PharMolix/UniProtQA huggingface dataset:
Protein: THYX_KOSOT
Sequence: MEIKVLEKGFIRLVEVMGDDFSAVQAARVSYGKGLTTPERDKKLIFYLMEHGHHSPFEHIIFKFHIKLPIFVMRQLVRHRIASINERSGRYTEFSDEWYIPERIRTPDKVNRQGSVFVDDDDLNSEGIRLIEETIEKTYQAYKRLLEMGVARELARIVLPTSMYTECYWTINARSMMNFLNLRADSHAQYEMQQYALAVAKIFKSKCPVTYEAFLNFAYTGDLLKTEGCL
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
What are the official names of this protein?
Flavin-dependent thymidylate synthase, FDTS, FAD-dependent thymidylate synthase, Thymidylate synthase ThyX, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase ThyX family.
Protein: CH601_PROMP
Sequence: MPKQLSFSNESREALEKGINTVANAVKVTIGPKAKNVVIERKFGSPDIVRDGSTVAKEINLDNPISNLGAKLIEQVASKTKESAGDGTTTATILTQIMVQEGLKNIAAGASPIELKKGMEKGLNFVLEKLRSKSIKINGSDIKKVATVSAGGDEDIGSIISKAMDIVTSDGVITVEESQSLETELDITEGMSFDRGYSSPYFVTDQERQICELENPKILITDQKISTLTNLVPILEEVQKSASPFLILAEDIEGEALTTLVLNKNSGVLNVSAVRAPSFGERRKAALEDIAILTGAKLISEDQSMKLEEVTLNDLGKAKKITISKDKTTIVAFDDTKDLVQERVEKLKREVEITESEYDKDKINERIAKLAGGVALIKVGAATETEMKYKKLRIEDSLNATKAAIEEGVVSGGGQTLIEISNELSNSRKEISDDLTTGIDIITNALLEPTKQIAKNAGFNGDVVIADIKRLGKGFNANNGEYENLNESGILDPTKVIRLALQDSVSIAAMIITTEVAVADIPEPEAAPGGPGADPMGGMGGMGGMGGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KTHY_BACC2
Sequence: MKGLFVTIEGPEGSGKTTLIKSLLPYFEQKAQKVMATREPGGIAISEDIRTILHKQEYTMMEARTEALLYAAARRQHLVEKVMPALNENYLVLCDRFIDSSLAYQGYARGLGMDKVFEINRFATEDCMPSLTIYLDIEPEVGLARIEKDAGREVNRLDMEDISFHKRVREGYLQVVERFSDRIVLVNADQPMEKLIEEVVQIIEDKLL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: 6PGL_YERPA
Sequence: MKQAVYVASPDSQQIHVWQLDSAGELTLLQTVDVPGQVQPMAISPNQRHLYVGVRPDFGIVSYHIADDGTLTAAGMAPLPGSPTHIDTDRQGRFLFSASYSFNCVSISPIDTHGVVQAPIQQLDDLPAPHSANIDPTNQILLVPCLKEDKVRLFDLSAEGQLTPHAQADITVAAGAGPRHMAFHPNHQVAYCVNELNSSVDVYQISNNGQEYHLVQSLDAMPADFTGTRWAADIHITPNGRYLYISDRTANLLGIFTVSEDGRVISLVGHHLTEAQPRGFNIDHSGNFLIASGQKSDHIEVYRIDQNTGELTTLKRYPVGKGPMWVSIRGAQNS
What is the function of this protein?
Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
What are the official names of this protein?
6-phosphogluconolactonase, 6-P-gluconolactonase.
What is the protein family that this protein belongs to?
Belongs to the cycloisomerase 2 family.
Protein: GPMA_BURL3
Sequence: MYKLVLIRHGESTWNKENRFTGWVDVDLTEQGRNEAYQAGELLKEAGYTFDIAYTSVLKRAIRTLWHVQDKMDLMYLPVVHSWRLNERHYGALSGLNKAETAAKFGDDQVLVWRRSYDTPPPALEATDERAPFNDPRYAKVPREQLPLTECLKDTVARVLPLWNESIAPAVRAGKQVLIAAHGNSLRALIKYLDGISDSDIVGLNIPNGVPLVYELDENLKPIKHYYLGDQDAIAQAQAAVAKQGKAG
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: APT_BACTN
Sequence: MIMSKETLIKSIREIPDFPIPGILFYDVTTLFKDPWCLQELSNIMFEMYKDKGITKVVGIESRGFIMGPILATRLNAGFIPIRKPGKLPAEVIEESYDKEYGTDTVQIHKDALDENDVVLLHDDLLATGGTMKAACELVKKLKPKKVYVNFIIELKDLNGKSVFGDDVEVESVLTL
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_ALIF1
Sequence: MTKLTVKALSEEIGTPVDRLLQQFSDAGINKKDGDSVTESEKQSLLVHLKKEHGSVDDSASPTRLTLQRKTRSTLSVAGSGGKSKDVQVEVRKKRTYVKASALEEEKKAEQLKAEAEEQAKRDAEEAAVRELEQKAQREAEEQAKREAEAEAKAKREAEEKAKRAEADKAKKEMTKKNEQAKKEAEELKARQELEATRKAEAEAAKLVEEARKLAEENEARWKEEEQKKSAAEKDADYHVTTSSHAREAEDAADRKEEQQPRRRKKKAKPAEAAAPRGGRNQRGGRNKKAQVNKPTSMQHGFDKSATVAKQDVAIGETIVVSELASKMSVKATEVIKVMMKMGAMATINQVIDQETAQLVAEEMGHKVILRKENELEEAVLSDRDNSAEAEGRAPVVTIMGHVDHGKTSTLDYIRRAHVADAEAGGITQHIGAYHVETDNGMITFLDTPGHAAFTAMRARGAQATDIVVLVVAADDGVMPQTIEAIQHAKAAGVPLIVAVNKIDKEDANPDNVKNELAQYDVIPEEWGGENMFVHISAKQGTNIDGLLEAILLQSEVLELTAVREGMASGVVVESRLDKGRGPVATVLVQSGTLNKGDIVLCGQEYGRVRAMRDENGKEIESAGPSIPVEILGLSGVPASGDEATVVRDERKAREVANYRQGKFRDVKLARQQKAKLENMFSNMTAGEVAELNVVLKADVQGSVEAIADSLRKLSTDEVKVNIVGSGVGGITETDAVLAAASNAIILGFNVRADATARRTIENENLDLRYYSIIYQLIDEVKAAMGGMLAPEFKQEIIGLAQVRDVFKSPKLGAIAGCMVTEGTIKRSNPIRVLRDNVVIYEGELESLRRFKDDVAEVKNGYECGIGVKNYNDVRVGDQIEVFEIVEIKRTLD
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2420_STAAN
Sequence: MKKLAVILTLVGGLYYAFKKYQERVNQAPNIEY
What are the official names of this protein?
Uncharacterized protein SA2420.1.
Protein: LPXB_PSET1
Sequence: MNKDQKQLRIGIVAGELSGDILGEGLIKALKKHFPDAIFEGIAGPKMQAQGCNTLYDMDELSVMGLVEVLGRLPRLLKIRKQLVQHFIDNPPDVFIGIDAPDFNLRVEKPLKDAGIKTVQYVSPSVWAWREKRIHTISAATNLVLALLPFEKEFYDKHQVPCTFVGHTLADDIALEHDDSKARKELGLSPDDKVLALLPGSRGSEVGLLSETYIKTAVQLQAQNPALKIVVPLVNAKRKAQFTEILNATAPTLKISLLDGQSKQAMQAADAILLASGTATLEGMLYKKPMVVGYKIKPLSYWIFKTLFTFNIKYFSLPNLLADEELVPEFLQSECNVANLTQALTPMLNTDNQALKARFLAIHKKIRLNASEQAANAVAELINAN
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: CH60_CITBB
Sequence: MAAKIIKFDQEARNCILKGVNTLADAVKVTLGPKGRNVVIEKSYGAPLITKDGVTVAKEIELEDKFENMGAQLVKEVASKTSDVAGDGTTTATVLAQAIYRQGAKLVAAGHNPMEIKRGLDQAVEALVAELKNISKPIKDHKEIAQVGTISANNDKTIGDIIAEAMEKVGKEGVITVEEAKAMETTLETVEGMQFDRGYLSPYFVTDPERMEAAMDNVAILIHDKKIANMKDLLPVLEQTAKSGRPLLIIAEDIEGEALATLVVNKLRGVLNVCAVKAPGFGDRRKAMLEDIAILTGGKVISEEVGFKLENTTLDMLGQAKKITVDKDNTTIIDGYGAEADIQGRVKMIRAQIDETSSDYDREKLQERLAKLVGGVAVIKVGAATEIEMKEKKARVEDALHATRAAVDEGIVPGGGVAYLRALKVLEKLQLAPEQQFGVNVIKRALEEPIRQISQNAGVDGSIVVDKVKNGKDAFGYNAADDVYVDMIEAGIIDPTKVSRSALQNAASVAGLMMTTEAMIADKPKEEGAMPAMPGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_LEGPH
Sequence: MINEIKQDSEKRMKKTIEALHTDMSKIRTGRANASLLDHVMVDYYGSPTPLSQVANITTSDSRTILVTPWEKSMVAAIEKAILNSDLGLNPATAGTAIRVPMPPLTEERRKELIKVVRHEGEQGRVSIRNIRRDANNQLKELVKEKAISEDDERRAAEAIQKLTDRYISEVDAVLAEKEKDLMEI
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACT7_SOYBN
Sequence: MADAEDIQPLVCD
What is the function of this protein?
Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
What are the official names of this protein?
Actin-7.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: MNMA_CHLTB
Sequence: MRKTVIVAMSGGVDSSVVAYLLKKQGEYNVVGLFMKNWGEQDENGECTATKDFRDVERIAEQLSIPYYTVSFSKEYKERVFSRFLREYANGYTPNPDVLCNREIKFDLLQKKVLELKGDFLATGHYCRGGADGTGLSRGIDPNKDQSYFLCGTPKDALSNVLFPLGGMYKTEVRRIAQEAGLATATKKDSTGICFIGKRPFKSFLEQFVADSPGDIIDFDTQQVVGRHEGAHYYTIGQRRGLNIGGMEKPCYVLSKNMEKNIVYIVRGEDHPLLYRQELLAKELNWFVPLQEPMICSAKVRYRSPDEKCSVYPLEDGTVKVIFDVPVKAVTPGQTVAFYQGDICLGGGVIEVPMIHQL
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 2ADD_HETMG
Sequence: MNRLIVLFLIVTMICATIAVPSREELEDQKEYKRSAALAGTIIEGASLGFQILDKVLGELGKVSRKIAVGVDNESGGSWTALNAYFRSGTTDVILPEFVPNQKALLYSGRKDTGPVATGAVAAFAYYMSNGHTLGVMFSVPFDYNFYSNWWDVKVYSGKRRADQGMYEDMYYGNPYRGDNGWHQKNLGYGLRMKGIMTSAGEAILQIRISR
What is the function of this protein?
Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and cytolysis.  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers.
What are the official names of this protein?
DELTA-stichotoxin-Hmg2a, DELTA-SHTX-Hmg2a, Cytolysin III, Cytolysin-3, HMg III, HMgIII, Magnificalysin III.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
Protein: CAIE_ECOLU
Sequence: MSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFRGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQMEENRPRLQGTTDVMPKR
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: LIPA_THET8
Sequence: MKPKFETVELLSPTGEVVELKVVKRGLAQARPEPVDRNKPAWIKAPLPTGPRYQALKAMVRELRLHTVCQEALCPNIGECWTHGTLTVMILGDICTRACKFCAVHTGNPKGLVDPEEPRRVAEAIARMGVRYVVLTSVDRDDLPDGGASHFAATIRAIKERAPGVLVEALTPDFQGDLKAVETVLAANPEVYAQNLETVRRLTPKVRDPRAGYEQTLKVLAHAKKVRPDILTKSSLMLGLGETEEEILEAMRDLRAAGVDILTLGQYLRPTPAHLPVARYVPPEDFKRYEAWGYELGFREVFAGPLVRSSYRADRVFLEATQR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPN12_SCHPO
Sequence: MSTLDLNHLADLYDRKDWNACKKELLKLKVELAKQNLFVPTSDKEKASFARNVFEYGVLVSIQTCDIESFARYASQVIPFYHDSLVPSSRMGLVTGLNLLYLLSENRIAEFHTALESVPDKSLFERDPYVEWVISLEQNVMEGAFDKVASMIRSCNFPEFSYFMKIVMSMVRNEIATCAEKVYSEIPLSNATSLLYLENTKETEKLAEERGWDIRDGVIYFPKEANALETEDGMLIDEEDELELPPTASKHTISSIRQLLSYTSELEQIV
What is the function of this protein?
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
What are the official names of this protein?
26S proteasome regulatory subunit rpn12.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S14 family.
Protein: YAAA_ECO57
Sequence: MLILISPAKTLDYQSPLTTTRYTLPELLDNSQQLIHEARKLTPPQISTLMRISDKLAGINAARFHDWQPDFTPENARQAILAFKGDVYTGLQAETFSEDDFDFAQQHLRMLSGLYGVLRPLDLMQPYRLEMGIRLENARGKDLYQFWGDIITNKLNEALAAQGDNVVINLASDEYFKSVKPKKLNAEIIKPVFLDEKNGKFKIISFYAKKARGLMSRFIIENRLTKPEQLTGFNSEGYFFDEASSSNGELVFKRYEQR
What are the official names of this protein?
UPF0246 protein YaaA.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: MURD_ZYMMO
Sequence: MITSPVFSGQFYAVLGLARSGMATVAALLASDAKVMAWDNNPETRDRLQQQYQEAIDKGRLVISDPMIADIFGISAFVVSPGIPINRHPIAALAKERGIPIIGDIELFAQAHGFWERHGRRCPVVGITGTNGKSTTTALIHHILKEAGLPTLMGGNIGLPLLAADPLPDGGVYVLELSSYQIDLTFTLDCDIAVLTNITPDHLDRHGGFEGYRKAKERLFLLQSSPHYAVIATDDIPSQVIAKQSAAHLVTVHADNISAEDQVNWPNLQGPHNAQNAVLAMAVAHILGISDDVISKALISYAGLPHRMQKIGERRGVLFIDDSKATNAMATAPALAAFPAIHWILGGVPKTADLDPCKAFYNHIRQAYTIGQAGPDYAQLLREAGVNVVECGTLEKAVRLAAEEAQPDEVVMLTPACASFDQFSDYEARGQAFKKIVEALD
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_BRUA4
Sequence: MTLKARVIPCLDVKDGRVVKGVNFVDLIDAGDPVEAARAYDAAGADELCFLDITASSDNRETIFDVIARTAEQCFMPLTVGGGVRQVSDIRKLLLAGADKVSINTAAVKNPEFVAEAADKFGDQCIVVAIDAKKVSGEGEADRWEIFTHGGRQTTGIDAVEFAQKVVSLGAGEILLTSMDRDGTKAGYDVALTRAVADSVRVPVIASGGVGNLDHMVAGIRDGHATAVLAASIFHFGTYTIGEAKRYMAEAGIPMRLDPVR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBS_RABIT
Sequence: MPSETAQAGEGPAGCPHLSGAQGSDRSLDQRPPGNKDAPERVWIRPDVPSRCTWELGRPVADSPHQHAALAKSPKILPDILQKIGDTPMVRINKIGKNFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERAGTLRPGDTIIEPTSGNTGIGLALAAAVKGYRCIIVMPEKMSLEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKQEIPNSHILDQYRNASNPLAHYDTTAEEILQQCDGKLDMLVASAGTGGTITGIARKLKEKCPGCQIIGVDPEGSILAEPEELNQTEVTAYEVEGIGYDFIPTVLDRTVVDRWFKSTDKEAFAFARMLIAQEGLLCGGSAGSAVAVAVKAAQELQEGQRCVVILPDSVRNYMSKFLSDRWMLQKGFLEEEELSVKRPWWWHLRVQELSLSVPLTVLPGVTCSDTIDILRGKGFDQAPVVDETGEILGMVTLGNMLSSLLAGKVQPSDQVCKVLYKQFKQIRLTDTLGALSHILEMDHFALVVHEQIQYGGDEQPSKRQTVFGVVTAMDLLHFVASRGQDQQ
What is the function of this protein?
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine.  This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity).  Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).
What are the official names of this protein?
Cystathionine beta-synthase, Beta-thionase, Serine sulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the cysteine synthase/cystathionine beta-synthase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: COX1_NEUCR
Sequence: MSSISIWTERWFLSTNAKDIGVLYLIFALFSGLLGTAFSVLIRMELSGPGVQYIADNQLYNAIITAHAILMIFFMVMPALIGGFGNFLLPLLVGGPDMAFPRLNNISFWLLPPSLLLLVFSACIEGGAGTGWTIYPPLSGVQSHSGPSVDLAIFALHLSGVSSLLGSINFITTIVNMRTPGIRLHKLALFGWAVVITAVLLLLSLPVLAGAITMLLTDRNFNTSFFETAGGGDPILFQHLFWFFGHPEVYILIIPGFGIISTTISAYSNKSVFGYIGMVYAMMSIGILGFIVWSHHMYTVGLDVDTRAYFTAATLIIAVPTGIKIFSWLATCYGGSIRLTPSMLFALGFVFMFTIGGLSGVVLANASLDIAFHDTYYVVAHFHYVLSMGAVFAMFSGWYHWVPKILGLNYNMVLSKAQFWLLFIGVNLTFFPQHFLGLQGMPRRISDYPDAFSGWNLISSFGSIVSVVASWLFLYIVYIQLVQGEYAGRYPWSIPQFYTDSLRALLNRSYPSLEWSISSPPKPHSFVSLPLQSSSFFLSFFRLSSYGEQKEISGRQN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I, Cytochrome c oxidase subunit Cox1.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ARLY_BURMS
Sequence: MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISADDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPGFTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRDFAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKVCDARGIDLADLTLDEMKQELPNVAHLIGEDVFDYLTLEGSVASRNHPGGTAPDQVRAAAKAARAALGQ
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS15_STREM
Sequence: MAISKEKKNEIIAQYARHEGDTGSVEVQVAVLTWEINHLNNHIKEHKKDHATYRGLMKKIGHRRNLLAYLRRTDVNRYRELIQSLGLRR
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RR4_TOXGO
Sequence: MKKKFRTKLKKLQYFKLTFLPGFCTKLLKKELVPIKKGKTSSFRIQLLEKQKLKYNYRLKENQIKKYFKYIKLLKIFNLIQIIELRLDATIFRLGFAKSINQARQLITHGFIFINSILVKKPSFILTEKDLIYINPKKFTIILICRINLFFRYYNKYNLYIYTLCVEYLKFKLQKEFYFKLYLFIPFDENLIKYYYKF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
What are the official names of this protein?
Apicoplast 30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, apicoplast.
Protein: SFH5_ASHGO
Sequence: MPSDMLQFPSENDRQTFERLVSELPDLIHKRCHDYDELYGHKLLEEGPAEVAKFYSKDHAHALLFKFLKANAFSYEGAVKQLVSTLNWRREFQPLKAAFAEEHDERLMAAGYISYDASAAPNTRTVTWNLYGKLGACKDLFADQDTFIRYRVGLMERGLQALNLLDPDNCSMTQVHDYKDVSVWNMNADVKKCSRRVIAIFQDHYPELLYAKYFVNVPTILRWVYDVVRAFVSEETSRKFVVLNDGTKLAAYFAGVPAAYGGTAPATLAELPKPASRPSPYALFLLQKHISEELD
What is the function of this protein?
Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity.  Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.  Heme-binding protein that may play a role in organic oxidant-induced stress responses.
What are the official names of this protein?
Phosphatidylinositol transfer protein SFH5, PITP SFH5.
What is the protein family that this protein belongs to?
Belongs to the SFH5 family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: TEG7_GAHVM
Sequence: MQTSSRTYDYRRLKAEYKQLSASSSTDKAMHRLREAVHAVNILLPTPITLEMALLSADGVRKLVRGQSLARTYSACLRNLECLSRHVPGRGNPGLDAVVETHRENAQRVADTCAAALLHMYMSIGTGRTDAFVEHAIQLTAATETAMSDIALVERALGLTHPHNERSPASMDESTGMKNCAVLSHMNDNKDDAVNMEPGYNTTIDRLISSPLLSQSKRERTIISTPAVTPKDNCPPVKFSRENNLITEL
What is the function of this protein?
Plays several roles during the time course of infection, including egress of virus particles from the perinuclear space and secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes.
What are the official names of this protein?
Tegument protein UL51 homolog.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL51 family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host Golgi apparatus.
Protein: IF1_VIBVY
Sequence: MAKEDVIEMQGTVLDTLPNTMFRVELENGHVVTAHISGKMRKNYIRILTGDKVTVEMTPYDLSKGRIVFRAR
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.