PharMolix/UniProtQA huggingface dataset:
Protein: HEM1_DESAP
Sequence: MLITVVGLNHRTAPLAVREKLSFPEHTLKEVLRGLSDREGVESCVVISTCNRTEVYAVLSEEDGLQNIWCFLAERCGSPVEAIKSHTYNYSFGESVRHLFRVSSGLDSMVLGETQILGQVKQAYQFAQQVGTVNWLLNCAFQQALAVGKRVRTETGIDKNPVSISYAAVELARQTLGSLEGREVLIVGAGKMSELTVKHLLSHGVAGVIVSNRSYPRAVELAAQFGGRAVRFDELYRWMGHADIVISCTAASHYVIRAEPMTSVLAERGGRAIFFIDIAVPRDVDPAVGHLPGVVLYDIDSLQSVVDANLAERRRAAVAAERIIDAEVREFLLALGSRFVIPTVVALKKRGEEIKRNELDRALNRLGGELSERELKVISSMANSIVSQLLHEPITRLKKLALTPEGHFYSDALQKLFNLEPENGGVPTLVGRTESCPVSCLKGKGC
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: COBD_CHRVO
Sequence: MNSALFLPIALLLDRLLGEPPRWHPLVGFGRLVKAVERAAYPAAPGAEPVWRMRLRGAAAIALLLAPFTLAAWALARLPLLEIIVPVALLYLAVGARSLAQHAEVVRKALAEGDLQLARERVGWIVSRDTRELDEAGVARATIESVLENGSDAVFAALFWFLVLGAPGAVLYRLANTLDAMWGYKNERYLHFGWAAARFDDMLNYLPARLTALTYLLLGHAAKGWRCWRTQAPTWYSPNAGPVMAAGAGALGVSLGGGARYHGQWKERPPLGCGPTPTHEDIGRAVRLVNRGMWLWAALSLAAAILIGAIHA
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CA050_DANRE
Sequence: MDRSVSLPHQPNKTTTVTLVETSSNPSGMVLVSPYQTNRVGDPMDLVSLAQQVQKGDEFIRANACNRLTVIADQIRYLQEQARKVLEDARKDAELHHAACNVVKKPGNMYYLYMRESGQRYFSILSPREWGASCPHKFLGGYKLQHDMSWTPQEDVEKRDAEIGIMDKLLNRQTALPACTEPNFEGLSQ
What are the official names of this protein?
Uncharacterized protein C1orf50 homolog.
Protein: DCVR_ARATH
Sequence: MSLCSSFNVFASYSPKPKTIFKDSKFISQFQVKSSPLASTFHTNESSTSLKYKRARLKPISSLDSGISEIATSPSFRNKSPKDINVLVVGSTGYIGRFVVKEMIKRGFNVIAVAREKSGIRGKNDKEETLKQLQGANVCFSDVTELDVLEKSIENLGFGVDVVVSCLASRNGGIKDSWKIDYEATKNSLVAGKKFGAKHFVLLSAICVQKPLLEFQRAKLKFEAELMDLAEQQDSSFTYSIVRPTAFFKSLGGQVEIVKDGKPYVMFGDGKLCACKPISEQDLAAFIADCVLEENKINQVLPIGGPGKALTPLEQGEILFKILGREPKFLKVPIEIMDFVIGVLDSIAKIFPSVGEAAEFGKIGRYYAAESMLILDPETGEYSEEKTPSYGKDTLEDFFAKVIREGMAGQELGEQFF
What is the function of this protein?
Catalyzes the conversion of divinyl chlorophyllide to monovinyl chlorophyllide.  Reduces the 8-vinyl group of the tetrapyrrole to an ethyl group using NADPH as the reductant.  The best substrate is (3,8-divinyl)-chlorophyllide a (DV-Chlidea).  Very low activity with (3,8-divinyl)-protochlorophyllide a (DV-Pchlidea) and (3,8-divinyl)-magnesium-protoporphyrin IX monomethyl ester (DV-MPE).  No activity with (3,8-divinyl)-chlorophyllide b (DV-Chlideb), (3,8-divinyl)-magnesium-protoporphyrin IX (DV-Mg-Proto) and either (3,8-divinyl)-chlorophyll a (DV-Chla) or b (DV-Chlb).
What are the official names of this protein?
Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic, Protein PALE-GREEN AND CHLOROPHYLL B REDUCED 2.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SLAP2_CAEEL
Sequence: MDHRAQAREVFVRAQLEAVQKAITKNEVPLKPKHARTIIVGTHKEKSSGIFWHTVGRIQLEKHPVLTWKFCHLVHKLLRDGHRKVPEETYRYVNRFTQLSQFWKHLNTSGYGPCIESYCKLLHDRVTFHNKYPVVPGKLDLNDSQLKTLEGDLDNMFEMTIDMLDQMDALLVLQDRVYEMMNSLRWNSLIPQGQCMLSPLIIAILDTSKFYDYLVKMIFKLHSQVPPDALEGHRSRFRTIFERTKKFYEESSNLQYFKYLVSIPTLPSHAPNFLQQSDLESYRTPHAYLHSEGSEDGTSLNGHDGELLNLAEAEPQQASPSSQPDPREEQIVMLSRAVEDEKFAKERLIQEARSRIEQYENRLLQMQGEFDHAKREADENREEAQRLKNELALRDASRTQTDDARVKEAELKATAAEERFNKMKGVYEKFRSEHVLALTKLGDIQKQLEASEKSKFDKDEEITALNRKVEEAQREAGRALTKAEGDAGAVDEMRTQLVKADIEVEELKRTIDHLRESHANQLVQSSAEETNKIRLAELEVAKESGVGITQMFDHCEDALQNATSITYPPHLAQSAMNNLVNILSNERLDEPLATKDNVFAGHLLSTTLSAAASAAYTASIESYEGVNDQCKKVLAAAKVAFSDDSALSRADKMKLLRQDIQTLNSLMISLPLQTDIDKDVVGNELEQEMRRMDDAIRRAVQEIEAIQRRARESSDGIRLEVNESILANCQALMSVIMQLVIASRELQTEIVAAGKAGGSPAEFYKRNHQWTEGLLSAAKAVGVAARVLVESADGVVTGKGKFEHLIVAAQEIAASTAQLFVSSRVKADKDSSKLDALSVAAKAVNQNTAQVVAAVKNGQTTLNDEGSLDFSYLSLHAAKKEEMESQVKMLELEQSLNQERAKLAALRKQHYHMAQLVANKEGEEAQE
What is the function of this protein?
Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons.  Plays a role in maintaining a normal defecation cycle.
What are the official names of this protein?
Huntington interacting protein related 1, Actin-binding protein SLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the SLA2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PUR9_ACAM1
Sequence: MTRLALLSTSDKTGLVELAQQLVNEYGFTLVSSGGTAVTIEKAGLPVTKVSDYTGSPEILGGRVKTLHPRIHGGILARRSLESDVQDLTENNIQGIDLVVVNLYPFEETIAKQKAQGITDPDQALADAVEQIDIGGPTMIRAAAKNHAHVTVLCDPQQYASYLQELKHGEGETSLPFRQACALKVFERMASYDRAIATHLRQSLATTDSQTQLSILGTAKQTLRYGENPHQNAVWYQESDTASGWAAAQQLQGKELSYNNLVDLEAARRVIAEFAQAETQPTVAILKHNNPCGVAQGETLLQAYEKALAADSVSAFGGIVAMNRAIDTDTAQVLTKTFLECIVAPECQPEAAAVLQAKSNLRVLVLPDLVSGPAVTVKAIAGGWLAQAADETLTPPADWQIVTQAKPTEAQLAELLFAWKVVKHVKSNAIVVTKDHTTLGVGAGQMNRVGSVNIALQQAGEKAQGGTLASDGFFPFDDSVRTAAAAGITAIIQPGGSIRDKDSIQAADELGIVMAFTGTRHFLH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: F163A_HUMAN
Sequence: MTAGTVVITGGILATVILLCIIAVLCYCRLQYYCCKKSGTEVADEEEEREHDLPTHPRGPTCNACSSQALDGRGSLAPLTSEPCSQPCGVAASHCTTCSPYSSPFYIRTADMVPNGGGGERLSFAPTYYKEGGPPSLKLAAPQSYPVTWPGSGREAFTNPRAISTDV
What are the official names of this protein?
Protein FAM163A, Cebelin, Neuroblastoma-derived secretory protein.
What is the protein family that this protein belongs to?
Belongs to the FAM163 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: TPIS_GORGO
Sequence: MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTKVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVITDNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
What is the function of this protein?
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
What are the official names of this protein?
Triosephosphate isomerase, TIM, Methylglyoxal synthase, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HCP_ECO55
Sequence: MFCVQCEQTIRTPAGNGCSYAQGMCGKTAETSDLQDLLIAALQGLSAWAVKAREYGIINHDVDSFAPRAFFSTLTNVNFDSPRIVGYAREAIALREALKAQCLAVDANARVDNPMADLQLVSDDLGELQRQAAEFTPNKDKAAIGENILGLRLLCLYGLKGAAAYMEHAHVLGQYDNDIYAQYHKIMAWLGTWPADMNALLECSMEIGQMNFKVMSILDAGETGKYGHPTPTQVNVKATAGKCILISGHDLKDLYNLLEQTEGTGVNVYTHGEMLPAHGYPELRKFKHLVGNYGSGWQNQQVEFARFPGPIVMTSNCIIDPTVGAYDDRIWTRSIVGWPGVRHLDGEDFSAVIAQAQQMAGFPYSEIPHLITVGFGRQTLLGAADTLIDLVSREKLRHIFLLGGCDGARGERHYFTDFATSVPDDCLILTLACGKYRFNKLEFGDIEGLPRLVDAGQCNDAYSAIILAVTLAEKLGCGVNDLPLSLVLSWFEQKAIVILLTLLSLGVKNIVTGPTAPGFLTPDLLAVLNEKFGLRSITTVEEDMKQLLSA
What is the function of this protein?
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
What are the official names of this protein?
Hydroxylamine reductase, Hybrid-cluster protein, HCP, Prismane protein.
What is the protein family that this protein belongs to?
Belongs to the HCP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PILR3_THUPL
Sequence: MDKKSRVLIVGGTGFIGKRIVKASLALGHPTYVLFRPEALSYIDKVQMLISFKQLGAKLLEASLDDHQGLVDVVKQVDVVISAVSGGLVRHHILDQLKLVEAIKEAGNIKRFLPSEFGMDPDVVEDPLEPGNITFIDKRKVRRAIEAATIPYTYVSSNMFAGFFAGSLAQLQDAPRMMPARDKVLIYGDGNVKGVYVDEDDAGIYIVKSIDDPRTLNKTVYIRPPMNILSQKEVVEIWERLSGLSLEKIYVSEDQLLNMKDKSYVEKMARCHLYHFFIKGDLYNFEIGPNATEGTKLYPEVKYTTMDSYMERYL
What is the function of this protein?
Reductase involved in lignan biosynthesis.  Catalyzes the enantioselective sequential conversion of (-)-pinoresinol into (-)-lariciresinol and of (-)-lariciresinol into (+)-secoisolariciresinol.  Abstracts the 4R-hydride from the NADPH cofactor during catalysis (By similarity).
What are the official names of this protein?
Bifunctional pinoresinol-lariciresinol reductase 3, PLR-TP3, (-)-lariciresinol reductase, (-)-pinoresinol reductase.
What is the protein family that this protein belongs to?
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Protein: SYQ_SALPC
Sequence: MSEAEARPTNFIRQIIDEDLASGKHTTVHTRFPPEPNGYLHIGHAKSICLNFGIAQDYQGQCNLRFDDTNPVKEDIEYVDSIKNDVEWLGFHWSGDIRYSSDYFDQLHAYAVELINKGLAYVDELTPEQIREYRGTLTAPGKNSPFRDRSVEENLALFEKMRTGGFEEGKACLRAKIDMASPFIVMRDPVLYRIKFAEHHQTGNKWCIYPMYDFTHCISDALEGITHSLCTLEFQDNRRLYDWVLDNITIPVHPRQYEFSRLNLEYTVMSKRKLNLLVTDKHVEGWDDPRMPTISGLRRRGYTAASIREFCKRIGVTKQDNTIEMASLESCIREDLNENAPRAMAVIDPVKLVIENYPQGESEMVTMPNHPNKPEMGSREVPFSGEIWIDRADFREEANKQYKRLVMGKEVRLRNAYVIKAERVEKDAEGNITTIFCTYDADTLSKDPADGRKVKGVIHWVSAAHALPIEIRLYDRLFSVPNPGAAEDFLSVINPESLVIKQGYGEPSLKAAVAGKAFQFEREGYFCLDSRYATADKLVFNRTVGLRDTWAKAGE
What are the official names of this protein?
Glutamine--tRNA ligase, Glutaminyl-tRNA synthetase, GlnRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LYSZ_PYRFU
Sequence: MRVVKIGGSVISMLENLWRENGISEILGNSVIVHGGSRHVDELSRKMGVKIEKLTSPSGVTFRRTTKEVLKVYVAAMIRANKEIVEFLRNQGINAIGLTGLDRELIIGERKKLIKAVINGRVVAIRDDYSGVIKKVNTQILREYLKIGTPVIASIAYDPIENTPLNVDGDKVAYHVALAMDAKELYFLSDTAFMAGGKVVSELPADEIEKYLIFAKGGMKKKLLMAKEAINSGIKNVVIEGLNGRTVIY
What is the function of this protein?
Involved in both the arginine and lysine biosynthetic pathways.  Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
What are the official names of this protein?
Putative [LysW]-aminoadipate/[LysW]-glutamate kinase.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. LysZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPPA_SHISS
Sequence: MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIANAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPVADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQCMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVEKEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH
What is the function of this protein?
Catalyzes the conversion of pppGpp to ppGpp.  Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
What are the official names of this protein?
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, Guanosine pentaphosphate phosphohydrolase, pppGpp-5'-phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the GppA/Ppx family. GppA subfamily.
Protein: UVRC_METMA
Sequence: MGRGSKMIDLEALPHLPGCYLFKDEEGIVLYVGKAKDLKKRVSSYFQKRDHDPKTASLMQFARGLDFIVTNTEVEAFLLENTLIKKHWPRYNIMLKDSKRYACIHLTGEKFPRIRIARKNTGEGEFFGPFVSARERDYIFEVVRKTFQLRTCRKMPSRACLRYHIGACSGPCISSVSVEEYGEKVKKAISVLKGNIRELIESMETEMKEMAAKQMFEQAMELRDEIAALEYLQEKQNMERQKKYDEDILNYIVRDNNVYLMLFKVYKGTLEDKQDFVFAFGEDFLEEFLVQYYSENDPPEELIVPEPLDESLVEFLAHVKGKKVKVAVPKQGDKKELLDLVLKNVEIGFFGDRKKLEALQSKLSLPKIPNVIECFDISHLSGTATVGSMVQFRGGRPDKHNYRRFKIESVEGIDDFASIAEVVRRRYSRLLEDKHEMPDLIIIDGGKGQLSSAFQELRKLRVKVPIISIAKREEEIYVPGLKSPLPIKKDEKASLFVQEIRDEAHRFAINYNRLLRQKALIQK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_STREM
Sequence: MSKKRLHEIAKEIGKSSKEVVERAKSLGLDVKSHASSVEEADANKIASSFAAGVTKDAQAGSAKDKQVAEQKAKAAKATTPQPAAATQEASQPVAVKPKSRNFKAEREARAKEQAARRQAGQNRSNDRKSDYRQLGRSQGQQTERAGHKSQNQQRDRRFDNRPSSGNNRNDGHRQAGNRDKNRSFNANSRQQDTGRQGQTQAGAPKIDFKARAAALKAEQNAEYARQRESRFREQEEAKRLEQQARQEAKAAALKAQTEDKKHREASAKATEPIASMAAAPVAKPVDKRRKKQNRPDKGHDRDHGLEDGQKKNKKSWNSQNQVRNQKNSNWNNNKKNKKGKHHKNSNTAPKPVTERKFHELPKEFEYSEGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGDTIELLMVDYGIEAKAKVEVDEADIERFFTDDSYLNPENIVERAPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIEEAGKKITFLDTPGHAAFTSMRARGASVTDITILIVAADDGVMPQTIEAINHSKAAGVPIIVAINKIDKPGANPERVISELAEHGIISTAWGGECEFVEISAKFNKNIDELLETVLLVAEVEELKADPTVRAIGTVIEARLDKGKGAVATLLVQQGTLHVQDPIVVGNTFGRVRAMTNDLGRRVKSAEPSTPVSITGLNETPMAGDHFAVYADEKAARAAGEERAKRALLKQRQNTQRVSLDNLFDTLKAGEIKTVNVIIKADVQGSVEALAASLLKIDVEGVRVNVVHSAVGAINESDVTLAEASNAVIIGFNVRPTPQARQQADADDVEIRLHSIIYKVIEEVEEAMKGKLDPEYQEKVLGEAIIRETFKVSKVGTIGGFMVVNGKVTRDSSVRVIRDSVVIFDGKLASLKHYKDDVKEIGNAQEGGLMIEGFNDIKVDDTIEAYVMEEIIRK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZA2G_RAT
Sequence: MVPVLLSLPLLLGPAVLQETGSYSLIFLYTGLSRPSKGLPRFQATAFLNDQAFFHYNSNSGKAEPVEPWSHVEGMEDWEKESQLQRAREEIFLVTLKDIMDYYEDSTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIPLDPAAANTKLKWEAEKVYVQRAKAYLEEECPTMLKKYLTYSRSHLDRTDPPTVKITSRVAPGRNRIFRCLAYDFYPQRISLHWNQASKKLASEPERGVFPNGNGTYLSWMEVEVPPQNRDPFVCHIEHKGLSQSLSVQWDEKSKV
What is the function of this protein?
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.
What are the official names of this protein?
Zinc-alpha-2-glycoprotein, Zn-alpha-2-GP, Zn-alpha-2-glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the MHC class I family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1296_CLOK1
Sequence: MEERIRLSILLDIYGELLTEKQRNVLDLYYNQDLSLAEIAEHTSTSRQAVYDIIKRCHMLLVHYEDKLNLMEEKKNIEENKKGIIDFIDSLYSDKNAEVLDKIKNYIMNNI
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein CKR_1296.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: CCML_NOSS1
Sequence: MQIAKVRGTVVSTQKDPSLRGVKLLLLQLVDEEGNLLQKYEVAADNSVGAGFDEWVLISRGSAARQLLGNEQRPVDAAVVAIIDTIHVEDRLIYSKKDQYR
What is the function of this protein?
Probably forms vertices in the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered.  Has been modeled to induce curvature upon insertion into an otherwise flat hexagonal molecular layer of CcmK subunits.
What are the official names of this protein?
Carboxysome shell vertex protein CcmL, Carbon dioxide concentrating mechanism protein CcmL.
What is the protein family that this protein belongs to?
Belongs to the CcmL/EutN family. CcmL subfamily.
What are the subcellular locations of this protein?
Carboxysome. Note=This cyanobacterium makes beta- type carboxysomes. Probably forms vertices in the carboxysome.
Protein: IPDB_MYCBO
Sequence: MSTRAEVCAVACAELFRDAGEIMISPMTNMASVGARLARLTFAPDILLTDGEAQLLADTPALGKTGAPNRIEGWMPFGRVFETLAWGRRHVVMGANQVDRYGNQNISAFGPLQRPTRQMFGVRGSPGNTINHATSYWVGNHCKRVFVEAVDVVSGIGYDKVDPDNPAFRFVNVYRVVSNLGVFDFGGPDHSMRAVSLHPGVTPGDVRDATSFEVHDLDAAEQTRLPTDDELHLIRAVIDPKSLRDREIRS
What is the function of this protein?
Involved in the final steps of cholesterol and steroid degradation.  Opens the last steroid ring of cholesterol by catalyzing the hydrolysis of (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA (COCHEA-CoA) to 6-methyl-3,7-dioxodecanedioyl-CoA (MeDODA-CoA).
What are the official names of this protein?
Cholesterol ring-cleaving hydrolase IpdB subunit, (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA hydrolase beta subunit, COCHEA-CoA hydrolase beta subunit.
What is the protein family that this protein belongs to?
Belongs to the 3-oxoacid CoA-transferase subunit B family.
Protein: RS13_CLOBH
Sequence: MARISGIDLPKEKRVEIGLTYIYGIGLPTSQEILKATGVNPDTRVKDLSEEEVNAIRDYVNKNVKVEGDLRREIKLNIKRLVEIGSYRGIRHRRNLPVRGQKTKTNARTRKGPKRAIGGKKKK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: LLDD_SHIB3
Sequence: MIISAASDYRAAAQRILPPFLFHYMDGGAYSEYTLRRNVEDLSEVALRQRILKNMSDLSLETTLFNEKLSMPVALAPVGLCGMYARRGEVQAAKAADAHGIPFTLSTVSVCPIEEVAPAIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYLQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLGNNFDPSISWKDLEWIRDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAFLYALATAGQAGVANLLNLIEKEMKVAMTLTGAKSISEITQDSLVQGLGKELPAALAPMAKGNAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FIBA_ERYPA
Sequence: ADTGEGDFLAEGGGVR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen alpha chain.
What are the subcellular locations of this protein?
Secreted.
Protein: AOFA_BOVIN
Sequence: MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHVDYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKLRSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADRLAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAEDVPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
What is the function of this protein?
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues.  Preferentially oxidizes serotonin.  Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline.
What are the official names of this protein?
Amine oxidase [flavin-containing] A, Monoamine oxidase type A, MAO-A.
What is the protein family that this protein belongs to?
Belongs to the flavin monoamine oxidase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
Protein: GCSPA_THEGJ
Sequence: MGKHYLPNLAHREEMLREIGFASIDELFSDVPEGMLKEFNLPGGKSEYEVFIELNETLSKNKTALEMPSFLGAGTYFHYIPAHVKYLIERSEFLTAYTPYQPEISQGMLQALFEYQSMMAELYGLPVVNSSMYDWGTSIAEAALMTVRLHRGKRKRFVIPKAISPEKKAVIETYTRGANLEIVEVPWDESGRLDIEKLKEAVEDSAGVYVEMANFFGLVEENVREIGEIAHEAGAYFVVGADPTMLGIFEAPGELGADIAVGEASYLGNPMNFGGPRAGVFAVRNDKKLIRQMPGRIIGMTRDAEGKRAFVMTLQTREQHIRRAKATSNICSNEALVAVASAIHLATLGPKGLRELGEVILKNTAYLKKRLSEVAEIPFEGLYFKDVPVKFKRPYGEIHEALLAKGIHGGYYIGKHFPELGETALFAATETTRKEWVHALIEALKEVA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: ATPG_RICBR
Sequence: MSNLKQLRTRIKSVKSTQKITKAMQLVSASKLTKIKNQIAHSNFYVEAISKMMSTVLSADIYDFPIEAQKFFNTETNKANLLIVMTSERGLCGTFNYMIIKQVKSDVETLKSKGEKIKLIIIGKKGYEALKKPYESYIDSYFELPKNHDENLMLQIKQKIMALVANLEVSNCTIYFNRFKNAMTQSMTKQQILPIEKYHDDSKIEEANYEYEGENLIQNLINLYVNSQINYALLQNRASEEGSRMTAMENATNNAHDIINKLVLKLNRSRQAIITTELIEIIAGSEAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RUVC_ALISL
Sequence: MSIILGIDPGSRITGYGVIRQNGRHLQYLGSGCIRMSEKELPGRLKQIYAGVSEIITQFQPDVFAIEQVFMSKNADSALKLGQARGSAIVAAVNADLPVYEYAARLIKQAVTGTGAADKAQVQHMVMTMLKLPARPQADAADGLGVAICHANTNKTLIALAGKATGARRGRYR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.