PharMolix/UniProtQA huggingface dataset:
Protein: METK_BORBR
Sequence: MANNDFLFTSESVSEGHPDKVADQISDAILDAIFTQDPNARVAAETLCNTGLVVLAGEITTTANVDYIQVARDTIRHIGYDNTEYGIDYKGCAVLVAYDKQSPDIAQGVDRSSEDYLNQGAGDQGLMFGYACDETPDLMPAPIWYAHRLVQRQSELRKDGRLPWLRPDAKSQVTFRYVDGRPAEVDTVVLSTQHSPEISQASIREAVIEDIIKPSFPEGLITPKTKFLVNPTGRFVIGGPQGDCGLTGRKIIVDTYGGACPHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLARQCQVQVSYAIGVAEPINITVYTEGTGVIPDEQIAKLVREHFDLRPKGIVNMLDLLRPIYTKTAAYGHFGRSEPEFSWEATDKAAALKQGA
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3715_OPITP
Sequence: MAESTTPEVVAYPAGDEPLPVLSEVEVRVLGALVEKQLTTPEYYPLTLNALVNACNQTSSRDPIVSYDEATVTRGLDGLRDKKLAYVFAGAESRVVKFGHKFAERFELGRAEVAVLCVLLLRGPQTPGELRSRTGRMHAFESLPDLEQTIAALAAKQPHPLVTRLPRQTGFKEVRVTHLLGGSVSVSSAEPAPEPPPVDRTMQLDQDVAALRQELAELREQFAAFRKQFE
What are the official names of this protein?
UPF0502 protein Oter_3715.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: FRMD8_DANRE
Sequence: MEGDDGDFPPEPSEHSLSQRGSVASSVTRAQDLLVYLANDSAVHLTLEGLGCMNAQELGRSVREALNIPNSAADVFAFWFCSPLLELQLKPKHLPYKLCRQWQDLLYRFTEAPTEDISLDEPSLLFKRSVFYPRAKELQIEDEGVLRLLYDEAKMNILEGRYPCDPEHWLTLGALSCAIELGTELDDQALTAAIREKKLSSFLPAHAALGGGGFLSTLRGRGGRNAEMEQNLVKECRSVCSSAASGSSQEPIALLRQYLRSCHNLPYYGCAFFAGEIDKPAQGLLHRGGRKAVSVGISLEGVYVMDVKEKHVLLGLKFTELSWDHSYPETEGDSHILWLEFDGEEAGTPVNKLLKIYSKQAELMSGLIEFCVELRSVSESAATGTDGEVTPSHEPTSPETNNKTRERRQGKLRRQNSVVCSRVHSLSTINYVDDGKEIKRLKPKRAASFFTRQAQPPTYSAVQVTESLEQG
What is the function of this protein?
Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway.  By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity).  Negatively regulates the Wnt/beta-catenin signaling pathway (PubMed:19572019).
What are the official names of this protein?
FERM domain-containing protein 8, Band4.1 inhibitor LRP interactor, Bili.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane.
Protein: TRA4_BACFG
Sequence: MSKHITEEQRYAISMMLQIPMSKKAIAEAIGVDKSTVYREIKRNCDARSGSYSMELAQRKADRRKQQKHRKEVLTPAMRKRIIKLLKKGFSPEQIVGRSRLEGIAMVSHETIYRWIWEDKRRGGKLHKYLRRQGRRYAKRGSKNAGRGFIPGRVDIDERPEIVELKERFGDLEIDTIIGKNHKGAILTINDRATSRVWIRKLSGKEAIPVAKIAVWALRKVKNLIHTITADNGKEFAKHEEIAQKLEIKFYFCKPYHSWERGANENTNGLIRQYIPKGKDFSEVTNKQIKWIENKLNNRPRKRLGYLTPNEKFKQIINQNSVAFAS
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Transposase for insertion sequence element IS4351, Transposon TN4551.
What is the protein family that this protein belongs to?
Belongs to the transposase IS30 family.
Protein: SUB2_CHAGB
Sequence: MSGEEDLIDYSDDELNNETTAPASNGKKGDAAAAAQNVDKKGSYVGIHSTGFRDFLLKPELLRAIADCGFEHPSEVQQTCIPQAMLGGDIICQAKSGLGKTAVFVLTTLQQVEPVAGECSVLVMCHTRELAFQIRNEYNRFSKYMPDIKTGVFYGGTPIQKDAEVLKNKETHPHIIVGTPGRLNALVRDKHLRLGNVRMFVLDECDKMLDQIDMRRDVQEIFRATPQQKQVMMFSATLADEIKPICRKFMQNPTEHYVDEDTKLTLHGLQQYYIPLEEREKNRKLNELLDELQFNQVIIFVKSTIRATELDKLLRECNFPSIAVHSGVSQEERIRRYKEFKEFNKRICVATDVFGRGIDIERINLAINYDLPADADSYLHRVGRAGRFGTKGLAISFVNSDQDKEVLQQIEKRFEVALPEFPKEGIDASTYMAA
What is the function of this protein?
ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus.  SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly.  May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase SUB2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DECD subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: DUT_NAUPA
Sequence: MKLKIKKLNQEALIPAYQTKEAAGFDLHSIEDVIIKPGERKLIGTGLAFEIEFGYEVQIRPRSGLAFKHGITVLNTPGTIDSDYRGEIKVLLINHSNEAFEIKKEERIAQAVIAPVVQAEIIEVEELSDTERGAGGFGSTGK
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: Y1807_ACIB3
Sequence: MHCDIYRSSKKDEMYIYIARPNYPDETEQADPFEKVPEAVLQAFGRATFVMHLELAPTRKLARVNVLHVLDSLQTKGFFIQMPPEGLINPNAVEPEGLRGA
What are the official names of this protein?
YcgL domain-containing protein ABBFA_001807.
Protein: GOLS6_ARATH
Sequence: MAQMSMTVEKSIKADVTVSHDRVKRAYVTFLAGNKDYWMGVVGLAKGLRKVKSAYPLVVAILPDVPEEHRQILLAQGCIIREIEPVYPPENKTGYSMAYYVINYSKLRIWEFVEYEKMIYLDGDIQVFSNIDHLFDTPRGYLYAVKDCFCEISWSKTPQFKIGYCQQCPEKVTWPVESLGSPPPVYFNAGMLVFEPNLLTYEDLLRVVQITTPTYFAEQDFLNEYFTDIYKPIPSTYNLVMAMLWRHPEHIDLDQISVIHYCANGSKPWRFDETEEHMDREDIKMLVKKWWDIYEDSSLDYKNFVETESKLSPINATLASKESVGDVLISLAPSAA
What is the function of this protein?
Galactinol synthase involved in the biosynthesis of raffinose family oligosaccharides (RFOs) that function as osmoprotectants.  May promote plant stress tolerance (By similarity).
What are the official names of this protein?
Galactinol synthase 6, AtGolS6, GolS-6.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family. Galactosyltransferase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIM41_YEAS7
Sequence: MFRQSIRPLVSNRLTFIRYNSSPAYTAAVSLLKGDLKKAMIAKDEMKKTAIRSMLSAIKNKEIALKGKSADEYSLYDMYSKLISQRKDSINEFLANKRDDLVAKEQGEMDIIKKYMDQLPVSSELDIDQNVKKLLDALKTKAGEKKVQIKEIMGEIDWKSLPTEWKTSPTAIKNSIVKQFKEIFK
What are the official names of this protein?
Altered inheritance of mitochondria protein 41, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AIM41 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: GLO2_SHEDO
Sequence: MLTITAIPAFNDNYFWIVRQADSNFAYVVDPGVAQPVIDYILAHDLILAGVLITHKHADHVGGIQGLQDFYQNSLPVYGPKAEGIAGITHEIIDERTLCLPHLEANVEIIPVPGHTLGHHAYLIEDAIFCGDTLFSVGCGRIFEGSAAQMLASLTKLASLPAHCKIYCAHEYTQSNINFALTVTPNNPNLLQYASWVAKARADNIPSLPSFLSTELAVNPFLRCHTYEVKTAVASQFNTEINDELQTFTLLRKWKDNF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: CURE_ASPTE
Sequence: MADGSDLENNHKPELDRSQPGSTSNGSQEQKDPDEIAPEYATGVRLILVMFTIFVSTILVSLEIGIIATAIPGITNEFRRLDDVGWYGSATFILAAAASPLWGKLFKYVDVKWTYLSAVFIFLVGSIVAAAAPNSVSVIIGRAIQGWGASGVLGGTLIVINYVAPPRNHPLLIGTWMAVFMVSTILGPVIGGGFTSGVSWRWCFWINLPVGGPIIVLLLLFLRIPKHIKKVPATWQEIILALDLPGFCLLLVSLVCLTLALQWGGQTKAWNDGSVIATLVMWIVLSIAFLVTEWFQGQRAMTPFSILTLRMTWSNALFCLISYAALYQVMFYLPIYFQSIHGQSAVKSGVNTLPFLAFFALGAVVSGGVIGKTRYTQPFELLGALIMTAGMALIYILDVDSPQAMYIGAEVLFGFGVGICNQIPMTAVQGFSKQEDVSSATGIMVMCQTLSGAYFVAIAQSLFANRMLATVLSGAGHLDPALVLGTGASELQHVFSGEDLTEVIAAYMVGIKDVFAFSLACAAFAVLLSLIIPFKRLPDHGKKDKPATEEAAEEKSEAEGKVSGDKEENHS
What is the function of this protein?
Efflux pump that is probably involved in the export of dehydrocurvularin (PubMed:23335766).
What are the official names of this protein?
Dehydrocurvularin exporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL1_BACC4
Sequence: MAKRGKKYVEAAKLVDRAAAYSATEAVELVKKTNTAKFDATVEAAFRLGVDPKKADQQIRGAVVLPHGTGKVQRVLVFAKGEKAKEAEAAGADFVGDTDYIGKIQQGWFDFDVVVATPDMMGEVGKLGRVLGPKGLMPNPKTGTVTFDVTKAVNEIKAGKVEYRVDKAGNIHVPIGKVSFEDAKLVENFKTIADTLQKVKPAAAKGTYMKNVTVASTMGPGVRVDVSTLA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: CREB_EMENI
Sequence: MGSFLKSFRKDVGSAAPSVGAPPAKKEPQPLPMTPLEKMLTELGPIRGDGSDKFYGMENFGNTCYCNSILQCLYYSVPFREAVLNYPKRTPIEDLEAALAKALRYQDPNARLEAEALAEKQKAANSPRPGQPPNPQQKPEDKDSPEYKKKLALQTLPLLETTDNSVSYGIPESLFSSLKDMFESIVGSQSRIGIIRPQHFLEVLRRENEMFRTAMHQDAHEFLNLLLNEVVVDVEKAAAKLLESPQPASDVSDSVIPSSSSGSRTPNTTRWVHELFEGLLTSETQCLTCEKASQRDEVFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVSIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGDKPGLACAYVLFYQETTMEAVMKEQEQENTEPPVEVNASTLKQNGFSSSATLAHAHSASQVPTYEDHDRFTGLKRAPTAPQLSTHPEHTTTDSESLPSPAPDPAPLTSLPPIPPIPETPPAPLTSRKSDLQSKKERVKEEKERKAAEKEKEKQRRKEIETRLKDRQRREDDDLKAALEASKVSKEDEDRRNHAENGTSKKNAGGLGRFRSLSQRLSTKESRTSLSRIPPLPNGNHTLSKVPDESEQTHPKSPTPPAPLSRPASQPLNDDLLGSPRADTLAVPTEQEHIKNSKHDRSSHGKWRSFSLRKKSFNILSS
What is the function of this protein?
Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB.  Deubiquitinates the creA catabolic repressor and the quinate permease qutD.  Also plays a role in response to carbon starvation and the control of extracellular proteases activity.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase creB, Carbon catabolite repression protein B, Deubiquitinating enzyme creB, Ubiquitin thioesterase creB, Ubiquitin-hydrolyzing enzyme creB, Ubiquitin-specific-processing protease creB.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
Protein: OPGD_PSEF5
Sequence: MHRRNLLKASMALAAYTGLSASGLLAARAWAGAADGQAQAFDFEQLKAQAKQLAASQYVDTKQVLPPTLAKMTPQNFNAIQYDSKHSLWNELNGQLDVQFFHVGMGFKQPVRMHSVDPKTRQAREVHFRPPLFNYQNTSVDTAQLKGDLGFAGFKLFKAPELDKHDVVSFLGASYFRAVDATGQYGLSARGLAIDTYAKRREEFPDFTQFWFETPDKDSTRFVVYALLDSPSATGAYRFDIDCQAERVVMDVDAHINARTAIEQLGIAPMTSMFSCGTHERRMCDTIHPQIHDSDRLAMWRGNGEWICRPLNNPANLQFNAFADKDPKGFGLVQTDHEFASYQDTVDWYSRRPSLWVEPTTAWGEGSIDLLEIPTTGETLDNIVAFWTPKKPVAAGDSLNYGYKLYWSALPPVGTPLARVHATRSGMGGFVEGWAPGEHYPEVWARRFAVDFTGGGLDRLPAGTGIEPVVTASNGEVKDFNVLVLDEIKGYRITFDWFPTNDSVEPVELRLFIRTNDRTLSETWLYQYFPPAPDKRKYP
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: WSNA_WEIPA
Sequence: KNYGNGVYCNKHKCSVDWATFSANIANNSVAMAGLTGGNAGNK
What is the function of this protein?
Highly active against Gram-positive bacteria M. flavus strain ATCC 400, M. luteus strain CECT241, C. soprogenes strain NCTC533, L. monocytogenes strain ATCC 19111, L. inocua strain ATCC BAA-680D and S. carnosus strain LMG13564.  Less active against B. cereus strain LMG13569, C. thiaminolyticum strain ATCC 15579, E. faecalis strain NCTC8176, L. lactis strain LM0230, L. casei strain ATCC 344, L. lactis strain IL1403, L. jensenii strain ATCC 25258, L. plantarum strain CECT220, L. brevis strain ATCC 8287, L. bulgaricus strain LMG13551, P. acidilactici strain ATCC 25740, P. pentosaceus strain ATCC 33316 and P. pentosaceus strain LMG13560.  Weakly active against L. mesenteroides strain ATCC 19254, L. lactis strain ATCC 1454, L. sakei strain CECT906T, L. lactis subsp.  cremoris strain MC1363 and L. curvatus strain ATCC 51436.  Not active against Gram-negative bacterium S. enteritidis strain ATCC 13076.  The mode of action appears to be non-lytic.  Inactivated by proteinase K, but insensitive to trypsin, alpha-chymotrypsin, pepsin and papain.
What are the official names of this protein?
Bacteriocin weissellin-A.
What is the protein family that this protein belongs to?
Belongs to the bacteriocin class IIA/YGNGV family.
What are the subcellular locations of this protein?
Secreted. Note=Partly adsorbed to cell wall.
Protein: RL19_MYCA9
Sequence: MNTLDFVDQASLREDVPDFRPGDTINVHVKVIEGSKERIQVFKGVVLRRSGGGVSATFTVRKESYGVGVERTFPVHSPNIDHIEILTRGAVRRAKLYYLRELRGKKAKIKEKR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: YTFJ_BACSU
Sequence: MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSKVGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRMLHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY
What are the official names of this protein?
Uncharacterized spore protein YtfJ.
What are the subcellular locations of this protein?
Spore core.
Protein: CCME_RICRS
Sequence: MQKRVRNRLITIIICFCSAFLGISIILYNLEKNIVFFLPPSKINEIEQGKELRVGGLVKTDSINKIADDKISFVITDNIKDCEILYQGALPALFRKGQGIIAIGQLSNGKFIARQLLAKHDENYRPPQ
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: PURA_AZOPC
Sequence: MKVSVLLGLQWGDEGKGKVVDVLTPKYDIVARFQGGPNAGHTLLFADRKYVLCSIPSGVFQGKVNIIGNGVVLDPILFKAETETLTSSCSNLVDKIYISRKAHLILPTHRLLDVAYETQKGNNKIGTTGKGIGPAYTDKVSRNGLRIGDIDYNFEEKYRYAIARHKELLHQMNFQYDLLPLEREWKKSIEVIKRFKRINSDNFINKALIGGRTVLAEGAQGTMLDVDFGSYPFVTSSNTICASACTGLGVAPAKIGDVFGIFKAYCTRVGSGPFPTELSDEIGEKLRNIGNEYGSITKRPRRCGWIDLVALRYAVMINGVTQLIMMKSDVLDTFDTVKACIAYEVNGQKMEDFPFEIGSSVKPIYTELVGWKTNMTKIKSENEFPKAFKDYLLFLEESLGVSIKIVSLGPDREQTIIRE
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7S_LISMO
Sequence: MATKKKTFEEAIAELETIVEALENGSASLEDSLDMYQKGIELTKLCQDKLQSAEKRMAKVVTDAGEEIPFEADGE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1237_SHESH
Sequence: MESLQNHFLIAMPSLKDTFFERSVIYICEHDEKGAMGIMINRPIGIEVNELLLQMQLKEEPELITSLGSKVLIGGPVTPERGFVLHTPQSTWNNSQSLTDELMLTTSRDVLSALGSDTAPEQFIVALGYAGWSRDQLEQELAENTWLSIPATAELLFSTEYEDRWQRATESLGFDIWQLSNQTGHA
What are the official names of this protein?
UPF0301 protein Ssed_1237.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: ADH1_ZEALU
Sequence: IIESVGEGVTDVAPGDHVLPVFTGECKECAHCKSAESNMCDLLRINTDRGVMIGDGKSRFSINGKPIYHFVGTSTFSEYTVMHVGCVAKINPQAPLDKVCVLSCGISTGLGASINVAKPPKGSTVAVFGLGAVGLAAAEGARIAGASRIIGVDLNPSRFEEARKFGCTEFVNPKDHNKPVQEVLAEMTNGGVDRSVECTGNINAMIQAFECVHDGWGVAVLVGVPHKDAEFKTHPMNFLNERTLKGTFFGNYKPRTDLPNVVELYMKKELEVEKFITHSVPFAEINKAFDLMA
What are the official names of this protein?
Alcohol dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYP_HAEIN
Sequence: MRTSQYLFSTLKETPNDAQVVSHQLMLRAGMIRPMASGLYNWLPTGIRVLKKVEKVVREEMNKGGAIEVLMPVVQPAELWEESGRWDQYGPELLRFEDRGNRNFVLGPTHEEVITDLVRREVSSYKQLPLNLYQIQTKFRDEVRPRFGVMRSREFIMKDAYSFHTTQESLQATYDVMYQVYSNIFNRLGLDFRAVQADTGSIGGSASHEFQVLASSGEDDVVFSTESDFAANIELAEAIAIGERQAPTAEMCLVDTPNAKTIAELVEQFNLPIEKTVKTLIVKGADENQPLVALIIRGDHELNEIKAQKHPLVADPLEFADETEIKAKIGSGVGSLGAVNLNIPAIIDRTVALMSDFSCGANIDGKHYFNVNWERDVAIPKVFDLRNVVEGDPSPDGKGTLQIKRGIEVGHIFQLGKKYSEAMKATVQGEDGKPLVMTMGCYGIGVTRVVASAIEQHHDERGIIWPSDEIAPFTVAIVPMNMHKSEAVQKYAEELYRTLQSQGVDVIFDDRKERPGVMFADMELIGVPHMVVIGEKNLDNGEIEYKNRRTGEKEMISKDKLLSVLNEKLGNL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS, but is probably edited in trans by YbaK.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DLTA_STRA1
Sequence: MIHDMIKTIEHFAETQADFPVYDILGEVHTYGQLKVDSDSLAAHIDSLGLVEKSPVLVFGGQEYEMLATFVALTKSGHAYIPVDQHSALDRIQAIMTVAQPSLIISIGEFPLEVDNVPILDVSQVSAIFEEKTPYEVTHSVKGDDNYYIIFTSGTTGLPKGVQISHDNLLSFTNWMISDDEFSVPERPQMLAQPPYSFDLSVMYWAPTLAMGGTLFALPKTVVNDFKKLFATINELPIQVWTSTPSFADMALLSNDFNSETLPQLTHFYFDGEELTVKTAQKLRQRFPKARIVNAYGPTEATVALSAVAITDEMLETCKRLPIGYTKDDSPTYVIDEEGHKLPNGEQGEIIIAGPAVSKGYLNNPEKTAEAFFQFEGLPAYHTGDLGSMTDEGLLLYGGRMDFQIKFNGYRIELEDVSQNLNKSQYVKSAVAVPRYNKDHKVQNLLAYIVLKEGVRDDFERDLDLTKAIKEDLKDIMMDYMMPSKFIYREDLPLTPNGKIDIKGLMSEVNK
What is the function of this protein?
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC.  In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp.  D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
What are the official names of this protein?
D-alanine--D-alanyl carrier protein ligase, DCL, D-alanine--poly(phosphoribitol) ligase subunit 1, D-alanine-activating enzyme, DAE.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_LEGPA
Sequence: MGQKVNPIGIRLGIIKDWNSKWFAGKRYAEFLIQDIKLRNDLKKKLMAAAVSKILIERPANNAVVTILTARPGVIIGKKGGGIETLRKEISDNLGVPVHLNIEEVKKPELDATLVAEGIAQQLEQRVMFRRAMKRAVTSALKAGAKGIKICVSGRLGGAEIARSEWYREGRVPLHTFRADIDYGTAESKTTYGIIGVKVWIFKGEILPQKKRSTESAQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: HDA_ESCF3
Sequence: MNTPAQLSLPLYLPDDETFASFWPGDNSSLLAALQNVLRQEHSGYIYLWAREGAGRSHLLHAACAELSQRGDAVGYVPLDKRTWFVPEVLDGMEQLSLVCIDNIECIAGDELWEMAIFDLYNRILESGKTRLLITGDRPPRQLNLGLPDLASRLDWGQIYKLQPLSDEDKLQALQLRARLRGFELPEDVGRFLLKRLDREMRTLFMTLDQLDRASITAQRKLTIPFVKEILKL
What is the function of this protein?
Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).  Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity).
What are the official names of this protein?
DnaA regulatory inactivator Hda.
What is the protein family that this protein belongs to?
Belongs to the DnaA family. HdA subfamily.
Protein: ECO1_YARLI
Sequence: MKTYRAKRKYLSESEDDVFSSSPTQSPETSPLQPPNESRLNIKAAQAVSPCQKRAKVVKKPAKTKAPVQMTLSLGQTTSTTCKTCGMTYQVAYGPDISAHKSFHSTALNGPKWKPSVSAVVVDKSKTYTVYKSRLLSHPCVSQFLKLVNSELNAPEPILSSQAAVYVYVVDQRAVGCVLVDRITKCRHVDIQTGTLGLKEYPAVMGVSRMYVSQLFRRTGIVTKLLDLAKSDFIYGMELEKNQVAFTQPSEGGLKVAENWAGTVRVYREGE
What is the function of this protein?
Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together.  In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase.  Acts by acetylating the cohesin complex component SMC3 (By similarity).
What are the official names of this protein?
N-acetyltransferase ECO1, Establishment of cohesion protein 1.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ECO subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL10_METBF
Sequence: MEEEKHHTEHVPEWKKDEIENIMELIQSHKVFGMVGIEGILATKIQKIRRDLKDVAVLKVSRNSLTERALNQLGESIPEMNKYLDKQTALVFTNESPFKLYKVLEQTKTPSPIKGGAIAPADIIVQKGPTSFPPGPILGELQSAGIPASIDAGKVAVKETKVVCKAGEVVSQKLATMLTKLEIYPLIVGLDLRAVYDNGAIYEPELLAIDESQYFSDITRAAQSAFNLAVNTAYPTSATIGTLLAKAFAESKNLGVNAVVFDSGVMDALLAKAHVQMTSVASEAADKDANAVDDQLREVLGAAASAAAAVAKEPEKKEEVKEEEEEEEEEDHSEEDGMAGLGSLFG
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10, Acidic ribosomal protein P0 homolog.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: SSDH_PAENI
Sequence: MLATLASATSEDAVAALEAACAAQTSWARTAPRVRAEILRRAFDLVTARSEDFALLMTLEMGKPLAEARGEVAYGAEFLRWFSEETVRDYGRYLTTPEGKNKILVQHKPVGPCLLITPWNFPLAMATRKVAPAVAAGCTMVLKPAKLTPLTSQLFAQTMMEAGLPAGVLNVVSSSSASGISGPLLKDSRLRKVSFTGSTPVGKRLMSDASRHVLRTSMELGGNAPFVVFEDADLDKAVEGAMAAKMRNMGEACTAANRFLVQESVAQEFTRKFAAAMGALSTGRGTDPASQVGPLINNGARDDIHALVTAAVDAGAVAVTGGAPVDGPGYFYQPTVLADVPNNAAILGQEIFGPVAPVTTFTTEQDAIKLANASEYGLAAYLYSRDFNRLLRVAEQIEFGMVGFNAGIISNAAAPFGGVKQSGLGREGGSEGIAEYTTTQYIGIADPYEN
What is the function of this protein?
Catalyzes the NAD(P)(+)-dependent oxidation of succinate semialdehyde to succinate, which may enter the citric acid cycle.  Is involved in the catabolism of 4-methylaminobutanoate produced from nicotine.  Acts preferentially with NADP(+) as cosubstrate but can also use NAD(+).  To a lesser extent, is active also towards butyraldehyde (8. 5% of the activity observed with succinate semialdehyde) and propionaldehyde (1. 6% of the activity observed with succinate semialdehyde) as substrates.
What are the official names of this protein?
Succinate-semialdehyde dehydrogenase, SsaDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.