PharMolix/UniProtQA huggingface dataset:
Protein: CODY_BACAN
Sequence: MELLAKTRKLNALLQSAAGKPVNFREMSDTMCEVIEANVFVVSRRGKLLGYAIHQQIENERMKQMLAERQFPEEYTQSLFNITETSSNLDVNSAYTAFPVENKELFGQGLTTIVPIVGGGERLGTLVLARLGQEFLDDDLILAEYSSTVVGMEILREKAEEIEEEARSKAVVQMAISSLSYSELEAIEHIFEELNGTEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGTYIKVLNDKFLHELAKLKTN
What is the function of this protein?
In B. anthracis, CodY represses or activates directly or indirectly several hundred genes, including genes involved in amino acid biosynthesis and transport, as well as nucleic acid metabolism, the pentose pathway, the tricarboxylic acid cycle, acetyl coenzyme A synthesis and oxidative stress functions (PubMed:19651859, PubMed:23292769).  Among others, represses directly the expression of sap and eag, encoding the two surface layer (S-layer) proteins, by binding directly to their promoter region (PubMed:23292769).  Binds to a 11-bp non-palindromic consensus DNA motif, the CodY-binding site (PubMed:23292769).  Additionally, in pathogenic bacteria, CodY also regulates virulence gene expression and provides a regulatory link between metabolism and pathogenesis (PubMed:19651859, PubMed:21911592).  Is essential for the acquisition of iron from the host during infection (PubMed:21911592).  Interacts with the atxA global regulator promoter region, but it has only a small effect on atxA transcription, specifically during the exponential growth phase (PubMed:19651859, PubMed:23292769).  May regulate toxin gene expression by post-translationally regulating the accumulation of AtxA (PubMed:19651859).  Has no discernible effect on the regulation of capsule biosynthesis (PubMed:21911592).  Binds to GTP and exhibits weak GTPase activity (PubMed:28472295).
What are the official names of this protein?
Global transcriptional regulator CodY.
What is the protein family that this protein belongs to?
Belongs to the CodY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NAGC_SHIFL
Sequence: MTPGGQAQIGNVDLVKQLNSAAVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIVTETRNFHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGNVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDSLASEVIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILLQHLLEN
What is the function of this protein?
Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon.
What are the official names of this protein?
N-acetylglucosamine repressor.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family.
Protein: RSD_SALNS
Sequence: MLNQLENLTERVGGSNKLVDRWLDVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLLHAAKIWPLLEDNTQRIMDYYDTSLETAIDHDNCLEFQQALSDIGEALEARFVLEDKLIMLVFDAMHDGARVKRPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4_RHILW
Sequence: MSKRESSKYKIDRRMGENIWGRPKSPVNRREYGPGQHGQRRKGKLSDFGVQLRAKQKLKGYYGDLREKQFRAIFAEADRRKGDTSENLIGLLESRLDAIVYRAKFVPTVFAARQFVNHGHVTVNGVRVNIGSYRCKAGDVIEVREKSKQLVIVLEAVSLAERDVPDYIEVDHNKMVATFGRVPTLSDVPFPVVMEPHLVVEFYSR
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: RPOA_SORC5
Sequence: MTMNNPNLTMIARNWRDLIRPKGISIDAESGTQFYAKFTCEPLERGFGITIGNSLRRVLLSSLQGAAATAIRIEGALHEFTTVPDVVEDVSDIILNVKEVVFKAATPKTYSVRIDREGPGPVYARDIQLVEGLSVLNPDHLIAVLDKKGPLSMELTVNVGRGYVPAERNKTPTMPIGTIPIDALFSPIRKVNYTVQNARVGQVTDYDKLTLEVWTNGSVSPADAVAFAAKILKEQLSIWVNFEESEETSYQAVMSDDEPLNENLFRSVEELELSVRSANCLQNANITLIGELVQRTEQDMLKTKNFGRKSLKEIKEILANMGLSLGMKIDNWPQLLERWKAQQAQA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: AO2B_TOBAC
Sequence: MATGIASGCGQLHLRKPVYLRNSYGNKAHCHSNVILNGTQNQIAWSSWVSNVLRVNRSSYPECQVIKTNWKSSRGTIKSCQQRDGSVTRYFDFTVIGSGIAGLRYALEVAKHGTVAVITKAEPHESSTNYAQGGVSAVLCPLDSVESHMQDTIVAGAYLCDKETVRVVCTEGPERIRELIAMGASFDHGEDGNLDLAREGGHSHRRIVHAADMTGREIERALLEAVFKNPNIHVFQHHFAIDLLTTQDGSDIVCHGVDTIHTETKEVIRFISKVTLLASGGVGHIYPSTTNPTVATGDGMAMAHRAQAVISNMEFVQFHPTALADEGLPNIPSARENAFLITEAVRGDGGILYNLDMERFMPMYDERAELAPRDVVARSIDDQLKKRGEKYVLLDISHKPREKVLSHFPNIAAECLRHGLDITQQPIPVVPAAHYMCGGVRAGLEGETNVQGLYVAGEVACTGLHGANRLASNSLLEALVFARRAVQPSIDHVNVSRIDHGASSWWPRPVAPMVLGDTVLNKVICRTREVRKELQSIMWEYVGIVRSNSRLNTAEKRIRELELEWETYLFQHGWEPTMVGVEACEMRNLFCCANLVVSSALSRHESRGLHYTTDFPHVEESERLPTVIFPSQRNNSWSSRQLHAQPIS
What is the function of this protein?
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (PubMed:32242247).  Catalyzes the oxidation of L-aspartate to iminoaspartate (By similarity).
What are the official names of this protein?
L-aspartate oxidase 2-b, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AROA_ANADF
Sequence: MTGSLTCRRKGPLRGSIEVPGDKSISHRALLFGALSTGETRVRGLLDAEDVHATRRAVEALGATVRAEGEELVVVPPPALREPGDVVDCGNSGTSLRLLTGVLSGVPGLSILTGDASLRRRPVRRVIEPLRRMGADLSARDGDRLPPVVVRGRPLRGARHVLEVASAQVKSACLLAGLFAEGETTVVEPERSRDHTERMLAGMGVPVRVDGLEVTVAPARPRGGRVDVPGDISSAAFFLCAAAALPGSEVTVRNLGVNPTRTGLLDVLGAMGAALSRANEREVAGEPRADVTVRAAALHGTEIGGAIIPRLIDELPVVMVMATQARGRTVIRDAKELRVKESDRLASMGEALARAGAKIELFEDGCAIEGPTPLRGVAVQTRLDHRIAMSMAVAQLLAGGEEVVLDDVACVATSFPSFFALLDGLCEGGA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_DESVV
Sequence: MARITVEDCQKRIDNRFLLVQMAIKRVQQYREGYEPLVDSKNKEVVTALREIAAGKVMPEDLALYRPAEGEEMPVAE
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: KCC1B_MOUSE
Sequence: MLLLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQHLWISGDAAFDRDILGSVSEQIQKNFARTHWKRAFNATSFLRHIRKLGQSPEGEEASRQCMTRHSHPGLGTSQSPKW
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade.  In vitro phosphorylates CREB1 and SYN1/synapsin I.  Phosphorylates and activates CAMK1 (By similarity).
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type 1B, CaM kinase I beta, CaM kinase IB, CaM-KI beta, CaMKI-beta, Pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ENDA_PYRNV
Sequence: MSGVLRGLAVVVQDVELARALYREGFYGRFLGYDKVKRDEVDKVSAPLILALYEALYLAERGRIKVVAEDGAEIPPEKLAELGRGMIRNFDDVYKIYKYFRDLGYVVKSGLKFGALFSVYEKGPGIDHAPMVVVFLEPDRGISATDITRGGRLGHSVKKTFTLATVLRQTGEVVLLGFSWAKL
What is the function of this protein?
Endonuclease that removes tRNA introns.  Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron.  The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini.  Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
What are the official names of this protein?
tRNA-splicing endonuclease, tRNA-intron endonuclease.
What is the protein family that this protein belongs to?
Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
Protein: RS11_STRPJ
Sequence: MAKPTRKRRVKKNIESGIAHIHATFNNTIVMITDVHGNAIAWSSAGALGFKGSRKSTPFAAQMASEAAAKSAQEHGLKSVEVTVKGPGSGRESAIRALAAAGLEVTAIRDVTPVPHNGARPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: FLAB3_METJA
Sequence: MLLDYIKSRRGAIGIGTLIIFIALVLVAAVAAAVIINTAANLQHKAARVGEESTRQVASGIQVLKITGYAVNTKNITKLAILVSPNVGDEIDLSSTIVTISNGDYKASLVYGGQITYVNTNGTRDIFNESWPNIANPTTEFGVIVLQDADGSMNNTEHPTMNFGDKAIIAINVGDVFGGIMPRERIYGEVIPEFGASGIIEFRAPSTFSEHVVTLQ
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
What are the official names of this protein?
Flagellin B3.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: RXRG_HUMAN
Sequence: MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
What is the function of this protein?
Receptor for retinoic acid.  Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.  The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5.  The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
What are the official names of this protein?
Retinoic acid receptor RXR-gamma, Nuclear receptor subfamily 2 group B member 3, Retinoid X receptor gamma.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: DCTA_ECO81
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRAPDGKTHELSS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YFDF_ECOLI
Sequence: MLPSISINNTSAAYPESINENNNDEVNGLVQEFKNLFNGKEGISTCIKHLLELIKNAIRVNDDPYRFNINNSSVTYIDIDSNDTDHITIGIDNQEPIELPANYKDKELVRTIINDNIVEKTHDINNKEMIFSALKEIYDGDPGFIFDKISHKLRHTVTEFDESGKSEPTDLFTWYGKDKKGDSLAIVIKNKNGNDYLSLGYYDQDDYHIQRGIRINGDSLTQYCSENARSASAWFESSKAIMAESFATGSDHQVVNELNGERLREPNDVFKRYGRAIRYDFQVDDAKYKCDHLKEIVSTLVGNKINVGHSQKIYKHFKDLEGKIEERLQNRQAEYQNEINQPSAPGVNFDDI
What are the official names of this protein?
Uncharacterized protein YfdF.
Protein: PP294_ARATH
Sequence: MAAAPWLYLSRRRSSTQTSLRRFLICSSSFDADEFISSQSRVIGGRGEEEVRFSGALFSRMIHSSTYHPYRQIPLPHSSVQLLDASLGCRGFSSGSSNVSDGCDEEVESECDNDEETGVSCVESSTNPEEVERVCKVIDELFALDRNMEAVLDEMKLDLSHDLIVEVLERFRHARKPAFRFFCWAAERQGFAHASRTYNSMMSILAKTRQFETMVSVLEEMGTKGLLTMETFTIAMKAFAAAKERKKAVGIFELMKKYKFKIGVETINCLLDSLGRAKLGKEAQVLFDKLKERFTPNMMTYTVLLNGWCRVRNLIEAARIWNDMIDHGLKPDIVAHNVMLEGLLRSMKKSDAIKLFHVMKSKGPCPNVRSYTIMIRDFCKQSSMETAIEYFDDMVDSGLQPDAAVYTCLITGFGTQKKLDTVYELLKEMQEKGHPPDGKTYNALIKLMANQKMPEHGTRIYNKMIQNEIEPSIHTFNMIMKSYFVARNYEMGRAVWDEMIKKGICPDDNSYTVLIRGLISEGKSREACRYLEEMLDKGMKTPLIDYNKFAADFHRGGQPEIFEELAQRAKFSGKFAAAEIFARWAQMTRRRCKQRFMED
What are the official names of this protein?
Pentatricopeptide repeat-containing protein At3g62540, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: DNLJ_PROM3
Sequence: MTPTSRTPPERAAELRQLLNQAAHSYYVLDTPTMEDAVYDRLYRELLDLEVKDSSLLTPDSPTQRIGGAPAQGFASVPHRIPLLSLDNAFNVDELTGWYVRLVKLLGYQTNPKTPQPDLSMVGELKIDGNALALSYEHGVLIRAATRGDGANGEEITANVRTIASIPLRLQLVHPPAWLEVRGEAFIPNSTFADINTARGERGDVAFANPRNACAGTLRQLDPKVVASRQLDFFAYTLHLPDNWQAKADDPASPMNQWAVLQWLQAIGFKVNPNTALLTDLTAVEHFFKLWDEARHQLPYATDGVVVKLNDLQLQETAGFTQKAPRWAIALKYAAEEAPSKLLRLTCQVGRTGAVTPVAEFEAIPLAGTSVSRATLHNANRVSELDLHSGDTIVVRKAGEIIPEVIGVLRELRPAGAQTLKLPHICPECRSDLVREEGEAATRCVNNSCPAILRGTLRHWVSKGALDVDGLGSKLIEQLVNRGLVQSIADLYALEASLLASMDRMGNKSTENLITALQASKSKPWHKQLYGLGIHHVGEVNAKALAKKFPSAATLANAACKAPEQITSVFGVGNEIAQSLQQWFATPANQELLAKLKQLGISLEANEDELAHDTDQKQRTVSLQGQTFVLTGTLPTLSRSEAQALIEAAGGKVNSSVSKNTSYVVAGAEAGSKLNKAEKLRVTVLNEEELLKLLAS
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: DNLJ2_DEIDV
Sequence: MDQAASPDDHARYLALRAEVARHNRAYYEQDAPEISDDEYDALARALRDMEARHPEWVEDDSPVQTIGGAPSAAFEPVAHLTPMTSLDNVFDADELREWQEKLARSLNLPPESDDFTFTGEIKIDGLSVNLYYLDGTLQWAATRGNGRVGEMVTAQVLTIPGIPQHLDGLKGQLEVRGEVYLSRADFAAFNAQAEELGTPLLKNPRNGAAGALRQKDPEVTRTRNLKAIFYSLGRRDGVEARTQSEVLQWLAGRGFPVSHYSETFRGYVAAADYHRRMTEARSNFEFDADGTVIKLDPLALQEEAGFTSRAPRWAIAFKFPVEQVETVLESITVNVGRTGKLAPLAHLAPRLIEGSTVSKATLHNEDYIRQMDLRVGDTVVVRKSGGVIPQIMRVVTEKRPEKTTPFVFPTYCPECGHEVTRAEGDANTYCPNPACPAQRFERIRYFVSRGAMDVRGIGEKLVIQVIETGLVRDAADLYLLTAEQLAGLERGGEKKAQNVLAQLEASKTRPLWRLINALGMTHVGERNAQALARAFGSLDALLRATPEQIEAVPGMGKVTAVSVSAALADPTMRNLIERLRAAGMSPEETQTVRGEQLAGLNFVITGSLSQPRDELKALLEAAGARVTGSVTRKTSYLIAGQDAGSKLDRARELAVPVLDEAALGTLLHQRGVQLPGVQASAASTV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase 2, Polydeoxyribonucleotide synthase [NAD(+)] 2.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: BAME_HALED
Sequence: MIDQNHDSEEQAQMQKLTRTVTLTVALTLVSGCSYFGVYKRDLAQGNLVTSAMAEQLQPGMTRQQVVNLMGSPMLEAPFDAQQWDYVYRLDKAYGGVEQRRLTLTFQGNRLADIDRHGDFSRPPSVADERGIGPTDSTNARGNLLNARPDDE
What is the function of this protein?
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
What are the official names of this protein?
Outer membrane protein assembly factor BamE.
What is the protein family that this protein belongs to?
Belongs to the BamE family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TMM72_HUMAN
Sequence: MQLQVFWTGLEYTCRLLGITTAAVLIGVGTETFLQGQFKSLAFYLLFTGAAVSICEGAYFVAQLLAICFQCQPGSLADRVREKAHWLGCFQKFLAYLLLSVACFLHPVLVWHVTIPGSMLIITGLAYFLLSKRKKRKAAPEVLASPEQYTDPSSSAVSTTGSGDTEQTYTFHGALKEGPSSLFIHMKSILKGTKKPSALQPPNTLMELSLEPADSLAKKKQVHFEDNLVRIVPSLAEGLDDGDSEPEETTSDTTPIIPPPQAPLFLSSLTATGLF
What are the official names of this protein?
Transmembrane protein 72, Kidney-specific secretory protein of 37 kDa.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYP_NAUPA
Sequence: MRWSRFFAYTQKEAPKDAVVASHKYLVRGGYIKQVAAGIYDFAPLGKMVLDNIRDIIKKEMDASGAQEVMLTFVTPNELWEETGRAKKYGKELLRIKDRKDQSFVLAPTNEESVVDLVRGTIKSYKQLPVNLYQINLKFRDEARPRFGLLRGREFIMKDAYSFHATEEDLDREFNLMEETYKNIFTKLGLDFRAVWADSGAIGGSGSKEFMVLADTGEDDIVVCSECDYAANIEVATRKHEKRENPVKTEVIEEVHTPDMKSIEDVCNFIGVDPYFSIKAVVKKAIYDDGKSEIVVFFVRGTDTLEETKATNAVGALELVDASEEELEAVGLVPGFIGPFGLPSSVRYIIDDDLRMAEELVCGANKKDYHIKGAGLLDANLLGNLTVYRDIAAVKEGDKCPKCGAPLKITKGIEVGHIFKLGTVYSEPMNATFLDENGKAKPFIMGCYGIGVSRLISAAIEQNHDDKGIIWPKQIAPFVVDIIVGDVKKDEQLIFAEDLYDKLTSAGVKTILDDRAERFGPKIADFELVGFPVCVIVGKKLKDGKVEVRDRRTGEKFEVEKDMALEKVMEIINN
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLYA1_PECAS
Sequence: MLKREMNIADYDADLWQAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDIVEQLAIDRAKALFGADYANVQPHSGSQANFAVYTALLQPGDTILGMNLAHGGHLTHGSPVNLSGKLYKVIPYGIDESGKIDYDEMAELARTHQPKMIVGGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGLIAADVYPNPVPHAHIVTTTTHKTLAGPRGGLILAKGGDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVALKEAMEPEFKVYQQQVAKNAKAMVEVFLSRGFNVVSGATSNHLFLLDLVSKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGIRIGTPAATRRGFKEAEVRELAGWICDVLDNINDEATIERVKQKVLDICARFPVYA
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase 1, SHMT 1, Serine methylase 1.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAA_CLONN
Sequence: MNAQLKQLWTKTLNIIKGELTEVSFNTWIKSISPISMNENTIKLEVPNDFTRGILESRYKDLIINAIKLITSKKYNIEFSITSEEIFNNQQLKPKSSNDNIVVNDEMTSILNPKYTFDSFVIGNSNRFAHAASLAVAESPAKAYNPLFIYGGVGLGKTHLMHAIGHYILQNTPNAKVVYVSSEKFTNELINSIKDDKNEEFRNKYRNVDVLLIDDIQFIAGKERTQEEFFHTFNALYEADKQIILSSDRPPKEIPTLEDRLRSRFEWGLIADIQAPDFETRIAILKKKADVENLDIPNEVMVYIATKIKSNIRELEGALIRIVAYSSLTNREISVDLAAEALKDIISSEQNKQITIELIQDIVCNYFNLKIQELKSSRRTRNIAFPRQIAMYLSRKLTDMSLPKIGEEFGGRDHTTVIHAYEKISNILKKDESLRNVIDDLNKKITNN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB2_OLEA2
Sequence: MARHIKVLIVDDSALVRQTLTDIFSADPELEVVGTASDPFVAVKRMETVVPDVILLDVAMPRMDGLTFLRKIMSQHPIPVVICSAVTEQGAEASFKAMEYGAVEIIQKPKVSTKQFLEESSIRICDAVKAAARAQLRKLAAKRFEVTPKLSADAMLPANAGRSVVQRTEKVVVVGASTGGTEALRVLLEAMPPDCPPIAIVQHMPEHFTAAFAGRLNSTCRIQVKEASDGDVMQRGQALIAPGNLHLLLKRSGSRYYVETKEGPLVRRHRPSVDVLFRSAARYAGNNAVAAIMTGMGDDGAAGMKELHETGAYTIAQDEATCVVYGMPHEAVKLGGVDAVLPLGALAAAIVKACNS
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 2.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.