PharMolix/UniProtQA huggingface dataset:
Protein: Y1120_ARCFU
Sequence: MRRWGMAKIAVVSLGGAGTSIMREMLGIASDFDAYNVNERRTLKNARYFGYEEMEALAEELSGYDCIIFTAGLGSRSGDALVDLYGMLDGVRRLCFLVTPFYFEIERLMRSRAQLGKIMTEDFEGAVLTLNSLLRDMEEAEPSKSKLEKLVRRFDREVASLIVEMMQEVR
What are the official names of this protein?
Uncharacterized protein AF_1120.
Protein: ISPD_ALKCK
Sequence: MEYAAIVLAAGQGKRMKAGMNKQLIDLNGIPLIVHSLRLFEEDAACKAIWLVVSETERQTMEKLVAEYQIGKVKGLVNGGAERQDSVYAGLKGMEEAEIVLIHDGARPFVAKPILTKLADEAAQSGAAIAAVPVKDTVKLADKNSVARTVERKNLWAAQTPQAFQYELVLAAHEDAKKHGFLGTDDASLVERLDKRVTIVESDYLNIKLTTEEDLLFAETILKKRENQL
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: DNAK_POLSJ
Sequence: MGRIIGIDLGTTNSCVSIMEGNTPRVIENSEGARTTPSIVAYQEDGEVLVGASAKRQAVTNAKNTLYAIKRLIGRKFTEKEVQKDINLMPYKIAAADNGDAWVEVRGKQISAQQVSADILRKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKQEKGDRKIAVYDLGGGTFDISIIEIADVDGEKQFEVLSTNGDTFLGGEDFDQRIIDYIIAEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSNSAQTDINLPYITADASGPKHLNIKLSRAKLEALVEELLERTLAPCRTAIKDAGVSVGDIHDVILVGGQTRMPKVQEMVKALFGKEPRKDVNPDEAVAVGAAIQGQVLSGDRTDVLLLDVTPLSLGIETMGGVMTKMIKKNTTIPTKFAQTFSTAEDNQPAVTIKVFQGEREIASGNKALGEFNLEGIPPAARGTPQIEVSFDIDANGILHVGAKDKGTGKENKITIKANSGLSEAEIQQMVKDAELHSADDKKKVEFVQAKNNAEAMVHSVRKSLGEYGDKLEVGEKEKIETAIKDMEEALKGDDKDAIEAKNTALMEASQKLGEKMYADMQSSQAAGAEAAAGGAGAEQAHAKPADDNVVDAEVKEVKKG
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: KTHY_SULAC
Sequence: MFIISFEGIDGSGKTTISKIIYEKLLIEIGSNKKIILTSEPFSQEIIKLIEEIGWKDPISLALLFTADRAYHLNLLFKQNPEIIIMDRYIDSTIAYQSSLGIDENWIRNLNKYFPEPDLTILLDLKPETAIARIKNKVDKFNFDEKISTLSKVREKYLELAKRNNKIRIVNAEKSIDEIVEETWSIVYSFLNHF
What are the official names of this protein?
Probable thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: PSBJ_SECCE
Sequence: MADTTGRIPLWLIGTVAGIAVIGLVGVFFYGSYSGLGSSL
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: PAP5_ARATH
Sequence: MALPWCLKTGVLTSPAAGFNHPSDSGFAVPTKLLSIRKGDRERLRIQAVFSFPPRNGGAEKRKQLKHELVEAIEPLERGATASPDDQLLIDQLARKVEAVNPTKEPLKSDLINGKWELIYTTSAAILQAKKPRFLRSLTNYQCINMDTLKVQRMETWPFYNSVTGDLTPLNSKTVAVKLQVFKILGFIPVKAPDGTARGELEITYVDEELRISRGKGNLLFILKMFDPTYRIPL
What are the official names of this protein?
Probable plastid-lipid-associated protein 5, chloroplastic, Fibrillin-3b.
What is the protein family that this protein belongs to?
Belongs to the PAP/fibrillin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid. Note=Located in thylakoid as a peripheral protein at the stromal side.
Protein: E75_CHOFU
Sequence: MTLVMSPDSSYGRYDAQPPVDGGMVNPVHREREPELHIEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSSSSRAHEQAAAAELDDAPRLLARVVRAHLDTCEFTRDRVAAMRARARDCPTYSQPTLACPLNPAPELQSEKEFSQRFAHVIRGVIDFAGLIPGFQLLTQDDKFTLLKSGLFDALFVRLICMFDAPLNSIICLNGQLMKRDSIQSGANARFLVDSTFKFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNIELVERMHARLKSCLQTVIAQNRADRPGFLRELMDTLPDLRTLSTLHTEKLVVFRTEHKELLRQQMWGDEEVCPWADSGVDDSARSPLGSVSSSESGEAPSDCGTPLLAATLAGRRRLDSRGSVDEEALGVAHLAHNGLTVTPVRPPPRYRKLDSPTDSGIESGNEKHERIVGPGSGCSSPRSSLEEHMEDRRPLAADDMPVLKRVLQAPPLYDASSLMDEAYKPHKKFRAMRRDTGEAEARPMRPTPSPQPMHPHPGSPAHPAHPAHSPRPLRAPLSSTHSVLAKSLMEGPRMTPEQLKRTDIIQQYMRRGEAGEECRAGLLLYRGASPLQVDVADAPQPLNLSKKSPSPPRSFMPPMLEA
What is the function of this protein?
Orphan receptor possibly involved in the regulation of genes in the ecdysteroid cascade.
What are the official names of this protein?
Ecdysone-inducible protein E75, Nuclear receptor subfamily 1 group D member 3.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS7_BACFN
Sequence: MKKKVLFIDRDGTLVIEPPVDYQLDSLEKLEFYPKVFRNLGFIRSKLDFEFVMVTNQDGLGTSSFPEETFWPAHNLMLKTLAGEGITFDDILIDRSMPEDCASTRKPRTGMLTKYISNPEYDLEGSFVIGDRPTDVELAKNIGCRAIYLQESIDLLKEKGLETYCALATTDWDRVAEFLFAGERRAEIRRTTKETDILVALNLDGKGTCDISTGLGFFDHMLEQIGKHSGMDLTIRVKGDLEVDEHHTIEDTAIALGECIYQALGSKRGIERYGYALPMDDCLCRVCLDFGGRPWLVWDAEFKREKIGEMPTEMFLHFFKSLSDAAKMNLNIKAEGQNEHHKIEGIFKALARALKMALKRDIYHFELPSSKGVL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_NEUCR
Sequence: MVRYAATEIAPAKSARSRGSYLRVSFKNTRETAQAINGWKLQRAQKFLENVLEKKEAVPMRRYAGGTGRAAQGKQFGVSRARWPAKSAEFLLGLLKNAEANADAKGLDTGNLVVKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEADEVVQKSEAVVREEAHLSSRQRGARVRRAITAA
What are the official names of this protein?
60S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RPOC2_SYNS9
Sequence: MTTSKPRKPSKAKAAKAAKAAKAALEKISKPLSKTPPPFRNHIIDKKALKNLVAWSFKHHGTAVTSSMADDLKDLGFKYATQAAVSISVDDLKVPAAKKDLLGQAEEQITATEERYRLGEITEVERHTKVIDTWTETNERLVDAVKKNFDENAPLNSVWMMANSGARGNMSQVRQLVGMRGLMANPQGEIIDLPIRTNFREGLTVTEYVISSYGARKGLVDTALRTADSGYLTRRLVDVAQDVIVREDDCGTMRHIVVEAEDSKFAKRLVGRLTAAQVVSAEGEVLAERDTEIDPALSSKIEKAGITAVSIRSPLTCEANRSVCRKCYGWALAHNELVDLGEAVGIIAAQSIGEPGTQLTMRTFHTGGVSTAESGVVRSKVAGDVEFGSKARVRPYRTPHGVEAQQAEVDFTLTIKPSGKGRPQKIDITLGSLLFVDNGQAIESDVTVVQIAAGAVQKSVEKATKDVICDLAGQVHYEDKIQPREVTDRQGNITLKAQRLGRMWVLAGDVYNLPPNALPVVDGKSTVTEGQVLAEASQRSEFGGDVRLRDSIGDSREVQIVTTAMTLKDFKLLEESNHSGELWNLEAKDGTRYRLNTIPGSKIGNGEVIAELADDRFRTGTGGLVKFAPGLAIKKARSAKNGYEVNKGGTLLWVPQETHEINKDISLLMITDGQWIEAGTEVVKDIFSQTAGVVTVTQKNDILREIIVRGGDLRLISDNKALERFEGDGQMVNPGDDVAKGVSVDTMKFVQTVETPEGKGLLLRPVEEYTIPNEAQLPELSHLKQANGPHLGIKATQRLAFKDNELIKSVEGVELLKTQLLLETFDTTPQMTVDVERAPDKRAKTISRLRLVILESILVRRDTMSDSSHGSTHTDLQVEDGISVKAGDVVATTQILCKQEGVVQLPEATEAEPVRRLIVERPEDTTTISTSGKPSVAVGDRVVDGDLLASGQPSDCCGEVEAVDGSSVTLRLGRPYMVSPDSLLHVRDGDLVQRGDGLALLVFERQKTGDIVQGLPRIEELLEARRPRDSAILCRKPGTVEIKQGEDDDSLSVNVIESDDAIGEYPILLGRNVMVNDGQQVTAGELLTDGPINPHELLECFFEDFRSRKPLMDAAQEAIANLQHRLVTEVQNVYKSQGVSIDDKHIEVIVRQMTSKVRVEDAGDTTLLPGELIELRQVEDTNQAMAITGGAPSEFTPVLLGITKASLNTDSFISAASFQETTRVLTEAAIEGKSDWLRGLKENVIIGRLIPAGTGFSGFEEELQKEAGPHPDILSEDPAGYRRMQNLRPDYTVDMPPAASSSALLADPSDADLEATRTRHNIDPSASTNAAFTRPDVDNELKEEQVVDAEAVEGLQEEGLLSDD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC2 subfamily.
Protein: ULAG_SALCH
Sequence: MSKVQSITRESWILSTFPEWGSWLNEEIEQEQVAPGTFAMWWLGCTGIWLKSEGGTNVCVDFWCGTGKQSHGNPLMKTGHQMQRMAGVKKLQPNLRTTPFVLDPFAIRQIDAVLATHDHNDHIDVNVAAAVMQNCADDVPFIGPQTCVDLWVGWGVPKERCIVVKPGDVVKVKDIEIHALDAFDRTALITLPADQKAAGVLPEGMDVRAVNYLFKTPGGNLYHSGDSHYSNYYAKHGNEHQIDVALGSYGENPRGITDKMTSADILRMAESLNTKVVIPFHHDIWSNFQADPQEIRVLWEMKKDRLKYGFKPFIWQVGGKFTWPLDKDNFEYHYPRGFDDCFTIEPDLPFKSFL
What is the function of this protein?
Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P.  Is essential for L-ascorbate utilization under anaerobic conditions.
What are the official names of this protein?
Probable L-ascorbate-6-phosphate lactonase UlaG, L-ascorbate utilization protein G.
What is the protein family that this protein belongs to?
Belongs to the UlaG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_RHOPB
Sequence: MTNGNGAPPEAAQAPQLNVLAQYTKDLSFENPNAPASLAPQAQQPSINIQINVTANTLADSEFEVTLAIEGKADNAGSLIFSFELLYAGVFRILNVPKENLHPLVMIECPRLLFPFAREIIATAVRDGGFPPLMLDPVDFVGLYRQNMERQAAAAASADEAKPS
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_BACC3
Sequence: MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQKTVKKVEEAFKVMRDIAAEGGDILFVGTKKQAQEAIKEEATRAGMYFVNQRWLGGTLTNFQTIQKRIKRLKDIERMQEDGTFEVLPKKEVVQLKKELERLEKFLGGIKDMKGLPSALFVVDPRKERIAVAEARKLHIPIIGIVDTNCDPDEIDHVIPANDDAIRAVKLLTSKMADAILEAKQGEETVTA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: RS15_SYNS3
Sequence: MSLDTTEKQQLINSHQTHATDTGSAEVQVAMLSERISKLSSHLQQNIHDYSSRQGLLKMIGRRKRLLGYVRGKSEQRYSDLISKLGIRG
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: RL36_STREM
Sequence: MKVRPSVKPICEYCKVIRRNGRVMVICPTNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: COPA2_ARATH
Sequence: MLTKFETKSNRVKGLSFHPKRPWILASLHSGVIQLWDYRMGTLIDRFDEHEGPVRGVHFHNSQPLFVSGGDDYKIKVWNYKTHRCLFTLLGHLDYIRTVQFHHENPWIVSASDDQTIRIWNWQSRTCISVLTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIGALKKKSASPADDLMRFSQMNSDLFGGVDAIVKYVLEGHDRGVNWASFHPTLPLIVSGADDRQVKLWRMNETKAWEVDTLRGHMNNVSSVMFHAKQDIIVSNSEDKSIRVWDATKRTGIQTFRREHDRFWILAVHPEINLLAAGHDNGMIVFKLERERPAFALSGDSLFYAKDRFLRYYEYSTQKDSQVIPIRRPGTPSLNQSPRTLSYSPTENAVLICSDLDGGSYELYIIPKDSVGRSDVVQDAKRGTGGSAVFIARNRFAVLEKSTSQVLVKNLKNEVVKKSSLPIPTDAIFYAGTGNLLCRSEDKVVIFDLQQRLVLGELQTPFVRYVVWSNDMESVALLSKHTIIIASKKLVLQCTLHETIRVKSGAWDDNGVFIYTTLNHIKYCLPNGDSGIIRTLDVPIYITKVSGNTIFCLDRDGKNRAITINATEYIFKLALLRKKYDHVMSMIKNSQLCGQAMIAYLQQKGFPEVALHFVEDERIRFNLALESGNISVAVASATEINEKDHWYRLGVEALRQGNSRIVEFAYQQTKNFERLSFLYLITGNLDKLSKLMKIAEVKNNVMGQFHNALYLGDVKERVKILENAGHLPLAYITASVHGLTDIAERLAIELGDNVPSLPEGKTPSLLMPPSPIMCGGDWPLLRVMKGIFEGGLESANRGAVDEEEEDVEGDWGEGLDKFDVDGMENTDIEAILDGAEAGEEEDDEEGGWGLDLDLPPELDTPKASANARSSTFVTPPQGMPVSQIWSQKSSLAAEQAAAGSFDTAMRLLHRQLGIKNFAPLKSMFLDLFSGSHSYLRAFSSSPVVPLAIERGWSESSSPNVRGPPALVFDFSQLEAKLKSGYKATTAGKLSEALRVFLSILQTIPLVVVESRREVDEVKELVIIVKEYVLGLQLELKRREMKDDPVRQQELAAYFTHCKLQTPHLRLAYFSAMTVCYKSKNMATAAHFARSLLDTNPTIESQARTARQVMQAAERNMTDATTLNYDFRNPFVICGSTYVPIYKGQKDVACPYCTARFVPSQEGNICSVCDLAVIGADASGLLCSASQVR
What is the function of this protein?
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.  Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).
What are the official names of this protein?
Coatomer subunit alpha-2, Alpha-coat protein 2, Alpha-COP 2.
What are the subcellular locations of this protein?
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Protein: LPCT4_MOUSE
Sequence: MSQGSPGAWAPLDPTSGSSASPNPFVHELHLSGLQRVKFCLLGVLLAPIRVLLAFIVLFLLWPFAWLQVAGLTEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLEAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYQPSLEESKDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGQLKVALEPQLWELAKVLQKAGLSPGFVDMGAEPGRSRMISQEAFAQQLQLSDPQTVAGAFSYFQQDAKGLVDFRNVALALAALDGGRSLEELTRLAFELFAEEQAEGSDRLLYKDGFSTILHLLLGSPRPAATTLHAELCQPGCSQGLSLCQFQNFSLHDPLYGKLFSAYLRPPHKPRSTSQIPNASSPSSPTALANGTVQAPKQKGD
What is the function of this protein?
Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively.  In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity.  Prefers long chain acyl-CoAs (C16, C18) as acyl donors (By similarity).  Converts lysophosphatidylcholine to phosphatidycholine (PubMed:18156367).
What are the official names of this protein?
Lysophospholipid acyltransferase LPCAT4, 1-acylglycerol-3-phosphate O-acyltransferase 7, 1-AGP acyltransferase 7, 1-AGPAT 7, 1-acylglycerophosphocholine O-acyltransferase, 1-acylglycerophosphoserine O-acyltransferase, 1-alkenylglycerophosphoethanolamine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acyltransferase-like 3, Lysophosphatidylcholine acyltransferase 4, Lysophosphatidylethanolamine acyltransferase 2, Plasmalogen synthase.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PEX19_HUMAN
Sequence: MAAAEEGCSVGAEADRELEELLESALDDFDKAKPSPAPPSTTTAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMTSQQEFTSCLKETLSGLAKNATDLQNSSMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGASGEQCLIM
What is the function of this protein?
Necessary for early peroxisomal biogenesis.  Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs).  Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3.  Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
What are the official names of this protein?
Peroxisomal biogenesis factor 19, 33 kDa housekeeping protein, Peroxin-19, Peroxisomal farnesylated protein.
What is the protein family that this protein belongs to?
Belongs to the peroxin-19 family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Lipid-anchor; Cytoplasmic side. Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes.
Protein: HIS6_PSYWF
Sequence: MLAKRIIPCLDVDNGRVVKGVQFVDIKDAGDPVEVARRYNEQGADEITFLDITATHHGRETTYDMVERIAETVFVPLTVGGGVRKIEDIRNLLNAGADKVAINSAAVFTPEFVAEAAAKFGSQCIVVAIDAKQVEDVEGQPRWEIFTHGGRKPTGLDAVAWAVKMAELGAGELLVTSMDGDGTKKGYDLALMKAITSAVNVPVIASGGVGNLQHLADGVLEGGADAVLAASIFHFGEYSIAEAKQFMAKQGIEMRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_ECO81
Sequence: MSKPIVMERGVKYRDADKMALIPVKNVATEREALLRKPEWMKIKLPADSTRIQGIKAAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVAPDANEPVKLAQTIADMALRYVVITSVDRDDLRDGGAQHFADCITAIREKSPQIKIETLVPDFRGRMDRALDILTATPPDVFNHNLENVPRIYRQVRPGADYNWSLKLLERFKEAHPEIPTKSGLMVGLGETNEEIIEVMRDLRRHGVTMLTLGQYLQPSRHHLPVQRYVSPDEFDEMKAEALAMGFTHAACGPFVRSSYHADLQAKGMEVK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCFT_ECOLI
Sequence: MKQKELWINQIKGLCICLVVIYHSVITFYPHLTTFQHPLSEVLSKCWIYFNLYLAPFRMPVFFFISGYLIRRYIDSVPWGNCLDKRIWNIFWVLALWGVVQWLALSALNQWLAPERDLSNASNAAYADSTGEFLHGMITASTSLWYLYALIVYFVVCKIFSRLALPLFALFVLLSVAVNFVPTPWWGMNSVIRNLPYYSLGAWFGATIMTCVKEVPLRRHLLMASLLTVLAVGAWLFTISLLLSLVSIVVIMKLFYQYEQRFGMRSTSLLNVIGSNTIAIYTTHRILVEIFSLTLLAQMNAARWSPQVELTLLLVYPFVSLFICTVAGLLVRKLSQRAFSDLLFSPPSLPAAVSYSR
What are the official names of this protein?
Inner membrane protein YcfT.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PGK_CHLTB
Sequence: MDKLSIRDLSLEGKKVLVRVDFNVPIKDGKILDDVRIRSAMPTIHYLLKQDAAVILVSHLGRPKGGVFEEAYSLAPIVPVLEGYLGHHVPLSPDCIGEVARQAVAQLSPGRVLLLENVRFHKGEEHPDEDPSFAIELAAYADFYVNDAFGTSHRKHASVYRVPQLFPDRAAAGFLMEKELEFLGQHLLVEPKRPFTAILGGAKMSSKIGVIEALLSCVDHLVLAGGMGYTFLRAMNRQVGNSLVEESGIPLAKKVLEKAQALGVKIHLPVDAKVAKQCDSGEDWRELSIQEGIPEGLAGFDIGAQTIELFSKVIQESATIFWNGPVGVYEVPPFDQGSKAIAQCLASHSSAVTVVGGGDAAAVVALAGCTSQISHVSTGGGASLEFLEKGSLPGTEILSPAQS
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_PROMP
Sequence: MSQEEILQKVCSIVSEQLSVESAEVKSDSNFQNDLGADSLDTVELVMALEEAFDIEIPDEAAEGIATVGDAVKFIEEKKG
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_YERPG
Sequence: MSSLSKEAELVHQALLARGLETPLRKPELDAETRKTRIQAHMTEVMHLLNLDLTDDSLADTPRRIAKMYVDEIFSGLDYENFPKITLIQNKMKVDEMVTVRDITLTSTCEHHFVTIDGKATVAYIPKDSVIGLSKINRIVQFFAQRPQVQERLTQQILLALQTLLGTNNVAVSIDAVHYCVKARGIRDATSATTTTSLGGLFKSSQNTRQEFLRAVRHHG
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: INC10_ECOLI
Sequence: MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsC for insertion element IS2-10.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.
Protein: RS9_CLOAB
Sequence: MAKVQYMGTGRRKEAVARVRLVPGEGKVVINKRSAEDYFGLETLRFIVNQPLNLTGTKGKFDVLVNVHGGGFTGQAGAIRHGISRALLKADETLKGELKKAGFLTRDPRMKERKKYGLKKARRAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: KSS1_YEAST
Sequence: MARTITFDIPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHENIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYIANLPMRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEALRHPYLAMYHDPSDEPEYPPLNLDDEFWKLDNKIMRPEEEEEVPIEMLKDMLYDELMKTME
What is the function of this protein?
Together with closely related FUS3, KSS1 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively.  Phosphorylated KSS1 activates both pathways, whereas activated FUS3 activates the mating but suppresses the filamentation pathway.  KSS1 activity is down-regulated by FUS3 during pheromone induction to prevent inappropriate activation of the filamentation pathway.  During induction of filamentation, KSS1 activates the transcription factor STE12 resulting in its binding to and activation of filamentation specific genes.  Non-activated KSS1 has a kinase-independent repressive effect on STE12 transcriptional activity, that is mediated by direct binding to STE12 and depends on the presence of DIG1 and DIG2, and that is required for the suppression of filamentation under normal growth conditions.  SSN3/SRB10 contributes further to the suppression of filamentation under these conditions by reducing STE12 stability independent of KSS1.  FUS3 can partially compensate for the lack of KSS1 but filamentation becomes constitutively induced at a low level in the absence of any signal.  KSS1 phosphorylates STE7, STE5, FAR1, DIG1, DIG2, STE12, and SST2.
What are the official names of this protein?
Mitogen-activated protein kinase KSS1, MAP kinase KSS1, Kinase suppressor of SST2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Periplasm. Note=KSS1 shuttles rapidly between the cytoplasm and the nucleus independent of its activation state.
Protein: TBB8_MAIZE
Sequence: MREILHIQGGQCGNQIGSKFWEVVCDEHGIDPTGRYVGTSDLQLERVNVYYNEASCGRFVPGAVLMDLEPGTMDSVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPRGLSMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEAEYEDEEAIQDE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-8 chain, Beta-8-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.