Protein: PYVA_ASPV1
Sequence: MDPQQRLLLEVVFEAFEDAGISLEEMNGSRTSVLCGAFTNDYNAMLTKDLEYYPKYTVTGTGNAILANRISYAFNLKGMSLTIDTACSSSLVGFHLGAQAILNGDCEMAIIVGSALHFDPNIFITMTDLGMLSQEGRCRAFDAGGKGYARGEGICAVILRGQMQAEMHGDHIRALVRATGSNHDGMTQGITLPSSEAQEALIRRTYQSCGLDPADTQYVEAHGTGTARGDPLEMRAIGACFSSPRRSDPLYVGSVKSNIGHAEGASGLAGLIKASMALEKGQIPPNMHFKHPNPEIAFADWQIEVPTRVIDFPSNAQGTRRVSINSFGYGGSNAHVILESYDQLPHVQPTDPGAHRPYLVPLTSHTEKAGKLMVEKLGAYLDDRPSTLVVDLAHSLATRRTLHDERSFAVGASAADIRTQLSEGLPAWTKVRREPVRLGFVFTGQGAQWHAMGRQLLEQCPFFRHTLERADRILATLPDKPEWSIVTELTQPKETSRLGETRLSQPICTALQLAILDLLKSWGIVPQATVGHSSGEVAGAYAAGILTFENAMYAAYYRGLHMSSPRSSTSPGRDAIPGAMLAVGLGEAEAMAETESYRGRAVVAAVNSPSSVTLSGDADAIAEIKERLDAQKVFARRLQVQQAFHSHHMDPLAPAYEEALRNCPGFAATAPACRFFSSVTARVANPDTMGPQYWSANMTGTVRFSDALIGVLLDDLEDPNVDALVEIGPHPALKGPARQVMKSVNMDLPYFASLSRGVPDYEGILALAGQLFQLGYPVDLTAVNSDTYLADSDPPRQTHRAQRIPDLPLYAWDHSDRYWAETRLIKEHRLRPHHHPILGAKMPGSIEGHVRWRNYLRTRELPWLVDHMVDNKVTFPAAGYVTLAIEAALRMKDTVMAAQGVSLRNLSIKSALVLDESEMGSEVVVDIRPQTTSAKSRSDTWLEFTIFSYNGSLTCAEHCTGLISISTATTADGAPSRKPYRQHPQPQPGRMSTASFPAQSFYTHLRQLGLQYGEHFQLLTGTIESGAGFSSSMLTFEPAQYAAQPADRTVVHPTMLDAAFHTIFAALEGLSGRTLQTAFVPTFVHSLDIFPAMLSGMDAPRPLEARVASSAHFSGPRAAVSDVDMYRQGDGEALLSLAGLRLTSLSNGRAAHNRSLFFRTRWQPAFDQLAEDSPALQDQTLAGVLDLFLHQHPDTKILHFTPDINQTRQLVGCLVDQGSERRRFRSITPVATGGAFAEELERVQREQPGCLVTGEPEPEAYDLVIVSEAQEAHPLPFLRDGGYVISHGSAIDETNLTKRFQCADVEVWQRTRETRRDVRPLLLAMAPTPSRRTLDLASHIRAANPDRPVSCLGLQELLARMTGVEDVVVLASLDRDLLSGLDPQGELFFEATRALLIRPDVNVLWLLQDTTAPRHVDSLGSSMIVGLARTARSENPSSRIVTLDLPVDWSPAAVVPWLPQLLDPEVHEDEFHLRDQVLSIPRIENDDGLNSKVPGGVSSGPRPESFSAQRPMRLAIGQAGLLETLVWEDDVEILNEPLPDDEIEIEVKASALNFRDVAAAMGIIDDHRLGDECAGLVRRVGQQVDPAAFQPGDRVVALRPGRGAHRSVVRNPACHCFRLGPMPFEQATALPLILTTAYYSLVETARLQPGETVLIHCAAGGVGQMAIQIAQQIGARIIATVGSPAKRDLLQSRYGLTEAHILSSRDASFVDGVMQLTGGRGVDVVLNSLSGKLLHASWNSLATFGRFIEIGKRDIHENTLIEMDPFRRNVLFASVDMVTIYAQNRALGARIFDHCCNMVHEGRIQLPATILALPYSEAVQGFRLLQMGRHTGKVVLVAEDQGDQVPVSPPTWNAVANRLSPDKTYLLVGGLGGLGRTLTEWLVQRQAKRIAFLSRSGADRPEAQATVAWLRARGIAVSVHAADVADPGHVQACIKAIPDLGGVFHAAMVLADAPLERMSYAQWHRCVQPKVRGAYNLHCATVHCPLDFFVCFSSISAFFGSKAQANYAAANVYLDSLVRYRRQLGLPASSMNCGRITGVGVAAADASLERFMVEEGFDGVNRQELLYQIEEAIFSADHPAPLSGRGTDMSQTLTGVTLERDDVYWAQRSIFRNLYRNHDVEGQSRPGADEVNLSVQLARTIDLSDRVALLMERFVDKVSVVLGLSPESLKPADPVYGLDSLVAVELRNWFTKSVGVDIALFDVLGSPSIQALVEKAIGLFDAQVQQQQQQQQSVQSSSAPSNDDQSPTFNKNLDSQDPSTSLQIPKADCSRPLPMSTFQNRLWVSHRFAADKSRINLAITMHLRGQADHGILEQALSELIARNPILRTAYGEGEAQDEQRVMAPRPFHLGFHDLSKSGPSEGPTASLETLVGSLKRKEMRIEEGEVLEATLVQRSSTECALVLIMHHICTDRSNSQSFVRQLAALYDALRQGRSLSTIPAPKVTYADFTLWHNQLLTSPSMGKGVEYWKQTLAGMPASCQLLPFAKGERPSWDEYGRETVVAALSARQLQRMKRICSQARTSPFHFLLAAFRAFLHRYTADEDLTILMVDGNRPHADLGEVLGFFVNMAPIRCRDACAGSFETLLKTIGGRVLEAMAHSHVPFDVIVAQTQGARTPAHFPVSQVLVNYQQPDEQARYQTTDFTFQGTEVQNMPTGCELSLQAREDAEHGLQLELEYATALYEDGDMRCFFDNFQTFVTSLIQDHRQSIPEVRLAGTLELERLALHCWNSHPPDHGWQPLNLPRRIVEVAETQPRAIAITTSAGEAVTYQDLVASARRVAFSLQNLGIGPGQVVGILASPGIELVTAMLGALFNRCGYVPLDPTMAVGRLAYIVGDSGMQLLLVDEESDPLASSLGRESPSLPNVMSIKNATRAAWPADLPRSLPTDPFYMMYTSGSTGTPKGVPLTQENVGEMLAAMQARFNFTREDRFLHQISPSFDLSVVELFSPLCVGAKLCIATKTTRSDPRLLGDYLRQASVTVTYFTPTQFALVLEHSGASLVACPDYRIALLCGERLPTRLAEAFHQLACAATLYNAWGPTEAAVQTTIHRVQWPADQTLNIPIGHAVGSCRHYIVDAAMNPLPVGFVGEICIGGPQVARGYWNRAESNRQQFLRNPFASPDDHRRGWTRLFRTGDLGRFLPDGQLEFLGRIAGDKQIKLRGFRIDLGEIEHVLHRHSGTPDGQGIVDLAVIAQSAPEDADALTDDRWLVAFIVPKQAIPTEAAKRAYATLLHTRAKPYLNRYMLPAAYQFVDQLPTTASGKTDRRALGASQAPGTPPQHGAGPAAASTLDPAQAQAQDRADEEVGDRTMATVTRVWQEVLRLDHDIPVEPTSNFFDMGGSSTLLLRLQGKLQTTLSIPISLQEMVRRPTLVQLVELVHSKVPREGQPPPTPGSRPEEDVVDWAQETTLPAETRYHPPSAPMSPGGRDILMTGAESFTGIHLLAQLLTSHPSGTIHLLGTHHPWDHAQVFQRLQEYNLLNATLTPEQILTRLRTIPGSLAEGSHFGLSPRAFEALGRSIATIYHLASEVSLLKTYHDLKPINTAAILPLIELARWGGPSPIHYLSTWSVPHLQLWTAPPTTPAVVHEASAGHFTPPPTADQGYFKSRWAAEMLLTHAAARGFPVTIYRASAVTGNPTTGLPAPAGDFVRSLILDMLRHRLVPRFARESPAPVVVDLVPVNYLTALLAHLAQRPRAAAAEGPRPAGVEIFHLTNPTPLPLDQLPGLTGSIRGDATAGRVVSVDDWLAAVSGSDPAAAAADEDEQLRVQVAGGYFRRGHQMFALDRRRTDAALGGVTEGWVDCPPVDANYLRALWLQKV
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster that mediates the biosynthesis of pyranoviolin A, a pyranonigrin analog with a C-3 methoxy group (PubMed:33117309).  Initially, the PKS portion of pyvA synthesizes C-10 carbon chain from 5 molecules of malonyl-CoA, which is then condensed with the thiolation (T) domain-bound glycine activated by the adenylation (A) domain (PubMed:33117309).  The subsequent chain release by Dieckmann condensation (DKC) could be catalyzed by the TE domain present at the C-terminus of pyvA and/or the alpha/beta hydrolase pyvD, installing the tetramic acid moiety (Probable).  The FAD-dependent monooxygenase pyvC next epoxidizes one of the olefins of the polyketide part, and the epoxide ring-opening induces the dihydro-gamma-pyrone ring formation (Probable).  The cytochrome P450 monooxygeanse pyvB would be responsible for the 2 consecutive reactions, in which the dihydro-gamma-pyrone is oxidized to gamma-pyrone and C-7 is hydroxylated to yield pyranonigrin F (Probable).  Finally, the O-methyltransferase pyvH methylates the C-3 hydroxy group to complete the biosynthesis (Probable).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase pyvA, Pyranoviolin A biosynthesis cluster protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.