PharMolix/UniProtQA huggingface dataset:
Protein: UB10A_XENLA
Sequence: MASPSEQYIFGEFSDDEFKQFFVTARCTVELPPYNEHFFPCGPQSSGDFQDGEECPRIEFGIEEVIDHNTTLPNNTDYSISSNLNPQAPEFILTCSSSPKDSNNVLHENNFDAIDCQFSESSIPDGSGNADSDGTSGTGQRERKKKKKRPPGYYSYLEGVGDVPSETLLNGHANSAGLNSISTDDPDLAEDIPISTTSPRTCTSPDNFVDLNNEALSDDASMHNVLDNTRTAGQPEECSVTSSEQSCIPSDNGRESPVRTAVVQPFAGTDTTENLGVTNGQTLESPEEDTASNGVVLHPEVISLSEEAKAEEISTAQAVIHLPGSASANAPAKSWASLFHNSKPSSTPQVAYVETKNTPPVTSLQVTEKQVEIKEGPVPVSEDPVAIKIAELLEEVKLVHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKSIPVYTKAQKPCTSTPMIDSFVRLMNEFTNMPILPKAKQAPGEKVVRDIRPGAPFEPAYIYRLLTVFKSSLSEKGRQEDAEEYLGFILNGLHEEMLALKKLLLPQNDKIHINNGPDPVFATEEVNKEEQEGSDEEWEQVGPRNKSSVTRQADFVQTPITDIFGGHMRSVVYQQSSKESATLQPFFTLQLDIQSEKIRTVQDALESLVARESVQGYTTKTKQEVEICRRVTLEELPPVLVLHLKRFVFEKTGGCQKLIKNIEYPVDLEISKDLLSPGVKSKIFKGQRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKQTVERTAYLLYYRRVDLL
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/tp53.  Acts as an essential regulator of p53/tp53 stability: in unstressed cells, specifically deubiquitinates p53/tp53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/tp53.  Following DNA damage, translocates to the nucleus and deubiquitinates p53/tp53, leading to regulate the p53/TP53-dependent DNA damage response.  Component of a regulatory loop that controls autophagy and p53/tp53 levels (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 10-A, Deubiquitinating enzyme 10-A, Ubiquitin thioesterase 10-A, Ubiquitin-specific-processing protease 10-A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP10 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RUVA_POLNS
Sequence: MIGRIQGTLVSVHPPRLLVDCQGISYEVDVPMSTLYQLPQAGQKITLLTHFQVREDAQQLFGFATETEREAFRQLIKISGVGSRTALAVLSGMSVNELAQAIALQEAGRLTQVPGIGKRTAERLCLELKGKLAPDLGVAGGKPQAIETSSEVLQALLALGYSEKEALLALKQIPADTSISDGIRMGLKYLSKA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: AHPD_BRUME
Sequence: MSIDDLKSKIPDFAKDVRLNLSSMASDETLTPQQKYGLFVACGIASRNADVRKALVAEAAGKVDASVIQAAKAAASIMGMNNVYYRFVHLASNKDYRTMPARLRMNVISNPGVDKVDFELWSLAVSAINGCGMCIDAHEDVLRKANVTAEAIQAAVRFASIIQSAAIALEAADTE
What is the function of this protein?
Antioxidant protein with alkyl hydroperoxidase activity.  Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
What are the official names of this protein?
Alkyl hydroperoxide reductase AhpD, Alkylhydroperoxidase AhpD.
What is the protein family that this protein belongs to?
Belongs to the AhpD family.
Protein: DAPH_LACAC
Sequence: MTNLDAKSIIEYIGNAPKKTPVKVFIKGNLDQLNFPNTIENFTEQHSGIIFGDWKDVEPFLNDNKEKIVQYRIENDVRNSAVPLIDLKKFNARIEPGAIIRDQVAIGKNAVIMMGAIINIGAEIGDDTMIDMGVVLGGRAIVGKHCHIGAGSVLAGVIEPASAKPVQIDDDVVIGANAVVIEGIHVGKGAVIAAGAIVTKDVEPYTMVAGVPAKVIKKVDNKTLDKTGLEDDLRKI
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: CDS1_SOLTU
Sequence: MHNDSNSGAPGTPSGRIRRRRGSNEVPPEVVKANGNHLLVNDRSKYKSMLIRAYSSVWMIGGFAFIIYMGHLYIWAMVVVIQIFMAKELFNLLRRAHEDRHLPGFRLLNWHFFFTAMLFVYGRMLSQRLVNTVTLDKFLYKLVGRFVKYHMVTCYFFYIAGFMWFILTLKKKMYKYQFSQYAWTHMILIVVFTQSAFTVANIFEGIFWFLLPASLIVINDIAAYFFGFFFGRTPLIKLSPKKTWEGFIGASITTIISAFLLANMFGRFQWLTCPRKDLSTGWLDCDPGPLFKPEYFTLPEWFPAWFLSREIAVLPVQWHALLLGLFASIIAPFGGFFASGFKRAFKIKDFGDSIPGHGGMTDRMDCQMVMAVFAYIYHQSFIVPQNLSIEMILDQIILNLTFEEQLAVYKKLGQIIQERTFGES
What is the function of this protein?
May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction.
What are the official names of this protein?
Phosphatidate cytidylyltransferase 1, CDP-DAG synthase, CDP-DG synthase, CDP-diacylglycerol synthase, CDS, CDP-diglyceride pyrophosphorylase, CDP-diglyceride synthase, CTP:phosphatidate cytidylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CDS family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ECTC_RHOE4
Sequence: MIVRTTTEITDTDRDITSEDGNWRSKRIVLGGDRVGFSFHETTIKAGSVNEFHYANHVEAVWLVEGTGKLIDLDNNKEYDLAPGSMYLLNGHERHRVEPDTQMRMLCVFNPPVTGREVHDENGVYPLVEVPA
What is the function of this protein?
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
What are the official names of this protein?
L-ectoine synthase, N-acetyldiaminobutyrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the ectoine synthase family.
Protein: MG101_CANAL
Sequence: MFNLIRLGFPRTSIIRYYSSTAVNQAKVYSRTYKRAGPVTKSSTSTSRSTSTDASPASSSPPKESVSDIEPSSEVPVKSTTSYILHDAPLEASNKNNGETINWSDSFHGLGAQPFSKEIAEILLAPVAEEDIEIKPDGLLYLPEIKYRRVLNRAFGPGGWGLAPRTESLVTSGQISREYGLICHGRLVSIARGEQDYFGGEEKLTTALEGCKSNALMRCCKDLGIASELWDPSFIRRWKKKYCEEIFVEHVNTKKKKKIWKLKSIKTIDYPYKMT
What is the function of this protein?
Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome.  Binds to DNA (By similarity).
What are the official names of this protein?
Mitochondrial genome maintenance protein MGM101.
What is the protein family that this protein belongs to?
Belongs to the MGM101 family.
What are the subcellular locations of this protein?
Mitochondrion matrix, mitochondrion nucleoid.
Protein: RL331_STAAW
Sequence: MRVNVTLACTECGDRNYITTKNKRNNPERVEMKKFCSRENKQTLHRETK
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: NUOB_ECOLC
Sequence: MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLNDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIGKERRPLSWVVGDQGVYRANMQSERERKRGERIAVTNLRTPDEI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GRPE_HELAH
Sequence: MKDEHNQEHDLSQKELESCENSCTCEGKKQEASEKECEIKEDFELKYQEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSASGDDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAKND
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL31_BACVZ
Sequence: MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYTGRQKFASADGRVDRFNKKYGLK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: MOR1_BOMMO
Sequence: MNILKFFFVFIVAMSLVSCSTAAPAKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
What is the function of this protein?
Has antibacterial activity against Gram-positive and Gram-negative bacteria.  Probably acts by disturbing membrane functions with its amphipathic structure.
What are the official names of this protein?
Moricin-1.
What is the protein family that this protein belongs to?
Belongs to the moricin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAXI_RAT
Sequence: MDDLDALLADLESTTSHISKRPVFLSEEPPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVLDPLDQWQPSGSRYAHQQPPSPSPIYSSSTKNSSASNPQDSVGSLCSRAGEEEHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQRSPSGFSAGMVSVQASREPLGSWGTEGRAIILSPFFQDEAESSPPLPGALSPLYGVPESNNLLGGKAGPLMKEKPKRNGGRGLEDVRPSVESLLDELENSVPSPVPAITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQSCFLKLFC
What is the function of this protein?
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).  Recruits other proteins such as TRIM15 to focal adhesion.
What are the official names of this protein?
Paxillin.
What is the protein family that this protein belongs to?
Belongs to the paxillin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, cell cortex. Note=Colocalizes with integrins at the cell periphery. Colocalizes with PXN to membrane ruffles and the leading edge of migrating cells (By similarity).
Protein: Y1229_STRGC
Sequence: MYSISFQEESLLPRERLVRLGAEQLSNQELLSILIRTGNKKENVFQIASKILSSVSSLTELRHMTLSELQGMSGIGQVKAIELQAMIELGSRISKAENFEGERILSSQKLAKKMQQELSHKKQEHLVALYLNTQNQIIHQQTIFIGSLTRSLAEPREILHYAIKHMATSIILVHNHPSGATRPSRDDDQVTEKIKEACEMMGFVLLDHLIVGGDSYYSYREETDLI
What are the official names of this protein?
UPF0758 protein SGO_1229.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: ISAB_STAAN
Sequence: MNKTSKVCVAATLALGTLIGVTVVENSAPTSKQAQAAITPYYTYNGYIGNNANFILDKNFINAIKYDNVKFNGIKLAKTNTIKKVEKYDQTFKGVSAKGNEASQLQFVVKNNISLKDIQKAYGKDLKKENGKTKEADSGIFYYQNAKKTLGIWFVVDHNRVVEVTVGHTPYKTSK
What are the official names of this protein?
Immunodominant staphylococcal antigen B.
What is the protein family that this protein belongs to?
Belongs to the IsaB family.
What are the subcellular locations of this protein?
Secreted.
Protein: CYB_KOBME
Sequence: MTNMRKTHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYIFLETWNIGVILLFTTMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIAAIAMVHLLFLHETGSNNPTGISSDTDKIPFHPYYTIKDILGALLLILMLMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILVLMPLLHTSKQRSMMFRPISQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLLILVLMPTASTIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MNMA_BURO1
Sequence: MSKRRVVVGMSGGVDSSVTAWLLKEQGYDVVGLFMKNWEDDDDGEYCSTRQDWIDVVSVADLIGIDVEAVNFAAEYKDRVFAEFLREYSAGRTPNPDVLCNAEIKFKAFLDHAMSLDAEMIATGHYARVRERDGRFELLKAFDHTKDQSYFLHRLNQAQLSKTMFPLGEIPKTKVREIAAQIGLPNAKKKDSTGICFIGERPFRDFLNRYLPTKPGPMKTPDGKVVGEHIGLAFYTFGQRKGIGLGGSKSGSGEPWFVAAKDIASNTLYVVQGHDHPWLLSRELVAGNVSWVAGEPPADGFACGAKTRYRQADAACVFGGAATGAAAAGPAGEVRFSLAFDDAQWAVTPGQSAVLYDGEICLGGGIIESAATGQPGQATSAGHAPALAEAR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
Protein: GLIS1_HUMAN
Sequence: MAEARTSLSAHCRGPLATGLHPDLDLPGRSLATPAPSCYLLGSEPSSGLGLQPETHLPEGSLKRCCVLGLPPTSPASSSPCASSDVTSIIRSSQTSLVTCVNGLRSPPLTGDLGGPSKRARPGPASTDSHEGSLQLEACRKASFLKQEPADEFSELFGPHQQGLPPPYPLSQLPPGPSLGGLGLGLAGRVVAGRQACRWVDCCAAYEQQEELVRHIEKSHIDQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLHAGPDTEADVLTECLVLQQLHTSTQLAASDGKGGCGLGQELLPGVYPGSITPHNGLASGLLPPAHDVPSRHHPLDATTSSHHHLSPLPMAESTRDGLGPGLLSPIVSPLKGLGPPPLPPSSQSHSPGGQPFPTLPSKPSYPPFQSPPPPPLPSPQGYQGSFHSIQSCFPYGDCYRMAEPAAGGDGLVGETHGFNPLRPNGYHSLSTPLPATGYEALAEASCPTALPQQPSEDVVSSGPEDCGFFPNGAFDHCLGHIPSIYTDT
What is the function of this protein?
Acts as both a repressor and activator of transcription (PubMed:21654807).  Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).  By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807).  Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity).
What are the official names of this protein?
Zinc finger protein GLIS1, GLI-similar 1.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL23_STRP2
Sequence: MNLYDVIKKPVITESSMAQLEAGKYVFEVDTRAHKLLIKQAVEAAFEGVKVANVNTINVKPKAKRVGRYTGFTNKTKKAIITLTADSKAIELFAAEAE
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: YNCE_SALTY
Sequence: MHLRHLFSPRLRGSLLLGSLLVASSFSTLAAEDMLRKAVGKGAYEMAWSQQENALWLATSQSRKLDKGGVVYRLDPVTLEITQAIHNDLKPFGATINAATQTLWFGNTINSAVTAIDAKTGDVKGRLVLDARKRTEEVRPLQPRELVADAATNTIYISGVGKESAIWVVDGETIKLKTTIENTGKMSTGLALDSKAQRLYTTNADGEFITIDTASNKILSRKKLLDDGKEHFFINLSLDTAGHRAFITDSKATEVLVVDTRNGNILAKIAAPASLAVLFNPTRNEAYVTHRQAGQVSVIDAKTYNVVKTFDTPTYPNSLALSADGKTLYVSVKQKSTREQEATQPDDVIRIAL
What are the official names of this protein?
Uncharacterized protein YncE.
Protein: SECB_BURPS
Sequence: MSDVENQPFFNIQRIYLKDLSLEQPNSPAIFLEQEMPAVEVEVDVKAERLAENVYEIVVAGTVTAKVREKVAFLVEAKQAGIFDIRNIPAEQIDPLCGIACPTILFPYLRSNIADSITRAGFPPIHLAEINFQALYEQRLAEISQQQQQGGAPNGTTLN
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_CHLCH
Sequence: MEPLDALEKHGDIKKVLTEKLATLPTSPGIYQFKNSAGRIIYVGKAKNLRNRVRSYFRNSHQLFGKTLVLVSHIDDLEVIITSSEVEALILENNLIKELKPRYNVNLKDDKTYPYLVITNEPYPRILFTRHRRNDGSIAFGPYTEARQLRSILDLIGSIFPVRSCKLRLTPDAIASGKYKVCLDYHIHKCKGACEGLQPEDEYRQMIDEIIKLLKGKTSALIRSLTENMHLAATELRFEQAAEIKAQIESLKRYAERQKVVAADMVDRDVFAIAAGEDDACGVIFKIREGKLLGSQRIYINNTNGESEASMQLRMLEKFYVESIEPVPDEILLQEALSEEEEETLRAFLLVKAKNEGQEKKGIRLVVPQIGDKAHLVGMCRQNARHHLEEYLIQKQKRGEAAREHFGLTALKELLHLPTLPQRIECFDNSHFQGTDYVSSMVCFEKGKTKKSDYRKFKIKTFEGSDDYAAMDEVLRRRYSGSLTESLALPDLIVVDGGKGQVNTAYKTLQELGVTIPVIGLAKRIEEIFTPHSSDPFNLPKTSPALKLLQQLRDEAHRFAITYHRKLRSDRTLQTELTTIAGIGEKTAFKLLEHFGSVESVAQASREELQAVIGAKAGETVYTFYRPEG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_HAEIG
Sequence: MANYFNTLNLRQKLDQLGRCRFMDREEFADEANFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRPEAIAEKRASFQRATENGFKVGTYEELIPTADLVVNLTPDKQHSKVVADVMPLMKKDSAFGYSHGFNIVEVGEEIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGLAIAKAWAAATGGHKAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLVADGKDPAYAGKLIQYGWETITEALKQGGITLMMDRLSNSAKLRAFELAEQIKKSLGFLYYKHMDDIVSGHFSATMMADWENDDKDLFAWREATGKTAFENAPKYDGKISEQEYFDNGVLMIAMVKAGVELAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSNVATPILAKEIIPNLQKGDLGEPTPAVEVDNITLRAVNDAIRNHPVELIGQELRGYMTDMKRIAVAG
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 2, Ketol-acid reductoisomerase type II.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: KDKA_VIBCH
Sequence: MIQTFNDAQQKVWFDDALLHEDPSQCCNPEFWQQNGKVLGSATGRGTTWFVQLQQTQGALRHYRRGGLFGKLVADSYWFTGWEKTRSYQEFMLLNHLRDAGVNVPRPIAARVQKHGLLYKADLLSEKVPNARDLVSILQESPISDELYRKIGREIRKMHDAQVNHTDLNIHNILIDDQEKVWIIDFDKCYVQIGDSWKQGNLKRLKRSFEKEVCKRGINWSLEAFAIISSYKHEE
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
What are the official names of this protein?
3-deoxy-D-manno-octulosonic acid kinase, Kdo kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. KdkA/RfaP family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: URK_SALDC
Sequence: MTDQSHQCVIIGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPNAMDHSLLFQHLQALKRGSAIELPVYSYVEHTRMQETVRVEPKKVIILEGILLLTDARLREEMNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYC_MYCGE
Sequence: MIVDSVSQKPTTLVQKTINIYLCGPTVYNDLHLGNTRPLIVFDVLNRVLKKAKYTVNFVQNITDIDDKIIKIAQQQEVSESVVTKQQITAYKSLLKKLNILPIKHIQITEKIDKIPDYIDQLVNQNHAYVSTQNNVYFAVNSLKQYGYLANRMVHLEETDTDKKNKLDFVLWKITTAGIKWNSKWGLGRPGWHVECAFLIDYCFKNELTIHGGGVDLKFPHHENENALHMALYNQPITKHWMHIGHLMIENQKMSKSLQNFLLAVDFLNFHDFRVLRWIFYQKHYLHPIDLNQSLIEKANNDIQRIAKTLNVARTWLVYSEQSELISPKQYDPVFSALLDNLNFANAVAAIWKLIKKINTSIKTKDFSVLREQLSFLEWSIDLLGISFKSIHTKLNVRLIKEWSILHKQKAMDKADQIRKKLIKKMLL
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPB_BORPE
Sequence: MIKWLARPADYASVWDAMKTFTAARGPGTADEIWLCEHAPVYTLGQVGRPEHLLNPGLIPVVHCDRGGQVTYHGPGQVLAYTLFDLRRAGLYVREYVDMLEQATLATLRELGLEQACRKPGAPGIYVPQPGGELAKIAALGVKVRNGYAYHGLALNIDMDLSPFLGINPCGYEGLRTVDLAACGVRTSVERAGELLAAQLARAHGQAVQQRAAALAGVPG
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MACOI_RAT
Sequence: MKRRNADCSKLRRPLKRNRITEGIYGSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRSVYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLWILFVYIEAAIRFKDLKNFHVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFYMQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILIHHNGGIPANKKLSTALPEIEYREKGKEKDKDAKKHNLGINNNNILQPVDSKIQEIEYMENHINSKRLNNDLVGSTENLLKEDSCTASSKNYKNASGVVNSSPRSHSATNGSIPSSSSKNEKKQRCTSKGPSAHKDLMENCIPNNQLSKPDALVRLEQDIKKLKADLQASRQVEQELRSQISSLSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKRLKAEQEARGFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTMDLKVKEEQIRELELKVQELRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSITYSAATSPLSPVSPHYSSKFVETSPSGLDPNASVYQPLKK
What is the function of this protein?
Plays a role in the regulation of neuronal activity.
What are the official names of this protein?
Macoilin, Macoilin-1, Transmembrane protein 57.
What is the protein family that this protein belongs to?
Belongs to the macoilin family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi- pass membrane protein. Note=Detected in the nucleus membrane of non-neuronal cells and in axonal outgrowths of neuronal cells.
Protein: TRHO_THIDA
Sequence: MSIVNISCYKFVTLNDREALKADLGARCLQLGLRGTILLAPEGINVFLAGTRAAIDAIVAGLRADPRFADLEPKLSLSAEAPFTRMRVRLKKEIITMKMPVVRPEEGRAPAVAAATLKRWLDQGCDDEGRPVVMLDTRNDYEVAAGSFENAVDYGIGVFSEFPPQLQRRRDDYAGKTVVSFCTGGIRCEKAAIHMQEIGVERVYQLEGGILKYFEEVGGAHYRGGCFVFDAREAVGADLQPLGGRVHC
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.