PharMolix/UniProtQA huggingface dataset:
Protein: COA7_HUMAN
Sequence: MAGMVDFQDEEQVKSFLENMEVECNYHCYHEKDPDGCYRLVDYLEGIRKNFDEAAKVLKFNCEENQHSDSCYKLGAYYVTGKGGLTQDLKAAARCFLMACEKPGKKSIAACHNVGLLAHDGQVNEDGQPDLGKARDYYTRACDGGYTSSCFNLSAMFLQGAPGFPKDMDLACKYSMKACDLGHIWACANASRMYKLGDGVDKDEAKAEVLKNRAQQLHKEQQKGVQPLTFG
What is the function of this protein?
Required for assembly of mitochondrial respiratory chain complex I and complex IV.
What are the official names of this protein?
Cytochrome c oxidase assembly factor 7, Beta-lactamase hcp-like protein, Respiratory chain assembly factor 1, Sel1 repeat-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the hcp beta-lactamase family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=The import in the mitochondrion intermembrane space is mediated by CHCHD4/MIA40.
Protein: SDC4A_XENLA
Sequence: MSPTLMFVLLLCGVAAESIRETETMDPTSMLEYESSGSFPDEVFDDDEIDEDDDYAIDEDDEDYSGSGTDKFDIDDNDEDEEEEETATLGNQIPELDFDQTKTGRKIETNEIDNEIWSPTKPKILEPSNEISMASTGSEGFFQRTEVIVAIVAGTLVGLVVAISFIVFLVIRRNQNGDLVKKPIYKKTSTMEV
What is the function of this protein?
Cell surface proteoglycan.  Regulates non-canonical Wnt signaling, being necessary and sufficient for fibronectrin-mediated translocation of dvl2/dsh to the plasma membrane.  Required for proper convergent extension movements during gastrulation, which shape the neural plate, and for subsequent neural tube closure.
What are the official names of this protein?
Syndecan 4-A, Syndecan-4.1, xSyn4.1.
What is the protein family that this protein belongs to?
Belongs to the syndecan proteoglycan family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GET3_MALGO
Sequence: MATTTTVDDAQPPTLQNILDQKSLKWIFCGGKGGVGKTTTSCSLAIQLAKVRESVLLISTDPAHNLSDAFGQKFGREAVKVNGFSNLSAMEIDPTSSMQEMIEQSEQRGGALAPFMQDLAFAIPGVDEAMGFAEIMKLVKSMEYSVVVFDTAPTGHTLRFLSFPSVLEKALTKFSSFGKSLGPMFQQFQSMMGGGANAQEDMFAKLEGMRQVITEVNSQFKDETKTTFVCVCIAEFLSLYETERLIQELTQYGIDTHAIVCNQLLYPPPGSQCEHCRVRKAMQDKYVHEMMDLYAEDFNVVKIPLLTEEVRGPEKLSSLSEYLMHPYQPPQ
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: SBMC_EDWTE
Sequence: MQVKIESLAAQPLFALRVQGPFAQSLGPGFERLMAWSTRHGLQGQWMALYYDNPREVAPEALRADVALTTATTALPSDGEASGIRWDTLAGGLYALAQVRVIDNDFATPWVALFDQALPASGYRPDGGPCFERYLSDGRASGEWLLELGVPVRKS
What is the function of this protein?
Inhibits the supercoiling activity of DNA gyrase.  Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase.  It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
What are the official names of this protein?
DNA gyrase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAL4_PIG
Sequence: MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKETMDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS
What is the function of this protein?
Force generating protein of respiratory cilia.  Produces force towards the minus ends of microtubules.  Dynein has ATPase activity (By similarity).
What are the official names of this protein?
Dynein axonemal light chain 4.
What is the protein family that this protein belongs to?
Belongs to the dynein light chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: NUSB_GEOMG
Sequence: MGARRLGREIALQLLYSRDYTVGEASSLLEMVFDEAEPGTAAGRAFSDELVRGVLEHRETIDATITEKSKNWAISRMAKVDLNILRLAIYELLYRGDIPKNVTINEAIEVAKKFGTEDSPAFINGILDEVASTLPDKG
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: MDTB_SALAR
Sequence: MQVLPPGSTGGPSRLFILRPVATTLLMAAMLLAGIIGYRFLPVAALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVVTLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPIYSKVNPADPPIMTLAVTSNAVPMTQVEGMVETRVAQKISQVSGVGLVTLAGGQRPAVRVKLNAQAIAALGLTSETIRTAITGANVNSAKGSLDGPERAVTLSANDQMQSADEYRRLIIAYKNGAPVRLGDVATVEQGAENSWLGAWANKAPAIVMNVQRQPGANIIATADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVRDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMLSQQSLRKQNRFSRACERLFDRVIASYGRGLAKVLNHPWLTLSVAFATLLLSVMLWIVIPKGFFPVQDNGIIQGTLQAPQSSSYASMAQRQHQVAERILQDPAVQSLTTFVGVDGANPTLNSARLQINLKSLDERDDRVQQVISRLQTAVATIPGVALYLQPTQDLTIDTQVSRTQYQFTLRATTLDALSHWAPKLLNALQSLPQLSEVSSDWQDRGLAAWVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTANKPGLAALETIRLTGNDGGTIPLSAIASIKQRFTPLSINHLDQFPVTTFSFNVPEGYSLGDAVQAILNTERTLALPADITTQFQGSTLAFQAALGNTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDIIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMYPRDAIFQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIAMVGGLLVSQILTLFTTPVIYLLFDRLSLYVKSRFPRHKEEA
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRP1_PETHY
Sequence: MGSSQKWVIGLLLFSSIFFELTAITLADDKLEESRWGNDNGCGFGRRGCGGGRFGGRGPSFGRGRGAGGGFGGGAGGGAGGGLGGGGGLGGGGGAGGGGGLGGGGGAGGGFGGGAGGGAGGGLGGGGGLGGGGGGGAGGGGGVGGGAGSGGGFGAGGGVGGGAGAGGGVGGGGGFGGGGGGGVGGGSGHGGGFGAGGGVGGGAGGGLGGGVGGGGGGGSGGGGGIGGGSGHGGGFGAGGGVGGGVGGGAAGGGGGGGGGGGGGGGGLGGGSGHGGGFGAGGGVGGGAAGGVGGGGGFGGGGGGGVGGGSGHGGGFGAGGGVGGGAGGGLGGGGGAGGGGGIGGGHGGGFGVGVGIGIGVGVGAGAGHGVGVGSGSGSGGGGNGR
What is the function of this protein?
Responsible for plasticity of the cell wall.
What are the official names of this protein?
Glycine-rich cell wall structural protein 1.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: CD37L_BOVIN
Sequence: MEQPWPPPGPWSLPRAEGEAEEESDLDLSPGSPRCPQLPGGGTQMYSHGIEMACQKQKEFVKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAISELRQREEEWRQKEEALVQRERMCLWNMDAISKDVFNKSFINQDKRKETEDEDKSKSFMQKHEQKIRHFGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEQKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSPNFQPVTVQNHVPHSGVGSIGLLESLPQNPDYLQYSINTALCSLNSVVHKEDDEPKMMDTV
What is the function of this protein?
Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.
What are the official names of this protein?
Hsp90 co-chaperone Cdc37-like 1.
What is the protein family that this protein belongs to?
Belongs to the CDC37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAGV_BACSU
Sequence: MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLYKTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVVTLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPIDKYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYARMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGLALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDTSTGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY
What is the function of this protein?
May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG).
What are the official names of this protein?
Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagV.
What is the protein family that this protein belongs to?
Belongs to the LytR/CpsA/Psr (LCP) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: LEU1_STRM5
Sequence: MTTIERITTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDRDAMALIGRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHREHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVSRAAISAGATTINLPDTVGFTTPEEIREMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQVECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRNKAIVGANAFAHESGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAVEARLRALGFWLEEDELKLVFEQFKGLCEQQRVVTDADLQTLMQGGSNAQGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGDGPVDALFGALSAATGVQLMLDSYHVHSVGIGADARGEANLSVRHEGVEYDGTGTSKDIIEASALAWLDVANRLLRQRQANAASTTEAPAPATA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: PSBM_AGRST
Sequence: MEVNILAFIATALFILIPTAFLLIIYVKTASQND
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: TPIS_HELPJ
Sequence: MTKIAMANFKSAMPVFKSHAYLKELEKTLKPQHFDRVFVFPDFLGLLPNAFLHFTLGAQNAYPRDCGAFTGEITSKHLEELKIHTLLIGHSERRVLLKESPSFLKEKFDFFKGKNFKIVYCIGEDLTTREKGFRAVKEFLSEQLENIDLNYSNLIVAYEPIWAIGTKKSASLEDIYLTHGFLKQILNQKTPLLYGGSVNAQNAKEILGIDSVDGLLIGSASLELENFKTIISFL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUP_BIFA0
Sequence: MPSASGHHQIPAETQRHDDDQTQETAQGLSAAAMLAQEQADDLDAILDDIETVLETNAEEYVSSFVQKGGE
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: NIFB_RHOCA
Sequence: MDPATWAKVKDHPCYSEEAHHHFARMHVSVAPACNIQCNYCNRKYDCSNESRPGVVSERLTPEEAARKVIAVANEVPQLSVLGIAGPGDSAYDWLKTKETFRLVTAQIPDIKLCLSSNGLALPDHLDELVEMNVDHVTITINMIDPEVGAKIYPWIFYNRKRIYGVEASRILHERQMAALDGLVARGILVKVNSVLIPGINDAHLLEVNREVKRRGAFLHNIMPLISAPEHGTHFGLTGQRGPTAAELLAVQEACAGGANLMKHCRQCRADAVGLLGEDRGQEFTLDLVPEAPVYDPAARETYRDWVGAEREDRRAAAEAAQAATEAACAASSPKLLVAVTTQGGGRINQHFGHATEFQVFEVDATGVRFAFHRRCDNYCVDGGGAEDRLDRVIAALDGIDTVLVAKIGDCPREGLASAGITARDSWAHDYIEPAILALYRERMTQKQAITA
What is the function of this protein?
Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms.  NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.
What are the official names of this protein?
FeMo cofactor biosynthesis protein NifB, Nitrogenase cofactor maturase NifB, Radical SAM assemblase NifB.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. NifB family.
Protein: CM3F_CONRE
Sequence: MMSKLGVLLTICLLLFPLSALPLDGDQPADQPAERMQDISPEQNPLFHPDKRGCCPFPACTTHIICRCC
What are the official names of this protein?
Conotoxin reg3f, Reg3.2, Rg3.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MS4A3_HUMAN
Sequence: MASHEVDNAELGSASAHGTPGSEAGPEELNTSVYQPIDGSPDYQKAKLQVLGAIQILNAAMILALGVFLGSLQYPYHFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTISTIAMWCNANCCNSREEISSPPNSV
What is the function of this protein?
Hematopoietic modulator for the G1-S cell cycle transition.  Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
What are the official names of this protein?
Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4.
What is the protein family that this protein belongs to?
Belongs to the MS4A family.
What are the subcellular locations of this protein?
Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear area.
Protein: ATPA1_SYNAS
Sequence: MDTIKAEEISQIISKQIRDYEKKLDVSETGTVLSVGDGIARIYGVENAMAMELLEFPGGIMGMVLNLEADNVGVAVLGDVTHIKEGDIVKRTGKIAQIPVGEALLGRVIDATGEPIDGKGPLGATEFSRIEMIAPGVIKRQPVNEPMYTGLKAIDAMTPIGRGQRELIIGDRQIGKTAIGIDAIIRQKDTGVKCIYVAIGQKKSTVSQIVENLRKHDAMSYTCVVAGCASDPATLQYIAAYAGCSIGEYFRDRGQDALIIYDDLSKQAVAYRQISLLLRRPPGREAYPGDIFYNHSRLLERSARVSADLGGGSLTALPIIETQAGDVSAYIPTNVISITDGQVYLEPSLFFSGIRPAINVGLSVSRVGGAAQVKAMKQVAGTLKLDLAQYRELASFAQFGSDLDKATQAQLDRGVRLVEILKQPQFQPMSLAEEVIVLFAGTRGFLDKYEVEKIKEYEPQVLAYMKSKHQDIMQEIDDKKVISPELEQKIKEALTAFDSVFVAG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha 1, ATP synthase F1 sector subunit alpha 1, F-ATPase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y127_METJA
Sequence: MPKKDVRAFLYDILENMKDIIDFTNDMTFDEFLKDKKTQKAVIRSLEVIGEAVKNLPEDFINKYPQVPWKGMARLRDKLIHHYFGINYEIIWDIVINKVPNDIKEIEEIIKDIEGEDENSI
What is the function of this protein?
Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase.  Probably neutralized by cognate antitoxin MJ0128.  Neutralization may be due to AMPylation by MJ0128.
What are the official names of this protein?
Putative RNase MJ0127, Putative toxin MJ0127.
What is the protein family that this protein belongs to?
Belongs to the HepT RNase toxin family.
Protein: RER1_RAT
Sequence: MSEGDSVGDSVHGKPSVVYRFFSRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMICTFFEAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYKGKEDVGKTFAS
What is the function of this protein?
Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
What are the official names of this protein?
Protein RER1.
What is the protein family that this protein belongs to?
Belongs to the RER1 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: COX2_PHOVI
Sequence: MAYPLQMGLQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETVWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTQELKPGELRLLEVDNRVVLPMEMTIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMTMRPGLYYGQCSEICGSNHSFMPIVLELVPLSHFEKWSTSML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HXK2_RAT
Sequence: MIASHMIACLFTELNQNQVQKVDQFLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEEDKDGIEKAYQILMRLGLNPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLSHEQLLEVKRRMKVEMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
What is the function of this protein?
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:5871820).  Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:5871820).  Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (By similarity).
What are the official names of this protein?
Hexokinase-2, Hexokinase type II, HK II, Hexokinase-B.
What is the protein family that this protein belongs to?
Belongs to the hexokinase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein. Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis.
Protein: DDL_HAEI8
Sequence: MNLKQEKIAVLLGGTSAEREVSFNSGKAVLEALLKQGYNAHPIDPKEYNVANLKKDGFNRAFNILHGRGGEDGTMQGLLEQIGLPYTGCGVMASALTMDKMRTKMLWKAFGLPVADMKVVTRETFSELDPQAVVAKLGLPLMVKPSLEGSSVGLTKVKAVEELKSAVEYALKFDNTILIEEWLAGDELTVPVLDNQVLPAIRIVPEGEFYDYEAKYISDNTQYFCPAGLTPEREQELAILVKRAYDALGCRGWSRIDVMCDAKGNFRLVEVNTNPGMTSHSLFPKSAATVGISFEQLVVKILELSL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REX_CALS4
Sequence: MSKKTIVSMAVIRRLPRYHRCLEELLKNDIKRISSKELSERMGVTASQIRQDLNNFGGFGQQGYGYNVEELYNNLTKILGLDKTYNTIIIGAGNLGQAIANYTRFEKSGFNLKGIFDINPRLFGLKIRDVEVMDVEKVEEFIANNHIDIAILCIPKDNAQYTADRLVKAGIKAIWNFSPIDLKVPDDVILENVHLSDSLFTISYRLNEEELFKKLKGETVKVDG
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPD_AERHH
Sequence: MTDLRPGLTAIVPAAGIGSRMGAECPKQYLQLAGRTILEHTLTRLLSHPAIAQVIVALAPHDRWFDTLAVAADPRILRVEGGAERAFSVLNALHVAAGEWVLVHDAARPCLTHGDLDALIATAMACDGAILGSRVRDTMKRSDGAGNILATVDREQLWHALTPQMFPTRPLRRALEEGLALGATITDEASAMERAGFTVRMVEGRADNIKVTRPEDLSLAGLYLQQQNARQPAQPDSPTEELA
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: TRPF_SYNE7
Sequence: MGLRIKICGLRDPQQAIAIADLGATAIGFIAVRQSPRYVSPAQVAEIAQALQKTHPTVNRVGVFANATAEELEAYVAAGITSLQLHGDETLADCQRWRDRFPALELIKALRIRSTADLALAESFTDCVDTLLLDAYHPQMLGGTGATLDWQALQAFQPSRPWLLAGGLTPENITTALSQLHPAGIDLSSGVERSPGDKDLEKVTALFSSLARNSLLK
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: PENK_MOUSE
Sequence: MARFLRLCTWLLALGSCLLATVQAECSQDCAKCSYRLVRPGDINFLACTLECEGQLPSFKIWETCKDLLQVSRPEFPWDNIDMYKDSSKQDESHLLAKKYGGFMKRYGGFMKKMDELYPMEPEEEANGGEILAKRYGGFMKKDADEGDTLANSSDLLKELLGTGDNRAKDSHQQESTNNDEDMSKRYGGFMRSLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAESLPSDEEGENYSKEVPEIEKRYGGFMRF
What is the function of this protein?
Increases glutamate release in the striatum.
What are the official names of this protein?
Proenkephalin-A.
What is the protein family that this protein belongs to?
Belongs to the opioid neuropeptide precursor family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. Secreted.