PharMolix/UniProtQA huggingface dataset:
Protein: ANN1_AREMA
Sequence: MTSTQSVAVCATLILAIFCVNDIHCDPIAEARAAAFGEREARSDGEWKQFDVNGEKIEVNEQENREIIRQAGGDGVEGSVMVIDHAKGLISWSIPRAGECYLIGGVDKQLPDAQELLHYFQSAQGSADGEGVESALDYVKAEDRPVTDLNLLAPEVREACQGKSVYWLEKSSGDNNEPEKRRWCVYAYVRVRGVLVRYRRCW
What is the function of this protein?
Has antimicrobial activity against the Gram-negative bacteria E. coli and P. mirabilis, the Gram-positive bacterium L. monocytogenes and the yeast C. albicans.
What are the official names of this protein?
Arenicin-1.
Protein: RATA_RICPR
Sequence: MLSFQHTKILPYKPKKLFDLVWDIKSYPQFLPWCAAARIISENNQEVISELVIQLKGLSEKYNSRVINTITDNGIYLIDTVAISGPFEYLKSTWQFIPHSTGTELKFFINFKMTSVILDKLIGSYFTIATEKMILAFEKRAKEVIK
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes.  Its antitoxin is unknown (By similarity).
What are the official names of this protein?
Ribosome association toxin RatA.
What is the protein family that this protein belongs to?
Belongs to the ribosome association toxin RatA family.
Protein: HIS52_PARMW
Sequence: MGLHLGLIDYGMGNLHSVEKAFNRLGHQPSRVVNPSDLDGCDALVLPGVGSFDPAIDNLQSTGLIPDLKRWNEADRPLLGICLGLQLLFESSAEGRLEGLGLIKGHVERLPIGAGARIPHMGWAPLDLRRANPMLAAADPLAWVYFVHSYAAVPERPETLAAAASFGSSSVTAMVWQRRLGACQFHPEKSSDSGSAMLKRWLDWLQRGAPIG
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity).
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH 2, IGP synthase glutaminase subunit 2, IGP synthase subunit HisH 2, ImGP synthase subunit HisH 2, IGPS subunit HisH 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MACB2_ECOK1
Sequence: MKKLIELKGVSRTYGNGDQTRTVLKNVDLTIVAGEMVAIIGASGSGKSTLMNIMGCLDVPNRGDYYIDGQNAACLSPDELARVRREHIGFIFQRYHLIPDLSALGNVEIPAIYANSERDSRRQRATALLGRLGLEGREHHKPCELSGGQQQRVSIARALINGGKIILADEPTGALDSQSGQEVLAILNELNRRGHTVVMVTHDMKVARHAKRIIELCDGEIIADSGGCVSATETLPKTNRIRQSYWKTLLDRTRESMQMALKAMKTHRLRTTLTMIGIVFGIASVVTVVALGEGARQETLEEIKSLGTNVVSIYPGQDLFDDSIESIRTLVPADANALAKQGFIDSVSPEVSASDNIRFLGKSAIASINGVGREHFRVKGIELLQGTTFRDDRNALQEVIIDENTRKAIFDNTGLQALGQIVFLGSVPARVVGIAKSNNRSDASNRITVWMPYSTVMYRIVGKPVLTGISVRLKDNVDNEAAISAISQLLTRRHGIKDFQLYNFEQIRKSIEHTSMTFSILILMVACISLMIGSIGVMNIMLISVTERTHEIGVRMAVGARRSDIMQQFIIEAVLVCLIGGALGIALSYITGALFNALADGIFAAIYSWQAAVAAFFCSTLIGIIFGYLPARKAARMDPVISLASE
What is the function of this protein?
Part of the tripartite efflux system MacAB-TolC.  MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UBIE_ECOL6
Sequence: MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKTMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: RUVB_XANC5
Sequence: MTEQRIIASSSTREDDAADASIRPKRLADYLGQQPVREQMEIYIQAAKARGEAMDHVLIFGPPGLGKTTLSHVIANELGVSLRVTSGPVIEKAGDLAALLTNLQPHDVLFIDEIHRLSPVVEEVLYPAMEDFQIDIMIGDGPAARSIKIDLPPFTLIGATTRAGLLTAPLRDRFGIVQRLEFYSPQELTRIVSRSAAILGIDCTPEGAAEIARRARGTPRIANRLLRRVRDYAQVKAAGHIDLPVAQAAMQMLKVDPEGFDELDRRMLRTIVEHFDGGPVGVESLAASLSEERGTLEDVIEPYLIQQGFLIRTARGRMVTPKAYLHLGLKVPRERAPGIGEPGDLF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: SYY_STAEQ
Sequence: MANALIEDLKWRGLIYQQTDEEGIEELLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRFQEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTESQVEANVKGLSNQMHRLFEFGSDKGAKLVNNKDWLGQISLISFLRDYGKHVGVNYMLGKDSIQTRLEHGISYTEFTYTILQAIDFGYLNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTEAYGLTIPLVTKSDGKKFGKSESGAVWLDPEKTSPYEFYQFWINQSDEDVIKFLKYFTFLEKEEINRLEQSKNEAPHLREAQKALAENVTKFIHGEAALKDAIRISKALFSGDLKSLSAKELKEGFKDVPQVTLSTKTTNIVEALIETGIASSKRQAREDVNNGAIYINGERQQSVDYELSSKDLIEDEITIIRRGKKKYFMVNYQS
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_COREF
Sequence: MTSDETLAVLIRYLDNPNPTVEEAVEVFTPMTIGEYDDVHIAALLATIRTRGETFADIAGAAKAFLNAGRPFPVPGTGVLDTAGTGGDGANTINITTGASLVAAAGGLKVVKHGNRSVSSKSGSADVLEALNIPLDLDPERAQRWFEASNFTFLFAPAYNPAIAHAQPVRKALKVPTIFNVLGPLLSPVRPEFQIMGVANPRHGQMLTEVFRELGRTRALVVHGAGTDEIAVHGTTQVWELKADGEIISYEITPEELGVERCDLTDLVGGDGVENARHMRAIFDGTGPAAHRNAVAVNAGAMFYLNSQADSLREGTAHALSLINDGTVADWLKTHEEIDYRG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: RNB_SALNS
Sequence: MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIVAVIHTEKERESAEPEELIEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVQHEFKEGDWAVAEMRRHPLKGDRSFYADLTQYITFADDHFVPWWVTLARHNLEKEAPNGVATEMLDEGLERQDLTALNFVTIDSASTEDMDDALYAEELADGRLQLTVAIADPTAWIAEGSKLDNTAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPALACRMIIAADGTIDDDIAFFAATIESKAKLAYDNVSDWLENNGTWQPENEDIAQQIRLLHRICLSRSEWRHHHALVFKDRPDYRFVLGEKGEVLDIVAEPRRIANRIVEESMIAANLCAARVLRDKLGFGIYNVHTGFDPANADALAALLKTHGLHVDAEEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTEPGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGEAIARPQEDITQQMAERRRLNRMAERDVGDWLYARFLNDKAGTNTRFAAEIIDVSRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPAA
What is the function of this protein?
Involved in mRNA degradation.  Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.
What are the official names of this protein?
Exoribonuclease 2, Exoribonuclease II, RNase II, Ribonuclease II.
What is the protein family that this protein belongs to?
Belongs to the RNR ribonuclease family. RNase II subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_SHEWM
Sequence: MSEIQLRHDWKRDEIEALFALPMNDLLFEAHSIHRQVYDPNEVQISRLLSIKTGACPEDCKYCPQSARYDTGLEKERLIEIEKVLTEARSAKAAGASRFCMGAAWRNPHARDMPYLKDMVREVKSMGMETCMTLGMLSPDQAGELAEAGLDYYNHNLDTSPEYYGDIITTRTYQDRLDTLSNVRAAGMKVCSGGIVGMGEQATDRSGLLQQLANMEQHPDSVPINMLVKVAGTPFENLEDLDPLVFVRTIAVARILMPHSRVRLSAGREKMSDEMQAMCFFAGANSIFYGCKLLTTNNPEENEDMTLFKRLGLHPEQGKYATIEDDKAVFEKATAKANAIKDKQSSAFYDAAAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: CYB_CAPMR
Sequence: MTNIRKTHPLMKIINNAFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTTTAFSSVTHICRDVNYGWVIRYLHANGASMFFICIYAHMGRGLYYGSHAFRETWNIGVILLFTTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIILALAAVHLLFLHETGSNNPTGIPSNMDKIPFHPYYTIKDILGVLLLILTLLMLTLFTPDLLGDPDNYTPANPLSTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLFSILILALIPMLHTSKQRSMMFRPFSQFLFWVLVADLLTLTWIGGQPVEHPYVMVGQLASILYFFLILILMPVTSLIENKLMKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HUTG_HALSA
Sequence: MFQNATDWTPTSTDPRDEQFGGVVEPVPTPSDADDYDAVLVGEPYDGAVIGRRGARDGPSAIRESLAGVKTHHFDAGAVSGVADLGDVVLPDGDVADTQAAVREAAAEVHETAALPVFVGGDNSLSYANVAPLVAADNGAVGVVSVDAHLDCRAVGDRGPTSGTPYRQLFDAGLDALAVVGARHFETTTTYAGFLRDQGGRIVTSDAVAADRDGSLDAAREALDGVDHVYVSVDIDVLDAAYPGASAPTPGGIQPRELFALVEALAASDDRIRGFELVETAPTLDTGGRTVDAAARTIAHFLAGAQ
What is the function of this protein?
Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.
What are the official names of this protein?
Formimidoylglutamase, Formiminoglutamase, Formiminoglutamate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: KVD37_HUMAN
Sequence: MDMRVPAQLLGLLLLWVPGARCDIQLTQSPSSLSASVGDRVTITCRVSQGISSYLNWYRQKPGKVPKLLIYSASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYGQRTYNAP
What is the function of this protein?
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains (PubMed:24600447).  Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) (PubMed:9619395).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Probable non-functional immunoglobulinn kappa variable 1D-37.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: DEFI_ORYRH
Sequence: MSRFIVFAFIVAMCIAHSLAAPAPEALEASVIRQKRLTCDLLSFEAKGFAANHSLCAAHCLAIGRKGGACQNGVCVCRR
What is the function of this protein?
Shows very strong activity against S. aureus.
What are the official names of this protein?
Defensin.
What is the protein family that this protein belongs to?
Belongs to the invertebrate defensin family. Type 1 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RS7_ECOL5
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYSALETLAQRSGKSELEAFEVALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAAENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ABIL2_ORYSJ
Sequence: MVEAVASFRRGGVGIAGMSSSTLEEVQMQETLIFSDTIKDLKMLKSQLYSAAEYFELAYTQEDDKQEVMNNLKEYSVKALVNTVDHLGSISFKVSSLIDQRFDEVDDTNLRVSCIHQRAQVSQACMDKEGLSQQSLVITAPKYHKRYILPAGDGSMPNAVPNFSEMRKAKNRAAQMQQVFSAAAASQAKAKEKQPSFSKLRSIARAPSQRARSSSPAQRPPSENTIPTKRADKRSESPIPRTTPLTRSGSLPQKPSLLKTSSVRVQMHTSEHKKLASVRSQADRNDDKEGEQTPKKGKKFLKSLLSRRKSRKEEPLPCYFDDY
What is the function of this protein?
Involved in regulation of actin and microtubule organization.  Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
What are the official names of this protein?
Putative protein ABIL2, Abl interactor-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the ABI family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: AKTR3_ALTAL
Sequence: MLQCAPKKNERLRGSCDFCTQSKLRCNKNKPSCRRCTIQQQPCVYSVARRTGRPPKHPRTANDCQEANGQHGEQDPVTSTPGGSCQQQSNHLLDVEGDGANFTLADASTTAQGRETPASSALDNALLVGETFGFSSLLDDPLIQSDDFLSFSLCMPPGEEEGHMASPRALNGSTGPCSPTVLSSIDVPHLPARFGFLESSVESGLHGRTGPHLVEQPDKIVPSSFSEMEKIYDEGLTFSGLDSAINAVTNNGKGEPSASGTMAAHPHSKRQCFCSTSMSKLQMLISHPTLCQKNSRARFDMTLFLEEVVFNIHRDVLQCLVCQSKSLHSLASLCICTDWVIEALRDVAQDLSSGQDNLGGFRAGLCPPKDKFSICVGRFVLDDQLRESCTRSLVKYRLRKLVPIMDTMMKLNYRGAGGALSQAIRTMVEDVRHKIESALGMMEL
What is the function of this protein?
Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AK-toxins responsible for Japanese pear black spot disease by the Japanese pear pathotype (Probable).  AK-toxins are esters of 9,10-epoxy 8-hydroxy 9-methyldecatrienoic acid (EDA) (PubMed:22846083).  On cellular level, AK-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).
What are the official names of this protein?
Transcription activator AKTR-3, AK-toxin biosynthesis regulator 3.
What are the subcellular locations of this protein?
Nucleus.
Protein: IDI2_MYCVP
Sequence: MTSDPGSALQHRKRRHIDVCLTEAVDYQSLTTGFERYRLPYNALTQTDLHSVDLSTEFLGSHLRAPVLIGAMTGGAALSGIINRNLAAAAQQLGIGMMLGSQRVMIDDEAAAASFEVRGVAPDILLIGNIGLAQLRSSMVPGLAAALDRVGANGLAVHTNPLQEAMQHDGDTDFSGSIGRLCDVAGAIGYPVVLKEVGHGIGAAAAAELVGCPIAAIDVAGAGGTSWARIEQFVRYGDVRYPALAEWGVPTAQALTEVRQMLPDVPLVASGGIRTGMDAAKALAMGARVVAVARPLLAPAVESVEAVVDWLQRFIDELLVCLHGCGAANLSALRGRGVTELP
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_EHRRG
Sequence: MINVYFSDNSCKQFLPGIKGSDIITHLFPELLNKAIAIKINDKSLDLSTEITEDCKFEVITLDSDEGLDIIRHDTAHIMAQAIKEMFPEVKTVVGPTIKDGFYYDFSTDHIFSSNELEKIEEKMREIIKKNESFIREVWTREEAIRFFSNKGEDYKVKIIAKIPIHENITVYKQGSFIDLCRGPHAPSTKISKAFKLTKVSGSYWEGNTNNAQLQRIYGTAWRTEEELKLYLNNLIEVEKRDHRKIGKELELFHIQNEALGQIFWHEKGLIIYRIIENYIRKKLENNGYIEVKTPYLLSKTLWEQSGHWDKFREHMFLSEIDNKVVAIKPMNCPCHVQIFNSKIRSYKDLPLRMAEFGTCHRYEASGALHGLMRVRSFTQDDAHIFCTEDQIIEEALKFCNLLMEVYEVFGFKDILVKFSDRPEKRAGSDKIWDKAEEALKASVKAANLNYVLNPGDGAFYGPKLEFTLKDAIGREWQCGTLQMDFVLPERLGAYYTGSDGKKHHPIMLHRAILGTIERFIGILIEHHSGKLPIWLAPVQLSILTITEDAIDYAISLKHKAMKQNIRAEVDITNEKINYKIRSHISKKIPVLWIIGKKEIETESVSIRYLESKDQHIMSSDKALKTLLSCASI
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_HV1VI
Sequence: MRVRGMQRNWQHLGKWGLLFLGILIICNAADNLWVTVYYGVPVWKEATTTLFCASDAKAYEREAHNVWATHACVPTDPNPQEVFLKNVTENFDMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLNCTNATNNSQEKPGAMQNCSFNMTTEVRDKKLKLSALFYRLDIVPIGNNNSSEYRLINCNTSTITQACPKVSWDPIPIHYCAPAGYAILKCNDKRFNGTGPCKNVSTVQCTHGIKPVVSTQLLLNGSLAEEGIVIRSQNISNNAKTIIVHLNESVQINCTRPNNNTRKGIHLGPGQTFYATGAIIGDIRKAHCNISGTQWNNTLEYVKAELKSHFPNNTAIKFNQSSGGDLEITMHSFNCRGEFFYCDTSGLFNDTGSNNGTITLPCRIKQIVNMWQGVGRAMYTSPIAGNITCNSNITGLLLTRDGGNESNIETFRPEGGNMKDNWRSELYKYKVVEIEPLGVAPTKAKRQVVQREKRAAGLGALFLGFLGDSREHMGAASITLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARVLAVERYLKDQQLLGIWGCSGKLICTTNVPWNSSWSNKSQEEIWNNMTWMEWEKEISNYSNIIYKLIEESQNQQEKNEQELLALDKWASLWNWFDISNWLWYIKIFIMIVGGLIGLRIVFAVLSIVNRVRKGYSPLSLQTLIPSPRGPDRPEGIEEGGGEQGKDRSVRLVTGFLALAWDDLRNLCLFSYRHLRDFILIAARIVDRGLRRGWEALKYLGNLTRYWSQELKNSAISLFNTTAIVVAEGTDRIIEVLQRAGRAVLNIPRRIRQGAERALL
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During fusion of viral and target intracellular membranes, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Complete fusion occurs in host cell endosomes and is dynamin-dependent, however some lipid transfer might occur at the plasma membrane.  The virus undergoes clathrin-dependent internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 env protein family.
What are the subcellular locations of this protein?
[Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag.
Protein: YC5C_SCHPO
Sequence: MLPRAYLRMTSTPKNLEKQPINFDNLPLYLQGTNYGENVLRSDPRWLKWEKYLREFDMTREGNVTNTPKAIPSSWNPNDKSDSLELMNNNMGVYFFGPEAGTEHDAASVKADHAIPSNTSIYYYEIQILSRGKEGKMGVGFCRKSMQTNRLPGCTAESWGYHGNSGEKFNCSKTGEAYGPEFTTGDIIGCGVNFINRTIFYTKNGAYLGVAFKKVSDVLYPVIGLKSHGEHVEVNFGQNPFLYDIDYAIQMEKNKLFEQATKSPKQEELKQRQEFLNELISSFLLNNGFVETAKKFCPENTEVSDASIRKEISSMLANGQLDLAMTKIDCQYPVAIQECPDLIMSLRFLRFLQLVKVTHDQRLTKSKGTKQISQEEDLRILQPLMNYAQELSNDYEHTKSSNLQAMIKLSMGLLAYFDPFSSPLSFFMSSDFHKYMAEQINCLLLELTGHSPDSELRRFLQHTVCLNDLLCRNGCRSNTLFNVQSDFLSPY
What are the official names of this protein?
Uncharacterized protein C1259.12c.
Protein: CYB6_MARPO
Sequence: MGKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFSSVQYIMTEVNFGWLIRSVHRWSASMMVLMMILHIFRVYLTGGFKKPRELTWVTGVILAVLTVSFGVTGYSLPWDQIGYWAVKIVTGVPEAIPIIGSPLVELLRGSVSVGQSTLTRFYSLHTFVLPLLTAIFMLMHFLMIRKQGISGPL
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family. PetB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL10_LISIN
Sequence: MSKVLEAKQSAVEEIKTKLSASASTVIVDYRGLNVGEITDLRKQLRDAGIEFKVYKNSLTRRAVEANGYEGLEGALTGPNAIAFSNEDVVAPAKILNDFAKDHEALEIKAGVIEGKVASLEEIKALATLPSREGLLSMLCNVLQAPVRGLAIATKAVADQKEGQEA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: RACA_BACC0
Sequence: MEYKTPFIAKKLGVSPKAVVRIAQQLNLTIEKNKYGHFIFTQDDLDQMLEYHRSQIEQSQNTHPTQKTSSNDVEELKTQVNTIVQNISSHDFEQLAAQLNTITRRLDRMEEQMQDKANDVVTYQLLQHRREMEEMLERIQKLEAGLKKEEPIYITPDTKPTYEREKKPKRRKMIFSIFGL
What is the function of this protein?
Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore.  Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure.
What are the official names of this protein?
Chromosome-anchoring protein RacA.
What is the protein family that this protein belongs to?
Belongs to the RacA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cell poles and nucleoid.