PharMolix/UniProtQA huggingface dataset:
Protein: JANB_DROOR
Sequence: MKMFKSLSLLPRNVSPFQKCYSTDLISLVGVPRVKITKGQNRYLLVNIHTHGFTKYGRVIVRGADVDNHLTIFDSILEELEPQGICAKILGGGRILNEADSKKMKIYGTSRTFGSADHTRTRNILQSWTTYKDFKISVKN
What is the function of this protein?
JanA and janB regulate somatic sex differentiation.
What are the official names of this protein?
Sex-regulated protein janus-B.
What is the protein family that this protein belongs to?
Belongs to the janus family.
Protein: RECR_SYNWW
Sequence: MRLARPLENLIDQLLKLPGIGPKTAQRLALYILKLPEMEARQLAQAIVDCRQKVFPCSRCGYLTDFDPCLICSDESRDKSLICIGEESSDVIAIERTGFRGQYFVLNKDFNLMEDKGLEDLNLKPLEDRLATGEIKEVVLALNPDMDGEVMSRFLATVAGSFGVKVTRLAHGLPVGGDIEFADEITLRRALEGRKEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: DPO3_LACLA
Sequence: MENLFEKLMEQIKMPPNLRRSSQFEHADIENVEVHTASKLWHFQLIFDEILPIDTYKLLTELTETAFSTIARTEISVSSRNQNIDEQNLNDYYQYALTLPELCDSAFSSIFKKYHLEKEEEKIHLMVEDNPQMDFFVEKYFPILEEKFKSFGFGEVRITPLVDQELTETQAAAHAEKVAARLAAQTAEQAQISEIKKQRSEERESKNTREAKPEFVETALSDGIFFGRKISGQSPITSMSFIAGEGFGVIFEGLVFEAAHREFTGKESGKVNHILELKMADETSTFMISKWGRKDEEIAQFDQIVSTVKAMNEKIIADRTDGEDNFTDSLSDALWLRVQGNIEHDKYKDDLVLTANAVVEIKPKPTIDRVALQIKAVKSDKIQLGREIKNNEPVTPMRSVSEFSTNGPVVFEGYVFKGELREIKSRKTGNISYLLEFEMTDYTSSFYVQKWLRGEEEIQLAKQIKAGLWCRVRGNVQRDNFKNDLVLQLTDLIEIPTQNVREDKSDEKRVEFHAHTNMSQMDAIPSASSLVAQAAKWGHKAIAITDHGGLQSFPEAHSAGKKNGVKIIYGVEANLVEDKIPIVYNETDVDMYESTYVVFDVETTGLSAVHNDLIQIAATKMHKGNPIDEFDEFINPGYRLSEFTTELTGITDDHVKNAKPLYEVLTKFQKFCEGTILVAHNATFDVGFMNMNYSRNGLPIITQPVVDTLEFARNLYPEMKRFGLGQLTKKFQIGLEHHHMANFDAEATGRLLFVFLEELRTRNTGWTSLLELNDKLVSEDSYKKVRPKHVTLYAKTQEGLKNLFKIVSFGNVKYYAGLPRVPRSVLEANREGLLVGSACEIGEVFDAAINKTFEETLEIAKFYDFIEVFPPALYRSLVVGGSFKSEKELEQTLKDLIKIGKTLGKPVLATGNLHYLNPEDAIYREIIVRSLGLGAEINWTQGHGEHAKPLPLPEAHFRTTDEMLEAFSFLDEKTAREIVIDNTQKMADEFDVLTPVRDDLYTPKMVFDGGETSEERIVRLTYEKAHEWYGNPLPDIIDARLEKELRSILGNGFSVVYIISQELVKRSNDRGYIVGSRGSVGSSLVATMIGITEVNPLAPHYRCPECQYFECYDDGSFGSGYDMPDKNCPKCDHKLIKDGHDIPFETFLGFKGDKVPDIDLNFSGDDQPLAHLDVRDIFGEDYAFRAGTIGTVAEKTAFGFVKGYERDYDQFYGNAEIDRLAAGSTGVKRTTGQHPGGIIVIPNYMDVYDFSPVQFPADDVNAEWQTTHFDFHAIHDNILKLDILGHDDPTMIRKLQSLSGIVPQDIPMDDPGVMKLFTGTESLGLTEEQLGVKLGTLGIPEMGTFTSMNMIAEAKPKNFADLLQISGLSHGTDVWSGNAQDLIRSGIADLSSVIGCRDDIMVYLIHKGLENGLAFTIMERVRKGMWNKIPAEEREKYVEAMREHDVPEWYIESCSKIKYMFPKAHAAAYIMMALRVAYFKVHHPILYYCAWFSIRATAFDIGVMGAGLEAVKAKMKEIKDKGFDATNVETNLYTTLELCNEMLERGFTFGKIDLYRSEATEFVIDGDTLIPPFVTMDGLGENVAKQIVAARAEGEFLSKMELRKRGGVSQTIIENMTNMGVLEGMPDDNQLSLFDDFF
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2518_PECCP
Sequence: MLKKTLLSLTAVSMLASAGSALAAEYKFDKEGQHAFIEFRIKHLGYSWLYGSFNDFDGAFTFDEKNPSADKVNVTINTNSVDTNHAERDKHLRSAEFLNVTKHPQATFTSTEVKKDGEDYDITGNLTLNGVTKPVKLDAKLIGQGDDPWGNYRAGFQAEGTIKLKDFNITTDLGPASQEVELIIAVEGVRQK
What are the official names of this protein?
UPF0312 protein PC1_2518.
What is the protein family that this protein belongs to?
Belongs to the UPF0312 family. Type 1 subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: URE2_STAAN
Sequence: MIPGEIITKSTEVEINNHHPETVIEVENTGDRPIQVGSHFHFYEANAALDFEREMAYGKHLDIPAGAAVRFEPGDKKEVQLVEYAGKRKIFGFRGMVNGPIDESRVYRPTDENDAYAGVFGDNGAENVNKKGGKRS
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPP4_HUMAN
Sequence: MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
What is the function of this protein?
(Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2.
What are the official names of this protein?
Dipeptidyl peptidase 4, ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family. DPPIV subfamily.
Protein: FAR9_LUCCU
Sequence: SPSQDFMRF
What are the official names of this protein?
FMRFamide-9/10/11/12, LucFMRFamide-10, LucFMRFamide-11, LucFMRFamide-12, LucFMRFamide-9.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSD_SHEFN
Sequence: MDSIKIALQYMLPKHFLSRLVGKFAAAEAGAITTAVIKWFIKQYKIDMSEAQQPEPEAYKTFNAFFTRALKPELRPICQESNMMAHPVDGAVSQCGPIEAGNIFQAKGHSYTSEALLGGNKTDAARFDGGDFATIYLAPKDYHRLHMPITGTLSKMTYVPGDLFSVNPLTAQNVPGLFARNERVVAIFETEVGPLAMVLVGATIVASIETIWSGTVTPPGGKQVFSWDYPTTGPEAVTLEKGAEMGRFKLGSTVVMLFAQDAIETFADGVEPGETTRMGQPFARLKQQ
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GUX1_PENJA
Sequence: MKGSISYQIYKGALLLSALLNSVSAQQVGTLTAETHPALTWSKCTAGXCSQVSGSVVIDANWPXVHSTSGSTNCYTGNTWDATLCPDDVTCAANCAVDGARRQHLRVTTSGNSLRINFVTTASQKNIGSRLYLLENDTTYQKFNLLNQEFTFDVDVSNLPCGLNGALYFVDMDADGGMAKYPTNKAGAKYGTGYCDSQCPRDLKFINGQANVDGWTPSKNDVNSGIGNHGSCCAEMDIWEANSISNAVTPHPCDTPSQTMCTGQRCGGTYSTDRYGGTCDPDGCDFNPYRMGVTNFYGPGETIDTKSPFTVVTQFLTNDGTSTGTLSEIKRFYVQGGKVIGNPQSTIVGVSGNSITDSWCNAQKSAFGDTNEFSKHGGMAGMGAGLADGMVLVMSLWDDHASDMLWLDSTYPTNATSTTPGAKRGTCDISRRPNTVESTYPNAYVIYSNIKTGPLNSTFTGGTTSSSSTTTTTSKSTSTSSSSKTTTTVTTTTTSSGSSGTGARDWAQCGGNGWTGPTTCVSPYTCTKQNDWYSQCL
What are the official names of this protein?
Exoglucanase 1, 1,4-beta-cellobiohydrolase, Exocellobiohydrolase I, Exoglucanase I.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOC_NOCSJ
Sequence: MSDDSSDVKPGPKGPEQPAVEQSPENVPAPTGEVHQVGARHGMFGVRGTGDTSGYGGLNQAIVLPGDAQRPYGGWFDEVADGLAAATREAGLEIAAPRVVIHRGEITFHLRREDLLPVAQVLRDDERLRFEFCAGVSGVHYPDETGRELHAVYHLLSMTHNRRIRLEVAVPDADPHIPSIVPVYPTNDWHERETYDMFGIIFDGHPALTRILMPDDWPGHPQRKDYPLGGVPVEYKGGTVPPPDQRRSYN
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CAS2_DESVH
Sequence: MYGNDAMLVLISYDVSFEDPGGQRRLRRIAKACQDYGQRVQYSVFECVVDPAQWAKLKHRLLSEMDKEKDCLRFYYLGANWRNKVEHVGAKPAYDPEGPLIL
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Functions as a ssRNA-specific endoribonuclease.  Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).
What are the official names of this protein?
CRISPR-associated endoribonuclease Cas2.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
Protein: SCPA_BREBN
Sequence: MAYSIKLDSFEGPLDLLLHLIDKAEVDIYDIPVAEITEQYLATIDKMQELQLDVASEFVVMAATLLSIKSKMLLPKKEEHVFQQFLDMDVDEIDPREELVARLLEYKRYKMLAENLREMEIGRNQVFTRPAENLSPYVREEDHTVTNVTLYDLINALEKLVKKTKEKEPMTTVSRDEISIKDRMTEIRQAVRSGGMVRFSELFTQGATRTEIVTTFLALLELMKAKHITCVQNQLFQDIIICENGTEGAHTDGL
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein A.
What is the protein family that this protein belongs to?
Belongs to the ScpA family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: RNH2_PSE14
Sequence: MRSPIMQTGLDFTLVEDLVAGVDEVGRGPLCGAVVTAAVILDPARPILGLNDSKKLTEARREKLYVEIQEKALCWFIARAEVEEIDQLNILHATMLAMKRAVEGLSITPKLALIDGNRCPQLSVPSAPVVKGDSRVPAIAAASILAKVSRDREMAAFELIYPGYGIGGHKGYPTPVHLEALARLGPTPIHRRSFAPVRAAHEARASIMIGGSIPLPVGLLQD
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VPS27_CHAGB
Sequence: MMGWWSSGANNALDEQIDKATSSSLEDIALNLEISDIIRSKTVQPKEAMRSLKKRINNKNPNTQLSALNLTDTCVKNGGAHFLAEIASREFMESLVSLLKAVGPGTVNAEVRAKILELIQSWATAAEGRYELGYIGEVYKTLQREGYQFPPRVTVASSMIDSNAPPEWVDSDVCMRCRTAFTFTNRKHHCRNCGNCFDQQCSTKSLPLPHLGILQAVRVDDGCYAKLTDKSSKASGAPPERSFTYSSSPAKPKGSSMQPRNARVDDGFDEDLKKALAMSLEEVKSHSRGYVSSPAANGVTSNQPKPNGHAAPKAVEEEDEDLKAAIAASLADMEEQKKQHAAALKQQASGAASSSSAAPSALPKNDYELTPLEAENINLFSTLVDRLQTQPPGTILREPQIQELYDSIGALRPKLARTYGETMSKHDTLLDLHARLSTVVRYYDRMLEERLSKAYSQHSIGGYNLPPPRQAPGPYPSLQPNAPPAAGPAENFYTGEQQQEYSHPTTHQPYPQPTLAQYGAYDKRGSVSAPSSNQYPPQQVPQHTGNWGPASSAQQYGQQPSYPPNEPPQTAQLQQTPNPAHLSAPAPAPNDSIGTTPTADPSASFYFSSQAQQQQQQQQQQQQQQQQQPQQVPSSPPDPNMSPYPNLAQPLHSYQPSLPQTPASIPAQPSQPQQAHQAPPQAQQPYWQHSAAQQTQLPPVWQPPPSAAYAGYTQESFPSAPHHAPKQPVVEESLIDL
What is the function of this protein?
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 27.
What is the protein family that this protein belongs to?
Belongs to the VPS27 family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: UVRC_BACFR
Sequence: MDTNQELKTSEYLKGIVSNLPEKPGIYQYLNAEGTIIYVGKAKNLKRRVYSYFSKEHQPGKTRVLVSKIADIRYIVVNSEEDALLLENNLIKKYKPRYNVLLKDDKTYPSICVQNEYFPRVFKTRRIIRNGSSYYGPYSHSPSMHAVLDLIKHLYPLRTCNLNLSPENIRAGKFNVCLEYHIKNCAGPCIGLQSQEEYLKNIAEIKEILKGNTQEISRLLYQRMQDLAAEMKFEEAQKVKEKYALIENYRSKSEVVSSVLHNIDVFSIEEDGEKSAFINYLHITNGAINQAFTFEYKKKLNETKEELLTLGIIEMRERYKSASREIIVPFDIEIELNDVTFTIPQRGDKKKLLELSLLNVKQYKADRMKQAEKLNPEQRSMRLMKEIQQELHLDRLPMQIECFDNSNIQGTDAVAACVVFKKAKPSKSDYRKYNIKTVVGADDYASMKEVVRRRYQRAIEEESPLPDLIITDGGKGQMEVVRQVMEELQLDIPIAGLAKDRKHRTSEVLFGFPPQTIGIKQHSPLFRLLEQIQDEVHRFAITFHRDKRSKRQVASALDNIKGIGEKTKTALLKEFKSVKRIKEATIEEVSAIIGESKAKIIKEGLDNH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_MYCGI
Sequence: MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQHYIRILPEDRVVVELSPYDLTRGRIVYRYK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_HALH5
Sequence: MSSIQNKTDVILIGAGIMSATLGSLLKELKPEWEIKVFEKLANAGEESSNEWNNAGTGHAALCELNYTAEKSDGTIDISKAVKINEQFQISRQFWAYLVSQNLISNPQDFIMPIPHMSLVQGEDNVAYLKKRFKALSNIPLFEGMEFSNDPEKLKEWIPLVMEGRTSNEPIAATKIDSGTDVNFGALTRMLFEHLKEQNVEVHYKHSVKDIKRTSDGSWSVKVQEIESGTIEYHTANFVFIGGGGGSLPLLQKTGIPESKNIGGFPVSGLFMVCNNPEVVEQHHAKVYGKAKVGAPPMSVPHLDTRYIDNKKSLLFGPFAGFSPKFLKTGSNFDLIGSVKPYNVFTMLAAGAKEMSLTKYLIQQVMLSKEKRMAELREFMPNAKSEDWDIVVAGQRVQVIKDTEAGGKGTLQFGTEVVSSADGSIAALLGASPGASTAVHVMLEVLEKCFPHHMLEWQPKIKEMIPSYGVSLAENRELFQEIHQSTAEALGLSEKELVHS
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: VEMP_CVBEN
Sequence: MFMADAYFADTVWYVGQIIFIVAICLLVIIVVVAFLATFKLCIQLCGMCNTLVLSPSIYVFNRGRQFYEFYNDVKPPVLDVDDV
What is the function of this protein?
Plays a central role in virus morphogenesis and assembly.  Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport.  Also plays a role in the induction of apoptosis.
What are the official names of this protein?
Envelope small membrane protein, E protein, sM protein.
What is the protein family that this protein belongs to?
Belongs to the betacoronaviruses E protein family.
What are the subcellular locations of this protein?
Host Golgi apparatus membrane; Single-pass type III membrane protein. Note=The cytoplasmic tail functions as a Golgi complex-targeting signal.
Protein: ILVD_BACFR
Sequence: MKKQLRSSFSTQGRRMAGARALWAANGMKKEQLGKPIIAIVNSFTQFVPGHVHLHEIGQLVKKEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGELDGQHLDLIDAMIKSADESVSDEEVSKIENRACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATHANRTQLFKDAAKQIVENTYKYYRDGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLHLLAIAHEAEADFKMDDIDMLSRKSPCLCKVAPNTQKYHIQDVNRAGGIMGIMGQLAKAGLIDTSVVRIDGMTLGEAIDKYDITSPNVCEEAIKKYKSAAAGKFNLVLGSQDVYYKELDTDRAEGCIRDIEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQEAACNGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAAAGGNIGKIKDGDIIEINIPERTINVRLTDEELAARPMTPVTRERYVTKSLKAYASMVSSADKGAVRLID
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: IKKB_MOUSE
Sequence: MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLESALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
What is the function of this protein?
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses.  Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues.  These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome.  In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.  In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE.  IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs.  Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor.  Also phosphorylates other substrates including NCOA3, BCL10 and IRS1.  Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (By similarity).  Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (PubMed:30988283).  Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326420).
What are the official names of this protein?
Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, I-kappa-B kinase 2, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB, Serine/threonine protein kinase IKBKB.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Protein: BCPA_PROAE
Sequence: ALFGTKDTTTAHSDYEIILEGGSSSWGQVKGRAKVNVPAAIPLLPTDCNIRIDAKPLDAQKGVVRFTTKIESVVDSVKNTLNVEVDIANETKDRRIAVGEGSLSVGDFSHSFSFEGQVVNMYYYRSDAVRRNIPNPIYMQGRQFHDILMKVPLDNNDLVDTWEGFQQSISGGGANFGDWIREFWFIGPAFAAINEGGQRISPIVVNSSNVEGGEKGPVGVTRWKFSHAGSGVVDSISRWTELFPVEQLNKPASIEGGFRSDSQGIEVKVDGNLPGVSRDAGGGLRRILNHPLIPLVHHGMVGKFNDFTVDTQLKIVLPKGYKIRYAAPQFRSQNLEEYRWSGGAYARWVEHVCKGGTGQFEVLYAQ
What is the function of this protein?
Intermediary in the transfer of excitation energy from the chlorophyll to the reaction centers.
What are the official names of this protein?
Bacteriochlorophyll a protein, BCP, BChl a protein.
Protein: EFTS_PSYCK
Sequence: MSEVKVSAKMVKELRDRTGLGMMECKKALEESNGDVETAIDNLRKSGQAKAAKKAGNIAADGAIIIAQGDSKAFLLEVNCQTDFVAKDENFAAFAETVANLALENNVTDVAAIAELPYGNGQTVEEARVSLVQKIGENIQIRRVEVLEGANIAAYRHGLRIGVVVSYEGGSAETGKNLAMHIAAFNPVAVADEDVAADLLAREKDIIEAKARESGKPDNIVEKMIEGGLRKYLEEVTLLRQPYVMDNEKKVGDVLKAEGVKVLGFKRLEVGEGIEKKQEDFAAEVAATQALANK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SST_XANCB
Sequence: MTEFIPTGTRFHALPSPLPMKRGGVLHQARVAYETWGTLDADHGNAVLIVTGLSPNAHAAANADNPEPGWWEAMVGPGKPIDTDRWFVVCVNSLGSCKGSTGPASIDPATGAPYRLSFPELSIEDVADAAADVVRALGIAQLACLIGNSMGGMTALALLLRHPGIARSHINISGSAQALPFSIAIRSLQREAIRLDPHWNGGHYDDVQYPESGMRMARKLGVITYRSALEWDGRFGRVRLDSELTAEDPFGLEFQVESYLEGHARRFVRFFDPNCYLYLSRSMDWFDLAEYAPDTRADAAAPESGVLAGLAQIRIARALAIGANTDILFPVQQQEQIAEGLRAGGADAQFLGLDSPQGHDAFLVDFARFGPAVRAFLADC
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine.
What are the official names of this protein?
Serine O-succinyltransferase, SST.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACSC_MOOTH
Sequence: MPLTGLEIYKQLPKKNCGECGTPTCLAFAMNLASGKASLDSCPYVSDAAREALDAAAAPPIAKVVLGAGPTAVEMGDETELFRHDKRFYHETAIAIQVSDNLSSEELKAKVEAINGLNFDRVGQHYTIQAIAIRHDADDPAAFKAAVASVAAATQLNLVLMADDPDVLKEALAGVADRKPLLYAATGANYEAMTALAKENNCPLAVYGNGLEELAELVDKIVALGHKQLVLDPGARETSRAIADFTQIRRLAIKKRFRSFGYPIIALTTAANPLDEVLQAVNYVTKYASLVVLRTDAKEHLLPLLSWRQNLYTDPQVPIRVEEKLNEIGAVNENSPVYVTTNFSLTYYSVEGEIESTKIPSYLLSVDTDGLSVLTAYADGKFEAEKIAAVMKKVDLDNKVKRHRIIIPGAVAVLKGKLEDLTGWEVIVGPREASGIVAFARANLAS
What is the function of this protein?
Acts as a methyl group carrier in the anaerobic acetyl-CoA pathway (Wood-Ljungdahl pathway) of carbon monoxide and carbon dioxide fixation.  Binds the corrinoid 5-methoxybenzimidazolylcobamide which is then methylated by the AcsE subunit (PubMed:2821001).
What are the official names of this protein?
Corrinoid/iron-sulfur protein large subunit, C/Fe-SP large subunit, CFeSP large subunit.
Protein: RUVA_STAA1
Sequence: MYAYVKGKLTHLYPTHVVVETAGVGYEIQTPNSYRFQKHLDHEVLIRTSLIVREDAQLLYGFSSEEEKDMFLSLIKVTGIGPKSALAILATSTPNEVKRAIENENDTYLTKFPGIGKKTARQIVLDLKGKVKITEEDSDSLLQVDATSTVQDQFVQEAMLALEALGYSKRELAKVEKTLNKNKYDSVDEAVKAGLQLVVS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.