PharMolix/UniProtQA huggingface dataset:
Protein: EX7L_THEP3
Sequence: MQLKALEVREITDYIKKMMDNDIILRNVRVKGEISNLKYHSTGIYFTLKDEIASLKCVMFNEYGKLLNFTLQDGMSVIVTGRISVYERNGTYQLYAQSIQSDGIGALYFAFNKLKEKLQKEGLFDSDKKKPIPKHPKKIAVVTSPTGAVIRDIITISRRRNPTVDILVVPVLVQGSSAADEICNALRILNKREDIDVIILARGGGSLEEIWPFNEEKVARCIYASRIPVVSAVGHETDFTISDFVADLRAPTPSAAAEIVVPDIKVYQRELFLLKTKLLTLMTAELNRKKKEFEGLKRALYLNSPTKKSEILRHKVENLTASLYNEMLSIYQHKRNDFLILAEKLNSLSPLKVLTRGYTIVLDKQEKVISSVKDIKPYDEIKILFKDGKAKAIVQEVKENE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_PYRAR
Sequence: MTLSVGGIDEAGRGPVVGPLVLAIVVGDSEALSKIGVRDSKSLSPRAREVLYGKILEMAVCVNYAVVEPYEIDLHVSRGMLNALEMKYAAKLMELCPADLYYVDSPDVKAARFGDGLSFLTGRRVVSLHKGEAVPQVAAASIVAKVVRDRLVEMLRKEVGDFGSGYPSDRKTREWLRGGRIPHECVRWSWETVGKLFK
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCM1_XENLA
Sequence: MYPECGVETKSRPCSKQLQEEVSYPEWISRSYVELMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLEPNHAYPPGLLIAFSACTTVLVAVHLFALMVSTCILPNIEAVSNVHNLNSVKESPHERMHHHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPVNSPKISSNETSAVSSGQAAAITSTAIMVPFGLVFIVFAVHFYRSLVSHKTDRQFQELNELAELAQLQDQLDHRGDPVQSPVHYA
What is the function of this protein?
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores.
What are the official names of this protein?
Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A.
What is the protein family that this protein belongs to?
Belongs to the Orai family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TNFA_RAT
Sequence: MSTESMIRDVELAEEALPKKMGGLQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPNKEEKFPNGLPLISSMAQTLTLRSSSQNSSDKPVAHVVANHQAEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLIYSQVLFKGQGCPDYVLLTHTVSRFAISYQEKVSLLSAIKSPCPKDTPEGAELKPWYEPMYLGGVFQLEKGDLLSAEVNLPKYLDITESGQVYFGVIAL
What is the function of this protein?
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
What are the official names of this protein?
Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted. SUBCELLULAR LOCATION: [C-domain 1]: Secreted. SUBCELLULAR LOCATION: [C-domain 2]: Secreted.
Protein: RL34_ACIB5
Sequence: MKRTFQPSELKRKRVHGFRARMATKAGRQVLARRRAKGRHSLTV
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: FOL1_PNECA
Sequence: MIFKSLKIFPFYQIYGFRFLKGMIFKKKIHLSKLNKNHDLIHIHSLTLKSIVGKNSWAQRLLQPVVLTLSMGINASLSGNMDDLSYSIDYATVYKEVFKLVENSKFENLLDLSDKISKVVLGDKCKGNWVKVIAETPKGHLLAETGLQIIRRKDGIREIDDQFFIKNLSLYTIIGINPEERVNKQNIIIDLILFKSSINLECKDDFIINTYNIEKLLKEIVKHVEESTFKTIEALALSIARISCISHNIEKIIVKVKKSCALAFAESAGVEIVRSRSCFSSNNYIKSENSIDNEAVYISLGSNLGNRIKFILDAIEKMSIKGIKVLKTSMLYESKPMYFKDQPAFYNAVCKVQTSLHPEQLLFELQLIEKELGRVKVIDKGPRCIDLDIVFYGRKIINSESLIIPHPRVLERSFVLKPLLDISGDLVHPVTGLSIASYFEKIVDHDIKPVLPFLYKNKSIDFSFRSYKAPTYIMAILNLTPDSFFDGGIHSYDSVLIDVEKFINAGATIIDIGGQSTRPGSYIIPLEEEIFRVIPAIKYLQKTYPDILISIDTFRSEVAEQAVKAGASLVNDISGGRYDPKMFNTVARLKVPICIMHMRGNFLNMDNLTDYGTDIIEQITIELEKLLNSAEKSGIPRWNIILDPGLGFSKTLHQNIELLRRFNELKSKNCFNGLPWLLGPSRKRFTGFITGDNMPKDRIWGTVAAVVASISGGCDIIRVHDVYEMYKISKMSDAIWKEIY
What is the function of this protein?
Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
What are the official names of this protein?
Folic acid synthesis protein fol1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DHPS family.
Protein: RL23_CLOAB
Sequence: MYTNSHDIIRKPVITEKSMAEMADKKYTFIVDPHANKVQIKKAIEEVFGVKVEKVNTSNILGKTKRVGVHVGKRADYKKAIVKLTEDSKAIEFFEGMQ
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: NPC2_MOUSE
Sequence: MRFLAATILLLALVAASQAEPLHFKDCGSKVGVIKEVNVSPCPTDPCQLHKGQSYSVNITFTSGTQSQNSTALVHGILEGIRVPFPIPEPDGCKSGINCPIQKDKVYSYLNKLPVKNEYPSIKLVVEWKLEDDKKNNLFCWEIPVQITS
What is the function of this protein?
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:12591949, PubMed:17018531, PubMed:21315718, PubMed:26296895).  Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1.  May bind and mobilize cholesterol that is associated with membranes.  NPC2 binds cholesterol with a 1:1 stoichiometry.  Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity).  The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (PubMed:21315718).
What are the official names of this protein?
NPC intracellular cholesterol transporter 2, Epididymal secretory protein E1, mE1, Niemann Pick type C2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Lysosome. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes.
Protein: RMTC_PROMI
Sequence: MKTNDNYIEEVTAKVLTSGKYSTLYPPTVRRVTERLFDRYPPKQLEKEVRKKLHQAYGAYIGGIDGKRLEKKIEKIIHEIPNPTTDEATRTEWEKEICLKILNLHTSTNERTVAYDELYQKIFEVTGVPTSITDAGCALNPFSFPFFTEAGMLGQYIGFDLDKGMIEAIEHSLRTLNAPEGIVVKQGDILSDPSGESDLLLMFKLYTLLDRQEEASGLKILQEWKYKNAVISFPIKTISGRDVGMEENYTVKFENDLVGSDLRIMQKLKLGNEMYFIVSRL
What is the function of this protein?
Specifically methylates the N(7) position of guanine 1405 in 16S rRNA.  Confers resistance to various aminoglycosides, including gentamicin and kanamycin.
What are the official names of this protein?
16S rRNA (guanine(1405)-N(7))-methyltransferase, 16S rRNA m7G1405 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Aminoglycoside resistance family.
Protein: KDPC_FLAPJ
Sequence: MKNIFSILKLTFLMVVLFAVIYPLAIYGIAQFAPNKGKGETISVNEKVVGYQKIGQKFDQSNYFWGRPSAVDYNAAGSGGSNKAASNPDYLALVQKRIDTFLIAHPYLKKLEIPADMVTASGSGLDPNISPEGALIQVKRVAEVRKLSEEKVKALVENKINKPTLAGTSTVNVLELNVALDELK
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TRMB_ANADE
Sequence: MIFSIEDDAPIVRDLLPDWRARFGEAGGRLELEIGCGHGGFALGFARAFPERALVGIEQRRKFAAELAAKGARHGLSNLLVLNGDARLLAPRLFAAGSLAAIHVHFPDPWWKRRHHRRRLVDDRMSALLLGLLAPGGVLDFRTDVERYAREAVVRLEEVGFRNAAGPGRFAEAAPDEIPSTRERRYLASGEPVWRLRLVKA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RS9_LEVBA
Sequence: MAQVQYRGTGRRKNSSARVRLVPGSGKIVMNNKAIEDYIPFASIREVVLQPFNVTETLGNYDALVTVRGGGFSGQAGATRHGIARALLEVDPDFRGPLKRAGLLTRDARMKERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RL1_PARD8
Sequence: MSKLTKNQKLALGKIEAGKAYTLKEASALVKEITTTKFDASVDVDVRLGVDPRKANQMVRGVVSLPHGTGKQVRVLALCTPDKEAEATAAGADYVGLDEYINKIKGGWTDIDVIITMPSIMGKIGALGRVLGPRGLMPNPKSGTVTNEIGNAVKEVKQGKIDFKVDKSGIVHTSVGKVSFTPEQIRDNAKEFISTLIKLKPTAAKGAYIKSIYLSSTMSAGIKIDPKSVEEN
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: HLDE_VIBC3
Sequence: MKPVLPDYSKAGVLIVGDVMLDRYWYGPTGRISPEAPVPVVKVEQSEERPGGAANVAMNIASLGGHAHIIGLTGQDEPANVLANKLTSLKVHCDFVALPDYPTITKLRVLSRGQQLIRLDFEDKFENTDAQLILSRMESALPKVRAVILSDYAKGALEHVQQFIQKAKAAGVPVFIDPKGSDFERYRGASLLTPNMSEFEAVVGKVKSEQELVEKGFALIEKFDLGALLVTRSEHGMTLLRRGLEPFHLPTQAKEVYDVTGAGDTVISVLAASVAAGKALDEACALANAAAGVVVGKLGTSTVSTIELAEAVHGSKDTDYGVISEDALIEAVKKAQARGEKVVMTNGCFDILHAGHVSYLNHAAELGDRLIVAVNTDESVKRLKGPGRPVNSTDRRMAVLAGLGAVDWVVPFSEDTPQRLIAAILPNLLVKGGDYKPEEIAGGKEVIAAGGEVKVLNFEEGCSTTEIIEAIKGGRG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: SYE_SHIFL
Sequence: MKIKTRFAPSPTGYLHVGGARTALYSWLFARNHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLSLEWDEGPYYQTKRFDRYNAVIDQMLEEGTAYKCYCSKERLEALREEQMAKGEKPRYDGRCRHSHEHHADDEPCVVRFANPQEGSVVFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKALKAPVPVYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSHGDQEIFTREEMIKYFTLNAVSKSASAFNTDKLLWLNHHYINALPPEYVATHLQWHIEQENIDTRNGPQLADLVKLLGERCKTLKEMAQSCRYFYEDFAEFDADARKKHLRPVARQPLEVVRDKLAAITDWPAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGQSPALDVTVHAIGKTRSIERINKALDFIAERENQQ
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_KOCRD
Sequence: MSGHGAPTTDATTLDASTLRVAVVAASWHTTIMDGLLDGARRALADARAGHVVQVRVPGSFELPVAASRLAGDVDAVVALGVVVRGGTPHFDYVCHAATSGLTEVSVRTGTPVGFGLLTCDTEEQGLDRAGLEGSHEDKGYEAAHAALSTALTLGY
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: MDV1_ASPCL
Sequence: MAKQRRDESPSGLSDIVEPDGLLGTGLTSRHIEAFGRKVTSTAGHLMGPTTESSNGGHYHTAMVDIHRELRRPTTQRKVFSLTQTTPTDLVRSKLSTTEIQSRAISSLPDELLANIPEDSSSYSLFEGFKATQDDHEYRKSHRRRSSKAKKLLKDGQAKEALPSAPTDLKKDRDLLSRRLDLMGVRKNMCSSEIHDIDNKIANLHNMRKIVLERLAGLEMEEAELEHELTEIDNKLEDIQEDTPGTPVAVSTPKSSEAADDSVLSEDSAMDASFMSESIYQKLPSPKSLKKRSIRKRSMPILHEHFSPGSQIKEMQAHTDMVTAIDFDYPFGTMVSAALDDTVRVWDLNTGRCMGFLEGHNASVRCLQVEDNIVATGSMDASVKLWDLSRARTVPRDNRVGRPDEEDEEDDGTDAFSILSATTLEDCYVFSLDAHVDEVTALHFRGDTLISGSADKTLRQWDLVKGRCVQTLDVLWAAAQASTIGADTQWRPSGRLPDASADFVGAVQCFDAALACGTADGMVRLWDLRSGQVHRSLVGHTGPITCLQFDEVHLVTGSQDRSIRIWDLRMGSIFDAFAYEKPITSMMFDTKRIVAAAGENVVKVYDKADSNHWDCGAGLGADEVGPAPATVERVRLKDGYLLEGRKDGIVAAWTC
What is the function of this protein?
Involved in mitochondrial fission.  Acts as an adapter protein required to form mitochondrial fission complexes.  Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
What are the official names of this protein?
Mitochondrial division protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat MDV1/CAF4 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y365_WIGBR
Sequence: MSISIKNLILDAWNFFVNQIINIIFFSTISAIISSLINYIFLPNRDELFTLANLISDFNGSINNINYLFQKMSIEQKYILFKLSLSNHLSSLVGNAFLFSNIITMINTICDKKRFFNIFNNIILSSSLIPKFLTLIFLISFLTQCGMALMLIPGIIVLIFLSFSPILITKKNISITDSIKISVNITFKNIKTVAPIIFLWLLIKLIILVISSQISINGFLSSVKIFFYLINNIITVYIIIYMYRLYLLSKIKKNKYL
What are the official names of this protein?
UPF0259 membrane protein WIGBR3650.
What is the protein family that this protein belongs to?
Belongs to the UPF0259 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FOLD2_HALMA
Sequence: MTTVIDGNEIGDQITEGVAACTDTLVSEGVTPGLATVLMSDDGASETYVSMKQRACNEIGIEGFHHQISADESAEALFSTIDELNADPAVHGILVQMPVPDHVPKRDVLERIDPMKDVDGFHPENVGRLVAGNARYKPCTPHGIQKMLAETGVVTEGKDVVVVGRSDIVGKPMANLLIQYGPGGNATTTVCHSRTDDLADKTRNADIVIAAAGVPEMIDGSMLSAGTTVIDVGINRVDADTEKGYELVGDVDFESAKEKADAITPVPGGVGPLTIAMLLYNTVKAASLQSGVDIRLP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 2.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SPRI_DROME
Sequence: MVNAVMDAIALLSSLASDLDIMLNDLRSAPSHAATATATATTTATVATATATTTANRQQQHHNHHNQQQMQSRQLHAHHWQSINNNKNNNISNKNNNNNNNNNNNINNNNNNNNHSAHPPCLIDIKLKSSRSAATKITHTTTANQLQQQQRRRVAPKPLPRPPRRTRPTGQKEVGPSEEDGDTDASDLANMTSPLSASAAATRINGLSPEVKKVQRLPLWNARNGNGSTTTHCHPTGVSVQRRLPIQSHQQRILNQRFHHQRMHHGTSEPIPSGVATPSSLDSASVDGGKSHTGNNNNINNNHNGQQSQKSQQQAGLAAKLNVLAQSNLNNNNTTNQPGSMTPASNRTGLDSNQNQKQNLNADSRRSSSVDPDADADDVVDAAHGGAFEDDMQALLPKCSRRSRDELSQSRTSLVSSSEGGILAEGETSSEDDEEEPVEAEDEGEESSRDSSDNSPPCDLGLMERLLVTHPMWFLPGIQRSGAVHLLQGKEEGTFIVRGSSQPNTMAVSVRLPQDTGPYIEHYLIQSHDNVLSLESSRFTFGSIPSLIAHYAQCCDELPVQLMLPRVLREANNRKKLSSLALLGQEFWSYVSSPALLGPLTPSVAPSKDQQLLDAKSPLSLTETSGLGTATFFSDTVSKPPPTGAPPLPGGGLFSPTGSGQLLGFFSQAGTPSDTTNSSLSSFTTSGGQHMQLLSPNSVDSVILTMSPVDNPGHYLPGSTGAPMAPLCPSVVDQQLSTFKVAQTAPEVDQVRPQRPKPPNTLNLKPPAPPLRWSKPHSPDQNGSANGNFTVTTTVTFSMENGGGGGSGPTVGNGNGKFVEVTTPAASNPFNALLNGQASTFQTFAKRLSPEGECKDTLSSQGSSSNDSRWPPPARKLLTSPMTPLTPSGGSSSSGGKSRKSRAGKESQHYKESDILESPPMQYCASALSDKISDYEDVWSHDPSDRASLLTSFRPALDTVGGVMNRRPDLLAETPSTPTPTQQSHLTPCEEETTATPNESSSQSLLQFSGDVPARSRAGLLLPNLSGQVPPVAMTKSMTAAEDDGGDTTPTAEGQANGASRSKQGSPFYAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAMLQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLCHPRNKMSIQSSGPGDSLRAYTLQLAQDPSSTFARNIENFICCTKESREAAPQVVMRNMRQFMSGMKNYLVKHGEGKFHAELETARARLKSDEFLNLDAMLETVMHQLVVLPLREHLYGIFVDHYQRSEDIQLLAQNVRYACEREAADFGIRPTVTPPSQAALRLIANLLWRLQEAELPLDKLELFLCVISTVFDATGCPRGQQLGADDFLPVLVYVVAKCGFVGAEIEAEFMWGLLQPTLLNGEPGYYLTALCSAVQVLKTFMASEGESGSGSLDWRSSCLPACSSVLRVIIPDECNGSLQTRTLPVRPHTTTREVCRIIAHKARITNPQDYALFKLVDGEETLLTDAECPQDARLAAKGKHCMLAYKRIDAKIAWPTAQLAGH
What is the function of this protein?
Potential Ras effector protein.  May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP (By similarity).
What are the official names of this protein?
Protein sprint, SH2 poly-proline-containing Ras-interactor protein.
What is the protein family that this protein belongs to?
Belongs to the RIN (Ras interaction/interference) family.
Protein: SSBP1_YEAST
Sequence: MSAEIEEATNAVNNLSINDSEQQPRAPTHKTVIDPEDTIFIGNVAHECTEDDLKQLFVEEFGDEVSVEIPIKEHTDGHIPASKHALVKFPTKIDFDNIKENYDTKVVKDREIHIKRARTPGQMQRGGFRGRGGFRGRGGFRGGFRGGYRGGFRGRGNFRGRGGARGGFNGQKREKIPLDQMERSKDTLYINNVPFKATKEEVAEFFGTDADSISLPMRKMRDQHTGRIFTSDSANRGMAFVTFSGENVDIEAKAEEFKGKVFGDRELTVDVAVIRPENDEEEIEQETGSEEKQE
What is the function of this protein?
Functions in the transition of mRNAs from translation to an mRNP complex destined for decapping.  High-copy-number suppressor of decapping defects.  Overexpression suppresses decapping defects in both DCP1-2 and DCP2-7 mutations.  Acts to promote translational repression of mRNA in conjunction with DHH1 and subsequent mRNA localization to P bodies.  Promotes translational repression of mRNA during glucose deprivation.
What are the official names of this protein?
Single-stranded nucleic acid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the RRM GAR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Cytoplasm, P-body. Cytoplasm, Stress granule.
Protein: MGSA_ECO27
Sequence: MELTTRTLPSRKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: FRMR_ECOHS
Sequence: MPSTPEEKKKVLTRVRRIRGQIDALERSLEGDAECRAILQQIAAVRGAANGLMAEVLESHIRETFDRNDCYSREVSQSVDDTIELVRAYLK
What is the function of this protein?
Repressor of the frmRAB operon.
What are the official names of this protein?
Transcriptional repressor FrmR.
What is the protein family that this protein belongs to?
Belongs to the FrmR/RcnR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHSD_COXBU
Sequence: MDMVDRTSRRGYRDWFVQRITALLSGIYAVFVIVFLLVHHPISYPQWHALFSHLIMKIFTLIVIFSILWHAWIGMWTIFTDYVKNKPIRLALETLVCLLLVGYFVWAIEFLWIAR
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase hydrophobic membrane anchor subunit.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATP8_HUMAN
Sequence: MPQLNTTVWPTMITPMLLTLFLITQLKMLNTNYHLPPSPKPMKMKNYNKPWEPKWTKICSLHSLPPQS
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: NADK_CHRSD
Sequence: MQPFKTIGLIGRLGSPNAVETLKRLLRFLGTRELDVIVDERTATVLLNHGYPEASRSRLGELCDLVIVVGGDGSLLSAARVLCQTQTPVLGVNRGRLGFLTDISPDDVEERIGEVLDGHFESEQRFLLEAEVFRAGKQVGTASGLNDVVIHPGKAARMIEFELFIDGQFVYSQRSDGLIIATPTGSTAYALSGGGPIVHPRLEAITLVPMFPHTLSSRPIVVDAASEVTIHIGETNQAYPHVSCDGQTQVVSKPGDIMVVRRKRERLTLIHPRGHNYFETCRTKLGWSSRLGE
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 4CLL7_ARATH
Sequence: MEKSGYGRDGIYRSLRPTLVLPKDPNTSLVSFLFRNSSSYPSKLAIADSDTGDSLTFSQLKSAVARLAHGFHRLGIRKNDVVLIFAPNSYQFPLCFLAVTAIGGVFTTANPLYTVNEVSKQIKDSNPKIIISVNQLFDKIKGFDLPVVLLGSKDTVEIPPGSNSKILSFDNVMELSEPVSEYPFVEIKQSDTAALLYSSGTTGTSKGVELTHGNFIAASLMVTMDQDLMGEYHGVFLCFLPMFHVFGLAVITYSQLQRGNALVSMARFELELVLKNIEKFRVTHLWVVPPVFLALSKQSIVKKFDLSSLKYIGSGAAPLGKDLMEECGRNIPNVLLMQGYGMTETCGIVSVEDPRLGKRNSGSAGMLAPGVEAQIVSVETGKSQPPNQQGEIWVRGPNMMKGYLNNPQATKETIDKKSWVHTGDLGYFNEDGNLYVVDRIKELIKYKGFQVAPAELEGLLVSHPDILDAVVIPFPDEEAGEVPIAFVVRSPNSSITEQDIQKFIAKQVAPYKRLRRVSFISLVPKSAAGKILRRELVQQVRSKM
What is the function of this protein?
Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors (PubMed:15677481, PubMed:18267944).  Acts as a carboxylate--CoA ligase that can use various carboxylates as substrates (PubMed:15677481, PubMed:18267944).  Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester (By similarity).
What are the official names of this protein?
4-coumarate--CoA ligase-like 7, 4-coumarate--CoA ligase isoform 6, At4CL6.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: ISPF_CHLAB
Sequence: MNAENDSSLPKPQWIYRVGIGQDSHRFLSESSAKPCILAGVIFENSPGFQANSDGDIIFHAICNAISSVTHRIILGEVADELLHTRGITDSSVYLSEAIKSLKSNQMISHAAITIEGNRPKFLPKLSAMRQSIASALNIPLGSVGITATSGEGLSDFGCGDGVQCFCILTIMEYCG
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.