PharMolix/UniProtQA huggingface dataset:
Protein: POLS_JAEVM
Sequence: MTKKPGGPGKNRAINMLKRGLPRVFPLVGVKRVVMSLLDGRGPVRFVLALITFFKFTALAPTKALLGRWRAVEKSVAMKHLTSFKRELGTLIDAVNKRGKKQNKRGGNESSIMWLASLAIVIACAGAMKLSNFQGKLLMTINNTDIADVIVIPTSKGENRCWVRAIDVGYMCEDTITYECPKLAVGNDPEDVDCWCDNQEVYVQYGRCTRTRHSKRSRRSVSVQTHGESSLVNKKEAWLDSTKATRYLMKTENWIIRNPGYAFLAAALGWMLGSNSGQRVVFTILLLLVAPAYSFNCLGMGNRDFIEGASGATWVDLVLEGDSCLTIMANDKPTLDVRMINIEASQLAEVRSYCYHASVTDISTVARCPTTGEAHNEKRADSSYVCKQGFTDRGWGNGCGLFGKGSIDTCAKFSCTSKAIGRTIQPENIKYEVGVFVHGTTTSENHGNYSAQVGASQAAKFTVTPNAPSITLKLGDYGEVTLDCEPRSGLNTEAFYVMTVGSKSFLVHREWFHDLSLPWTSPSSTAWRNRELLMEFEEAHATKQSVVALGSQEGGLHQALAGAIVVEYSSSVKLTSGHLKCRLKMDKLALKGTTYGMCTEKFSFAKNPADTGHGTVVIELTYSGSDGPCKIPIVSVASLNDMTPVGRLVTVNPFVATSSSNSKVLVEMEPPFGDSYIVVGRGDKQINHHWYKAGSTLGKAFSTTLKGAQRLAALGDTAWDFGSIGGVFNSIGKAVHQVFGGAFRTLFGGMSWITQGLMGALLLWMGVNARDRSIALAFLATGGVLVFLATNVHADTGCAIDITRKEMRCGSGIFVHNDVEAWVDRYKYLPETPRSLAKIVHKAHQEGVCGVRSVTRLEHQMWESVRDELNVLLKENAVDLSVVVNKPVGRYRSAPKRLSMTQEKFEMGWKAWGKSILFAPELANSTFVVDGPETKECPDERRAWNSMQIEDFGFGITSTRVWLKIREENTDECDGAIIGTAVKGHVAVHSDLSYWIESRLNDTWKLERAVFGEVKSCTWPETHTLWGDGVEESELIIPHTIAGPRSKHNRREGYKTQNQGPWDENGIVLDFDYCPGTKVTITEDCGKRGPSIRTTTDSGKLITDWCCRSCSLPPLRFRTENGCWYGMEIRPVRHDETTLVRSQVDAFNGEMIDPFSAGPSGDVSGHPGGPSQEVDGQIDDSCGFGGPTCADAWGHHLH
What is the function of this protein?
Binds to host cell surface receptor and mediates fusion between viral and cellular membranes.  Envelope protein is synthesized in the endoplasmic reticulum in the form of heterodimer with protein prM.  They play a role in virion budding in the ER, and the newly formed immature particle is covered with 60 spikes composed of heterodimer between precursor prM and envelope protein E.  The virion is transported to the Golgi apparatus where the low pH causes dissociation of PrM-E heterodimers and formation of E homodimers.  prM-E cleavage is inefficient, and many virions are only partially matured.  These uncleaved prM would play a role in immune evasion.
What are the official names of this protein?
Structural polyprotein.
What are the subcellular locations of this protein?
[Peptide pr]: Secreted. SUBCELLULAR LOCATION: [Small envelope protein M]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Note=ER membrane retention is mediated by the transmembrane domains. SUBCELLULAR LOCATION: [Envelope protein E]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Note=ER membrane retention is mediated by the transmembrane domains. SUBCELLULAR LOCATION: [Non-structural protein 1']: Secreted. Host endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=Located in RE-derived vesicles hosting the replication complex.
Protein: ARGB_RUTMC
Sequence: MLNNMSNNTNNITSVLTESLPYIKKFQGKTIVIKYGGNAMVDEALKSSFARDIVLMKLVGMNPIVVHGGGPQIGKTLKKIGKQSQFIDGMRVTDSETMDVVEMVLGGLVNKEIVNLIHQHGGHSIGLTGKDGSLISAKKLKHDIEPTSEIIDLGHVGEVDKIDISVINLLLKGDFIPVIAPIGVGKDGFSYNINADLVASAIAQALNAEKLILLTNASGLLDANGELLTRLDDNIIDGLIKDGTIHSGMLPKINCALSAVKNGVKSTHIIDGRVAHAVLLEVFTNSGVGTLITCNE
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NMT2_HUMAN
Sequence: MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ
What is the function of this protein?
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952).  Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017).  Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).
What are the official names of this protein?
Glycylpeptide N-tetradecanoyltransferase 2, Myristoyl-CoA:protein N-myristoyltransferase 2, NMT 2, Peptide N-myristoyltransferase 2, Protein-lysine myristoyltransferase NMT2, Type II N-myristoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NMT family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: VP35_EBORE
Sequence: MYNDKLKICSGPETTGWISEQLMTGKIPVTDIFIDIDNKPDQMEVRLKPSSRSSTRTCTSSSQTEVNYVPLLKKVEDTLTMLVSATSRQNAAIEALENRLSTLESSLKPIQDMGKVISSLNRSCAEMVAKYDLLVMTTGRATSTAAAVDAYWKEHKQPPPGPALYEENALKGKIDDPNSYVPDAVQEAYKNLDSTSTLTEENFGKPYISAKDLKEIMYDHLPGFGTAFHQLVQVICKIGKDNNLLDTIHAEFQASLADGDSPQCALIQITKRVPIFQDVPPPTIHIRSRGDIPRACQKSLRPAPPSPKIDRGWVCLFKMQDGKTLGLKI
What is the function of this protein?
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.  Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes (By similarity).  Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes (By similarity).  Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1.  VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between genome replication and genome packaging into the nucleocapsid.  Prevents establishment of cellular antiviral state, thereby suppressing host DC maturation.  Acts by inhibiting host RIGI activation both by shielding dsRNA from detection and by preventing PRKRA binding to RIGI.  Blocks virus-induced phosphorylation and activation of interferon regulatory factor 3/IRF3, a transcription factor critical for the induction of interferons alpha and beta.  This blockage is produced through the interaction with and inhibition of host IKBKE and TBK1, producing a strong inhibition of the phosphorylation and activation of IRF3.  Also inhibits the antiviral effect mediated by the host interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.  Increases PIAS1-mediated SUMOylation of IRF7, thereby repressing interferon transcription (By similarity).  Also acts as a suppressor of RNA silencing by interacting with host DICER1, TARBP2/TRBP and PRKRA/PACT (By similarity).  As a dimer, binds and sequesters dsRNA contributing to the inhibition of interferon production (By similarity).
What are the official names of this protein?
Polymerase cofactor VP35.
What is the protein family that this protein belongs to?
Belongs to the filoviridae polymerase cofactor VP35 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: NAA25_HUMAN
Sequence: MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWSPPAEGEHSLEGEVHYSAEKAVKFIEDRITEESKSSRHLRGPHLAKLELIRRLRSQGCNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQQHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGLEFGKTCLKTELQFSDYYCLLAVHALIDVWRETGDETTVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEDLRDNRDLNVFFSWDPKDRDVSEEHKKLSLEEETLWLRIRSLTLRLISGLPSLNHPVEPKNSEKTAENGVSSRIDILRLLLQQLEATLETGKRFIEKDIQYPFLGPVPTRMGGFFNSGCSQCQISSFYLVNDIYELDTSGLEDTMEIQERIENSFKSLLDQLKDVFSKCKGDLLEVKDGNLKTHPTLLENLVFFVETISVILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTLISNVVDHIKGLETHLIALKLEELILEDTSLSPEERKFSKTVQGKVQSSYLHSLLEMGELLKKRLETTKKLKI
What is the function of this protein?
Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln.  May play a role in normal cell-cycle progression.
What are the official names of this protein?
N-alpha-acetyltransferase 25, NatB auxiliary subunit, Mitochondrial distribution and morphology protein 20, N-terminal acetyltransferase B complex subunit MDM20, NatB complex subunit MDM20, N-terminal acetyltransferase B complex subunit NAA25, p120.
What is the protein family that this protein belongs to?
Belongs to the MDM20/NAA25 family.
Protein: NUOI1_SYMTH
Sequence: MNGVAAIAKGMATTLKVLFRKPVTVDYPYVKRPRAPRFRGRHELRTYENGLEMCVGCELCQVACPAAAITVQAAENDPDNPHSPGERYGYKYQVDLLRCIFCGMCEEACPTDCLHLTQEFELADFTRESLILQKEQLVNRNPSGFKVPMNVYPPFRRKAVNA
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I 1, NADH dehydrogenase I subunit I 1, NDH-1 subunit I 1.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GLMM_SYNR3
Sequence: MADLASHPVGQPLGGGGVSFGTDGIRGRVGTVMTPALALQVGYWSGQVLPGDAPVLLGMDSRSSGPMLVAALEAGLTAAGREVWTLGLCPTPAVARLVNQFQAAGGLMVSASHNPPEDNGIKLFGPSGAKLSRDQQQAIEAGLRGEVRPALTSCGPTQRRTELLESYTALLENSLEGRRLDGRRIVLDLCWGSATSCAESLFRRLGAEVIALHSQPDGAAINVGCGSTHLEPLRQAVMEHGAEMGFAFDGDADRVLAVDGQGRLVDGDHILYLWGSALADADALPQQRLVATVMSNLGFERAWTARGGQLERTAVGDQHVHAAMAELGAVLGGEQSGHIISADHGMSGDGVLTALQLAALLQPGETLSDRVDQSFRSFPQRLRNVRVPDRDRRKGWQQCDGLTTAIAAAEAAMGDEGRVLVRASGTEPLLRVMVEASSQEQVDHWTDHLSELADQLLNV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: YGCU_ECO57
Sequence: MSLSRAAIVDQLKEIVGADRVITDETVLKKNSIDRFRKFPDIHGIYTLPIPAAVVKLGSTEQVSRVLNFMNAHKINGVPRTGASATEGGLETVVENSVVLDGSAMNQIINIDIENMQATAQCGVPLEVLENALREKGYTTGHSPQSKPLAQMGGLVATRSIGQFSTLYGAIEDMVVGLEAVLADGTVTRIKNVPRRAAGPDIRHIIIGNEGALCYITEVTVKIFKFTPENNLFYGYILEDMKTGFNILREIMVEGYRPSIARLYDAEDGTQHFTHFADGKCVLIFMAEGNPRIAKATGEGIAEIVARYPQCQRVDSKLIETWFNNLNWGPDKVAAERVQILKTGNMGFTTEVSGCWSCIHEIYESVINRIRTEFPHADDITMLGGHSSHSYQNGTNMYFVYDYNVVNCKPEEEIDKYHNPLNKIICEETIRLGGSMVHHHGIGKHRVHWSKLEHGSAWALLEGLKKQFDPNGIMNTGTIYPIEK
What are the official names of this protein?
Uncharacterized FAD-linked oxidoreductase YgcU.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
Protein: GSH1_SALHS
Sequence: MIPDVSQALAWLEKHPQALKGIQRGLERETLRVNADGTLATTGHPEALGSALTHKWITTDFAEALLEFITPVDGDIQHMLTFMRDLHRYTARKLGDERMWPLSMPCYIAEGQDIELAQYGTSNTGRFKTLYREGLKNRYGALMQTISGVHYNFSLPMAFWQAKCGVTEGEAAKEKISAGYFRLIRNYYRFGWVIPYLFGASPAICSSFLQGKPTTLPFEKTDCGMYYLPYATSLRLSDLGYTNKSQSNLGITFNDLHEYVAGLKRAIKTPSEEYARIGVEKDGKRLQINSNVLQIENELYAPIRPKRVTRSGESPSDALLRGGIEYIEVRSLDINPFSPIGVDEQQVRFLDLFMVWCVLADAPEMSSDELLCTRTNWNRVILEGRKPGLTLGIGCETAQFPLPKVGKDLFRDLKRVAQTLDSIHGGEEYQKVCDELVACFDNPELTFSARILRSMIDEGIGGTGKAFGEAYRNLLREEPLEILQEEEFIAERDASVRRQQEIEAADTEPFAAWLAKHA
What are the official names of this protein?
Glutamate--cysteine ligase, Gamma-ECS, GCS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
Protein: EFTU_ACHLI
Sequence: MAKQKFERTKPHVNVGTIGHVDHGKTTLTAAITSVLAGKGLATKRDYNQIDGAPEEKARGITINASHVEYETVNRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPKLVVFLNKADLVDDEELLDLVEMEVRELLSEYDFPGDDIPVIKGSALGALEGKPEWVAKVEELMDAVDAYIDTPLRATDKPFMMPVEDVFTITGRGTVATGRVDRGIVKVGDQVEIVGITDTKTTTVTGVEMFRKLLDQAEAGDNIGALLRGVDREGVERGQVLSKPGTVKPHAKFTAQIYVLSKEEGGRHTAFFSNYRPQFYFRTTDITGIITLGEGTEMVMPGDNAEVTVELIHPIALEEGTKFSIREGGRTVASGSVVKILAD
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAN_METB6
Sequence: MGDILRDTADPQTPEELCRLYRSLTEQLRDQLQRIETDKQDLESQMLERISSLESRNLELREQIRQAEADKRYIETQKIRYEREVRKLKSESEQLRSPPLIIGTVVDVVDANRVIVRSSAGPRFLVRSSPSVNPDDIKPGARCTLNQQSLAIVELLPSSFDAQVYGMELVDSPQECYTDIGGLKEQINEVREAVELPLKRPELFTQIGIEPPKGVLLYGPPGTGKTLLAKAVAHETNAHFMRVVGSELVQKYIGEGARLVRELFDLAKKKAPTIIFIDEIDAVGASRTEANTSGDREVQRTLMQLLAGMDGFETRGDVKIIGATNRIDILDKALLRPGRFDRIIEIPLPDEEGRLSILKVHTRTLTMEETVNLPEIAGLTEGKNGADLRAICMEAGMYAIRNERPAITREDFLSAIEKVRLDFSHSPTDSEGRMFA
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle.  Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.  Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
What are the official names of this protein?
Proteasome-activating nucleotidase, PAN, Proteasomal ATPase, Proteasome regulatory ATPase, Proteasome regulatory particle.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_MYCMS
Sequence: MKKKIVAIIGRPNVGKSSLFNRIIKEKKSIVDNKPGVTRDRIYSNAEWLTREFILVDTGGISIDQQLFSNEIQIQTQIAIEQADVIIFVVDFLNRLDKDDKMIAKILHKSKKPVILAINKYDKKTIDDHNYEFMNLGFSDLYFISSTHGIGIGDLLDKVISYISKNDVDLKDDSTKIAIIGRPNVGKSSLVNSLVNENRMIVSEIEGTTLDAVDISFSYNKNKYTVIDTAGIRKKSKLGQTVEKYSYLRSLSAITNSDIVLLMIDATKPITDQDTNIGGLIYDEKKPVIIVVNKWDLVKNKQEQILKKEEEIRAYFKYISYAKIIFISALDKTRVTKILDLVADIKQSLSVKVKTYVLNEVLNKAQLINPAPEFNGNRLKIYYASQVQAYIPTFVLFCNHPNYLHFSYKRFLENQIRFSFGFDSIPINLIFRERK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: RPOB_PROM4
Sequence: MSRSAIQVAKTATHLPDLVEVQRASFKWFLEKGLIEELENFSPITDYTGKLELHFIGSEYRLKRPRHDVEEAKKRDATFASQMYVTCRLINKETGEIKEQEVFIGELPLMTERGTFIINGAERVIVNQIVRSPGVYFKDEQDKNGRRTYNASVIPNRGAWLKFETDKNDLLHVRVDKTRKINAHVLMRAMGLSDNDVIDKLRHPEYYKKSIEAADEEGISSEDQALLELYKKLRPGEPPSVSGGQQLLQSRFFDPKRYDLGRVGRYKINKKLRLTIPDSVRTLTHEDVLSTIDYLINLELDVGGATLDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIKERMTVGETDSLTPAQLVNPKPLVAAVKEFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLTRERAGFAVRDIHPSHYGRLCPIETPEGPNAGLINSLATHARVNDYGFIETPFWKVDKGRVIKEGKPIYLSADLEDECRVAPGDVATDKEGMIVADLIPVRYRQDFEKVPPEQVDYVQLSPVQVISVATSLIPFLEHDDANRALMGSNMQRQAVPLLRPERPLVGTGLETQVARDSGMVPISQVNGTVTYVDANIIVVTDEEGSEHHHSLQKYQRSNQDTCLNQRPIVHNGDPVIIGQVLADGSACEGGEIALGQNVLIAYMPWEGYNYEDAILVSERLVKDDLYTSVHIEKYEIEARQTKLGPEEITREIPNIAEESLGNLDEMGIIRIGAFVESGDILVGKVTPKGESDQPPEEKLLRAIFGEKARDVRDNSLRVPSTERGRVVDVRIYTREQGDELPPGANMVVRVYVAQRRKIQVGDKMAGRHGNKGIISRILPREDMPYLPDGTPVDIVLNPLGVPSRMNVGQVFELLMGWAASNLDCRVKVVPFDEMYGAEKSYQTVTAYLKEAASLPGKEWVYNPEDPGKLLLRDGRTGEPFDQPVAVGYSHFLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQQGGQRLGEMEVWALEAYGAAYTLQELLTVKSDDMQGRNEALNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIGVYTDEGKEVDLMQDVNPRRSTPSRPTYESLGSDYQED
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: LHPL7_MOUSE
Sequence: MEVGVRAALGLSLTGMSGLSLISPAWFQSLSSSYGIFTYCSWPPGDCWNQSCVTFGSLKDMPSLAWKVSAATLLGGWLLLSISALLLSAWALAPRRLFARTGFGPTPVVQAAAAVSMLVGLLVFPATLASPFAKEICEGSSMYHSGACRLSWGYATAILNMVLTSLLVIRWQVTTVQRAAVPFSSETQRAILVPE
What are the official names of this protein?
LHFPL tetraspan subfamily member 7 protein, Transmembrane protein 211.
What is the protein family that this protein belongs to?
Belongs to the TMEM211 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YRVC_BACSU
Sequence: MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDENDHEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQTIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKLTAKGA
What are the official names of this protein?
Uncharacterized protein YrvC.
Protein: NADK_PICTO
Sequence: MKVAIVTKINCKSCINIARIIISALPSDWDIIYEKSLARAIKKPGLEINEINADIIIVIGGDGTILRTAQFAHGNILGINVGGLGFLSEIEIGNIEASILKLIRNEYTIIEYMGLDVYVNGVYSGKAINDAVIHTDKVSKIRKFRLYENNYFIETTSADGVIVATPIGSTSYSFSAGGPILMPNLNGIVVSYIAPVGFRSRSIVFSEKTDLKIAIVGERSLLTIDGQIEKKLSKNDVVNIRVSENGARFISMYTNFYEKLREKLIKDVVN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURI_LEPBL
Sequence: MKGPLKIGLMDSGMGGLSVLKGILKYDAELEVVYYGDLKNSPYGEKETSEILELVRDVCKRLQEENVSAILLACNTATSAAAQTLRKEFSIPIFGMEPAIKPAILQNPGKKIALLATPVTQREKKLQRLKAELGAEELILPVSCPGLAGLVDKGEFDEAEKYLRPILKKLREENVENLVLGCTHYIFLKHIILKNFPNVRIYDGNSGTIKHLLNSLQVRQRVSNRSSVSGSVYKLILNSDEELHFRLATELLQFENKF
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: RSGA_VIBCH
Sequence: MTKKKKLTHGQVRRVRNNQHKKLKQEESIVWDEALLGSAQPGLVITRFGQHADIEDPVTGEIHRCNLRRGIESLVSGDNVLWRPGAETLAGISGVVEAVEARSSVLVRPDYYDGLKPVAANVDQMVIVSSVLPELSLNIIDRYLIASETLGIAPLIVLNKIDLLSPELREQYSTWLNDYRAIGYDVLYVSKKTGEGIADLEVKLRDRTNVFVGQSGVGKSSLVNALLPELEEDVEEGAISETSGLGQHTTTAARLYHIPSGGDLIDSPGVREFGLWHLETDDVTKAYVEFRPYLGGCKFRDCKHGDDPGCLLREAVSKGEISALRFDNYHRIVQSMTENKANRQYSRSKKPICKSKLLASLEHLLTEGAIFSNISRPSPLYWNVNHG
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Helps release RbfA from mature subunits.  May play a role in the assembly of ribosomal proteins into the subunit.  Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.
What are the official names of this protein?
Small ribosomal subunit biogenesis GTPase RsgA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEA_AMOA5
Sequence: MKLSSFKFTLPSKLIASHPVENREDARLMVVHKRTGQIEHKTFKDLIDYLGENDTLVLNDAKIFPSKLYGSKEKTGAQIEVFLLRELESGEHLWDTLVEPARKIRVGNKLYFGDGELVAEVLDNTTSRGRTLKFLFEGTREEFYEIVDQLGFVPLPNQLKRKPETEDRERYQTVYAQHIGAVVPPFAGLHFSAHLLKRLELKGVHITPLTLHIGLNSMKIIDVEDLTKYRIGSEQFLIPDNTVTTVNTALDDKKQVCAVGTSTIKALETSVSVAGRLKPAQGWTNKLIFPPYDFKVCTSLITNFHLPESLPLVNAAAFGGYELMMEAYQIAIKEKYRFFVYGDAMLII
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LRC8E_XENLA
Sequence: MIPVAEFKQFTEQQPAFKVLKPWWDVLAEYITYAMLMIGVFGCTLQVTQDKIICLPNHTSADVVSQITCQEFTQQSSASNDSDLETTVPPPTATSSPPREMSGLRNNLDLQQYSFINQMCYETALHWYAKYFPYLVVIHTLIFIICGNFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGESSQEKPNQERSIDRELSKPNFEEGSPATADLPIPDKLVAETSSASALDKKEGEQAKALFEKVKKFRHHVEEGDLLYSMYMRQTVLKVCKFVLITIYNAVLVGKIHFIVPCSVHTEDMTGYNSFCCNHTKAHLFSKLAISYLCFLGVYGLTCFYTLYWLFRRPLKEYSFRSVREETGIGDIPDVKNDFAFVLHLVDQYDSLYSKRFAVFLSEVSESRLRQLNLNHEWPADKLRQKLQHTPEGRLELHLFKLPGLPDTVFEVAEMESLKLEMVNEALIPPLVSKLVRLEELSLLNCTAKVQHASMAYLRDHLRILQVKFDDIKEIPLWIFGLRALEELHLFGWLSQDLSKNPALESLRELKSLKVLTIKSNLSKIPATVADVAGHLQKFSIHNDGTKLLTLNALKRLVLVKELELVRCELERIPHAVFSLTNLQVLDLKENTLHTIEEIISLQHCRKLSVLRLWHNQIAYIPDHIRKLKGLEELSLNRNKILVIPSQLFLCNKLRHLDLSFNEIRELPPEIGVLQLLQYLGLSGNFLEDLPTELFFCQKLKTLKLGQNRLASLSPKVGSLVCLVKLELKGNRMDMLPPEIGNCLSLKRSGLNVESLLFDTLPVDVRDKFKED
What is the function of this protein?
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes.  The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine.  Mediates efflux of amino acids, such as aspartate, in response to osmotic stress.  The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol.  Channel activity requires lrrc8a plus at least one other family member (lrrc8b, lrrc8c, lrrc8d or lrrc8e); channel characteristics depend on the precise subunit composition.  Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles, which store and then expel excess water to maintain cytosolic water homeostasis.
What are the official names of this protein?
Volume-regulated anion channel subunit LRRC8E, Leucine-rich repeat-containing protein 8E.
What is the protein family that this protein belongs to?
Belongs to the LRRC8 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Lysosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=In the absence of lrrc8a, resides primarily in the endoplasmic reticulum. Requires lrrc8a for localization at the cell membrane or lysosome membrane.
Protein: RL24_STAAN
Sequence: MHIKKGDNVKVIAGKDKGKEGKVIATLPKKDRVVVEGVNIMKKHQKPTQLNPEGGILETEAAIHVSNVQLLDPKTNEPTRVGYKFVDGKKVRIAKKSGEEIKSNN
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.