PharMolix/UniProtQA huggingface dataset:
Protein: RK19_GUITH
Sequence: MKSNKNLIQLVESNHSNKTLPQLQVGDTVRLGVSITEGNKERIQATEGVIISKSNCGINLTITIRRVLQGIGIERVYLLHSPKLKSIEILRKSKIRRAKLYYLRTRSGKATRLQQRFN
What are the official names of this protein?
50S ribosomal protein L19, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: YWKB_BACSU
Sequence: MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKYALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFSLNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNEESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGVALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAFPGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA
What are the official names of this protein?
Uncharacterized transporter YwkB.
What is the protein family that this protein belongs to?
Belongs to the auxin efflux carrier (TC 2.A.69) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABH_PROM2
Sequence: MEEIKFNQIGVSFKGSGSYVPDQILTNEEISQKVDTSDEWIKSRTGISERRISRVEDNVADMGYKAALTAIEMANWDIKTIDLIVLATSTPHDLFGSAPSIQSKLGASNAVAFDLTAACSGFLFALITTSQFLKAGNFKRALVVGADQLSSFVDWNDRRSCILFGDGAGALAIEATNEFDNFIGFDMRTDGERGCFLNLPSKNNEDSIIDNIEFLSGGFSPIQMNGQEVYKFAVKEVPIILDKLFKKTNYSSDEVDWLILHQANQRILDSVGDRLKIPREKILSNLEKYGNTSAATIPLMIDEAIRNHSIKQNDIIATSGFGAGLSWGAALIKWG
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNPA_HAEDU
Sequence: MNKLTFSRELRLLAPIQFKAVFEQPYRASTAELTILARQNCVNTPRLGLTVAKKHLKRAHDRNRIKRIVRESFRLKQHQLPNFDFVFVAKHGIGKLDNATLFATIDKLWTRHIRLSQQAQSKN
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: MTNA_GEOTN
Sequence: MSTFAIPRSVEWHETHVTILNQQKLPSVTEYLDLHTLEDVHDAIVTLKVRGAPAIGITAAYGLALAASRYETESVDEFQRRLKQDRDYLASARPTAVNLFWALDRLVAAAKSAASVNEAKTTLVHEAIRIQIEDEDVCRRIGEHALSLFHRGDRIMTICNAGSIATARYGTALAPFYLAKEKGIELSVYALETRPVLQGARLTAWELMQAGVDVTLITDNMAAQTIKAKNINAIIVGADRIAQNGDTANKIGTFGLALLAQSFGIPFYVAAPLSTIDLATKTGADIPIEERHPDEVTHLNGVRIAPEGVNVYNPAFDVTPNELITAIITEKGIVYGDYETELPSLVAKEEHHETA
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: CINA_CLOK1
Sequence: MKSEILCVGTEILLGDIVNTNSQFISKELANLGIEVYHQSVVGDNPQRLLDELKLGFERSDIIITTGGLGPTQDDLTKETGAKFFNRELVLDKKSLKELKEHFNRMGKSYSDGNNIKQAYFPKGSTIFPNPYGTAPGCAIEDKGKILIVLPGPPRETKPMFKNYVIPLLKKYSNGIIKSKTLRIYGLGESAMAERVSPFIENSTNPTVAPYAKEEDIILRITARAAEEKEALSLIEPVEIELRKILGVNVYGEDDVKMEEVLGRLLIDKGYTLSCAESCTGGLIASKLINYPGISKAFKEGVVAYSNEAKIKRLGVKKDTLDKYGAVSPEVAKEMAIGIAETSNTDIGISTTGIAGPDGGTPEKPIGLVYLGLYNRGEIKVKELRHAGTRDMIRKRATMNALDWIRRQIL
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: COPA_SCHPO
Sequence: MEMLTKFESRSSRAKGVAFHPTQPWILTSLHNGRIQLWDYRMGTLLDRFDGHDGPVRGIAFHPTQPLFVSGGDDYKVNVWNYKSRKLLFSLCGHMDYVRVCTFHHEYPWILSCSDDQTIRIWNWQSRNCIAILTGHSHYVMCAAFHPSEDLIVSASLDQTVRVWDISGLRMKNAAPVSMSLEDQLAQAHNSISNDLFGSTDAIVKFVLEGHDRGVNWCAFHPTLPLILSAGDDRLVKLWRMTASKAWEVDTCRGHFNNVSCCLFHPHQELILSASEDKTIRVWDLNRRTAVQTFRRDNDRFWFITVHPKLNLFAAAHDSGVMVFKLERERPAHALNINTLLYVNKEKSIVSYDLLRAQSTTVASVKHLGSAWLPPRSLSYNPAEKVALLTSSADNGVYELVNVSSRSNSLPLKDNIKGPGDDAIFVARNRFAVFSRSDQTIEIKDLSNKVTKTIQLPEKTRDIFFAGMGHVLLSTATQVHLFDLQQKKIVSSFNANRVKYVVWSNDNSQAALLGKHYVYIVKKNLELITSIHETIRIKSAVWVENNVLLYATLDHLKYALMSGDTGVIKTLESTLYLVKAKGNMVFALNRAAEPVSFEIDPTEYLFKLALLRKDYEQVLHLIQNSNLVGQAIIAYLQKKGYPEIALQFVEDPSTRFELALECGNLETALELARTIDRPEVWSRLASDAMSYGNHKIAEITFQKLRYFEKLSFLYLITGNAEKLQKMAIIAEKRNDTLSLFQNSLYLNEVESRINILEQAGMYPIAYLTAKSNGLEEKAQQILSHCNKTEEEIKLPSLGSAFTTPVPVNETYTHNWPLLDTSHSTFEKSLQERMEQLAIERQEEQESEEEYEEVEQSLMDVVDEMSDLAESVPEEEVDGWEVEDLAPEEAVNDVVDDASAFVGADEIFLWKRNSPLAADHIAAGDFESAMKILNKQVGAINFSPLKTRFLEIYTASRVYLPTISGLDPLVSYVRRNAETAERSQALPFITRNLASIKSHELHEAYRLVKANKILEAQICFRSIIYLALTTVANSEEEADEISALIDECCRYIVALSCELERRRLGEEDTKRALELSYYFASADLQPMHSIIALRLAINASHKLKNYKSASFLGNKLLQLAESGPAAEAANRAITLGDRNPHDAFEIEYDPHVEMRICPKTLTPVYSGDDFDVCSVCGAVYHKGYVNEVCTVCDVGGIGQKGTGRRFFA
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Putative coatomer subunit alpha, Alpha-coat protein, Alpha-COP.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RL18_XANCB
Sequence: MSINKNIARLRRAKSTRAHIRELGVARLSVLRTGQHLYAQVFTADGSKVIAAANTLQADVKDGLKNGKNSDAAVKVGKLIAERAKAAGIEKVAFDRSGYRYHGRIKALADAAREGGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ISCS_HELPJ
Sequence: MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIITTVAEHPAVRSTCNFLESLGVEVTYLPINEHGSITADQVKEAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSGTLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRVHRVPNTTLISVRGIEGEAMLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAAVRLRNISSSY
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOR2_TTV1K
Sequence: MTRYNYIRNLRIIRGEEIKVGVSSDRIPMIEIEPGHNDPERMCVMFTAMEYSHIPYQADNLDEVYDSCKILTSKITTYINVAIGFGKNLGLKLSEMMLVTRDKSKREFKVGLELGIKYAYNWTCKFQ
What are the official names of this protein?
Uncharacterized 14.8 kDa protein.
Protein: RL19_DICTD
Sequence: MDLIIQNLEKEYMKKDIPEIWPGDTVRVHYRIVEGDKERIQVYEGVVIAKKHGGIRETITVRKVVQGVGVERIFPLHSPLVEKIEVVRRGRVRRAKLYYLRERKGKSAKIAEREENEG
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PYRB_LACLE
Sequence: MTTVSQNQVVVETEDKQDNLLRLPYFVSVEQLSADDVLHLLQRAQYFKNGGEVPALSRPIFCTNMFFENSTRTHTSFEVAERRLGLTVIPFDPSHSSVNKGENLYDTELTMASLGIELSVIRHPENAYYNEIIRPKEGQHLQMGLVNAGDGSGQHPSQSMLDMMTIYNEFGHFDGLKIMIVGDLTNSRVARSNMEILNTLGAEVYFSGPEYWYNAEEFSKYGTYVKNIDDEIPELDVLMLLRVQHERHNGAEAKTEQLFDAKDYNAAYGLNQRRYDMLKDDAIIMHPGPINRGVEWDGDLVEAPKSRYAVQMHNGVFVRMAMIEAVLRGRKLGGLE
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RL29_METTP
Sequence: MAIFRIDEIRNMSSEELEEELRKLEVELIRERGAVRAGGAPEKPGRIREIRRTIARMKTVQRERVRK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: T120B_MOUSE
Sequence: MSGQLERCEREWHELEGEFQELQETHRIYKQKLEELTSLQTLCSTSISKQKRHLKDLKHTLQRYKRHSSHEEAALIQQMTANIKERQNVFFDMEAYLPKKNGLYLNLVLGNVSVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGLIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSTHEECKEWQVFVLALTFLILFLGNFLTTLKVVHAKLHKNRNKTKQP
What is the function of this protein?
Necessary for efficient adipogenesis (PubMed:26024229).  Does not show ion channel activity (PubMed:32084332).
What are the official names of this protein?
Transmembrane protein 120B.
What is the protein family that this protein belongs to?
Belongs to the TMEM120 family.
Protein: CRL_ENT38
Sequence: MTLPSGHPKSRLIKKFMALGPYIREEQCEENRFFFDCLAVCVNVQPAPEEREFWGWWMEMEAEEKRFTYTYHFGLFNKAGHWQATTIKDKEVVERLEQTLRGFHEKARALLETFELKLEPADDFTNEKLKLSA
What is the function of this protein?
Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes.  Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32.
What are the official names of this protein?
Sigma factor-binding protein Crl.
What is the protein family that this protein belongs to?
Belongs to the Crl family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNS1_PANGI
Sequence: GVQKTEVEATSTVPAQKLYAGLLLDIDDILPKAFPQAIKSSEIIEGDGGVGTVKLVTLGEASQFNTMKQRIDAIDKDALTYTYSIIGGDILLDIIESIVNHFTIVPTPDGGSIVKNTTIYNTIGDAVIPEENIKDATEKAGLIFKAVEAYLLAN
What is the function of this protein?
Catalyzes the two-stage endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.
What are the official names of this protein?
Ribonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_BRUSI
Sequence: MNSIPEGRPTPNLPRTANKRGVARLAAAQALYQMDVAGTGVMEVVAEYEAFRLGKEVDGTQYLDADPQWFRAIVAGVVEDQLKLDPMIHQALTEDWPLSRLDSTLRAILRAGAWELKARKDVPTAVIVSEYVDIAKAFYTEDEPKLVNAVLDRLALVIRGESRGAKPRHKS
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: FLGI_HELPY
Sequence: MKRVFLWLIFVLAFHKLLAEKIGDIASVVGVRDNQLIGYGLVIGLNGTGDKSGSKFTMQSISNMLESVNVKISADDIKSKNVAAVMITASLPPFARQGDKIDIHISSIGDAKSIQGGTLVMTPLNAVDGNIYALAQGAIVSGNSNNLLSANIINGATIEREVSYDLFHKNAMTLSLKNPNFKNAIQVQNTLNKVFGNKVAIALDPKTIQITRPERFSMVEFLALVQEIPINYSAKNKIIVDEKSGTIVSGVDIMVHPVVVTSQDITLKITKDPLNDSKNTQDLDNNMSLDTAHNTLSSNGKNITIAGVVKALQKIGVSAKGMVSILQALKKSGAISAEMEIL
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: ESMB_DROME
Sequence: MVLEMEMSKTYQYRKVMKPMLERKRRARINKCLDELKDIMVECLTQEGEHITRLEKADILELTVEHMKKLRAQKQLRLSSVTGGVSPSADPKLSIAESFRAGYVHAANEVSKTLAAVPGVSVDLGTQLMSHLGHRLNYLQVVVPSLPIGVPLQAPVEDQAMVTPPPSECDSLESGACSPAPSEASSTSGPMWRPW
What is the function of this protein?
Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity).  May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes (PubMed:1528887).  Contributes to the neural-epidermal lineage decision during early neurogenesis (PubMed:1427040).  Part of the Notch signaling pathway (PubMed:1427040).
What are the official names of this protein?
Enhancer of split mbeta protein, E(spl)mbeta, HLH-mbeta, Split locus enhancer protein mA.
What are the subcellular locations of this protein?
Nucleus.
Protein: UREE_BURPS
Sequence: MRTIDKRIAPNVRLAATLVARAPALTLAYDARCKSRLAATLDTGEDVALVLPRGTVLRDGDVLVADDGALVRVAAAHEAVLLVRAPDALTLTRAAYHLGNRHTPVEVGAGCLKLEYDPVLADMLTRLGATVERASAPFQPEAGAYGGGHRHGHDATFAEDYALAQQVFDEHHGHSHSHDHDHDHDHDHDHQHGPCCSHGHHHGHR
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PI4KB_BOVIN
Sequence: MGDTIVEPAPLKPTSEPAPGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGATVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLGCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
What is the function of this protein?
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) (PubMed:9218477, PubMed:11526106).  May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity).  Involved in Golgi-to-plasma membrane trafficking (By similarity).
What are the official names of this protein?
Phosphatidylinositol 4-kinase beta, PI4K-beta, PI4Kbeta, PtdIns 4-kinase beta.
What is the protein family that this protein belongs to?
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
What are the subcellular locations of this protein?
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Golgi apparatus membrane. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3, GGA2 is also involved in the recruitment.
Protein: RS5_STAEQ
Sequence: MARREEETKEFEERVVTINRVAKVVKGGRRFRFTALVVVGDKNGRVGFGTGKAQEVPEAIKKAVEAAKKDLVVVPRVEGTTPHTITGQYGSGSVFMKPAAPGTGVIAGGPVRAVLELAGITDILSKSLGSNTPINMVRATINGLQNLKNAEDVAKLRGKSVEELYN
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: MIG1_KLULA
Sequence: MTEAIIEKKNHKKSINDHDKDGPRPYVCPICQRGFHRLEHQTRHIRTHTGERPHACDFPGCSKRFSRSDELTRHRRIHDSDKPKGKRGRKKKSETIAREKELELQRQKQRNANDSAAVDSAGGTSANVIEPNHKLLKSTNSIKQDGSTFTEPLKSLRSKPMFDLGSDESDECGIYSVPPIRSQNNSGNIDLLLNAAKFESDKASSSFKFIDKLPLTSSSSSPSLSFTSHSINNSSSGLLLPRPASRAKLSALSSLQRMTPLSQNSESYNHSQQNLVHLHHPAPNRPLTEFVDNEYISNGLPRTRSWTNLSEQQSPSGFSSSALNSRFSSSNSLNQLIDQHSRNSSTVSISTLLKQETVISQDEDMSTEDAYGRPLKKSKAIMPIMRPSSTMPPSSGSATEGEFYDELHSRLRSMDQLPVRNSKDEKDYYFQSHFSSLLCTPTHSPPPEGLLPSLNQNKPVQLPSLRSLDLLPPK
What is the function of this protein?
Involved in glucose repression of glucose metabolism genes.
What are the official names of this protein?
Regulatory protein MIG1.
What is the protein family that this protein belongs to?
Belongs to the creA/MIG C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GTHB2_ONCTS
Sequence: MLGLHVGTLISLFLCILLEPIEGSLMQPCQPINQTVSLEKEGCPTCLVIRAPICSGHCVTKEPVFKSPFSTVYQHVCTYRDVRYEMIRLPDCPPWSDPHVTYPVALSCDCSLCNMDTSDCTIESLQPDFCITQRVLTDGDMW
What is the function of this protein?
Involved in gametogenesis and steroidogenesis.
What are the official names of this protein?
Gonadotropin subunit beta-2, GTH-II-beta, Gonadotropin beta-II chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: IN35_MOUSE
Sequence: MSVTLQTVLYSLQEEQARLKMRLQELQQLKRERTGSPGAKIPFSVPEVPLVFQGQTKQGRQVPKFVVSNLKVCCPLPEGSALVTFEDPKVVDRLLQQKEHRVNLEDCRLRVQVQPLELPVVTNIQVSSQPDNHRVLVSGFPAGLRLSEEELLDKLEIFFGKAKNGGGDVETREMLQGTVMLGFADEEVAQHLCQIGQFRVPLDRQQVLLRVSPYVSGEIQKAEIKFQQAPHSVLVTNIPDVMDAQELHDILEIHFQKPTRGGGEVEALTVVPSGQQGLAIFTSESS
What is the function of this protein?
Acts as a signaling pathway regulator involved in innate immune system response (PubMed:29350881).  In response to interferon IFN-alpha, associates in a complex with transcriptional regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (By similarity).  In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (By similarity).  In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881).  Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (By similarity).  Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (By similarity).
What are the official names of this protein?
Interferon-induced 35 kDa protein homolog, IFP 35, Ifi-35.
What is the protein family that this protein belongs to?
Belongs to the NMI family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Secreted. Note=Cytoplasmic IFI35 localizes in punctate granular structures (By similarity). Nuclear localization increased following IFN-alpha treatment (By similarity). Extracelullar following secretion by macrophage (By similarity).
Protein: PROA_SALSV
Sequence: MLEQMGIAAKAASYKLALLSSCEKNRVLEKIADELEAQMESILSANVQDVEQARANGLSEAMLDRLALTPARLKAIADDVRQVCNLADPVGQVIDGGLLDSGLRLERRRVPLGVVGVIYEARPNVTVDVASLCLKTGNAVILRGGKETHRTNAATVRVIQKALKACGLPEAAVQAIDNPDRSLVNEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDSSADIAPALKIIVNAKTQRPSTCNTVETLLVHQDIAERFLPVLSKQMAESGVTLHGDETVMQALHGPAKLVPLKPEELDNEFLSLDLNVVVVENMDGAIAHIREHGTQHSDAILTSDMHNAARFVNEVDSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGFGDGTIRA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLRB_HUMAN
Sequence: MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
What is the function of this protein?
Glycine receptors are ligand-gated chloride channels.  GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels.  Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346).  Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357).  Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346).  Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
What are the official names of this protein?
Glycine receptor subunit beta, Glycine receptor 58 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane.