PharMolix/UniProtQA huggingface dataset:
Protein: SWS_DROYA
Sequence: MDVLEMLRASASGSYNTIFSDAWCQYVSKQITATMYMYCAFGLMGVLFLAWFMYFKRLARLRLRDELARSISSVTNSYGDLRGLRFRKRDKMLFYGRRMLRKMKNVSGQMYSSGKGYKRRAVMRFARRILQLRRDNMPLEMRTVEPPAEYLEETIEGSDRVPPDALYMLQSIRIFGHFEKPIFLRLCKHTQLLELMAGDYLFKITDPDDSVYIVQSGMINVYISNADGSTLSLKTVRKGESVTSLLSFIDVLSGNPSYYKTVTAKAIEKSVVIRLPMQAFEEVFQDNPDVMIRVIQVIMIRLQRVLFTALRNYLGLNAELVQNHMRYKSVSTMSGPINSQTSQSSRQATANGPPMVINQLNLMQSAASGLGMGMGTGTGSGVSVTVTRPPPSPSRHSREEHTLSDPNPNPDGSVHGTSNLFTEVHGDAPNADLFHQQQQSVGNLSTRRSSITQMTPDGSHTCPQAPGVTTSIDMRLVQSSAVDSLRKELGLSEEDAHIIEPFVELRELEPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKNDMLIHFVHPGEIVGGLAMLTGEASAYTIRSRSNSRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVRQCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEIVGEYGKGDLVGIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTRSGSGAPGAPVEANPVTHKYSTVALVPITDEVPLTPFTYELYHSLCAIGPVLRLTSDVVRKQLGPNIFEAANEYRLTSWLAQQEDRNIITLYQCDSSLSAWTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLYPEATNAKPANTLSWLNARPWVTKHHHVLCVKRIFTRKSQYRINDLYSRVLLSEPNMHSDFSRLARWLTGNSIGLVLGGGGARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKWFLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSLWRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPGHLWRYCRASMSIAGVFPPFCDYRDGHLLLDGCYTNNVPADVMHNLGAAHIIAIDVGSQDDTDLTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRPPIDKYKTLAFGSFDEIRDVGYVFGKNYFENMAKAGRLGRFNQWFNKEPPKRVNHASLNEYTFIDLAQIVCRLPETYAVNTAELFSEDEDCDGYISEPTTLNTDRRRIQVPRAGNSLSFSETEMDSDVELDLKLERKMDKSTQSTPPTSSRASVRGKEEARHMDNWHWSVKHKVETASGATEATNAMIDQEQQHQQQADQGVGAEQLADKDEDKENRSSTYNETKN
What is the function of this protein?
Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho).  This deacylation occurs at both sn-2 and sn-1 positions of PtdCho.  Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.  Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain.  Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).
What are the official names of this protein?
Neuropathy target esterase sws, Swiss cheese.
What is the protein family that this protein belongs to?
Belongs to the NTE family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Sws tethers Pka-C3 to the membrane.
Protein: CBD1_CAEEL
Sequence: MGPQLATVSLLLLTFFSNSIQYPHSPAATECPAYFNGNIAGNACSREYSICVNGVRQAATCSDDSVFYEDECVPVDESPECRVDENTEEDDTPYAEFDCTSKQDGIYSIGCSNQFISCVAGGAYMAKCPDSLVFNERTQDCRESCDEVKQDTTTAPQVYEDGEEGYGEASGEIAGDYERQPSNEQPDSIDFDCNGLEDGNYADGCNDVFYSCSNNMVFQRYCPPGTVFNINQQSCDFQCTTDDPTTTVSYSTSTITTPQEDDSEYSSTTSADVISTTTTPSIDAIETTTTGFDAVTTTTTTQTPFVCQEGQVNSFGMCSSRFNRCQNNSVRSKQCPVNTLFESSLVMCVFDLPQCQPITVPAAPAYNSYGPPSDTIVSPFDENVRLKPKFDRRRKYHHGKPSYGPVNGNSYLENPFFIPRHRGGSHRDHRRYGYGPAIDSPFSTAFRGRAALSDQFKDYRRARMGKIQGDARKVDGNKRFLIDDEFEGPNAKFVESNIEQVFPKNRHSKKQLGPHEDPDGYDDEKTFDAKDLFGATRRKRSAYYGTEQSVYGQQSAQISARQAQVNKDCQQYTTPTFLTFGDCFDQFIFCSGNGINRMAACPIGETFDKTLRSCSETCGVSTTIVAVTIGTQTSDDLSAPSEYIENDGVTTQSTWNDQPSTTQAPNSYESYTTQYSSNDVPSTSAAPIGDRCSLDASGLFSLGCSQKYIQCSNGAAIVRRCGESLYFNEATQECTYRDEVPECGSQGSTSSPVITTPGQDQSSNYYGIPSDDVPSTTQTPVGDRCAYVASGLFDLGCSQKYIQCSDSAASVRECEGSLYFDERSQSCRFRDEVFKCQTADVSSSSTVPYLDFTTTPASPSEDEPTTYEPSVAPYIPSVTVNPVDTCTSLSDGTHGTGCSSFYFVCSHGRLISSGNCQLGEGYDPSVQGCRTFSEIPARACDEQEVTTDAGLVQLMPYKTLEEVLTTTEAATTVANDGPTDTYITGSTKYSTTDSGEYTIPYGDETTSTRSYDRADNDSEDEEEDDVEHDQKCTVGSRTPVGFCVRTYLECTDAGNVEKLCRIGKLFDSHSNRCVPRIGCGKEAIRDAIKDMIATTPAPAQPKQFEGRCAHVDGEAVFSIGVCSSKYLRCSYGASKLQQCSEDRVFSNDKLECIVRESVSACTVPKNPSIKKYYTSNDQSAFCDGKEDGLYRNERDCSAILQCFGGELFEHPSCQSSLAFNQLTGKCDYPQKVSGCENHGQTNGECSEHGSFIADANNCEVFYRCVWGRKVVMTCPSGTVFNPLLSVCDWPSAVPSCSGQASDSNSSYGSSTYNDDKSGY
What is the function of this protein?
In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2.  Essential for the formation of a continuous and cohesive chitin layer following fertilization.
What are the official names of this protein?
Chitin-binding domain protein cbd-1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Note=Localizes around oocytes in the proximal region of the germline.
Protein: RECF_COXBN
Sequence: MPYIGSLKVNQFRNLADVDITPHSQFNFFFGQNGAGKTSILESIYYLSVGRSFRTHLPQRLIQDNTDRFLIFITLYNGTQFIPLGVERDCHGDRCLRINGETASSWSLAAKRLPLCSLSAMSHRFLLDGPRVRRQFLDWLMFHVEPSFFSIWQRLQRSLKQRNAALKAKLPLGEITHWDKMLVEDGERLHQLRQNVVTEFRPLFTQMLQQFLPAYPLIGHYFRGWSEKYSLMEQLQINLKQDLQRGYTQAGPQRADFRLTLRDLPAQDILSQGQQKLVTYALHFAQGLLLKEKTGISPIYLIDDLPAELDANKRDCVIDLVNYLESQVFISGIDPNEIRLPPHSTLFHVKHGKVAAL
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SURE_THET8
Sequence: MRILVTNDDGIYSPGLWALAEAASQFGEVFVAAPDTEQSAAGHAITIAHPVRAYPHPSPLHAPHFPAYRVRGTPADCVALGLHLFGPVDLVLSGVNLGSNLGHEIWHSGTVAAAKQGYLFGLSAAAFSVPLNGEVPDFAGLRPWLLRTLETLLRLERPFLVNVNLPLRPKGFLWTRQSVRAYEGVVIPGEDPMGRPFYWFAPRPLKEAEEGTDRWAVAQGFVSATPLRLDLTDETRLQPTLAHD
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_STRPF
Sequence: MSDSHLTAFDKASKAGFIIALGIVYGDIGTSPLYTMQSLVENQGGVNQVSESFILGSISLIIWTLTLITTIKYVLIALKADNHHEGGIFSLFTLVRKMSPWLIIPAMIGGATLLSDGALTPAVTVTSAIEGLKAVPGLSHIYQNQTNIIITTLVILIVLFGIQRFGTGFIGKIFGPVMFIWFSFLGVSGFFNTLGHLEIFKAINPYYALHLLFSPENHRGIFILGSIFLATTGAEALYSDLGHVGRGNIYVSWPFVKMCIVWSYCGQAAWILANKHSGIELNPFFASVPSQLRVYLVSLATLAAIIASQALISGSFTLVSEAMRLKIFPLFRVTYPGANLGQLYIPVINWILFAVTSCTVLAFRTSAHMEAAYGLAITITMLMTTILLKYYLIKKGTRPILAHLAMAFFALVEFIFFLASAIKFMHGGYAVVILALAIVFVMFIWHAGTRIVFKYVKSLNLNDYKEQIKQLRDDVCFDLYQTNVVYLSNRMQDHMIDRSILYSILDKRPKRAQVYWFVNVQVTDEPYTAKYKVDMMGTDYMVRVNLYLGFRMPQTVPRYLRTIVQDLMESGRLPKQEQEYTITPGRDVGDFRFVLIEERVSNARQLSNFERFIMQTKASIKHVTASPMRWFGLQYSEVTLEVVPLILSDVLKLPIKELVPVEDSEA
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PPK5_BLEDI
Sequence: SGETSGEGNGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, BleDi-Capa-PK, FXPRL-amide.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARC1_SCHPO
Sequence: MSFLWAKEFCVLKYPYKLFITHKFSYLLRFETVTLNNIRSPQFYAKLTFSHHQPTVSGTMSTELKFISKYLQISIPETKEGPVSSLFKAVSEQKPELLGNTDFEKAQILEWTTKAFSPIETQSIVEQLDEFLKSSTFIAQDSGISVADLAVYARIHSYICGLSAKEGYKLNNVCRWFDFIQHQESVMEAANSMSMKLANIDLNAPKIQRPSVIKKDKKEKKEGKPSQEASVKSVEKAPKGLEGAKKEKQNKKEKKDKKDKKDKKEKAPKEPPKAATPVPSMIDFRIGFIEKAVKHPNADSLYVSTIHCGDAEGPRTVCSGLVKYIPLEQMQQRKVIVVANLKPVNMRSVKSQAMVFCASSPDKSVVEFVLPPENAEIGDRLTFEGFDTEEPEAQLNPKRKIWEAIQPGFTSGEDLICGYKDESGLHRLFVKGKKDLGFCKAQTVVNGTLS
What is the function of this protein?
Binds to tRNA and functions as a cofactor for the methionyl-tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRS).  Forms a complex with MetRS and GluRS and increases their affinity for cognate tRNAs due to the presence of a tRNA binding domain in its middle and C-terminal part (By similarity).
What are the official names of this protein?
tRNA-aminoacylation cofactor arc1.
What is the protein family that this protein belongs to?
Belongs to the tRNA-aminoacylation cofactor ARC1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMG_MESM1
Sequence: MAAKIYDAIVIGGGHAGVEAAFILSKKNFNVALISLNQNRLASMPCNPSIGGPAKGIITREIDALGGKQAYFADQAMIQIKMLNTSKGPAVRAIRAQIDKEKYSQIILKAVQETKNIDLIEDMVFEIQTKDNKISGVITEKNGLLETKTAIITAGTYLDSYILRGEEKYSSGPDGEKTSNSLSNSLIKLGFKLLRLKTGTPPRIYANSIDFSEVEEEILPESNLNFSIYHSKKLSKQIHCYLTYTSEKTHQIILDNINKSSMYSGLIKGIGPRYCPSVEDKIVRFKDKERHQIFFEPETIKADIMYINGLSTSMPIDVQDQMIKSINGLKNAKVAKYAYAIEYDAIDPLQLKKSLESKEIENLFFAGQINGTSGYEEAAGQGLLAGINASLKLENREALNLKRSDSYIGVLIDDLTTKGTKEPYRMLTSRAEYRLLLRNDNADIRLLKYAKYAKTLTDKEIATTEAKYDLITKKIAELENQYISINDPLAKKYNLANSTSFLQLISRHEIDIKEIVGNFPFLEELSTNVRLDGYIKKQLSQADKMLRLENLKLPEDLNYDNVVNLAFEARQKLKMIKPLTIGQASRISGINPADIQMLMFHLNLKVVKNEN
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
Protein: SYC_YERPG
Sequence: MLKIFNTLSRQKEEFKPIHAGKVGMYVCGITIYDLCHIGHGRTFVAFDVVARYLRYLGYSLTYVRNVTDVDDKIIKRAIENNETCEQLTTRMLAEMHKDFDALNLERPDLEPRATHHIAEIIEMTERLIARGHAYVASNGDVMFAVDSDPDYGVLSRQDLDQLQAGARVEVADVKRNPMDFVLWKMSKPGEPRWESPWGPGRPGWHIECSAMNGKQLGAHFDIHGGGSDLMFPHHENEIAQSTCAHDGPYVNYWMHSGMVMIDKEKMSKSLNNFFTIRDVLAYYDAETVRYFLMSGHYRSQLNYSEENLKQARASLERLYTALRGTDANATPAGGAEFEARFRTAMDDDFNTPEAYSVLFDIAREVNRLKNEDMAAANGLAAELRKLAQVLGLLEQDPELFLQGGAQADDDEVAKIEALIKQRNDARSSKNWALADAARDQLNELGIVLEDGPQGTTWRRK
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDRGK_DROVI
Sequence: MDLILLVGIATALLLILITLYFLQSKNAKTETKAAAQPQRGVPQRAQEGVPRRAQIARNQRNRLRQNQNAPAVAAAAAPAAAVDSDDDEAAAAGDENGPRVPQGAVLDEKMGAKKRAKMEAKEQKRLQREQELHDREQRKVKEAKEDAERKQQEDLDAEVERKKAEADRLAKEERERKEHEEYLKMKAAFSIEEEGFEEGDADDKESLLADFIQYIKDNKVVLLEDLATAFKLKTQQAIDRIQELQENGTLTGVIDDRGKFIYVSEAELAAVAKFIKQRGRVSIAELAESSNNLINLTPVAAGESSA
What is the function of this protein?
Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins.
What are the official names of this protein?
DDRGK domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the DDRGK1 family.
Protein: Y1210_PSEAE
Sequence: MIERRPFDRLGHANHGWLNARHHFSFADYYDPEREDWGRLRVWNDDEIAAGSGFPPHPHRDMEIITYVREGAITHQDSLGNKGRTEAGDVQVMSAGTGIVHSEYNLEAETTRIFQIWIIPDRRGDQPRWGSKPFPKAERDGRFVTLASGDEQDSEALHIRADAEVAAVTLKAGQSAEYALENGRRAYLVPATGSIEVNGVRAEARDGLAVRDEPTLKVTALEDSEVLLVEVA
What is the function of this protein?
Putative quercetin 2,3-dioxygenase.
What are the official names of this protein?
Putative quercetin 2,3-dioxygenase PA1210, Putative quercetinase, Pirin-like protein PA1210.
What is the protein family that this protein belongs to?
Belongs to the pirin family.
Protein: LT_POVHA
Sequence: MDRILTKEEKQALISLLDLEPQYWGDYGRMQKCYKKKCLQLHPDKGGNEELMQQLNTLWTKLKDGLYRVRLLLGPSQDPNASTSTSRPGEFYNPDTGGYWSYSYGSAGYSDQQKKYWEEFFSKWDVNEDLTCQEELSSSEDEFTPWHPNPPPSPVSISSDSSSSSCDEEYPRNSSRKRKRVHANGSPNTPIQPNKRAHTPGGGRTTIRGDTDIPRTPARESQSTFGSYFNSTEELEEEISQTQQSHHNTTPKKPPPTVSPDDFPTILRGFLSHAIFSNKTQNAFIIYSTKEKCEVLYEQIDKYNPDYKGIFIMKQTEAFVMFMTPGKHRVAAVKSYCCKFCTVSFLLCKAVTKPLELYNCVAKCDDFQILKENKPGLYHFEFCDEKKEVKQIDWNFLTSFAVENELDDPLVIMGHYLEFSQCESSCKKCAEALPRMKVHWANHSQHLENAELFLHCKQQKSICQQAADNVLARRRLKVLESTRQELLAERLNKLLDQLKDLSPVDKHLYLAGVAWYQCMFPDFEMMLLDILKLFTENVPKKRNVLFRGPVNSGKTSLAAAIMNLVGGVALNVNCPADKLNFELGVAIDKFAVVFEDVKGQTGDKRHLQSGLGINNLDNLRDYLDGSVKVNLEKKHVNKRSQIFPPCIVTANEYFFPQTLYARFHKVYNFEVKDFLAKSLEENSYMGRHRVCQSPLTMLIALLWNVPTENFDKSLKEKVETEKKVLSDMCNFTTFAEMCLNIQRGADPLEAL
What is the function of this protein?
Isoform large T antigen is a key early protein essential for both driving viral replication and inducing cellular transformation.  Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle and by autoregulating the synthesis of viral early mRNA.  Displays highly oncogenic activities by corrupting the host cellular checkpoint mechanisms that guard cell division and the transcription, replication, and repair of DNA.  Participates in the modulation of cellular gene expression preceeding viral DNA replication.  This step involves binding to host key cell cycle regulators retinoblastoma protein RB1/pRb and TP53.  Induces the disassembly of host E2F1 transcription factors from RB1, thus promoting transcriptional activation of E2F1-regulated S-phase genes.  Inhibits host TP53 binding to DNA, abrogating the ability of TP53 to stimulate gene expression.  Plays the role of a TFIID-associated factor (TAF) in transcription initiation for all three RNA polymerases, by stabilizing the TBP-TFIIA complex on promoters.  Initiates viral DNA replication and unwinding via interactions with the viral origin of replication.  Binds two adjacent sites in the SV40 origin.  The replication fork movement is facilitated by Large T antigen helicase activity.  Activates the transcription of viral late mRNA, through host TBP and TFIIA stabilization.  Interferes with histone deacetylation mediated by HDAC1, leading to activation of transcription (By similarity).
What are the official names of this protein?
Large T antigen, LT, LT-AG.
What are the subcellular locations of this protein?
Host nucleus.
Protein: KTHY_AFIC5
Sequence: MAKRATRARPGRGRFITFEGGEGSGKSTQIQLLAERLKGQGIETLVTREPGGSPGAEIVRHLLLSGVGKLLGADAETLLFAAARDDHVHQVIEPALKKGVWVLCDRFTDSTAAYQGAAGKVDAAFIEALTHATIGDLEPDLTLILDVPVAVGLHRAIKRRGKAVADRFEQESLSFHESLRDAYRKIAADNPKRCAVVDANADAATVSERIWETMQHRLASALPARARA
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: NOE1_RAT
Sequence: MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTRLSAASGGTLDRSTGVLPTNPEESWQVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVEKMENQMKGLESKFRQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQFKEEVQNLTSVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTVKTSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMVDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVDENGLWAVYATNQNAGNIVISKLDPVSLQILQTWNTSYPKRSAGEAFIICGTLYVTNGYSGGTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQTLYNVTLFHVIRSDEL
What is the function of this protein?
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1.  Inhibits RTN4R-mediated axon growth cone collapse (By similarity).  May play an important role in regulating the production of neural crest cells by the neural tube (By similarity).  May be required for normal responses to olfactory stimuli (By similarity).
What are the official names of this protein?
Noelin, 1B426B, Neuronal olfactomedin-related ER localized protein, Olfactomedin-1, Pancortin.
What are the subcellular locations of this protein?
Secreted. Synapse. Endoplasmic reticulum. Cell projection, axon. Perikaryon.
Protein: DEF1_SORBI
Sequence: RVCMGKSQHHSFPCISDRLCSNECVKEEGGWTAGYCHLRYCRCQKAC
What are the official names of this protein?
Defensin-like protein 1, Small protein inhibitor of insect alpha-amylases 1, SI alpha-1.
What is the protein family that this protein belongs to?
Belongs to the DEFL family. Protease inhibitor I18 (RTI/MTI-2) subfamily.
Protein: SF3B4_MOUSE
Sequence: MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAGGHGPPAAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ
What is the function of this protein?
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex.  SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.  Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA.  May also be involved in the assembly of the 'E' complex.  SF3B4 has been found in complex 'B' and 'C' as well.  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
What are the official names of this protein?
Splicing factor 3B subunit 4.
What is the protein family that this protein belongs to?
Belongs to the SF3B4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SC5AB_RABIT
Sequence: MESSTSSPQPPLSDPLDPFPQRSLEPGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFVGLAGSGAATGISVAAYEFNGMFSVLMLAWIFLPIYIAGQVTTMPEYLRRRFGGSRIAITLAVLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLSVVGLLAVTALYTVAGGLAAVIYTDALQTLIMLVGALTLMGYSFAAVGGMEGLQEKYFLALPSNRSENSSCGLPREDAFHLFRDPLTSDLPWPGILFGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLMAAYLKVLPLFIMVFPGMVSRILFPDQVACADPETCQRVCNNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHVRPRASEKELMIVGRVFVLLLVLVSVLWIPVVQASQGGQLFVYIQAISSYLQPPVAMVFVLGCFWKRANEKGAFWGLVLGLLLGFIRLILDFIYVEPACHQPDERPSVVKNVHYLYFSMILSSVTVLTVTVMSLLTEPPSKEMISHLTWFTRRDPVVQKAQVPAATPLPPALSHNGTAEANSASIQLETIQEGASKAHSSDVTPKQSRVVRALLWLCGMEGKSTEQAPRPAEPVLASIEENPVVKTLLDVNCLLCICCAFFLWGYFA
What is the function of this protein?
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1.  Exclusively responsible for apical MI transport and absorption in intestine.  Can also transport D-chiro-inositol (DCI) but not L-fucose (PubMed:12133831, PubMed:15181167, PubMed:17932225, PubMed:15613375).  Exhibits stereospecific cotransport of both D-glucose and D-xylose (PubMed:12133831).  May induce apoptosis through the TNF-alpha, PDCD1 pathway (By similarity).  May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (PubMed:17306760).
What are the official names of this protein?
Sodium/myo-inositol cotransporter 2, Na(+)/myo-inositol cotransporter 2, Sodium-dependent glucose cotransporter, Sodium/glucose cotransporter KST1, rKST1, Sodium/myo-inositol transporter 2, SMIT2, Solute carrier family 5 member 11.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Note=Located on membrane of kidney brush border membrane vesicles (BBMVs) and apical membrane of proximal convoluted tubules.
Protein: SCIN_BOVIN
Sequence: MAQGLYHEEFARAGKRAGLQVWRIEKLELVPVPESAYGNFYVGDAYLVLHTTQASRGFTYRLHFWLGKECTQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESTDFVGYFKGGLKYKAGGVASGLNHVLTNDLTAQRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVAIGIRDNERKGRAQLIVVEEGSEPSELTKVLGEKPKLRDGEDDDDIKADITNRKMAKLYMVSDASGSMKVSLVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSTNTQIQVLPEGGETPIFKQFFKDWRDRDQSDGFGKVYVTEKVAHVKQIPFDASKLHSSPQMAAQHHVVDDGSGKVQIWRVENNGRVEIDRNSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKEGQAPAPPIRLFQVRRNLASITRIMEVDVDANSLNSNDVFVLKLRQNNGYIWIGKGSTQEEEKGAEYVASVLKCKTSTIQEGKEPEEFWNSLGGKKDYQTSPLLESQAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKSESLKSAKIYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW
What is the function of this protein?
Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane.  In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:1651929, PubMed:1847925, PubMed:8780652).  Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (PubMed:8780652).  Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity).  Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity).  Regulates chondrocyte proliferation and differentiation (By similarity).  Inhibits cell proliferation and tumorigenesis.  Signaling is mediated by MAPK, p38 and JNK pathways (By similarity).
What are the official names of this protein?
Scinderin, SC, Adseverin.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection, podosome.
Protein: RS17_NEIM0
Sequence: MSETKNVRTLQGKVVSDKMDKTVTVLVERKVKHPLYGKIIRLSTKIHAHDENNQYGIGDVVVISESRPLSKTKSWVVSELVEKARSI
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.