PharMolix/UniProtQA huggingface dataset:
Protein: EIF3C_PHANO
Sequence: MSRFFAASDSSSEESSEEELYSDNEASAQEDSDKDSDDDDSDDDDSSSGSEAGGANRFLKDADSDSESEDEDQNKVLKSAKDKRFDELEATIRLIENAQRINDWAVISDQFDKLNRQAPTLMKQNDGKVPKLYIQAIADLETVVLETHEKQKVTPKKMNAVNTRGFNAVRQKVKKHNREFQKDIDLYRENKDEFMRETEEVEAAPKEKKKKSKIPQLGTEIVDEATDDGFITVGAGGKAVQYTPEGILKHLRAIVEQRGRKNSDKLEHIRTLEKLFDVSVNDYQRIRVLLTLISTRFDLTSGTASHMHQDQWKLADQEFGKLLEILENTKEIVVIENAEEWEDDDKLPPIEEGQIFRIPGSVVSFVERLDDELTRSLQHIDPHTAEYVERLTDEALLYAQLVRALIYVESLKKNASLELPQESLNRVVMRRLEHVYFKPSQVVTIMEANSWKAVPETLDSEVTPRAISNDTTSLVQTLSTYLFQNSEGIIRARAMLCQIYFLALHDQYYKARDMMLMSHLQETISNFDVNTQILFNRALVQVGLCAFRAGLVYESQNSLQEICGSNRQKELLAQGLQMQRYSQISPEQERLERQRQLPFHMHINLELLECVYLTCSMLLEIPLLAQLGSSPDLRKRVISKTYRRLLEYHERQIFTGPPENTRDHVMQASKALSAGEWKKAAEFINSIKIWELVADSEKIKEMLSAQIQEEGLRTYLFTYAPYYDTLAVSTLASMFELSERKVSAVVSKMISHEELAAALDQVNSAIIFRKGVELSRLQTLALSLSDKASGLIESNEKTLEQRTQGTANAFERQGGRGGRGGGRGRGGGRGGGVPRGGRNQQFTGGALGRAIQA
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit C, eIF3c, Eukaryotic translation initiation factor 3 93 kDa subunit homolog, eIF3 p93, Translation initiation factor eIF3, p93 subunit homolog.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit C family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CT31_RANCI
Sequence: DLFQVIKEKLKELTGGVIEGIQGV
What are the official names of this protein?
Citropin-3.1.2.
What are the subcellular locations of this protein?
Secreted.
Protein: ACCD_BARVE
Sequence: MEKSWFNLMFSKGELEYRGELSKAMDSFAPSEKTTISQDRFIYDMDKNFYGWGERSSYSNNVDLLVSSKDIRNFISDDTFFIRDSNKNSYSIYFDIKKQKFEIDNDLSDLEFFFYSYCSSSYLNNRSKGDNDLHYDPYIKDTKYNCTNHINSCIDSYFRSHICIDSHFLSDSKNSNENYIYNFICSESGKIRERKNYKIRTNRNRSNLISSKDFAITQNYNKLWIQCDNCYGLMYKKVKMNVCEQCGHYLKMSSSERIELSIDPGTWNPMDEDMVSADPIKFHSREEPYKNRIDSAQKTTGLTDAVQTGTGQLNGIPVALGVMDFQFMGGSMGSVVGEKITRLIEYATNQCLPLILVCSSGGARMQEGSLSLMQMAKISSVLCDYQSSQKLFYISILTSPTTGGVTASFGMLGDIIIAEPYAYIAFAGKRVIEQTLKKAVPEGSQAAESLLRKGLLDAIVPRNPLKGVLSELFQLHAFFPLTKNSIK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: UBIQP_XENLA
Sequence: QKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG
What is the function of this protein?
Ubiquitin Exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
What are the official names of this protein?
Polyubiquitin.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ASSY_SYNS9
Sequence: MGRAKKVVLAYSGGVDTSVCIPYLKQEWGVEEVITFAADLGQGDELEPIRQKALDAGASQSLVGDLIQPFIEDFAFPAIRANALYEGRYPLSTALARPLIAKRLVEVAREVGADAVAHGCTGKGNDQVRFDVAIASLAPDLKVLTPAREWGMSREETIAYGERFGMPSPVSKKSPYSIDLNLLGRSIEAGPLEDPMVAPPEEVFAMTRSITDAPDAFEEIEIRFESGNPVAINGQSLDPVAMIREANRLAGTHGIGRLDMIENRVVGIKSREIYETPGLLLLIQAHQELESLTLAADVLRSKRQLEMQWSDLVYQGLWFGPLKEALDGFMDRTQEHVNGVVRLRLHKGNATVIGRGSSDSSLYVPEMASYGSEDQFDHRAAEGFIYVWGLPIRLWAASKRSSR
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SRP54_GEOCY
Sequence: MVLADLGRKITTALLPRQRTVINEEVLQAMLKEICTALLEADVNVKLVGKLRQNVRAAIDFEDMGAGLSKRRIIQTSVFNELCKLLDPGVPVWHPTKGHSNVIMFVGLQGSGKTTTCTKLAYHYQKKGWKTCLVCADTFRAGAFDQLKQNATKARVPFYGSYTEMDPVVIAQEGVEKFKEDSFEVIIVDTSGRHKQEESLFEEMLQVSQAIDPDNIIFVMDGTIGQACESQARAFKEKVDVASVIVTKLDGHAKGGGALSAVAATRSPIIFIGTGEHIDEMEPFKTKPFVSKLLGMGDLEGLMEKVSDLKLDENEELMDKLKHGQFTLRDMYEQFQNIMKMGPFNQIIGMIPGFSPDFMSKGNERESMAKLKRLMTMMDSMNDGELDHPNGAKLFSKQPGRAARVARGSGTSVREVNELLKQYSNFSATVKKMGGIKGLFKGGDLGKNVNPSQMAKLNQQMAKMMDPRVLQQMGGMSGLQNMMRQFQQGASNMPGFKGK
What is the function of this protein?
Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity).  As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity).  Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity).  Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity).  Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity).  SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity).  Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity).
What are the official names of this protein?
Signal recognition particle subunit SRP54, Signal recognition particle 54 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the GTP-binding SRP family. SRP54 subfamily.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm. Endoplasmic reticulum.
Protein: CXA1_RAT
Sequence: MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
What is the function of this protein?
Gap junction protein that acts as a regulator of bladder capacity.  A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).  May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016).  Plays an essential role in gap junction communication in the ventricles (By similarity).
What are the official names of this protein?
Gap junction alpha-1 protein, Connexin-43, Cx43, Gap junction 43 kDa heart protein.
What is the protein family that this protein belongs to?
Belongs to the connexin family. Alpha-type (group II) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65.
Protein: PFF1_NEOFI
Sequence: MARPSLSRSNPLGFTPWPVTVITAVVYLALVVPLLVVHHVVPSAPSSSPKGLNLTEAWTDLQVLTNGFHPYNSHRNDEVHEWLLKRILELINSAPPASEYESVDEAKPDIVVFDDTQSNLTFSGRASGLGVYFESTNIMVYIRGWEEDKERWWEDPHGRPAGKGGVLVNAHYDSVSTGYGATDDGVGVVSCLQLIKYFTTPGHVPRRGLVLLFNNGEEDFLNGARVYSQHPISQLPHTFLNLEGAGAGGRATLFRSSDAEVTKPYMRAPHPFGSVLSANGFEAGLISSQTDYVVFEGDLGLRGLDVAFMEPRARYHTDEDDARHTSLDSVWHMLSAAVATTEGLVSDASGRFEGLPREDGRIASGSGPRGVWFDLFGSAFVVFELHTLFALSVTLLVVAPLVLLVTSIALNRADKMYLFRASASPEDSDGSEAVLLHGVRGFFRFPFLLVIPTAVTVGLAYLVTKFNPYIIHSSEYAVWSMMISAWVFLAWFVSRVADFARPSAFHRVYTLTWLFLVEWVLLVISTVYENKYGLAGGYFVFFAFAGTFLATWISYLELFALPRKSEYATQLALPSRRASSHGSRLGTASGEDVEDGEDEDEDDDGTTAEATETTSLLRGQRTTFANYVRVTGDYLRDDGDEPRQPNLYGHEQAWSIHLPKWVWVLQFLLTAPLVLTFVGPLALLLTSALRQTGQDGSSSLFIYIAVAALTTLLFIPLLPFIHRYTHHIPLFLLCVFAGTLIYNLVAFPFSPANRLKLFFIQEVDLDTGVNHASLSGAYPFVHDVASSLPSTAGQNITCDLDLLRPKCSWHGIPPQVVQPAEASKMKDWLSYNITRSDAEPKAQLSISGRNTRACKLVFDRPVLSFTVADSAYDPRFPHVSPDGTKEIRLWSREWGHTWTVDVEWAADTEETDEKGLRLSGRVVCLWSDGNTAGVIPALDEVRRYVPVWVGVSKLSDGLVEGSRRFEI
What is the function of this protein?
May be involved in vacuolar sorting and osmoregulation.
What are the official names of this protein?
Vacuolar membrane protease, FXNA-related family protease 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: BIOB_NITEC
Sequence: MESRTDLISEKQCGCTYSNPDLAVQQESSSRWLVADVESLLGLPFNDLIFQAQTVHRQYHDANGVQLSTLLSVKTGGCSEDCAYCPQAARYHTGVENQAILSREEVVMAATKAKESGATRFCMGAAWRGPKQRDIEHMTELISAVKDLGLETCATLGILKPGQAVQLKQAGLDYYNHNLDTSPEFYGEVITTREYQNRLDTLDEVRGANINVCCGGIVGMGESRTARAGLIAQLASLDPYPESVPINYLVQVEGTPLYGIPELDPFEFVRSIAAARITMPRAKVRLSAGRRQMSEAIQALCFLAGANSIFYGDKLLTTGNPDTEQDAALLEKLGLHAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: VF113_ASFP4
Sequence: MAYPELDAADFLQQLARRKEFKSLISPPVDQKELIRDLRAHFVQIGGPGCEKGGRAFFPCDPYASPFPSIKGLQLHNAQLFVQNFQNPNTPYSRLLLNWQTGTGKSIAAIAIARQFMNHYMNFIENAPWIFVVGFTRAIIQTEMLRRPELGFVSYKEVAELHRLLHIAKQSGSTTSVESRHLNGFVSTLKRRLTDRNRGGFFQFYGYKEFASKLFNITSKGEEKNFDVLSLFHRSDEAEDTLNENDISQFVQKISEAETNGLIRVNQKIMEQLRGGLLIADEIHNVYNIQERNNYGIALQYVLDAFPPHQAPRAVFMSATPVTGSVMEYVDLLNLLVPRHELPNGQPLQRQQLFDSSGHSVKWKKDALALVERLSTGRVSFLLDTNTNFYPERIFAGKMLSYKDEKLPYLHFIECPMSEYQLETLKQLGPDPKISSNAYSIYDMVFPNPKFSKQTEPKAYGLFNSTETPTALSMASTDWLLENGVQIIEPSRRAPFNVSGSFLSLQPPTHISGLAFYSGKYTQMMKDILSIIRQGRGKILIYHNRVRMSGVLILQEILQSNGILNEVSSPVGTTRCSICAAIRDDHTHSDHQFIPVRFTILHSEIEPAVRERSLALFNASSNLEGHQLRILIGSKVIVEGLNFQAVRYEMIMSLPLDIPRLIQVFGRVVRKNSHMELPPSERNVTIYLYVSTTPDGGPELAKYAQKLKEYILIQEGDKALRKHAIDGFTNQIKIDKPMLESLPLSPSITPANVGATVLNTFEAYGYGEQEVKTISNIIISLFMARPVWTYSELWKAVSTPKLIQGITIDNKLFSEDNFALALISLCYSKNQCKELWIQNRLCTIMHVPAKPEHLYVAAVLNHKKEPVLDIETYIRDFQPPTMHSIRITKYLEHSQTKEPFQVLYEKFQKDFQDEPMEQVLIHYPASFHYTMLEALIIDNLAGMGALVEVYKKFFIAFSKKDIQPFPDIFKIISHVPGDDNTLVGYATEDSVRLITSREDKTWHEIPLYMLNINVKRKENDIVIGYMESKGKALKFKIRPPIQVLKKNEITDIRMLNRGAVCETRGREEQQKIANQLGISLNLTKISAIKLCLLIRNNLLQKEMEARNQPNGMQDGIRWFYLFNDKMPSLVHTS
What is the function of this protein?
Putative initation factor.
What are the official names of this protein?
Early transcription factor large subunit homolog, ATP-dependent helicase VETFS homolog.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
What are the subcellular locations of this protein?
Virion. Note=Found in association with viral nucleoid.
Protein: TA2R_BOVIN
Sequence: MWPNASSLGPCFRPMNITLEERRLIASPWFAASFCLVGLASNLLALSVLMGARQGSSQSRSSFLTFLCGLVLTDFMGLLVTGAIVVTQHFVLFEWQAVDPGCSLCHFMGVIMVFFGLCPLLLGAAMASERFLGITRPFSRPATASQRRAWTTVGLVWASALALGLLPLLGVGHYTVQYPGSWCFLTLGTDPGDVAFGLLFALLGSISVGMSFLLNTISVATLCHVYHGQATAQQRPRDCEVEMMVQLMGIMVVASICWMPLLVFIAQTVLQSPPAMSPTGQLSRLTERQLLIYLRVATWNQILDPWVYILFRRAVIQRFYPRLSTRSRSLSLQPQLTRRSTIH
What is the function of this protein?
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation.  The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.  In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction.  Activates phospholipase C and adenylyl cyclase.
What are the official names of this protein?
Thromboxane A2 receptor, TXA2-R, Prostanoid TP receptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SURE_BORBR
Sequence: MRILVSNDDGYNAPGLEALVEALSGLGELTVVAPETNHSGASNSLTLNRPLTVRTASNGFIYVNGTPSDCVHVALTGLMDARPDLVVSGINNGANMGDDTLYSGTVAAASEGYLFGIPSIAFSLIEKGWQHIESAARAARQVVERQIAQPLAAPVLLNVNIPNRRYEDMKGYAVTRLGKRHPSEPVVRTTTPYGDTVYWIGPVGLAADATPGTDFHATAQGQVSVTPLRLDLTQHSQLDDVRNWAEPLCVNA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_PSEPW
Sequence: MGAIPLEHGLAVAGILFCLGLVGLMVRRNILFVLMSLEVMMNASALAFIVAGARWVQPDGQVMFILVISLAAAEASIGLAILLQLYRRFHTLDIDAASEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PANC_JANMA
Sequence: MKIISCIEELRDHLRGQLRTAFVPTMGNLHDGHLSLMRLARKHGDPVVASIFVNRLQFGPNEDFDKYPRTFQADVEKLEKEGVYILFAPTEKDLYPEPQEFRVRPPDDLGNTLEGEFRPGFFSGVTTVVLKLFSCVQPSVAVFGKKDYQQLMIVRNMSKQFALPTEIIAADTYRAEDGLALSSRNVYLSPAERAEAPALFQSLNSVANEVRSGHLDIFELERKAMADLSQRGWKPDYISIRKQSNLQPPSAGDMAQGEKLVVLAAAKLGVTRLIDNLEI
What is the function of this protein?
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
What are the official names of this protein?
Pantothenate synthetase, PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme.
What is the protein family that this protein belongs to?
Belongs to the pantothenate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDX23_PONAB
Sequence: MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARFRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVPSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA
What is the function of this protein?
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation.  Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
What are the official names of this protein?
Probable ATP-dependent RNA helicase DDX23, DEAD box protein 23.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorlyated POLR2A/RNA polymerase II and kinase SRPK2.
Protein: RS7_MYXXD
Sequence: MPRRRVVAKRKILPDPKFQDRLVTKFVNDLMRKGKKSIAEGVCYGAFALIEERAKEDPLKTFKKALDNVKPVLEVKSRRVGGATYQVPVEVRQDRRVALGMRWIITYSKARGEKTMQEKLAGEIMDAANNRGNAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RECA_TROW8
Sequence: MSSNDQINRTRALELALANIDRQYGKGAVMRMNDAQKAYIDVIPTGSIALDYALGVGGLPRGRIVEIYGPESSGKTTLTLHAIASVQRAGGIAAFIDAEHALDPEYAKKLGVDIDALLVSQPDSGEQALEISDMLIRSTAIDLIVIDSVAALVPRAELEGDMGDMHVGLQARLMSQALRKITSGLNQTGTTAIFINQLREKVGVFFGSPETTPGGRALKFYASVRLDIRRVETIKQGTEAVGNRTRVKVVKNKVAPPFKQAEFDVLYGVGISRESGLIDFAVDRGIIKKSGSWYVYGDDQLGQGKENARRFLLENKSVADEIENKIISLLGFRSNEFGDLPDHDAAVRTSPDTNSRKVSGTGAVHTTSGSPSAGKGTASGAVNNSRDSTGGDTPAGQGPLNLSVNRDVSTDTVSSKISDATHNQKPAGNGKSVKRKG
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB2_LACJO
Sequence: MITVLTAGFGAIWGAILRYGITNYGKKHWSEKFPYATLLINLTGAFLLGFIFSRKFSPFIYALIGTGVLGGYTTFSTLNVELLSHWRDRNYSVFTLYALLSYGGGLILVFLGYKVGTLI
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 2.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ISPH_PROM9
Sequence: MDTQAFRRSLHHSDRYNRRGFDSPTKRAQALEEAYQSDLISSIRDNGFTYNKGRLNIKLAKAFGFCWGVERAVAMAYETRRHYPNENIWITNEIIHNPSVNDHLRKMNVKFISAKNGIKDFSLVSNGDVVILPAFGATVQEMKLLHEKGCHIIDTTCPWVSKVWHTVEKHKKHVFTSIIHGKFKHEETLATSSFAGKYLVVLDLEEANYISEYILGRGNRNEFMNKFAKACSDGFDPDKDLDRVGVANQTTMLKSETEEIGKVFEKTMLKKFGPENLNSHFLAFNTICDATEERQDAMFSLVDEDLDILVVIGGFNSSNTTHLQEIAITKNITSFHIDTPERISVEENSILHKPLGLDLELKNNFLPSGNINVGITSGASTPDKVVADVIEKLTVIAS
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: FDHE_PSEAE
Sequence: MSRTILQPGQIEAAANIPPHLHQPSRDLFARRGERLLQLAEGHPMGDYLRLVAGLCRLQQALLDNPPALAPLDPERLRKSREHGMPPLAYDLLVREGAWLPWLDALLAGYPAPANAAVGAALEQLREAEEGQRKAWAIALLSGQFDLLPAALVPFLGAALQVAWSHWLLGLEEGAVVETESRTLCPACGSPPMAGMIRQGGKETGLRYLSCSLCACEWHYVRIKCSHCEESKHLAYLSLEHDGQPAEKAVLRAETCPSCQGYLKQFYLEFDRHADALADDLASLALDMRLAEDGYLRRSPNLLLAPGGE
What is the function of this protein?
Necessary for formate dehydrogenase activity.
What are the official names of this protein?
Protein FdhE homolog.
What is the protein family that this protein belongs to?
Belongs to the FdhE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURG_HELPS
Sequence: MKFALTGGGTGGHLSIAKALAIELEKQGIEAIYLGSTYGQDKEWFENSPLFSERYFFNTQGVVNKSFFKKIGSLFLQAKAAFKAKEILKKHQITHTISVGGFSAGPASFASLLNKIPLYIHEQNAIKGSLNRYLSPKAKAVFSSYAFKDKGNHVLTSYPVQNAFFDFARTRTEIKHILFLGGSQGAKAINEFALLNAPKLTKQGIKITHICGSDAHERMRFFYQELGLLDKVELFAFHNNITEVMHRADLCVSRAGASSVWELCANGLPTIFIPYPFASNNHQYYNVLEFEKENLCYVVPQNELLPKKLFEVIRKLNQKDDQGNKNLTTISNQLQQKIAKDGAKTIIETILSA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CATAC_MOUSE
Sequence: MAPPQRCPLCRQTFFCGRGHVYSHKHQRQLKGALERLLPQVEAARRAVRAAQVERYVPEHDRCCWCPCCGCEVRKHLSHGNLTVLHGGLLEHLASPEHKKATNKFWWENKANAQMKEKFLISPQDYARFKKSMVKGLDSYEEKEDEVIKEMAAQIREVEQSRQEVVRSVLEPQAESDPEEGSSAPESWKATNGHVASSSQQVSHLALQPVAELDWMETGQQLTFIGHQDTPGIGNIHSGATPPWMIQEEEHSSGSLPIGPSYEEFLKEKEKQKLKKLPPDRVGANFDHSSNTSAGWLPSFGRVWNNGRRWQSRHQFKTEAATRSKQPRKGKS
What is the function of this protein?
Component of the minor spliceosome that promotes splicing of a specific, rare minor intron subtype.  Negative regulator of centrosome duplication.  Constrains centriole number by modulating the degradation of the centrosome-duplication-associated protein SASS6 in an acetylation-dependent manner.  SIRT1 deacetylates CENATAC in G1 phase, allowing for SASS6 accumulation on the centrosome and subsequent procentriole assembly.  The CENATAC acetylation level is restored in mitosis by NAT10, promoting SASS6 proteasome degradation by facilitating SASS6 binding to APC/C E3 ubiquitin-protein ligase complex/FZR1.
What are the official names of this protein?
Centrosomal AT-AC splicing factor, Coiled-coil domain-containing protein 84.