PharMolix/UniProtQA huggingface dataset:
Protein: AROC_ROSS1
Sequence: MPGNTFGQVFRLTTWGESHGPAVGCVVDGCPAGIEISEAFIQRELDRRRVGQSRVTSARQEPDQVQILSGVFEGRSTGAPISMLVFNTDAKPGHYDTIKHLYRPGHADYTWDAKYGFRDWRGGGRSSARETIGRVAGGAIAKLLLARYGISVIAWTSQLGDLKAEVIDESEIERNIMRCPDARVAALMVERVEQARRSLDSLGGVVEVRARGVPPGLGEPVFDKLQADIGKAMFSIPAIKGVEFGEGFGVAYMTGSTHNDPFVRRDDGTIGTASNHHGGILGGISTGEEIVLRIAAKPPASIARPQHTVDRAGNPAAIEIHGRHDPTVLPRLVPIAEAMLALVLADHLLRQRLARVDA
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: NACA_CAEBR
Sequence: MTGSTETRHNEKDVKEPQVDSDADSDNEAIEHQLTEEQRRVAEAAGLGDHIDKQAKQSRSEKKARKLFSKLGLKQVTGVSRVCIRKSKNILFVINKPDVFKSPGSDTYIIFGEAKIEDLTQHAQMSAIENMKPTREAPQLKTVEEDDNEDVEEDSTGIEEKDIELVISQANTTRNKAIRALKDADNDIVNAIMSLTM
What is the function of this protein?
May promote appropriate targeting of ribosome-nascent polypeptide complexes.
What are the official names of this protein?
Nascent polypeptide-associated complex subunit alpha, NAC-alpha, Alpha-NAC.
What is the protein family that this protein belongs to?
Belongs to the NAC-alpha family.
Protein: SYFB_MYCLE
Sequence: MRVPYSWLCEVVTVGAPDWDVSASDLKQTLVRIGHEIEEMITVGPVDGPLTVGRVTDIEELTGFKKPIRACVVDVGDGQQHEIICGATNFVVGDLVVVAFPGTTLPDGFAIAACETYGRHSAGMICSAAELRLSTDHSGILVLPPGTALPGADGADVLGLDDVVFRLAITPDRGYCMSVRGLAREIACAYDLAFVDPASDQAVPPLPVGGQAWPVTVQPETGVRRCALRPVTGIDFAAVSPWWLQRRLLLSGIRAISPAVDVTNYVMLELGHPLHAHDRNRITGGFTVRFARPGETIVTIDGIERQLDPVDVLIVDNVTTAAIGGVMGAASTEVRSDSTDVLLEAAVWDPARVSHTQRRLHLPSEAARRYERAVDPAISVAALDRCAMLLADIAGGTVSETLTDWRGSPPRADWSLPPIRIAVDLPDRIAGVVYNQGATTKRLTQIGAVVVDTVSSEGHTLTVTPPSWRPDLLQPSDLVEEVLRLEGLEVIRSVRPLAPAGRGLTAVQKRYRAIGKVLAQSGYVEILPTPFLPADVFDLWGLPADDPRRTTTRVLNPLESNRPQLATTLLPALLEALVSNVSRGIIDVALFAIAQVVEPTEWTGGIGSIPVDRRLTDAEIALLDASLPRQPQHVAAVLAGLREPRGPWGPGRLAEASDAFEAVRIIARVSGVDVFFRAVQYLPWHPGRCAEVFVGETPIGHAGQLHPAVIERAGLPKGICAIELDLAAMPIVEGLPAPQVSPFPAVLQDVSLVVSTQVPAQEVQDAIRDGAGELLEDIQLFDVFTGSQIGEDCKSLTFALRFRAPDRTLTEDDASAARDAAVRHAAERVGATLRT
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FSHB_TRIVU
Sequence: MKTAQFYVLFFCWKAIWCNGCMLTNITISVEREECEFCISINTTWCSGYCHTRDLVYKDPIRPNVQKTCTFKEFVYETVNLPGCAKQADSLYSYPVATACHCGSCDTDSTDCTVRGLGPSYCSFNERKE
What is the function of this protein?
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer.  Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways.  Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
What are the official names of this protein?
Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain.
What is the protein family that this protein belongs to?
Belongs to the glycoprotein hormones subunit beta family.
What are the subcellular locations of this protein?
Secreted. Note=Efficient secretion requires dimerization with CGA.
Protein: FUM1_LEIMA
Sequence: MLRRLAPLLAEFNFVPLVSKVSHKETKYRLLTKDYVSVVQPGAGLPEMLRVDPAALTLLSSTAFDDVEHLLRSSHLMSLRKIFDDPEASDNDKFVALQLLKNANISSARLLPGCQDTGTAIIAGYRGDQVFVPGNDEEALSRGVYDIFQKRNFRYSQNVPLSMYDEKNTGTNLPAQIDLYASKGMEYSFMFVAKGGGSANKSFLLQETKSVLNPKSLRNFLKEKLAMFGTSACPPYHVAVVIGGTSAEMTMKVLKYASCHYYDDLITKPDMKTGYTFRDLELEEEVLKVCQNIGMGAQFGGKYYAHDVRVIRMPRHGASCPIGIGVSCSADRQALGKINKDGVWLEELEMEPSQYLPDLKEDELLKTPAVMVNLNRPMPEVLQELSKHPVRTRLSLTGTIIVARDSAHARMREMLEAGKPLPQYMKEHPVYYAGPAKQPDGLPSGSFGPTTAGRMDPFVDLFQSHGGSMVMLAKGNRSKQVTKACHKYGGFYLGSIGGPAAVLAQNAIKKVECLDMKDLGMEAVWRIEVENFPAFIVVDDKGNDFFEQL
What is the function of this protein?
Catalyzes the reversible hydration of fumarate to (S)-malate (PubMed:22569531, PubMed:30645090).  Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (Probable).
What are the official names of this protein?
Fumarate hydratase 1, mitochondrial, Fumarase 1, LmFH-1.
What is the protein family that this protein belongs to?
Belongs to the class-I fumarase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SCP_MIZYE
Sequence: TDYLVSKWKIWYKSLDVNHDGIISIENVEESRNKFTDLHKLVGDKSTGVKVDMQKWWDTYIFLTPGAEISETQFVENLGNSFKKDKAFLATMTACFNMIFDVIDTDKDRSIDLNEFIYAFAAFGHENESVVRTAFALLKPDDDNTVPLRTVVDAWISFVTCEDASKTDVIKSAFES
What is the function of this protein?
Like parvalbumins, SCPs seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.
What are the official names of this protein?
Sarcoplasmic calcium-binding protein, SCP.
Protein: PAO1_VESOR
Sequence: FNPCPYSDDTVKMIILTEQNKKQDFYTLDTIGEHNQFNKLTAKSQVVFIVWQTGIGDAITARAGYIFLLDSGLAMLVDKYQMAPVASDIKLCNAGCYCKPTYVISVKKAIQFAWEHKCVGIRCSDPGVPTDGLSGRPHYGETLHKVRSYNGK
What is the function of this protein?
Neurotoxin of presynaptic effect which degrades lysophospholipids.
What are the official names of this protein?
Orientotoxin-1, Lysophospholipase, Orientotoxin I.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRE_ECO45
Sequence: MKPYQRQFIEFALSKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLGRFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDLDLPYCFNRKEAKDHGEGGNLVGSALQGRIMLVDDVITAGTAIRESMEIIQANGATLAGVLISLDRQERGRGEISAIQEVERDYNCKVISIITLKDLIAYLEEKPEMAEHLAAVKAYREEFGV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: NUOK_BURO0
Sequence: MLTLAHYLVLGAILFAIAIVGIFLNRRNVIIILMSIELMLLAVNTNFVAFSHYLGDVHGQIFVFFVLTVAAAEAAIGLAILVTLFRKLDTINVEDLDQLKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
Protein: FOLD_STRPZ
Sequence: MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKEGAIVIDVGMNRDDNGKLIGDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: GMT1_YEAS7
Sequence: MSELKTGHAGHNPWASVANSGPISILSYCGSSILMTVTNKFVVNLKDFNMNFVMLFVQSLVCTITLIILRILGYAKFRSLNKTDAKNWFPISFLLVLMIYTSSKALQYLAVPIYTIFKNLTIILIAYGEVLFFGGSVTSMELSSFLLMVLSSVVATWGDQQAVAAKAASLAEGAAGAVASFNPGYFWMFTNCITSALFVLIMRKRIKLTNFKDFDTMFYNNVLALPILLLFSFCVEDWSSVNLTNNFSNDSLTAMIISGVASVGISYCSGWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPRNFLSILSIFIGFLSGIIYAVAKQKKQQAQPLRK
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.  Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins.  Involved in vanadate sensitivity (By similarity).
What are the official names of this protein?
GDP-mannose transporter 1, GMT 1, Low dye-binding protein 3, Morphogenesis checkpoint-dependent protein 3, Vanadate resistance glycosylation protein 4.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Recycles between the Golgi apparatus and the endoplasmic reticulum.
Protein: DHTK1_CAEEL
Sequence: MMLRSAGGSIRRAITQRQNQHRFYRPGHGVFGHLPDPPKRVFENQGGLTPENAQRVHLINAFRRYGYLEADLDPLGLRKVESVAELDPAIYGLSLDENVKGNFSLHDLAEQLRHIYCGPTAIEFMHINNWEERQWISQNFENCIAEELRKEELLRIGDLMLKCENFDKFLSTKFPTLKRYGAEGAESMFAFFSELFEGAAEKQVEEIIIGIAHRGRLNLLTQLMDFPPVHMFRKIKGRAEFPESADAAGDVLSHLVSSFDYKGSEGNVHVTMLPNPSHLEAVNPVAMGKARARAWSMNKGDYSPDERSARAGDSVLNVLVHGDGAFTGQGVVWESIALSQAPHFRLGGTVHLVTNNQIAFTAESSVGRSSTHCTDIAKAFEYPVIHVNGDHPEEVVKATRLALAYRERFRKDVFINLVCFRRWGHNELDDPTFTSPVMYKEVEARESVPRLFLDRLVEEGFTTEEAVKEQLQKHTEQLNNELKKVDSTVPIDISHRGRWEGFKQAPKAIESWDTGVATDLLRFIGAGSVKVPEDFDTHKHLYKMHIDSRMQKMQTGEGIDWATAEAMAFGSILLEGNDVRISGQDVGRGTFCHRHAMMVDQSTDHIHIPLNELVEEQKNQLEVANNLLSEEAILGFEWGFSSENPRRLCIWEAQFGDFFNGAQIIIDTFLASAESKWLTSSGLTMLLPHGFDGAGPEHSSCRMERFLQLCDSREDQTPVDGENVNMRVANPTTSAQYFHLLRRQVVPNYRKPLIVVGPKILLRHPKAASTINEFGPGTTYQNVISEEHATSSQKIKKVIFVSGKHWINVEKARDERGLKDSVAIVRVEMLCPFPVVDLQAVLKKYPGAQDFVWSQEEPRNAGAWSFVRPRFENALGVRLKFAGRPELAWTATAIGEHHTKEAEEVINQTFA
What is the function of this protein?
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
What are the official names of this protein?
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: HEM3_CLONN
Sequence: MKIVVGSRGSKLALTQTNWVIDKIKQKYPQIQFEVKIISTKGDRIQHIALDKIGDKGLFVKEIEEQLISGDIDMAVHSMKDMSTEMPEELKFSYVPKREDYRDVLILNKKYNSIDELPMNAKIGTGSKRRKYQLLQYRDDLNIVPIRGNVETRINKIEMENLHGVVLASAGIKRLNIQEKLDYNIFYLNEDIMLPSPAQGILALEIRKDREDLEEILKSIEDKNSSIQAVAERAFLKGVNGGCHVPIGAICNINKDNVELTGLLGKEDGSKIIRKSLGGKIEDAEKIGYELAEIVLKEIN
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: Y4313_ANADE
Sequence: MALLLLEPVGGIAGDMFLAAAIDLGVDPAALARALESLGVPGWRLAVTRKAEHGIQGTHVDVVVEGEQPASRGLAEILALVAASGLPPRAREAARGIFERIGEAEARVHGVPVSEVHFHEVGAVDSIVDVCGAAVALDLLGWPEVRAAPPELGRGLVRTAHGTMPVPPPAVLELLKGKPVRPGGPPGEAVTPTGAALLAVLAEVGPLPAHVPLRVGYGVGTRAWPDRPNVLRATLAEPAPAAGAGGPGPETLWVLEANLDDCPGQLVARAIEAALEAGALDAWAAPLTMKKGRPGVLLGALCDEARRAAVTGALFAETTTLGVRRHAVEREALERAFEPVETGYGTVRVKVARLGGRELGAHPEYDDCAARARAAGVAVREVMAAALAAYRSRRP
What are the official names of this protein?
Putative nickel insertion protein.
What is the protein family that this protein belongs to?
Belongs to the LarC family.
Protein: RRT14_YEAST
Sequence: MSSSLSQTSKYQATSVVNGLLSNLLPGVPKIRANNGKTSVNNGSKAQLIDRNLKKRVQLQNRDVHKIKKKCKLVKKKKVKKHKLDKEQLEQLAKHQVLKKHQHEGTLTDHERKYLNKLIKRNSQNLRSWDLEEEVRDELEDIQQSILKDTVSTANTDRSKRRRFKRKQFKEDIKESDFVKDHRYPGLTPGLAPVGLSDEEDSSEED
What is the function of this protein?
Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription protein 14.
What is the protein family that this protein belongs to?
Belongs to the RRT14 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: Y1543_ALKCK
Sequence: MSKKQFYLVREDMLTDAMQRTLEAKALLSAGKVRKINEAVHRVGLSRSAFYKYKDGIFPFHAIAKERIMTFSINLADRSGTLSQLLNIVADTGANILTINQTIPLQGRANITLSVDTAPIEIDINELFERMEALESVERVELVGSGS
What are the official names of this protein?
UPF0735 ACT domain-containing protein ABC1543.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: HCP_SYNFM
Sequence: MFCYQCEQTAKGEGCTKIGVCGKQPEVADLQDLLLYALKGLALHAVEGAKVGVNDHETNVFTCEALFSTLTNVNFDPARFQVLIPRVVEYREKLKAKVKAAGGKVDFADPAATFTPAKTLEGLVAQGANVGLKSEPELPPDIVSLKHTLLFGLKGISAYADHANILGQHDDAVYAFIYEALAATLRKDIELGDWLKLVLKCGEMNLRTMELLDAANTGVYGHPVPTSVPLGPKQGKAILVSGHDLKDLEELLKQTEGKGINIYTHGEMLPTHGYPGLKKYAHFYGHYGTAWQNQQKEFSKFPGAILMTTNCIQKPQQAYTGNIFTTGLVGWPDVPHVTNRDFSPVIERALALPGFPETVNGKSVMVGFGRNTILGVADKVIEAVKNKNIRHFFLVAGCDGAKPGRNYYTEFVEKVPKDCVVLTLACGKFRFFDKDLGTIGGLPRLMDVGQCNDAYSAIQVAVALAKAFNCGVNDLPLSLVLSWYEQKAVAILLTLLYLGIRNIRLGPSLPAFVSGNVLDVLVKNFDIKPITTPDEDLKAILG
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_METS5
Sequence: MKMVVMVRTDINMGKGKIAAQVAHAAVSLVLDCMSRSSWRDWLDSWLHEGQPKVVVKVSSLEDLLSRVDKARSQGLPTTVISDAGRTQVEPGTVTCAGIGPGPDDLIDKITGDLKLL
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LENG8_DANRE
Sequence: MAANAAQQAPTQNWPYGNNSSGEGPVHENPEWEKARQALASISKSQNSTKPSTNQTTQQAGQYQAAVTDSSAMQQQQYYQQWYQQNQQQYAGYPYPYNYYYPMPPYGGPYPPGQYGVPGGYQTPTTPTGQAPSMPTMEDQSSNYPPQPPPPATPQPPPQSPTSSDQPPPPPPPPIPPQPNAQYPRPPSQTPYSPNGVLPYSPTDSNPMMRGYNPGQIRPGYQGYQTPVYQPHQQQAPAPGLYGGAGRVDAKKPNNSNMNKGGQQLWQRMKQAPGTGAVKFNIPKRPYVMSNQNFPPGEQGPGLAPPTATNPSSGSTSATSSASTGGAQTRPQDWPQAMKEYVQRCFTACESEEDKDRTEKMLKDLLQSRLQDGSAYTIDWNREPLPDLKPKQSRWEVMPQLSQENSIGRGGATRGRGGARLGNYRNVFSQRSPSSSSSGSSRSSSRSPSPHSRHRDRSRHHRSDSGSQSDGSMSSDLRLSLTRRQQKGGRGRGAERERGRGAAGERGRGRGKANRGRRNMEDLASGVGKKRKGGNAGLDFHDPNREAKKQSRAARFHTKLRTEPLVLNINVFDLPNGTQEGLSWDDCPIVGTCQDITKNYLRLTCAPDPSTVRPVPVLRKSLIAVKAHWKSNQDYVYACEQMKSIRQDLTVQGVRTDFTVEVYETHARIALEKGDHEEFNQCQTQLKALYKDCPSDNVGEFTAYRLIYYIFTKNSGDLTTELVYLTTELRADPCVAHALELRTAWALGNFHRFFRLYQKAPRMAAYLIDKFVERERNIALRAILKSFRPSVSVEYVQSSLAFPDLDTCLAFLTGLGISFTPSDPSKIDCKVSSASLTTS
What are the official names of this protein?
Leukocyte receptor cluster member 8 homolog.
Protein: DUT_HELHP
Sequence: MMKHMHIKIKKLHSHAVIPSYQTPQAAGFDLHAVEDSLIKARDRGLVGTGLAFEIESGFEVQVRPRSGLALHNGVSVLNTPGTIDSDYRGEIKVILINHSNEDFHIHRGDRIAQAVVSEVTQAVFTEVQELGQSVRGERGFGSSGVARKGHYQGKPLA
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: MCC20_ARATH
Sequence: MGKQINNTFTWVIKNLSTLQGLEVRSKIFVVGGCKWRLIAYPEVNDADGYLSLSVYLGVPDCCESLPSGWKRHAKFSLTIVNQLSEGLSQVQETQAWFDENAPGWGFPPMLNLKDVSDKYGGFLVNDEVMVAVAVDVIEVVGSLDAPEMSESMDIKGFKVLPSQVKSVNRLFESHPDIASKFSIKNQSLKTAYMNVLLCLAETLHQSPMEISEDDLSDAKTTLAYMKSVGFKLDWLEKKLDELFEKKKEEADKIRMQNIEEELKDLRQKCSSLEALLKKEKTGVLAAKAPFLFFNNVNDDDLKWILRAVMYTLIMMLFISI
What are the official names of this protein?
MATH domain and coiled-coil domain-containing protein At3g58260, RTM3-like protein At3g58260.
Protein: PRSN_PIEBR
Sequence: MSNNPPYMTNGIQAAVVEWIRALDLEIISLLLSRAWPLALLTTTELRWRPTVLTDTDNVVRLDRRQRLVRWDRRPPNEIFLEGFVPIVTREDPDWEETDLYGFAKNNHPSIFVSTTKTQRNKKKYVWTPRNANRGIVYQYEIYAPGGVDVNDSFSDASPWPNQMEVAFPGGIQNIYIRSARELHNGRVQRIWINPNFLDPGDLEPIVSSSRTLQVIWRVNHPDGGNKDGRSERSTSSYDDLMYGGTGNVQEDTFGDESNNPKPIADGEFMIESIKDKNSFLDLSKNVNGGIIHSNVYSGGDNQIWVFSYDDNKKAYKIKSYQNSSLYLSWDSNASSKEIILRGYTNSGSNNQYWQIEQTGKNYRLRNLLNLNMIITAQDKSSAFGGKEVIVNTEISNSNTKSSQEWNIIPFDFRPIMDGDYNIFNLDLPNQVVDFSNQPDLLVHGHEFCDNENQTWHFTYNSTYHAYKIWSGRKSNLLLTWDSNATSKEMVVRAYTESRSKNQYWRIEQTGSKSYKLRNLENSNMILGLTNVSTSYGGLNLMVQDDSNGNSNLHSDWDIKPIIYQYVPDGDYNIFNDNFPNIAVDYTNQEGALVHGHNFCSNNNQKWSFVYDGKKKAYKIKSGVNSKLWLTWDSNASSKEMVLRAYTESGNWNQYWRLYQANDGSYIIRNLKEFKMLIALTNIDTPYGGKQLIVTDTKESGNHWYLKKLGEVPLPNRKFRIATKLNYKKVIDSSTAYNLIITHDLNFASSIWELVYDSNKKAYNIYSADINNLGWVYQNKNFFVKLDNIDGPDHGDLRYFWTIEYSMQTGCYLIRSLYDPAHAVGYTDKDSVITDTSTYSDNQLFHFILM
What is the function of this protein?
ADP-ribosylates double-stranded DNA by targeting the N2 amino group of dG residues.  Induces apoptosis in a range of human cell lines (PubMed:10971585) (By similarity).  May play a role in destroying cells during pupation and/or defense against parasites (By similarity).
What are the official names of this protein?
Pierisin, NAD--DNA ADP-ribosyltransferase, Pierisin-2, Pierisin-B.
What is the protein family that this protein belongs to?
Belongs to the pierisin ADP-ribosyltransferase family.
Protein: VGP_EBOEC
Sequence: MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVNDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETIYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKNLTRKIRSEELSFTVVSNGAKNISGQSPARTSSDPGTNTTTEDHKIMASENSSAMVQVHSQGREAAVSHLTTLATISTSPQSLTTKPGPDNSTHNTPVYKLDISEATQVEQHHRRTDNDSTASDTPSATTAAGPPKAENTNTSKSTDFLDPATTTSPQNHSETAGNNNTHHQDTGEESASSGKLGLITNTIAGVAGLITGGRRTRREAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYTEGLMHNQNGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTCHILGPDCCIEPHDWTKNITDKIDQIIHDFVDKTLPDQGDNDNWWTGWRQWIPAGIGVTGVIIAVIALFCICKFVF
What is the function of this protein?
Acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in GP2, releasing the fusion hydrophobic peptide.
What are the official names of this protein?
Envelope glycoprotein, GP1,2, GP.
What is the protein family that this protein belongs to?
Belongs to the filoviruses glycoprotein family.
What are the subcellular locations of this protein?
[GP2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Note=In the cell, localizes to the plasma membrane lipid rafts, which probably represent the assembly and budding site. SUBCELLULAR LOCATION: [GP1]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=GP1 is not anchored to the viral envelope, but forms a disulfid-linked complex with the extravirion surface GP2. In the cell, both GP1 and GP2 localize to the plasma membrane lipid rafts, which probably represent the assembly and budding site. GP1 can also be shed after proteolytic processing. SUBCELLULAR LOCATION: [Shed GP]: Secreted. Note=GP2-delta bound to GP1 (GP1,2- delta) is produced by proteolytic cleavage of GP1,2 by host ADAM17 and shed by the virus.
Protein: SYE1_ACIF5
Sequence: MSVRTRFAPSPTGYLHIGGVRTALYSWLHARRQGGHFILRIEDTDVERSTPEATVAILEGMAWLGLDWDEGPFYQMRRMDRYREVLAQMLAAGTAYHCYCSREEVEAMREDQRQRGEKPRYDGRCRERTTVPEGVAPVIRFRSPDDGETVVEDLIHGTVRFQNSEMDDLIIARSDGTPTYNFCVVVDDWDMGITHVIRGDDHLNNTPRQMQILQALGARVPVYAHVPMILGPDKQKLSKRHGAVSVLEYREQGFLPDALLNFLVRLGWSHGDQEIFTREEMVEFFRIDAVNKAASAFNPEKLLWINAQHMQRLTPEGLAQHLLPYLNAVGVTEPLLASGPELPAVVALLQERSKTLVEMAAAAEMFYVAPVAGEPKDVEKHLHGQSALLATMTQALGALPNWEAAAIHSVIQELAVTHADGKMGKVAQPLRVAVAGRAVSPPIDATLALLGKEETLARLRRAAAWI
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 1, Glutamyl-tRNA synthetase 1, GluRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3786_XANP2
Sequence: MKITWFGHAAFRLDFADKAVLIDPFFTGNPSFNSTVEEAARGVTHILLTHGHSDHVGDTVSLVEDAADASRTLPVVANPEICAYLAAKGAGNAGQMMNTGGSLDCGGFTVTMVRADHSSGGPGSPSEYLGNPTGLIIRAPGEPTVWHMGDTDIYSDMALMCEIHRPKVVFIPIGDRFTMGPAVAALAVKRFLPGVEVVVPCHYGSFPILVQDASFFAQALADHPVKVVVPGPGGSFDANITPA
What are the official names of this protein?
UPF0173 metal-dependent hydrolase Xaut_3786.
What is the protein family that this protein belongs to?
Belongs to the UPF0173 family.
Protein: FAA22_MYCTO
Sequence: MRNGNLAGLLAEQASEAGWYDRPAFYAADVVTHGQIHDGAARLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANPELHRDDHALAARNTEPALVVTSDALRDRFQPSRVAEAAELMSEAARVAPGGYEPMGGDALAYATYTSGTTGPPKAAIHRHADPLTFVDAMCRKALRLTPEDTGLCSARMYFAYGLGNSVWFPLATGGSAVINSAPVTPEAAAILSARFGPSVLYGVPNFFARVIDSCSPDSFRSLRCVVSAGEALELGLAERLMEFFGGIPILDGIGSTEVGQTFVSNRVDEWRLGTLGRVLPPYEIRVVAPDGTTAGPGVEGDLWVRGPAIAKGYWNRPDSPVANEGWLDTRDRVCIDSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGATIDGSVMRDLHRGLLNRLSAFKVPHRFAVVDRLPRTPNGKLVRGALRKQSPTKPIWELSLTEPGSGVRAQRDDLSASNMTIAGGNDGGATLRERLVALRQERQRLVVDAVCAEAAKMLGEPDPWSVDQDLAFSELGFDSQMTVTLCKRLAAVTGLRLPETVGWDYGSISGLAQYLEAELAGGHGRLKSAGPVNSGATGLWAIEEQLNKVEELVAVIADGEKQRVADRLRALLGTIAGSEAGLGKLIQAASTPDEIFQLIDSELGK
What is the function of this protein?
Catalyzes the adenylation of p-hydroxybenzoic acid (pHBA) to form p-hydroxybenzoic acid-AMP (pHBA-AMP), which is converted directly to p-hydroxybenzoyl-S-FadD22 (pHBA-S-FAdD22) thioester intermediate in a CoA-independent manner by attack of the phosphopantetheine thiol of FadD22.  Usually, this intermediate primes the biosynthesis of the phenolphthiocerol (PPOL) by presenting the pHBA starter unit for elongation by Pks15/1, but M. tuberculosis lacks Pks15/1 due to a natural frameshift and thus is unable to produce PPOL.
What are the official names of this protein?
p-hydroxybenzoic acid--AMP ligase FadD22, p-HB--AMP ligase FadD22, p-hydroxybenzoic acid-AMP synthetase, p-HB-AMP synthetase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: RL44_BRUMA
Sequence: MVNVPKTRRTFCDGKCRRHTMHKVTQYKKGKESRLAQGRRRYDSKQKGFGGQTKPIFRKKAKTTKKIVLRMECTECKHRKQLPIKRCKHFELGGQKKTRGQVIQF
What are the official names of this protein?
60S ribosomal protein L44.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL42 family.