PharMolix/UniProtQA huggingface dataset:
Protein: NAC1_CAVPO
Sequence: MLRLSLSPTYSLGFHLLAMMTLLISHVDHITAETEMVEEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVAENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHISTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKHLYGQPVLRKVHARDHPIPSTVITIADEYDDKQPLTSKEEEERRIAELGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
What is the function of this protein?
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:7986817).  Contributes to Ca(2+) transport during excitation-contraction coupling in muscle.  In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum.  SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline.  Required for normal embryonic heart development and the onset of heart contractions (By similarity).
What are the official names of this protein?
Sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, Solute carrier family 8 member 1.
What is the protein family that this protein belongs to?
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.
Protein: CMC4_SCHPO
Sequence: MVDCQKEACNLQSCIQRNQYNQGNCEKFVNDLLLCCKRWYDKNSLTGNEAPHTCPELKPLLRQLSSRNLT
What are the official names of this protein?
Cx9C motif-containing protein 4, mitochondrial, Transcripts altered in meiosis protein 2.
What is the protein family that this protein belongs to?
Belongs to the CMC4 family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Imported into the mitochondria via the mitochondrial mia40-erv1 machinery.
Protein: PPME1_CRYNJ
Sequence: MSDMFRKSVLNKLPHLPPTRAPWADESEPIEEIDEEDEQLDGIGEFKPATMGPSKHDTQDYSPLSASTFFAQAAEVQPPSTPCTFRVYLTPPNLSIASANAGTPPGPSGLRTQQQTNRHGTYLVCHHGGGASGLGFAPLAREVKAKGNGEMGVLAFDCRGHGKTSTSDPNLELDLSHDTLLSDFMAIIEMMFPDPKESPSLILLGHSMGAAPVVSAAPELQKKGYTIPGVVVLDVVEGTAVESLPLMKSVLSKRPESFRSVIDAIYWHVTSNSIRNVESARVSVPHIIVPAPSSSSSDPSANPGGKQVWRTNLVGTEPYWEGWYKGLSQRFLRTKCARLLVLAGQERLDRELMVGQMQGKFQLEVMSDVGHYLHEDNPAGLAATLITFWHRNTRVLVLPPKIGAPGPGARGGPVEVKQVGQQ
What is the function of this protein?
Demethylates proteins that have been reversibly carboxymethylated.  Demethylates the phosphatase PP2A catalytic subunit (By similarity).
What are the official names of this protein?
Protein phosphatase methylesterase 1, PME-1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: CA43B_CONAH
Sequence: SDVRNAAVHERQKELVPSKITTCCGYSPGTACPSCMCTNTCKKKNKKPGRRND
What is the function of this protein?
Probable neurotoxin with ion channel inhibitor activity.
What are the official names of this protein?
Conotoxin Ac4.3b, KappaA-conotoxin.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RUVB_ALIF1
Sequence: MIEADRLIAADNPTFREEDVIDRAIRPKKLDDYQGQDHVRSQMEIFIKAAQMREEALDHLLIFGPPGLGKTTLANIVANEMGVNIRTTSGPVLEKAGDLAALLTNLEENDILFIDEIHRLSPMVEEVLYPAMEDYQLDIMIGEGPAARSIKIDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEYYKVEDLQHIVQRSADCLNLSMESEGALEVARRARGTPRIANRLLRRVRDYAEVMSDGNISSEIADKALNMLDVDVRGFDYMDRKLLLAIMEKFDGGPVGLDNIAAAIGEERDTIEDVIEPYLIQQGYLQRTPRGRIVSDRAYLHFGIDKPDK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: POLC2_BRACM
Sequence: MADATEKAEHDRIFKKFDANGDGKISASELGDALKNLGSVTHDDIKRMMAEIDTDGDGYISYQEFSDFASANRGLMKDVAKIF
What are the official names of this protein?
Polcalcin Bra r 2, Calcium-binding pollen allergen Bra r 2.
Protein: F217A_HUMAN
Sequence: MGRRNENCANSLRVSNISQENLSHWNLDSEVPVSENKNLPAGRDGAAGGKINKNYLEIPVEQLMLEPNLSVHSQKSTQNSKQGIFQLWNCPLNEGSTIEKREFKKSSVETGFNVINHPIRVFTLNHPLTIASVDKQVGPYPGLPMPLGLCWPYADGDFFKNRNEIHVSSCSTIENNDGETLPAPNWNLKHGNSSVEENFTDESDLSENEKTNDTLLSYFKKVDLNLKPETIKNVEEPFTEEPNEVFPYPDFLPPPFSALDLHNLALSKSDNWKVTVDPAETSVEHLITRLLELERLQHMTIQKERPRLQTTFCTPAVTERPSSSKATPKVRQPKLCDSLSLQIPCVDKSQEKSKNNSGSCKLEQNALKRNWSNAGKYRWNSRPLSLKSSSTPKQLIETYDKNPKSSILSPCQELSFKPTIGHTNQSMVKMVSTRCLPWRSPMPVSPIPLTFPENQKEEIKAPKRNFGTKKKLYRQNIVLNRPFSIQKLNCLSPSLIAKDKCCSPIEQK
What are the official names of this protein?
Protein FAM217A.
What is the protein family that this protein belongs to?
Belongs to the FAM217 family.
Protein: REX_STRPG
Sequence: MVIDKSIPKATAKRLSLYYRIFKRFHADQVEKASSKQIADAMGIDSATVRRDFSYFGELGRRGFGYDVTKLMNFFADLLNDHSTTNVILVGCGNIGRALLHYRFHDRNKMQIAMGFDTDDNALVGTKTADNIPVHGISSVKERIANTDIETAILTVPSIHAQEVTDQLIEAGIKGILSFAPVHLQVPKGVIVQSVDLTSELQTLLYFMNQNHLD
What is the function of this protein?
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
What are the official names of this protein?
Redox-sensing transcriptional repressor Rex.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory Rex family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCIB_PSEAB
Sequence: MKQFIDFIPLILFFIVYKIDPQNVEFAGFNLSGIYGATATLILASVIVYGALWLKHRHLEKSQWFTLGACLVLGGLTLAFHEDTFLKWKAPLVNWLFALAFAGSHFIGDKPMIQRIMGHAIQLPQGLWVRLNIAWVVFFLVCGFANLYVVFTYPNFWVDFKVFGSLGMTLLFLIGQGLFLARHLHDADTGEKPKD
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYK_SHEDO
Sequence: MTELVQDENKLIAERRAKLDHIRTQCPANAHPNTWERSHKAAELQAQYGENTKEELEALGYQTSIAGRVMAKRGPFLVIQDVSGRIQAYAGKPVQGDLKERYQGLDIGDIIGVKGQLHLSGKGDLYVNMEEYQLLTKALRPLPEKFHGLTDQETRYRQRYVDLIVNEESRNAFIMRSKVVSAIRNFMIKKEFMEVETPMMHVIPGGASARPFVTHHNALDMAMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGLSPRHNPEFTMMEFYMAYADYQDLMDLTEEMLSSIAIDLLGSAQMPYGEHTVDFGGPYARLSMLEAIQKYNPENATIQAMTYEQVKDVEFMRDLASSLGIKLEKFWTCGQLLEEIFGETAEPKLMQPTFITGYPADISPLARRNDNNDFITDRFEFFIGGREVANGFSELNDAQDQDNRFKAQVNAKDAGDDEAMFYDADYITALEHGLPPTAGQGIGIDRLVMLFTNTHTIRDVILFPAMRPQA
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_STAAW
Sequence: MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCECKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: ISPE_LISMC
Sequence: MKISITAPAKINLSLDALYKREDGYHEVEMVMTTIDLADRLYLERLDEDKIVLDVKAHFIPEDRRNLIYQAALLLKKRFDVKMGVRITIDKHIPVSAGLAGGSSDAAAALKGLNVIWELGLSIEELAEISSEIGSDIAFCVYGGTALATGRGEKISALPNIPGCWIVLAKPSISVSTPTIYKELQVDNVEHPDTQKMIESIKNGDLDGIFASTGNVLESVTLEKNPQVKRIKDRMLAFGAEAALMSGSGPTVFALIKQYSRAKRVYNGLRGFCEEVYMVRPWSEGENDTNINN
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PLSY_PROM0
Sequence: MNILIIFASYLLGSLPTGFLIGKYLKNIDLRTIGSGSTGATNVLRNVGKWPALFVFIIDLGKGLIAVKIAQYYTDQGLIEVIAGISAISGHIWPIWLRGKGGKAVATGLGMFLALSWKVGLASLGFFLIVLTKTKYVSLSSISAAILLPIFMFFYLGKFMHSYFFISLIVALLVIWKHRTNITRLLKGEESKINQTQ
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: EOGT_DROME
Sequence: MPILPILIGILHLSLAEDAKHLDGFSLPSLPSEHLIRYLNTFPKLKQQLPTNLTGKGTISSACWGHERDCTPAGRFQTPQCPGEHTGWARSKEAQVRTFYNQADFGYIQEQLSQLTPQCVPTYLGDSSLECTHYLRFCRGRNLLFDFRGLEQREERIRYHMDVLGPGQLLGHCKLNRTRLSGEMEHIGSALQSWGPELRNFDVLPHPVLESGLCDVVVNTPTFIMKIDATYNMYHHFCDFFNLYASLFVNQSHPAAFNTDVQILIWETYPYDSPFRDTFKAFSQRPVWTLSDVEGKRVCFKNVVLPLLPRMIFGLFYNTPIIQGCSNSGLFRAFSEFILHRLQIPYKPPQQKIRITYLSRRTKYRQVLNEDELLAPLEANDKYDVQRVSYERLPFTNQLAITRNTDILIGMHGAGLTHLLFLPNWACIFELYNCEDPNCYKDLARLRGVRYRTWEQRDLVYPQDEGHHPEGGAHAKFTNYSFDVKEFVHLVDGAAEEILSHKEFPRRASENPSKTQRNEL
What is the function of this protein?
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc).  Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.  Involved in epithelial cell adhesion/interaction with the extracellular matrix by mediating glycosylation of proteins in the secretory pathway, such as Dumpy (Dp).
What are the official names of this protein?
EGF domain-specific O-linked N-acetylglucosamine transferase, Extracellular O-linked N-acetylglucosamine transferase.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen.
Protein: QUEA_PROMM
Sequence: MVLDPRDSLLSSYDYPLDPERIAQLPVEPRHSARLLIVQPLGMKPPIARHAEVWDWQEELRAGDLLVINDTRVLKARLRVRRSGGGLAELLVLEPRGEGCWLCLGRPAKRLRPGDQLWLEALGEEPIALQVISKDSASGGRVVQFPSHYANAEQLELLLERYGEVPLPPYIQRHDPSDSERYQTRYASRPGAVAAPTAGLHLSDELLEALKQRGVMLTSVTLHVGLGTFRPVETEDLSHLQLHSEWVEVRDDVVEAVMACRARAGRVIAVGTTSVRALEGAALAGGGFLQSFCGPVDLVIQPGYRFAVVDGLLTNFHLPKSSLLLLVSAMVGRERLLALYAEAIEHQYRFFSYGDAMWIDPEAVLPAARPC
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RED1_PLARH
Sequence: MSKLWLLLLLVAAFQAVHSYPAAESDYLEEPETTWDILKETWGKMKDHYLNLGKETLAKLKELKENYKTWGKEKKQQFIATLKDKLCTPQDFEEDIDYAESDEDKDLSFTMKVLLILKETLDKLKAAVGEEKEKLIQEVKGLRAKICDKLSDYEEEEEFELEEDYEEDPETTWGILKEAWGKMKEHYLNLGKATLAKLKELKENYKTWGKEKLQIFVAKLKDKLCTQQDFEEDIDYTESDEEKDPALTAKILLKLKEYLEKLKSAAGKEKEKLIQKIKDLRAKICDKLSDYEEEEEEEEEEEFELEEDYEEDPQQTTWGILKETFGKIKDRWSQLTKIQLQKIIQVLKNRYCADQNDFEDDVAESDEEQGGRQVIQKYLQKLKEFYEKIKAAVGAKKEELKKRLEETRQKFCAKLNAAAEQNDLEEDEDEERGWLGKLGKGLKKVGKKFVKKMSSAMKAGCKKGMKMLKDNAVKVTPLVCEEKTCKTLVTILTYSCGMQYTITRTNKATYLEVAFIVNGEVKAKKNVKLGDVPSCVNLGALLGKICLKGIEGKGKSSSGQANVNFCLAILADKYNVGCKFCASYANKKFKVLPPKMFSGAQDDNGEILQASDNGEDGILLDADEFEID
What is the function of this protein?
Highly abundant protein that may be responsible for the observed disruption of sensory neuron membranes, since it is homologous to proteins such as trialysin, which forms pores in lipid bilayers (Probable).  Probable insecticidal toxin (By similarity).
What are the official names of this protein?
Venom redulysin 1, Red1.
What is the protein family that this protein belongs to?
Belongs to the redulysin-like family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS5_CLOPE
Sequence: MRIDPSTLDLKEKVVSISRVTKVVKGGRNFRFSALVVVGDENGHVGVGTGKSIEIPEAIRKGIEDAKKNLVEVSIVGTTVPHEIHGKFGTGDVLIMPATEGTGVIAGGPARSVLELAGLKDVRAKSLGSNNPRNMVKATINGLANLRTAEDIAKLRGKSVEEIIG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: SCX44_RHOJU
Sequence: KEGYPVDWGNCKYECMSDAYCKDLCADRKAKSGYCYKLNWSCYCEGLPDDSPIKTNGHCRPGGRRK
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
What are the official names of this protein?
Putative alpha-neurotoxin RjAa44.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1656_STAA3
Sequence: MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
What are the official names of this protein?
Putative universal stress protein SAUSA300_1656.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EMAL2_RAT
Sequence: MSSFGTGKTKEVIFSMEEGSVKMFLRGRPVPMLIPDELAPTYSLDTRSELPSSRLKLDWVYGYRGRDCRANLYLLPTGEVVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAVHPDMVTIATGQVAGTTKEGKPLPPHVRVWDSVSLSTLHVLGLGVFDRAVCCVAFSKSNGGNLLCAVDESNDHVLSVWDWAKESKVVDSKCSNEAVLVATFHPTDPNLLITCGKSHIYFWSLEGGNLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQEVLGAHDGGVFALCALRDGTLVSGGGRDRRVVLWGSDYSKVQEVEVPEDFGPVRTVAEGRGDTLYVGTTRNSILLGSVHTGFSLLVQGHVEELWGLATHPSRAQFVSCGQDKLVHLWSSETHQPVWSRSIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTDTRDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSTCFVTNSGDYEILYWDAATCKQITSADTVRNVQWATATCVLGFGVFGIWPEGADGTDINAVARSHDGNLLVSADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMVLTTGGKDTSVLQWRVA
What is the function of this protein?
Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.
What are the official names of this protein?
Echinoderm microtubule-associated protein-like 2, EMAP-2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EMAP family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle.
Protein: GC224_HUMAN
Sequence: MIPGNPSPGADLAVSKHFFSLSWFCGLLLLESKQK
What are the official names of this protein?
Putative gastric cancer-related gene 224 protein, GCRG-224, GCRG-p224.
Protein: RPOA_STRMU
Sequence: MIEFEKPIITKIDENKDYGRFVIEPLERGYGTTLGNSLRRVLLSSLPGAAVTSIKIDGVLHEFDTIPGVREDVMQIILNIKGLAVKSYVEEEKIVELDVEGPAEITAGDILTDSDIEIVNPDHYLFTIAEGANLKATMTVATNRGYVPAEKNKRDDAPVGTLAIDSIYTPVKKVNYQVEPARVGSNDNFDKLTIEIMTNGTIIPEDALGLSARVLIEHLNLFTDLTEVAKATDVMKETEQVSDEKVLDRTIEELDLSVRSYNCLKRAGINTVYDLTEKSESEMMKVRNLGRKSLEEVKVKLADLGLGLKNDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: TRUB_CLOD6
Sequence: MNKIISILKPTGMTSHDVVSRVRKILNIKKVGHTGTLDPDASGVLPICIGKATKVCEVILNKDKSYICELTLGISTDTYDASGEILKKVDDFKFSNEDIERAFDTQRGEINQLPPIYSALKVNGKRMCDLVRSGRQSEITLKTRRVNIKDIKILSIKGNKVMFYVECSKGTYVRSICHDIGEYLGCGAHMSFLNRTSSGKFDLDNSITLEELELFYENKTLDKYLYDIDYVLDSFNYVVLNPNAIKYYSNGGSIDDKRFLKNNFDKDDEFVRVYSTDNFLGLGKLSKHNNTISVKSDKMFI
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: TYSY_STRSY
Sequence: MTKADIIFKENIRKIMEEGVFSENARPRYKDGNVANSKYVTGAFAEYDLSKGEFPITTLRPIPIKSAIKEILWIYQDQTNDLSVLQEKYGVQYWNDWEVEGTGTIGERYGAIVKKHDIISKILKQLEENPWNRRNVISLWDYEAFDQSAGLLPCAFQTLFDVRRVDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLRRTPSEVEPRLVLNVPDGTNFFDIRAEDFELVDYNPVKPQLKFDLAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADDA_BACCR
Sequence: MIENWPKKPEGSQWTDDQWKAVVANGRDILVAAAAGSGKTAVLVERIIKKIINEENPVDVDRLLVVTFTNAAAQEMKNRIGEALEKVLIDEPGSQHVRKQLSLLNKASISTIHSFCLQVIRGYYYMLDVDPRFRIANQTENELLKEEVLDDILEEEYGIEDNTIFFELVDRYTSDRSDDDLQRMILALHTESRAHPNPEKWLDKLVEAYDVEGKTIEDLVYASYLLEDVKFQLETAEQHIRKATELAMLPDGPAPRIETLQADVALLGTLSSAARESWTSVYEAMQNVSWQTLKRIKKSDYNEDVVKQVDSLRNKAKDEVKKLQEELFSRKPESFLRDFQDMHPVLEKLVQLVKVFTERFQAMKRDKGMVDFTDLEHFCLQILSEQSENGEMNPSAVALQYRNKFAEVLVDEYQDTNFVQESIIKFVTKDSESEGNLFMVGDVKQSIYRFRLAEPGLFLGKYKRFTQEGLGGGMKIDLAKNFRSRHEVLAGTNFIFKQIMGEEVGEIDYDADAELKLGATYPEGEDVAAELLCIQQTEEEVIDGEEGAEVEKAQLEARLMAQRIKAMVDSGYEVYDRKNDSMRPVQYRDFVILLRSMPWAPQIMEELKLQGIPVYADLATGYFEATEVNIMMNVFRVIDNPMQDIPLAAVLRSPIVGLSDEELATLRAHGKKGSFYEVMSSFLKGAPLEEEQELHDKLEWFYNLLQGWREFARQQSLSDLIWKVYGETGYYDFVGGLPAGKQRQANLRVLYDRARQYEATSFRGLFRFLRFIERILERGDDMGTARALGEQEDVVRIMTIHKSKGLEFPVVFVAGLGRRFNTQDLMKRFLLHKDFGFGSQFIDPRKRIKYTTLSQLAIKRKMKMELIAEEMRVLYVALTRAKEKLILIGTVKDANKEMEKWLDAREHSEWLLPDHIRAGASCYLDWIAPSLYRHRDSEMLLELGQGSIPDEIYGYDTSWKVEVVDGNTLLAPEPVQEEKQELLEALREKKAVPLQSERKEEVYDRLMWKYGYEDATSHRAKQSVTEIKRNYQSEEGSDNAFIKKLRAPIKTRPRFMEKKGLTYAERGTAVHAVMQHVDLKKPITVEVLQEQIAGMVNKELLTFEQAEEIAIEKVISFFDSDLGKRVLAAKSVEREVPFTMMLAAEEAYQDWQGKSEETILVQGVIDCMIEEEDGITLIDFKTDTIEGKFPGGFEQAKPILEDRYKVQLSLYAKALEKSLQHPVKEKCLYFFDGNHVVNIEE
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
What are the official names of this protein?
ATP-dependent helicase/nuclease subunit A, ATP-dependent helicase/nuclease AddA, DNA 3'-5' helicase AddA.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddA subfamily.
Protein: UB2WA_DANRE
Sequence: MASMQKRLQKELLALQNDPPAGMTLNERSVQNTITEWFIDMEGAQGTVYEGEKFQLLFKFSSRYPFESPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPALSVQSVCLSIISMLSSCKEKRRPPDNSFYVKTCNKNPKKTKWWYHDDTC
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.  Catalyzes monoubiquitination.  Involved in degradation of misfolded chaperone substrate and DNA repair.
What are the official names of this protein?
Probable ubiquitin-conjugating enzyme E2 W-A, E2 ubiquitin-conjugating enzyme W-A, N-terminal E2 ubiquitin-conjugating enzyme, Ubiquitin carrier protein W-A, Ubiquitin-protein ligase W-A.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Nucleus.
Protein: VIAA_PECAS
Sequence: MITLESLEMLLSIDENELLDDLVVTLMATPQLAFFFEKYPSLKSALLNDLPHWKETLKQRLRTTQVPPELEREFSCYQRSQSIDNQAFQTRLPAIMDTLNNVESPFLTQASQLITSPERTLGQKVTSGLHALFLQRWRLSLTLQTVSLHQQLMNQEREILLDELQQRLTLSGKLEPILAENENAAGRLWDLSAAQRIQTDPRLLLDFGTFLQRQPALQKLAERLGRSRETKSILTQEAPQEAFRVRVREPATVPEQVSGVHQSDDILRLMPTELVTLGISELEYEFYRRLLEHRLLTYRLQGESWREKVTERPVVHQQNEQQPRGPFIVCVDTSGSMGGFNERCAKAFCLALMRIALADNRRCYIMLFSTGVVKYELTSEDGLEQAIRFLSQSFRGGTDMAACLSALLDKMDDALWHDADAVVISDFIAQRLPDEVVNKVKSRQKQLQHRFHAVAMSDHGKPGIMHIFDHIWRFDTGLKSRLMRRWQHGKAY
What are the official names of this protein?
Protein ViaA, VWA domain protein interacting with AAA ATPase.
What is the protein family that this protein belongs to?
Belongs to the ViaA family.