PharMolix/UniProtQA huggingface dataset:
Protein: NU3C_PROMS
Sequence: MFLLTGYEYFLGFLLIAAAVPVLALVTNLIVAPKGRTGERKLTYESGMEPIGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFNRLGLLAFIEALIFIAILVIALAYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: Y488_ARCFU
Sequence: MKRLIFVIGVFIVALALSAFHWVGIIIGGLIVGYFSKNLKEAVAAGLALSLFIFGAFLAYLAYMGMLEKFLTLSPLPYISILLCMALAVISATITNFFSPFAVKQS
What are the official names of this protein?
Uncharacterized protein AF_0488.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLGH_BARBK
Sequence: MYLVFGIIFTSVIVTSCSYNTKDFNSVPDFSPVRADLGYAPSRTAQTYPLPPRESNYSLYRASGNSFFRDPRAMQPGDVLTVQISINDRASLNNKSDLKSDSSSKYTIGTGYSFMDRIAGSLEGESSNQSKGDGKIERQENIRLSVAAIVTDVLPNGNLIIRGSQEVRVNHELRILNIAGVVRPRDISGNNMIEYDKIAEARISYGGRGRISEIQQPPYGQQLLNQISPF
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor. Bacterial flagellum basal body.
Protein: IMP4_RAT
Sequence: MLRREARLRREYLYRKAREEAQRSVQEKKERVKRALEENQLIPTELRREALALQGSLEFDDAGGEGVTSHVDDEYRWAGVEDPKVMITTSRDPSSRLKMFAKELKLVFPGAQRMNRGRHEVGALVRACKANGVTDLLVVHEHRGTPVGLIVSHLPFGPTAYFTLCNVVMRHDIPDLGTMSEAKPHLITHGFSSRLGKRVSDILRYLFPVPKDDSHRVITFANQDDYISFRHHVYKKTDHRNVELTEVGPRFELKLYMIRLGTLEQEATADVEWRWHPYTNTARKRVFLSAE
What is the function of this protein?
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP).  Required for the early cleavages during pre-18S ribosomal RNA processing.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
U3 small nucleolar ribonucleoprotein protein IMP4, U3 snoRNP protein IMP4.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HUTI_SHEDO
Sequence: MSWDQVWIDINIATMDANIGEPYGAITQAAMAVKDGKIAWLGPRSELPEFDVLATPVYRGKGNWVTPGLIDAHTHLVFAGSRANEFELRLKGASYEEIARAGGGIISTVKACREADEAELFELGRQRLNALAKEGVTTVEIKSGYGLDIETELKLLRVARELGKHHHVDIKTTFLGAHAIPSEYKDAANSTERSDAYVDLVVNEMLPAVMAENLADAVDVFCEGIAFNLAQTKRVFTAAKQAGLDIKLHAEQLSNIGGSQLAAQMGALSVDHIEYLDEAGVKALSESGTCAVLLPGAFYFLRETKLPPIDLLRQYKVPMVVASDYNPGSSPICSSLLMLNMACTLFRLTPEEALAGMTVNAAKALGIGDNVGHLAVGMQADFCLWNISSAAELAYSYGVDRLIDVVKTGKLVHQ
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BHE40_MOUSE
Sequence: MERIPSAQPPPTCLPKAPGLEHGDLSGMDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGRNLEAGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGSEGPGKNCVPVIQRTFAPSGGEQSGSDTDTDSGYGGELEKGDLRSEQPYFKSDHGRRFAVGERVSTIKQESEEPPTKKSRMQLSEEEGHFAGSDLMGSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNTSAAALSSFMNPDKIPTPLLLPQRLPSPLAHSSLDSSALLQALKQIPPLNLETKD
What is the function of this protein?
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:18411297).  Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706).  Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (By similarity).  Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (By similarity).  Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706).  Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558).  May function as a transcriptional factor for neuronal differentiation (PubMed:9284045).  Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (By similarity).  Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868).
What are the official names of this protein?
Class E basic helix-loop-helix protein 40, bHLHe40, Class B basic helix-loop-helix protein 2, bHLHb2, Differentially expressed in chondrocytes protein 1, DEC1, E47 interaction protein 1, EIP1, Stimulated by retinoic acid gene 13 protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus (By similarity).
Protein: RHAR_SALPA
Sequence: MANQLILLKKDFFTDEQQAVTVADRYPQDVFAEHTHEFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVNDLVLQNIIYCPERLKLNVNWQAMIPGFQGAQWHPHWRLGSMGMNQARQVINQLEHESNGRDPLANEMAELLFGQLVMTLKRHRYATDDLPATSRETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWRHLSNQSD
What is the function of this protein?
Activates expression of the rhaSR operon in response to L-rhamnose.
What are the official names of this protein?
HTH-type transcriptional activator RhaR, L-rhamnose operon transcriptional activator RhaR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_RUEPO
Sequence: MRRKLAAGNWKMNGTGAALDALEAIAGAHSAAAVDLLICPPATLLYRAAQVAEGSRVRIGGQDCHAVTAGAHTGDISAMMLADAGASAVILGHSERRADHGETDAQVCDKARAALEAGLIAIICIGETLAQREAGQTLDVVCAQLAGSVPDGIDGTRVVVAYEPVWAIGTGLVPTLEQIAEVHDTLRQQLIGRFGSETAEAIRLLYGGSVKPGNAAEIFAVSNVDGALVGGASLTAADFSPIVSALEQAAG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NNJA2_MAIZE
Sequence: MWSPIPGTLMRTSSLPAVIEASGNDDWKKRKEAQSLKRLEVKKKRIERRNSLACNTSKEAAGQSPKEMNANTDKLVSSDETIVSANESHSSGKHLVKGLPPKYQATITSEDSSSAMRKKPNSAFKGTAITEEQNSSSSVPSSGEAISSVTAPSLPLLSLVPITATLGSREDQSILGRAGARANGMGDVERRMMQEMPGVFTKGLSNGSRVEGFLYKYSKGEVRIVCICHGSFLTPSEFVEHAGAGKVDNPLRHIVVSATPNL
What are the official names of this protein?
Ninja-family protein 2.
What is the protein family that this protein belongs to?
Belongs to the Ninja family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS14Z_LIMRJ
Sequence: MAKKSMIAKCNRPAKFSSREYTRCARCGRPHSVYRKFHLCRICLRELAHKGQIPGLKKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14 type Z.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
Protein: Y879_POLSJ
Sequence: MLHYSVVFLVIALIAAIFGFGGIAAGAVEIAKILFFIFAIMAVVSFVMGLIKKN
What are the official names of this protein?
UPF0391 membrane protein Bpro_0879.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DCTA_BURM1
Sequence: MKKKPFYKVLYVQVIFAIVVGVILGHYYPSLATEMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMEDMKKVGRVGGKALLYFEIVSTFALVLGLAATHILRPGVGFNIDPATLDGKAVASYAAKAHGQSTVDFLMHIIPNTMVDAFAQGEILQILLIALLFGSVLAHLGERGKVVTDFIDGLTRVLFGIVHIVTKLAPIGAFGAMAFTIGKYGVGSLVPLLKLIGTFYLTSVVFVLVVLGAIARFTGFSIIRFVSYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQATNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSAWEKELDRAKLRQALKGGGEVAATETAGV
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: APAH_SHIB3
Sequence: MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLQTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIYALDTGCCWGGTLTCLRWEDKQYFVQPSNRHKDLGEAAAS
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: LPXD_AGRRK
Sequence: MEHIGFFPPHDGVSLRALAEHLGAELADEAFAGVIIKSIAPVYRAGDGDVCYLLSRKNRAELETCKASAIICLPTLSSLVPEHIPVLLSKKPHTDFALAGALLHPQAMRPVALTSTPTLISPTAFVDPTAKLEADVGVEPGAVVGPGAEIGEGTRIGAGAIIGPGVKIGRHCTIGGGASVLCSYLGNGVIIHNGARIGQDGFGYAPSPRGMIKIVQIGRVIIQDNVEIGANTTIDRGTMDDTVIGEGTKIDNQVQIGHNVRIGRYCAIVSQVGIAGSAVIGDGVQIGGHTGINGHIQIGDGVQIGAMSGVMNSIPAGERFAGIPARPLWDFLREAAEVAKRSGAREKKDGSAEHD
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
Protein: Y0652_DICDI
Sequence: MWKFTSSATKRIGNSLSSNNNNGSLLFSLNFNGSNNNNNNESSKPITAANTQNNSTTKSIDNNNNNTNNSNSNNNNNDNIKNNNKFNRASHRSNITLVAINNKDISQMTNLLADSGISVSKISNKKISLASKINTLNKLNSSLLHLNSINNSLTNSNNNNDNNNLIDNNNNDNYNNDSISSSSSSSSLSESSQTLSSASSSASSSSSSTLSSSSSVSSKSLNNNNNNNNSRFNNEFNDVRVLGKGGFGIVFQCCNIFDQMEYAVKRIKVNQKIPTKELMEVRAMARLNHPNIVRYYGSWIEEEIITNNSIDHYGENDNNLFENIDSFPSSSYSSVSAAASSSSLVSNSSNSYSNNKATYISNSSSSSSSSSSCSYSIGNGNLSISECTNDDNNNYNQLKQKKFSLYIQMELCKYSTLRNLINEINNIKSITSIQSTSSIANPIGTNILISLDIKQCREITRQILVALKYIHSQGFVHRDITPDNVFVCQSPFGIKIGDFGLATTIESLTVDSNNNNNNNINNNNNNNKKVGGLGTYLYSSNEQEQGDNYNQKTDLYSVGVIFFEMLSQFKTTMERSTTLSKLKKSLSVLKTNPNLKQKYPNDTDFIDHLIQSFATRPFSNQISTDYDNFPPKNFLIN
What are the official names of this protein?
Probable serine/threonine-protein kinase DDB_G0283065.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Protein: PDXT_NITMS
Sequence: MSAKIGILAIQGDVAENVSSLVASIADLNQDATVHVVKTPEEISAMDGLVIPGGESTTIGQLSLVNGSQKVIKQKVESGMPVLGICAGMVLLASNATDRVVGKTEQPLFDFLDIELERNSFGRQRESFEANVSMDSIGISNYNGVFIRAPAISSTSDDIEVLAKLNEKIVAIKKGNIIGTSFHPELTDDLAVHKYFVNLVKETKQ
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: EFTS_STRSY
Sequence: MAEITAALVKELREKSGAGVMDAKKALVETDGDIEKAIELLREKGMAKAAKKADRVAAEGLTGVYVDGNVAAVVEVNAETDFVAKNAQFVELVNTTAKVIAEGKPADNEAALKLAMPSGETLEEAYVNATATIGEKISFRRFALVEKTDAQAFGAYQHNGGRIGVISVVDGGDETLAKQISMHIAAMKPTVLSYTELDEQFVKDELAQINHKIEQDNESRAMVNKPVLPLLKYGSKAQLTDEVIAAAEEAIKAELAAEGKPEKIWDKIIPGKMDRFLLDNTQVDQAYTLLAQVYIMDDSKTVEAYLNSVNASVVEFARFEVGEGIEKASNDFEAEVAATMAAALGK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X_HBVD4
Sequence: MAARLCCQLDPARDVLCLRPVGAESRGRPVSGPLGSLSSSSPSAVPTDHGAHLSLRGLPVCAFSSAGPCALRFTSARRMETTVNAHQILPKILHKRTLGLSTMSTTDLEAYFKDCLFKDWEELGEEIRLKVFVLGGCRHKLVCAPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: THIG_ALTMD
Sequence: MLTLANHTFSSRLLTGTGKFSNATTMKSAVSAAQSNIVTLAMKRVASNNAQDETLKALRELGVTLLPNTSGAKNAQEAVFAAELSYEALGSQWVKLEIHPDQRYLLPDPIETLRAAETLVKKGFNVLPYCGADPVLCKRLEDVGCAAVMPLGAPIGSNQGLQTAPFLKIIVEQASIPVIVDAGIGKPSEAMAVMEMGVDAVLVNTAIATARNPVAMAKAFASAVETGRCAFEAGLGATSNVALASSPLTAFLEPTV
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 6HN3M_PSEFL
Sequence: MSQSPRIAVVGAGLGGAAAAKLLLQEGFNVRVYEQAPSFSRLGAGIHVGPNVMKILRRIGIEDALNEQGSHPDYWYSRHWQTGDVLAQIPLGDYAVKEYGASYLTVHRGDFHALLVEALPDSVMAYGKFLTKVEDRGNVVVMHFADGTTEEADIVIGPDGVNSRIREELLGPELPKYAGYLAHRAVFPTPEVKAGMLPFDACVKWWSDDRHMMTYFVTGKADELYYVTGVPVEKWDLNDRWLESSKEEMREAFSGWHPTVQALIDATVEVTKWSLLERDPLPLWSRGRLVLLGDACHPMKPHMAQGAAMAIEDGAMLARCLKEVGAHNHELAFALYEANRAERASKVQRISHDNTWLRTNEDPSWCFGYDVFNVPLVEPKVKAAA
What is the function of this protein?
Flavin-dependent monooxygenase (FMO) that catalyzes the decarboxylative hydroxylation of 6-hydroxynicotinic acid (6-HNA) to 2,5-dihydroxypyridine (2,5-DHP) with concomitant oxidation of NADH, a step in the aerobic nicotinate degradation pathway.  Uses NADH in preference to NADPH as an electron donor.
What are the official names of this protein?
6-hydroxynicotinate 3-monooxygenase, 6-HNA monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the 6-hydroxynicotinate 3-monooxygenase family.
Protein: MURD_RICBR
Sequence: MTIHKKQNIGVFGFGKTGISVYEELQSKCNIIAYDDLEVNRNKFEELFSKNYIIPISDIKWQNLDKIVLSPGIPLTHEIVKIAKNFNIPITSDIDLFFEKSKGLNLLAVTGTNGKSTTTALISHILSDNGLDYPVAGNIGVPVLQAKASKGGYVLELSSFQLDLVKTFAAKIAVLLNITPDHLDRHENMEGYITAKSKIFDRMDKDSYGIINIDNDYCHEIFTNLQQKHHIKLIPFSVTKILEKGISIVNDIITDNFFEHISFKLISNKSLQGIHNSENIAASYAVARIIGLEPVKIIESISSFQGLPHRMQYLGNIDDINFYNDSKASNAIAAVQSIKALDNIYWLAGGIAKEGGIEEIKPYFSKIKKAYFYGQAKEMFANTAKDIIDFVICDDLKQAFELAYKDACKDNEKEKNILLAPCCSSYDQFKNFEERGELFIRLYNTLNLCL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBB1_DISEL
Sequence: VHWTEKERTIITGIFSHMDYEDIGPKALSRCLIVYPWTQRHFSCFGNLYNAEAIMGNANVAAHGIKVLHGLDRGVKNMDNIVATYAELSILHSEKLHVDPDNFKLLSDCITIVVAAKMGHAFTGETQAAFQKFLAVVVSALGKQYH
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta-1, Beta-1-globin, Hemoglobin beta-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: POTF_ECOLI
Sequence: MTALNKKWLSGLVAGALMAVSVGTLAAEQKTLHIYNWSDYIAPDTVANFEKETGIKVVYDVFDSNEVLEGKLMAGSTGFDLVVPSASFLERQLTAGVFQPLDKSKLPEWKNLDPELLKLVAKHDPDNKFAMPYMWATTGIGYNVDKVKAVLGENAPVDSWDLILKPENLEKLKSCGVSFLDAPEEVFATVLNYLGKDPNSTKADDYTGPATDLLLKLRPNIRYFHSSQYINDLANGDICVAIGWAGDVWQASNRAKEAKNGVNVSFSIPKEGAMAFFDVFAMPADAKNKDEAYQFLNYLLRPDVVAHISDHVFYANANKAATPLVSAEVRENPGIYPPADVRAKLFTLKVQDPKIDRVRTRAWTKVKSGK
What is the function of this protein?
Part of the ABC transporter complex PotFGHI involved in putrescine uptake (PubMed:8416922, PubMed:23719730).  Binds putrescine (PubMed:8416922, PubMed:9651355).  Imports putrescine for maintenance of the optimal concentration of polyamines necessary for cell growth in the presence of glucose (PubMed:23719730).
What are the official names of this protein?
Putrescine-binding periplasmic protein PotF.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein PotD/PotF family.
What are the subcellular locations of this protein?
Periplasm.
Protein: NADE_YEAST
Sequence: MSHLITLATCNLNQWALDFEGNRDRILQSIKIAKERGARLRVGPELEITGYGCLDHFLENDVCLHSWEMYAQIIKNKETHGLILDIGMPVLHKNVRYNCRLLSLDGEILFIRPKIWLANDGNYREMRFFTPWMKPGVVEDFILPPEIQKVTGQRLVPFGDAVINSLDTCIGTETCEELFTPQSPHIAMSLDGVEIMTNSSGSHHELRKLNKRLDLILNATKRCGGVYLYANQRGCDGDRLYYDGCALIAINGTIVAQGSQFSLDDVEVVTATVDLEEVRSYRAAVMSRGLQASLAEIKFKRIDIPVELALMTSRFDPTVCPTKVREPFYHSPEEEIALGPACWMWDYLRRCNGTGFFLPLSGGIDSCATAMIVHSMCRLVTDAAQNGNEQVIKDVRKITRSGDDWIPDSPQDLASKIFHSCFMGTENSSKETRNRAKDLSNAIGSYHVDLKMDSLVSSVVSLFEVATGKKPIYKIFGGSQIENLALQNIQARLRMVLSYLFAQLLPWVRGIPNSGGLLVLGSANVDECLRGYLTKYDCSSADINPIGGISKTDLKRFIAYASKQYNMPILNDFLNATPTAELEPMTKDYVQSDEIDMGMTYEELGVFGYLRKVEKCGPYSMFLKLLHQWSPKLTPRQISEKVKRFFFFYAINRHKQTVLTPSYHAEQYSPEDNRFDLRPFLINPRFPWASRKIDEVVEQCEAHKGSTLDIMSID
What are the official names of this protein?
Glutamine-dependent NAD(+) synthetase, NAD(+) synthase [glutamine-hydrolyzing].
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD synthetase family.
Protein: TSN12_HUMAN
Sequence: MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGSLLVIFCVELACGVWTYEQELMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNFFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQEDLSDLYQEGCGKKMYSFLRGTKQLQVLRFLGISIGVTQILAMILTITLLWALYYDRREPGTDQMMSLKNDNSQHLSCPSVELLKPSLSRIFEHTSMANSFNTHFEMEEL
What is the function of this protein?
Regulator of cell surface receptor signal transduction.  Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction.  Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs.  Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity).  Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP.  Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP).  Activates MMP14/MT1-MMP-dependent cleavage activity.
What are the official names of this protein?
Tetraspanin-12, Tspan-12, Tetraspan NET-2, Transmembrane 4 superfamily member 12.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GUAA_CLOPE
Sequence: MRDLVLVVDFGGQYNQLIARRVRECGVYCEIIPYTYSIEKIKEKNPKGIIFTGGPNSVYGENTPTLDKEIFNLNVPVLGICYGDQLMAHLLGGKVDTAPVREYGKTNVTLDNSSKLFAGIEADETCWMSHTDYIAEAPEGFKIIAHTDVCPVAAMENEERRLYGVQFHPEVEHTPFGQNMMRNFLYNICGLENSWSMASFAEEKIAEIKKIVGDKKLICALSGGVDSSVAAVMVHKAVGKQLTCIFVDHGLLRKDEGDQVEKIFKEGFDMNLIRVNAQDRFLGKLKGVSDPETKRKIIGEEFIRVFEEEAGKLGDIKFLVQGTIYPDVVESGTDTSAVIKSHHNVGGLPEDMEFSLIEPLRELFKDEVRAVGEELGIPHHLVWRQPFPGPGLAIRVLGEVTEDKLEVVREADAIFREEIALAGLESEIWQYFAVLPNIQSVGVMGDERTYCHTVGLRAVTSSDGMTSNWAHIPYEVIDKVSRRIVNEVKGVNRIVYDVTSKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.