PharMolix/UniProtQA huggingface dataset:
Protein: SYY_DESHD
Sequence: MNILDDLKARGLVYQTTDEEALYKRLESPMTLYCGFDPTADSLHIGHLLPVLMLRRFQLAGHCPIALVGGGTGLIGDPSGKTSERTLNPTEVVQEWANRIKEQLSCFLDFEGVGNPAIMANNYEWLGTINVIEFLRDIGKNFSLGSMLAKESVESRMSRGISFTEFSYQILQSYDFLKLNELYGCEMQIGGSDQWGNITSGTDLIRRMSVGEDRQVHGLTVPLVTKSDGTKFGKTEGGAVWLDPDKTSPYKFYQFWINTDDRDVVKYLNFFTFLSIEEIQGLAQEVESQPEKRNAQRMLAKEVTELVHGVEARERAEKISQALFTGGIANLTAKEVEEGFSDVPSADVEDQEMLLVDALIKVGAVSSRRQARESMESGAVYVNGIRQTDTTLTVAQLDKIESRFIVIRRGKKNYYLVKLV
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WAPI_BACSU
Sequence: MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDFSAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDYKESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP
What is the function of this protein?
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  Neutralizes the tRNase activity of cognate toxin WapA upon expression in E. coli.  Does not inhibit WapA from other strains of B. subtilis.  The WapA C-terminus cannot be expressed on its own in E. coli, however it can be cloned in the presence of its cognate immunity protein gene.  Cell contact is necessary for growth inhibition (PubMed:23572593).  Unlike the LXG toxin-immunity modules, WapAI mediates competition under shaking culture conditions (PubMed:34280190).
What are the official names of this protein?
Immunity protein WapI.
Protein: ERPA_NEIG1
Sequence: MSDESPIIFTDSCCAKVADLIAEENNPDLKLRVFVNGGGCSGFQYGFTFDEIKNDDDFEIEKNGLVFLVDPMSYQYLVGAEIDYTESLQGSQFVIRNPNAETTCGCGSSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters.
What are the official names of this protein?
Putative iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: IRG1_MOUSE
Sequence: MMLKSVTESFAGMIHGLKVNHLTDGIIRRSKRMILDSLGVGFLGTGTEVFHKVTQYSKIYSSNTSSTVWGRPDFRLPPTYAAFVNGVAVHSMDFDDTWHPATHPSGAVLPVLTALSEALPQIPKFSGLDLLLAFNVGIEVQGRLMHFSKEAKDIPKRFHPPSVVGTLGSAAAASKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPLHIGNAAKHGMEATFLAMLGLQGNKQILDLGSGFGAFYANYSPEDLPSLDSHIWLLDQQDVAFKSFPAHLATHWVADAAAAVRKHLVTPERALFPADHIERIVLRIPDVQYVNRPFPDSEHEARHSFQYVACASLLDGSITVPSFHSQQVNRPQVRELLKKVKLEHPPDNPPSFDTLYCEISITLKDGTTFTERSDTFYGHWRKPLSQEDLRNKFRANASKMLCRDTVESLITVVEKLEDLEDCSVLTRLLKGPSVQDEASKLSSMSSFDHTTLPRFTNI
What is the function of this protein?
Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:30635240, PubMed:31548418).  Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450).  Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396).  Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (PubMed:30635240).  Plays a role in the embryo implantation (PubMed:14500577).
What are the official names of this protein?
Cis-aconitate decarboxylase, CAD, Aconitate decarboxylase, Aconitate decarboxylase 1, Cis-aconitic acid decarboxylase, Immune-responsive gene 1 protein.
What is the protein family that this protein belongs to?
Belongs to the PrpD family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LGUL_CICAR
Sequence: MAASESKESPANNPGLHTTIDEATKGYFMQQTMFRIKDPKVSLDFYSRVLGMSLLKRLDFPEMKFSLYFMGYEDTTEAPSNPVDRTVWTFAQKATIELTHNWGTESDPEFKGYHNGNSDPRGFGHIGITVDDTYKACERFQNLGVEFVKKPDDGKMKGIAFIKDPDGYWIELFDRKTIGNVTEGNA
What is the function of this protein?
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
What are the official names of this protein?
Lactoylglutathione lyase, Aldoketomutase, Glyoxalase I, Glx I, Ketone-aldehyde mutase, Methylglyoxalase, S-D-lactoylglutathione methylglyoxal lyase.
What is the protein family that this protein belongs to?
Belongs to the glyoxalase I family.
Protein: GP_SFTSV
Sequence: MMKVIWFSSLICLVIQCSGDSGPIICAGPIHSNKSAGIPHLLGYSEKICQIDRLIHVSSWLRNHSQFQGYVGQRGGRSQVSYYPAENSYSRWSGLLSPCDADWLGMLVVKKAKESDMIVPGPSYKGKVFFERPTFDGYVGWGCGSGKSRTESGELCSSDSGTSSGLLPSDRVLWIGDVACQPMTPIPEETFLELKSFSQSEFPDICKIDGIVFNQCEGESLPQPFDVAWMDVGHSHKIIMREHKTKWVQESSSKDFVCYKEGTGPCSESEEKACKTSGSCRGDMQFCKVAGCEHGEEASEAKCRCSLVHKPGEVVVSYGGMRVRPKCYGFSRMMATLEVNPPEQRIGQCTGCHLECINGGVRLITLTSELRSATVCASHFCSSASSGKKSTEIHFHSGSLVGKTAIHVKGALVDGTEFTFEGSCMFPDGCDAVDCTFCREFLKNPQCYPAKKWLFIIIVILLGYAGLMLLTNVLKAIGVWGSWVIAPVKLMFAIIKKLMRTVSCLVGKLMDRGRQVIHEEIGENGEGNQDDVRIEMARPRRVRHWMYSPVILTILAIGLAEGCDEMVHADSKLVSCRQGSGNMKECITTGRALLPAVNPGQEACLHFTAPGSPDSKCLKIKVKRINLKCKKSSSYFVPDARSRCTSVRRCRWAGDCQSGCPPHFTSNSFSDDWAGKMDRAGLGFSGCSDGCGGAACGCFNAAPSCIFWRKWVENPHGIIWKVSPCAAWVPSAVIELTMPSGEVRTFHPMSGIPTQVFKGVSVTYLGSDMEVSGLTDLCEIEELKSKKLALAPCNQAGMGVVGKVGEIQCSSEESARTIKKDGCIWNADLVGIELRVDDAVCYSKITSVEAVANYSAIPTTIGGLRFERSHDSQGKISGSPLDITAIRGSFSVNYRGLRLSLSEITATCTGEVTNVSGCYSCMTGAKVSIKLHSSKNSTAHVRCKGDETAFSVLEGVHSYIVSLSFDHAVVDEQCQLNCGGHESQVTLKGNLIFLDVPKFVDGSYMQTYHSTVPTGANIPSPTDWLNALFGNGLSRWILGVIGVLLGGLALFFLIMFLLKLGTKQVFRSRTKLA
What is the function of this protein?
Structural component of the virion that interacts with glycoprotein N (By similarity).  Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (By similarity).  The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity).  They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (By similarity).
What are the official names of this protein?
Envelopment polyprotein, M polyprotein.
What is the protein family that this protein belongs to?
Belongs to the phlebovirus envelope glycoprotein family.
What are the subcellular locations of this protein?
[Glycoprotein N]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein C to the Golgi complex, where virion budding occurs. SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Interaction between Glycoprotein N and Glycoprotein C is essential for proper targeting of Glycoprotein C to the Golgi complex, where virion budding occurs.
Protein: RR2_PHAAO
Sequence: MGRRYWNINLEEMMEAGIHFGHVTNKWNPRMAPYISSKRKGIHITNLTITARFLSEACDLVFDAASRGKRFLIVGTKKKAADLVASAAIKARCHYVNKKWLGGMLTNWSTTETRLQKFRDLRAEQKMGKLNRLPKGDAAMLKRKLSTLQAYLGGIKYMTGLPDIVIIVDQQEEYTVLRECVILGIPTICLIDTNCDPDLADISIPANDDAIASIRLILTKLVSAICEGHSSYIKKG
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NADA_BURO0
Sequence: MQSTIKPVEYDRPVAAGTVCGVGQAWAKVPDAPSAEERAALKARIKALLAREKAVLVAHYYVDAELQELADETGGCVADSLEMARFGRDHDAQTLVVAGVRFMGETAKILSPNKRILMPDLDATCSLDLGCPVGEFSAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLEIVADLHARGEKIIWAPDRHLGSYIQKKTGADMLLWQGSCLVHDEFKGIELDLLRAEYPDAKVLVHPESPENVVAQADVVGSTTQLIDAAVKFDAKRFIVATDLGILHKMQLAAPGKTFIAAPTAGNSATCKSCAHCPWMAMNGLANLADVLERGHNEIFVDPAIGERARLPIDRMLEFAAAHKKRVQASGDLQRDQSLFANVGAA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
Protein: ATP6_STRPB
Sequence: MEEAKIPMLKLGPITFNLTLLAVCIVTIAVIFAFVFWASRQMKLKPEGKQTALEYLISFVDGIGEEHLDHNLQKSYSLLLFTIFLFVAVANNLGLFTKLETVNGYNLWTSPTANLAFDLALSLFITLMVHIEGVRRRGLVAHLKRLATPWPMTPMNLLEEFTNFLSLAIRLFGNIFAGEVVTGLIVQLANYRVYWWPIAFLVNMAWTAFSVFISCIQAFVFTKLTATYLGKKVNESEE
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ILVD_ECO57
Sequence: MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDSQSDQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHSDRKQLFLNAGKRIVELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVKNVLGLTLPQTLEQYDVMLTQDDAVKNMFRAGPAGIRTTQAFSQDCRWDTLDDDRANGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGSIGLIEDGDLIAIDIPNRGIQLQVSDAELAARREAQEARGDKAWTPKNRERQISFALRAYASLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: DISA_CLOBM
Sequence: MRIEKDKELMNILKIMAPGTPLREGLENILRAKTGGLLILGDSDQILKLVDGGFKINSEYSPSYVYELAKMDGSIVLSSDLKKILCANAQLIPDSSIPTFETGTRHRTADRVAKQTGSIVIAISQRRNIITVYKGGIKYVLRDSSIILARANQALQTLEKYVAVLDRVVNNLNILEFKDIATLFDVVTAIQRSEMVMRIVSEIERYICELGNEGRLIDMQLSELIKSVEEDGILLIRDYCRSNMEYEDIYKQIQGLSSEELLNLDGLSKIIGYTGVPLVDTLISPRGYRMINKIPRIPSNVIENLVANFNQLKCVMEASYEQLDNVEGIGEARAKAIKNGLRRLREQIMLDKV
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: Y396_STAAN
Sequence: MRYLKRLSWYISILILIVVIAGCGKGNETKEGSKEEQIKKSFAKTLDMYPIKNLEDLYDKEGYRDSEFKKSDKGTWTIYTDFAKSNKPGELDDEGMVLNLDRNTRTAKGHYFVTTFYRNGKLPDEKNYKIEMKNNKIILLDEVKDDKLKQKIENFKFFGQYANLKELRKYNNGDVSINENVPSYDVEYKMSNKDEIVKELRSRYNISTEKSPILKMHIDGDLKGSSVGYRKLEIDFSKRENSKLSVIEFLSYKPAKK
What are the official names of this protein?
Uncharacterized lipoprotein SA0396.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ACPS_SYMTH
Sequence: MILGTGVDIVAVERVARAVERHGDRFLRRVFTPGELAYCTSSEAHRAARLAARFAAKEAVLKALGIGLREVRWTDAEVCRDERGRPSVRLTGRLAEIAAARGATRIHLSLSHTQEYAVAQVVIEG
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIM1_YEASZ
Sequence: MSDEIVTNKSVTYVNNTTPVTITSSELDLRSCYQDDEVVIEVHAAALNPIDFITHQLCNSYIFGKYPKTYSRDYSGVIIKAGKDVDNRWKVGDKVNGMYSHIYGERGTLTHYLILNPAKDIPITHMVEVPKDENDPYDDFVYAAAWPLTFGTAFSTLYDFKKDWTSDSKVLVIGASTSVSYAFVHIAKNYFNIGTVVGICSKNSIERNKKLGYDYLVPYDEGSIVENVKKLKQIVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNNKANYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYPPNNFIEVGNEMIKKGTYKPPIDSVYEFDQYKEAIDRLMSNRAKGKVVVKMK
What are the official names of this protein?
Protein YIM1.
What is the protein family that this protein belongs to?
Belongs to the YIM1 family.
What are the subcellular locations of this protein?
Lipid droplet. Mitochondrion.
Protein: RL30_SULIY
Sequence: MVELLGIIRIRGWAKAPWYINETLEMLRLRYNFNTMMYPKTSQILGMLNKVSPYVTWGEIDPDTLKLLIIKRLETAKGDKVSDSYVKEVLKIENIDTMVKQLYEGKIYLHKLDQYFKLPIRLHPPKGGFKGSVKRPYKNKGEFGYRGNKINELMRRMM
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: RLMM_ACTPJ
Sequence: MNKLALYCRAGFEKETAGEITDKAAQLGVFGFVNLKENSGYIIFECYQAGDADRLARELKFEQLIFARQMIVVGDMLQDLPVEDRISPIVAQYQALNPRHSSDIFVETPDTNEAKELLTFCRKFTVPLRNSLKKQGWLTKSERAKGSIGLHILFVRPGCCYVGYAYNDNKSPFFMGIPRLKFPAEAPSRSTLKLEEAILTFIPEAEEKKRFTDEMTGVDLGACPGGWTYQLVKRGVFVYAVDHGKMAASLHETGRIEHCPEDGFKFQPPKRKTIDWLVCDMVEQPMRISKLIGKWLINGWCRETIFNLKLPMKKRYQEVQLCLAYLEEELEKQGFWFKIQAKHLYHDREEITVHIAVMGKR
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_LISMF
Sequence: MNKLIDEITKSQLNPDVPNFRPGDTVRVHAKVVEGTRERIQLFEGVVIKRRGAGISETFTVRKISNSVGVERTFPVHTPRIAKLEVIRRGKVRRAKLYYLRNLRGKAARIKEIR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: YLC1_CAEEL
Sequence: MKSILLLFSLIVLGSATEEVSRTEQTSTLFSVEGEIALPSTRNCAKWSAGARIHLNHGQYMGFVRQDCTFRVDFVPTGTYIVQIENTDFVFEPIRVDITSKGKMRARKLTILQPNNVNTLPYPLRLSARGPARYFRKREEWRITDMLFSPMVLMLVVPLVVMLILPKMTANDPELKKEMENMQMPKVDMPDVGEMMANFFGGSAPAKKKAVTGGSGSGQRRK
What are the official names of this protein?
ER membrane protein complex subunit 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the EMC7 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RR19_PHATC
Sequence: MPRSLKKSPFVAYHLLKKINQMNKAGKKDTITTWSRSSTILPSMIGFTIAVYNGKQHVPIFISDQLVGHKLGEFVSTRNFRTHIKADRKTKR
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NRAM_INBMD
Sequence: MLPSTIQTLTLFLTSGGVLLSLYVSASLSYLLYSDILLKFSPTKRTAPTMSLECVNVSNAQAVNHSATKEMTFLLPEPEWTYPRLSCQGSTFQKALLISPHRFGETRGNSAPLIIREPFVACGPKECRHFALTHYAAQPGGYYNGTRKDRNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGREWTYIGVDGPDSDALIKIKYGEAYTDTYHSYAHNILRTQESACNCIGGDCYLMITDGSASGISKCRFLKIREGRIIKEIFPAGRVEHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVETDTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGLGGIKGGFVHQRMASKIGRWYSRTMSKTERMGMELYVKYDGDPWTDSDALAPSGVMVSIKEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: LSPA_FRATN
Sequence: MNLLRPKLKYFILAILIIAADLYTKYLANTYLEFAQSVKITSFFNLTLLYNHGAAFSLLSNDQTSWQMIMFSTISLIAAIVLIYLIIKQPITEKINLFSFALILGGALGNFYDRAFQGYVIDFLDFHIGNYHWPSFNIADSAITCGVVILIAASLFTKKKS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CELB_LACLA
Sequence: MNGITAWMEKYLVPVAAKIGSQKHLVALRDSFIGMLPATLAGALAAMISAIVTTFPSAIQQMMLGATAFSKLAPEKVWTLANTPIIGDLNNISALVNQGTLTVIGLIFAFSWGYNLARAYGVNDLAGGIVSLATLFAGLPNQMGKFTAALGTGKAGVAATDKLNGVLGDQGLAAWKPLFASAHLDAGAYFTVIIMGALAVIIYAKLMLADITIKMPESVPPAVAKAFLAIIPTIAALYIVGLIYYIIGKLTNDSVINLITHYIAEPFQILSQNIFSVLIVTLFVSVFWFFGLHGPNVLAPVLDGIWGPLGLNNQALYFQVHSQGIRDLIAKGAVDKAHAINGDYVNLWVRGSWDAFAWFGGSGGTITLVIAIILFSKRKDYKIVGRLGLAPGIFNINEPVLFGLPVVLNAIFFIPFAVAPLISVIIAYTATALHLVDPVVNAVPWVTPPIMNAFMATGFDWRAIVLTIINLIITFVIWVPFVIAANKLEETELD
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane (By similarity).  Involved in cellobiose transport with PtcA and PtcB.  This system can also transport lactose (PubMed:17909747, PubMed:21262549).
What are the official names of this protein?
PTS system cellobiose-specific EIIC component.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YQGF_LACDA
Sequence: MRLLGLDVGSKTIGVAVSDPLGITAQSVMTIPIDEDRHNFGMRSLKKLVREYEANGFVLGLPKNMDGTAGRSVSRSKAMGERLEQKFGLPVYYDDERLTTVASERILVEEAGMHDRRQRKEVVDQMAAVLILQNYLDLQRKE
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEK3_ARATH
Sequence: MEHYEVLEQIGKGSFGSALLVRHKHEKKLYVLKKIRLARQTGRTRRSAHQEMELISKIRNPFIVEYKDSWVEKGCYVCIVIGYCKGGDMAEAIKKANGVEFSEEKLCKWLVQLLMALEYLHASHILHRDVKCSNIFLTKDQDIRLGDFGLAKILTSDDLASSVVGTPSYMCPELLADIPYGSKSDIWSLGCCMYEMTALKPAFKAFDMQGLINRINRSIVAPLPAQYSTAFRSLVKSMLRKNPELRPSASDLLRQPLLQPYVQKVLLKLSFREHDTLPSESERRSSYPQQRKRTSGKSVSFGPSRFGVDQEDSVSSVKPVHTYLHRHRPVDLSANDTSRVVVRRPAVSSVVSNSSKYVPVRSNQPKSGGLLKPAVVTRRASLPISQKPAKGTKDSLYHPNIGILHQLNSPDVSVNSPRIDRIKFPLASYEEMPFIPVVRKKKGSSRGSYSPPPEPPLDCSITKDKFTLEPERETKSDLSDQNATAGASSRASSGASRRQRFDPSSYRQRAEALEGLLEFSARLLIDERYDELNVLLKPFGPGKVSPRETAIWLSKSFKESSPSNLEED
What is the function of this protein?
May be involved in plant development processes.
What are the official names of this protein?
Serine/threonine-protein kinase Nek3, NimA-related protein kinase 3, AtNek3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Protein: CSRA_PSEA6
Sequence: MLILTRRVGETLMVGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYMRIQAEKNGQLAGHDSSSSDEDN
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSDHB_RUMGV
Sequence: MTLREKYGEWGIILGATEGVGKAFCERLAKEGMNVVMVGRREEKLKELGEELKNTYEIDYKVVKADFSLPDATDKIFAATENLDMGFMAYVACLHSFGKIQDTPWEKHEAMINVNVVTFMKCFYHYMKIFAAQDRGAVINVSSMTGISSSPWNGQYGAGKAFILKMTEAVACETEKTNVDVEVITLGTTLTPSLLSNLPGGPQGEAVMKTAQTPEEVVDEAFEKLGKELSVISGERNKASVHDWKANHTEDDYIRYMGSFYQE
What is the function of this protein?
7beta-hydroxysteroid dehydrogenase that catalyzes the reduction of the 7-oxo group of 7-oxo-lithocholate (7-oxo-LCA), to yield ursodeoxycholate (UDCA).  As R. gnavus is a common core bacterium of the human gut microbiota, this enzyme contributes to the formation of UDCA in the human colon.  UDCA is regarded as a chemopreventive beneficial secondary bile acid due to its low hydrophobicity; it protects hepatocytes and bile duct epithelial cells against necrosis and apoptosis induced by more hydrophobic secondary bile acids like deoxycholate (DCA).  This enzyme is also able to catalyze the reverse reaction in vitro, i. e.  the oxidation of the 7beta-hydroxy group of UDCA to 7-oxo-LCA, but much less efficiently than the reduction reaction.
What are the official names of this protein?
7beta-hydroxysteroid dehydrogenase, 7beta-HSDH, NADP-dependent 7beta-hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.