PharMolix/UniProtQA huggingface dataset:
Protein: P2A_CFMVN
Sequence: MGCSVVGNCKSVMLMSRMSWSKLALLISVAMAAAMTDSPPTLICMGILVSVVLNWIVCAVCEEASELILGVSLETTRPSPARVIGEPVFDPRYGYVAPAIYDGKSFDVILPISALSSASTRKETVEMAVENSRLQPLESSQTPKSLVALYSQDLLSGWGSRIKGPDGQEYLLTALHVWETNISHLCKDGKKVPISGCPIVASSADSDLDFVLVSVPKNAWSVLGVGVARLELLKRRTVVTVYGGLDSKTTYCATGVAELENPFRIVTKVTTTGGWSGSPLYHKDAIVGLHLGARPSAGVNRACNVAMAFRVVRKFVTVENSELYPDQSSGPARELDAETYTERLEQGIAFTEYNISGITVKTSDREWTTAEALRVARYKPLGGGKAWGDSDDEDTQETAIRPLNYQRAGSLRGSPPLANLSSTRATSGVTKESSIPTACLSDPLESRVAGLEKLCAERFTEMFELLRQSSQNSKSSLGQAADRKQKSDRSSSKPEGLKESKRPPICNWQSLTSKPSTRGPDPAPVSAESPGVVKTSSQKSKRSRTRGKSTSRQVPASPSPKSGSATSK
What is the function of this protein?
Covalently attached to the 5' extremity of the genomic and subgenomic RNAs.  It may serve as a primer for the replicase.
What are the official names of this protein?
Polyprotein P2A.
What are the subcellular locations of this protein?
[Polyprotein P2A]: Host membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: [N-terminal protein]: Host membrane; Multi-pass membrane protein.
Protein: SARS_STAAS
Sequence: MKYNNHDKIRDFIIIEAYMFRFKKKVKPEVDMTIKEFILLTYLFHQQENTLPFKKIVSDLCYKQSDLVQHIKVLVKHSYISKVRSKIDERNTYISISEEQREKIAERVTLFDQIIKQFNLADQSESQMIPKDSKEFLNLMMYTMYFKNIIKKHLTLSFVEFTILAIITSQNKNIVLLKDLIETIHHKYPQTVRALNNLKKQGYLIKERSTEDERKILIHMDDAQQDHAEQLLAQVNQLLADKDHLHLVFE
What is the function of this protein?
Transcriptional regulator that controls expression of some virulence factors in a cell density-dependent manner.
What are the official names of this protein?
HTH-type transcriptional regulator SarS, Staphylococcal accessory regulator S.
What is the protein family that this protein belongs to?
Belongs to the SarA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_BACLD
Sequence: MFRIGQGFDVHQLVEGRPLIIGGITIPYEKGLLGHSDADVLLHTIADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLRHVWMIVKEKGYTLGNLDCTIIAQKPKMAPYIEDMRARIAEGLEAEISQINVKATTTEKLGFTGRAEGIAAQASVLLQKV
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: DADA_PSE14
Sequence: MRVLVLGSGVIGTTSAYYLARAGFQVTVVDRQPAAAMETSFANAGQVSPGYASPWAAPGVPLKAIKWLLQRHAPLAIKATADIDQYLWMAQMLRNCTASRYTVNKERMVRLSEYSRDCLDELRLETGIAYEGRSLGTTQLFRTQAQLDNAAKDIAVLEQSGVPYELLDRDGIARVEPALAGVTGILSGALRLPNDQTGDCQLFTTRLAEMAVELGVEFRYGQNIERLDHAGDRINGVWIDGKLETADRYVLALGSYSPQLLKPLGIKAPVYPLKGYSLTVPITNPAMAPTSTILDETYKVAITRFDNRIRVGGMAEIAGFDLSLNPRRRETLEMIVGDLYPQGGDLTQASFWTGLRPTTPDGTPIVGATPFRNLFLNTGHGTLGWTMACGSGRLLADLIARKTPRISAEGLDISRYGNTQENAQHVNPAPAHQ
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: RSMA_CORGB
Sequence: MEEPSGAQLLGPVEIRALAEKLDVTPTKKLGQNFVHDPNTVRRIVAAAELTPDDHVVEVGPGLGSLTLALVESAASVTAVEIDPRLAAELPETFQWRAPALAHKLSIVLKDALKVQQSDMEVQPTALVANLPYNVSVPVLLHMLEEFPTINKVLVMVQAEVADRLAADPGSKIYGVPSVKASFYGPVTRAGSIGKNVFWPAPKIESGLVKIVREDTAWKQDDETRKKVWPIIDAAFLQRRKTLRAALSGHYGSGQAAEEALRAADIDPTLRGEKLDVTDYVRLAGVLQQKDEK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_XANCP
Sequence: MTMPTKSFHRTDRVSAQVRRDLGTIVHAAVRDHGLPSVSVSDVEISRDLAHAKVFVTALQQERSAEAVKGLKEIAGQLRTQLARAMKLRHVPELHFHYDDSVDRGERIDNLLRDLDDIGPEAAPDAQDAEPR
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPPD_BACSU
Sequence: MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVGESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQDPMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFSGGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHDLGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAIPGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPPEAVKAKMRKLANTFEKPVLVREVE
What is the function of this protein?
Part of the binding protein-dependent transport system for oligopeptides.  Probably responsible for energy coupling to the transport system.  Required for sporulation and competence.
What are the official names of this protein?
Oligopeptide transport ATP-binding protein OppD, Stage 0 sporulation protein KD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RNFB_CERS4
Sequence: MIEAAVSMSALGLGLGLLLGVAARRFHVESPPIVDAIEGILPGTNCGACGYPGCRGLAEAMSEGAAPVTACAPGGRDVALALAAIVETDGGGGAVPGMAEAEPTVAFIFEDHCTGCMRCFKRCPTDAIIGANRQIHTVVTDACIGCNACIEACPTEAIVARVKPKTLKSWYWDKPRTAFEARGTEVAA
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cellular chromatophore membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MEND_LEUMM
Sequence: MTDTLTFNTKHLLEALFESGIRHFIVSPGSRSTPIALLLAEYAEQNNEIKLFVDVDERSAGFFALGIAKTLLEPVVLLGTSGTAIAEYMPAVAEAYAANIPLVVLSTDRPQELQFNGAPQTIPQSNLFGQLTKQAVLIRLQDMHSDVTEYIDFIVQKVVNLSITAPRGPIQINLPLRKPLMPVLDRQDEVHVQRVVFDKQSVQYRLPPITAKRLLILAGPNVLNSYDDSLKKFAIKNNVPVIADVLSQSRHTYTIHGIDVLLQAHKINADLKPDLVVRFGKTPVSARVLQWLKEENILTWHVDEDAGVDHTRHIVRAIKMAPHDFLESMHLTLSKNQIDFNQKWLSLPKVIKTRNEMNIITALDDAVPDDTHIFVANSMPIRDMDNFFTGNHTQRIYANRGANGIDGVISSALGMSAVVKQRSVLLTGDLTLFHDMNGLMMAKNYQLPLDIIVINNNGGGIFSFLPQAGAPKYFEQLFGTPLNIDIKKIADLYYIDYHQLNVPEALSQILQTPSKTTRLIEYKSDHQRNRDDHREVLEMLK
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: XERC_RHIME
Sequence: MKPPGPMMNELLAIGHPEVMAERRRWLASLAEERRLSEKTVDAYERDTRQFLTFLTGHLAGPPRLSDICALRPADLRGFLAQRRKGGAGARTLGRGLAGLRSFLRYLERNGLANAAGAGAVRSPKQPKSLPKALTDREALKVVTADAQLAEEPWIAARNAAVLTLLYGCGLRIAEALDLTPADFSGPVTSLRVTGKGGKTRIVPMIAAAAEAVETYRKLCPYHIEPEEPIFRGARGAKLQPAIIQREMQKLRAALGLPDSATPHALRHSFATHLLAGGGDLRTIQELLGHASLSTTQVYTGVDSARLLEIYDRAHPRA
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerC.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMC_ECOL6
Sequence: MKHYSIQPANLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNHLEARFPEHPHPLFVVAESGFGTGLNFLTLWQAFDQFREAHPQAQLQRLHFISFEKFPLTRADLALAHQHWPELAPWAEQLQAQWPLPLPGCHRLLLDEGHVTLDLWFGDINELTSQLDDSLNQKVDAWFLDGFAPAKNPDMWTQNLFNAMARLARPGSTLATFTSAGFVRRGLQEAGFTMQKRKGFGRKREMLCGVMEQTLPFPCSTPWFNRMGSNKQEAAIIGGGIASALLSLALLRRGWQVTLYCADEAPALGASGNRQGALYPLLSKHDEALNRFFSNAFTFARRFYDLLPVKFDHDWCGVTQLGWDEKSQHKIAQMLSMDLPAELAVAVEANAVEQITGVATNCSGITYPQGGWLCPAELTRNVLELAQQQGLQIHYQHQLQDLSRKDDGWLLNFAGDQHATHSVVVLANGHQISGFSQTSSLPVYSVAGQVSHIPTTPELAKLKQVLCYDGYLTPQNPANQHHCIGASYHRGSEETAYSDEDQQQNRQRLIDCFPQVQWAKEVDVSGKEARCGVRCATRDHLPMVGNVPDYDATLVEYASLAEKKDEAVSAPVYDDLFMFAALGSRGLCSAPLCAEILAAQMSEEPIPMDASTLAALNPNRLWVRKLLKGKAVKAG
What is the function of this protein?
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA.  Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
What are the official names of this protein?
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC, tRNA mnm(5)s(2)U biosynthesis bifunctional protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the DAO family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUP_MYCMM
Sequence: MAQEQTKRGGGGGDDEDVTGTTAAGQERREKLAQDTDDLLDEIDDVLEENAEDFVRAYVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: MAJIN_MOUSE
Sequence: MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVIVQELEDSIRAVLANMDSLQPFVTEHFIVFPYKSKWERVSHLKFKHGESILTPYPFVFTLYIEMKWFAEDLPSGKPADDIPLELVLAETEAEEATMRKWKRKLMEEPSSPSRQGPHRAKMETSSEASSNKKPLKESKRSTDEEAQQEYQDTPASNAIAVKEQDAALGHGLQGLVVPPLQHSSPPPPKEPGARGFLGFLSALFPFRYFFKKSGQ
What is the function of this protein?
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis.  Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex.  During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA.  In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane.  MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.
What are the official names of this protein?
Membrane-anchored junction protein.
What is the protein family that this protein belongs to?
Belongs to the MAJIN family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Single-pass membrane protein. Chromosome, telomere. Note=Localizes to telomeres throughout meiotic prophase I and disappears in metaphase I. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane.
Protein: HEMA_I83A8
Sequence: MKTIIALSYIFCLVFAQKLPGNDNSTATLCLGHHAVPNGTLVKTITNDQIEVTNATELVQSSSTGRICDSPHRILDGKNCTLIDALLGDPHCDGFQNEKWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFINEGFNWTGVTQSGGSYTCKRGSVNSFFSRLNWLYESESKYPVLNVTMPNNGKFDKLYIWGVHHPSTDKEQTNLYVRASGRVTVSTKRSQQTVIPNIGSRPWVRGLSSRISIYWTIVKPGDILLINSIGNLIAPRGYFKIRTGKSSIMRSDAPIGICSSECITPNGSIPNDKPFQNVNKITYGACPRYVKQNTLKLATGMRNVPEKQTRGIFGAIAGFIENGWEGMVDGWYGFRHQNSEGTGQAADLKSTQAAVDQINGKLNRLIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRKQLRENAEDMGNGCFKIYHKCDNACIGSIRNGTYDHDVYRDEALNNRFQIKGVELKSGYKDWILWISFAISCFLLCVVLLGFIMWACQKGNIRCNICI
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: FRPD4_HUMAN
Sequence: MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQIIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTTFIGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEADYRSLAQRSLLTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLDLTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAILNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSLQNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNETNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLPPKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQGTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASGLGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARLCDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIPSEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV
What is the function of this protein?
Positive regulator of dendritic spine morphogenesis and density.  Required for the maintenance of excitatory synaptic transmission.  Binds phosphatidylinositol 4,5-bisphosphate.
What are the official names of this protein?
FERM and PDZ domain-containing protein 4, PDZ domain-containing protein 10, PSD-95-interacting regulator of spine morphogenesis, Preso.
What are the subcellular locations of this protein?
Cell projection, dendritic spine.
Protein: PTH_STAA1
Sequence: MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_NITEC
Sequence: MLVLGIETSCDETGVALYDTRRKLLGHALYSQVDMHRDYGGVVPELASRDHIRRVLPLVTQVLEQTNTSLETIDAIAYTQGPGLAGALLTGASISNALAFARNIPVLNIHHLEGHLLSPLLSDPAPDFPFVALLVSGGHTQLMHVKGIGQYKLLGETVDDAAGEAFDKTAKLLGLDYPGGKLLADLATQGQPGRFKLPRPMLNSDDLNFSFSGLKTAAALLINKQKANTQTRADIALAFEDAVTDVLVKKSIAALKITRLQQLVVAGGVGANSRLRQKLRHHLVGTGIAVFFPELEFCTDNGAMIALAGALRLQQLNEKPPGSDGSFTIKARWNLEDL
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TFE_METM5
Sequence: MLENPLIQQVLFEIMDEDVVGFDVLSVLINTNEVTDDEISRQLDVKLNNIRRILYKLYEARLVDYNREKDEETNWYTYTWKPSLEKVPALVAKKMKNVLNGLKEQLEMEETNMFFFCSDCEIKFTFEDAMDSGFRCPQCGGMMYEYDNKKDISLLKEQINYLEDEFTKNPLFSAY
What is the function of this protein?
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase.  Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment.  Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal.  It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes.  Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
What are the official names of this protein?
Transcription factor E, TFE, TFIIE subunit alpha homolog, Transcription initiation factor TFIIE.
What is the protein family that this protein belongs to?
Belongs to the TFE family.
Protein: QUED_PYRAB
Sequence: MKRVVSIKRRIYWTKEFDSSHFLELEYESKCRRLHGHTYRVEVEIEGEPNEHGMIFDFNHLSELIKTLDHKVIVSEKWVRYEEGYVLIEKNDKLLKLPRSEVVVIDKPNVTAEYIAEWISERILENAGENVREIRVRVWEDPRSYAEITLTLKPQGS
What is the function of this protein?
Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
What are the official names of this protein?
Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase, CPH4 synthase, Archaeosine biosynthesis protein QueD.
What is the protein family that this protein belongs to?
Belongs to the PTPS family. QueD subfamily.
Protein: SPEE1_CALS4
Sequence: MELWFTEHQDENLRFSIKVKETLVVEKTPYQHLAILDSYQFGRVLVLDGILQTTEKDEFVYHEMIVHVPLFTHKNPKDVLIIGGGDGGSVREVLKHSSVERVVLAEIDEAVIRNSKKYLPTISSALDDPRVEIMIGDGIKYVNEHKNEFDVVIVDSTDPIGPAVGLFTSDFYRAVYECLREDGIIVAQTESPFIYGKLINKISKMFKEIYPITKAYIATVPTYPGSLWTFTMGSKKYDPEEVDINSIPRIQTKYYTPEIHKAAFVLPKFVKDIFDEV
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase 1, Putrescine aminopropyltransferase 1, PAPT 1, Spermidine synthase 1, SPDS 1, SPDSY 1.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UCHL5_PIG
Sequence: MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGSNMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK
What is the function of this protein?
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains.  Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome.  Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH-L5, Ubiquitin thioesterase L5.
What is the protein family that this protein belongs to?
Belongs to the peptidase C12 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus (By similarity).
Protein: MCRI1_DANRE
Sequence: MTSSSTPRMHTYKRTSSPRSPTNTGELFTPAHEENVRFIHDTWLCVLRDIKCPQNHERNDRGPQEYVEKNPNPNLHSFIPVDLSDLKKRNTQDSKKS
What is the function of this protein?
May play a role in the regulation of the epithelial-mesenchymal transition.
What are the official names of this protein?
Mapk-regulated corepressor-interacting protein 1, Protein FAM195B.
What is the protein family that this protein belongs to?
Belongs to the MCRIP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, Stress granule.
Protein: RS3_LEUCK
Sequence: MGQKINPTGFRVGVIRDWDAKWFADKADYANQLHEDLRIRKYIEKNLADAAVDRIEIERSTKSRVDVSVHTAKPGMVIGKGGSEVEKLRTQLAKLTDRDEKGRSKRVFINIVEIKKPDLSAHLVGQQIAGDLERRVAFRRAMRGAIQRATRSGAKGIKVMVSGRLNGADIARIEQYTEGTVPLHTLRADIDYSWDEAMTAYGNLGIKTWIYRGDILPQKKNSK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: SYM_OCEIH
Sequence: MARENAFYITTPIYYPSGKLHIGNAYTTIACDVMARYKRMRGFDVFYLTGSDEHGQKIEQKAKEMNISPKAYVDDMAEGMKKLWNTLEISNDKFIRTTEEQHKKVVADIFERFLEQGDIYLDEYEGWYSVPDETFYTETQLEDVERDDDGNVIGGKSPDSGHPVELIKEESYFFRMSKYADRLLKFYEDNPEFIQPESRKNEMINNFIKPGLEDLAVSRTTFSWGVQVPSNPKHVVYVWIDALTNYITALGYGSEDTSLYDKFWPADVHMVGKEIVRFHTIYWPIMLMALDLPLPKKVFAHGWLLMKDGKMSKSKGNVVYPEMLVERYGLDALRYYLMREVAFGSDGVFTPEDFISRVNYDLANDLGNLLNRTVAMINKYFDGKVPEFKGEVTSFDGELQTTANNAVKEYEKHMEGMQFSDALKQVWILISRANKYIDETEPWIVAKDEGRRNELASVMVHLAESLHAAALMLQPFLTHAPKKIAEQLGLGEEYGLDWGTIGFGNFPENTTVVKKGTPIFPRLDLDEEAAYIRDQMANGANAASSEDETGDWDPNETDLVSEKEKQIKYDVFDKVELKVAEVKDCSKVEGADKLLKFRLDAGDNGDRQILSGIAEYYSEPEQLIGKKVVIVANLKPRKMRGEISQGMILSAEYDGKLQIVEAPSEAPNGSSIS
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.