PharMolix/UniProtQA huggingface dataset:
Protein: CYAY_NEIM0
Sequence: MMTESEFIRASEALFEHIEDQIDENGWDFDCRFAGNVLTIEAGDGTQIIVNRHTPNQELWIAAKSGGYHFAEQNGKWLATRDSRDFYDVLNEALSAASGEAVEIAEL
What is the function of this protein?
Involved in iron-sulfur (Fe-S) cluster assembly.  May act as a regulator of Fe-S biogenesis.
What are the official names of this protein?
Iron-sulfur cluster assembly protein CyaY.
What is the protein family that this protein belongs to?
Belongs to the frataxin family.
Protein: FUJ1_GIBF5
Sequence: MGSQISEKYYAREPIAIVGTSCRFPGGASSPSKLWELLDNPRDVVQKIPPRRFSTEAFYNADSQHHGVSPSDLIKGLRLTLQWSTNVKHAYLLDDDPRGFDRDFFAINPKEAEAMDPQQRILLETVYESVESAGYSIEQLRGSSTAVFVGCMSFDYQFAAIRGIDSTLPQYHATGAAMSILANRVSYFYDWKGPSVAIDTACSSSLVALHQAVSALRSGDAKLAVAAGSNLILGPEPFISESKLNMLSPNGRSYMWDASADGYTRGEGFSVLLLKTLTKALADSDHIECVIRETGVNSDGKTPGITMPSSNAQAQLIRDTYAKCGLDPNRESDRPQFFEAHGTGTQAGDPIEARAIQEVFFPDHTQPTDSKLLVGSVKTVIGHTEGTAGLAGVLKATLAIQHSQIPANLHFNELNPKIRPYYDNLRIPTETTPWPTLSPGAPRRVSVNSFGFGGTNAHAIVESWDGPYVRERSPAPNAIGAGPFVLSANSSQALAANAGALAEYLKEHPTTNLGQLGYTLFKRTNLPFRAAFSGSSVECLVEKLQAGKESLKSNSRITTLPESLPPRVLGVFTGQGAQWAKMGEGLYQTSMVFRNSVEQMQHSLDSLPESDRPNWTLAEQLHAPKETSRVGQATVSQPLCTAIQVALVDVLHVVGVELSAVVGHSSGEIGAAYAAGYLSAGDAIRIAYYRGFHSHLAQGPGGKRGSMMAVGLSYDQALSFCNELSGGITVAASNSYTSCTLAGDAEVIEEAKSRLEENGTFARVLAVDTAYHSHHMKPCATPYLESLKQCDIQVQKPKKGCAWYSSVWGSDGSSRSFNTEGELLQGQYWIENLTHPVLFSQALARALNEDQCFDCALEVGPHPALKGPSLEIIKTLTGVSLPYSGVLKRGEGAAEAFADALGLLWKSFPSSRPTITFNGICRAFSAVKPSSMTILKNLPNYSWDHATLFWKESRASRNFRTPKHAPHELLGRSVSHGEHSRREVHWRQVMRLRELPWLRGHKIQGEILFPASGYLSMAYEAAIRLVDEQQSVRIVEMQDMDIVRAMRLEDDTSGLEVLFTIHVTSQSQSCINANVACYSGAVDAPQPLDAHQTELTAHFNGRIRLWLEQPSAYTLPLRSEPLLPMSELNMAQVYSSLSKEGFDYSGDFQAKSMLRRLGHTVVTLSSPSPVSWTHTLTHPAPIDTAVQGLLTAFSFPGDGRIGTTYLPTRIESVRISTAPSESDAPILKADSVVTLTDVTTITGDVDIFDAASCHTQVQMRGVQMTAIGKPPDRWLYAGKIWARDIAYGLEPGSGTQFSDDDRLLYEQLVRTAYFYLRQLRSKIRPPELMLMGKFRRHMMRWVTEHLFPQIESGQHPDIRTEWKDDTLDTVQRWRNSRPADNNDMNLLHAMGQSLIPIVRGTVPPLKVLVQDGMLDRLYFEGIGFRDGNVDLGAIVKQLGHEHPRMRIVEVGAGTGGTTRTVLDALETRYAAYTYTDISTGFFENARSVFSQHASKLTFKTLNIENDPVDQGFTEGSFDMLIASNCLHATHSLENTLRQCRKLLRPGGRLVLLEITRDFLPIQMIMATLPGWFLGMDEGRLWAPTVTLDRWDEILKTTGFSGVDISSTPSYCSVIVSQAVDETVSVLRNPLASPDGVPSLSEIVIIGGVGSGLAPQIQSLLTSTIPVETRIASSLEDVEVNRGSTVLCLGDLDSPSFCNMDQTRFEGLQKVFQAANAVLWVTSGATSGTNPEANITVGMGSTLMAERGDLKLQFLDVDDPTTIDPSMLARMLLRLAILDQSKSDETLWTIEPELTLKNGALYIPRVQPLDVINRQSTARYRQVIEDIDLNSASPVVDLVKYQDSWKLQSSPIDSTRVNGIEVRVTASSLHTLSCEGGKPEYIFMGRELLSGDNIIGLSASNSSIANITDDQVLHRWQDSQTGAINVAQLSDLLAKALAENLLRNTTGPVWIHGAPSNLSEAIGEVTKEEGLDVFQTTSDLAQVAAFNFIHPYATRQDIQDKQPSGLRNFVDLEHSELRNEALHTSVAASLPVSAISHRCMMDLTHGINRSYLAKLAARCLTEDRKSSEDHSQVILIDRIASESSKDLGPTTVIDWHAANTVTALVRPLEHRDLFFPSKSYLLFGMTGDLGISVCKWMVDNGARNVVLASRNPNVPSSVLNFMSRKSATVRALSVDITDMESLCTAREDIESTMPPIGGVMNAAMVLRDRLFHDLTWEDFAAVLGPKVQGTQNINNAFGQKESALDFFVCFSSATSIIGTVGQSAYAAANHFMVSLVQQRKRRGLAGSIVHISVLTGLGYIFRRGSEHTAVIDKALLPRLERQAETDLHEMLAEAIVCGRPGSSQPPELITGIKAVFQGEWRDDPRLLGYLGQQQLGNDSAKDQAAGMVSVETQLDAADDPAECLPILEKRFAQALGNMLEIDPEKVDGSMPVASLGIDSLVAIRIREWFMKELGVEVPVLKIMSVGHSLSRVCDDVLVDWRRVKKEGELEDKK
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fujikurins A-D, secondary metabolites playing a role during rice infection (PubMed:23825955, PubMed:26192387).  The polyketide synthase PKS19 acts with the trans-enoyl reductase FFUJ_12240 and the polyketide transferase FFUJ_12241 to produce fujikurins, however, the biosynthesis pathway has not been identified yet (PubMed:23825955, PubMed:26192387).
What are the official names of this protein?
Polyketide synthase 19, PKS19, Fujikurins biosynthesis cluster protein PKS19.
Protein: ELP4_BOVIN
Sequence: MAAAGTCGTGTRSTGSMVAAASTNNVTSFQRRGPRASGADSGCSRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQKLPAPLIDDSYKKECDEDVCSHKMEPDIKMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQNKAVIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNLIYDISDVKDLAFKLKKKLFTIERLHLPPDLSDTVSRSSKQDLAESTKLLGPGCGMTAGGKKHLDF
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).  The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
What are the official names of this protein?
Elongator complex protein 4.
What is the protein family that this protein belongs to?
Belongs to the ELP4 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HEM1_DEIRA
Sequence: MPQPAPLDFVVVGLNHQTAPVEVRERVAVRPEEEGALLGHLARHADEVLLLATCNRTEVYLAGVHGDPLAAFEGAWGHALLDHLYVYRGEAAVRHLYRVTAGLDSLVIGETQIQGQVKRAWQSARERGLSGTLMNKVVQGALAAGKRVRSHTGLSDKVVSVSSAAVELAQAALGELSQRRALILGAGETAELTLTHLRAAGVQDVLVVNRTAERARALAEKLGGRACPAEELSAALPEVDVVIASSAAPHYVVTAQNVREALAGRPGRAMFLIDISVPRILDPEIASVPGAHLYNLDDLTAVVQRNMQSRRAALPQAEAIIRELGSDLSRWYLTRETQLARQAELALACD
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: ULK3_XENLA
Sequence: MAAGWAPPRLEDFILTEKLGSGSYATVYKAYRKRNAREVVAIKCVSKKSLNKAAVENLLTEIEILKTVHHPHILELKDFQWDQDYIFLITEYCAGGDLSRFIRTRRILPERIVQVFLQQLASALKFLHEKNISHLDLKPQNILLSRLDRPHLKLADFGFAQHMSSEDAPQALRGSPLYMAPEMVCSKHYDARVDLWSVGVILYEALFGKAPFASKSFSELEEKILSHKTIELPTRPRLSPECRDLLQQLLQRDPDKRISFIEFFAHLFVDLEHMPSAETLEKATRLVVEAVEKDSAGEHSAALTLYCKALEYFIPALHYESDAKRKEAMRSKVCQYISRAEELKVLVSSSNKTLLMQGISGRELLKEMAQDKPRLFSALEVASAAVAKDEEGCACDALDLYQQSLGELLLMLSAESPGRRRELLHAEIQTLMGRAEFLKEQMKTSQWKSESLGQEVLSESVRNSCSLQ
What is the function of this protein?
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.
What are the official names of this protein?
Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSRQ_ASPN1
Sequence: MPAPAEVQAATLEKFIQGWAGWTPDGFLANWSEDCTQKTLPFSSGVPLRTRADTEKLFPVLMSLMSNFTLDIHNVVHDAPQGKAVIYALTKADTPFGPYRNEHAIFLWFNEIGDRVQKIEEMFDAVVMQEFLPKLDKYVADNKMQLGAKFS
What is the function of this protein?
Monooxygenase; part of the gene cluster that mediates the biosynthesis of the tetrahydroxanthone dimer neosartorin, which exhibits antibacterial activity (PubMed:30394754, PubMed:32105084, PubMed:33891392).  The two different monomeric units appear to be synthesized by the same set of enzymes, among which the Baeyer-Villiger monooxygenase nsrF is the key enzyme for the divergence of the biosynthetic routes (PubMed:32105084).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase nsrB (PubMed:32105084).  The atrochrysone carboxyl ACP thioesterase nsrC then breaks the thioester bond and releases the atrochrysone carboxylic acid from AacuL (PubMed:32105084).  Atrochrysone carboxylic acid is decarboxylated by the decarboxylase nsrE, and oxidized by the anthrone oxygenase nsrD to yield emodin (PubMed:32105084).  Emodin is then reduced to emodin hydroquinone by the oxidoreductase nsrR (PubMed:32105084).  A-ring reduction by the short chain dehydrogenase nsrJ, dehydration by the scytalone dehydratase-like protein nsrI and probable spontaneous re-oxidation, results in overall deoxygenation to chrysophanol (PubMed:32105084).  The Baeyer-Villiger monooxygenase nsrF accepts chrysophanol as a substrate to insert one oxygen atom at two different positions to yield the precursors of both monomric units (PubMed:30394754, PubMed:32105084, PubMed:33891392).  NsrF is promiscuous/flexible in interacting with the 2 (non methylated and methylated) aromatic rings of chrysophanol, thus diverging the biosynthetic pathway at this point (PubMed:30394754, PubMed:32105084, PubMed:33891392).  After the hydrolysis of the lactones, methylesterification by the methyltransferase nsrG yields respectively moniliphenone and 2,2',6'-trihydroxy-4-methyl-6-methoxya-cyldiphenylmethanone (PubMed:30394754, PubMed:32105084).  The next steps are the hydroxylation by the FAD-dependent monooxygenase nsrK, followed by isomerization by the monooxygenase nsrQ (PubMed:32105084).  The short chain dehydrogenase/reductase nsrO then catalyzes the C-5 ketoreduction to give the xanthone skeleton of blennolide C and 5-acetylblennolide A (PubMed:32105084).  The acetyltransferase nsrL has a strict substrate specificity and uses only blennolide A but not blennolide C to yield 5-acetylblennolide A as the single-acetylated product (PubMed:30394754).  In the final step of the biosynthesis, the heterodimerization of the 2 xanthones, blennolide C and 5-acetylblennolide A, is catalyzed by the cytochrome P450 monooxygenase nsrP (PubMed:30394754).  NsrP can utilize at least three different xanthones as its substrates to perform the dimerization reaction (PubMed:30394754).
What are the official names of this protein?
Monooxygenase nsrQ, Neosartorin biosynthesis cluster protein Q.
What is the protein family that this protein belongs to?
Belongs to the avfA family.
Protein: GTAB_STAAM
Sequence: MKKIKKAIIPAAGLGTRFLPATKAMPKEMLPILDKPTIQYIVEEAARAGIEDIIIVTGRHKRAIEDHFDSQKELEMVLKEKGKSELLEKVQYSTELANIFYVRQKEQKGLGHAISSARQFIGNEPFAVLLGDDIVESEVPAVKQLIDVYEETGHSVIGVQEVPEADTHRYGIIDPLTKNGRQYEVKKFVEKPAQGTAPSNLAIMGRYVLTPEIFDYLKTQKEGAGNEIQLTDAIERMNNDNQVYAYDFEGERYDVGEKLGFVKTTIEYALKDDSMREELTRFIKALGL
What is the function of this protein?
Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP.  This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i. e.  the predominant glycolipid found in the S. aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).
What are the official names of this protein?
UTP--glucose-1-phosphate uridylyltransferase, Alpha-D-glucosyl-1-phosphate uridylyltransferase, UDP-glucose pyrophosphorylase, UDPGP, Uridine diphosphoglucose pyrophosphorylase.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 2 family.
Protein: GSA_METST
Sequence: MKLDKSKELFDEAVNYLPGGVNSPVRAYKPYPFFAKSAKGSKIYDVDGNEYIDYCLGYGPLLFGHANEHIIEKSIEQLKLGTDYGVPSEKEVQLAKEVIKRVPCAQMVRFTNSGTEATMSAIRLARGITKRDKIIKFEGAYHGAHDAVLVKSGSGAAGLPDSPGIPTDTTKNTMLVEFNDEEALKKLINENKDEIACIIVEPVMGNIGCVPPKEGYLDFLREITLENGILLIIDEVITGFRISKGGAQEYYNVIPDLATFGKIVGGGFPIGAIAGKKEYMEQFTPSGKIYQAGTFSGNPMSINGGLAAFEVLDDNSYKQLHKSGEYFRNGIVDILDKLNINFHVNGVESMTQIYFTENEVYDYKTAQTSDTENFLKYFHLLLENGVFIAPSQYECGFISTSHSRDDLDKTLNAIEIALTKLYK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEDB_PEDAC
Sequence: MNKTKSEHIKQQALDLFTRLQFLLQKHDTIEPYQYVLDILETGISKTKHNQQTPERQARVVYNKIASQALVDKLHFTAEENKVLAAINELAHSQKGWGEFNMLDTTNTWPSQ
What is the function of this protein?
Imparts immunity to pediocin PA-1/ACH to naturally sensitive host strains.
What are the official names of this protein?
Pediocin PA-1 immunity protein, Pediocin ACH immunity protein.
Protein: ACTPE_ACTFR
Sequence: SADVAGAVIDGAGLGFDVLKTVLEALGNVKRKIAVGIDNESGRTWTAMNTYFRSGTSDIVLPHKVAHGKALLYNGQKNRGPVATGVVGVIAYSMSDGNTLAVLFSVPYDYNWYSNWWNVRVYKGQKRANQRMYEELYYHRSPFRGDNGWHSRSLGYGLKSRGFMNSSGHAILEIHVTKA
What is the function of this protein?
Pore-forming toxin (PFT) that consists of a crown-shaped octamer or nonamer that forms cation-selective hydrophilic pores of about 1. 5 nm (inside) and 13 nm (outside) and causes cytolysis (By similarity).  It causes cardiac stimulation (By similarity).  Also causes hemolysis (HC(50)=1. 6 nM) (PubMed:31295915).  Interestingly, the Phe-16 is crucial for hemolysis (By similarity).  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers (By similarity).  It is probable that a dimeric form is an assembly intermediate before the complete oligomerization (By similarity).  The formation of stable pores occurs only in vesicles composed of DOPC/SM (there is no oligomerization when the PFT is treated with vesicles of DOPC or SM alone) (By similarity).  The transmembrane pore displays 8 lateral perforations, one at each subunit-subunit interface, partially occupied by the acyl-chain region of a bridging lipid (By similarity).  Each pore contains 24 lipid molecules, firmly bound to each subunit, that is, 3 lipids (L1, L2, L3, L4 and/or L5) are associated to each subunit (By similarity).  Lipid L1 bridges 2 subunits, whereas lipids L2 and L3 bind to sites at single subunit (By similarity).
What are the official names of this protein?
DELTA-actitoxin-Afr1e, DELTA-AITX-Afr1e, Alpha-helical pore-forming toxin, PFT, Cytolysin, Fragaceatoxin E, fraE.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: UPP_MYCGA
Sequence: MKNFIFNHPLISDKLSKMRDVNTGYNFFKQLLTEITTLMMYEVGKGYELEEISVTTPLATTKAHKLKHNFVIVPILRAGLGMVDGVHNVIPTARVGHIGLYRDEKTFQPVEYYSKFPQTMDDGHVIVLDPMLATGASVIKAISLVKNIQPKKPRSIKFMGLLGAPEGLKALNQAHPDVDVYLACLDEKLNDKNYIYPGLGDAGDRIFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: SSRP_FERNB
Sequence: MRIIATNKKAYTDYIIDETYEAGIVLVGTEVKSLREHGASFKDSFCRVKEGEIWLLNLHIPPYQHGNIYNHDPERPRKLLLHKKEIDRIWSKLKLEGYTVIPTKIYFNNQGKVKVEIAIAKGKKSYDKREEIKKKETQKRIKEYLKYNR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MOAC_PELPD
Sequence: MNFNHFDESGNAVMVDVSHKQPTLRTAVAAARVGMSPELLAAIREGGMAKGDVLGVARLAGIMAAKKTPDLIPLSHPLAIHSVAVDYELDSGAGTIQVRCTVRALERTGVEMEAMTGASLAALTIYDMCKGSDKSITIGDIRLLYKEGGKSGVYRREEGQ
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: EFUK_HORCR
Sequence: MTIHSPWETSHSKKGLIDIGTHRLFARVSGPRRKPGDPVILIECGGGSISLLWTGVMRALSPTYRIFTYSRAGLEGSDLPPNRGPRTAVEMADDFEKLLDVAGIKSPYIIVGHSYAGVQIRTWMHVHDRMEDIVGAVFVDTATEYTYPRMPIREPQFWFLMEQIPNPAHVLGYDRVHKFFNKEQWEEVLSTDLGHEEKDVDASAAQLKTWKQFERQIMEDKPVSVIKGYFAEDLRRLCVEAERIGAGTPAQRQYVMENLDSLDRVFEETETEQLRLSSCARMVHAAPGSGHTIVFSDPEIVMNEIKWVVEQYEAKRSIATIKGDLSNITAPPFLLASQSTCEFPSYWAEHPSIFVAPALEPDPKKRALLVLRWFLAALKRQQYAGRDEKEGVKKPLNAFLGELFFAQWQDQSGTTKLVSEQVSHHPPITACYLWNDEHGVRADGFACQSITFSGTVNIKQMGHAILHIDKYDEDYLIPLPNVKVQGLLTGTPYPELVGSYQIACSSGFVADIDFSGKKLFGMSGTKNMLHAALYSADDKQRENPIYTIEGAWNDKFTIRDESTGENVETYDTAANPATILEVAPLDLQDPWESRKAWGETISSLNGGKMQGASDAKSKVEQGQRAMRKQDEQNGSKWEPVFFSNEPRDERYIRLTAVAGTSTEEHSQSGFWKFDKDRAERARKPYHGSLRPDNVES
What is the function of this protein?
Probable transporter; part of the gene cluster that mediates the biosynthesis of enfumafungin, a glycosylated fernene-type triterpenoid with potent antifungal activity, mediated by its interaction with beta-1,3-glucan synthase and the fungal cell wall (PubMed:30051576).  Might be involved in transport of enfumafungin to and across organelle membranes (Probable).
What are the official names of this protein?
Probable transporter efuK, Enfumafungin biosynthesis cluster protein K.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
Protein: BIOD_ALTMD
Sequence: MKQYFVTGTDTEVGKTYVTCQLLRAANNASLTAIGYKPIAAGCELVNGEWVNEDALNIQQASACANGQTLPINEINPIALTPPIAPHIAANEEGVALTHEKIAEGLNALAAYRPDILLMEGAGGWRLPLTIGSDNTPTHYLSDVVKALKMDVILVVGMRLGCLNHALLTAEAIRADGLIIKGWVANDITGNMTRYQENLRSLKAMLPEPLLAEIPYQTGIEAGTLLSAIEQLS
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7S_MOOTA
Sequence: MPEEEQLTFEAALQKLEEVVQALEGEGLTLEDSLAYYQEGIRLVRLCRQRLKEVEGKLQVILLQDGEVVTRELSLPGGENHGT
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYE_STAAS
Sequence: MSDRIRVRYAPSPTGYLHIGNARTALFNYLYAKHYNGDFVIRIEDTDKKRNLEDGETSQFDNLKWLGLDWDESVDKDNGYGPYRQSERQHIYQPLIDQLLAEDKAYKCYMTEEELEAEREAQIARGEMPRYGGQHAHLTEEQRQQFEAEGRQPSIRFRVPQNQTYSFDDMVKGNISFDSNGIGDWVIVKKDGIPTYNFAVAIDDHYMQISDVIRGDDHISNTPKQIMIYEAFGWEPPRFGHMSLIVNEERKKLSKRDGQILQFIEQYRDLGYLPEALFNFIALLGWSPEGEEEIFSKEEFIKIFDEKRLSKSPAFFDKQKLAWVNNQYMKQKDTETVFQLALPHLIKANLIPEVPSEEDLSWGRKLIALYQKEMSYAGEIVPLSEMFFKEMPALGEEEQQVINGEQVPELMTHLFSKLEALEPFEAAEIKKTIKEVQKETGIKGKQLFMPIRVAVTGQMHGPELPNTIEVLGKEKVLNRLKQYK
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIE1_BOVIN
Sequence: MVWLEPPLLLPIFFLASHVGAAVDLTLLADLRLTEPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPRPWQPPHIARNGSSRVTVRGFSQPSDLVGVFSCVGGGGTRVLYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVRKEKQTDVIWKSNGSYFYTLDRHEAQDGQFLLQLPNVQPSSSGIYSATYLEASPLGSAFFRLIVRGCEAGRWGQDCTKECPGCLHGGVCHDQDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTSGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGRFGADCHLQCQCQNGGTCDRFSGCVCPSGWHGMHCEKSDRIPQILDMVSELEFNLDTMPRINCAAAGNPFPVRGSMELRKPDGTVLLSTKAIVEPDRTTAEFEVPRLALGDSGLWECRVSTSGGQDSRRFRINVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPIASVRLHYRPQDSTMAWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLKPWLEGWHVEGPDRLRVSWSLPPVPGPLVGDGFLLRLWDGARGQERRENVSSPQARTALLTGLTPGTYYQLDVRLYHCTLLGPASPAARVLLPPSGPPAPRHLHAQALSDSEIQLMWQRPEAAAGPISKYIVEVQVAGGSGDPLWMDVDRPEETSTIVRGLNASTRYLFRVRASVQGPGDWSNVVEQSTLGNGLQIEGPVQEIHAAEEGLDQQLVLAVVGSVSATCLTILAALLTLACIRKSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLNYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQAYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
What is the function of this protein?
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
What are the official names of this protein?
Tyrosine-protein kinase receptor Tie-1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: ATPH_CHAVU
Sequence: MNPLISAASVIAAGLAVGLSSIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL24E_HALS3
Sequence: MVQTRSCDYCGDDIEPGTGTMFVHNDGSTVHFCSAKCEKNADLGREPRDVEWTDEEEVEETQ
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL24 family.
Protein: ACDA_METSH
Sequence: MKNVQINIGAVVKEEDEWDQEMGPFPKPGVATLRDWDFKICNRYKIMYSPADDTCTLCTYGPCDLTGNKKGACGIDMAAACGKIVLVAVLMGTCAHTAHGRHLYHWCLDKFGDMPFDMGSEILVDAPLYRTILGKKPKSLKDFGEALEYCEEEIVQLLAACHTGQEGHYMDFESKSLHSGMIDSLGKEICDMLQTVAYDMPRGAADAPLVEIGMGTLDQNKGVLIAYGHNLAAGAEAMIYTEEHNLWDKVDIGGVCCTAIDLTRITETGRESKIPANLGPKAKVAGAMGWWRKMVRAGIMDTVIVDEQCVFCDVLEDCQQRHIPVIASNDKIMLGLPDRTNDSADAIVEDLVSFKMPGVAILDPVKAGEVAIRTAVAVKPKREQYKKESLFTEQQFKDTLATCTECNQCAFVCPPHIRISEMISEALKGNLEPFSSTYEVCVGCQRCEQTCPQEIPILKLYEYANREYIRNQKFKMRAGRGPVLDTEIRKVGAPLVLGQIPGVIALVGCSNYPNGTKECYDIAKEFVDRGYIVVATGCMAMDMSLYKDEDGKTIWEQYEGAFDGRNICNIGSCVANAHIHGAAIKVATIFAHRNERANYDDIADYIMSKVGACGVAWGAYSQKAASIATGVNRIGIPVVVQPSSVIYRRTFMGRTDKPEDWMVIDAKNGNMQQIEPAPEAMLYIAETKEEAMLEMAKLCFRPSDNTQGRGIKLTHYCDISMKYFGKLPDDWHLFVRDVKDLPLNYQTQMMKELEEKHGWKIDWKAKKFISGPLRPADVSFDPTNIPRKIRAKK
What is the function of this protein?
Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).  The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
What are the official names of this protein?
Acetyl-CoA decarbonylase/synthase complex subunit alpha, ACDS complex subunit alpha, ACDS complex carbon monoxide dehydrogenase subunit alpha, ACDS CODH subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the Ni-containing carbon monoxide dehydrogenase family.