PharMolix/UniProtQA huggingface dataset:
Protein: I2B2_CONSR
Sequence: MMFRVTSVGCLLLVIVFLNLVVPTSACRAEGTYCENDSQCCLNECCWGGCGHPCRHPGKRSKLQEFFRQR
What is the function of this protein?
Modulator of potassium channels, specifically up-modulates the calcium and voltage-gated BK channels, has no effect on single channel conductance, but increases the open probability of BK channels.
What are the official names of this protein?
Kappa-conotoxin-like Sx11.2.
What is the protein family that this protein belongs to?
Belongs to the conotoxin I2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NDKA_DROME
Sequence: MAANKERTFIMVKPDGVQRGLVGKIIERFEQKGFKLVALKFTWASKELLEKHYADLSARPFFPGLVNYMNSGPVVPMVWEGLNVVKTGRQMLGATNPADSLPGTIRGDFCIQVGRNIIHGSDAVESAEKEIALWFNEKELVTWTPAAKDWIYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Abnormal wing disks protein, Killer of prune protein.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule- associated.
Protein: ARNT_PSEU2
Sequence: MIHVRHRHLALLLLAFVLAYLLPLGFHGLWIPDETRYAQISQEMLYSGNWIAPHFMGLRYFEKPAAGYWLIALGQQVFGENLFGVRIASALASGLSVLLAYLLAGKIWNDPRKQFASALLFMSFGFVAGQAGYANLDPQFTFWTNVTLLAFWYAVHSVGRARLAAWALVGVACGIGFMTKGFLAWALPVIIALPYMLCQRRLAELLRFGPLAVLIAIAVCLPWALAIHQQEPDYWRYFFWHEHIRRFAGDNAQHAQPWWFYMPLLVAACVPWALLLPATLQQAWQEKNRPDIAFLLLWLLLPLAFLSLSKGKLPTYILPCLLPLALLMANTLVERLDRGHSTALRANGIFNATVTFLGLVALIYLQLEQPVYENEPMHLSLAIIVLFGWTLANALQGLRPLTCWATPALGSWLLIALLPAALPNDVINNKTPDPFVVRHQAELAGCTQLLSNDLGAASALAWRLKRPDVALFNTWGELEYGLGYPDVQGREVRLQDIDAWMKNARSQGRVGVIMRGKSDEELKELESLPRDGQRYDEGNLAILVYEKSAS
What is the function of this protein?
Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase, 4-amino-4-deoxy-L-arabinose lipid A transferase, Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, Undecaprenyl phosphate-alpha-L-Ara4N transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 83 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILEUB_MOUSE
Sequence: MEQLSSANTLFTLELFHTLKESSPTGNIFFSPFSISSSLAMVFLGAKGSTAAQLSKTLHFDSVEDIHSCFQSLTAEVSKLGASHTLKLANRLYGEKTYNFLPEFLASTQKMYSADLAAVDFQHASEDARKEINQWVKGQTEGKIPELLAKGVVDSMTKLVLVNAIYFKGIWEEQFMTRETINAPFRLNKKDTKTVKMMYQKKKFPFGYISDLKCKVLEMPYQGGELSMVILLPEDIEDESTGLKKIEEQLTLGKLHEWTKHENLRNIDVHVKLPRFKMEESYILNSNLCCLGVQDLFSSGKADLSGMSGSRDLFVSKIVHKSFVDVNEQGTEAAAATGGIIQVLCEKMPTPQEVFTVDHPFLFFIRHNPTANMIFFGRVCSP
What is the function of this protein?
Regulates the activity of the neutrophil proteases.  Forms only a stable complex with CTSG/Cathepsin G (PubMed:12189154).  During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621).
What are the official names of this protein?
Leukocyte elastase inhibitor B, Serine protease inhibitor EIB, Serpin B1b.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VCL1_PEA
Sequence: DRRQELSNENVLVKVSRRQLEELSKNAKSSSRRSVSSESGPFNLRSEDPLYSNNSGKFFELTPEKNQQLQDLDLFVNSVDLKEGSLLLPNYNSRALLVLVLVVNEGKGDFELVGQRNENQGKEN
What is the function of this protein?
Seed storage protein.
What are the official names of this protein?
Vicilin, 14 kDa component.
What is the protein family that this protein belongs to?
Belongs to the 7S seed storage protein family.
What are the subcellular locations of this protein?
Vacuole, aleurone grain. Vacuole. Note=Cotyledonary membrane-bound vacuolar protein bodies.
Protein: RS9_STRE4
Sequence: MAQAQYAGTGRRKNAVARVRLVPGTGKITVNKKDVEEYIPHADLRLVINQPFAVTSTEGSYDVFVNVVGGGYAGQSGAIRHGIARALLQVDPDFRDSLKRAGLLTRDARMVERKKPGLKKARKASQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: OTCC_STRGC
Sequence: MTNSVFQGRSFLAEKDFTRAELEYLIGLSAHLKDLKKRNIEHRYLAGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVQENFGRLEGLTLVYCGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEQEIVELAEGFAKESGAHILITEDADEAVKGADVLYTDVWVSMGEEDKFAERVALLKPYQVNMDLVKKADNEDLIFLHCLPAFHDTNTVYGKDVAEKFGVEEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLYIPKV
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, catabolic, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LDRP_THET2
Sequence: MKRFARKETIYLRGEEARTLYRLEEGLVRVVELLPDGRLITLRHVLPGDYFGEEALEGKAYRYTAEAMTEAVVQGLDPRAMDHEALHRVARNLARQMRRVQAYEAHLQTGELRARIARYLLFLADTPLSARDRQGIYVTVSHEEIADATASIRESVSKVLADLRREGLIATAYRRVYLLDLAALEREAGSALEAA
What is the function of this protein?
Activates transcription.  Positively regulates PcrtB promoter upstream of the crtB operon in a cAMP-independent manner.  Regulated genes include genes encoding DNA photolyase, phytoene synthase and cytochrome P450 monooxygenase, which are involved in carotenoid biosynthesis (PubMed:21421762).  Positively regulates the light-inducible gene cluster in the megaplasmid in a cAMP-independent manner (PubMed:25294106).
What are the official names of this protein?
Transcriptional regulator LdrP, Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein LdrP, CRP/FNR superfamily protein LdrP, Light induced transcription regulator-dependent regulatory protein, LitR-dependent regulatory protein, LdrP.
Protein: VKOR1_BOVIN
Sequence: MGATWRSPGWVRLALCLAGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGKDSILNQSNSIFGCIFYTLQLLLGCLQGRWASVLLRLSCLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVGLTVLSFREVQGPQGKVKGH
What is the function of this protein?
Involved in vitamin K metabolism.  Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.  Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
What are the official names of this protein?
Vitamin K epoxide reductase complex subunit 1, Vitamin K1 2,3-epoxide reductase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the VKOR family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: YGGT_ECOLI
Sequence: MNTLTFLLSTVIELYTMVLLLRIWMQWAHCDFYNPFSQFVVKVTQPIIGPLRRVIPAMGPIDSASLLVAYILSFIKAIVLFKVVTFLPIIWIAGLLILLKTIGLLIFWVLLVMAIMSWVSQGRSPIEYVLIQLADPLLRPIRRLLPAMGGIDFSPMILVLLLYVINMGVAEVLQATGNMLLPGLWMAL
What are the official names of this protein?
Uncharacterized protein YggT.
What is the protein family that this protein belongs to?
Belongs to the YggT family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: INT3_ANOGA
Sequence: MDASGKGAAGFEGKLFVQTIDARDENEEKYMRAYRAFEETTAGLSDKDFHDLLSSLVSKEKQHEEISLALVYIILTDPSSAPKTYRDLTLLTRDGLGFVTANLAMLVAEKYHKLTDVGRKQLLWLLRELIKNQVLNVDNLAWNILRQASGGDISPKNVALIEGLLDIFTEHRAWLEKDQFLVGTVAYTFVRLIEDHFGPQFVHLRNREVKFVISLIRDRFMDIIPLGREFVRLLQNVGRIPEFDQLWKDMLYNPKSLCPTFNGVWQLLQTRTSRRFLRGRLTPDIERKIHFLTSNVKFGNQKRYQDWFQERYFNTPESQSLRCDLIRFIISAIHPTNDMLCSDIIPRWAIIGWLLTSCTNAVTLANAKLALFYDWLFFDPAKDNIMNVEPGILVMYHSIKNHPLVSCTLLDFLCRIMKNFYPKWEDRIRTGIYNSLRKILEMKVIPNLVPLFESPKLDRELKGMLRETFREFCVPPNSMYMHPGPPQPGMETPMMMHYPGPGGGEQVEQHPPHLMHPAAKAASTAASADDPKFSDDEDDATTKPATTTTTTTTTTKTEDVSDDDDLPLAKVRLLEKPAIAKVALPDTLNGHLEEFLREKSVKTFEPLLQCLGSCGKAALNQEQENYLTESVISVIKQTLPDKSYFPASKTDDNLSESINYPLFAAYRLLYQQEDSCKKRVMALLVAIVTRVSVAGYMLLYFLKVHGKLQGRRKETAGGSTAFKASVYGVLCDALDSVDSVDECIEKDLNLLEKHNTQMFLWILPDMYREFKQTMLNNTTVLRLLVGCIDANNLGDIIYSITQGKLILFDEDGIVEILRKSLEYETFEQVCIWQLVQAHDIPLETFQEIIPELESGAHAEALTAILLLLRAEKPTTELVRLLLSRETESKHRGDPFVTSVLRYWCQEFEEKLSELIAALLTSKYPSNSPNKRKRPSKSAQQNTAPTSEQLLNHLEHFRRSCRHGNGTGTGLFVQNDMQRALQQAFTHSSESQRKQFSDLFALAAEDETSTTVGRRGTSSRGRKAPSNKKETAAEKAAAAAAAAHANNSKKAAEASAKFSDDSSDEDWSKQKASKRRKTLSDSD
What are the official names of this protein?
Integrator complex subunit 3 homolog, SOSS complex subunit A homolog.
What is the protein family that this protein belongs to?
Belongs to the Integrator subunit 3 family.
Protein: RBL_CERS1
Sequence: MDTKTTEIKGKERYKAGVLKYAQMGYWDGDYVPKDTDVLALFRITPQEGVDPVEAAAAVAGESSTATWTVVWTDRLTACDSYRAKAYRVEPVPGTPGQYFCYVAYDLILFEEGSIANLTASIIGNVFSFKPLKAARLEDMRFPVAYVKTYKGPPTGIVGERERLDKFGKPLLGATTKPKLGLSGKNYGRVVYEGLKGGLDFMKDDENINSQPFMHWRDRFLYVMEAVNLASAQTGEVKGHYLNITAGTMEEMYRRAEFAKSLGSVIVMVDLIIGYTAIQSISEWCRQNDMILHMHRAGHGTYTRQKNHGISFRVIAKWLRLAGVDHLHCGTAVGKLEGDPLTVQGYYNVCREPFNTVDLPRGIFFEQDWADLRKVMPVASGGIHAGQMHQLLSLFGDDVVLQFGGGTIGHPMGIQAGATANRVALEAMVLARNEGRNIDVEGPEILRAAAKWCKPLEAALDTWGNITFNYTSTDTSDFVPTASVAM
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: RSMH_FRAT1
Sequence: MHYSVLLQESINDLNINPQGIYIDATFGRGGHSKAILNRLTTGRLIAFDKDLDAISYARENFQFSNFEIVHASFASIYDYCLQHSLLGKIDGIIMDLGVSSPQLDNAARGFSFTHNGPLDMRMDVSKGITASQALEELSVDDLSYIFKVYGEERFAKKIALRIKDYIQQNGSIRKTLELAELILATIGKKEKKNPATRCFQALRIYVNNELKDLEALLENILAVIKSGGRIAAISFHSLEDRIVKQKFSALINPKQELNRITKMLPQDSSQIKLKWITKKSKANEDELNQNVRSRSAILRVVEKL
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YI100_YEAST
Sequence: MLRSAPLALGLEPHPLNNSLAFPVFYHIHCYCPSPLLLSLLLHYTVLFSPFGARNHKLYIYIYIYIYIYIYMCINVCTYMNAGPRGVCSLCVYVCTHFNIYIHTYIYLLFVY
What are the official names of this protein?
Putative uncharacterized protein YIL100C-A.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SEPS_METM5
Sequence: MFKREEIIEMANKDFEKAWIETKDLIKAKKVNESYPRIKPAFGKTHPVNDTIENLRQAYLRMGFEEYINPVIVDERDIYKQFGPEAMAVLDRCFYLAGLPRPDVGLSDEKISQIEKLGIKVSEHKESLQKILHGYKKGTLDGDDLVLEISNALEISSEMGLKILEEVFPEFKDLTAVSSKLTLRSHMTSGWFLTVSDLMNKKPLPFKLFSIDRCFRREQKEDKSHLMTYHSASCAIAGEGVDINDGKAIAEGLLSQFGFTNFKFIPDEKKSKYYTPETQTEVYAYHPKLKEWLEVATFGVYSPVALSKYGIDVPVMNLGLGVERLAMISGNFADVREMVYPQFYEHKLSDRAVASMVKLDKVPVMDEIYDLTKELIDSCVKNKDLKSPCELTIEKTFSFGKTKKNVKINIFEKEEGKNLLGPSILNEIYVYDGNVIGIPESFDGVKEEFKDFLEKGKAEGVPTGIRYIDALCFKITSKLEEAFVSNTTEFKVKVPIVRSLSDINLKIDDIALKQIMSKTKVIDVRGPVFLNVEVKIE
What is the function of this protein?
Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
What are the official names of this protein?
O-phosphoserine--tRNA(Cys) ligase, O-phosphoserine--tRNA ligase, Non-canonical O-phosphoseryl-tRNA(Cys) synthetase, O-phosphoseryl-tRNA(Cys) synthetase, SepRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
Protein: NHAA_SALAR
Sequence: MKHLQRFFSSDASGGIILIIAAALAMLMANMGATSGWYHHFLETPVQLRVGALEINKNMLLWINDALMAVFFLLIGLEVKRELLQGSLASLRQAVFPVIAAIGGMIVPALLYLAFNYSDPVTREGWAIPAATDIAFALGVLALLGSRVPLALKIFLMALAIIDDLGAIIIIALFYTSDLSIVSLGVAAFAIVVLALLNLCGVRRTGVYILVGAILWTAVLKSGVHATLAGVIVGFFIPLKEKHGRSPAKRLEHILHPWVAYLILPLFAFANAGVSLQGVTIDGLTSMLPLGIIAGLLIGKPLGISLFCWLALRFKLAHLPQGTTYQQIMAVGILCGIGFTMSIFIASLAFGNVDPALINWAKLGILIGSLLSAVVGYSWLRARLNAPA
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: UCRIA_TRIV2
Sequence: MAQFSESVDVPDMGRRQFMNLLTFGTVTGVALGALYPVVNYFIPPATGGAGGGTTAKDELGNDVSVSKFLESHNVGDRTLVQGLKGDPTYIVVESKEAITDYGINAVCTHLGCVVPWNAAENKFKCPCHGSQYDATGKVVRGPAPKSLALSHAKTENDKIVLTPWTETDFRTGEEPWWS
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
What are the official names of this protein?
Cytochrome b6-f complex iron-sulfur subunit 1, Plastohydroquinone:plastocyanin oxidoreductase iron-sulfur protein, ISP, RISP, Rieske iron-sulfur protein.
What is the protein family that this protein belongs to?
Belongs to the Rieske iron-sulfur protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein. Note=The transmembrane helix obliquely spans the membrane in one monomer, and its extrinsic C-terminal domain is part of the other monomer.
Protein: HCP_SALDC
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDNFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLSVDANAHCDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECAMEIGQMNFKVMSILDAGETTKYGHPTPTQVNVKATEGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGSYDDRIWTRSIVGWPGVSHLEGDDFGPVIAQAQQMAGFPYSEIPHLITVGFGRQTLLGTADTLIDLVSREKLRHIFLVGGCDGARGERNYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFFTPDLLAILNEKFGLRSVTTVEEDMKQLLSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TX150_LYCSI
Sequence: MKFVLLFGVLLVTLFSYSSAEMLDDFDQADEDELLSLIEKEEARKDCIPKHYECTSNKHGCCRGHLFKYKCQCTTVVTQSGEETERCFCGTPPHHKAAELVVGFGKKIFG
What are the official names of this protein?
U1-lycotoxin-Ls1hh, Toxin-like structure LSTX-A50.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 03 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL16_BRUA1
Sequence: MMQPKRTKFRKQFKGRIHGNSKGGTDLNFGAFGLKALEPERVTARQIEAARRAITRHMKRAGRVWIRIFPDLPVTSKPTEVRMGKGKGSVDYWACRVAPGRVMFELDGVPEDVAREALRLGAAKLPIKTRFIQRIAE
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: PCDBE_PANTR
Sequence: MEIRGALDLRKRQVLIFLVLLGLSRAGTESAHYSVAEETEIGSFVANLARDLGLGVEELSSREARVVSDDNKKYLHLDLLTGNLLLNEKLDRDELCGSTEPCVLHFQVVLENPLQFFRVELRVKDINDHSPTFLDKEILIKISEGTTVGATFLMESAQDLDVGSNSLQNYTISPNSHFYIKIPDSSDRKIYPELVLDRALDYEQEAELRLTLTAVDGGSPPKSGTTLVLIKVLDINDNAPEFPQSLYEVQVPEDRPLGSWIATISAKDLDAGNYGKISYTFFHASEDIRKTFEINPISGEVNLRSPLDFEVIQSYTINIQATDGGGLSGKCTLLVKVMDINDNPPEVTISSITKRIPENASETLVALFSILDQDSGDNGRMICSIQDNLPFFLKPTFKNFFTLVSEKALDRESQAEYNITITVTDLGTPRLKTEYNITVLVSDVNDNAPAFTQTSYTLFLRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDPQLPLASLVSINADNGHLFALRSLDYEALQEFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNFQVHDTGKNMGEIENFRNSFGLNIQ
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin beta-14, PCDH-beta-14.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: Y3535_METJA
Sequence: MKIEQVKIENFRSIYDLTVEFGKVTVLIGKNSSGKTSILNVIRIIFENLDTNSTEKNLNITTITEQNLKDQIRRLWFYTYQNYPIKLAVWLNFDEGEGDKLREVCGLESNVKKAYIEVSIESNNNQIIWKLQNVIIFGYVSETSKIAKEALKKMKEIHSKVTGHNIESKTGDSLVPCVIVESGTIKNKDVFNIFIDLIKNKICYVNTFPEIYKMVNIPIKGLFAHPMVSSELINVIKNTIKDFARLRMLYDCLREIKGSVDTYEQPDRTEILTKSYEGMSLNYELFGSGDQIIDGILASIISKGKHHIFLIEEPEIHLHPAYIRRLARVLEDLANNLNVQLIIVTHSPDFIATLKDKRFVIGVRKDSIKINFEGYPTELLATRIFYPFRGSRLSESLARDLGVVPGYFLFSDVAILVEGNSDRIILQGYIDLLIEQLKNLPKFSYIIIPYAQRSLKEMIKVFKEDYGIKVFLIADNDEEGLKNVKIAKDMGLRENFEVFIIEKKDILGYIKPEDFILALDELLRECLKDKYEEVLQDEEIKSIIDEIKIFGACKNEEGKNEKDLLHKLSGKLFTVLKNVDEEFIITLGWDSGRSIERYLKCKIAEKIVSRLTEVPEDIKKIILNIDSELG
What are the official names of this protein?
Uncharacterized protein MJECL35.
Protein: ECFA2_MESH7
Sequence: MKIKAKNIVKIYDQKLPSELKALDKVTTEINQGEFIAIIGQTGSGKTTFIQHMNALLLPDQGEVEYLYFDSKNQEKKLVVQKPRFFRKKLKFINEIRRRVGVVFQFAEYQLFEQTIEKDIIFGAVSMGTPKNEAKKIAAEIIELVGLDQSFLQKSPFELSGGQKRRVAIAGILAMDPDIIFFDEPTAGLDPQGTLKMLEILDTLYKKGKTIILATHDLDSVLEWTKRCIFFKDGRIIYDGDTYSILANNKFLIENKMLPTNLLNFREKLIKIGYPISNVRSVSELISEINMLIQKETNAD
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: SYP_COREF
Sequence: MITRLSTLFLRTLREDPADAEVPSHKLLVRAGYIRRVAPGVYSWLPLGLRALRNIEQVVREEMDAIGGQELLFPGLLPREPYETTQRWTEYGDSLFRLKDRKGADYLLGPTHEEMFASTVKDLYSSYKDFPVTLYQIQTKYRDEERPRAGILRGREFVMKDSYSFDMTDAGLEESYARHRAAYQRIFDRLGIEYVICKATSGAMGGSASEEFLAVSANGEDTFVRATDGDFAANVEAVVTQPGQERPIEGLPEAVVHETPVSETIETLVAWANSIGVTVDGREVQASDTLKCIVVKTREPGAEEWELTGVLVPGDREVDMKRLEASLEPAEVELAVEADFAKYPFLVKGYVGPVGLARNGVRVLADPRVVTGTSWITGADEKERHVVGLVAGRDFTPDGFIEAAEIREGDPAPEGQGTLTLARGIEIGHIFQLGRKYTEAFDVQILDENGKRAIPTMGSYGIGVSRLLAVLAEQRHDEAGLNWSPAVAPYQVHVVAANKDAAAIEAAERYATELSQAGIDVLFDDRPKVSPGVKFKDAELLGMPFALILGRGYADGTVELRVRGGEKTELPVDEAVETIVRLVNEARG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VDTE1_BYSSP
Sequence: MASMQEVDALVVGAGFGGLWMTNRLKEAGLNVLCVEKAPQAGGVWYWNCYPGARVDSRYPVYQYSDESLCKDWNWSELFPGYEEIRKYLSYAVDKWQLNSHIRYNTTVTGARFDESDHKWTVEGINGSHGTIRIRCRWYILALGFASKPYIPDFEGLNRFQGPCFHSSAWPQEGIDLKGRRVAVVGTGASAVQIIQTISKEVGHLTVYQRTPCTAMPMRQQSLTPEYQDNFKASGEMAATMRRTKYERFGGQDVQFVSRRWHEDTPEQRRAVFEQAWQKGGFHLLLSTYFEVFDDVEVNHAAWRFWAEKSRERIHNTKYKDILAPLEAVHAFGGKRTPFEQDYFEAFNRRNVDLIDMKASPILSFAEKGIITQNEGLQEFDVIILATGFDTNTGALTSIHIQDTDGILLKDRWSYDGVMTTFGMSTSKFPNMFFFYGPQAPTAFSNGPSCIELQGEFVEELILDMIGKGVTRVDTTSEAEKRWKESTLSLWNQFVFSSTKGFYTGENIPGKKAEPLNWFGGFPRYRKALTECRDGGYKEYSLRSLPKVPDPEHRGLIDKVAVVTSAQPVGA
What is the function of this protein?
FAD-binding monooxygenase; part of the gene cluster that mediates the biosynthesis of viriditoxin, one of the 'classical' secondary metabolites produced by fungi and that has antibacterial activity (PubMed:31304040, PubMed:31045362).  The first step is performed by the polyketide synthase VdtA which condenses one acetyl-CoA and 6 malonyl-CoA units to form the heptaketide monomer backbone of viriditoxin (PubMed:31304040).  The product of VdtA is then O-methylated on C7 by the O-methyltransferase VdtC (PubMed:31304040, PubMed:31045362).  The O-methyl group is important for the stereoselective coupling of the monomers at the final step of viriditoxin biosynthesis (PubMed:31304040, PubMed:31045362).  The short-chain dehydrogenase/reductase VdtF then acts as a stereospecific reductase converting the pyrone to dihydropyrone via the reduction of the C3-C4 double bond (PubMed:31304040, PubMed:31045362).  The FAD-binding monooxygenase VdtE then converts the ketone group into a methyl-ester group to yield semi-viriditoxin (PubMed:31304040, PubMed:31045362).  Finally, the laccase VdtB is involved in dimerization of 2 semi-viriditoxin molecules to yield the final viriditoxin (PubMed:31304040, PubMed:31045362).  VdtB is responsible for the regioselective 6,6'-coupling of semi-viriditoxin, which yields (M)-viriditoxin and (P)-viriditoxin at a ratio of 1:2 (PubMed:31304040, PubMed:31045362).  The non-catalytic carboxylesterase-like protein VdtD affects the stereochemistical outcome of the coupling (PubMed:31304040, PubMed:31045362).  The highly reducing polyketide synthase VdtX is not involved in viriditoxin synthesis, but might possibly play a role in the production of additional metabolites not identified yet (PubMed:31304040, PubMed:31045362).
What are the official names of this protein?
FAD-binding monooxygenase VdtE, Viriditoxin biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding monooxygenase family.
Protein: TRMD_CHLCV
Sequence: MEIEILSLFPDYFDSPLRSSILGKAIKNGLLKIQSRDIRDFGLGKWKQVDDAPFNNDGMLLMAEPVVQAIRHIKRSDSRVIHLSPQGKPLTAQKSRELAKCSHLIFLCGHYEGIDERALESEVDEEISIGDYVLTNGGIAALVVIDALSRFIPGVLGNQESAEKDSLENGLLEGPQYTRPRVFEGKEVPEVLLQGDHQAVARWRKQVSLDRTRERRPDLYIRYLYDRENEEVFPREEDTKQSTLEGESAVVLEVEDLQRSRKFYSKMFRLNQPSKDKLQIPGRTQMVLHLQEVGLKNKNTAILSLRLDCEDDFFSFLGRWKMLGGTLEQADDHGTVRLVRDFDGHQWTISYKKVK
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.