PharMolix/UniProtQA huggingface dataset:
Protein: XGPT_SERP5
Sequence: MSEKYVVTWDMLQMQARKLAHRLLPADQWTGIIAVSRGGLVPAALLARELGIRHVDTVCISSYDHDNQREMKVLKRAEGDGEGFIVIDDLVDTGGTAKAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMAVTFVPPIGGR
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RL24_LIMF3
Sequence: MFLKTGDKVRVITGKDKGQEGTIKKTFAKENRVIVEGVNKIKKHQKPSNMNPNGGIIDTEAPINASNVMLLDPSTNEPTRVGFEVVDGKKVRVAKKSGKQID
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: PSBM_SYNSC
Sequence: METNDLGFVASLMFILVPAIFLIVLYIGTQNNEA
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: SOML_SCIOC
Sequence: MYMMTALQRGVWASLLWPYLITISIPLDCKEEQGSLSRCPSISQEKLLDRVIQHAELIYRVSEESCSLFEEMFVPFSLQLQRNQAGYACITKAFPIPSSKSEIQQISDKWLLHSVLMLVQSWIGPLAYLQNTMDHYDGAPDMLLNKTKWVSEKLISLEQGVVVLIKKMLDEGILTTTYSEQGLFQYEVQPDMLESVMKDYNLLSCFKKDAHKMEILLKLLKCRQTDIYNCP
What are the official names of this protein?
Somatolactin, SL.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MED5_YEAST
Sequence: MEKESVYNLALKCAERQLTSMEFSNLYKEFFNEKFPSLIQEEEEDTTTTANINEVKKASDLVDTPSNNTAATADTTHLHEALDIVCSDFVKILNLEKPLILADYIVEVLLVNYNSDMIKCFLPKLNSVRNSLLLAHFFSKSCSFFAKLSDTLIIDQVRKDLGNVIVPNILSLDMNSMNKELIAIVSKLLQTTLKLSPSPILLTSAGCKNGSFTLLNQLSQTNKLLFKRVSQTFEAKLHFKDTKPFLNKDSTNEFVGSPSLTSPQYIPSPLSSTKPPGSVNSAAKYKDMKLLRYYKNIWLNNKIINWEISNPDFLSKYSAITSSIFQESFNSVQNLDQLLTDLIETSFTCFAQFVSNKQYHQANSNLTLLERKWVIFITKHLPLLILENSSRSPRVVTNALDNIDEKVVKAIRIYFTEKDDNKTNNEDLFDDYPSTSLDIRHDFIKGLIMLNLQPASVINNYLREDQMIDTSILPTRDDLFVRNLQGIQEVVHNTNSFIISSLDTLELESITESITHDSSNGLFQVLHNFESVAPTKQREIVKAFLSIFEDAIKELNYNRIAKICALLFFNFSHSLTTILSFSSPAALMKTLIKFVDLSRNGRNGSNGNDESSEYETINISLSFSWAILLIINLTQTYGISVVDVALKYPELSIKNSFIINFISNLPNVSDKYYLEESNVNDSDMLTKSHNTVQSWLCDLFVNGSITDQLIQNIETRQLANLIPFIVKQVLLSVEIGVLTDISSLIGGFEYFLQPLLLVGLIKTFYWLEQFLSCVKNDTISEDILQGIFNLLNTLFNPVTLNEDSKAFHTAVLRLNAIPLLKVLRKFRVQSQSNYGIYSSDAQGDPNLEPLIAKLVAVLNVSPVYDVDPRIINSENDYSRKQLGYGKFLILNENPINKIMTNQINSFWSLHSSTYYNLDYLFELIELVTPKSFLFDVLKTLEYKLATYGVPGSENKRGSLDSEHVFDYFFYFLVLYDVKTAEEASQLIEYMENDAKKSKGDVDIKGEDLHEKNDSAEVRQETQPKAEATQDDDFDMLFGENDTSTQAYEEEEENEDNDGNNRTNNVPMIKAEETPSKTNKISILKRHSFAVLLHERKLLNDLALENGEITKTENEKFISYHDKYLCMLKTCVF
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II.  The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 5, Mediator complex subunit 5, Negative regulator of URS2 protein 1.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZAP1_YEAST
Sequence: MDALTPRDSPKRDDSMATSAATAASAKPDALTIGKEGIVHGHIHNYNNLTYIHGHLHHSAPVNDSSASATPAAAAVADAATSAFASGASHDMGGDCHVNEKCKEYTDCQHFEFLNYHNNPSLTKYNDTATYNSNNHSFANNFHSVASDPTSPQQNSKSDLPRRKDSWFNDDLILLPSSKKNKPNPPPGSDDCYCTPKILEICCDETHPKSEANIKQGESDQPTKKDISENGNDVAIFTDVKNDHLMPNFNLHDQYCNSTNHDSHNHNNTVPDSFSQLMSHLSEIDCDLTCDTPCTASTSATSGHKFVQDHQSSNNDDVFHKYCKFCEESTDNQPCSKHMHLESKPPQLPPKCSSLRKPTNTLQGTNHAYHEHILNTDMDLKILEDLCNISSLYEVPFGKHINHHDHNNAGNGCDGSSTGNNENGNQTMNLLLSSINRCNPKNNLNGSNNNTAGATSTDHQHHHHRIQFHSHKPNRNNIVNNSGISAANTTADLTNNDLNDLISREYSYERFRNQSEPPSLPKVTHQNQKNRRSWPTKDLESTDFSSLEDSLPSSISPPIQTTSTINFNWCFKEEKNNDLKCKWKECPESCSSLFDLQRHLLKDHVSQDFKHPMEPLACNWEDCDFLGDDTCSIVNHINCQHGINFDIQFANPDSFLPGSISKEKHHLLHCPNPQTHEVSKADGAPDMTSANDVSNIPPIKQPEQVICQWDGCNKSFSSAQELNDHLEAVHLTRGKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSEETLVQHTRTHSGEKPYKCHICNKKFAISSSLKIHIRTHTGEKPLQCKICGKRFNESSNLSKHIKTHQKKYKCSDCSKSFDDLGKLNSQKVKCALERKPYL
What is the function of this protein?
Transcription regulator controlling zinc-responsive gene expression.  Binds to zinc-responsive elements (ZREs) (consensus sequence 5'-ACCYYNAAGGT-3') in the promoter of target genes (PubMed:9786867).  Recruits SWI/SNF, SAGA, and Mediator complexes as coactivators in a zinc-responsive manner (PubMed:22950018).  Involved in zinc ion homeostasis by zinc-responsive transcriptional regulation of the zinc uptake system genes ZTR1 and ZTR2 (PubMed:9271382).  Positively regulates ETR1 expression, affecting mitochondrial function (PubMed:26711224).
What are the official names of this protein?
Zinc-responsive transcriptional regulator ZAP1.
What are the subcellular locations of this protein?
Nucleus.
Protein: WZZB_ECOLI
Sequence: MRVENNNVSGQNHDPEQIDLIDLLVQLWRGKMTIIISVIVAIALAIGYLAVAKEKWTSTAIITQPDVGQIAGYNNAMNVIYGQAAPKVSDLQETLIGRFSSAFSALAETLDNQEEREKLTIEPSVKNQQLPLTVSYVGQTAEGAQMKLAQYIQQVDDKVNQELEKDLKDNIALGRKNLQDSLRTQEVVAQEQKDLRIRQIQEALQYANQAQVTKPQIQQTGEDITQDTLFLLGSEALESMIKHEATRPLVFSPNYYQTRQNLLDIESLKVDDLDIHAYRYVMKPMLPIRRDSPKKAITLILAVLLGGMVGAGIVLGRNALRNYNAK
What is the function of this protein?
Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS).  Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules.
What are the official names of this protein?
Chain length determinant protein, Polysaccharide antigen chain regulator.
What is the protein family that this protein belongs to?
Belongs to the WzzB/Cld/Rol family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF2_RALPJ
Sequence: MASTTVAQLAGELNRSASALLEQLQAAGVQKATPEDVITESDKTRLLDYLKRAHGSAEDGARKKITITKRETSEIRQADATGKTRTVQVEVKKKRVLVKRDEPNAALAESEASEAAPVVDAEEVARREEEHRRQAELLARQEAELKARQEAMEREEAERRARQEAAEAEQKRQAELAAKKAEEEAVAARAAAEASDEAPRRKAEEDAARLATEREAAQKAADEARVAADKIKAEEDAARKRREAAEAEARAIREMMSAPARVLKTPAERKAEEVKKAEQSGTLHKPVKPAGEARPAAAKKPAAPAPAAAPAPGSPAGDKKGGRGKSGWQDDNRGGKRGGLKTRGDTGGGADGWRSGSKGGRNRHGDDNRNAFQAPTEPVVREVHVPETISVADLAHKMSVKAAEVIKQMMKLGQMVTINQVLDQETAMIVVEEMGHQAVAAKLDDPEAMLVGDVQEQTNAEAETRPPVVTVMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETDRGVITFLDTPGHEAFTAMRARGAKATDIVILVVAADDGVMPQTKEAIAHAKAAGVPIVVAITKVDKPEANPDRVKQELVAESVIPEEYGGDVPFVPVSAKTGEGIDSLLENVLLQAEVLELKAPVNAPAKGLVVEAQLDKGKGPIATVLVQSGTLKRGDVVLAGTAYGRVRAMLDENGKPAKDAGPSIPVEIQGLSEVPGAGEEVLVLPDERKAREIALFRQGKFRDVKLARQQAAKLENMLEQMSEGDVKSLPLIIKADVQGSQEALVHSLKKLSTDEVRVQIVHAAVGGITESDVNLATASKAVIIGFNTRADAGARKLAENHGIDIRYYNIIYDAVDEVKAAMSGMLSPEKREETTGLVEVRQVFHVPKVGAVAGCMVLDGFVKRNSLVRVLRANVVIFSGELDSLKRFKDDVKEVKQGFECGLSIKNFNDVQEGDQLEVYEITEVARTL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDC_STAA3
Sequence: MKKKALLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGSNKKGKNTQVVSKKKKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MELA_ASPTN
Sequence: MQPSLIPSLLETAAARNGDGRVILYSQGNREDPRSITYRDLLETASKASVAVHNHQNYTPGAAVLLHFNNHLDNIVWFWAVLLAGCIPAITPAFSNNPVQRVANLEHLSSTLITDWCLTSQALLVEFAGQDAIEPVSVETLGWEKASPDSNTASVKAKPTDTALLLFTSGSTGKSKAVCLSHFQIVSAIAGKLSVVPLPEQSSFLNWVGLDHVAAIIEIHLQALYADLDQVHVPGSDVISDPIWFLDLMATHRVSRTFAPNFFLARIRDALVQNARSASPRQWDLSGLRYVASGGEANTTKTCDELSQLLKSFGAPLNVIVPGFGMTETCAGAIFNTNCPDYDKKHGLEYTSVGSCMPGIFMRVTNQQGDPLPPGEMGSLELAGPVVFRQYLNNPAATQESFTMDGWFKTGDCGTLDENGYLVLGGRAKETIIINGVKYSPHEIETAVEEHNIKGLSRSFTCCFSSLSPGAETEEIVLVYLPTYAPEDIPARAATADAISKVVLMSTGSRPHIIPLEQALLPKSTLGKLSRSKIKAAYERGEYRTHDSINRSLIARHRQATRASPKNDFEKGLLEIFLRSFKISEDEFDVQTPIFDVGIDSIELINLKRDIEQHLGFADATIPIIILLENTTVRELAAALDNLYRPKEYNPVVTLQAHGDKNPLWLVHPGAGEVLIFINLAKFITDRPVYALRARGFDEGEKPFDSIEDAVTSYYNGVKSKQPHGPYALAGYCYGSMLAFEVAKKLEENGDEVRFVGSFNLPPHIKMRMRELDWKECLLHLAYFLDLITQKRSRELAVELDGLDQDTILQAIIDEADKERYAQLSLSRPFLSRWADVAYELHRIAGDYDPDGRVASMDVFFSIPLAIAAASKSEWRNVHLSQWDDFTRSHVRFHDVPGEHYSMIGPEHVFAFQKILRSALAERGM
What is the function of this protein?
Nonribosomal peptide synthase; part of the gene cluster that mediates the biosynthesis of Asp-melanin, a pigment that confers resistance against UV light and hampers phagocytosis by soil amoeba (PubMed:29305695, PubMed:23841722, PubMed:27133313, PubMed:29270299).  The nonribosomal peptide synthase melA converts 4-hydroxyphenylpyruvate (4-HPPA) to aspulvinone E (PubMed:29305695, PubMed:27133313, PubMed:29270299).  The tyrosinase tyrP then performs hydroxylations of both aromatic moieties of aspulvinone E (PubMed:27133313, PubMed:29305695).  The product of tyrP is highly unstable, and, due to the high reactivity of methides and ortho-diquinones, the polymeric Asp-melanin forms spontaneously (PubMed:27133313).
What are the official names of this protein?
Aspulvinone E synthetase melA, Nonribosomal peptide synthase melA.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SFH5_PHANO
Sequence: MPVVESDEKVDDTAKDLSSLGLSDKETARGEEKEEKGTVAAPSAPTVDTVQPTTGPSWPATAPDHPLSKFYDIFEDVIKSAEHNEVYGILLTKENPFQTKLILQKFLRANQNDLDKAKQQLLETLKWRKEFDPVKATGEKFDKTRFGGLGYVLEVQGVPESKNEKDVVTFNIYGAVKDKKATFGDLEGFLRWRVGLMEKSVQKLNLASATTPVPNYGEGPDPYQGFQIHDYLQVSFLRQDPAVKAATSKTIEVLGRYYPETLSRKFFVNVPVIMGWMYTAAKLIVAKETAKKFAVLSYGNQLAGELGVDIPAVYGGTKEDLESVAEGMSLE
What is the function of this protein?
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity.  Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.  Heme-binding protein that may play a role in organic oxidant-induced stress responses.
What are the official names of this protein?
Phosphatidylinositol transfer protein SFH5, PITP SFH5.
What is the protein family that this protein belongs to?
Belongs to the SFH5 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: TRI65_MOUSE
Sequence: MAAQLLEEDVVTCSICLGRYRDPVTLPCGHSFCGNCIQDSWRSCEKSCPECRQPFPEGAKLSRNVKMSTLLQALPVLPAPPAVTPRRDSATSHSARCLRHGRPLEFFCRTEGLCVCSACTVHDCSHHERALLDVERRVREDQLRARVLVTQQQVAQAETQLQELQEQRSRIESSACTLASVVSRRFSSLLQALEKQQASTLSDIEVAKKQALGQVLNEKQRLTDHLRALSQYDQSVQDLLAQADDCIFFQELQQLPEPTESLGPLTSPQWNEEQQLSNVNQLLSPLCELLLEEKSLPKVAAKAADAGPLETLGPLAPVPSAVCPLRKKLWQNYRNLTFDPETANQYLHLSHKDQRVTHHFQAQGPAKSGSFELWQVQCTQSFQTGQHYWEVRVSDHSVTLGVTYPKLSRQKLGTHTDNIGRGPCSWGLCIQEDSMQAWHNGKSQRLRGLPGQLLGVDLNLTSGCLTFYSLEPRTQPLHTFYAVFSQPLFPVFWLLEGRTLTLCHQPEATLPARPQEEATAPS
What is the function of this protein?
E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:31310649, PubMed:34512673).  Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs.  This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (By similarity).  Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade.  Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (By similarity).  Plays also a role in limitation of inflammation through different mechanisms.  First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649).  In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM65, Tripartite motif-containing protein 65.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
Protein: TEX29_BOVIN
Sequence: MRYAPEFKKSPSHLLKKFAVCDIPLYDICDYNVSRDRCKELGCCFYKGICYEKAVPSYVQVFSALIVIIAGAFVITIIYRVIQESRREKEVPTEAPVSAKSSVQVETQPPSSAGAGSKAPSVERPQSKESGREDASLIVTEEEETED
What are the official names of this protein?
Testis-expressed protein 29.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: SYA_CUTAK
Sequence: MRTAEIGQRFVDFFESKGHTVVPSASLLYNDPTLLFVNAGMVPFKPYLMGTEPSPWKRATSIQKCVRTLDIDEVGKTTRHGTFFQMLGNFSFGDYFKNEAIQYAWELVTKPAEQGGLGFDPASIWVTVLGPGFHPDYPEGDIEAREAWRAAGIPDEQIQGRSLKDNYWHMGVPGPGGPCSEIYIDRGPAYGPDGGPEADEDRYLEIWNLVFETEDLSAVRAKDDFDIAGPLRSLNIDTGAGLERIAYLLQGVDNMYETDQVFPVIEKASEMSGKRYGARHDDDVRLRVVADHVRSGLMLMTDGVTPGNEARGYVLRRLLRRVVRAMRLLGVADPVLPELLSVSRDLMADSFPDVLTQWDRVIGAATAEEDTFRRTLSSGTAMLDAAVVETKASGSKTLSGEKAFQLHDTYGFPIDLTLEMAAEQGLEVDRNKFTALMAEQRARAKADSQAKKGLLTDREAYSQVRALGETPFLGYTDLTVDTTVTGIIANGTSVTAAEPGAVVEIVLAETPFYAEMGGQDSDSGIIRANGIDFEVLDVQRPVPGLIVHKVHLDGDLAVGDRVTALVNPATRFGACQAHTATHVIHAALRELVGPSATQAGSYNKPGYLRFDFSATKGLSDSLKDEIEERCNVAIHDDFEVTDTQMPLEDAKAMGAMAMFGEKYPPIVRVVELAGPWSRELCGGTHVASTGRIGMLSLLGEQSVGSGTRRVEALVSTDAFRHMAAERALVNELTGILKVQPDQLADRVSKLAADLKEAERKLGAARTRELLGQVDDIVAGTTPAGSFDLVAAKVPGVAGSDLRTLAAEIRARVKDRPAVVTLIGGTHDKPAMIVATTESARAAGAKAGALIKVGVAPIGGRGGGKDDMAQGAGSDPTGIDAALRAVNTELTAL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCJO_ECOLI
Sequence: MNRLFSGRSDMPFALLLLAPSLLLLGGLVAWPMVSNIEISFLRLPLNPNIESTFVGVSNYVRILSDPGFWHSLWMTVWYTALVVAGSTVLGLAVAMFFNREFRLRKTARSLVILSYVTPSISLVFAWKYMFNNGYGIVNYLGVDLLHLYEQAPLWFDNPGSSFVLVVLFAIWRYFPYAFISFLAILQTIDKSLYEAAEMDGANAWQRFRIVTLPAIMPVLATVVTLRTIWMFYMFADVYLLTTKVDILGVYLYKTAFAFNDLGKAAAISVVLFIIIFAVILLTRKRVNLNGNK
What is the function of this protein?
Probably part of the binding-protein-dependent transport system YcjNOP.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Inner membrane ABC transporter permease protein YcjO.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SLMA_SHEPA
Sequence: MAASPKINRREHILQCLATMLETSPGQRITTAKLAAEVGVSEAALYRHFPSKARMFEGLIEFIEESLLSRINLIMDEEKDTMKRCQQLLQLLLVFAERNPGISRVLNGDALLGENERLRSRISQLFSKIETHLKQILREKSLREGKGFELDEAVLANLLLAVAEGRIAQFVRSEFKLKPTKHFNEQWNFIQQQLLQS
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: VM2V2_CROVV
Sequence: MIQVLLVTICLAVFPYQGSSIILESGNVNDYEVVYPRKVTALPKGAVQPKYEDAMQYEFKVNGEPVVLHLEKNKGLFSEDYSETHYSPDGREITTYPLVEDHCYYHGRIENDADSTASISACNGLKGHFKLQGELYLIEPLKFPDSEAHAVFKYENVEKEDNAPKMCGVTQNWKSYEPIKKASQLNLTPEQQRFPQRYIELVIVADHRMFTKYNSNLNTIRIWVHEIVNTINVFYRSLHIVVSLTDLEIWSNQDQINVQSAAADTLEAFGEWRETVLLNRISHDNAQLLTAINFQGNIIGRAYTGSMCDPRKSVGIITDHSAINLWVAVTMAHELAHNLGISHDGNQCHCDANSCIMSEELSEELSFEFSDCSLNQYQTYLTDHNPQCMLNEPLGTDTVSRNELLEAGEECDCGSPANPCCDAATCKLRPGAQCAEGLCCDQCRFIKKGKICRRARGDNPDDRCTGQSADCPRNRFHA
What is the function of this protein?
This recombinant protein inhibits ADP-induced platelet aggregation in whole human blood and this effect is concentration-dependent with an IC(50) of 34 nM.
What are the official names of this protein?
Zinc metalloproteinase/disintegrin VMP-II.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIe sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EIK2_PLAF7
Sequence: MLINKRKRRKAYIYNDGYEYINKKIKNKFIFICLIAVGGFSCVYKIKKKEKKEKKGKKKKEKYYYDQKQNCKDKFYALKKIKFHANPKNLKEQILLNLREIKYLNLLKKYTNIVYPHEYWIEIYKPFYKQKKIKSDKKKKNKKKIKKQKLSLFKDTIKIIKKRKKDKLKKKKKIEFFFKNIQYSSDTDDIKITFEDAHPEKVKNNNNIKDIKYIKKKVQKDYKKNNKKNDKNNVNKNNTYNNKYKVVINKIIGKKYIINKIKINRNKKIYIYRHMYGHIYGHMYGHMYDLFNINKNSYYTYNNNNNNNNNDKFKSLKGLKRNNLFINKNQTIPYPSSCYYYSSHTTNKFKSLNEKQFTYVSSFSSHMWCTASRRKTFSYNQKDNYQEIKKLNKYYNYKSSNFLDKQILNKQSMFYQNKINNKKNDHNVVLKTLQTFYDDTYIYNLENVDTQETKQYSNYNNIENVKNVKNVKNVENVKNVENVENIEDMKKKKKNKFVIYNNIYTMQNIKYTSYKSNVFFIDHDVNICNSYSLPNIFTCKTKNKHNAFFFPRHTKFNNRPSKNKKYRLSQRKYYINNYKNKGIKFKLKKIIRKMFQMKNKLRCVTGTYINNYKIGKTIVKNNKKNIKNNNNNKKNNNNNTNKKKYYFYNQHSPCIDIFKKTKRRKKKKKKKKKKKKITFINLLFNNQIKYQTKNCKNKINNIQSRECAHKILSCHHVFILLYYIYKNKTSISELLYEQYINNIKKNFLINKLINLYIPIYNYSEYSFNISFIYYILSNKKRKQFKPTNILSPQVYSYFYYSNVLFGSRYVHQKKKIHRNIHKSKLSNMYAHLSNLDLFLCYRNKHIYKYIKKRQALFNFFFYKRSYITHYEKYFTNKHFIKTQKSQLKHFTRRPTLKMSENNYSSKNYILKKCYMFKIKKKIVKNVNIRRNKNMCMYLSYVIHIIKSHNLCNKINKEFNKQLTNNVCKKKVARQIILDIFYNKTHPRHHIIKYTYNFYKKNICLSGCKKRIFLKIYCFHKGGYVFSRLYGREIKKKKKIERIRNIQVQKQMDYKSRPFINNKRSSKISKQIIYFSLNIILKNYIDYILRKRYFLCSYDHNLIERKWLMYYFTKVVSKYFLNPRKDNNNNNIMFNNNNIMFNNNNIMFHNNNIMFHNNNIMFHNNNIMFHNNNSMFNNNNIMFHNNNIMFHNNNIMFNNNNIMFHNNFIVNNYMDKYKNMFIKSCNDKSIPYQMLANLQNEYYLSKGNNNKMNITTTYLYMKIRKILNKYSKRNEEKKNILKGKYCYNNGNFALLSYINKKHKHNKRYHQIKEKNGNNKETKYKFNLYIRMEYCKSTLENYINTRENMNINRNYEIIQMIILGLYSIHNNNIMHRDLKPSNIFISDNNIVKIGDFGLASYDYTYPKNRKRKKRKRKSSNLSYEYNIRKTNILNLQKNNTPFNIDKYNNNIIRKKKEILFKNCCTKNNIPTKEINSNSSFQYFTKKKKKKKNVHDHHTLGIGTKIYAAPEQLIGNKYTKAVDMFSLGLIIVDLFTITKTNMERMKILCNARHRILPDLLIKNHPQVAKLCQNLLSLDYHLRWTSEELYKKKKNIYIY
What is the function of this protein?
Phosphorylates translation factor eIF2alpha in salivary gland sporozoites during dormancy, which leads to an inhibition of protein translation and accumulation of stalled mRNAs into granules.
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase 2, PfeIK2, eIF2alpha kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Protein: PTH_TRIL1
Sequence: MDTIVIAGLGNPGSKYQWTRHNAGFLFLDRIAQLEGLSIVRKQFGGLTAEWERKGKRLVLLKPQTFMNLSGRSVMPALQFYKLKPDQLIVVHDEIDLALGAARLKQGGGHGGQNGLRSIMELLGKGDFVRLRLGIGRPPHGDVTNHVLGVFTPPEMEIFARVLDGALDMLETALDEGVPKAMSLFNNKSYLEG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KATG_MYCSJ
Sequence: MSSDTSDTRPPHSDSGTQSNSESENPIIDSPEPKAHAPLTNKDWWPEQVDVSVLHKQNDKGNPLGEDFNYAEAFAQLDLEAFKRDVIEVIQTSQDWWPADYGNYAGLFIRMSWHAAGTYRIFDGRGGAGQGSQRFAPLNSWPDNANLDKARRLLWPIKQKYGNKISWADLIAYAGNAALEQSGFKTAGFAFGREDIWEPEEMLWGQEDTWLGTDKRYGGTNEDKRELAEPFGATTMGLIYVNPEGPEGKPDPLAAAHDIRETFGRMAMNDEETAALIVGGHTLGKTHGAADVNVGPEPEGAPIEEQGLGWKCPFGTGNANDTVTSGLEVIWTGTNSEWSNRYLEILYGNEWELTKSPAGAWQFEAKNAEATIPDPFGGPPRKPTMLVTDVSMREDPIYGQITRRWLDHPEEMDEAFAKAWYKLMHRDMGPISRYLGPWVAEPEIWQDPVPDVDHELVDESDIASLKSKVLESGLTVQQLVKTAWASASSFRGTDKRGGANGARVRLEPQRSWEGNEPAELAKVLPTLEQIQQDFNASASGGKKISLADLIVLAGSAAVEKAAKDAGYEIDVHFAPGRTDASQEQTDVESFAVLETKADGFRNYIRPGQKTSVEKLLVEKAYLLDLTAPEMTALLGGLRVLNVNHGGSKHGVFTNSPGALSNDFFVNLLDMNTAWKPSENTENVFEGRDRATGEIKWTATANDLVFGSNSVLRGIAEVYAQDDSKDKFVEDFVAAWVKVMNNDRFDLEKF
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: NQOR_PARP8
Sequence: MARVLVLYYSSYGHIEKMAEAIAEGARGAGAQVDIKRVPETVPEEIAKKANFKLDQQAPIATVADLEQYDAIVVGTGTRYGRISSQMAAFLDQTGGLWMRGALNGKVGAAFASTATQHGGQETTLFSIITNLMHLGMIIVGLPYSHQGMMNMTEIVGGAPYGATTIAAGDGSRQPSAIDLEGARHQGELVAKTAAKLFG
What are the official names of this protein?
NAD(P)H dehydrogenase (quinone), Flavoprotein WrbA, NAD(P)H:quinone oxidoreductase, NQO.
What is the protein family that this protein belongs to?
Belongs to the WrbA family.