PharMolix/UniProtQA huggingface dataset:
Protein: DTD_BIFLD
Sequence: MKVVLQRVSEASVDVVNELGTLDPTFEPQQIGPGFMILVGVTDEDGDKQIAWLAHKILNLRVFEDAQGKMNRSIQDIGGEILSISQFTLFADVHKGNRPSFIKAGKPEHADFMWIKFDEALRSGGVPVKEGRFGAHMRVGLVNDGPVTIVIDTEHDMPDGTR
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPIN_CBEPV
Sequence: MNKLILISLIASLYQVEVDAHGYMTFPIARQRRCSAAGGNWYPVGGGGIQDPMCRAAYQNVFNKVLNSNGGDVIDASEAANYMYTQDNEYAALAGPDYTNICHIQQRVVPSYLCAAGASDWSIRPFGDKSGMDLPGSWTPTIIQLSDNQQSNVVMELEFCPTAVHDPSYYEVYITNPSFNVYTDNVVWANLDLIYNNTVTLRPKLPESTCAANSMVYRFEVSIPVRPSQFVLYVRWQRIDPVGEGFYNCVDMKFKYSEGPDEEDIIEPEYEVDNEAECFAYRTNSGNVNVNPLQENKYMAYANKAIRNINTHSNGCSRNRNNKNNYNKYYSKTYNYNQNRK
What is the function of this protein?
This protein is a spindle body protein.
What are the official names of this protein?
Spindolin, Spheroidin, p50.
Protein: Y450_MYCGE
Sequence: MRIAFLVDSVSNLKEDKNSHLYVLPLYIIETIAEHQETFKSGFNIDLKTLTDKMINAPKGVKFSTSQTSEEEVRDKVKSIINDYDLIIGIPIDKEISTSYLNWKIVEKEFEDKFHVLDSRIVEVLIAWLISDIKVWLKNNQYSRAGLDEFVYNFRNKCGAILFVTDTKPLVAGGRLSNLKSFIIKSFKFHLLISFLGETGKLQFFNKAQSASSAHKLAVQFLEKKLLKKEVNFRRAALLTTMFETDKNQLIKQEFVTLLNNAVDVSEHLLSPVICTHTGINSYAFLIQTE
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein MG450.
Protein: SFSA_ECOSM
Sequence: MEFSPPLQRATLIQRYKRFLADVITPDGRELTLHCPNTGAMTGCATPGDTVWYSTSDNTKRKYPHTWELTQSQSGAFICVNTLWANRLTKEAILNESISELSGYSSLKSEVKYGAERSRIDFMLQADSRPDCYIEVKSVTLAENEQGYFPDAVTERGQKHLRELMSVAAEGQRAVIFFAVLHSAITRFSPARHIDEKYAQLLSEAQQRGVEILAYKAELSAEGMALKKSLPVTL
What is the function of this protein?
Binds to DNA non-specifically.  Could be a regulatory factor involved in maltose metabolism.
What are the official names of this protein?
Sugar fermentation stimulation protein A.
What is the protein family that this protein belongs to?
Belongs to the SfsA family.
Protein: RL16_BACTN
Sequence: MLQPKKTKFRRQQKGRAKGNAQRGNQLAFGSFGIKALETKWITGRQIEAARIAVTRYMQRQGQIWIRIFPDKPITRKPADVRMGKGKGAPEGFVAPVTPGRIIIEAEGVSYEIAKEALRLAAQKLPITTKFVVRRDYDIQNQNA
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: HPS5_DROPS
Sequence: MADEYCLTNFIDFSLSLSLPLKHNRIKYTCFDISDSYIIFGASSGSLYLFNRNGKFLHLIPNKHGAITNLSISANNKYVAFSTQRSLICVYVVNLSAQATPQVIVTHLDQSVQVSCIHWTQDEKQFYYGDSRGQVNLVLLSSFIGHSLLLNMTVHPLLYLDSPIVQIDDFESLLLVSNCTKCILCNTEYEEYKQIGNRPRDGAYGACFFISPHESVQPSRIYCARPGTRIWEVDFEGEVIQTHQFKTALATAPAKIQKTTNVDNNADELDSNDELLDYQPQQLQFSRVQRLSHDFLLAYTELGLYIFDVRNSSVVLWCNQFERILDCRVSGMEIFVFTQTGSLYSVQLQTLHGYSITLMHQSKLLQCANLLRQHVKYFADKARENYELKLLNQLKQLLIERQEYELLNDISVIFDAIAQCTGTALDTQSSGGSSAATERSGSMRAIGVSTTKGPPKGVYVLENAFCDNLKQQPKSGHFKDALLTVTGKFGKNIIKYKFNIFAEEQQQLVRELIPASERSLPFKDIKARYESGDVGEEEIVSRCKRPTPQAPHISPEEKTIYNLYLICKSAKFSRTHCVERYRAVFDEYAASELIALMGKLAQLMVEHGDGQEQAERNCYEMYFNYLNPELIWEVDDSTRDYIASGFVLLNAPQCMEIVRCDHCAFPLRFDNACQYHELGAVLLRYFWSRNEQLKCFDVVQAVPALLDVLAKFYLAEQNLDKVIPIVLNYGQPELLLDVGRQLNVSAWARCFEQFAELQRGRLICVNCECVSSVEQDQLTRHFFYTWNCFLNIALDHLTASDTLSLIFKWSSYIPNDAIDREFYSRCLIKG
What is the function of this protein?
Has a role in the biogenesis of eye pigment granules.  Eye pigment granules are specialized forms of late endosomes or lysosomes.  Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes (By similarity).
What are the official names of this protein?
BLOC-2 complex member HPS5 homolog, Hermansky-Pudlak syndrome 5 protein homolog, Protein pink.
What is the protein family that this protein belongs to?
Belongs to the HPS5 family.
Protein: VSIG2_HUMAN
Sequence: MAELPGPFLCGALLGFLCLSGLAVEVKVPTEPLSTPLGKTAELTCTYSTSVGDSFALEWSFVQPGKPISESHPILYFTNGHLYPTGSKSKRVSLLQNPPTVGVATLKLTDVHPSDTGTYLCQVNNPPDFYTNGLGLINLTVLVPPSNPLCSQSGQTSVGGSTALRCSSSEGAPKPVYNWVRLGTFPTPSPGSMVQDEVSGQLILTNLSLTSSGTYRCVATNQMGSASCELTLSVTEPSQGRVAGALIGVLLGVLLLSVAAFCLVRFQKERGKKPKETYGGSDLREDAIAPGISEHTCMRADSSKGFLERPSSASTVTTTKSKLPMVV
What are the official names of this protein?
V-set and immunoglobulin domain-containing protein 2, Cortical thymocyte-like protein, CT-like protein.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GLRX2_ECOLI
Sequence: MKLYIYDHCPYCLKARMIFGLKNIPVELHVLLNDDAETPTRMVGQKQVPILQKDDSRYMPESMDIVHYVDKLDGKPLLTGKRSPAIEEWLRKVNGYANKLLLPRFAKSAFDEFSTPAARKYFVDKKEASAGNFADLLAHSDGLIKNISDDLRALDKLIVKPNAVNGELSEDDIQLFPLLRNLTLVAGINWPSRVADYRDNMAKQTQINLLSSMAI
What is the function of this protein?
Involved in reducing some disulfide bonds in a coupled system with glutathione reductase.  Does not act as hydrogen donor for ribonucleotide reductase.
What are the official names of this protein?
Glutaredoxin 2, Grx2.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
Protein: GLPK1_SULAC
Sequence: MSKYILAVDEGTTSARALVFDEDLNVISIAQTELTQYFPRPGYVEQNPEEIFEKQVSMIKKAVEKAKIEISQVSAIGIANQRETTIMWDSRSGRPVYNAVVWQDRRTSDITDWLKSNYLNLFKSKTGLIPDPYFSASKIKWILDNVPGVREKAERGEIKFGTVDTYLIWKLTNGKVHVTDYSNASRTMLFNIKKLEWDRDILEILEIPEAILPEVRSSSEVYGYAEPVGNIPISGDAGDQQAALFGQLGFSKGDVKCTYGTGSFILMNSGEEIYDSKDLLTTIAWKIGKDVKYALEGSIFTTGAAVQWVRDGLGLVSSSDEIESLASSVVDNGGVYFVPAFSGLGSPYWDPYARGLIIGISRGTSRGHIARAVLESIAYQVRDVIEVIKKDVGKEFVNVLKVDGGVSKNNLLMQFQADILGIRIVRPRVIETTSMGASMLAGLAVDYWSSLEELKSKWAVDREFIPSLQEDRRERLYKGWKEAVRRTIGWAREVETME
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase 1, ATP:glycerol 3-phosphotransferase 1, Glycerokinase 1, GK 1.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: PLSX_CLOB6
Sequence: MIIAVDGMGGDFAPELVVEGCIQAVKEYEGIHIIITGKKELIKNELDKREYKGNKIEILNAEEVISTNEAPVKAIRRKKDSSMVKALELVKEGKAQAVISAGSTGALMAGATFVLGRIKGINRVCLAPLLPGAKAPFMIADAGANVDCKAEYLVQFAMMGKVYFESVLGVKSPTVGLVNIGAEEEKGNELTKAAYKLLKDTDFNFIGNIEPRDIPRGEVNIAVCDGFIGNTVLKTYEGVASNLFSMLKKEIMASTRGKIGGALLKPVFKDFKKKFDYTEYGGSPFLGAKGICIKAHGSSDAKAFKNAIRQAKICYDKKIIEEIENNLGNLIENNI
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: FA83B_MOUSE
Sequence: MEASSMLSSLNDECRSDNYVEPHYKEWYRVAVDTLIEHGLEAYQEFLIKERVSDFLAEEEINYILKNVQKIAQNTEHGSDSSCDDGSSSGTYWPMQSDVEAPNLDLGWPYVMPGLLGSTHIDLLFHPPRAHLLTIKETIRKMIKEARKVVAIVMDVFTDVDIFKEIVEASTRGISVYILLDESNFSHFLTMTEKQGCQIQRLRNIRIRTVKGQDYLSKTGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGHLVELFDEEFRTLYARSSVPSSFAQEESVRAKPGKALWENGIYQRSISSLASVSSQRNLFGRQDQIHKLDSSYFKGRGIYPLNDQDKHSMRNHGYKPHFVPNFNGPSTIRHFQPSQLNENWKRHSYAGEQPETTPYLLLNRAMNRTNNAPGRWRRPSDSLSVASSLRGGQGSQQNIPAQSFADRLAQRKTTNLAERNSNVRRSFNGTDNHIRFIQQRMPTLENTTKSFLRSWRIESYLNDNSEVPPDSNGSTLGDRFEGYENPEAVKANALYTHSRLRSSFVFKPTLPEQKEVNSCTTGSSNSTIIGSQGSDTPNEVPDTSTNAPPLTEKPLPEPSSKLPTQQEEPKMHNLQVPEKQPEALNQRTNGRAELNNCIYTNLCVNKQRENTENQQNDNLLKRRSFPSFDHSKVNLEHGNSKNYVYSTLTRNRIRQPEKPKEVVLKSSKSMHNVTHSAEEDDDEVIERDPPSASATKSISIAALLDVNKEEPNKEPNSKKEGKASPSFLKKGSQKLRSLLSLTPEKRESLAKNKAPAFYRMCSSSDTLVSEGEENQKPKKSEPKVDSSPRRKRSSSSNSQGSIHKSKEDIAVSASPGISSQAEESRRIAPSPRPVERRLSERAGDASAPRFNTEQIQYRDSKEISSLMTPARRPTPSPVLKPNELLRSHSTNQRVYSRFEPFCKIESSIQPASSVTNTHVNRPEVKSSTMGTAYGRSSPMLNYKTGAYHSYAPNENKFRGFMQKFGNFIHKNK
What is the function of this protein?
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway.  Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.
What are the official names of this protein?
Protein FAM83B.
What is the protein family that this protein belongs to?
Belongs to the FAM83 family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane.
Protein: CBPS_YEAST
Sequence: MIALPVEKAPRKSLWQRHRAFISGIVALIIIGTFFLTSGLHPAPPHEAKRPHHGKGPMHSPKCEKIEPLSPSFKHSVDTILHDPAFRNSSIEKLSNAVRIPTVVQDKNPNPADDPDFYKHFYELHDYFEKTFPNIHKHLKLEKVNELGLLYTWEGSDPDLKPLLLMAHQDVVPVNNETLSSWKFPPFSGHYDPETDFVWGRGSNDCKNLLIAEFEAIEQLLIDGFKPNRTIVMSLGFDEEASGTLGAASLASFLHERYGDDGIYSIIDEGEGIMEVDKDVFVATPINAEKGYVDFEVSILGHGGHSSVPPDHTTIGIASELITEFEANPFDYEFEFDNPIYGLLTCAAEHSKSLSKDVKKTILGAPFCPRRKDKLVEYISNQSHLRSLIRTTQAVDIINGGVKANALPETTRFLINHRINLHSSVAEVFERNIEYAKKIAEKYGYGLSKNGDDYIIPETELGHIDITLLRELEPAPLSPSSGPVWDILAGTIQDVFENGVLQNNEEFYVTTGLFSGNTDTKYYWNLSKNIYRFVGSIIDIDLLKTLHSVNEHVDVPGHLSAIAFVYEYIVNVNEYA
What is the function of this protein?
Necessary for use of certain peptides as sole nitrogen source.  May also cleave intracellularly generated peptides to recycle amino acids for protein synthesis.
What are the official names of this protein?
Carboxypeptidase S, GLY-X carboxypeptidase, YSCS.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: VM32A_GLOBR
Sequence: QQRYLNAKRYVKLAIVADRSMVTKHNGKLKKLRKWIYRIVNTINEVYRSLNILVALVYLEIWSKEDLINVTSAAKDTLASFGNWRATDLLKRRSHDAAHLLTNIKFDGTTVGKAYVASMCQQDSSVGINQDHSKINLLVALTMAHELGHNLGMSHDVVNTEKQCNCGTCVMAPTISDQISKLFSNCSKNDYENFLTLYKPQCILNEPSKTDIVSPPVCGNELLEVGEECDCGSPETCQNPCCDAATCKLTSGSQCAKGLCCDQCKFSKSGTECRAAKDDCDIAESCTGQSADCPTDDLQRNGKPCQNNAGYCYNGKCPIMLNQCISFYGSNATVAPDICFNYNLKGEGNFYCRKEQATIFPCAQKDKKCGRLFCVLGPTGKRISCKNTYSEDDPNYGMVDLGTKCEDGKVCNSNRECVDVNTAY
What is the function of this protein?
Non-hemorrhagic metalloproteinase that degrades fibrinogen.  The alpha chain (FGA) is rapidly degraded, the beta chain (FGB) is degraded very slowly, while the gamma chain is left intact.  Shows a prefential cleavage at X-Leu bonds.  Cleaves insulin B chain at '29-His-|-Leu-30', '33-Ser-|-His-34', '38-Ala-|-Leu-39' and '40-Tyr-|-Leu-41' bonds.
What are the official names of this protein?
Zinc metalloproteinase-disintegrin-like brevilysin H2a, Snake venom metalloproteinase, SVMP.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: STK4_HUMAN
Sequence: METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
What is the function of this protein?
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.  Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.  The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.  Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.  STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity).  Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.  Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.  Phosphorylates MOBKL1A, MOBKL1B and RASSF2.  Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).  Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner.  Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage.  Acts as an inhibitor of PKB/AKT1.  Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
What are the official names of this protein?
Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.
Protein: FHI1B_PONAB
Sequence: MERMNWLSRLASRGPGHRIPQGANLQTPVMADPETCLMVFKNHWSQVVRILERQGPRAAPGGADDLSAVRNHTYQMLTLLAEDRAVPSAPTGPGPLLEFAPHEDLLTRVLTWQLQWGELGDGVEERRAEQLKLFEMLVSEARQPLLQHGPVREALLTLLDACGRPVPSSPALDEGLVLLLSQLCVCVAQEPSLLEFFLQPPPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALPLLMALSAGSPTVGRYIADHSYFCPVLATGLSALYSSLPRRIEVPGDDWHCLRREDWLGVPALALFMSSLEFCNAVIQVAHPLVQKQLVDYIHNGFLVPVMGPALHKTSVEEMIASTAYLELFLRSISEPALLRTFLRFLLLHRHDTHTILDTLVARIGSNSRLCMVSLSLFRTLLNLSCEDVLLQLVLRYLVPCNHVMLSQKPAVRDVDLYGRAADKFLSLIPRCCRHHAPSPPRPEHASWARGPGSPSVDSSSVMTVPRPSTPSRLALFLRQQSLSGSESPGPAPCSPGLSASPASSPGRRPTPAEEAGELEDNYLEYQREARRGVDHCVRACRTWSAPYDGERPSPEPSPFGSRTKKRSLLPEEDRNNVGEGEEEELGSRGLAGGAGEGPGHLPPPQLNGVPGSWPEGAKRVRLVPKEGVGELLEGISEGMAGLEGFGQELRELEVALSNGGTGSESPLEPPLPLEEEEAYESFTCPPEPPGPFLNSPLRTPNQLPSQPFTGPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQPSVKSLLQVLGSVKNKIENFAASQEDFPALLSKAKKYLIARGKLDWAEGPAAGPAPRRSDPLVKSRRPSLGELLLRHARSPTRARQAAQLVLQPGRDGAGLGLSGGSPGASTPVLPTRGGAPERQGEALRVKNAVYCAVIFPEFLKELAAISQAHAVTSPFLLETSEEGSGPLISGCGPLNP
What is the function of this protein?
Component of the FTS/Hook/FHIP complex (FHF complex).  The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).  FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
What are the official names of this protein?
FHF complex subunit HOOK-interacting protein 1B, FHIP1B, FTS- and Hook-interacting protein, FHIP.
What is the protein family that this protein belongs to?
Belongs to the FHIP family.
Protein: NS1BP_XENLA
Sequence: MIPNGSLNFEDEQFIESSVAKLNALRKSGQFCDVKLQVCGHEMLAHRAVLACCSPFLFEIFNSDSESNGISLVRFDDLNPEAVEVLLNYAYTSQLKAETDLVKDVYSAAKKLKIDRVKQVCGDYLISKIDAQSGISCRNFVNTMGDWRLLTKIDNYIQEHLLEISEQDDFLKLPRLNLEIMLEENVSLPSNGKLYTKVINWVQRSIWENGENLDALMEEVQTLYYSADHKLLDGSSLGEHTEAHEDNIQLIQKKSPRENNHKNLISSSSGSLSPSALIQCPKHEWKIIASEKKTNNTYLCLAVLNSTLCVIFLHGRNSPVNSPSSTPRLTKSLSLEIQPEDSLERVMSPMHYARSGLGTAELNGKLIAAGGYNREECLRTVECYDLETDIWTFIAPMKTPRARFQMAVLMDHLYVVGGSNGHSDDLSCGEKYDPKSNIWTPVPELRSNRCNAGVCALNGNLYVVGGSDPYGQKGLKNCDVFNPITRMWTCCAQLNIRRHQPAVCELGNKIYIIGGAESWNCLNSVECYNPQNDTWTLVAPMNVARRGSGVAVYDGKLLVVGGFDGTHALCCVESYNPERNEWKMVGSMTSSRSNAGVVAVGNQIYAAGGFDGNEFLNTVEVYNPQTDEWSPFTQLCES
What is the function of this protein?
Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats.
What are the official names of this protein?
Influenza virus NS1A-binding protein homolog, NS1-BP, NS1-binding protein homolog.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Associated with actin filaments.
Protein: AR6P4_CHICK
Sequence: MARGRSRKRSRSSSRSPSGSGREKGGARSSAASPGPRHRLSSAAAREGRKKEGRKKKKRKAKASSSDRSSSSRSSSSSSSTSSSDSDTRAKQHSRRKRGKHKDKKKKKKMKKKLKKKSKERVKEERGVSEALPGPSLELWQKEPLADSGPVLTDEQKSRIQAMKPMTKEEWDARQSVIRRVVDPETGRTRLIKGDGEVLEEIVSKERHKEINKQATRGDGLAFQVRTGMLK
What is the function of this protein?
May be involved in modulating alternative pre-mRNA splicing.
What are the official names of this protein?
ADP-ribosylation factor-like protein 6-interacting protein 4, ARL-6-interacting protein 4, Aip-4.
What is the protein family that this protein belongs to?
Belongs to the ARL6IP4 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus speckle.
Protein: SNF5_MOUSE
Sequence: MMMMALSKTFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHGKKTKPNTKDHGYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRRMRRLANTAPAW
What is the function of this protein?
Core component of the BAF (SWI/SNF) complex.  This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation.  The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal.  This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers.  Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A.  Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.  Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).  During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.  The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.  As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).  The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.  The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
What are the official names of this protein?
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, BRG1-associated factor 47, BAF47, Integrase interactor 1 protein, SNF5 homolog, mSNF5.
What is the protein family that this protein belongs to?
Belongs to the SNF5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HMDH_DROME
Sequence: MIGRLFRAHGEFCASHPWEVIVALLTITACMLTVDKNNTLDASSGLGTATASAAAAGGSGSGAGSGASGTIPPSSMGGSATSSRHRPCHGWSQSCDGLEAEYNAADVILMTIVRCTAVLYCYYQFCSLHRLGSKYVLGIAGLFTVFSSFIFTTAIIKFLGSDISELKDALFFLLLVIDLSNSGRLAQLALSGSNQAEVTQNIARGLELLGPAISLDTIVEVLLVGVGTLSGVQRLEVLCMFAVLSVLVNYVVFMTFYPACLSLIFDLSRSGVDMSVVREKAKGSLLLKSLTEEEQKANPVLQRVKLIMTTGLMAVHIYSRVAFSGSDYDAVDKTLTPTLSLNVSNNRTESGEIADIIIKWLTMSADHIVISIVLIALVVKFICFDNRDPLPDQLRQSGPVAIAAKASQTTPIDEEHVEQEKDTENSAAVRTLLFTIEDQSSANASTQTDLLPLRHRLVGPIKPPRPVQECLDILNSTEEGSGPAALSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSVRGVRSVVEDVGMTRAPCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFVAITGDAMGMNMVSKGAEMALRRIQLQFPDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRSSIAVNSANNPLNVTVSSCSTIS
What is the function of this protein?
Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation.  Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm.  Also required for association of the pole cells with the gonadal mesoderm.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PSUG_FRAAA
Sequence: MAGRSNIVVSATVRDALAAGAPVVALESTLIAHGLPRPRNRDVAVELEELARARGVTPATIAVIDGVPRVGLDEPDLRRIADDANVIKLSVRDLPVACATGWTGATTVASTALLAARVGIRLFATGGLGGVHRGAGDSFDESADLVTLAAMPITVVSAGVKSILDIGATLERLETLGITVVGYRTSTFPGFYLPHTTYDLDWRVGDAGQVAATMAAADLLGLTSAIVVANPLPTDQALDPALHDRVLADALAWATERGIRGKAVTPFLLETFHRETGGASLEVNINAVRNNVAVASDIALAWAAKDRSPTDPAAPDPTAPDPAAPDPTAPDPAAPDSAAPDLAGPDPSAPDPAAVARAHRP
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: RUVC_SHIBS
Sequence: MAIILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.