PharMolix/UniProtQA huggingface dataset:
Protein: NDH_MYCTU
Sequence: MSPQQEPTAQPPRRHRVVIIGSGFGGLNAAKKLKRADVDIKLIARTTHHLFQPLLYQVATGIISEGEIAPPTRVVLRKQRNVQVLLGNVTHIDLAGQCVVSELLGHTYQTPYDSLIVAAGAGQSYFGNDHFAEFAPGMKSIDDALELRGRILSAFEQAERSSDPERRAKLLTFTVVGAGPTGVEMAGQIAELAEHTLKGAFRHIDSTKARVILLDAAPAVLPPMGAKLGQRAAARLQKLGVEIQLGAMVTDVDRNGITVKDSDGTVRRIESACKVWSAGVSASRLGRDLAEQSRVELDRAGRVQVLPDLSIPGYPNVFVVGDMAAVEGVPGVAQGAIQGAKYVASTIKAELAGANPAEREPFQYFDKGSMATVSRFSAVAKIGPVEFSGFIAWLIWLVLHLAYLIGFKTKITTLLSWTVTFLSTRRGQLTITDQQAFARTRLEQLAELAAEAQGSAASAKVAS
What is the function of this protein?
Alternative, nonproton pumping NADH:quinone oxidoreductase that delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones (PubMed:15767566, PubMed:29382761, PubMed:29522317).  Ndh is probably the main NADH dehydrogenase of M. tuberculosis (PubMed:29382761).
What are the official names of this protein?
Type II NADH:quinone oxidoreductase Ndh, Type II NADH dehydrogenase Ndh.
What is the protein family that this protein belongs to?
Belongs to the NADH dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RL11_THISH
Sequence: MAKKIDAYIKLQVKAGQANPSPPVGPALGQRGVNIMEFCKAFNAQTQGLEPGLPIPVVITVYSDRSFTFITKTPPASILLKKAAGITSGSATPNTNKVGKVTRAQLEEIAKTKMPDLTAADLDAAVRSIAGSARSMGLEVEGV
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CAPP_AZOSB
Sequence: MTPDKDAPLREDIRLLGRLLGDTVRDQQGAASFDLIERIRQTSVRFRRDEDLAARRELEDTLDALSREQTIQVVRAFSYFSHLANIAEDQHHIRRSRAHLLAGSAPREGSLAHAVGHALDEQRLDPTDLAAFFDTALISPVLTAHPTEVQRKSILNCQTVIARLLDERDRMQLTPDEAEANLDALRRAVLTLWQTRMLRPAKLSVIDEVNNGLSYFETTFLRELPRLYAALEDRLAGAQPALANHELPAFLQVGSWIGGDRDGNPYVTADVLEEALAMQARVALDYYLDELHTLGSQLSLSQGLVGASDALLALADRSPDQSPHRSDEPYRRAIAGIYARLSATYRNLLGHPPARHAVAEAEPYADVAALADDLDTLHRSLVANGTAALARGRLRHLRRAVRVFGFHLAPIDLRQNSDVHERVVAELLEVARPGAAYLAQDEAGRCALLLDELATARPLASPHVRYSDDSEGELAIFRAARRAHLRYGRGAIHNCIISKTDDLSDLLELAVLLKEAGLLRPLEKALDVNIVPLFETIGDLENAAGVMDRLFSIPVYRELLAARDQTQEVMLGYSDSNKDGGFLTSGWALYKAEGELVEVFGRHGVRLRLFHGRGGSVGRGGGPSYQAILAQPDGAVQGQIRLTEQGEVIAAKYGNPEVGRRNLEVLVAATLETSLRRDGGDATPRTFLDTMQALSDAAFTCYRGLVYETPGFEQYFWESTVISEIAGLNIGSRPASRKKGTRIDDLRAIPWVFSWSQCRLMLPGWFGFGSAVKQWLAAHPKDGLGLLQRMYREWSFFATLLSNMDMVLSKTDLAIASRYAELVKDPVLRDSIFERIRSEWKDTVDALLAITEQVELLDANPLLKRSIRNRFPYLDPLNHVQVELLRRHREGNGEDARIRNGIHISINGIAAGLRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: MIAB_PSET1
Sequence: MSKKLHIKTWGCQMNEYDSQKMAELLDATNGYQLTDDATDADVILLNTCSIREKAQEKVFHQLGRWKLLKDDKPDLIIGVGGCVASQEGDSIRQRAPFVDVIFGPQTLHRLPEMIKQVQGDKGSSVVDISFPEIEKFDRLPEPKADGPSAFVSIMEGCSKYCTFCVVPYTRGEEVSRPVDDVLLEIAQLAEQSVREVNLLGQNVNAYRGDTHDGEICYFSDLIRLIAAIDGIDRIRYTTSHPVEFTQDIVDVYADVPELVDHLHLPVQSGSDRILNLMKRGHTAIEYKSTIRKLRKIRPNLSMSSDFIIGFPGETQDDFEATMKLISDVGFDMSFSFIYSARPGTPAADLPDDVTEQEKKERLYLLQNRITQMAQQISRQMFDTEQRILVEGPSKKNPMELRGRTENNRVVNFVGPHTVIGQFVDVRITEALPNSLRGDLIRTESEMNLRREIAPSAILTKAASLEPKPDTINEIGVATFVP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSOSA_HALNC
Sequence: MADVTGIALGMIETRGLVPAIEAADAMTKAAEVRLVGRQFVGGGYVTVLVRGETGAVNAAVRAGADACERVGDGLVAAHIIARVHSEVENILPKAPQA
What is the function of this protein?
Unlike beta-carboxysomes, alpha-carboxysomes (Cb) can form without cargo protein.  CsoS2 is essential for Cb formation and is also capable of targeting foreign proteins to the Cb.  The Cb shell assembles with the aid of CsoS2; CsoS1A, CsoS1B and CsoS1C form the majority of the shell while CsoS4A and CsoS4B form vertices.  CsoS1D forms pseudohexamers that probably control metabolite flux into and out of the shell.
What are the official names of this protein?
Major carboxysome shell protein CsoS1A.
What is the protein family that this protein belongs to?
Belongs to the bacterial microcompartments protein family. CsoS1 subfamily.
What are the subcellular locations of this protein?
Carboxysome. Note=This bacterium makes alpha-type carboxysomes.
Protein: RL23_DICDI
Sequence: MSKAQAVGSNYRVSLGLPVGAVMNSADNSGAKNLYVIAVKGIKGRLNRLPSAGVGDMVMATVKKGKPELRKKVCTGLVVRQRKHWKRKDGVYIYFEDNAGVMCNPKGEVKGNILGPVAKECSDLWPKVATNAGTIV
What are the official names of this protein?
60S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: HFQ_BURP6
Sequence: MSNKGQLLQDPFLNALRKEHVPVSIYLVNGIKLQGNIESFDQYVVLLRNTVTQMVYKHAISTVVPARPVNFHPDAEAAS
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: RL27_RHOPB
Sequence: MAHKKAGGSSRNGRDSAGKRLGIKAYGGERVIPGNIIARQRGTTWHPGLNVGMGTDHTLFAKVEGHVEFRAKANGRTFVSVLPIAVAAAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: SPNS3_MOUSE
Sequence: MSTECLKPQTGGPQSQSLSQGGQYGALASGTCLPPSTPVPWSLPRWRAYLAAAVLCYINLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAILSFGILLWSGAGLSSSFISYQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCALAVFYIFIPVGSGLGYVLGSTVAELTGNWRWALRLMPCLDAMALALLILLVPDVPRGAAEKQGEVAVRAPRSSWCEDVRYLGRNWSFVFSTLGVTAIAFVTGALGFWAPKFLFEARVVHGLQLPCFQEQCHSQDSLIFGALTVATGIIGVMLGAEASRRYKKVNPRAEPLICASSLFATAPCLYLALILASRTLLASYVFLALGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVAHVLGDAGSPYLTGLISSVLQAERPDSYLQHFLSLQHSFLCCAFAIVLGGGFFLLTALHLEKDQARARQPGKGTLDSKDIASRNTESQGLLSGTSTPTE
What is the function of this protein?
Sphingolipid transporter.
What are the official names of this protein?
Protein spinster homolog 3.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HEMG_LEIMA
Sequence: MASQSPKCLMLYSTTDGHTKTIMDTIARQLADETKVRCDVVDIKDGNSYVLADYEKVLLGASIRYGHFSAAFINYVKQHHSELSAMPSAFFSVNLTARKLDKNTATTNVYTRKFLNQSSWSPQLVGVFAGALWYPRYNFFDRVLIQFIMKVTGGETDSTKEIVYTDWAAVRRFASDFAALPLAVPPRPKANTVEKPDGILRSGSGAHCLLAIVGMSAAVIVGIRIIAAKRG
What is the function of this protein?
In E. coli extracts under anerobic conditions catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX, transferring electrons to fumarate reductase, presumably via menaquinone.  In vitro under aerobic conditions forms protoporphyrin IX using ubiquinone as an electron acceptor.  Complements an E. coli hemG deletion, allowing normal growth in vivo.
What are the official names of this protein?
Protoporphyrinogen IX dehydrogenase [quinone], Protoporphyrinogen IX dehydrogenase [menaquinone], Protoporphyrinogen IX dehydrogenase [ubiquinone], Protoporphyrinogen oxidase, PPO.
What is the protein family that this protein belongs to?
Belongs to the HemG family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PEPQ_ECOL5
Sequence: MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWVPVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPNSFWTEDVEVIALPKADGIGSLLPAARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNGHRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEMRSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQFHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHLAAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGIRIEDNVVIHENNVENMTRDLKLA
What is the function of this protein?
Splits dipeptides with a prolyl residue in the C-terminal position.
What are the official names of this protein?
Xaa-Pro dipeptidase, X-Pro dipeptidase, Imidodipeptidase, Proline dipeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
Protein: EV974_AMBCJ
Sequence: MKVLLCIAASCLMLLALNVSAENTQQEEQDYDYGTDTCPFPVLANKTNKAKFVGCHQKCNGGDQKLTDGTACYVVERKVWDRMTPMLWYECPLGECKNGVCEDLRKKEDCRKGNGEEK
What is the function of this protein?
Salivary chemokine-binding protein which binds to host chemokines CCL1, CCL3, CCL4, CCL8, CCL17, CCL18 and CCL22.
What are the official names of this protein?
Evasin P974.
What are the subcellular locations of this protein?
Secreted.
Protein: DMAP1_HUMAN
Sequence: MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAEPAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP
What is the function of this protein?
Involved in transcription repression and activation.  Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins.  Can also repress transcription independently of histone deacetylase activity.  May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription.  Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.  Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
What are the official names of this protein?
DNA methyltransferase 1-associated protein 1, DNMAP1, DNMT1-associated protein 1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.
Protein: IL3_MOUSE
Sequence: MVLASSTTSIHTMLLLLLMLFHLGLQASISGRDTHRLTRTLNCSSIVKEIIGKLPEPELKTDDEGPSLRNKSFRRVNLSKFVESQGEVDPEDRYVIKSNLQKLNCCLPTSANDSALPGVFIRDLDDFRKKLRFYMVHLNDLETVLTSRPPQPASGSVSPNRGTVEC
What is the function of this protein?
Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells.  Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated.  In addition, plays an important role in neural cell proliferation and survival.  Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation.  Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity).  Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (PubMed:8378315, PubMed:10376805).  Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity).
What are the official names of this protein?
Interleukin-3, IL-3, Hematopoietic growth factor, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor.
What is the protein family that this protein belongs to?
Belongs to the IL-3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZBT8B_HUMAN
Sequence: MEMQSYYAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSDAFSIILDFLYSGKLDLCGENVIEVMSAASYLQMNDVVNFCKTYIRSSLDICRKMEKEAAVAAAVAAAAAAAAAAAAAAAHQVDSESPSSGREGTSCGTKSLVSSPAEGEKSVECLRESPCGDCGDCHPLELVVRDSLGGGSADSNLSTPPKRIEPKVEFDADEVEVDVGEQLQQYAAPLNLAHVEEALPSGQAVDLAYSNYHVKQFLEALLRNSAAPSKDDADHHFSRSLEGRPEGAGVAMSSMMDVQADWYGEDSGDVLVVPIKLHKCPFCPYTAKQKGILKRHIRSHTGERPYPCETCGKRFTRQEHLRSHALSVHRSNRPIICKGCRRTFTSHLSQGLRRFGLCDSCTCVTDTPDDDDDLMPINLSLVEASSESQEKSDTDNDWPIYVESGEENDPAGDDSDDKPQIQPNLSDRETLT
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger and BTB domain-containing protein 8B.
What are the subcellular locations of this protein?
Nucleus.
Protein: KAC5_RABIT
Sequence: ATLAPTVLIFPPAPAQLATGAVTIVCVANKYFPDGTVTWEVDGKPLTTGIETSKTPQNSDDCTYNLSSTLTLQKSNYNSHNEYTCQVAQGAGSVVQSFSRKNC
What are the official names of this protein?
Ig kappa-b5 chain C region.
Protein: MTLD_SALPK
Sequence: MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGENEQVDTVSGVNAVSSIGDDVVDLIAHVDLITTAVGPVVLERIAPAIAKGLVKRKAQGVDAPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAILDESIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLPHVNLVKGIAAAMHFRSDEDPQAQELAALITEKGPQAALAQISGLDANSDVVAEAVNAYNATK
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: KAD_BRUA4
Sequence: MRLILLGPPGAGKGTQAGLLTKKHGIPQLSTGDMLRAAVAQQSEIGKRAKAVMDAGQLVSDEIVNQIVSERIDAPDCANGFILDGYPRTVPQAQALGTMLAGKGLKLDAVIELKVDENALVKRMESRVAETIAKGGQVRSDDNPEAFRKRLVEYREKTSPLSSYYAGTGELRVINGMAPVEEVTAEIERILVPA
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_MYCSK
Sequence: MAVVTMKQLLDSGTHFGHQTRRWNPKMKRFIFTDRNGIYIIDLQQTLTYIDKAYEFVKETVAHGGSIMFVGTKKQAQESIAEEATRVGMPYVNQRWLGGMLTNFSTVHKRLQRLKELEAMEQTGGFEGRTKKEILMLTREKNKLERSLGGIRDMQKVPSAIWVVDTNKEHLAVAEARKLNIPIIAILDTNCDPDVVDYPIPGNDDAIRSAALLTKVVASAVAEGLQARAGGGNGNKPEAEAAEPLAEWEQELLAGATASPTAAGAAPGTPEADIQTEPTAPQNP
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: DISA_CLOB8
Sequence: MRIEKGIGIKNVLKIMCPGTQLREGLENILRAKTGGLLVIGDDEEVMKLVDGGFYINSEYTPSYAYELAKMDGAIVITGDLKKIVCANAQLIPDSSIPTYETGTRHRTAHRVAKQTNNIVIAISQRRNIITMYKGDIKYVLRESSVILGKANQALQTLEKYVAVLERVINNLNLLEFQDLTTLFDVVTAIQRTEMVMRIVEEINMYILELGNEGRLISMQLNELVKHIERDGILLIRDYCKDGLQYNEVYEHIQKLNSSELLELDAVARTLGRGGIPLMDTLISPKGYRMLSKVPRIPSNVIDNLIKEFEELSNIIDADINDLDNVEGIGEARATAIKDGLKRIKEQVSLKKEI
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: GAGHB_DROME
Sequence: MANPNNIIRPSAFSSNERPVPSERHDLPEQHRVDMSVEQLTALIGQTVAQVLPGLIKQMNNNTLDFTDVSDQVVEPEYRNNLADFDRVPDIVKSIREFSGNPAEFGSWKKSVDRIMETYTPFVGTPKYYGILHTIRNKIVGSADVALESYSIPLDWKAMSRCLTLHYADKRDITTLEYQMSTLVQGHQQSVEDFHQDVYKNLSLILNKVGCMQMSRESEHFVTKMYREKALDTFIRGLRGDLPRLLAIKEPADLPSALHYCLKLENQTFRSNHAANKGQQSSFRGNEKPIPAPRNFQPSNAFGHRQPPPVPPRHPMRRPPQYLGQPFPAPRQHVSNFGNAPFIPPRQNYQQQWQQYNAPPRPFATKPQPRPEPMDVDGSVQTRNINYMNRPHSDINKRQKNYNIQTVNMRQPSIEVTGSSSSMTGYQRSMQDYETQNNINSTLNEYCDGQIDNLDSEQRDHVLHFLE
What is the function of this protein?
Strongly basic protein that binds directly to retroviral RNA and may be involved in its packaging and in the reverse transcription process.
What are the official names of this protein?
Retrovirus-related Gag polyprotein from transposon HMS-Beagle.
What are the subcellular locations of this protein?
Virion.
Protein: MGTC_BRUAB
Sequence: MVWKPLAHTAACLAGAFLLGGLIGFERQFRHRLAGLRTNTLVAVGAATFVVFSSLVSGDSSPTRVAAQIVSGIGFLGAGIIFKEGFNVRGLNTAATLWCSAAVGVLCGAGLISHAAVATVFIIAVNALLRPLVQVLEFQAMRRGAFQPTYAIDIICHGDAEAQVRALLLRDIGDHLHIHELESSNIEGTNRVEVSATVRADQRQDRLLEQIVGHLSLEPRITSARWRIEDDSGGLSGL
What is the function of this protein?
Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival.  May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity).
What are the official names of this protein?
Protein MgtC.
What is the protein family that this protein belongs to?
Belongs to the MgtC/SapB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: I10R1_HUMAN
Sequence: MLPCLVVLLAALLSLRLGSDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQTLSYDLTAVTLDLYHSNGYRARVRAVDGSRHSNWTVTNTRFSVDEVTLTVGSVNLEIHNGFILGKIQLPRPKMAPANDTYESIFSHFREYEIAIRKVPGNFTFTHKKVKHENFSLLTSGEVGEFCVQVKPSVASRSNKGMWSKEECISLTRQYFTVTNVIIFFAFVLLLSGALAYCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLKVSPELKNLDLHGSTDSGFGSTKPSLQTEEPQFLLPDPHPQADRTLGNREPPVLGDSCSSGSSNSTDSGICLQEPSLSPSTGPTWEQQVGSNSRGQDDSGIDLVQNSEGRAGDTQGGSALGHHSPPEPEVPGEEDPAAVAFQGYLRQTRCAEEKATKTGCLEEESPLTDGLGPKFGRCLVDEAGLHPPALAKGYLKQDPLEMTLASSGAPTGQWNQPTEEWSLLALSSCSDLGISDWSFAHDLAPLGCVAAPGGLLGSFNSDLVTLPLISSLQSSE
What is the function of this protein?
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.  Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608).  In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952).  These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3.  Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes.  In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683).
What are the official names of this protein?
Interleukin-10 receptor subunit alpha, IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1.
What is the protein family that this protein belongs to?
Belongs to the type II cytokine receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Protein: TSX_SALTY
Sequence: MKKTLLAVSAALALTSSFTANAAENDQPQYLSDWWHQSVNVVGSYHTRFSPKLNNDVYLEYEAFAKKDWFDFYGYIDIPKTFDWGNGNDKGIWSDGSPLFMEIEPRFSIDKLTGADLSFGPFKEWYFANNYIYDMGDNKASRQSTWYMGLGTDIDTGLPMGLSLNVYAKYQWQNYGASNENEWDGYRFKVKYFVPITDLWGGKLSYIGFTNFDWGSDLGDDPNRTSNSIASSHILALNYDHWHYSVVARYFHNGGQWQNGAKLNWGDGDFSAKSTGWGGYLVVGYNF
What is the function of this protein?
Functions as substrate-specific channel for nucleosides and deoxynucleosides.  Functions also in albicidin uptake and as receptor for colicin K.
What are the official names of this protein?
Nucleoside-specific channel-forming protein Tsx.
What is the protein family that this protein belongs to?
Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: HEMA_INBNY
Sequence: MKAIIVLLMVVTSNADRICTGITSSNSPHVVKTATQGEVNVTGVIPLTTTPTKSHFANLKGTKTRGKLCPNCLNCTDLDVALARPMCIGTIPSAKASILHEVRPVTSGCFPIMHDRTKIRQLPNLLRGYENIRLSTHNVINAERAPGGPYRLGTSGSCPNVTSRSGFFATMAWAVPRDNKTATNPLTVEVPYICTKGEDQITVWGFHSDNKTQMKNLYGDSNPQKFTSSANGVTTHYVSQIGGFPNQTEDGGLPQSGRIVVDYMVQKPGKTGTIVYQRGVLLPQKVWCASGRSKVIKGSLPLIGEADCLHEKYGGLNKSKPYYTGEHAKAIGNCPIWVKTPLKLANGTKYRPPAKLLKER
What is the function of this protein?
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell.  Plays a major role in the determination of host range restriction and virulence.  Class I viral fusion protein.  Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane.  Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide.  Several trimers are required to form a competent fusion pore.
What are the official names of this protein?
Hemagglutinin.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses hemagglutinin family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein. Note=Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
Protein: TMKL1_ARATH
Sequence: MGMEALRFLHVIFFFVLILHCHCGTSLSGSSDVKLLLGKIKSSLQGNSESLLLSSWNSSVPVCQWRGVKWVFSNGSPLQCSDLSSPQWTNTSLFNDSSLHLLSLQLPSANLTGSLPREIGEFSMLQSVFLNINSLSGSIPLELGYTSSLSDVDLSGNALAGVLPPSIWNLCDKLVSFKIHGNNLSGVLPEPALPNSTCGNLQVLDLGGNKFSGEFPEFITRFKGVKSLDLSSNVFEGLVPEGLGVLELESLNLSHNNFSGMLPDFGESKFGAESFEGNSPSLCGLPLKPCLGSSRLSPGAVAGLVIGLMSGAVVVASLLIGYLQNKKRKSSIESEDDLEEGDEEDEIGEKEGGEGKLVVFQGGENLTLDDVLNATGQVMEKTSYGTVYKAKLSDGGNIALRLLREGTCKDRSSCLPVIRQLGRIRHENLVPLRAFYQGKRGEKLLIYDYLPNISLHDLLHESKPRKPALNWARRHKIALGIARGLAYLHTGQEVPIIHGNIRSKNVLVDDFFFARLTEFGLDKIMVQAVADEIVSQAKSDGYKAPELHKMKKCNPRSDVYAFGILLLEILMGKKPGKSGRNGNEFVDLPSLVKAAVLEETTMEVFDLEAMKGIRSPMEEGLVHALKLAMGCCAPVTTVRPSMEEVVKQLEENRPRNRSALYSPTETRSDAETPF
What is the function of this protein?
Does not seem to have conserved a kinase activity.
What are the official names of this protein?
Putative kinase-like protein TMKL1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.