PharMolix/UniProtQA huggingface dataset:
Protein: FLOA_SYMTH
Sequence: MSMPGLGYLILTFVVLLLLVLFFSFVPVGLWISAAAADVRVGIFYMIGMKLRRVPPHRIVNALIKAEKAGLEISIDKLEAHYLAGGNVDRVIDALIAAQRAGIDLVFERAAAIDLAGRNVLEAVQMSVNPKVIETPVVAGVAQDGIELRAKARVTVRADINRLVGGAGEDTIIARVGEGVVSTIGSAASHKEVLENPDMISRTVLAKGLDAGTAFEIVSIDIADVDVGANIGARLRADQAEAEKVMAQAKAEERRAMAVAEEQEMRAETQRMRAKVVEAEAEVPRALAQALREGRIGVMEYLMMQNLQADTAMREALGGGQRGGQPGGQDQK
What is the function of this protein?
Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts.  FMMs are highly dynamic and increase in number as cells age.  Flotillins are thought to be important factors in membrane fluidity.
What are the official names of this protein?
Flotillin-like protein FloA.
What is the protein family that this protein belongs to?
Belongs to the flotillin-like FloA family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: RR11_CRUWA
Sequence: MAKPILRIGSRKNTRSGSRKNVRRIPKGVIHVQASFNNTIVTVTDVRGRVISWSSAGTCGFRGTRRGTPFAAQTAAGNAIRAVVDQGMQRAEVRIKGPGLGRDAALRAIRRSGILLSFVRDVTPMPHNGCRPPKKRRV
What are the official names of this protein?
30S ribosomal protein S11, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RLMD_CUPNH
Sequence: MSIDSLDMEARGVGRLLNEDGTPGKVIFVEGALPGETVSYRSFRRKPSYEQAHLVEVRQESVMRVKPGCQHFGVCGGCSMQHLDSRAQLAIKQRVLEDNLWHLSKVKPDVVFRPIAGPDWGYRYRARLTVRHVAKKGGVLVGFHERKSSYVADMTRCEILPPHVSAMLVPLRELVGGLSIRDRMPQIELAVGQEVTALVLRILEPLTDADKDLLRAFADQHKVQFWLQPKGPDTVYPFYPADAELAYTLPEFGIRMPFKPTDFTQVNHQINRVLIGRALRLLDAQPQDRLLDLFCGIGNFTLPLATQGKSVMGIEGSEALTTRALANAEYNGLAARTEFACRNLFEVTAEDIAALGRFDRWLVDPPREGALAVCKALGELAQQGSNVLPQRIVYVSCSPATLARDAGLLVHGAGYRLAGAGVVNMFPHTSHVESIAVFERG
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: LECB2_PSOSC
Sequence: SQTQSFNFNKFEQNK
What are the official names of this protein?
Basic lectin B2.
Protein: CBID_TRIV2
Sequence: MRSGYTLPVFACAGAIAALHWLRQRQSLQVGLVDLIEPAQMAEVPIEQVAGLSENMALAITRSDPGDNIDLTKNTPIWAVVEWGQGGGEQVTIKGGEGIGKQVNADNRAAIYSYAQRLLQANLTRLLAPEESIIVTIILPEGRSLAVRTSNSAFGVVEGLSLLGTTGISQPLSSPDQLDAFRSELQHKASLYASLVFCIGENGLDLARKIGINAEKLVKTANWLGPMLVEAEALGVKEILLFGYHGKLMKLAGGIFHTHHHLADGRREVLATHCALGGLSKQDIEIVFHAPTAEAALKHLKALDSSTGSDWVNQVYSAIAETIDSRCQEYMQSHSSRGTAATICGSILFDRDRKIIVKSKTACNLMGNLC
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: S26A7_RABIT
Sequence: LFSFKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPRGIPPPRAPPMNILSAVITEAFGVALVGYAASLALAQGSAKKFKYSVDDNQEFLAHGLSNVISSFLFCIPSAAAMGR
What is the function of this protein?
Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport.  May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger.  Plays a major role in gastric acid secretion (By similarity).
What are the official names of this protein?
Anion exchange transporter, Solute carrier family 26 member 7.
What is the protein family that this protein belongs to?
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
What are the subcellular locations of this protein?
Recycling endosome membrane; Multi- pass membrane protein. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion (By similarity).
Protein: BIOB_BURPS
Sequence: MTEAQTACATTETPVAAPAAPRWRVADVIALYELPFNDLLFRAQQTHREHFDANAIQLSTLLSIKTGGCEEDCGYCSQSAHHDTGLKAEKLMEVDAVLAAARTAKENGATRFCMGAAWRNPKDRHIEPIKEMIRGVKDMGLETCVTLGMLEEHQAKALAEAGLDYYNHNLDTSPEFYGQIISTRTYQDRLDTLERVRDAGINVCCGGIIGMGESRRERAGLIAQLANMNPYPESVPINNLVAIEGTPLENAQALDPFEFVRTIAVARITMPKAMVRLSAGREQLDDAMQALCFLAGANSMFYGDVLLTTGNPRAEADRKLLARLGMWASEASQLSA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: MRAY_ACTPJ
Sequence: MLVWLAEYLVQYNTAFNVVSYITFRAIMALLTAMGIGLWIGPEVIRRLQLLKFGQEVRNDGPESHFKKRGTPTMGGIMILIAIGVSTLLWADLRNSYVWFVLFVLFGYGAVGFVDDYWKIKRKNTDGLIARWKYFWLSVIALIAVFGIYAVGKDTAATQLVVPFFKDFMPQLGIFFIILSYFVIVGTSNAVNLTDGLDGLAIVPTIMVASAFALIAWATGNFNFAQYLHIPFVPNAGELVILCTAIVGAGLGFLWYNTYPAQVFMGDVGSLSLGGALGTIAVLVRQELLLVIMGGVFVVEALSVILQVGSYKLRQKRIFRMAPIHHHFELKGWPEPRVIVRFWIITLMLVLIGLVTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TECPR_DROME
Sequence: MPSFYLFAASSEGRVYTLSTNSGAWRELPYLGLEFKKICAVPNFLWAIGGDRQVYVHVHGLDVPIRIREESYENERWLPIEGFSKTLLPTDRYRYSSADGSVERGVDKIRLPSMAWQWDGDWHLDLELDGQPLTEDGWMYALDFPATYSAKKSWNSYVRRRKWVRYRRYAALNSWCAVAPLHKDPTQEPFIDVAIGGTCVPNAPAGTLCVWAITAHGRAMFRTGVSKTAPEGLRWTAVPTPTGSELAQISVGPTGLVWAVLHNGRVIVRTGVTRDNLVGDSWLDVKTPVAASSLRIVHVSVGTDAVWCVTNDHHAWFRRGVKGEAAGISEDSAIGKGWVEMVGNISMVSVAANDQVFAIGAADRCLYHRSGVTSADPTGKKWRLIQCPMQISRTSSSLSIVSRKSGGSSSTPGSKHQSFSNLYSKEKEKGVVETCAVIETVLNSSTGSCSSNGGPPGLLKNERWKLSADSPPTIGSLNLNDRHKQRTAALRETSHASSAPAADVVEVVTGKFETQLRNPRAWSPVRSVGSVVGTEAHPESDSTVFESDSTHHGSDVFLGEDDDHTGSQFWTECGILWSCVASGAVTVDASNMPNWFNEQTSDSKVDVNANWRKDIVNKLQRRQEKLAKLQTVAKFEKAVELSSWVKSADARYQRPGGEFEDCIIELEWVSSGSGTDTNSSENSRSGDSGTFTVLSPDGAATKIQFPLSDITCVQCCSEAGAPRIAIHAPHLPVNCSPVKLQFSSDSEMEDWLSHLSSVCSQINTMVGKPAGNAIWITSELGDVFVFDPANMKAHQTSEPSEGYVEKMDVSTCETPYYNTLYNGMPCGTELEISGCVYDDADQIRFDLQSHSAVKVQPHRVEKHRVIALHLNPRFNERTTVLNSMKESEWLDEIRNDKMAFAPGATFSLKIRALQDHYLIIVNNAVYTDYKYRIDPESVTRLYVSGRIKLFNVLYRCPSLIVSMERMHWRQMGGHIKRIFNSGVDVVWGISCDNTGWVYNGGWGGMFLKGLEGSGKINPMIDTHTYYVYENQRWNPISGFTAKSLPTDRHMWSDATGRQKRSKEHTKLLSTHCEWISDWAIDYNIPGGADKEGWQYAIDFPANYHAHKKLTDCVRRRRWMKRCRLSSSGPWQELSQSKILDAALQVLDEDVDHSCSGERNTAVAAWAIASNGDVLIRHGVCSLNPRGDAWEHITSDQPLVGISVGPTGQVWTVARNGMVFFRYGISRQNPCGDAWQQVEAPAGVTFKAISVGRAGIWALDNQQRLAVRKEISRTFPEGSHWQFLPNAANVPPHTDQHCGFRSVSVGSEVWAISLNGIICRRCGITEENPAGVGWNLGIAGQWQNVSVEGYM
What is the function of this protein?
Involved in peroxisome biogenesis.
What are the official names of this protein?
Tectonin beta-propeller repeat-containing protein, Peroxin-23 protein.
What is the protein family that this protein belongs to?
Belongs to the TECPR1 family.
Protein: DMR12_CRYX8
Sequence: MSSPIVLIFGAGANIGYNVAKEFVASGYKAVLTSRKAPTEPDASFSYVQGDLSDPKSVTDTFSQVRKQFGEPSVVVYNGNSKWHSNKEIAAAVSFTAKEDPFVVDLPTFEKDLNINTTSTFVAIKEALASFAALPETASRTFIYTGNAMNFLPFGGAMTLGAGKSASAHMIAAAAAAYAPKGYKFYYPDERQPDGRLGGRGISGEAHAKIYKKLSEDKTQGPWLQTFVKGTGYVSFPADTDVSVAH
What is the function of this protein?
Short chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of the dimeric xanthones cryptosporioptides (PubMed:30996871).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase dmx-nrPKS (Probable).  The atrochrysone carboxyl ACP thioesterase dmxR1 then breaks the thioester bond and releases the atrochrysone carboxylic acid from dmx-nrPKS (Probable).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase dmxR15, and oxidized by the anthrone oxygenase dmxR16 to yield emodin (Probable).  Emodin is then reduced to emodin hydroquinone by the oxidoreductase dmxR7 (Probable).  A-ring reduction by the short chain dehydrogenase dmxR18, dehydration by the scytalone dehydratase-like protein dmxR17 and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:30996871).  Baeyer-Villiger oxidation by the Baeyer-Villiger monooxygenase (BVMO) dmxR6 then yields monodictylactone in equilibrium with monodictyphenone (PubMed:30996871).  In the case of the cryptosporioptides biosynthesis, monodictylactone is reduced at C-12 to an alcohol (by the short chain dehydrogenases dmxR12 or dmxR8) and hydroxylated at C-5 by dmxR9, yielding the electron-rich aromatic which could eliminate H(2)O to form the ortho-quinonemethide, followed by tautomerisation to paraquinone and complete the formal reduction to produce the 10-methylgroup (Probable).  Conjugate addition of C-4a-OH to the resulting paraquinone by the monooxygenase dmxR10 then gives cyclohexadienone, which is then reduced at C-5 by the short chain dehydrogenase dmxR3 to give the dihydroxanthone (Probable).  The 6,7-epoxide in the cryptosporioptides could be introduced by the cytochrome P450 monooxygenase dmxL3 (Probable).  The highly reducing PKS dmxL2 manufactures butyrate, which is further carboxylated by dmxL1 to form ethylmalonate (PubMed:30996871).  It is not yet clear whether the carboxylation occurs while the butyrate is attached to the ACP of dmxL2, but this unusual fungal metabolite could then be esterified to O-5 by the O-acetyltransferase dmxR13 (PubMed:30996871).  Finally, dimerization performed by dmxR5 gives the observed dimers cryptosporioptides A, B and C as the final products of the pathway (PubMed:30996871).
What are the official names of this protein?
Short chain dehydrogenase/reductase dmxR12, SDR dmxR12, Dimeric xanthone biosynthesis cluster protein R12.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: ADAR_ASPNG
Sequence: MEQRSSPARSLPPRKTTTTPQLSCELCRKRKVKCDKLTPCTNCAASGTVCVPIYRTRLPRGRHATRPRRVSSPPPTSAPGETDRIIQPSVPVNEDLQERIYRLEALIQGMNSHSHTRTPSATSREQSVQLSDTSTFQTAPNPNTSPILNSSIVSKRLMLQRPDQFWADLVDEIHGLREVVESSLAGGQEGPIPSSDSAKSEPPNDDGIQVLGLGASNPSAALRSMSPLHNPVVARQLCEVYLQQVDPVIKILHRPSLNRWMVQGEPYLSYADGHPAVEALGSAVCYSAISSMTDNQCSVMFHANKADLLAEARVACETAIGRAGLLTTRDITVLQAFVLYLVARRSEDRTPAVWTLIALAVRIGKGLGLYLDPETETFFDQQIRRRLWFTICLMDLQASFGQASEPLISVDESASTALPQHINDSDFDPTTAAHSDPNREGLTDTTFALVTYHAQRTGRLLNFVQHDRKVDGGIPTPTSSTSGTSTSRSRTCDPSWPQQQARHFEQEALRLLHFCDPGTSAYAWFTWHGTQSLIATVRLAAARPLQWHGQAPPPRREGNTELLRLCLPVLEKAQLMHTDPRAEGFRWYVTIPWYALAMALAECYVSSDTALVRYAWPLVESSYLQYEATLGQSLGGPFGQLMRRMKEKLAAPAALPPSSLPSTNWSPATPPTFPGVPRPQSSHDDRHAPGCSWPVPTGSTPPADLGVPSLLPVSTWEALSPPSLDNPSLFGVPPTTTAVADGMDPGADIMWEELFSGIPFNEIAGPDTFFFDMNWGS
What is the function of this protein?
Transcription factor that specifically regulates the expression of the ada gene cluster involved in the biosynthesis of the linear tetracyclic TAN-1612 neuropeptide Y receptor antagonist.
What are the official names of this protein?
C6 finger domain transcription factor adaR, 2-acetyl-2-decarboxamidoanthrotainin biosynthesis cluster protein R.
What are the subcellular locations of this protein?
Nucleus.
Protein: MEP33_SCHPO
Sequence: MPPKKAAKGKGDPGKAAKKDPTKKAADATFGLKNKNRSTKVQAKIRQIEQNAAASGSKDAKRQEALRKRREEEKRAAEAAKAEVAALFNAIPKKQTPQNFLTRKEEVKESQKIDLYSDVRDQQTDLPLEKRPWINTDIVCKFFLEACETGKYGWLWQCPNGNMTCIYKHALPYGYVLSRDKKKDDTKEEISLEAFIEIERHRLGPNLTPVTEENFKKWSDGRRDRILKQAEERRSNRAVGRSNLSGREYFESNKDKTHEVVGDEEDWDFSALRRETEALAKAQDATAPIVSV
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC).  NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.  Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.  Involved in the export of mRNA from the nucleus to the cytoplasm.  May play a role in mitotic spindle formation and/or function.
What are the official names of this protein?
mRNA export protein 33.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCTA_PSEAE
Sequence: MIKSLKFSHKILLAASLVVFAAFALFTLYNDYLQRNAIREDLESYLREMGDVTSSNIQNWLGGRLLLVEQTAQTLARDHSPETVSALLEQPALTSTFSFTYLGQQDGVFTMRPDSPMPAGYDPRSRPWYKDAVAAGGLTLTEPYVDAATQELIITAATPVKAAGNTLGVVGGDLSLKTLVQIINSLDFSGMGYAFLVSGDGKILVHPDKEQVMKTLSEVYPQNTPKIATGFSEAELHGHTRILAFTPIKGLPSVTWYLALSIDKDKAYAMLSKFRVSAIAAALISIVAILVLLGLLIRLLMQPLHLMGRAMQDIAQGEGDLTKRLAVTSRDEFGVLGDAFNQFVERIHRSIREVAGTAHKLHDVSQLVVNASNSSMANSDEQSNRTNSVAAAINELGAAAQEIARNAADASHHASDANHQAEDGKQVVEQTIRAMNELSEKISASCANIEALNSRTVNIGQILEVIKGISEQTNLLALNAAIEAARAGEAGRGFAVVADEVRNLAHRAQESAQQIQKMIEELQVGAREAVATMTESQRYSLESVEIANRAGESLSSVTRRIGEIDGMNQSVATATEEQTAVVDSLNMDITEINTLNQEGVENLQATLRACGELETQAGRLRQLVDSFKI
What is the function of this protein?
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation.  Major receptor that responds to all naturally occurring L-amino acids, except L-Gln and L-Asp.  Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate (PubMed:16233808, PubMed:23650915, PubMed:8522505, PubMed:9353923).  Also mediates chemotaxis to histamine, but does not bind histamine (PubMed:30425146).  In addition, binds the quorum-sensing signal autoinducer 2 (AI-2), thus inducing chemotaxis toward AI-2 and biofilm formation (PubMed:33097715).
What are the official names of this protein?
Methyl-accepting chemotaxis protein PctA.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RS16_PECAS
Sequence: MVTIRLARGGAKKRPFYQVVVTDSRNARDGRFIERVGFFNPIATGQAEALRLDLDRIEHWLGLGATVSDRVSSLIKDAKKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: G3PA_SINAL
Sequence: DREGAGKHIQAGAKKVLITAPGKGDIPTYVVGVNAELYSHEDTIISNASCTTNCLAPFVKVLDQKFGIIKGTMTTTHSYTGDQRLLDASHRDLRRARAAALNIVPTSTGAAKAVALVLPNLKGKLNGIALRVPTPNVSVVDLVVQVSKKTFAEEVNAAFRDAAEKELKGILDVCDEPLVSVDFRCSDVSSTIDSSLTMVMGDDMVKVIAWYDNEWGYSQRVVDLADIVANNWK
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic, NADP-dependent glyceraldehydephosphate dehydrogenase subunit A.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GCSP_SHEB8
Sequence: MTKQTLTQLEQHDLFLRRHIGPDSNQQQAMLNFVGAESLEDLTAQIVPESIRLSQDLSIGDSCGEAEGIAYIRGLADQNQVFKSYIGMGYYGTQVPNVILRNVFENPGWYTAYTPYQPEIAQGRLEAILNFQQVSMDLTGLDLASASLLDEATAAAEAMALAKRVSKAKKANIFFVADDVFPQTLDVVKTRAECFGFEVVVGPANEAVNYELFGALFQYTNRFGQITDFTELFATLRAKNVIVTVAADIMSLVLLKSPGSMGADVVFGSAQRFGVPMGFGGPHAAFFVARDEHKRSMPGRIIGVSKDARGNRALRMAMQTREQHIRREKANSNICTAQILLANMASFYAVFHGPDGLKTIASRINRFADILAAGLQAKGVSLVNSTWFDTISIKGLDVAAVNARALAAEMNLRFDADGTVGVSLDETTLRTDIEALFDVILGADHGLDVAALDAQIVSQGSQSIPAALVRQDAILSHPTFNRYQSETEMMRYIKRLESKDLALNYSMISLGSCTMKLNAAVEMLPVSWPEFANMHPFSPLDQAKGYTQLIEELSTWLVNITGYDAVCIQPNSGAQGEYAGLLAIKKYHESRGDAHRNICLIPQSAHGTNPASAQLAGMQVVVTACDKQGNVDLEDLKTKAAEVAGNLSCIMITYPSTHGVYEESIREICDIVHQHGGQVYLDGANMNAQVGLTSPGFIGADVSHLNLHKTFAIPHGGGGPGMGPIGVKSHLAPFVAGHVVVKPGRESDHNGAVSAAPYGSAGILPISWMYIKLLGSQGLKKSTQTALLNANYVMKKLSEHYPVLFRGRNDRVAHECIIDLRPLKEASGVTEMDIAKRLNDYGFHAPTMSFPVAGTLMIEPTESESKVELDRFIDAMVSIRAEIAKVESGEWPVDNNPLHNAPHTMADIMDPEFDTRPYSREVAVFPSAAVRTNKFWPTVNRIDDVYGDRNLFCACVPLSDYE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: GMEB2_RAT
Sequence: MATPDVSVHMEEVVVVTTPDTAVDGSGVEEVKTVLVTTNLAPHGGDLTEDNMETENAAAAACAFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQYDEHVISPKEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKIDLSGARVSLSSPTSTEYIPLTPAAADVNGSPATITIETCEDPGDWTTTIGDDTFAFWRGLKDAGLLDEVIQEFQQELEETMKGLQQRVQDPPLQLRDAVLLNNIVQNFGMLDLVKKVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELKHKSQHLSNVLMTLTPVSLPSPMKRPRLARATSGPAAMASQVLTQSAQIALGPGMPMSQLTSVPLGKVVSTLPSTVLGKGSPQAAPASSPASPLLGGYTVLASSGSTFPSTVEIHPDTSSLTVLSTAAMQDGTTVLKVVSPLQLLTLPGLGPTLQNVAQASPAGSTIVTMPTAAATGPEEHTATIEVAAVAEDHEQK
What is the function of this protein?
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids.  Binds also to the transferrin receptor promoter (By similarity).
What are the official names of this protein?
Glucocorticoid modulatory element-binding protein 2, GMEB-2.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Protein: LMF1_HUMAN
Sequence: MRPDSPTMAAPAESLRRRKTGYSDPEPESPPAPGRGPAGSPAHLHTGTFWLTRIVLLKALAFVYFVAFLVAFHQNKQLIGDRGLLPCRVFLKNFQQYFQDRTSWEVFSYMPTILWLMDWSDMNSNLDLLALLGLGISSFVLITGCANMLLMAALWGLYMSLVNVGHVWYSFGWESQLLETGFLGIFLCPLWTLSRLPQHTPTSRIVLWGFRWLIFRIMLGAGLIKIRGDRCWRDLTCMDFHYETQPMPNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLGRRACIIHGVLQILFQAVLIVSGNLSFLNWLTMVPSLACFDDATLGFLFPSGPGSLKDRVLQMQRDIRGARPEPRFGSVVRRAANVSLGVLLAWLSVPVVLNLLSSRQVMNTHFNSLHIVNTYGAFGSITKERAEVILQGTASSNASAPDAMWEDYEFKCKPGDPSRRPCLISPYHYRLDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLLAHNPFAGRPPPRWVRGEHYRYKFSRPGGRHAAEGKWWVRKRIGAYFPPLSLEELRPYFRDRGWPLPGPL
What is the function of this protein?
Involved in the maturation of specific proteins in the endoplasmic reticulum.  Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway.  Each LMF1 molecule chaperones 50 or more molecules of LPL.
What are the official names of this protein?
Lipase maturation factor 1, Transmembrane protein 112.
What is the protein family that this protein belongs to?
Belongs to the lipase maturation factor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: COAX_CUPTR
Sequence: MNAPRLLVDIGNTRLKWAWCEAGAPLPASTGTTVLPTPWQHAGAVAHAADGALRTLAAELRALRAGGPMPSVWISNVAGPVIAAAVDAALADAFGGCAPVQWVRSAAAHGDLVNGYREPTQLGVDRWVGAVGAHRWLPRDTLLVVTAGTATTLDIVTVAAEGGARFEGGLILPGLALMLGTLARNTAQLPALDVGEAGSVAGAQRRWADNTHDAIAAGCLAAQAGAIERTWRALGERGDAARPPRCLLSGGARGALAGALAVPFEMHDNLVLLGLHAMAMADA
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRYAA_TAPIN
Sequence: MDIAIQHPWFKRTLGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSPEDLTVKVQEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQTALSCSLSADGMLTFSGPKVPSGLDAGHSERAIPVSREEKPSSAPSS
What is the function of this protein?
Contributes to the transparency and refractive index of the lens.  Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.  Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
What are the official names of this protein?
Alpha-crystallin A chain.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Protein: ENY2_HUMAN
Sequence: MVVSKMNKDAQMRAAINQKLIETGERERLKELLRAKLIECGWKDQLKAHCKEVIKEKGLEHVTVDDLVAEITPKGRALVPDSVKKELLQRIRTFLAQHASL
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes.  The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B.  The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription.  Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879).  As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).
What are the official names of this protein?
Transcription and mRNA export factor ENY2, Enhancer of yellow 2 transcription factor homolog.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Note=Localization at the nuclear pore complex requires NUP153 and TPR.
Protein: SRGT1_ARATH
Sequence: MRWDLITAIVAALVVSVLADESGQMAPYRIHTLFSVECQNYFDWQTVGLMHSFLKSGQPGPITRLLSCTDDQKKTYRGMNLAPTFEVPSWSRHPKTGDWYPAINKPVGVLYWLQHSEEAKHVDWVVILDADMIIRGPIIPWELGAERGRPFAAHYGYLVGCDNLLVRLHTKHPELCDKVGGLLAMHIDDLRVLAPLWLSKTEDVRQDTAHWTTNLTGDIYGKGWISEMYGYSFGAAEAGLKHKINDDLMIYPGYVPREGVEPVLMHYGLPFSIGNWSFTKLDHHEDNIVYDCNRLFPEPPYPREVKIMEPDPSKRRGLILSLECMNTLNEGLILRHAENGCPKPKWTKYLSFLKSKTFMELTRPKLLAPGSVHILPDQHEPPPIDEFKGTYPKIHTLFSTECTTYFDWQTVGFMHSFRQSGQPGNITRLLSCTDEALKNYKGHDLAPTHYVPSMSRHPLTGDWYPAINKPAAVVHWLHHTNIDAEYVVILDADMILRGPITPWEFKAARGRPVSTPYDYLIGCDNDLARLHTRNPEACDKVGGVIIMHIEDLRKFAMYWLLKTQEVRADKEHYGKELTGDIYESGWISEMYGYSFGAAELNLRHSINKEIMIYPGYVPEPGADYRVFHYGLEFKVGNWSFDKANWRNTDLINKCWAKFPDPPSPSAVHQTDNDLRQRDLLSIECGQKLNEALFLHHKRRNCPEPGSESTEKISVSRKVGNIETKQTQGSDETKESSGSSESEGRFSTLKLWVIALWLISGVGFLVVMLLVFSTRRGRGTTRGKGYRNKRRTSYSNTGFLDTK
What is the function of this protein?
Glycosyltransferase involved in the O-galactosylation of several proteins including extensins.  Catalyzes the transfer of alpha-galactosyl to Ser residues.  Hydroxylation of proline residues adjacent to the serine acceptor is required for activity.
What are the official names of this protein?
Peptidyl serine alpha-galactosyltransferase, AtSGT1.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.