PharMolix/UniProtQA huggingface dataset:
Protein: APT_METI4
Sequence: MTFVLSSSIERLKEKIRTIPDFPRPGVMFKDITPAIGEGQFFRLILTIFIARYQKKKIDKIAAIDARGFIFAGALAHALGVGIIPIRKKGKLPYKTYELHYKSEYGEEVLTIHQDAISKGENILIVDDVLATGNTARTAALLVEKCGGNLMELGFLAELSNLKGRERLFPFPCYSILQF
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS14_STRPD
Sequence: MAKKSKIAKYQKQLQLIEQYADLRRDLKAKGDYESLRKLPRDSNPNRLKNRDKIDGRPHAYMRKFGVSRINFRDLAHKGQLPGVTKASW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: IDI2_BACCR
Sequence: MVRAKRKLDHIEYALSTGQSRTHGFHDIDFVHQSLPNSNYDTITCETKIGELSLSSPIFINAMTGGGGEKTLHINEQLAYVAKHHNLAMAVGSQMAALKDESEAASYKVIRKVNPNGIFFANLGSEATIEQAERAVDMIEANALQIHLNVIQELTMPEGDRDFTGVLQRIEKIVLNSKVPIIVKEVGFGMSKETMQQLVNVGVTAIDIGGQGGTNFAAVENERRQRMLSYFNNWGIQTATSIIEATSTNNNLSFIASGGIQTALDVAKAIALGANTTAFAGYFLRILMQDGIEKLVDEIELLHTDLKFIMTALGAKTIEELQSVPLVVKGETYHWLMQRGIDTAHYSRR
What is the function of this protein?
Involved in the biosynthesis of isoprenoids.  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
What are the official names of this protein?
Isopentenyl-diphosphate delta-isomerase, IPP isomerase, Isopentenyl diphosphate:dimethylallyl diphosphate isomerase, Isopentenyl pyrophosphate isomerase, Type 2 isopentenyl diphosphate isomerase, IDI-2.
What is the protein family that this protein belongs to?
Belongs to the IPP isomerase type 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1101_PASMU
Sequence: MLVINMKEDLERALKNKEPSFIIKGELAEKMKKAQRITTIDKWILGALAFVFAVSFFPSTSDGLFGIIMNKILIAIGIFATFEIAIILAVILGGMTLAMMLYKNYHAEFGTDVKTEKITIKCTIKK
What are the official names of this protein?
Uncharacterized protein PM1101.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RIMP_PSEA6
Sequence: MSQLEQKLTEMLTAPVEALGFEMVGIEFVRAGKHSTMRVYIDHPDGISVDHCAEVSHQVSAVLDVEDPINTEYNLEVSSPGMERPLFKLQHYIESVGEVVTLRLKMPMGDRRNFKGKLLSEADGMLTIEVDNQEFVLAFANIEKGNVVPTFD
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_RHIEC
Sequence: MNGRKLPDGGVLYDDTDESEDEIEVEGDVSAAPLAVAVDWNAGSLNETGLVGAELIGEFVKRLPNSPGVYRMLNAEGDVLYVGKARSLKKRVGNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITGDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDEGYAELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGVDEADVFAIHHEGGVSCIQVFFFRTGQNWGNRAYFPKADPQLSSAEVLNAFLAQFYDDKPVPKQIMLSETAEELELLAAALSEKAGHKVSILVPRRGEKRDLVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTDITPGDDFGMMKEVMTRRFSRLIKEEGIPDRTAQAAAADAADMPFPAWPDVILIDGGQGQMTAVRAILAELGITDSVTAIGIAKGVDRDAGRERFFAPGRESFTLPPRDPVLYFIQRMRDEAHRFAIGSHRVRRKKEMVKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVAKQVYNHFHEDAAK
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT134_HUMAN
Sequence: MGHFEKGQHALLNEGEENEMEIFGYRTQGCRKSLCLAGSIFSFGILPLVFYWRPAWHVWAHCVPCSLQEADTVLLRTTDEFQIYSWKKVIWIYLSALNSAFGLTPDHPLMTDEEYIINRAIRKPDLKVRCIKVQKIRYVWNYLEGQFQKIGSLEDWLSSAKIHQKFGSGLTREEQEIRRLICGPNTIDVEVTPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYAFAIIIMSIISISLTVYDLREQSVKLHHLVESHNSITVSVCGRKAGVQELESRVLVPGDLLILTGNKVLMPCDAVLIEGSCVVDEGMLTGESIPVTKTPLPKMDSSVPWKTQSEADYKRHVLFCGTEVIQAKAACSGTVRAVVLQTGFNTAKGDLVRSILYPKPVNFQLYRDAIRFLLCLVGTATIGMIYTLCVYVLSGEPPEEVVRKALDVITIAVPPALPAALTTGIIYAQRRLKKRGIFCISPQRINVCGQLNLVCFDKTGTLTRDGLDLWGVVSCDRNGFQEVHSFASGQALPWGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATTWEMAFSGDDFHIKGVPAHAMVVKPCRTASQVPVEGIAILHQFPFSSALQRMTVIVQEMGGDRLAFMKGAPERVASFCQPETVPTSFVSELQIYTTQGFRVIALAYKKLENDHHATTLTRETVESDLIFLGLLILENRLKEETKPVLEELISARIRTVMITGDNLQTAITVARKSGMVSESQKVILIEANETTGSSSASISWTLVEEKKHIMYGNQDNYINIRDEVSDKGREGSYHFALTGKSFHVISQHFSSLLPKILINGTIFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGISLSEQEASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKYMALYSMIQYVGVLLLYWETNSLSNYQFLFQDLAITTLIGVTMNLNGAYPKLVPFRPAGRLISPPLLLSVIFNILLSLAMHIAGFILVQRQPWYSVEIHSACTVQNESISELTMSPTAPEKMESNSTFTSFENTTVWFLGTINCITVALVFSKGKPFRQPTYTNYIFVLVLIIQLGVCLFILFADIPELYRRLDLLCTPVLWRASIVIMLSLNFIVSLVAEEAVIENRALWMMIKRCFGYQSKSQYRIWQRDLANDPSWPPLNQTSHSDMPECGRGVSYSNPVFESNEEQL
What are the official names of this protein?
Probable cation-transporting ATPase 13A4, P5-ATPase isoform 4.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
What are the subcellular locations of this protein?
Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.
Protein: PCKA_ECOL5
Sequence: MRVNNGLTPQELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLVTKQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGGEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDALLENVTVREDGTIDFDDGSKTENTRVSYPIYHIDNIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEKAETLAKLFIDNFDKYTDTPAGAALVAAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRK1_DANRE
Sequence: MAGQEDPVQREIHQDWANREYIEVITSSIKKIADFLNSFDMSCRSRLATLNEKLTALERRIEYIEARVTKGETLT
What is the function of this protein?
Involved in regulation of actin and microtubule organization.  Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
What are the official names of this protein?
Probable protein BRICK1.
What is the protein family that this protein belongs to?
Belongs to the BRK1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: UVRC_TREPS
Sequence: MRPSESLVETLRIQALSAPSTSGVYLWKDVHGVVIYVGKAKSLRTRLTSYFRCRHDPKTRVLMSRAAALEYLQTQHEYEALLLENTLIKKHTPRYNICLKDGKTYPLLKLTCEPFPRIFRTRQFCQDGARYFGPFPDVQILDSFLKLILRTYKIRTCTTLRKRKNPCLYYHLKRCDAPCCGWVSPRTYQKDIHEITLLLEGNIDATVARLEKRMKRAVRQEAFEAAARIRDDIQAIRCITHKSLVQDMDERARDYIAWSSTGAIVTFAVLRMRGGKLNGRELFRTRSLKNEEEILSEFLITYYSDHTIPPHLFVHSSAGLAEHWLSHKAGTQCTVTLIPLHTFPTPQTPSSTVTTNAPTLAASQNSNAVQDSGLRSCSETSTMHTLQKAHDACTASEGTRENTPHESAHTPHHRAILAMAQLNAHEDITRYLKNRGADDALKELQKQLHLARIPTLIEGFDISHLGGKYTVASLICFKNGAPDTKNYRLFNLRAHDTRIDDFASMREAIARRYTHTPEGYTLPDLILVDGGIGHVSAAQHVLDALGLSIPLVGLAKRAEELFIPNSPTPLVLDRRNPALHMLQRIRDEAHRFAITRNRHLRTKKELVLSFERLPHVGKVRAHRLLAHFGSFRSLQSATPQDIATAIHIPLTQAHTILHAATRSTTAPVREEYKEHEHDPQGESPGPGRKTD
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSUB_PECAS
Sequence: MTAFTDSITHAHSPSPLTKGTPLALDAITKHYGHRTVLNDVQLRIPSGQFVAIVGRSGCGKSTLLRLLAGLEAASSGELLTGTAPLSSAKDDTRLMFQEARLLPWKKVIDNVGLGLRGNWREKAQDALTSVGLADRANDWPAALSGGQKQRVALARALIHHPRLLLLDEPLGALDALTRIEMQSLIENIWLQHGFTVLLVTHDVSEAIALADRVILIEEGRVGLDITVDLPRPRRRGSAKLAELEARVLERVLAPTSSPLPQQAAI
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ARI2_MOUSE
Sequence: MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALHEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHFQLQLCPGADCPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYERIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT
What is the function of this protein?
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (By similarity).  Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity).  The initial ubiquitin is then elongated (By similarity).  E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex.  Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination.  May play a role in myelopoiesis (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase ARIH2, ARI-2, Protein ariadne-2 homolog, RING-type E3 ubiquitin transferase ARIH2, Triad1 protein, UbcM4-interacting protein 48.
What is the protein family that this protein belongs to?
Belongs to the RBR family. Ariadne subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MURD_DESVM
Sequence: MTCDKHTAQTIGKGDLVVVVGAGRSGMAAARLLHRMGARVRLLERNADGVPADFVRWAAEAGVEIATGDHAPTQFEGARAVVPSPGMAVSKLRPLLAQGPDAPEIMAEMELAWRQLDGEPVLAVTGTSGKTTTVSLCAAMLRAQGLSVFLGGNIGTPLSEYVLSVAHGGADGQGRADVLVIEISSFQLQACTTFRPRVAMLLNISENHLDYHADMAEYIDAKFRLFRCMEEGDLAIFGQGVRDLVAARDLKPRTLFFDAAARRFPRTCLLGGHNQANIEAAWQACREFGVTPEAAEKAVADFAPMEHRLEAVAERNGVLWVNDSKCTTVEALRVALQAFDRPVVLMVGGKFKGGDLASLLPLLCGRVRAVVGFGASREHFEGAWMGQGDFPMSWHPALEPAVAEAAALARPGDAVVMAPATSSFDLFANYKERGHAFRRAVEALP
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_RHOJR
Sequence: MSSTDDRRFEVLRAIVADYVSTQEPVGSKALVERHNLGVSSATVRNDMAFLESEGYIAQPHTSSGRVPTDKGYRQFVDRIADVKPLSTAERRAILEFLESGVDLDDVLRRGVRLLAQLTRQVAVVQYPTLSASSVRHLEVVALTPARLLLVLITDSGRVDQRIVELGDVLDDEDLARLRGLLGGALDGKRLAAASIAVSELADEAPEDLRDAVVRSATVLVETLVEHPEERLVLGGTANLTRNAADFSGISGFPGSLRAVLEALEEQVVVLKLLAATQDAGTVTVRIGEETQVEQMRGTSVISTGYGAAGTVLGGMGVLGPTRMDYPGTIASVAAVARYIGQVLAER
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: TIG_SHIBS
Sequence: MQVSVETTQGLGRRVTITIAADSIETAVKSELVNVAKKVRIDGFRKGKVPMNIVAQRYGASVRQDVLGDLMSRNFIDAIIKEKINPAGAPTYVPGEYKLGEDFTYSVEFEVYPEVELQGLEAIEVEKPIVEVTDADVDGMLDTLRKQQATWKEKDSAVEAEDRVTIDFTGSVDSEEFEGGKASDFVLAMGQGRMIPGFEDGIKGHKAGEEFTIDVTFPEEYHAENLKGKAAKFAINLKKVEERELPELTAEFIKRFGVEDGSVEGLRAEVRKNMERELKSAIRNRVKSQAIEGLVKANDIDVPAALIDSEIDVLRRQAAQRFGGNEKQALELPRELFEEQAKRRVVVGLLLGEVIRTNELKADEERVKGLIEEMASAYEDPKEVIEFYSKNKELMDNMRNVALEEQAVEAVLAKAKVTEKETTFNELMNQQA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: RL25_CERS5
Sequence: MAGEIPDFQAEVRTGTGKGAARQARREGYVPGIVYGGGQEPLSINVKYNDLLNRLKKGRFLQTLFNLKVEGQEDVRVICRGVQRDVVKDLPTHVDFMRLRRTSRINLFIHVTFENHDQAPGLKRGGTLTVVRPEVELEVTAGDIPDHITVDLTGKQIGDVIHIQDIALPEGAVPTINRNFVIANISAPSGLRSSDNEEEAAEA
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: WNT7B_HUMAN
Sequence: MHRNFRKWIFYVFLCFGVLYVKLGALSSVVALGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNQAEGWKWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMQLECKCHGVSGSCTTKTCWTTLPKFREVGHLLKEKYNAAVQVEVVRASRLRQPTFLRIKQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314).  Required for normal fusion of the chorion and the allantois during placenta development (By similarity).  Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314).
What are the official names of this protein?
Protein Wnt-7b.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: GLYA_MARN8
Sequence: MFTRDMKIAGFDDELWNAMQAEEKRQEAHIELIASENYTSPRVMEAQGSVLTNKYAEGYPGKRYYGGCEFVDIAEDLAIARAKELFGAAYANVQPHSGSQANSAVFMALLKPGDTVLGMSLAHGGHLTHGASVNFSGKIYSAVQYGLNPETGLIDYDEVEALAVEHKPKMIIAGFSAYSQELDFARFRAIADKVGAYLFVDMAHVAGLVAAGVYPDPVPHAHVVATTTHKTLRGPRGGLILACDDEDLQKKLNSAVFPGGQGGPLMHVIAAKAVCFKEAMSDEFKAYQQQVVKNAAAMAEVFIERGFDVVSGGTKNHLFLVSLIKQDITGKDADAALGKAHITVNKNAVPNDPRSPFVTSGLRIGTPAVTTRGFKEAECRNLAGWMCDILDNLEDEAVNSRVREQVEAVCARFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS18_BACAN
Sequence: MAGRKGGRAKRRKVCFFTSNGITRIDYKDVDLLKRFVSERGKILPRRVTGTSAKYQRKLTVAIKRARQMALLPYVGE
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: OPSD_POMMI
Sequence: MNGTEGPFFYIPMVNTTGIVRSPYEYPQYYLVNPAAYAALGAYMFFLILTGFPINFLTLYVTLEHKKLRTALNLILLNLAVADLFMVFGGFTTTMYTSMHGYFVLGRLGCNVEGFFATLGGEIALWSLVVLAVERWVVVCKPISNFRFTENHAIMGVAFSWIMAATCAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVIYMFIVHFLAPLIVIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVIIMVIGFLTSWLPYASVAWYIFTHQGTEFGPLFMTIPAFFAKSSALYNPMIYICMNKQFRHCMITTLCCGKNPFEEEEGASTTKTEASSVSSSSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: EPM2A_HUMAN
Sequence: MRFRFGVVVPPAVAGARPELLVVGSRPELGRWEPRGAVRLRPAGTAAGDGALALQEPGLWLGEVELAAEEAAQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSVCSL
What is the function of this protein?
Has phosphatase activity (in vitro).
What are the official names of this protein?
Laforin, Glucan phosphatase, Glycogen phosphatase, Lafora PTPase, LAFPTPase.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Under glycogenolytic conditions localizes to the nucleus. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Note=Colocalizes with glycogen synthase in punctate structures in the cytoplasm (PubMed:11739371, PubMed:14532330). Primarily associated with polyribosomes at the rough endoplasmic reticulum, and also detected at the plasma membrane (PubMed:11001928, PubMed:11220751, PubMed:11883934, PubMed:18311786). SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Nucleus. Note=Also found in the nucleus. SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm.
Protein: LYSK_THET2
Sequence: MSKSALDPVEFLKGALEIPSPSGKERLVAEYLAEGMQKLGLKGFVDEADNARGQVGEGPVQVVLLGHIDTVPGQIPVRLEGGRLFGRGAVDAKGPFVAMIFAAAGLSEEARKRLTVHLVGATEEEAPSSKGARFVAPRLKPHYAVIGEPSGWEGITLGYKGRLLVKARREKDHFHSAHHEPNAAEELISYFVAIKAWAEAMNVGQRPFDQVQYTLRDFRVHPAELRQVAEMFFDLRLPPRLPPEEAIRHLTAYAPPTIELEFFGREVPYQGPKDTPLTRAFRQAIRKAGGRPVFKLKTGTSDMNVLAPHWPVPMVAYGPGDSTLDHTPYEHVEVAEFLKGIEVLRGALEALAQTHAGEKEG
What is the function of this protein?
Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine (Probable).  In vitro, can deacetylate both N(2)-acetyl-L-lysine and N(2)-acetyl-L-ornithine (PubMed:11852094).
What are the official names of this protein?
[LysW]-lysine hydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. LysK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR7_AETCO
Sequence: MSRRGTAEEKTAKSDPIYRNRLVNMLVNRILKHGKKSLAYQIIYRALKKIQQKTETNPLSVLRQAIRGVTPDIAVKARRVGGSTHQVPIEIGSTQGKALAIRWLLGASRKRPGRNMAFKLSSELVDAAKGSGDAIRKKEETHRMAEANRAFAHFR
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S7, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS7_HERAR
Sequence: MPRRREVPKRDILPDPKFGNVDVAKFVNVLMLSGKKSVAENIIYGAFEHIQTKSGKDPLEVFTAAILNCKPLVEVKSRRVGGANYQVPVEVRPVRRMALSMRWLREAANKRSEKSMPQRLAGELLEAAESRGGAMKKRDEVHRMAEANKAFSHFRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: ACDH_ARATH
Sequence: MEAEVEEEEEDMFEDAVCTTQARVNTPLSVITEAFEDLADLVKPQRSDEIDEDELRLDDFCSACTHVSVLFNCLGFAFKFAEMEYIAKVKDLVEASKTFETLHNILDLDVEKETVKTPGSHSRNLRRVRQGLDLIRAIFEQFLIADDYSLKDAATTAYTEVCAPFHTWAVRTAVYAGMYTLPTRDQLLLRLNETDQSVEKNMRRYMEASRPIIEYIDKLYIERNIKLDW
What are the official names of this protein?
ACD11 homolog protein, Probable ceramide-1-phosphate transfer protein.
What is the protein family that this protein belongs to?
Belongs to the GLTP family.