PharMolix/UniProtQA huggingface dataset:
Protein: KATG_HYPNA
Sequence: MDGNDLVENKCPVMHGGITVAGHSNTAWWPETLNLEILHQHDTKVSPLGKDFNYRDAVKSLDFEALKKDMHDLMTNSQDWWPADYGHYGGLMIRLAWHSAGSYRLADGRGGGNTGNIRFAPLNSWPDNGNLDKARRLLWPIKKKYGNKISWADLILLSGTIAYESMGLKTYGFSFGREDIWAPEKDVYWGAEKEWLAPSDERYTDVDKPETMENPLAAVQMGLIYVNPEGVNGKSDPLKSAAQVRETFARMAMNDEETAALTCGGHTVGKAHGNGDAGKLSPPPEGNDLETQGFGWMNPNMDGKATNAVTSGIEGAWTTHPTKWDMGYFHLLFGYEWELTKSPAGASQWRPINIKEEDMPVDPTDPTKRVMPMMTDADMAMKMDPAYNAICQKFMADQAYFSDTFARAWFKLTHRDLGPRVRYIGPDAPQEDLIWQDPVPAGSKSYDVAAVKAKIADSGLSLSEMVSTAWDSARTFRGSDLRGGANGARIRLAPQKDWAGNEPARLQKVLSVLEPIASATGASVADVIVLAGNVGVEQAAKAAGFDISVPFSPGRGDATAEMTDADSFESLEPYADGFRNWQKEDYVVKPEELLLDRAQLLGLTGPEMTVLLGGMRVMGTNHGGTKHGVFTDKVGALTNDFFVNLTDMANKWVPRGKNAYDITDRKSGAVKFTATRADLVFGSNSILRAYAEIYAQDDAKEKFVKDFVAAWSKVMDADRFDLA
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: ECI2_RAT
Sequence: MAAVTWSRARCWCPSLLQVLRLPVTKLHLGRPAMRATQQDFENAMNQVKLLKKDPGNEVKLRLYALYKQATEGPCTMPKPGVFDFVNKAKWDAWNALGSLPKETARQNYVDLVSSLSSSSEASSQGKGGADGKAQESKGILVTSEGGITKITFNRPSKKNAITFQMYQDIILALKNASTDDTVITVFTGAGDYYSSGNDLTNFTSASGGMEEAANKGAIVLREFVNTFIDFPKPLVAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNSMRISKELIRKNEKEKLHAVNEEECTTLRARWLSEECINAIMSFVTRKPKL
What is the function of this protein?
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.  Has a preference for 3-trans substrates.
What are the official names of this protein?
Enoyl-CoA delta isomerase 2, Delta(3),delta(2)-enoyl-CoA isomerase, D3,D2-enoyl-CoA isomerase, Dodecenoyl-CoA isomerase, Peroxisomal 3,2-trans-enoyl-CoA isomerase, pECI.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Peroxisome matrix. Mitochondrion.
Protein: MINE_CLOK5
Sequence: MDLFRAFSKPSSKDIAKERLRLILINDRCSMPQEVLEDIKEDILKVLSKYMEINYAEIDVRMTITEKVEEDPVALVANIPVKKVKYNK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: PUR7_BACC7
Sequence: MQKLELLYEGKAKRIYRTESADMVWVEYKDSATAFNGEKKETITGKGRLNNEITTLLFRKLQEVGIKTHFVEKLSETEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTVLAEPIVEFYFKDDDLGDPLVTEDHIRVLNVASPEQVSVLRDMALQINQVLIDHFASCRVRLVDFKLEFGVTDEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTDAYEEILKRLGGISHV
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: Y554_STRP6
Sequence: MPFIFRYSFFNKALIFWYTILMKIYKTINHIAGENTYYLVNDQAVILIDPGSNGQEIISKIKSFEKPLVAILLTHTHYDHIFSLDLVRDAFDHPPVYVSEKEAAWLSSPDDNLSGLGRHDDIINVIARPAENFFKLKQPYQLNGFEFTVLPTPGHSWGGVSFVFHSDELVVTGDALFRETIGRTDLPTSNFEDLITGIRQELFTLPNHYRVYPGHGPSTTICHEKNANPFFH
What are the official names of this protein?
Probable metallo-hydrolase M6_Spy0554.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily.
Protein: VGRG1_VIBC3
Sequence: MATLAYSIEVEGLEDETLVVRGFHGQESLSNSVFLGQACYGFRYEVQLASRVSNLTAEQMVDKRAELKLYRNSQLVQRVHGIVRAFSQGDIGHHHTFYQLTLVPALERLSLRHNSRIFQKQTVPEILSILLQEMGINDYAFALKRDGVQREFCVQYRESDIDFLHRLAAEEGLVYSFVHEAGKHTLYFSDASDSLSKLPEPIPYNALVGGAIDTPYIHGLTYRTQAEVSEVQLKDYSFKKPAYSFLQTVQGTELDYQQTRYQHFDAPGRYKDDVNGAAFSQIRLDYLRRHAHTATGQSNEPLLRAGYKFDLQEHLDPAMNRDWVVVSINHQGEQPQALQEDGGSGATTYSNQFSLIPGHLHWRAEPQPKPQVDGPMIATVVGPEGEEIFCDEHGRVKIHFPWDRYSNGNEQSSCWVRVSQGWAGSQYGFIAIPRIGHEVIVEFLNGDPDQPIITGRTYHATNTPPYTLPEHKTKTVLRTETHQGEGFNELSFEDQAGKEQIYLHAQKDFDGLIENDQFTQIKHNQHLTVEWESREAVTGEQVLSIEGSLHVKTGKVRVNEAGTEIHVKAGQKVVIEAGSEITVKAGGSFVKVDPAGVHLSGALVNLNSGGSAGSGSGFGGAMPALPGGLEPAVALAPPQTISYQALLQAEQANVPAVKVCPLAAQEATPAVNSITPPPPPPIAPPMAPPQPIMNPQPTANAQPNLGRSTKATPDFPTHFPKSSIGIENELAGLVVAMPANSAQKFGYVKSAQGDALFMLTKDMNQGSYQRPPSLQDGKNYQNWQTHTVELVSYPCEMDDKAAVETRKQAMLWLATHFTTHIDQSNHQPLAPIQSEDGRFVIEITNAKHVIAAGNGISAESQGQTITMTPSGQQATVGVAAKGFGTSATPELRLLESAPWYQKSLKSQFASLTSAENLDDKELAANVFAYLTSIYLKTAELAKKFGIYINEWDPMSEQITPNANGLTDPKVKNAWEILPRTKPSKIVEILSKSDAKAVMKHIKPQLQSRYSESLSKNVFQYFQDGGEVAGHGINNATVGDKHSPELAILFEFRTVPNELQSYLPKTESTTKSEVKLLDQFDPMKRKTVIQQVESLV
What is the function of this protein?
Part of the type VI secretion system (T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (By similarity).  Forms the spike at the tip of the elongating tube probably formed by hemolysin co-regulated protein/Hcp.  Allows the delivery of the TseL antibacterial toxin to target cells where it exerts its toxicity (By similarity).  Acts also directly as an actin-directed toxin that catalyzes the covalent cross-linking of host cytoplasmic monomeric actin.  Mediates the cross-link between 'Lys-50' of one monomer and 'Glu-270' of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:22898822).  The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:22898822).  Acts as an acid--amino-acid ligase that transfers the gamma-phosphoryl group of ATP to the 'Glu-270' actin residue, resulting in the formation of an activated acyl phosphate intermediate.  This intermediate is further hydrolyzed and the energy of hydrolysis is utilized for the formation of the amide bond between actin subunits (PubMed:22898822).
What are the official names of this protein?
Actin cross-linking toxin VgrG1.
What is the protein family that this protein belongs to?
Belongs to the VgrG protein family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm, host cytosol. Note=Secreted via the type VI secretion system.
Protein: Y024_NPVOP
Sequence: METDLAAIVHKKRALLNAAFKQQDKKIAKYFAKPCENDAEKMLMLAAEIHGQVEQLEALLSVARASDADKREFARDCSDLDIDAQDLQRMCASNEPTYFAAKYDAATVLAAHPAAYDGFLGHSERFVDAMRSLNAPNADADYLAQRKCAAIRHLCALEYLVGLHTK
What are the official names of this protein?
Uncharacterized 18.4 kDa protein.
Protein: MDTB_ECO55
Sequence: MQVLPPSSTGGPSRLFIMRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPMTQVEDMVETRVAQKISQISGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPSRAVTLSANDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKEQAIVMNVQRQPGANIISTADSIRQMLPQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMMAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAITLAVAILISAVVSLTLTPMMCARMLSQESLRKQNRFSRASEKMFDRIIAAYGQGLAKVLNHPWLTLSVALSTLLLSVLLWVFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLEERDDRVQKVIARLQTAVDKVPGVDLFLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPQLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIAKIEQRFAPLSINHLDQFPVTTISFNVPDNYSLGDAVQAIMDTEKTLNLPVDITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGILYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGIGMVGGLIVSQVLTLFTTPVIYLLFDRLALWTKSRFARHEEEA
What is the function of this protein?
The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate.
What are the official names of this protein?
Multidrug resistance protein MdtB, Multidrug transporter MdtB.
What is the protein family that this protein belongs to?
Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COPP_THEAC
Sequence: MITVVGGTFSKLHKGHKALLNTAIDTGNEVVIGLTSDEYVKKNKVYPAIPYSVRYRTLYNYMIKRTNKFRIRQIDDRNGNAPYEKDYEVIVVSPETYPRSLKINEIRISNGLPPLKIIRVPYVLAQDLFPISSTRIINGEIDTNGKRITPLKVGISTRNEAKIQAVEKFVRRLVKNYQIVKNENYNLKTQQPFGEETMELATQRAMEALKDNDYSVGIESGIIYESFSKKYYDVHYCVVIDRFGNVTRGMSSGFEIPDHIVDRMKRDRTFSEAYSGYLNVQEIDQSEGIIGKISEGKLRRIDLIEESIRNAFILRLDPDFYDSTYTPP
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Bifunctional phosphopantetheine adenylyltransferase/NTP phosphatase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the YjjX NTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_LISMF
Sequence: MKALKIALTKGRLEKDAVALLEKAGIDCSSMTDKKRKLIFHSSTQPISFILVKAVDVMTYVKHGVADIGIVGKDVLMEASKSHYEMLDLEIGKCQFCLASTPDFDPSSYRRKIIATKYPTVASKFFREKGEDVEIIKIEGSVEIAPVLGLADAIIDIVETGSTLKENGLLIYEKMYPISARLIVNKASLKQNKTQIFQLIDQLEQVIKEERAE
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_PARMW
Sequence: MPKPDIHPTWYPDAKVICNGEVVMTTGSTQPEIHVDVWSGNHPFFTGTQKILDTEGRVDRFMKKYGMGQKKSGDKAKAEAKADAKS
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: PSBC_CYACA
Sequence: MLFNKDKNNIGGRSIESTGFAWWSGNARLINLSGKLLGAHVAHAGLIVFWTGAMTLFETSHFIPEKPLYEQGMILLPHLATLGWGVAPGGEIVNTYPYFATGVIHLVSSAVLGFGGIYHSIVGPDVLEDSFSFFGYDWRDKNKMTTILGIHLILLGIGAFLLVIKALFIGGIYDTWAPGGGDIRFITNPTLNPAIIFSYLLKSPFGGEGWIVGVNNMEDVIGGHIWIGVTCVIGGIWHILTRPFSWARRAFVWSGEAYLSYSLGALALMGQTAAEYAWYNNTVYPSEFYGPTAAEASQAQAFTFLVRDQRLGANIASTQGPTGLGKYLMRSPTGEVILGGETMRFWDLRAPWLEPLRSSNGLDLNKIKNDIQPWQERRAAEYMTHAPLGSLNSVGGVATEINSVNYVSPRSWLTTSHFFLGFFIFIGHLWHAGRARAAAAGFEKGINRENEPVLSMRPLD
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP43 reaction center protein, PSII 43 kDa protein, Protein CP-43.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbC subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RUVA_STRPJ
Sequence: MYAYLKGIITKITAKYIVLETNGIGYILHVANPYAYSGQVNQEAQIYVHQVVREDAHLLYGFRSEDEKKLFLSLISVSGIGPVSALAIIAADDNAGLVQAIETKNITYLTKFPKIGKKTAQQMVLDLEGKVVVAGDGLPAKVAVQASAENQELEEAMEAMLALGYKATELKKIKKFFEGTTDTAENYIKSALKMLVK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: PUR9_SALPA
Sequence: MQQRRPVRRALLSVSDKAGIIEFAQALSARGVELLSTGGTARLLAEKGLPVTEVSDYTGFPEMMDGRVKTLHPKVHGGILGRRGQDDAIMEQHHIAPIDMVVVNLYPFAETVAREGCSLEDAVENIDIGGPTMVRSAAKNHKDVAIVVKSSDYDAIIKEMDANEGSLTLDTRFDLAIKAFEHTAAYDSMIANYFGSMVPAYHGESKEAAGRFPRTLNLNFIKKQDMRYGENSHQQAAFYIEENVKEASVATAQQVQGKALSYNNIADTDAALECVKEFNEPACVIVKHANPCGVAVSTTILDAYDRAYKTDPTSAFGGIIAFNRELDAETAQAIISRQFVEVIIAPSATEDALKITAAKQNVRVLTCGQWAQRVPGLDFKRVNGGLLVQDRDLGMVSEAELRVVSKRQPTEQELRDALFCWKVAKFVKSNAIVYAKENMTIGIGAGQMSRVYSAKIAGIKAADEGLEVKGSAMASDAFFPFRDGIDAAAAVGVSCVIQPGGSIRDDEVIAAADEHGIAMIFTDMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: Y4287_XANOP
Sequence: MDISTDNPDHGFQFPGTFELSAMGAAERGLETELPRLLAATGVELLQESVSWKHSSSGKYVSVKIGFRAESREQFDAAHQALRDHPEVKWTL
What are the official names of this protein?
UPF0250 protein PXO_04287.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: MDPC_EMENI
Sequence: MTATTHAPYRLEGKVALVTGSGRGIGAAMALELGRLGAKVVVNYANSREPAEKLVQEIKELGTDAIALQANIRNVSEIVRVMDDAVAHFGGLDIVCSNAGVVSFGHLGEVTEEEFDRVFSLNTRAQFFVAREAYRHLNTHGRIILMSSNTAKEFSVPRHSVYSGSKGAIESFVRVMAKDCGDKQITVNAVAPGGTVTDMFYDVAQHYIPNGEKHSAEELQKMAATVSPLKRNGFPVDIAKVVGFLASREAEWVNGKIITVDGGAA
What is the function of this protein?
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of monodictyphenone, a prenyl xanthone derivative (PubMed:20139316, PubMed:21351751, PubMed:22730213, PubMed:22909031, PubMed:26266881).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) mdpG (PubMed:20139316).  The atrochrysone carboxyl ACP thioesterase mdpF then breaks the thioester bond and releases the atrochrysone carboxylic acid from mdpG (PubMed:20139316).  The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodin anthrone (PubMed:20139316).  The next step is performed by the anthrone oxygenase mdpH that catalyzes the oxidation of emodinanthrone to emodin (By similarity).  Emodin is further modified to yield monodictyphenone via several steps involving mdpB, mdpC mdpJ, mdpK and mdpL (PubMed:20139316, PubMed:21351751, PubMed:22909031).  The short chain dehydrogenase mdpC converts the tautomers of emodin hydroquinone into the 3-hydroxy-3,4-dihydroan-thracen-1(2H)-one derivative (PubMed:22909031, PubMed:26266881).  These enzymes with xptA, xptB and xptC are also proposed to be involved in the synthesis of shamixanthone from emodin (PubMed:22730213).  Especially, direct reduction of emodin by the short chain dehydrogenase mdpC followed by dehydration catalyzed by the scytalone dehydratase-like protein mdpB gives loss of oxygen and formation of chrysophanol intermediate in two simple steps (PubMed:22730213).
What are the official names of this protein?
Short chain dehydrogenase mdpC, Monodictyphenone synthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: MINE_BURMS
Sequence: MSILSFLLGEKKKSAAVAKERLQLIIAHERVGGRPPADYLPALQKELVAVISKYVKISNDDIRVSLERQDDLEVLEVKIEIPQA
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: RL18_LACCB
Sequence: MISKPDKNKTRQRRHARVRGKISGTSERPRLNIFRSNKNIYAQLIDDVAGVTLASASTLDKDIKDPENKTAASAQVGALIAKRAVADGHKVVVFDRGGYLYHGRVAALAEAARENGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PP62_ASFP4
Sequence: MPSNMKQFCKISVWLQQHDPDLLEIINNLCMLGNLSAAKYKHGVTFIYPKQAKIRDEIKKHAYSNDPSQAIKTLESLILPFYIPTPAEFTGEIGSYTGVKLEVEKTEANKVILKNGEAVLVPAADFKPFPDRRLAVWIMESGSMPLEGPPYKRKKEGGGNDPPVPKHISPYTPRTRIAIEVEKAFDDCMRQNWCSVNNPYLAKSVSLLSFLSLNHPTEFIKVLPLIDFDPLVTFYLLLEPYKTHGDDFLIPETILFGPTGWNGTDLYQSAMLEFKKFFTQITRQTFMDIADSATKEVDVPICYSDPETVHSYTNHVRTEILHHNAVNKVTTPNLVVQAYNELEQTNTIRHYGPIFPESTINALRFWKKLWQDEQRFVIHGLHRTLMDQPTYETSEFAEIVRNLRFSRPGNNYINELNITSPAMYGDKHTTGDIAPNDRFAMLVAFINSTDFLYTAIPEEKVGGNETQTSSLTDLVPTRLHSFLNHNLSKLKILNRAQQTVRNILSNDCLNQLKHYVKHTGKNEILKILQE
What is the function of this protein?
Component of the core shell.
What are the official names of this protein?
Polyprotein pp62, 60 kDa polyprotein, p60, 62 kDa polyprotein, p62.
What is the protein family that this protein belongs to?
Belongs to the asfivirus polyprotein pp62 family.
What are the subcellular locations of this protein?
[Polyprotein pp62]: Host cytoplasm, host perinuclear region. Note=Found in perinuclear cytoplasmic viral factories during assembly. SUBCELLULAR LOCATION: [p35]: Virion. Note=Located in the core shell, which functions like a matrix between the DNA and the inner envelope. SUBCELLULAR LOCATION: [p15]: Virion. Note=Located in the core shell, which functions like a matrix between the DNA and the inner envelope. SUBCELLULAR LOCATION: [p8]: Virion. Note=Located in the core shell, which functions like a matrix between the DNA and the inner envelope.
Protein: HSCB_ECOL6
Sequence: MDYFTLFGLPARYQLDTQALSLRFQDLQRQYHPDKFASGSQAEQLAAVQQSATINQAWQTLRHPLMRAEYLLSLHGFDLASEQHTVRDTAFLMEQLELREELDEIEQAKDEARLESFIKRVKKMFDTRHQLMVEQLDNETWDAAADTVRKLRFLDKLRSSAEQLEEKLLDF
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA (By similarity).
What are the official names of this protein?
Co-chaperone protein HscB, Hsc20.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: RLMN_BRASO
Sequence: MATTAGLRDAAAPLEKIPLETYVPPAKPSLIGLSRAELAARLGDIGVPERQQKMRVQQLWHWLYFRGARSFDEMTSVSKDTRNGLAERFTVDRPEVVAEQISNDGTRKWLLRLPSGDDLQKAHEVECVYIPETDRGTLCVSSQVGCTLNCAFCHTGTQRLVRNLTAGEIVGQIMVARDRLNDWADRETPHGNRLITNIVMMGMGEPLYNFEAVRDALLIVSDNEGIGISRRRITLSTSGVVPNIKRAGEEIGVMLAISLHAVRDELRNELVPLNRKYPIAELLQACRDYPGASNARRITFEYVMLKGVNDSLDDARLLVKLLKGIPAKINLIPFNPWPGSAYECSDWEQIEKFSEYVFNAGYSSPVRTPRGRDILAACGQLKSETEKLSARERQALRAMAMTD
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXT_ACTPJ
Sequence: MNDYTKYTIGVLSLQGAVSEHIAQIETLGAKAIAVKSLSELQQVDALVLPGGESTAMRRLMHSSGLFQALKSFDKPILGTCAGLILLANKLEGGEPPHLAKMNIQVQRNAFGRQVDSFQTDLMIKGFADPFPAVFIRAPYISRIGSEVEVLAEWQGNVVFAKQGNLLACAFHPELTSDTRVVELFLQQLKE
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: ADIP_RAT
Sequence: MGDWMTVTDPVLCTENKNLSQYTSETKMSPSSLYSQQVLCSATPLSKNVHGVFSAFCTGENIEQSISYLDQELTTFGFPSLYEESKSKEAKRELSIVALLNCMNELLVLQRKNLLAQESVETQNLKLGSDMDHLQSCYAKLKEQLEASRREMISLQERDRQLQCKNRNLHQLLKNEKEEVQKLQNIIASRATQYNHDVKRKEREYNKLKERLHQLVMNKKDKNIAMDVLNYVGRVDGKRGSWRTDKTEARNEDEMYKILLNDYEYRQKQILLENAELKKVLQQMKKEMISLLSPQKKKPRERAEDSTGTVVISDVEDDAGELSRDGVWSLSCDTVREQLTNSIRKQWRILKSHVEKLDNQASKVHSEGFHEEDVISRQDHEQETEKLELEIERCKEMIKAQQQLLQQQLATACDDDTTSLLRDCYLLEEKERLKEEWSLFKEQKKNFERERRSFTEAAIRLGLERKAFEEERASWVKQQFLNMTTFDHQNSENVKLFSAFSGSSDPDNLIVHPRPRQKKPHSVANGVPACTSKLAKSLPTSPSDFCPSRSCVSEHSPVSALTVTPEETKPNEVGRESTDQKWSVVSRPSSREGCYGGCSSAYTSSHVERDDLP
What is the function of this protein?
Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles.  The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity).  Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity).  Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs).  May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (PubMed:12446711).  Involved in ciliogenesis (By similarity).  It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (By similarity).
What are the official names of this protein?
Afadin- and alpha-actinin-binding protein, ADIP, Afadin DIL domain-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the ADIP family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Not found at cell-matrix AJs.
Protein: Y4844_PSEA8
Sequence: MRLIIVSGRSGSGKSTALNVLEDNGFYCIDNLPASLLPDLAQRALLHTELLQPQVAVSIDARNLPSQLQRFPELLQEVRDNHINCDVLYLDADDETLLKRFSETRRRHPLTTDTRSLAEAIGDESQLLGPIADLADLKLDTTSLNLYQLRDTIKLRLLNKPEPGTAFLVESFGFKRGMPVDADLVFDVRCLPNPYWKPELRDHSGLEPEVREYLAAQPDVEEMYQDIVGYLNKWLPRFAASNRSYVTVAIGCTGGHHRSVYLAERIGAALRDSLKNVQIRHRDLSS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein PLES_48441.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: TRPC_MYCMM
Sequence: MSPATVLDSILEGVRADVAAREALVGMTEIKAAAAAAPPPLDVMAALRQPGIGVIAEVKRASPSAGSLAPITDPAKLARAYEDGGARIISVLTEGRRFQGSLDDLDAVRAAVSIPLLRKDFVVQPYQIHEARAHGADMLLLIVAALDQSALVSMLDRTESLGMTALVEVHTEQEADRALKAGAKVIGVNARDLTTLEVDRDCFARIAPGLPSNVIRIAESGVRGTNDLLAYAGAGADAVLVGEGLVKSGDPRAAVADLVTAGTHPSCPKPAR
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.