PharMolix/UniProtQA huggingface dataset:
Protein: SMS1_CHICK
Sequence: MSGRMKEVVSWSPEEVTNWLMENAVPEYCEPLKSFTGQDLINLTEEDFKKTPLSRVSSDSGQQLLHMIETLKMAHHIEAHKNGHVNGHIHVSVNNTAHENGFSSKTKLNGVPNGYKKEMIKIPMPEPERLQYPMEWGKTFLAFIYALFCFIFTTVTISVVHERVPPKEVQPPLPDAFFDRFDRVQWAFSICEINGMILVGLWLVQWLLLKYKSIISRRFFCIVCTLYLYRCITMYVTTLPVPGMHFKCSPKLFGDWESHLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVILTLTYLFIKEYSPRRLWWYHWLCWTLSMVGMFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEASQTNLLARVWWYKPFQYFEKNVQGIVPRSYHWPFPWPVLHRGRQVKYSRLVNDT
What is the function of this protein?
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide.  The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide.  Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate.  Major form in macrophages.  Required for cell growth in certain cell types.  Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids.  May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide (By similarity).
What are the official names of this protein?
Phosphatidylcholine:ceramide cholinephosphotransferase 1, Protein Mob, Sphingomyelin synthase 1.
What is the protein family that this protein belongs to?
Belongs to the sphingomyelin synthase family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: RBN_ECO7I
Sequence: MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKIFISHLHGDHLFGLPGLLCSRSMSGIVQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEIFDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALNAQALKAAGVPPGPLFQALKAGKTIMLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITMEAKANSRGHSSTRQAATLAREAGVGKLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFTVFNV
What is the function of this protein?
Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.
What are the official names of this protein?
Ribonuclease BN, RNase BN, Ribonuclease Z homolog, RNase Z homolog.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family. RNase BN subfamily.
Protein: GAPN_NICPL
Sequence: MAGNGVFVDIIEGDVFKYYSEGEWKKSASGKSVAIINPTTRKTQYKVQACTQEEVNKVMEVAKTAQKSWAKTPLWKRAELLHKAAAILKEHKAPIAECLVKEIAKPAKDAVTEVVRSGDLVSYTAEEGVRILGEGKFLVSDSFPGNERTKYCLTSKIPLGVILAIPPFNYPVNLAVSKIAPALIAGNSLVLKPPTQGAVACLHMVHCFHLAGFPKGLISCVTGKGSEIGDFLTMHPGVHCISFTGGDTGVAISKKAGMIPLQMELGGKDACIVLEDADLDLAAGSIVKGGFSYSGQRCTAVKVVLVMESVADALVEKVNAKVAKLTVGPPEDDCDITPVVSESSANFIEGLVMDAKQKNATFCQQYKREGNLIWPLLLDNVRPDMRIAWEEPFGPVLPVIRINSVEEGIHHCNASNFGLQGCVFTKDINKAILISDAMETGTVQINSAPARGPDHFPFQGIKDSGIGSQGITNSINMMTKVKTTVINLPTPSYTMG
What is the function of this protein?
Important as a means of generating NADPH for biosynthetic reactions.
What are the official names of this protein?
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase [NADP(+)], Non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase, Triosephosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_ECO27
Sequence: MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTYDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSH1_RAT
Sequence: MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEDNMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAINKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDEEASKASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNRFKISKSRYDSIDSYLSKCGEKYNDIDLTIDTEIYEQLLEEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQERDAVLQGMFYFRKDICKGGNAVVDGCSKAQTSSEPSAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYSLILKCNQIANELCECPELLGSGFRKAKYSGGKSDPSD
What is the function of this protein?
Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
What are the official names of this protein?
Glutamate--cysteine ligase catalytic subunit, GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 3 family.
Protein: FA10_RAT
Sequence: MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEEICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHPPY
What is the function of this protein?
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
What are the official names of this protein?
Coagulation factor X, Stuart factor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MUTS_SALG2
Sequence: MNESFDKDFSNHTPMMQQYLKLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPHHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDGKGYGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMALIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENASRGLCAAGCLLQYVKDTQRTSLPHIRSITMERQQDSIIMDAATRRNLEITQNLAGGVENTLAAVLDCTVTPMGSRMLKRWLHMPVRNTDILRERQQTIGALQDTVSELQPVLRQVGDLERILARLALRTARPRDLARMRHAFQQLPELHAQLETVDSAPVQALRKKMGDFAELRDLLERAIIDAPPVLVRDGGVIAPGYHEELDEWRALADGATDYLDRLEIRERERTGLDTLKVGYNAVHGYYIQISRGQSHLAPINYVRRQTLKNAERYIIPELKEYEDKVLTSKGKALALEKQLYDELFDLLLPHLADLQQSANALAELDVLVNLAERAWTLNYTCPTFTDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITGPNMGGKSTYMRQTALIALLAYIGSYVPAQNVEIGPIDRIFTRVGAADDLASGRSTFMVEMTETANILHNATENSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESISPNAAATQVDGTQMSLLAAPEETSPAVEALENLDPDSLTPRQALEWIYRLKSLV
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: KDPA_RALSO
Sequence: MNAFLLQLAIYLAVLLVLARPLGTYMARVFGDAPSRAHWLRSVERLLYRVAGVDPRAEMGWKHYALAVIAVNVLGALAVYALQRLQPWLPLNPQGFGAVTPDSSFNTAVSFVTNTNWQGYSGESTMSYLTQMLGLAVQNFLSAATGIAVVIALIRGFARHSARTIGNFWVDFTRGTLYVLLPLSVIVAVFFVSQGAIQNFDAYKEVTTVAATTYDNPKTDAQGNPIKDAQGNPVTEKATTQKQTLPMGPIASQEAIKMLGTNGGGPFNANSAHPYENPTPLANFVQMLSIFLIPAALCFTFGAMVGDRRQGWAVLASMTILFVVLAVFEMWAELHANPMLAHLGVDQAVGNMEGKETRFGVVASSLFVTITTAASCGAVNAMHDSLTALGGFVPMFLIQLGEVVFGGVGSGLYGMLVYAILAVFIAGLMIGRTPEYLGKKIEVFEMKMTSIAILVTPLLVLVGTAVAVLASGGRAGIFNPGTHGFSEVLYAFSSAANNNGSAFAGLSANTPFYNVALGIVMWLGRFWIIVPVLAMAGTFAAKKRLPVTVGTLPTHGPLFVVLLIGSVLLVGALTYIPALALGPIAEHLAR
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NU4LM_CALUR
Sequence: MSMVYFNIFLAFIVSLVGLLMYRSHLMSSLLCLEGMMLSLFVMMSVTILNNHFTLASMAPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PLSY_MALP2
Sequence: MNIGNLIGIIILFLFIGYFIGNILFGILISKSQGVDIRTLGSGNVGATNVTRNLGRISGAIVMVLDFFKSWFSTFVCLLIYKALRYSIGDESAYANAGVIIYLGGFAAIIGHCFPCFYFYTLFKTKFNFEEAKKYSGGKGVSSAAGFAASISPWMFFICFVLFWSICLISKYVSLASIVTVFLLPIWSLIPHLNYFYMLDVAQANINPIPPFNRPFEIAAIFNYSLNWWYILVTFLLELLTAVLVIYRHKENIVRLIKGEERKAFAKKTNTH
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBII_ECOLI
Sequence: MQSVDVAIVGGGMVGLAVACGLQGSGLRVAVLEQRVQEPLAANAPPQLRVSAINAASEKLLTRLGVWQDILSRRASCYHGMEVWDKDSFGHISFDDQSMGYSHLGHIVENSVIHYALWNKAHQSSDITLLAPAELQQVAWGENETFLTLKDGSMLTARLVIGADGANSWLRNKADIPLTFWDYQHHALVATIRTEEPHDAVARQVFHGEGILAFLPLSDPHLCSIVWSLSPEEAQRMQQASEDEFNRALNIAFDNRLGLCKVESARQVFPLTGRYARQFASHRLALVGDAAHTIHPLAGQGVNLGFMDAAELIAELKRLHRQGKDIGQYIYLRRYERSRKHSAALMLAGMQGFRDLFSGTNPAKKLLRDIGLKLADTLPGVKPQLIRQAMGLNDLPEWLR
What is the function of this protein?
FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
2-octaprenylphenol hydroxylase, 2-polyprenylphenol 6-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the UbiH/COQ6 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CARB_METPE
Sequence: MPRRTDIKKVLLIGSGPIQIGQAAEFDFSGSQACKSLREEGIEVVLVNSNPATIQTDPETADTIYIEPLRASIIAKIIEKEKPDGILSGMGGQTGLNLTAELAELGALRNVEILGTPLEAIYQGEDREKFKALMQKIGEPVPRSMILNRLDQLGEVIEKVGLPVIIRPAYTLGGAGGGIAHTVDELKRIVEIGLQRSRIHQVLIEESVMGWKELEFEVMRDAKDTCVIICSMENVDPMGVHTGESVVVAPILTLRDDEYQMMRSASIKIIRALDVQGGCNIQFAFQDGDYRVIEVNPRVSRSSALASKATGYPIARVAAKIAIGMHLDEITNAVTGCTPASFEPSIDYVVVKVPRWPFDKFTRADRTLTTAMKSTGEVMAIGRTLEEGFKKALRSIDTDINTHTNHNEIRMILTSPTDERFGCIFDAFREGFTVDEIASLTSINPFFLHKMENIVKIERTLATEPTDLRIQEAAAAGFSMKEIAELTGRPVDEVRTAAGDPVYKMVDTCAAEFPATTPYYYSTHGVTTDIIQNDKKKVLILGSGPIRIGQGIEFDYCTVHAVKALREEGVEVHIVNNNPETVSTDFDTSDQLFFEPMQLEDVVNILKTDDYFGVMVQFGGQNAVNLALPLLQEIKKLGLPTAILGSSPDAMDIAEDRDRFSELLDALKIPSPPNSSAYSEEAALAMANKIGFPVLVRPSYVLGGRAMEIVHDNFELESYMKEAMRVSKSHPVLIDSFLQEAIELDVDAVCDGDEVLIGGIMEHIEEAGVHSGDSACVIPTQSLSDSVLARVREYTKKIAMGLGVVGLVNIQLAVKDDIVYVLEANPRASRTVPFVSKATGIPLAKVAAKVMIGKKLKDLGYKERTFRHVAVKEVLLPFNKLPGVDTVLGPEMKSTGEVMGIDYDFGRAYYKACISADNELPIEGNVFISVSTEQKEEVRRIAAQLRDLGLTLFGTKGTVETLMQAGIEANLVRKVQEGSPNVIDMVRKGEIRLIINTPVDKQSRLDHYQIMRAAVDYGIPYITTLQAARAAALAIDAIKREKITLEPISHYLSEVE
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: UPPP_DINSH
Sequence: MTLFHLILVAVIQGLTEFLPVSSSGHLILLPELSGMADQGQVIDVAVHVGTLFAVVLYFRADVAVAVAGVGRLIRGRIDTPGAFLALCLLIATVPVMVVGLALNLTGLDQALRSMAVIGWTMLIFGIVLYWADQRGPVTRKAGAWTLRHAAIMGLWQALALIPGTSRSGITITGARLLGYGREDAAKLSMLMSIPTILASGGLLGVEVAAQADWALLKDAAIGAVFAFGAALLALTLMMRLLRTVSFTPYVIYRVCLGTILLIIAYS
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYH_SALPC
Sequence: MAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERPQKGRYRQFHQLGAEVFGLQGPDIDAELIMLTARWWRALGIAEHVSLELNSIGSLEARANYRDALVAFLEQHQETLDEDCKRRMYTNPLRVLDSKNPDVQALLNDAPALGDYLDDDSREHFAGLCKLLDAAGIAYTVNQRLVRGLDYYNRTVFEWVTNSLGSQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNPEFIASPVVDIYLVAAGAQTQSAAMTLAERLRDEMPGVKLMTNHGGGNFKKQFARADKWGARIALVLGESEVADGTVVVKDLRSGEQTAVAQDSVAAHLRTLLG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMU_PHOLL
Sequence: MSNSAKSVVILAAGKGTRMYSDLPKVLHLLAGKPMVQHVIDTAMALGAKNVHLVYGHGGDLIEQTLSDQTLNWVLQAEQLGTGHAMQQAAPHFAGDEDILILYGDVPLIGADTLERLLAVKPEGGIGLLTAILDNPTGYGRIVRENGEVTGIIEQKDATEEQRKINEINTGILVANGSDLKRWLSQLDNNNVQGEYYLTDVIALAYKEGRKIEAVHPTRLSEMEGVNNRLQLSALERIYQSEQAEQLLLAGVMLLDPARFDLRGTLIHGRDVVIDTNVIIEGNVTLGNNVQIGTGCVLKNCIIGDDSIISPYTIVEDSEMETGCTVGPFARLRPGSKLAEKAHVGNFVEMKKSYLGKGSKAGHLTYLGDADIGRDVNIGAGTITCNYDGANKFKTIIGDNVFVGSDTQLVAPVIVAKGATIGAGTTVTKNIAENELVVSRTKQTHIQGWKRPVKEKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_CALS4
Sequence: MEELEKDKIERNEEMSEEVKGEGPPSELEQSEEVVEEKIETEVEQKKEPSLEEIVEELRKKLEEKEKEAKEYLDIAQRIKAEFDNYRKRTEKEKAEMISYGQEQVIIELLPVIDNFERALANEGDYNSLREGLELIYRQFKKVLDKFEVREIEAEGQMFDPYKHHALAQEEVEGKQPNEIIEVFQKGYYLKDKVIRPSLVKVAK
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRC_RUMCH
Sequence: MKLLIKNGHVLDVKTGLDRVTDILAVDGIIHEVGSKIDEAGCEVIDATGLYVTPGLVDAHCHLRDPGYEYKEDIESGTRSAAKGGFTSVACMPNTNPVLDNEAMVKYVINKAKTDGFLNVFPIGALSKGLKGEELSEIGELKFAGAVALSDDGRPVGNSSLMKKAMQYASMFDITIISHCEDLDLVDEGLMNEGYQSSILGLKGNPAPAEEVMIARDLILAEYTKATIHIAHVSTELGVDLIRNAKRRGVKVTAETCPHYFTLTDNACEGFNTNAKVNPPLRTQKDVDAIIQGLKDGTIDIISTDHAPHHIDEKNVEFKIAANGMVGFETAFPLAVTYLVKPGHLSLKELVYKMSFNPSQMLGLNKGTIEVGKLADLIIFDLNEEYKVNITEFESKSKNSPFNGLLLYGQPQYTIVGGTPVVRKKVLL
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: IQCAL_MOUSE
Sequence: MSEGTYQRLWEASHVTLEEVLEKEPSVLEPVPSRERQSFQYRISVLYLYYLGLLRRFNLAYDQMVQPQKRRLLRRLLDGVAGRVLELKDELVRVDLCETHCLDRVLQDLKLTPADLEVPIPKYFQLEQSSAVKARQQMLADILNRLEPLVSQENLRGLSRTAALILVQSAERARQGRLRATFMREIRKEEERDRRIWENGQQKFSRDQGAIVIQKVWKGYLQRKRIEQDRRVEMEFIGMLPSPNQTARLNTLNQAFLGEESRRMRQVEKEEEFQEAIGKTYESLTETEGPDMKERMKDQIRQWFIECHALTGRFPDYPDEASGGSYLIFADKTPEQVRLDLEAQAQESRKKDQEKKEKNKEKEKEKKEKKKKKVKEEKVKKEPEVMFRVLPSKSIPVINAGHEEYTSVWKSRYDNKHPSQNFDSETLREEKRKQVEMEIRVQVDELMRQELKNLRLAVDREETRPLKSPKKKGGKKSGKKKKEKDLTPDRSVDSLFEELVIIGLIKKSALVTLSDYIGDCLYLGSTLTLANKMPMPSLFDIRQNMALYGVLRLGSHDIHTMAPLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPDNLMGKYPGKNGAQLLVHIVFKVARLLQPSVIWIGNTEKTFYKKVPKEERTMDPKRIKKDLMRATKQLSPGDRVMLIGTTERPQLAEMKGLCRFYERILFIPRPDYASRYVLWKRMIESQGRGVQLTSSLDVSALARVSDGYTPSHILQSIQSVLTERRLLQLIKKPLVASEFVGHLARLDPVYREEEESLKEWFFKTPLGKKNMKFTKDQLEAEEARLTKEKKKKK
What are the official names of this protein?
IQ and AAA domain-containing protein 1-like, Protein IQCA1P1.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: Y5390_ARATH
Sequence: MACVSTCLILSPRLTQVGLSSKKPFLIRLRSPVDRYSFPRMLTERCLSTRRKFNRHGIAVVKAASLDKVSGAIKPGGLVESDKLPTDVRKRAMDAVDECGRRVTVGDVASRGGLKVTEAQTALQAIAADTDGFLEVSDEGDVLYVFPRDYRTKLAAKSLRIQIEPFLEKAKGAVDYLARVSFGTALIASIVIVYTSIIALLSSKSEDDNRQRRRGRSYDSGFNFYINPVDLLWYWDPNYYNRRRAREDEGKGMNFIESVFSFVFGDGDPNQGIEEERWQMIGQYITSRGGVVAADELAPYLDVPSSKSAMNDESYILPVLLRFDGQPELDEEGNILYCFPSLQRTASGSSRRKEYVGKWFDWVADMEKFFKEKKWQFSKTSTSERALVIGLGAVNLFGVIVLNTLLNEMSVRPGGFLTFVKNIYPLLQIYAGSFFTIPLIRWFSIKRKNNQIENRNKARLQFARALESPDIALRRKLLSARDMAQKTVIGKDRIVYSTDRDMMEQNYETDEWDRRFKELEKSD
What are the official names of this protein?
Uncharacterized protein At5g03900, chloroplastic.
Protein: LPR4_ORYSJ
Sequence: MMGENRARVVALVVAVVVVVVGVAGNVAAAQAAVTVADLQRVAGSLQMYVDALPQMAKIRGYGFQRGQAVPINLTIGMYQKTWKFHRDLPATPVFVYGQCPDSATFPGPTIMARHDVPLFVRWENHLPASHILPWDPTVPTAIPKNGGVPTVVHLHGSAHPPQSDGSAFAWFTAGFAEKGPAWTQATYRYPNVQPPGNLWYHDHALGLTRANLLAGLLGAYVIEKPEVDTPMDLPCDDDDLHLVIADRSFNVDGSLYMNSTGVAPNIHPQWAPEYFGEAITVNGKAWPFLVVHRRRYRLRILNASNARYFNVSLSNGLPIHVVGSDASYLSAPVTVSNLLLSPAEIFDVVVDFSQSPTAEIELLNSAPYPFPTGAAPGPLNGKVMKFIVQPNGPLDPPDNSTVPDHEVPYASVTALPPTTMTRYIVMYEYLTPTGQSTHLYINGLRLEDPVTETPKSGTTELWQVINLTGDNHPLHIHLGMFQAVKMQQLVNLQAFTDCMTAVNDAVKCNVDQHAVGPVVPVPDHEKTWKNVIKVPPGFVTSVVIAFKLVDTNQTYPFDTTAEPGYVYHCHILDHEDNAMIRPLKLLA
What is the function of this protein?
Multicopper oxidase that may play a role in the maintenance of inorganic phosphate homeostasis.
What are the official names of this protein?
Multicopper oxidase LPR1 homolog 4.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: LPXB_ECOUT
Sequence: MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNGARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQFERIKAAVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
What is the function of this protein?
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Lipid-A-disaccharide synthase.
What is the protein family that this protein belongs to?
Belongs to the LpxB family.
Protein: PSBF_MORIN
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RLMN_CUPMC
Sequence: MNNLVNLLDLDADALTAYCGELGEKPFRARQLQRWIHQFGASHFDAMTDLAKSLREKLATRAEIRSPAAISDHTSSDGTRKWLLDVGAGNAVETVYIPEDTRGTLCVSSQAGCAVNCRFCSTGKQGFSRNLSTGEIIGQLWMAEFAMRAQLGRGPKDERVISNVVMMGMGEPLLNYDAVVPAMRLMLDDNAYGLSRRRVTLSTSGVVPMMDRLSKDLPVALAVSLHASNDALRDVLVPLNRKYPLAELMAACRRYLEFAPRDFITFEYCMLDGVNDGVEHARELLKLVADVPCKFNLIPFNPFPESGLKRSNNEQIRRFAQVLMDAGIVTTIRKTRGDDIDAACGQLAGEVMDRTRLAERGKFGKITPLVPVADAGAPREARPA
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_PORG3
Sequence: MAKINFYAEGVSLPRIRRRIVGKWIAEVCSRYGKAVGEISYLFCDDEYILKANQEFLDHDYYTDIITFDSCEADTVNGDLLISLDTVRSNARALDLRYEDELHRVIIHGILHLCGLKDKSKKDEAQMRAAEEEALVMLQETIGSELSLLHT
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.