PharMolix/UniProtQA huggingface dataset:
Protein: CUL1_SCHPO
Sequence: MTTLNTNDKDLPIVKKYDSLNGTWDFLKTGVSQIFERLDEGMTITKYMELYTAIHNYCADASKTITVDNFNDQTANVLGEALYNNLVLYLEEYLARLRKECISQTNHEEQLAAYAKYWTRFTTSARFINHLFGYLNRYWVKLKNRFTETLVYDIYTLCLVSWHHHVFSHIRDSLLQNLLYMFTKKRLYEPTDMKYVEVCVDSITSLSFDKTDMTKPNLSSYKTFFETNFIENTKNFYAKESSEYLASHSITDYLKKAEIRLAEEEELVRLYLHESTLKPLLEATEDVLIAQHEEVLHNDFARMLDQNCSEDIIRMYRLMSRTPNGLQPLRQTFEEFVKRSGFAAVAKIVPQVGGEADVDPKEYMEMLLSTYKASKELVNTAFHGDTDFTKSLDTAFRELVNRNVVCQRSSSRSPELLAKYADSILRKSNKNVDIDDVEDCLSSIIIIFRYVEDKDVFQNFYTKLLAKRLVNGTSNSQDAESSMLSKLKEVCGFEYTSKLQRMFQDISLSQEITEAFWQLPQSRAGNIDFSALVLGTSFWPLSPNNVNFHLPEELVPLYEGFQNYYYSCHNGRKLSWLFHLSKGEIKARINPQTNVTYVFQVSTYQMGVLLLYNHRDSYTYEELAKITGLSTDFLTGILNIFLKAKVLLLGDNDKLGDPNSTYKINENFRMKKIRVQLNLPIRSEQKQESLETHKTIEEDRKLLLQSAIVRIMKARRTLKHVVLVKETIDQIKSRFTPKVSDIKQCIDMLIEKEYLERQGRDEYIYLA
What is the function of this protein?
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins.  The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component.  SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2.
What are the official names of this protein?
Cullin-1, Cul-1, Cell division control 53 homolog.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MVD1_PANGI
Sequence: MAESWVIMVTAQTPINIAVIKYWGKRDETLILPINDSIRVSLDPDHLCTTTTVSVRPSFEQDRMWLNGKEISLLGGRFQSCLREIRSRARDLEDEKKGIVIKKMDWEKLHFHIASYNNFPTAAGLASSAAGLACFVFALAKLLTLQEDNGQLSAIARRGSGSACRSLYGGFVKWIMGKEENGSDSIAVQLADEKHWDDLVIVIAVVSARQKETSSTTGMQDSCKTSMLIQHRAKEVVPKRILQMEDAIEKRDFPSFARLACADSNQFHAVCLDTSPPIFYINDTSHKIISCVEKWNRSVGTPQVAYTFDAGPNAVLIARDRKIAALLLRRLLFHFPPHSNTDSNSYVIGDKSILQDVGVQDTKDIESLPPPPEIKDNIPAQKSNGDVSYFICTRPGRGPVLLPDSRALLNPETGLPK
What is the function of this protein?
Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids (By similarity).  Component of the triterpene saponins (e. g.  ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:29378087).  Catalyzes the conversion of mevalonate diphosphate to isopentenyl diphosphate (IPP) (PubMed:29509695).
What are the official names of this protein?
Diphosphomevalonate decarboxylase 1, Mevalonate diphosphate decarboxylase, Mevalonate pyrophosphate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the diphosphomevalonate decarboxylase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: DUT_LEIXX
Sequence: MTDTVDIPIIAKRLPVYAHPGDAGADLCAAEAVTLEPGERHTVPTGVSIALPEGYAAFVVPRSGLAMKHGLTIVNAPGTVDAGYRGEIRVTVLNTDRSMPYDIAVGDRIAQLIVMPVTRAVFVPVDTLPDSHRGTAGFGSSGYTVTQAGEHA
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: ART5_YEAST
Sequence: MFSLSSLSSSGGHSEQKERERISYFDIRINSPYKDIILIQGSPLELSSIPLSGNLVISVKNEIVVKKISLRLVGRFKLEFLQVGRYKKNSSSLASLVKEKRKIFECYWDNLLVSSKGDVLVGGENAENQHNSSSGRSTSNQDMDTSGNAIFLSKRSLSSPVFNKIIRRKTHSSHRKILELPENGVTGTPFEGLRENARSRSSSSNTLNNNSHSYSNRDGSGSSYLFLMKRGNYELPFNTMLPPEVCETIEGLQSGSILYSFEAIIDGRQLWDTDLSVHTSPHGPIGSTSTSGNGMRTKNKIIIKKFKYLRILRTLSMDNLAMQEEISVGNTWRDKLQYETSIPSRAVPIGSTTPVKIKIFPFEKNIRLDRIEMALIQYYAMKDSSAQIYDDEIAVMKITHLADFGPLTDKLDVDCPFTIPDNLKQITQDCCLQDNLIRVMHKLQVRILLQRQVDGEYKNLEIKAQLPMLLFISPHLPMKGRLVLFDKHDGKIHFRPGELVPLFLTTYPAQGLTPGVELNSTTTAHLALPQPPPNYHESTNDHLMPALQPLGADSVVLTVPSYEQAQAQASASSYVTGSVPAYCDDD
What is the function of this protein?
May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.
What are the official names of this protein?
Arrestin-related trafficking adapter 5.
What is the protein family that this protein belongs to?
Belongs to the arrestin family.
Protein: TPIS_ALKMQ
Sequence: MRKPIIAGNWKMNKTVAETLQFINEIRDQAETTDVEVVLCCPFTALSEAKKALGASKIKLGAQNMHWEDNGAFTGEISAEMLKELGVDYILIGHSERRQYFNETDETVNKKIKKALEQKLMPILCVGETLQEREAAQTFDVIKNQITIDLEGILPDSMKDIVIAYEPIWAIGTGKTASSQDANHVIAYIRQLIQEKYDDGISETVRIQYGGSVKPENATEIMNEEDIDGALVGGASLKADAFLGIVNF
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURNU_MYCLE
Sequence: MGGFADTGQVSVRIRWVITMRAGGVLVSPFDFLDLGDHVGDDPDCGGHLSRAWLVAAIGLGVDRVVWMSQVHGDRVKVVHEPCDAVVDNTDALVTRTSQPALPVVTIHCVPVLLSDARPGVTAAVHVGEGRGSARCASPCDGYDAGPGCVRWRRDIAVLLGPAVSGRNYEVPVVIADGVEAASPDSCTTTRISAGTPGLDLRTGIACQFRDLGVMSIEDDPRRTVADRALFSHLQTVSTGRLASLVWME
What is the function of this protein?
Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine.  Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate.  Also has adenosine deaminase activity.
What are the official names of this protein?
Purine nucleoside phosphorylase ML0918, Adenosine deaminase ML0918, S-methyl-5'-thioadenosine phosphorylase ML0918.
What is the protein family that this protein belongs to?
Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
Protein: RHP16_SCHPO
Sequence: MGTSCNKINSNSNKGKENMHFVLDDNGDSKGNASNQQVERDDKLDMETTRWNGKEFEEPLSTNKKLIIQSNNTSSQHSTPPLSISDTSTHTGSSTDNVEANPNTGFSSARKRSLRSSNLKKKFVPLSSPEESNESEFIDDDESDEVASIIDIKEDETFDSKVEIPEAAPSSSTESDEESIPLSYQSKRRRVSARASSSASSSSRTQAKSIPSHERTHYRLIRQHPELEHVWEKLEEEAPREVKQIEQPKELVLNLLPFQREGVYWLKRQEDSSFGGGILADEMGMGKTIQTIALLLSEPRGKPTLVVAPVVAIMQWKEEIDTHTNKALSTYLYYGQARDISGEELSSYDVVLTSYNVIESVYRKERSGFRRKNGVVKEKSLLHQMEFYRIILDEAHGIKSRTCNTARAVCGLRTTRKICLSGTPLQNRIGELFSLLRFLRADPFAYYYCLQCECKSLHWRFSDRSNCDECGHKPMSHTCYFNAEMLKPIQKFGYEGPGKLAFKKVHSLLKHIMLRRTKLERADDLGLPPRVVEVRKDLFNEEEEDVYQSLYMDSKRKFNTYLAEGVVLNNYANIFQLITRMRQMADHPDLVLASKRKTVDIENQENIVCKICDEVAQDAIESRCHHTFCRLCVTEYINAAGDGENVNCPSCFIPLSIDLSAPALEDFSEEKFKNASILNRIDMNSWRSSTKIEALVEELYLLRKKDRTLKSIVFSQFTSMLDLIHWRLRKAGFNCVKLDGGMTPKARAATIEAFSNDINITIFLVSLKAGGVALNLTEASQVFMMDPWWNGAVQWQAMDRIHRIGQKRPIKVITLCIENSIESKIIELQEKKAQMIHATIDQDEKALNQLSVEDMQFLFSN
What is the function of this protein?
Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation.
What are the official names of this protein?
ATP-dependent helicase rhp16, DNA repair protein rhp16, RAD16 homolog.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RSMH_PSEF5
Sequence: MTIDSGFNHITVLLDEAVEALAVRPDGCYLDGTFGRGGHSRLILSKLGPQGRLLGFDKDPQAIATGQALAAEDGRFVVVQRSFAELGSEVAERGLAGKVSGVLLDLGVSSPQLDDPERGFSFLNDGPLDMRMDPTRGISAAQFIATAPVEEIARVFKEYGEERFSGRMARAVVERREIQPFERTADLAEVLKVANPAWEKGKNPATRAFQGLRIHVNNELGDLEAGLEAALESLEVGGRLVVISFHSLEDRIVKLFMRRLVKGESDNLPRNLPVRFEAFVPKIKIHGKAQFASEAELKANPRARSAVMRVAEKLR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_STRT2
Sequence: MSVSFENTATNRGVVTFTIGQDKIQPALDQAFNKIKKNLNVPGFRKGHIPRAVFNQKFGEEALYDDALNAILPAAYEAAIAELGLDVVAQPKIDVKSIGKGQDWTLTAEVVTKPEVKLGAYKDLEVSVEVSKEVTDEEVDAKLENERKNLAELIVKDGAAEYGDTVVIDFVGSVDGVEFDGGKGENHSLELGSGQFIPGFEDQLVGAKSGDEVEVKVTFPEDYQATDLAGKAAVFVTKVNEVKAKEVPALDDELAKDLDDEVDTLDELKAKYRKELEAAKEIAFDDAVEGAALDLAVENAEIVELPAEMVENEVHRAMNEFMGNLQRQGISPEMYFQITGTTQEDLRKQYEADSDKRVKTNLVIEAVAAAEGFDATDEEIQKEINDLAAEYNMEVSQVSELLSPEMLKHDIAMKKAVEVITSSAKVK
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: O16E_CONCL
Sequence: MKLTTVLIVAVLVLAACQFTVTDNSGDDTENPSLRSAGENQNPDSTKTITARATRARTNMRRGLSRPSKGCIGGGDPCEFHRGYTCCSEHCIIWVCA
What is the function of this protein?
Probable neurotoxin with unknown target.  Possibly targets ion channels.
What are the official names of this protein?
Conotoxin Cal6.1e, Conotoxin Cl6.3.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TAFCL_ARATH
Sequence: MAEPIPSSSLSPKSLQSPNPMEPSPASSTPLPSSSSQQQQLMTAPISNSVNSAASPAMTVTTTEGIVIQNNSQPNISSPNPTSSNPPIGAQIPSPSPLSHPSSSLDQQTQTQQLVQQTQQLPQQQQQIMQQISSSPIPQLSPQQQQILQQQHMTSQQIPMSSYQIAQSLQRSPSLSRLSQIQQQQQQQQHQGQYGNVLRQQAGLYGTMNFGGSGSVQQSQQNQQMVNPNMSRAALVGQSGHLPMLNGAAGAAQMNIQPQLLAASPRQKSGMVQGSQFHPGSSGQQLQGMQAMGMMGSLNLTSQMRGNPALYAQQRINPGQMRQQLSQQNALTSPQVQNLQRTSSLAFMNPQLSGLAQNGQAGMMQNSLSQQQWLKQMSGITSPNSFRLQPSQRQALLLQQQQQQLSSPQLHQSSMSLNQQQISQIIQQQQQQSQLGQSQMNQSHSQQQLQQMQQQLQQQPQQQMQQQQQQQQQMQINQQQPSPRMLSHAGQKSVSLTGSQPEATQSGTTTPGGSSSQGTEATNQLLGKRKIQDLVSQVDVHAKLDPDVEDLLLEVADDFIDSVTSFACSLAKHRKSSVLEPKDILLHLEKNLHLTIPGFSSEDKRQTKTVPTDLHKKRLAMVRALLESSKPETNASNSKETMRQAMVNPNGPNHLLRPSQSSEQLVSQTSGPHILQHMTRY
What is the function of this protein?
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.  Required for the expression of a subset of ethylene-responsive genes (By similarity).  Involved in the negative regulation of cytokinin sensitivity.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 12b, Protein CYTOKININ-HYPERSENSITIVE 1, Protein ENHANCED ETHYLENE RESPONSE 4, TBP-associated factor 12b, AtTAF12b.
What is the protein family that this protein belongs to?
Belongs to the TAF12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KI26B_MOUSE
Sequence: MNSVAGNKERLAVSTRGKKYGVNEMCSPTKPSAPCSPESWYRKAYEESRAGSRPTPEGAGSALGSSGTPSPGSGTSSPSSFTGSPGPASPGIGTSSPGSLGGSPGFGTGSPGSGSGGGSSPGSDRGVWCENCNARLVELKRQALKLLLPGPLPGKDPAFSAVIHDKLQVPNTIRKSWNDRDNRCDICATHLNQLKQEAIQMVLTLEQAAGSEHYDTSLGSPPPISSIPTLVGSRHMGGLQQPREWAFVPAPYATSTYTGLVNKHSGKPNSLGVSNGAEKKSGSPTHQAKVSLQMATSPSNGNILNSVAIQAHQYLDGTWSLSRTNGVTLYPYQISQLMTETGREGLTESALNRYNADKPAASSVPAPQGSCVASETSTGTSVAASFFARAAQKLNLSSKKKKHRPSTPSVAEAPLFATSFSGILQTSPPPAPPCLLRAVNKVKDTPGMGKVKVMLRICSTSARDTSESSSFLKVDPRKKQITLYDPLTCGGQNAFQKRSSQVPPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGRDDSMQNLGIIPCAISWLFKLINERKEKTGARFSVRISAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPICGTQLQNQSELRAPTAEKAAFFLDAAIASRRSNQQDCDEDDHRNSHMLFTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSCVKALSKNREGGSGLCLSLSALGNVILALVNGSKHIPYKESKLTMLLRESLGNVNCRTTMIAHISAAASSYAETLSTIQIASRVLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHARAPVDPEFPLAPLSSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTRGDSRPGEAAEAAASKSERDCLKCNTFAELQERLDCIDGSEEPSKFPFEELPIQFGPEQAGRCAPLSQAVGPDTPSESEKEDNGSDNGQLTEREGTELPASKAQRNRSPAPTVTRSSSPSPASPRSIPGSSSQHSTSQLTQSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYKPPSSPSQRCKVYTQKGVLPSSAPPPSLSKDSGMVSSESLLQPDVRTPPVGMSPQVLKKSMSAGSEGFPGTLVDGEDQEGPPADSKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISGVLDSGRPTSIISFNSDCSVQALASGSRPVSIISSISEDLECYSSMAPVSEVSITQFLPLPKLGLDEKARDAGSRRSSISSWLSEMSAGSDGEQSCHSFIAQTCFGHGEAMAEPPASEFVSSIQNTAVVCREKPEVGPDNLLILSEMGEESGNKAAPIKGCKISTVGKAMVTISNTASLSSCEGYIPMKTNITVYPCIAMSPRNVQEPESSTATPKVSPKASQAQESKEPSTRREMKFEDPWLKREEEVKRENAYSSEEGVKCEPLPSSLKTEGKSEQELDGRPSSGNRLSSSSSEAAAFQGTDNVRRVVDGCEMALPGLVAQSPLHVNRNLKSSSLPRAFQKADRHEELDSFYHCLADSNGFSAASGIPSSKTTLERKVASPKHCVLARPKGTPPLPPVRKSSLDQKNRASPQHGGGSSNTSSPLNQPATFLACFPDESNGKTKDVSSSSKLFSAKLEQLASRSNSLGRTTVSHYECLSLERAESLSSVSSRMHAGKDSTMPRTGRSLGRSTGASPPSCGITQSTGASPKASQSKISAVSKLLLASPKSRSSLSTSTTKTLSFSTKSLPQSVGQSSNLPPSGKHMSWSTQSLSRNRGSGLASKLPLRAVNGRISELLQGSAGPRSAQLRAEAEERSGAPSEDKPAAAHLLPSPYSKITPPRKPHRCSSGHGSDNSSVLSGELPPAMGKTALFYHSGGSSGYESMMRDSEATGSASSAQDSMSENSSSVGGRCRSLKNQKKRSNSGSQRRRLIPALSLDTPSPVRKTASSTGVRWVDGPLRSTQRSLGEPFEIKVYEIDDVERLQRRRGATSKEVMCFNAKLKILEHRQQRIAEVRAKYEWLMKELEATKQYLMLDPNKWLREFDLEQVLQLDSLEYLEALEGVTERLESRVNFCKAHLMMITCFDITSRRR
What is the function of this protein?
Essential for embryonic kidney development.  Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10.  This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction.  Although it seems to lack ATPase activity it is constitutively associated with microtubules.
What are the official names of this protein?
Kinesin-like protein KIF26B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton.
Protein: RF1_EXISA
Sequence: MFDRLSVLEDRYMQLNEMLADPEVLSDSTKLRQYSKEQAQLEETVQMYRQYKETSQAFKEAKSMLEDRTLDAEMRELAKEEMNLLEPEVKELEAKLRILLLPKDPNDEKNVIVEVRGAAGGDEAALFAGDLYKMYTRFAERQNWKVELIDANYTELGGFKEVTFMINGAGAYSKLKFENGAHRVQRVPSTESGGRIHTSTATVAVLPEAEDVEVHIDMKDVRVDTFTSSGPGGQSVNTTQSAVRLTHIPSGLVVSCQDEKSQHKNKDKAMKVLRARLYDKMQSEHMEELSAQRKSAVGTGDRSERIRTYNFPQSRVTDHRIGLTLQKLDRVLAGELEDIIDALIMDEQARLMEDAE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNJB6_PONAB
Sequence: MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFEDFFGNRRGPRGSRSRGTGSFFSAFSGFPSFGSGFSSFDTGFTSFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKMVNGRKITTKRIVENGQERVEVGEDGQLKSLTINGVADDDALAEERMRRGQNALPAQPAGLRPPKPPRPASLLRHAPHCLSEEEGEQDRPRAPGPWDPLASAAGLKEGGKRKKQKQREESKKKKSTKGNH
What is the function of this protein?
Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70.  Plays an indispensable role in the organization of KRT8/KRT18 filaments.  Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin.  Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins.  Also reduces cellular toxicity and caspase-3 activity.
What are the official names of this protein?
DnaJ homolog subfamily B member 6.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
Protein: URED_RHILV
Sequence: MTTVAASTRPQRAEGRGHLAAKLFDGRTRIRELYQEGAAKIRLPDTFDASMEAVIINTAGGLTGGDRMDWSVDAGAGTRIDVTTQACEKIYKASAGTAEVTTSIEVGAQARVDWLPQETILFDRAALSRRLDVDLDEDSEFLAVEAVLLGRKAMGETVETGLFRDRWRIRRSGRLIHAEELRLSDGVAALAARQAVLGGQVAFATLLYAGPLSEAYLGKVRPLVEGSMGGASAWDGKLVVRLAAADGFSLRKILIPVISALRNGAPVPKVWNL
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRYB1_RAT
Sequence: MLKLLLLTLPLLSSLVHAAPSLAMPREGIVGGQEASGNKWPWQVSLRVNDTYWMHFCGGSLIHPQWVLTAAHCVGPNKADPNKLRVQLRKQYLYYHDHLLTVSQIISHPDFYIAQDGADIALLKLTNPVNITSNVHTVSLPPASETFPSGTLCWVTGWGNINNDVSLPPPFPLEEVQVPIVENRLCDLKYHKGLNTGDNVHIVRDDMLCAGNEGHDSCQGDSGGPLVCKVEDTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIYRYVPKYF
What is the function of this protein?
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.  May play a role in innate immunity (By similarity).
What are the official names of this protein?
Tryptase, Mast cell protease 7, rMCP-7, Tryptase alpha/beta-1, Tryptase, skin.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Tryptase subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Released from the secretory granules upon mast cell activation.
Protein: SPIN1_PONAB
Sequence: MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
What is the function of this protein?
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2.  In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway.  Overexpression induces metaphase arrest and chromosomal instability.  Localizes to active rDNA loci and promotes the expression of rRNA genes.  May play a role in cell-cycle regulation during the transition from gamete to embryo.  Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
What are the official names of this protein?
Spindlin-1, Spindlin1.
What is the protein family that this protein belongs to?
Belongs to the SPIN/STSY family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: GLND_LEGPA
Sequence: MKNDNRIIKNTIKQFKEKLCKDFSQKANITSITRKLAVFIDTILIQLFIKNKLHFGDNFCLLALGSYGRRELQLHSDIDLLILHTEKVSNIQLQRAQKFIQDCWDVGLEVSHQITTVSSCANLASQDLSVISTIMDMFLLCGHGALMEELIYQTHTLHMWPSHQYFFAKLQEQQNRYAKYGETAYNLEPNIKNGPGGLRDLQILLSISKRHFKIKKLAEGIGYGFITDKEYEELKYCQNFLWRVRFALHMLAGKPEERLSFDYQVKLAQFFGYQDQSHILAIEQFMKDYFKVIKRNRELNEMLLQWFNETIVYHQKQKIIRLDDEFQLSNRFIEVRNNRVFKQNPQSILKLFYWLVKRPDIEGVRASTIRLIRESLFLMGKRFRESKETANIFINIFRTGNDPYDALQRMNRYGVLAHYLDCFATVTGQMQYDLFHAYTVDQHTLFVIRNISRFKKNEYAKQFPLCAKIISALEKPEILYLGALFHDIAKGRGGDHSELGAIEAQQFTQRHYMEAEDSKLIVWLVRYHLLMSQTAQRKDIYDPKTIEQFCQLLPHARYLDYLYLLTVADICGTNPTLWNAWKDSLLKELYHAAKTRLHKQQELLDEAALISIRKQYAMDILISDGISSRVIQDLWSQFKGKYFLHESPEVIARHTKAILNSKQFPVVIIMPHHSQGGTEVFIYMPHKDERFTITTSVLSNHHVTIQEAAIITCDNQFDLDTYIILDENNQAFLNEQRARDIQKSLCDHLANTGRLPAVSRRRLSRALTHFNVKTQINFIDDNTNHQTQLFLVTNDRPGLLATISRVFLTLNIHLHNAKIATAGERVEDMFYISNQTGYSLNHEEKTILKEKLILEISKSKY
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: GRP_PELRI
Sequence: GSHWAVGHLM
What is the function of this protein?
Stimulates the release of gastrin and other gastrointestinal hormones.
What are the official names of this protein?
Neuromedin-C.
What is the protein family that this protein belongs to?
Belongs to the bombesin/neuromedin-B/ranatensin family.
What are the subcellular locations of this protein?
Secreted. Cytoplasmic vesicle, secretory vesicle lumen.
Protein: TGT_LYSSC
Sequence: MTQPAIRYELLHTCKQTGARLGIVHTPHGSFETPAFMPVGTQATVKTMSPEELKEMNAGIILSNTYHLWLRPGNDIVKEAGGLHKFMNWDRPILTDSGGFQVFSLSQFRKIEEEGVHFRNHLNGDKLFLSPEKAMEIQNDLGSDIMMAFDECPPYPATHEYMLQSVDRTTRWAKRCKEAHSRPEEQGLFGIIQGGEYEDLRRRSAEALVELDFPGYAIGGLSVGEPKDIMNRVLEFTTPLMPANKPRYLMGVGSPDSLIDGAIRGVDMFDCVLPTRIARNGTLMTSEGRLVVKNAKYARDFGPIDPNCDCYTCKNYSRAYIRHLIRTEETFGIRLTSYHNLHFLLKLMEQVREAIRQDRLGDFREEFFEKYGFNGPNAKNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: 1433E_DROME
Sequence: MTERENNVYKAKLAEQAERYDEMVEAMKKVASMDVELTVEERNLLSVAYKNVIGARRASWRIITSIEQKEENKGAEEKLEMIKTYRGQVEKELRDICSDILNVLEKHLIPCATSGESKVFYYKMKGDYHRYLAEFATGSDRKDAAENSLIAYKAASDIAMNDLPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQAEEVDPNAGDGEPKEQIQDVEDQDVS
What is the function of this protein?
Positively regulates Ras-mediated pathways.  Acts downstream or parallel to Raf, but upstream of nuclear factors in Ras signaling.  Three mutants have been isolated, that suppress the rough eye phenotype caused by mutated Ras1 (sev-Ras1 v12).  Inhibits yki activity by restricting its nuclear localization.  Together with pav, has a role in the inhibition of microtubule sliding during neurite outgrowth (PubMed:32022690).
What are the official names of this protein?
14-3-3 protein epsilon, Suppressor of Ras1 3-9.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
Protein: UPP_BIFAA
Sequence: MDIHVLNHPLVDHKLTVLRDKNTPSSTFRELVSELVMLEAYEATRDIEVVDKPIETPVAPMIGKHIAAPAPIIVPVLRAGLGMLDGMTKMIPSAEVGFLGMKRDEENPTQQITYANRLPEDLTGRQCFLIDPMLATGGTLVAATHYLAERGAKDITAVCILGAPEGLKFVEENLDPSIKFKLVLCAVDEKLNDKCYIVPGLGDAGDRLYGVID
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.