PharMolix/UniProtQA huggingface dataset:
Protein: BIOD_CLOK5
Sequence: MAKGIFIVGTDTDIGKTVVTAGLMHVLRSRGYNAVYFKAALSGALEIDNKLIPSDTKLVSDVSKLEEPYENITPYVYRTGVSPHLAARLENNPMDLDIVKEKYVYLKEKYDFIIAEGSGGIVCPLIDDGRGVYTIGNLIKDLNMSVIIVASAGLGTINHTVLTAKYIENLGIKIEGIIINKYEKDLFYDDNIGMIEKITKLPIVAKLKNIKDMNDNEIEAIRIHSEKAFSAENIIKHMEQL
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1380_YERPE
Sequence: MSAYSRPVLLLLCGLLLFTISIAVLNTLVPLWLSHQQLPTWQVGMVSSSYFTGNLVGTLIAGRFIQQLGFNRSYHCSCILFALATCGLMLTVDFWSWLGWRFLAGIACALIWVIVESALLRSGTLTNRGQLLAAYMMVYYLGTVIGQLLLGIVSTQLLSVIPWVGALVITAMLPLLFAQFSHQSRHESPPIAVWPMLKRRSARLGINGCIISGVLLGSLYGLLPLYLSHKGMSDASVGGWMALLVSSGIIGQWPMGRMADRYGRLLVLRIQVFVVILGSVAILGNYAMAPALFILGCAGFTLYPVAMAWACEKASADELVAMNQALLMSYTLGSLAGPTMTSLLMQRYSDNLLFIMIAGVAFVYLMMLLRKPDHQQTPYAAV
What are the official names of this protein?
Uncharacterized MFS-type transporter YPO1380/y2792.1/YP_1213.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FOXE4_XENLA
Sequence: MDSPDSVRVKCESKGSCSPEEGLNNGLPEEHNQASGGRRRKRPVQRGKPPYSYIALIAMAIANSPERKLTLGGIYKFIMERFPFYRENSKKWQNSIRHNLTLNDCFVKIPREPGHPGKGNYWTLDPAAEDMFDNGSFLRRRKRFKRTDITTYPGYMQNSSAFTPTPTGRASYPNSIYSSVGSGYNPQIHQTHHPAVVHQYYQSPGEAGQGQHRMFSIDSLINQQSLMQPSPGAELTHHSLGLNGNLGNMTNSCSVGDLSCFQTQSISPTGVGSLLNRSSNAVSSNLTYSYSSSPPHLPVPPASYSPNNSQLYGSTSRLAMRSGPCVDHTDQLLSLPGTQINGVCQYNNSSYMRQTHFASGLERYM
What is the function of this protein?
Probable transcription factor.  Mediates lens formation in the embryo by promoting the proliferation of the specified lens ectoderm and suppressing its terminal differentiation.
What are the official names of this protein?
Forkhead box protein E4, FoxE4, Xlens1.
What are the subcellular locations of this protein?
Nucleus.
Protein: PCID2_CAEBR
Sequence: MSFVRNISDYFNKIDNLCYNQSWESGDKIAKYLSLNDDHSKEAYLHISEYGSTSRRCRVSEDEIIDEIVCLHLHVLHSVHVAKDLISSQSTQIRIIQLFNKEILQKRKDENWFLPIFYRLCTDLRWLSKGAESCASGDDEGDSNANSFFESAAKAITECYRTCVSDVHAEEGKTKKVAMLNMTNQLFQIYFQINKLNLLKPLIRAIDNCGPLYNKFLMADKVAYNYFLGRKALFDGDLILAEKGLVYAFRNCPTESVSNKRKILVYLIPVKMFLGHMPTASLLHRYRLDEFQEVVAAVKDGHLGRVDNALLTNGEFFIKCGIYLVLEKLRTITYRNLFKKVSQMVGKVQIPLDAFQAALRFVGVTDVDMDELECIIANLIAEKKVKGYLAHQHQKLVISKTNAFPTLSSVSSN
What are the official names of this protein?
PCI domain-containing protein 2 homolog, CSN12-like protein.
What is the protein family that this protein belongs to?
Belongs to the CSN12 family.
Protein: PROA_CHLPB
Sequence: MKETIYKQLEKVREASRKLCTLSDSDINSLLNDLANRIPGNSQTILEANQKDLDRMDPNDPKYDRLLLSTSRLESIASDIRNVAELPTPVGRILEKRTLPNGLALKKTTVPLGVVGIIYESRPNVTFDVFALCLKSGNATVLKGGSDAMYSNMAIVDLIREVLVRNNVNPDTLYLLPSDREAAGIMLNAVGYIDVIIPRGSQQLIDFARKSSSVPVIETGAGIVHTYFDLSGDLQMGKEIVFNAKTRRPSVCNALDTLLIHRERLDDLASIAEPLAEKKVIIFADKDAYPALLSRYPSELLQKAEEKHFGTEFLSLKMSVKTVDSLEDALKHIARFSSMHSEAVIASDAVVKDEFLKRVDAAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALQELTSYKWVIEGDGQTRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLC6A_MOUSE
Sequence: MVQERQSQGKGVCWTLRLWSAAVISMLLLSTCFIASCVVTYQFIMDQPSRRLYELHTYHSSLTCFSEGTMVSEKMWGCCPNHWKSFGSSCYLISTKENFWSTSEQNCVQMGAHLVVINTEAEQNFITQQLNESLSYFLGLSDPQGNGKWQWIDDTPFSQNVRFWHPHEPNLPEERCVSIVYWNPSKWGWNDVFCDSKHNSICEMKKIYL
What is the function of this protein?
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C. albicans hypheas (PubMed:17050534, PubMed:19703985, PubMed:20493731).  Binding of C. albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:17050534, PubMed:19703985, PubMed:20493731, PubMed:32358020).  Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (PubMed:19124755).  Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (PubMed:21059925).
What are the official names of this protein?
C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dendritic cell-associated C-type lectin 2, DC-associated C-type lectin 2, Dectin-2.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: ALKB5_XENLA
Sequence: MSATYTDLREKLQSLNRDSPKEVRKRKQPASDTEEEDEAGSEPEAEEEEARKVRSGIRQMRLFSPDECAAIESKIDEVVSRADKGLYQEHTVDRAPLRNKYFFGEGYTYGAQLQRRGPGQERLYPKGEVDEIPGWVHELVIRRLVERRIIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFQFKPIRVSEPVFFLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVVILRKTRTEAPRLEMKSLSSSYQPERLQGSNRQHILKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPKQRRRSHFSSENYWRRSHDHVDTYTETGEDEGSPVRKVKMRRH
What is the function of this protein?
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes.  Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity).  Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).  Demethylation of m6A mRNA affects mRNA processing and export (By similarity).
What are the official names of this protein?
RNA demethylase ALKBH5, Alkylated DNA repair protein alkB homolog 5, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5.
What is the protein family that this protein belongs to?
Belongs to the alkB family.
What are the subcellular locations of this protein?
Nucleus speckle.
Protein: ISPE_VIBC1
Sequence: MIDLSTRWPSPAKLNLFLYINGRTENGYHELQTLFQFVDHGDELTIQANDSGEITISPEIEGVPLKDNLIWKAATALQRFANCSYGAHIDLHKILPMGGGIGGGSSNAATALVALNYLWQTNLSDDELAEIGLALGADVPVFVRGFSAFAEGVGEKLSPAHPDEKWYLVVRPNVSIATADIFGHPDLTRNTPKRDLETLLNTPSVNDCEKIVRMLYPEVDKQLSWLLQYAPSRLTGTGSCVFAEFSSKSEAETILAQLSDKVSAFVAQGRNISPLKETLAEYQSASHRPI
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PRAC1_HUMAN
Sequence: MLCAHFSDQGPAHLTTSKSAFLSNKKTSTLKHLLGETRSDGSACNSGISGGRGRKIP
What are the official names of this protein?
Small nuclear protein PRAC1, Prostate cancer susceptibility candidate protein 1, Prostate, rectum and colon expressed gene protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: PDXT_ARCFU
Sequence: MKVAVVGVQGDVEEHVLATKRALKRLGIDGEVVATRRRGVVSRSDAVILPGGESTTISKLIFSDGIADEILQLAEEGKPVMGTCAGLILLSKYGDEQVEKTNTKLLGLLDAKVKRNAFGRQRESFQVPLDVKYVGKFDAVFIRAPAITEVGKDVEVLATFENLIVAARQKNVLGLAFHPELTDDTRIHEFFLKLGETS
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: RK16_PINKO
Sequence: MLSPKRTKFRKQHRGRMKGVSYRGNRICFGRFALQALEPAWITSGQIEAGRRTITRYARRGGKIWVRIFPDKPITMRPAETRMGSGKGSPEYWVSVIKPGRILYEMGGVSETVARAAARIAAYKMPIRTQFVTT
What are the official names of this protein?
50S ribosomal protein L16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SECB_SHELP
Sequence: MAEAVNNEQQGPQFNIQRVYTKDISFETPNSPAVFQKEWNPEVKLDLDTRSAKLADDVYEVVLSLTVTAKNGEETAFLCEVQQAGIFAISGLTDQQLAHSLGAYCPNVLFPYAREAVGSLVARGTFPQLNLAPVNFDALFAQYVQQRQAQAEAAGEAAEANA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHB2_HUMAN
Sequence: MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit beta-2.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: HPRL_HALBP
Sequence: MDQLRQSLLEAPIIEKGEYEYFVHPISDGVPMLEPGLLREIVIKIIRKADLEDVDKIVTPAAMGIHISTAVSLMTDIPLVVIRKREYGLDGEISLSQQTGYSENDMFINDVSEDDRVLVIDDVLSTGGTMCAVLDALKSTGAEVVDTVAVIKKAGPNELDDTDHHVKTLINVTVEDGEVVIVDENGDD
What is the function of this protein?
May catalyze a purine salvage reaction, the substrate is unknown.
What are the official names of this protein?
HGPRTase-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
Protein: KRE1_CANAW
Sequence: MNVNSVIYYILFLFASTILAADKTSSSVSPTLVWVTGTDANGKLATTQSTYYQSFMSTYTTAETPSSGSIGLGSISGTVGEIRTYSMTTISQGNGGLSKFNQNGLEMKNLSFVKLIGVSFIAFISFILLI
What is the function of this protein?
Involved in cell wall 1,6-beta-glucan assembly possibly by the addition of linear side chains of 1,6-linked Glc units to a highly branched 1,6- and 1,3-linked glucan backbone.
What are the official names of this protein?
Protein KRE1.
What is the protein family that this protein belongs to?
Belongs to the KRE1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Secreted, cell wall.
Protein: ADSL5_ARATH
Sequence: MCDPIREDGSNKRGAVSKEKRPYIHREWSWADIIRALTVINVHFLCLLAPFNYKWEALRFGFVLYALTSLSITFSYHRNLAHRSFKLPKWLEYPLAYFAVFALQGDPLDWVSIHRFHHQFTDSDRDPHSPIEGFWFSHVWWICDTRYIKYKCGGRNNVMDLKQQWFYWFLRMTIGFHVLMFWTVLYLYGGLPYLTCGGGVGGVIGYHVTWLVNSACHIWGSRSWKTKDTSRNVWWLSLFTMGESWHNNHHAFESSARQGLEWWQIDITWYLIRLFEVLGLATDVKLPSEIQKQKLALTR
What are the official names of this protein?
Delta-9 desaturase-like 5 protein.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ARGB_EHRCJ
Sequence: MKLHNVLKNNNNNKEDVGPSIEQFGGNAEWFNTTKVLSECLPYIQQFSGETFVIKYGGAAMTDRKLAESFAHDIVLLKQLGINPIVVHGGGNKINSFLEKINKKSTFINGLRVTDAETLEVVEMVLCGLVNKDITQLINKAGGNAIGLCGKDANLIEAKKVCYTYKENQSNNVEKILDMGFVGEPHEVNTDLLFFIEESDFIPVIAPVCSGENNITYNVNADLVAGALANALAAAKLIILTNVSGVTDANGNLLSEISVSDAENLIEQGVANSGMIPKLQTCIKVVKEGYGSAHIIDGRIPHVLLLELFTVHGTGTMVLGNDI
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDI_YERPB
Sequence: MNPLVYFSSSSENSHRFVEKLQLPAIRIPIAGAREKLRVEQPYILLVPSYGGGSPVGAVPIQVIRFLNDVHNRSLIRGVIAAGNTNFGDAYCLAGDIISHKCQVPYLYRFELLGTAEDVANVRKGVTEFWQRQN
What is the function of this protein?
Probably involved in ribonucleotide reductase function.
What are the official names of this protein?
Protein NrdI.
What is the protein family that this protein belongs to?
Belongs to the NrdI family.
Protein: NQRD_PASMU
Sequence: MADTKKLKGLLLSPVMDNNPIALQILGICSALAVTTKLETAIVMTFAVIFVTAFSNLFISLIRNYIPNSVRIIVQMAIIASLVILVDQILRAYAYGLSKQLSVFVGLIITNCIVMGRAEAFAMKSQPLESFVDGIGNGLGYGAILVSVAFIRELIGSGKLFGMTVFQTIQDGGWYQTNGLFLLAPSAFFIIGFIIWGIRTLKPNQVEK
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RISB_HAES1
Sequence: MKVLEGIVTAPNAKIAVVIARFNSFINESLLEGALDALKRIGQVKDENITLVRVPGAYELPLIARRLADSKKYDAIVALGTVIRGGTAHFEYVAGEASSGLGQVAMQAEIPVAFGVLTTENIEQAIERAGTKAGNKGAEAALVALEMVNLLAQIDKA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: SAU51_ARATH
Sequence: MAMKKANKLTQTAMIKQILKRCSSLGKKQSNVYGEDENGSPLNVPKGHFVVYVGENRVRYVVPISFLTRPEFQLLLQQAEEEFGFDHDMGLTIPCEEVVFRSLTSMLR
What is the function of this protein?
Provide a mechanistic link between auxin and plasma membrane H(+)-ATPases (PM H(+)-ATPases, e. g.  AHA1 and AHA2), and triggers PM H(+)-ATPases activity by promoting phosphorylation of their C-terminal autoinhibitory domain as a result of PP2C-D subfamily of type 2C phosphatases inhibition, thus leading to the acidification of the apoplast and the facilitation of solutes and water uptake to drive cell expansion (By similarity).  Triggers plant growth probably by promoting cell elongation (By similarity).  Regulates branch angles and bending (By similarity).
What are the official names of this protein?
Protein SMALL AUXIN UP-REGULATED RNA 51.
What is the protein family that this protein belongs to?
Belongs to the ARG7 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y495_MYCTU
Sequence: MWRPAQGARWHVPAVLGYGGIPRRASWSNVESVANSRRRPVHPGQEVELDFAREWVEFYDPDNPEHLIAADLTWLLSRWACVFGTPACQGTVAGRPNDGCCSHGAFLSDDDDRTRLADAVHKLTDDDWQFRAKGLRRKGYLELDEHDGQPQHRTRKHKGACIFLNRPGFAGGAGCALHSKALKLGVPPLTMKPDVCWQLPIRRSQEWVTRPDGTEILKTTLTEYDRRGWGSGGADLHWYCTGDPAAHVGTKQVWQSLADELTELLGEKAYGELAAMCKRRSQLGLIAVHPATRAAQ
What are the official names of this protein?
Uncharacterized protein Rv0495c.
What is the protein family that this protein belongs to?
To M.leprae ML2435 and S.coelicolor SCO3349.
Protein: MTNB_AJECN
Sequence: MAAIKDENNDHLVQSDNPEHPSNLIPALCRNFYSHGWVTGTGGGASIKRDNHIFIAPSGVQKELIQPHDIFVLQYPTPKYPPSARQYIRKPLELKPSACTPLFLAAFDRGAGCCIHTHSQWAVLVTLLVEREKGPEGCFEISNIEQIKGIPRGKGKGMLGFFDTLKIPIIENTAFEEDLTSSLEEAMEKYPDTYAVLVRRHGIYVWGDDVAKAKTQCESLDYLFQLAVEMHKLGLPWVKS
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_PSET1
Sequence: MRAEIMAAMKVQPVIDVNAEISRRVNFIKARLIAAHATSLVLGISGGVDSSVCGRLCQLAVNELNQEQSTTDYKFVAVRLPYGVQADENEAQLAVDFIQPSSRMTVNIKPATDALHEQTMAAIVGNGESLPEQEKIDFIKGNVKARQRMIAQYEIAAFCQGLVVGTDHSAENITGFYTKFGDGACDLAPLFGLSKRQVRALGSTLGASSVLVNKAPTADLESDRPGLTDEEALGLSYEQIDDFLEGKPVTQQVEQTLSAIYQRTQHKRQPVPTIYDEL
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: KHSE_CUPTR
Sequence: MAVFTTVSQDEIARWLLDFDLGEVRELRGIASGIENSNFFLTMEHEGQTRQYVLTIFERLSFTQLPYYLHLMAHLAERGIRVPAPIPARDGEILRPLKGKPATIVTRLPGASQLAPDAQHCAEVGDMLARMHLAGADYPRRQPNLRSLPWWQQTEREILPFLDAGQRALLQREIAHQAAFFASAAYASLGEGPCHCDLFRDNALFEEDASGRHRLGGFFDFYFAGNDKWLFDVAVTVNDWCIDLATGELDAERAQALLRAYHAVRPLTETEAAHWQDMLRAGALRFWVSRLWDFYLPREADMLQPHDPTHFERILRRRLDAQPANPESAPLPWI
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: PRIO_MOSCH
Sequence: MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGAGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGTHNQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: YKEE_SCHPO
Sequence: MFRRNTLTPGKGRNSLDMFSVNDFMTWIDGMKKTSDENGCSPFTLKPIKSTSDRKRRRHSRMSIVNVWNQSPTSYRDQLLHFNHESDVSIDDTSEVAGEETFGQIERFEYLLSSDGDGDGDVEIENPEVDDYQVSEHDFGLEDDFNGDGCQQMIEIESDEAISEEEEDLSNENKSESQLGESFSFNQDNTFVNYASPASITEEFVEPKDSQFNHDVNLMQGSAPGYSTVEPEDNFASEIQTNAPEVHLNYENSDYTEDHIDLLDHHFCDLSEISKFNHQHSGKPDHPSLVSNASLAPFIVEGNGIKNGLLHYNMETAETDESYTDLDDTFARLKNLSQRHTNHSTDHHDDTVDSHLLHSFVSAENANEPTNDVDDNSLQEQVADASQFVSFLETTKTVATSNLRSTKRKLSEILENGQSGDCSLTDTNVDFDISEKQASGNSRSMIPLRKKR
What are the official names of this protein?
Uncharacterized protein C1805.14.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: BIOD_CLOP1
Sequence: MEKGVYIIGTSTDIGKTFISGLILKKLREEGRNAGYYKAVLSGAIKDKKGLIPLDCEEVMEISGLKESYENMVSYILENPYSPHLASEVEEVSISMEKIKKDYKSVRDKYDFILCEGSGGIVCPISFSEKKLMLEDIIKEFNLPIILVSNSGLGAINHTVLTVSYLRNLGLKVKGIILNKFNKSDIIHRDNKKIIKELTGVNNISTVPKIEDIEKYDLNELNEVLYGI
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL4_CLOP1
Sequence: MPKVGLFNKEGQQVGDIQLNEQVFGVEVNKYALHQVVVAQLANKRQGTQSAKTRSEVRGGGIKPWRQKGTGRARQGSIRAPQWIKGGVVFAPKPRDYRMSIPKSMRKVAMTSALTSKVADMVVLEDLTFEAPKTKEAVKMLNAFEAKKTLIITAEVNENVYKSARNIEGVTVMPVNNINVYDLLNCKTLMITKEAVNKIEEVYA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RL23_STAA9
Sequence: MEARDILKRPVITEKSSEAMAEDKYTFDVDTRVNKTQVKMAVEEIFNVKVASVNIMNYKPKKKRMGRYQGYTNKRRKAIVTLKEGSIDLFN
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: DNAJ1_MYCLE
Sequence: MAQREWVEKDFYKELGVSSDASPEEIKRAYRKLARYLHPDANPDNSAGERFKVVSEAHNVLSDPVKRKEYDETRRLFAGGWLGGRRFDSSFGDFGMGGDGAEFNLNDLFDAASRTGGTNIGDLFGGLFGRGASVRPSRPRRGNDLETEADLDFVEAAKGVAMPLRLTSPAPCTNCHGSGARPGISPKVCSTCNGSGVINRNQGAFGFSEPCTECRGSGSIIEHPCEECKGTGVTTRTRTINVRIPSGVEDGQRIRLAGQGEAGLRGAPSGDLYVTVHVRPDKIFGRNGDDLTVTIPVSFTELALGSTLSVPTLDGTVGVRVPKGTSDGRILRVRGRGVPKRSGGHGDLLVTVKVAVPLNLEGAAQKALEAYAAAERSSGFNPRAGWGR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ 1.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.