PharMolix/UniProtQA huggingface dataset:
Protein: IL13_MACTH
Sequence: MALLLTMVIALTCLGGFASPSPVPPSTALKELIEELVNITQNQKAPLCNGSMVWSINLTAGVYCAALESLINVSGCSAIEKTQRMLNGFCPHKVSAGQFSSLRVRDTKIEVAQFVKDLLLHLKKLFREGQFN
What is the function of this protein?
Cytokine that plays important roles in allergic inflammation and immune response to parasite infection.  Synergizes with IL2 in regulating interferon-gamma synthesis.  Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity).  Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity).  Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity).  Functions also on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils.  Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6.  Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity).
What are the official names of this protein?
Interleukin-13, IL-13.
What is the protein family that this protein belongs to?
Belongs to the IL-4/IL-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SDHF2_BOVIN
Sequence: MAVVAVFPALARMLAVSRRRLVSPSLSMTSCRRCYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMTLLRDFAKNKNKEQRLRAPDLEYLFEKPH
What is the function of this protein?
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol.  Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
What are the official names of this protein?
Succinate dehydrogenase assembly factor 2, mitochondrial, SDH assembly factor 2, SDHAF2.
What is the protein family that this protein belongs to?
Belongs to the SDHAF2 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: KBP_HUMAN
Sequence: MANVPWAEVCEKFQAALALSRVELHKNPEKEPYKSKYSARALLEEVKALLGPAPEDEDERPEAEDGPGAGDHALGLPAEVVEPEGPVAQRAVRLAVIEFHLGVNHIDTEELSAGEEHLVKCLRLLRRYRLSHDCISLCIQAQNNLGILWSEREEIETAQAYLESSEALYNQYMKEVGSPPLDPTERFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHLEMFEKAAHYCHSTLKRQLEHNAYHPIEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKISATEDTPEAEGEVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESIRKKAVQFGTGELCDAISAVEEKVSYLRPLDFEEARELFLLGQHYVFEAKEFFQIDGYVTDHIEVVQDHSALFKVLAFFETDMERRCKMHKRRIAMLEPLTVDLNPQYYLLVNRQIQFEIAHAYYDMMDLKVAIADRLRDPDSHIVKKINNLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCEKHPEAAQEIEVELELSKEMVSLLPTKMERFRTKMALT
What is the function of this protein?
Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
What are the official names of this protein?
KIF-binding protein, KIF1-binding protein, Kinesin family binding protein.
What is the protein family that this protein belongs to?
Belongs to the KIF-binding protein family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: INF2_XENLA
Sequence: MSLTEGAHTKWGVLKQKLGPQDPDQIEGNLENADPELCIRLLQIPSVVNYSGLKKRLESSDDEWMCQFLELSGLDLLLEALDRLSGRGVARIADALLQLTCINCVRTLMNSHKGIEYIVNNEGYVRKLSQALDTSNVMVKKQVFELLAALCIYSPEGHALCLDALEHYKVVKNQQYRFSVITNELSSSDNVPYMVTLLSVINAIIFGTEELRNRVQLRNEFIGLQLLDLLTKLRDLEDEDLLIQALVFEEAKSEDEEELLKIYGGINMNNHQEVFSTLFNKVSCSPLSVQLLSILQGLLQLDQSHPTSPLLWEALEVLVNRAVLLADDCQNNNVEEVMDRLVTSKKLSSKEKRKTDKCTNKVNKSIQTDKPKEESCEGKTVKKDPVSSGIPADSLQLLDALLAPPTKEDSPACITPLHTHLSGELTCSSVLPSPPSPLVPNADERISSSSSPLPPPPPPLPGTELSPPPPGMVALSLPPPPPPLPGMGGMLPPPPPPLPGMGGMLPTPPPPPLPGMGGMLPPPPPPLPGMGGMLPPPPPPLPGMGGMLPPPPPPLPGMGGMLPPPPPLPGMGGMLPPPPPPLPGMGGMPPPPPPMPGMGTFTDEVVVARVDYSLGYLPKAFLKVNKPTLKMKKLNWQKIPPNVIKDSHSMWASASSIEDTVEPNYSSIEQLFCLPQAAVKESAVPVKKPPKEITFLDSKKNLNLNIFLKQFKCPNKEVIELIEKGDRSRFDIEILKQFLKLLPEKHEVENLKSYQEDKAKLSNADQFYLLLLGVPCYQLRIECMLICEEINLMIDMIRPRAKVVSSACDDIISSHRLPLFCQLILKVGNFLNYGSHTGNANGFKISTLLKLTETRANQTRITLLHHILEEIEHNHTDLLQLPTDLENVSTVAGINIENMYTETSGNLKKLRDLQNKISTAATDVKEQYEKSIQDCMDTLKELEEQLTDISQKKVKLADYLCEDPTKLSLEETFSTMKAFRELFLKAKKDNKDRKEQAVKAEKRKQQIADEETKRQKGENGKIIRKGAAKLEEGCIIDDLLADIKKGFQLRKTAKTKTKADACPKTLSSETNRTDIQHVGKRPEVPPVHPQRKIIILKRQ
What are the official names of this protein?
Inverted formin-2.
What is the protein family that this protein belongs to?
Belongs to the formin homology family.
Protein: RECF_ENTFA
Sequence: MRLNELTLQHYRNYETVSLDFPKTLNLFLGENAQGKTNLLESIYVLAMTRSHRTSNEKELIGWEQAAAKISGVVEKKTGTVPLEILISNKGRKTKVNHIEQKRLSAYIGQLNVILFAPEDLSLVKGSPQVRRKFIDMELGQVSPIYLYDLVQYQSVLKQRNQYLKQLAEKKQTDTVYLDILTEQLAEFGGKVLYARLGFLKKLEHWANLLHQKISHGRETLTIDYASSIPIDNTDLSLEALQNQLLQQLMNNRKRELFKANTFLGPHRDDLLFIVNGQNVQTYGSQGQQRTTALSIKLAEIDLMHSETGEYPVLLLDDVMSELDNERQIHLLETIEGKVQTFLTTTSLDHIKDKLTVEPDIFYVQQGKIERNSAT
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_STRPJ
Sequence: MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFSGYSIGGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCNNYTRAYLRHLLKADETFGIRLTSYHNLYFLLNLMKQVRQAIMDDNLLEFREYFVEKYGYNKSGRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: EX7L_ECO57
Sequence: MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEGLFDLQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQCNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSTRQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLERLQKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAETLRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGKVLKKVKQVKAGEMLTTRLEDGWVESEVKNIQPVKKSRKKVH
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCW3_SCHPO
Sequence: MSDYKSLKVAELREKLAEKGLSTAGNKAELVSRLTAATESNDENTSNNNATDLGDLAPPEDDIDWGDMENDTISTDVNKPAEPESKETSAPAAAVEIEKENESIISKETSQAPETSTGAEEHQETTEESKQSVSNEVSSPDVAKEQEKLIQRAKRFGIPVDDEQIKKAARAARFGIQQPLASSNNKNHNQSKNPQNRSNSRSKQRNKNAPPKSAPSKRKSNILDDPIEAEKARKRAERFGVAAKN
What are the official names of this protein?
Uncharacterized protein C31H12.03c.
Protein: Y2488_NOSS1
Sequence: MIVTTTDVIQGAVIDSYLGIVTAEIVYGSNFLRDFLAGIRDVIGGRTGSYERLFEQGQRKAIEELELRAQRLGANAVIGIEIDTGTINVDQSGVLLLITATGTAVRVR
What are the official names of this protein?
UPF0145 protein alr2488.
What is the protein family that this protein belongs to?
Belongs to the UPF0145 family.
Protein: HEM6_ECO81
Sequence: MKPDAHQVKQFLLNLQDTICQQLSAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP61_MRDV
Sequence: MDRPAREHLKFSKANTKNEIREMRIYKDDTADGLCFSEINVGCTSTTPKMSLSDYFSSVSCSFDGEMRIPDIPLKMYGDLHFHEQFTNDVDLDLLCWQLLSSNQDSRALCVNILRMVTSLSLGNAFISEGRYHYAIDTTEQTSAEDSDALRFLARIAKIVIKNDVDKSDVVAAQQTLIYYYFGNSYQGIHLNWDSKSSQQSIHGYSTSEVCLDHYIRMKVDLFHGLRSKNLVYGGNYQLVYQALFYYYVITNGRFSSGFNVRKDSIKSYFVPNDDPSMCNVSPRKPSLSLMFIRAVLITILIKDYSPVKEIPKYLRQLEVENPLTNSCLITDNGLRSEVPMNAAAPSAPTPTELPVFSPPSS
What are the official names of this protein?
Probable non-structural 41.0 kDa protein.
Protein: TSAD_BRUME
Sequence: MRVLGIETSCDETAAAIVERDDMGEGRILSNVVLSQIAEHEPYGGVVPEIAARAHVEALDRLVDRALNDAGLKLYEVDAVAATAGPGLIGGLIVGLMTAKALAMAAQKPFYAVNHLEGHALTARLTDGLPFPYLLLLVSGGHTQMVLVRGIGDYERLGTTIDDALGEAFDKTAKLLGLPYPGGPAVERMALQGDQKRFALPRPLKGEARLDFSFSGLKTAVRQTATELVPLTDQDVTDICASFQAAVADTLSDRVGRSLERFKTEFPDCATPSLVVAGGVAANKTLRAALENLCTRHGFAFIAPPLNLCTDNAAMIAWAGAERAATQAPDSLDIAPRSRWPLDEKSAPVFGTGRRGAKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_VIBVY
Sequence: MYAVFQSGGKQHRVSEGQTLRLEKLDVETGATVEFDKVLLVANGEDIKVGAPLVEGGKVVAEVVQHGRGDKVKIVKFRRRKHSRKQQGHRQWFTEVKITGINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: HTF4_MESAU
Sequence: EFHDRLSYPPHSVSPTDISTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGARGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLTGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPTSHSDIHSLLGPSHNAPIGNLNSNYGGSSLVTNSRSASMVGTHREDSVNLNGNHSVLSSTVAASNTDLNHKTPENYRGGLQNQSGNVVPTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSAASAEPPTTLPGTHPGLSETTNPMGHL
What is the function of this protein?
Transcriptional regulator.  Involved in the initiation of neuronal differentiation.  Activates transcription by binding to the E box (5'-CANNTG-3').  Participates in the control of inducible RP4 gene expression in salivary cells (By similarity).  Binds to the RIPE3 element of the insulin II promoter (By similarity).  May be involved in the functional network that regulates the development of the GnRH axis.
What are the official names of this protein?
Transcription factor 12, TCF-12, Beta-cell E-box transcriptional activator 1, BETA1, DNA-binding protein HTF4, E-box-binding protein, Transcription factor HTF-4.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1607_AGRFC
Sequence: MAKRPALPSADLSPTSGFEAGEGDLFNGADERGFFAEPRSAPKKAARAVTATEQEADAAHYHGHRDRLRTRYRDGGDAALADYELLELLLFRLIPRRDTKPIAKALIARFGTLGSVLGAPLPLLQEVKGVGEAVALDLKLVASVSQRMLKSEIRNKQVLGSWSSVIDYCHAAMAHETREQFRILFLDKRNVLIADEVQGQGTVDHTPVYPREIVRRALELSSTALILIHNHPSGDPTPSRADIEMTKTIIDTAKPLGITVHDHIIIGKDGHASFKGLRLI
What are the official names of this protein?
UPF0758 protein Atu1607.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: HEMA_I35A3
Sequence: MKARLLVLLCALAAADADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCRLKGIPPLQLGKCNIAGWLLGNPECDSLLPARSWSYIVETPNSENGACYPGDFINYEELREQLSSVSSFERFEIFPKESSWPKHNTTKGVTAACSHAGKSSFYRNLLWLTKKEDSYPKLKNSYVNKKGKEVLVLWGVHHPSSSKEQQTLYQNENAYVSVVSSNYNRRFTPEIAERPKVRDQTGRMNYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNASMHECNTKCQTPQGAINSSLPFQNIHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSRGLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAINGITNKVNSVIEKMNTQFTAVGKEFNNLEKRMENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVKNLYEKVKSQLKNNAKEIGNGCFEFYHKCDNECMESVRNGTYDYPKYSEESKLNREKIDGVKLESMGVYQILAIYSTVASSLVLLVSLGAISFWMCSNGSLQCRICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: ADH_DROLE
Sequence: MDLTNKNVIFVAALGGIGLDTSRELVKRNLKNFVILDRVENPTALAELKAINPKVNITFHTYDVTVPVAESKKLLKKIFDQLKTVDILINGAGILDDHQIERTIAINFTGLVNTTTAILDFWDKRKGGPGGIIANICSVTGFNAIHQVPVYSASKAAVVSFTNSLAKLAPITGVTAYSINPGITRTPLVHTFNSWLDVEPRVAELLLSHPTQTSEQCGQNFVKAIEANKNGAIWKLDLGTLEAIEWTKHWDSHI
What are the official names of this protein?
Alcohol dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: EXT2_HUMAN
Sequence: MCASVKYNIRGPALIPRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRSIRDVPVVRLPADSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISDSDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDLEALQVKHGESVLVLDKCTNLSEGVLSVRKRCHKHQVFDYPQVLQEATFCVVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWGSVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL
What is the function of this protein?
Glycosyltransferase required for the biosynthesis of heparan-sulfate.  The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone.  Appears to be a tumor suppressor.  Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
What are the official names of this protein?
Exostosin-2, Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Multiple exostoses protein 2, Putative tumor suppressor protein EXT2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 47 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type II membrane protein. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.
Protein: FCRL2_HUMAN
Sequence: MLLWSLLVIFDAVTEQADSLTLVAPSSVFEGDSIVLKCQGEQNWKIQKMAYHKDNKELSVFKKFSDFLIQSAVLSDSGNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPIEGGPVSLKCETRLSPQRLDVQLQFCFFRENQVLGSGWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQCSEAVPVSISGPDGYRRDLMTAGVLWGLFGVLGFTGVALLLYALFHKISGESSATNEPRGASRPNPQEFTYSSPTPDMEELQPVYVNVGSVDVDVVYSQVWSMQQPESSANIRTLLENKDSQVIYSSVKKS
What is the function of this protein?
May have an regulatory role in normal and neoplastic B cell development.
What are the official names of this protein?
Fc receptor-like protein 2, FcR-like protein 2, FcRL2, Fc receptor homolog 2, FcRH2, IFGP family protein 4, Immunoglobulin receptor translocation-associated protein 4, SH2 domain-containing phosphatase anchor protein 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: NUON_BEII9
Sequence: MTPLPVVLAHALPELILAGGVLLLILIGAIRGKDSDGPMTELAVGLLGIAILTLVLGTKTQAVLFDGSFIDDAFGRFMKVLVLIGSLVSLIMGQTYLAREKIDKFEFPILILLSTLGMLMLISATGLIALYLGLELMSLALYVIAAFHRDDVKASEAGLKYFVLGALSSGMLLYGASLIYGFAGTVNFTGIATALHGETSLGVVFGLVFLTAGLAFKMSTVPFHMWTPDVYEGAPTPVTAFFASAPKLAAIAITMRIMITAFAGIKPQWQQIIVFISILSMALGSFAAIGQTNIKRLMAYSSIGHMGFALVGLAAGTETGIQGVLAYMAIYLVMTLGTFAAILSMRVNGVNVEQISDLAGLARTRGSMAFFLAIMMFSLAGIPPLAGFFAKWYVFNAAIQAHLYPLAVIGVLCSTVGAYYYLRIVKVMYFDDPAPAFDRPTPTLAAVLIVTGLAVLLLCVYPGSFVEATTVAARSLF
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit N, NADH dehydrogenase I subunit N, NDH-1 subunit N.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ACOT4_MOUSE
Sequence: MAATLSVEPTGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGALFRAHARYRADSHGELDLARVPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPFLVELEVLDGHEPDGGRRLARTVHERHFMAPGVRRVPVREGRVRATLFLPPGQGPFPGIIDVYGVGGGLLEYRAGLVAGHGFATLALAFYDFEDLPKELNVIEVDYFEEAVRYMLRHPKVKGPDIGLLGLSLGADVCLIMASFLNNVSATVSINGSAFSGNRHIKYKQTMIPPLGHDLRRMKVAFSGILDIVDIRNDAVGGCENPSMIPIEKAKGPILFVAGQDDHCWRSELYTQIASDRLQAHGKERPQVLSYPGTGHYIEPPYFPMCPASLHKIVNEAVIWGGEVKAHSKAQIDAWKQILFFFGKHLGSTHSRASCRL
What is the function of this protein?
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16141203, PubMed:16940157).  In contrast to its human ortholog, functions essentially as a succinyl-CoA thioesterase with no activity with medium to long chain saturated acyl-CoAs and with a low activity toward glutaryl-CoA (PubMed:16141203, PubMed:16940157).
What are the official names of this protein?
Peroxisomal succinyl-coenzyme A thioesterase, Acyl-coenzyme A thioesterase 4, Acyl-CoA thioesterase 4, PTE-2b, Peroxisomal acyl coenzyme A thioester hydrolase Ib, Peroxisomal long-chain acyl-CoA thioesterase Ib, PTE-Ib.
What is the protein family that this protein belongs to?
Belongs to the C/M/P thioester hydrolase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: G1P_BPF1
Sequence: MAVYFVTGKLGSGKTLVSVGKIQDKIVAGCKIATNLDLRLQNLPQVGRFAKTPRVLRIPDKPSISDLLAIGRGNDSYDENKNGLLVLDECGTWFNTRSWNDKERQPIIDWFLHARKLGWDIIFLVQDLSIVDKQARSALAENVVYCRRLDRITLPFVGTLYSLITGSKMPLPKLHVGVVKYGDSQLSPTVERWLYTGKNLYNAYDTKQAFSSNYDSGVYSYLTPYLSHGRYFKPLNLGQKMKLTKIYLKKFSRVLCLAIGFASAFTYSYITQPKPEVKKVVSQTYDFDKFTIDSSQRLNLSYRYVFKDSKGKLINSDDLQKQGYSLTYIDLCTVSIKKGNSNEIVKCN
What is the function of this protein?
Isoform G11P is also involved in phage assembly, probably playing a structural role in the formation of the phage assembly site.
What are the official names of this protein?
Gene 1 protein, G1P.
What is the protein family that this protein belongs to?
Belongs to the inovirus G1P protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: OR2V2_HUMAN
Sequence: METWVNQSYTDGFFLLGIFSHSTADLVLFSVVMAVFTVALCGNVLLIFLIYMDPHLHTPMYFFLSQLSLMDLMLVCTNVPKMAANFLSGRKSISFVGCGIQIGLFVCLVGSEGLLLGLMAYDRYVAISHPLHYPILMNQRVCLQITGSSWAFGIIDGLIQMVVVMNFPYCGLRKVNHFFCEMLSLLKLACVDTSLFEKVIFACCVFMLLFPFSIIVASYAHILGTVLQMHSAQAWKKALATCSSHLTAVTLFYGAAMFIYLRPRHYRAPSHDKVASIFYTVLTPMLNPLIYSLRNREVMGALRKGLDRCRIGSQH
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 2V2, Olfactory receptor 2V3, Olfactory receptor OR5-3.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: KGUA_SHEFN
Sequence: MSTRGNLFIVSAPSGAGKSSLISTLLKDKPSDKQVSVSHTTRKPRPGEVDGQHYHFITVEQFKALIAQNAFIEWAEVFGNFYGTSKLVIEQTLDKGIDVFLDIDWQGAEQVKKLMETAIGVFILPPSKAELERRLTGRGQDSQQVIDSRMAQAVSEMSHYAQYEFIIVNDDFDNALADLSAIIRSQRLTCASQQHAQNDMIVDLLAD
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPF_OCHNE
Sequence: MHLFTQTLVRFSSLIADGGVSFNPDIFETNVVNLAILTGGIFYLGSNALSESLVERQQKILGAIQEAEERLEQATERLKESKTQLEQAQLVIASIKEDAETTAKQVKSAILTEGKNEIERLTSAAKSQIVTIEAQVRKQISDYVVSLALQRVTLQLEGKLSDAAQQQILDRNISKLKD
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.