PharMolix/UniProtQA huggingface dataset:
Protein: PETL_MAGST
Sequence: MLTITSYFGFLLAALTITSALLIGLSKIRLI
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 6, Cytochrome b6-f complex subunit PetL, Cytochrome b6-f complex subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PetL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RLMH_PELPD
Sequence: MRLRVLWVGKSREEWVKQALADYATRIRRYAPLELVEVRDEKGAMAEEMRRRECERLEKQIPPGATLLLLDERGEQMDSPGLAAYIGKQRDSGTADLVLVIGGAYGFSDAFRRRGRLLSLSPMTFTHQMVRVFLLEQLYRSFTILNNEPYHH
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JSPR1_HUMAN
Sequence: MSMTTRAWEELDGGLGSCQALEDHSALAETQEDRASATPRLADSGSVPHDSQVAEGPSVDTRPKKMEKEPAARGTPGTGKERLKAGASPRSVPARKKAQTAPPLQPPPPPPALSEELPWGDLSLNKCLVLASLVALLGSAFQLCRDAVPGEAALQARVPEPWVPPSSAPREPSSPLPKFEAQAPPSAPPAPRAEAEVRPKIPGSREAAENDEEEPGEATGEAVREDRVTLADRGPKERPRREGKPRKEKPRKEERPKKERPRKEERPRAAREPREALPQRWESREGGHRPWARDSRDAEPRKKQAWVSPRRPDEEQRPGSRQKLRAGKGRD
What is the function of this protein?
Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S.  EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels.  May regulate CACNA1S membrane targeting and activity.
What are the official names of this protein?
Junctional sarcoplasmic reticulum protein 1, Junctional-face membrane protein of 45 kDa homolog, JP-45.
What are the subcellular locations of this protein?
Sarcoplasmic reticulum membrane. Endoplasmic reticulum membrane. Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes.
Protein: RIMK_LEGPA
Sequence: MKIAILATNPHLYSHKRLKAEAEAAGHEVKIINPLYCYMNVAASNPKVHYRGGAPLPHFDAVIPRIGASITYYGTAVLRHMETMGMYTLNESIAISRSRDKFRSLQLLARKGIPMPLTSFAQSPDDTEDLIHMVGGAPLVIKLLEGTQGKGVILADSHQSAVSIINAFKEMHANILVQEFIEESRGTDIRCFVIGEKVVAAVKRQAKDGEFRANVHQGGKAVKVKLSPQERAIAVSAAKTMGLRVAGVDLIRSNHGPLVLEINSSPGLEGIEKATNINLAGKIIEYIEKKAKPISSNHRFHG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: SUCC_RHIE6
Sequence: MNIHEYQAKALLKGYGAPVAEGVAILKAEEAEAAAKSLPGPLYVVKSQIHAGGRGKGKFKELSPEAKGGVRLAKSVEDVVANVKEMLGNTLVTAQTGEAGKQVNRLYIEDGADIERELYCSLLVDRSVGKVAFVVSTEGGMDIEAVAHDTPEKIQTIAIDPETGVTAADVAKISSALKLDGAAGEDAKSLFPLLYKAFNEKDMSLLEINPLIVMKNGHLRVLDAKMSFDGNALFRHDDVRALRDETEEDAKEIEASKWDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGKEPANFCDVGGGAGKEKVAAAFKIITADPKVEGILVNIFGGIMKCDVIAEGVIAAVKEVGLKVPLVVRLEGTNVELGKKILNESGLAITAADDLDDAAKKIVAAING
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: SYK_SYNS3
Sequence: MSELRETRLEKANALKEQGQEPYALRFDLTDRMARLQADHADLAKGAERDLKVSVAGRVMTRRVMGKLAFFTLADETGTIQLFLEKATLGDSFAQLSSLVDAGDLIGVHGILRRTDRGELSVKVSKWEMLTKSLQPLPDKWHGLADVEKRYRQRYLDLIVTPQSRETFRRRAMAVSAIRRWLDERDFLEIETPVLQSEAGGAEARPFITHHNTLDLPLYLRIATELHLKRLVVGGFERVYELGRIFRNEGVSTRHNPEFTSVEVYQAYADYNDMMTLTEQLIASVCEQVCGTTRISYQGVEVDLTPSWRRATMHELVQEATGLDFTSFETREAAVEAMRAANLPAPDKADTVGRLLNEAFEHAVEPNLIQPTFVLDYPQEISPLARKHRSKPGLVERFELFIVGRETANAFSELTDPLDQRGRMELQQERRAAGDVEASGVDEDFIQALEVGMPPTGGLGIGIDRLVMLLTDSPSIRDVIAFPLMRPEG
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFTN2_MOUSE
Sequence: MGCGLRKLEDPDESSPGKIFSTLKRPQVETKTEFAYEYALLDFTLQASTNPDVIKINSVLDIVAKVEDYYLKGYVVGAIHPVIQPVGQRKHLPASHLYRAVLSRLKLSPKHSAAGGQRRARLVMEECPLTCEAQANDAAKELMDKINAAAKRGMKFVGLVSQCYLPSMHCNGASHDGVAESGLHVRQDSQDNCKGWNEGALGGHLSESGVEEEPQHESGQHQTERNSSPSYANPKRGEAPDGKLYMVFNAFEEDAASWAYQEGVLSMKVTRKGAVISALDANWLELTTFYYKQGFSLIDSFVCWETPKGDQLPKSLEGFFIYEEEGSGVPGSNRRGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPILRHDSEGNLATKQVVFLQRPVTWNSAAQTPERKGSRLLKGEDRNKVSSRSLGLDTNASQAAGGRAPLEEGSLSPSRECWTKEERPAQSDSFSGFSSSDSVLRELDDGQFDQEEGVTQVTCM
What is the function of this protein?
Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195).  May regulate B-cell antigen receptor-mediated signaling.
What are the official names of this protein?
Raftlin-2, Raft-linking protein 2.
What is the protein family that this protein belongs to?
Belongs to the raftlin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: GUAC_BACCZ
Sequence: MENVFDYEDIQLIPAKCIVNSRSECDTTVTLGKHKFKLPVVPANMQTIIDERIATYLAENNYFYIMHRFQPEKRISFIRDMQSRGLIASISVGVKEDEYEFVQQLAAEHLTPEYITIDIAHGHSNAVINMIQHIKKHLPESFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTNGDVAKSIRFGATMVMIGSLFAGHEESPGETIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMFVEHKGSLEDTLIEMEQDLQSSISYAGGTKLDSIRTVDYVVVKNSIFNGDKVY
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: RL21_BRUAB
Sequence: MFAVIKTGGKQYRVAANDLIKVEKVAGEAGDIVEFAEVLMVGSTIGAPTVAGSLVTAEVVEQGRGRKVIAFKKRRRQNSKRTRGHRQELTTIRISEILTDGAKPSKKAAEKKAPKADAAEGEAAKPKKAAPKKAATKAESAE
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: PUR9_NATTJ
Sequence: MTIQKINRVLLSVYDKTGLITLAQELKDMGVELVSTGGTLRHLQTHGIPVYSVEEVTGFPEILSGRVKTLHPKIHGGILAKNRENEELSSLDIKTFDLVIVNLYPFEQVMQKAEATEEEVMENIDIGGPTMIRAAAKNWYRVGVCVDPTDYEVLTQQLKQYHGLTDEFRKTLARKAFKHTAQYDKAIFNYFESVDTNKDDETELKFPEFNLLESRELPYGENPHQKASLLMESQKFIQHQGKGLSYNNFQDIDAAIKLVHEFQKPAVVAVKHTNPCGVGVSNTIEEAYDKAYQGDPVSIFGGIVACNRPVTEELASKLTEIFLDVIIAPEFEPRALEKLKSKSGTKVVEMDLEKMVGNKVEIKSTTFGYLCQEADYHHPHPQNWDRVAGEQAKPEEIDDLIIAEKIVKHVKSNAIVVVKEGQSLGIGAGQMNRVGASRIALENAGKESQNSVLASDAFFPFNDVVKLCSQYGVSAIVQPGGSKRDQDSIDLAQETGITMYFTGIRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: BIN2_HUMAN
Sequence: MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSENPQL
What is the function of this protein?
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton.  Modulates membrane curvature and mediates membrane tubulation.  Plays a role in podosome formation.  Inhibits phagocytosis.
What are the official names of this protein?
Bridging integrator 2, Breast cancer-associated protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin- rich ring-like structure.
Protein: ATPA_SINFN
Sequence: MDIRAAEISAILKDQIKNFGQEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLEADNVGVVIFGSDRDIKEGDTVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPINAKQRSRVDIKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAIILDTILNQKAIHDNGPEGDKLYCVYVAIGQKRSTVAQFVKVLEERGALQYSIIVAATASDPAPMQYLAPFAGCAMGEYFRDNGKHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDNGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETDLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQYREMAAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIFAGVNGYLDKLPVNQVGKFEQGLLSYLRSEGKAVLDTIRTEKAISDDTKAKLKTAIDSFSKSFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y119_ATV
Sequence: MGLAPSLATLAIALVFLGISLIFLVPAMVQGLYSIVSGVFSVASSVSNETGCPQSTEVVQLSNQTASISVPSQYAGIYTLYLSFISFVGSIFTDPIALIMLILVSLIITLFAFYYKNQG
What are the official names of this protein?
Putative transmembrane protein ORF119.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: SCL32_ARATH
Sequence: MTKTRILNPTRFPSPKPLRGCGDANFMEQLLLHCATAIDSNDAALTHQILWVLNNIAPPDGDSTQRLTSAFLRALLSRAVSKTPTLSSTISFLPQADELHRFSVVELAAFVDLTPWHRFGFIAANAAILTAVEGYSTVHIVDLSLTHCMQIPTLIDAMASRLNKPPPLLKLTVVSSSDHFPPFINISYEELGSKLVNFATTRNITMEFTIVPSTYSDGFSSLLQQLRIYPSSFNEALVVNCHMMLRYIPEEPLTSSSSSLRTVFLKQLRSLNPRIVTLIEEDVDLTSENLVNRLKSAFNYFWIPFDTTDTFMSEQRRWYEAEISWKIENVVAKEGAERVERTETKRRWIERMREAEFGGVRVKEDAVADVKAMLEEHAVGWGMKKEDDDESLVLTWKGHSVVFATVWVPI
What is the function of this protein?
Probable transcription factor involved in plant development.
What are the official names of this protein?
Scarecrow-like protein 32, AtSCL32, GRAS family protein 18, AtGRAS-18.
What is the protein family that this protein belongs to?
Belongs to the GRAS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LFNG_RAT
Sequence: MLQRCGRRLLLALVGALLACLLVLTADPPPTPVPAERGRRALRSLAGSSGAAPGPGSRAAVDPGVLVREVHSLSEYFSLLTRARRDADPPPGVASRQGDGHPRPPAEVLSPRDVFIAVKTTRKFHRARLDLLFETWISRHKEMTFIFTDGEDEALAKHTGNVVLTNCSAAHSRQALSCKMAVEYDRFIESGKKWFCHVDDDNYVNLRALLRLLASYPHTQDVYIGKPSLDRPIQATERISEHRVRPVHFWFATGGAGFCISRGLALKMGPWASGGHFMSTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTTELHEQVTLSYGMFENKRNAVHIKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIL
What is the function of this protein?
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules.  Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1.  Decreases the binding of JAG1 to NOTCH2 but not that of DLL1.  Essential mediator of somite segmentation and patterning.
What are the official names of this protein?
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: PUR7_NITSB
Sequence: MKKTELLYEGKAKKIWKTDDENILIAEFKDSLTAFDAQKKSEEAGKGALNCKISANLFKLLEEQGIKTHFVECISENEMVIKKAEMIMIEVVVRNIATGSLTKRLGIPDGTKLPFALVEFYYKNDALHDPLINDEHALILELVDHESELEELKRLGREINVVLKSFFDKANLNLVDFKVEFGKDSEGNIILADEISPDSCRFWDKTSGEKLDKDLFRHDLGNVKVAYEEVLKRITKVMQ
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: RS6_BIFLO
Sequence: MMSAHKYELMFIADPELDERGLKKLTEQYLELVTKEGGSFDEPDYWGRRKLAYEIAGKTEGNYVVVKYTAEPATSDELDRVLNLNESVIRTKILRKG
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: NDLMS_EUBBA
Sequence: MGKDYQVLGKNKVKVDSLEKVMGTAKFAADYSFPDMLYAGVFRSTVPHARIVSLDLSKARAIDGVEAVLDYHAIPGKNRFGIIIKDEPCLVDDKVRRYGDAIAVVAAQTPDLVQEALDAITIEYEELEGIFTMERALEEDSPAIHGDTNIHQVKHLEYGDVDAAFKQCDIVVEDTYSTHRLTHMFIEPDAGVSYYDNEGMLTVVVSTQNPHYDRGEVAGMLALPNSKVRIIQATTGGGFGGKLDLSVQCHCALLTYHTKKPVKMVRSREESTTVSSKRHPMTMHCKTGATKDGRLQAVQVEMFGDTGAYASYGPAVITRATVHCMGPYVVPNVRVDAKFVYTNNPMSGAFRGFGVPQASVCHEGQMNALAKALGMDPIDIRILNAHQVGAKLATGQVLENSVGLIETLEKAREKAVEVMGYEKTR
What is the function of this protein?
Catalyzes the hydroxylation of nicotinate to 6-hydroxynicotinate.  Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs.
What are the official names of this protein?
Nicotinate dehydrogenase large molybdopterin subunit, NDH, Nicotinic acid hydroxylase large molybdopterin subunit, NAH.
What is the protein family that this protein belongs to?
Belongs to the xanthine dehydrogenase family.
Protein: DCTA_BURO0
Sequence: MKKKPFYKVLYVQVIFAIIVGVILGHFYPSIATDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALLYFEIVSTFALLLGLAATHLLRPGVGFNIDPATLDGKAVASYAAKAHGQSTVDFLMHIIPNTMVDAFAQGEILQILLIALLFGSVLAHLGERGRVVTDFIDGLTRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLGAIARFTGFSIIRFVSYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQATNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSAWEKELDRNKLRQALKGGGEVAPTETTAGV
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
Protein: RPFB_MYCS2
Sequence: MLRGVVGAFLVSLTVAGSYAVASHKTVTLSVDGAPMTVTTMKSRVIDIVEENGFEVSDRDDLFPAATETVHQSDTIVLRRSRPLEVSLDGEGTKQVWTTASTVDEALAQLRMTDKAPAAASRGSRVPLAGMALPVVSPKTVQIDDGGKVSTVHLAAPNVAGLLEAAGVPLEQNDKVVPAASSPVVDGMQIQVTRMRIEKVTERVPLAPGNERIEDPTMNMSRQVVEDPGAPGLQDVTFAIAKVNGVETGRLPVANQVIEPARNGVLRVGAKPGTEVPPVSNGHTWDALAQCEAGGNWAINTGNGFYGGVQFDQNTWERNGGLRYAPRADLATREEQIAIATVTQSRQGWGAWPVCSGRIGAR
What is the function of this protein?
Factor that stimulates resuscitation of dormant cells.  Has peptidoglycan (PG) hydrolytic activity.  Active in the pM concentration range.  Has little to no effect on actively-growing cells.  PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity (By similarity).
What are the official names of this protein?
Resuscitation-promoting factor RpfB.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase family. Rpf subfamily.
Protein: RLME_ACIAD
Sequence: MATRITNQKLSKSSRAWMREHLDDPFVKKAQKEGYRARAAYKLLEIQEKYRLIKPGMTVVDLGAAPGSWSQIAGKLVGSKGLVIASDILAMDTLPDVTFLQGDFREEEVFEKLLNILNGRTVDIVISDMAPNTSGNRAVDQPRQIYLCELALDFAQKVLGPDGQFVVKVFQGSGFDEFRKQVVDSFDVLKTVKPAASRARSKEVFLIGQGRKKALQ
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADCY1_MOUSE
Sequence: MAGAPRGQGGGGGAGEPGGAERAAGPGGRRGFRACGEEFACPELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCILFLALFVVTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGGAMGSTVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILAALFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQCFPGCLTIQIRTALCVFIVVLIYSVAQGCVVGCLPWAWSSQSNSSLVVLAAGGRRTVLPALPCESAHHALLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLCTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDGNSSHGRTFRLERRMCPYGRGGGQARRPPLCPAAGPPVRPGLPPAPTSQYLSSTAAGKEA
What is the function of this protein?
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.  Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:9662407, PubMed:7816821).  May be involved in regulatory processes in the central nervous system (PubMed:9662407).  May play a role in memory and learning (PubMed:7816821).  Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (PubMed:24048828).
What are the official names of this protein?
Adenylate cyclase type 1, ATP pyrophosphate-lyase 1, Adenylate cyclase type I, Adenylyl cyclase 1, Ca(2+)/calmodulin-activated adenylyl cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Membrane raft. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia|.
Protein: OCA1_PICGU
Sequence: MSRKVVQPPSLRIIPPLNFCPVEKQLYRSGQPSIINQSFLQDLNLKTIIWLASEEPQEEFLDYCSMNSINIEFVGMINDDYSYQNVNPWDSLNETTIKKALELICDRNNYPMLVCCGMGRHRTGTVIGCLRRLQGWNLASVSEEYRRFTGARGGRILVELLIEGFDISTVEIGSGKGSSMARKKR
What is the function of this protein?
Putative tyrosine-protein phosphatase required for protection against superoxide stress.
What are the official names of this protein?
Putative tyrosine-protein phosphatase OCA1.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTI_XANC5
Sequence: MHCDVLWHNAQLMTLDAADGGLGIVDDGIVACRHGHIVYAGAAAQAPALQPDSAHDCRRRWISPGLIDCHTHLVYAGNRANEFEQRLRGASYADIAAAGGGIVATVRATRAADDAALLAASLPRLDAMLGEGVTTLEIKSGYGLTLDDEVKQLRVARQLAALRKVEVVPTFLGAHAVPPGGQAQHYIDQVCTQMIPAIATQGLAEAVDVFCEHLAFSQAQAEKVFVAAQAHGLRIKIHAEQLSNQHGAELAARYGALSADHIEYLDQTGIAAMAAAGTVAVLLPGAFYFTRDTQLPPIAALRTAGVPLALATDCNPGTSPLTSPLLAMNMAATLFRMTVDECIAGFTREAARALGRSERLGQLRAGMDCDLAIWNIDAPADLVYRMGFNPLHARVWRGHLC
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_STRT2
Sequence: MMKKFLIALVKAYQRWISPLFPLSCRFCPTCSVYMIQAIEKHGLKGVLMGIARILRCHPLSETGDDPVPDYFSLKRKKTPLDN
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DNLJ_LISMC
Sequence: MADKKRYEELINILDQYSYDYYVIDNPTVEDAEYDQKMQELLKIEEAHPEWVTPESPSKRVGGEVLEGFKKVAHDTPMLSLANAFNQEDLADFDRRIRDKVGDDIAYMCELKIDGLAVSLQYENGKYKQGATRGDGTIGEDITANLRTIRSIPMKLQKDYSIEVRGEAFMPKRSFQKLNEIREEEGQMLFANPRNAAAGSLRQLDTKIAASRNLDIFLYAVADFGEMGVETHSAGLDMLETLGLKVNKERRLCNSLEEVYAYIEEWTEKRAGLAYDIDGIVLKLNNLEQQRQMGNTVKSPRWSIAYKFPAEEVPTKLLDIELNVGRTGVITPTAVLEPVRVAGTTVSRASLHNEDLITEKDIRIGDTVLIKKAGDIIPEVIKSITEKRSGSEEPFHMPKNCPACDSELVRLEEEVALRCINPKCPAQIKEGLIHFVSRNAMNIDGLGEKVIIQLFSQHLIKDVADLFFLSKEKLLELERMGEKSVTNLLASIEASKQNSLEKLLFGLGIRHVGAKAAKSLAIHFDTMDNLKVADKETLTSINDIGEKMADSIVTYFANEEVHDLLEELKRAGVNMTYTGPKLEDMSEEELVFAGKTVVLTGKLEKLTRNDAKALIESLGGNVSGSVSKKTDVVVAGSDAGSKLAKAEELAIPIWSEEDLIEYLPDEGGLNE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: MATK_STYHA
Sequence: MKKYQRYLELDRSQQQNFLYPLIFREYIYGLAPSHDLNRNRYILSENVDYDKNSSLLIVKRLITRIYQQNHLILFDNDSSKNQFWGYNKNLYSQIISEGFAIVMEIPFSRQLSSSLEEAGIVKSFNNLESIHSIFSFFEDKFTYLKFFSDVRIPYPIHLEILVQTXXXXXXXXPLLHLLRLFLYEYCNWTSLITQKKIIFTFSKSNPRFFLFLYNFYVCEHESIFLFLRKKSSHLRLNSFSVFFERIYFYTKLEHLVEVFSKNFSSTLSFFKDPLIHYVRYQGKSIFASKNAPFLMNKWKYYFIYFWQCYFDIWSQPRMIQINELFENSFHFFWGGYLSNVRLNFSVVRSQMLEDSFLIEIVMKKLDTIVPIIPLIRSLAKAKFCNRLGHPISKPVWTDSSDFDIIDRYLRICRNLSHYYNGSSKKSLYRIKYIIRLSCIKTLARKHKRTLRAFLKRLDSEELLEEFFTEEEEILSLIFPRSSATLRRLYRSRIWYLDILFSNDTINVN
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.