PharMolix/UniProtQA huggingface dataset:
Protein: PTMQ_PENSI
Sequence: MDYVAQSPWIATLIVTATTYCTLRWVQYWRSWVNVPVVGRRGFLGSWISTILWTWEARGCIQKGYEKNKDFAFQVSTPNGWEVCICNDDMIKEYKNLMDDQMSALAVTSETFQAKYTLPGADWDAVHKLVPQPALAKSLMWLRNRAANDTDPYFPDFVRAFQRAFKEEIQVEQDGPFEWQSFPCFPRYSRVVAALTVKALLGSLANRPELIDLLCEYAEVIPLDGFFIALFPAILKPIVAFFCKAPRLSDRLVKVITEEIARRELENKHRIPEDMTDWMAQWVKDNPGYSIESAVVRVIATFFGGIHTTTQLTVHTLLEIATRPEYVDPLRQEITTALKAHGGWTKSAIESMTKLDSFIKEAQRFNPLDAASLARQATRDFQFSNGLKLPRGTWVFAPNGPMLFDESLYPAGSQFDGLRFWKLAEQTQRPHDYRLVTASSKYLQFGDGRHTCPGRFMAADEIRLIVAHTLFHFDIAIKNHGPRPRNTTFKKICFPDMSAEIMLRPRKLHGSEGN
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).  The geranylgeranyl diphosphate (GGPP) synthase ptmG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:25831977).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase ptmC then forms 3-geranylgeranylindole (3-GGI) (PubMed:25831977).  Epoxidation by the FAD-dependent monooxygenase ptmM leads to a epoxidized-GGI that is substrate of the terpene cyclase ptmB for cyclization to yield paspaline (PubMed:25831977).  Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase ptmP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase ptmQ (PubMed:25831977).  Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase ptmH which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase ptmD (PubMed:25831977).  A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase ptmV and ptmI leads to the production of the prenylated form of penijanthine (PubMed:25831977).  The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase ptmE (PubMed:25831977).  Five sequential oxidative transformations performed by the cytochrome P450 monooxygenases ptmK, ptmU, ptmL, ptmN and ptmJ yield the various penitrem compounds.  PtmK, ptmU and ptmM are involved in the formation of the key bicyclic ring of penitrem C via the formation of the intermediates secopenitrem D and penitrem D.  PtmL catalyzes the epoxidation of penitrem D and C to yield penitrem B and F, respectively.  PtmJ catalyzes the last benzylic hydroxylation to convert penitrem B to prenitrem E and penitrem F to penitrem A (PubMed:25831977).
What are the official names of this protein?
Cytochrome P450 monooxygenase ptmQ, Penitrem biosynthesis cluster 1 protein Q.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: ISPD_ACAM1
Sequence: MHLLIPAAGMGRRMGSDRNKLRLMLHGKPLLAWTLLAAESSISISWIGIIGQLEDEPTWETLLNTLSLNKPVVFIEGGQTRQESVYNGLQALPPEAEQVLIHDGARCLATPELLDRCAHALHKYQGFVAAVPVKDTIKVVDTTHQIQGTPDRSQLWAAQTPQGFQVVPLKKCHEQGRQQGWEVTDDAALFEKLDLPVHIVVGEETNLKVTTPADLAIAELILEQRLQKNSQTDGFGS
What is the function of this protein?
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, MEP cytidylyltransferase, MCT.
What is the protein family that this protein belongs to?
Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
Protein: 3SA1_NAJMO
Sequence: LKCNQLIPPFWKTCPKGKNLCYKMTMRAAPMVPVKRGCIDVCPKSSLLIKYMCCNTNKCN
What is the function of this protein?
Shows cytolytic activity on many different cells by forming pore in lipid membranes.  In vivo, increases heart rate or kills the animal by cardiac arrest.  In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
What are the official names of this protein?
Cytotoxin 1, CTX M1, Cardiotoxin IIB, CTX-IIB, Cytotoxin V(II)1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IA cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted. Target cell membrane.
Protein: SYR_SALCH
Sequence: MNIQALLSEKVSQAMIAAGAPADCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLSGIASKVEIAGPGFINIFLEPAFLAEQVQQALASDRLGVSQPTRQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHHVIRANHVGDWGTQFGMLIAWLEKQQQENAGDMALADLEGFYRDAKKHYDEDEAFAERARNYVVKLQSGDAYFREMWRKLVDITMTQNQITYDRLNVTLTRDDVMGESLYNPMLPGIVADLKAKGLAVESEGATVVFLDEFKNKEGDPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWTIVRKAGYVPDSVPLEHHMFGMMLGKDGKPFKTRAGGTVKLADLLDEALERARRLVAEKNPDMPADELEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKADIDEQALASAPVIISEDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDVAGLFSGFYEHCPILSAENDAVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_METRJ
Sequence: MDSFRPHLAKVAGGLALDRAEARAAFDDLLSGEVTPVQAGAFLTALKVRGESVEEIVGAAEAMRARMTRVAAPENAVDVVGTGGDHSGSVNVSTLAAIVVAACGVPVAKHGNRAATSRSGAADVLAALGVRLGLDPAAQARCLDEAGLCFLFAQAHHPAMRHVAAVRSELPVRTIFNLLGPLSNPAGVGYQLFGVAQAALAEPLTRVLAELGSRRVWTVHGSDGLDEITVTGPTQVVALDEGRLCHFTIDPREFGLALRAPEELRGGDPADNARSLEAVLAGARNAYRDIAVLNAGAALVVAGAAQALADGVAQAQDAVDSGAARATLARLVRASNDHSNGQEGR
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: CH60_BRUC2
Sequence: MAAKDVKFGRTAREKMLRGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEVELEDKFENMGAQMLREVASKTNDTAGDGTTTATVLGQAIVQEGAKAVAAGMNPMDLKRGIDLAVNEVVAELLKKAKKINTSEEVAQVGTISANGEAEIGKMIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMVADLEDAYILLHEKKLSNLQALLPVLEAVVQTSKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLESVTLDMLGRAKKVSISKENTTIVDGAGQKAEIDARVGQIKQQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVAGGGTALLRASTKITAKGVNADQEAGINIVRRAIQAPARQITTNAGEEASVIVGKILENTSETFGYNTANGEYGDLISLGIVDPVKVVRTALQNAASVAGLLITTEAMIAELPKKDAAPAGMPGGMGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK19_CYAPA
Sequence: MHTQQLISQIESQYLKDNLPEICVGDTVKVGVLIQEEDNKNSGEKERIQFYEGVVISLSKLKNINGTIRVRRILQGIGIERTFLVHSPLIKSINIIRRSKVRRAKLYYLRTLTGKATRLKQRLIKHYRLIY
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19, cyanelle.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
What are the subcellular locations of this protein?
Plastid, cyanelle.
Protein: LEUD_BACC7
Sequence: MEPFRIHKGTAAVLMNNNIDTDQIIPKQYLKRIERTGFGKFLFDEWRYDNERHENPNFPLNAPDRKGASILITGDNFGCGSSREHAPWALADYGFRVIIAGGFADIFYMNCMKNGMLPIVMDKEMREKLAKTDAREQIEVDLENEVITTSTHRFHFTIEKMWKEKLLNGLDEISITMQYEQEIKEYERRIAVY
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: LPXB_KLEP3
Sequence: MAEPRPLTIALVAGETSGDILGAGLIRALKARIPDARFVGVAGPLMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTRRFGELRPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKGAARDRLGIPHNVRCLALLPGSRGAEVEMLSADFLKTAQLLRVTYPDLQVVVPLVNAKRREQFERIKAETAPDMIVHMLDGQARDAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQDECEPQVLAAALQPLLADGKTSHEMHETFRALHQQIRCNADEQAADAVLELAKQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: FER_PORAE
Sequence: AKKYKVRLLSEAEGIDVTIDSADDVYILDAAEE
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: BIRC5_BOVIN
Sequence: MGAQSLPPAWQLYLKDHRVSTFKNWPFLEGCACTPERMAAAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLSEFLKLDKERTKNKIAKETNNKQKEFEETAKKVRCAIEQLAALE
What is the function of this protein?
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity).  Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity).  Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity).  Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity).  The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity).  May counteract a default induction of apoptosis in G2/M phase (By similarity).  The acetylated form represses STAT3 transactivation of target gene promoters (By similarity).  May play a role in neoplasia.  Inhibitor of CASP3 and CASP7 (By similarity).  Essential for the maintenance of mitochondrial integrity and function (By similarity).
What are the official names of this protein?
Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin.
What is the protein family that this protein belongs to?
Belongs to the IAP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody. Note=Localizes at the centromeres from prophase to metaphase, at the spindle midzone during anaphase and a the midbody during telophase and cytokinesis. Accumulates in the nucleus upon treatment with leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor (By similarity). Localizes on chromosome arms and inner centromeres from prophase through metaphase. Localizes to kinetochores in metaphase, distributes to the midzone microtubules in anaphase and at telophase, localizes exclusively to the midbody. Colocalizes with AURKB at mitotic chromosomes. Acetylation at Lys-129 directs its localization to the nucleus by enhancing homodimerization and thereby inhibiting XPO1/CRM1- mediated nuclear export (By similarity).
Protein: CUPG_DICDI
Sequence: MINIEDISKSSNQSEEKQLKSTSSKPKYSFAAKSLFKGSNNITPYYLSTSNTFQCVASESIQTWLLSDDGHIFTSSGNFVLDVSSGGYFVELVQLNSNSKTQIWTIDTTNNKIQNQGNGNYLDIDCFNICVAPLNGNATQQWTTFRRAPIPTGNWGYFQSKQLNSNNYWGLSVLNNSTSYNTSVVMNKVQAKSKGQIWQMTSDGHILSRLDGNLVLDIGPSINGSTTNYYLNTNVYKANDLMQQWGINENNQIFNQYYPNLCIGFVGQLGVDSTVNCVLAQPSSACDTYFQFIANPTYSLNQIVGEVPEPFPAYTSGDLLASYQYLSNDATSNFTDDIRSLYTGINVSLQSFLSIVTNATCPSSIHSTEDFSNVQNQIKTELIYAINVRLVFENYSGFYSKLFSQGSSNLTNLANLINVDMSSNQMVNANYTDAITSIFYSLISEIPVGGPIIANIGQSAVEFGELMSQSNYQGASTYQVELSQLYTHLNTNYENEMANAQSMKDTILQDWGMMSKTYALCFLPTNDPSSLNMNGLDFDEISDVASVAYEIAMIQMLLPTTYQIYFTPAGYWVPYSDGDFAYSDNSGTYIMATIEYSNSYPPKELTDKLWNNGVSKQEFFLSAYGWNLATSLTYYNNTKQHNNIFKLAFPTIKNFTGVPMQFVMTNEGDNLGNFTVKTHFAKFFSTYYSCGEAGHHYFDIAVTDINKNKVANFTVDIKLKALEGSYVSIKTGSLVVQPGYAVGNPICNQGSYSLMFSASILIPIYKSE
What is the function of this protein?
May play an important role in stabilizing and/or regulating the cell membrane during Ca(2+) stress or certain stages of development.
What are the official names of this protein?
Calcium up-regulated protein G.
What is the protein family that this protein belongs to?
Belongs to the cup family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein.
Protein: RS5_RICRS
Sequence: MSKVKKNDETLSEVLVDVNRVTKVVKGGRSFAFSAYVVVGDKAGRVGAGHGKAKEVNEARGKAKQAAKKRMMKVPLYQNRTIHHDVVGKSGAAKVILRRAKAGTGVIAGGSMRAIFDSLGIHDVVAKSIGSTNVYAMISATFDALNKLASPKSIAMRRDKKVNEISVKSADIQVNE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: BGL2_CANAX
Sequence: MQIKFLTTLATVLTSVAAMGDLAFNLGVKNDDGTCKDVSTFEGDLDFLKSHSKIIKTYAVSDCNTLQNLGPAAEAEGFQIQLGIWPNDDAHFEAEKEALQNYLPKISVSTIKIFLVGSEALYREDLTASELASKINDIKGLVKGIKGKNGKSYSSVPVGTVDSWDVLVDGASKPAIDAADVVYSNSFSYWQKNSQANASYSLFDDVMQALQTLQTAKGSTDIEFWVGETGWPTDGSSYGDSVPSVENAADQWQKGICALRAWGINVAVYEAFDEAWKPDTSGTSSVEKHWGVWQSDKTLKYSIDCKFN
What are the official names of this protein?
Glucan 1,3-beta-glucosidase, Exo-1,3-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Secreted, cell wall. Note=Tightly bound to cell wall.
Protein: VGA10_ALHV1
Sequence: MVYITRPPDRDPPNPPDGAAGGGPGAPEEVYANSGGTPDEKGEGGVKGGGGDDPQDPLLGDYSNSPEKAPGSTPASGGLGPYVLPPPLPDSDDDESPCPSWYWPLMLSQKTEYDKLDRSNEFEKDQDRRPQRPTTLALPVCLTTEVLVDGRTWHDQNLDGPDSMSTPGGGGASGRSPNGLGARPKDKGPKGKSPPKCGPAGKTPPKDLGARPKEKGPKGKSPPKDGPAAKNPPKDPGARPEKVPLAFPGPGPVDTNPSRHDVIEAAPGDENPYKKMWLPPGTKPPCPTPLWDPCAVLLSSGSTPPWDRRKGIHRNTKVKTIGTPVTPVYLTISDDDLDDRKGAAGGGPKKPPLPSRDPAGSGQRGPTPQSKESTSSGLSGATPRSKAPAGRGRQEPPPLPPRDYDPASPEALRLELRDIVQKVRYIGGAYNELEAIFRDNYERQRERERRMDYALIALIILLIIIVLLLIVL
What are the official names of this protein?
Uncharacterized gene A10 protein.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: PEX22_KLULA
Sequence: MRGDKETTNWLNKSLMKQARQKKLSIIAVGVLSTVAVTVGYLLYLYRGQRNPNIRDVKPKSKCYVLTQDLFDKIENWQEELSKDSVMLVLPEVAHLGNHLKLQLSSIEHKIVIFNNSSAVWSAVRHLKKYELVISRDKTSDMPVDLRRYVGQISHI
What is the function of this protein?
Involved in peroxisome biogenesis.
What are the official names of this protein?
Peroxisome assembly protein 22, Peroxin-22.
What is the protein family that this protein belongs to?
Belongs to the peroxin-22 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: RL21_CAPHI
Sequence: MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYRKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIIVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Protein: SPI_SCHGR
Sequence: SEDDGSASPESQEMSYTELPCPSICPLIYAPVCVEDSNQDFYLFVNECEVRKCGCEAGFVYTFVPREMCKATTSLCPMQTKSS
What is the function of this protein?
Serine protease inhibitor (PubMed:16839309, PubMed:23075397).  Inhibits porcine pancreatic elastase with a Ki of 58. 3 nM, human neutrophil elastase with a Ki of 3. 6 nM, cathepsin G with a Ki of 153. 5 nM, chymotrypsin with a Ki of 26. 7 nM and subtilisin with a Ki of 0. 68 nM.  Does not inhibit neutrophil protease 3 or pancreatic trypsin (PubMed:16839309).
What are the official names of this protein?
Greglin.
Protein: LCB2_YEAST
Sequence: MSTPANYTRVPLCEPEELPDDIQKENEYGTLDSPGHLYQVKSRHGKPLPEPVVDTPPYYISLLTYLNYLILIILGHVHDFLGMTFQKNKHLDLLEHDGLAPWFSNFESFYVRRIKMRIDDCFSRPTTGVPGRFIRCIDRISHNINEYFTYSGAVYPCMNLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKEDALVFSMGYGTNANLFNAFLDKKCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKLIREQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGAMGPTGRGVCEIFGVDPKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSESMPAPVLAQTISSLQTISGEICPGQGTERLQRIAFNSRYLRLALQRLGFIVYGVADSPVIPLLLYCPSKMPAFSRMMLQRRIAVVVVAYPATPLIESRVRFCMSASLTKEDIDYLLRHVSEVGDKLNLKSNSGKSSYDGKRQRWDIEEVIRRTPEDCKDDKYFVN
What is the function of this protein?
Catalytic subunit of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
What are the official names of this protein?
Serine palmitoyltransferase 2, SPT 2, Long chain base biosynthesis protein 2.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Membrane; Multi-pass membrane protein.
Protein: RPOC1_THEVB
Sequence: MPRLEQRFDYVKVSLASPERIIQWGQRTLPNGQVVGEVTKPETINYRTLKPEMDGLFCERIFGPAKDWECHCGKYKRVRHRGIVCERCGVEVTESRVRRHRMGYIKLAAPVTHVWYLKGIPSYMAILLDMPLRDVEQIVYFNSYVVLDPGNHPGLSYKQLLSEDQWQDIEEEIYREDSELEGVEVGIGAEAIQRLLRDLDLQAEADQLRQEILNSKGQKRAKLIKRLRVIDNFIATGAKPEWMVLTVIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLARLQEILAPEIIVRNEKRMLQEAVDALIDNGRRGRTVVGANNRPLKSLSDIIEGKQGRFRQNLLGKRVDYSGRSVIVVGPKLQMHQCGLPREMAIELFQPFVIHRLIRQQIVNNIKAAKRMIQRNDPQIWDVLEEVIEGHPVLLNRAPTLHRLGIQAFEPILVEGRAIQLHPLVCPAFNADFDGDQMAVHVPLSIEAQAEARMLMLASNNILSPATGKPIITPSQDMVLGCYYLTAENPKLPDYSDRYYANFQDVVMAYEQGHLPLHAFVWVRYDGEVDDGDTSEPQITTYEDGSRLLEYALRRVKEDANGQRISQYIRTTPGRIIYNQTIQEALAS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit gamma, RNAP subunit gamma, RNA polymerase subunit gamma, Transcriptase subunit gamma.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
Protein: INVA5_PAXIN
Sequence: MTPIAITPVAPVDIIYDLKHTERATESSPVTLLDVFSRAVSQYPDHELSFITSSAHDSTVHTKTFAEFNQHVHALAQAMRAWGKPTGSVIVVYLTEHEDNMAAVWASLLAGYVPCLQPALSAQQAHKEGHVGHIKNLFSSATWLTNESGAEQVQSISGLDIHLLSELKASAEAGVDFQAHQPNPDDEAILFLTSGSTGFSKAVVHTHRTILAACHAKGESYGLTSESKIMNWVGFDHVAGSLEMHIAPLLYGASQLHVHASAILSDPLRFLHLIEEKSIQLAFAPNFLLAKLTRDLEKRSDLFGKFDLSSIKRINSGGEAVVSSTAQAFARTLQNLAKDGDASFVISAGFGMTETCAGCIYDPINVLETPPSYEFLELGTPVAGCEMRIVNPEDGVTPRPDGESGELQVRGPMVFVRYYNNPEATSSSFVEGGWYRTGDVGIVEQGKMRLSGRIKDTVIVHGVSYGIPELETYLQTVEGVTHSFLAAAPYRAPGQETEGFVVFYSPTFDLDSEDAPAKLFATHRALRDVSVKLITLPPQQIIPIPINQMEKTTLGKLSRARLVNLLKQGELAKHIDRAEELVSIARGASFVAPSTETEKTLAGIYAGIFNLSVSDMSASENFFELGGTSIDVIRLKREGESAFDLPEIPTIQILKHPVISSLAKYVDSLISKDASQEEYDPIVPLQLTGNKTPIFMVHPGVGEVLIFVNLAKYFQNERPFYALRARGFEPGHPFFTTMDEMVSCYAAAVKRTQPHGPYAIAGYSYGGVVAFEVAKRLEAMGDEVKFTGLINIPPNIADRMHEIDWTGGMLNLSYFLGLVSKQDANDLAPSMRPLTRKEQLEIVWKLSPPERLVELQLTPEKLDHWVDIAGSLIECGKTYEPGSSVSVLDVFYAIPLRGSKEDWLNKQLKPWAGYSRAEPSYTDVPGQHYTLMDFDHVPGFQKIFRSRLEARGL
What is the function of this protein?
An L-tyrosine:2-oxoglutarate aminotransferase (probably invD) and atromentin synthetase invA5 catalyze consecutive steps to turn over L-tyrosine into atromentin, which represents the generic precursor molecule for the entire terphenylquinone and pulvinic acid family of pigments, which are widely distributed secondary metabolites in homobasidiomycetes.  The first step catalyzed by the aminotransferase converts L-tyrosine in to 4-hydroxyphenylpyruvate (4-HPP).  Adenylation of two 4-HPP monomers by the invA5 adenylation (A) domain, covalent tethering of the monomers as a thioester and oxoester onto the invA5 thiolation (T) and thioesterase (TE) domains, respectively, and symmetric C-C-bond formation between two monomers catalyzed by the invA5 TE domain leads to atromentin.
What are the official names of this protein?
Atromentin synthetase invA5, Nonribosomal peptide synthase-like enzyme invA5, NRPS-like.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: BETB_ECODH
Sequence: MSRMAEQQLYIHGGYTSATSGRTFETINPANGNVLATVQAAGREDVDRAVKSAQQGQKIWASMTAMERSRILRRAVDILRERNDELAKLETLDTGKAYSETSTVDIVTGADVLEYYAGLIPALEGSQIPLRETSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEAGLPDGVFNVLPGVGAETGQYLTEHPGIAKVSFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIVFDDADLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCKAAFEQKILARVERIRAGDVFDPQTNFGPLVSFPHRDNVLRYIAKGKEEGARVLCGGDVLKGDGFDNGAWVAPTVFTDCSDDMTIVREEIFGPVMSILTYESEDEVIRRANDTDYGLAAGIVTADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMAKFQSIF
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.
What are the official names of this protein?
Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.