PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_LIGS1
Sequence: MSQKDIEMELKELRNKLNRWSNEYYVLDTPSVEDSVYDKHYQRLLELEQANPDLVTADSPSQRVGGKVLSGFTKVSHDIPMLSLGDVFSKEELIEFLERLENSVEQKLDYSCELKIDGLAISLTYENGKFIKGSTRGNGVIGEDITENLKTIKAIPMELNEPVSIEVRGECYMPKKSFVELNTKREAEGQAVFANPRNAAAGSLRQLDTKITASRNLSTFIYYLMEPEKLGIKTQTEALNKLESWGFKVNNESKQVKTKEEIFAYIDKATDQRANLPYDIDGIVLKAESFAVQSQVGNTVKVPRWAIAYKFPPDEQETKVLDIEWTVGRTGVVTPTAVMEPVTLAGTTVARASLHNPDYLKEKDIRIGDTVKLHKAGDIIPEISEVVLAKRTEDSVEYQIPTECPECGAKLVHLDDEVALRCINPQCPALVKESLTHFASRNAMDIRGLGPRIIEQLYNREMIKDVAGIYSLTFEQLITLDKFKEKSANNLLTAIDNSRNNSIERLIFGLGIRHVGAKVARILAENYKSMDNLAKAKSDEISTIDSLGKIIGDSVEMYFADEHVMELLDELRQAGVNLEFLGKTREEQLESSTDSSFNGLRVVLTGTLDTLKRSEAKSWLEAHGAKVTGSVSKKTDLLIAGHDAGSKLTKAQELNVRVMNEAEFIQQMEEES
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: VNBP_SHVX
Sequence: MHPHDLNLLCCLHFSKPSLPNDLKTLLFRACETSCKLNRRLLDNKPFQGTSKCAKRRRAKRYNRCFDCGAYLYDDHVCKRFTSRSNSDCLSVIHQGPAKLYAEGAYRANSDAEQLIMNDMLLIKSLKL
What is the function of this protein?
May act as a regulatory factor during viral transcription.
What are the official names of this protein?
14.7 kDa protein, Putative nucleic acid-binding protein.
Protein: CYSD_SHEPC
Sequence: MAGRELSHLQQLEAESIQIIREVAAEFDNPVMLYSIGKDSSVMLHLARKAFYPGKIPFPLLHVDTGWKFKEMIAFRDTQAKKFGFELLTHINPEGLAQGINPFDHGSAKHTDIMKTQGLKQALNQYGFDAAFGGARRDEEKSRAKERVYSFRDRHHRWDPKNQRPELWRTYNGAVNKGESIRVFPLSNWTELDIWQYIYQENIELVPLYFAAKRKVVERGGQLIMADDERMQLAEGEQIKEEVVRFRTLGCYPLTAAMHSEADSLEKIIEEMLLTRSSERQGRLIDSDQSASMEQKKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: EFTS_SACEN
Sequence: MANYSAADVKRLRELTGAGMMDCKKALEATEGDFDKAVENLRIKGAKDVGKRAERATAEGLVAADNGVLVELNSETDFVAKNDEFIELANKVVAAVKAAGARDLEGALAASLDGKTVGEVVQELSAKIGEKLELRRVATFDGKVATYLHRRSADLPPAVGVLVEYTGDSEEAARGAAMQVAALKPKYLNRDEVPADIVADERRIAEETARAEGKPEKALEKIVEGRLNGFYKDNVLLDQPSVQDSKKTVKALLDEAGVTVTGFARFEVGQA
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CZS12_CRUCA
Sequence: MAFLKKSLFLVLFLGLVSLSICEEEKREEENEEVQEDDDQSEEKRGFLDVVKHVGKAVGKAALNAVNDLVNQGEQ
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Cruzioseptin-12, CZS-12.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Cruzioseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GAUT7_ARATH
Sequence: MKGGGGGGGGGGGGKRRWKVLVIGVLVLVILSMLVPLAFLLGLHNGFHSPGFVTVQPASSFESFTRINATKHTQRDVSERVDEVLQKINPVLPKKSDINVGSRDVNATSGTDSKKRGLPVSPTVVANPSPANKTKSEASYTGVQRKIVSGDETWRTCEVKYGSYCLWREENKEPMKDAKVKQMKDQLFVARAYYPSIAKMPSQSKLTRDMKQNIQEFERILSESSQDADLPPQVDKKLQKMEAVIAKAKSFPVDCNNVDKKLRQILDLTEDEASFHMKQSVFLYQLAVQTMPKSLHCLSMRLTVEHFKSDSLEDPISEKFSDPSLLHFVIISDNILASSVVINSTVVHARDSKNFVFHVLTDEQNYFAMKQWFIRNPCKQSTVQVLNIEKLELDDSDMKLSLSAEFRVSFPSGDLLASQQNRTHYLSLFSQSHYLLPKLFDKLEKVVILDDDVVVQRDLSPLWDLDMEGKVNGAVKSCTVRLGQLRSLKRGNFDTNACLWMSGLNVVDLARWRALGVSETYQKYYKEMSSGDESSEAIALQASLLTFQDQVYALDDKWALSGLGYDYYINAQAIKNAAILHYNGNMKPWLELGIPNYKNYWRRHLSREDRFLSDCNVNP
What is the function of this protein?
May be involved in pectin biosynthesis.
What are the official names of this protein?
Probable galacturonosyltransferase 7, Like glycosyl transferase 7.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: IF1A_METM7
Sequence: MRGQQAPPQQPTRVRTPRENENEVLGVIEQMLGASRVRVRCMDGKLRMGRIPGKLKRKIWVREDDVVIVTPWEVQSDEKCDVIWRYTKGQVDWLNKKGYLDFMR
What is the function of this protein?
Seems to be required for maximal rate of protein biosynthesis.  Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
What are the official names of this protein?
Translation initiation factor 1A, aIF-1A.
What is the protein family that this protein belongs to?
Belongs to the eIF-1A family.
Protein: RNSA_KITAU
Sequence: DVSGTVCLSALPPEATDTLNLIASDGPFPYSQDGVVFQNRESVLPTQSYGYYHEYTVITPGARTRGTRRIITGEATQEDYYTGDHYATFSLIDQTC
What are the official names of this protein?
Guanyl-specific ribonuclease Sa, RNase Sa.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease N1/T1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: SO2B1_HUMAN
Sequence: MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMAIFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV
What is the function of this protein?
Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1.
What are the official names of this protein?
Solute carrier organic anion transporter family member 2B1, Organic anion transporter B, OATP-B, Organic anion transporter polypeptide-related protein 2, OATP-RP2, OATPRP2, Organic anion transporting polypeptide 2B1, OATP2B1, Solute carrier family 21 member 9.
What is the protein family that this protein belongs to?
Belongs to the organo anion transporter (TC 2.A.60) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GCNT1_MOUSE
Sequence: MLRNLFRRRLFSCPTKYYFMLLVLSLITFSVLRIHQKPEFFSVRHLELAGDDPYSNVNCTKILQGDPEEIQKVKLEILTVQFKKRPRRTPHDYINMTRDCASFIRTRKYIVEPLTKEEVGFPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVDRKAEESFLAAVQGIASCFDNVFVASQLESVVYASWSRVKADLNCMKDLYRMNANWKYLINLCGMDFPIKTNLEIVRKLKCSTGENNLETEKMPPNKEERWKKRYTVVDGKLTNTGIVKAPPPLKTPLFSGSAYFVVTREYVGYVLENENIQKLMEWAQDTYSPDEFLWATIQRIPEVPGSFPSSNKYDLSDMNAIARFVKWQYFEGHVSNGAPYPPCSGVHVRSVCVFGAGDLSWMLRQHHLFANKFDMDVDPFAIQCLDEHLRHKALENLEH
What is the function of this protein?
Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan.  The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (PubMed:9881978, PubMed:12954635, PubMed:22056345).  Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (PubMed:9881978).  Can also act on glycolipid substrates.  Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (PubMed:7983056).  Can use Galbeta1-3GalNAcalpha1-R and Galbeta1-3GalNAcbeta1-R oligosaccharide derivatives as acceptor substrates (PubMed:7983056).
What are the official names of this protein?
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase, Core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GlcNAcT, Core 2-branching enzyme, Core2-GlcNAc-transferase, C2GNT, Leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GnT-L.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 14 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein. Note=Also detected in the trans-Golgi network.
Protein: YQ9A_SCHPO
Sequence: MTFPNVKFIGNKRVLSIQSSVSHGYVGNRSATFPLQLHEWEVDVVPTVHFSNHLGYGATRGSACIPEEVHDLLNALLQDNGIVYDAILTGFVPNHDIIQVIFDCVLAYKKDHPKVLWLLDPVMGDQGKMYVDTNVISTYKAMIPHAFAITPNAFEVEILTDIVIHTQMDAKRGLEKIYQLYGIQNAIITSFEVEESPGTLFCMGYSCEHGKPQLFLYQFPSLSGVFTGTGDLFSGLLLAKYREELDKRKHQQSDETKQTKRPTVLACAVGQVLSCMHTVLVNTKTYADEILLEDPKIASDEFLLSNARELRLIQSRTALLSKKSIYEAEFLPGFEEGEDV
What is the function of this protein?
Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
What are the official names of this protein?
Putative pyridoxal kinase C18.10.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EX7L_LACP3
Sequence: MVDASQYLSVTALTQYLKRKFDADPYLAKVYLTGEISNYRKRVGNQYFSLKDDHAKIGALMFRNAFSKVQFDLEEGMKVLVVGRVSLYEPSGEYRLIVEHLEPDGVGALYQAFEQLKKKLAAEGLFDRNQRPLPLFPKRVAVVTSPSGAVIQDIMTTVARRYPILQLTLFPAVVQGDQAADSLVKRLNQIKTIGGFDAVIIGRGGGSIEDLWPFNEEKVARALVDMPMPVVSSVGHETDTTITDFIADRRAATPTAAAEIVTPVTLIDALNRISEDRVRLVNAMHNRLKNAAIRVQRSAQSVVLTQPDRLYDQYVQRVDQFQQRLQQSMHNRLRDADHRLAMATSQLDGRQLFIRLVNLQRQVTGDRHRLDQAMRGLVKTKRQAFASAVSGLDHLSPLKILGRGFAYVTDKQGQMLKSLSDYELDQDIHIHVADGQVGAHVTTKEKTHG
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_HAEDU
Sequence: MAKITGNLVATGLKFSIVTARFNDFINDKLLSGAVDTLVRHGAVESDIDTVWVPGAFEIPLVAKKMAESGKYDAVICLGTVIRGSTTHYDYVCNEVAKGIGAVALQTGVPIMFGVLTTESIEQAIERAGTKAGNKGAECALGAIEMVNVLKAL
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: MON1_PHANO
Sequence: MAPLRGPTRASTSGISSQSREGTPPPLPPRPQLGNLPSRPSTSYSIRKAPSRPQLVSKATTQLSLSTGQAFGTESRDDAASIATKQRSFLGANLHSHSTSDADDSASIRSYMPGTEGVGEGESILGEVLGHEQKTDTEKTLLRSLGHKFGDGEAQSMFPPDPQFDAAFNREFDEVDEMSVDGSNEEAVMRQWRAKLKHFLILSSAGKPIYSRHGDDQLITNYIGVVQTIISFYQSTNDVLRGFTAGDVRFVVMSKGPLNLVAITRLPESDSQLRTQLEALYMQILSTLTLPSLERMFAARANYDLRRPLQGTDTLLSALADGFTRGSSSTLLSALECLKLRKSHRTTINNTLLKTRSENLLYGLIVASGKLVSVVRPKKHSLHPGDLHLIFNMLFEAGSVKAGGGENWIPLCLPGFNNTGYLYMYVSFLNLEHPTEQMQERPSTSEGAPDEVAILLISAEKESFFELRSMRDDLVETLQRNGSIEAMRAAVRQGRPKCTDIVPGSPLRHFLYKSRGNVQFTMPSFEPYFENALDKRRLLNLYNKLHSNVHNKPTTLKVHHETGTSCIALAWSTPLFELYAVAPAATSRAALAQSANKIIQTKLPSREKMNSFYGTLRLLSREFAPCPLPRSSHTESCKWQLNVRHIHANQYLSNWNAAGAQTFSHQSPTQSPWVCIDWIGRYLDEARSKVTQSATMPSGPLGRRVISPDEVRLYPHSCVQEA
What is the function of this protein?
Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
What are the official names of this protein?
Vacuolar fusion protein MON1.
What is the protein family that this protein belongs to?
Belongs to the MON1/SAND family.
What are the subcellular locations of this protein?
Endosome, multivesicular body membrane; Peripheral membrane protein. Prevacuolar compartment membrane; Peripheral membrane protein. Vacuole membrane; Peripheral membrane protein.
Protein: SYT_PELUB
Sequence: MPLITLPDGNTIEFPNKVTGLEVAEKISKSLSKQATIISVNEELKDLSFVLDKDCSVKIFTSKDKEGLETIRHDTAHITAMAVQELFPGTQVTIGPIIENGFYYDFSRKEPFTEDDLNKIENKMKEIVDRDVPTTREVWKRDKAISHFKDKGEIYKAEIIESIPQGEDVSIYFHGDWHDLCRGPHLSSTGKIGKYFKLTKVSGAYWRGDSNNEMLQRIYGTSWASQKDLDEYLKRIEEAEKRDHRKLGKEMDLFHFREESPGSVFWHEKGWKLFQKLVAYMRARQEKAGYKEVNTPEILDRSLWEKSGHWEKYGEHMYTSQTPDEKIFAIKPMNCPGHVQVFNQGLKSYRDLPLRISEFGKVHRYEPSGALHGLLRVRAFTQDDAHIFCTEDQITSECLIVTNLILDIYKDLGFEDVILKYSDRPDLRVGDDNVWDKAEKALLDAVKASKLQYTINKGEGAFYGPKIEFVLRDAIGRDWQCGTLQVDLNLPGRLDASFVDKDGTKKIPVMLHRALFGSLERFIGILIENYAGKFPFWIAPLQVVVIPISEEFDSYAKEVNEKINNAGISSEVDLKNHNLNYKIREHSLSKIPLLLICGKKEVDSNSVTIRRLDTNKQENMELNLFLETFSALNKASSN
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_POLNS
Sequence: MNLRPLHDRVIIKRLDQESKTASGIIIPDAAAEKPDQGEVLAVGPGKRDDGGKLNAPDVKVGDRVLFGKYAGQTVKVDSEELIVMREDDIMAVVQK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_PROM2
Sequence: MTSSKNPTNDNSYFDAVLVGGGIMSSTLALLISEVLPDIKFLIIEKLNAPGSESTGAFNNAGTGHAANCELNYTPLDEKGNLKIDKALSINRSFETSMSLWASLYEAGKIDIKKFLKFIPHISFVSGQDNISFLKKRFQKMTENPEFIDMEFSTSFDEISSWAPLITKDRNPSTQIAATRIGRGTDINFEALTKEYLSLVSLNKNVEIRYKTELIDLMKIDKKQWELEISSEGRKTSIRTGYVFLGAGGKTINYLQKSKIPEAKSYGGFPVSGKWLICEKKDLTEKHNSKVYGKADIGSPPMSVPHLDTRWIDNKKLLLYGPFAGFTTKFLKQSSYFDLFSSIKKNNIFSMLDVGFKNNDLINYLISQSLKSHNSRVENLKNMMPSANPSDWYLKNAGQRVQIIKKTEGGGSLKFGTEIVNSSDGSLSALLGASPGASTAVSIMVEVLEKSVLFLNDKHNLKKKINDLIYPERTASQKNSTFIKEIKKRNNSIFGFHP
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: RS17_ACET2
Sequence: MAERGLRKVRVGKVTSDKMDKTVVVSIETSEKHPLYKKFVKRTYKLKAHDENNECKIGDIVKVMETRPLSKEKRWRVVEIIERAR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: ABCG2_BOVIN
Sequence: MSSNSYEVSIPMSKKLNGIPETTSKDLQTLTEGAVLSFHNICYRVKVKTGFLLCRKTIEKEILANINGVMKPGLNAILGPTGGGKSSLLDILAARKDPHGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLPTTMTSYEKNERINKVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIAMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFGAIGFRCEPYNNPADFFLDIINGDSSAVVLNREDIGDEANETEEPSKKDTPLIEKLAEFYVNSSFFKETKVELDKFSGDQRRKKLPSYKEVTYATSFCHQLKWISRRSFKNLLGNPQASIAQLIVTVFLGLVIGAIFYDLKNDPAGIQNRAGVLFFLTTNQCFSSVSAVELLVVEKKLFIHEYISGYYRVSSYFFGKLLSDLLPMRMLPSIIFTCITYFLLGLKPKVEAFFIMMLTLMMVAYSASSMALAIAAGQSVVSIATLLMTISFVFMMIFSGLLVNLKTVVPWLSWLQYLSIPRYGYAALQHNEFLGQNFCPGLNVTTNNTCSYAICTGEEFLTNQGIDISPWGLWKNHVALACMIVIFLTIAYLKLLFLKKFS
What is the function of this protein?
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells.  Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme.  Also mediates the efflux of sphingosine-1-P from cells.  Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity).  In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity).  Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity).  Mediates the secretion of the riboflavin and biotin vitamins into milk.  Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity).  Plays an important role in the exclusion of xenobiotics from the brain.  It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (By similarity).  In placenta, it limits the penetration of drugs from the maternal plasma into the fetus.  May play a role in early stem cell self-renewal by blocking differentiation (By similarity).
What are the official names of this protein?
Broad substrate specificity ATP-binding cassette transporter ABCG2, ATP-binding cassette sub-family G member 2, Urate exporter.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein. Note=Enriched in membrane lipid rafts.
Protein: NMD3B_MOUSE
Sequence: MECVQTLWLSLALALARGSWVVRGHPQPCGVPTRAGASVRLAALLPRAPAARARVLAALATPSPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASITFPEARPELRLLQFLAAATETPVLSVLRREVRAPLGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPSGLVTLWTSRASQAPKFVLDLSQLDSGNDSLRATLALLGTLEGGGTPVSAAVLLGCSTAHAHEVLEAAPPGPQWLLGTPLPAEALPKTGLPPGVLVLGETGQPSLEAAVHDMVELVARALSSMALMHPERALLPAAVNCEDLKTGGSESTARTLARFLSNTSFQGRTGAVWVAGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHLSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQECSGPKEEQPAADGAGRWRRVRRAVVERERRVRFLLEPGEAGGDHPWLCSNGPGVQAELRELELRIEAARERLRSALLRRGELRAQLGDGTRLRPLRLLHAAPAES
What is the function of this protein?
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium.  Mediated by glycine.
What are the official names of this protein?
Glutamate receptor ionotropic, NMDA 3B, GluN3B, N-methyl-D-aspartate receptor subunit NR3B, NMDAR3B, NR3B, NMDA receptor 4, Nr4.
What is the protein family that this protein belongs to?
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane.
Protein: ARRD5_BOVIN
Sequence: MSVVKSIELVLPKDAVYLAGCIIEGQVVLTLNSTLVDPIVKVELVGRGYVEWNEETGASRDYSREVICNNKADYVHKTKTFPVEDNWLSAGSHTFDFHFNLPPRLPSTFTSKIGNIFYFVQASCMGREHILAKKKIYLMVQGTSSIFHSEKSLQNPLFVEAEKKVSYNCCSQGTICLQIQMEKNTFTPGERDIFTTEINNQTSKCIKTVIFALYAHVHYEGFTPNAERRSRVDSSELLRQEANTHITAFNTTKIVSTFHLPPVLSVSGSGSQDSEIMNTQYELVSTVHLPWTLTSVKAKVPIIITSNPVDSNQTAAGCRTRAPLPVSPDQQN
What are the official names of this protein?
Arrestin domain-containing protein 5.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: ACEK_PSEF5
Sequence: MSQSWPAADIARMILDGFDDYREHFRQITDGARQRFEQAQWQQAQKASAARINLYEEKVGETVARLHQAFSTESLMDVSQWPLVKSAYISLIDLRFDDELSETWYNSIFCGLFSHDLISDGCMFIHTTRPSLRRARAAQTRSYKPQGELATMLEQVFADYRFSEDYADLPGDLRRLEAQLRENLPDWVCKDPELTLELFSSVLYRNKGAYLVGRIFTHEEQWPLVIPLLHREGRGIQIDALITDEADVSIIFSFTRSYFMVDVPVPAEFIGFLKRILPGKHIAELYTSIGFYKHGKSEFYRALINHLASTDDRFIMAPGVRGMVMSVFTLPGFNTVFKIIKDRFSPSKNVDRATVIEKYRLVKSVDRVGRMADTQEFADFRFPLSKFDPACLEELLEVAPSTVAVEGQTVLIRHCWTERRMTPLNLYLEHANEAQVREALEDYGLAIKQLAAANIFPGDMLLKNFGVTRHGRVVFYDYDEICFLTEANFRHIPAPRTPEDEMASEPWYSIGPHDVFPEEFPPFLFADAGQRKLFDQLHGELYNADYWKGLQEAIRAGKVIDVFPYRRQGLEDE
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TYSY_NEIMB
Sequence: MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDEWADENGDLGPVYGYQWRNWPAPDGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFSFKFEDFELEGYDPHPHIKAAVSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HISX_PYRFU
Sequence: MDIEEYVREILKDIRERGLEAIREYSKKFDGYEGPFEVSKEEFKEAEERIPERDKEIIKRTLKRIEKYHRKQLKQDILYIENGSLYGLIYKPLKRIGIYVPGGKPLPSTLMMVGVPARVAGVKEIVVTNPPKDGKVNPYILYIAKLLKIEEVYKLGGIQAIAAMAYGIGMKKVQKIFGPGNKFVNEAKRQVFGIVGIDSLAGPSEIAVIADESADKDFVLYDLLSQLEHGKDSKAWLLTTSKELADYCNREGITVIVCSSLEECCKKANEIAPEHLEIITREPLKLVDLIENAGAIYLGLYTPVPAADYFLGVNHVLPTGGAAKFMGVLTVWDFMKPISIAMVSREEFISERELGIRLAEIEGIELHKKSLEVRK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.