PharMolix/UniProtQA huggingface dataset:
Protein: MGT4A_XENTR
Sequence: MRLRNGTVATALVFITTFLSLSWYTAWQNGKEKLMAYQREFHALKERLRIAEHRTLQRSSELHAILDHFRRMIKEANGSRDALNHFSDETQKLIKDLTNRKALQVPNIYYHMPHLLNHDGSLQPAVQVGLGRTGVSVVMGIPTVKRRVKSYLKETLHSLIDKLSPEEKLDCVIIVFVGETDLEYVNSVVASLQKEFATEISSGLVEVISPPATYYPDLNNLKETFGDSKERVRWRTKQNLDYCFLMMYAQRKGIYYIQLEDDIVAKQNYFSTIKNFALQLSSEDWMILEFSQLGFIGKMFQAPDITLIVEFILMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKSNLRIRFRPSLFQHVGLHSSLAGKIQKLTDKDFLKPLLHKIHVNPPAEVSTSLKVYQGHTLEKTYLGEDFFWAITPVAGDYILFKFDKPVNVERYLFRSGNPEHPGDQLWNTTVEVLPYRKDIVELRSDTKDKRLSDGFFRIGKFEDGLAEGPVNSYLNPISALRLSVLQNSAVWVILNEIHIKRNPAD
What is the function of this protein?
Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (By similarity).  Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity).
What are the official names of this protein?
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa, GlcNAc-T IVa, GnT-IVa, N-acetylglucosaminyltransferase IVa, UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 54 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A soluble form]: Secreted.
Protein: ISPH_ACIBT
Sequence: MEIVLANPRGFCAGVDRAIAIVNRALECFNPPIYVRHEVVHNKFVVDDLRQRGAVFVDELDQVPDDSIVIFSAHGVSKAVQQEAERRGLKVFDATCPLVTKVHIEVTKYAREGTEAILIGHEGHPEVEGTMGQYDKLKGGDIYLVEDEADVAALEVRHPEKLAFVTQTTLSIDDTAKVIDALRAKFPNIQGPRKDDICYATQNRQDAVRDLAEKCDVVLVVGSPNSSNSNRLRELAERMGKAAYLVDNADQLEQSWFNDTCKIGVTAGASAPEILIKQVIQRLQDWGAQAPKELEGREENITFSLPKELRIHVTQA
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: PSBJ_DRIGR
Sequence: MADTTGRIPLWLIGTVTGIPVIGSIGIFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: FTSK_STAAS
Sequence: MAQAKKKSTAKKKTTSKKRTNSRKKKNDNPIRYVIAILVVVLMVLGVFQLGIIGRLIDSFFNYLFGYSRYLTYILVLLATGFITYSKRIPKTRRTAGSIVLQIALLFVSQLVFHFNSGIKAEREPVLSYVYQSYQHSHFPNFGGGVLGFYLLELSVPLISLFGVCIITILLLCSSVILLTNHQHREVAKVVLENIKAWFGSFNEKMSERNQEKQLKREEKARLKEEQKARQNEQPQIKDVSDFTEVPQERDIPIYGHTENESKSQSQPSRKKRVFDAENSSNNIVNHHQADQQEQLTEQTHNSVESENTIEEAGEVTNVSYVVPPLTLLNQPAKQKATSKAEVQRKGQVLENTLKDFGVNAKVTQIKIGPAVTQYEIQPAQGVKVSKIVNLHNDIALALAAKDVRIEAPIPGRSAVGIEVPNEKISLVSLKEVLDEKFPSNNKLEVGLGRDISGDPITVPLNEMPHLLVAGSTGSGKSVCINGIITSILLNAKPHEVKLMLIDPKMVELNVYNGIPHLLIPVVTNPHKAAQALEKIVAEMERRYDLFQHSSTRNIKGYNELIRKQNQELDEKQPELPYIVVIVDELADLMMVAGKEVENAIQRITQMARAAGIHLIVATQRPSVDVITGIIKNNIPSRIAFAVSSQTDSRTIIGTGGAEKLLGKGDMLYVGNGDSSQTRIQGAFLSDQEVQDVVNYVVEQQQANYVKEMEPDAPVDKSEMKSEDALYDEAYLFVVEQQKASTSLLQRQFRIGYNRASRLMDDLERNQVIGPQKGSKPRQVLIDLNNDEV
What is the function of this protein?
Essential cell division protein that coordinates cell division and chromosome segregation.  The N-terminus is involved in assembly of the cell-division machinery.  The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region.  Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
What are the official names of this protein?
DNA translocase FtsK.
What is the protein family that this protein belongs to?
Belongs to the FtsK/SpoIIIE/SftA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Located at the septum.
Protein: ECFA2_UREPA
Sequence: MQKLMDYFFKRKLKVPRPISNDISVRVKNLYAVYDEKQENQLVALNNISYDFKKNKIYFIIGNSGSGKSTLVTHFNGLMISRYGFVQVGDIVSGDHFDFERQLLGVIDSYDKKIINLLWRNQLDQWTFLVLFSNEVNIQQARILFEANFKQKPISLKFIKTKNNHELITNPYVRENTKIAVVRVDKNVILEINDKMNYEELQRFEFIKKEIKTNYHLSKKIKRFKELRRRVGFVFQFPEYQLFKDTIEKDIMFGPVNLGVKKSEAKKRAKFYLNKLGLGDDYLERSPFGLSGGQKRRVAIAGILAIQNDILVFDEPTAGLDPAGEHEMMQIILDAKANNKTVFVITHTMEHVLEVADEVIVMDEGEIIKTGTPYEIFFDQHIINSTSIQVPRVIAVINELIKKDLKYEILKQKQPRTIEELADAIIEFKKGEK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TSAC_XANOR
Sequence: MTHILTLDNAVATLTQGGVIAYPTEAVWGLGCDPRQEAAVLRLLEIKRRPVDKGVIVVTSRVDVLRDWVDIDALAPARRQDVLASWPGPHTWILPVTARAPRWVTGEHDGLAVRISAHPVVAALCAAWGAPLVSTSANLAGEPPARSRAALEPALLATIDGVVDGEVGALAQPTRIRDARSGQILRD
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR2_YEAST
Sequence: MLNILVLGNGAREHVLVTKLAQSPTVGKIYVAPGNGGTATMDPSRVINWDITPDVANFARLQSMAVEHKINLVVPGPELPLVNGITSVFHSVGIPVFGPSVKAAQLEASKAFSKRFMSKHNIPTASYDVFTNPEEAISFLQAHTDKAFVIKADGIAAGKGVIIPSSIDESVQAIKDIMVTKQFGEEAGKQVVIEQFLEGDEISLLTIVDGYSHFNLPVAQDHKRIFDGDKGLNTGGMGAYAPAPVATPSLLKTIDSQIVKPTIDGMRRDGMPFVGVLFTGMILVKDSKTNQLVPEVLEYNVRFGDPETQAVLSLLDDQTDLAQVFLAAAEHRLDSVNIGIDDTRSAVTVVVAAGGYPESYAKGDKITLDTDKLPPHTQIFQAGTKYDSATDSLLTNGGRVLSVTSTAQDLRTAVDTVYEAVKCVHFQNSYYRKDIAYRAFQNSESSKVAITYADSGVSVDNGNNLVQTIKEMVRSTRRPGADSDIGGFGGLFDLAQAGFRQNEDTLLVGATDGVGTKLIIAQETGIHNTVGIDLVAMNVNDLVVQGAEPLFFLDYFATGALDIQVASDFVSGVANGCIQSGCALVGGETSEMPGMYPPGHYDTNGTAVGAVLRQDILPKINEMAAGDVLLGLASSGVHSNGFSLVRKIIQHVALPWDAPCPWDESKTLGEGILEPTKIYVKQLLPSIRQRLLLGLAHITGGGLVENIPRAIPDHLQARVDMSTWEVPRVFKWFGQAGNVPHDDILRTFNMGVGMVLIVKRENVKAVCDSLTEEGEIIWELGSLQERPKDAPGCVIENGTKLY
What is the function of this protein?
Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
What are the official names of this protein?
Bifunctional purine biosynthetic protein ADE5,7.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_LACP3
Sequence: MALDVDGIIAQLKDASILELNDLVKSIEDEFGVKAAAPVAAGAAAGADAAAAKDTYDVELTEAGQEKVKVIKAVREITGLGLKDAKGMVDAAPKVIKEGLSEDDANKLKEQLEGVGATVTLK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: ENO1_LACJO
Sequence: MSVITDIHAREVLDSRGNPTVEAEVYTELGGFGRAIVPSGASTGEHEAVELRDGDKSRFLGQGVLTAVENVNGEIAKAVIGLDVTDQRLIDQTMIDLDGTPNKGRLGANAMLAVSLASARAAADELGLPLYEYLGGPNAHVLPTPMMNVINGGKHADNNVDIQEFMIMPVGAKSLHEAVRMGAETFHTLKSLLQERGESTAVGDEGGFAPNLKNNEEPFEILVEAIQRAGYKPGQDISIAFDCAASEFYNKDTKKYVTVADGREYTAEEWTSLMEDIVDKYPVISIEDPLDENDWEGWKVFTERLGDKVQIVGDDLFVTNTNYLEKGIKMGVANSILIKLNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDTTIADLVVATNAGQIKTGSMSRTDRIAKYNQLMRIEEALGSTAQYKGIHSFYNLHKQF
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase 1, 2-phospho-D-glycerate hydro-lyase 1, 2-phosphoglycerate dehydratase 1.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: COXX_DINSH
Sequence: MSDASFDRSMPLSGEGSFGDYFALLKPRVMSLVVFTALVGLLVAPVSLHPMVGFCAILFIAVGAGASGALNMWWDADIDVIMKRTAGRPVPAGKVQPGEALALGLGLSGLSVVMLALATNLLAAGLLAFTIFFYAVVYSMWLKRSTPQNIVIGGAAGAFPPMIGWVAATGSVSLEAVLMFALIFMWTPPHFWALALFMKSDYHDAGVPMLTVTHGRKSTRTHILVYTVLLVPVALGLALTPVAGPLYLATALVLNAIFLKGAWDIWRRDEAQAEADKYATEKRFFKFSLLYLALHFTALLAEAILTRSGLWTFGG
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y178_ALKPO
Sequence: MNKVNKINAYTCSSFQLHTIMKISFYVVERGFELAAFFTRRTIWIIISILLFLVAAYFILPVSLPLVAALLTALILTPAVNALQRKTKIKRNVAVMLVFTVFVVFIGLSGYYIATKAITQGTQIVENSPQYISDINRAWLNFQRNLEEKYENLPPELVQEINITVTNTLSDLRSNISDRNLIQDITSLISSIPGYLVTFLVYLIALFLFMLELPRLREKLYSYLSERTKEKVNFMTSRLSYVIWGFFKAQFLVSIIIFIVTLIGLLFIAPEVALLMAFIIWLIDFVPIIGSIVILAPWAIFQLIVGDVSTGSKLLILAAVLLIIRRTVEPKVMGKHIGLSPLATLIAMYLGLMLFGVIGFIIGPLLVIAFTSAKEAGIIKLNFKL
What are the official names of this protein?
Putative transport protein BpOF4_00890, ORF2.
What is the protein family that this protein belongs to?
Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: WAKLL_ARATH
Sequence: MRGNKNYYFLSLLYFLSLPILHFSSCTHKCGDIQIPFPFGIGEIGCYLDEWYQVECRPSATSGKVFPFLPKINMEVVNISLPGTNDDIFYTYPSFSSIRVKSPVASMGCSTDGNDSGLTLNFTETPFFFGDQNNLVAVGCNNKASLTNVEPTMVGCESTCTTSNNSRSIPFFNKVGCSGSVDSVTRDLLPKNYIPVCSTTKIQDDTLICNGEGCCQAKAPVGSQQLIGVTITNSTNGNLTKGGGCKVAFLTDEVYTLSNATDPEQFFSKGVTVSLGWFIQTKNHSFLQSLDCQNRGELDKGKKRTRQCTCDNHIASGMGYASCACASGYKGNPYVSDDCQDINECTEYKNPCGDTRILYRNTCINTSGGHRCIDYHIPEVMLGLGAGFFVLIVGGGIWWWRKLLRKRRMTNRKRKFFKRNGGLLLQQQLNTTQGRVEKTKLFSSRELEKATDNFNDNRVIGQGGQGTVYKGMLVDGRSVAVKKSNVVDEDKLQEFINEVIILSQINHRHVVKLLGCCLETEVPILVYEFIPNGNLFQHLHEEFDDYTALWGVRMRIAVDISGAFSYLHTAACSPIYHRDIKSTNILLDEKYRAKVSDFGTSRSVSIDHTHWTTVISGTVGYVDPEYYGSSHFTEKSDVYSFGVVLVELITGEKPVITLSETQEITGLADYFRLAMRENRLFEIIDARIRNDCKLEQVIAVANLALRCLKKTGKTRPDMREVSTALERICSAPEDFQVQIQIDEEDETTKLFRGYSGSTEIARSM
What is the function of this protein?
Putative serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component.
What are the official names of this protein?
Putative wall-associated receptor kinase-like 13.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: YBAB_SALPC
Sequence: MFGKGGLGNLMKQAQQMQEKMQKMQEEIAQLEVTGESGAGLVKVTINGAHNCRRVEIDPSLLEDDKEMLEDLVAAAFNDAARRIEETQKEKMASVSSGMQLPPGFKMPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein YbaB.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: MURA_HAES1
Sequence: MQKFRVYGQSRLNGEVNISGAKNAALPILFAAILAEEPVKLTNVPELKDIDTTLKILQQLGVVTYRDEQGAVHLDASNINHFVAPYELVKTMRASIWALAPLVSRFKQGQVSLPGGCSIGARPVDLHISGLERLGAKIVLEEGYVKAFVDGQLIGKRIVIEKVSVGATLSIMIAATLAKGITVIENAAREPEITDTAVFLNKMGAKISGAGSDIITIEGVERLGGCEHSIVPDRIETGTFLVAAAISGGRIICKNTKASTLDAVIDKLRDAGAKIEVTENTITLDMQGNRPKAVNIRTEPYPGFPTDMQAQFTLLNMVAEGSSKITETIFENRFMHIPELIRMGGKAEIEGNTAFCHGVEYLSGAEVMATDLRASISLVLAGCIATGETIVDRIYHIDRGYEHIEKKLRGLGAKIERFTEKIVD
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HESB1_TRIV2
Sequence: MTVTLTEKAEFRLRAFLRGSAKDANETTKGIRISVKDGGCSGYEYLMDVTSQPQPDDLVSQQGSVLVYVDAKSAPLLEGIVIDFVEGLVESGFKFTNPNATSTCGCGKSFKAGDCSPEGVPCS
What is the function of this protein?
May be required for efficient nitrogen fixation.
What are the official names of this protein?
Protein HesB, heterocyst.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: MYPH_ECHGR
Sequence: MSNVPPPSGLSYQVKKKLEGKRDKDQENEALEWIEALTGLKLDRSKLYEDILKDGTVLCKLMNSIKPGCIKKINENATMPFKIMENISAFLEAMKGYGVPVADLFQTVDLFEKKDIAQVTRTLFALGRTCQTHPEYSGPVLGPKLATENKREFTEQQLREGQNVVSLQYGSNKGASQAGINMGKQRMIMD
What are the official names of this protein?
Myophilin.
What is the protein family that this protein belongs to?
Belongs to the calponin family.
Protein: RL11_BARBK
Sequence: MAKKNAGQLKLQVPAGAATPSPPIGPALGQRGINIMEFCKAFNAATQEMEKGAPIPVVITYYQDKSFTFSLKTPPVSFFLKKEANLKSGSKEPGKVFVGTISRDKICSIAEAKMKDLNANNIEAAMRMIEGSARSMGLEVVG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SNX9_HUMAN
Sequence: MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEILPSDGKDQFSCGNSVADQAFLDSLSASTAQASSSAASNNHQVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMSYALQAEMNHFHSNRIYDYNSVIRLYLEQQVQFYETIAEKLRQALSRFPVM
What is the function of this protein?
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis.  Required for efficient progress through mitosis and cytokinesis.  Required for normal formation of the cleavage furrow at the end of mitosis.  Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis.  Plays a role in macropinocytosis.  Promotes internalization of TNFR.  Promotes degradation of EGFR after EGF signaling.  Stimulates the GTPase activity of DNM1.  Promotes DNM1 oligomerization.  Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton.  Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation.  Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
What are the official names of this protein?
Sorting nexin-9, SH3 and PX domain-containing protein 1, Protein SDP1, SH3 and PX domain-containing protein 3A.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin- coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
Protein: G6PI_BORA1
Sequence: MPQSLPFSPAWLAFEEAVRGASHRGDHLRIIEGGGLSVDLTAQAYSPQLEAAGLALCEQQGFALARRQLFEGGEANWTEHRPAWHTALRAALPPPSVAKDILNERERLRRFVDEADARGAYKYVLHLGIGGSDWGPRLVARALRHQGLKREVRFASNVDSHAVADAMHQLDPHETLVIVASKSFTTTEPLANAEVAIHWLQNAGVADPIKQVVAITANVDAALDFGISPQHVFRFWDWVGGRYSLWSAIGLPIALAMGNNTFDELLAGAAAMDEHFLRAPLAANAPVQMALAGLANRSVMGFNSLAIAPYDSRLAHLVPWAQQLEMESLGKVATRDGSPAGVPTGPVVWGMTGTDCQHTFFQWLHQDTTGAPVDFIVCEHADHTYDHHHRLLIANCLAQRAALLRGKSFEDALAETCARVDDPSEARILAEHLVHPGRRPSTLIVLPRMTAHNLGALLALYEHKVFTQGVLWGINPFDQWGVEFGKALARGIIGELDKPSGMASADPSTRYWVDLLSRRS
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_CHLMU
Sequence: MIHWEQSRTLLSFPQVGLHLSWYGIFFSLGIFLSSFAGIRLATVLCKDPNMRKELKTGLENFALGALLVIVIGARAFYVLFYGGSFYFENPSEIIKIWKGGLSSHGAIIALVIWSAAFSRFHIRRLPMLSVTYICDICGAVFGVAALLIRVGNFMNQEILGTPTSMPWGVVFANDSSLIARHPVQLYEGVSYLLLSLVLYWLCYRGSIRLGSGYSAAGALIGVASIRFCAEFFKTHQGSWLGEESLLTIGQWLSIPMVFLGIGILWIASKKREP
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ERB1_CRYNJ
Sequence: MAPQPLKVGTSKLSKMVKSAPKTAGKAKKRAVEQVSEESDEEFGDQGSGIDMSDDEEEVDGDDEEDEDEAFPEFDSELEDNDQEEASDEEQDEQDTSDESEIVEEDSDSESGYNTSDIERMYASDDDLSSEENKDLPVDEKLSRLIAKNTVKPDDSIGTDDKISRAKEGVGRLVPSKHVKGSFVREYDEYEAGYGSESSTEDNPNTVGNIPMEWYDDLPHIGYDVNGRKIFRPLQGDELDKFLANVEDPSAWTSAEDKLLQQNVQLSDKELDIIRRLERAENPDADFDPYQPTIEWFTGEGKERVMPLSAAPEPKRRFVPSKWEHKKIMKIVKAIREGRIIPNKPSAEKPRFYPIWSDADQHNPHVMYMPAPQLPPPKTAESYNPPEEYLPTEEEKAEWEAMDKEDRKTDFLPEKYDALRKVPGYKNLVQEKFERCLDLYLAPRTRRVKLNIDPDSLIPKLPAPKELKPFPIASTVQYRHPGDTRVRSVSTSPDGQWIASGSEDGVVRVWDLGNGREVWRWDLHAGPIQYVEWSPSREESLLVALVAGKIAVLSPLALVAPHIAAQTLTHSNTAFATSSATTKQGAGNEVKGIESVKWTRPSERERERGVLVYVEVPGTPKQVTWHRKGDYFATVASDAANKSVLIHQLSRHGSQSPFRKTPGTIQRVAFHPSKPHFFAATQRYIRLYDLAAQKLIRTLQSGVKWISSMDVHSGGDNLIIGSYDKKLAWFDMDLSAKPYKTLRYHNRALRSVAYHPTLPLFASASDDGTVHIFHCTVYTDLMQNPLIVPLKILRGHKVIDGIGVLDLRWVPGKPWLVSSGADGEVRLWCS
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein ERB1, Eukaryotic ribosome biogenesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: MRE11_PYRAB
Sequence: MGIKFAHLADVHLGYEQFNRSQRAEEFAKAFEDAIKICVDEKVDFIVIAGDLFNSSRPSPGTIKTAVKILQIPRDNNIPVFAIEGNHDRTQRGPSILHLLEDLGLLYVLGVRDEKVENEYLTSEKTKAGWLVKGMYKDVEIHGMKYMSAAWFEGNIELFKSMFRPEGDAILVLHQGVREITENNYPNYSSELSLSDLPKGYLYYALGHIHKRFELTYDDAPVVYPGSLERWDFGDYSLKLTWNGFQFKEEVGVDKGFYIVEDFKPRFIRINARDFIDVHIKGHSENEIKKAVKLAVPKIPRNSYVRFNIRWKRPVDVDWIKSIVNAEYVRVNPIIIKEERGPDGKDLDVKKFFTELEWKIIELASEKEYEYYLNQIIDLLASEEGKVEAKIDAKREEKKFVRPKNPGDIMAWVKG
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
What are the official names of this protein?
DNA double-strand break repair protein Mre11.
What is the protein family that this protein belongs to?
Belongs to the MRE11/RAD32 family.
Protein: Y1492_PROMT
Sequence: MYCIELTIKLSPMPLVVQRKEHGEAKRLYSDVVGSIENGNPRLLELTCEKVEDKRITVLVSEITAVQIYEKTSSSTSKRPGFSLQN
What are the official names of this protein?
UPF0367 protein PMN2A_1492.
What is the protein family that this protein belongs to?
Belongs to the UPF0367 family.
Protein: ATPH_ORYNI
Sequence: MNPLIAAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RIMO_SHESM
Sequence: MTVETFNPKQTTTLETPAKTLEAASADSTATGNRIGFVSLGCPKNLVDSERILTQLRIDGYEVTNSYDNADLVIVNTCGFIDAAVEESLDAVREALEENGKVIVTGCLGAKENQIREVHPDVLEITGPHSYEAVLKHVHKYVPKPEHNPFTSLIPQTGVKLTPKHYAYLKISEGCDNRCTFCIIPALRGDLDSRPAGSVLDEAKRLVESGVQEILVVSQDTSAYGKDKGGRTDFWNGMPVKQDITSLARQLGKMGAWVRLHYIYPYPWVDDLIPLMAEGLILPYLDIPMQHASPRILKMMKRPGRVDRQLEAIQRWREICPDLVIRSTFIVGFPGETEEDFEMLLDFLREARLDRVGCFKYSEVEGAVANTIAELISEDVKEDRYHRFMEVQAEISAERLARFVGRTMDILIDDVDEEGAIGRSFADAPEIDGMVFINGETELEPGMLVRAVITHSDEHDLWAELVDADAEDDIEA
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.