PharMolix/UniProtQA huggingface dataset:
Protein: PYRB_METTP
Sequence: MLKRRHVLSMKDFSREEIDEILETAESLEPYARGKGSDILEGKILALMFFEPSTRTRMSFETAMKRLGGKTINLGSAEASSIAKGESLADTIRVVGGYADAIVIRHPKEGSARLAAEFSPVPVLNAGDGAGHHPTQTLLDLYTIKKESHLDDLSIALVGDLKYGRTVHSLAYALSLYGADIYLVSPPTLRMPEQIIGDLSRMGTRVREVSDLREVIKEVDVLYITRIQRERFPDPVEYNRVARSYSITIRDLEGVKPELRIMHPLPRVDEISPSVDETEHAVYFRQSFYGVPVRMALLKMILED
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: MIA40_GIBZE
Sequence: MYRNTMRSASRPVIASLRSSTIRAAPRRFASTAPADKPRSFKGSLVRLGLAFGAVYYYNTSPIFADEAISKTVPAPAAFSDDDLPTVDSIVEEKRKQIKAKSEETAASSKTPESQQSNPQTAAADGSPAALEEEAGQQGAFNPETGEINWDCPCLGGMADGPCGEEFKTAFSCFVFSQEEPKGMDCIDKFQGMQECFKKYPDIYGAELADDEDGAPTPDFGDEQPSGEPTTAEVKSNGELARETKDKTAADATKFDDSQKPAESKTPAKTTSTSTDSAQKPAVDAHRDAEPKSDAETASSGSRMVQDVAIPIEKPVNDKYWQDMHKSEVQKKEVTVGITQAHDATAANEEIKHIERQEAAKKNAEKKQ
What is the function of this protein?
Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS).  Forms a redox cycle with ERV1 that involves a disulfide relay system.  Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria.  The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
What are the official names of this protein?
Mitochondrial intermembrane space import and assembly protein 40, Mitochondrial import inner membrane translocase TIM40.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass type II membrane protein; Intermembrane side.
Protein: NS1_I79A3
Sequence: MDSNTITSFQVDCYLWHIRKLLSMRDMCDAPFDDRLRRDQKALKGRGSTLGLDLRVATMEGKKIVEDILKSETDENLKIAIASSPAPRYITDMSIEEISREWYMLMPRQKITGGLMVKMDQAIMDKRITLKANFSVLFDQLETLVSLRAFTDHGAIVAEISPIPSMPGHSTEDVKNAIGILIGGLEWNDNSIRASENIQRFAWGIRDENGGPPLPPKQKRYMARRVESEV
What is the function of this protein?
Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1.  In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm.  Cellular protein synthesis is thereby shut off very early after virus infection.  Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: SPAT4_MOUSE
Sequence: MAAAGQAEECLPLPAAESSKTSLPTPPAVPAGKKPKKCLVYPHPPRSSRLSRSVLRWLQGLDLSFFPRNVTRDFSNGYLVAEIFCIYYPWDLRLSSFENGTSLKVKLDNWAQIEKFLAKKKFKLPKELIHGTIHCKAGVPEILIQEIYTLLTHQEIRSIQDDLANFTDYIYQMRLPLVPRNTVSKSIKNNIRLSELLSNPNVLSNELKIEFLILLQMLQRKLSRKLNPGWFDVKPTVGEITIDRLPAHSYKRRYKSRGSKEKAAQPLSKSDNDGNARKEIHVKQSGNPCENTENL
What is the function of this protein?
May play a role in apoptosis regulation.
What are the official names of this protein?
Spermatogenesis-associated protein 4, Spermatogenesis-related gene 2 protein, Testis and spermatogenesis cell-related protein 2, Testis spermatocyte apoptosis-related gene 2 protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROA_ECOBW
Sequence: MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQAA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBPA_YERPN
Sequence: MRNSDLAPLYRSAIGFDRLFNLLESGQNQSNGGYPPYNVELVDENNYRIAIAVAGFAEQELEITTQDNLLIVRGSHANEPAQRTYLYQGIAERNFERKFQLAEHIKIKGANLVNGLLYIDLERLVPESLKPRRIEIK
What is the function of this protein?
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress.  Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE.  Its activity is ATP-independent.
What are the official names of this protein?
Small heat shock protein IbpA, 16 kDa heat shock protein A.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDLS_CORJK
Sequence: MGESKQEHLIVGVSPFNPRFTPEWLSSAFQWGAERFNTVDVLHPGEISMSLLTSTGTPLGRAKRKVRQQCNRDMRNVEHALEISGIKLGRGKPVLISDYLQTQSYQCRRRSVIAEFQNNQIFQDACRAMSRAACQSRLRVTNVNIEPDIETAVKYIFDELPAYTHCSDLFEYETAALGYPTEWPIGKLIESGLTSLERDPNSSFIVIDFEKELIDD
What is the function of this protein?
It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP-independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways.  Catalyzes the formation of cyclo(L-Leu-L-Leu) (cLL) from L-leucyl-tRNA(Leu).  Can incorporate various nonpolar residues, such as L-leucine and L-methionine, into cyclodipeptides.
What are the official names of this protein?
Cyclo(L-leucyl-L-leucyl) synthase, Cyclodileucine synthase, Cyclodipeptide synthase, CDPS.
What is the protein family that this protein belongs to?
Belongs to the CDPS family.
Protein: NDHI_OBLMI
Sequence: MFPMVPEFMNYGQQTVRAARYIGQGFMITLSHANRLPVTIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, chloroplastic, NAD(P)H dehydrogenase subunit I, NDH subunit I, NADH-plastoquinone oxidoreductase subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: ASXL2_CHICK
Sequence: MREKGRRKKGRTWAEAARTVLEKYPNTPMSHKEILQVIQKEGLKEIRSGTSPLACLNAMLHTNSRGEEGIFYKVPGRMGVYTLKKDVPDGLKELSDGSEESSDAQSDSQSSENSSSSSSSDGCTNKDGRKSRWKRKVSSRLSQTSSPQTSCQSPSIQTGKVISSSQKHSKKALKQALKQQQQKQQQQQCRAGMPVSSNQHTLLKAVKAASASTPTKPAWIGKQSDGHSNSSQNSTFSSSASVKLDNSLPGLGKKPFQRSDRLHARQLKRTKCAEIDVETPDSILVNTNLRALINKHTFSVLPTECQQRLLLLLPEVDRQVGADGLMKLSGSALNNEFFTSAAQGWKERLSEGEFTPEMQLRIRQEIEKEKKVELWKEHFFESYYGQSSGLSPEESERLTANTSADDGEAEKPAAEQPKCMQVKEEITSPSESKAQVVQEAPAVKKGEERRVEERREEMQPKAAKPAEASVSPAGCAVKPSNPQIQERIQGEPIQENPQPAVSQKLEEERKHTASKEVKEAVRAPVLAPSKPKSPEAGEAAAKVTSPVVVPPTPEKKPPVNEEMEVSVEGHKRKSESSEEALTTPGKKPRIAEKCQQQQPAFRSQTQSFPAAGPPVPRVPPLKIPVSRISPMPFPAGQVSPRVRFPASLISPARTGARTLADIKAKAQQVRAQRAAAAAAAAAASSGGAVPGPGPGGGPAGGGGTGNAATSGAGETGTRGNALELAGTGSGGSSRRFLPRCPGTHSPMETQEQPATPSLSRAQLQQTSVLQSRSAAGNTGTNCSSPAVSAIEQISGIKQSPPNVAINQVSGSSCAGGCDKQEKAPSAPAGLGQACGASTVRDGTTCVTVSSADSNANITRVAPAALGGTSSDVPKGTSPSPLMPSLTPTSSEAQAGGAVVSAPSAPCSNTLSAAPSLKTHPSSSGALPKANSSIPANNPLVTQLLQGKSVPLEQILPKPLTKAEMKTVPLASNEEKGAAVPGVAGSGAGAEGGERQSALSPQQLGKIFCQSRPLPHIPRTFVLPAGKEPGADQHPEALSKTTQEQILQTLIKRVQRQNLLPVLQPSQVNVAHSGFQLENSSTSQRFVLGFMGRRTSKPAMSGHYLLNISTYGRGSESLRRGFSLNPETRSCLNSPAGGPKAECGECEEMPDHGSSSEEEDADNESTGDEHEHVSVKEEPQASQVAAPCEKEQVSHGANSSDYGILAKKGVKTEAAVSQQAAGSRENSQALDGTALARDFIQAAQEQTVHAVKGKTHSSPELFSSSTPSSDSAQLQLPQLSHPHPPKLGGDAAAAQLIGPSYSGTINVSTSPDVNQGSLMSGLSECNQLSSSMGNVMSFSVTVTTIPTSQAMNSGNHSQTIPVQAFAEDSSMEDSPSKCYCRLKAMIMCKGCGAFCHDDCIGPSKLCVSCLVVR
What is the function of this protein?
Putative Polycomb group (PcG) protein.  PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development.  PcG proteins are not required to initiate repression, but to maintain it during later stages of development.  They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility.  heritably changed in its expressibility.  Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors (By similarity).
What are the official names of this protein?
Putative Polycomb group protein ASXL2, Additional sex combs-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the Asx family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MNMG_RHOBA
Sequence: MTANNPQNRYDYDVVVIGAGHAGTEAAAAAARLGAKTALLTTNLDTVGQMSCNPAIGGVAKGQIVREVDALGGLMGEAIDATGIQFRMLNRRKGPAMHSPRAQADKKAYQNFIKYRIETQDNLDLRQETVEDLITEPIADGQDRLANQRVIGVRVRGDAVYHAPTVILTTGTFLQAIMHTGKSQSAGGRAGEGTTAGLSGALKGMGFTLDRFKTGTPPRLNARTIDYSGLEEQPGDDDPQPFSYLNDAISSPQMACHIAHTNERVHDLIRANLDRAPMYSGQIDSRGPRYCPSIEDKVVRFADKSSHQLFLEPEGRQTCEVYVNGISTSLPRDVQDAMFRCIPGLEKAAIMRYGYAVEYDYCPPTQLWPHLESKSVSGLFFAGQINGTTGYEEAAGQGLIAGLNAARTAASKTPWVPSRQDAYIGVLVDDLVTSGTDEPYRMFTSRAEYRLLLRQDNADRRLTAQADELGLIDAARRERFHRKLAEIERGTELLQQAKFQPETGPTVRGDVYLRRPEVTWNVIAEQVPELAGIGREAAEQCSIDIKYAGYIDRQQAEVHKQSRHAEKSIPVSFDYDKIGPLRNEAKEKLTKVRPLNLGQAKRISGITPADLALVLAHLENNSLSQTKSSASVDKRASSDNESSRPTSSASDSL
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSPG7_DICDI
Sequence: MATIFDILNTLNNNNFENCKRQCSTNKSNKTIIDILPPMDVTMTNDKLIIETELAGISKDQIEIDIKDSILTIQGEKKKNLNKQQQQLVIEKSSTSPSSSTLDSKENGPSIEEFEDDIKPKSTTSTTTVSTATTTKENKEDENKTKSSDKKFISERSFGNFKRYLDLTKVLYQLDLNSINTQFENGLLTITINKKLHYSNTIKININ
What are the official names of this protein?
Small heat shock protein hspG7.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: DNAA_BACFR
Sequence: MSESSHVGLWNRCLEIIRDNVPESTYKTWFVPIVPLKYEDKTLIVQVPSQFFYEFLEDKFVDLLRKTLYKVIGDGTKLMYNVLVDKSSGATVNQESTTRSTAIPQSGLPRVDERKAPGLLRAPAVQDLDPHLNPNYNFETFIEGYSNKLSRSVAEAVAENPAKTVFNPLFLHGASGVGKTHLANAIGTRIKELYPDKRVLYVSAHLFQVQYTDSVRNNTTNDFINFYQTIDVLIIDDIQEFAGVTKTQNTFFHIFNHLHQNGKQLILTSDRAPVLLQGMEERLLTRFKWGMVAELEKPTVELRKNILRNKIHRDGLQFPSEVIDYIAENVNESVRDLEGIVISIMAHSTIYNKEIDLDLAQRIVRKVVRCETKAVTIDDIINVVCKHFDLESSAIHTKSRKREVVQARQVAMYLAKTHTDFSTSKIGKFIGNKDHATVLHACKTVKGQCEVDKGFRSDLENIETLLKKRNVSNGER
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLND_ECO45
Sequence: MNTLPEQYANTALPTLSGQPQNPCAWPRDELTVGGIKAHIDTFQRWLGDAFDNGISAEQLIEARTEFIDQLLQRLWIEAGFSQIADLALVAVGGYGRGELHPLSDIDLLILSRKKLPDDQAQKVGELLTLLWDVKLEVGHSVRTLEECMLEGLSDLTVATNLIESRLLIGDVALFLELQKHIFSEGFWPSDKFYAAKVEEQNQRHQRYHGTSYNLEPDIKSSPGGLRDIHTLQWVARRHFGATSLDEMVGFGFLTSAERAELNECLHILWRIRFALHLVVSRYDNRLLFDRQLSVAQRLNYSGEGNEPVERMMKDYFRVTRRVSELNQMLLQLFDEAILALPADEKPRPIDDEFQLRGTLIDLRDETLFMRQPEAILRMFYTMVRNSAITGIYSTTLRQLRHARRHLQQPLCNIPEARKLFLSILRHPGAVRRGLLPMHRHSVLGAYMPQWSHIVGQMQFDLFHAYTVDEHTIRVMLKLESFASEETRQRHPLCVDVWPRLPSTELIFIAALFHDIAKGRGGDHSILGAQDVVHFAELHGLNSRETQLVAWLVRQHLLMSVTAQRRDIQDPEVIKQFAEEVQTENRLRYLVCLTVADICATNETLWNSWKQSLLRELYFATEKQLRRGMQNTPDMRERVRHHQLQALALLRMDNIDEEALHQIWSRCRANYFVRHSPNQLAWHARHLLQHDLSKPLVLLSPQATRGGTEIFIWSPDRPYLFAAVCAELDRRNLSVHDAQIFTTRDGMAMDTFIVLEPDGSPLSADRHEVIRFGLEQVLTQSSWQPPQPRRQPAKLRHFTVETEVTFLPTHTDRKSFLELIALDQPGLLARVGKIFADLGISLHGARITTIGERVEDLFIIATADRRALNNELQQEVHQRLTEALNPNDKG
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: IF1C_JASNU
Sequence: MKEKEAKWVVEGLVTEGHPSGMFRVQLDNGARVLGYISGKIRRKAIRIMQGDRVQIELSHYDLTKGRIIYRLPPPPIPKPKDSEDDSED
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BST1C_YARLI
Sequence: MWVAYSPIEGLTTEHSRLAEKYSLYLVKSTPYDIPLPVRPSGVPVLFVPGNAGSYRQIRSISDTCRELNEQYGGSEIDFFALDFNEAYSALHGRTLLDQAEYLNDAINYILQMYRDNGKDVSSVMLLGHSMGGVVSRLAISLDNYKPGTVTTIFTLASPHLVPPATFDGDIQKVYNRMNDFWRSNYADSDNNSLSDMTVLSIAGGKRDTMVPSDYISLDSVVPSSHGLSTFSNSINRVWTGIDHDAMMWCHQLRRQIAIALMNVIDRDVNGRMEVFRKVFSGTQTLSDAEEDFEDVEVTPVKHGLHQKLESGWYYGENVQVMTTHTVNQESAFESYEMSSGSLLRAFECRSKSGSSFKGCRKIFPLLVPGSNDAVIAFAETEHYLLLDVSSSSDWISIDQVSQKSASFDFVTGATISTSNTISTDISFPKLTSGLVSYKVSVSKGVQLVRQYVQQNSSRVYDSKYLVPHNGVVDVSFHGDVPFVPYFQSSPLHLQVFGGGHVTIRVDWIGSLGNLFMRYRILFISLPSAILYAIFLVQFHAGTARFLSLRQSTSIFINRYLLTSCLAGSGIAYLTGLSQVRDFLHLIQIPITKTFAVDPSYTKNDLFLGLSGVSGTVLAPIFTVFSTGMVVLITELVMGLTSLLSFCFKSTTTAQSESESGDPISDLLHKRTVFVAVISVLVLLFFPYQLAFTLATVALLVMTAYFKSNKAPQEQSFNNYISTICVLMTWTCIINAPVLAVWIQGIVVQRSMTFSSHHNLVSILPTLLFVENLSFRRIPSGSSITSLLLAYTSLHCLFYGMMQAFMIHHGFNLLATWLLCMSYKKVFFKSKHE
What is the function of this protein?
Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
What are the official names of this protein?
Putative GPI inositol-deacylase C.
What is the protein family that this protein belongs to?
Belongs to the GPI inositol-deacylase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RNAS2_PAPHA
Sequence: MVPKLFTSPICLLLLLGLMGVEGSLHAKPGQFTWAQWFEIQHINMTSGQCTNAMLVINNYQRRCKNQNTFLLTTFADVVHVCGNPSMPCPSNTSLNNCHHSGVQVPLIHCNLTTPSRRISNCRYTQTTANKYYIVACNNSDPVRDPPQYPVVPVHLDRVI
What is the function of this protein?
This is a non-secretory ribonuclease.  It is a pyrimidine specific nuclease with a slight preference for U.  Cytotoxin and helminthotoxin.  Possesses a wide variety of biological activities (By similarity).
What are the official names of this protein?
Non-secretory ribonuclease, Eosinophil-derived neurotoxin, RNase UpI-2, Ribonuclease 2, RNase 2, Ribonuclease US.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Lysosome. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
Protein: RS6_LISMH
Sequence: MARKYEIMYIIRPNIEEDEKKAVVERFDGILTENGAEIIESKEWGKRRLAYEINDYRDGFYHIVKLNADKADSINEFDRLAKISDDIIRHMVIKEEA
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: CD4_RABIT
Sequence: MNRRIYFQCLLLVLPLALLPAATWGKTVVRGKAGAIVELPCQSSQKRNSVFNWKHANQVKILGNQGSSSSSFWLKGNSPLSNRVESKKNMWDQGSFPLVIKDLRMDDSGTYICEVGDKKMEVELLVFRLTANPNTRLLHGQSLTLTLEGPSVGSPSVQWKSPENKIIETGPTCSMPKLRLQDSGTWSCHLSFQDQNKLELDIKIIVLGFPKASATVYKKEGEQVEFSFPLNFEDESLSGELMWQVDGASSAQSWVSFSLEDRKVSVQKILPDLKIQMSKGLPLSLTLPQALHRYAGSGNLSLTLDKGKLHQQVSLVMLKVTQVKNKLTCEVLGPIDPKMKLSLKLEDQEAKVSTQKMVQVLDPKAGTWQCLLSSGDQVLLESKADVLATGLSHQQPTLLAGALGGTAGLVLFAGLCIYCCVKCRHRRHQAQRMSQIKKLLSEKKTCQCPHRLQKTYNLL
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex.  The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells.  In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway.  Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
What are the official names of this protein?
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts.
Protein: ABRX1_HUMAN
Sequence: MEGESTSAVLSGFVLGALAFQHLNTDSDTEGFLLGEVKGEAKNSITDSQMDDVEVVYTIDIQKYIPCYQLFSFYNSSGEVNEQALKKILSNVKKNVVGWYKFRRHSDQIMTFRERLLHKNLQEHFSNQDLVFLLLTPSIITESCSTHRLEHSLYKPQKGLFHRVPLVVANLGMSEQLGYKTVSGSCMSTGFSRAVQTHSSKFFEEDGSLKEVHKINEMYASLQEELKSICKKVEDSEQAVDKLVKDVNRLKREIEKRRGAQIQAAREKNIQKDPQENIFLCQALRTFFPNSEFLHSCVMSLKNRHVSKSSCNYNHHLDVVDNLTLMVEHTDIPEASPASTPQIIKHKALDLDDRWQFKRSRLLDTQDKRSKADTGSSNQDKASKMSSPETDEEIEKMKGFGEYSRSPTF
What is the function of this protein?
Involved in DNA damage response and double-strand break (DSB) repair.  Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1.  The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs.  This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
What are the official names of this protein?
BRCA1-A complex subunit Abraxas 1, Coiled-coil domain-containing protein 98, Protein FAM175A.
What is the protein family that this protein belongs to?
Belongs to the FAM175 family. Abraxas subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: BFR2_CRYNJ
Sequence: MSGLSLAQQLKQLHSNNVSVPDPESAYSNLDSHDIQRKGDEGREHYVDVGPSRLRMELGGTGGGTLTGPKYEGVKTGRMKIFDDDDDDDDDREGNGSEEGSDGEGDEDEDGDEDDEDEEDEDEDEEESDEDEQGEDEDEDEEEQPQPRANGSKQALDPVASLRNSRLKDVEKGQAIRKQKALFESLITLRITFQKALTASNTVPPTLPEDPENELAYKKASILKSLGELNERLFTLRESISLPGELGEDVSLGKRKRAEGDDAQGQAYWIKAAKESLGIADRSHPQLLPILNKWSSKIQAASLQLGSKQAGGSKFLQQMKNGAGGVVEAIESGINSKREAEKTLMESEETGYRALLREVIESRSGSGPAADLTHLRREKKKKREAERGGSKGRKLRYTVHEKAQNFVVPIPLSHGWHEEQVDELFSSLFGGVGMKGATAEKTVGLDVGTADEGLAELGGLRVF
What are the official names of this protein?
Protein BFR2.
What is the protein family that this protein belongs to?
Belongs to the AATF family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: CH601_MYCSJ
Sequence: MSKQIEFNETARRAMEIGVDKLADAVKVTLGPRGRNVVLAKSWGGPTVTNDGVTIAREIDLEDPFENLGAQLVKSVATKTNDVAGDGTTTATVLAQALVRAGLRNVAAGANPIALGAGISKAADAVSEALLAAATPVDDKSGIAQVATVSSRDEQIGELVGEAMTKVGHDGVVTVEESSTLNTELEVTEGVGFDKGFISAYFVTDFDSQEAVLEDALVLLHREKVSSLPDLLPLLEKVAEAGKPLLIIAEDVEGEALSTLVVNAIRKTLKAVAVKAPFFGDRRKAFLDDLAVVTGGQVINPDVGLVLREVGLDVLGTARRVVVTKDSTVIVDGGGSADAIADRAKQLRAEIEATDSDWDREKLEERLAKLAGGVAVIKVGAATETDLKKRKEAVEDAVSAAKAAVEEGIVTGGGAALVQARKALDSLRGSVSGDEALGVEVFNSALSAPLYWIATNAGLDGSVVVNKVSELPAGQGFNAATLEFGDLLADGVVDPVKVTRSAVLNAASVARMVLTTETAIVDKPAEEEDHGHGHHHGHAH
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLH32_HUMAN
Sequence: MPSERCLSIQEMLTGQRLCHSESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLTSLSEEQIWQLAVRWLEHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAPYFTCPNLQTLQVPHHRIGTI
What are the official names of this protein?
Kelch-like protein 32, BTB and kelch domain-containing protein 5.