PharMolix/UniProtQA huggingface dataset:
Protein: PFF1_ASPFC
Sequence: MARPSLSPSNPLGFTPWPVTVITAVVYLALVVPLLVVHHVVPSAPSSSPKGLNLTEAWADLQELTHGFHPYNSHRNDEVHEWLLKRILELIDSAPPASEYGSVGEEKPDIVVFDDTQSNLTFSGRGSGLGVYFESTNIMVYIRGWEEDRERWWEDPHGRPAGKGGVLVNAHYDSVSTGYGATDDGVGVVSCLQLIKYFTTPGHVPRRGLVLLFNNGEEDFLNGARVYSQHPISQLPHTFLNLEGAGAGGRATLFRSSDAEVTKPYMRAPHPFGSVLSANGFEAGLISSQTDYVVFEGDLGLRGLDVAFMEPRARYHTDEDDARHTSLASVWHMLSAAVATTEGLVSDASSRFEGLPREDGRIASGSGPKGVWFDLFGSAFVVFELHTLFALSVTLLVVAPLVLLVTSIALARADKMYLFRSSASPEDSDGSEVVPLHGVRGFFRFPFLLVIPTAVTVGLAYLVTKFNPYIIHSSEYAVWSMMISAWVFLAWFVSRVADFARPSAFHRVYTLTWLFLVEWVFLVISTVYENQYGLAGGYFVLFVFAGTFLATWISYLELFALPRKSDYATQLALPSRRTSSHGSRLGTASGEDVEDGEDEDDDGTTAEATETTSLLRGQRTTFANYVRVTGDYLRDDDEEPRQPNLYGHEQAWSIHLPKWVWVLQFLLTAPLVLIFVGPLALLLTSALRQTGQDGSPSLFIYIAVAALTTLLFIPLLPFIHRYTHHIPLFLLCVFAGTLIYNLVAFPFSPANRLKLFFIQEVDLDTGVNHASLSGAYPFVHDVARRLPSTAGQNITCDLAMLRPKCSWHGIPPQVVQPAAASKMEDWLSYNITKSDSEPKAQLSISGRNTRACKVVFDRPVLDFQVADSAYDPRFPHVSPDGTKEIRLWSREWGHTWTVDVEWAADAEETDEKGPGLSGRVVCLWSDGNSAGVIPALDEVRRYAPVWAGVSKLSDGLVEGSRRFEV
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: SIK3_HUMAN
Sequence: MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSPRHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNADSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSPLLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPARPSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV
What is the function of this protein?
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor.  Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230).  Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable).  Prevents HDAC4 translocation to the nucleus (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase SIK3, Salt-inducible kinase 3, SIK-3, Serine/threonine-protein kinase QSK.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.
Protein: GALA_PIG
Sequence: MPRGCALLLASLLLASALSATLGLGSPVKEKRGWTLNSAGYLLGPHAIDNHRSFHDKYGLAGKRELEPEDEARPGGFDRLQSEDKAIRTIMEFLAFLHLKEAGALGRLPGLPSAASSEDAGQS
What is the function of this protein?
Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3.  This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
What are the official names of this protein?
Galanin peptides.
What is the protein family that this protein belongs to?
Belongs to the galanin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PYRF_THEP3
Sequence: MFIDRLIENIKSKKSPVVVGLDPRIEMTPQFIKDIAFKKRGENIEGVCEALYLFNKGIIDAVYDIVPAVKIQVAFYEAYGIEGFKAFFKTAEYAKSLGLMVIADVKRGDIQEVAKMYSKAYLQNQLFDAITVNPYMGEDTIMPYVEDAIKYDKGIFALVKTSNKGSKDIQDIKTTKGEYVYQSVARMINRISNSAIGKYGYSSIGAVVGATYPEEAKVLRKEMPNCFFLVPGYGAQGGTVEDIMDCFDENGFGAIINSSRSVIYAYQTPYWKDVYSEYEYAQAARAEVILMTGMINNGLVKRKYIAC
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: EIF1B_MOUSE
Sequence: MSTIQNLQSFDPFADATKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLLEVGIVKEEQLKVHGF
What is the function of this protein?
Probably involved in translation.
What are the official names of this protein?
Eukaryotic translation initiation factor 1b, eIF1b.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: RL17_NOCFA
Sequence: MPKPKKGARFGGSASHQKAIFANLATALFEHGRITTTEAKAKAVRPYAEKLITKAKAGTLADRREVLKVIRNKDVVHSLFAEIGPSFEGREGGYTRITKTLPRKGDNAPMAIIELVREKTVTNEADRARRVAASKKAEEQAPAAEAEEQAPAAEAEAPAADAAAEAKADEAAEDKKDA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: TM247_HUMAN
Sequence: MAAEDREMMEARGAGESCPTFPKMVPGDSKSEGKPRAYLEAESQKPDSSYDYLEEMEACEDGGCQGPLKSLSPKSCRATKGQAGDGPKPAELPPTPGTERNPEMELEKVRMEFELTRLKYLHEKNQRQRQHEVVMEQLQRERQHEVVMEQLQQEAAPRLFSGGLQNFLLPQNQFAMFLYCFIFIHIIYVTKEMVFFLFAKHYLFCIAAILLCLIKTFWS
What are the official names of this protein?
Transmembrane protein 247.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: AAK1_HUMAN
Sequence: MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL
What is the function of this protein?
(Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue.
What are the official names of this protein?
AP2-associated protein kinase 1, Adaptor-associated kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Presynapse. Note=Active when found in clathrin- coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells.
Protein: MAZE_STAAS
Sequence: MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
What is the function of this protein?
Antitoxin component of a type II toxin-antitoxin (TA) system.  Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity.
What are the official names of this protein?
Antitoxin MazE.
What is the protein family that this protein belongs to?
Belongs to the MazE/EndoAI family.
Protein: CCSD_UNKP
Sequence: MITPLTLATLSKNPILVDFFDPEDGRWNSHVDLGLWSDLYLIAPATANTIGKMAAGIADNLLLTSYLSARCPVFIAPAMDVDMLMHPATQRNLGILKSSGNHIIEPGSGELASGLTGKGRMAEPEEIVREVISFFSKKKITEKPLNGRRVFINAGPTIEPIDPVRFISNYSSGRMGIALADAAAAMGAEVTLVLGPVTLRPSSQDINVIDVRSAAEMKEASVEAFRECDIAILAAAVADFTPLTTSDKKIKRGSGEMVINLRPTEDIAAELGKMKKKNQLLVGFALETDDEITNASSKLKRKNLDMIVLNSLKDPGAGFGHETNRITIIDKSNNIDKFELKTKGEVAADIIRKILTLVH
What is the function of this protein?
Catalyzes the decarboxylation of L-cysteine to cysteamine and of 3-sulfino-L-alanine (cysteine sulfinic acid) to hypotaurine (PubMed:17420004, Ref. 2, Ref. 3, PubMed:29796005).  Also catalyzes the decarboxylation of various amino acids such as L-lysine, L-glutamate, L-asparaginate and L-proline (Ref. 2).  In vitro, shows highest activity with L-cysteine as substrate (Ref. 2).
What are the official names of this protein?
Cysteine/Cysteine sulfinic acid decarboxylase, Cysteine decarboxylase, L-cysteine sulfinate decarboxylase, CSD, Sulfinoalanine decarboxylase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PPC synthetase family.
Protein: TRPD_BACP2
Sequence: MNQRLSALVNGGFLSENEAHQLMHDMMSGSLTDAEVAASLSILAHRGETAEEMTGFVRAMRQKAEPAERSLDVVDTCGTGGDGLSTFNISTAAAIVASAAGAKIAKHGNRSVSSKSGSADVLECLGIHIQSTPEETRRQIQEKNMGFLFAPMYHSSMKQVAAVRKQLGFRTVFNLLGPLCHPMQAKKQIIGVYAKEKAKLMAEALAPLEPEHVLFVCGEDGLDELTITANSYVIELKKGDMTEYTLNPEDFGLAKGYLSDIQVQSPEESAKLIQNILNHQTEGAPLHITALNAGAALYVAGKSESLMAGTLKALETIKNGAAKEQLARLKQKTKEEEIYA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: CH60_FRAP2
Sequence: MAAKQVLFSDEARAKMLDGVNTLANAVKVTLGPKGRNVVLDKAYGAPTITKDGVSVAKEIELEDKFENMGAQIVKEVASKTADVAGDGTTTATVLAQALLTEGLKAVAAGMNPMDLKRGIDKAAAKLVEELKVLSKPCSDTKSIEQVGTISANSDSTVGKLIAEAMAKVGKEGVITVEEGKGFEDELDVVEGMQFDRGYLSPYFATNQENMTTDLESPYILLVDKKISNIRELLPVLEGVSKSGKALLIIAEDVESEALATLVVNNMRGVVKVCAVKAPGFGDRRKAMLEDIAILTGATVISEDLGMKLEEANMEHLGTASRVQVSKDDTTIIDGAGNKDAIVNRVNQLKANVAEATSDYDKEKLQERLAKLSGGVAVIRVGAVTEAEMKEKKDRVDDALHATRAAVEEGIVAGGGVALIRAQKALDGLVGDNDDQNHGIALLKKAIEAPLRQIVSNAGGESSVVVNEVKAKEGNYGYNAANDTYGDMVEMGILDPTKVTRSALQHAASIAGLMITTEAMVAEIKEDAPAMPMGGMGGMPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_YERPP
Sequence: MSTIEERVKKIIVEQLGVKEDEVKNSASFVEDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDFINANQQ
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURA_KLEP7
Sequence: MDKFRVQGPTRLQGEVTISGAKNAALPILFSALLAEEPVEIQNVPKLKDIDTTMKLLSQLGAKVERNGSVWIDAGPVDVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHISGLEQLGAEIKLEEGYVKASVSGRLKGAHIVMDKVSVGATVTIMSAATLAEGTTIIENAAREPEIVDTANFLNALGAKITGQGSDRITIEGVQRLGGGVYRVLPDRIETGTFLVAAAISGGKILCRNAQPDTLDAVLAKLRDAGADIETGEDWISLDMHGNRPKAVNVRTAPHPGFPTDMQAQFTLLNLVAEGTGVITETIFENRFMHIPELIRMGAHAEIESNTAICHGVKQLSGAQVMATDLRASASLVLAGCIAEGTTIVDRIYHIDRGYERIEDKLQALGANIQRVKGE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLV_CAMC5
Sequence: MFHATTILAYKGKNKSVIGGDGQVSFGNTVLKGNAVKIRKIKDGKVLAGFAGSTADAFNLFDMFEENLEHAKGDLLKAVIEFSKAWRKDKYLRKLEAMMLVLNREKIFLLSGTGDVVEPEDGKIAAIGSGGNFALSAARALDKFADIDEEKLVKESLTIAGEICIYTNTNIKTYVIEDEK
What is the function of this protein?
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
What are the official names of this protein?
ATP-dependent protease subunit HslV.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family. HslV subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF2_THET8
Sequence: MRLASQSAILVKVWTWNASRNAWKASGGIFDIPQKETRLKELERRLEDPSLWNDPEAARKVSQEAARLRRTVDTFRSLESDLQGLLELMEELPAEEREALKPELEEAAKKLDELYHQTLLNFPHAEKNAILTIQPGAGGTEACDWAEMLLRMYTRFAERQGFQVEVVDLTPGPEAGIDYAQILVKGENAYGLLSPEAGVHRLVRPSPFDASGRRHTSFAGVEVIPEVDEEVEVVLKPEELRIDVMRASGPGGQGVNTTDSAVRVVHLPTGITVTCQTTRSQIKNKELALKILKARLYELERKKREEELKALRGEVRPIEWGSQIRSYVLDKNYVKDHRTGLMRHDPENVLDGDLMDLIWAGLEWKAGRRQGTEEVEAE
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (Probable).  In endogenous ribosomes interacts with P-site tRNA and 23S rRNA (PubMed:18988853, PubMed:20421507).  In the presence of truncated mRNA in the 70S ribosome, ArfA and RF2 interact such that the GGQ peptide hydrolysis motif of RF2 rises into the peptidyl-transferase center and releases the ribosome (By similarity).  Recruited to stalled E. coli 70S ribosomes by E. coli ArfA, but cannot be functionally accomodated in the peptidyl-transferase center (PubMed:27934701, PubMed:28077875).  Note T. thermophilus probably does not encode arfA (Ref. 1).
What are the official names of this protein?
Peptide chain release factor RF2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRYZ_DROER
Sequence: MSSSSWLGCLLAVLLSALALSQGLPLLEDLDENSFPDGRIVGGYVTDIAQVPYQITLRYKAISSPENPFRHRCGGSIVNETTILTAAHCVIGTVASQFKVVAGTNFQTGTDGVITNVKRVIMHEGYNSGAAYNNDIAVLFVDPPLPLNNFTIKAIKLATEPPLDGAPSKISGWGSTYPGGYSSNQLLAVDVPIVGNDLCDLDYENFIDETYHITSAMLCAGKRGVGGADACQGDSGGPLVVRDELHGVVSWGNSCALPNYPGVYANVAFLRPWIDAVRAGL
What are the official names of this protein?
Trypsin zeta.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: YET4_SCHPO
Sequence: MTTNPDIVKQTKNEIHQVTSRVQEKLDSKSTNAVEQNNNSSQASVTKDNKKKAAKRAKKKAAKKKKQSAAASASSTPVEEAQHAQEEQQEQTILQEPGFTQTIVEKDADQVDEPLEPIASSALGTVEPPTDNKPSASTSTAVPTTEARNTSITEPANSPSSSSSSASTKSTATTQSADYVVAEHFAPQRNDEQLGNSPASITSKPATTSAAQPSSKVEENMAKATSQPITTAEKEIPELKPIEPEAIMISKEINTTHDQAAATTTAAVASASTTATAESHAVADGIMNDNVLESIGENVQQETVFEDASDIPHADVIPHTTTVTVEEESPIALGQGGVTHEATTSARASASGIPGAFEEVQQTVQEDLPHPTAETVEIARFAEQPVRAQQPEQYESSVVQEATETVTDVGKGVSSTVKNEVNVPSTIPTESENPVAVGGTTAEHPVQEAVTAPTETAHDFSKETTTASKRVSKHDKASAEKHKVARKPSSTGQEPTTPSTPAKSAQSSKHARRPSKQASAPSSPGTTSAAVPGGKKSAIEAAAPIPTSADTVESKHAAGSGSATTIPSPGSATTKPTPGSATTKPTPVSATEEHAAGTTKPAPAAGATATAENETADGKAQTATDGEAAPKKSWFKRMKKSFGKLFH
What is the function of this protein?
Has a role in meiosis and sporulation.
What are the official names of this protein?
Meiotically up-regulated protein C8C9.04.
Protein: ROK1_CRYNJ
Sequence: MASAFSLLTAGGAKFDKNRFKDDFQLFEAKKRKDRKGKSKQIDTLATGSALPSSLDFFGDHPHPQHKPEPEPESESESDFESDSGSSSTSIPAPPPQKITLTGAEPLPKSLHTNLPSLVNHESHSLTSAEGGPLLSALSRANIHSLWGVQCAVGGCLLEDRDTLCVAPTGSGKTLSYVLPTIVKLREPARKLKGTEEGKGVRALVVVPTHDLAVQIQGVIKAVTMGRHWRSMVLTKATEKAVWESAPGEAVKTGEDGDSEIKDGEDSGDEEEDEDDNGSTGSVDEFAPKVSGNPEGLGIDMLVATPERLHHLIDSRRISLARTKYVILDESDRLLSSDFLPQVEPILSACSNPAVQKCFLSATMPAGAESLAKKWLKDGGVRVVVGVKDSAVTTVDQSLLYTGSESGKLLALRNLISSGQLPYPSLIFVQSIDRAEELYKTLVLDGIKVDAVHGGKAKTKRDEAIKDFRVGAVWMLVVTEVLARGMDFRGVKVVINYDFPQTVPSYIHRIGRTGRAGRPGKAITFFNIEDGPYLRTIANVLRSSGCPVPEYMLDMKKPTKNEKKKLAKAPPKRKAVGGGGRDLNREAGKKKKQMVEASKKRKMLERKGKGGNEEKNDDEE
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase ROK1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: TRUB_BACCR
Sequence: MEGVVLLHKPKGMTSHDCVFKLRKILREKRIGHTGTLDPDVTGVLPICVGRATKIAQFLTSETKTYEGEVTLGFSTTTEDASGEVVETKNVDRTITRMEVEKVLAELTGTIEQMPPMFSAVKVNGKKLYEYARAGQEVERPVRTITIHEFVLLDDREVFEGENISFRFRVTCSKGTYVRTLAVMIGEKLGFPSHMSHLVRTASGEFLLEDCISFEEIEENVQNGTVESIFISIDEALSKFPKMVVDEKQAEKIKNGMFLKNELEITAPFITVFDKNDRCLAIYEHHPKHPGMLKPMKVLVNNQELKL
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: SST_HALAF
Sequence: MPDARRFIELPGPVRMYRGGELPSVTIAYETWGELRGQGDNALLLFTGLSPSAHAASSMADPSPGWWEYMIGPGKPIDTERFFVIAINSLGSCFGSTGPASINPATGQPYRLDFPKLSVEDIVAAARGACRALGIDHVHTVAGASLGGMDALAYAVMYPGTYRDIISISAAAHATPFTIALRSIQREAVRADPAWAGGNYAPGEGPKDGMRVARQLGILTYRSAEEWLQRFDRERLEGSDDSANPFAMAFQVQSYMEANARKFADRFDANCYLYLSQAMDLFDMAEHGDGSLEAAVRRIDAKRALVAGVTTDWLFPLWQQRQVAELLEHAGVAVSYHELGSIQGHDAFLVDSERFAPMVAEFLAHSS
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine.  In vitro, has also homoserine succinyl transferase activity.
What are the official names of this protein?
Serine O-succinyltransferase, SST, Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2718_NITOC
Sequence: MKQKILLCSDLDRTLLPNGHQAESPQARLRLQRLAQRPGIILAYVSGRHKALIQSAIREYDLPLPDFAIGDVGTTIYQITDNQWHPWEDWSKEISQDWQGINQAGLAKLFADITPLRLQEPEKQNRYKLSYYAPPELDWENLIPQLAQRLQAQGIQASFIWSVDETAQIGLLDILPKRANKLHAIRFLMERQHFDKSHTVFAGDSGNDLEVLASGLQAILVRNAQEEVRQEALRRLPPEHSQQLYLARGGFMGLNGYYSAGVLEGLAHFFPETRAWMETGREESAEEETAQSCAIYRSCKRNDSYLYVESQDDFSRVPGKLLEMLGKLEFVMRLELRPEISLAQANTREVMQMLREKGYFLQLSSREYRRS
What are the official names of this protein?
Putative HAD-like hydrolase Noc_2718.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HAD-like hydrolase superfamily.
Protein: DF109_ARATH
Sequence: MDFTKKILVVFAFTIMLGISSVHCRPSFKPIPLFGEKLTQCFDTRPCLQGMLKCIEFCSSMGTADGQCNNENLCCCTHE
What are the official names of this protein?
Defensin-like protein 109.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: RADA_HALH5
Sequence: MAKKKTKFMCQECGYESAKWMGKCPGCQSWNSMVEEFTEVKAKSSRSYVTSGAGIAKPQPITKVEREQEPRIDTSMKELNRVLGGGIVPGSLVLVGGDPGIGKSTLLLQLSARLADLKQRVLYISGEESVKQTKIRSDRLGVLSDHLYVLAETDMEKIEQAIGEVDPTLVIIDSIQTVYQDEITSAPGSVAQVRECTASFMRIAKTTGVAIFIVGHVTKQGAIAGPKLLEHMVDSVLYFEGERHHTYRILRAVKNRFGSTNEMGIFEMKESGLEEVANPSEIFLEDRSSGVAGSTVVASMEGTRPVLVELQALISPTSFGNPRRMATGVDHNRISLLMAVLEKRVGMLLQNQDAYVNVAGGVRLDEPAIDLGIAVSIASSFRNQHTNPHEVVIGEIGLTGEVRRVSRIDQRVNEAAKLGFKRVIIPDKNLGGWTIPSTIEVIGVSTVQDALEVTLGR
What is the function of this protein?
DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks.  Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster.  Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB.  Does not have RecA's homology-searching function.
What are the official names of this protein?
DNA repair protein RadA, Branch migration protein RadA.
What is the protein family that this protein belongs to?
Belongs to the RecA family. RadA subfamily.
Protein: RANBM_ARATH
Sequence: MNSSPPPANSANGDTTNNGENGQDLNLNFLDKIRLSAKRDAKEDEGEELPTELNTINSAGGFLVVSPDKLSVKYTNTNLHGHDVGVVQANKPAPIKCLTYYFEIFVKDSGIKGQIAIGFTKESFKMRRQPGWEVNSCGYHGDDGYLYRGQGKGEPFGPKFTKDDAVGGGINYASQEFFFTKNGTIVGKIPKDIRGHLFPTVAVHSQNEEVLVNFGKKKFAFDIKGYEASERNKQQLAIEKISIPPNIGYGLVKTYLLHYGYEETLDAFNLATKNTVPPIHIDQENAIDEDDSSYALKQRKNLRQLVRNGEIDTALAELQKLYPQIVQDDKSVVCFLLHCQKFIELVRVGKLEEGVNYGRLELAKFVGLTGFQDIVEDCFALLAYEKPEESSVWYFLEDSQRELVADAVNAAILSTNPNKKDVQRSCHLQSHLEKLLRQLTVCCLERRSLNGDQGETFRLRHVLNNNR
What are the official names of this protein?
Ran-binding protein M homolog, AtRanBPM.
What is the protein family that this protein belongs to?
Belongs to the RANBP9/10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Associates predominantly in the form of large cytoplasmic complexes.
Protein: PRGC1_RAT
Sequence: MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSVLSRGHEERKTKRPSLRLFGDHDYCQSVNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSSQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDKVDKTSELRDGNFSNEQFSKLPVFINSGLAMDGLFDDSEDENDKLSYPWDGTQSYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEANEHERLKRDEYRREYEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR
What is the function of this protein?
Transcriptional coactivator for steroid receptors and nuclear receptors.  Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter.  Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.  Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism.  Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (By similarity).  Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.  Also involved in the integration of the circadian rhythms and energy metabolism.  Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity).
What are the official names of this protein?
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body.