PharMolix/UniProtQA huggingface dataset:
Protein: DNAJ_PARL1
Sequence: MSKRDFYDVLGVSRNASADELKKAYRSLAKKYHPDQNQGDKEAEQRFKELNEAYDALKDEQSRAAYDQFGHAAFDGGMGARGGPGGMGGFGAGASMSDIFDDLFGEFMGGRGGRGGRRGDGGQTRGHDLRYNMEISLEEAFEGKKAQVRVPGSVACEVCTGTGAAPGSSPITCPTCQGHGKVRASQGFFTIERTCPTCHGRGQTIDKPCTNCHGAGRVEKERTLSVNIPAGVEDGTRIRLSGEGEAGMRGGPAGDLYIFLSVKPHRLFERDGADLFCRVPIAMVTATLGGEIEVPTLGGKKVKVKVPEGAQTGRQFRLRGKGMPVVNSRETGDLYIQITVETPVNLTKKQKELLKEFEQASTPGNNPESAGFFAKVKEFWDGFQN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRF_BORAP
Sequence: MEDYKAFLDEKMSKVLLSLDNEYKTLRTGRISSNIFDKIFIQYHGQRTPITQVSSIRIPEARLVVIQPWDKTILNKIEQAILNSDLSMNPSSDGSVIRIKVPALTSERRQDIVKHAKKIAEEHKISTRNIRQDLNNKVKKQEKESEITEDSLKRILDDIQKSTDIYIKKIDAILESKIQEIMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_STRAW
Sequence: MSRIGKLPITVPAGVDVTIDGRTVQVKGPKGSLSHTIAAPIEIAKGEDGVLNVTRPNDERQNKALHGLSRTLVANMITGVTQGYVKKLEISGVGYRVLAKGSNLEFSLGYSHSITVEAPEGITFKVEAPTRFSVEGIDKQKVGEVAANIRKLRKPDPYKAKGVKYEGEVIRRKVGKAGK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: Y4136_MICAN
Sequence: MLIRHNRSSIAKPILLFLGCLVIGQLGVLVVANSLWFTEMGYLNTFLKQLSWQLGLGWGSAILSLLFIFTNLRLAQRFRWQKAKEDSYPLSPQSPSINLLGLLIIATGIGAWIGSMLLYYSKLALSLWTPDFNLPNLSSSLSSPLEIVWIRQVLTDISSNLWQGLIIAFLVLGLLIKTEYFLRIISIVFTVMLSFIIAGQWANFLKYFYGVPFNINDPQYGNDLGFYIFQLPLWQLLELWLTGVGIYTLFAVILTYLFSADSLSLGTFPGFSRPQLRHLYALWSGLMGLLVLHHIIQRYLLLYSPEGVVYGAGYIDVHVGQFIEIILGIIAGITSIWLGEKALFGKKDRRKLYKNTKKKLVFFPYLVPVFLYLIVWISGTIISGLLQRTVVQPNELVRERPYIERSIQSTRAAFSLDRIDAQVFDPQAELNAEVLERNHLTIDNIRLWDTKPLLETNRQLQQIRLYYKFPDADIDRYRVRVGLPEKIEERQISEKQQTIIAARELDYSAVPTSANTWVNKHLVYTHGYGFTLSPVNLVAAGGLPYYFVKDIGTNKDEGALQTSSELIDYSIPIGKPRIYYGELTNNYVMTPTTVEELDFPSGDGNVYNTYDGKGGILVGTGWRRWLFALYLRDWQMLFSQDFTPETRLLMRRDIQNRVQTIAPFLNYDRNPYLVAADVGDSSSKLHWIIDAYTISNRYPYSDPGKDKFNYIRNSVKVVVDAYHGTVNFYVADENDPIIQTWSKIFPHLFKSLAEMPKTLRSHIRYPEDLFSTQAERLLTYHMTDPQVFYNREDQWEIPLEIYGTEPQAVSPYYLIMKLPDSDKEEFILLHPYTPSSRQNLIAWLAARSDDREYGKLLLYQFPKQRLVYGPNQIEALINQDPDISQQISLWNRDGSKVLQGHLLIIPIEQSLLYVEPLYLVADQNSVPTIARVTVAYQNKIVMEPTLKEALEKLFSGDQS
What are the official names of this protein?
UPF0182 protein MAE_41360.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SGMR2_MACFA
Sequence: MGVPATRRCVEWLLGIYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLISVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
What is the function of this protein?
Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells.  Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation.  May play a role as a regulator of cellular cholesterol homeostasis.  May function as sterol isomerase.  May alter the activity of some cytochrome P450 proteins.
What are the official names of this protein?
Sigma intracellular receptor 2, Sigma-2 receptor, Sigma2 receptor, Transmembrane protein 97.
What is the protein family that this protein belongs to?
Belongs to the TMEM97/sigma-2 receptor family.
What are the subcellular locations of this protein?
Nucleus membrane; Multi-pass membrane protein. Rough endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated.
Protein: RS3_BAUCH
Sequence: MGQKVHPNGFRLGIIKYWNSTWYANKKEFAQYLNSDFKVRQFLASELTKASISRVVIERPAKSIRITIHTARPGIIIGKKGEDVEKLRKSISLIAGVPSQINIAEVRKPELNAKLVAESIVSQIERRVIFRRAMKRAVQNTIRLGAKGIKVEVSGRLSGVEIARTEWYREGRVPLHTLRADIDYHVSEAHTTYGVIGVKVWIFKGEILDGMMAVEPTIESITPPKTQQRKGRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PI5K5_ARATH
Sequence: MSKDQSYVLKAWEVTVRKTQQAKKRANSVFGTVSVAPHTDNDTTTDDNDDETTTNRSSLEEFYHAERVLPNGDYYTGQWYDSFPHGHGKYLWTDGCMYIGDWYNGKTMGNGKFGWPSGATYEGEFKSGYMDGIGTYTGPSGDAYKGQWVMNLKHGHGVKSFANGDAYDGEWRRGLQEGQGKYQWSDGSYYIGEWKNGTICGKGSFVWTNGNRYDGFWDEGFPRGNGTFKWDNGSFYVGHWSKDPEEMNGTYYPSGNEGNLEWDPKDLFNNLSEYTICSGERVPTLPSQKKLSVWNSSKRIEKPRRTSVDGRVSVGVDRAFEKMNMWGNEIGEGGADMRKELDAELMRLDAEGLQSLKSSPVPMKLPKAGRKQGETISKGHRNYELMLNLQLGIRHSVGRQAPAASLDLKPSAFDPKDKIWRRFPREGTKYTPPHQSTEFKWKDYCPLVFRSLRKLFKVDPADYMLSICGNDALRELSSPGKSGSFFYLTNDDRYMIKTMKKSETKVLLGMLAAYYNHVRAFENSLVIRFFGLHCVKLNGPTQKKVRFVIMGNLFCSKYSVHRRFDLKGSSLGRTTDKPESEIDSNTILKDLDLNFIFRLQKAWYQEFIRQIDKDCEFLEQERIMDYSLLVGIHFREASVAGELIPSGARTPIGESEEESGPRLSRAEVDELLSDPSRWASIRLGTNMPARAERTMRKNDSELQLVGEPTGEFYEVVMIFGIIDILQDYDISKKLEHAYKSIQYDPSSISAVDPRQYSRRFRDFIFKVFTDDN
What are the official names of this protein?
Phosphatidylinositol 4-phosphate 5-kinase 5, AtPIP5K5, 1-phosphatidylinositol 4-phosphate kinase 5, Diphosphoinositide kinase 5, PtdIns(4)P-5-kinase 5.
Protein: CDA_MYROD
Sequence: MNFKSTVITAMCCFFSFAVLASEKLEKPKLVVGLVVDQMRWDYLYRYYDRYSENGFKRLLNEGFSSENTLIDYVPTYTAIGHSTIYTGSVPAINGIAGNDFIIQATGQNMYCTQDDSVQAVGGEGKVGQQSPKNLLVSTITDQLKLATNFQSKVIGIAIKDRGGILPAGHFANAAYWLDGKTGDWITSTYYMKDLPKWVKGFNKEKVVDQYYKQGWKTLYPIDTYVLSTADDNLYEETFKGEKTPTFPRDLVKLKKENGYELIKSTPQGNTLTLDFAKRAIENEQLGNNPLQVTDFLAVSLSSTDYIGHQFAINSIEIEDTYLRLDRDIADFLAYLDQNIGKGNYTLFLSADHGAAHNPKFFADQKGNSGYFDTKAIRKDLNEKLASKFGVADLVKSLANYQVHLNYEVIEANDVEEDEVIAAAIKLLKKVDGVAFVVDMNEAAESSVPQILRERIINGYNFKRSGAIQLILEPQWFSGSKDGKGTTHGSWNSYDAHIPAVFLGWGVKPGKTTRQTHMTDIAPTIAQILKIEFPNGNIGTPIQEAIEQ
What is the function of this protein?
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.  Has some hydrolysis activity also with dATP, GTP, UTP, ITP and 4-nitrophenyl phosphate as substrate.  No activity with ADP, CTP, acetyl dihydrogen phosphate or AMP-PNP as substrate.
What are the official names of this protein?
Calcium-transporting ATPase, Ca(2+)-ATPase, Calcium pump, Calcium-dependent ATPase.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Periplasmic side.
Protein: PAL1_CAEEL
Sequence: MSVDVKSDFSENESSSTPSPTTVPADVTWPHYPMMPFMQPHPLREKMLQPTFDPQIYGRWSQMGDTGFYGHPDLYPFGLPQLAANGQIPAVEAVDVKPPLSNGSSSSDSGMYPSPSDMMTPFPSTSSGAASSSELSAAAAAAANYQMRAATCYQQSVWPFMDYQQFQGFSWKMPLGNNHGKDRRSSSDGKTLPTGPGTNNVRVRTADKYRMVYSDYQRLELEKEFHTSPFITSDRKSQLSTMLSLTERQIKIWFQNRRAKDRRDKQKIRL
What is the function of this protein?
Transcriptional activator.  Interacts with promoter regions for tbx-8. 9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes.  Binds the sequence ATTTATGAC.  Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development.  Activates the gene for mab-5 in embryo development.  Necessary for vab-7 expression in C blastomeres in the posterior of embryos.  Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development.  Binds to ced-3 promoter and activated expression which is crucial for tail-spike cell death.  Has a role in E cell specification in endoderm development and body wall muscle development.
What are the official names of this protein?
Homeobox protein pal-1, Caudal homolog 1, Homeobox protein ceh-3, Posterior alae in males protein 1.
What is the protein family that this protein belongs to?
Belongs to the Caudal homeobox family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome. Note=Localized to condensed chromosomes.
Protein: PDXH_BRUA2
Sequence: MEPVKMTNSSDDFTQSAEPFKLFAEWLADAAKSEPNDPNAVALATVDPDGLPNVRMVLLKDFDETGFVFYTNYESKKGQEILSAEKAAMCFHWKSLRRQVRVRGPVEKVSDAEADAYYASRPRGSRIGAWASKQSRPLESRFALEKAVAEYTAKYAIGDIPRPPYWSGFRIRPVSIEFWHDRPFRLHDRVLFTRPTPEGDWNKDRLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: RNPA_XANCP
Sequence: MNASNPCRRFPRSARVRTRAQYTVVFDTARRTSDPLLSLHWRSGETPPRLGMAVSRKVDTRAVGRNRIKRVLRDAMRHLLPELAGGDYVIVARSAAAKATNPQIRDAFVRLLRRAGALPLPAAPGTMPPARAPRPSSLSPTEPDPRSD
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: PDXJ_BORPA
Sequence: MIELGVNIDHVATLRQQRHTAYPDPVQAALRAEDAGADLITLHLREDRRHIQDADVYAIRPLLRTRMNLECAVTPEMLEIACAVKPSDVCLVPEKRTELTTEGGLDVAGAQAAVTDAVQLLAEAGIRVSLFIDPDARQIEAAARAGAPVIELHTGAYAEARDDAAVQAELARVRAAVAEGLRHGLRVNAGHGLHYGNVQAVAALDGIAELNIGHAIVAQSIFDGWDKAVRDMKALMVQARLAAVRGHA
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIMP1_RAT
Sequence: MAPFASLASGILLLLSLIASSKACSCAPTHPQTAFCNSDLVIRAKFMGSPEIIETTLYQRYEIKMTKMLKGFDAVGNATGFRFAYTPAMESLCGYVHKSQNRSEEFLIAGRLRNGNLHITACSFLVPWHNLSPAQQKAFVKTYSAGCGVCTVFPCSAIPCKLESDSHCLWTDQILMGSEKGYQSDHFACLPRNPDLCTWQYLGVSMTRSLPLAKAEA
What is the function of this protein?
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor.  Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16.  Does not act on MMP14.  Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1.  Plays a role in integrin signaling.  Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
What are the official names of this protein?
Metalloproteinase inhibitor 1, Tissue inhibitor of metalloproteinases 1, TIMP-1.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I35 (TIMP) family.
What are the subcellular locations of this protein?
Secreted.
Protein: PIP_SYMSY
Sequence: MRLLQLLFRASPATLLLVLCLQLGANKAQDNTRKIIIKDFDIPKSVRPNEEVTATLAVQTELKECMVVKTYLISSVPLEGGFNYKYTACLCNENPKTFYWDFYTNRTVRIAAVVDVIRELGICPDDAAVIPIKNNRFYTIETLEVE
What are the official names of this protein?
Prolactin-inducible protein homolog, Prolactin-induced protein.
What is the protein family that this protein belongs to?
Belongs to the PIP family.
What are the subcellular locations of this protein?
Secreted.
Protein: RH10_ARATH
Sequence: MEEENEVVKTFAELGVREELVKACERLGWKNPSKIQAEALPFALEGKDVIGLAQTGSGKTGAFAIPILQALLEYVYDSEPKKGRRPDPAFFACVLSPTRELAIQIAEQFEALGADISLRCAVLVGGIDRMQQTIALGKRPHVIVATPGRLWDHMSDTKGFSLKSLKYLVLDEADRLLNEDFEKSLNQILEEIPLERKTFLFSATMTKKVRKLQRACLRNPVKIEAASKYSTVDTLKQQYRFVAAKYKDCYLVYILSEMPESTSMIFTRTCDGTRFLALVLRSLGFRAIPISGQMTQSKRLGALNKFKAGECNILVCTDVASRGLDIPSVDVVINYDIPTNSKDYIHRVGRTARAGRSGVGISLVNQYELEWYIQIEKLIGKKLPEYPAEEDEVLSLLERVAEAKKLSAMNMKESGGRKRRGEDDEESERFLGGNKDRGNKERGGNKDKKSSKKFKR
What is the function of this protein?
Involved in leaf polarity establishment by functioning cooperatively with AS2 to repress abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial development in leaf primordia at shoot apical meristems at high temperatures.  Involved in the processing of pre-rRNA intermediates at high temperatures.
What are the official names of this protein?
DEAD-box ATP-dependent RNA helicase 10, Protein ENHANCER OF ASYMMETRIC LEAVES TWO.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: RUTA_PSE14
Sequence: MDIGIFIPIGNNGWLISSNAPQYMPTFELNKQIVQTAEGYGFDFALSMIKLRGFGGKTEFWEHNLESFTLMAGLAAVTSKIQLFATVATLTIPPAIAARMASTIDSISNGRFGINLVTGWQKPEYEQMGLWPGDEFFHTRYEYLAEYAQVLRDLWATGSSDFKGEHFSMQDCRVSPRPKADMKLICAGQSEAGMAFSAQYADYNFCFGKGVNTPTAFAPTAQKLIEANEKTGRNVTSCVLFMIIADDTDEAARARWEHIKDGADEEAIAWLSEKGSADKSAGSNLRQMADPTSAVNINMGTLVGSWATVARMLDEVASVPGTQGVMLTFDDFVKGVEDFGEKIQPLMTSRKHIAQLKEVV
What is the function of this protein?
Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism, adding oxygen atoms in the process to yield ureidoacrylate peracid, that immediately reacts with FMN forming ureidoacrylate and FMN-N(5)-oxide.  The FMN-N(5)-oxide reacts spontaneously with NADH to produce FMN.  Requires the flavin reductase RutF to regenerate FMN in vivo.
What are the official names of this protein?
Pyrimidine monooxygenase RutA.
What is the protein family that this protein belongs to?
Belongs to the NtaA/SnaA/DszA monooxygenase family. RutA subfamily.
Protein: BCL10_MOUSE
Sequence: MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPRGLDTLVESIRREKTQSFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRCNSDESNLSEKQRASTVMYHPEGESSTAPFFSMASSLNLPVLEVGRTENSSFSSATLPRPGDPGAPPLPPDLRLEEGGSCGNSSEMFLPLRSRALSRQ
What is the function of this protein?
Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PubMed:22265677).  Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:22265677).  Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (By similarity).  This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity).  Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PubMed:22265677).  Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (By similarity).  Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (By similarity).
What are the official names of this protein?
B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, mCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, mCIPER, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, c-E10, Mammalian CARD-containing adapter molecule E10, mE10.
What are the subcellular locations of this protein?
Cytoplasm. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Protein: PUR2_MYCTU
Sequence: MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQHDVDITSAEAVVALAREVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPGKDAARIEGSKAFAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPAGDPAWVVKDDRLAAGKGVVVTADRDVARAHGAALLEAGHPVLLESYLDGPEVSLFCVVDRTVVVPLLPAQDFKRVGEDDTGLNTGGMGAYAPLPWLPDNIYREVVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVVEFNCRFGDPETQAVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRPRVGDVVVGSEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAHAYEILSSIRLPGGHFRSDIGLRAAEGKISV
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: IAPP_FELCA
Sequence: MCLLKLPVVLIVLLVALHHLKATPIESNQVEKRKCNTATCATQRLANFLIRSSNNLGAILSPTNVGSNTYGKRSTVDILNREPLNYLPF
What is the function of this protein?
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
What are the official names of this protein?
Islet amyloid polypeptide, Amylin.
What is the protein family that this protein belongs to?
Belongs to the calcitonin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS5_FRATW
Sequence: MSNEVKKNEELIEKLVSVKRHSKTVKGGRIMSFAALTVVGDGKGRIGVGRGKSREVPAAIQKAMENAKKNMVSVNLNNDTLWYPVMSNHGASKVFMQPASAGTGIIAGGAMRSVFEAVGVHNVLAKTYGSTNPANVVRATIAGLAKIKSPDEIAEKRGLSVEEIQG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: COBD_SYNY3
Sequence: MMAVDPNLFPLIAVIILGGSALLDFLLGDPKSWRHPVEFIGSVINFASQLIIRKVNDKNSRRLWGIFLGLKIIISSGFLAWLIVYLAEKVSPVLAVIIQIIGVASCFAGHSLAQAAQSVIEPLKAGDLPTARQKLALFVGRDTNNLSEREILRATVESVAENTVDGVTSPLFYALLGILFPFVGPWPLAIAYKAASTLDSMVGYKREPYTDLGWFSARLEDYLTWLPCRLTVFMLAILSGKPKQTWAIVRRDGPLDPSPNSGWSEAIYAAILGIQLGGDNYYQGVLKSKPLLGDGIQPLTIAKIAQSLWYSRTVFLWQLLLGLTVILAIQAGAMSEISFNKI
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GDL33_ARATH
Sequence: MGLPSSLESYLLLILLSFLNVSTIYSSKPSKEEAVLFGGNFPAFYVIGDSLVDPGNNNHLPTMIRANYPPYGSDFEGGKATGRFSNGKTIADYIAIYYKLPLVPAYLGLSDDRKDTISTGMNYASAGCGIRRLTGKIAGKCLSLSKQVDLFEETIEKHLKTNFKTPYELREHLAHSLFMTVIGVNDYAFFYTRLTDANDFADELLHKFLKKIEKLHKLGARKFFINNIKPLGCYPNIVAKTFMLGLRGPSTNRYSSNLLNTTGPCCPLDYDGSLTSSCKRRSKTCKAPDSTHIFFDPRHPTQLANFMYSIACFDERTICHVV
What are the official names of this protein?
GDSL esterase/lipase At2g04020, Extracellular lipase At2g04020.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
What are the subcellular locations of this protein?
Secreted.
Protein: TAT_HV1M2
Sequence: MEVVDPNLDPWKHPGSQPETPCNKCYCKKCCFHCQLCFTRKGLGISYGRKKRRQRRRTPQSGEVHQDPVSKQPLSQTRGDPKGPEESKKKVESKTKTDPSD
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type.
Protein: RL32_ENCCU
Sequence: MSSELFDPKPLVEIKEAYRKNKKFIRHHSDRYKRVKPSWRRPHGIDSKVRKRCKGEREMPSIKYKKPKEIRHLLPNGLRKVRIFNINDLTPLTSLNRFYCGEIAHAVGARKRIAIVNRAKELGICLLNGNARLIPEIEE
What are the official names of this protein?
60S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
Protein: LGT_SHIFL
Sequence: MTSSYLHFPEFDPVIFSIGPVALHWYGLMYLVGFIFAMWLATRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPQFMADPLYLFRVWDGGMSFHGGLIGVIVVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPNFPFAMLFPGSRTEDILLLQTNPQWQSIFDTYGVLPRHPSQLYELLLEGVVLFIILNLYIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIVAGVIMMVWAYRRSPQQHVS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.