PharMolix/UniProtQA huggingface dataset:
Protein: DNLJ_CLOBB
Sequence: MVDKIERIKELVEILNKYSYDYYVLDNPSVSDKDYDKEYDELKLLEKETGFVLPYSPTLRIGDVVLQGFNKYTHKGKLWSLDKAQSLDEIKDWHNRNIKFVNEMRAQGEDLPDLKYIATKKFDGLTVNLTYNKGGMLEVSATRGNGEIGENVTSQVKTIKSIPLKLQENDDLFEVHGEAIMTQEAFEKYNASADIPLKNLRNGAAGALRNLNIKETARRDLSAFFYDVGYKEGYQFKTYLEMMDFIKEKGLPIDEYLKVCTSIDDIKKEIEYIEKIRFDLNYDIDGLVIAIDDIRTRELLGYTVKYPKWAIAYKFEAQEATTKLLDVEWNVGRSGRIGPTAILEPVELAGVTVKRATLNNMDDIKRKGVRIGADVFVRRSNDVIPEIMGTLENTLENSEEICPPTECPACGSHVVLNGAHYFCENTLSCKPQLVKTIVHYASRDAMNIAGFSEKTAEQLFEKLNIKSISDLYKLKKEDLINLEKFGEKKSENLLNAIEKSKDCKLYSFIYALGIPNVGVKTAKDIVNKFKSIDGLKNATFEELVSVQDVGDIVAQDVIEFFKEEKVINTIDELLNLGVNPIFDEVKIVESIFKDKTVVTTGTLQNYSRTEIKTKLESLGAKVSGSVSKKTDYVIAGESAGSKLTKAEELGVKIISEEEFEKMLGRES
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: NAPA_CAMLR
Sequence: MNRRDFIKNTAIASACGVAGLSVPSSVLANTENKWRWDKAVCRFCGTGCGILVARQDGKIVAVKGDPAAPVNRGLNCIKGYFNAKIMYGEDRLVTPLLRVNAKGEFDKNGKFQQVSWQRAFDEMEKHFKKAYKEKGVEGIGIFASGQYTIQEGYAAAKLVKAGFRSNNIDPNARHCMASAVVGFMQTFGVDEPSGCYDDIELTDTIITWGANMAEMHPILWSRVSDRKLSNLDKVKIVNLSTFSNRTSHIADTEIIFKPNTDLAIWNYIAREIVYNHPEAMDKEFVEKHCIFTTGYADIGYGMRNNPNHPKFKASEKDTVAKQNSIILDDEEAVSLAYLGVKAGDKFEMKHQSAPDAHWEISFEDFKKALEPYTLDYVAKVAKGNEDESIEEFKKKLQELANLYIEKNRKVVSFWTMGFNQHTRGSWVNEQAYMVHFLLGKQAKPGSGAFSLTGQPSACGTAREVGTFSHRLPADMVVANPKHREISEKIWKVPAKTINPKPGAPYLKIMRDLEDGNIKFAWVQVNNPWQNTANANHWIAAAREMDNFIVVSDCYPGISAKVADLILPSAMIYEKWGAYGNAERRTQHWKQQVLPVGEAMSDTWQILEFAKRFKLKEVWGETKVDDKLTLPSILEEAKAMGYNEDDTLYDVLFANKEAKSFKANDPIAKGFDNSDVNGDERKIIGSDGKEFDGYGFFVQKYLWEEYRKFGLGHGHDLADFDTYHKVRGLRWPVVNGKETQWRFNTKFDYYAKKAAPNSDFAFYGAFAKELPKGDLIAPQTQEKYSLKNKAKIFFRPFMKAPERPSEEYPFWLCTGRVLEHWHSGTMTMRVPELFRAVPEALCYMNEDDAKKMQIAQGDIVWVESRRGKVKARVDFRGRNKPSKGLVYVPWFDENVYINKVTLDATCPLSNQTDFKKCAVKITKA
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: RS11_SULTO
Sequence: MSSRREIRWGIARVYASQNNTLITITDITGAEIISRASGGMVVKADREKPSPYAAMLAANKAATEAFDKGISAIHIKVRAQGGYGSKTPGPGAQPAIRALARAGFIIGRIEDVTPIPHDSIRRPGGRRGRRV
What is the function of this protein?
Located on the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: EMP_STAA8
Sequence: MKKKLLVLTMSTLFATQIMNSNHAKASVTESVDKKFVVPESGINKIIPAYDEFKNSPKVNVSNLTDNKNFVASEDKLNKIADSSAASKIVDKNFVVPESKLGNIVPEYKEINNRVNVATNNPASQQVDKHFVAKGPEVNRFITQNKVNHHFITTQTHYKKVITSYKSTHVHKHVNHAKDSINKHFIVKPSESPRYTHPSQSLIIKHHFAVPGYHAHKFVTPGHASIKINHFCVVPQINSFKVIPPYGHNSHRMHVPSFQNNTTATHQNAKVNKAYDYKYFYSYKVVKGVKKYFSFSQSNGYKIGKPSLNIKNVNYQYAVPSYSPTHYVPEFKGSLPAPRV
What is the function of this protein?
Adhesin that binds to the host cell extracellular matrix proteins fibronectin, fibrinogen, collagen, and vitronectin.
What are the official names of this protein?
Extracellular matrix protein-binding protein emp.
What are the subcellular locations of this protein?
Cell surface.
Protein: PYRDB_BACFN
Sequence: MADLSVNIGKLQMKNPVMTASGTFGYGEEFADFIDITRIGGIIVKGTTLHKREGNPYPRMAETPSGMLNAVGLQNKGVEYFSNHIYPRIKDIQTHMIVNVSGSAIEDYVKTAEIINELDKIPAIELNISCPNVKQGGMAFGVTTKGVSEVVQAVRSAYKKTLIVKLSPNVTDIAEMARAAEANGADSVSLINTLLGMAIDAERKRPILSTVTGGMSGAAVKPIALRMVWQVAKAVNIPVIGLGGIMNWKDAVEFMLAGASAIQIGTANFIDPAITIKVIDGINDYLERHGCKSVSEIIGALEV
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRUA1_PARUW
Sequence: MHCYKLTIAYDGTNYSGWQIQPNASSIQQKIQEALCILLKKEKVVLVGSGRTDAGVHAKGQVAHFHFQDYIDLSRLHVSLNGLLPRDIRIKAVEPVSPRFHSQYSAIRKEYHYYLHLNKVMDPFQRLYSWHFQRKIDVNILKKAAILFTGTHDFTSFANEAHRGTAAKNPVRTLYRLDIKPNEGGLRLEFEGDGFLYKMVRNIVGTLMDVASHKRAIEEINQIFAAKNRRQASLAAPPEGLFLIQVFYENENGCLD
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A 1, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I 1, tRNA-uridine isomerase I 1.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: PA_I83A5
Sequence: MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSDFHFIDERGDSIIVEVGDPNALLKHRFEIIEGRDRNMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFVEIGVTRREIHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIEPFLKTTPRPLRLPEGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLLAWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFEDCRDFSDLKQYNSDEPEQRSLASWIQSEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMILRTAIGHVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESIIEAESSVKEKDMTKEFFENKSETWTIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALK
What is the function of this protein?
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits.  The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching.  It consists in the hijacking and cleavage of host capped pre-mRNAs.  These short capped RNAs are then used as primers for viral mRNAs.  The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
What are the official names of this protein?
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PA family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=PB1 and PA are transported in the host nucleus as a complex.
Protein: RUVA_UREP2
Sequence: MNYLIFKVIYANANIVVGEHNFIGYQIRIPKDYELEINKFCKLYLYEYISIMPNKNLIIKDLYGFRTYNERLLFIDLISINSIGPKTAINILKYDIDTIIDAIATKNIDYLITIKGINQRNANLICDQLNYKYINKVNDKNNWAKELSIGLENLGYTKKDIEYAITKVKINSQQDIDISEIISSAIKEISLRHEN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: NCAP_I88A3
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTVERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYKRVGGRWMRELVLYDKEEIRRIWRQANNGDDATRGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFSARSALILRGSVAHKSCLPACVYGPAVSSGYDFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGTKVSPRGKLSTRGVQIASNENMDNMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFEKSTVMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: AQP3_LACBS
Sequence: MSATPIIHLRDVKKRTGVLNAWERVRNKPQVHWAMECFAEALGVFFYVYFGLGSTAAWVIGNILKQSGLSSVFQIGFAYAFGILFAIGVCAATSGGHFNPCVTIAFTIFRGFPPLKAVRYIVAQILGAYIASALVYNQWKVLIVESELLLKQAGVYETTMFTPNGPAGIFALYLLPGAQTLPRAFLNEFVNCFVLALVIWAALDPTSFMIPPVMAPFIIAAAYAGSIWGYAVPAISLNSARDIGCRLFALTIWGKSAAGGSYSAITALVNIPATLLAAVVYELFLVDSDRVVAGSHLEFMNVAANHRRHRHQAEDDNHGDADDSSQEKPV
What is the function of this protein?
Water channel-like protein that does not show transport of water nor ammonium across membranes.
What are the official names of this protein?
Aquaporin Lacbi1:307192.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein: MNAR1_DANRE
Sequence: MDAMPEYSLFLVRILEELDTKYSTVSYQDLCKSLCARFDLVHLAKLRSLLFYTACLDPAFPATLFKDKMRCSVEDQQSKKLMVAADIVTMFNLIQMNGGMAKDKLPMGPRPKFHKNQSFESCRSDTDVYKYNDNDRAYKLLDTRGHHVSRNSPKSDCNSCQQFIPTSDPNFLLGVTKDLKCRAASLDKLQHLPQYASVSPPPCEMQSTYFPMDIDSESTTDQESLHANPGIKDVYVSSGEPFTVHSCVQKRNIFKEDFHNLVAFSPHVITTECRANPKSGGNYHHRRELSKPPTFFNHSFELPYSNPYFEPVNSPLQNKGRVKHESLDDLQASTYFGPTTVSECVSNRRTSSKHGRQPAWPVKSLSLNTEEGPDFERSFLNGKVPKDNHRHNIGTMENDQHFQCAKDKPTASPSGFSKKSNGSKTKDMSSVACGPGIEKREVGRRYKDKSINCPSFQSSNVDNGMSVGTQTEQHESRKVKDYPSQNKFKERPPFKHSEEDSEIVSDNISDIFRFLDDMSVCESLGVVQPSCYNSNGSLSQVTKSDGDSSPERNTIKIGKTGIKLDRLFQSLENSDDELKESVCKLVLRIGEIEKKLESLSGVRGEISQVLSKLTRLDEKIQEPEVNGKSSDGGLVEQIKTDANLSPHVFQCHTTGHNMKVEKSPEWCCSEADGSESLRVKALKKSVFTRRSSRSLNEENSATESKVASITNSPRDWRTVSYSSHNGEEGKERDRHSEGKERHRKSREAERQYEAHQGHRSSKPPKDSYLVEQVFSPHHFPPTVKTHVKGSPLYTDLRLTGHADGKRSQPSWTIEEYKRNSGDKNKLSALDLQVQESLNPNNLEYWMEDIYTPGYDSLLKRKEAEFRRAKACKIGALIFAAACTVILVIVVPICTMKS
What is the function of this protein?
Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR.  Negatively regulates angiogenesis.  Negatively regulates cell growth (By similarity).  May play a role in neuronal development (PubMed:30080879).
What are the official names of this protein?
Major intrinsically disordered Notch2-binding receptor 1, Membrane integral NOTCH2-associated receptor 1, Ubiquitination and mTOR signaling protein, ubtor.
What is the protein family that this protein belongs to?
Belongs to the MINAR family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type IV membrane protein.
Protein: HDDA_ANETH
Sequence: MIFRSKAPLRLGFAGGGTDVSPYSDEYGGYVLNATVDMYAYCTIEVTNDNRVCFYAADREEIFEGNSLEEFELDGNLDLHKGIYNRVVKQFNHGRPLSFRMTTYSDAPAGSGLGSSSTMVVAILKGFVEWLNLPLGEYDVAHLAYEIERIDVGLSGGKQDQYAATFGGFNFIEFYKEDKVIVNPLRIKNWIINELENSMILYYTGVSRESAKIIDEQTKNTKEKNSRSLEAMHELKADALIMKEAILKGDLKTFAEYLGKSWEAKKRMASSISNSYLDKIYEVAIETGAYAGKVSGAGGGGFMMFIVDPTKKITVSRELNKMGGHTMNFHFVKHGTQGWRV
What is the function of this protein?
Catalyzes the phosphorylation of D-glycero-alpha-D-manno-heptose 7-phosphate at the C-1 position to form D-glycero-alpha-D-manno-heptose 1,7-bisphosphate.
What are the official names of this protein?
D-glycero-alpha-D-manno-heptose 7-phosphate kinase, D-alpha-D-heptose 7-phosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family.
Protein: MINC_XANC5
Sequence: MASVNVDFEQAGELKIGQVGIANLRVRTLDVPRLVQEMRERVSRAPKLFGRAAVILDFGGLSQVPDLATAKALLDGLRDAGVLPVALAYGTSEIDLLSQQLGVPLLAKFRAQYEPTAVSPPPPPPPPARAEPAPPAARPAPGRMQRTAVRSGQQLYAENCDLTVLSTVGAGAEVIADGSIHIYGTLRGRALAGAQGNPDARIFCRDFHAELVAIAGHYKVLDDVPMDLRGKAVQVWLEQDQIKIAALD
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: ACP1_CYCRE
Sequence: AWKLFDDGV
What is the function of this protein?
The synthetic peptide inhibits cell proliferation and induces apoptosis in cancer-derived cell lines Hep2 (IC(50)=1. 5 mM) and HCT15 and, to a lesser extent, in non-cancerous NIH/3T3 cells.  The mode of action is presumably an arrest in the G0/G1 phase.  Has DNA-binding activity.  Antiproliferative, proapoptotic and DNA-binding activities are increased by acetylation at Ala-1 and Lys-3.  Has no hemolytic activity against mouse erythrocytes.  Has antibacterial activity against S. epidermitis (MIC=60 ug), B. subtilis (MIC=30 ug), P. aeruginosa (MIC=30 ug) and E. coli strain ATCC 8739 (MIC=30 ug).  Antibacterial activity is decreased by acetylation.
What are the official names of this protein?
Anticancerous peptide 1, Cr-ACP1.
Protein: RL27_BORRA
Sequence: MATSKSGGSSKNGRDSISKRLGVKRSGGQFVRAGEIIIRQRGTKFHKGKNSGLGRDHTIFALKDGIVEFKTSKGRKYINII
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: NUSB_CORGL
Sequence: MSERRQDYKRHGSRYKARMRAVDILFEAESRDVDPVAIIDDRHKLARDTNPIVAPVAEYTETIINGVAVELDTLDVFLAEHIAETWTLGRLPSVDRAILRVASWEMIYNADVPVTTAIVEAVEIASEYSGDKSSAYINATLDAMASKVETLRERAANPEAVLAEASESLDDAPVAPWDDSDALDDSDEDFEAVDAAEVFEAEETVEVSEVAEDSEVSKVSEEKADES
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PVK3_POLAY
Sequence: PQVGLIPFPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-3, PolAe-PVK-3.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SECB_SALCH
Sequence: MSEQNNTEMAFQIQRIYTKDVSFEAPNAPHVFQKDWQPEVKLDLDTASSQLADDVYEVVLRVTVTASLGEETAFLCEVQQAGIFSISGIEGTQMAHCLGAYCPNILFPYARECITSLVSRGTFPQLNLAPVNFDALFMNYLQQQAGEGTEEHQDA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_METSB
Sequence: MPRSHNIEDYRNFGIMAHIDAGKTTTTERILYYSGKSHKIGEVHDGAATMDWMEQEQERGITITSAATTTFWNGKRLNIIDTPGHVDFTIEVERSLRVLDGAVCVLDGNQGVEPQTETVWRQADKYHVPRIVFVNKMDKIGADFYRCVDEIKTKVGGRPVCIQLPIGSESDFKGIIDLVRMKAVVWQDEALGAKYNDAEIPAELLAKAEEYRHILIETAVELDDDVMSAYLDGVEPDEETLKRLIRKAVRYITFIPILCGSAFKNKGVQPLLDAVVDYLPSPIDREAIKGVDVDTGEEVLRMPRDEDPFSMLAFKIMDDPFVGTLTFARVYSGHVESGTTVLNSTKDKKERIGRMLLMHANNREDVKEAYSGDIVALAGLKDTRTGDTLCDLSKPVILERMEFPEPVIEIAIEPKSKADQEKLGLALAKLAAEDPSFRVSTDQESGQTILKGMGELHLDIKVDILRRTYKVDANIGAPQVAYRERLTKRVEIDHTHKKQTGGTGQFARVIIVFEPNEAGAGNVFESKIVGGSVPKEFIPGVEKGINSVMGSGILAGFPVVDVKATLIDGGFHDVDSSVLAFEIAARAAFREALQKGGSVLLEPIMKVEVTTPEDYTGSVMGDLLGRRGQVQGQDMRGNAVVINAMVPLANMFGYVNQLRSFSQGRANYTMQFDHYEQVPAGEAAKVQAKYA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APOC4_CAMDR
Sequence: MSFSGHRSWAQHPLCFCILVLACVVVGQQEATGASPSPPPETSSSSWSLVPGKVKEWMEPLVTRPRERWPWFWGLEAFQGFVQTYFEDHLKDLVSRTQAWLHSSKDSLLSKAHNLCPQLLCEKGDQD
What is the function of this protein?
May participate in lipoprotein metabolism.
What are the official names of this protein?
Apolipoprotein C-IV, Apo-CIV, ApoC-IV, Apolipoprotein C4.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein C4 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TILS_ECO57
Sequence: MTLTLNRQLLTSRQILVAFSGGLDSTVLLHQLVQWRTENPGGALRAIHVHHGLSANADAWVTHCENVCQQWQVPLVVERVQLAQEGLGIEAQARQARYQAFARTLLPGEVLVTAQHLDDQCETFLLALKRGSGPAGLSAMAEVSEFAGTRLIRPLLARTRGELAQWALAHGLRWIEDESNQDDSYDRNFLRLRVVPLLQQRWPHFAETTARSAALCAEQESLLDELLADDLAHCQSPQGTLQIVPMLAMSDARRAAIIRRWLAGQNAPMPSRDALVRIWQEVALAREDASPCLRLGAFEIRRYQSQLWWIKSVTGQSENIVPWQTWLQPLELPAGQGSVQLNAGGDIRPPRADEAVSVRFKAPGLLHIVGRNGGRKLKKIWQELGVPPWLRDTTPLLFYGETLIAAAGGFVTQEGVAEGENGISFVWQRNA
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LST8_RAT
Sequence: MNTTPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEITPDRSMIAATGYQHIRMYDLNSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGTSHIWDLKTDHNEQLIPEPEFSITSAHIDPDASYMAAVNSAGNCFVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSSNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
What is the function of this protein?
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals.  mTORC1 is activated in response to growth factors or amino acids.  Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1.  Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases.  Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis.  mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).  mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.  Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity.  In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity.  mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive.  mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.  mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.  mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation.  mTORC2 regulates the phosphorylation of SGK1 at 'Ser-421'.  mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657' (By similarity).
What are the official names of this protein?
Target of rapamycin complex subunit LST8, TORC subunit LST8, G protein beta subunit-like, Protein GbetaL, Mammalian lethal with SEC13 protein 8, mLST8.
What is the protein family that this protein belongs to?
Belongs to the WD repeat LST8 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1087_SYNP2
Sequence: MNFWTLLLPPIAGTVIGYFTNDIAINMLFRPYKAIYIGDRRLPFTPGLIPANQDRLARNISRIIMGSLLTPEEIQKLAQKLLQTERIEAAIRWLLQLAFAQIQGEQEQKTAGILAAILRDLASESLPRLIKVWSREDTFLEAQVYQIFDQLLLDFKLTEAQARQLTDWLLRTVLTPDILRQATIDFLTDKNIEIIDTSLREKTSGTYWVVANLFGVKNSLTRLRAFCLEEREIANARLQELILTLEIRLKLRLWLQGLSLQNLPVSTVRQLRKSFHQTIRQYFQNKGAGLMEYIGESVDWDNLSVVILRRLQASQVLDSSLGVVSQELSLLLDRYLEKDLEKIISQVIPILAIDQVIIERVNNTSPRELERAIQGIVKNELQAIVNLGGVLGFLVGVAQSVILLLN
What are the official names of this protein?
UPF0754 membrane protein SYNPCC7002_A1087.
What is the protein family that this protein belongs to?
Belongs to the UPF0754 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL27_PIG
Sequence: MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF
What is the function of this protein?
Component of the large ribosomal subunit (PubMed:24930395).  Required for proper rRNA processing and maturation of 28S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
60S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL27 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasm. Rough endoplasmic reticulum. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (PubMed:24930395).