKNVEIEVGTPPTASLIMKELGIQKGSGNAGSEVVGNISISQVAKIARMKKEDVLSYDLKATMKEVMGTCVPMGVTVEGVEARDSQKALDQGKFDDLLAGEEW
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: TFDD_DELAC
Sequence: MKIEAISTTIVDVPTRRPLQMSFTTVHKQSYVIVQVTAGGLVGIGEGGSVGGPTWGSESAETIKVIIDNYLAPLLIGKDASNLSEARALMDRAVTGNLSAKAAIDIALHDLKARALNLSIADLIGGTMRKSIPIAWTLASGDTARDIDSALEMIEARRHNRFKVKLGARTPAQDLEHIRSIVKAVGDKASVRVDVNQGWDEQTASIWIPRLEEAGVELVEQPVPRANFGALRRLTEQNGVAILADESLSSLSSAFELARDRAVDAFSLKLCNMGGIANTLKVAAIAEAAGISSYGGTMLDSTVGTAAALHVYATLPSLPYGCELIGPWVLSDRLTQQDLEIKDFEVHLPVGSGLGVDLDHDKVRHYTRAA
What are the official names of this protein?
Chloromuconate cycloisomerase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Protein: OXLA_BOTSC
Sequence: SCADDRNPLEECFQETDYEEFLEIARNGLKATSNPKHVVIVGAGMSGLSAAYVLAGAGHQVTVLEASERAGGRVRTYRNDKEGWYANLGPMRLPEKHRIVREYITKFGLQLNEFSQENENAWYFIKNIRKRVGEVKKDPGLLQYPVKPSEEGKSAGQLYEESLGKVVEELKRTNCSYILDKYDTYSTKEYLIKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDNIFGYEKRFNEIVDGMDKLPTSMYQAIEEKVRFNARVIKIQQNDNEVTVTYQTSENEMSPVTADYVIVCTTSRAARRITFEPPLPPKKAHALRSVHYRSGTKIFLTCTKKFWEDDGIHGGKSTTDLPSRFVYYPNHDFSSGSAVIMAYGIGDDANFFQALDHKDCGDTVINDLSLIHQLTKEEIQSFCYLSKIQRWSLDKYAMGGITTFTPYQFQHFSEALTAPFKRIYFAGEYTAQFHGWIDSTIKSGLTAARDVNRASENPSGIHLSNDN
What is the function of this protein?
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:24875315).  Shows activity on L-Leu (PubMed:24875315).  Damage cell membranes of the Gram-positive bacteria S. aureus (MIC=4 ug/ml and MBC=8 ug/ml) and the Gram-negative bacteria A. baumanni (MIC=2 ug/ml and MBC=4 ug/ml) (PubMed:24875315).  This antibacterial activity is dependent on the production of hydrogen peroxyde, since it is inhibited by catalase, a hydrogen peroxyde scavenger (PubMed:24875315).
What are the official names of this protein?
L-amino acid oxidase Bs29, BsLAAO, LAO.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family. FIG1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GSH1_SHEAM
Sequence: MTAFNDRLGALSDAEGRKALAGLRRGLEREALRITSCCQLALDPHPKALGSALTHSRITTDYSEALLEFITPVSGNIEDLLEGLTETHAYTLKHLDGQKLWPVSMPCYVGDVKDIPIAQYGTSNTGRMKTLYRKGLTYRYGALMQIISGVHFNFSLSSDLWPRLHALSGSSLSLDEFISESYFGLIRNYRRLVWVLPYLFGASPAICGSFLKGQKTSLEFEKTAGGTLYLPYATSLRMSDLGYTNKEQASLNISYDSLHDYLQGIREAICLPSAKFAEIGVKVDGEYRQLNANVLQIENEFYAPIRAKRVTRKGEKPSEALARAGVEYIEVRALDVNPFSPVGVEASQLRFLDVFLLYCLLSDSPKSDAVCESEITSNLRAVIHEGRKPGLALSRQGEPVTLKAWLLELFDEFDKLASLLDIDGSDYAEALAQWRMAVEDPALTLSGRVHAAVVEQGMNHGDFVMGLAAKYQDFFLSYPLSPGVEAGFQAEAASSLAAQAEIEASDEESFDEYLKGYFKGVPCALS
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: NCAP_HANTV
Sequence: MATMEELQREINAHEGQLVIARQKVRDAEKQYEKDPDELNKRTLTDREGVAVSIQAKIDELKRQLADRIATGKNLGKEQDPTGVEPGDHLKERSMLSYGNVLDLNHLDIDEPTGQTADWLSIIVYLTSFVVPILLKALYMLTTRGRQTTKDNKGTRIRFKDDSSFEDVNGIRKPKHLYVSLPNAQSSMKAEEITPGRYRTAVCGLYPAQIKARQMISPVMSVIGFLALAKDWSDRIEQWLIEPCKLLPDTAAVSLLGGPATNRDYLRQRQVALGNMETKESKAIRQHAEAAGCSMIEDIESPSSIWVFAGAPDRCPPTCLFIAGIAELGAFFSILQDMRNTIMASKTVGTSEEKLRKKSSFYQSYLRRTQSMGIQLGQRIIVLFMVAWGKEAVDNFHLGDDMDPELRTLAQSLIDVKVKEISNQEPLKL
What is the function of this protein?
Encapsidates the genome protecting it from nucleases (PubMed:26923588).  The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for transcription and replication (Probable).  The nucleocapsid has a left-handed helical structure (PubMed:30638449).  As a trimer, specifically binds and acts as a chaperone to unwind the panhandle structure formed by the viral RNA (vRNA) termini (By similarity).  Involved in the transcription and replication initiation of vRNA by mediating primer annealing (By similarity).  Plays a role in cap snatching by sequestering capped RNAs in P bodies for use by the viral RdRp during transcription initiation (By similarity).  Substitutes for the cellular cap-binding complex (eIF4F) to preferentially facilitate the translation of capped mRNAs (By similarity).  Initiates the translation by specifically binding to the cap and 40S ribosomal subunit (By similarity).  Prevents the viral glycoprotein N (Gn) from autophagy-dependent breakdown maybe by blocking autophagosome formation (PubMed:31091447).  Inhibits host EIF2AK2/PKR dimerization to prevent PKR-induced translational shutdown in cells and thus the activation of the antiviral state (By similarity).  Also displays sequence-unspecific DNA endonuclease activity (By similarity).  Suppresses apoptosis probably through the inhibition of nuclear import of NF-kappa-B (PubMed:20227103).
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the hantavirus nucleocapsid protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm, host perinuclear region. Host Golgi apparatus, host cis-Golgi network. Note=Internal protein of virus particle.
Protein: CYB_GEOLU
Sequence: MAIMRKSHPLMKIVNHAFIDLPTPPNISGWWNFGSLLGLCLVLQILTGLFLAMHYTSDTLTAFSSVTHICRDVNYGWLIRYMHANGASLFFISLYIHIGRGIYYGSYLYTETWNIGILLLLLTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGQDLVEWIWGGFSVDKATLTRFFAFHFILPLIITALAMVHLLFLHETGSNNPLGIPSDCGKVPFHPYYTTKDFLGVIMLLMQFLTLVLFFSDKLGDPDNYTPANPLNTPPHIKPEWYFLFAYAISRSIPNKLGGVVALLMSILVLALLPYLHTSKQRSLSFRPLSQTLFWVLVADLLLLTWIGGQPVEPPFIIIGQVASILYFLILLLLMPMAGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RIP2_PHYDI
Sequence: VSTITFDVGSATISKYTTFLESLRNQAKDPSLKCYGIPMLPNTNPNPKYLLVELNAKLSSGEVKSITLMLRRHNLYVMGYSDPYDNKCRYHIFKDISSTTERKDVETTLCPNASSRVSKNISYDSSYPALENKAGRSRSQVQLGIQILNSDIGKISGVKSFTDKTEAEFLLVAIQMVSEATRFKYIENQVKTNFNRAFYPNAKVLNLEETWGKISMAIHGAKNGAFSKPLELQNADGSKWIVLRVDEIKPDVALLKYVSGSCQAT
What is the function of this protein?
Inhibits protein synthesis in animal cells.  Useful as immunotoxin for pharmacological applications.
What are the official names of this protein?
Protein synthesis inhibitor PD-S2, Ribosome-inactivating protein PD-S2, rRNA N-glycosidase.
What is the protein family that this protein belongs to?
Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.
Protein: YDFZ_ECOL6
Sequence: MTTYDRNRNAITTGSRVMVSGTGHTGKILSIDTEGLTAEQIRRGKTVVVEGCEEKLAPLDLIRLGMN
What are the official names of this protein?
Putative selenoprotein YdfZ.
Protein: HIS7_SYNFM
Sequence: MAGRRQGTVERITSETKIMADLTVDGEGKAELRTGVPFLDHMLSLFSVHGFFDLKLQAEGDLDVDAHHTVEDIGICLGGALAKALGDRKGIRRYGHAVVPMDEACASVTLDLSNRPFLVYRVPTLAARVGRFETELVPEFFRAFCQHGGATVHVQGLYGSNTHHILEAIFKALGRALDQATRFDERRSGIPSSKGTL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PROFZ_OLEEU
Sequence: MSWQAYVDDHLMCDIEGHEGHRLTAAAIVGHDGSVWAQSATFPQFKPEEMNGIMTDFNEPGHLAPTGLHLGGTKYMVIQGEAGAVIRGKKGSGGITIKKTGQALVCGIYEEPVTPGQCNMVVERLEDYLLEQGL
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By similarity).
What are the official names of this protein?
Profilin-1, Pollen allergen Ole e 2.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: LIPA_KOMPG
Sequence: MLSTRVVRLPKVISGGNKQLARGLASLSDEKSLNEANPTDLAGLKRKAKRRPTKLADELKTGPSFADFVTGKAKDMLVDPLELARNDPNARLPSWLKTQIPKGKSFHHLKSDLKELKLSTVCEEAKCPNIGECWGGKKSEATATIMLMGDTCTRGCRFCSVKTNRNPAPPDPNEPENTAEAISRWGLGYVVLTTVDRDDLPDGGAHHLASTVTKIKEKAPQILVECLSGDFRGNLEMAKVLASSPLDVFAHNLETVEDLTPHIRDRRATYRQSLSVLRAAKEANPRLVTKTSLMLGFGETDDQILQTLHDLRNISCDVVTFGQYMRPTKRHMKVVEYVTPSKFEYWRDKALEMGFLYCASGPLVRSSYKAGEAFIENVIKKRRTNVGAIEEQQHDKENNNLLLSKEDEKTTQEKANF
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: NPT2B_RAT
Sequence: MAPWPELENAHPNPNKFIEGASGPQSSIPDKDKGTSKTNDSGTPVAKIELLPSYSALVLIEEPPEGNDPWDLPELQDNGIKWSERDSKGKILCIFQGIGKFILLLGFLYLFVCSLDVLSSAFQLVGGKMAGQFFSNNSIMSNPVAGLVIGVLVTVMVQSSSTSSSIIVSMVASSLLSVRAAIPIIMGANIGTSITNTIVALMQAGDRNEFRRAFAGATVHDFFNWLSVLVLLPLEAATHYLEKLTNLVLETFSFQNGEDAPDILKVITDPFTKLIIQLDKKVIQQIAMGDSEAQNKSLIKIWCKTISNVIEENVTVPSPDNCTSPSYCWTDGIQTWTIQNVTEKENIAKCQHIFVNFSLPDLAVGIILLTVSLLILCGCLIMIVKLLGSVLRGQVATVIKKTLNTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSAMTPLIGIGVISIERAYPLTLGSNIGTTTTAILAALASPGNTLRSSLQIALCHFFFNISGILLWYPIPFTRLPIRLAKGLGNISAKYRWFAVFYLIFFFLLTPLTVFGLSLAGWPVLVGVGVPIILLILLVLCLRMLQARCPRILPLKLRDWNFLPLWMHSLKPWDNIISLATSCFQRRCCCCCRVCCRVCCMVCGCKCCRCSKCCKNLEEEEKEQDVPVKASGGFDNTAMSKECQDEGKGQVEVLGMKALSNTTVF
What is the function of this protein?
Involved in actively transporting phosphate into cells via Na(+) cotransport.
What are the official names of this protein?
Sodium-dependent phosphate transport protein 2B, Sodium-phosphate transport protein 2B, Na(+)-dependent phosphate cotransporter 2B, Sodium/phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, NaPi-2b, Solute carrier family 34 member 2, rNaPi IIb.
What is the protein family that this protein belongs to?
Belongs to the SLC34A transporter family.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of enterocytes.
Protein: HSP90_THEPA
Sequence: MTSKDETPDQEVYAFNADISQLLSLIINAFYSNKEIFLRELISNASDALEKIRYEAIKDPKQIEDQPDYYIRLYADKNNNTLTIEDSGIGMTKADLVNNLGTIAKSGTRAFMEALQAGSDMSMIGQFGVGFYSAYLVADKVTVVSKNNADDQYVWESTASGHFTVKKDDSHEPLKRGTRLILHLKEDQTEYLEERRLKELVKKHSEFISFPISLSVEKTQETEVTDDEAELDEDKKPEEEKPKDDKVEDVTDEKVTDVTDEEEKKEEKKKKKRKVTNVTREWEMLNKQKPIWMRLPSEVTNEEYAAFYKNLTNDWEDHLAVKHFSVEGQLEFKALLFVPRRAPFDMFESRKKKNNIKLYVRRVFIMDDCEELIPEWLSFVKGVVDSEDLPLNISRETLQQNKILKVIRKNLVKKCLELFNELTEKKEDFKKFYEQFSKNLKLGIHEDNANRSKIAELLRFETTKSGDELVSLKEYVDRMKSDQKYVYYITGESKQSVASSPFLETLRARDYEVLYMTDPIDEYAVQQIKEFEGKKLKCCTKEGLDLDEGEDEKKSFEALKEEMEPLCKHIKEVLHDKVEKVVCGTRFTDSPCALVTSEFGWSANMERIMKAQALRDSSITSYMLSKKIMEINPRHSIMKELKTRAANDKTDKTVKDLVWLLYDTALLTSGFNLDEPTQFGNRIYRMIKLGLSLDDEEHVEEDSSMPPLDEPVVDSKMEEVD
What is the function of this protein?
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction.  Undergoes a functional cycle that is linked to its ATPase activity.  This cycle probably induces conformational changes in the client proteins, thereby causing their activation.  Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
What are the official names of this protein?
Heat shock protein 90, HSP90.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS6_RICFE
Sequence: MSFYESVFIIRQDVSLNDIDKIVDDFAKIIKDNNGTIVKKEYWGLRTLAYKIGNNKKGHYYFLGLDITGNVKEELERKMKLNENIIRFLTIKADSISSEPSQILKNQSTENTPVIDVTINN
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: LPXA_BRUSI
Sequence: MKETFIHPTALVEPGVELGQGVSVGPFCHVQSGAIIGNDCELMSHVVITGATTLGAGTKVYPHAILGCDPQNNKHKGGPTRLNVGVNCIIREGVTMHKGSDNARGYTSIGDNCSFLAYAHVAHDCDIGDYVTFSNNVMIGGHTSIGHHAILGGGAAVHQFVRVGHHAFIGGLAAVVSDLIPYGMAIGVHAHLGGLNIIGMKRSGMERKEIHNLRHAVRMLFDRTKPIRQRAQDVLAAIPDSPTVSDMISFINVDTKRAYCTPPLDAAHGGAGHDSDED
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FUB11_FUSO4
Sequence: MAIDPQPSSPSLSSETIANDTIGNDNNVNEPSVEPKTQGNQHTVPPRLSRIYSQAHHISQSFIDQNYPGEGTTQAPYRINFLPDDTQNAQLLPRWKKWAFVLLQSLACLATTFASSAYSGGIKQVIRAFGISQEVATLGISLYVLGFTFGPLIWAPLSELYGRKKVFFFTFMVATAFSAGAAGAGSIASLLVLRFLTGSIGSAPLSNAPALIADMFDKSERGLAMCMFSGAPFLGPAIGPIAGGFLGEAAGWRWLHGLMAAFTGVTWIACTVFIPETYAPYILRKRAQHMSKLTGKVYISTLDADKPPSSAAHQLKNALTRPWLLLFKEPIVFITSIYISIIYGTMYMCFAAFPIVFQKGRGWSQGIGGLAFTGIVIGVVLCIISFAFEDKRYARAARKRGAPMEPEDRLPPAIMGSLLIPIGLFWFAWTTFPSVHWIVPIIGTVFFAWGLVLVFMALLNYLIDSYVIFAASIMAANSALRSLFGAAFPLFTRQMYDGLGVQWASSIPAFLALACVPFPFLFYKYGRQIRMKCEYAAEAANVLQKMRSLHVTVTEDDAMNEAEEMWRARTHNSHASAAHSHGHRRSLSYTRSV
What is the function of this protein?
Efflux pump involved in export of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:25372119).  Constitutes a self-protecting mechanism of the fungus against critical levels of FSA within the cell (By similarity).
What are the official names of this protein?
Efflux pump FUB11, Fusaric acid biosynthesis protein 11.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DEF1_AESHI
Sequence: LCNERPSQTWSGNCGNTAHCDKQCQDWEKASHGACHKRENHWKCFCYFNC
What is the function of this protein?
Possesses antimicrobial activity sensitive to inorganic cations.  Binds specifically to the fungal plasma membrane.  Has no inhibitory effect on insect gut alpha-amylase.
What are the official names of this protein?
Defensin-like protein 1, Cysteine-rich antimicrobial protein 1, Defensin AMP1, AhAMP1.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: PTSS2_HUMAN
Sequence: MRRGERRDAGGPRPESPVPAGRASLEEPPDGPSAGQATGPGEGRRSTESEVYDDGTNTFFWRAHTLTVLFILTCTLGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRPHPAYWRFWLCVSVVYELFLIFILFQTVQDGRQFLKYVDPKLGVPLPERDYGGNCLIYDPDNETDPFHNIWDKLDGFVPAHFLGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSECWWDHWIMDVLVCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSWVRFEWKPASSLRRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGVAMREIYDFMDDPKPHKKLGPQAWLVAAITATELLIVVKYDPHTLTLSLPFYISQCWTLGSVLALTWTVWRFFLRDITLRYKETRWQKWQNKDDQGSTVGNGDQHPLGLDEDLLGPGVAEGEGAPTPN
What is the function of this protein?
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:19014349).  Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:19014349).  Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity).  Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity).
What are the official names of this protein?
Phosphatidylserine synthase 2, PSS-2, PtdSer synthase 2, Serine-exchange enzyme II.
What is the protein family that this protein belongs to?
Belongs to the phosphatidyl serine synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria-associated membrane (MAM).
Protein: TRPE_BUCAI
Sequence: MFLIEKRRKLIQKKANYHSDPTTVFNHLCGSRPATLLLETAEVNKKNNLESIMIVDSAIRVSAVKNSVKITALSENGAEILSILKENPHKKIKFFEKNKSINLIFPSLDNNLDEDKKIFSLSVFDSFRFIMKSVNNTKRTSKAMFFGGLFSYDLISNFESLPNVKKKQKCPDFCFYLAETLLVVDHQKKTCLIQSSLFGRNVDEKNRIKKRTEEIEKKLEEKLTSIPKNKTTVPVQLTSNISDFQYSSTIKKLQKLIQKGEIFQVVPSRKFFLPCDNSLSAYQELKKSNPSPYMFFMQDEDFILFGASPESSLKYDEKNRQIELYPIAGTRPRGRKKDGTLDLDLDSRIELEMRTNHKELAEHLMLVDLARNDLARICEPGSRYVSDLVKVDKYSHVMHLVSKVVGQLKYGLDALHAYSSCMNMGTLTGAPKVRAMQLIAEYEGEGRGSYGGAIGYFTDLGNLDTCITIRSAYVESGVATIQAGAGVVFNSIPEDEVKESLNKAQAVINAIKKAHFTMGSS
What is the function of this protein?
Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan.  In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate.  In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity).
What are the official names of this protein?
Anthranilate synthase component 1, AS, ASI.
What is the protein family that this protein belongs to?
Belongs to the anthranilate synthase component I family.
Protein: UP01_GINBI
Sequence: GLSLSFAPK
What are the official names of this protein?
Unknown protein 1.
Protein: YEGS_SHIB3
Sequence: MAEFPASLLILNGKSTDNLPLREAIMLLREEGMTIHVRVTWEKGDAARFVEEARKLGVATVIAGGGDGTINEVSTALIQCEGDDIPALGILPLGTANDFATSVGIPEALDKALKLAIAGNAIAIDMAQVNKQTCFINMATGGFGTRITTETPEKLKAALGGVSYIIHGLMRMDTLQPDRCEIRGENFHWQGDALVIGIGNGRQAGGGQQLCPNALINDGLLQLRIFTGDEILPALVSTLKSDEDNPNIIEGASSWFDIQAPHEITFNLDGEPLSGQNFHIEILPAALRCRLPPDCPLLR
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALT11_ALTAL
Sequence: MSSPELPSQMGVPNGHTKLQEVTPDTPLDEVFQKWEEDGGVIIKGILAPAQVTQLREELQPLLDTFQRGSTTDIEPLKRFHGSQTKRAGGLTNCSAIFRDYLLDNDFLHAIAARCFGSGGRPGVHAYWISSANTINVGPGQPAQVLHRDLGNYPHYHLLGPDGPESQATFLIATTDFTDANGATRIIPGSQKWPFNQTWNPSQSIPSEMHAGDCLLFGGKVVHGTGANTTNAERGCVAFTFCANHLTPEEAHPHIVDINIVRKLSERAQRSLGFRSQYPRGAPGLWMEGYNEVATRLGLDSK
What is the function of this protein?
Dioxygenase; part of the gene cluster that mediates the biosynthesis of the host-selective toxins (HSTs) AAL-toxins, sphinganine-analog mycotoxins responsible for Alternaria stem canker on tomato by the tomato pathotype (PubMed:18435561, PubMed:19749175, PubMed:19449880).  The biosynthesis starts with the polyketide synthase ALT1-catalyzed C-16 carbon chain assembly from one starter acetyl-CoA unit with malonyl-CoA extender units (PubMed:18435561, PubMed:19449880).  ALT1 also selectively transfers methyl groups at the first and the third cycle of chain elongation for AAL toxin (PubMed:19449880).  The C-16 polyketide chain is released from the enzyme by a nucleophilic attack of a carbanion, which is derived from R-carbon of glycin by decarboxylation, on the carbonyl carbon of polyketide acyl chain (Probable).  This step is probably catalyzed by a pyridoxal 5'-phosphate-dependent aminoacyl transferase ALT4 (Probable).  The respective functions of the other enzymes encoded by the cluster have still to be elucidated (Probable).  The sphingosine N-acyltransferase-like protein ALT7 seems not to act as a resistance/self-tolerance factor against the toxin in the toxin biosynthetic gene cluster, contrary to what is expected (Ref. 5).
What are the official names of this protein?
Dioxygenase ALT11, AAL-toxin biosynthesis cluster protein 11.
What is the protein family that this protein belongs to?
Belongs to the PhyH family.