PharMolix/UniProtQA huggingface dataset:
Protein: TSR3_SULIN
Sequence: MKVYVIDYHKDDPKKCTGRKLVKLKLAELTRVGRGIILNPFSERTLSINDKDILIKSGITIIDTSWNNTSQNEFKNVRGEHRRLPILFAGNPIHYGIAYKLSSLEALMATLYILDEVKEAIKFSNVVKWGHTFIELNKELLEAYRNKDEEEIKKIEKEIIEKILRK
What is the function of this protein?
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M. jannaschii 16S rRNA.  It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
What are the official names of this protein?
16S rRNA aminocarboxypropyltransferase.
What is the protein family that this protein belongs to?
Belongs to the TDD superfamily. TSR3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK2_STRCO
Sequence: MTDSHTAGPFIAAIDQGTTSSRCIVFDRDGRIVSVDQKEHEQIFPKPGWVEHDATEIWTNVQEVVAGAVEKAGITRDDIKAIGITNQRETTLVWDKNTGEPVHNAIVWQDTRTDALCKELGRNVGQDRFRRETGLPLASYFAGPKARWLLDNVDGLRERAEAGDLLFGTMDTWVIWNLTGGVNGGKHVTDVTNASRTMLMNLHTMAWDEKIAESIGVPMQMLPEIRSSAEVYGEITGGRLGELLGGIPVASALGDQQAALFGQTCFSEGETKSTYGTGTFMVMNTGDKLINSYSGLLTTVGYKIGDQDTVYALEGSIAVTGSLVQWMRDQMGLISTAAEIETLALTVEDNGGAYFVPAFSGLFAPYWRSDARGVIAGLTRYVTKAHLARAVLEATAWQTREIADAMTKDSGVELTALKVDGGMTSNNLLMQTLADFVDAPVVRPMVAETTCLGAAYAAGLAVGFWNSTDDLRANWRRAAEWTPRMDADIRDREYKSWLKAVERTMGWLEDEE
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase 2, ATP:glycerol 3-phosphotransferase 2, Glycerokinase 2, GK 2.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: SCP9_ARATH
Sequence: MSLILKFMLLILLVSSHHVRSGSIVKFLPGFKGPLPFELETGYIGIGEEENVQFFYYFIKSDKNPQEDPLIIWLNGGPGCSCLSGLFFENGPLALKNKVYNGSVPSLVSTTYSWTKTANIIFLDQPVGSGFSYSKTPIERTSDTSEVKKIHEFLQKWLIKHPQFLSNPFYVVGDSYSGMIVPALVHEISKGNYICCNPPINLQGYVLGNPITHIEFEQNFRIPYAHGMSLISDELYESLKRICKGNYFSVDPSNKKCLKLVEEYHKCTDNINSHHTLIANCDDSNTQHISPDCYYYPYHLVECWANNESVREALHVDKGSIGEWIRDHRGIPYKSDIRSSIPYHMNNSINGYRSLIFSGDHDITMPFQATQAWIKSLNYSIIDDWRPWMIKGQIAGYTRTYSNKMTFATVKGGGHTAEYLPEESSIMFQRWISGQPL
What is the function of this protein?
Catalyzes the formation of 1,2-bis-O-sinapoyl beta-D-glucoside and an unidentified compound 1.
What are the official names of this protein?
Serine carboxypeptidase-like 9, Sinapoylglucose--sinapoylglucose O-sinapoyltransferase, SST, Sinapoylglucose--sinapoylglucose acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Secreted.
Protein: QUEF_SYNAS
Sequence: MQKSTPPEDLSRLTLLGREAKPSRKLETFPNRHPDRDYIVTMETAEFTCVCPMTGQPDFADLHISYIPDASILESKSLKLYLWSYRNEGIFHEHVTNVILEDVVAALSPRWCKVTANFGVRGGISITVEAEYKKPGWSKP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BPT_VIBC3
Sequence: MSSDIQQIRIGLTNNHPCSYLADRMERVAVAIDPQMQTPETYEVLMANGFRRSGDTIYKPHCDHCQSCQALRIPAPDFVPSKSQKRLLKLLSQEFHWQLKPELDEDWYALYARYIFARHRHGSMYPPNKMEFAKFARAKWLNTQYLHLYQGEKLVAIAVTDLLPNSASAFYTFYDPDISISLGTLAVLCQLNYCQQTKKQWLYLGYQIDECPAMNYKVRFNPHQRLVNQRWRG
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
What are the official names of this protein?
Aspartate/glutamate leucyltransferase.
What is the protein family that this protein belongs to?
Belongs to the R-transferase family. Bpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7S_STRPD
Sequence: MSKTKTFEENLQDLETIVNKLENGDVPLEEAISEFQKGMLLSKELQKTLQAAEKTLVKVMQADGTEVDMDD
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_XANOM
Sequence: MNQDHPEFDSEDLAQNPPETDPLKAEIESLRSEIALVKADALRERADLENQRKRIARDVENARKFANEKLLGELLPVFDSLDAGLTAAGTQPSPLRDGLDMTYKQLLKVAADNGLTLLDPVGQPFNPDQHQAISQGEAEGIAPGHVVQVFQKGYLLNDRLLRPALVVVAKQD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYAB_AMAPH
Sequence: MSDINAARLPSFFFPIPCISDDIEMVLTRGESLC
What is the function of this protein?
Cyclic heptapeptide that belongs to the MSDIN-like toxin family responsible for a large number of food poisoning cases and deaths (PubMed:27978833).  Cycloaminide B is non-toxic to mammals but shows immunosuppressive activity, probably through the inhibition of the action of interleukin-1 and interleukin-2 (PubMed:27978833, PubMed:8441706).
What are the official names of this protein?
Cycloamanide B proprotein.
What is the protein family that this protein belongs to?
Belongs to the MSDIN fungal toxin family.
Protein: NU1C_CUCSA
Sequence: MIIDTSQVQDIHSFSRLEFLKEFYGILWVLVPILTTVLGITIGVLVIVWLEREISAGIQQRIGPEYAGPLGVLQALADGTKLLFKENLLPSRGDTRLFSIGPSIAVISILLSYSVIPFGYRLVLADLPIGVFLWIAISSVAPIGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSSSTVDIVEAQSKYGFWGWNLWRQPIGFVIFLISSLAECERLPFDLPEAEEELVAGYQTEYSGIKFGLFYVASYLNLLVSSLFVTVLYLGGWDISIPYILGYELFEINKVYEVFGMTISIFITLAKTYLFLFISIATRWTLPRLRIDQLLNLGWKFLLPISLGNLLLTTSFQLFSL
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic, NAD(P)H dehydrogenase subunit 1, NDH subunit 1, NADH-plastoquinone oxidoreductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL36_HAHCH
Sequence: MKVRASVKKMCRGCKIIRRNGAVMVICSTEPRHKQKQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LURA1_HUMAN
Sequence: MEGTVESQTPDLRDVEGKVGRKTPEGLLRGLRGECELGTSGALLLPGASSTGHDLGDKIMALKMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSTTDRLDSVSIGSFLDTVAPSELDEQGPPGAPRSEMDWAKVIAGGERARTEVDVAATRLGSLRAVWKPPGERLQGGPPESPEDESAKLGFEAHWFWEQCQDDVTFL
What is the function of this protein?
Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines.  Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106).  In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration.  Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).
What are the official names of this protein?
Leucine rich adaptor protein 1, Leucine repeat adapter protein 35A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERPA_ECO5E
Sequence: MSDDVALPLEFTDAAANKVKSLIADEDNPNLKLRVYITGGGCSGFQYGFTFDDQVNEGDMTIEKQGVGLVVDPMSLQYLVGGSVDYTEGLEGSRFIVTNPNAKSTCGCGSSFSI
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: ACKA_CLOTE
Sequence: MKILVINCGSSSLKYQFINMTNEDVLAKGLVERIGMEGSILTHKVNDEKYVIQEPMKDHKDAIKLVLDALTDKEHGVIEDMSEISSVGHRVVHGGEKYANSVLIDEDVMKSLEECIKLAPLHNPPNIIGINACKALMPNTPMVAVFDTAFHQTIPEYAYIYPLPYELYKKYGIRKYGFHGTSHRYVSKRVAELMGKDIKDLKIITCHLGNGASICAVNEGKSVETSMGFTPLEGIAMGTRSGSIDPAILPFLMKELNLNLDDLNNLLNKKSGVYGISGVSSDFRDIEEAAEEGNDRAKLALDVFHYKVRRFIGSYAAAMGGVDCVVFTAGLGENSAESREEICKNLEFLGIKINEKKNNEGRGFAKVISEDNSKVKVFVIPTDEELMIARDTNEIVSNLK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTBB2_METBF
Sequence: MATEYALRMGDGKRVFLTKEKIMAEIEAGTANAADLGDIPALNDNEMDKLAEILMMPGKTVSVEQGMEIPVTHDIGTIRLDGDQGNSGVGIPSSRLVGCMMHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGDLMKLFKIDKAKESMEHAAEHLTRDTVWVMQKLFASGADGVNFDTTGAAGDGDMYGTLYAIQALRKEFPDMYIEAGMAGEMVLGMHGELEYDGVRLAGSWPHEQAPLIAKAGANVFGPVCNTNTSKTSAWNLARAVTFIKAAVEASPIPCHVNMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPMGMPISHIMASGMTGIRAAGDLVARMEFSKNMRIGEAKEYVAKKLGVDKMDLVDEHVMRELREELDIGIITSVPGAAKGIAAKMNIEKLLDIKINSCNLFRKQIA
What is the function of this protein?
Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of MtbC.
What are the official names of this protein?
Dimethylamine methyltransferase MtbB2, DMA methyltransferase 2, DMAMT 2, Dimethylamine--corrinoid protein methyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the dimethylamine methyltransferase family.
Protein: UBIG_AZOVD
Sequence: MSNVDHAEIAKFEALAHRWWDRESEFKPLHEINPLRVNWIEEHVRLAGKKVLDVGCGGGILSEAMALRGAAVTAIDMGEAPLAVARLHQLESGVEVDYRQSTVEALAAEMPGRFDVVTCLEMLEHVPDPASVIHACHTLVKPGGQVFFSTINRNPKAYLLAIIGAEYLLKLLPRGTHDFRKFIRPSELGAWCRASGLAIGDIVGLTYNPLTRHYKLGTDVDVNYMIQTWREE
What is the function of this protein?
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
What are the official names of this protein?
Ubiquinone biosynthesis O-methyltransferase, 2-polyprenyl-6-hydroxyphenol methylase, 3-demethylubiquinone 3-O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
Protein: TFAS_ECOLI
Sequence: MILDRHITSRGYVCMRPATIAPLTPYDKWDGEKWVTDTEAQHSVAVDAAEAQRQSLIDTAMASISLIQLKLQAGRKLMQAETSRLNTVLDYIDAVTATDTSTAPDVIWPELPEE
What are the official names of this protein?
Putative protein TfaS, Putative tail fiber assembly protein homolog from prophage CPS-53.
What is the protein family that this protein belongs to?
Belongs to the tfa family.
Protein: TONB_XANCP
Sequence: MTEQLVIHRHDYDAGNQGLSWARIIGIAFVIALHLTALMMLLIPAVAPKAPAEKERTTMVTLVDAPPPPPPPPPPPPPEDKPPPPVKNLSPPKPSPVPPPPEAPVVDVPEPRPSDIVTPPSPPAPPAPPSDIGASVDISSKNMNPPKYPPAAFRAGVQGEVILIVDVDANGNVTNVSVEKSSRNRDLDRAAMDAARKWKFNASTVNGQKAAGRVRVPVNFALN
What is the function of this protein?
Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates.  It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity).
What are the official names of this protein?
Protein TonB.
What is the protein family that this protein belongs to?
Belongs to the TonB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Periplasmic side.
Protein: Y255_MYCGE
Sequence: MESENQIAILDYIFNQVNQPNQPKIVWFSGEGEDEKINFLIRLNDFFKPKFVENTNDSSFLLSFRNHVETKNSTPLTQANFANIANKLLAVLFGSLQWKQLNKPTGNWFLVILFLALLWLRQCWLKLQLTKISKFVNQKGILSFIKQQWPILTTLVTVGTTLGTPVFSLTIAQQDGIKQNAGNDVFIFLIIFSVFSISLGLVSSLIFLVSSLFSIRQKKTLDALDKVLSKFIDKYFFLDEKEIKKQLKYQFKNNGVCFFYGFDFDQAEFLEQSMNLMLLLKQTNCFILVGCKESEMTLIKNKIEPNINLKQNSFYLDLSNEISQVEQISKFNLLFRQLRLSSELFYLEDFFDYLTTAKQIVNFLF
What are the official names of this protein?
Uncharacterized protein MG255.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PVCB_PSEAE
Sequence: MNAYLSDQPVRLSPLRDEQGNQPRFGLLLEPGRPGMHVGELPAQWLKGLARSHHLLLLRGFAAFADAESLTRYCHDFGEVMLWPFGAVLELVEQEGAEDHIFANNYVPLHWDGMYLETVPEFQVFHCVDAPGDSDGGRTTFSSTPAALQLADSSELELWRRASGRYQRSAAHYSSRSAAPIVERHPRREFPILRFCEPPVEGDASFINPSEFHYDGIAPEQRGELLASLRRCLYHPQAHYAHRWRSDDLVIADNLTLLHGREAFAHRAPRHLRRVHIHAEPALRNPHLQRD
What is the function of this protein?
Involved in the biosynthesis of paerucumarin, a cyclized isocyano derivative of tyrosine (PubMed:18689486, PubMed:18824174).  Catalyzes the 2-oxoglutarate-dependent oxidation of tyrosine isonitrile (PubMed:25866990).
What are the official names of this protein?
Tyrosine isonitrile desaturase, PaPvcB, Paerucumarin biosynthesis protein PvcB.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
Protein: ENO_BACAN
Sequence: MSTIIDVYAREVLDSRGNPTVEVEVYTESGAFGRAIVPSGASTGEHEAVELRDGDKSRYLGKGVMNAVNNVNEAIAPEIVGFDVTDQAGIDRAMIELDGTPNKGKLGANAILGVSMAVAHAAADFVGLPLYRYLGGFNAKQLPTPMMNIINGGSHADNNVDFQEFMILPVGAPTFKESIRMGAEVFHALKAVLHDKGLNTAVGDEGGFAPNLGSNREALEVIIEAIEKAGYKAGENVFLGMDVASSEFYNKETGKYDLAGEGRTGLTSAEMVDFYEELCKDFPIISIEDGLDENDWDGHKLLTERIGDKVQLVGDDLFVTNTQKLAEGIEKGISNSILIKVNQIGTLTETFEAIEMAKRAGYTAVVSHRSGETEDATIADIAVATNAGQIKTGSMSRTDRIAKYNQLLRIEDELGEIAVYDGIKSFYNIKR
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL24_SYNFM
Sequence: MKGQKSYRIKKNDTVMVVTGKDKGKSGKVLRVIYKKDRAIVEKLNMIKRHMKPSQQNRQGGILEKESPIHISNLMLICAKCTDPTRVGYKVLDDNKKVRFCKKCNEVID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: CLC14_MOUSE
Sequence: MRPALALCLLCPAFWPRPGNGEHPTADRAACSASGACYSLHHATFKRRAAEEACSLRGGTLSTVHSGSEFQAVLLLLRAGPGPGGGSKDLLFWVALERSISQCTQEKEPLRGFSWLHPDSEDSEDSPLPWVEEPQRSCTVRKCAALQATRGVEPAGWKEMRCHLRTDGYLCKYQFEVLCPAPRPGAASNLSFQAPFRLSSSALDFSPPGTEVSAMCPGDLSVSSTCIQEETSAHWDGLFPGTVLCPCSGRYLLAGKCVELPDCLDHLGDFTCECAVGFELGKDGRSCETKVEEQLTLEGTKLPTRNVTATPAGAVTNRTWPGQVYDKPGEMPQVTEILQWGTQSTLPTIQKTPQTKPKVTGTPSGSVVLNYTSSPPVSLTFDTSSTVVFILVSIAVIVLVVLTITVLGLFKLCFHKSRSSRTGKGALDSPGVECDAEATSLHHSSTQCTDIGVKSGTVA
What are the official names of this protein?
C-type lectin domain family 14 member A.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: FOLC_MYCTU
Sequence: MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSPQRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQYVATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGRWDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPKVMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAHNAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGASALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALAAGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAARTLFGRDPQ
What is the function of this protein?
Is involved in the bioactivation of the antituberculous drug para-aminosalicylic acid (PAS).  Is able to use hydroxy-dihydropteroate (H2PtePAS) as substrate, which is the product formed by the action of DHPS (FolP1) on PAS, leading to hydroxy-dihydrofolate (H2PtePAS-Glu).  This compound inhibits dihydrofolate reductase DHFR (DfrA), the next enzyme in the folate pathway, and thus disrupts the folate-dependent metabolic pathways.
What are the official names of this protein?
Dihydrofolate synthase/folylpolyglutamate synthase, DHFS / FPGS, Folylpoly-gamma-glutamate synthetase, Tetrahydrofolylpolyglutamate synthase.
What is the protein family that this protein belongs to?
Belongs to the folylpolyglutamate synthase family.
Protein: PKRI1_XENLA
Sequence: MAKETGTAKPARQKKEPQPLVIPKNATDEQRLKLERLMRNPDKPATVPERPKEWSPRSAPEFVRDVMGSSAGAGSGEFHVYRHLRRREYQRQEFLDGMSEKQRLDEEYKKKLIQNKMLEEERTAKRRLKRQKLKEKKKMCKKGKKEEKKEDKDGHTDPENSAESSDKSDLEDQ
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome (By similarity).  Binds double-stranded RNA (By similarity).
What are the official names of this protein?
PRKR-interacting protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the PRKRIP1 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: YQGF_CLOBH
Sequence: MRILGLDIGDRTIGIAISDPLGFTAQGITTIRRKSEAYDLEEIKKICDKYEVDTIVSGLPKNMNGTLGPQSEKVLEFCDLIKEHLNIEIKMWDERLTTVAATRAMLEADLSRSKRKKIVDKVAATYILQGYLDSLSK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOTB_ECO45
Sequence: MTTNTVSRKVAWLRVVTLAVAAFIFNTTEFVPVGLLSDIAHSFHMQTAQVGIMLTIYAWVVALMSLPFMLMTSQVERRKLLICLFVVFIASHVLSFLSWSFTVLVISRIGVAFAHAIFWSITASLAIRMAPAGKRAQALSLIATGTALAMVLGLPLGRIVGQYFGWRMTFFAIGIGALITLLCLIKLLPLLPSEHSGSLKSLPLLFRRPALMSIYLLTVVVVTAHYTAYSYIEPFVQNIAGFSANFATALLLLLGGAGIIGSVIFGKLGNQYASALVSTAIALLLVCLALLLPAANSEIHLGVLSIFWGIAMMIIGLGMQVKVLALAPDATDVAMALFSGIFNIGIGAGALVGNQVSLHWSMSMIGYVGAVPAFAALIWSIIIFRRWPVTLEEQTQ
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RTCB_OSTLU
Sequence: MTTGADADARRTYDEERAYVSAVSPTKLVVAKGFVPNMRVPGEIYVNERLRELVLDELRAYCDEDRRGGGYSPAVKQIANVAALPGVVRASIALPDVHSGYGFAIGNVAAFDCGDDDAIVSPGGVGFDINCGVRLLRTNLTEAEVGPVKEALAQSLFDHIPVGVGSRGIIPTSPAALEAALEMGMDWSLREGYAWAEDKEHTEEYGRMLNADPSKVSARAKKRGLPQMGTLGAGNHYAEIQVVDEIYDEFAAKKMGIDRVGQICIMIHSGSRGLGHQVATDSLTAMERAMERDGIEVNDRQLACAKISSQEGQDYLAAMACAANYAWVNRSSMTFLCRQAFAKMFGKPPDELDMHVVYDVSHNIAKFEEHIVDGEMKTLLVHRKGSTRAFPPHHPLIPVDYQYTGQPVLIGGTMGTCSYILTGTEKGMRDTFGSTCHGAGRARSRNKSRHVLQYEDVLAKLKTKGIAIRVASPKLVMEEAPESYKDVTEVVNTCHDAGISKKCVKLRPIAVVKG
What is the function of this protein?
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester.  May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
What are the official names of this protein?
RNA-splicing ligase RtcB homolog, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
Protein: EFTS_HELPY
Sequence: MSGISAQLVKKLRDLTDAGMMDCKKALVEVAGDLQKAIDFLREKGLSKAAKKADRIAAEGVVALEVAPDFKSAMIVEINSETDFVAKNEGFKELVKKTLETIKAHNIHTTEELLKSPLDNKPFEEYLHSQIAVIGENILVRKIAHLKAPSSHIINGYAHSNARVGVLIGIKYDNEKNAPKVVELARNIAMHAAAMKPQVLDCKDFSLDFVKKETLALIAEIEKDNEEAKRLGKPLKNIPTFGSRIELSDEVLAHQKKAFEDELKAQGKPEKIWDKIVPGKMERFIADNTLIDQRLTLLGQFYVMDDKKTIAQVVADCSKEWNDDLKITEYVRFELGEGIEKKAENFAEEVALQMK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPGR1_BOVIN
Sequence: MIPTSKGKNTKTQPPLSRMTRDELEDSLFRLREEHMLVKELFWKQQDEIKRMRTALLRLTASGRGLRAEAAADESSGSPLNGGGTESGGTAPSSTSVPRCPGSSCSSSAWAPLLPAAPSLASTRDTDSSTPPGHRAEKPKRESRDRLSYTAPPTFKEHVTNEKARGEVASEPSELGHLMTSDTMQVEEPPKSPEKMWSKDENFAQRSSLESTQKATELRASIKENIQLIRLKKLLHERNTSLAVTKAQLTEVQAAYETLLHKNQGILGAAHNALLSQVNELRAELKEESKKAVSLKSQMEDVSILQITLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSNQPQWSHELGEQLQQKVSQLQDQLDVEMKEKREILLQLSQEKAQNKDLELEVTSLLQKHKQEVEDLQNISTFSQSPDRQSAPATHPALFQETIQIQPCEPKNQEEKKLSQMLSELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNENKDHEAKLERLNQLLDLKNKRINQLEEQLKDVAYGTRQLPLCLKPLPAHENEDKVDISPWHQSENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLVVGPQPLYDFTSQYVVEIDSLFLHYLQGASAQLDLHQAIASEHHTLAAGWICFDRVLETVERVHGSATLTGTGGEVFGVLEYWMRLRFPIRSSLQAYNKRKKAQAYLAANVLGAWEAQKDEPRSGTWKNQNELRVEIIRCCGLRSRSLGAQPSPYVMYRFFTFSDHDTTIIPASSNPYFRDLARFPVLVTSDLDQYLRREALSVYVFDDEDSEPGSYLGRVQVPLLPLAQNKSIQGDFNLTDPVGEPNGSVQVHLDWGSCYLPPENFPKPEAQSEEDTRDGLETSIEEEEASFPPQDQMVSIDTPTEAGQYQAKRKPPQVGERKEREHQVAGYSRRKHGRKTGLQGKNRMEYLSHNLLNGNTLQQVKYIEWKFSGLKISADHVLKNQQKEEEMTSSYSAQILKETPHPVNDKEFCEQASEGSEAQTTDSDEIVTPVSQKCPKADSEKMCIEIVSLAFYPEAEVMCDENVEQVYVEYRFYDLPLSETETPVSLRKPRAGEEIYFHFSKVIDLDPVEQKERRQFLFTMLIGEDPEQGHLKFTVVSDPIEEEKKECQEVGYAYLELWPMLVSGRDILEQDLDIVGPEDQATPIGKLKVSLQAAAALQAIYKEMTEDLCS
What is the function of this protein?
May function as scaffolding protein.  Required for normal location of RPGR at the connecting cilium of photoreceptor cells.  Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.
What are the official names of this protein?
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1, RPGR-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the RPGRIP1 family.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Situated between the axonemal microtubules and the plasma membrane (By similarity). In the retinal photoreceptor cell layer, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (By similarity). Colocalizes with RGPR in the photoreceptor connecting cilium,(at protein level) (By similarity).