PharMolix/UniProtQA huggingface dataset:
Protein: INT9_MOUSE
Sequence: MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPTMQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLILTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSNIPFYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYRSIHGDFSNDFRQPCVLFTGHPSLRFGDVVHFMELWGKSSLNTIIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQAHRMDLMIDCQPPAMSYRRAEVLALPFKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHVLQPPPKPTQPTSSKKRKRVNEDIPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAETLIQIEEDSTHIICDNDETLRVRLRDLVLRFLQKF
What is the function of this protein?
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.  The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.  Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
What are the official names of this protein?
Integrator complex subunit 9, Int9.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH602_VIBCH
Sequence: MAAKHVLFSTDARQKMLSGVNLLANAVKVTLGPKGRHVVLNKSYGAPTITKDGVSVAKEIELADKFENMGAQMLKQVASKANDEAGDGTTTATVLAQALINEGMKAVAAGMNPMDLKRGIDKAVSAAVEKLHQLAKPCSDTQSITQVGAISANSDHAIGEIIAQAMEKVGRNGVITVEEGQALQNELSVVEGMQFDRGYLSPYFINQPKAGCVELENPYVLLVDKKISHIRELLPILESVAKASRSLLIIAEDVDGDALATLVVNSMRGIIKVAAVKAPGFGEQRKAMLEDIAALTAGRVISEEIGLELEKVTLDDLGSAKKVTINKDNTTIVDGAAEPSALQDRIAQIQHQLEHTTSQYDRDKLQQRIAKLSGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALLKIANELSNLQGDNDDQNVGIRIALRAMEEPLRQIAINAGDEASVIANQVKTGDEHYGYNAATGQFGNMLEMGILDPAKVTRSALQFAASIAGLMITTEAMVSEVDKESAA
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 14337_ARATH
Sequence: MSSSREENVYLAKLAEQAERYEEMVEFMEKVAKTVDTDELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNDDHVSIIKDYRGKIETELSKICDGILNLLDSHLVPTASLAESKVFYLKMKGDYHRYLAEFKTGAERKEAAESTLVAYKSAQDIALADLAPTHPIRLGLALNFSVFYYEILNSPDRACSLAKQAFDEAISELDTLGEESYKDSTLIMQLLRDNLTLWNSDINDEAGGDEIKEASKHEPEEGKPAETGQ
What is the function of this protein?
Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes.
What are the official names of this protein?
14-3-3-like protein GF14 nu, General regulatory factor 7.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocates from the cytosol to the nucleus when phosphorylated.
Protein: VD4L_CWPXG
Sequence: MDYCGRECTILRRLLDEDVTYKKIKLEIETCHNLSKHIDRRGNNALHCYVSNKCDTDIKIVRLLLSRGVERLRRNNEGLTPLGAYSKHRHVKYQIVHLLISSYSNSSNELKSNINDFDLYSYMSSDNIDLRLLKYLIVDKRIRPSKNTNYAINGLGLVDIYVTTPNPRPEVLLWLLKSECYSTGYVFRTCMYDSDMCKNSLHYYILSHRESQSLSKDVIKCLIDNNVSIHGRDEGGSLPIQYYWSCSTIDIEIVKLLIKDVDTCRVYDDISQPYIRGVLADYLNKRFRVTPYNVDMEIVNLLIEGRHTLIDVMRSITSYDSREYNHYIIDNILKRFRQQDESIVQAMLINYLHYGDMVSIPIVRCMLDNGATMDKTTDNNYPLHDYFVNNNLVDVNVVRFIVENNGHMAVNHVSNNGRLCMYGLILSRFNNCGYHCYETILIDVFDILSKYMDDIDMIDNENKTLLYYAVDVNNIQFAKRLLEYGANVNATSLSIINTAIQKSSYRRENKTKLVDLLLSYHPTLETMIDAFNRDIRYLYPEPLLACIRYALILDDDFPSKVKYDISGRHKELKRYRADINRMKNAYISGVSMFDILFKRSKRHRLRYAKNPTFINFVSNIKWYKKELTSIITETVKNGERIDSIVDNINTDDNLISKLPMEIQREILYYSIK
What are the official names of this protein?
Ankyrin repeat protein D4L/I2R.
Protein: EFP_BACCN
Sequence: MISVNDFRTGLTITVDNDLWQVIEFQHVKPGKGAAFVRSKLRNLRTGAIQEKTFRAGEKVEKAHIENRRMQYLYASGEAHVFMDNGTYEQIELSEAQIERELKFLKENMEVSIMTYQGEVLGVELPNTVELKVVETEPGIKGDTASNVTKPATLETGLVVQVPIFINEGEMLVINTAEGKYVSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_DICT6
Sequence: MSFEVIQRDKNTRARLGRLKTFHGEVNTPVFMPVGTQGAVKTLSPEEVEEVGAEIILSNTYHLFLRPGQEIIKKGGGLHRFIGWDKPILTDSGGYQVFSLARLRKIEEDGIYFNSHIDGSQYFFTPELVMEVQKALGSDIIMPLDICLGYGASYWETKEALEITLRWLKRSIDYKKNNNMETQLLFGIIQGGFYRELRKEAVERMLDMELPGFALGGISVGEPKDKMYEITDYTVSLLPEEKPRYLMGVGAPEDLVMGVSMGIDMFDCVLPTRLARHGVFYTKTGRRNIKNAQYKEDFSPLEEDCDCYTCRRFTKAYIRHLFLQHETFSYRLLTIHNLRFLFRLMEDVRRSIREGRLEEFKKEFLTQYLANDRENRLEKEEVWNRLLI
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: GIPC2_HUMAN
Sequence: MPLKLRGKKKAKSKETAGLVEGEPTGAGGGSLSASRAPARRLVFHAQLAHGSATGRVEGFSSIQELYAQIAGAFEISPSEILYCTLNTPKIDMERLLGGQLGLEDFIFAHVKGIEKEVNVYKSEDSLGLTITDNGVGYAFIKRIKDGGVIDSVKTICVGDHIESINGENIVGWRHYDVAKKLKELKKEELFTMKLIEPKKAFEIELRSKAGKSSGEKIGCGRATLRLRSKGPATVEEMPSETKAKAIEKIDDVLELYMGIRDIDLATTMFEAGKDKVNPDEFAVALDETLGDFAFPDEFVFDVWGVIGDAKRRGL
What are the official names of this protein?
PDZ domain-containing protein GIPC2.
What is the protein family that this protein belongs to?
Belongs to the GIPC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIK3_ARATH
Sequence: MEGVRFVVWRLGFLVFVWFFDISSATLSPTGVNYEVTALVAVKNELNDPYKVLENWDVNSVDPCSWRMVSCTDGYVSSLDLPSQSLSGTLSPRIGNLTYLQSVVLQNNAITGPIPETIGRLEKLQSLDLSNNSFTGEIPASLGELKNLNYLRLNNNSLIGTCPESLSKIEGLTLVDISYNNLSGSLPKVSARTFKVIGNALICGPKAVSNCSAVPEPLTLPQDGPDESGTRTNGHHVALAFAASFSAAFFVFFTSGMFLWWRYRRNKQIFFDVNEQYDPEVSLGHLKRYTFKELRSATNHFNSKNILGRGGYGIVYKGHLNDGTLVAVKRLKDCNIAGGEVQFQTEVETISLALHRNLLRLRGFCSSNQERILVYPYMPNGSVASRLKDNIRGEPALDWSRRKKIAVGTARGLVYLHEQCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLLDHRDSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLLELITGQKALDFGRSAHQKGVMLDWVKKLHQEGKLKQLIDKDLNDKFDRVELEEIVQVALLCTQFNPSHRPKMSEVMKMLEGDGLAERWEATQNGTGEHQPPPLPPGMVSSSPRVRYYSDYIQESSLVVEAIELSGPR
What is the function of this protein?
Involved in defense response to geminivirus infection.
What are the official names of this protein?
Protein NSP-INTERACTING KINASE 3, LRR receptor-like serine/threonine-protein kinase NIK3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: KAXU1_HOFGE
Sequence: MNTKVVLIMLMITSVILVVEAETLFTANCLDRKDCKKHCKSKGCKEMKCEQIIKPTWRCLCIMCSK
What is the function of this protein?
Blocks voltage-gated potassium channels.
What are the official names of this protein?
Potassium channel toxin alpha-KTx.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family.
What are the subcellular locations of this protein?
Secreted.
Protein: ISPE_METEP
Sequence: MSVLTTRAPAKINLTLHILGRRPGDGYHALESLVAFADVADTLELVPGPDLTLDISGPTAGPAGPLDDNLVLRAARHLAAGVDGLRLGAFRLHKQLPVAAGIGGGSSDAAAALRLLAELNGLALDYPAVIAAARATGADVPVCLDPRARMMRGAGEEIGPVLGLASLPAVLVNPGVPVSTAPVFKALGLAVGQQLDGAEHPVVGASLDADAVLGVIAPARNDLEAPALTVAPVIGEALGLLWAQAGCRLARMSGSGATVFAIFSDDGAAEMAAGAIRAAQPGWWVEPTRLA
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: YNEA_GEOKA
Sequence: MRKTLLHYVLFSFLFALVLAGFVYASSPVDKKEYVTITVAPGDTLWGLAKQYEQEHHMPPDEFIRWVVDVNHLPSPRLAAGEQIVIPVLKSKQGGSVAVNQ
What is the function of this protein?
Inhibits cell division during the SOS response.  Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC to the division machinery.
What are the official names of this protein?
Cell division suppressor protein YneA.
What is the protein family that this protein belongs to?
Belongs to the YneA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PADI3_RAT
Sequence: MSLQRTVRVSLEHPTSAVCVAGVETIVDIYGSVPEGTDMFEVYGTPGVDIYVSPSMERNRERADTRRWCFNKGLEIIVVMNSPSNDLNDSHVQIAYHSSHEHLPLAYAVLYLTCVDITLDCDMNCADRQDRSFVDKRQWMWGPDGYGAILLVNCDRDEVSSDAQDNCDQCVRCLQDLEDMSVMVLRTQGPESLFDDHRLILHTSSCDAERARVFHVCGPEDSCEAYRCVLGPDRMSYEVPRLKGYEERFYVEGLSFPDAGFPGILSFHITLLDDSNEDYSETPIFTDTVVFRVAPWIMTPSTLPPLEVYVCQVRNNTCFVEAVEELARKAGCKLTICPQAENRNDRWIQDEMELGYTQAPHKTLPVVFDSPRNGELQGFPYKRILGLDFGYVTREPPDSSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSRGRRVTQVVRDFLHAQKVQPLVELFVDWLAVGHVDEFLSFVPAPDGKGFRLLLASPGACFRLFQEKQKWGHGRSLLFEGVIGDRRVQTISINQVLSNQSLINFNKFAQSCIDWNREVLKRELGLGESDIIDIPQLFKSEKRKAVAFFPDLVNMLVLGKHLGIPKPFGPIINGRCCLEEKVRSLLEPLGLHCTFIDDFTPYHMLHGEVHCGTNVRREPFAFKWWHMVP
What is the function of this protein?
Catalyzes the deimination of arginine residues of proteins.
What are the official names of this protein?
Protein-arginine deiminase type-3, Peptidylarginine deiminase III, Protein-arginine deiminase type III.
What is the protein family that this protein belongs to?
Belongs to the protein arginine deiminase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PGLRB_NEOFI
Sequence: MHFFQSSLVAATMGAALVAAAPAADLETRSSCTFTSTSALKSGKASCSTITLHNIAVPAGETLDLTGLKTGTTVVFDGTTTFGYKEWEGPLISASGTSITIKQNPGGKIDCDGARWWDGKGGNGGKKKPKFFSAHKLNKSNINGLKVYNIPVHGFSIQSDHLTIKDVLIDNSAGTKLGHNTDAFDVGSSTYITIDGATVYNQDDCLAVNSGEHITFTNGYCNGGHGLSIGSVGGRKNNVVNDVTISNSQIINSQNGARIKTVYGATGSVTGVKFQDVSLKGITKYGIVVQQDYENGKPTGNPTNGVKVSDITFEKVTGSVTSSATDIYILCGSGSCTNWTWSGNSVTGGKKSSKCKNVPAGASC
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.  Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity).
What are the official names of this protein?
Probable endopolygalacturonase B, Pectinase B, Polygalacturonase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 28 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSRP_ACIET
Sequence: MLATHTRTVFYISDGTGITAETFGNAILAQFDIRPRHVRLPFIDTEDKAHQVVRQINHTAELEGKKPIVFTTLVNMSVLKIIEDGCRGMLLDMFGTFIRPLESELGVKSHHRVGRFSDISVSKEYSDRIEAINFSLDHDDGQSHRDLSGADVILIGVSRSGKTPTSLYLAMQCGLKVANYPLIPEDFERRQLPPALVPHRKKIFGLTIDPQRLSQIRNERRPGSRYADLVNCRNEVAEAEAMMRRSGIRWLSTTTKSIEEIATTILQEVRPERLQY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Putative phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: MUTH_YERPP
Sequence: MSVYSLPPAPPSDEHQLFQRAQALSGFTLGELATRAQWVIPADLKRVKGWVGMLLEFYLGASAGSKPEQDFADIGIELKTIPISAQGKPLETTFVCVAPLTGNSGVTWESSHVRHKLARVLWVPVEGERHIPLAERRVGAPLLWSPNVEEEELLRRDWEELMDLIVLGKVESITARHGQVLQLRPKAANSRALTEAIGEFGQPIMTLPRGFYLKKTLTAPMLARHFLL
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_RHOJR
Sequence: MALTTEEKKQVLSEYGLHETDTGSPEAQVAMLTKRIVDLTEHLKMHKHDHHSRRGLLLLVGRRRRLLKYVQKVDIERYRSLIERLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: ADEC_KOSOT
Sequence: MNIIDIIPVARGKQPADLLLKNARIVNVFSGEIERANIAIFRKRIAGIGDYSEGKQVIDLHGAYVVPGLIDAHLHIESSMVSPVEFAKTVLPRGTTTVIADPHEIANVLGLDGVEYLIKSTEGVPLNLYIMLPSSVPATNLENNGARISVMDMIGFVEKHPRVLGLGEVMNYPDIINGDHDSIAKIELLRHKYKKIDGHIPGISGKDLNAYICAFIRSDHECTNVEEAKEKLARGMQILVREGSVARNLDELLPLINEKNYPFISFCTDDKHPNDILNEGHIDYMIRYAIKKGIDPITAVRAATINTARHYNLRSMGAIAPGYKADFVIVDNLEEFRISMVFKDSKLIAENGKLVIDINREQFPLEEVNTFKCPHIEEKDLEVLNKGENIRVIRVYGDDVLTKELRMEPKTKDGRIVSDVNRDILKVASICRYCEEKSMAIGFINGTGLKQGAVATSVGHDAHNMSVIGTNDADMVVAANRVIDMGGGLVIANSGKVLAELPLPIAGLMSNLSSKEVAERLGHLKTVLKELGCEVPDLFMTLSFVQLSVIPELRITNQGLVDVINNNFVSLFIGKEG
What are the official names of this protein?
Adenine deaminase, Adenase, Adenine aminase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
Protein: MPPA1_DICDI
Sequence: MNIIFLKVPSIFKKLNVGNIKILNVNQNSPSIIVNSNNTKSIKNHNYSSFTNNNNNNNKNQVNLVQNKSILSSSSSYKGNNNNNNKLSYTTSSNNNNNNKIEEIVKSTTVSPFTPLNILHPKLVGEKLYSNDNEANNNQKEFKAEISTLPNGIRVVSKQTHEGVCAIGLYINAGTKYESPQDRGVFNLLEKMTFKETKNNSTSEIIKELEEISMNAMASSSREMINVSLEVLRKDLEFVLSILSDQIKSPTYSEEELREQIEVCIRNYEMITNSSSDQLMTEILMGVAFGDAGLGNLVIATPEQYQNITREKLFDALRKYYVGKNIVISVTGAEHSQVIELVDKYFGDIPFTQKDTPSEDSIDSTITYKGGTDACVAGLIHKNHLKSQLQFLIEKQQKLKQQQQQQQPQPQNSNIDDNDNEEELLNLEIEQTKISIEQLELQQVKESSWIIAFPHSGLSTVAENKDIINGLVLQSLLGGGSSYSTGGPGKGMQSRLNLNVVYSSHRVKNCHAFLFVFNKVSLFGISLTTQSGFLQDGIELVLQELLMLRSSMTQQELERAKRSQKSQILQNLEMRSVQCDDMARHILSFGSYKSPEQICKLIDSVTLDDIKKLISKLAQSNPSVVSIVANENEPILTAEQYNQIVKQNSSTLFK
What is the function of this protein?
Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
What are the official names of this protein?
Mitochondrial-processing peptidase subunit alpha-1, Alpha-MPP, Ddalpha-MPP, Inactive zinc metalloprotease alpha-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: FLOA_STAA9
Sequence: MFSLSFIVIAVIIIVALLILFSFVPIGLWISALAAGVHVGIGTLVGMRLRRVSPRKVIAPLIKAHKAGLALTTNQLESHYLAGGNVDRVVDANIAAQRADIDLPFERAAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMNGIEVKAKARITVRANIARLVGGAGEETIIARVGEGIVSTIGSSKHHTEVLENPDNISKTVLSKGLDSGTAFEILSIDIADVDISKNIGADLQTEQALADKNIAQAKAEERRAMAVATEQEMKARVQEMHAKVVEAESEVPLAMAEALRSGNISVKDYYNLKNIEADTGMRNAINKRTDQSDDESPEH
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: MNME_CERS5
Sequence: MDTIYALASARGKAGVAVLRLSGPQAYEAVAAFGVSLPEVRRAALRRLTWNGEVLDEALILLFAEGASFTGERSAEIHLHGSAAAVSSVLQALSELPGLRLADAGEFTRRALDNGRLDLAQVEGLADLLDSETEAQRRQAMRVFSGAIGKRTERWRSDLIRAAALLEATIDFADEDVPVDVTPEVRGLLERLISDLKREVDGSRVAERIRDGFEVAIIGAPNAGKSTLLNALAQREAAITSEVAGTTRDVIEVRMNLGGLAVTLLDTAGLRETHDPVEALGIDRALTRARAADLRIFLLDQSGEVVGLEPEADDLIVQGKADTRLTRGLSVSGLTGDGIQELVEALQDRLLARTAGAGSFTRERHRLAMERAIRAMESAHVQLMQGVPHPELAAEDLRLALRALDSLVGRVDVEALLGEIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSG_BLOFL
Sequence: MRYLPLFVYLNNKPVLVVGGGIVAFRKVQILQKTGAIIQIVAKTLCLNLKTTLFKKKIIWIGKVFQISMLDNVFLVIIATDDTDFNDMVFKYAEKRHILVNTVDDPAKCSFIFPAIIDRSPILIGISSGGQAPVLIRMLKEKLESLIPMSIGYVASLAGIWRNKIKQHITDIVYRRFFWEKLFYNGQISLLVEKGNFRKANRVIKDAVLNQLHNRKQGSVSLVGAGPGDKGLLTIRGLQVIQTADIILYDYLVNPDILDLSRKDANKICVGKIAKKHSISQNNLNHFMIQLAQQGNNVVRLKGGDSFIFGRGGEELQAVSKAGIMFQVVPGITSGIGVAAYAGIPLTHREYAHSVVFMTGHKRHQGDYKINWSLLSDNKQTIVIYMGQLNAVNISKNLICHGRHIYTPVAIISRGTYLDQKILIGTLIELEKLIYMVKKPTLLIIGDVVSLHNEISWFGNG
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: Y258_ARCFU
Sequence: MSIEVRKSIFPSLPIIVFIVFVEVPVLSVIYPLIEVLTIYPLLISLIFSLAVFAYKFQKSEKNLKRLARQIMALFVIFWLLSQITMVVAVESEYHGIVSFRRDIYNAQLSCKG
What are the official names of this protein?
Uncharacterized protein AF_0258.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VME1_IBV6
Sequence: MDNTTNCTLGTEQAVQLFKEYNLFVTAFLLFLTILLQYGYATRNKVIYILKMIVLWCFWPLNIAVGAISCIYPPNTGGLVAAIILTVFACLSFIGYWIQSFRLFKRCRSWWAFNPESNAVGSILLTNGQQCNFAIESVPMVLSPIIKNGVLYCEGQWLAKCEPDHLPKDIFVCTPDRRNIYRMVQRYTGDQSGNKKRFATFIYVKHSVDTGELESVATGGSSLYT
What is the function of this protein?
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
What are the official names of this protein?
Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the gammacoronaviruses M protein family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Note=Largely embedded in the lipid bilayer.
Protein: RUXG_BOVIN
Sequence: MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMVVIRGNSIIMLEALERV
What is the function of this protein?
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.  Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.  As part of the U7 snRNP it is involved in histone 3'-end processing.
What are the official names of this protein?
Small nuclear ribonucleoprotein G, snRNP-G, Sm protein G, Sm-G, SmG.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Protein: RL13_BRADU
Sequence: MKTFSAKPAEVTKKWVLIDAKGLVVGRLATIVAMRLRGKHLPTYTPHVDCGDNVIIINAQHAVLTGRKREQKTYYKHTGYVGHVKERTARQILEGKHPERVLEKAVERMIPRGPLGRVQMGNLRVYGGADHPHEAQQPEKIDIAKLNRKNTRAA
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RL24E_METTP
Sequence: MEERRCSFCNTRITPGTGKLYAKKDGTVYYFCSSKCEKNMRLGRVSRKIKWARKGA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: VRTC_PENAE
Sequence: MGDATATEVFPVMDSIAVAMGDVESQLRVFHNVSRFLPTDDANQVFWWRTTGRHFAIMMHEARYSEARQVELLLFYRFVIAPRLGPRPTSATPWFHSRVAPGIGDGSPIGYSWRWGTGPDTKPLIRHYIEAIGPLTGTTADPLNEFAAKEMLYQLGQLVPGVELPLAWKFAAHIRPSLTDEPTRAVAGSSILIGLQCAPESAGIEVMAGLMTRSPAQVPELLHSIFPRAMRDAYGPDASLDGLNMVRDFVCHDPQGQYLTILGTTAIDCCAAASSRFKVYVTTTNTSFAHLAAVMTLGGRKPEAPESLTQLQELWYALKGLDPEFPVTAEPLSSVCGAANGTASGNPNANVSGVTFYFDIHPKYPFPHIKLQVDISKHTISDLGAINAVTEFLARRGQAADAQAYLNVVRAMVPDEELRTRRGLQAFFAFAFKNGAVDITSYFLPQIYRRYAEVQAELEPRKDCQGRSELSSKLQRRSRFDSY
What is the function of this protein?
Prenyltransferase; part of the gene cluster that mediates the biosynthesis of viridicatumtoxin, a tetracycline-like fungal meroterpenoid with a unique, fused spirobicyclic ring system (PubMed:20534346).  The first step of the pathway is the production of the malonamoyl-CoA starter unit for the polyketide synthase vrtA (PubMed:20534346).  The aldolase vrtJ may be involved in the synthesis of the malonamate substrate for malonamoyl-CoA synthetase vrtB (PubMed:20534346).  The polyketide synthase vrtA then may utilize the malonamoyl-CoA starter unit, followed by sequential condensation of eight malonyl-CoA units to form the polyketide backbone (PubMed:20534346).  The cyclization of the last ring could be mediated by the lactamase-like protein vrtG (PubMed:20534346).  The proposed post-PKS tailoring steps are an hydroxylation at C5 catalyzed the cytochrome P450 monooxygenase vrtE, a hydroxylation at C12a catalyzed by VrtH and/or VrtI, and an O-methylation by the O-methyltransferase vrtF (PubMed:20534346, PubMed:24161266).  VrtC is then proposed to catalyze the transfer of a geranyl group synthesized by vrtD to the aromatic C ring of the tetracyclic polyketide intermediate of viridicatumtoxin to yield previridicatumtoxin (PubMed:20534346).  Finally, the cytochrome P450 monooxygenase vrtK catalyzes the spirocyclization of the geranyl moiety of previridicatumtoxin to afford viridicatumtoxin (PubMed:24161266).
What are the official names of this protein?
Prenyltransferase vrtC, Viridicatumtoxin synthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the tryptophan dimethylallyltransferase family.