PharMolix/UniProtQA huggingface dataset:
Protein: Y2360_STAAN
Sequence: MKILDRINELANKEKVQPLTVAEKQEQHALRQDYLSMIRGQVLTTFSTIKVVDPIGQDVTPDKVYDLRQQYGYIQN
What are the official names of this protein?
UPF0291 protein SA2360.
What is the protein family that this protein belongs to?
Belongs to the UPF0291 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_AZOSB
Sequence: MTISGVLAGCPAPAKLNLFLHVVGRRDDGYHLLQTAFRLLDWGDRLDFRVRDDGLIRRTNQVAGVAEDDDLVVRAARRLQQATGTPLGADITLHKVLPMGGGVGGGSSDAATTLIALNHLWQTGLTRADLQQLGLALGADVPFFIYGRDAFAEGVGEAFQPLALPAAVYVVLSPEVSVPTAEIFSAKGLTRDTPPIRIADFAASPTRNDLQATACSRYPEVARAINWLEHYAPARMTGSGACVFAEVASEIEADEIVSLCPARWKAWKAKSLARHPLYGLLD
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: CP4AA_MOUSE
Sequence: MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHEKFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPKANGAYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHTDGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHLKKLH
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids.  Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long-chain fatty acids (By similarity).  Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:17112342) (By similarity).  In kidney, may play an important role in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (By similarity).  Also participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) in kidney by converting 8,9-epoxyeicosatrienoic acid (EET) to 20,8,9-HEET, an activator of PPARA.  Displays substantially lower fatty acid omega-1 hydroxylase activity (By similarity).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
What are the official names of this protein?
Cytochrome P450 4A10, CYPIVA10, Cytochrome P450-LA-omega 1, Cytochrome P452, Lauric acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.
Protein: APT_CAMJR
Sequence: MIKLTQEEQKYLLDSIRIIPDFPKKGIIFRDITTLLNNKEALNFLLKHLKERYKDYNLDFIAGTESRGFIFASMICAKLNLPFVPIRKPGKLPFETFSCEYDLEYGSDKVELHKDAFKNIQNARVLLVDDLIATGGTAIASYELIQKAGAKCVEACFLMNLKDLNGANKLEKLTSVYSVLEI
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SBP_BACSU
Sequence: MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGGIRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVIRRNLLTKWTLSKKNKKNVI
What are the official names of this protein?
Small basic protein.
What is the protein family that this protein belongs to?
Belongs to the sbp family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: BRM1L_CHICK
Sequence: MPVHSREKKENNHDEMEVDYGENEGSTSEEEETESSSVSEEGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLAALQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKPEPPVKLEKHLHSARSEEGRLYYDGEWYGRGQTIYIDKKDECPTSAIITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHNHN
What is the function of this protein?
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity.
What are the official names of this protein?
Breast cancer metastasis-suppressor 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the BRMS1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CYAD_BORP1
Sequence: MRRALRELAARHGRVLAASWRQRHRRPAGWFDPVETEFLPSALSLQERPISPTARWLARILMALAAGALVWSVVGKTEIVVHAAGKVVPVGQSKIIAASETGRVARVLVADNSRVAAGDVLLRLDAGVTEAEERKWRVQAAQARQDEARSRAMIRALDTGRAPVLAELPADPGMMAAQSYLDSQYADYQAQLRSIEAAIATYRRELGLVTQIAHAHRGLRRDGDVSQQAYLEKEQARMTLEGRLRQSEAQRAALQTQTRRQAFETLVLARKLAAQAEQEIARTSAQRSRLVLTAPVDGVVQQLVALTEGTAVAATQPLMMVVPSGAGIQVQAQLDSKDIGFVRAGAPATVKVGAYDYTKYGTLEGKVLYVSPDTVVDDRQQHSYRVTIALAHPALEVDGKPRLLKEGMAVQADIRTGSRRLIEYLLSPVARHAGESLGER
What is the function of this protein?
CyaD is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).
What are the official names of this protein?
Protein CyaD.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL4_SYNJA
Sequence: MASCVVKNWQGETVGSAELSLKVARPETASHILYLALRRQMTNARQGNAHTKTRAEVRGGGRKPWRQKGTGRARAGSIRSPLWRKGGVIFGPRKREYNLAMNRKERQLALRTALQSRVEDLIVVEDFQDQLNPPKTRAVAQALLRWGVMEDQSALLIVAERSEAVERAVRNIARVKLIGLDQLNVFDLLNVDWVLITTSALEKLKARWGSGAAAAAPTQADRLEDQAQAAEREARPVEQAEGQSQEQEEQAEAQAQPEAPPAQADQANQVALANPQVQETQEEELAQAQEREVQGQAELAQEAEPLAQPPAGEEAETAAAEEEDND
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: YCF4_CYAM1
Sequence: MSIQRESIIGSRRWSNMIWCAILVTAGSGFWFNGMQSELALQGAIMCFYGSVAVTLSVYLFLTIWWDVGGGYNEYDTENKSITIWRRGFGNKTIFLKYTRDQMQALKVVVKDGLNPKREIYLCTTTGAQIPLTAVGEPMPLAELEQKATQLAQWLNLSLVGMRA
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: HXA4_LINSA
Sequence: AANGNFNGSESKRSRTAYTRHQILELEKEFHFNRYLTRRRRIEIAHALDLSERQIKIWFQNRRMKWKKEHKLPNTKLRLP
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein Hox-A4, LsHox 4.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family. Deformed subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SELD_METKA
Sequence: MSRKKSLVEMADLHGUACKLPQGDLEDLLKGVELPEEGGRVEVGVGDDAAVIRVDGGYVIQSVDFFTPIHPDPYTQGRIAANNSINDVFAMGATEVLSVLVVSGFPRELPEEDAREMLQGFADQCREVDALIVGGHTIMNPWPILGGCVTGFAERYVTVGGAEPGDVLYLTKPLGTQPAMAALRLPEDVRKQFLTDSELEEAVDLAVEVMTEPLKDAAEAALEVGVHAMTDVTGFGLKGHAGEMAEASGVRVVIERLPVIPGTTELSRALGYGLERGESAETAGGLLVAVPEEHAEDLEDAFERRDVWYRRIGRVEEGSGVEVRGDVEEVEDYP
What is the function of this protein?
Synthesizes selenophosphate from selenide and ATP.
What are the official names of this protein?
Selenide, water dikinase, Selenium donor protein, Selenophosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Protein: SYA_FLAJ1
Sequence: MKSQDVRKQFLDFFESKGHTIVPSAPIVLKDDPTLMFNNSGMAQFKEFFLGNGTPKSPRIADTQKCLRVSGKHNDLEEVGIDTYHHTMFEMLGNWSFGDYFKKEAINWAWELLTEVYKIPKENLYVSVFEGSKEDNVPFDQEAWDIWKTLIDEDRIILGNKKDNFWEMGDQGPCGPCSEIHVDLRSAEEKALVSGKSLVNNDHPQVVEIWNNVFMEFNRKADGSLEKLPAQHVDTGMGFERLCMALQGKTSNYDTDVFMPLIREIETITGAKYTTNDVTGISEEQNKMNIAIRVVADHVRAVAFAIADGQLPSNTGAGYVIRRILRRAIRYGFTFLGTKEPFIYKLVETLSEQMGDSFPEIRTQKALCSNVIREEENSFLKTLDQGLILLDAVILNNTGDTIDGKKAFELYDTYGFPIDLTALILSERGLKLDEEGFQEQLQLQKERSRAASKVTAGDWNVIVEDDIQEFVGYDRLSQQVKITKYRRVESVKDGEIFQLVFNATPFYGESGGQTGDKGYLEAQNGDIVYIIDTKKENNQTIHLTQSLPENITGTFNAVVDANQRAKTSSNHSATHLLHQGLRKILGTHIEQKGSMVRNASLRFDFSHFSKVTDEELLEVENFVNARIRESLPLIEKRAIPKEQALEDGAIALFGEKYGDLVRTIKFGDSVELCGGTHVANTSDIWHFKIVSEGAVAAGIRRIEAITSEAAKEYFESQAVSLAEIKEALKNAQDPVKSILALQDENAQLKKQLEALLKDKAKNMKADLAKELQEINGVQFLAKQVDLNPEGAKDLAYELGGSYNNLFVVFATAHEGKPMLTCYISKEIVASKNLNAGQVVRELGKYIQGGGGGQPFFATAGGKNVDGIGEALAKAVDFVK
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPA1_SOLTU
Sequence: MGSLCSRNKHYSQADDEENTQTAEIERRIEQETKADKHIQKLLLLGAGDSGKSTIFKQIKLLFQTGFDEAELKNYIPVIHANVYQTIKILHDGSKELAQNELEASKYLLSAENKEIGEKLSEIGGRLDYPRLTKDLVQDIEALWKDPAIQETLLRGNELQVPDCAHYFMENLERFSDIHYIPTKEDVLFARIRTTGVVEIQFSPVGENKKSGEVYRLFDVGGQRNERRKWIHLFEGVTAVIFCAAISEYDQTLFEDERKNRMMETKELFEWVLKQPCFEKTSFMLFLNKFDIFEQKVLKVPLNTCEWFKDYQSVSTGKQEIEHAYEFVKKKFEESYFQCTAPDRVDRVFKIYRTTALDQKLVKKTFKLVDETLRRRNLFEAGLL
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
What are the official names of this protein?
Guanine nucleotide-binding protein alpha-1 subunit, GP-alpha-1.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family.
Protein: GLNH_GEOSE
Sequence: MKRKTVWKIWITLALIALLSITALAGCSSESSTTNKEDGAKSTETSAGTNTLEKIKKRGKLIVGVKYDLNLFGLKNPETGKVEGFDIDIAKGLAKKILGDENKIELKEVTSKTRIPMLNNGEIDAIIGTMTITEERKKEVDFSDVYFMAGQSLLVKKDSKINSVKDLKKGMTVLTAKGSTSAQNIRKVAPEVNVLEFENYAEAFTALKAGQGDALTTDNALLWGMAKQDPNYRVLDETFSKEPYGIGSAKETKNYCKSLTNT
What is the function of this protein?
Involved in glutamine-transport system.  Interacts with the glutamine-transport system GlnPQ.
What are the official names of this protein?
Glutamine-binding protein, GlnBP.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 3 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: LEUD_SINFN
Sequence: MDKFVKLTGVAAPLPVVNIDTDMIIPKDYLKTIKRTGLGTGLFAEARYNEDGTPNPDFVLNKPAYQNAKILVAGDNFGCGSSREHAPWALLDFGIRCVISTSFADIFYNNCFKNGILPIVVSQADLDKLMDDANRGSNAVLSIDLEAQEITGPDGGSIKFEIDAFKRHCLLNGLDDIGLTLEKAGAIDTFEKSTAASRPWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TRPF_BRUA2
Sequence: MALDIKICGLKTPEAVAAALDGGATHIGFIFFPKSPRHITPDAAARLRAAATGRAVAVAVTVDADDEALDEIVKTVRPDMLQLHGGETPERVRFLKERYNLPVMKAFSIREAGDLEAIAPYRGIADRFLFDAKPPKGSELPGGNGISFDWNLLAALDADIDYMLSGGLNADNIAEALLKTGAPGIDISSGVECAPGEKDVRLIENFFQAVADANAQPFARRA
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: SYG_MYCTO
Sequence: MHHPVAPVIDTVVNLAKRRGFVYPSGEIYGGTKSAWDYGPLGVELKENIKRQWWRSVVTGRDDVVGIDSSIILPREVWVASGHVDVFHDPLVESLITHKRYRADHLIEAYEAKHGHPPPNGLADIRDPETGEPGQWTQPREFNMMLKTYLGPIETEEGLHYLRPETAQGIFVNFANVVTTARKKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPATAKEWHQYWIDNRLQWYIDLGIRRENLRLWEHPKDKLSHYSDRTVDIEYKFGFMGNPWGELEGVANRTDFDLSTHARHSGVDLSFYDQINDVRYTPYVIEPAAGLTRSFMAFLIDAYTEDEAPNTKGGMDKRTVLRLDPRLAPVKAAVLPLSRHADLSPKARDLGAELRKCWNIDFDDAGAIGRRYRRQDEVGTPFCVTVDFDSLQDNAVTVRERDAMTQDRVAMSSVADYLAVRLKGS
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRS35_RAT
Sequence: MLLWLIIFVSGWTLSLGSETEPDFTWHLSRIPQVVSEKTIHLASPTFQADAAAVKATVCGIECQEELPAPSLSQLEDFLSYETVFENGTRTLTRVKVQGLVLEPTQNSSIKGARPRRRRQVYGTDSRFSILDKRFLTNFPFNTAVKLSTGCSGALVSPNHVLTAAHCVHDGKDYVKGSKKLRVGVLKMRNKGGRKKRRGSRRSRREAESGGQSPEHPQESTTQRPGKKSRRGPRVAQGRPSFQWTRVKSTHIPKGWARGENGDPALDFDYALLELKRAQKQQYMELGVSPTISKLPGGRIHFSGFDNDRDDQLVYRFCSVSEESNDLLYQYCDAEAGSTGSGIYLRLKEPGQKNWKRKIIAVYSGHQWVDVHGVQKDYNVAVRITPLKYAQICLWIHGNAANCAYG
What are the official names of this protein?
Inactive serine protease 35.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PO6F2_HUMAN
Sequence: MSALLQDPMIAGQVSKPLLSVRSEMNAELRGEDKAATSDSELNEPLLAPVESNDSEDTPSKLFGARGNPALSDPGTPDQHQASQTHPPFPVGPQPLLTAQQLASAVAGVMPGGPPALNQPILIPFNMAGQLGGQQGLVLTLPTANLTNIQGLVAAAAAGGIMTLPLQNLQATSSLNSQLQQLQLQLQQQQQQQQQQPPPSTNQHPQPAPQAPSQSQQQPLQPTPPQQPPPASQQPPAPTSQLQQAPQPQQHQPHSHSQNQNQPSPTQQSSSPPQKPSQSPGHGLPSPLTPPNPLQLVNNPLASQAAAAAAAMSSIASSQAFGNALSSLQGVTGQLVTNAQGQIIGTIPLMPNPGPSSQAASGTQGLQVQPITPQLLTNAQGQIIATVIGNQILPVINTQGITLSPIKPGQQLHQPSQTSVGQAASQGNLLHLAHSQASMSQSPVRQASSSSSSSSSSSALSVGQLVSNPQTAAGEVDGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRHTILRSHFFLPQEAQENTIASSLTAKLNPGLLYPARFEKLDITPKSAQKIKPVLERWMAEAEARHRAGMQNLTEFIGSEPSKKRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNTIKRLKQHEPATAVPLEPLTDSLEENS
What is the function of this protein?
Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells.  Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'.  Isoform 1 does not bind DNA.
What are the official names of this protein?
POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1, RPF-1.
What is the protein family that this protein belongs to?
Belongs to the POU transcription factor family. Class-6 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SCPA_PENSP
Sequence: AYSWDNRVKYVVRYMYDIDDDGFLDKNDFECLAVRNTLIEGRGEFSAADYANNQKIMRNLWNEIAELADFNKDGEVTVDEFKMAVQKHCQGKKYSEFPGAFKVFIANQFKAIDVNGDGKVGLDEYRLDCITRSAFAEVKEIDDAYDKLTTEDDRKAGGLTLERYQDLYAQFISNPNESCSACFLFGPLKVVQ
What is the function of this protein?
Like parvalbumins, SCPs seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.
What are the official names of this protein?
Sarcoplasmic calcium-binding protein, alpha-B and -A chains, SCP alpha chain.
Protein: ILVC_STRT2
Sequence: MAVQMEYEKDVKVPALDGKKIAVIGYGSQGHAHSQNLRDTGHDVIIGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAVGFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKDIAMDWCKGIGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIETGFEVLTEAGYAPELAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEFGDYVSGPRVITEQVKENMKAVLTDIQNGKFANDFVNDYKAGRPKLTAYREEAANLEIEKVGAELRKAMPFVGQNDDDAFKIYN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: UPPP1_STUS1
Sequence: MDLWVAIQALILGVVEGITEFLPVSSTGHQIIVADLIGFGGERALAFNIIIQLGAILAVIWEYRRKIIDVVVGLPEERQAQKFTVNLLIAFMPAVVLGVAFADLIHEYLFNPITVAAALVIGGIVMLWAERRDHAIRAETVDDMTWTLALKVGFAQCLALVPGTSRSGSTIIGGLLFGLSRKAATEFSFFLAMPTMVGAAVYSGYKYRDLFQPGDFAVFAIGFVTSFIFAMLAVRALLKFIGNHSYAAFAWYRIGFGLLILATWQLGMIDWSTAIG
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 1, Bacitracin resistance protein 1, Undecaprenyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
Protein: GSTD1_DROME
Sequence: MVDFYYLPGSSPCRSVIMTAKAVGVELNKKLLNLQAGEHLKPEFLKINPQHTIPTLVDNGFALWESRAIQVYLVEKYGKTDSLYPKCPKKRAVINQRLYFDMGTLYQSFANYYYPQVFAKAPADPEAFKKIEAAFEFLNTFLEGQDYAAGDSLTVADIALVATVSTFEVAKFEISKYANVNRWYENAKKVTPGWEENWAGCLEFKKYFE
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028, PubMed:20417639).  Has DDT dehydrochlorinase activity (PubMed:20417639).  May be involved in detoxification (PubMed:22082028).
What are the official names of this protein?
Glutathione S-transferase D1, DDT-dehydrochlorinase.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Delta family.
Protein: DNJA1_RAT
Sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
What is the function of this protein?
Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis.  Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV.  Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (By similarity).  Co-chaperone for HSPA8/Hsc70.  Plays a role in protein transport into mitochondria via its role as co-chaperone (PubMed:10816573).
What are the official names of this protein?
DnaJ homolog subfamily A member 1, DnaJ-like protein 1, Heat shock protein J2, HSJ-2.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor. Cytoplasm. Microsome. Mitochondrion. Nucleus. Cytoplasm, perinuclear region. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria.
Protein: RAD4_ARATH
Sequence: MKSRSESKNCRLAQASRVAVNKVLDKSSARGSRGKKKQDDNCDSAKRDKGVNGKGKQALDARLIDNVLEDRGCGNVDDDEMNDSDWEDCPIPSLDSTVDDNNVDDTRELTIEFDDDVPDAKKQKNAYRATAEDKVRAELVHKVHLLCLLARGRIVDSACNDPLIQAALLSLLPSYLTKVSNLEKVTVKDIAPLLRWVRENFSVSCSPSSEKSFRTSLAFALESRKGTAEELAALAVALLRALKLTTRFVSILDVASLKPGADRNESSGQNRAKMKHGIFRTSTLMVPKQQAISSYPKKSSSHVKNKSPFEKPQLGNPLGSDQVQDNAVNSSCEAGMSIKSDGTRRKGDVEFERQIAMALSATADNQQSSQVNNTKKVREITKISNSSSVSDQVISTAFGSKKVDSPLCWLEVYCNGENMDGKWVHVDAVNGMIDAEQNIEAAAAACKTVLRYVVAFAAGGAKDVTRRYCTKWHTISSKRVSSVWWDMVLAPLVHLESGATHDEDIALRNFNGLNPVSSRASSSSSSFGIRSALEDMELATRALTESLPTNQQAYKSHEIYAIEKWLHKNQILHPKGPVLGFCSGHPVYPRTCVQTLKTKERWLRDGLQLKANEVPSKILKRNSKFKKVKDFEDGDNNIKGGSSCMELYGKWQMEPLCLPPAVNGIVPKNERGQVDVWSEKCLPPGTVHLRFPRIFAVAKRFGIDYAPAMVGFEYRSGGATPIFEGIVVCTEFKDTILEAYAEEQEKKEEEERRRNEAQAASRWYQLLSSILTRERLKNRYANNSNDVEAKSLEVNSETVVKAKNVKAPEKQRVAKRGEKSRVRKSRNEDESHEHVFLDEEETFDEETSVKTKRCKCGFSVEVEQM
What is the function of this protein?
May have a role in the nucleotide excision repair (NER) pathway.
What are the official names of this protein?
DNA repair protein RAD4.
What is the protein family that this protein belongs to?
Belongs to the XPC family.
Protein: RHG44_MOUSE
Sequence: MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLVEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLMISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNIQEQDKRLQALWNACEKLPKANHNNIKYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQSEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNLTGSYGSPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTSWVARRGSSAGRKASCAPPSMQPPAPPSELAAPLPSPLPEQVPDSPATPAPALSPSGASLQPTPERPSVSKSKELSPGSGQKGSPGSIQGTPCPGTQLGPQPAASPSQLPADQSPHTLRKVSKKVAPIPPKVPFVQPGTVSDQPVGQPSPVSLSPTPPSTPSPYGLSYPPGYSMASGQLSPASAPPLASPSVFTSTLAKSRPTPKPRQRPTLPPPQPPSVSLSASSPQSTEHPMLDGMSPGESMSTDLVHFDVPSIHIELGSTLRLSPLEHARRHSATDKRDSEEESESTAL
What is the function of this protein?
GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases.  Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states.  Acts as a GAP at least for CDC42 and RAC1 (PubMed:24352656, PubMed:26969129).  In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (PubMed:23739967, PubMed:24352656, PubMed:26969129).  Limits the initiation of exploratory dendritic filopodia.  Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces.  Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity).  In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (PubMed:23739967).
What are the official names of this protein?
Rho GTPase-activating protein 44, Rho-type GTPase-activating protein RICH2, RhoGAP interacting with CIP4 homologs protein 2, RICH-2.
What are the subcellular locations of this protein?
Cell projection, dendritic spine. Recycling endosome. Presynapse. Cell projection, dendrite. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites (PubMed:23739967). Located in convoluted dendritic plasma membrane sections enriched in polymerized actin and myosin (patches) along dendrites where often emerge filopodia (By similarity).