PharMolix/UniProtQA huggingface dataset:
Protein: ZEB1_GIBZE
Sequence: MKLSPSKYLPVLLGTLSLTIANPSADCKCFPGDDCWPSAAEWKALNTSVSGNLIKTVPLGAPCHDPMFKGDVCQSLRQQWQNATIHFASSSSVMAPFFANQSCDPFQPRIRPCELGNYVSYAIAAETTSDVQNAIAFARANHIRLVIRNTGHDYLGRSTGAGALGVWTHHLKNIEFVDWDDDTYTGNAVKLGAGVQGFEVLEAARSRGLVVVGGECPTVGIAGGYSQGGGHSALSTSFGLSVDNVLSWEVITAKGELLTVNKDENPDLFWALRGGGGGTFGVVISMTVKAHPGTITSGASLSFSTDTNSEEAFWAGIQVFQDTLEDMVDAGTMVIHIITNTSFLIAPLTAYNKTEAQVKVIMKPFISSLTSKHVDFDVTYKESKTYYDHYNEFLGPLPYGKIRVGFEQYGGRLIPRSVVPNFTETLRQVTNMGVTWVGVATDVGPFGTRATTSVHPAWRSTLVHALLSTPWDFTKPWHDMIKLQDLMTNVIMPKVEAVTPGSGAYVNEADFRQPNYQDVFWGDNYKDLLEVKEKWDPEHFFFVPKGVGSEIWSIAEDGRMCKSAL
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals (PubMed:16262793, PubMed:16517624, PubMed:18427109).  The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules (PubMed:16262793, PubMed:16517624, PubMed:18427109).  The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation (PubMed:16262793, PubMed:16517624, PubMed:16751498, PubMed:18427109).  The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide (PubMed:16262793, PubMed:16517624, PubMed:18427109).  ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis (PubMed:18427109).  ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone (PubMed:18427109).  ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway (PubMed:16262793).
What are the official names of this protein?
FAD-linked oxidoreductase ZEB1, Zearalenone biosynthesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: RPOC2_STAPU
Sequence: MARLTAEFGDRIYYNQVMDRGAMRQLIGRLIIYLGSNCTSQILDQLKTLGFRHATQAGISLGVDDLITTPSKTWLIRDAEYQAYTSEEQYRRGSIHAVEKLRHVVETWHTTSEYLKREMTSHFRITDPLNPVHIMSFSGARGNVSQVHQLVGMRGLMANPQGNIIDLPIQSNLREGLSLTEYIISCYGARKGVVDTAVRTADAGYLTRRLVEVVQHVVIRNPDCETNQGIRLHSIRDRKTTRDAGGNSLLSLQERLIGRVLARNVFLGKRCIAIKNQDLAPDLVNSLVNFPKALLSPGSEGGHCEILVRSPLTCKSMPRACQKCYGWDLSCGNLVEIGAAIGIVAGQSIGEPGTQLTLRTFHTGGVFTGGVAEHVRAPFNGIVHFSISSSTHKTKTIQPTRNRHGRPAWTCPEAFSVIIEDRIGKKKVLNVPQYSLLLVKNHQYVQSRQIIAEVRASIAPLKEKIEKNIYSHLQGEVFYNPIGLRASCLKQRHFLHFLCSASRMNLWIEFASIRSYLSPLVEKTSYIWIFSGRLNKFFNATLNLSFFYQTQDYIQRDLPIGIQNHVFNYSKVFLLSIYNRQRSVTFSVSRRDIRLGRKKKFTDYIPLSRISTDKIFSKHTGSIHTISEQNEWILTLSFVDQFSKKMFSSVQTPGTSKVSEKSEEQIIDFQEQLILNYPLSKTTIFLKEPSILAKNYSIAEKDSCIGLLGEFFIFLNELSIVSVRTFISTSQINLFLKKNVFSLLCITHGNTFKGKEKIFFINDSKNIYNIKNWLISVNFLIWCHFSNRILNKNQTLATIFLSNRSLRNEKDLQVKEFKIGQSICPSRDLGEKIFEPFTHSILPESGHLLSLNEGNLLIRLAKLYLIPTGGIAHTFHKQTINEGDTLVTLAYERLKASDIIQGLPKAEQLLEARVGNQVVINLYMRFEILVARIKEQLRNYIGSLTQMDLMLSQISVNRASKALEYSQLETVDQVQKVYLSQGVYISDKHFEVIVRQMSSKIAIVENTDFTAFSPKAVIRTAFPYDVLGVFFPGEILDISKAQKMNRVLYKPLPCKPVLLGITQASLNANSFLSEASFERTITVLSRSALQGRMDWLKGLKENVLLSKMIPAGTGLKQAPVLLSPNGTGTLFSNNEQNIFQKKNVTSLSKSKGQKVQIRKIFSFQKSPQRLSFLYQETSSSNIRRKIQPTVCLCKPFITKRNWLHISLKQLTEQSLNYETKKFCLQELTNNFIPRKKENIFYLKKKTIKTT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta'', PEP, Plastid-encoded RNA polymerase subunit beta'', RNA polymerase subunit beta''.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: UNG_SHV21
Sequence: MDNWLKQEIWSKTQHQDITSDDCLLLSTDWVEFLQMSQFLKQKLLQLLNCIKEKRKKAVIYPPDNKIMFWSYCCAPRDIKVVILGQDPYHGGQGTGLAFSVSYEHSIPPSLKNIFFELQRSDPLFHAPNHGCLNSWATQGVLLLNTVLTVEKGKAYSHSDLGWQWFTNYIISSVSEKLSNCVFMLWGTKAIEKSILIDSSKHLVLKAQHPSPLAAASQRVGTWPKFIGCDHFNQANKYLEEHKKKPISWALL
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines.  Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG, UNG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: RL3_MESFL
Sequence: MKGILGRKVEMTQVFTANGKLVPVTVVEVQPNTILQVKTLETNGYVATQLGVFDKRENLVNKPELGQFKKANSVPKRFVKEIRNMEGFEVGSVISASDIFETGQYVDVTGISKGKGFAGAIKRHNYSRGPMAHGSGYHRGIGSMGAIINRIFKSKKMAGHMGHVKRTVQNLEVIAIDNNIMLVKGSIPGPNKGFVTIKANVKGLSNTQAAELLVRNAPVATEAPIEAPVVEEVVSTEE
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: TCTP_SCHPO
Sequence: MLLYKDVISGDELVSDAYDLKEVDDIVYEADCQMVTVKQGGDVDIGANPSAEDAEENAEEGTETVNNLVYSFRLSPTSFDKKSYMSYIKGYMKAIKARLQESNPERVPVFEKNAIGFVKKILANFKDYDFYIGESMDPDAMVVLMNYREDGITPYMIFFKDGLVSEKF
What is the function of this protein?
Involved in calcium binding and microtubule stabilization (By similarity).  May be a guanine nucleotide-free chaperone (GFC).
What are the official names of this protein?
Translationally-controlled tumor protein homolog, TCTP, p23fyp.
What is the protein family that this protein belongs to?
Belongs to the TCTP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUR8_MOUSE
Sequence: MSDNKKPDKAHSGSGGDGDGNRCNLLHRYSLEEILPYLGWLVFAVVTTSFLALQMFIDALYEEQYERDVAWIARQSKRMSSVDEDEDDEDDEDDYYDDEDDDDDAFYDDEDDEEEELENLMDDESEDEAEEEMSVEMGAGAEEMGAGANCACVPGHHLRKNEVKCRMIYFFHDPNFLVSIPVNPKEQMECRCENADEEVAMEEEEEEEEEEEEEEMGNPDGFSP
What are the official names of this protein?
Tumor rejection antigen P815A.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL5_LACPL
Sequence: MENRLKAQYEKEIVPALVDKFNYTSVMQVPKLAKIVLNMGVGDAVTNAKNLDEAVEELTLISGQKPLVTRAKKSIAGFRLREGMAIGAKVDLRGERMYDFLDKLINVSLPRVRDFHGVSTRSFDGRGNYTLGVREQLIFPEINYDNVNRVRGLDIVIVTTADSDEESRELLTQFGMPFAK
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: DCUP_STAAR
Sequence: MVHNKNNTILKMIKGEETTHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPVILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLGHGVFPEVQPETLRKVSGFVHTYTQR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_THIDA
Sequence: MPRRREVPKREILPDPKFGNQEVSKFMNVVMSSGKKSVAERIVYGAFEQITTKSGKDPLEVFSTALNNARPLVEVKSRRVGGANYQVPVEVRSSRRTALAMRWLKDAARKRGEKSMGARLAGELLDAAEGRGGAVKKREEVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ASNA_STRT1
Sequence: MKKSFIDQQKEISFVKNTFTQYLIDKLDVVEVQGPILSKVGDGMQDNLNGIENPVTVNVLQIPDATYEVVHSLAKWKRHTLARFGFNEGEGLVVNMKALRPDEDSLDATHSVYVDQWDWEKVIPDGHRNIAYLKETVETIYKVIRLTELAVEARYDIEAVLPKKITFIHSEELVEKYPDLTPKERENAITKEYGAVFLIGIGGVLPDGKPHDGRAPDYDDWTTESEKGYHGLNGDILVWNEQLGHAFELSSMGIRVDEDALKRQVEITGDQDRLKLDWHQALLHGQFPLTIGGGIGQSRMAMFLLRKKHIGEVQTSVWPDAVRETYENIL
What are the official names of this protein?
Aspartate--ammonia ligase, Asparagine synthetase A.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B3GN3_MOUSE
Sequence: MRLPRQSPYEILLLVLVALLVLLLLLTSKSPPSCSAPERSKEPEDNPGWATGHPRTHPARCRANLSVSSHPDFAGLPLHVRDFLFYRHCRDFPVLREPRVTKCAEPVFLLLAIKSSPANYGRRQMLRTTWARERRVRGAPLRRLFLVGSDRDPQQARKYNRLLELEAQKYGDILQWDFHDSFFNLTLKQVLFLEWQLTYCTNASFVLNGDDDVFAHTDNMVTYLQDHDPDQHLFVGHLIQNVGPIRVPWSKYFIPALVMAEDRYPPYCGGGGFLLSRFTVAALRRAARVLPMFPIDDVFLGMCLQQQGLAPGTHSGVRTAGVFPPSPRVSSFDPCFYRDLLLVHRFLPFEMLLMWDALNQPQLLCGRQSPAY
What is the function of this protein?
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine.  Has activity for type 2 oligosaccharides.  Also acts as a core1-1,3-N-acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans.
What are the official names of this protein?
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3, Core 1 extending beta-1,3-N-acetylglucosaminyltransferase, Core1-beta3GlcNAcT, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, BGnT-3, Beta-1,3-Gn-T3, Beta-1,3-N-acetylglucosaminyltransferase 3, Beta3Gn-T3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 31 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: Y1464_AQUAE
Sequence: MMEVRINKFLSEAGVASRRKAEKLILEGRVKVNGEVVRSLGVKVNPEVDIVEVDGKPVKPQRKRYIILNKPCCYLTQLGRSPDGRKTIEELIKDIPERVFPVGRLDYNTEGLLILTNDGELANRILHPRYKLPKVYLALVEGKVDQKTLKRMKQGIELEDGFAKPDNIRIVRYEGKNTLLEITFHEGRKHLVKRFLGAFGHKVKRLKRIAIGPIKLGKLSPGKWRELNQGELAQLFKAVGLKYVPRKRR
What are the official names of this protein?
Uncharacterized RNA pseudouridine synthase aq_1464, RNA pseudouridylate synthase, RNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase RsuA family.
Protein: IF3_GLOVI
Sequence: MLWLALFFGRFSRLEAPQRLVIKKRSDRGQANLPMINERIRFPKIRAIDADGTQLGIMHPRDALRIAEERNLDLVVVSEDAQPPVCRIMDYGKYKFEQEKRAKEARKKQHTADVKEVKMRYTIGEHDYQVRLRDTIRFLKDGDKVKATIMFRGREIQHANLAKDLLMQLAADSAEIGEVQQEPSVEGRNMIMILSPKRT
What is the function of this protein?
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
What are the official names of this protein?
Translation initiation factor IF-3.
What is the protein family that this protein belongs to?
Belongs to the IF-3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURB_ENTFA
Sequence: MNTKAMLETLNEITLLVDEPLKNVTFTKTGGPADVLALPKTKKEVEEIVAYCREQGLSWLVLGNASNLIVRDGGIRDVVIMLTEMKEIKVAGTTMIVDAGAKLIDTTYEALAADLTGFEFACGIPGSVGGAVYMNAGAYGGEIKDVFQSAEVLLADGTIQTMTKEDLNFRYRHSEIQELHCIVLQATFALEKGNHAEIKAQMDELTELRELKQPLEYPSCGSVFKRPVGHFTGKLIQDAGLQGLKWGGAQISEKHAGFIVNIDHATATDYVELIAHIQEVIKEKFDVELQTEVRIIGEEV
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE1_PSE14
Sequence: MKISRQAYADMFGPTVGDKVRLADTELWIEVEKDFTTYGEEVKFGGGKVIRDGMGQGQLMAADVVDTLITNALIIDHWGIVKADVGIKNGRIAAIGKAGNPDIQPDVTIAVGAATEVIAGEGMILTAGGVDTHIHFICPQQIEEALMSGVTTMIGGGTGPATGTNATTVTPGPWHMARMLQASDSFPMNIGFTGKGNVSLPGPLIEQVKAGAIGLKLHEDWGTTPAAIDNCLSVADEYDVQVAIHSDTLNESGFVETTLAAFKNRTIHTYHTEGAGGGHAPDIIKACGSPNVLPSSTNPTRPFTRNTIDEHLDMLMVCHHLDPSIAEDVAFAESRIRRETIAAEDILHDLGAFSMLSSDSQAMGRVGEVIMRTWQTADKMKKQRGPLPQDGPGNDNFRAKRYIAKYTINPAITHGISHEVGSIEVGKWADLVLWRPAFFGVKPTLILKGGAIAASLMGDANASIPTPQPVHYRPMFASYGSSLHATSLTFISQAAFDAGVPESLGLKKQIGVVKGCRTVQKKDLIHNDYLPDIEVDPQTYQVKADGVLLWCEPADVLPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HELS_PYRHO
Sequence: MKVEELRIDERIKEVLKKRGISELYPPQAEALTSGILKGENALIAIPTASGKTLIAEIAIVNRLLKEGGKAVYLVPLKALAEEKFKEFKDWEELGLKVAMATGDYDSKDEWLGGYDIIIATAEKFDSLLRHGSSWIRNVKVLVVDEIHLIGSRDRGATLEFIITQMLNRAQIIGLSATIGNPEELAEWLNAKLIKSDWRPVKLRRGVFYQGFVFWEDGKTEKFNSWEELVYDAIKRSKGSLVFVNMRRKAEKTALELSKKIRNFLTKKELRELKELAESLEENPTNEKLAKALQGGVAFHHAGLGREERVLVEENFKKGLIKVVVATPTLSAGINTPAFRVIVRDTWRYSEFGMERIPILEIQQMMGRAGRPKYDEVGEAIIVSTTEEPSTVMERYIKGKPEKLFSQLSNESILRGQILALIATFNFSSFREIYDFLERTFYAYQGKDPYTLEDRIRDIVYFLLENEFIEITLDDEIKALPLGIRTAKLYIDPMTAKIFKDTLPKIEKDPNPLGILHVISLTPDLIPLPYGKKELPMLEDEYYSFKDRLYFELDWEDERKFLRAFKTALVLNAWINEVPEGEIVEKFNVEPGDIYRIVETAEWLVYSLKEIAKTLEYSQDVINYLETLRVRVKHGIREELIPLMELPMIGRKRARALYNAGFRDLESIKNARPAELLEVEGIGAKIVEAILKHLGREVKIVQKPRKGTLDYYLHP
What is the function of this protein?
DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
What are the official names of this protein?
ATP-dependent DNA helicase Hel308.
What is the protein family that this protein belongs to?
Belongs to the helicase family. Hel308 subfamily.
Protein: COPT1_HUMAN
Sequence: MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITEHCH
What is the function of this protein?
Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells.
What are the official names of this protein?
High affinity copper uptake protein 1, Copper transporter 1, hCTR1, Solute carrier family 31 member 1.
What is the protein family that this protein belongs to?
Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells.
Protein: MOT1_MOUSE
Sequence: MPPAIGGPVGYTPPDGGWGWAVLVGAFISIGFSYAFPKSITVFFKEIEVIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYLCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFDIFDWRGSFLILGGLLLNCCVAGSLMRPIGPEQVKLEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTINKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSSYGKSKDFSSEKSAFLLSILAFVDMVARPSMGLAANTKWIRPRIQYFFAASVVANGVCHLLAPLSTTYVGFCVYAGVFGFAFGWLSSVLFETLMDLIGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGIYLFIGMGINYRLLAKEQKAEEKQKREGKEDEASTDVDEKPKETMKAAQSPQQHSSGDPTEEESPV
What is the function of this protein?
Bidirectional proton-coupled monocarboxylate transporter.  Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (By similarity).  The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate.  MCT1 is a major lactate exporter (By similarity).  Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (PubMed:22522610, PubMed:24367518).  Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart.  Functions via alternate outward- and inward-open conformation states.  Protonation and deprotonation of 302-Asp is essential for the conformational transition (By similarity).
What are the official names of this protein?
Monocarboxylate transporter 1, MCT 1, Solute carrier family 16 member 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS11_SERP5
Sequence: MAKAPVRTRKRVRKQVSDGVAHVHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ATG4_LODEL
Sequence: MSLMSDDSEVFVQAPTVANAELNIEAKPEANAQVNAEADSDANLGNNLGEQQTTDESAFGRNIGKFTAFVKEITGSGTEVEEQEKRNNHTISVDPSSNHENTSFEPTTYKILGRTYTSTTDASARVQELLWLSYRCGFEPIPKSDDGPQPITFFPSIVFNRLTLVNLSNLRSLLDKDHFTSDAGWGCMIRTSQNLLANALLRLFHTTGGQPQNFAVTKTEADVIELFQDTLSAPFSLHNFIKAANSLSLNIKPGQWFGPSAASLSIKKLVNDYNLIQQERRSERDSGRDSGHKVPTPNLKLHSKSADSDSDSDSDAISKRNSIPYVYVSENCDLYDDEINAIFELEQRPILFLFPIRLGIEQVNKYYYSSILQILASKFSVGIAGGKPSSSFYFIGYEGEDDLIYFDPHLPQIVQTPVNLESYHTSEYSKLKIDQLDPSMMIGILIETIDEYQEFKMSCFESDNKILHFHPLVTTAPRESSINQSWEEVQGEEEFVNLNIVKNEEDFVDLGSASTQGQNHEPS
What is the function of this protein?
Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine.  ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy.  The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.  In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components.  ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
What are the official names of this protein?
Probable cysteine protease ATG4, Autophagy-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase C54 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Preautophagosomal structure.
Protein: ARGR_THEP1
Sequence: MKISKKRRQELIRKIIHEKKISNQFQIVEELKKYGIKAVQPTVARDLKEIGAVKIMDESGNYVYKLLDETPVIDPWKELKRNFKSFVESIDRAGNLIVIKTIPGTASGIARVIDRLDIDEIVGTLAGDDTIFVAVRDPESCEKIVEKLSSIL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_VIBA3
Sequence: MARYLGPKLKLSRREGTDLFLKSGVRAIDTKCKIDNAPGVHGARRGRLSEYGVQLREKQKVRRIYGVLEKQFRNYYKEAARLKGNTGANLLQLLEGRLDNVVYRMGFGATRAESRQLVSHKSILVNGKVVNVPSFKVAANDVVSIREKAKQQSRIKAALEVAEQREKPTWIEVDAGKMEGTFKRMPERSDLSADINEHLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: TXE02_LYCSI
Sequence: MNSKVFAALLLLALSTCVLSEKYCPTPRNTSCKKMNIRNNCCRDSDCTSNAFCCAEPCGNFCHKASDKPGGRRVDPNASCQTGYVYW
What is the function of this protein?
Has antibacterial activity.
What are the official names of this protein?
U14-lycotoxin-Ls1a, Toxin-like structure LSTX-N2.
What is the protein family that this protein belongs to?
Belongs to the venom protein 11 family. 01 (wap-1) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LEC_LENCT
Sequence: MASLQTQMISFYLIFLSILLTTIFFFKVNSTETTSFSITKFSPDQQNLIFQGDGYTTKGKLTLTKAVKSTVGRALYSTPIHIWDRDTGSVANFVTSFTFVIDAPSSYNVADGFTFFIAPVDTKPQTGGGYLGVFNSKEYDKTSQTVAVEFDTFYNAAWDPSNKERHIGIDVNSIKSVNTKSWNLQNGERANVVIAFNAATNVLTVTLTYPNSLEEENVTSYTLNEVVPLKDVVPEWVRIGFSATTGAEFAAHEVHSWSFHSELGGTSSSKQAADA
What is the function of this protein?
D-mannose specific lectin.
What are the official names of this protein?
Lectin.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: RS4_FRAAA
Sequence: MARYTGADCKRCRREKTKLFLKGSKCDTPKCPIEIRPYPPGEHGRGRTKDSEYLLQKREKQKCARIYGILEKQFRGYYDEANRRAGKTGDELLKILESRLDNVVYRGGFAPSRDAARQAVRHGHVQVNGRKVDIPSYRISENDIVEIAPKARELTPFIVARETAGQGRAVPAWLESIPSQMRILVHSLPARQVIDTQVQEQLIVELYSK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: TSAC_MANSM
Sequence: MELAQIVERLKKNEVVAYPTEAVFGLGCNPNSKSAVEKLLILKQRPVEKGLILVAHKLDLLLPFIDESRLKQSHWQLLTQQYDCPTTWVVPAKLSVPKFITGQFDSVAVRLCTHPAVAQLCEQTGFALTSTSANLSGLPPCKTAQQVRSQFGEFFPVLDMAVGNAVNPSEIRDIFSRQIFRRG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.