PharMolix/UniProtQA huggingface dataset:
Protein: BDB_BRECH
Sequence: MRAKWLWMTAVGSLLITVLTAWGWAAASSQDSKIVYVFSDSCGYCQTFRPTLETVLQEYPQTSVERLDIREERDLKEALRLGAEATPTIFVVRDGTVMDKLEGDVAEAVLRSFFQKKS
What is the function of this protein?
Stimulates the oxidation and reduction of disulfide bonds in vitro.
What are the official names of this protein?
Disulfide bond formation protein, Disulfide oxidoreductase, Thiol-disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Secreted. Note=Is found associated with the cell lysate, thought to be associated with the cell periphery.
Protein: PNP_PSEFS
Sequence: MNPVIKKFQFGQSTVTLETGRIARQASGAVLVTVDDDVTVLVTVVGAKTADPSKGFFPLSVHYQEKTYAAGKIPGGFFKREGRPSEKETLTSRLIDRPIRPLFPEGFMNEVQVVCTVVSTSKKTDPDIAAMIGTSAALAISGIPFDGPIGAARVAFHESTGYLLNPTYEQQKASSLDMVVAGTSEAVLMVESEAKELTEDQMLGAVLFAHDEFQVVINAVKELAAEAAKPTWTWAPQPEATALLGAIRSEFGAAISDAYTITVKADRYARLGELKDQVVAKLSGEEGQPSSSEVKAAFGEIEYRTVRENIVNGKPRIDGRDTRTVRPLNIEVGVLPKTHGSALFTRGETQALVVATLGTARDAQLLDTLEGEKKDPFMLHYNFPPFSVGECGRMGGAGRREIGHGRLARRSISAMLPAADVFPYTIRVVSEITESNGSSSMASVCGASLALMDAGVPMKAPVAGIAMGLVKEGQKFAILTDILGDEDHLGDMDFKVAGTAKGVTALQMDIKIKGITEEIMEIALGQALEARLNILGQMNQIIGQSRTELSENAPTMIAMKIDTDKIRDVIGKGGATIRAICEETKASIDIEDDGSIKIFGETKEAAEAARQRVLGITAEAEIGKIYVGKVERIVDFGAFVNILPGKDGLVHISMLSDARVEKVTDILKEGQEVEVLVLDVDNRGRIKLSIKDVAAAKASGV
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_PROMT
Sequence: MARRFLLEFEKPLVELENQIDQIRELARDSEVDVSQQLLQLETLAARRREEIFNALTPAQKIQVARHPQRPSTLDYIQMFCDDWVELHGDRNGTDDQALIGGLARIGEKSVLLIGQQKGRDTKENVARNFGMAKPGGYRKALRLMDHADRFNLPIISFIDTPGAYAGLIAEEQGQGEAIAVNLREMFRLKVPIIATVIGEGGSGGALGIGVADRLLMFEHSVYTVASPEACASILWRDAGKAPEAASALKITGPDLMKLGIVDEVLKEPSGGNNWAPLQAGDTLKNALEKHLSELLALSPDELRNNRYSKFRKMGKYLESQSIESEISV
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEBF_SHIFL
Sequence: MKKRGAFLGRLLVSACASVFAANNETSKSVTFPKCEGLDAAGIAASVKRDYQQNRVARWADDQKIVGQADPVAWVSLQDIQGKDDKWSVPLTVRGKSADIHYQVCVDCKAGMAEYQRR
What are the official names of this protein?
Protein YebF.
What is the protein family that this protein belongs to?
Belongs to the YebF family.
What are the subcellular locations of this protein?
Secreted.
Protein: THAS_RAT
Sequence: MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
What is the function of this protein?
Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation.  Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage.  12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2.  Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.
What are the official names of this protein?
Thromboxane-A synthase, TXA synthase, TXS, Cytochrome P450 5A1, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: KRF2_COLLI
Sequence: MSCCNPCVPCQPCGPTPLANSCNEPCVRQCQSSTIAIQPSPVVVTLPGPILSSFPQNTVVGSSTSAAVGSILSCEGVPINSGGFDLSCITSRYCGSRCRPC
What are the official names of this protein?
Feather keratin Cos1-2, F-ker.
What is the protein family that this protein belongs to?
Belongs to the avian keratin family.
Protein: PDPFL_HUMAN
Sequence: MASVPSIGCLLARNQYYRKSSVSSVSSLTSSDSVNFIDDDKPQQGLPEVAESTWWFKSFFHSEPVLSNVRIKDLSATGSLSGRS
What are the official names of this protein?
Pancreatic progenitor cell differentiation and proliferation factor-like protein, Exocrine differentiation and proliferation factor-like protein.
What is the protein family that this protein belongs to?
Belongs to the PPDPF family.
Protein: BL1S4_KLULA
Sequence: MMSENITAVEPQENNDVEADSDPFNIDKLIVDYDYLLYKIQDELESIQLKTLEICQKQNEIVEHGIIEEVIDGNIGMAKDLLQKCDDLEKHYDQLDAVEGIVVSFKSRLKGVITQYKKYIDTKK
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit CNL1, BLOC-1 subunit CNL1, CNO-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S4 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Punctate pattern.
Protein: MGSA_CLOAB
Sequence: MNSKKKIALVAHDNRKKALISWCEANSEVLSNHSLCGTGTTAKLIKEATGLEVFPYKSGPMGGDQQIGAAIVNEDIDFMIFFWDPLTAQPHDPDVKALLRISVLYDIPIAMNESTAEFLIKSPIMKEQHERHIIDYYQKIRKDNF
What is the function of this protein?
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
What are the official names of this protein?
Methylglyoxal synthase, MGS.
What is the protein family that this protein belongs to?
Belongs to the methylglyoxal synthase family.
Protein: ACT2_XENLA
Sequence: MCDDDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETAYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility.
What are the official names of this protein?
Actin, alpha skeletal muscle 2, Actin alpha 2, alpha2, alpha2p.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: LSPA_BURO0
Sequence: MAKTLSKPASGALAPWLGISLIVILFDQLSKIAILKTFAYGAQHALTSFFNLVLVYNRGAAFGFLSTASGWQRWAFTALGVGATLVICFLLKRHGHQRLFSVSLALILGGALGNVIDRLVYGHVIDFLDFHLGAWHFPAFNLADSAITVGAVLLIYDELRRVRGAR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
Protein: RL30E_THEKO
Sequence: MVDFAFELRKVQDTGKIVMGAKKSIHLAKVGGAKLIIVARNARPDIKEDIYYYAKLSGIPVYEFEGTSVELGTLLGRPHTVSALAVIDPGESKILALAGGKE
What are the official names of this protein?
50S ribosomal protein L30e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL30 family.
Protein: SRBS1_RAT
Sequence: LNRDDDSDLHSPRYSFSEDTKCDDGWFVGTSRRTK
What is the function of this protein?
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor.  Required for insulin-stimulated glucose transport.  Involved in formation of actin stress fibers and focal adhesions (By similarity).
What are the official names of this protein?
Sorbin and SH3 domain-containing protein 1, Ponsin, SH3P12.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Nucleus matrix. Note=Colocalized with PXN at focal adhesions during myogenic differentiation. Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions.
Protein: SPT2_SCHPO
Sequence: MAGTPSFQKLMALADSQSAQAAVQIEQLRKAQIREKAREITEERNRQRKLQRERELRQKYEEEQRRQQAMEAKRIAASTRQTSERPPLSAEEAKRIREVKEKDRLESKKNERQGKPRSYNELLRQASSAPAVNETSSSGLLQSKDKRSQSPHSPKKPVKNSSSRDQPVRNSGATSTASLPPAGLRAGRGSQISASLAWLKTGGASAAPSNPRQPPPTSNFSNRKARYASNGLVQLQTGPKRDKRSAGEVQDEIMKRRQNSSISQAATPRTVSNSETSYVGSPALKQSKPNSLKSNNTSRKTSASSAITKPKARPHTSRHDEFVVSDDDELNDRVPDVSSEIWKIFGKRKQDYVSRDVFSDEDDMEATGHDVWREEQAAARAARLEDELEEQRERERELAKKRRKNK
What is the function of this protein?
Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin.  Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription.  Global regulatory protein that plays positive as well as negative regulatory roles in transcription.
What are the official names of this protein?
Protein spt2.
What is the protein family that this protein belongs to?
Belongs to the SPT2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNAA_RUMCH
Sequence: MNVQLNEIWNRTLELLKGEMTEISFNTWILTIEPISIDSNTITLGVPADFNKGILEARYSYLIKNALRQISHRDYNIYFAIPSQTPVKPVAQEYTEDSNMSFLNPKYTFDTFVIGNGNRFAHAASLAVAEAPAKAYNPLFLYGGVGLGKTHLMHAIGHFVLSQNPALKVLYVSSEKFTNELINAIRDDKNEEFRYKYRNIDVLLIDDIQFIGGKERTEEEFFHTFNALYEANKQIIISSDKPPKEIPTLEDRLRSRFEWGLIADIAPPDLETRIAILRKKAQLENLDVPDDVMVFIADKVASNIRELEGALNRVIAYSTLTENIINVDMAVEALKDMLNNSKAIIINSKTIQEAVARYFHLKTDDLKSKRRSRDVSFPRQIAMYLCRDMTDMSLPKIGDEFGGRDHTTVIHACEKINNDLNNSTELKRTVEEIKKNITGG
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LECA_VICSA
Sequence: SVTSYGLSAVVPLKDVVPEWVRIGFSATTGAEYAAHEVLSWSFHSELGGTSS
What are the official names of this protein?
Mitogenic lectin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the leguminous lectin family.
Protein: KATG2_BURO1
Sequence: MSNEGKCPFNHGKRNGTTNRDWWPNQLNLKILHQHSSEADPMDPGFDYAEAFNSLDLAAVKADLRALMTASQDWWPADFGHYGPFFVRMAWHSAGTYRTGDGRGGAGRGQQRFAPLNSWPDNVGLDKARRLIWPVKQKYGRKISWADLIVLTGNVALESMGFKTFGFAGGREDSWEPDEDVYWGMESTWLDDKRYSGDRQLETPLAAVQMGLIYVNPEGPNGNPDPLASARDIRETFARMAMNDEETVALIAGGHTFGKTHGAGDASHVGPEPEAAPLEQMGLGWKSSFGSGKAGDAIGSGLEVIWTSTPTQWSNNFFWNLFGYDWELTKSPAGAHQWQPKGGAGADSVPDPFEPGKRRVPTMLTSDIALRADPTYEKISRRFFENPNEFAEAFARAWFKLTHRDMGPRVRYLGPEVPSEELLWQDPIPMPDHPQVDEQDVSALKAKVLASGLSVSELVSTAWASASTFRGSDKRGGANGARVRLAPQKDWEVNQPAQLATVLEVLGALQVEFNRAATGGKQVSLADLIVIAGNAGVEQAAAAAGVEITVPFTPGRGDASAEQTDVDSMAVLEPIADGFRNYLKGAYTIPAEKLLIDKAQLLSLSAPEMTVLIGGLRVLGTNVGDSKHGVFTDRREVLTNDFFRNLLDMGTEWKPTSEANEAYEGRDRATGELKWLASRVDLVFGSHSQLRALSEVYGSEDSQQKFVRDFVAAWTKVMNADRFDIKHN
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase 2, CP 2, Peroxidase/catalase 2.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: HYPC_ECOLI
Sequence: MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDALQNMFDVEPDVGALLYGEEK
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Involved in the biosynthesis of the Fe(CN)(2)CO cofactor (PubMed:15504408, PubMed:23022438).  HypC delivers iron-bound CO(2) to HypD where reduction to CO probably occurs (PubMed:23851071).  In complex with HypD, accepts the cyanide ligand generated by HypF and HypE, and also coordinates the carbon monoxide ligand (PubMed:15504408, PubMed:23022438).  Involved in the maturation of the hydrogenase 3 (PubMed:10783387, PubMed:11292801).  Also participates in the maturation of hydrogenase 1 (PubMed:11292801).
What are the official names of this protein?
Hydrogenase maturation factor HypC, Chaperone-type protein HypC, Hydrogenase accessory chaperone HypC.
What is the protein family that this protein belongs to?
Belongs to the HupF/HypC family.
Protein: PROA_LACLA
Sequence: MIEELGLKVKKASKEVAKLSTADKNVFLQNLADSLIENTDRIISENEKDLANALEHGISEIMDDRLRLNAQRISDMATGLRQVAELPDPIRQVLQGFTNLDGLKILQKRVPLGTVGMIFESRPNVTIDAFSLCFKTGNSVLLRGGSDAIYSNMVLVEIIKENLLSAKITDGAVELLSDTSHAEAEKMMQADKFLDVLIPRGSARLINRVKEKATVPVIETGVGNCTIFVDESADLEMATKIVINAKTQRPSVCNAAESLVVHAKIADEFLPKLENEINKVHEIEFRADERALKVLSAGIPATDDDFGTEFLDYILSVKTVDNLDEAIEHINTYSSRHSESIVTHDYFNAQKFQDEIDAAAVYVNASTRFTDGFVFGLGAEIGISTQKLHARGPMGLEALTSTKYLIDGTGQIR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBI_BUXMI
Sequence: MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGREE
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein I, PSII-I, PSII 4.8 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the PsbI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MIAB_EHRRW
Sequence: MQGLYIKSYGCQMNVYDSLIIENIIKPLGFSIVNEPSEADIVILNTCHIREKAAEKLYSELGRIRKIQETKNLTIVVAGCVAQAEGTEIFTRAPFVDIVVGPQSIHTLPELIVKARKIKKQIINIDFPVISKFDAIAVEEYTKNQKVSAFISVQEGCNKFCSFCVVPYTRGEEYSRTVEAIFKEALILADSGIKEITLIGQNVNAYHGTYKGNEWDLGRLIQHIAKISSIERIYYTTSHPRDMHESLYEAHGIEKKLIPFIHLPVQSGSNKILRKMNRKHTAEEYINIIKTLRKHRSDIAYSSDFIVGFPGETDEDFENTIQLIEEVKFSQAYSFKYSPRPGTPSAEYTSQIPDEIKSQRLTKLQELVHKQQLEFNKKMIGETHPVLFYKKGKFDNQIIGKTPYMQSCYINTENPDLYYNKIVPIKITDAHKNHLTGIIPNTLPV
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_SYNPW
Sequence: MKGRFLVLEGIDGCGKTTQLRQLAEWLPDSGLMPEGATLHLTREPGGTPLGRALRELLLHPPDEAAPCPEAELLMYAADRAQHVQRRILPALACGDWVLSDRFSGSTLAYQGDGRGLDRALILDLERIATAGLVPDVTLWLDLSLEASMARREERTEDRIEAEGQAFLARVADGFRQLAAERGWVGIPAALSPKEVHQAIRLALEGHAALRRR
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RL6_NOCSJ
Sequence: MSRIGKLPVAVPSGVDVAIDGARVTVKGPKGTLSHTVAAPITVEKGDGVLDVKRPDDERESKALHGLTRTLVNNMVVGVTEGYEKKLEIVGVGYRVLSKGPTQLEFQLGYSHPITFNAPEGITFAVEGPTRLGVQGIDKQLVGEVAANIRKLRKPEPYKGKGVRYAGEHIRRKVGKAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: SYA_BORBU
Sequence: MTLNKLRKKYIDFFKSKKHFEIMGKSLVPENDPTVLFNTAGMQPLIPYLLGEVHPSGDMLVNVQKCLRTGDIDEVGDLSHLTFFEMLGNWSLGAYFKEYSVKCSFEFLTSSDYLNIPKDSLYVSVFEGDQEIPRDTETAKVWESLGISKDRIHYLSKDHNFWGPVGSKGPCGPDTEIYVDTGKSKCSLDCNITCSCGKYFEIWNNVFMQYNKDENGNYIELGRKCVDTGMGLERTIAFLQGKSSVYDTDAFMPIIKRIEYISGKIYGQKEDDDRCIRIISDHVKAACFILADSSVVFPSNLGQGYVLRRLIRRSIRYAKKLGIKSHFLADLVDSVEAIYRSFYNELTEKKDFIKKELSKEEEKFFKTLSQGEQEFIKITRNLPSKTIPGDIAFKLYDTYGFPYEVTEELAIEYGFNVDKLGFNEHFKKHQKTSKKGGDKVFKGGLADYTYETTKLHTATHLLHKALQLVLGDHVRQKGSNITAERLRFDFVHSEKMTDDEIKKVEEIVNLQIKNSLSVKKIIMELSEAREKGAMALFGEKYDDLVSVYEIDGFSLEVCGGPHVENTNELGTFKIQKEQSSSSGIRRIKAILIDE
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MODC_MANSM
Sequence: MMLEINVKKRLGQLVLNARLTIPGQGITGIFGISGSGKSSLINLVSGLIHPDEGNIRLNDRTLIDTANNICLAPNQRNIGYVFQDARLFPHYSVKGNLCYGIKRFNQQEFNRIVRLLGIEHLLARYPLTLSGGEKQRVAIGRALLSNPEMLLMDEPLSALDLPRKRELLAYLEKLSQEINIPILYVTHSLDELFRLADFVVLLDEGKVAAFDSLENLWQSPLFEPWQEQGQKSAVLSLPILNHNFSYKMTALLLGEQQLWVKLLNGDEGKTVRICIRSTDVSITLTVPEKTSIRNILSGKIITLLPKGNQVDVKIALGKDEIWASVSTWAAEELQLQIGQSVYAQIKAVSVM
What is the function of this protein?
Part of the ABC transporter complex ModABC involved in molybdenum import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Molybdenum import ATP-binding protein ModC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UPPP_ECO24
Sequence: MSDMHSLLIAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTAKTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGRPLQHEGESKGRLTLIHILLGMIPAVVLGLLFHDTIKSLFNPINVMYALVVGGLLLIAAECLKPKEPRAPGLDDMTYRQAFMIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATALDLYKSWGFLTTGDIPMFAVGFITAFVVALIAIKTFLQLIKRISFIPFAIYRFIVAAAVYVVFF
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MTNN_SHIFL
Sequence: MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
What is the function of this protein?
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively.  Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.  Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
What are the official names of this protein?
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, MTA/SAH nucleosidase, MTAN, 5'-deoxyadenosine nucleosidase, DOA nucleosidase, dAdo nucleosidase, 5'-methylthioadenosine nucleosidase, MTA nucleosidase, S-adenosylhomocysteine nucleosidase, AdoHcy nucleosidase, SAH nucleosidase, SRH nucleosidase.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
Protein: CZCR_BACCZ
Sequence: MELRDLQIFQSVADQGSVSSAAKELNYVQSNVTARIKQLENELKTPLFYRHKRGMTLTAEGRKMLVYVNKILQDVDELKQVFLDSETPSGILKIGTVETVSTLPTILSSYYKSYPNVDLSLQAGLTEELIREVLDHQLDGAFISGPIKHPLIEQYDVSTEKLMLVTQNKAFHIEEFTTTPLLVFNQGCGYRSKLERWLKDEGLLPKRIMEFNILETILNSVALGLGITLVPQSAVHHLSKAGKVHCHAIPEKYGSISTVFIRRKDSYMTNSMRSFLKTIEEHHHINML
What are the official names of this protein?
HTH-type transcriptional regulator CzcR.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: TTCA_SHEHH
Sequence: MSEELTPQQVTRMAKLQKRLRTEVGRAIGDYNMIEEGDRVMCCLSGGKDSYAMLDILLNLQQRAPIKFEIVAVNLDQKQPGFPEDILPAYLDTLGVAYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQKIGATKIALGHHRDDIIETMFLNMFFAGKMKAMPPKLLSDDGANMVIRPLAYSREKDIAEYAGLKGFPIIPCNLCGSQENLKRAAVKEMLVQWDRDYPGRIETIFTAMQNTAPSQGVDREQFDFLSLTRDPDAPMRGDVAESDLPAFDFVDVANNGHINLDKAVRIDVVNTYTPD
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_BURVG
Sequence: MTELFIDGAWVAGSGPVFASRNPGTDAIAWQGASASAADVERAVASARRAFAGWSALDFDARCEIVKRFAALLTERKEALAAAIGRETGKPLWEARTEVAAMAAKVAISIQAYHERTGEKRQDMADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAPGVARATVEVWHEAGLPAGVLNLVQGEKDTGIALANHRQIDGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVIGAVEDIDAAVHHTIQSAFLSAGQRCTCARRIFVPQGAHGERFLARLVDVTSKITADVFDADPQPFMGAVISARAAAKLVDAQARLIEQGARPIIEMTQRDARLGFVNASIIDVTDVARLPDEEHFGPLAQIVRYARFDEAIERANDTAFGLSAGLLSDDAHAWEQFRRTIRAGIVNWNRPTNGASSAAPFGGTGRSGNHRPSAYYAADYCAYPMASVESTQLSLPASLSPGLHF
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.