PharMolix/UniProtQA huggingface dataset:
Protein: KOJP_ECOLI
Sequence: MTRPVTLSEPHFSQHTLNKYASLMAQGNGYLGLRASHEEDYTRQTRGMYLAGLYHRAGKGEINELVNLPDVVGMEIAINGEVFSLSHEAWQRELDFASGELRRNVVWRTSNGSGYTIASRRFVSADQLPLIALEITITPLDADASVLISTGIDATQTNHGRQHLDETQVRVFGQHLMQGSYTTQDGRSDVAISCCCKVSGDVQQCYTAKERRLLQHTSAQLHAGETMTLQKLVWIDWRDDRQAALDEWGSASLRQLEMCAQQSYDQLLAASTENWRQWWQKRRITVNGGEAHDQQALDYALYHLRIMTPAHDERSSIAAKGLTGEGYKGHVFWDTEVFLLPFHLFSDPTVARSLLRYRWHNLPGAQEKARRNGWQGALFPWESARSGEEETPEFAAINIRTGLRQKVASAQAEHHLVADIAWAVIQYWQTTGDESFIAHEGMALLLETAKFWISRAVRVNDRLEIHDVIGPDEYTEHVNNNAYTSYMARYNVQQALNIARQFGCSDDAFIHRAEMFLKELWMPEIQPDGVLPQDDSFMAKPAINLAKYKAAAGKQTILLDYSRAEVNEMQILKQADVVMLNYMLPEQFSAASCLANLQFYEPRTIHDSSLSKAIHGIVAARCGLLTQSYQFWREGTEIDLGADPHSCDDGIHAAATGAIWLGAIQGFAGVSVRDGELHLNPALPEQWQQLSFPLFWQGCELQVTLDAQRIAIRTSAPVSLRLNGQLITVAEESVFCLGDFILPFNGTATKHQEDE
What is the function of this protein?
In vitro catalyzes the phosphorolysis of D-kojibiose into beta-D-glucose 1-phosphate and D-glucose.  No other disaccharides tested substitute for D-kojibiose.  In the reverse direction disaccharides can be formed from beta-D-glucose 1-phosphate plus D-glucose, L-sorbose, D-sorbitol, L-iditol or 1,5-anhydro-D-glucitol, but with low efficiency.  The beta-D-glucose 1-phosphate product is the substrate for YcjU (AC P77366), the next apparent enzyme in the putative biochemical pathway encoded in this locus (yjcM to ycjW).
What are the official names of this protein?
Kojibiose phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 65 family.
Protein: RS8_VIBC1
Sequence: MSMQDPISDMLTRVRNGQAANKVAVKMPSSKLKVAIAALLKAEGYIVDFAVEGEAKPELEVTLKYFQAKPVIEQLKRVSRPGLRVYKKKDQLPSVMGGLGIAIVSTSKGLMSDRAARKAGLGGEIICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: SYK_RICFE
Sequence: MSEIWEDAIKSNAWPFVEAKKILDSLNGKVPEKNYVLFETGYGPSGLPHIGTFGENARMVMVQKAFEQLSDISTKLICFSDDMDGLRKVPSNIPNPEMVAGYMDMPLTSIPDPFGECESYGHYMNAKLRSFLDKFGFEYEFYSSTNCYKAGMFDEMLIRVLEKYDEIMELMLPTFREERKATYSPFMPICPKTGKVLQVPIEKWDAKAGTVRYKDEAGNYVEVPVTGGHCKLQWKPDFGMRWAALKVDYEMYGKDHLANARLYSEICRILGGKPPVQLCYELFLDENGEKISKSKGNSISVDDWLKYAPVESMALFMYQNPTRAKRLFFDVIPKNVDEYITFNQKYHLEEDRAKRFANPVYHIHHGNVPKIETFGITYALLLNLTSVCNPSDKSVLWGFISKYEPKATPKTSPYLDHLAEFAIRYYNDFIKAYKSYLAPSEKHKVILQDILDMLSSISDQTEAEAIQKAIYDIGMKAGYENLRDYFKDLYQILLGQSEGPRLGTFIKLYGIKETMKLVEGKLYTR
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRAM_I63A2
Sequence: MNPNQKIITIGSASLGLVILNVILHVVSIIVTVLVLSNNGTGPNCNGTIIREYNETVRVERITQWYNTNIIEYIEEPSNEYYMSNTEPLCEAQGFAPFSKDNGIRIGSRGHVFVIREPFVSCSPLECRTFFLTQGSLLNDKHSNGTVKDRSPYRTLMSVEVGQSPNVYQARFEAVAWSATACHDGKKWMTVGVTGPDAQAVAVVHYGGVPVDVINSWAGDILRTQESSCTCIKGDCYWVMTDGPANRQAQYRIFKAKDGRIIGQTDINFNGGHIEECSCYPNEGKVECVCRDNWTGTNRPVLVISPDLSYTVGYLCAGIPTDTPRGEDSQFTGSCTSPLGSQGYGVKGFGFRQGNDVWAGRTISRTSRSGFEIIKIRNGWTQNSKDQIRKQVIVDNLNWSGYSGSFTLPVELTKKGCLVPCFWVEMIRGKPEEITIWTSSSSIVMCGVDHKVASWSWHDGAILPFDIDKM
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: DECO_BP234
Sequence: MDKVKLFQTIGRVEYWERVPRLHAYGVFALPFPMDPDVNWAQWFTGPHPRAFLVSIHKYGPKAGHVYPTNLTDEDALLNVIGMVLDGHDYENDPNVTVTLKAAVPIEYVQQDPQAPALQPHQAVLDAAEVLKLKVIKGHYFFDYTR
What is the function of this protein?
Cooperatively binds the expanded capsid, thereby stabilizing the mature capsid shell and allowing the large viral DNA to be packaged (PubMed:30737287).  Trimers of capsid decoration proteins molecules are located at local and icosahedral threefold axes and stabilize the expanded capsid, which shows increased spacing between capsomers (PubMed:30737287).
What are the official names of this protein?
Decoration protein, Auxilliary protein, Gene product 88, gp88.
What are the subcellular locations of this protein?
Virion. Note=Located between the capsid hexons.
Protein: PRIL_METJA
Sequence: MIIMLSEYLEEFKEYLERFKNIDINFSDVLKMSKKFIIWRLKQIFGDSSTIFTNISSEITIFDKIFQMIDYDIDGEVEKRLPKDESRFMIGVRREKEIEIKKEIITNLLDFLLIILLSHTPYFNAFVRKYAEIKKIKVIKKLPNKISVWEFIKIASRSRINDLHLERLDLENGFVDITKIKEIFAKEIIRVELMKLGENIKKRKLPDDSVVKELLNEISDYLKDKVKYEQISGIKALNYKGNIPLEWHPPCIRGILNDILSGGSPSHYARRSFVVYWFCAKFNPNLRPLDKNGNLVNVSATDIASEEEIERFIDELIEMLFKNVEDFDEKKTRYYIMHNIGYKVGHGRLTHCEYCKNWQDDGGKGLSYYCKPDELCKKKFIIHPLDYLCYNINKHLKKERFKKIKKEDKNGDNK
What is the function of this protein?
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.  Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability.  The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis.  May also play a role in DNA repair.
What are the official names of this protein?
DNA primase large subunit PriL.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic-type primase large subunit family.
Protein: Y1090_PEDPA
Sequence: MESWLFLIGIFIVALLGKNQSLIIASIVVLFLKLIPYSDKIFPLLNKQGINWGVTIISITILVPIATGKIGFMDLVNSFKSPVGWIAVACGILVSLLSYQGVGFLSASPEVTVALVMGTIIGVVFMNGIAAGPIIASGIAYLIIQLLQIQIK
What are the official names of this protein?
UPF0756 membrane protein PEPE_1090.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ADA1A_RAT
Sequence: MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
What is the function of this protein?
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.  Its effect is mediated by G(q) and G(11) proteins.  Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
What are the official names of this protein?
Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK- mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity).
Protein: HM40_CAEEL
Sequence: MSEASKSIMDLLSEVVKITDMTMDNEAVNKLKPQIKINPFYRAVQDVLVEQKSKIDLSTKMMKDLEAQENDERLDTMLKAEGVAGPDDSLLRIQEAAGTDQYEYRQQLLKVRRELENETKAFDKHCKKWCEYVEDVLQQQGEFRPITQQSTEKFMNKMSGKFNKVCFVLKQTACEEVIQLKKRYLDARRKRRNFSKTSTEILNEYFLANINHPYPSEEVKQALAMQCNISVAQVSNWFGNKRIRYKKTMAKNEDERRENRKPEDRPPPGAPGAPYSLVPNAFAGMMNPYQMMLPGHQFPIGVAPFNFSMYNPEMMAQYQQSLQNPNQTR
What is the function of this protein?
Plays a role in regulating gene expression in dopaminergic neurons, acting redundantly with homeobox protein ceh-20 in head neurons (PubMed:23788625).  May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-43 and ceh-20 (PubMed:23788625).
What are the official names of this protein?
Homeobox protein ceh-40.
What is the protein family that this protein belongs to?
Belongs to the TALE/PBX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CLPP_STRSL
Sequence: MIPVVIEQTSRGEASYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNNLEQILADNSGQPIEKVHVDAERDNWMSAQETLEYGFIDEIMANNQLK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR11_GUITH
Sequence: MVRQVKKSSLKKNKKVAANGVVHIQSTFNNTIVTLSTLEGDTVAWASSGAIGFKGAKKGTPFAAQIAAEKATKEAISQGMKKAEVLINGPGSGRETAIRALQAAGLEITLIRDITPVPHNGCRPPKKLRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FABH_STAAM
Sequence: MNVGIKGFGAYAPEKIIDNAYFEQFLDTSDEWISKMTGIKERHWADDDQDTSDLAYEASVKAIADAGIQPEDIDMIIVATATGDMPFPTVANMLQERLGTGKVASMDQLAACSGFMYSMITAKQYVQSGDYHNILVVGADKLSKITDLTDRSTAVLFGDGAGAVIIGEVSEGRGIISYEMGSDGTGGKHLYLDKDTGKLKMNGREVFKFAVRIMGDASTRVVEKANLTSDDIDLFIPHQANIRIMESARERLGISKDKMSVSVNKYGNTSAASIPLSIDQELKNGKLKDDDTIVLVGFGGGLTWGAMTIKWGK
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Has some substrate preference for butyryl- and isobutyryl-CoA.  Its substrate specificity determines the biosynthesis of branched-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III, SaFabH.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACHP_LYMST
Sequence: MRRNIFCLACLWIVQACLSLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEIL
What is the function of this protein?
Binds to acetylcholine.  Modulates neuronal synaptic transmission.
What are the official names of this protein?
Acetylcholine-binding protein, ACh-binding protein, AchBP.
What is the protein family that this protein belongs to?
To the extracellular portion of ligand-gated ionic channels family.
What are the subcellular locations of this protein?
Synaptic cleft. Note=Released in an acetylcholine-dependent manner in the synaptic cleft.
Protein: RPOC1_GNEPA
Sequence: MIDSQKEHQKLKITLVSPEQIRVWSETILPNGKRIGEVTNPKTIDLATNKPERNGSFCERIFGPVKSKKCACENKFGEDKKGFAFVDRKKTNDSGLCEHCGVEFMDSRIRRYRMGYIKLASPVTHIWYIKRVPSYIATLIGKQNSEIKDLVYCNLFLARPAVNKPTILRFRGLLQHGEITSWMEILVPYISGWNFVEFQERELATGGTSIQKQLIGLNLRALLNHSYMEWRKLLKNHRIQKRKNKIEKRKNFLVKRIKFAKNLIQAKINPEWMVLCLLPVLPPELRPIFVLGEQVVVESDFNKLYQKVNLRNKNLQNSFEIQGGPFYSTGDFLTLQKRLLQEAVDALLDSGKSGQPRKDHFRNRPYKSFSDVIAGKEGRFRANLLGKRVDYSARSVIVVGPSLALHQCGLPRELAIKLFQPFLIRNLIGQGVVANIRAAKLLIQRRIPVVWKILQQILLGHPVLLNRAPTLHKFGILAFQPILVKERAIRLHPAVCTGFNADFDGDQMAVHLPLSIEAILESRLLMFSHTNLLSPSNGSPITKPTQDMLLGLYILTTEKPRNISQFRCRPSNPTKKFLPEANLCFCNYDDVFIAYQKNRVSLKNPLWFRWKVVNGTILTSVDQEVPIEFQYQSLGTSQQIYEHYTIQRARSGKVLTIYIRTTVGRIIFNREIENAFLAFSKLSESPRAMPVFLNKSDTMFLMILNSCSAKQNCGKPAKRGLKYFVNSAEKILEVSLYETKKTSPFLQ
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PUR7_THEVO
Sequence: MKLLTTGKVKDVYDDGDTLVFKFSNRISVFDKIIPNEIDNKGESLCRTSAFWFQLIESYGMKSHFIELIDNRTMRVRKFAVPNKVSLGSSNYVIPLEFITRYYVAGSLYDRIKEGKVKPMDIGLKHVPEYGEKLIDPIFEATTKREETDRLLTKKEAMEIGGLTLEDYCEIMEAVFKIDRRIDMEVSKRGLIHADGKKEIALDRERRIVVVDTFGTADEDRFWDEKEYDNGRVVELSKEMVRQYYRSIGYHDKLYYARENGLPEPDIPALSDDMVSKVSDLYRMMFEKITGQKW
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: UBA1_SCHPO
Sequence: MSNNMNIDQTDQNTIDEGLYSRQLYVLGHEAMKQMSQSNVLIIGCKGLGVEIAKNVCLAGVKSVTLYDPQPTRIEDLSSQYFLTEDDIGVPRAKVTVSKLAELNQYVPVSVVDELSTEYLKNFKCVVVTETSLTKQLEINDFTHKNHIAYIAADSRGLFGSIFCDFGENFICTDTDGNEPLTGMIASITDDGVVTMLEETRHGLENGDFVKFTEVKGMPGLNDGTPRKVEVKGPYTFSIGSVKDLGSAGYNGVFTQVKVPTKISFKSLRESLKDPEYVYPDFGKMMRPPQYHIAFQALSAFADAHEGSLPRPRNDIDAAEFFEFCKKIASTLQFDVELDEKLIKEISYQARGDLVAMSAFLGGAVAQEVLKATTSKFYPLKQYFYFDSLESLPSSVTISEETCKPRGCRYDGQIAVFGSEFQEKIASLSTFLVGAGAIGCEMLKNWAMMGVATGESGHISVTDMDSIEKSNLNRQFLFRPRDVGKLKSECASTAVSIMNPSLTGKITSYQERVGPESEGIFGDEFFEKLSLVTNALDNVEARMYVDRRCVFFEKPLLESGTLGTKGNTQVVVPHLTESYGSSQDPPEKSFPICTLKNFPNRIEHTIAWARDLFEGLFKQPIDNVNMYLSSPNFLETSLKTSSNPREVLENIRDYLVTEKPLSFEECIMWARLQFDKFFNNNIQQLLFNFPKDSVTSTGQPFWSGPKRAPTPLSFDIHNREHFDFIVAAASLYAFNYGLKSETDPAIYERVLAGYNPPPFAPKSGIKIQVNENEEAPETAANKDKQELKSIADSLPPPSSLVGFRLTPAEFEKDDDSNHHIDFITAASNLRAMNYDITPADRFKTKFVAGKIVPAMCTSTAVVSGLVCLELVKLVDGKKKIEEYKNGFFNLAIGLFTFSDPIASPKMKVNGKEIDKIWDRYNLPDCTLQELIDYFQKEEGLEVTMLSSGVSLLYANFQPPKKLAERLPLKISELVEQITKKKLEPFRKHLVLEICCDDANGEDVEVPFICIKL
What is the function of this protein?
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system.  Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.
What are the official names of this protein?
Ubiquitin-activating enzyme E1 1, Poly(A)+ RNA transport protein 3.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-activating E1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ZN404_HUMAN
Sequence: MARVPLTFSDVAIDFSQEEWEYLNSDQRDLYRDVMLENYTNLVSLDFNFTTESNKLSSEKRNYEVNAYHQETWKRNKTFNLMRFIFRTDPQYTIEFGRQQRPKVGCFSQMIFKKHKSLPLHKRNNTREKSYECKEYKKGFRKYLHLTEHLRDHTGVIPYECNECGKAFVVFQHFIRHRKIHTDLKPYECNGCEKAFRFYSQLIQHQIIHTGMKPYECKQCGKAFRRHSHLTEHQKIHVGLKPFECKECGETFRLYRHMCLHQKIHHGVKPYKCKECGKAFGHRSSLYQHKKIHSGEKPYKCEQCEKAFVRSYLLVEHQRSHTGEKPHECMECGKAFGKGSSLLKHKRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEKPHECKECGKTFKLHSYLIQHQIIHTDLKPYECKQCGKAFSRVGDLKTHQSIHAGEKPYECKECGKTFRLNSQLIYHQTIHTGLKPYVCKECKKAFRSISGLSQHKRIHTGEKPYECKECDKAFNRSDRLTQHETIHTGVKPQKCKECGKAFSHCYQLSQHQRFHHGERLLM
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 404.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MAP1_STAAR
Sequence: MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).  Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Protein: RS6_RICTY
Sequence: MSFYESVFIIRQDVSLNDIDKIVDDFTKIIKDNDGTIIKKEYWGLRTLAYKIGNNKKGHYYFLGIDITSNIKEELERKMKLNESIIRFLTIKVDSISSEPSPILKNQSTENTPVIDVTINN
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RL10_XYLFT
Sequence: MALNVFQKQEVVKELAGVATKAHSLIVAEYAGITVPQMTAMRKQARESGVYLKVVKNKLAARALGDTEYAVIKEKLIGPLLYAFSLEDPGAAGRLIKEFSKKHDKLKSKAVSLGGVLYPAGHVDVLASLPTRLQALAMLARVLSEPVTLFARAIKAMADDKSETFAVSSPETSEA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: ENV_HV2ST
Sequence: MCGRNQLFVASLLASACLIYCVQYVTVFYGVPVWRNASIPLFCATKNRDTWGTIQCLPDNDDYQEIALNVTEAFDAWNNTVTEQAVEDVWSLFETSIKPCVKLTPLCVAMRCNSTTAKNTTSTPTTTTTANTTIGENSSCIRTDNCTGLGEEEMVDCQFNMTGLERDKKKLYNETWYSKDVVCESNDTKKEKTCYMNHCNTSVITESCDKHYWDTMRFRYCAPPGFALLRCNDTNYSGFEPNCSKVVAATCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTIISLNKFYNLTVHCKRPGNKTVVPITLMSGLVFHSQPINRRPRQAWCWFKGEWKEAMKEVKLTLAKHPRYKGTNDTEKIRFIAPGERSDPEVAYMWTNCRGEFLYCNMTWFLNWVENRTNQTQHNYVPCHIKQIINTWHKVGKNVYLPPREGQLTCNSTVTSIIANIDGGENQTNITFSAEVAELYRLELGDYKLIEVTPIGFAPTPVKRYSSAPVRNKRGVFVLGFLGFLTTAGAAMGAASLTLSAQSRTLLAGIVQQQQQLLDVVKRQQEMLRLTVWGTKNLQARVTAIEKYLKDQAQLNSWGCAFRQVCHTTVPWVNDTLTPDWNNMTWQEWEQRIRNLEANISESLEQAQIQQEKNMYELQKLNSWDVFGNWFDLTSWIKYIQYGVYIVVGIIVLRIVIYVVQMLSRLRKGYRPVFSSPPAYFQQIHIHKDREQPAREETEEDVGNSVGDNWWPWPIRYIHFLIRQLIRLLNRLYNICRDLLSRSFQTLQLISQSLRRALTAVRDWLRFNTAYLQYGGEWIQEAFRAFARATGETLTNAWRGFWGTLGQIGRGILAVPRRIRQGAEIALL
What is the function of this protein?
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers.  Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells.  Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells.  This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: MGN_CHICK
Sequence: MASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
What is the function of this protein?
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.  The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism.  The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD) (By similarity).
What are the official names of this protein?
Protein mago nashi homolog.
What is the protein family that this protein belongs to?
Belongs to the mago nashi family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Protein: SRP19_STAMF
Sequence: MSRDYKGKKIVIYPQYIDSSIPRSRGRRIPRNIAIPKPRIEEIIEAAEELGLNPKYEESAYPKHWWIKGRIVVDKVGSKLNTLKLIAQKIKDLRK
What is the function of this protein?
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane.  Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
What are the official names of this protein?
Signal recognition particle 19 kDa protein, SRP19.
What is the protein family that this protein belongs to?
Belongs to the SRP19 family.
What are the subcellular locations of this protein?
Cytoplasm.