PharMolix/UniProtQA huggingface dataset:
Protein: IF1_COXBR
Sequence: MAKEESIEMQGTVVDSLPNTTFRVKLENGHVVTAHISGRMRKHYIRILTGDAVTVELTPYDLTRGRIVYREAGKKPPTSKAEE
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHI1_ARTBC
Sequence: MALPKTIMAFIAFISFLVSTTFAVDVFSTTNVVTYWGQGHDQKRLSHYCQQAEHDIIVIGFVNVFPDQGKGGWPGTNFGNQCFMGTYITPEGEETELLSSCHKIIEDIPICKAAGKTIMLSLGGQAVDGSKTYSVKTRQSAVYFADFLWRAFGPVSPEWDGPRPFGDNVIDGFDFDIEANGGANYEYMVERLRSNFATDSSRQYYLSAAPQCVLPDGNLGNVISSSAFDFIFVQFYNTPSCSAFNWAQNPSKSGFTFDSWVQFIRKGASRNAKLFIGLVGDHTRVSPHGEYTKDDSNYLALPDADKLIKAYMNKYRANFGGVMIWDALTSDENKLVTGTYSSNIKRLLLNNDPSRPTTTSKTMSSTKTSMSTTTSKYTVTTSTISSTSKISSSTWSMPTMTTSTRTTSSTATRSSTIVTPSTSPNPTTSTSTTSGHQNTTATTTEIETQTSKTFITTTSIWSSGTGIGTCTGIPTITTTPRYPNATFTSDTTGSPTMSDTTITLSVTSSMHQISDTTTTIPTFSTTPIQTSDISLSMPSGTTTSKHQSSGITIPGPPHMSTTIVPASPTKPGHSTTTAIVTTTFTSVCPTGITTVTTTYTTIYCPEATPMPTAGNPPPPPGMEWTTIVTTCTKCASTSAIMTVTYPVTVPSEPMTPTQVPGTLPPPGAPGTGSGIPPPKTPSNEPGSPGTLTGIFPPKPTMSVPPEMGGNGGDRTPVYTGGAGVVSPSFSVVVIVLGSIVYHIMQ
What is the function of this protein?
GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods).  Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.
What are the official names of this protein?
Probable endochitinase ARB_07371.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor. Secreted, cell wall.
Protein: LIS1B_SALSA
Sequence: MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEITLGGPVAQKRDPKEWIPRPPERYALSGHRSPVTRVIFHPVFSVMVTSSEDATIKVWDYEAGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVKTFTGHREWVRMVRPNQDGSLIASCSNDQTVRVWVATSKECKAELREHEHVVECIAWAPDTAHPTILEATSSESKKNGKSGPFLLSGSRDKTIKMWDISTGMCLMTLVGHDNWVRGVLVHPGGRFIVSCADDKTLRIWDYKNKRCMKTLCAHEHFVTSLDMHQTAPYVVTGSVDQTVKVWECR
What is the function of this protein?
Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation.  Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity).  Positively regulates the activity of the minus-end directed microtubule motor protein dynein.  May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end.  Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome.  May be required for proliferation of neuronal precursors and neuronal migration.
What are the official names of this protein?
Lissencephaly-1 homolog B.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LIS1/nudF family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the plus end of microtubules and to the centrosome.
Protein: GUAC_MYCMS
Sequence: MKIFDYDDVQLIPEMCIVNSRKECETTATLGKHTFKLPVVPANMATIINEELAEKLARNDYFYIMHRFNVDQLKFIKNMKDKNLITSISLGVKPDEYKLVDQMVQQNLIPDYITIDIAHGHALSVKNMISYIREKMKDQVFIIAGNVTTPKAVRDLELWGADATKIEIGPGKVCITKLKTGFGTGGWQLSALKYCAKTASKPIIADGGLRVHGDIAKSIRMGASFCMIVSLFAAHLESPGKEVEINNCIYKEYYGSASEYNKSEKRYVEGKKELIKIRGSIFDTLKEMTEDLQSSISYAGGKDLQAIKRVDYVLLGDYKD
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: ANKH_MOUSE
Sequence: MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRAKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYRNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLANTSNTVTSAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVIPLRIFSFFPVPVTVRAHLTGWLMTLKKTFVLAPSSVLRIIVLITSLVVLPYLGVHGATLGVGSLLAGFVGESTMVALAACYVYRKQKKKMENESATEGEDSAMTDMPPTEEVTDIVEMREENE
What is the function of this protein?
Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter.
What are the official names of this protein?
Progressive ankylosis protein, Fn54 protein.
What is the protein family that this protein belongs to?
Belongs to the ANKH family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RNPA_PORG3
Sequence: MTSPATFGLSKSERLYLRDEINTVFGEGKAFVVYPLRVVYRLGSEHRAAYSSMLVSVAKKRFRRAVKRNRVKRLVREAYRLNKHLLNDVLQERQIYATIAFMVVSDELPDFRTVERAMQKSLIRIAGNVPSSALKNE
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: NU3M_EQUAS
Sequence: MNLMLTLLTNTLLASLLVLIAFWLPQLNIYAEKTSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTTNLNTMLIMALILISLLAISLAYEWTQKGLEWTE
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 3, NADH dehydrogenase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RPOA_ANTAG
Sequence: MIQNEIPIPAEALQWKCIESKIDSERLHYGRFAISPLRPGQANTVGIAIRRALLGEIEGTCITYVKFEKVTHEYSTIMGIQESVHDILINLKEIVLKSNSYKTQEASISILGPKRVTAEDIVLPSSVEVIDATQHIATITKAVYFNIKLGIRKDRGYRIENPVKYEDGNFAVNAAFTPIRNANYSVHSFENEKEKQEILFIEVWTNGSLTPKEALREASQSLINLFIPLLHEKKERENRKLENKDEYNVLRSCFSLTNIGEVRKEISFKHIFIDQLELPARAYNGLKKVDVHTISDLLNYSQEDLMKIKNFGKKSIQQVVEALQKHFAIHLPKNKFSIND
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LIPB_ECOSE
Sequence: MYQDKILVRQLGLQPYEPISQAMHEFTDTRDDSTLDEIWLVEHYPVFTQGQAGKAEHILMPGDIPVIQSDRGGQVTYHGPGQQVMYVLLNLKRRKLGVRELVTLLEQTVVNTLAELGIEAHPRADAPGVYVGEKKICSLGLRIRRGCSFHGLALNVNMDLSPFLRINPCGYAGMEMAKISQWKPEATTNNIAPRLLENILALLNNPDFEYITA
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARLY_MYCS2
Sequence: MSTNEGSLWGGRFADGPSDALAALSKSTHFDWALAPYDIKASKAHARVLHRAGLLTDEQRDGLLAGLDSLGSDVADGSFEPLPTDEDVHGALERGLIDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVADGCLEVVNALAVQAAAHPTAIMPGKTHLQAAQPILLAHHLLAHAHPLLRDVDRLADFDDRTAVSPYGSGALAGSSLGLDPDAIAEDLGFASAADNSVDATASRDFAAEAAFVFAQIGVDLSRLAEDIILWSSTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAMAGLVGTLTFDEERMAELAPAGYTLATDIAEWLVRQGVPFRIAHEAAGAAVKVAEGRGVGLDALTDDEFASINPALTPDVREVLTVEGSVNARNARGGTAPTQVAKQLGVVRKAMEELRIRLS
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BTUD_ECOHS
Sequence: MSIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFAMPVWHYLTLHQHDKTRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVRLAAVVLQITPQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAHRAWLLKGGKMLASGRREEVLTPPNLAQAYGMNFRRLDIEGHRMLISTI
What is the function of this protein?
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Vitamin B12 import ATP-binding protein BtuD, Vitamin B12-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: PTH_MYCAP
Sequence: MKLIVGLGNPGNEYRFTRHNAGFLAIDKICEKLNISLNKEKFNGEFAVSDGFILAKPLTYMNKSGDFVYSIASFYKINPSDIIVIYDDLSFSIGQAAIKIGGSSAGHKGIERLMSKFSSNDFKRIRVGIGVNSGTTIKDYVLSLFTKDEMIVVEEVLEKVADAAISLVYNDVNFVMNKFNTDNKKRVI
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPA_ADICA
Sequence: MVINIQPDEIGSIIRKQIKGYVPEMKVVNIGTVLQVGDGIARIHGLDEVMAGELVEFEDGTVGIALNLESDNVGAVLMGDGLTIREGGSVRATGKIAQIPVSDSFLGRVVNALAQPIDGKGQIPASEFRLIESSAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQKGQNVICVYVAIGQKASSVAQVVDTFRERGALEYTIVVSETANSPATLQYLAPYTGAALAEYFMYRKQHTLIIYDDLSKQAQAYRQMSLLLKRPPGREAYPGDVFYLHSRLLERAAKLSTQLGEGSMTALPIVETQAGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFASDLDKTTQNQLARGQRLRELLKQSQSAPLAVEEQVATIYTGVNGYLDVLDVEQVKRFLVQLREYVATSKPSFGEIIRSTKVFTEQAEALLKEAIKESTELFLLQER
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: CDD_YEAST
Sequence: MKVGGIEDRQLEALKRAALKACELSYSPYSHFRVGCSILTNNDVIFTGANVENASYSNCICAERSAMIQVLMAGHRSGWKCMVICGDSEDQCVSPCGVCRQFINEFVVKDFPIVMLNSTGSRSKVMTMGELLPMAFGPSHLN
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, CDA, Cytidine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: FYB1_MOUSE
Sequence: MAKFNTGSNPTEEAATSSRPFKVAGQSSPSGIQSRKNLFDNQGNASPPAGPSSMPKFGTTKPPLAAKPTYEEKPEKEPKPPFLKPTGGSPRFGTQPNSVSRDPEVKVGFLKPVSPKPTSLTKEDSKPVVLRPPGNKLHNLNQESDLKTPGPKPGPAPPVPENELKPGFSKVAGAKSKFMPAAQDTDSKPRFPRHTFGQKPSLSTEDSQEENTSKNVPVQKGSPVQLGAKSKGAPFKPPKEDPEDKDHGAPSSPFPGVVLKPAASRGSPGLSKNFEEKKEDRKTDLAKNIFLNKLNQEEPARFPKAPSKLTAGTPWGQSQEKEGDKNSATPKQKALPPLSVLGPPPPKPNRPPNVDLTRFRKADSANSATKSQTPYSTTSLPPPPPTHPASQPPLPASHPAHPPVPSLPPRNIKPPLDLKHPINDENQDGVMHSDGTGNLEEEQESEGETYEDIDSSKERDKKREKEEKKRLELERKEQKEREKKEQELKKKFKLTGPIQVIHHAKACCDVKGGKNELSFKQGEDIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKRKKNSLNAVPPRLVEDDQDVYDDVAEQDAPNSHGQSGSGGMFPPPPTDDEIYDGIEEEDDDDGSVPQVDEKTNAWSWGILKMLKGKDDRKKSIREKPKVSESDNNEGSSLPSQHKQLDVGEEVYDDVDASDFPPPPAEMSQGMSVGRAKTEEKDPKKLKKQEKEEKDLRKKFKYDGEIRVLYSTKVASSLTSKKWGARDLQIKPGESLEVIQSTDDTKVLCRNEEGKYGYVLRSYLVDNDGEIYDDIADGCIYDND
What is the function of this protein?
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (PubMed:9207119, PubMed:10497204).  May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity).  Modulates the expression of IL2 (PubMed:9207119, PubMed:10497204).  Involved in platelet activation (PubMed:17003372).  Prevents the degradation of SKAP1 and SKAP2 (By similarity).  May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493).
What are the official names of this protein?
FYN-binding protein 1, Adhesion and degranulation promoting adaptor protein, ADAP, FYB-120/130, p120/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell junction. Note=Colocalizes with TMEM47 at cell- cell contacts in podocytes.
Protein: HYPDH_XENLA
Sequence: MRLLGRYLRLGSPRLCSRVWPTLPPSCSPHSTAAAAQAQGALSFSDGGVFKLKSSWEVARGLLIFRMCSFPSLVKHSEKMLSVSRRLLGRRLFEWGMKGSVYGQFVAGETLPEIRVCVDRLRQLGIHPMLAVPIEEDLGQAKSGERWYEQNESIMLDCVDLSAAGGDRPMMQLKITALMSAELCKLLSVHLSHPSNGPQLCPRSIVSIMEGKESAFSFLSEGENSHLRNSVRRLSRIAKHATANRVRVLVDAEYTYMNPALSLVTMAMMSQCNQSEPWIWNTYQCYLKDSFSLLSLDLDTARSLGLCFGVKLVRGAYMDKERKLSKQKGYADPIQHDWEATNRSYQRSLDKMLDLIGQNGQRHNLIVASHNEESVLHAVTRMAELGIDKGSGSVSFGQLLGMCDHVSLTLGQAGYLVYKSLPYGSVDSVLPYLIRRAQENQSVLQGIRKERDLLRRELKRRLFNQR
What is the function of this protein?
Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using a quinone as the terminal electron acceptor.  Can also use proline as a substrate but with a very much lower efficiency.  Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline.
What are the official names of this protein?
Hydroxyproline dehydrogenase, HYPDH, Probable proline dehydrogenase 2, Probable proline oxidase 2.
What is the protein family that this protein belongs to?
Belongs to the proline oxidase family.
Protein: MNMG_LAWIP
Sequence: MRTTFDCIVVGGGHAGCEASMALARLGQKVLLITGNVDRIGHLSCNPAVGGIAKGHIVREIDALGGMMGLWADKAGIQFRTLNRSKGPAVRATRAQVDRDLYMQAVKQDIFSQPNLSVWQDTVEAIIVKDGHTGGVKTALGQLFNSQYVILTTGTFLSGLMHIGQKNFSGGRLGDVGTSKLSSSLHSIGLHLGRLKTGTTPRLLKTSIDFTSMEMQLGDTPIPSFSFHGPKPSQPQVPCYITWTNEYTHDVIRSGMDRSPMFTGVITGTGARYCPSIEDKVARFADRDRHQIFVEPEGLTSQECYINGISTSLPLDIQLALIATIPGLENAHMVRPGYAIEYDYVDPMQLHPTLETKVLPGLWLAGQINGTSGYEEAAGQGLWAALNVFCKITRQEPFILGRDNAYLAVLVDDLVTQGTKEPYRMFTSRAEYRLLLREANADIRLTPLGRKIGLVGDYQWNLFQKKISDIDTLVNRLQNIRIKPDTLDPSIFLELGESIPNRAYTLEELLKRPSITFQTLRKIYSDLPITSEDVYLETETIIKYAGYLDRQEELVQRSAKLEHSYLPKEIDYTKVAGLSSEVIEKLQIVRPQTLGQAGRISGVTPAAITCLEIYLKKIHAFR
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYALP_MACFA
Sequence: MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPIIPNVPFLWAWNAPSEFCLGKFNEPLDMSLFTLMGSPRINVTGQGVTIFYVDRLGYYPYIDLTTGVTVHGGIPQKVSLQDHLDKSKQDILFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLPQATDKAKQEFEKAGKDFMLETIKLGRSLRPNHLWGYYLFPDCYNHHYRKPGYNGSCFDVEIKRNDDLSWLWNESTALYPSIYLNTQQSVVVATLYVRNRVREAIRVSKIPDAKNPLPVFVYARLVFTDQVLKFLSREELVSTLGETVALGASGIVIWGSLSITRSMKSCLLLDTYMETILNPYIINVTLAAKMCSQVLCQEQGVCIRKDWNSSDYLHLNPDNFDIRLEKGGKFTVHGKPTVEDLEEFSEKFYCSCYTNLSCKEKADVKDTDAVDVCIADGVCIDASLKPPVETEGSPPIFYNTSSSTVSTTMFIVNILFLIISSVASL
What is the function of this protein?
Involved in sperm-egg adhesion.  Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida.  The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation.  This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
What are the official names of this protein?
Hyaluronidase PH-20, Hyal-PH20, Hyaluronoglucosaminidase PH-20, Sperm adhesion molecule 1, Sperm surface protein PH-20.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 56 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: DNAJ_STRP1
Sequence: MNNTEYYDRLGVSKDASQDDIKKAYRKMSKKYHPDINKEAGAEQKYKDVQEAYETLSDSQKRAAYDQYGAAGAQGGFGGGAGGFGGFDGGGFGGFEDIFSSFFGGGGSRNPNAPRQGDDLQYRVNLSFEEAVFGVEKEVSYNREATCGTCLGSGAKPGTAPVTCRKCHGSGVMTIDTQTPLGMMRRQVTCDICHGSGKEIKEPCQTCHGTGHEKQAHKVSVKIPAGVETGQQIRLQGQGEAGFNGGPYGDLFVILNVLPSKQFERNGSTIYYNLDISFTQAALGDTVEIPTVHGDVEMAIPAGTQTGKTFRLKGKGAPKLRGGGQGDQHVTVNIVTPTKLNDAQREALQAFAEASGEKMLHPKKKGFFDKVKDALEDI
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP19_BPMU
Sequence: MSERSARQWPDFLSVVLLALLLWISLFCGWRALMFCCASVFSVALCVAADCLDALIMSCRVPEHFARFVWPLTWLGSLSGLGLAVMATSQLKTGPEHVIWALAGLLTFWLSFRFRARLFG
What are the official names of this protein?
Uncharacterized protein gp19, E19 protein, Gene product 19, gp19.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNAA_HERA2
Sequence: MDTKQIWFTTLGTLQNQILRYDYDTWLKTTALVSVANDLAVIGAPNVTTKQVIEDRFMSVLRRALGEVLGYQVNVRVIISSATPAPSEPVAVTPSEPSPTTEVAEPSFASFNQAAPMLNQLPLGDPNRSSVLNPRYTFSSFIVGTSNRLAHAACMAVAEHPAQAYNPLFLYGGVGLGKTHLLQAIGNYALDRNPEVNVLYVSSEKFTNDLINAIRRQQTEEFRIRYRNIDILLIDDIQFIAGKEGTQEEFFHTFNTLHGAGKQIVLSSDRPPKAILTLEERLRSRFEWGLIVDVQNPDLETRTAILRAKGETLQVPVSSEVIDFLAQRIQSNIRELEGCLNRVIAYANLNRTPVTVEVASAALADLLDTSRRKRVTADDIFREVSQHYGIDQRAIRGRGRSRNVVLPRQVVMYLLREETDASLVEIGELLGGRDHTTVMHGYNKITDDLTSDARLRNDITSLRQRLYGENAR
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALR_ACIET
Sequence: MPRPILATIHPAAVHHNLERARRAAPDARVWAVVKANAYGHGIERVFEGLRAADGFALLDLAEAERVRALGWRGPILLLEGVFEPRDLELCSRLGLWHAVHCDAQIDWLAAHKTQVPHRVFLKMNSGMNRLGFTPERYRSAWARLNALPQVDEISCMTHFSDADGPRGIAHQVQAFQTATRDLPGERCIANSAALLRHGGDAQVRLDWVRAGIVLYGSAPDHPERRAADWDLQPTMTLASRIIGVQQLQAGDTVGYGSRFTAQGPLGIGVVACGYADGYPRHCDTGTPVLVNGVRTRTIGRVSMDMLAVDLTPVPGAGLGAEVTLWGRAANGAVLPIDEVAQAGGTIGYELMCALAPRVPVVVQD
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: CCME_MARMS
Sequence: MHPVRKKRLLVITAIVLILSAAVGLVMYALQQNINLFFSPSQIAMGEAPLNVIIRAGGMVVKGSVKRNSDTLAVAFDVTDFQYKVTIEYRGILPDLFREGQGIVAQGKLNNDGVFEATEVLAKHDEKYMPPEITEALKNAQRSTGESAESVQSTY
What is the function of this protein?
Heme chaperone required for the biogenesis of c-type cytochromes.  Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
What are the official names of this protein?
Cytochrome c-type biogenesis protein CcmE, Cytochrome c maturation protein E, Heme chaperone CcmE.
What is the protein family that this protein belongs to?
Belongs to the CcmE/CycJ family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: SAA1_NEOVI
Sequence: MKLFTGLIFCSLVLGVSSQWYSFIGEAAQGAWDMYRAYSDMIEAKYKNSDKYFHARGNYDAAQRGPGGAWAAKVISDARERSQRITDLIKYGDSGHGVEDSKADQAANEWGRSGKDPNHFRPPGLPDKY
What is the function of this protein?
Major acute phase protein.
What are the official names of this protein?
Serum amyloid A-1 protein.
What is the protein family that this protein belongs to?
Belongs to the SAA family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRI_HALSA
Sequence: MSSDQHLQVSKIQAGTVIDHIPAGQALQVLQILGTNGASDDQITVGMNVTSERHHRKDIVKIEGRELSQDEVDVLSLIAPDATINIVRDYEVDEKRRVDRPDVVAGVLSCPNPNCITANDEPVRSGFDVLDDGMRCQYCEQIVSEDIPSLIDPE
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: MURD_SOLUE
Sequence: MKLQGVRALVVGMRKSGVASAEFLARRGAVVSATDLKPLDELPGVGELGIPFAVQTPAVFEGYDLIVPSPDVPYDLPPLEEARRHGVRVIGEVELAAPFLKGRTIGITGSNGKTTTTSLTGHILREAGVPVQVGGNIGLPVTAMVESSRDDGWNVLELSSFQLETIHEFRAHIGLALNVTQNHLDRHHTFENYAAIKGRLFETQQAGDYAVLNAEDPVCVAYAARTRATVQWFSSRKKVDPGATLCGNKLVLFGKLLMEAGEIPIRGRHNIENVLAAAIAASRAGVEHAAIAAAVRSFRAVEHRLEFVRKLNGVDFYNDSKATSVDATLKALDAFPGGLWVILGGKDKGLDYAALREPLTEKARAALLIGAAAGKIAEQIAGAVPLVDAKTLDGAVRHAFAHAAPGDTVLLAPACASFDQFKSYEHRGETFKQIVNGLEPKD
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.