PharMolix/UniProtQA huggingface dataset:
Protein: TVB62_HUMAN
Sequence: MSLGLLCCGAFSLLWAGPVNAGVTQTPKFRVLKTGQSMTLLCAQDMNHEYMYWYRQDPGMGLRLIHYSVGEGTTAKGEVPDGYNVSRLKKQNFLLGLESAAPSQTSVYFCASSY
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 6-2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: RL5_PROMS
Sequence: MTLKNRYKESIRPKLLKDLGLKNIHQVPKVVKVNVNRGLGEAASNSKALEASLNEMATITGQKALVTRAKKAIAGFKIREGMPIGCTVTLRGDRMYSFLERFINLALPRIRDFRGVNPKSFDGRGNYTVGVKEQLIFPEISFDKIDSIRGMDITIVTSAKSDQEGKALLQELGMPFSKN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: GSA_SHEB9
Sequence: MTRSEALFEQAKKTIPGGVNSPVRAFNGVGGSPLFIEKANGAYIYDADGKAYIDYVGSWGPMILGHNHPKIRAAVLAAVENGLSFGAPTELEVQMAEKVISMVPSIEQVRMVSSGTEATMSAIRLARGFTNRDKILKFEGCYHGHADCLLVKAGSGALTLGQPSSPGIPEDFAKHTLTAVYNDLDSVRTLFEQYPTEISCIIIEPVAGNMNCIPPIPGFLQGLRDICDEFGALMIIDEVMTGFRVSQSGAQGYYGVTPDLTTLGKVIGGGMPVGAFGGRKDVMQFIAPTGPVYQAGTLSGNPIAMSAGLAQMEALCEEGLYEELSAKTKRIAEGFKAAADKHGIPMAINYVGGMFGFFFTEQPEITRFDQVTQCNIEQFRIFYHGMLDEGVYLAPSAYEAGFLSMAHGEEEMRLTLEAADRVLASMKAAS
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKA_CERS1
Sequence: MNFGRVNPAQTLDAQGITGLGEVHYNLIEPALVEAAVTRGEGRLGRGGAFLCSTGAFTGRSPKDKFVVRTPSVEDTIWWENNAPMDPAAFDRLHADMLEHMKGRTYFVQDLFAGADPELRLDVRMVTELAWHGLFIRHMLRRPERAELDSFVPDWTVINCPSFKADPERHGCRTDTVIVLNFERKLILIANTEYAGENKKSVFTLLNYILPGKGVMAMHCSANHALGDTDDAAVFFGLSGTGKTTLSADPSRTLIGDDEHGWSDRGTFNFEGGCYAKTINLSAEAEPEIYATTSKFATVVENMVYDEETLELDFNDDSLTANTRCAYPLDYISNASESGLGGHPKNVIMLTCDAFGVLPPIARLTPAQAMYHFLSGFTSKVAGTERGVTEPQPTFSTCFGAPFMPRRPEVYGKLLQEKIAKHGATCWLVNTGWTGGAYGTGKRMPIKATRALLTAALDGSLSGVQFRRDPNFGFEVPVDLHGVDAKLLDPRSTWADPAAYDQQAKKLVEMFANNFAQYVPFIDADVKAAAIG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARF_GIAIN
Sequence: MGQGASKIFGKLFSKKEVRILMVGLDAAGKTTILYKLMLGEVVTTVPTIGFNVETVEYKNINFTVWDVGGQDSIRPLWRHYYQNTDALIYVIDSADLEPKRIEDAKNELHTLLGEDELRDAALLVFANKQDLPKAMSTTDLTERLGLQELKKRDWYIQPTCARSGDGLYQGLDWLSDYIFDKKNKKKGKKR
What is the function of this protein?
GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
What are the official names of this protein?
ADP-ribosylation factor.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Golgi apparatus.
Protein: SBMC_YERE8
Sequence: MAFKIIEKQPQQIVSIRVVGPYHETIPKGFDQLSSLYTQYQIPGKDWLVLYWDNPETNPPAELRADVSLSVADDYVLPPELSDHLQLQVIPAGLYAVYHTRVSDDDYAKAWGELYNQHLPQSGYRPTEGACYEVYLNDGRADGYFDIDIYQSVEKDQ
What is the function of this protein?
Inhibits the supercoiling activity of DNA gyrase.  Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase.  It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
What are the official names of this protein?
DNA gyrase inhibitor.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_PSEAE
Sequence: MSIHSASPIIRRKSRKIWVGNVPVGGDAPIAVQSMTNTETCDVAATVAQIRRLEDAGADIVRVSVPDMDAAEAFGKIKQQVNVPLVADIHFDYRIALRVAELGVDCLRINPGNIGREDRVKAVVDAARERNIPIRIGVNAGSLEKDLQKKYGEPTPEALLESAMRHVDHLDKLDFQNFKVSVKASDVFMAVAAYRLLARQIEQPLHLGITEAGGLRSGTVKSAVGLGMLLAEGIGDTIRISLAADPVEEIKVGFDILKSLHLRSRGINFIACPSCSRQNFDVVKTMNELEGRLEDLLVPMDVAVIGCVVNGPGEAKEAHVGLTGGTPNLVYIDGKPSQKLTNDNLVDELERLIRQKAAEKAEADASLIARG
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: HTRAL_STAAN
Sequence: MDIGKKHVIPKSQYRRKRREFFHNEDREENLNQHQDKQNIDNTTSKKADKQIHKDSIDKHERFKNSLSSHLEQRNRDVNENKAEESKSNQDSKSAYNRDHYLTDDVSKKQNSLDSVDQDTEKSKYYEQNSEATLSTKSTDKVESTEMRKLSSDKNKVGHEEQHVLSKPSEHDKETRIDSESSRTDSDSSMQTEKIKKDSSDGNKSSNLKSEVISDKSNTVPKLSESDDEVNNQKPLTLPEEQKLKRQQSQNEQTKTYTYGDSEQNDKSNHENDLSHHTPSISDDKDNVMRENHIVDDNPDNDINTLSLSKIDDDRKLDEKIHVEDKHKQNADSSETVGYQSQSTASHRSTEKRNISINDHDKLNGQKTNTKTSANNNQKKATSKLNKGRATNNNYSDILKKFWMMYWPKLVILMGIIILIVILNAIFNNVNKNDRMNDNNDADAQKYTTTMKNANNTVKSVVTVENETSKDSSLPKDKASQDEVGSGVVYKKSGDTLYIVTNAHVVGDKENQKITFSNNKSVVGKVLGKDKWSDLAVVKATSSDSSVKEIAIGDSNNLVLGEPILVVGNPLGVDFKGTVTEGIISGLNRNVPIDFDKDNKYDMLMKAFQIDASVNPGNSGGAVVNREGKLIGVVAAKISMPNVENMSFAIPVNEVQKIVKDLETKGKIDYPDVGVKMKNIASLNSFERQAVKLPGKVKNGVVVDQVDNNGLADQSGLKKGDVITELDGKLLEDDLRFRQIIFSHKDDLKSITAKIYRDGKEKEINIKLK
What are the official names of this protein?
Serine protease HtrA-like.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: SPK1_CAEBR
Sequence: MLSILHSLSWMAHWINPTATIAPSTPPQAGEKNANVKNGTVQTNGVNHTERLAGRAPNLLHPAIDYPGITSYEAGGSLILTDIFPTVLFMFVVLFCRWFNGFAPRQERFQRLEYEAILRRRRFRVQSEESEELEDHEAYSETDICTQLIASSANVACNINVDLVNQNRFYFFVKQNNEDETAVPSDVPPPETSIKNEDTEVNLVFASAEDNGYISSTFEVSETSLMVTSEVYEVEKVSVNEDQSSRPVNVIVNESDDEQSLRSQDGSRCSDEAMNSCMSASEDEDVESQEDSYHVNDATEDSVSSIKTQEDEPIEEELASCHSDEDDHQNEVLGDEEASKYDNLPVEMRSAKEGDESEGTIDSSVSSSTSSTPDDDEDDSATSYDSDDIEIQMFEYDLGTVCASASISIPRPSIIPKKNKKAEVNANEERMDDVSVSPGRSDSPGGGGGHSDSFQDPLDPGEQLGSDDEEQEDPRDYKRGGYHPVNIGDVFNSRYHVIRKLGWGHFSTVWLAWDTQEKRFTAMKIVKSAEHYTEAALDEIKLLLSVRGADPEDTGCHKVVQLLDEFTVTGINGQHVAMVFEVLGCNLLKLIIRSNYRGLHLEQVRKICKQILEALRYMHEKCGIIHTDIKPENVLITMSREEIKIMAQHAVVARKMNMKMSGSAVSTAPDHLVKMAQENMTKNKKKKMKKKAKKQREKLEAELAGLEGLKMDANGLQEAYNNAPQNGIRMRPPSLLFNGPIPQLLQGSSCVNTPSSPRSVPPPPALYPQAGGVCNQTYHLSQVILNEQVELESFNTSQVEDVNIEDAVNGNGNGTNNKIELKSPDRFDRTTLTPFSDPESKIGELASPSSEFLSSPMSMLPPGGVLPAPPVGPNIADPYCDIDVKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGQISPSIYKKGKHWREFFHKNGNLLHIHNLKPWSLYEVLRQKYEWSHEDAQQFESFLRPMLDFDQEKRATANDALKHPFLLPFGGKAPRDPEVLQRLYPDGQVPEALDGNQEVYRDENDSNSASERSANRSAGSDDEEEFHMDRPGPSGVINEPADVSEIESFQLNLQ
What is the function of this protein?
Required for embryogenesis and germline development in both adult hermaphrodites and males.  SR-protein kinase (SRPK) that binds directly to and phosphorylates RS domains (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase spk-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: LTOR5_XENTR
Sequence: MEAALEQHLEDTMKNPSIVGVLCTDSQGLSLGCCGSLSDKHAGVISILPQYAAKLTSDPTDVPVVCLESDNGIVMIQKHDHLTVAVHKVTS
What is the function of this protein?
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids.  As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids (By similarity).
What are the official names of this protein?
Ragulator complex protein LAMTOR5, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR5 family.
What are the subcellular locations of this protein?
Cytoplasm. Lysosome.
Protein: LUXS_CLOAB
Sequence: MEKIASFTVNHLTLQPGVYVSRKDKFGDVVITTFDIRMTSPNEEPVMNTAEVHTIEHLGATFLRNHGTYAEKTVYFGPMGCRTGFYLILQGDYTSNDIVPLLREMYKFIADFKGEVPGAAARDCGNYLDMNLPMANYWGKKFSALLDNISEDRLNYPE
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) (By similarity).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: YBL1_STRCI
Sequence: MVATAEGEPGLTDALARLAGSGRADMPDLELLPGSYDLPGARLLDVVEVMDRIRLACPWSARRTHHDLVKYGVEEMYELVDAIEAGDRGELREELGDVLLQVVFHARIAQDDADEPFAIDDVAGTLVTKLVHRHPHVFGDDVAETAADVEAHWRRRKAEEKHERTSVTEGVPLGQPALALAAKLASRARAAGIAVRPEECGTGVGYRLLEMAVGAEADGVDPESALRAAAHVYRDAIRAAEG
What are the official names of this protein?
Uncharacterized 26.1 kDa protein in blaB 3'region.
What is the protein family that this protein belongs to?
To E.coli MazG and to plasmid pIP1100 erythromycin esterase.
Protein: LPLT_SALHS
Sequence: MSESVRTNTSIWSKGMLSVIVAQFLSAFGDNALLFATLALLKTQFYPDWSQPVLQMVFVGAYILFAPFVGQIADSFAKGRVMMVANGLKLAGAAGICLGVNPFVGYTLVGIGAAAYSPAKYGILGELTTGDKLVKANGLMEASTIAAILLGSVAGGVLADWHVIAALVACALAYAGAVAANLFIPKLVAARPGQSWRLSAMTRSFFSACVVLWRNGETRFSLVGTGLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAVGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVAIFSLQHALLPAYALLLLIGMLGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSAMLLMLGLYSLAVLVGVPAVAIGIGFGVLFALAIAALWIWQRRQASY
What is the function of this protein?
Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
What are the official names of this protein?
Lysophospholipid transporter LplT.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCRL2_PIG
Sequence: MANYTSAPEDDYDVFIEDDLSNDERELCSPYDPQALLAQLVPYLFITVFLVGLLDNILVVLIMVKYKGLKQVENIYLLNLAVCNLCFLCTLPFWVHMAWHEGDPGEPLCKILLVLYSVGLFSEAFFNVLLTVQRYQKFFQMRGFFSATRMVAGSIFPSALVWVIAVLVMLPELAFYKPQMENQKYKCFFGRPLFLPADETFWKHFLTLKMNILGFLLPLFVFVFCYVRMRRTLKFGERGYDLFKLVFTIMVVFLLMWGPYNIALFLSAFNEHFSLHGCESSHNLDRSTLITKIIATTHCCVNPLLYVFFDEAFRKHLYHFCHLCNDTAPQPTEEPAQGTSREEPCLSTKM
What is the function of this protein?
Receptor for CCL19 and chemerin/RARRES2.  Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor.  Plays a critical role for the development of Th2 responses (By similarity).
What are the official names of this protein?
Chemokine C-C motif receptor-like 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATPE_DRIGR
Sequence: MTLNLCVLTPNRIIWDSEVKEIILSTNSGQIGVLPNHAPIATAVDIGILRIRLNDQWLTMALMGGFARIGNNEITILVNDAERGSDIDPQEAQRTLEIAEASLSRAEGKRQEIEANLALRRARTRVEAINVISY
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, chloroplastic, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: BIOF_SALHS
Sequence: MSWQQRVDDALTARRVTDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAATRFGVGSGGSGHISGYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRLLQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGVSGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGGERREKLAALVQRFRAGVNASRFTLLNAHSAIQPLIVGDNSRALRLAEALRQQGCWATAIRPPTVPVGTARLRLTLTQAHEACDIDRLLEVLHGAGE
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: RL18A_PYRHO
Sequence: MEVKVFRVSGYFEKDGRKFKFTKEYRALKEEHVKELVYSDIGSRHKVKRRKIFIKEIREIKPEEAEDIVVRRLSLEL
What are the official names of this protein?
50S ribosomal protein L18Ae, 50S ribosomal protein L20e, 50S ribosomal protein LX.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL20 family.
Protein: SEY1_CRYHO
Sequence: MRQIIDYDCNFKEEVGEVLKDISTSQNTLGFNVISILGCQSTGKSTLLNALFDTHFKVLDKLTSGYCQTTKGLWLGCGTESFNSPILIWDVEGTDSLERGEDRATFENRAALFSLAVSDCMILNIPLMNLTTYSSSNFGLLKTILNSWFSLKLDQNGITRGNIRKTTLLFAVRDITINDNDEMLGRKVVQILDLLWRQVAESQNSLGNQIPASFSDIFEVKVYGIPSLPNDYDGFKQVVAAIRYDLTTSILPKDYTRRIPLEGLEMYCKTVWKCIVDCQELNIPSQIKLVSRFRCEQAKDDILDGYKKSIKDLQKKMEKREFGFNEFSDCTLLVLENSLAAYFEVASKYDHEMSTNSSISLLVFIFHEFQNAVNSRMSLERQDLRQYTNILDYYKKGIEDHQVQYDKENNEESHYVSFDSSSWVNKELLKFDSLSLKWKTEFPSVISRQHLISPIKEKCIPDILNEISLSSQGKEVFLATYNTQEQRKLLSETLEIHSKKIYEKLVEEFFESLIKDILKEISPLLGDHFLSDPKLKLDDFWELTGSSIVNIHRLLVSKYEQQWITLFKNSNMNEFTSSGLEEEIALQLVLKFIQLIQQQSKYFHINIVDRFKNEFELDQDGVPRQWIGEDAKTMKELFIKAKNNSLQITNVFYPRKDQLIPLSGRFSNLFDKIIENSEDLSGIIALNKGHGNGKFLDSVPLISESNLKEIESKASQEITSIFSKAQLIQSTGRQPQNIPWWIYLLIIILGFDEITYVLTSPVLVTLLLLLASFIYSYLTGNFSSFCNYSQQFVIISTKILHYISGAIHSSLDNRK
What is the function of this protein?
Probable GTP-binding protein that may be involved in cell development.
What are the official names of this protein?
Protein SEY1 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ATPB_PROM1
Sequence: MAASATATVGTKGIVRQVIGPVLDVEFPAGKLPSILNALRIEGKNPAGQDVALTAEVQQLLGDHRVRAVAMSGTDGLVRGMEALDTGAPISVPVGEATLGRIFNVLGEPVDEQGDLKNVTTSPIHRSAPSLTDLETKPKVFETGIKVIDLLAPYRQGGKVGLFGGAGVGKTVLIQELINNIAKEHGGVSVFGGVGERTREGNDLYEEFKESGVINSEDLTKSKVALCFGQMNEPPGARMRVGLSALTMAEHFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGELQERITSTLEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLARALAAKGIYPAVDPLDSTSTMLQPSVVGDEHYRTARAVQSTLQRYKELQDIIAILGLDELSEEDRKTVDRARKIEKFLSQPFFVAEIFTGMSGKYVKLEDTIKGFNMILSGELDQLPEQAFYLVGSIDEVKAKAEKLASEAKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: MSX1_MACMU
Sequence: MAPAADMTSLPLGVKVEDSAFGKPAGGGAGQAPSAAAATAAAMGADEEGAKPKVSPSLLPFSVEALMADHRKPGAKESALAPSEGAQAAGGPAQPLGVPPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKPERTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYGASGPFQRAALPVAPVGLYTAHVGYSMYHLT
What is the function of this protein?
Acts as a transcriptional repressor.  May play a role in limb-pattern formation.  Acts in cranofacial development and specifically in odontogenesis (By similarity).
What are the official names of this protein?
Homeobox protein MSX-1, Msh homeobox 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the Msh homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AKP8L_HUMAN
Sequence: MSYTGFVQGSETTLQSTYSDTSAQPTCDYGYGTWNSGTNRGYEGYGYGYGYGQDNTTNYGYGMATSHSWEMPSSDTNANTSASGSASADSVLSRINQRLDMVPHLETDMMQGGVYGSGGERYDSYESCDSRAVLSERDLYRSGYDYSELDPEMEMAYEGQYDAYRDQFRMRGNDTFGPRAQGWARDARSGRPMASGYGRMWEDPMGARGQCMSGASRLPSLFSQNIIPEYGMFQGMRGGGAFPGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKKKKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEATEGLEGTEAVEKGSRVDGEDEEGKEDGREEGKEDPEKGALTTQDENGQTKRKLQAGKKSQDKQKKRQRDRMVERIQFVCSLCKYRTFYEDEMASHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIQQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDSPEEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPEPAPGAVSPPPPPPPEEEEEGAVPLLGGALQRQIRGIPGLDVEDDEEGGGGAP
What is the function of this protein?
(Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.
What are the official names of this protein?
A-kinase anchor protein 8-like, AKAP8-like protein, Helicase A-binding protein 95, HAP95, Homologous to AKAP95 protein, HA95, Neighbor of A-kinase-anchoring protein 95, Neighbor of AKAP95.
What is the protein family that this protein belongs to?
Belongs to the AKAP95 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus matrix. Nucleus speckle. Nucleus, PML body. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601).
Protein: NEUA_STRA3
Sequence: MKPICIIPARSGSKGLPDKNMLFLAGKPMIFHTIDAAIESGMFDKKDIFVSTDSELYREICLERGISVVMRKPELSTDQATSYDMLKDFLSDYEDNQEFVLLQVTSPLRKSWHIKEAMEYYSSHDVDNVVSFSEVEKHPGLFTTLSDKGYAIDMVGADKGYRRQDLQPLYYPNGAIFISNKETYLREKSFFTSRTYAYQMAKEFSLDVDTRDDFIHVIGHLFFDYAIREKENKVFYKEGYSRLFNREASKIILGDSKTISISLENYHNYSQGGVTLATMLENLPNFLTANVTEAFVSIGVNDLITGYSVEEIFSNFQKLYSLLAENKIKMRFTTIAYTLFRETVNNADIEKINQWLTEFCYQNQIPLLDINRFLSKDGNLNYHLTSDGLHFTQEANDLLQSQYQLFVDEVKTL
What is the function of this protein?
Catalyzes the formation of CMP-N-acetylneuraminic acid (CMP-NeuNAc), which is essential for the formation of the capsule.
What are the official names of this protein?
N-acylneuraminate cytidylyltransferase, CMP-N-acetylneuraminic acid synthase, CMP-NeuNAc synthase, CMP-sialic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CMP-NeuNAc synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURT_FRATW
Sequence: MNISNIKIMLLGSGELGKEFIIAAQRLGIHTIVVDRYKNAPAMQVAHESYVIDMLNSDALEQLILAKNPTYIVPEIEAINTDSLVKLEAHNFNIIPCAKATKLTMDRQGIRALAAQQLNLQTSKFAFANSEQEYLDVIQSIGLPFVIKPVMSSSGKGQSIVKEHNEIKKAWDYAQNGSRGHAKGVIVEQFIDFDYEITLLTVRHKDGTSFCDPIGHIQKDGDYRFSWQPHTMPDTALAKSQEIAKEITDALGGYGVFGVELFIKGDEVFFNEVSPRPHDTGMVTLISQNINEFELHLRAIVGLPIPDIQTLQPSASAAILLEGDTANASICGIDKALADANVDIRIFGKKEIHGKRRMGVVLAKAQNTHIALETSKQALAHIHLTK
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: PDXT_MYCLE
Sequence: MSFPRVGVLALQGDTREHLTALREAGADSMPVRRRGELDEVDALVIPGGESTTISHLLLDCELLEPLRARLADGLPAYGACTGMILLASEILDAGVCGREALPLGAIDITVRRNAFGRQVDSFEGDIGFAGLVDPVRAVFIRAPWVERAGDGVQVLAQAAGHAVAVRQGSMLATAFHPEMTSDRRIHQLFVDIVNGIA
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.