PharMolix/UniProtQA huggingface dataset:
Protein: SYL_BREBN
Sequence: MVFSHRNVEKKWQQYWEQNKTFKTSEDEGKKKFYALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPAEFTEHNINTFRRQIKSLGFSYDWDREINTTDPHYYKWTQWIFTKLYEHGLAYIDEVAVNWCPALGTVLANEEVIDGKSERGGHPVERRPMKQWVLKITAYAERLLADLDELDWPESIKEMQRNWIGRSEGAEVTFGIEGHDESFTVFTTRPDTLYGATYAVLAPEHKLVEQITVPAQKEAVEAYLDQAKRKSDLERTDLAKEKTGVFTGAYAINPVNGERLPIWIADYVLISYGTGSIMAVPAHDERDYEFAKTFDLPIKQVIAGGDISKEAYAGDGEHINSGMLDGLNKEQAISKMIEWLEAEGKGNRKVTYRLRDWLFSRQRYWGEPIPILHLEDGTMKVVPESELPIMLPKTKEIKPSGTGESPLANIAEWVNTIDPETGMKARRETNTMPQWAGSCWYFLRFIDPHNDKALADPDKLKEWLPIDIYIGGAEHAVLHLLYSRFWHKFLYDIGVVPTKEPFQKLFNQGMILGENNEKMSKSKGNVVNPDDIIDSHGADTLRMYEMFMGPLDASIAWSTKGLDGARRFLDRVYRLFVGDNGELNEKIVETSNVAGMERVYHQTVKKVTEDYEGLRFNTGISQLMVFVNEAYKAEVLPKKFMEDFVKMLSPIAPHLGEELWEKLGHSESVAYAAWPTYDEAKLVEDEVEIVLQINGKNKEKLLIASDSTKEQMEEMAKNNEMINELIEGKTIVKVIAVPGKLVNIVVR
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EF1B_THEVO
Sequence: MADVLVSFKLLPSDSDVDTSVMESEVKEKLNGVCKINNIEEKDIGFGLKYIHLEVIVEDKEGEVDRIEKVLSMVKGVGEINTENVSLI
What is the function of this protein?
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
What are the official names of this protein?
Elongation factor 1-beta, EF-1-beta, aEF-1beta.
What is the protein family that this protein belongs to?
Belongs to the EF-1-beta/EF-1-delta family.
Protein: YBT1_YEAST
Sequence: MHHVLNSTRPDHRFWFYDDVTQYGRTKYLNYYTPLVLLIFTVLFITYNIWKHYYYYDVLHLKQKNPIDELLYSSTDEDEQSPLINNNTITTNYVDNNCTKDALKNRHFSLEKLKSVKVNGEPHGTPEIVRRGFIEKSRIILEFFLVLSQVIIHSFILLHYVNKNPEFTQQGTITGLVEWCALFIIVSLRLANVNQNFKFINKYPGNLWSVSFINYLALFISMILPFRSIFIHHINSPISRKYYISQISINLALFLLLFFARIRNNFAIIYKTDSWITPSPEPVTSIAGFICWAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVDHKVKRKRIFSLNLFFFFSNYLVLQCFWAFLGSVLSFIPTVLLKRILEYVEDQSSAPSNLAWFYVTVMFVGRILVAICQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFEKDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYVQGEVLTTPVAFTALSLFTLLRDPLDRLSDMLSFVVQSKVSLDRVQDFLNENDTKKYDQLTIDPNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKGLFGEDELVKSSILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKSLRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFGGWKIVSFLASLFLIAQLLYIGQSWWVRAWASHNVIAKIIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNEHKEIPPPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLISEEQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYSLLLNKQSAFYSMCEHSGELDILIELAKKAFVEKLNSKKD
What is the function of this protein?
Vacuolar class C ABC transporter which regulates the translocation of phosphatidylcholine to the vacuole lumen, the release of lumenal calcium stores, and acts as a negative regulator of vacuole fusion.  Exhibits ATP-dependent bile acid transport.
What are the official names of this protein?
ATP-dependent bile acid permease.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: Y591_ACIBC
Sequence: MKRILIVTGQSGSGKSSALQVLEDLGYYCIDNLPLALLPEIVAKLDHENNLEQLALGVDVRSTRADMQEFDHVFEQLQKHGTVDVIYLTTQDQDLIARFSASRRPHPLANRFKSLLQCIHEEKQLLIPIQFRATVHIDTTDKSVHDLKHILLSKLGQSDNLIVILQSFGYKHGIPLDADYVFDVRHLPNPHWDLELRRFSGLDEPVKQFLEASPQANEMFEDILHFLKKWLPAFAEGHRHYMTISIGCTGGQHRSVYMVDRLKQALEAEWSVQVLHREMKHWS
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein ACICU_00591.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: RSMH_LATSS
Sequence: MTETFKHQSVLLKETVDALNVQPDGIYVDATLGGGGHSEYLLSQLTTGHLYSFDQDDHALESSRQRLAKYADAGQVTFIKSNFRFLKIALAEQGITKIDGILYDLGVSSPQFDDAQRGFSYKKEAPLDMRMDQGAELTAYTVVNEWSYQQLIKIFFRYGEEKFSKQVARKIEQQREIAPIETTIQLADLIKEAIPAPARRTGGHPAKRIFQAIRIAVNDELGAIEDSVEQAIPLVKVGGRISIITFQSLEDRLVKTMFKEQATLPDIPKGLPIMPGTEKTVLKLVNRKPILPTEDELTVNHRAHSAKLRVAEKQKEID
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_SIVVT
Sequence: MRYTIITLGIIVIGIGIVLSKQWITVFYGIPVWKNSSVQAFCMTPTTSLWATTNCIPDDHDYTEVPLNITEPFEAWGDRNPLIAQAASNIHLLFEQTMKPCVKLSPLCIKMNCVELNSTRERATTPTTTPKSTGLPCVGPTSGENLQSCNASIIEREMEDEPASNCTFAMAGYVRDQKKNYYSVVWNDAEIYCKNKTNSTSKECYMIHCNDSVIKEACDKTYWDQLRLRYCAPAGYALLKCNDEDYNGYKQNCSNVSVVHCTGLMNTTVTTGLLLNGSYHENRTQIWQKHRVNNNTVLILFNKHYNLSVTCRRPGNKTVLPVTIMAGLVFHSQKYNMKLRQAWCHFEGNWRGAWREVKQKIVELPKDRYKGTNNTEHIYLQRQWGDPEASNLWFNCQGEFFYCKMDWFLNYLNNKTWDAYHNFCSSKKKGHAPGPCVQRTYVAYHIRSVINDSYTLSKKTYAPPREGHLQCRSTVTGMTVELNYNSKNRTNVTLSPQIESIWAAELGRYKLVEITPIGFAPTEVRRYTGGHERQKRVPFVLGFLGFLGAAGTAMGAAASSLTVQSRHLLAGILQQQKNLLAAVEAQQQMLKLTIWGVKNLNARVTALEKYLEDQARLNSWGCAWKQVCHTTVEWPWTNRTPDWQNMTWLEWERQIADLESNITGQLVKAREQEEKNLDAYQKLTSWSDFWSWFDFSKWLNILKMGFLVIVGIIGLRLLYTVYGCIVRVRQGYVPLSPQIHIHQVGKGRPDNADEPGEGGDNSRIKLESWXKDSKSRCMQLTAWLTRLNTWLYNSCLTLLIQLRKAFQYLQYGLAELKTGAQEILQTLAGVAQNACHQIWLACRSAYRNIVNSPRRVRQGLEEILN
What is the function of this protein?
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers.  Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells.  Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells.  This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: PDTAS_MYCTU
Sequence: MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQNSCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEGTFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML
What is the function of this protein?
In addition, the PdtaR/PdtaS two-component system controls copper and nitric oxide (NO) resistance downstream of the intramembrane protease Rip1 (PubMed:34003742).  This coupled Rip1/PdtaS/PdtaR circuit controls NO resistance and acute lung infection in mice by relieving PdtaR/PdtaS-mediated repression of isonitrile chalkophore biosynthesis (PubMed:34003742).  Two signals are required to fully inactivate the PdtaR/PdtaS system and mediate NO resistance: a cytoplasmic inhibitory signal through the PdtaS kinase mediated by direct sensing of NO and the production of PPE1-5', an NO-induced small RNA, to sequester PdtaR (PubMed:34003742).
What are the official names of this protein?
Sensor histidine kinase PdtaS, c-di-GMP sensing sensor histidine kinase PdtaS.
Protein: CINAL_SYNS9
Sequence: MAKTGVEILCVGTELLLGDILNGNARWLAQRLADLGLPHFRQTVVGDNTERLMGAVREAAGRCRILITTGGLGPTPDDLTTAALAAAFDTPLEERPELWEEIQAKLSAGGRAVAASNRSQAFLPIGADVLPNSLGSAPGMIWSPCPDFTILTFPGVPSEMRSMWVETAEPWLRQNAGAPSAFVSRRLHFTGIGESDLAEQVGDLLDSANPTVAPYAALGDVTLRLTASGSSPGQAEAVLHPMEEQLLQRTGRFCYGRDDDTLAAVVLRLLGEAGQTLAVAESCTGGALGAALTAVPGSSAVFSGGVIAYSNAVKQQLLGVPAALLDEHGAVSEPVVKAMAEGLRSRFHCDWGIAISGVAGPGGGTIEKPVGMVCLALAGREGCDLWVQRFGARRGRSAVQQLSVIRALDRLRLRLLAQS
What are the official names of this protein?
CinA-like protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: RL5_CHLAA
Sequence: MTVRLREKYQKEVVPALMEEFKFKSIMQVPRLVKIVVNVGVGEAVQNAKAIEAAVNDLATITGQKPVVTRAKKSVASFKLRAGMPIGAMVTLRGDRMYDFLDRLCSLALPRIRDFRGVSRSSFDGRGNYSLGLREQIVFPDIDYDKIDKIRGLEVAIVTSAPNDEQAYALLKRLGMPFRD
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: RLMF_ECOL6
Sequence: MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADYIHHLADLLAEASGTIPANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISANPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHNSATAARAGSERKRRNLGLNKDDALNFGGQQQELWCEGGEVAFIKKMIEESKGFAKQVMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DP2S_HALS3
Sequence: MPLEPSVRVVRELTSRGYNADREAVTLLAGADDPGAAVERAVAAAAADAATLTVSDVRAVLDAHTASSAAQTSAPASTPPDEATTHTDPSATDTPPNHDGGRAATADARSVEIDGDMTGASTGTGEYQDFVSVFRDRYDRLAAQLRGRVNHRPTSALASMPGGSDAAIVGMVNDIRSTTSGHWRVELEDTNGVFPVLVLKDRDVSDLVDDLLLDEVIAVSGTLADDGTILFADDIYFPEVPRTYSPSTADRSVQAALISDVHVGSQEFAADAWRSFADWLHTPAAESVEYLLIAGDMVEGVGVYPGQDEELDIVDIYDQYETFAEHLKDVPGDMEIVMIPGNHDAVRLAEPQPAFDEELRSIMRAHDARITSNPSTVTIDGVSVLLYHGVSLDEVIAEHPSDDVTYDDPQNAMELLLKKRHVAPPFGGRTRLAPEAEDHLAIDTVPDVFHTGHVHKLGVGIHHNVRLVNSGCWQHQTAFQESVNISPDVATAPILDLDTLDITVHKFS
What is the function of this protein?
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction.  Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
What are the official names of this protein?
DNA polymerase II small subunit, Pol II, Exodeoxyribonuclease small subunit.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase delta/II small subunit family.
Protein: DPOD_YEAST
Sequence: MSEKRSLPMVDVKIDDEDTPQLEKKIKRQSIDHGVGSEPVSTIEIIPSDSFRKYNSQGFKAKDTDLMGTQLESTFEQELSQMEHDMADQEEHDLSSFERKKLPTDFDPSLYDISFQQIDAEQSVLNGIKDENTSTVVRFFGVTSEGHSVLCNVTGFKNYLYVPAPNSSDANDQEQINKFVHYLNETFDHAIDSIEVVSKQSIWGYSGDTKLPFWKIYVTYPHMVNKLRTAFERGHLSFNSWFSNGTTTYDNIAYTLRLMVDCGIVGMSWITLPKGKYSMIEPNNRVSSCQLEVSINYRNLIAHPAEGDWSHTAPLRIMSFDIECAGRIGVFPEPEYDPVIQIANVVSIAGAKKPFIRNVFTLNTCSPITGSMIFSHATEEEMLSNWRNFIIKVDPDVIIGYNTTNFDIPYLLNRAKALKVNDFPYFGRLKTVKQEIKESVFSSKAYGTRETKNVNIDGRLQLDLLQFIQREYKLRSYTLNAVSAHFLGEQKEDVHYSIISDLQNGDSETRRRLAVYCLKDAYLPLRLMEKLMALVNYTEMARVTGVPFSYLLARGQQIKVVSQLFRKCLEIDTVIPNMQSQASDDQYEGATVIEPIRGYYDVPIATLDFNSLYPSIMMAHNLCYTTLCNKATVERLNLKIDEDYVITPNGDYFVTTKRRRGILPIILDELISARKRAKKDLRDEKDPFKRDVLNGRQLALKISANSVYGFTGATVGKLPCLAISSSVTAYGRTMILKTKTAVQEKYCIKNGYKHDAVVVYGDTDSVMVKFGTTDLKEAMDLGTEAAKYVSTLFKHPINLEFEKAYFPYLLINKKRYAGLFWTNPDKFDKLDQKGLASVRRDSCSLVSIVMNKVLKKILIERNVDGALAFVRETINDILHNRVDISKLIISKTLAPNYTNPQPHAVLAERMKRREGVGPNVGDRVDYVIIGGNDKLYNRAEDPLFVLENNIQVDSRYYLTNQLQNPIISIVAPIIGDKQANGMFVVKSIKINTGSQKGGLMSFIKKVEACKSCKGPLRKGEGPLCSNCLARSGELYIKALYDVRDLEEKYSRLWTQCQRCAGNLHSEVLCSNKNCDIFYMRVKVKKELQEKVEQLSKW
What is the function of this protein?
Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication (PubMed:2670563, PubMed:22119860, PubMed:31488849).  Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (PubMed:31488849).  Participates in leading strand synthesis during replication initiation and termination (PubMed:31488849).  Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (PubMed:1648480).
What are the official names of this protein?
DNA polymerase delta catalytic subunit, 3'-5' exodeoxyribonuclease, DNA polymerase III.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ANMK_BACCZ
Sequence: MYIAGVMSGTSLDGIDVALVRIEGSGVESKVELIHFTTVPFCNDIKSEIQQALSIENSNVQLICSLNFKLGLCFANAVKEVCKEANFSLEQLDLIGSHGQTIYHQPKQDGNRIPSTLQIGEPAVIAYETNTTVISNFRTMDMAAGGQGAPLVPYSEVILYRDPSKNRLLQNIGGISNVTVIPTQQSDQNVIAFDTGPGNMIIDEVCQRLFQLPYDQNGEIAKKGVVVDEILTYCMSHPFLKMNPPKSTGREQFGEEFVSELLKRFKKHSKENILTTVTMFTASSIVHHYKKFILPYYEIDEVILGGGGSYNSTLVEMLRNGLKDENCTIFIQEDIGYSSEAKEAIAFAILANETHHRNPSNVPSATGAKQSVVLGNVTFPPI
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: CDC6_PICTO
Sequence: MDNPFIKYSRSDDYIIGNLKTLSSSYIPDNLPHREQQIELMARSLSSIMHGGIASNILLYGQSGSGKTSSAINVTNMLRSAAGDRVSIHYINCEIYDSHYSIMVHMVNSFIGEEQIPNLGLPFDRIYYELVKRIKSRNLYTLIILDEIDRLLSKNGSDSLYVILKLLGDTEGSIIGITNDSSFINKLDMRVRSRLNAESIIFTPYNADELRDILKFRINGVIKNGFIEDSAINLCAAIGAQEHGDARKAIELLRIAIEYCIRENRERVTIDDIYMARERFEMNILKESVKTLPIHSKMVLLSAILTQEVSSDIAVTGEIYENYKNICAEIGLQPLSTRRISDLMSSLDDLGLIVTTTRSMGRYGRTKLIKVSQPVAIKNYILEDENFKNFQGSRIVRQSKLRTNYDDI
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: QUEA_LISIN
Sequence: MKVEDFDFDLPEELIAQTPLLDRTSSRLMVLDKESGEIKDQHFTDIISYLNKGDALVLNDTRVLPARLHGIKDETGAHIEVLLLKQKEGNAWETLVKPAKRIRKGATITFGDGALKATCLEELEHGGRILEFSYEGIFYEVLEQLGEMPLPPYIKEQLADQDRYQTVYAKENGSAAAPTAGLHFTEELLAQISAKGVEIIFVTLHVGLGTFRPVDVEDTQNHKMHSEFYRLTEESADRINKIKSAGGKVVAVGTTSIRTLETIASRHDGKLIAESGWTDIFISPGYEFQAVDALITNFHLPKSTLIMLVSALSDRTKILAAYNHAVEQQYRFFSFGDAMFIH
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTB_PAGBO
Sequence: MDPCECSKSGTCNCGGSCTCTNCSCTSCKKSCCPCCPSGCTKCASGCVCKGKTCDTSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein B, MT-B, MT-II.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: FABV_YERPB
Sequence: MIIKPRVRGFICVTAHPTGCEANVKKQIDYVTTEGPIANGPKRVLVIGASTGYGLAARITAAFGCGADTLGVFFERPGEEGKPGTSGWYNSAAFHKFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQDLGQVDQVIYSLASPRRTHPKTGEVFNSALKPIGNAVNLRGLDTDKEVIKESVLQPATQSEIDSTVAVMGGEDWQMWIDALLDAGVLAEGAQTTAFTYLGEKITHDIYWNGSIGAAKKDLDQKVLAIRESLAAHGGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKVMKEKGTHEGCIEQVYSLYKDSLCGDSPHMDQEGRLRADYKELDPEVQNQVQQLWDQVTNDNIYQLTDFVGYKSEFLNLFGFGIDGVDYDADVNPDVKIPNLIQG
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: Y323_RHOPA
Sequence: MAKTDRSQPSVLARIAAFRTGLSAEASAADYLERQGYRILARRFKTRCGEIDLVAQRDALVAFVEVKARGNVDDAAYAVTPRQQSRIVAAAEAWLSRHPEHAMSELRFDAILIAPNTAPRHLPGAFDATP
What are the official names of this protein?
UPF0102 protein RPA0323.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: CYSD_METCA
Sequence: MNAHKLTHLKQLESESIHIFREVVSEFERPVMLYSIGKDSAVMLHLAMKAFYPGKPPFPLMHVDTTWKFRDMIAFRDRRAQELGLDLIIHVNEEGVRQGINPFVHGSKKHTDIMKTEGLKQALDKYRFDAAFGGARRDEEKSRAKERVYSFRDRHHRWDPKNQRPELWNLYNGKINKGESIRVFPLSNWTELDVWQYIYLEDIPIVPLYFAAERPVVERDGMLIMVDDERMPLLPGEVPMRKKVRFRTLGCYPLTGAIESDAATLPEIIQEMLLTRTSERQGRLIDHDQAGSMEEKKKEGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: JUPIT_DROSI
Sequence: MISNFDCTDNQASSKVLRPPGGGSSDIFGSEMPQTPRNVKNRMASNIFAAEKDNGVKNNVRQGAHRFYFIGDAPRRGQKTVDSHSRLFGEPTRPITPGKNHMKSSIPFGQNTEAVAAQKLLTTNGHYNGKSGSVSSASSSVSSSTENLKMNSGSRSGEKRLALTGAGK
What is the function of this protein?
Binds to all microtubule populations.
What are the official names of this protein?
Microtubule-associated protein Jupiter.
What is the protein family that this protein belongs to?
Belongs to the MAP Jupiter family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
Protein: MURC_PSE14
Sequence: MVENQRAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKGSAVTERLESFGAQIFVGHRAENTVGADVLVVSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGTSRYLIAEADESDASFLHLQPLVAVVTNIDADHMATYEGDFNKLKKTFVEFLHNLPFYGLAVMCIDDPVVREILPLVKRPTLTYGFSESADIRAINVRQDGMLTFFTVLRRDREPLDVSVNMPGNHNVLNSLATIAIATDEGVSDEAIVQGLSGFQGVGRRFQVYGELPVEGGNVMLVDDYGHHPREVSAVISAVRGGWPDRRLVMVYQPHRFSRTRDLYDDFVQVLADANVLLLMEVYPAGEEPIPGADSRNLCHSIRQRGQLDPIYIERGVELAPLVKPLLRAGDILLCQGAGDIGGLAPQLLKSPLFAGAKAAPTEGKLK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCAH_DROME
Sequence: MGKQNSKLKPEVLEDLKQNTEFTDAEIQEWYKGFLKDCPSGHLSVEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFLCALSVTSRGKLEQKLKWAFSMYDLDGNGYISRQEMLEIVTAIYKMVGSVMKMPEDESTPEKRTDKIFRQMDRNKDGKLSLEEFIEGAKSDPSIVRLLQCDPQSH
What is the function of this protein?
Calcium-binding protein that is essential for promoting night-time sleep and inhibiting nocturnal hyperactivity (PubMed:7989365, PubMed:30865587).  During the night-time it promotes sleep by limiting synaptic output from arousal- and wake-promoting neurons within the C01- and A05- domains that include the mushroom body, and the antennal mechanosensory and motor center (PubMed:30865587).  Regulated by the circadian clock network and light-sensing circuits that include the CRY photoreceptor; it is likely that both of these internal and external cues are required to define the temporal window (the night-time) during which this protein functions (PubMed:30865587).  Inhibits the phosphorylation of rhodopsin in a calcium-dependent manner (PubMed:8626592).
What are the official names of this protein?
Neurocalcin homolog, DrosNCa.
What is the protein family that this protein belongs to?
Belongs to the recoverin family.
Protein: VDAC4_ARATH
Sequence: MGSSPAPFADIGKKAKDLLNKDYIFDHKFTLTMLSATGTEFVATGLKKDDFFFGDISTLYKGQNTIVDLKIDSHSSVSTKVTLKNLLPSAKAVISFKIPDHKSGKLDVQYVHPHATLNSSIGLNPTPLLDLSATIGSQNVCLGGEVSFDTASSSLTKYNAGIGFNNQGVSAALILEDKGESLRATYVHTVNPTTSFGAELIRRFSNYNNSFTVGSSHSVDQFTVVKTRFSNSGKAGMVVQREWRPKSHITFSAEYDSKAVTSSPKLGLALALKP
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.  The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.  The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).  Involved in plant growth and development at the vegetative and reproductive stages.  Is important for leaf and pollen development and mitochondrial membrane potential steady state.  May be involved in disease resistance.
What are the official names of this protein?
Mitochondrial outer membrane protein porin 4, Voltage-dependent anion-selective channel protein 4, AtVDAC4, VDAC-4.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1) family.