PharMolix/UniProtQA huggingface dataset:
Protein: ARP4_ORYSJ
Sequence: MYGGDEVSAIVIDVGSYSCKAGYAGDDTPKAVFPSVVGSIEQTGETDEAKADKEAEAASDSKNGAKPMDVDKAKTKRKLYVGQELEFRRDHMEVISPMKDGTVTDWDIVDNIWNHAFRQRLLINPEEHPMLIAEPSTNTGQQREKAAELMFEKYKVPALFLAKNAVLTSFASGRATSLVVDSGGGSTVVAAVHDGYVLQKSVATSPIGGEFLTDCMMKSLESKGVVIRPRYSFKKKEVGPGEYKVVDLDLPNTTESYKLYCMRAIASDIKESVCRVPDTAFDEVAYANVPTTSYELPDGQTIEVGADRFKIPDILFNPSLSQTIPGVDGFADSMSVRGLPRMVIDSVNRCDVDIRKELLSSILLSGGSSSILQLKERLEKEVLEESSGNTRVKVLASGNSVERRFSVWIGGSILASLGSFQQMWFSKAEYEEHGVSYIQRKCP
What is the function of this protein?
Involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure.
What are the official names of this protein?
Actin-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: RIOX1_DANRE
Sequence: MERKHMSALSIYQSLSGGKTPQAEDKAPPAKKVKRKENGVRPSKKATKKKGTKPLKSSVRSSSSEKEKHEGERDCREMNGKRFDNVALDILLTDLAKVNNSRDRANRLFQWLIHPVQDKSFFRDNWEKKPILIQRQNADYYKGLFSTAEFDRILRNDDVQYGVNLDVTSYTNGKRETHNPPGRALPYTVWDFYESGCSIRMLNPQAFSSTVWQVLSVLQEKFGSMAGANVYLTPPGTQGFAPHFDDIEAFVVQLEGRKHWRVYNPRCEDEVLSLVSSPNFSQDEIGEPVMDVVLEAGDLLYFPRGFVHQGDCLPDAHSLHITISSYQRNSWGDLMLKLMPAALEVAMEEDVEFRKGLPLDYLQYMGVQNSEKEDPRRDRFMAHIQGLMKKLVSFAPVDAAVDQKAKDFLHDCLPPLLTAEEKAGSVYGAPARWGDSEALDVAVELKSQTRIKLVRAGAARLCSDGDTVHLYYTTENSRVYHKEASKSFEMKTEHIDAMEFLIHSYPKFVSVASLPCETAEAKMSLAELLFEKGLIFTAEPLTAQ
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity).  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code.  Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2).  Also catalyzes demethylation of non-histone proteins (By similarity).  Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity).
What are the official names of this protein?
Ribosomal oxygenase 1, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: CBH_CLOPE
Sequence: MCTGLALETKDGLHLFGRNMDIEYSFNQSIIFIPRNFKCVNKSNKKELTTKYAVLGMGTIFDDYPTFADGMNEKGLGCAGLNFPVYVSYSKEDIEGKTNIPVYNFLLWVLANFSSVEEVKEALKNANIVDIPISENIPNTTLHWMISDITGKSIVVEQTKEKLNVFDNNIGVLTNSPTFDWHVANLNQYVGLRYNQVPEFKLGDQSLTALGQGTGLVGLPGDFTPASRFIRVAFLRDAMIKNDKDSIDLIEFFHILNNVAMVRGSTRTVEEKSDLTQYTSCMCLEKGIYYYNTYENNQINAIDMNKENLDGNEIKTYKYNKTLSINHVN
What is the function of this protein?
Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids).  Can hydrolyze the amid bond in major human bile salts, such as glycocholate (GCA), taurocholate (TCA) and taurodeoxycholate (TDCA) (PubMed:7618863, PubMed:15823032).  Shows a slight preference for taurine-conjugated bile acids as substrates (PubMed:7618863).
What are the official names of this protein?
Conjugated bile acid hydrolase, CBAH, Bile salt hydrolase, BSH, CBAH-1, Choloylglycine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C59 family.
Protein: RIMP_SALA4
Sequence: MGVGLSTLEQKLTEMITAPVEALGYELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPISVAYNLEVSSPGLDRPMFTADHYARFQGEEVALVLRMAVQNRRKWQGIIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSX_LEVBA
Sequence: MKIAVDAMGGDYAPDEIVKGIELARDAYPDLEFLLYGQTAKVQPLLQNTTRIELVDAPEVIAMEDEPVRAVRRKKQSSIVLAATAVREGQADAFFSAGNTGAVLAAGLLIIGRIKGIERPGLTTTLPVLQRPDQSSFVMLDVGANADTKPFNVVQYAIMGQYYAQSVMHVDNPRIGLLNNGTEADKGDMAHRAIHDALANMAEINFVGNVESRELLNGAADVVVTDGFTGNATLKAVEGTALSMLKLIKGEIMSGGLGGKIGASMLKPVFRQVRSAMDYSQYGGAVLLGLKAPVVKTHGSTKAETVKNTIGQIQELLASHSADQLGTYFAEHSDEMAALKENLKA
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: RS9_FUSNN
Sequence: MAEKITQYLGTGRRKTSVARVRLIPGGQGVEINGKAMDEYFGGRAILSRIVEQPLALTETLNKFAVKVNVVGGGNSGQAGAIRHGVARALLLADESLKEALREAGFLTRDSRMVERKKYGKKKARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: EF1G1_ORYSJ
Sequence: MALVLHTFDGNKNAFKALIAAEYSGVKVELAKNFQMGVSNKTPEYLKMNPIGKVPILETPDGPVFESNAIARYVTRSKSDNPLYGSSLIEYAHIEQWIDFSATEVDANTGKWLFPRLGFAPYVAVSEEAAIAALKRSLGALNTHLASNTYLVGHSVTLADIVMTCNLYMGFARIMTKNFTSEFPHVERYFWTMVNQPNFKKVMGDVKQADSVPQVQKKAAAPKEQKPKEAKKEAPKEAPKPKAAEKPEEEEEAPKPKPKNPLDLLPPSKMILDEWKRLYSNTKTNFREVAIKGFWDMYDPEGYSLWFCDYKYNDENTVSFVTMNKVGGFLQRMDLCRKYAFGKMLVIGSEPPFKVKGLWLFRGPEIPKFVMDEVYDMELYEWTKVDISDEAQKERVSAMIEDLEPFEGEALLDAKCFK
What is the function of this protein?
Probably plays a role in anchoring the complex to other cellular components.
What are the official names of this protein?
Elongation factor 1-gamma 1, EF-1-gamma 1, eEF-1B gamma 1.
Protein: HIS2_PSEAB
Sequence: MSDTLTRLAAVLEERKNAAPDSSYVASLYHKGLNKILEKVGEESVEAIIAAKDAAASGDCQDLIYETADLWFHSLVMLSALGQHPQAVLDELERRFGLSGHAEKAARQPSA
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAJB_BACC6
Sequence: MSREQIIKDGGNILVTAGAGSGKTTILVSKIEADLKENKTHYSIAAVTFTNKAAKEIEGRLGYSSRGNFIGTNDGFVESEIIRPFIKDAFGNDYPDNFTAEYFDNQFASYDKGLQVLKYQNILGTYSNPKKNFKFQLALDILKKSLVARQYIFSKYFKIFIDEYQDSDKDMHNLFMYLKDQLKIKLFIVGDPKQSIYIWRGAEPENFNGLIENSTDFNKYHLTSNFRCCQDIQNYSNLFNEETRSLIKEKNEVQNVISIADDMPISDILLKLTEEKQVLNIEAELVILVRRRNQAIEIMKELNEEGFNFIFIPQTPLDRATPNATLLKEVIKYVKNDRYSIYDLAAEIVGNLSSREIKEIQKIINELLVPNINQVLINQVLINLFAKLEITLDTREITAFTEVMMTNEFDIAFDTNEYLHKIFTVHSAKGLEFNQVIITASDYNVHYNRDTNEHYVATTRAKDKLIVIMDNKKYSDYIETLMKELKIKNIIKSI
What is the function of this protein?
Component of antiviral defense system Gabija type I, composed of GajA and GajB.  Expression of Gabija type I in B. subtilis (strain BEST7003) confers resistance to phages phi105, phi29, rho14, SpBeta and SBSphiC (PubMed:29371424).  Expression of Gabija type I in E. coli B (strain ATCC 11303) confers resistance to phage T7 (PubMed:33885789).  May be a helicase or contribute to GajA activation (Probable).
What are the official names of this protein?
Gabija protein GajB, Putative helicase GajB.
What is the protein family that this protein belongs to?
Belongs to the helicase family.
Protein: ANMK_YERP3
Sequence: MKSGRFIGVMSGTSLDGVDVVLAAIDERMVAQQASYTHPIPLQLKKDILGMCQGQSTTLSAVGKLDAQLGILFAEAVLALLAKEGLSAQDITAIGCHGQTVWHEPLGEPAFTMQLGDNNRIAAMTQIATVGDFRRRDMAYGGQGAPLVPAFHHALLAHATEKRMVLNIGGIANLSVLLPDSPIRGFDTGPGNMLMDAWIWRNCSLPYDKDACWALSGHVNQPLLEQMFNDPYFRLPAPKSTGREYFNAAWLDKQLARIPGVTAEDIQATLAELTAVSITEQVRLAGGCDRLLVCGGGARNPLVMARISALLSGTEVCTTDDAGIRGDDMEALAFAWLAFRTLSGKPGNLPSVTGASRETILGAVHPVSSW
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: BORC8_HUMAN
Sequence: MEEPEMQLKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQSQGAIYTVEYACSAVKNLVDSSVYFRSVEGLLKQAISIRDHMNASAQGHSPEEPPPPSSA
What is the function of this protein?
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery.  Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
What are the official names of this protein?
BLOC-1-related complex subunit 8, MEF2B neighbor.
What is the protein family that this protein belongs to?
Belongs to the BORCS8 family.
What are the subcellular locations of this protein?
Lysosome membrane.
Protein: DHGB_PRIMG
Sequence: MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEEIKKVGGEAIAVKGDVTVESDVINLVQSAIKEFGKLDVMINNAGMENPVSSHEMSLSDWNKVIDTNLTGAFLGSREAIKYFVENDIKGTVINMSSVHEWKIPWPLFVHYAASKGGMKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPEQRADVESMIPMGYIGEPEEIAAVAWLASSEASYVTGITLFADGGMTQYPSFQAGRG
What are the official names of this protein?
Glucose 1-dehydrogenase B.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: DTD_CYAP4
Sequence: MRVVIQRVKASRVEVDGEVIGTIGRGLNLLVGISRTDTIAEVEWMVRKCLDLRLFPDEKGSLALSVQEMGAELLVVSQFTLYGDGRKGRRPSFDRAAGGEQAQTLYDRFVAGLRQSGLRVETGQFGAMMEVFILNDGPVTLLLEREAPLEQEDNRDD
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3SX2_MICLL
Sequence: MKTLLLTLVVVTIVCLDLGNSLVCYVSGAWQKTCPEGQNKCEKYAVGTMHGSWIYLRGCASTCHEGPYNVCCSTDLCNK
What are the official names of this protein?
Three-finger toxin A2, 3FTx A2, Short chain alpha-neurotoxin A2, MlatA2.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: THIC1_METTH
Sequence: MTQMDEAKKGVITDEMKAVAEAENVTPEFVRRGVASGKIAIPSNLNREEVAAVGIGAGLRTKVNATIGTSTDIVDFDMEEEKARIAIENRADTLMELSVGGDLDEIRRRILDLSPIPVGSVPVYQAAIETIREKGASIYMDEDVMFRAIEKQAKDGIDFMAIHCSVNRETLRRLKRQGREGGLVSRGGAFVSAWMVENGLENPLYENFDYILEIAKEHDFVLSMANAMRAGAIADSTDRAQVQELIVLGELIDRAREAGVQTIVEGPGHIPLNEIKANVILQKKLCRGAPFYMLGPIVTDIGAGYDHIVSSIGAAASAAAGADFICYVTPAEHLALPYPDDVKEGVIATRIGAYVGDMVKGIHNGEKDLEMANARKKLNWEAQFDAAMCPAEARRIRDERPPEDPDTCTMCGEYCAVKIVNEWLDSADTRIFD
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase 1, Hydroxymethylpyrimidine phosphate synthase 1, HMP-P synthase 1, HMP-phosphate synthase 1, HMPP synthase 1, Thiamine biosynthesis protein ThiC 1.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: RUTF_KLEP7
Sequence: MELTDKASFRDAMAHVGAAVNIITTDGPAGRAGFTASAVCSVTDTPPTLLVCLNRSASVWPVFSEHHTLCVNTLAAGQEALSTLFGGKTAMDERFAAADWQTGATGCPRLEAALVSFDCRIDQRVSVGTHDILFCHVVAITRHPEPRGLMWFDRGYHTLMRPAC
What is the function of this protein?
Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway.
What are the official names of this protein?
FMN reductase (NADH) RutF, FMN reductase, NADH-flavin reductase RutF, NADH:flavin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.
Protein: RL4_CHESB
Sequence: MDLKVTTLAGKDAGKVEVSDEIFGLDPREDILHRVVRWQLAKRQQGTHKAKGRAEIARTGAKMYRQKGTGRARHSSARAPQFRGGGKAHGPVPHSHAHDLPKKVRALGLKHALSAKAKSANLIIVDDLAIKEAKTKALVESFAKLGVTNALMIGGAEIDAGFKRAAANIPNIDVLPIQGINVYDILRRGTLVLSKAAVEALEERFK
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: SUMO4_HUMAN
Sequence: MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCEPRGLSVKQIRFRFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY
What is the function of this protein?
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer.  Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity.  Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins.  May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity.  Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
What are the official names of this protein?
Small ubiquitin-related modifier 4, SUMO-4, Small ubiquitin-like protein 4.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
Protein: ILVC_ACTP2
Sequence: MANYFNTLNLRQKLDQLGRCRFMDRNEFADGCNFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRASFTRATENGFKVGTYQELIPTADLVINLTPDKQHSKVVADVVPLMKQGSAFGYSHGFNIVEEGEQIRKDITVVMTAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWASATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYASKLIQYGWETITEALKQGGITLMMDRLSNAAKIRAFELSEEIKVQLNDLYLKHMDDIISGEFSSTMMADWANGDVNLFKWREETGKTAFENSPKADGIKISEQEYFDNGVVMVAMVKAGVEMAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSHVATPILAEKLIPMLQKGDLGEPTPAAEIDNVYLRDINDAIRNHPVELIGQELRGYMTDMKRISSQG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: NADE_HALSA
Sequence: MSAPDTVSPLDLRFSAAELAERRDRIQSFIRDTVAAAGAERCVLGLSGGIDSTTVAHLTVDELGADALHGLVMPGAVSRDQNMSDAERVAEDLGIEYDVVEIDPFVTQLTDVFPDAAGDEVAVGNARARTRAVINYFVANHGDGVVLGTGNRAEAMTGYYTKYGDQAVDCNPIGNLYKMQVRQLARDLGVPEDLVTKAPTAELWADQTDAGELGVDYDTIDAVLAVHVDGGLPASATATHLDIDPSVVETVRDLYGASKHKRAMPPAP
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: LTBP1_RAT
Sequence: MAGAWLRWGLLLWAGLLAWSAHGRVRRITYVVRPGPGLPAGTLPLAGPPRTFNVALDARYSRSSTATSSRSLAGPPAERTRRTSQPGGAALPGLRSPLPPEPARPGAPSRQLHSKAGAQTAVTRFAKHGRQVVRSKVQQDTQSSGGSRLQVQQKQQLQGINVCGGQCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQFCVCKPGTKGKACEITAAQDTMSPVFGGQNPGSSWVPPEPAAKRTSTKKADTLPRVSPVAQMTLTLKPKPSMGLSQQIHSQVAPLSSQNVMIRHGQTQEYVLKPKYFPAPKVVSGEQSTEGSFSLRYGQEQGTAPFQVSNHTGRIKVVFTPSICKVTCTKGNCHNSCQKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVLGASMPKLYQHAQQPGKALGSHVIHSTHTLPLTMTNQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPVGQRVKEVQPGQSQVSYQGLPVQKTQTVHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKQSYHGYTQMMECLQGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCSCKMGFGPDPTFSSCVPDPPMISEEKGPCYRLVSPGRQCMHPLSVHLTKQICCCSVGKAWGPQCEKCPLPGTAAFKEICPGGMGYTVSGIHRRRPIHQHIGKEAVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTSSREHGPGVAEPEVVTAPPEKEIPSLDQEKTRLEPGQPQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEGSTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYKFSEQQRKCIDIDECAQAQHLCSQGRCENTEGSFLCICPAGFIASEEGSNCIDVDECLRPDVCRDGRCINTAGAFRCEYCDSGYRMSRRGHCEDIDECLTPSTCPEEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGSYMCSCHKGYSPTPDHRHCQDIDECQQGNLCMNGQCKNTDGSFRCTCGQGYQLSAAKDQCEDIDECEHRHLCSHGQCRNTEGSFQCLCNQGYRASVLGDHCEDINECLEDSSVCQGGDCINTAGSYDCTCPDGLQLNDNKGCQDINECAQPGLCAPHGECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRATEDSGVDRQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVQGTAEFSEMCPRGKGFVPAGESSYETGGENYKDADECLLFGEEICKNGYCLNTQPGYECYCKEGTYYDPVKLQCFDMDECQDPNSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCVQPTESNEQIEETDVYQDLCWEHLSEEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALVDFSEQYGPETDPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEGSYKCVCLPGYVPSDKPNYCTPLNTALNLDKDSDLE
What is the function of this protein?
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:7593177).  Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (By similarity).  Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (By similarity).
What are the official names of this protein?
Latent-transforming growth factor beta-binding protein 1, LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta-1-BP-1, Transforming growth factor beta-1-masking protein large subunit.
What is the protein family that this protein belongs to?
Belongs to the LTBP family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space, extracellular matrix.
Protein: CIAO3_HUMAN
Sequence: MASPFSGALQLTDLDDFIGPSQECIKPVKVEKRAGSGVAKIRIEDDGSYFQINQDGGTRRLEKAKVSLNDCLACSGCITSAETVLITQQSHEELKKVLDANKMAAPSQQRLVVVSVSPQSRASLAARFQLNPTDTARKLTSFFKKIGVHFVFDTAFSRHFSLLESQREFVRRFRGQADCRQALPLLASACPGWICYAEKTHGSFILPHISTARSPQQVMGSLVKDFFAQQQHLTPDKIYHVTVMPCYDKKLEASRPDFFNQEHQTRDVDCVLTTGEVFRLLEEEGVSLPDLEPAPLDSLCSGASAEEPTSHRGGGSGGYLEHVFRHAARELFGIHVAEVTYKPLRNKDFQEVTLEKEGQVLLHFAMAYGFRNIQNLVQRLKRGRCPYHYVEVMACPSGCLNGGGQLQAPDRPSRELLQHVERLYGMVRAEAPEDAPGVQELYTHWLQGTDSECAGRLLHTQYHAVEKASTGLGIRW
What is the function of this protein?
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins.  Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.
What are the official names of this protein?
Cytosolic iron-sulfur assembly component 3, Cytosolic Fe-S cluster assembly factor NARFL, Iron-only hydrogenase-like protein 1, IOP1, Nuclear prelamin A recognition factor-like protein, Protein related to Narf.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: LEU12_RALSO
Sequence: MLKHPATKYRPFPPIALPDRTWPSKTLTRAPIWMSTDLRDGNQALFEPMNAERKMRMFKMLVQIGFKEIEAAFPAASQTDYDFVRELIEGGHIPDDVTIEVLTQAREDLIRRTMESLRGARRAIIHVYNATSPVFRRTVFNTDREGVKRIAVESAKLIREIAESMPETQWTYQYSPEVFSGTELDFALEVCNAVTEAWDPTPAHKIIFNLPATVEMATPNVYADQIEWMHRHLARRDSILLSVHPHNDRGTAVAAAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQGIDPGLDFSHVNDVARTCEDCTQLPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKPDAIWEMPYLPIDPADVGRTYDSIIRVNSQSGKGGVAYLLESGYGIAMPRRLQVEFSSTVQQLTDASGREATAADIWALFQETYLRADGPIGYVSHRLAERDDGSQHIRLVVNIADREHVCEGVGNGPLDALVQALAAVLAAPVSIHHYEERALGQGANADAIAFAELAAPGVAGSVFGVGIDANLTTASIRAVVGGVNRLAARHAQAQPGQSLLRRGMAPSMELA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: RL22_STRSV
Sequence: MAEITSAKAMARTVRVSPRKSRLVLDNIRGKNVADAIAILKFTPNKAAGIIEKVLNSAIANAENNFGLEKANLVVSEAFANEGPTMKRFRPRAKGSASPINKRTSHITVVVAEK
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: PSBA_CHLMO
Sequence: MTAILERRESTSLWARFCEWITSTENRIYIGWFGVIMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAVIPTSNAIGLHFYPIWEAASLDEWLYNGGPYQLIVCHFFIGICCYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFIIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANAGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVIGIWFTALGLSTMAFNLNGLNFNQSVVDSNGRVLNTWADIINRANLGMEVMHERNAHNFPLDLAAFEAPSINA
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: Y1934_CUPTR
Sequence: MMKGQLAGLMKQAQQMQENMKKMQEQLAQIEVEGQSGAGLVKVVMTCKNDVKRVTIDPSLLAEGEDKDLLEDLVAAAFNDAVRKAEATTQEKMGSMTSGLPLPPGFKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein RALTA_A1934.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.