PharMolix/UniProtQA huggingface dataset:
Protein: ITA3_BOVIN
Sequence: MGPGPSRAAGVLRPLLGMLALMVAASNRAASAFNLDTRFLVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRDLAVPDGYTNRTGAVYLCPLTAHKNDCERMDIKEKSNPNHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCYVRGNDLELDARDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKDWDLSEYSYKDPEDQGNLYIGYTMQVGSAILHPTNITIVTGAPRHQHVGAVFLLSQEAGGDLRRRQVLEGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAIYIFMNQAGTSFPDHPSLLLHGPSRSAFGFSVASIGDVNQDGFQDIAVGAPFEGLGKVYIYHGSSRGLLRQPQQVIHGEQLGLPGLATFGYSLSGQMDVDENFYPDLLVGSLSDRIVLLRARPVINILHKTLVAKPSILDPAFCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLHFARSQSAVFHGFFSMPEMRCQTLELLLMDNVRDKLRPITISMNYSLPLRLPDRPQLGLGSLDAYPVLNQAQALENHTEVQFQKECGQDNRCDSNLQMRAAFVSELGQRLSRLQYRRDLRKLLLSINVTNTPSRKRAGEDAHEALLTLEVPPTLLLSSVRPPGACQANETIVCELGNPFKRNQRMELLIAFEVIGVTLHTRELQAQLQLSTSSHQDDLRPMTLPLLVDYTLQASLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYEFQVGPMGEGLAALGTLVLGLEWPYEVSNGKWLLYPTEITVHGNGSWHCQPPGDLINPLNLTLSVPGDGPPSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSEIQLSCGSDHTHCVWLECPIPDAPVITNVTIQARVWNSTFIEDYRDFDRVRVASWATLFLRTGVPTINMENKTVRFSVDIDSDLVEELPAEIELWLVLVAVSAGLLLLGLIILLLWKCGFFKRARTRALYEAKRQKAEMKSQPSETERLTEDY
What is the function of this protein?
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4.  Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.  Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
What are the official names of this protein?
Integrin alpha-3, CD49 antigen-like family member C, Galactoprotein B3, GAPB3, VLA-3 subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the integrin alpha chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner.
Protein: CINAL_GEOMG
Sequence: MKTALLSIGDELLLGEVVDTNSARIAARLADEGIVTARKLTVGDDEGEIAGALEELARGHDVVIATGGLGPTDDDVTARAAARATGRRLVLNEEAMGHLREFFVRLGREMHPANGRQCLLPAKAELIPNPTGTASGFYLPLDRCLLMFLPGVPSEMAVMLDETVVPLVLERRGEHRRTRTLTLTVFGLSEAEIGARLSDLDRSRPGLTVAYCVEYPVVQVKLRATGEDEGALTALLEDGAALVRERLGGHVVAGDGETIDTTVARLFRETGMTLALAESCTGGLIAGRVTAIPGSSAYFFLSAVTYANDAKARLLGVPQGLLAETGAVSAEVAKAMARGARQLAGSDLALAVTGIAGPEGGSPDKPVGTVFIALADQAGCSAKGYHFRGDRDRIRTITAVTAMDWLRRRLLSH
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: RL21_YERPY
Sequence: MYAVFQSGGKQHRVSEGQTIRLEKLDIATGETIEFDQVLMIANGEEINIGAPLVDGGKIKAEIIAHGRGEKIKIVKFRRRKHYRKQQGHRQWFTDVKITGISA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: Y825_VIBVU
Sequence: MSLKNLPSESMPREKLLQRGPQSLSDAELLAIFLRTGTQGMNVIELADFLLRDFGSLRKLFSADEQSFCRHKGLGQAKYVQLQAVLEMTQRYLAETLQRGDALTSPQHTKLYLSSMLRDRHREAFYVLFLDNQNRVIKDEVMFEGTIDAASVYPREVVKRALHYNAAALILAHNHPSGVAEPSQADRRITRRLSDALGLVDIRVLDHFVVGDGEVVSFAERGWI
What are the official names of this protein?
UPF0758 protein VV1_0825.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: RIMO_SHESR
Sequence: MTVETFNPKQTTTLETPAKTLEAASADSTATGNRIGFVSLGCPKNLVDSERILTQLRIDGYEVTNSYDNADLVIVNTCGFIDAAVEESLDAVREALEENGKVIVTGCLGAKENQIREVHPDVLEITGPHSYEAVLKHVHKYVPKPEHNPFTSLIPQTGVKLTPKHYAYLKISEGCDNRCTFCIIPALRGDLDSRPAGSVLDEAKRLVESGVQEILVVSQDTSAYGKDKGGRTDFWNGMPVKQDITSLARQLGKMGAWVRLHYIYPYPWVDDLIPLMAEGLILPYLDIPMQHASPRILKMMKRPGRVDRQLEAIQRWREICPDLVIRSTFIVGFPGETEEDFEMLLDFLREARLDRVGCFKYSEVEGAVANTIAELISEDVKEDRYHRFMEVQAEISAERLARFVGRTMDILIDDVDEEGAIGRSFADAPEIDGMVFINGETELEPGMLVRAVITHSDEHDLWAELVDADAEDDIEA
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARND_SHIF8
Sequence: MTKVGLRIDVDTFRGTREGVPRLLEILSKHNIQASIFFSVGPDNMGRHLWRLVKPQFLWKMLRSNAASLYGWDILLAGTAWPGKEIGHANADIIREAAKHHEVGLHAWDHHAWQARSGNWDRQTMIDDIARGLRTLEEIIGQPVTCSAAAGWRADQKVIEAKEAFHLRYNSDCRGAMPFRPLLESGNPGTAQIPVTLPTWDEVIGRDVKAEDFNGWLLNRILRDKGTPVYTIHAEVEGCAYQHNFVDLLKRAAQEGVTFCPLSELLSETLPLGQVVRGNIAGREGWLGCQQIAGSR
What is the function of this protein?
Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
Protein: HIS3_CHLPD
Sequence: MSENEDLQKSFLDTVKYDEKGLVPAIVQDHETGKVLMMAWMNHESLLMTLEKKKACYWSRSRQKLWLKGESSGNMQDVHDILIDCDGDTILLKVSQKGGACHVGYHSCFYRKVKETLDMEICDTLMFNPDDVYGKKS
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPP_SALDC
Sequence: MNEQYSALRSNVSMLGKVLGETIKDALGEHILDRVETIRKLSKSSRAGNEANRQELLTTLQNLSNDELLPVARAFSQFLNLANTAEQYHSISPKGEAASNPEVIARTLRKLKNQPDLNDATIKKAVESLSLELVLTAHPTEITRRTLIHKMGEINNCLKQLDNTDIADYERHQVMRRLRQLIAQSWHTDEIRKQRPSPVDEAKWGFAVVENSLWQGVPNYLRELNEQLEENLGYKLPVDFVPVRFTSWMGGDRDGNPNVTADITRHVLLLSRWKATDLFLKDIHVLVSELSMVDATPELLALVGEEGASEPYRYLMKKLRARLMATQSWLEARLKGEKLPKPAGLLTQNEQLWEPLYACYQSLQACGMGIIANGELLDTLRRVKCFGVPLVRIDIRQESTRHTEALGEITRYLGIGDYESWSEADKQAFLIRELNSKRPLLPRNWEPSNDTREVLETCKVIAEAPKGSIAAYVISMAKTPSDVLAVHLLLKEAGIGFAMPVAPLFETLDDLNNADDVMTQLLNIDWYRGLIQGKQMVMIGYSDSAKDAGVMAASWAQYQAQDALIKTCEKAGIELTLFHGRGGSIGRGGAPAHAALLSQPPGSLKGGLRVTEQGEMIRFKYGLPEVTVSSLSLYTSAILEANLLPPPEPKDSWRHIMDELSVISCETYRGYVRENKDFVPYFRSATPEQELGKLPLGSRPAKRRPTGGVESLRAIPWIFAWTQNRLMLPAWLGAGTALQKVVEDGKQSELEAMCRDWPFFSTRLGMLEMVFSKADLWLADYYDQRLVAKTLWPLGKELRDLLEEDIKVVLAIANDSHLMADLPWIAESIQLRNVYTDPLNVLQAELLYRSRLTEEQGKSPDPRVEQALMVTIAGVAAGMRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: PLX1_PHYSA
Sequence: MVFLKKSLLLVLFVGLVSLSICEENKREEHEEVEENAEKAEEKRGWMSKIASGIGTFLSGVQQG
What is the function of this protein?
Antimicrobial peptide against both Gram-positive and Gram-negative bacteria.
What are the official names of this protein?
Phylloxin-S1, PLX-S1, Phylloxin.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Phylloxin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SECB_COXB2
Sequence: MAEQNQRTNTPDNGSEFAIQRLYIKDLSFEAPRSPQVFLEEWQPELNMDLATKVNDLGEDNHEVVLTVTVTVTMKESHIFLAEVQQGGIFTIKNFPKEEMRPMLGSFCPNILYPYAREAITDMVVRGGFPQLYLAPVNFDALFEQHEQSEEGNSGTEDRVH
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCAD_SALSV
Sequence: MSTYTRPVMLLLCGLLLLTLAIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIVNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLRNAGQTPNPVAHI
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ILVC_STRAW
Sequence: MAELFYDADADLSIIQGRKVAVIGYGSQGHAHALSLRDSGVDVRVGLHEGSKSKAKAEEQGLRVVTPSEAAAEADVIMILVPDPIQAQVYEESIKDNLKDGDALFFGHGLNIRFGFIKPPAGVDVCMVAPKGPGHLVRRQYEEGRGVPCIAAVEQDATGNGFALALSYAKGIGGTRAGVIKTTFTEETETDLFGEQAVLCGGTAALVKAGFETLTEAGYQPEIAYFECLHELKLIVDLMYEGGLEKMRWSISETAEWGDYVTGPRIITDATKAEMKKVLAEIQDGTFAQAWMDEYHGGLKKYNEYKTQDENHLLETTGKELRKLMSWVNDEEA
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RAPZ_ECO5E
Sequence: MVLMIVSGRSGSGKSVALRALEDMGFYCVDNLPVVLLPDLARTLADREISAAVSIDVRNMPESPEIFEQAMSNLPDAFSPQLLFLDADRNTLIRRYSDTRRLHPLSSKNLSLESAIDKESDLLEPLRSRADLIVDTSEMSVHELAEMLRTRLLGKRERELTMVFESFGFKHGIPIDADYVFDVRFLPNPHWDPKLRPMTGLDKPVAAFLDRHTEVHNFIYQTRSYLELWLPMLETNNRSYLTVAIGCTGGKHRSVYIAEQLADYFRSRGKNVQSRHRTLEKRKP
What is the function of this protein?
Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ.  When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E.  Consequently, GlmZ is inactivated and unable to activate GlmS synthesis.  Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
What are the official names of this protein?
RNase adapter protein RapZ.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family. RapZ subfamily.
Protein: SSUB1_PSEU2
Sequence: MPESLMDIRVEHKAFAGNTVLHGIDLSLQSGEIVSLLGPSGCGKSTLLRIVAGLEQDFRGSVQRIQGEVAFVFQEPRLMPWLTVAQNIGFSDDDRYDRRWVAQLIEEVGLSGFADALPKALSGGMAQRVAIARGLYSHPAVLLLDEPFSAVDAFTRMKLQDLLLQLAARHAITLLLVTHDVDEALYLSDRVLVMGSRPGTITHQLPVGLQTPRDRRDPLLARLKAQALTELQQAHVI
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RECR_PSEAB
Sequence: MSFSPLIRQLIESLRILPGVGQKSAQRMALMLLERDRSGGLKLAQALTAAMEGVGHCRRCRTLSEEELCPQCADPRRDDSLLCVVEGPLDVFAVEQTGYRGRYFVLKGHLSPLDGLGPEAIGIPELEARIRDGAFSEVILATNPTVEGEATAHYIAQLLAGRGLTLSRIAHGVPLGGELELVDGGTLAHALAGRRPIS
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: KBX32_OPICA
Sequence: MNNKLTALIFHGLLAIASCKWLNEKSIQNKIDEKIGKNFLGGMAKAVVHKLAKNEFMCMANMDPTGSCETHCQKASGEKGYCHGTKCKCGVPLSY
What is the function of this protein?
Has antimicrobial activity against yeasts and bacteria.
What are the official names of this protein?
Opiscorpine-2.
What is the protein family that this protein belongs to?
Belongs to the long chain scorpion toxin family. Class 3 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CPS2_STRCC
Sequence: MTEMTEKATTFLTSQEAPAFPADRTCPYQLPTAYSRLRDEPDALRPVTLYDGRRAWVVTKHEAARRLLADPRLSSDRLHADFPATSPRFKAFRQGSPAFIGMDPPEHGTRRRMTISEFTVKRIKGMRPDVERIVHGFIDDMLAAGPTADLVSQFALPVPSMVICHMLGVPYADHEFFQDASKRLVQAVDADSAVAARDDFERYLDGLITKLESEPGTGLLGKLVTHQLADGEIDRAELISTALLLLVAGHETTASMTSLSVITLLEHPDQHAALRADPSLVPGAVEELLRVLAIADIAGGRIATADIEIDGQLIRAGEGVIVTNSIANRDSSVFENPDRLDVHRSARHHLSFGYGVHQCLGQNLARLELEVILTVLFDRIPTLRLAVPVEQLTLRPGTTIQGVNELPVTW
What is the function of this protein?
Catalyzes the hydroxylation of sodium ML-236B carboxylate to pravastatin.
What are the official names of this protein?
Cytochrome P450 105A3, Cytochrome P450 sca-2, CYT P-450sca-2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: ANMK_SHESA
Sequence: MNKAYYIGLMSGTSMDGVDAVLVDFAGEQPQLIATHTEAIPSHLLKGLQRLCLPGNDEINRLGRLDRSVGKLFALAVNNLLAKAQIAKEDIIAIGSHGQTVRHMPNLEVGFTLQIGDPNTIATETGIDVIADFRRKDIALGGQGAPLVPAFHQQTFAQVGKKRVILNIGGIANITYLTGNREEVLGFDTGPGNTLIDAWIQQVKNEPYDKDGEWAASGKTDQQLLAQLLSHPYFSLAYPKSTGRELFNQAWLEQQLSQFNQLDEEDIQSTLLDLTCHSIARDILKLAPVGELFVCGGGAFNSELMQRLAALLPDYHIDTTSALGVDPKWAEGIAFAWLAMRHHLGLPANLPAVTGASREAVLGGRFSAK
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: PXR1_SCHPO
Sequence: MGLAGVKKKQQIGVDPRNSKWAKDTNRLGFKLLSSYGWVNGNGLGEKQHGRIHNIKVSLKDDTLGIGAKATNDLEWSGLGEFNAIFGRLNGDESAYGVYAEKAKVQQLTYERQSANEKGLKSLELSRRFVLGGTFTSEFSEWMQKAEEDEDRVCEDASSSDEAKREKRKKHSSKKKSKKKTSTGSALDPKKLEKITKKKKKEHKKKDKESSSKKRKSGSSDKEEKKKKKIKLKDKPESTSSVEKVKEGNRPASIHFHTRRKFLAQKRAAVSDPVALREILGIKG
What is the function of this protein?
Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase.
What are the official names of this protein?
Protein pxr1, PinX1-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the PINX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ACLE_ASPOR
Sequence: MSKRIRLGIVGLSADPSHCTNYIHKIPLTTTPLKEKYEITAVSMSSPEKAEAAAIAHGLPRERGYHSVESLAKDPDVDLVVVSVKVPRRAELAMAAIEAGKDVYVEWPFASNLAAAEALAQRARERQVKSMVGLPTRLAPQVLKMKEILRSGSLGRILATNLLVTDDLFLKFHADKRHSHDKTNGANIVTIAGGHLLDAMAFLLGEFTTLHAHTSMLFPKPVLCDTDGNLKTGQFNDSPDTFTMHGKIGISEVPVSVCMYSHPPTTPNLFQWVITGEKGSLKMEGPSLMIHAIPPKLMMTSFGSETVCWEEISLENTIVSGAEYQAWLDNDTERIVTLDEAVVRYRMVDAILRSAESGQCTSYRYD
What is the function of this protein?
Dehydrogenase; part of the gene cluster that mediates the biosynthesis of aspirochlorine (or antibiotic A30641), an unusual halogenated spiro compound with distinctive antifungal properties due to selective inhibition of protein biosynthesis, and which is also active against bacteria, viruses, and murine tumor cells (PubMed:25302411).  The non-ribosomal peptide synthetase (NRPS) aclP is responsible the formation of the diketopiperazine (DKP) core from the condensation of 2 phenylalanine residues (PubMed:25302411).  One Phe residue is tailored into chlorotyrosine by hydroxylation and chlorination, whereas the second Phe undergoes an unprecedented C-C bond cleavage to be converted into glycine (PubMed:25302411).  After formation of the DKP, sulfur is incorporated into the DKP by conjugation with glutathione by aclG, followed by its stepwise degradation to the thiol by aclI, aclJ and aclK, and the dithiol oxidation by aclT (PubMed:25302411).  In addition, oxygenases (aclB, aclC, aclL and aclO) and O-methyltransferases (aclM and aclU) act as tailoring enzymes to produce the intermediate dechloroaspirochlorine (PubMed:25302411).  Ultimately, chlorination of dechloroaspirochlorine by the halogenase aclH is the last step in the aspirochlorine pathway (PubMed:25302411).
What are the official names of this protein?
Dehydrogenase aclE, Aspirochlorine biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: BABA2_CHICK
Sequence: MSPEVALNRISPALSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPSCDRFKLHIPYAGETLKWDIIFNAHYPDLPPDFIFGEDAEFLPDPSALHNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDAEATQVFPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCQLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLYFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.  The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.  May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins.  May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.  May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
What are the official names of this protein?
BRISC and BRCA1-A complex member 2, BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, Brain and reproductive organ-expressed protein.
What is the protein family that this protein belongs to?
Belongs to the BABAM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: NSRR_SERP5
Sequence: MQLTSFTDYGLRALIYMASLPPDKMTSISEVTEVYGVSRNHMVKIINQLSRVGFVTAVRGKNGGIRLGKPAETIRLGDVVRALEPLSLVNCNSTFCHITPACRLKQVLQQGVQNFLEELDSHTLADMVEDNPSLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: GLRX1_CAMPM
Sequence: MAEEFVQQRLANNKVTIFVKFTCPFCRNALDILNKFSFKRGAYEIVDIKEFKPENELRDYFEQITGGRTVPRIFFGKTSIGGYSDMLEIDNMDALGDILSSIGVLRTC
What is the function of this protein?
Has thioltransferase and dehydroascorbate reductase activities.
What are the official names of this protein?
Glutaredoxin-1.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: TPIS_PSYWF
Sequence: MKSWVIGNWKLNPTSLEQVQHLVTDLVEGVDAQTRSMDNCHLMLAPSFLHLSPVQQALNANSSTLKLAAQDVSALSAESGAYTGDVSAKQLKDMGVQWVIVGHSERRQYYKESNAVLLKKLLNSAEQGLGVILCIGESESDFEAGHTEQVLDEELQVIADFLQQLKPEQAGYAEQNLIIAYEPVWAIGTGKVPSVEQVTQIHRFIRQQLHSFDNKLDTTPVIYGGSVKPENAADFAASDQINGVLVGGAALQADSFLAIAKCFNN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: US08_HCMVM
Sequence: MRRWLRLLVGLGCCWVTLAHAGNPYEDDDYYYYREDEPRQHGEPNYVAPPARQFRFPPLNNVSSYQASCVVKDGVLDAVWRVQGTFYPEKGIVARVGWSGRRGRKWGRLHAPECLVETTEAVFRLRQWVPTDLDHLTLHLVPCTKCKPMWCQPRYHIRYFSYGNSVDNLRRLHYEYRHLELGVVIAIQMAMVLLLGYVLARTVYRVSSAYYLRWHACVPQKCEKSLC
What are the official names of this protein?
Membrane glycoprotein US8.
What is the protein family that this protein belongs to?
Belongs to the cytomegalovirus US6 family.
What are the subcellular locations of this protein?
Host endoplasmic reticulum membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein.
Protein: LMIP_LOCMI
Sequence: AWQDLNAGW
What is the function of this protein?
Suppresses spontaneous contractions of the hindgut and oviduct.
What are the official names of this protein?
Locustamyoinhibiting peptide, LOM-MIP.
Protein: BR1EC_PELRI
Sequence: FLPLLAGLAANFFPKIFCKITRKC
What is the function of this protein?
Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
What are the official names of this protein?
Brevinin-1Ecb.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: OTCC_PSEPU
Sequence: MAFNIHNRNLLSLEHHTNRELRYLLDLTRDLKAK
What are the official names of this protein?
Ornithine carbamoyltransferase, catabolic, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.