PharMolix/UniProtQA huggingface dataset:
Protein: FUR_STAAW
Sequence: MNTNDAIKILKENGLKYTDKRKDMLDIFVEEDKYINAKYIQQVMDENYPGISFDTIYRNLHLFKDLGIIENTELDGEMKFRIACTNHHHHHFICEKCGDTKVIDYCPIDQIKLSLPGVNIHKHKLEVYGVCESCQD
What is the function of this protein?
Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
What are the official names of this protein?
Ferric uptake regulation protein, Ferric uptake regulator.
What is the protein family that this protein belongs to?
Belongs to the Fur family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL25_METPB
Sequence: MSATKTLEAVARDRVGKGAARAVRRQGQIPAVIYGGNQAPEAIAVDLIRTRTLIYAGGFKTTLFDITVGGKKTRAIPRDYQLDPVSGVPLHVDFLRVVSGQTVTVDVPVHFVNDEKAPGIKQKGGTLNVALHTVSLDVAPDQIPDAIEVDLTGREIGDVIHASDLRLPAGTYTGEPTDTVANILPPTVLGAEVEAEEAAIAEAQSAEAAEEKAEAEAEATNEKNDTEE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: NCBP1_DROYA
Sequence: MSRRRAHDTEDEGYDHRRNKRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLGTFRLKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKLCRWDAARYSLRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTLPWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLVFDSILCEALQHNLPAIVPPPHHDNFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHIIETYHHERKDCAAQLLSFPFKHKIPLEYCIVEVIFAELFHMPTPRYLDICYGSILIELCKLQPATLPQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFKFTWSWDEWDSCLLLDGEHPRPKFIQEVLQKCLRLSYHQRITEMMPTTYAKLIPLTPVPNYKYANEEAANLPGTTVAHQLVVAIRQKCTPEEVVNILKDIPSSGYSGEEMSDGSFNALKIDVFVQTLLNLGSKSFSHSFAAISKFHSVFRALAETEEAQICILHNIYELWSSHQQMMVVLIDKLLKLQIVDCSAVATWIFSKEMTGEFTKMYLWEILHLTIKKMNKHVIKLNSELSEAKDKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVERMEEKLEAANVNQKRLFLIVFQRFIMILSEHLLRSDTDGRDPDTDWYRWTIGRLQQVFLMHHEQVQKYSSTLETLLFTSDLDTHILEVFQQFVALRA
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of Cbp20 and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 1, 80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the NCBP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIPL2_BOVIN
Sequence: MEEPPLREEEEEEEEDEAGPEGALGKSPLQLTAEDVYDISYVMGRELMALGSDPRVTQLQFKIVRVLEMLETLVNEGNLTVEELRMERDNLRKEVEGLRREGSAAGPEVNLGPDKMVVDLTDPNRPRFTLQELRDVLQERNKLKSQLLVVQEELQCYKSGLIPPREGPGGRREKEALFPRGSNANSNKEEKTIIRKLFSFRSGKQT
What is the function of this protein?
Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines.  Plays a role in cellular protein transport, including protein transport away from primary cilia.  May function via activation of RAC1 and PAK1 (By similarity).
What are the official names of this protein?
RILP-like protein 2, Rab-interacting lysosomal-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the RILPL family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.
Protein: NTP1_CAEEL
Sequence: MRWRYTIRDQSPFEESSNCHRLTSSETANTFRWPMRTYNVYGFLLTCTCLLLILTIIPMSGGSSERVQRSVRSVVETKNNIKYGVICDAGSSGTRLFVYTLKPLSGGLTNIDTLIHESEPVVKKVTPGLSSFGDKPEQVVEYLTPLLRFAEEHIPYEQLGETDLLIFATAGMRLLPEAQKDAIIKNLQNGLKSVTALRVSDSNIRIIDGAWEGIYSWIAVNYILGRFDKENDSKVGMIDMGGASVQIAFEIANEKESYNGGNVYEINLGSIETNEDYKYKIYSTTFLGYGANEGLKKYENSLVKSGNSNDSCSPRGLNRLIGEFTVNGTGEWDVCLAQVSSLIGDKAQPSCPNPTCFLRNVIAPSVNLSTVQLYGFSEYWYTTSNFGSGGEYHYQKFTDEVRKYCQKDWNDIQDGFKRNEFPNADIERLGTNCFKAAWVTSVLHDGFNVDKTKHLFQSVLKIAGEEMQWALGAMLYHSKDLKFNLLEQLEVAQSTQQISNFFSFFVILIIVLAVALYRQLQSESTYKKYNFLRTDSKPDFLNV
What is the function of this protein?
Seems to be able to hydrolyze CTP, ATP and UTP.
What are the official names of this protein?
Nucleoside-triphosphatase ntp-1.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: PUR9_STAAM
Sequence: MKKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAIENIDIGGPTMLRAAAKNYKHVTTIVHPADYHEVLTRLRNDSLDESYRQSLMIKVFEHTAEYDEAIVRFFKGDKETLRYGENPQQSAYFVRTSNAKHTIAGAKQLHGKQLSYNNIKDADATLALVKKFDTPAAVAVKHMNPCGVGIGDTIEQAFQHAYEADSQSIFGGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKKNVRLLEIDMTIDSNEEEFVSVSGGYLVQDKDNYVVPKEEMKVVTEVAPTDEQWEAMLLGWKVVPSVKSNAIILSNNKQTVGIGAGQMNRVGAAKIALERAIEINDHVALVSDGFFPMGDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKHGIAMVVTGTRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: DIAC_RAT
Sequence: MALSDLLELTLLLLLPLLERLSAEDCPCSEASLCRPIRHHRDFEVFVFDVGQKTWKSYDWSQITTVAVFGKYDSELMCYAHSKGARVVLKGDVALKDIINPTFRASWIAQKVALAKAQHMDGINIDIEQEVDCSSPEYEALTALVRETTEGFHREIEGSQVTFDVAWSPKGIDKRCYNYTGIADACDFLFVMSYDEQSQIWSECIAAANAPYNQTLTGYGDYLRMGISPRKLVMGIPWYGYDYICLNLSKDDVCAIAKVPFRGAPCSDAAGHQVPYRVIMKQVNSSVSGSQWNQDQQAPYYNYKDPTGRLHQVWYDNPRSISLKAAFVKHYGLRGIGMWNANCLDYSDDALAREQTEEMWGALRPRL
What is the function of this protein?
Involved in the degradation of asparagine-linked glycoproteins.  Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase.
What are the official names of this protein?
Di-N-acetylchitobiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 18 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: SPEE_SALHS
Sequence: MAENTMWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVETITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFTLVIDDGVNFVNQTHQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQDEALDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSSEIIQARFHAAGLKCRYYNPAIHAAAFALPQYLHDALSAQ
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIOX2_HUMAN
Sequence: MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTAKEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVYIYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKESLVLSLWTECLIQVV
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.  Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression.  Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'.  May play an important role in cell growth and survival.  May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.
What are the official names of this protein?
Ribosomal oxygenase 2, 60S ribosomal protein L27a histidine hydroxylase, Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA, Histone lysine demethylase MINA, MYC-induced nuclear antigen, Mineral dust-induced gene protein, Nucleolar protein 52, Ribosomal oxygenase MINA, ROX.
What is the protein family that this protein belongs to?
Belongs to the ROX family. MINA53 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: FER2_SULTO
Sequence: MGIDPNYRQNRQVVGEHEGHKIYGPVEPPGKLGIHGTIVGVDFDVCIADGSCINACPVNVFQWFDTPGHPASEKKADPINEKACIFCMACVNVCPVAAIDVKPP
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Zinc-containing ferredoxin-2.
Protein: RS9_ECOL5
Sequence: MAENQYYGTGRRKSSAARVFIKPGNGKIVINQRSLEQYFGRETARMVVRQPLELVDMVEKLDLYITVKGGGISGQAGAIRHGITRALMEYDESLRSELRKAGFVTRDARQVERKKVGLRKARRRPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: Y600_MYCGA
Sequence: MNFQNLANQMKKMQREMEKKLAEFEEKEYQYEYKKLIKTTLKGNLRIVKLEINKDLIDPEDPDTLQDMVTEAINEALGDLEKKRDELSNSITPPIKFPGF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein MYCGA6000.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: TRUB_CHLTE
Sequence: MIDQGRISVLSEEGDYLLVDKPLDWTSFDVVAKIRGAYKRNGAKRKVGHCGTLDPKATGLLILATGRKTKTISSLELLDKAYEGTIRLGAKTVSHDTESEEYDLRDVPSLDERAIREAATSMIGERMQQPPMHSAVWHNGKRLYELARQGHEVKERKARQIEIHQFEITGIELPYVHFYIRVSKGAYIRVIAHELGELLGVGGYLKSLKRVAIGQYQLSDAMSVDAVVDEITRAASVIEE
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: HIR1_ASPTN
Sequence: MHIIKPVWLTHGGKLVVHDSSSSWHGPLTPTLLSTGERKDFEVYSCDVSPDGSRLVTAAGDGYVRIWSTEAIRNTDDSSQKPKQLASMSNHSGTIHTVRFSPNGKYLASGADDKIVCIYTLDANPPSHSTFGWSYDSSILVSVGLDSKVVVWSGHTFEKLKTLSVHQSHVKGITFDPANKYFATASDDRTVKIFRFTSPAPNSTAHDQMNNFVLETTISAPFQNSPLTAYFRRCSWSPDGMHIAAANAVNGPVSSVAIINRGSWDGDINLIGHEAPVEVCAFSPRLYSTQPPNKQTPDNQGQAVTVIACAGGDKSLSIWITTNPRPIVVAQELAAKSISDLAWSPDGTCLYATALDGTILAVRFEDGDLGYPMAMEENEKSLTKFGTNRRGAGITETTDGLLLEEKSKAGELKGVEGRMGALMGDGHASAEATVNGKALSSNGAAPAQGTSPTADAQKTQTNGTTTPAAQEADKPDPYQAKLERLKQRPTYTKDGKKRIAPLLVSGAGAAESSLPQARLMASVSSQVKADTPQSIVDLSKPFDGLPKGGLAALLFGNKRKLAQLEGDEDGHVEKRVALASQNGATPIMANTPDGLLPAQPQPPATGQQQTPEYIRPAVTNPCMAISQLRLAVPKVRSQIVRAIDSTGKPTEPPGASSEANKSRVDLVFEARNPSPASLTGRAVDREPVRLTLFRGEQPLWQDFLPRTVLLVTGNQSMWAAACEDGSVYIWTPAGRRLVSALVLEAQPVILECNGPWILCISAVGMCYVWNVKHLSSPHPPISLQPVLDAAVHTLGAHPSSAPAITNARINSEGRVIVALSNGEGYAYSPSMYTWQRMSEAWWAVGSQYWNTTEAPVGNLQSTDSQDKDAKAAVSAGIIPFLERNTTNETLLRGRAYFLQRLIKVLLSREGYESFESSVSIAHLENRLAAALSLGAKEEFRLYLSMYAKRIGAEGLKNKVEELLKGLIGGKHRDLQRVTVPYAKLLGVVDESEAGDAMET
What is the function of this protein?
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
What are the official names of this protein?
Protein hir1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat HIR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PG176_VAR67
Sequence: MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDSIEIRGVLPEETNIGCTVNTPVSMTYLYNKYSFKLILAEYIRHRNTVSGNIYSALMTLDDLVIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDIICCDSRIVVALSSLVSKHWELTNKKYRCMALAEHIADSIPISELSRPRYNLCKYLRGHTESIEDEFDYFEDDDSSTCSVVTDRETDV
What is the function of this protein?
BCL2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation.  Acts close to the plasma membrane and targets several host TIR-domain containing adapter proteins including MYD88, TIRAP, TRIF and TICAM2.  In turn, blocks the host NF-kappa-B and TRIF-mediated IRF3 activation.
What are the official names of this protein?
Protein OPG176.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG176 family.
Protein: HEM3_HELPY
Sequence: MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGAIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQIKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAKYRKAFSVEEMIPSMGQGALGVEMLKNHKHFATLQKLNDEKSAFCCRLEREFIKGLNGGCQIPIGVHASLMGDRVKIQAVLGLPNGKEVITKEKQGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: LEPA_MYCBO
Sequence: MRTPCSQHRRDRPSAIGSQLPDADTLDTRQPPLQEIPISSFADKTFTAPAQIRNFCIIAHIDHGKSTLADRMLQLTGVVDERSMRAQYLDRMDIERERGITIKAQNVRLPWRVDKTDYVLHLIDTPGHVDFTYEVSRALEACEGAVLLVDAAQGIEAQTLANLYLALDRDLHIIPVLNKIDLPAADPDRYAAEMAHIIGCEPAEVLRVSGKTGEGVSDLLDEVVRQVPPPQGDAEAPTRAMIFDSVYDIYRGVVTYVRVVDGKISPRERIMMMSTGATHELLEVGIVSPEPKPCEGLGVGEVGYLITGVKDVRQSKVGDTVTSLSRARGAAAEALTGYREPKPMVYSGLYPVDGSDYPNLRDALDKLQLNDAALTYEPETSVALGFGFRCGFLGLLHMEITRERLEREFGLDLISTSPNVVYRVHKDDGTEIRVTNPSDWPEGKIRTVYEPVVKTTIIAPSEFIGTIMELCQSRRGELGGMDYLSPERVELRYTMPLGEIIFDFFDALKSRTRGYASLDYEEAGEQEAALVKVDILLQGEAVDAFSAIVHKDTAYAYGNKMTTKLKELIPRQQFEVPVQAAIGSKIIARENIRAIRKDVLSKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSTDAAGDKGKK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SAHH_NOSS1
Sequence: MTATSPRLKHEVKDLALAPLGRQRIEWAGREMPVLRQIRDRFAQEKPFAGLRLVACAHITTETAHLAIALKAGGADAVLIASNPLSTQDDVAASLVLDHEIPVFAQKGEDNATYNRHVQIALDHRPNIIIDDGSDVVATLVQERQHQIADLIGTTEETTTGIVRLRAMFKDGVLTFPAVNVNDADTKHFFDNRYGTGQSTLDGIIRATNILLAGKNVVVVGYGWCGKGTALRARGMGANVIVTEIDPIKAIEAVMDGFRVLPMAEAAPQGDIFITVTGNKHVVRGEHFDVMKDGAIVCNSGHFDLELDLKYLAANAKEIKEVRPFTEEYKLTNGKSVVVLGQGRLINLAAAEGHPSAVMDMSFANQALACEYLVKNKGKLAPGLHSIPVEVDQEIARLKLQAMGIYIDSLTPEQIEYINSWTSGT
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECD_ELUMP
Sequence: MSNKVLVKWAVILVALFASVYLLYPVYKWYSLSNEDRAKLEASGDRPKNILNLGLDLRGGSSLLLELDVTKLPDNTPAARNDAVSRAIEIIRNRIDQYGVAETPITRQGEKWISVQLPGIANPAQAEALIGKTAMLEFRIVKPQTSALDKAAAKIEDTEEPWDEDGNLIPSLAKLLPADTIVLKNKEGGFSFLEKEVKVTGADLENAQVNVGGDYGYPEVSFTFSAEGAKKFGSLTGSNIGKQLAIVLDNTVQSAPSIQSRITRDGRISGRFTMDEARRLAITLRAGALPAPVKIIEKRTIGPSLGEDSIKSGVRASLYGIVIILILMAIYYKSGGIISNIALILNLVFLLAAMAAFNATLTMPGIAGIILSLAMAIDANVLILERMREEKLRGRSLYEMIDLGYTKAWSAIFDSNFTSWIVALFLFQFGSGPVKGFAVTLTLGLLIGVFTSVFVTRAIYDLLLTANPKDISL
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecD.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecD subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MNHE2_STAA2
Sequence: MNQIVLNIIIAFLWVLFQDEDHFKFSTFFSGYLIGLIVIYILHRFFSDDFYVRKIWVAIKFLGVYLYQLITSSISTINYILFKTKDMNPGLLSYETRLTSDWAITFLTILIIITPGSTVIRISQDSKKFFIHSIDVSEKEKDSLLRSIKHYEDLILEVSR
What are the official names of this protein?
Putative antiporter subunit mnhE2, Mrp complex subunit E2, Putative NADH-ubiquinone oxidoreductase subunit mnhE2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VSWA_TRYBR
Sequence: MSVLFLLLAITRTASVKAAEGDQAADFLPLCEAWQATKALANAAYKLPPFPPDLTDILNFNITVAPEEWKAIFTDGGSDNTWERFAEGHKNTLNGGNWKTRWEHIKQARQDTKEASSPWNALNSKLINTATVNTTRAYIASIADEAFDLYQGTQTPLQTPKALEAASLAEAAKAILCSDPLKPTADGQACTDITATPSKAATCPTGRSSKGGAPIGLDTVCLCSTNKPSMHSRRRKAAAVMTDGQLKDGILKKLLAACPKKPTLNEPAAAARHAVTVLATRLAQKVARAEEGQIILGTRAETDCASSGSACVEYTNFFKDGDGLAAVPWVKKLLAAADFYDTIEKRKESDKNAATAIAALKSALIREFRRPGQEQTLATTGTKSSSPQSTQQKASEAEANCNDKAKETECNSPCKWDKEEKDEKKRCKLSEEGKQAEKENQEGKDGKANTTGSSNSFVIKTSPLLLAVLLL
What is the function of this protein?
VSG forms a coat on the surface of the parasite.  The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
What are the official names of this protein?
Variant surface glycoprotein WRATAT A, VSG.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Note=A soluble form is released from ruptured cells by the action of a PI-PLC.
Protein: VKT2_TROCA
Sequence: MSSGGLLLLLGLLTLWEILTPVSSKDHPEFCELPADSGPCRGILHAFYYHPVHRTCLEFIYGGCYGNANNFKTIDECKRTCAA
What is the function of this protein?
Serine protease inhibitor.
What are the official names of this protein?
Kunitz-type serine protease inhibitor carinatin-2.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: BICD2_HUMAN
Sequence: MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL
What is the function of this protein?
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin.  Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576).  Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form.  Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623).  Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1.  During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).
What are the official names of this protein?
Protein bicaudal D homolog 2, Bic-D 2.
What is the protein family that this protein belongs to?
Belongs to the BicD family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasm, cytoskeleton. Cytoplasm. Nucleus envelope. Nucleus, nuclear pore complex. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (PubMed:20386726).
Protein: IL1B_MOUSE
Sequence: MATVPELNCEMPPFDSDENDLFFEVDGPQKMKGCFQTFDLGCPDESIQLQISQQHINKSFRQAVSLIVAVEKLWQLPVSFPWTFQDEDMSTFFSFIFEEEPILCDSWDDDDNLLVCDVPIRQLHYRLRDEQQKSLVLSDPYELKALHLNGQNINQQVIFSMSFVQGEPSNDKIPVALGLKGKNLYLSCVMKDGTPTLQLESVDPKQYPKKKMEKRFVFNKIEVKSKVEFESAEFPNWYISTSQAEHKPVFLGNNSGQDIIDFTMESVSS
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.