PharMolix/UniProtQA huggingface dataset:
Protein: DCTN2_DANRE
Sequence: MADPKYANLPGIASNEPDVYETSDLPEDDQAQFESELEELCSDSVERIVVNPNAAYDKFKDKHVSAKSLDFSDRISKNRRVGYESGDYELLAEGCGVKETPQQKYQRLVNEIHELCQDVEKIQTSTKESGAEERLTPVALAQQAAQLKQQLVSAHLDSLLGPDAHINLTDPDGALAKRLLTQLEVARGVRSGAGADGKTAAPKGPDGVILYELHSRPEQEKFTESAKVAELERRLAELETAVGSGSDKRGPLSSGVQGSSLTETLELLQARVSALDAATLDQVEARLQSVLGKMNEIAKHKATMEDAETQSKVSQLYDVVQKWDAMATSLPQVVRRLTAVRELHEQAMQFGQLLTHLDTTQQMINNSLKDNSTLLTQVQQTMKENLLAVEENFSALDQRMKKLNK
What is the function of this protein?
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.  In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity).  Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.  Involved in anchoring microtubules to centrosomes (By similarity).
What are the official names of this protein?
Dynactin subunit 2.
What is the protein family that this protein belongs to?
Belongs to the dynactin subunit 2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
Protein: DUS3_SCLS1
Sequence: MTDEIPNPVQPEKSLKRPLDGEQLEEAHPPQPILPEDSAVTKAEKVERNGANGNSVSNEEPVAKRIKTEEQNHNSTATDSRDRVRGIAPIKAEYLLHPAGSRSATDGRNPAANDDAAEEKPRGDNRDNGGKKKKKEKGQNKDRQFGSWGDKIKLCNSTSNSPEFSPKECSFGESCKCEHDLRKYLAEGKRGDLTTFNSKCPVWEDNGTCLAGWKCRFVGSHSKEVKREDGRMELVLIEDLERMRTTVAGDEEALGGVVNVVSTKDKLDLARRRTKMEKSDLYTNWLDKNSEEVNRQSNLRKDQKNDQTQEEKEENRARYVEPPFLPSEKRRIYFGPETPVLAPLTTQGNLPFRRLCVELGAQLTYSEMAMSIPLFQGQKSEWALMKAHESEITPPRINPDRSSIVQNYNNSKDLKFGTQISANKPFQAIKAAEILSRFVPHLRVIDLNCGCPIELVYRQGAGSALLDAPSKLEKMIRGMNAVSGEVPITAKIRMGTMTGKPTALKTIERLAFGGVESRERLGAPGCAAITLHGRSRQQRYTKNADWSYIAECAALVKSYNQKKDDLTDTIMEPDARTLPNAPDGKLHFIGNGDCYSHVDYLDHIQNASVDSVMVARGALIKPWLFEEIEKGQTLDKSASERLQYIEKFARYGLEAWGSDEMGVGQTRRFLLEWLSFAHRYVPAGILEHLPPSLQDRPPAYRGRNDLETLLASDNYMDWMKICEMFLGPAHEGFKFQPKHKSNSYEIEAEG
What is the function of this protein?
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.  Specifically modifies U47 in cytoplasmic tRNAs (By similarity).  Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
What are the official names of this protein?
tRNA-dihydrouridine(47) synthase [NAD(P)(+)], mRNA-dihydrouridine synthase dus3, tRNA-dihydrouridine synthase 3.
What is the protein family that this protein belongs to?
Belongs to the Dus family. Dus3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HXT4_YEAST
Sequence: MSEEAAYQEDTAVQNTPADALSPVESDSNSALSTPSNKAERDDMKDFDENHEESNNYVEIPKKPASAYVTVSICCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKVSADDPAVMAEVEVVQATVEAEKLAGNASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDSFETSIVLGIVNFASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWPNGKKNGSSKGAGNCMIVFTCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAIDFYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEVNTLWEEGVLPWKSPSWVPPNKRGTDYNADDLMHDDQPFYKKMFGKK
What is the function of this protein?
Low-affinity glucose transporter.  Can also transport xylose.
What are the official names of this protein?
Low-affinity glucose transporter HXT4, Low-affinity glucose transporter LGT1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: METK_XANOP
Sequence: MSSYLFTSESVSEGHPDKIADQISDAVLDAILAQDKRARVACETMVKTGVAIVAGEVTTSAWIDLEALTRKVILDIGYNSSDVGFDGETCGVLNLIGKQSPDINQGVDRKNPEQQGAGDQGLMFGYATNETDSFMPAAIHLSHRLVEQQAKIRKKKNSALSWLRPDAKSQVTLRYEDGVATAIDAVVLSTQHDPGVKQKDLIEAVREEILKPVLPAKWLHKGTKFHINPTGKFVIGGPVGDCGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYVAKNVVAAGLADRCEVQVSYAIGVAEPTSISVTTFGTGKIADEQIEKLIRKHFDLRPFGIIQMLDLIHPMYQQTASYGHFGRKPKDFTYTDGTGAQHSATSFSWEKTDRADALRAAAKLK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_CAUVC
Sequence: MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVANSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRDLIADSVEYMVNAHCADAIVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVTVKGKIRALDLVDAMVVAADDSYSDEEVEAIEKAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSVLATHADREALFKEAGRVVVDLCQRWYEQEDATALPRGIATRAAFENAMSLDIAMGGSTNTVLHLLAAAHEGGIDFSMADIDRLSRHVPCLSKVAPAKSDVHMEDVHRAGGVMAILGELERGGLIDASQPTVHAPTMGEALARWDIGRTNSQIAHEFFKAAPGGKPTQVAFSQAARWEELDLDRENGVIRSVEHPFSKDGGLAVLFGNLAPEGCIVKTAGVDESILTFRGTARVFESQDAAVSGILGGQVKAGEVVVIRYEGPKGGPGMQEMLYPTTYLKSKGLGAACALVTDGRFSGGTSGLSIGHVSPEAGEGGLIALVETGDPILIDIPTRGITLEVSDAVLAARREAQLARGKDAWTPLNRKRDLTPALRAYAAMTTNAARGAVRDVSQIERG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RL331_ACHLI
Sequence: MREKIILVCSECLSRNFTTTKNKQTSKERLEMNKFCPRCNKHTLHKESK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: PPAC_LISW6
Sequence: MTKTLVFGHKNPDTDTICSAISYAELKKAQGADIEAVRLGELNSETTFVLDYFQATAPRLVQTVANEVSEVALVDHNERQQSANDIDEVTVTAVVDHHRIANFETSDPLYYRAEPVGCTTTILLKMFRENEVEISKTVAGLMLSAIISDTLLFQSPTCTEEDKVAAEKLAVIADVDIQTYGMEMLKAGADVSKKTVAELLLDAKEFNMNGNKVEIAQINVVDVNDVLNRRSEVEALMTQNVVDKGLDLYLFVITNILTNDSIGISIGSKTSVVEEAYGIKFVENQAPLKGVVSRKKQVVPILTDTFAK
What are the official names of this protein?
Probable manganese-dependent inorganic pyrophosphatase, Pyrophosphate phospho-hydrolase, PPase.
What is the protein family that this protein belongs to?
Belongs to the PPase class C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_BUCCC
Sequence: MIYSYTEKKRIRENFGKQPKILDIPYLLSIQIDSFKKFIEPKKNNYQGLESAFQSIFPIRSYNGCAELQYVSYTLGKKLFDMYESKTRGTTYSVPLRVKLQLIIYEKDSKNTNVKHIKEQEVYMGELPLMTHNGTFIINGTERVVVSQLHRSPGVFFDSDKGKTHSSGKILYNARIIPYRGSWLDVEFDPKDHLFIRIDRRRKIPATVLLHALNFSTEKILKIFFKHDIFYIKNKNIYMYLIPKRLKGEIIPFEIIKNKKRYIKKGERITTEHIKKLKKKKIKTIQIPEEYLYGKTISKNYYHPKTKEILIKSNTTLTQDEFNKIKNFNNKKFYVLFTNNIDNGAYISETLKIDTTKDRLTALIEIYKIMRPGEPPTKEAAENLFNNLFFSQERYDLSPVGRMKFNKSLKRKEKKGSGILNKEDIIDVIKKLINIKNGKGEIDDIDHLSNRRVRSVGEMVENQFRIGLVRVERAVRERLSLSDLDTLMPQDIINAKPISSAIKEFFGSSQLSQFMDQNNPLAEITHKRRISALGIGGLTRERAGFEVRDVHPTHYGRVCPVETPEGPNIGLINSLSIYARTNQYGFLETPYRKVKNGTVTTKIKYLSAIEEGNYIIAQANTKINKFGKFYKKFVTCRYNGEFGLFKNKKVNYMDISTQQIVSVGASLIPFLEHDDANRALMGANMQRQAVPTIKSEKPLVGTGMERSVAIDSGVTIIAKRSGKIEYVDASRIVVRIKDEKIRTYESGIDIYNLTKYSRSNQNTCINQIPCINLNDSIKKGDVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILISEKVEREDKFTTIHIQELSCICRDTKLGIEEITSDIPNIGESALSKLDTSGIIYIGADVSSGDVLVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGTNGTVIDVQIFTRDGVKKDKRTIEIEEMLLKKAKKDLTEELKIFELNIINRINKILLTLKTKINCIVANSLNEYFKKKIKYPKKIKKKIHTLKIQYKQLQKKFKKKIKEKTKKIIQGDELAPGILKIVKIFLAVKRKIQPGDKMAGRHGNKGVVSKINPVEDMPYDNNGEPIDIVLNPLGVPSRMNLGQILETHLGLAAKGIGNIINRMLKTNKKIYKIRKFLQKVYNLGENINQKINLDNFSDIEILQLAKNLRIGLPIATPVFDGVNEKEIKKLLKMSNFSTSGQITLFDGRTGEKFERNVTVGYMYMLKLNHLVDDKMHARSTGSYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGASHTLQEMLTVKSDDVTGRTKMYKNIVSGKHNMEPGMPESFNVLVKEIRSLGINIELNNN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: Y062_SIFVH
Sequence: MISYKYGEKDKTLHVKIYVLIEHVPQKPSEEELRKVLPKILKDFANMVEQGKIKILDSDEWGIW
What are the official names of this protein?
Uncharacterized protein 62.
Protein: WIPF3_RAT
Sequence: MPVPPPPPPPLPPPPPPLGAPPPPPPPGPPISTDAPSLRKSDLKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGTSKEGGAAGSNARGGSTPPALGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPTKAISGPLPAPASPRLGNASDTHSSARPVPPRPSVPAPPPPTTPPPPPPPPPPPPPPPLPPASPIKAPSVSPPVPPTKGNPSAVPAPIPCVPPLPPPPPTPPPLPPASALSEKAVRPQLAPLHLPPIPPPLPLLPPYGYPALHSEPSSPAQDVREPPAPPPPPPPPPPPPPPPLPTYASCSPRAAVAPPPPPLPGSSNSGSETPPPLPPKSPSFQTQKALPTPPGAPGPQIILQKKRRGPGAGGGKLNPPPAPPARSPTTELSSKTQQPGGQLRNGGQHVIDDFESKFTFHSMEDFPPPDEYKPGQKIYPSKVPRSRTPGSWLQAEAAGQSSDDIKTRNSQLSLKALR
What is the function of this protein?
May have a role in spermatogenesis (By similarity).  May be a regulator of cytoskeletal organization.
What are the official names of this protein?
WAS/WASL-interacting protein family member 3, Corticosteroids and regional expression protein 16.
What is the protein family that this protein belongs to?
Belongs to the verprolin family.
Protein: TSAD_SYNP2
Sequence: MSIVLAIETSCDETAVAIVNNRKVLGNVVASQIDIHREFGGVVPEVASRHHLESINACIDTAFEQSGLSWSEIEAIATTCAPGLVGALLLGAAAGKTLAMIHNKPFIGVHHLEGHIYASYLSQPELEPPFLCLLVSGGHTSFIEVRGCGEYKLLGETRDDAAGEAFDKVARLLRVGYPGGPVIDRLAKTGDPQAFKLPEGRISLPGGGYHPYDCSFSGLKTAVLRLVQQFETQGKAVPVADIAASFQYTVAQALTKRAVRCAGDRQLQTIVVGGGVAANSGLRQILTAAAAEAGIQVYFPPLKFCTDNAAMIACAAAEHFQKGDRSRLDLPVASRLPITQVQTLYTPLVPLKGKS
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_LISW6
Sequence: MFKIMKDFTEQEKIIVLDFGSQYNQLITRRIREFGVYSELHPHTITVEEMKALNPTGIIFSGGPNSVYDKDAFRADERIFDMGIPILGICYGMQLMTTHFDGKVERAKDREYGKADIHVENPSRLFAGLPTDQVVWMSHGDLVVEEPAGFEVTATSPSCPIAGIADEERLLYGVQFHPEVRHSVYGNELLKNFALNVCGCKGDWTMENFSEVEIAKIQEIVGDKKVLLALSGGVDSSVVGVLIHKAIGDQLTCIFVDHGLLRKGEADQVMATLQGEFNMNIIKVDAKKRFMDKLAGVSDPEQKRKIIGNEFIYVFDDEANKLDGVEFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRALGTELGMPDAIVWRQPFPGPGLGIRVLGEITEEKLEIVRDSDYILREEIKKAGLEREIWQYFTALPNIRSVGVMGDGRTYDHTVVVRAVTSIDGMTADWARIPWDVLEKISVRIVNEVDHVNRVVYDITSKPPATVEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: HIS1_NATPD
Sequence: MRIAVPNKGRLHEPALELLERAGLHVQDGSDRKLYADTVDPEVSVLFARAADIPEYVADGAAALGITGLDQERESETDLVDLLDLEFGSCRLVLASPEDGGVSAPEELSGGTVATEFPKITERYFEELGVRPDIVEVSGATELTPHVDIADAIVDITSTGTTLRMNRLEVVDEVLESSVRLFADPAVADDPKVEQVTTAFRSVLDADGKRYLMMNVPEDSLDAVEAEIPGMGGPTVMDVAGQDTVAVHVVVDEREVFEVIPKLKAAGATDILVTEIERLVP
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRG1_CHICK
Sequence: MAVSRALALRLAYAAAGALMGFSAFFTWSLAPAFRQPATAAAGGLSGVLALWALITHVMYVQDYWRTWLKGLRFFLFIGILFSALSVVGFCTFLVLAITQHQSLTDPRSYYLSCVWSFISLKWAFLLSLYAYRYRNEFADISILSDF
What is the function of this protein?
Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
What are the official names of this protein?
Heme transporter HRG1, Heme-responsive gene 1 protein homolog, HRG-1, Solute carrier family 48 member 1.
What is the protein family that this protein belongs to?
Belongs to the HRG family.
What are the subcellular locations of this protein?
Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein.
Protein: TATB_MYCVP
Sequence: MFANVGWGEMLVLVIAGLVILGPERLPGAIRWTAGAVRQARDYVTGATSQLREELGTDFDDLREPLSELQRLRGMTPRAALTKHLLDGDDSIFTGKFDQNGKSEKPEQKPEKPQSAPGPAAAVPDQPAGGRSGSTPYDTDAT
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: YJ75_SCHPO
Sequence: MTMKISVWSLLIVIGYHLWMSPVLAGPLNFGYLSWGQHSILEQDSVQLISHQSLLPAGDNLISLHKSLVEIESLGGNEVNVSDFLKSYLESKGLTVELQRVSSNPTVRDNVYAYLGSQRNTKVVLTSHIDTVNPFLPYYIEGDKIHGRGSCDAKSSVAAQIFAMLELMSEGKVQEGDLSLLFVVGEEIDGIGMKTVANKLNADWEVAIFGEPTENKLGVGHKGNFRFDVYAHGKACHSGYPQEGFSAIEFLLRQCVKLMDTDLPKSKLLGPSTINIGTIEGGAAANILAAEAKAEVFIRVAEDIETIRDIAEDLFDTEHSEIKVIQYSPPQYLDYDIPGMDTVVLAYATDIPYLSDRKMKIYLFGPGSIREAHGPNEYVTFSQLFEGLNGYKRMVMYNLR
What are the official names of this protein?
Peptidase M20 domain-containing protein C757.05c.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
What are the subcellular locations of this protein?
Secreted.
Protein: ASNA_PLABA
Sequence: MSKAGSDVSSISCSLSLDSDSCEDEYYETNLNKLIENTSLNWIFVGGKGGVGKTTTSCSIAIQLAKKRESVLLLSTDPAHNTSDAFNQKFTNKPTLINSFDNLYCMEIDTTFSEDTAFKINKSDFFNSIIPELLQSFPGIDEALCFAELMQSIKNMKYSVIVFDTAPTGHTLRLLAFPDLLKKALGYLINLKEKLKGTLSMLQSLTNNEMEFEGMYDKINHLNTMSISIQENFQNPLKTTFVCVCIPEFLSVYETERLIQELTKKNISCYNIVVNQVVFPLTSPDVNIEKCEKLLKQIKDTNIQNSFNSLILKAKELEDVYISRRKLQSKYLTQIKNLYGNYFHIVCMPQLKTEIRGLDKISNFSEMLLQSKDIPIYST
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
What are the official names of this protein?
ATPase ASNA1 homolog, Arsenical pump-driving ATPase homolog, Arsenite-stimulated ATPase.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum.
Protein: GSPL_VIBCH
Sequence: MEGSVSEFLTVRLSSQKEADIPWLVWSAEQQEVIASGQVAGWEALHEIESYADQRSVVVLLAASDLILTSVEIPPGASRQLENMLPYLLEDEIAQDVEDVHFCVLSKGRETADVVGVDRLWLRACLDHLKACGFDVKRVLPDVLAIPRPEHGLAALQLGDEWLVRKSTTQGMAVDAQWLSLLAASDWVQNEGEYLPLQALTPLPELSLAETQEWRYEPSGLVMQLLTQEALTSKFNLLTGSFKLKSSWLRYWQIWRKVAIAAGLFVAVSISYSLFQAHQYEAQADAYRAESERIFRSIFPDKQKIPTVTYLKRQMSDEMARLSGGASVGSVLKWLSPLPEALKGVNLQLQSIKFDSNRSEIRLEATSRDFQSFEQARTQLEQYFAVEQGQLNKNGEQVFGVFVVKPK
What is the function of this protein?
Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Plays a role in the complex assembly and recruits EpsM resulting in a stable complex in the inner membrane.  Provides thus a link between the energy-providing EpsE protein in the cytoplasm and the rest of the T2SS machinery.
What are the official names of this protein?
Type II secretion system protein L, T2SS protein L, Cholera toxin secretion protein EpsL, General secretion pathway protein L.
What is the protein family that this protein belongs to?
Belongs to the GSP L family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RS20_PROMH
Sequence: MANIKSAKKRAVQSEKRRQHNASRRSMMRTYIKKVYAAVASGDKEAAQKAFNDMQPIVDRQATKGLIHKNKAARHKANLQAQIKAM
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: ENO_VIBVY
Sequence: MSKIVKVLGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKARFLGKGVLKAIEAVNGAIADALVGKDAKDQAAIDAIMIELDGTENKSKFGANAILAVSLANAKAAAASKGMPLYEHIAELNGTAGQFSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGAEVFHNLAKVLKSKGYNTAVGDEGGFAPNLKSNAEALEVIAEAVAAAGYVLGKDVTLAMDCAASEFFDKEAGIYNMKGEGKTFTSEEFNHYLAGLVEQFPIVSIEDGLDESDWAGFAHQTQLLGDKIQLVGDDLFVTNTKILAEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGERAPFNGLKEVKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: PLSB_MYCTU
Sequence: MTKPAADASAVLTAEDTLVLASTATPVEMELIMGWLGQQRARHPDSKFDILKLPPRNAPPAALTALVEQLEPGFASSPQSGEDRSIVPVRVIWLPPADRSRAGKVAALLPGRDPYHPSQRQQRRILRTDPRRARVVAGESAKVSELRQQWRDTTVAEHKRDFAQFVSRRALLALARAEYRILGPQYKSPRLVKPEMLASARFRAGLDRIPGATVEDAGKMLDELSTGWSQVSVDLVSVLGRLASRGFDPEFDYDEYQVAAMRAALEAHPAVLLFSHRSYIDGVVVPVAMQDNRLPPVHMFGGINLSFGLMGPLMRRSGMIFIRRNIGNDPLYKYVLKEYVGYVVEKRFNLSWSIEGTRSRTGKMLPPKLGLMSYVADAYLDGRSDDILLQGVSICFDQLHEITEYAAYARGAEKTPEGLRWLYNFIKAQGERNFGKIYVRFPEAVSMRQYLGAPHGELTQDPAAKRLALQKMSFEVAWRILQATPVTATGLVSALLLTTRGTALTLDQLHHTLQDSLDYLERKQSPVSTSALRLRSREGVRAAADALSNGHPVTRVDSGREPVWYIAPDDEHAAAFYRNSVIHAFLETSIVELALAHAKHAEGDRVAAFWAQAMRLRDLLKFDFYFADSTAFRANIAQEMAWHQDWEDHLGVGGNEIDAMLYAKRPLMSDAMLRVFFEAYEIVADVLRDAPPDIGPEELTELALGLGRQFVAQGRVRSSEPVSTLLFATARQVAVDQELIAPAADLAERRVAFRRELRNILRDFDYVEQIARNQFVACEFKARQGRDRI
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HRCA_CORJK
Sequence: MSSGTEHRRNQVLRAIVSDFIASHEPVGSKMLVDRHQLGVSSATIRNDMAVLEAEGYITQQHASSGRIPTVKGYRRFVDGINEVKPLSTPERRAILDFLEHGVDLEDVLRRSVQLLSQLTRQVAVVQMPDLRRGRVKHCELVKLGSHRILLVLITDTGRVDQRNVDLGQPISDDDLPRLRDLVNSAMVGRTLDDACTNIAALANEAKGNSMPEELRDVALVVTTVLVETLLERPNDRLILAGTPNLMRTSELSPVVEALEEQVVVLKLLNSVRDLQVQVSIGEENEDEELRGASVVSTGYGNANAVLGGMGVVGPTHLDYSGTISSVTAVAHYVSRILSEE
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: OYE_STRPG
Sequence: MKERFSPLFEPLTLPNGSQLDNRFVLSPMVTNSSTKDGYVTQDDVSYALRRAASAPLQITGAAYVDPYGQLFEYGFSVTKDADISGLKELAQAMKAKGAKAVLQLTHAGRFASHALTKYGFVYGPSYMQLRSPQPHEVKPLTGQQIEELIAAYAQATRRAIQAGFDGVEVSSAQRLLIQTFFSTFSNKRTDSYGCQTLFNRSKLTLAVLQAVQQVINQEAPDGFIFGFRATPEETRGNDIGYSIDEFLQLMDWVLNIAKLDYLAIASWGRHVFRNTVRSPGPYYGRRVNQVVRDYLRNKLPVMATGGMNTPDKAIEALAHADFIGVSTPFVVDPEFAHKIKEGCEESIHLRIRPADLKSLAIPQASFKDIVPLMDYGESLPKESRTLFRSLTHNYKEIK
What are the official names of this protein?
Uncharacterized oxidoreductase SpyM50865, SpyOYE.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
Protein: Y326_METJA
Sequence: MIMKFVEKYFEFEKYGTNLKVETLAGITTFMTMAYIIFVNPQILSTAGMDFGAVMVATCIASAIATLVMGLYARYPFALAPGMGLNAYFTYGVCLGMGIDWRVALGAVFISGVLFIILTLTKIRTWIFNVIPNAIKYGTAVGIGLFIAFIGLKSAGIIVSSKATLVTLGNLMEPSTLLALFGIFLTSILVSRNVIGAILIGIIVTSLIGMILGISPFPEGIFSMPPSIAPTFLQLDIMGALNLGLLTIVLAFFFVDMFDTLGTLSALASQAGYLDKDGKLPRVEKALMADATGTVVGSLLGTSTVTTYIESASGIALGGRTGFVSVVVAMLFLLSLFFYPVVKAIPPYATAAALVIVGALMMRSVKYIDFDDYTEAIPAFITLLTIPLTFSIATGLALGFITYPILKVFTGRWKEVHWLVYVLAVIFALRFVYLSG
What are the official names of this protein?
Putative permease MJ0326.
What is the protein family that this protein belongs to?
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNLJ_MYCVP
Sequence: MSSKATQDPEAVLAEQSDDATEAGLRRQWQELADEVRDHQFRYYVRDAPIITDAEFDAMLRRLEALEEAHPELRTPDSPTQLVGGAGFATDFTAAEHLERMLSLDNVFTPDELAAWAARIRTEIGADAQYLCELKIDGVALSLVYRDGRLERGATRGDGRTGEDVTLNARTIEDVPEKLTGTEEFPLPSVLEVRGEVFFRIADFEDLNAGLVAEGKPPFANPRNSAAGSLRQKNPAVTARRRLRMICHGLGHIEDAAGFPFRTLHDAYRALQAWGLPVSPHTAQVTGLDAVTERIAYWGEHRHDVEHEIDGVVVKVDEVALQRRLGATSRAPRWAVAYKYPPEEAQTKLLDIRVNVGRTGRVTPFAYMEPVKIAGSTVGLATLHNGSEVKRKGVLIGDTVVIRKAGDVIPEVLGPVVDLRDGSEREFVMPTHCPECGTELAPAKEGDADIRCPNSRTCPAQLRERVFHVAGRGAFDIEGLGYEAAIALLQARVITDEGDLFTLTADDLLRTDLFTTKAGELSANGKRLLTNLGKAKAQPLWRVLVALSIRHVGPTAARALATEFGSLDAIVAASEEELAAVEGVGPTIAAAVTDWFTVDWHRTIVDKWRAAGVRMADERDASIERTLDGLSIVVTGSLTGYSRDEAKEAIIARGGKAAGSVSKKTAYVVAGDSPGSKYDKAIELGVPVLDEDGFRRLLENGPDTPDS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NRDR_ACIAC
Sequence: MKCPFCSHPETQVVETRVAEDGDFVRRRRQCGACDKRFTTYERPEVSFPNVVKKDGRRIEYDRSKLIGSFSIALRKRPVSTTQIDSAIERIEEKLLNLGQREVLSSRIGELVMRELKKLDKVAYIRFASVYRNFEDIDEFRALVDEVRK
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.