Protein: OPAA_ASPUT
Sequence: MAIGNDELLASHEEHSRCQFPRLVANPSEEKCLRCNLDVPIRNLLKEACAQYETSLDYVLGAIWAIILHQYIQDDYVGFAVVRRTRTGEAEAEFTDSAERSYSWRTPIHGEMAIGELIKPSTWKRSPYAPGVDLFNTSLVIEEEQQQEQTNTGHHVLKEPFQISLLVKCWPDSPVISLVFSSSYLHPTFGKALASSIEQCARGILSCHDSLVNQMNLFSPIQREIMTRWQGVPSLTSHFNFLYEIVCHNAQHHPSVVALDAWDGRWSYQELDEATSRLAARLVTHGVGPGVFVPVCFDKSCWAVVAMLAINKAGAAFVPIDPSYPAERRQMIILTVAASVILTSQQHLNLFPPSPEVMTICLSPSILSDSPASGYPRRMRFEGPAYVLFTSGSTGEPKGCEISHQAFASLVNHTEDLHLTPESRTLQFASYSFGMSVIEIFCTLVAGGTVCIPSAEQRLNDLATAIKTMEINWAILTPTVIASLYPEDLPHLRFVLVAGEISDQSAVDQWAAAGVDIRHAYGLTEWTGIFAVSHKISGQGTGQTTIGKPVDAHAWLVNTQNPAQLVPLGAPGELVIKGPGLARGYLHDPLRTKASFLSDLPWLAEWKLAHGQVYRTGDIMRYHVDGSLVYLHRKDNQIKIRGLRVELGEIESHLTRILKGAKRVAVIACKPKGSHDLHVLIALILLPHVADGQLLAIGRRSKGLPFVQLPGKTREELRDARESLRRWLPDYMIPQFLLPLVDMPTTVSGKIDRRRIRTLLNELSVKELMNHAGVQVEHRLPVTANEIVVHEVTCKSLGLDLVSMQDSFFDLAGDSVAAMKMSGLARQHGLQLTVKDIFEAPILQDMATRLTRIKELTVTAIPFALLPNVVPSQIVAEIAEQAKVDPLEITDAYPCSALQEGLCALSMRDAQSYKVRLICHIRPGTDLQVFRAAWERTYLINDVLRTRFVTSSTHGAIQAVIQRPFRWDEAESFEQYVTLIEQEPMGLGKQLVRACLLRDPRSQHQQTAFVLTLHHGICDRWSIRQLLEQIDRQVHAFPKQLELDPIEFRPFISYITETASKSAEYWENQFQDIKAVIFPELPAPDYTPVADQLTQYDIKLPTRLVREISIANYIRLAWALVLAHNTSSDDVVFGAIVSGRASPVKGIVTLTGPTIATVPIRINLSREMTVLQALTSVERQFIEMLPWEQAGLQNIRRLSPEADRACSFQSLFTVQPFLGNPPPLFSACEEGAAIAGGFASYALNIECYISEDERRMQAKVAFDPRVIALGRVRRLLEHLQVVLNEVAAQTERRLSSISPLSPSDMSLLWEWNKSVPPKPKELLHEIIQSHAQKTPKSPAVSAFDGELTFEELEWHATQLAGELLQQVPHPGMLLPMLFEKSVWVTVAMLAVLKIGSAIVLLDGSYSIERMRTICADVEAPLVVCSSQMTSTVEQIGLRPVIVAHTRAFFSKSASPVSLPPVRVHSDSPCYMIFTSGSTGMPKGLLVNHGAFAASMLGWMPKLQVDKSSRVLQFSSFAFDACFAETFTALFAGACICVPSDDQRMNDLHAAMRQHRISHAILTPSSARVVRAEQVPSLRVLALVGEPILPSDMAYWAPRVRLLNGYGPAECAPASVVQYIDGSPALDVRDIGHPVGCVAWVCDPRDSEILKPVGVAGELLIEGPNVGLGYFKDAAKTDSAFVQPRWLQSLRGMTGVRAYRSSDLVCYTEDGRLRYLGRIGNQVKLRGQRLDPTHIEHQLARCFPGATEVAVVVGCPRNASDRPTLAAFVVVDKKANGNGSTDFHDVPTKDVANRAATARARMQQVLPGYMVPTLMIPVSSLPCSAAGKLDRRALENEIASRTWKELSQYESANESSTNRTPLDTERDLQGIWAKVLDLPMEAVGLRQSFFALGGDSITAMLVVAEARGRRVGLNITVDDIFRFRTIEQIAAQAATRAATIQQLCSHDVLDVPFKLTPIQQLFFRTQGQKVRHRFNHNVLLHLTQRIPYHRLESAMKTIVTAHPMLRARFVPGTAGLDWKQNIPSNIEGTFRCKHQTNGTMARILADGQRSLNITAGPVFSADLIDTEERQTILLVAHHLVVDLVSWTVILNDLDELLCGDPISGHTSTSFQTWSRLLDEYVRGQARAARLPDAQPWDGIEGFWGISQEQMTFGSCEDTTVQIERETTDLLLGDVNKTFGTQPVEVLHAALLFAFIQAFPKRPPPATYSEAHGREPWDATTDLTRTVGWFTTLAPVLLQLDSASELSEAVGQVKDARRRLTRNGLDAFTNRQQAGVMEIVFNYGGRYSQQLQKAGALFEVQSFQTLNIFDTGLDVRRWSVVDINSFVQDGKLTFVFTHPCGPSQTRIISEWTLHLMKTLKTLATDFSSASRIYTPMDFPLLKTDKAQLERLLSSLSWISPASDIENLYPCAPIQRGILLSQEKERSHYHVTMLWEIQIAGGVSASVPKAKDAIHQVITCHPCLRTSFVRSFSERALYDQVVTHNASPQIEVVHNPSKGWQGRPSAKGSPLTPEFPNRFTIHVDQEQRVYIRLDVTHALVDAMSFSLIQRDLCLAYEGRLNISSGPPYANFIAYLQSRNEEEDRVFWEEELEGIQPCLFPSLTDYQVGEVDDALSWSVELQHSEEIYAYCRAHSVTPANIFCLAWSLVLRSYVGSDDVCFGVLASGRELPFEGAQDVVGPLINVLTFRNRLKENLSVGECLQQVHTKYLRYLQHQTYPLADISHQKGDAVLFNTALSIQRVMVSADTPTSTSLNLVHRRDPVEYAIAINVDMEPSRIAVHLRYWLSSLSSEMAMLIASSFEQAVHQIITNDQLHPAQLDLVSTDHKRLLHRWNSTLPAFDEAPIHETIQQHVRETPDALAVRWSKGSFTYRELGLLSDRLGGHLRRQGVAPGAFVPLCFDKSPWTVVALLAVIKSGAAFALCDVTHPDSRLRSICQDLQSTVILCSPDQETRCKKIAEKAIVVGEHNNSWKGDTVGPPTPELSVRAPLFVVYTSGSTGKPKGVLIEHRSFCALVHYQISVWGMSPAARVMQFASYAFDASVFEILFPLMRGTCTCILTEVERRDYLDATMKRLRVTHAFLTPSVARQLSPAAVPDLQVLVCGGEPLSHQDINQWTVNVRLVEAYGPAECTVFSACQPSLTPASCPSDIGRPVGCVVWLVDPDDTERLMPVGSLGEILIEGPIVGRGYINNSQATESSFIKPPAWLRAIRPDLDPTTRLYKTGDLARYFPDGRLDIHGRKDSQIKIRGQRIELGEVEFQVQSRFKLAVGVVVDVAPTGPNGSTALCAFICFGGRVSPSEVDSQVLRAADEDFAAEAASASAALFECLPAYMVPSYFFPLANLPVNASGKADRRYLKSLVDIPAEQLNQYRPLSNRQQRLPSTAGEQLLHNIWSTALGLDGKLIGADDSFFQVGGDSVSAMKVAAAARQQGLEISVADIFAHPRLSALAARSRSKDASDSGFDPTPFSLCPPGAKVLLPMLLRARNMLPPKSTIIDILPVSEGQGFFLTRVALHHFSFAVEGKLDIERIRHACETVYLFFAILRTIFIHWHGQILQLVLDNIEVPFHHILTDSDPAEVHRELRDLDRKVASVLDEQPPCAFILISDRSGTRHELIFRLSHTQWDGLSLAELFSAFGSAYHNRPIPPTTPLTTVVYHRLMRNKTKSLSFWRDYLRGSTISSLIPSAPETTDLSPGTTIWENTNLQPAPEPPSGITMASVVKAAWALVIAQEKGRGCRDIVFGQTVNGRSSALPNIERIFGCCLNFIPVRIRVREEMSIYDLLRHTQAQYQETVAHDDVGFQSIVDESTDWPRGTYFNSIVQHQNIPLHHVMPLEDLKTHFTLNGYFRPGREVIIFTEPDGDVLSVQFCANPNVIEFSYAQKLHRTLVDLIVHLCRCPDDLVSTLLVE
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of oxepinamides, derivatives of anthranilyl-containing tripeptides that share an oxepin ring and a fused pyrimidinone moiety (PubMed:33004788).  The nonribosomal peptide synthetase (NRPS) opaA assembles the quinazolinone core with D-Phe incorporation (PubMed:33004788).  The first adenylation domain (A1) of opaA loads and activates anthranilic acid whereas the second A domain (A2) is for activating of L-Phe, which is then converted to D-form by the E domain (PubMed:33004788).  The third A domain (A3) is responsible for L-Ile activation and the terminal condensation domain C3 for cyclization and releasing the NRPS product protuboxepin K (PubMed:33004788).  The cytochrome P450 monooxygenase opaB then catalyzes alone the oxepin ring formation to convert protuboxepin K into protuboxepin A (PubMed:33004788).  The flavoenzyme opaC installs subsequently one hydroxyl group at the oxepin ring, accompanied by double bond migration, to form 15-epi-oxepinamide E (PubMed:33004788).  The epimerase opaE changes the D-Phe residue back to L-form, leading to oxepinamide E, which is further methylated at the hydroxyl group at C-12 by the O-methyltransferase OpaF to yield oxepinamide F (PubMed:33004788).
What are the official names of this protein?
Nonribosomal peptide synthetase opaA, Oxepinamide F biosynthesis cluster protein A, Quinazolinone synthase opaA.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.