PharMolix/UniProtQA huggingface dataset:
Protein: LSM6_NEOFI
Sequence: MENGASSEGRDPSAFLGEIIGAPVTVKLNSGVVYRGELQSVDGYMNIALERSEEFVDGKLRRSYGDAFIRGNNVLYISAQ
What is the function of this protein?
Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates.  Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway.  Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs.  LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6. U5 tri-snRNP, and free U6 snRNP).  It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes.  LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm6.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CHLI_CYAPA
Sequence: MKNNNRPIFPFTAIVGQEEMKLALLLNIVDPKIGGVMIMGDRGTGKSTTIRALADLLPEIDIVANDPFNSHPTDIELMSDNVRQLKENGEEISLIQKKVPMIDLPLGATEDRVCGTIDIEKALTEGVKAFEPGLLAQANRGILYVDEVNLLDDHLVDILLDSAASGWNTVEREGISIRHPARFVLVGSGNPEEGELRPQLLDRFGMHAEIRTVKDPTLRVQIVEERSEFDRSPEDFLQEYKLQQEVLRQRIINAQQQLNNVQLNYEIKVKISQVCSELDVDGLRGDIVTNRAAKALAAFEGRDEVTVDDVLRIITLCLRHRLRKDPLEEIDSGQKVEKVFQRIFSNL
What is the function of this protein?
Involved in chlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
What are the official names of this protein?
Magnesium-chelatase subunit ChlI, Mg-protoporphyrin IX chelatase.
What is the protein family that this protein belongs to?
Belongs to the Mg-chelatase subunits D/I family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: RLMN_TRIEI
Sequence: MTQSFKTPTQTPLLGLSLAKLTEWVQQQGQPAYRGKQLYQWIYQKGAKSLADITVFSKQWREEISNFPIGRSVIHHRSVAPDATVKYLLKLSDGNIIETVGIPTYKRLTVCVSSQVGCPMACDFCATGKGGFSRNLEAHEIIDQVLTVQEDFERRVSHIVFMGMGEPLLNTKNVLAAVRSLNQDLGIGQRLITISTSGIRDRIRQLAQHKLQVTLAVSLHASNQRLREHLIPSAKFYPLADLISECREYVKITKRRISFEYILLASFNDLPDHARELAKNMRGFQCHVNLIPYNPISEVDYQRPTQEMIKTFANALAEQNIAVSIRYSRGLEANAACGQLRASRV
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
What are the official names of this protein?
Probable dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSXA_SALSV
Sequence: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLDLIYLRTLAFILVIAVVVQFTEMVVRKTSPALYRLLGIFLPLITTNCAVLGVALLNINLGHHFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rsx electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: F16PA_PSEF5
Sequence: MSRVTLSRYLIEQTRSNNTPADLRFLIEVVARACKEISHAVSKGALGGVLGSMGTENVQGEVQKKLDVISNEILLEANEWGGHLAGMASEEMDNAYQIPGKYPKGAYLLVFDPLDGSSNIDINAPVGTIFSVLRCPNEYLSQNEALNEKAFLQPGTQQVAAGYAIYGPQTMLVLTLGDGVKGFTLDREMGSFVLTHEDIKIPESTQEFAINMSNERHWEAPVKRYVEELLAGDTGPLKKNYNMRWVAAMVADVHRILTRGGLFMYPRDSREPEKPGKLRLMYEANPMSFLVEQAGGASTDGHKRILDIQPEGLHQRVAVFLGSKEEVARVTGYHKE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATC_AZOVD
Sequence: MALERSDVEKIAHLARLGLDDAEIPRTTQTLNDILGLIDRMQAVDTHGIEPLAHPLEATQRLRPDEVTETDHRDAYQAIAPAVENGLYLVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RAB21_CANLF
Sequence: MAAAGGGGGGAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQPGAARRGVQIIDDEPQAQSSGGGCCSSG
What is the function of this protein?
Small GTPase involved in membrane trafficking control (By similarity).  Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general.  As a result, may regulate cell adhesion and migration.  During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity).  Involved in neurite growth (By similarity).  Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity).
What are the official names of this protein?
Ras-related protein Rab-21.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Cell projection, neuron projection. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (By similarity).
Protein: MLIP_HUMAN
Sequence: MLSEQGLLSDCGNNYFQMTSCILSGSIQTTPQVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNRSKSNDYLTLNAGSQQERDQAKLTCPSEVSGTILQEREFEANKLQGMQQSDLFKAEYVLIVDSEGEDEAASRKVEQGPPGGIGTAAVRPKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMAPQQKHGQLTSSPTTSEQLACKPPAFSFVSPTNPNTPPDPVNLEGASVLEEFHTRRLDVGGAVVEESATYFQTTAHSTPFSASKGTSSTLLFPHSTQLSGSNLPSSTAADPKPGLTSEVLKKTTLTSHVLSHGESPRTSSSPPSSSASLKSNSASYIPVRIVTHSLSPSPKPFTSSFHGSSSTICSQMSSSGNLSKSGVKSPVPSRLALLTAILKSNPSHQRPFSPASCPTFSLNSPASSTLTLDQKEKQTPPTPKKSLSSCSLRAGSPDQGELQVSELTQQSFHLPVFTKSTPLSQAPSLSPTKQASSSLASMNVERTPSPTLKSNTMLSLLQTSTSSSVGLPPVPPSSSLSSLKSKQDGDLRGPENPRNIHTYPSTLASSALSSLSPPINQRATFSSSEKCFHPSPALSSLINRSKRASSQLSGQELNPSALPSLPVSSADFASLPNLRSSSLPHANLPTLVPQLSPSALHPHCGSGTLPSRLGKSESTTPNHRSPVSTPSLPISLTRTEELISPCALSMSTGPENKKSKQYKTKSSYKAFAAIPTNTLLLEQKALDEPAKTESVSKDNTLEPPVELYFPAQLRQQTEELCATIDKVLQDSLSMHSSDSPSRSPKTLLGSDTVKTPTTLPRAAGRETKYANLSSPSSTVSESQLTKPGVIRPVPVKSRILLKKEEEVYEPNPFSKYLEDNSDLFSEQDVTVPPKPVSLHPLYQTKLYPPAKSLLHPQTLSHADCLAPGPFSHLSFSLSDEQENSHTLLSHNACNKLSHPMVAIPEHEALDSKEQ
What is the function of this protein?
Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity).  Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1.  Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (By similarity).  Binds chromatin (By similarity).  May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (By similarity).  May also repress MYOCD transcriptional activity (By similarity).
What are the official names of this protein?
Muscular LMNA-interacting protein, Cardiac Isl1-interacting protein, CIP, Muscular-enriched A-type laminin-interacting protein.
What are the subcellular locations of this protein?
Nucleus. Nucleus envelope. Nucleus, PML body. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Protein: ATPG_YARLI
Sequence: MFALRTAARPAARSVGATRNYATLREIEMRLKSIKNIEKITNTMKIVASTKLGKAQRAMATSKVYNEASEKVFENSETAVPENIEKRLWVVVSSDKGLCGSIHSQLARTVRRKLLDFESGEKLIDIVAVGEKIKAQLGRSNPEQMRLSFGGTGKEAPTFEEAAHIADEILALDTQYDDIEIVYNKVLSGISFEPIMKESYSAKAIEDAPKFGQYELEDDVVKNLADFSLANTIYAAMAEGHAAEISARRNAMDNASKNASDMINKYSILYNRTRQAVITNELVDIITGASSLE
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:25759169).  F-type ATP synthases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk (PubMed:27373333).  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (PubMed:27373333).  Part of the complex F(1) domain and the central stalk which is part of the complex rotary element (PubMed:27373333).  The gamma/ATP3 subunit protrudes into the catalytic domain formed of alpha/ATP1(3)beta/ATP2(3) (PubMed:27373333).  Rotation of the central stalk against the surrounding alpha/ATP1(3)beta/ATP2(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta/ATP2 subunits (PubMed:27373333).
What are the official names of this protein?
ATP synthase subunit gamma, mitochondrial, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=The F-type ATP synthase complex is anchored in the mitochondrial inner membrane via the F(0) domain with the F(1) domain and the peripheral stalk extending into the mitochondrial matrix.
Protein: DCUP_ALCBS
Sequence: MTFAPLQNDRFLRALNRETVDRTPIWMMRQAGRYLPEYRAAREHAGSFMDLCKNADLACEVTLQPLERYPLDAAILFSDILTIPDAMGLGLYFETGEGPKFRKVVRTEADVAALPIPDAESDLGYVMNAVSTIRGALNGRVPLIGFSGSPWTLATYMVEGGSSKDFRHLKAMVYSQPELAHAMLDKLAQSVTGYLNAQIRHGAQAVQIFDTWGGALSAEAYKEFSLRYMQQIVDGLIRDNEGRKVPVILFTKNGGLWLESMAATGCDALGLDWTINIGDARRRVGDKVALQGNMDPAVLYASPQAIRAEVKRILDDFGDHPGHIFNLGHGITPQVDPEHAKVFIEAVVELSQK
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LCF1_SCHPO
Sequence: MKVQSKAISKPKEHESAIYRNANFPDHLVETYSDDVHTLFDVFRHSVKQFGNKKAMGYRNLVKEHVETKMVTKVVDGEKKEVPKSWSYFELSDYNYLSFNDIYDKALRYAGALRKLGLNKGDKFELYAPTSAFWLLTAEACLSQSMTIVTAYDTLGEEGLLHSLRESGVRGMYTEGHLLKTLVNPLKEIESLEVIIYRNDAKEEDIKTIQEIRPNLKLIKFADFEKMSPPVEPDPPSPEEICCIMYTSGSTGLPKGVILSHKNMVAIVTAIVKHVPEVTSKDYLLAYLPLAHILEFAFENICLAWGGTIGYANVRTLVDTNCRNCKGDINTFRPTIMVGVPAVWEMVRKGIMSKLNAASAVKRSVFWTAYYTKAKLMRHNLPGSCVLDTAVFNKIRSMGTGGRLRYTLSGGSALSPDTKRFLSIVLCPMLIGYGLTEISAAAMVQNPACFNLDDSAGSLLPCTEMKLVDCEEGNYNSHGHPPRGEIWLRGPSLTRGYLNRDKENKESFTPDGWFRTGDVGELTPEGLLRIIDRKKNLVKTQNGEYIALEKLESRYRTSSLVSNICVYADQTKVKPLAIIVPNEPVVRKLATEQAGLSPDASWEEVCHNKKVRQLVYDDLIRIGRSHHFANIELIQNVVLVPIEFTPENGLVTAAQKLQRRKILDRFKKEIDAAYAE
What is the function of this protein?
Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.  It may supplement intracellular myristoyl-CoA pools from exogenous myristate.  Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities (By similarity).  Appears to play a role in the maintenance of cell viability during stationary phase.
What are the official names of this protein?
Long-chain-fatty-acid--CoA ligase 1, Fatty acid activator 1, Long-chain acyl-CoA synthetase 1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: SYS_CENSY
Sequence: MLDPHILRSRPKDVSDMLQARNVDFDLDALLDADERRRYFMQLADDMRQERNFAGRQVAQFKRDGVDTTAAIKEMKDLSEKLYQAEGEQQSAESEYLELAWTIPNMIDKSVPRGPDETANVVLRKWVGTPTPSVPKGHEELAVGRGLLDMKRAAKVSGARFYYLKGSLVRLNQALISHSLDFLGSRGYTLVQPPYLIRRNAMEGAIIAEDFEDVIYKIEDDDLYLIGTSEHAMAAMHSDEIIEGGLPLRYAGVSPCFRKEAGAHGKDQKGIFRVHQFDKIEQFVFSKPEDSWREHDRMLEITEEFYQGLGIPYRVVLLSSGDMGKVSAKTYDIECWMAAQDAYREVVSCSNCLDFQSRRLKVRFRDRTDEDTQYVHTLNSTLAATSRLLACIIENFQEADGTIRVPQPLQKYVGKEAI
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YTFE_ECO81
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVDVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMEHISLENNILFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1784_RHOCB
Sequence: MAPREPGFAGALPIDGYGPGFFRIAGAVHRGGLLIHAEAAMPWTGFDDLAALRALAGQVDLLLCGMGADIAHLPKGLQVELEALGVMAEPMSTASAARHYNVLLSEGRRVGAALLPMPGAVPTA
What is the function of this protein?
Not required for the biogenesis of c-type cytochromes.
What are the official names of this protein?
Uncharacterized protein RCAP_rcc01784, ORF124.
Protein: ACP_BUCA5
Sequence: MKNIEERIKKIIFEKLDIKQEKIFNDASFIDDLGADSLDTVELIMALEEEFDIEISDEEAEKINTVQKSIDFIQNKNLKK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBO_NOSS1
Sequence: MRYRALIVAFLAVCLGLLTACSDAPASSTRDILTYEQIRGTGLANKCPQLTETSRGSIPLDSSKSYVLKELCLEPTNFFVKEEPANKRQTAEFVAGKLLTRYTSTIDQVSGDLKFNDDSSLTFVEKDGLDFQAITVQLPGGERVPFLFTIKNLVAQTQPGLSSLNTSTDFEGTFKVPSYRGAAFLDPKGRGVVSGYDNAVALPAQADDEDLTRTNVKRAEILNGKISLQIAKVDSSSGEIAGTFESEQPSDTDLGADEPKEVKIRGIFYARVE
What is the function of this protein?
MSP binds to a putative Mn-binding protein and keeps 2 of the 4 Mn-atoms associated with PSII.
What are the official names of this protein?
Photosystem II manganese-stabilizing polypeptide, MSP.
What is the protein family that this protein belongs to?
Belongs to the PsbO family.
Protein: LIPB_ECO57
Sequence: MYQDKILVRQLGLQPYEPISQAMHEFTDTRDDSTLDEIWLVEHYPVFTQGQAGKAEHILMPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVNTLAELGIEAHPRADAPGVYVGEKKICSLGLRIRRGCSFHGLALNVNMDLSPFLRINPCGYAGMEMAKISQWKPEATTNNIAPRLLENILALLNNPDFEYITA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FRIH_PONAB
Sequence: MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFLETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES
What is the function of this protein?
Stores iron in a soluble, non-toxic, readily available form.  Important for iron homeostasis.  Has ferroxidase activity.  Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.  Also plays a role in delivery of iron to cells.  Mediates iron uptake in capsule cells of the developing kidney.
What are the official names of this protein?
Ferritin heavy chain, Ferritin H subunit.
What is the protein family that this protein belongs to?
Belongs to the ferritin family.
Protein: SC65_MOUSE
Sequence: MARGAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLATAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPATSQPRPASGPDGDHDGDGEDWARELRLFGHVLERAACLRRCKKTLPAFQVPYPPRQLLRDFQSRLPYQYLHYAHFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYRGMLDIGDESLTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALAEYMTVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCETNLTPNVGGFFVDKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEDEDFQPREEAMLYHNQTSELRELLDFTHMYLQSDDEMELEETESLPEPEEPLSDAEFEGEGDYEEGLYADWWQEPEAKGDEAEAEPEPELT
What is the function of this protein?
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils (PubMed:27119146).  Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly (PubMed:23959653, PubMed:27119146, PubMed:28115524).
What are the official names of this protein?
Endoplasmic reticulum protein SC65, Leprecan-like protein 4, Prolyl 3-hydroxylase family member 4, Synaptonemal complex protein SC65.
What is the protein family that this protein belongs to?
Belongs to the leprecan family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: XG74_ACET2
Sequence: MVKKFTSKIKAAVFAAVVAATAIFGPAISSQAVTSVPYKWDNVVIGGGGGFMPGIVFNETEKDLIYARADIGGAYRWDPSTETWIPLLDHFQMDEYSYYGVESIATDPVDPNRVYIAAGMYTNDWLPNMGAILRSTDRGETWEKTILPFKMGGNMPGRSMGERLAIDPNDNRILYLGTRCGNGLWRSTDYGVTWSKVESFPNPGTYIYDPNFDYTKDIIGVVWVVFDKSSSTPGNPTKTIYVGVADKNESIYRSTDGGVTWKAVPGQPKGLLPHHGVLASNGMLYITYGDTCGPYDGNGKGQVWKFNTRTGEWIDITPIPYSSSDNRFCFAGLAVDRQNPDIIMVTSMNAWWPDEYIFRSTDGGATWKNIWEWGMYPERILHYEIDISAAPWLDWGTEKQLPEINPKLGWMIGDIEIDPFNSDRMMYVTGATIYGCDNLTDWDRGGKVKIEVKATGIEECAVLDLVSPPEGAPLVSAVGDLVGFVHDDLKVGPKKMHVPSYSSGTGIDYAELVPNFMALVAKADLYDVKKISFSYDGGRNWFQPPNEAPNSVGGGSVAVAADAKSVIWTPENASPAVTTDNGNSWKVCTNLGMGAVVASDRVNGKKFYAFYNGKFYISTDGGLTFTDTKAPQLPKSVNKIKAVPGKEGHVWLAAREGGLWRSTDGGYTFEKLSNVDTAHVVGFGKAAPGQDYMAIYITGKIDNVLGFFRSDDAGKTWVRINDDEHGYGAVDTAITGDPRVYGRVYIATNGRGIVYGEPASDEPVPTPPQVDKGLVGDLNGDNRINSTDLTLMKRYILKSIEDLPVEDDLWAADINGDGKINSTDYTYLKKYLLQAIPELPKK
What is the function of this protein?
Hydrolyzes the glucosidic bonds of unbranched Glc residues in tamarind seed xyloglucan, producing XXXG, XLXG, XXLG and XLLG.  Has low activity on carboxymethylcellulose, lichenan,hydroxyethylcellulose and glucuronoxylan, and no activity on xylan, polygalaturonic acid, wheat arabinoxylan, rhamnogalacturan, curdlan, laminarin, galactomannan, galactan, arabinan and pachyman or amorphous cellulose (By similarity).
What are the official names of this protein?
Xyloglucanase Xgh74A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 74 family.
Protein: Y7720_DICDI
Sequence: MCVCIETLKSLNSNNQGLSSNEQAFGSPSNMNESMVFGSPSSSVLSSSFKGSNSTCATNKSASSAMFSRPFYYE
What are the official names of this protein?
Putative uncharacterized protein DDB_G0274507.
Protein: MSOX_STRSB
Sequence: MSPTYDVIVIGLGGMGSAAAHHLSARGARVLGLEKFGPVHNRGSSHGGSRITRQSYFEDPAYVPLLLRAYELYEELERATGRNVATLCGGVMAGPPDSRTVSGSLRSATEWDLAHEMLDAKEIRRRFPTLAPDDDEVALFEAKAGLLRPENMVAAHLQLATRQGAELRFEEPVLRWEPYRDGVRVHTGENTYTAGQLVICPGAWAPQLLADIGVPITVERQIMYWFQPKGGTGPFVPERHPVYIWEDADGVQVYGFPAIDGPEKGAKVAFFRKGQHTTPETIDRTVHAHEVRAMADHMSALIPDLPGTFLKAATCMYSNTPDEHFVIARHPAHPESVTVACGFSGHGFKFVPVVGEILADLALTGATAHPIGLFDPARLTAPAARGVQP
What is the function of this protein?
Catalyzes the oxidative demethylation of sarcosine.
What are the official names of this protein?
Monomeric sarcosine oxidase, MSOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MSOX subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_ECOHS
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLREGEREGWGEISPLPGFSQETWEEAQSVLLAWVNNWLAGDCELPQMTSVAFGVSCALAELADTLPQAANYRAAPLCNGDPDDLILKLADMPGEKVAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKGQQFAKYVNPDYRHRIAFLEEPCKTRDDSRAFARETGIAIAWDESLREPDFAFVAEEGVRAVVIKPTLTGSLEKVREQVQAAHALGLTAVISSSIESSLGLTQLARIAAWLTPDTIPGLDTLDLMQAQQVRRWPGSTLPVVEVDALERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: RL36_RHOCS
Sequence: MKVVNSLKSMKTRHKACRVIRRRGRVYVINKLNPRFKARQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: LUBX_LEGPA
Sequence: MATRNPFDIDHKSKYLREAALEANLSHPETTPTMLTCPIDSGFLKDPVITPEGFVYNKSSILKWLETKKEDPQSRKPLTAKDLQPFPELLIIVNRFVETQTNYEKLKNRLVQNARVAARQKEYTEIPDIFLCPISKTLIKTPVITAQGKVYDQEALSNFLIATGNKDETGKKLSIDDVVVFDELYQQIKVYNFYRKREVQKNQIQPSVSNGFGFFSLNFLTSWLWGTEEKKEKTSSDMTY
What is the function of this protein?
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.  This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway.
What are the official names of this protein?
E3 ubiquitin-protein ligase LubX, Legionella U-box protein, RING-type E3 ubiquitin transferase LubX.
What are the subcellular locations of this protein?
Secreted. Host cell. Note=Secreted via type IV secretion system (T4SS), and delivered into the host cell.
Protein: RPOY_BACCQ
Sequence: MIFKVFYQEKMTEVPVRENTKVLYLEATSEKDVRTKLNKFAYNIEFVQSVTGNHLEYEKENADLTLAEIV
What is the function of this protein?
A non-essential component of RNA polymerase (RNAP).
What are the official names of this protein?
DNA-directed RNA polymerase subunit epsilon, RNAP epsilon subunit, RNA polymerase epsilon subunit, Transcriptase subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit epsilon family.