PharMolix/UniProtQA huggingface dataset:
Protein: P3_RDVA
Sequence: MDSTGRAYDGASEFKSVLVTEGTSHYTPVEVYNILDELKTIKITSTIAEQSVVSRTPIPLSKIGLQDVKKLFDINVIKCGSSLRIVDEPQVTFIVSYAKDIYDKFMCIEHDSAYEPSLTMHRVRVIYSMLNDYCAKMISEVPYESSFVGELPVKSVTLNKLGDRNMDALAEHLLFEHDVVNAQRENRIFYQRKSAPAVPVIFGDDLEPAVRERANLYHRYSVPYHQIELALHALANDLLSIQYCHPTVVYNYLSSRAPNFLRLDDQVSLKLTSAGIGTLMPRPVVQLLDYDLVYMSPLALNNLASRLLRKISLHLVMQMVTAVQQDLGEVVSVSSNVTNPASACLVRMNVQGVQTLAVFIAQSMLNPNISYGMISGLTLDCFSNFIYGACLMLFQALIPPSALTARQRLDINNRFAYFLIKCHATQATTARLVANQVIYPVDAIDQWQSNGRDVLVAIYNNLLPGELVLTNLIQTYFRGNTAQQAAEILIPADQTSYGANETRALSAPYLFGAPINMLAPDARLSTYKRDLALPDRSPILITTVEGQNSISIENLRHKTGLIRAMYLNGFVTQPPAWIRNANSNTALLSRFLDATPNLLGIYEAILANTYANAVNVYCDSVYRADIPIEWKLHQSVDPQDLLFGVFGIVPQYQILNEAVPDFFAGGEDILILQLIRAVYDTLSNKLGRNPADIFHLEEVFKVIEEIVSVLVQQKIDVRKYFTESMRSGSFSKPRWDNFLRRPVAQRLPNLYSVIMTQADHVYNYMTQLTHIIPITDCFYIVKNSGFVDRGSTGPVIASSSVYENVLKVVHTIADFDAANALRLQRRRVDNTSYTDSLSDMFNGLRSISSSEFVRSVNGRSVFTEGRIDAIKVNMRAKFDLQFITEEGGYSKPPNVKKLMFSDFLSFLDSHKSDYRPPLLTVPITIGLNNLGETNSNTLRMRSEAIDEYFSSYVGAQILVPINVVDTRVYTEFSELRNFFTGDVVIRDDPFDVWDGVKATYIPIGVHGVRLDPNGDQPPL
What is the function of this protein?
Capsid protein which self-assembles to form the inner icosahedral capsid with a T=2 symmetry, and consisting of 60 P3 dimers.
What are the official names of this protein?
Outer capsid protein P3, Core protein P3.
What is the protein family that this protein belongs to?
Belongs to the phytoreovirus inner capsid protein P3 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Found in the interior of spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: RL14_BURP1
Sequence: MIQTESRLEVADNTGAREVMCIKVLGGSKRRYASIGDIIKVSVKEATPRGRVKKGEIYNAVVVRTAKGVRRQDGSLIKFDGNAAVLLNNKLEPIGTRIFGPVTRELRSERFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RL37A_METST
Sequence: MVKKSKVGSTGRFGARYGRKAKRTVKDIEDKMHAKHVCPKCDRPGVKRTHAGIWKCRKCGAVFTGGAYIPTTPMGKVAKRNIKRITGGE
What are the official names of this protein?
50S ribosomal protein L37Ae, Ribosomal protein L43e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein: RS10_BURM1
Sequence: MQQQKIRIRLKAFDYRLIDQSAAEIVDTAKRTGAIVRGPVPLPTRIQRFDILRSPHVNKTSRDQLEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKLQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: COX9_YEAST
Sequence: MTIAPITGTIKRRVIMDIVLGFSLGGVMASYWWWGFHMDKINKREKFYAELAERKKQEN
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 9, mitochondrial, Cytochrome c oxidase polypeptide VIIA.
What is the protein family that this protein belongs to?
Belongs to the fungal cytochrome c oxidase subunit 7a family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: DAPA_DESRM
Sequence: MSTVDFGRVITAMVTPFHPDMSVNYTQAKKLSRYLVENGSDGLVVSGTTGESPTLNKDEKIQLFKAVVEEVGGQATVIAGTGSYDTASSIILTKEAEKVGCDGVMLVAPYYNKPSQEGLYQHFRTIAECTSLPVMLYNIPGRTGINVLPATVERLAKDVPNIVAIKEAAGDINQVSELRRILPEDFIIFSGDDSLTLPMLSLGCKGIVSVAAHIAGKQIQEMIDAFTSGNTTLAANLHKELFPIFKGLFITSNPVPVKAALNLKGLAVGGVRLPLVEATAKEIETVKNIMNNLHLL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PANC_THEM4
Sequence: MEVIKSIDKMKQISFENILKGKKIGFVPTMGYLHEGHLSLVRAAREENDILVVSIFVNPTQFGPNEDFESYPRDLKRDLSLLEKENVDYVFVPEVSDMYPNDYSTFVEEVVLSKFLCGASRPGHFRGVCTVVTKFFNIVKPTRAYFGQKDAQQFRVLRRMVRDLNLDVELREMPIVRELDGLAMSSRNTYLNDVERNEATRLYKSLLKAKELIEKGEKDVLKIKDEMKKILDHPLLKIDYIEFVDEETLRPVEKIEGKVIVAIAVFVGKARLIDNIIVGG
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_GEOMG
Sequence: MEDILGEWKRSHYCGNLTKADVGREVILMGWILRRRDHGGLIFADLRDREGLAQIVFDPAKNTDAHHKAEAIRNEYVVAVKGEVIPRPEGTVNSAMKTGEVEVLVTECKILNRSKALPFTLDDYVDVAENIRLKYRYLDLRRPVLQQNLILRSMVAQITRQYLSENGFLEIETPFLTKSTPEGARDFLVPSRINQGNFYALPQSPQIFKQILMISGFDRYFQIVRCFRDEDLRADRQPEFTQIDCEMSFIDREDIISVMEGLIAKIFTVAKGVDVPLPMPRMTYAEAIRRFGVDNPDVRFGLELVELTDIVKGAGFKVFADVAASGGIIKGLNAKGCARFSRKEIDDLTEFAKIYGAKGLAYVKIEEGQWHSPIAKFFSAEEIATMNQAFGAEDGDLLLFVADKPKVVNDSLGKLRNHLAGILGLADKNTFRFVWITDFPLLEWDEDEKRWAAVHHPFTAPMDEDLEKVESDPGSCRAKAYDLVLNGNEIGGGSIRIHQQHVQSLMFSMLGLSDDETRAKFGFLLDALECGTPPHGGIAFGMDRLIMLLTGSDSIRDVIAFPKTQKGACLMSEAPSPVDAKQLRELALKVTVKQ
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OADC_BRADU
Sequence: MAFRSRREKLRSILSGPGCIHPGSVYDAISIRIAEDLGFPLGMFGGSVASLAVLGDPDITLITLTELAEQMRRMSRASALPVLVDADHGYGNALNVRRTVQELETAGAAGLTIEDTLLPAAFGEAKTQLISLEEGVGKMKAALSGRSDPTLVIMGRTGAAAITSLDDTIRRAQAYEATGVDALFFTGIKSRAELEAVAAATHLPIVLGGAPEELNAPDYLAGQRVRIALQGHAPIAAATQAVHDTLKALREGAPPKALKGLASAELTSRVMREAETKARGADVLGFKK
What is the function of this protein?
Catalyzes the decarboxylation of oxaloacetate into pyruvate.  Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate.
What are the official names of this protein?
Oxaloacetate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family.
Protein: NRM_PIG
Sequence: MAPALLLVPAALASFILAFGTGVEFVRFTSLRPLLGGIPESGGPDARQGWLAALQDQSILVPLAWDLGLLLLFVGQHSLMATETVKAWMSRYFGVLQRSLYVACTALALQLVMRYWEPVPRGPVLWEAQAEPWATWVPLLCFVLHVISWLLIFSILLVFDYAELMGLKQVYYHVLGLGEPLALKSPRALRLFSHLRHPVCVELLTVLWVVPTLGTDRLLLALLLTLYLGLAHGLDQQDLRYLRAQLQRKLHLLSRPQDGEAE
What are the official names of this protein?
Nurim, Nuclear envelope membrane protein, Nuclear rim protein.
What is the protein family that this protein belongs to?
Belongs to the nurim family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein.
Protein: RECA_SERP5
Sequence: MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYAKKLGVDIDNLLCSQPDTGEQALEICDALTRSGAVDVIIVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKNANTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGDEVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINSRGELVDLGVKHKMIEKAGAWYSYNGDKIGQGKANACNFLKENPAVAAELDKRLRDLLLHSNGELVAATNEGFDDEAETSEEF
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSBW_STAAB
Sequence: MQSKEDFIEMRVPASAEYVSLIRLTLSGVFSRAGATYDDIEDAKIAVSEAVTNAVKHAYKEKNNVGIINIYFEILEDKIKIVISDKGDSFDYETTKSKIGPYDKDENIDFLREGGLGLFLIESLMDEVTVYKESGVTISMTKYIKKEQVRNNGERVEIS
What is the function of this protein?
Negative regulator of sigma-B activity.  Phosphorylates and inactivates its specific antagonist protein, RsbV.  Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
What are the official names of this protein?
Serine-protein kinase RsbW, Anti-sigma-B factor, Sigma-B negative effector RsbW.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: ACTN4_MOUSE
Sequence: MVDYHAANQAYQYGPNSGGGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKQRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPSLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL
What is the function of this protein?
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures.  This is a bundling protein.  Probably involved in vesicular trafficking via its association with the CART complex.  The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity).  Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2.  Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (PubMed:18332111).  May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (By similarity).
What are the official names of this protein?
Alpha-actinin-4, Non-muscle alpha-actinin 4.
What is the protein family that this protein belongs to?
Belongs to the alpha-actinin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell junction. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, perinuclear region. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (PubMed:33228246).
Protein: GLPK_LIGS1
Sequence: MSDKYIMAIDEGTTSTRAIIFDKKGNKVAEGQKEFRQYFPQPGWVEHDANEIWNAVLSTIANSFISSGIQPKQIAGIGITNQRETTIIWDKETGLPIYNAIVWQSRQTSDIAQKLIDEGYSDTIHEKTGLIIDAYFSATKIRWILDHVEGAQERAEKGELLFGTIDTWLTWKLTGGKVHVTDYSNASRTMLFNIHDLKWDKEILELLNIPEALLPEVKGNSEIYGQTAAYHFFGSQVPISGMAGDQQSALFGQLALEDGTVKNTYGTGSFIVMNTGNKPVLSKNNLLTTIGYSIDGKINFALEGSVFVSGSALQWLRDSMEIIESAPESERAANESTNHNEVYVVPAFTGLGAPYWDSDARGAVFGLTRGTTKNDFIKATLQSLAYQTRDVLDTMEKDTGIKIPVLRVDGGAAMNNYLLQFQSDLLNKSVERAGNLETTALGVAFLAGLAVGFWKDTDELKELFTVGRRFEPEMSDDAREYLYAGWKNAVEATRIFKHKINENL
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: MUG_ECO24
Sequence: MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQLKPQEAQHLLDYRCGVTKLVDRPTVQANEVSKQELHAGGRKLIEKIEDYQPQALAILGKRAYEQGFSQRGAQWGKQTLTIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR
What is the function of this protein?
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA.  It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base.  The complementary strand guanine functions in substrate recognition.  Required for DNA damage lesion repair in stationary-phase cells.
What are the official names of this protein?
G/U mismatch-specific DNA glycosylase, Double-strand-specific uracil glycosylase, Mismatch-specific uracil DNA-glycosylase, MUG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1B_CENSY
Sequence: MAQLLVIVKILPKGTEVDLDEMMEGLKGGLKGGIVLRRYAKEPLAFGLHFVKAEFILEDKEGQNDALEATVRSAKGVSEYEVLNMSRMSVDMK
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: SYH_BACCN
Sequence: MSIQIPRGTQDILPGSVELWQYIEGQAREICRRYNYKEIRTPIFEHTELFLRGVGDTTDIVQKEMYTFQDRGDRSLTLRPEGTAPVVRSYVENKMFGDATQPTKLYYIGQMFRYERPQAGRYRQFVQFGIEAIGSNDPAIDAEVIALAVEFYRGMGLKNIKVVLNSLGDPASRQAHREALIAHFKPRIGEFCSDCQSRLEKNPLRILDCKRDRDHELMNTAPSITDYLNEESTAYYEKVQELLTMMGVPFEKDPNLVRGLDYYQHTVFEIMSEAEGFGAITTLSGGGRYNGLVQEIGGPEMPGIGFAMSIERLIMALKAENIELPIENTIDCYVVALGDKAKDHAAKVAFDLRKSGLSVEKDYLNRKMKAQFKSADRLNAKYVAVLGEDELDKGVINLKDMATGEQEEVALDVFASYIAEKLI
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVD_METMJ
Sequence: MRSETVKKGYQRAPNRALLRSLGVTDREMDLPFIGIANAYNNIVPGHLHLRSISQKVQEGVAAAGAVPFEFGTIGICDGIAMGHEGMRYSLPSRENIADAVELMVEAHRFDGLVCVCTCDKIVPGMLMAAVRCNIPAIVVTGGPMLPGYAAGRELSLIDVFEGVGRVAAGTMSEEELGELECAAMPGCGSCQGLYTANTMACVTEALGLSLPGCAAIPAVDAAKLRIARESGERVVGLVREGVRPRDLVTPKSLANAIRVDMALGGSSNTVLHLMAVAREAAVPLDLEAFNAVAEVTPHICHMMPGGPHSMLALYRAGGIPAVLKMLERHLDDAPTVSGRSILEIAKGARVADPDVIRTTDAPVSPAGGLKIVRGSLAPDGAVVKCAAVPEAMWRHRGPARVFDGEGAAMEAILHREIAEGDVLVIRYEGPRGGPGMPEMLSPTSALMGLGYARVALVTDGRFSGGTRGPCIGHIAPEAAVGGPIALVEDGDEIVIDLYAKSLDLAVERATLEERRKTWKPPARRLTGMLARYVQTVEQANLGAVQR
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: LGT_TROWT
Sequence: MHFYIPPPPISGFWLGPLYVHMYSVFMLAGALVLFELTNRRFIVLTGNREFTAFAVTSLLIPVILGARLWHVVSHTQMYEHQPFYKVFAIWEGGLGFIGGVFSGLICFFVIAKIKKVPPFTFLDALAPGILAALCFARLGNYFNGEVFGTETTLPWGLKLSHEGFKDLNVEKYFHPIFLYEIILNVFIIVILLVLEKRVFVKTVFPKGSVFAAFLVLYGLGRFALEPMRYNLQQNSFGLDLNYVGAAAMIIVGVLIACRHTIASGKLRNSGD
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXT_SALTO
Sequence: MTAPVIGVLALQGDVREHTAALAAAGADARPVRRPKELETVDGLVIPGGESTTISRLVDLFELREPIDKRIADGMPVYGSCAGMIMLASEVLDGRSDQRGFAGIEMTVRRNAFGRQIASFEAPVSMAGIDGDPLHVLFIRAPWVERVGRGVEVLGTVAEGPAAGRIVAVRQGNLLATSFHPELTDDRRLHAYFADLVRAAI
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: GSA1_BACP2
Sequence: MKFTESEKLHQEALEHIVGGVNSPSRSYKAVGGGSPVAMEKGEGAYFWDVDGNRYIDYLAAYGPIITGHAHPHITKAITKAAESGVLYGTPTKHEVTFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPKSIANEVITVPFNDIDSYKEALDRWGDEVAAVLVEPIVGNFGIVEPKDGFLQQVNDLTHEKGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKQDGVYERLDQLGAMLEEGILAHAKKHQVDITVNRLKGALTVYFTKETIVNYEQAENTDGEMFARFFKLMLSQGINLAPSKYEAWFLTIAHTEKDISETLQAVDRAFEQLKQS
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 1, GSA 1, Glutamate-1-semialdehyde aminotransferase 1, GSA-AT 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TET2_HUMAN
Sequence: MEQDRTNHVEGNRLSPFLIPSPPICQTEPLATKLQNGSPLPERAHPEVNGDTKWHSFKSYYGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTVSEPSLSGLLQIKKLKQDQKANGERRNFGVSQERNPGESSQPNVSDLSDKKESVSSVAQENAVKDFTSFSTHNCSGPENPELQILNEQEGKSANYHDKNIVLLKNKAVLMPNGATVSASSVEHTHGELLEKTLSQYYPDCVSIAVQKTTSHINAINSQATNELSCEITHPSHTSGQINSAQTSNSELPPKPAAVVSEACDADDADNASKLAAMLNTCSFQKPEQLQQQKSVFEICPSPAENNIQGTTKLASGEEFCSGSSSNLQAPGGSSERYLKQNEMNGAYFKQSSVFTKDSFSATTTPPPPSQLLLSPPPPLPQVPQLPSEGKSTLNGGVLEEHHHYPNQSNTTLLREVKIEGKPEAPPSQSPNPSTHVCSPSPMLSERPQNNCVNRNDIQTAGTMTVPLCSEKTRPMSEHLKHNPPIFGSSGELQDNCQQLMRNKEQEILKGRDKEQTRDLVPPTQHYLKPGWIELKAPRFHQAESHLKRNEASLPSILQYQPNLSNQMTSKQYTGNSNMPGGLPRQAYTQKTTQLEHKSQMYQVEMNQGQSQGTVDQHLQFQKPSHQVHFSKTDHLPKAHVQSLCGTRFHFQQRADSQTEKLMSPVLKQHLNQQASETEPFSNSHLLQHKPHKQAAQTQPSQSSHLPQNQQQQQKLQIKNKEEILQTFPHPQSNNDQQREGSFFGQTKVEECFHGENQYSKSSEFETHNVQMGLEEVQNINRRNSPYSQTMKSSACKIQVSCSNNTHLVSENKEQTTHPELFAGNKTQNLHHMQYFPNNVIPKQDLLHRCFQEQEQKSQQASVLQGYKNRNQDMSGQQAAQLAQQRYLIHNHANVFPVPDQGGSHTQTPPQKDTQKHAALRWHLLQKQEQQQTQQPQTESCHSQMHRPIKVEPGCKPHACMHTAPPENKTWKKVTKQENPPASCDNVQQKSIIETMEQHLKQFHAKSLFDHKALTLKSQKQVKVEMSGPVTVLTRQTTAAELDSHTPALEQQTTSSEKTPTKRTAASVLNNFIESPSKLLDTPIKNLLDTPVKTQYDFPSCRCVEQIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCRQRKLEAKKAAAEKLSSLENSSNKNEKEKSAPSRTKQTENASQAKQLAELLRLSGPVMQQSQQPQPLQKQPPQPQQQQRPQQQQPHHPQTESVNSYSASGSTNPYMRRPNPVSPYPNSSHTSDIYGSTSPMNFYSTSSQAAGSYLNSSNPMNPYPGLLNQNTQYPSYQCNGNLSVDNCSPYLGSYSPQSQPMDLYRYPSQDPLSKLSLPPIHTLYQPRFGNSQSFTSKYLGYGNQNMQGDGFSSCTIRPNVHHVGKLPPYPTHEMDGHFMGATSRLPPNLSNPNMDYKNGEHHSPSHIIHNYSAAPGMFNSSLHALHLQNKENDMLSHTANGLSKMLPALNHDRTACVQGGLHKLSDANGQEKQPLALVQGVASGAEDNDEVWSDSEQSFLDPDIGGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALWEAKMAEKAREKEEECEKYGPDYVPQKSHGKKVKREPAEPHETSEPTYLRFIKSLAERTMSVTTDSTVTTSPYAFTRVTGPYNRYI
What is the function of this protein?
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation.  Has a preference for 5-hydroxymethylcytosine in CpG motifs.  Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).  Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation.  Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation.  In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
What are the official names of this protein?
Methylcytosine dioxygenase TET2.
What is the protein family that this protein belongs to?
Belongs to the TET family.
Protein: MHPB_CUPNE
Sequence: MPIQLECLSHTPLHGYVDPAPEVVAEVERVQAAARDRVRAFDPELVVVFAPDHFNGFFYDVMPPFCIGAAATAIGDFKSLAGKLPVPADLALSLAESVMAADIDVALSHRMQVDHGCADALAALTGSLHRYPVIPVFINSVAPPMATLRRARLLGDAVGRFLSRAGKRVLVVGSGGISHEPPVPELAGASEEVAERLIAGRNPSPESAARQARTVAAAKSFVAGDSHLHPLNPEWDRAFLSLLASGELTAVDGMTNDAITRDGGKSAHEIRTWVAAFGALAAYGPYRASLDFYRAIPEWIAGFATMHAEPAAV
What is the function of this protein?
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.  Also catalyzes the cleavage of catechol.
What are the official names of this protein?
2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase, 3-carboxyethylcatechol 2,3-dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the LigB/MhpB extradiol dioxygenase family.
Protein: RL18_SALG2
Sequence: MDKKSARIRRATRARRKLKELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.