PharMolix/UniProtQA huggingface dataset:
Protein: ACCA_BORA1
Sequence: MRNTFLEFEQPLAELENKIEQLRYVQADSAVDISDEIGRLQQKSQTLAKEIYGKLTPWQTALVARHPQRPYTLDYVREIFTDFHELHGDRMYADDQSIVGGLARFNGQSCMVIGHQKGRDTKERAARNFGMPRPEGYRKAQRLMRLAEKFKLPIFTFVDTPGAYPGIGAEERGQSEAIGHNLYVMAELKVPVIVTIIGEGGSGGALAIAVGNAVLMLQYSTYSVISPEGCASILWRSADKAPEAAEALAITAPRLKDLGLIDRVVNEPIGGAHRDPRVMARLLRRALGDSLRQLQDLTPEQLVEQRLERVLAYGRFQEVRG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDP_SHESR
Sequence: MSCLPALDKFLQNYHQSYLSTLGELPRYYPQGEPSLCIQGEFDESSDEAVSWLPVKREQLGSFANVEHALELTLWPDINHFYGEYFAAPVLFDSPWGTGELLQVWNEADFDALQQNIIGHLMMKQKLKQPATWFIGLLDEGDKMLTVDNADGSVWVEIPGELPSTQLAPSLAEFIEALSPRIAPPVKHEELPMPALEHPGIFASFKRMWHNLIGKR
What is the function of this protein?
Interacts with the SecY protein in vivo.  May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
What are the official names of this protein?
Protein Syd.
What is the protein family that this protein belongs to?
Belongs to the Syd family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Protein: RS20_MYCTO
Sequence: MANIKSQQKRNRTNERARLRNKAVKSSLRTAVRAFREAAHAGDKAKAAELLASTNRKLDKAASKGVIHKNQAANKKSALAQALNKL
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: APT_SALEP
Sequence: MTATAQQLEFLKNSIKSIQDYPKPGILFRDVTSLLEDPKAYALSIELLVERYKNAGITKVVGTEARGFLFGAPVALGLGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDNVLVVDDLLATGGTIEATVKLIRRLGGKVTDAAFIINLFDLGGEQRLEKQGITCYSLVPFPGH
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LUTB_BACVZ
Sequence: MAMKIGTAAFKERVSEGIDNEFMRGAVSGAQERLRTRRLQAAEELGNWEDWRSHAEEIRQHVLDNLDFYLEQLAENVANRGGHVFFAETAEEASSYIRDVIRQKNAKKIVKSKSMVTEEINMNEVLEEEGCEVTETDLGEYILQIDDHDPPSHIVAPALHKNKEQIRDVFKERLEYKQTEKPEELVMHARSVLRKKFLEADVGITGCNFAIADTGSVSLVTNEGNGRLVSALPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALTGPRQQGEADGPEEFHLVVVDNGRSRILGTEFQSVLQCIRCAACINVCPVYRHVGGHSYGSIYSGPIGAVLSPLLGGYDEYKELPYASSLCAACTEACPVKIPLHELLLKHRQNIVEKEGKAPISEKLAMKAFGLGSSSPSLYKMGSKWAPAAMTPFTEDDKISKGPGPLKEWTAIRDFPAPHKSRFRDWFKDREKQKGEE
What is the function of this protein?
Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.  Has probably a role as an electron transporter during oxidation of L-lactate.
What are the official names of this protein?
Lactate utilization protein B.
What is the protein family that this protein belongs to?
Belongs to the LutB/YkgF family.
Protein: GPIX_HUMAN
Sequence: MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD
What is the function of this protein?
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels.  The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.  GP-IX may provide for membrane insertion and orientation of GP-Ib.
What are the official names of this protein?
Platelet glycoprotein IX, GP-IX, GPIX, Glycoprotein 9.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: THIQ_SALPA
Sequence: MLKLIDITWLYHHLPMRFTLAVERGEQVAILGPSGAGKSTLLNLIAGFLAPASGTLLIAGEDHTLTPPSRRPVSMLFQENNLFSHLNVQQNIGLGLNPGLTLNASQREKRDAIARQMGIESLMTRLPGELSGGQRQRVALARCLVREQPVLLLDEPFSALDPALRQEMLTLVSDICRERQLTLLMVSHSVEDAARIAPRSIVVADGRIAWQGKTDELLSGQASASALLGIKSHIL
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Thiamine import ATP-binding protein ThiQ.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SYG_BORGP
Sequence: MVRMEDIISLAKRKGFVFQSSEVYGGLSGAWDYGPLGVELKKNIKSEWWKSMVYLHENIVGLDSAIFMRPEIWRASGHIDGFSDSMVDCKDCKSRFRADFIDLSKNCPNCKVGNNFTSPRSFNLMFKTHIGVVEDSSSEIYLRPETAQGIFVNFRNVLDSSRLKIPFGIAQVGKAFRNEIVTKNFIFRTCEFEQMEMQFFVHPKQIDEWFCYWQQNRMNFFIETLKIRPDKLRFKAHDSTQLAHYAKSAFDIEYEFPFGFQEVEGIHNRGNYDLTQHSKFSNNPKIFEYHDLLTKERYVPHVIETSAGLTRSVLMTLCNAYSEEELSDGDKRIVLRLHPKLAPYKIAIFPLVKKVELVEIARRIYIELCDDFHIFYDDSGTIGKRYRRQDEIGTPYCVTVDYSTIEDETVTVRERNNMTQKRIFINDLYSYIKTEILNYKEDFNK
What is the function of this protein?
Catalyzes the attachment of glycine to tRNA(Gly).
What are the official names of this protein?
Glycine--tRNA ligase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KA233_SCOTI
Sequence: MKMSIVIILLLFTCLIATNGASGTKCSGSPECVKFCRTKGCRNGKCMNRSCKCYLCS
What is the function of this protein?
This toxin shows both immunosuppressive and anti-inflammatory activities (PubMed:28077339).  It has the potential to inhibit human T cell activation, since it reduces IL-2 secretion and the expression of T cell activation marker CD69 and acts as a anti-inflammatory agent, since it provokes the reduction of secretion of both IFN-gamma and TNF-alpha (PubMed:28077339).  In vivo, the delayed-type hypersensitivity response in rat autoimmune disease model is ameliorated in the presence of this toxin (PubMed:28077339).  Acts by blocking Kv1. 3/KCNA3 potassium channels of T-lymphocytes (By similarity).
What are the official names of this protein?
Potassium channel toxin alpha-KTx 23.3, Toxin St20.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 23 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL17_DELAS
Sequence: MRHGHGLRKLNRTSSHRLAMLKNMMNSLIEHEAIKTTVPKAKELRRVIEPMITLAKVDTVANRRLAFDRLRDRDSVTKLFNELGPRFAKRPGGYTRILKMGFRVGDNAPMAFVELVERAEEGAAEAKAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: GPMA_CYTH3
Sequence: MPILVIVRHGQSEWNLKNLFTGWSDVELTPTGEHEAEYAGIVLRPYHFDIAFTSVLKRAIHTLSIILNQTGATIPIIENEALNERNYGDLQGLNKAEVGEKYGAQQLIAWRRSYTEVPPGGESLENTCQRVIPYYQEKIEPELKDGRNVLIVAHGNSLRALMMHLEKISPEDIAHVDLATGAPRLYEFSSKLDLNSVSYIKLPETPLDVSTLL
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: KHSE_BRUA1
Sequence: MAVYTDINEIELGAFLRHYDIGTLTSYKGIAEGVENSNYLLHTSSGSFILTLYEKRTNREDLPFFLGLMQHLAKRGLECPQPVVRNDGAMIGQLAGRPAAIVTFLEGMWMRRPTVAHCEAVGEGLAHMHLAGADFPMRRRNGLTLPDWRPLWNLSRKCADTVERGLVAETEADLDFLEKNWPADLPQGVIHADLFPDNAFFLGDRLSGFIDFYFACTDILAYDVAVCLNAWCFEKDFSYNRTKGAALLRGYTSVRPLSEAEADALLVLARGAAVRFMLTRLYDWLTVPAGSFVVKKDPMEYVRRMRFHRQIESAAEYGLEMQGVAA
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: NDK_FLAJ1
Sequence: MATNRTFTMIKPDAVANGHIGNILAMITNGGFKIVSLKLTQLTVADAKAFYAVHAERPFYGELVEFMSRGPIVAAILEKDNAVEDFRTLIGATNPAEAAEGTIRKAYATSIGENAVHGSDSDENAAIESAFHFAGREQF
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXA_SALTI
Sequence: MKIITCYKCVPDEQDIAINNADGTLDFSKADSKISQYDLNAIEAACQLKQQLGDAQVVAMSVGGKALTNAKGRKDVLSRGPDELIVVIDDQFEQALPQHTATALAAAAQKSGFDLLICGDGSSDLYAQQVGLLVGEALNIPAINGVSKILSLTDSTLTVERELEDEVETLSIPLPAVIAVSTDINTPQIPSMKAILGAAKKPVQVWSPADIGLNSVPAYSTQQVAAPKQRERQRVVIEGDGEEQIAAFVENLRKII
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixA.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: MEL_SACPA
Sequence: MFNLNFFNYTCHCEWCFWVLPSYNGLGLTPQMGWDNWNTFACNVSEDLLLNTADRISDIGLKDLGYKYVILDDCWSSGRDEDGFLVADEQKFPNGMGHVADRLHNNSFLFGMYSSAGEYTCAGYPGSLGREEEDAQFFANNRVDYLKYDNCYNKGRFGTPESSHKRYKAMSDALNKTGRPIFYSLCNWGQDLTFYWGSDIANSWRMSGDITAEFSRPDSRCPCDGDEYDCKYAGYHCSIMNILNKAAPMGQNGGIGGWNDLDNLEVGVGNLTDDEEKTHFSMWAMVKSPLIIGADVNHLKASSYSIYSQSSVIAINQDPKGIPATRVWRYYVPQTDKYGQGEIQFWSGPLENGDQVIALLNGGMKARPMNATLEDIFFDSYQGSEELSTSWDIYDLWANRIDNATASAILENNKVTNNTLYNATKLSYKEGLLNGDSRLFGTKVGTISPDGIINTTVPAHGIALYRLRSSS
What are the official names of this protein?
Alpha-galactosidase, Alpha-D-galactoside galactohydrolase, MELp, Melibiase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: CMOA_HELPG
Sequence: MKDTLFNQSLNKRFCFDEKVAHVFDDMLERSIPYYYEMLDLGAYFIAQNLKENLNAKPLIYDLGCSTGNFFIALNQQIQQDIELVGIDNSMPMLKKAQEKLKDFKNARFECMDFLEVEFKEASAFSLLFVLQFVRPMQREVLLKKIYNSLALNGVLLVGEKIMSEDRILDKQMIELYYLYKQNQGYSHNEIAFKREALENVLVPYSLKENIALLESVGFKHVEAVFKWVNFTLLAARKT
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: Y2524_GEOSW
Sequence: MAGHSKWKNIQRRKNAQDAKRGKLFMKLAKEIYVAAKTGGGDPASNPALRLVIEKAKAANMPNENIERAIKKATGTQEHTNYEEVRYEGYGPGGVAVMVVCLTDNKNRTASNVRVAFSKNGGNLGETGCVSYLFDRKGLLVIAREGLDIDEDDMLLQAIEAGAEEMETTEDSFEIYTTPEAFEEVKEQLEKNGFTFASAEITMIPQTYTTLAGDDLKKMLKLIDTLEDDDDVQEVYHNLDESVLEE
What are the official names of this protein?
Probable transcriptional regulatory protein GWCH70_2524.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSA4_DROME
Sequence: MARRYDSRTTIFSPEGRLYQVEYAMEAISHAGTCLGILAEDGILLAAECRSTNKLLDSAIPSEKIYRLNDNMVCSVAGITSDANVLTSELRLIAQRYQFSYGEVIPCEQLVSHLCDIKQAYTQYGGKRPFGVSLLYMGWDNKYGYQLYQSDPSGNYGGWKATCIGNNFGAAISMLKQELADKENVKLTLADAKDLAIKVLSMTLDTTKLTPEKVEMATLQRVDNKTVYSVLEKPDVEKLIEKYTKVQAEAEAAKKEKQAKQPTK
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit alpha type-4, PROS-Dm29, Proteasome 29 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RNY_CAMC1
Sequence: MIEVLIGLGAGVVGVGAGYLYAKKINDANYNIFLEQAKAKAKAIEYEAELTLKNSKISVQEAEFEAKKRYDDKTTKLQKEYASKFDELTKKEKILLNEQELLNESKELFEKDKQDAKVTYEEGLNLKATYQNKVEEAIRVLEHAAGLTEEEAKEVVLKKVEEKSRADIAHIVRKYEEEAKREAKKRVNYILAQATSRFAGEFAAERLINVVNIKNDELKGRIIGKEGRNIKTLEMVLGVDIIIDDTPHAIILSSFNLYRRAIATRVIELLVEDGRIQPARIEDLHKKVTEEFEQSIQEEGENIVMDLGLNKIHPEIVKLIGKLKFRASYGQNALAHSLEVAHLAGIIAAECGGDEKLAKRAGILHDIGKALTHEYEGSHVDLGAEICKRYKEHPVVINAIYAHHGHEEATSIESAAVCAADALSAARPGARREVLESFLKRVEEIENIAKSKEGIKQAYAINAGREIRVIANAKLINDDEAVLVAKEIAQEIESKVQYPGEIKVSVIRETRAVDFAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ILVC2_BACAN
Sequence: MKTYYEQDANVGLLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALHVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEGGLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGEELREMMSWIHAPKELVKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)) 2, KARI 2, Acetohydroxy-acid isomeroreductase 2, AHIR 2, Alpha-keto-beta-hydroxylacyl reductoisomerase 2, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: NU4C_POPTR
Sequence: MNSFPWLTIFVGLPISAGFLIFVFPHRGNKVIRWYTIFICVLELLLMTYAFSYYFQLDDPLIQLTESYKWINFFDFYWRLGIDGLSLGPILLTGFITTLATLAARPITRDSRLFHFLMLAMYSGQIGLFSSQNLLLFFIMWELELIPVYLLLAMWGGKQRLYSATKFILYTAGSSVFLLMGALGIAFYASNEPTFNFETSANQSYPVTLEILFYIGFLIAFAVKSPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLVRINMELLSHAHSIFSSWLIIVGAIQIIYAASTSSGQKNLKKRIAYSSVSHMGFTIIGICSISDMGLNGAILQIISHGFIGAALFFLSGTSYDRIRLVYLDEMGGMATLMPKIFMMFSILSLASLALPGMSGFFAELVVFFGIITAKKYFLMPKILITFVTAVGTILTPIYLLSMLRQMFYGYKLFNARNSYFFDSGPRELFVSIAILLPVISIGIYPDFVFSLSVDKVEAILSNYFYS
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: QUEC_SHEB2
Sequence: MSTSLVSKPLASKAVVVFSGGQDSTTCLIQALTQYDEVHGITFDYGQRHREEIEVAKSLAKRLKITSHKVMDVTLLNELAISALTRDAIPVSHELMENGLPNTFVPGRNILFLTLAGIYAYQLGAEAIITGVCETDFSGYPDCRNDFVKAMESALVQGMDKQLKIITPLMWLNKAQTWALADKYQQLDLVRHHTLTCYNGVIGDGCGDCPACHLRKRGLDEYMQDKTAVMASLDASEPKA
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: RS20_BAUCH
Sequence: MANIKSAKKRAVQSEKHRLHNASRRSMVRTFVRKVYNAILTQDKKAAQQAFSAMQPIVDRQASKGLIHKNKAARYKSHLITQINKMH
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: YFIU_BACSU
Sequence: MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFSVSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFPLFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFLLDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYGMTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMFQRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTDKKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEAAKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQMIPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAISIPAFRRQKR
What are the official names of this protein?
Uncharacterized MFS-type transporter YfiU.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GEMI2_RAT
Sequence: MAWVPAESAVEELMPRLLPVEPCDLTEGFDPSVPPRTPQEYLRRVQIEAAQCPDVVVAQIDPKKLKRKQSVNVSLSGCHPAPEGYSPTLQWQQQQVIQFSSVRQSVHKHRNHWKSQQLDSNVTMPKSEDEEGWKKFCLGERLCAEGATGPSTDESPGIDYVQVGFPPLLSIVSRMNQATITSVLEYLSNWFGERDFTPELGRWFYALLACLEKPLLPEAHSLIRQLARRCSEVRLLVGSKDDERVPALNLLICLVSRYFDQRDLADEPS
What is the function of this protein?
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity).  Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity).  In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity).  To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity).  Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity).  Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity).
What are the official names of this protein?
Gem-associated protein 2, Gemin-2, Component of gems 2, Survival of motor neuron protein-interacting protein 1, SMN-interacting protein 1.
What is the protein family that this protein belongs to?
Belongs to the gemin-2 family.
What are the subcellular locations of this protein?
Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm (By similarity).
Protein: CCA_STRSV
Sequence: MRLETLPSEFQEALPVLEKIKAAGFEAYFVGGSVRDALLQRPIHDVDIASSSYPEETKRIFDRTVDVGIEHGTVLVLENNREYEVTTFRTEDVYVDYRRPSKVSFVRSLEEDLKRRDFTINALALDENGQVIDLFQGLDDLENQILRAVGTAAERFNEDALRIMRGFRFQAALDFDLEQDTFAAMKDCAPLLEKISVERIFIEFDKLLLAPFWRKGLEALLTSGAIEFLPDLKGSRAKLERLFDLASDFRFSASEQAWAALLLALDVQNVKGFLKKWKTSREFAKKAEDLVEIAAIRSERDLTKRDCYDYDIDLLLQAEELRQAQGLPVDFSAIQNLDASLTIHNKQEMVVNGGMLMQEFGFEPGPKLGQILKELEHAIVDGCLPNDLEAVYAYIEEKK
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: ENO_TOLAT
Sequence: MSKIVKVIAREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKARFLGKGVLKAVGAVNGPIAAALLGKDAQDQAAIDQIMIDLDGTENKSNFGANAILAVSLANAKAAAAAKGLPLYAHIAELNGTPGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGAEVFHNLAKVLKSKGYNTAVGDEGGFAPNLKSNAEALEVIAEAVAAAGYVLGKDVTLAMDCAASEFYDAEKKEYNLKGEGRIFTSNGFSDFLEDLTTKFPIVSIEDGLDESDWEGFAYQTQKLGKKIQIVGDDLFVTNTKILKRGIDNGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGAKAPFNGLKEVKGQA
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: CA174_MOUSE
Sequence: MRSRKLTGGVRSSARLRARSYSSASLASARDVTSSTSAKTTCLASSSHKATDRRTSKKFKYDKGHLVKAELQKLDPKSDISSLPKVAPVAPCENKFAEDSAEAAVSVPESREPPQGCSTPASEEPSVKAENGLSTEPSSAAAAQEPDDSSAGQAEPVPRTEEVRASVLQMDSSIFLDDDSNQPMPVSRFFGNVELMQDLPPASSSYPSMSRREFRKMHFRAKDDEDDAEG
What are the official names of this protein?
UPF0688 protein C1orf174 homolog.
What is the protein family that this protein belongs to?
Belongs to the UPF0688 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CSA8A_CONRA
Sequence: MMSKMGAMFVLLLLFTLASSQQEGDVQARKTHPKREFQRILLRSGRKCNFDKCKGTGVYNCGESCSCEGLHSCRCTYNIGSMKSGCACICTYY
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.  This toxin provokes a nearly complete and slowly reversible inhibition of both the human adult (alpha-1-beta-1-epsilon-delta (CHRNA1-CHRNB1-CHRND-CHRNE)) and human fetal (alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND)) neuromuscular nAChRs (PubMed:15910004, PubMed:26074268).  It also reversibly blocks the neuromuscular alpha-7/CHRNA7 nAChR, the alpha-3-beta-2 (CHRNA3-CHRNB2) nAChR, the chimeric alpha-6 or -3/beta-3 or -2 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) nAChR and with a low potency the alpha-4-beta-2 (CHRNA4-CHRNB2) nAChR (PubMed:15910004).  In addition, the toxin also inhibits the alpha-9-alpha-10 (CHRNA9-CHRNA10) nAChR with a high potency (IC(50)=187 nM) (PubMed:26074268).
What are the official names of this protein?
Alpha-conotoxin RVIIIA, AlphaS-conotoxin RVIIIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin S superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPF_METAR
Sequence: MTRVKICGTTTPEDALACAVSGADAIGMLVDVRISPRCITADQARLITSVLPPFVASVIVMQPSTPGEVVDAVRKIRPTAVQLHGSEPPDFLKHIKLQVPGVRLIKTIHVGEGGEIEKARQYEGVADAILLDTASARGGGMGITHDWNVSREIIGSVRLPVILAGGLSPKNVAEAIEAARPYAVDVCSGVEAEKRKKDLRLVREFIEQVRVTK
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.