PharMolix/UniProtQA huggingface dataset:
Protein: CTR_PHACE
Sequence: MKVALVVLALFGVSLAASIDNIEIPPSKNIYVEPINQPEVDPSLEIVNGQEVVPHSIPYQIFLVASAGETSWTCGGSLITKRYVLTAAHCIQGAKSVHVTLGAHNLAKHEASKVTVNGRSWVIHEKYDSTNIDNDIGVIQLERNLTLTRSIQLARLPSLRDVGINLEGRTATVSGWGLTNGIFQTTTDVLRANNTIISNKECNDVFKIVQPTEVCLSIAGGRSACSGDSGGPLVIDNVQHGIVSYGSSYCRSTPSVFTRVSSYLNWLQTHSEWRAQ
What is the function of this protein?
Serine protease with chymotryptic and collagenolytic activities.
What are the official names of this protein?
Chymotrypsin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: PFKA_BREBN
Sequence: MRKLAVLTSGGDSPGMNAAVRAAVRRAHFHEVQMFGVYHGYEGLMRGDIKEMSLGSVGDIIQRGGTILYSARSEAFKTEAGQQRAVEQLRAHEIEGLIVIGGDGSFRGAQKLTEKGFPTIGVPGTIDNDIPCTDFTIGFDTALNTVVEAIDKIRDTATSHERTYIIEVMGRDAGDLALWAGLAAGAESIMIPEASQDMDDIIERLHAGQRRGKKHSIIIVAEGVGSAASYAEAITKETGWETRVTVLGHIQRGGSPTAMDRMLASRMGAAAVDLLLEGKQDRMVGVQNNQIVDVDFQEALAKKHQLDLSIYQLARTLSI
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase, ATP-PFK, Phosphofructokinase, Phosphohexokinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MISSL_MACFA
Sequence: MSDEFSLADALPEHSPAKTSAVSNTKPGQPPQGWPGSSPWNNPSAPPSVPSGLPPSATPSTVPFGPAPTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPTGSYPTPGLYPTPSNPFQVPSGPSGAPPMPGGPHSYH
What are the official names of this protein?
MAPK-interacting and spindle-stabilizing protein-like, Mitogen-activated protein kinase 1-interacting protein 1-like.
What is the protein family that this protein belongs to?
Belongs to the MISS family.
Protein: LOLB_SALPB
Sequence: MTLPDFRLIRLLPLASLVLTACTLPGHKGPGKSPDSPQWRQHQQEVRHLNQYQTRGAFAYISDDQKVYARFFWQQTGQDRYRLLLTNPLGSTELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLTGMPIPLNSLRQWILGLPGDATDYKLDDQYRLSEVNYRQDGKNWKVVYGGYDSKTQPAMPANMELSDGSQRIKLKMDNWIVK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: RL11_ACIB3
Sequence: MAKKIDGYIKLQVPAGKANPSPPIGPALGQRGVNIMAFCKEFNAATQKVEPGLPIPVVITVYNDKSFTFIMKTPPASILLKKAAGIQKGSSVPNKTKVGKLTRAQLEEIATTKEPDLTGADLDARVRTIAGSARSMGLEVEL
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: LPOA_HAEDU
Sequence: MATILKQKLKTFFVPTAITLLLSACNSTSLFENSVTYLIKQEAYASSEFYINKAEQTLNSQDKITYQLLAVRKLIDENKVVEAQNTLNDLTTRLNIMEQNPLQQLEYQLVTAQLAALKGNNHQAEVTLQHISAANLSHSQLLRFYQTQAKIAENSKNTIEAVRIRSLIATQLVDNKLRQENNDKIWSLLRNANRGMLSSAQAGAGEMELAGWLALIEIYNQSVSTPAQMPQNINYWKRLYPNHSALAVMPTELQRVFNFQQTLLNNVALLLPLSGDAKILGEIIKKGFDDAKEQDPTIVQVFDTDSNSIENILMQAKQQGAQMIIGPLLKSRVNQMLASDQIRDINVLALNATQDVKPIVGVCYYGLSPEAEARSGADRLSRDGYTKAIVVAARDEFGQRSAEAFAQRWRQLTNTDADIRYYNQPLDVITTIQNSANNLQETALYALGNAEQLLEIKQGLENSTIAGQLAIYTASRSNSPNNGIEFRTAMEGVKFSEIPLLADHNSNEYQKAYSLADSDFSMMRLYAMGSDTWALANKFNEFRQIPGYSISGLTGNLNAGPNCNIERNMTWLQYHNGAVETTN
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
What are the official names of this protein?
Penicillin-binding protein activator LpoA, PBP activator LpoA.
What is the protein family that this protein belongs to?
Belongs to the LpoA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: VIRB8_BARQU
Sequence: MKNSLIKIRKSLVKSDAFDEYVKEARSFDIDRMHSLQQRMRIAMTLTVLFGLMTIALALAVAALTPLKTVEPFVIRVDNSTGIIETVSALKETPNNYDEAITRYFAGKYVRAREGFQLSEAEYNFRLISLLSSPEEQNRFAKWYSGNNPESPQNIYHNMTAKVTIKSISFLSKDLIQVRYYKTIRELNGKENISHWVSILNFSYINAHISTEDRLINPLGFQVSEYRSDPEVIK
What is the function of this protein?
Component of the type IV secretion system VirB/VirD4 which could be a major virulence determinant for subversion of human endothelial cell (HEC) function.
What are the official names of this protein?
Type IV secretion system protein virB8.
What is the protein family that this protein belongs to?
Belongs to the virB8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: NADD_HERAR
Sequence: MKSVTRCIALLGGSFDPVHNGHVALADYFVALLKPDELRVIPAGNPWQKHGLQASGQDRMAMVRSAFSTQKVTVNIDQQEILRPSATYTIDTLRAIRQELGPHASIVFLMGADQLQHLNTWQEWQHMFDYAHICAASRPGFAMDAAHIPTEVAQEFTRRTGTPEQIRTTPQGLAYLAPNLAVDISATAIRAALQRGERPTSQLPLGVLDYIEQHHLYKS
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: PFDA_SULIA
Sequence: MSQGQGGITLDDLIAQADYLKRYIDSLQRTQLELLESINSIDSAKQAIETIKSGNKEMLVFIDRKGYLLAKVGGIIGDKVTVHLGLSYYAEVDLDSAIKILDKRKDEISKAAQNLNNELQKAASTYNQIVDILNQIQQAAARRQQGE
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit alpha, GimC subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the prefoldin alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMC3_XENLA
Sequence: MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKRDKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSSKRETSGEKSRQLRDAQQDARDKMEEIERQVRELKSKISAMKEEKEQLSSERQEQIKQRTKLELKTKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFSSVKQKEESGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAINKDLEETEVNKEKNLEQYTKLDQDLNEVKTRVEELDKKYYEVKNKKDELQSERNYLWREENAEQQSLAAKREDLEKKQQLLRAATGKAILNGIDSINKVLEHFRRKGINQHVINGYHGIVMNNFDCEPAFYTCVEVTAGNRLFYHIVESDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNLRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKVEDELHALEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGTITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTLARSEGLDITIDKTEVESKDLVKSMDRWKNMEKDHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGHKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSTQSSVPSVDQFTGVGIRVSFTGKQAEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELASHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITAEQAKDFVEDDTTHG
What is the function of this protein?
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle.  The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped.  At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.  Cohesion is coupled to DNA replication and is involved in DNA repair.  The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
What are the official names of this protein?
Structural maintenance of chromosomes protein 3, SMC protein 3, SMC-3.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Protein: RL35_BRAHW
Sequence: MKQKLKTKSGAKKRFRFSKTGKVKFAHAFGSHKFLSKRPDTKRKYRKARIADDTNMLEMPRLMPYGR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: SPEA_SHESM
Sequence: MNDWSIDAARAGYNVTHWSQGFYGISDQGEVTVSPDPKNPDHKIGLNELAKDMVKAGVALPVLVRFPQILHHRVNSLCQAFDQAIQKYEYQADYLLVYPIKVNQQKTVVEEILASQASKEVPQLGLEAGSKPELMAVLAMAQKASSVIVCNGYKDNEYIRLALIGEKLGHKVYIVLEKLSELKMVLAESKRLGVKPRLGLRARLAFQGKGKWQASGGEKSKFGLSAAQILTVVDQLKENDMLDSLQLLHFHLGSQIANIRDIRQGVSEAARFYCELRELGASINCFDVGGGLAVDYDGTRSQSNNSMNYGLSEYANNIVNVLTDICNEYEQPMPRIISESGRHLTAHHAVLITDVIGTEAYQVEDIQPPAEESPQLLHNMWQSWTELSGRADQRALIEIYHDSQSDLQEAQSLFALGQLSLAERAWAEQANLRVCHEVQGLLSTKNRYHRPIIDELNEKLADKFFVNFSLFQSLPDAWGIDQVFPVLPLSGLDKAPERRAVMLDITCDSDGIVDQYVDGQGIETTLPVPAWSAESPYLMGFFMVGAYQEILGDMHNLFGDTNSAVVSIEENGMTNIESVLAGDTVADVLRYVNLDAVDFMRTYEELVNQHIVEEERAQILEELQVGLKGYTYLEDFS
What is the function of this protein?
Catalyzes the biosynthesis of agmatine from arginine.
What are the official names of this protein?
Biosynthetic arginine decarboxylase, ADC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
Protein: ADRL_SCHPO
Sequence: MSESEQLLEKQQDHKWDAATHADKGITIKTGKIAVSSSDIPLRNRKGLLTWDQLEPWQQDNQYIISGYRPPSFSFYLCVKSIFHVHNESVNIWTHLFGAIVFLFFIFKSELILKRDTTTAEDVYVITVFLFSAFTMLGCSTFYHTISNHSDDVSKFGNKLDYLGIVVMIVGSFIPCLHYAFACHANFRTLYIGTIIGIGVIVASTCLLDRFRQPEWRPYRALIFVLMGLFGIFPVIHALKIFSFSEILVRMGLVWLLLQGLFYIVGAVIYALRIPEKWSPGKYDVFGSSHQWFHVCVIIAAFCHFHGVCIAYDYFHERRGCGEM
What is the function of this protein?
Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation.
What are the official names of this protein?
ADIPOR-like receptor SPBC12C2.09c.
What is the protein family that this protein belongs to?
Belongs to the ADIPOR family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL7_SHEWM
Sequence: MSITKDQILEAFAEMSVMEVVELIEAMEEKFGVSAAAAVVAGGAEGGAAAAEQTEFDVMMTSFGANKVAVIKALRGATGLGLKEAKAMAESAPVAVKEGLEKAEAEALKAELEAAGAEVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RS19_CHLPD
Sequence: MPRSLKKGPFIDFKLEQRILDMNSKGEKKVLKTWSRSSMISPDFVGHTIAVHNGKTHVPVYVGDNMVGHKLGEFAPTRTFRGHAGGKAEKGGSAPKKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: EIF3C_MOUSE
Sequence: MSRFFTTGSDSESESSLSGEELVTKPVSGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGVGNTTFLKKKQESSGESRKFHKKMEDDDEDSEDSEDEEWDTSSTSSDSDSEEEEGKQTVLASKFLKKAPTTEEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQVRGKKGTDRATQIELLQLLVQIAAENNLGVGVIVKIKFNIIASLYDYNPNLATYMKPEMWQMCLDCINELMDTLVAHSNIFVGENILEESENLHNFDQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEICQIYLRRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 subunit 8, eIF3 p110.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL16_DEHMB
Sequence: MLQPKRVKFRKVQRGRRDGAAHKGNTVAFGEFALQSLEAGWITARQIEATRRAITRYIRRGGQVWIRIFPDKPITKKPAETRQGGGKGAPEEWVAVVRRGRIMFEIGGVTPEAAKEAMRLASYKMPVKTRFVARDIPVVAGETEVEEAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: RBL_GALAP
Sequence: MSPQTETKAGVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEERGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEEEQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTTLSHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDYIEKDRSRGIYFTQDWVSLPGVLPVASRGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLAVEGGEIIREACKWSP
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PA2HB_AGKPL
Sequence: MRTLWIVALLLVGVEGSVLELGKMILQETGKNAITSYGSYGCNCGWGHRGQPKDATDRCCFVHKCCYKKLTDCNHKTDRYSYSWKNKAIICEEKNPCLKEMCECDKAVAICLRENLDTYNKKYKAYFKLKCKKPDTC
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity (PubMed:28633930).  Does not show antibacterial activity (PubMed:29928892).  Is myotoxic and displays edema-inducing activities (By similarity).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog APL-K49, svPLA2 homolog, AplP2.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PHS_CHLSY
Sequence: MPRLSEAEIAEQLAQRPDWSLENNEIVRTFRLANFPAAIAFVTHVAFLAEAAGHHPDIDIRYNRVRLALTTHDAGGLTEKDFALAAAIDEIMG
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: PAX9_CHICK
Sequence: PAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLSQQGHYESYKQHQPPPQPPLPYNHIYSYPSPIAAAGAKVPTPPGVPAIPGTMAMPRTWPSSHSVTDILGIRSITDQVSDTSSYPSPKVEEWSSLGRSSFPPAAQHAVNGLEKSSLEQEAKYSQAHNGLPAVGSFVSAPAMSPYATSAQVSPYMPYSAAPSSYMAGHGWQHTAGTPLSPHGCDLPASLAFKGVQTAREGSHSVTASAL
What are the official names of this protein?
Paired box protein Pax-9.
What are the subcellular locations of this protein?
Nucleus.
Protein: FPP2_ARATH
Sequence: MMTGTTLILEPVMDSKDELVKQHAKVAEDAVAGWEKAENEVVELKQKLEDAADKNIVLEDRVSHLDGALKECVRQLRQFRDEQEKNIQAAVTESTKELHSANTGLEKRVLELQKEAEAAKSENMMLRREFLTQREDLEIVMIERDLSTQAAETASKQHLDIIKKLAKLEAECRKLRILAKTSSSLSSNQSVDSHSDGGRERVEGSCSDSWASSAFISELDQIKNEKGGNRSLQGTTSSTEIDLMDDFLEMERLVALPTETQAKNSKDGYELSLMEKLEKIQAEKDDLEREVKCCREAEKRLSLEIEAVVGDKMELEDMLKRVEAEKAELKTSFDVLKDKYQESRVCFQEVDTKLEKLQAEKDELDSEVICCKEAEKRFSLELEAVVGDKIEMEDELEKMEAEKAELKISFDVIKDQYQESRVCFQEVEMKLEAMKRELKLANESKTQAESRVTRMEAEVRKERIVSDGLKEKCETFEEELRREIEEKTMIKREKVEPKIKQEDIATAAGKFADCQKTIASLGKQLQSLATLEEFLIDTASIPGSARSVHNKEALLGKDPHECIKTINGRSLEFLAIQNSNNKTSPPCSSSSDSTTVSLIMSSNRGSSEKNRNGFATVFTRSRNSVNLGI
What is the function of this protein?
Ensures, when in complex with FPP3/VETH1 and COG2, the correct secondary cell wall (SCW) deposition pattern by recruiting exocyst components to cortical microtubules in xylem cells during secondary cell wall deposition by recruiting EXO70A1.
What are the official names of this protein?
Filament-like plant protein 2, AtFPP2, Protein VESICLE TETHERING 2.
What is the protein family that this protein belongs to?
Belongs to the FPP family.
What are the subcellular locations of this protein?
Vesicle. Note=Present in vesicle-like small compartments which exhibit microtubule plus-end-directed and end-tracking dynamics.
Protein: 3NO2_NAJKA
Sequence: MKTLLLTLVVVTIVCLDLGYTLTCLNCPEMFCGKFQICRNGEKICFKKLHQRRPLSWRYIRGCADTCPVGKPYEMIECCSTDKCNR
What is the function of this protein?
Neurotoxin that irreversibly inhibits nicotinic acetylcholine receptors (nAChR) and allosterically interacts with muscarinic acetylcholine receptors (mAChR) (PubMed:11279130, PubMed:19682302).  The loop II is involved in the interaction of this toxin with nAChR and mAChR (PubMed:27343701, PubMed:26242733).  On nAChR, it acts as a competitive antagonist (muscle-type and alpha-7/CHRNA7) with IC(50) values in the micromolar range (PubMed:11279130, PubMed:27343701).  On mAChR, in presence of ACh, it partially inhibits the effect of acetylcholine (ACh) (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist) (PubMed:19682302).  It also shows a very weak inhibition of GABA(A) receptor composed of alpha-1-beta-3-gamma-2 (GABRA1 and GABRB3 and GABRG2) subunits (10 uM inhibit 31% current) (PubMed:26221036).  In vivo, is nonlethal to mice at concentrations up to 20 mg/kg, but exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats (PubMed:15581687, PubMed:17371532).
What are the official names of this protein?
Tryptophan-containing weak neurotoxin, WTX.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Ancestral subfamily. Orphan group II sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RNZ_METTH
Sequence: MMEVTFLGTSSAVPSKNRNHTSIALRIPGEIFLFDCGEGTQRQMALAGISPMKVTRIFITHLHGDHILGIPGMIQSMGFRGREEPLDIYGPPGIHELHECIMKMGYFTLDFDINVHEVRGGTVVEEDDYRVTSAPASHSVFNLAYCFEEKKRPRFLREKAIALGLKPGPAFGKLHRGIPVRVGDRIIMPEEVLGSPRKGVKVCYSGDTRPCESVIKLAEGAELLIHESTLEAGSEDKAAESGHSTAREAAEVARSAGVKRLILTHLSTRYKRTEVILEAARQVFPVTDVADDLMTVEVKAYDSSPDS
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: HIS7_AZOVD
Sequence: MAERTACVERNTLETRIKVSVNLDGTGKTRFATGVPFFEHMLDQIARHGLIDLDIECQGDLHIDDHHTVEDVGITLGQAFARAIGDKKGIVRYGHSYVPLDEALSRVVVDFSGRPGLSMQVPYTRARVGSFDVDLFQEFFQGFVNHAQVTLHIDNLRGSNTHHQIETVFKAFGRALRMAVEPDPRMVGQTPSTKGCL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB4_PIG
Sequence: MESILESRSGHWAGGPAPGQFYRIPPTPGSIVDPXSVLYGSPITRTQNPMVTGTSVLGVKFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDEELLGDGHSYSPKAIHSWLTRAMYNRRFKMNPLWTT
What is the function of this protein?
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).  SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
What are the official names of this protein?
Proteasome subunit beta type-4, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain, Proteasome chain 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.