PharMolix/UniProtQA huggingface dataset:
Protein: DEF6_PANTR
Sequence: MRTLTILTAVLLVALQAKAEPLQAEDEPLQAKAYEADAQEQRGANDQDFAVSFAEDASSSLRALGSTRAFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL
What is the function of this protein?
Host-defense peptide that contributes to intestinal innate immunity and mediates homeostasis at mucosal surfaces by forming higher-order oligomers that capture bacteria and prevent microbial invasion of the epithelium (By similarity).  After binding to bacterial surface proteins, undergoes ordered self-assembly to form fibril-like nanonets that surround and entangle bacteria and thereby prevent bacterial invasion across the epithelial barrier (By similarity).  Entangles and agglutinates Gram-negative bacteria, such as E. coli, S. typhimurium and Y. enterocolitica, and Gram-positive bacteria such as L. monocytogenes, thereby protecting the intestine against invasion by enteric bacterial pathogens (By similarity).  Blocks adhesion of C. albicans to intestinal epithelial cells and thereby suppresses fungal invasion of epithelial cells and biofilm formation (By similarity).  Under reducing conditions and in an acidic environment similar to the intestinal milieu, exhibits inhibitory activity against anaerobic bacteria such as B. adolescentis, L. acidophilus, and B. breve, as well as B. longum and S. thermophilus, possibly by leading to alterations in bacterial cell envelope structures (By similarity).  The disulfide-linked oxidized form exhibits negligible antimicrobial activity against Gram-negative and Gram-positive bacteria, as compared to the enteric defensin DEFA5 (By similarity).
What are the official names of this protein?
Defensin-6, Defensin, alpha 6.
What is the protein family that this protein belongs to?
Belongs to the alpha-defensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored as propeptide in secretory granules of small intestinal Paneth cells and found in the ileum lumen as mature peptide.
Protein: ATPB_CAMC1
Sequence: MKGVISQVMGPVVDVDFNDYLPKINEAIEVFFEVEGKKHKLILEVAAHLGDNRVRTIAMDMSEGLTRGLEAKALGAPISVPVGEKVLGRIFNVVGDLIDEGEGINFDKHWSIHRDPPPFEEQSTKSEIFETGIKVVDLLAPYAKGGKVGLFGGAGVGKTVIIMELIHNVAFKHSGYSVFAGVGERTREGNDLYHEMKESNVLDKVALCYGQMNEPPGARNRIALTGLTMAEYFRDEMGLDVLMFIDNIFRFSQSGAEMSALLGRIPSAVGYQPTLASEMGKFQERITSTKKGSITSVQAVYVPADDLTDPAPATVFAHLDATTVLNRSIAEKGIYPAVDPLDSTSRMLDPQILGADHYKVARGVQAVLQKYKDLQDIIAILGMDELSEEDKLTVDRARKIERFLSQPFFVAEVFTGSPGKYVSLDENIAGFKGILEGKYDHLPEAAFYMVGNIDEALAKAEKLKA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NARG_BACSU
Sequence: MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRWQYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGASFSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKGGFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPMLSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEARYKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEYAKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGTMGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLPIKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKEAVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGWAHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPIAASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQLQEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDSIRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFIHPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQPFGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSIADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENITNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPWRTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKWSVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHRIPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYYGPTGNQRDLNVVIRKLKEVDWLED
What is the function of this protein?
The alpha chain is the actual site of nitrate reduction.
What are the official names of this protein?
Nitrate reductase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LKB14_MANHA
Sequence: MEANHQRNDLGLVALTMLAQYHNISLNPEEIKHKFDLDGKGLSLTSWLLAAKSLALKAKHIKKEISRLHLVNLPALVWQDNGKHFLLVKVDTDNNRYLTYNLEQDAPQILSQDEFEACYQGQLILVTSRASVVGQLAKFDFTWFIPAVIKYRKIFLETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNIITVALAIVIIFEIVLSGLRTYVFSHSTSRIDVELGAKLFRHLLSLPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSFIFFAVMWYYSPKLTLVILGSLPCYILWSIFISPILRRRLDDKFARSADNQAFLVESVTAINMIKAMAVAPQMTDTWDKQLASYVSSSFRVTVLATIGQQGVQLIQKTVMVINLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTEQYQGKLSLPEIKGDISFKNIRFRYKPDAPTILNNVNLEIRQGEVIGIVGRSGSGKSTLTKLLQRFYIPENGQVLIDGHDLALADPNWLRRQIGVVLQDNVLLNRSIRENIALSDPGMPMERVIYAAKLAGAHDFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMQNMQKICQGRTVILIAHRLSTVKNADRIIVMEKGEIVEQGKHHELLQNSNGLYSYLHQLQLN
What is the function of this protein?
Part of the ABC transporter complex LktBD involved in leukotoxin export.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable).
What are the official names of this protein?
Leukotoxin translocation ATP-binding protein LktB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GSH1_SHEON
Sequence: MKPFNELVQHFSDAQGRAALLGMLRGIEREALRIDESGYLALDGHPLELGSALTHSRITTDYSEALLEFITPVNHQVESLLQGLTETHAYSVRHLHGQRLWPVSMPCYVKDEANIPIARYGTSNTGKMKTLYRKGLTYRYGALMQIISGVHFNFSVSQELWQSLYELSDKSLSFDDFISESYFGLIRNYRRLVWVLPYLFGASPALCNSFIKGQKTDLRFEKSGRGTLYLPYATSLRMSDLGYTNKEQADLNISYNSLPEYLAGIRAAIKMPSANFANIGVKVDGEYRQLNANVLQIENEFYSPIRAKRVTKSGEKPSEALARAGVEYIEVRALDVNPFSPIGIEASQVRFLDLFLLYCLLTPSPKSDAAEEARLSANLKSVVLEGRKPGLELHTATGTLSLQTWLLELFDNLSSLAVLLDGETNAYQAALAHWRDAVVDPQKTLSGQVLQQLVTKGQDHGQWVMSLAQQYHQYFIDYPLSSEAASDYDAEAQSSLAKQVELEAAQSAVSLDDYLTDYFGAPA
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: MNME_STRP6
Sequence: MSITKEFDTITAISTPLGEGAIGIVRLSGTDALAIAQSVFKGKNLEQVASHTINYGHIIDPKTGTIIDEVMVSVMLAPKTFTRENVVEINTHGGIAVTNEILQLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMTIAVKQLDGSLSQLINDTRQEILNTLAQVEVNIDYPEYDDVEEMTTALLREKTQEFQSLLENLLRTAKRGKILREGLSTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNIKGVPLKLVDTAGIRETDDLVEQIGVERSKKALQESDLVLLVLNASEKLTDQDRALLNLSQDSNRIILLNKTDLEQKIELEQLPDDYIPISVLTNQNINLIEDRINQLFFDNAGLVEQDATYLSNARHISLIEKAVQSLEAVNDGLALGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBA2_NEUCR
Sequence: MREIISLNVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAADPDHGFSTFFSETGNGKYVPRTIYADLEPNVIDEVRTGAYRGLFHPEHMISGKEDASNNYARGHYTVGKELIDQVLDKVRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHADCSFMVDNEAIYDICRRNLGLERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISAAKAAHEANSVQEMTMSCFEPNNQMVKCDPRHGKYMATCLLYRGDVVPNDAHAAVATLKTKRTIQFVDWCPTGFKLGICYQPPHQVPNGDLAKVNRAVCMLSNTTAIAEAWSALSSKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSMEGEDVEAEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-B chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: UVRB_LEGPA
Sequence: MKDLFKIYSNYQPAGDQPTAIASLIDGLESGLAKQTLLGVTGSGKTFTIAHVIQAMKRPTLIMAPNKTLAAQLYGEFKAFFPDNAVEYFVSYYDYYQPEAYVPASDTFIEKDASINEHIEQMRLSATKALIERKDAIIVATVSAIYGLGDPDSYLRMLLHLSRGEQSDQRKILKRLAEMQYTRTNLSLERGQFRVHGDVIDIFPADSEKEAIRIELFDDEVDNIARFDPLTGEILQRLPRVTIFPKTHYVTPRERILETVEKVKVELQERLAELNAQNKLVEAQRLEQRTCFDIEMMLELGYCSGIENYSRYLSNREAGEAPPTLFDYLPPEALLIIDESHVTVPQIGGMYRGDRARKETLVNYGFRLPSALDNRPLRFEEFEERSPQTIYISATPGPYEQEHSDNVAEQVVRPTGLIDPEVEIRPVKTQVDDLMSEIRQVIAQGSRILVTTLTKRMAEDLTEYLSEHGIKVRYLHSDVDTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVALVAILDADKEGFLRSERSLIQTIGRAARNVKGRAILYADTMTGSMQRALTETERRREKQKAFNLKHGITPKGINKSVEDILEGAYIGKRKTMVAEQAPRYTHWSPQELAKEINALEKQMYAHAQNMEFELAAKIRDEYLLLKEQLMKI
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALF_ENCCU
Sequence: MMDCDHLLRLGMTAKKILENGKGILAADETPKTLGRRFEKLGITNTEENRRKFREILFSTKGIERYIGGVILNQETFEQTSGSGVPLTELLKKKGIEIGIKLDKGLIDYKEKEKISVGLEDLDLRCKSSAFKDATFAKWRSLFYFYDGIPSEDCINENCSILAKYAIICQKNGLVPIVEPEVFLEGDYSMKRSYEVTRQILSTLMKYLNYELVYIPGVLIKASYVTSGQLSNEKYTPKKVATFTLRALLSTIPCGIPGIVFLSGGHGSEDAIGFLNAINMERGCRTWSLSFSFARALTDGVLETWRGDDSNIEEAQKILLETSFKACRGAEGKLWDQE
What are the official names of this protein?
Fructose-bisphosphate aldolase.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
Protein: HPRK_BACAN
Sequence: MPKVRTKDLIEQFQLELISGEEGIHRPIDTSDLSRPGIEMAGFFTYYPADRVQLLGKTELTFFDTLTSDQKQERMKALCTEETPCIIVTRNQDVPDELLQASRESGMPLLRSSQTTTRLSSRLTNYLEGKLAPTTAVHGVLVDIYGVGVLITGQSGVGKSETALELVKRGHRLVADDSVEIRQEDEDMLVGSSPDLIEHLLEIRGLGIINVMTLFGAGAVRNYKRITLVINLEIWDQKKNYDRLGLDEEKMKIIDTELTKITLPVRPGRNLAVIIEVAAMNFRLKRMGVNAAQQFSERLMSAIELGNQE
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).  The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc. ) in the growth medium.  Also phosphorylates/dephosphorylates the HPr-like catabolite repression protein crh on a specific serine residue.  Therefore, by controlling the phosphorylation state of HPr and crh, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: PGLD_CAMJE
Sequence: MARTEKIYIYGASGHGLVCEDVAKNMGYKECIFLDDFKGMKFESTLPKYDFFIAIGNNEIRKKIYQKISENGFKIVNLIHKSALISPSAIVEENAGILIMPYVVINAKAKIEKGVILNTSSVIEHECVIGEFSHVSVGAKCAGNVKIGKNCFLGINSCVLPNLSLADDSILGGGATLVKNQDEKGVFVGVPAKRM
What is the function of this protein?
Acetyltransferase that modifies the UDP-4-amino-sugar to form UDP-N,N'-diacetylbacillosamine in the N-linked protein glycosylation pathway.
What are the official names of this protein?
UDP-N-acetylbacillosamine N-acetyltransferase, Protein glycosylation D, UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: RBFA_BREBN
Sequence: MNKTRISRVGEEIKKELSLVLQRGLKDPRVGFVTVTDVEVSSDLQLAKVFVSIFGSEEERKASLAGLTKAKGYLRTEIGKRVKLRHIPDFVFKLDESIDYGSKIESILREISTEGEKQDES
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CC115_MOUSE
Sequence: MAVQALREELDSKCLQLLSDLEELEAKRAALNARVEEGWLSLAKARYAMGAKSVGPLQYASRMEPQVCVRASEAQDGPQTFRVIKADAQTPEEVGPSEASLRRRKGPTKTKELGSAVVPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQTRINWGQSQLRGLQKKLKELDPGPA
What is the function of this protein?
Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis.  In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.  Necessary for endolysosomal acidification and lysosomal degradation (By similarity).  May be involved in Golgi homeostasis (By similarity).
What are the official names of this protein?
Coiled-coil domain-containing protein 115, Coiled-coil protein 1, Ccp1.
What are the subcellular locations of this protein?
Endosome. Lysosome. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle, COPI- coated vesicle. Endoplasmic reticulum. Note=Seems not to be associated with recycling endosomes.
Protein: G3P_BOLED
Sequence: LENPEINITAVNDPFIDLDYMVYMFKYDSVHGRFEGEVSTKDGKLVINGKAITVFAERDPANIPWGTVGAQYVVESTGVFTTIEKASAHLKGGAKKVIISAPSSDAPMFVCGVNLDAYDPKHTVISNASCTTNCLAPLAKVVNDKFGIVEGLMTTVHATTATQKTVDGPSPKDWRGGRAVNNNIIPSSTGAAKAVGKVIPVLNGKLTGLAFRVPTLDVSVVDLVVRLAKPTSYEEIKTAFKEASESSELKGIVAYTEDAVVSTDFLGHHASSIFDATGGIMLNDSFVKLIA
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_ACTP2
Sequence: MTQDLSKHTPMMAQYLQLKAQNPDILLFYRMGDFYELFYDDAKKAAALLDISLTKRGASAGEPIPMAGVPYHAVEGYLAKLVSLGESVAICEQIGDPATSKGPVERKVVRIVTPGTVSDEALLPERQDNLVAAIYEEKGVFAIATLDMTSGRFLITELPNKEALAAELQRLLPAEILYAEDFSAAEILNNYKGLRRRPVWEFELVTAINLLNRQFGTQSLAGFGVEKAVVALCAAGCVLHYAQETQRTALPHINSIHLAQNSDTILLDAATRRNLELTQNLAGGTENTLAAVLDKCVTPMGSRLLKRWIHQPIRDLEKLKKRQDIIDTLQKEQRIEPLQPLLQNVGDMERILARVALRSARPRDLTHLRTALAQLPDIAKNAKNLTASLDALVAQIGDFSELHALLKRAIIETPPQLIRDGGVIAEGYNAELDEWRELSAGATQYLENLEIREREATGIDTLKIGFNAVHGYYIQISQGQAHKAPMHYVRRQTLKNAERYIIPELKTYEDKVLKAKGASLALEKQLYDELFDLLMPRLGEMQLAAMALSELDVLTNLAERAESLNYVRPTFSLQRGVNIKGGRHPVVEQVLKDPFIANPVFLNAQRHLLVVTGPNMGGKSTYMRQIALISLMAYIGSFVPADSAEIGALDRIFTRIGASDDLASGRSTFMVEMTEMANILHQATEKSLVLIDEIGRGTSTYDGLSLAWACAEWLAKKTQSLTLFATHYFELTSLPSQLKGVANVHLDAREHQDSIVFMHSVQEGAASKSYGLAVAALAGVPKQVIQLAKQRLAHLEEISLQTKEAHDNPQGDLLFAADLQETPQIQPLVAQQSELEKALISIDPDELTPRQALEALYRLKKLMA
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: DNAG_METMJ
Sequence: MYSPDTTKYLIHLILQIEGVVDKPDVVGAIFGQTEGLLGEDLDLRDLQRTGRVGRIDVQITTKRGETKGVILISSSLDRAETALLASSLETIDRVGPCTAHVRVDRIEDIRVTKRRKIVERAKELLLEDFDEGSINSDDLLDEVREAIRIEKLEYLGEEKVHAGPNVIDSDAIIIVEGRADVINLLRYGIKNAVAVEGTNVPRIIIDLCSQKTATTLLDGDRGGELILRELLQVAEIDFVAYSPRGKSVEEMSRKEIVKALRNKVPAVGIIDQPPAEENVERLPPSAAPAEVRAPAGAGRTSEGERPPRREWDSKPPSTLGEHMADVRDKKIARFLSPDYTVLLESNATDVEGALQNLNGDVEGLVVDRIIDQKLLDQLGGRDIEFVAARDFKGIIKRPLSIRLIKIG
What is the function of this protein?
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
What are the official names of this protein?
DNA primase DnaG.
What is the protein family that this protein belongs to?
Belongs to the archaeal DnaG primase family.
Protein: LPXD_PROM9
Sequence: MLLSDLVDLIKKGNSNFISSNIFEDLNIEDAASLDEAVNHQISFLEENNILKEKLDKSNASAIITSNNNEIISALKKLNISNIIVKNPRIAFAEVLNHLYKTINFNPGIHASAVIDKTAIIGADCHIGPNVYIGENTVIGNNNDILTGSSILGNVRIGDNNIIHPNCVVYENTTLKNNCVINSNSVIGSEGFGFIPKDDKWVKMPQKGGVKIMSFVEIGTNCCIDRPAVGITFIDEGTKLDNLVQIGHGVKIGKNCAFAAQVGIAGGAKIGDRVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGKVISGFPAMENKSWLRSSSIFKKLPELAKKLRQLDKQ
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: RL28_WOLSU
Sequence: MARKCFFTGKGPMVGNNVSHANNKTKKRSLPNLRTVRVKLEDGTTVKLRVAASTLRTMKKRS
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: VG31_BPT4
Sequence: MSEVQQLPIRAVGEYVILVSEPAQAGDEEVTESGLIIGKRVQGEVPELCVVHSVGPDVPEGFCEVGDLTSLPVGQIRNVPHPFVALGLKQPKEIKQKFVTCHYKAIPCLYK
What is the function of this protein?
Essential for proper capsid assembly.  In absence of Gp31 the major capsid protein (Gp23) assembles into 'lumps'.  Acts as a co-chaperonin with the host groEL protein.
What are the official names of this protein?
Capsid assembly protein Gp31.
Protein: PIMB_MYCS2
Sequence: MLLVTNDFPPRRGGIQSYLEAFVGELVRTHELTVYAPKWKGAEEYDEKAARSGYRVVRHPTTLMLPEPTVASRMKRLIGEHDIETVWFGAAAPLALLGPLARRAGARRIVASTHGHEVGWSMLPVARTALRRIGNDADVVTFVSRYTRSRFASAFGPSAALEHLPPGVDTDRFAPDPDARARMRERYGLGDRPVVVCLSRLVPRKGQDMLIRALPELRRRVPDTALAIVGGGPYLETLQRMASDLGVAEHVVFTRGIPAEELPAHHAMADVFAMPCRTRGAGLDVEGLGIVYLEASACGVPVVAGRSGGAPETVLDGKTGTVVDGTDVDAITTAVGDLLADPRRAAAMGVAGRHWALDNWQWRTRGARLAELLSGRREARQA
What is the function of this protein?
Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM) (PubMed:10531370, PubMed:19638342).  Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 6 of a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1) to generate phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2) (PubMed:19638342).  PimB also catalyzes the addition of a mannosyl residue from GDP-Man to the position 6 of phosphatidyl-myo-inositol bearing an acylated alpha-1,2-linked mannose residue (Ac1PIM1) to generate monoacylated phosphatidyl-myo-inositol bearing alpha-1,2- and alpha-1,6-linked mannose residues (Ac1PIM2) (PubMed:19638342).  The addition of the second mannosyl residue by PimB preferentially occurs before the acylation of the mannosyl residue transferred by PimA.  Also able to transfer a mannosyl residue from GDP-Man to the position 6 of a phosphatidyl-myo-inositol (PI), but this reaction is very slow (PubMed:19638342).
What are the official names of this protein?
GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase, Alpha-D-mannose-alpha-(1-6)-phosphatidylmyo-inositol-mannosyltransferase, Alpha-mannosyltransferase, Alpha-ManT, Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase, Phosphatidylinositol alpha-mannosyltransferase, PI alpha-mannosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: FUMC_BORPA
Sequence: MKTRTEKDTFGPIEVPEQHLWGAQTQRSLHFFAISTEKMPVPLVAAMARLKRAAAKVNAELGELDPQVADAIMRAADEVVAGKWPDEFPLSVWQTGSGTQSNMNMNEVLANRASELLGGERGEGRKVHPNDHVNRGQSSNDTFPTAMHVAAAVEVEHRVLPALKALRGTLAAKSAAFYDIVKIGRTHLQDATPLTLGQEISGYVAQLDLAEQQIRATLAGLHQLAIGGTAVGTGLNAHPQFSAKVSAELAHDTGSAFVSAPNKFQALASHEALLFAHGALKTLAAGLMKIANDVRWLASGPRSGLGEISIPENEPGSSIMPGKVNPTQCEAVTMLAAQVMGNDVAINVGGASGNFELNVFKPLVIHNFLQSVRLLADGMVSFDKHCAAGIEPNRERITELVERSLMLVTALNPHIGYDKAAQIAKKAHKENLSLKEAALALGHLTEAQFAEWVVPGDMTNARR
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y454_THEP1
Sequence: MSGHNKWANIKHRKMAQDAKKSKIFTKLIREIIVAAREGGGNIETNPRLRAAVEKARAENMPKENIERAIKRGTGELEGVDYQEVIYEGYAPGGVAVYIRALTDNKNRTAQELRHLFNKYGGSLAESGSVSWIFERKGVIEIPRDKVKDLEELMMIAIDAGAEDIKDTEDPIQIITTPENLSEVKSKLEEAGYEVEAKVTFIPKNTMKVTGKDAEKVLEFLNALEDMDDVQEVYSNFEMDDKEMEEILSRLEG
What are the official names of this protein?
Probable transcriptional regulatory protein Tpet_0454.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_VIBVU
Sequence: MTLDISKYPTLALAETPDELRLLPKETLPTLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRREQMPTIRQKGGLHPFPWREESEYDTLSVGHSSTSISAALGMAICAEKEGQNRKVVSVIGDGAITAGMAFEAMNHAGDVHSDMLVILNDNEMSISENVGALNNHLARVLSGNLYTSIREGGKKVLSGVPPIKELVRRTEEHLKGMVVPGTLFEELGFNYIGPIDGHDVVELVKTLKNMRELKGPQFLHIMTKKGKGYEPAEKDPIGYHGVPKFDPAHNSLPKSSGGKPSFSNIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYPEQYFDVAIAEQHAVTLATGMAIGGYNPIVAIYSTFLQRGYDQLIHDVAIMNLPVMFAIDRAGLVGADGQTHQGAFDLSYMRCIPNMVIMAPSDENECRQMLYTGHKHQGPSAVRYPRGNGMGTPIESEFTALEIGKGRLVRQGEKVAILSFGTFLANALEAAEALNATVADMRFVKPLDEALLRQLANEHDVLITIEENAIAGGAGAGVIEFMMQEKIMKPVLNLGLPDKFIHQGTQEELHEELGLDAKGIEQAIRHYLAK
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.