PharMolix/UniProtQA huggingface dataset:
Protein: PSBM_CUSEX
Sequence: MEVNILAFIATALLILVPTAFLLIIYVKTAK
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid membrane; Single-pass membrane protein.
Protein: KAPA_PENRW
Sequence: MAERYIPEHRRTQFKAKNQFKPDELRRRREEQQVEIRKAKRDENLAKRRGIQTQDGRIGVGGMAAATESDDEASAIESELNVELPQMVKGVFSDQVEEQIQATTKFRKLLSKERNPPIERVIETGVVARFVEFLRSPHTLVQFESAWALTNIASGSAQQTQVVIEAGAVPIFVELLSSPEPDVREQAVWALGNIAGDSPHCRDFVLGAGALRPLLNLINDGRKLSMLRNATWTLSNFCRGKTPQPDWNTIAPALPVLAKLIYMLDDEVLIDACWAISYLSDGANDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVIINCGSLPALLSLLSSTKDGIRKEACWTISNVTAGNSSQIQAVIDAGIIAPLINLLANGDFKTRKEACWAISNATSGGLQKPDQIRYLVSQGCIKPLCDLLACPDNKIIQVALDGLENILKVGDMDKEAGQPGEARVNRYALFIEEAGGMEKIHDCQNNANEEIYMKAYNIIEKYFSDEDEAGGDIEELAPQQTQTGFTLGTGQQQPGGFNFGNGGDSMDM
What is the function of this protein?
Import of proteins with classical NLS composed of one or two clusters of basic residues is initiated by binding to the importin alpha/beta heterodimer, where importin alpha acts as an adapter subunit to bridge NLS cargos to importin beta, which transports the whole complex through the nuclear envelope (By similarity).  Involved in the nuclear accumulation of the light-dependent developmental regulator velA (PubMed:20543063).
What are the official names of this protein?
Importin subunit alpha, Karyopherin alpha.
What is the protein family that this protein belongs to?
Belongs to the importin alpha family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AIM44_YEAS6
Sequence: MIIRAPIRTKTKSFRGDQMDFKFPSNESLPRGTLEEYHLNNHHLLNDVFAAENGVSRDEDGNSQILSDYTSTSNTNTNSGYSSNGYYSFANISDNTTSSPRIVINQNETARLTSSDSNKSDFFASHDFPGNDSLHYSSSSVVKNQLHSMEAIPEGNITGSISTAFQTIPTADNVSYDIAPSSASSLLPRKSTSKSAILPSTQEAKPMTKLNMEKDIKTIELNNSVVPKPKKKLNRVPTIRRVESSRFSNSRYSSSVSSKSSSSRCSLKRSKAIRCKGGLLYYFTSLGIKIKKKLRKLRLVLRRRLFSYNVQKVPSATNSKTTKSKANINNKSKKRGTNLVNKNSNSTPRQKKSQRYVSNLQRSISSKSLVPVLAPQKKTKPLTVDTKFKANHPQSEDSKVGSNTPRSPLVSYTPSLRRTNSSIRRAASILTASATMTPANNKNSFISVPDNVSHAVTRNSSMYSRSRLVRSKPSTALNAIARQPSIVVENKVIPLSMNRYSIKEEDEYVIDTSSMRELSPVNSVCSSDYDRESSESYSNYADAMETTEVDNKDRVECNNEIQNVNANNEETSNEESYNLMKHYLSTVIAQRIMLRVQIARIQNNKSNVVYMNKSAETNSTIYEDLADTLLTEYEADGSSSQIFDGVSVRADEEEEEDEDDEDDEEEEEENDDEEDEEDEEDEEDDEEEEEKRKEGEGRNLAKEVDELAELSPMRKQSDLSITLRSPFAMLNSAYSNSIISLPTGVVKRSLTLPVGMKI
What are the official names of this protein?
Altered inheritance of mitochondria protein 44.
What is the protein family that this protein belongs to?
Belongs to the AIM44 family.
What are the subcellular locations of this protein?
Bud neck.
Protein: T53I1_HUMAN
Sequence: MFQRLNKMFVGEVSSSSNQEPEFNEKEDDEWILVDFIDTCTGFSAEEEEEEEDISEESPTEHPSVFSCLPASLECLADTSDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEATRGTDELHSPSSPRVEAQNEMGQHIHCYVAALAAHTTFLEQPKSFRPSQWIKEHSERQPLNRNSLRRQNLTRDCHPRQVKHNGWVVHQPCPRQYNY
What is the function of this protein?
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy.  Acts as a positive regulator of autophagy.  In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy.  Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response.  Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function.  Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle.  In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.  Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism.  Can reduce cell migration by regulating the expression of SPARC.
What are the official names of this protein?
Tumor protein p53-inducible nuclear protein 1, Stress-induced protein, p53-dependent damage-inducible nuclear protein 1, p53DINP1.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re- localizes to autophagosomes on autophagy activation.
Protein: RUVA_SYNAS
Sequence: MIAQIRGKLILKTVSMVIIDNHGIGYEVMIPLSTYYELPDVGSEVSLFVYTFFKQDSILLVGFCTENEKQLFKLMISVSGIGPRLAVNVLSGINSSELIHAIANNDLNRLLKVPGLGRKMAQRVILELRDKVSGWTSKEQITFINNKKDAIDQSVMEEDAISALINLGYKSQAAKDAIDRVISEGGENKSLDVILKKALKVLAM
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: ADC_BURMA
Sequence: MKPSQVRSKAFAMPLTSPAFPMGPYRFVNREFLIITYRTDMDRLREIVPEPLEVKEPLVHYEFIRMPDSTGFGDYTESGQVIPVEYKGQPGGYTLAMYLNDHPPIAGGRELWGFPKKLAQPTLQTHIDTLLGTLDYGPVRVATGTMGYKHQELDLEEQAKRLAGANFLLKIIPHVDGSARVCELVRYYLQDIEMKGAWTGPASLQLAPHALAPVADLPVLEIVEARHLLADLTLGLGEVVYDYLAQ
What is the function of this protein?
Catalyzes the conversion of acetoacetate to acetone and carbon dioxide.
What are the official names of this protein?
Acetoacetate decarboxylase, AAD, ADC.
What is the protein family that this protein belongs to?
Belongs to the ADC family.
Protein: KCY_RHORT
Sequence: MIIAIDGPAASGKGTLARRLATQLRFAYLDTGKLYRAVGMAVIKGGADPHDAKAALAAARALDPATLGDRLLSTDTAGKAASVVGAIPEVRAALLDLQRDFATHPPQGAPGAVLDGRDIGTVVCPEAEVKIFVTASVEVRAHRRLQELRSGGHDVKEDDVLRDMRERDARDSGRAVAPMAIAADAVVLDTSRMTAEQALTAALDILAHKSQKT
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_CUTAK
Sequence: MNTPNPRVAKLADQIRVVVAETLERRVKDPRLGFVTITDVRLTGDSRDATLFWTAMGTDKEIAGTEAALESAKGMLRSTVGKRLKLRYAPTLTFVRDATPETAKSIEDALARAAASDAEIARRSQGAMPAGEADPYRHSDEEE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OSA_DROYA
Sequence: YLAAADSAMARTVALQSPCISYLVAFIEQAEQTALGVANQHGINYLRENPDSMGTSLDMLRRAAGTLLHLAKHPDNRSLFMQQEQRLLGLVMSHILDQQVALIISRVLYQVSRGTGPIHSVEFRLLQQRQQQQLRPASAEKQAASAGGSAPVKAEAASTETSSTEAKPAPAATTAVVNDENSNSSQQLPPAATFNDVSNSSTNSNSCGTVSSNQTNXXXXNSSHSSSAISSQSAITVTAPSAPATGATSAXXXAITSDQQQVSKVAAAAAAAAALSNASAAAAAAAAAAAASVGPPTSSSVSAGAAVAQPAAPPPTNAGTTTAV
What is the function of this protein?
Trithorax group (trxG) protein required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation.  Required for the activation of genes such as Antp, Ubx and Eve.  Binds to DNA without specific affinity, suggesting that it is recruited to promoters by promoter-specific proteins.  Essential component of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA.  This complex can both serve as a transcriptional coactivator or corepressor, depending on the context.  Acts as an essential coactivator for Zeste, which recruits the whole complex to specific genes.  In contrast, it acts as a corepressor for Wg target genes, possibly via an interaction with Pan and Gro.  It also acts as a negative regulator for proneural achaete-scute, when it is directly recruited by Pan and Chi.  Also represses E2f activation (By similarity).
What are the official names of this protein?
Trithorax group protein osa, Protein eyelid.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTAP_HYPBU
Sequence: MPDFPPKPSVKADIAIIGGSGLYDPGVLENAKEYKIYTPYGEPSDYIIVGELGGKRVAFLPRHGRGHRIPPHKINYRANIWALKMLGVKWVIAVSAVGSLREDYKPGDIVVPDQFIDMTKSRVYTFFDEGIVAHVSMADPFCEHLRQEIISTARELGYRVHPRGTYICIEGPRFSTRAESRVWREVFKADIIGMTLVPEVNLACEAQLCYATIALVTDYDVWAERPVTAEEVARVMKENTEKAKKILYKLIPRLPPEPDKARCSCCSSLETALL
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Protein: ARL6_HUMAN
Sequence: MGLLDRLSVLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQNILPTIGFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNHPDIKHRRIPILFFANKMDLRDAVTSVKVSQLLCLENIKDKPWHICASDAIKGEGLQEGVDWLQDQIQTVKT
What is the function of this protein?
Involved in membrane protein trafficking at the base of the ciliary organelle.  Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001).  Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity).  Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986).  May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729).  Isoform 2 may be required for proper retinal function and organization (By similarity).
What are the official names of this protein?
ADP-ribosylation factor-like protein 6, Bardet-Biedl syndrome 3 protein.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so- called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane.
Protein: NNJA4_ORYSJ
Sequence: MDDENGLELSLGLSLGGTSGKSKARDAPLEPKAEPQVEESSSKGVSQTPEAPFVHYYQTNAENQEHSSKQRHSPAAPPFGNFWGQPGSSSVPVADGSNEQKPVSSKRKLLSEEISFQKKPNTAAEQPDAFSKSSDGGVKNAPISISTDDGSTGENEDVAESEAEGSNSWLVAQREDSAKGSVVNRGSDRKRSSDDAAVGFQGKRQPSFSGSESSSGKLPQGNPLSLQASNVVAVPYQVPSQVSAPPSITNASNFTPVCTVQLRPPTNNGLAVTMGSTSQVAFGYPAVQLPTLETSSSWAFGAPPQAMSSFTAKDKVERAGISQADDGKKTQEAGASSSALVEDDKKSDRALPLMGSAIRPGIAPNVKFGGSGSYPDLPWVSTTGTGPNGRTISGVTYKFGRNEVKIVCACHGTHMTPEEFMRHASADAPGQENSATLPAFPVGNQAASAQN
What are the official names of this protein?
Protein NINJA homolog 1, OsNINJA1, Ninja-family protein NINJA1, Protein NINJA homolog, OsNINJA, Protein NINJA homolog 2, OsNINJA2.
What is the protein family that this protein belongs to?
Belongs to the Ninja family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CBPY_CANAX
Sequence: MKLSKSTLIATLALTATSTNALVVQNPFSNIQQALKLDLSYDKLTSKLTDTFEQGKANIISTIAKVMNEPLDGLTPEIKNIWSEMLMKFPNSITELNFKAPPKKGKITTQQFDFHVTDAQVPNHKLRIKSTPKDLGIDTVKQYSGYLDVVDEDKHFFYYFFESRNDPKNDPVILWLNGGPGCSSLTGLFFELGPSSIDKNLKPVYNPHSWNANASVIFLDQPINVGYSYSSQSVSNTIAAGKDVYAFLQLFFKNFPEYANLDFHIAGESYAGHYIPAFASEILTHPERNFNLTSVLIGNGLTDPLVQYEYYEPMACGEGGEPSVLEPEECDGMLNSLPRCLSLIESCYESGSVWSCVPATIYCNNGQMGPYQKTGRNVYDIRTMCEGSSLCYSQLEYIDQYLNLPEVKKALGAEVDEYQSCNFDINRNFMFAGDWMKPYQKNVIDLLEKELPVLIYAGDKDFICNWLGNQAWTNRLEWSGSKGFTKAPVKSWKVGKNAAGEVKNYKHFTFLRVFGGGHMVPYDQPENALDMVNRWISGDYKY
What is the function of this protein?
Involved in degradation of small peptides.
What are the official names of this protein?
Carboxypeptidase Y, Carboxypeptidase YSCY.
What is the protein family that this protein belongs to?
Belongs to the peptidase S10 family.
What are the subcellular locations of this protein?
Vacuole. Note=Lysosome-like vacuoles.
Protein: MPIP_DROME
Sequence: MLWETIVEENNCSMDCNISNNTSSSSSINKMSGSRRARRSLELMSMDQEELSFYDDDVVPQDQQRSASPELMGLLSPEGSPQRFQIVRQPKILPAMGVSSDHTPARSFRIFNSLSSTCSMESSMDDEYMELFEMESQSQQTALGFPSGLNSLISGQIKEQPAAKSPAGLSMRRPSVRRCLSMTESNTNSTTTPPPKTPETARDCFKRPEPPASANCSPIQSKRHRCAAVEKENCPAPSPLSQVTISHPPPLRKCMSLNDAEIMSALARSENRNEPELIGDFSKAYALPLMEGRHRDLKSISSETVARLLKGEFSDKVASYRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSERGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPAYNEAYRHFRAKSKSWNGDGLGGATGRLKKSRSRLML
What is the function of this protein?
This protein functions as a dosage-dependent inducer in mitotic control.  It is a tyrosine protein phosphatase required for progression of the cell cycle.  It may directly dephosphorylate Cdk1 and activate the Cdk1 activity.
What are the official names of this protein?
M-phase inducer phosphatase, Cdc25-like protein, Protein string.
What is the protein family that this protein belongs to?
Belongs to the MPI phosphatase family.
Protein: Y1830_STRPB
Sequence: MGFTDETVRFKLDDGDKRQISETLTAVYHSLDEKGYNPINQIVGYVLSGDPAYVPRYNDARNQIRKYERDEIVEELVRYYLQGNGIDVK
What are the official names of this protein?
UPF0297 protein MGAS2096_Spy1830.
What is the protein family that this protein belongs to?
Belongs to the UPF0297 family.
Protein: IL5_FELCA
Sequence: MRMLLHLSLLALGAAYVSAIAVQSPMNRLVAETLALLSTHRTLLIGDGNLMIPTPEHNNHQLCIEEVFQGIDTLKNRTVPGDAVEKLFRNLSLIKEHIDRQKKKCGGERWRVKKFLDYLQVFLGVINTEWTMES
What is the function of this protein?
Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils.  Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity).  Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB.  Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity).
What are the official names of this protein?
Interleukin-5, IL-5, Eosinophil differentiation factor, T-cell replacing factor, TRF.
What is the protein family that this protein belongs to?
Belongs to the IL-5 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYI_ECO57
Sequence: MSDYKSTLNLPETGFPMRGDLAKREPGMLARWTDDDLYGIIRAAKKGKKTFILHDGPPYANGSIHIGHSVNKILKDIIVKSKGLSGYDSPYVPGWDCHGLPIELKVEQEYGKPDEKFTAAEFRAKCREYAATQVDGQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHKGAKPVHWCVDCRSALAEAEVEYYDKTSPSIDVAFQAVDQDALKAKFGVSNVNGPISLVIWTTTPWTLPANRAISIAPDFDYALVQIDGQAVILAKDLVESVMQRIGVTDYTILGTVKGAELELLRFAHPFMGFDVPAILGDHVTLDAGTGAVHTAPGHGPDDYVIGQKYGLETANPVGPDGTYLPGTYPTLDGVNVFKANDIVVALLQEKGALLHVEKMQHSYPCCWRHKTPIIFRATPQWFVSMDQKGLRAQSLKEIKGVQWIPDWGQARIESMVANRPDWCISRQRTWGVPMSLFVHKDTEELHPRTLELMEEVAKRVEVDGIQAWWDLDAKEILGDEADQYVKVPDTLDVWFDSGSTHSSVVDVRPEFAGHAADMYLEGSDQHRGWFMSSLMISTAMKGKAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMNKLGADILRLWVASTDYTGEMAVSDEILKRAADSYRRIRNTARFLLANLNGFDPAKDMVKPEEMVVLDRWAVGCAKAAQEDILKAYEAYDFHEVVQRLMRFCSVEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTADEVWGYLPGEREKYVFTGEWYEGLFGLADSEAMNDAFWDELLKVRGEVNKVIEQARADKKVGGSLEAAVTLYTEPELAAKLTALGDELRFVLLTSGATVADYNDAPADAQQSEVLKGLKVALSKAEGEKCPRCWHYTQDVGKVAEHAEICGRCVSNVAGDGEKRKFA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SINMW
Sequence: MKRDLYETLGVQKSADEKELKSAFRKLAMKYHPDRNPGDNEAEKSFKEINEAYETLKDPQKRAAYDRYGHAAFEQGGMGNGFAGGGAHGFSDIFEDIFGEMMGGRQRRSSGGRERGADLRYNMEISLEEAYSGKTAQIRVPTSITCDVCTGTGAKPGTSPKTCGTCQGTGRVRAAQGFFSIERTCPTCGGRGQTITDPCTKCHGQGRVVEERTLSVNIPAGIEDGTRIRLSGEGEAGLRGGPAGDLYIFLSVKPHEFYQRDGADLYCAVPISMTTATLGGKFDVTTLDGTKSRVTVPEGTQAGKQFRLKGKGMPVLRSSQMGDLYIQIQIETPQKLTKRQRELLQEFEQISSKENNPESAGFFSRMKGFFDTLSE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL61_HCMVA
Sequence: LWRGVLTTIEVSWRPTVDPERFRPHPTSPPHRPAHTPQPGGVRGADPGWAADGGRGVGDHAQGQQAATVRAEFFWGAAGEGSVTGQANAQDKADREPAARPRDPRSRLAAGPSRGGRGAQPEPPRGSRRETRKPSRSTPLPELLTGPPAPNLPGPIAVEPGRRPSPPPSTRPTYRRRRPTAATPSRKKKARRGPKASKAGREGELGGGSPVAHRGTSLGTGVRDPAPRGGRGRARTPGPVHSAAGGPGSRRRSPGAARDPGPEPGEERGGGGKPPLGSPRATDGNRDPGAGVPARPGRRMGGSSGGRGGTPGRGPERAAPGARPTAPDGAPGRWDGPADGPAPGLGRGGWGVGREAGGSGRSVRTAARPEPCRGLRRGAAGTPGFIGFQMPRLGGRSGNFPPPRPMPGTGLALPRCGRPVEKYRRMRTAHI
What are the official names of this protein?
Uncharacterized protein UL61.
Protein: Y1786_ARCFU
Sequence: MRSEVVNMLEYLYPLRTYLIVSGVEKPNVMTADWVVPLSFSPQLLGVAIGHSRYTHSLIKECGEFVVAVPTIELLKDVWKAGTLSGAKENKMEKLSLTLVESKKVKVPSIKECQANLECRVVKEVETGDHTLFVGEILHVTHGDAFKDGKPDINYKFVMHASFGKNFTTNSSERFEP
What are the official names of this protein?
Uncharacterized protein AF_1786.
What is the protein family that this protein belongs to?
Belongs to the flavoredoxin family.
Protein: RPOB_PASMU
Sequence: MVYSYTEKKRIRKDFGKRPQVLNVPYLLTIQLDSFDKFIQRDPEGQQGLEAAFRSVFPIVSNNGNTELQYVSYQLGEPVFDVRECQIRGTTYAAPLRVKLRLVSYDKDAAPGTIKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLYARIDRRRKLPATIILRALNYTTEQILDIFFDKVVFEISNNKLLMTLVPERLRGETATFDIEANGKVYVERGRRITARHIRALEKDQITQVEVPTEYIVGKVAAKDYVDLESGEIVCPANMEISLEMLAKLAQAGYKTIETLFTNDLDYGPYISETLRVDPSNDRLSALVEIYRMMRPGEPPTKEAAEGLFDNLFFSSDRYDLSAVGRMKFNRSLGIDEETGSGILSNDDIIGVMKKLIEIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRIGLVRVERAVKERLSLGDLDAVTPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRVCPIETPEGPNIGLINSLSVYARTNDYGFLETPYRKVVNGQVTEEIEYLSAIEEGKYVIAQANSNLDEELRFTDAFVTCRGEHGESGLYRPDEIHYMDVSTQQVVSVAAALIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGIEKAVAVDSGVTVIAKRGGMVQYVDASRIVVKVNEDETIPGEAGIDIYNLVKYTRSNQNTCINQIPCVSLGEPIGRGEVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSMLVSERVVQEDRFTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLVEELEILEAGLFTRVRSLLIAGGFDAKNLDKLDRTKWLEQSLSDEAQQNQLEQLAEQYEELRKEFERKLEVQRGKIIQGDDLAPGVLKVVKVYLAVKRQIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILETHLGLAAKGIGDKINAMIKQQQDVAKLREYMQKAYDLGHGSQKVDLSTFSDEEVMRLAQNLRKGLPLATPVFDGAHESEIKGLLELGGLPTSGQITLFDGRTGEKFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVGGTHQMDPGTPESFNVIMKEIRSLGINIDLDED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.