PharMolix/UniProtQA huggingface dataset:
Protein: VE7_HPV48
Sequence: MRGDKATIPDIELEELVLPANLISDESLSPDATAEEEFCPYRIDSKCHNCGCRIRVTVAATEFGIRCFEQLLLKELCLFCPACSRQLPRNGRS
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: RUVB_STRPB
Sequence: MARILDNDVMGNEEFSDRTLRPQYLREYIGQDKVKEQFAIFIEAAKRRDESLDHVLLFGPPGLGKTTMAFVIANELGVNLKQTSGPAVEKAGDLVAILNELEPGDILFIDEIHRMPMSVEEVLYSAMEDFYIDIMIGAGDTSRSIHLDLPPFTLIGATTRAGMLSNPLRARFGITGHMEYYQEKDLTEIVERTATIFEIKIDHEAARKLACRSRGTPRIANRLLKRVRDYAQIIGDGIITAQITDRALTMLDVDREGLDYIDQKILRTMIEMYQGGPVGLGTLSVNIAEERNTVEEMYEPYLIQKGFLMRTRTGRVATQKAYRHLGYPYQNT
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: VMO1_MOUSE
Sequence: MELQAGARLLLLLGVMCYGHAQIQVHVEPRYASIVDVTNGGTWGDWAWPEMCPDGYFASGFSVKVEPPQGIPGDDTALNGIRLHCTRGNSQKNTHVVESQSGSWGSWSEPLWCPGTSFLVAFCLRVEPFTFPGDNTGVNNVRFRCSDGVELEGPGLNWGDYGEWSNSCPKGVCGLQTKIQKPRGLRDDTALNDIRIFCCAS
What are the official names of this protein?
Vitelline membrane outer layer protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the VMO1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LHDAG_HDVU2
Sequence: MSRSESKKNRGGREEILEQWVGARKKLEELERDLRKIKKKIKKLEEENPWLGNIKGILGKKDREGEGAPPAKRARADQMEVDSGPRKRPFRGEFTDKERRDHRRRKALENKRKQLSSGGKSLSKEEEEELRKLTEEDERRERRVAGPRVGGVNPLEGGTRGAPGGGFVPSMQGVPESPFARTGEGLDVRGNQGFPWDILFPADPPFSPQSCRPQ
What is the function of this protein?
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal.  Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding.  Packages the HDV ribonucleoprotein in hepatitis B virus empty particles.  Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg.  May inhibit viral RNA replication (By similarity).
What are the official names of this protein?
Large delta antigen, L-HDAg, p27.
What is the protein family that this protein belongs to?
Belongs to the hepatitis delta antigen family.
What are the subcellular locations of this protein?
Virion. Host nucleus, host nucleolus. Note=isoprenylated in the cytoplasm, and translocates in the nucleus possibly after phosphorylation. Translocates after to nuclear speckle, then to the ER membrane where interaction with Hepatitis B virus antigene takes place (By similarity).
Protein: EX7S_THEP3
Sequence: MNEELTFEEEMMRLEEIVNTLEKGNLRLEESFNLFKEGVEISKRLEKRLSEVEGKITLLINENEEIDFKEEEKDV
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP166_BPPH5
Sequence: MKLLTHTCHYCSFSFFTRKFDVFGAITKKDTPVVFCPACGNQSLSVSHIEEEII
What are the official names of this protein?
Gene product 16.6, gp16.6, Protein p16.6.
What is the protein family that this protein belongs to?
Belongs to the phi29likevirus gp16.6 family.
Protein: RL18_ACTP2
Sequence: MDKKVARIRRATRARHLMREQGATRLVVHRTPRHIYAQVIAPNGSEVLAAASTVEKVIKEQVKYTGNKDAAAVVGKLVAERALAKGIQAVAFDRSGFKYHGRVQVLADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: URE2_FRACC
Sequence: MIPGEILTGDDPVEINAGRPVRTVLVRNMGDRPVQVGSHYHFAAANPALDFDRASAWGHRLAVPAGTAVRFEPGVEREIELVPLAGARVVPGLRPESAGPLDAASGTRIADTATIEDISGFQGEGS
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NR1BB_DANRE
Sequence: MFGGWRLVVWQIFSEIITRRLGFWICLYFAALSVGMISGSEPLVRTRHIQNTHTVPINRSPGSLRAWQAGSTYVFGRQGGVITYSWPPHDRPSTRVDRLALGFSTLMEDATLVRVDSSAGLGDYLKLHIVKGNVVAVFNVGTYDINIEEKAKLVNDGNYHIVRFTRSGGNATLQVDDLPVIERFPPGHIDSHRLGTGRLPYRRLVEESLPKNGRQLTIFNSQMTIRIGGWQKQQVSGFQGQMSGFYYNGLKVFSMAADGDPNVRMEGSVRLVGELQSSSTPHGGATVYQSSVTEISSTTSNTITITYSTPADEQQTTDELLVASAECPSDDEDIDPCEPSSGTLCCFVPPAGPTGPAISSFPGPAEVFRESNGTTGMVVGIVAGAALCILILLYAMYKYRNRDEGSYHVDESRNYICNSNGAALKEKNTADDDSGSKSKKNKNKEYYV
What is the function of this protein?
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.  May play a role in formation or maintenance of synaptic junctions.
What are the official names of this protein?
Neurexin-1b-beta, Neurexin Ib-beta.
What is the protein family that this protein belongs to?
Belongs to the neurexin family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: MNME_STUS1
Sequence: MIPARDTIAAVATAPGRGGVGIVRVSGPRARAIAITLSGREPTPRHAHYGPFHADDGEVIDEGLLLFFPGPHSFTGEDVLELHGHGGPVVLDMLLQRCVDLGVRLARPGEFSERAFLNDKLDLAQAEAIADLIEASSAQAARNAVRSLQGEFSRRVHQLTERLIQLRIYVEAAIDFPEEEIDFLADGHVLAQLDGVRTELSTVLREAGQGALLRDGMTVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHILIDGMPLHVVDTAGLRDTEDQVERIGVQRALSAIGEADRILLVVDASAPEASDPSALWPEFLDFSPEPGKVTLIRNKADLTGEAIVLRCDNDGQATLSLCARSGEGLELLREHLKHCMGYEQTAESSFSARRRHLDALRLADEHLRHGHDQLTLAGAGELLAEDLRLAQQALGEITGAFSSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
Protein: TVA92_HUMAN
Sequence: MNYSPGLVSLILLLLGRTRGDSVTQMEGPVTLSEEAFLTINCTYTATGYPSLFWYVQYPGEGLQLLLKATKADDKGSNKGFEATYRKETTSFHLEKGSVQVSDSAVYFCALS
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor alpha variable 9-2.
What are the subcellular locations of this protein?
Cell membrane.
Protein: LEU1_STAA1
Sequence: MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQAIAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLASIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEYAHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAALEEVALALYVRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIHQDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSEKLKALGYNIDKEAQIDLFKQFKTIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVVKDKEGHIYQDSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGIDHDILQASCKAYVEAHAKFAAENVEKVGN
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: ARL4A_HUMAN
Sequence: MGNGLSDQTSILSNLPSFQSFHIVILGLDCAGKTTVLYRLQFNEFVNTVPTKGFNTEKIKVTLGNSKTVTFHFWDVGGQEKLRPLWKSYTRCTDGIVFVVDSVDVERMEEAKTELHKITRISENQGVPVLIVANKQDLRNSLSLSEIEKLLAMGELSSSTPWHLQPTCAIIGDGLKEGLEKLHDMIIKRRKMLRQQKKKR
What is the function of this protein?
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).  GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.  Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.
What are the official names of this protein?
ADP-ribosylation factor-like protein 4A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Nucleus, nucleolus. Note=Localization in the nucleolus is dependent by nucleotide binding.
Protein: IML2_LODEL
Sequence: MFKGIRKRASNLSIYAVTSNLSATNAPSDQQPASNSPSSYESILSQVHDFEIALKAMDYLLDDRTQQGTELLHEQAQLGSSDGKPHAIFPLALGVMEFIEATLGFEPEVMARAHKTLNDAESASTTNAKYNVRHQLATSNIYPPGTEFQVTLAESTLLNALLMLLTENNGMVESVKALYKLRKAYQTLDAVYKKIKELEPVFNRNLAKLRKAANKGLLEVPRLNGLVNGGTRLKHSISTVDLPGYESLGSSSSSSSATLPEDLKLMKNLEKIYLMRKARIEGTNLGNNTGVQHQPLNLFSDLASSIAMKQNGNGVETSLPIIPQYGKFNNGNEEQVEEQEEEGEGEEEEEENSDNEHFVDAVEELTIGDINSSSLADSSAQSILSSVETSPSEVQSTDMHLHVSTTDEFIHSGVQLCFGILQVVLSLIPPAIGKVLSIVGFKGERETGLKLLWKTAITSRNVHGELALLFLLMFYDGPVQFVDTGFRLPSANKLKNIINLENKTSVTDDEVELIKDSPESYTSQLLKRARHHFPHNALWILQEGRMLAAEGRLAQASTLMQNFTDNPNNKIQMQQIEALLIFDRATIYIYMHEYDKAARDLIYLIEINSWSKAVYLFMAAACYLERYRMVRMGLQSPQINADTKLSLNGDVELEAKKYSDLFTKYLNLSLSYVPGHGANAQKKGGLGGSGKQMPFDKFLLRKWKHIEQRKKRHPELSLADVVGTSLIHELIYFWNGYNRMSPQDFELALKLLGYSGAPNTELSANTLHNNYAKIEETEDEAMIRYFLQSVALRQLGKVKQGLGILDSHVISKYVISEVPQFRFHKMTYSPYLYPTAFYEKTMFVWLLRTSESTIKQDVGRAVHECKSYLKKAETVGEGDYELSNRTSMRIKAAGDRLDQLGSLSR
What is the function of this protein?
Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins.  Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
What are the official names of this protein?
Inclusion body clearance protein IML2.
What is the protein family that this protein belongs to?
Belongs to the IML2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized exclusively in cytoplasmic inclusion bodies under protein folding stress conditions.
Protein: ATPF_HELHP
Sequence: MKKIAFFVICVGFPSLIFASASIQESDFIQRVINFVIFVAILWYFAFDSIKGIFVNRRNAISARLQEVQENLHKAKREKETAQKRLEESKEKAKNIVNAAKQEAYLLEQKYNDQIKKDIETLKYALESNIEFERRKITHEAVDELLNKLIQSDDVQLNKEDYVNIITKRIS
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TMM78_HUMAN
Sequence: MWLDTRNLGIVISCWKGVCVPQTTTLEMFYNDNDRVEESSNSYQIRREFLLPACLPAFLSFSTSFSFFLSFLPLSLSLFLPFFPSFFLSLSLSPSFLPSFLRQGLALSPRLECDGAIMIHCSLNIPGSSDPPTSAS
What are the official names of this protein?
Transmembrane protein 78.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TTYH3_MOUSE
Sequence: MAGVSYAAPWWVSLLHRLPHFDLRWEATSSQFRPEDADYQQALLLLGATALACLALDLLFLLFYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAALNRTAEPNLQSLERQLAGRQEPLRAVQRLQTLLGTLLGYTAAIPFWRNPGVSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEEHSVLSGDILQYYLACSPRATNPFQQKLSGSHKALVEMQDVVAELLRNVPREHPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSIPHTWQQKRGPDDDGEEETAPGPRQAHDSLYRVHMPSLYSCGSSYGSEASIPAAAHTVSNAPVTEYMSQNANFQNPRCENTPLIGRESPPPSYTSSMRAKYLATSQPRPDSSGSGH
What is the function of this protein?
Probable large-conductance Ca(2+)-activated chloride channel.  May play a role in Ca(2+) signal transduction (By similarity).
What are the official names of this protein?
Protein tweety homolog 3, mTTY3.
What is the protein family that this protein belongs to?
Belongs to the tweety family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MUTL_RALSO
Sequence: MTAATPARRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLQIKLEEGGVRRIAITDNGGGIPVDELPVALMRHATSKIGSLEELESVATLGFRGEALASIASVAELTLTSRTAQDAHATQIIAQTGRVQPASGGVGTTVDVQHLYFNTPARRKFLKTEQTELGHCLEVIRRTALARPDVAISVHHNGKPLEHWNAAQADMRTAAVLGTEFARARLPFEEAAGELRLFGFAGLPTASRGRADHQFFYVNGRFVRDRLLTHAVRSAYEDVLHGDRFPAYVLCLELPPEAVDVNVHPSKIEVRFRDSRAVHQFVYHAVQRALSRHAGEQGDSLRTDIADAPEQPGATATPADNTTRWVNQMAARQTSLGIAQPRAEYLAMMRGGSAPQPSSRPAWMADVPSAATLFDGAASAPADAAPAQASEPAAAPQADDSDDAHPLGFAVAQLHGIYVLAQNARGMVLVDMHAAHERILYEQLKTALEARRIEVQPLLIPVTFAASPVEIGTAEEFGDTLDLLGFDISAVSPTTLAVRAVPTLLQKADAQALARDVLRDLQAYGGSRVLAERQNELLATLACHSAVRANRRLNLDEMNALLRQMEATERADQCNHGRPTWIQLTVADLDRLFLRGQ
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: RADX_MOUSE
Sequence: MSGESGQPQPGPSHAGLYLEHPERDQAGVPGGVIRRADSQRRRSWIQKVIEQITGSPRQCVTLSEVVPVTVLAVQRYLLEDEPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNFLVYQNILKVGIEMRISRVSCLYNEKRLGQGILCIDKVHCGESLDVISVETPFRNRAHEEKPERPLRGGKSHYLALWNNEDPYGDIWKTNKQPEEFNFNNIKIISLSHLELTWNSRKNFPALLVRVLHKSKLRYYGKPNKKMIEPYQTYLEVADSSGMVSVILWNALCPEWYKSLRVGLVLLLQDYTVKKSYPLRIQPDPADPQMKLISTMEICLNLRDPPTNIVIIPEKQLKSEWKLPKLINRFITRSELDDMPEKSICDVIGLLSFVGRVQRSKKKENSEDFWSYRWIHITDGTSEQPFIVQLFSTSQPEVFENIYPMTYFVCTQLKVVRNNSQVPKLLYLTTTNESRALTTGGHRGLPYTYDTKAKKIIQWIKTKTNLEAKNTVIGGYYPYPPVPETFSKYSRFIKAESLLTTISEVKKVIEDLQYREQKRIAIQGIITAIKYIPYKHSAGSAPAPEAFWNASRPSTSQAAGKEDHCHERGSKRSQDDRPMGSQHFQYTSKVLSLCAKRKILQGPSANPVPVPQPHSSAQMKGSKHNTPSQESSTAYTTGKSRRITNDRWESQLWQDKKFSLRDHLHYGHVDPESIPRKFILEHEKFLTQQFNSQPAKYIPPEGKPPKLDEFQSARSLGHFEVTILGLNHEIAIDVAFLPMYSPEDVQASQIDTFLTCMNFSCVYPPAAPLSGRLPDPKAVAGDIVKAAADLDRVHIIGILDICNLGNNKVEVCLQKIYTPE
What is the function of this protein?
Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability.  Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks.
What are the official names of this protein?
RPA-related protein RADX.
What are the subcellular locations of this protein?
Chromosome. Note=Recruited to replication forks.
Protein: PHNN_PSEA7
Sequence: MTGRLIYLMGPSGSGKDSLLQAAREPLALRGCRIVRRVITRSAEAVGEDAQAVTPAQFDTLERASAFAMSWRANGLCYGIPVQIDEWLAQGYDVLVNGSRGYLAQARRRYPDLLAVLLGVQPEVLRQRLLARGRESPEEIEARLARNAEFAAGLEGPLFQLDNSGELDDTVRALLAWLGGDRACA
What is the function of this protein?
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
What are the official names of this protein?
Ribose 1,5-bisphosphate phosphokinase PhnN, Ribose 1,5-bisphosphokinase.
What is the protein family that this protein belongs to?
Belongs to the ribose 1,5-bisphosphokinase family.
Protein: RDRP_I78AC
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEGMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: PAND_RENSM
Sequence: MIRTMFKSKIHRATVTHANLHYVGSVTVDKDLLDAADILPGELVAIVDVTNGSRLETYTIEGQAGSGVIGINGAAAHLVNIGDTVILISYAQMTTAEAREYLPSIVHVDAANKIVQLGTDPAEALTEGLNRPPFSTTA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSD_SHISS
Sequence: MRFAIVVTGPAYGTQQASSAFQFAQALIVEGHELSSVFFYREGVYNANQLTSPASDEFDLVRGWQQLNAQHGVALNICVAAALRRGVVDETEAGRLGLASSNLQPGFTLSGLGALAEASLTCDRVVQF
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.  Accepts sulfur from TusA and transfers it in turn to TusE.
What are the official names of this protein?
Sulfurtransferase TusD, tRNA 2-thiouridine synthesizing protein D.
What is the protein family that this protein belongs to?
Belongs to the DsrE/TusD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1470_METJA
Sequence: MFRKIVSKRGYIFTYEAIVIAFIFLSVFYIGYMVYSHNMLTALEEKKDTEKFHKALLLKDYFLRNNKFPGKFYNKTYLDNFTNELDIKEKTFDLFNNFSEYKGLIRFIIYPNIYDEELDNISDEICANDGLQAITYNFSSNTFKIYSNVNTTFNNANLSISGMDLIYFKENVYIPKITGMKYGDSINLYGCNGDHIYFKVNSEIISASARVVTNNGNPFITWQNWRYATPILIINNLNQNLNDYDVKIVFDSQSYINSGEMRTDCGDVRFVDEDGNPLSYWIEPNTIDTPHTVAWVKVNLAPNEHKLIYMLYGNPTATTTANGDNTFPLFFDDFSKGNLDNTKWTYNFNNPLFVNDTYPNGINFTYLSLDYTYYNNHNYIIYDINNTHISSISTYYPNTSVRFHANFHKKYEEWGGFYININGNDYNREVITNYHWGGEWLRAESSVLNQDYDSYIILQDPDLYDNWHTYEIQRDGGSSVNFIIDDAIYKTIYSNIYTGDLPISFYARKYDYSTKYGYYPVPQDEQNGNISIDWVFVRKYVEPEPTVTLLSSDVIFTVNGYIYKKPLKSVFDNIDITPNLNVGINEIRILSSPLPVEFLIKTNENTDFYYLTLSPNNVTIVVKP
What are the official names of this protein?
Uncharacterized protein MJ1470.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: EPFL2_ARATH
Sequence: MVWSSNMSSFLLILLILNSTHFSLMANGRPEPDSVEFTKSGDQDVKMMMRGLIGSRPPRCERVRCRSCGHCEAIQVPTNPQTKLHSPLTTSSSSSSETIHLDYTRGDDSTNYKPMSWKCKCGNSIYNP
What is the function of this protein?
Controls stomatal patterning.
What are the official names of this protein?
EPIDERMAL PATTERNING FACTOR-like protein 2, EPF-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: APT_PHOPR
Sequence: MIRNSIKSISDYPKPGILFRDVTSLMEDPEAYRATMQVLIERYSNTGITKVIGTEARGFLFGAPLALELGVGFVPVRKPGKLPREVISESYELEYGKDILEIHVDAIVEGDKVLLVDDLLATGGTIEATTKLARRLGGVVEDAAFVINLPDIGGAERLKGIGLNVFSICDFDGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.