PharMolix/UniProtQA huggingface dataset:
Protein: CYB_THOTA
Sequence: MTIMRKSHPLFKIVNHAFIDLPTPPNISGLWNFGSLLGMCLILQILTGLFLAMHYTSDTLTAFSSVTHICRDVNYGWLIRYMHANGASLFFICLYIHIARGIYYGSYLYKETWNVGILLLFLTMATAFVGYVLPWGQMSFWGATVITNLLSAIPYVGQDLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAMVHLLFLHETGSNNPLGIVSDYDKIPFHPYYTVKDFLGVILLLLMFLTLVLFFPDKLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVIALVLSILILALLPYLHTSNQRSMTFRPLSQSLFWVLISDLFLLTWIGGQPVEPPFIIIGQLASILYFLIILILMPIAGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: BIR1G_MOUSE
Sequence: MAEHGESSEDRISEIDYEFLAELSARFGMNLVQLAKSQEEEDHKERMKMKKGFNSQMRSEAKRLKTFESYDTFRSWTPQEMAAAGFYHTGVKLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKSPEKMLRGGKARYHEEEARLESFEDWPFYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFLQSKKSSEEIAQYIQGYEGFVHVTGEHFVKSWVRRELPMVSAYCNDSVFANEELRMDMFKDWPQESPVGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFPECVFLQTLKSSAEVIPTLQSQYALPEATETTRESNHGDAAAVHSTVVDLGRSEAQWFQEARSLSEQLRDTYTKTSFCHMNLPEVCSSLGTDHLLSCDVSIISKHISQPVQGALTIPEVFSNLSSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLDNIICTQLLGAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLFRTCLLIAVHTNRVRDIRPYLGTSLEIQEFPFYNTVFVLRKFFSHDIICVEKLIIYFSENKDLQGVYKTPLFVAAVCNDWNQNASAQDDFQDVTLFHSYMQYLSLKYKATAESLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDVKLTTFLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSKAAPTVVSHLLQLVDEKESLENMSENEDYMKLHPQTFLWFQFVRGLWLVSPESFSSFVSEHLLRLALIFAYESNTVAECSPFILQFLRGRTLALRVLNLEYFWDHPESLLLLRSLKVSINGNKMSSYVDYSFKTYFENLQPPAINEEYTSAFEHVSEWRRNFAQDEEIIKNYENIWPRALPDISEGYWNLSPKPCKIPKLEVQVNNMGPADQALLQVLMEVFSASQSIEFHLFNSSGFLESIRPALELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPDQLFHNLHKFLGLKELCVRLDGKPDVLSVLPEEFLNLHHMEKLSIRTSTESDLSKLVKFIQNFPNLHVFHLKCDFLSNCESLMTALASCKKLREIEFSGQCFEAMTFVNILPNFVSLKILSLKGQQFADKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLAFHDILDDESVIEIGAATSGSFQKLENLDISMNHKITEEGYRNFFQALDNLPNLQMLNICRNIPGRIQVQATTVKALCHCVSRLPSLTRLGMLSWLLDEEDMKVINDVKERHPQSKRLTIFWKWIVPFSPVVLE
What is the function of this protein?
Prevents motor-neuron apoptosis induced by a variety of signals.
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 1g, Neuronal apoptosis inhibitory protein 7.
Protein: LGAT1_MOUSE
Sequence: MAVTVEEAPWLGWIVAKALMRFAFMVANNLVAIPSYICYVIILQPLRVLDSKRFWYIEGLMYKWLLGMVASWGWYAGYTVMEWGEDIKAIAKDEAVMLVNHQATGDVCTLMMCLQDKGPVVAQMMWLMDHIFKYTNFGIVSLIHGDFFIRQGRAYRDQQLLVLKKHLEHNYRSRDRKWIVLFPEGGFLRKRRETSQAFAKKNNLPFLTHVTLPRFGATNIILKALVARQENGSPAGGDARGLECKSRGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIGDVPLETEDLTSWLYQRFIEKEDLLSHFYKTGAFPPPQGQKEAVCREMTLSNMWIFLIQSFAFLSGYLWYHIIQYFYHCLF
What is the function of this protein?
Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (PubMed:35131264).  Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524).  Acts in concert with an unknown phospholipase A1 to convert palmitate PE species into stearate ones.  Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (PubMed:35131264).  Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (By similarity).  Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (PubMed:20018982, PubMed:35131264).  Has no activity toward lysophosphatidic acids (LPA) and lysophosphatidylcholines (LPC) (PubMed:35131264).
What are the official names of this protein?
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1, 2-acylglycerophosphocholine O-acyltransferase, Acyl-CoA:monoacylglycerol acyltransferase LPGAT1, Lysophospholipid acyltransferase 7, LPLAT7, Stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RTN4_HUMAN
Sequence: MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE
What is the function of this protein?
Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity).  With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550).
What are the official names of this protein?
Reticulon-4, Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5.
Protein: AC4CH_SHESA
Sequence: MLTKITFFERFEQDILSGAKTITLRNEAESHVFAGQILPVSTFEADRWFCDIKVIEVVPVLFSALTEQHAAQENMTLPELRRVIQEIYPGLEQLFQIHFCVVNTRAHPIN
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: BOP1_DROPE
Sequence: MTKKLTIKRKVKEPEPQNEAPDSHESSDNEEEEEDLLQAVKDPGEDSTDDEGIDQEYQTDSSEDLEFESDEEGNYLGRKGAEGSSGDDDEESAEDEEEEDDADAKKSSKNNDEEAATTSKSIKKSQEKPTSSNKVVPVVPARDPSKVEYADSDTSDEEDIRNTVGNIPMHWYDEYKHIGYDWDAKKIVKPPKGDQIDDFLRKIEDPNFWRTVKDPLTGQEVLLTDADIALIKRINSGRIPNEEHDEYAPWIEWFTSEVEKMPIKNVPDHKRSFLPSGSEKKTVSRMVHALKMGWMKTTEEVQREKQEKRGPKFYMLWETDTSREQMRRIHDPVSAPKRDLPGHAESYNPPPEYLFDEKEAKEWHKLKDEPHRRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDLQPFPTVESLVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIETEDVVRCVAWCPNAKLSIIAVATGSRLLLVNPKVGDKLLVKKTDDLLAEAPVLDVIENERIKTAVQWANAEPADQEKGVRVIITHFKPIRQVTWHGRGDYLATVMPEGANRSALIHQLSKRRSQIPFSKSKGLIQCVLFHPVKPCFFVATQHNIRIYDLVKQELIKKLLTNSKWISGMSIHPKGDNLLVSTYDKKMLWFDLDLSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIVSHGMVYNDLLQNPLIVPLKKLQTHEKREEFGVLDVNWHPVQPWVFSTGADCTIRLFT
What is the function of this protein?
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein BOP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: OFUT2_CAEEL
Sequence: MHFFPIQLLVLFFAEKIAFAENSDQTVSRVDSNRYSVAAEKKFLLYDVNFGEGFNLRRDVYMRVANTVRSLRDSGENYILVLPPWGRLHHWKRMEVALSWRLFFDLESLNRFIPVIEFEDFLDENRPIDQVIYLQHYAEGWGTEYVRKFEKRSCLPPAESHYKQVEEFKWKGWFYSYEDVYSRNFQCVSIQGDSGTLKDLLKHSNFSESTSIMVDRAETILHEHYGEVDYWKARRSMRYSNDLVDVADAFRKKYLDSDDKRDKTKLVDDWTKEKPRRTAIGGPYLGIHWRRRDFLYARRAQLPTIPGTAKILQDLCKKLDLQKIYLATDAPDQEVDELKALLNGELEVYRFTDTQKLNDGQIAIIDQYLCAHAAYFIGSYESTFTFRIQEDREIIGFPISTTFNRLCPDTEPTCEQPAKWKIVY
What is the function of this protein?
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:15233996, PubMed:26854667).  O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombospondin (TSP) and spondin families (By similarity).
What are the official names of this protein?
GDP-fucose protein O-fucosyltransferase 2, Patterning defective protein 2, Peptide-O-fucosyltransferase 2, O-FucT-2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 68 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Golgi apparatus. Note=Mainly located in the endoplasmic reticulum.
Protein: ADA_MOUSE
Sequence: MAQTPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMDKPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKSTLDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:9272950, PubMed:8634299, PubMed:10720488, PubMed:8672487, PubMed:8942668).  Plays an important role in purine metabolism and in adenosine homeostasis (PubMed:9272950, PubMed:10720488).  Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (PubMed:11435465).  Acts as a positive regulator of T-cell coactivation, by binding DPP4.  Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity).  Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity).  Enhances CD4+ T-cell differentiation and proliferation (By similarity).  Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity).  Stimulates plasminogen activation (By similarity).  Plays a role in male fertility (By similarity).  Plays a protective role in early postimplantation embryonic development (PubMed:9272950).
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Lysosome. Note=Colocalized with DPP4 at the cell surface.
Protein: PAHO_RANTE
Sequence: APSEPHHPGDQATQDQLAQYYSDLYQYITFVTRPRF
What is the function of this protein?
Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions.
What are the official names of this protein?
Pancreatic polypeptide, PP.
What is the protein family that this protein belongs to?
Belongs to the NPY family.
What are the subcellular locations of this protein?
Secreted.
Protein: PRPE_GEOSW
Sequence: MKIDIIGDIHGCYSEFVKLTKKLGYEWDSGIPLHPDGRKLGFVGDLTDRGPQSLQTVEVVYSLVERESAYYVPGNHCNKLYRFFLGRNVQITHGLETTVEEYRALPPSEQAMIRKKFMRLYEAAPLYAQLDNGRLIIAHAGLRRDYIGRNDKKVQTFVLYGDITGETNPDGTPVRRDWAKRYKGSAWIVYGHTPVKQPRIINRTINIDTGCVFGGALTAFRYPEIETISVPSSLPYVPEKFRTFD
What is the function of this protein?
Asymmetrically hydrolyzes Ap4p to yield AMP and ATP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase PrpE [asymmetrical], Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the PrpE family.
Protein: DNAK_FRATW
Sequence: MGKIIGIDLGTTNSCLAIMDGKTAKVIENAEGHRTTPSVVAYTDSGEILVGQAAKRQAVTNPDNTFFAIKRLIGRKYDDKAVQEDIKKKVPYAVIKADNGDAWVATKEGKKMAPPQVSAEVLRKMKKTAEDYLGEPVTEAVITVPAYFNDSQRQATKDAGKIAGLEVKRIINEPTAAALAYGVDSKKGEQTVAVYDLGGGTFDISIIEIADVDGDNQIEVLSTNGDTFLGGEDFDLALMNYLIDEFKKEQGIDLHNDKLALQRVREAAEKAKVELSSAQQTDVNLPYITADATGPKHLNIKVTRAKFESLVSDLVMRSLEPCKKALEDAGLSKSDITEVLLVGGQTRMPLVQEKVKEFFGKEPRKDVNPDEAVAVGAAIQGGVLSGDVKDILLLDVTPLSLGIETMGGVMTKLIERNTTIPTKKSQVFSTAEDNQPAVTIHVLQGEREMASANKSLGRFDLADIPPAPRGMPQIEVTFDIDANGILNVSAKDKATGKEQNIVIKSSSGLSEEDIEKMVQDAEANAEADKKFHDLVTARNTADNLIHSSRKAIQELGDKVTAAEKEKIEEACKELEAATKGDDKQAIEAKTKALEEAFAPIAQKAYAEQAQAAVAQGGAKAEEPKKEEDVVDADFEDVEDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: PURT_LEPIC
Sequence: MKKKILLLGSGELGKEFVIAAQRLGQYVIAVDSYDDAPAMQVAHEKEIINMLDGNLLDQIIAKHKPDLIVPEIEAIKTERFYEYEKQGYQVVPSAKAANFTMNRKSIRDLAAKDLKLLTAKYAYASSIDELIKATEILGFPCVVKPLMSSSGKGQSVIQSREEISKAWEASQTKGRAGAAEIIVEEFIPFESEITLLTVTQKNGKTLFCPPIGHRQERGDYQESWQPAAISEVQLKEAQRMADAVTKELTGFGIWGVEFFLTEDKVYFSELSPRPHDTGMVTLAGTQNFNEFELHLRAILGIPILEITLERKGASAVILASTENKTPEISGLDIASGMSESDFRIFGKPITRPYRRMGVTLSYSTKGEEISSLRKRAVLLASKIKVD
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: CITD_CLOPS
Sequence: MEIKKPALAGTLESSDCIVSVEPSRDNTIEINLTSTVKKQFGNEIIRVAKEALKNLGVNSVVMEINDKGALNCVIEARIEAAICRASEINEFDWGNYKCQD
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O1165_MOUSE
Sequence: MMLDLGNESSVTMFILSGFSEYPHLHAPLFLLFFMIYTVTLIGNLGIIVVRKVNPKLHTPMYFFLSHLSFLDICYSSVFTPKLLEILIVEDRTISFKGCMTQFFLICAFVITEMFMLAVMAYDRFVAVCNPLLYTVSMSPKLCAFLVAGTYMWGVLCSLTITYSLLQLSYCGPNIINHFGCEYSAILSLSCSDPTFSQVVCLTISIFNETCSLLIILASYVFIVVTIIKMPSKGGLQKAFSTCSSHLTAISIFHGIILLLYCVPNSKNSWLVVKVATVLFTVMIPMLNPLIYSLRNKDVKGTVSRLMHLKLQAHST
What is the function of this protein?
Olfactory receptor.
What are the official names of this protein?
Olfactory receptor 1165.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CCMO_SYNY3
Sequence: MPTSPTMTSVPIARSPRPSYQQINQHQPSDSALGLVSTRSFPAIVGTADMMLKSSQVTLVGYEKIGSGYCTAVVRGKVADVRLAVEEGARTAEQFGQLVSKLVIPRPMPNLQAVFPIGSHLVELAQQQRGYSRLSNRSIGLLETRGFPAMVGAADAMLKSADVQLASYEIIGDGLCTAIVRGTVANVAMAIEVGMQEAERIGELHAVMIIPRLLEDLEHTLPVATYWLDENEPLPMLLPNQVREKQRQLVALPELEKAVVPQRQAKPLPLQEKTEAPLVLEKEAEKPIVEVLGPEID
What is the function of this protein?
Required for formation of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered.  Required for recruitment of major shell protein CcmK2 to the pre-carboxysome.  Suggested to be a carboxysome shell protein.
What are the official names of this protein?
Carboxysome assembly protein CcmO, Carbon dioxide concentrating mechanism protein CcmO.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family.
What are the subcellular locations of this protein?
Carboxysome. Note=This cyanobacterium makes beta-type carboxysomes.
Protein: GLC_ARATH
Sequence: MGSSYQESPPLLLEDLKVTIKESTLIFPSEETSERKSMFLSNVDQILNFDVQTVHFFRPNKEFPPEMVSEKLRKALVKLMDAYEFLAGRLRVDPSSGRLDVDCNGAGAGFVTAASDYTLEELGDLVYPNPAFAQLVTSQLQSLPKDDQPLFVFQITSFKCGGFAMGISTNHTTFDGLSFKTFLENLASLLHEKPLSTPPCNDRTLLKARDPPSVAFPHHELVKFQDCETTTVFEATSEHLDFKIFKLSSEQIKKLKERASETSNGNVRVTGFNVVTALVWRCKALSVAAEEGEETNLERESTILYAVDIRGRLNPELPPSYTGNAVLTAYAKEKCKALLEEPFGRIVEMVGEGSKRITDEYARSAIDWGELYKGFPHGEVLVSSWWKLGFAEVEYPWGKPKYSCPVVYHRKDIVLLFPDIDGDSKGVYVLAALPSKEMSKFQHWFEDTLC
What is the function of this protein?
Required for double fertilization of the egg cell and the central cell by two sperm cells, resulting in the formation of the embryo and the endosperm (PubMed:22872756, PubMed:17965055).  Involved in the regulation of embryonic expression of PHE1 (PubMed:17965055).  Essential in maternal tissues to ensure the paternal embryonic expression of several genes, including RPS5a and FAC1, both of which being essential for early embryo and endosperm development in fertilized seeds (PubMed:17965055).
What are the official names of this protein?
Acyltransferase GLAUCE.
What is the protein family that this protein belongs to?
Belongs to the plant acyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GBA1_PIG
Sequence: MELSSPSREECPRPQGRVGIMAASLMGLLLLQAASWASGARPCSPKSFGYSSVVCVCNATYCDSLDPLTLPDPGTFSRFESTRSGRRMELSLGTFQANRTSKGLLLTLQPDQKFQKVKGFGGAMTDAAALNILALSPQARNLLLKSYFSEEGIEYNIIRVPMASCDFSIRIYTYADTPDDFQLLNFSLPEEDVKLKIPLIHQALKMAQRPVSLFASPWTSPTWLKTNGAVNGKGTLKGHPGDRYHQTWAKYFVKFLDAYAEHNLHFWAVTAENEPSAGLFTGYPFQCLGFTPEHQRDFIARDPGPTLANSTHRNVRLLMLDDQRLLLPHWAQVVLADPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGVQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDISKDTFYKQPMFYHLGHFSKFIPEGSQRVGLAASEKNNLDTVALLRPDGSAVVVVLNRSSKDVPLTIKDPALGFLETISPSYSIHTYLWHRK
What is the function of this protein?
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose.  Plays a central role in the degradation of complex lipids and the turnover of cellular membranes.  Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation.  Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol.  GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine).  Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide.  Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol.  Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers.  Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside.
What are the official names of this protein?
Lysosomal acid glucosylceramidase, Acid beta-glucosidase, Beta-glucocerebrosidase, Cholesterol glucosyltransferase, SGTase, Cholesteryl-beta-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, Lysosomal cholesterol glycosyltransferase, Lysosomal galactosylceramidase, Lysosomal glycosylceramidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
Protein: YIL2_STAAU
Sequence: MYNFDYSKLPIKNIQKIFPIAGGYVNLSFSVDASNKKYFLKLQPNTKSNFFDYELSSLKELTDKNIPVPQIINKGELDNNSFLLLEFIENGHAYPESYRKLGKIVANMHKNINSLNLFGFSHNFNGGTIEF
What are the official names of this protein?
Uncharacterized protein in ileS 3'region, ORF C.
Protein: END4_SULNB
Sequence: MKFVGAHVSASGGVDNAPLNAMAIGAKAFAVFAKNQRQWVAKPLEEKTIEAFKKNLETAGILPKHVLPHDSYLINLGHPEEEKLEKSRAAFIDELERCNQLGLDKLNFHPGSHLVKIPKKDPEYHEKLMEAELHCLDVIAESMNLAIEATKGSDVKLVIENTAGQGTNLGYKFEHLAHLIEKVEDKSRVGVCLDTCHTFTAGYDLRTREAYDETMDAFERIVGFEYLMGMHINDSKPKLGSRVDRHASLGQGEIGWDAFCFIMNDPRMDDIPLILETIDESLWPEEIKALYALVKK
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: CH60_LEPBP
Sequence: MAKTIEFDETARRKLLSGVNKLANAVKVTLGPKGRNVVIDKKFGSPTITKDGVTVAKEIELEDAIENMGAQMVKEVSTKTNDIAGDGTTTATILAQAIINEGLKNVTAGANPMALKHGIDKAVVVAVEEIKKHAIKINSKAEYANVATISANNDPEIGNLIAQAFDKVGKEGVITVDEAKSIETTLDIVEGMQFDRGYVSPYMVTDPEAMIATFNDPFILIYDKKIASMKDLLPVLEKIAQAGRPLVIIAEEVEGEALATIVVNTLRKTIQCVAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGMKLENADVKMLGRAKKVVVDKENTTIIEGAGASKDIQGRVNQIKKQIEDTTSDYDREKLQERLAKLAGGVAVIHVGAATEVEMKEKKARVEDALSATRAAVEEGIVPGGGLTLLRAQDAVKALKLVGDEQTGANIILRALEEPIRMITSNAGLEGSVIVEQARARKGNEGFNALTMVWEDLIKAGVVDPAKVVRSALQNAASIGAMILTTEVTITDKPEPKDASGAGMGGMGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NPT3_HUMAN
Sequence: MDGKPATRKGPDFCSLRYGLALIMHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPVADAFNNSSISIKEFDTKASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILSSLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGIISSTATGFLISQVGPVY
What is the function of this protein?
May be involved in actively transporting phosphate into cells via Na(+) cotransport.
What are the official names of this protein?
Sodium-dependent phosphate transport protein 3, Na(+)/PI cotransporter 3, Sodium/phosphate cotransporter 3, Solute carrier family 17 member 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.