PharMolix/UniProtQA huggingface dataset:
Protein: PHNN_BURPS
Sequence: MSAERLVYVMGPSGAGKDSLLAYARKHVREPRIAFAHRYITRKSDGHENHVELTRDEFAARAQLGFFALEWSSHGFRYGVGVEIDAWLAAGSVVVVSGSRAHLPAALERYPQMCVVHIDAAPHVLAERLATRGRETADEIRARLARSVRWAVPDGVALTAIDNSGTLDDAGRVLVALLEGLARS
What is the function of this protein?
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
What are the official names of this protein?
Ribose 1,5-bisphosphate phosphokinase PhnN, Ribose 1,5-bisphosphokinase.
What is the protein family that this protein belongs to?
Belongs to the ribose 1,5-bisphosphokinase family.
Protein: MDLC_PSEAE
Sequence: MKTVHSASYEILRRHGLTTVFGNPGSNELPFLKDFPEDFRYILGLHEGAVVGMADGFALASGRPAFVNLHAAAGTGNGMGALTNAWYSHSPLVITAGQQVRSMIGVEAMLANVDAGQLPKPLVKWSHEPACAQDVPRALSQAIQTASLPPRAPVYLSIPYDDWAQPAPAGVEHLAARQVSGAALPAPALLAELGERLSRSRNPVLVLGPDVDGANANGLAVELAEKLRMPAWVAPSASRCPFPTRHACFRGVLPAAIAGISRLLDGHDLILVVGAPVFRYHQFAPGDYLPAGAELVQVTCDPGEAARAPMGDALVGDIALTLEALLEQVRPSARPLPEALPRPPALAEEGGPLRPETVFDVIDALAPRDAIFVKESTSTVTAFWQRVEMREPGSYFFPAAGGLGFGLPAAVGAQLAQPRRQVIGIIGDGSANYGITALWSAAQYRVPAVFIILKNGTYGALRWFAGVLEVPDAPGLDVPGLDFCAIARGYGVEALHAATREELEGALKHALAADRPVLIEVPTQTIEP
What are the official names of this protein?
Benzoylformate decarboxylase, BFD, BFDC.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family.
Protein: IF5A_MANES
Sequence: MSDEEHHFESKADAGASKTFPQQAGTIRKNGYIVIKNRPCKVMEVSTSKTGKHGHAKCHFVGIDIFNGKKLEDIVPSSHNCDVPHVNRTDYQLIDISEDGFVSLLTETGNTKDDLRLPTDENLLSQIKDGFAEGKDLVVSVMSAMGEERICSLKDIGPKN
What is the function of this protein?
The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Eukaryotic translation initiation factor 5A, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
Protein: RL18_LISMO
Sequence: MITKIDKNKVRKKRHARVRSKISGTESRPRLNVFRSNKNIYAQIIDDVNGVTLASASNLDKDFGSAESKVDAASKVGELVAKRASEKGITSVTFDRGGYLYHGRVKALAEAARENGLEF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: TO6BL_HUMAN
Sequence: MEGTAVAVFEILRFLIIHWKCDIDVSKGALLEGQLVISIEGLNSKHQANALHCVTTVASAGSLFGGMVLKKFLKEIQSILPGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEPTLNLGNGIALLVDSQHYVRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSVSIFLYGPLGLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDAPDNSSLELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPEATAAPLTPRGREHREAHGRALAPGRASLGSRLEDVLWLQEVSNLSEWLSPSPGP
What is the function of this protein?
Component of a topoisomerase 6 complex specifically required for meiotic recombination.  Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.  The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles.
What are the official names of this protein?
Type 2 DNA topoisomerase 6 subunit B-like, Type 2 DNA topoisomerase VI subunit B-like, TOPOVIBL.
What is the protein family that this protein belongs to?
Belongs to the TOP6B-like family.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes to meiotic chromosomes.
Protein: HFQ_BAUCH
Sequence: MAQGQSLQDIFLNVLRRERIQVSIYLFNGIKLQGHIESFDQFVIVLKNTISQMVYKHAVSTIVPSKFVSHYANNSSNYSNHSGDRN
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: KASH5_HUMAN
Sequence: MDLPEGPVGGPTAEMYLRERPEEARLGMPVSLEEQILNSTFEACDPQRTGTVAVAQVLAYLEAVTGQGPQDARLQTLANSLDPNGEGPKATVDLDTFLVVMRDWIAACQLHGGLELEEETAFQGALTSRQLPSGCPEAEEPANLESFGGEDPRPELQATADLLSSLEDLELSNRRLVGENAKLQRSMETAEEGSARLGEEILALRKQLHSTQQALQFAKAMDEELEDLKTLARSLEEQNRSLLAQARQAEKEQQHLVAEMETLQEENGKLLAERDGVKKRSQELAMEKDTLKRQLFECEHLICQRDTILSERTRDVESLAQTLEEYRVTTQELRLEISRLEEQLSQTYEGPDELPEGAQLRRVGWTELLPPSLGLEIEAIRQKQEVATADLSNPLCGVWQWEEVIHETSEETEFPSEAPAGGQRNFQGEPAHPEEGRKEPSMWLTRREEEEDAESQVTADLPVPLGAPRPGDIPENPPERPARRELQQALVPVMKKLVPVRRRAWGQLCLPPQRLRVTRHPLIPAPVLGLLLLLLLSVLLLGPSPPPTWPHLQLCYLQPPPV
What is the function of this protein?
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton.  The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.  Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly.  Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes.  Essential for male and female gametogenesis.  Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes.  In oocytes is involved in meiotic resumption and spindle formation.
What are the official names of this protein?
Protein KASH5, Coiled-coil domain-containing protein 155, KASH domain-containing protein 5.
What are the subcellular locations of this protein?
Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus. Chromosome, telomere. Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles.
Protein: SHA9A_DANRE
Sequence: MKWTVLLLEYFLVKVLVLLYSADGEAQQLEGFIMLSGSNGSRDEESVSEPPHTEDKCRGYYDVMGQWDPPFVCQTGNYLYCCGTCGFRFCCAYKNSRLDQSTCKNYDTPVWLTGQTPYKKTLDPRHDPTKDKTNLIVYIICGVVAIMALVGIFTKLGLEKAHRPHRESMSRAVASVMQGARQGQHEEAIGMHTQHYDTVQARANNMQAGQINNMMQTHPYPALSQLSHVYEQQQSAKDLNKYASLKAVAAKANGDFLNKQHRHLVELAAKGNLPLHPIRMEHVEPTATYVTEVPCIKQNGQKPKSIKANVSHPAMAYSSNTIANPGMLRSWEAAETAGRRKTYNPRKMCMVEQVNELHTARSHHYLPTQPYFVTNSKAEVTV
What is the function of this protein?
Regulator of short-term neuronal synaptic plasticity in the dentate gyrus.  Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity).
What are the official names of this protein?
Protein shisa-9A.
What is the protein family that this protein belongs to?
Belongs to the shisa family. SHISA9 subfamily.
What are the subcellular locations of this protein?
Cell projection, dendritic spine membrane; Single-pass type I membrane protein. Synapse.
Protein: FADB_PECAS
Sequence: MLYQGESLYLNWLEDGIAELVFSAPGSVNTLDTRTVASLGKALDVLAEQPNLKGLLLRSDKPAFIVGADITEFLSLFAAPAEKLHEWLVFANSIFNRLEDLPVPTLSAINSYALGGGCECVLATDFRLATPDARIGLPETKLGIMPGFGGTVRLPRLLGADSALEIIAAGKDVSAADALKVGLVQAVVANEKLIPAAIKMLKQAINGELDWLGYRRPKLEALKLNKIEAMMSFTTAKAMVLQTAGKHYPAPMLAVKTIEAAATMTRDEALQLETQHFVQLARSNEARALVGIFLNDQYVKGKAKKLVGETPVPQQAAVLGAGIMGGGIAYQSAFKGVPIRMKDINEKPLALGMNEAAKLLNKQMERGKLDGMKMATILANIHPTLDYAGFERTDIVVEAVVENPKIKASVLAETESHISESTILASNTSTIPIAVLAAALKRPQNFCGMHFFNPVHRMPLVEIIRGPKTSDSTIASVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAAFSLLLRDGADFREIDNAMEKKFGWPMGPAYLLDVVGIDTAHHAQAVMAEGFPQRMAKDYRDAIDVLFEHQRFGQKNGQGFYRYQTDSKGKQRKEQDDAVDALLKNISQPKKAFSAEEIIARMMIPMINEVARCLEEGIVASPAEADMALVYGLGFPPFHGGACRYLDTLGSERYVEMAQQLAHLGAIYQVPDGLQQKARSNEGYYPSVAPHADVSHGQPA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: RL20_ACIC5
Sequence: MPRVKRGTKRSDRRKKILKRASGYFLTKSKLYQAAQEAVERGLKFAYSGRKQKKRQFRSLWIVRIGAAAKLNGMSYSQFVHGLKVAGIELDRKVLSDIATNDAAGFTALAEQAKAALANQPAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: SYGA_NOSS1
Sequence: MNFQSVIATLHQFWAERGCLIAQPYDIEKGAGTKNPHTFLRALGPEPWAVAYIEPCRRPTDGRYGENPNRFQHYYQYQVLIKPSPDNIQDIYLDSLRALGIRPEDHDIRFVEDNWEDATVGAWGTGWEVWLDGMEITQFTYFQQCGGIDCRPVSIEITYGLERLAMYLQEVEAITKIHWTDDITYGDVFLQNEIEQSTYNFEASNPELLLTLFNLYEQEASQLTERGLVLPSLDYVMKCSHTFNLLDARGVISVTERTRYIARIRHLARKVANLYVEQREKLGFPLLKNVPVAR
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTH_XANCB
Sequence: MSASVVLQPGQVTLAQWRALYRGAEVTLDPACAQAVLRSAQTVEAIVARGEPVYGVNTGFGKLASVRIERDDLQTLQRNIVLSHAAGVGDPTPVPVVRLMMALKLTSLAQGASGIQPDTLALLEAMLRQGITPVVPCQGSVGASGDLAPLSHLAAVMIGVGEAFVGDQRLPAADALARAQLQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDARIHALRGQPGQIATAAALRALMAESAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQAARTLEIEANGVSDNPLVFSDTGEALSGGNFHAEPVAFAADMLALAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQCAYPASVDSIPTSANQEDHVSMAAHGARRLLAMADNAAHVIGIELLAAVQGCDFHAPLRSSAALEAARALLRAQVPTLQDDRYFHPDMLAASALVRSGALATAVGIVLPGVELSA
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK20_ADICA
Sequence: MTRVKRGSVARKYRKNILDFVSGFRGAHSKLFRTANQRRGRSLAYAYVDKNNSKRAFRRLWIARINAAARRDGITYSSVIHSLYKNRIALNRKTLAQIATLDAYCFSMIIEKVSKIKI
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: OXDD_HUMAN
Sequence: MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
What is the function of this protein?
Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.
What are the official names of this protein?
D-aspartate oxidase, DASOX, DDO.
What is the protein family that this protein belongs to?
Belongs to the DAMOX/DASOX family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: BMP4_RAT
Sequence: MIPGNRMLMVVLLCQVLLGGATDASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQSQGTGLEYPERPASRANTVRSFHHEEHLENIPGTSESSAFRFFFNLSSIPENEVISSAELRLFREQVDQGPDWEQGFHRINIYEVMKPPAEMVPGHLITRLLDTRLVRHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHTLTRRRAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
What is the function of this protein?
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity).  Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).  Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2.  Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A.  In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.  Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades.  For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity).
What are the official names of this protein?
Bone morphogenetic protein 4, BMP-4, Bone morphogenetic protein 2B, BMP-2B.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: MFS_MENPI
Sequence: MAALLVFFSVSLILLAVLFHKRKSSLSSRKRPPPSPLRLPVIGHFHLIGALSHRSFTSLSKRYGEVMLLHFGSAPVLVASSAAAAREIMKNQDVIFASRPRLSIFDRLMYSGKGVAFAPYGEHWRNARSMCMLQLLSAKRVQSFGGIREEETSAMIEKIRRSKPTTVVNLSEMFMALTNGVIHRAVLGRKGDGGDDFNRILIKVIKLLGSFNVGDYVPWLSWINRINGVDAEVEKVGTKLDGSMEGILRKYRRKKVGDDETNFVDTLLQFQRESKDTDPVEDDVIKALIFDMVSAGTDTTFAALEWTMAELIKNPRTLKTLQNEVREVSRNKGGITEDDVDKMPYLKAVSKEILRLHPPFAILLPRELTQDANMLGYDIPRGTVVLVNNWAISRDPSLWENPEEFRPERFLETSIDYKGLHFEMLPFGSGRRGCPGSTFAMALYELALSKLVNEFDFRLGNGDRAEDLDMTEAPGFVVHKKSPLLVLATPRQS
What is the function of this protein?
Monoterpene synthase that catalyzes the formation of (+)-menthofuran from (+)-pulegone.
What are the official names of this protein?
(+)-menthofuran synthase, (+)-pulegone 9-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: ERPA1_METCA
Sequence: MTSIVDLTPSEPALIFTGNAAAKVSELIAEEGNPALKLRVYVSGGGCSGMQYGFAFEEAVNEDDTTVEKDGVVLLVDPTSLQYLQGAEIDYQEGLEGSRFVIKNPNATSSCSCGSSFSVDGGASCSSH
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA 1.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: SYH_COXBN
Sequence: MTKSIQAIRGMSDTLPEEIPYWSFLENACRSVVSAYHYREIRFPVVEQTALFKRTIGEATDIVEKEMYTFTDRNGDSLTLRPEGTAGCVRAGIQNGLFYNQIQRLWYLGPMFRHERPQKGRYRQFYQLGVETYGMAGAPIEAELIFMCLRLWKALGLESCIHLELNTLGTLDSRNAYRQALVTYLQSREKELDEDSRRRLHTNPLRILDSKNPDLQPLLAEAPKLIDYLDETSRRHFDQLRSLLDQAEVPFIVNPTLVRGLDYYTHTVFEWVTDQLGAQGTVCAGGRYDNLVELLGGKSTPAAGFAAGLERLVLLLRGVQECLDKIDIYVVIAGEAVIQEGLLMTEQLRNVLPEWVIEADLSGSSLKSQFKRADKSGAKWALVIGEEEIKTNTVTLKHLRETVPQKSLTRDTLIPYLKSEG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACKA_ACTPJ
Sequence: MSKNLILILNCGSSSLKFAVLDPKTGDEKLSGLAEAFNLEDARIKWKLHGEKGNADLGAGAAHSEALTFIANELLSEELKSSIGAIGHRIVHGGEQFTSSVVINDDVVKGIEHAIQFAPLHNPAHLIGIKEAFRIFPELKEKNVAVFDTAFHQTMPEEAFLYALPYKLYKEHGIRRYGAHGTSHLFITSQVAELAGKPVDQTNAIICHLGNGGSVSVVRNGKCIDTSMGLTPLEGLVMGTRSGDIDPAIVFYLYKNLGMSMEQIEDTLVKKSGLLGLTEVTSDCRYAEDNYEDASKPEAKRALDVYSYRLAKYIGAYMAILGDDHLDAIAFTGGIGENSGHVRELALNHLKLFGVKLDVERNLAARFGKSGVITADDSTFKAVVIPTNEELVIAQDTAKLAL
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_DAMPP
Sequence: MAYPMQLGLQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILIMIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSDLKPGELRLLEVDNRVVLPMEMTVRMLISSEDVLHSWAVPSLGLKTDAVPGRLNQTTLMSTRPGLYYGQCSEICGSNHSFMPIVLELVPLKHFEKWSASML
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL28_HALH5
Sequence: MARKCYITGRQAKSGNKRSHAMNKTKRRWGANVQKVRILVDGKPKRVYVSARALKSGKVERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: TRMD_PAEAT
Sequence: MRIDVVSIFPEYLAPLELSLIGKARQDGLLELNVHDLRTFTTDKHRTVDDTPYGGGAGMVMKPEPWAQALESVAAARENSKPVLIVPSPAGEKFNQALAYELAEEEQLVFACGRYEGIDERVIDWAQDHFRVRPVSLGDYVLNGGEVAVLAMVEAIGRLLPGVVGNPESLVEESHSDGLLEYPVYTKPSAWRDHDVPPILLSGNHGKIAQWRRHEQFRRTAERRPDLMEGLDAGVLSRADRQALADLGYDVVDGRLRAKPGGDTEN
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAB_ALTMD
Sequence: MQTSMIAAIYKNFLGHAPDWYKKTIIAFLIVNPFIFMVDPYIAGWTLVIQFIFTLAMALKCYPLQPGGLLLIEAMFIGMTSPGHMMHEIEVNLEVLLLLVFMVAGIYFMKDLLMFLFTKLVIKVRNKLILSLSFIFASAFLSAFLDALTVVAVIISVGLGFYSIYHKVASGKEFHSDHDHTSDDELGSHDLEDFRAFLRNLMMHSAVGTALGGVMTMVGEPQNLIIADKAGWDFVEFFIRMAPVTLPVFVFGLLTTVVLEKTGTFSYGAKLPSAVRQILVDYNDHMDKGRSKRETAKLVVQALIGIWLIVGLATHMASVGLIGLSVIVLATSMSGVIEEHALGKAFEEALPFTALLCVFFGVVAVIIDQGLFQPVIHWVLSFEGETQMVMFYLANGVLSMVSDNVFVGSVYITEVTAALEAGQITRDQYDMLAVAINTGTNLPSVATPNGQAAFLFLLTSAIAPLLRLSYGRMVMMALPYTIVLTIVGLVATYIGLADATQVLYDMHLIEHHTAVEAGAQAVGH
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MLE1_CHERA
Sequence: MPKAPAKKAEPAPAPAPAPEPAPAPAAPAVDLSAVKVEFSADQIEDYREAFGLFDRVGDNKVAYNQIADIMRALGQNPTNKEVSKLLGNPSADDMTNKRVEFEAFLPMLQTIINSPNKAGFEDYVEGLRVFDKEGNGTVMGAELRIVLSTLGEKMTEAEIDALMAGQEDENGVVNYEAFVKHIMSV
What are the official names of this protein?
Myosin light chain 1, skeletal muscle isoform, LC-1, LC1, Myosin light chain alkali 1, Myosin light chain A1.
Protein: GLYA_MACCJ
Sequence: MSEIKQQDNQVFEAITKEFERQDHHIELIASENFVSKAVMEAQGSVLTNKYAEGYPHRRYYGGCEFVDIVEDLARDRIKELFGAEHVNVQPHSGSQANMAVYRVALKPGDTVLGMNLSHGGHLTHGSSVNFSGVDYNFVAYGVDKETEKIDYDVVRELAREHKPALIIAGASAYSRIIDFEEFKAIADEVGAKLMVDMAHIAGLVAAGLHPNPVPHADFVTTTTHKTLRGPRGGMIICKEEYAKAIDKMIFPGIQGGPLMHVIAAKAVAFGEALTADFKAYQQQVVLNAKTLADALTEKGLRIVSGGTDNHVMSIDVTSFNITGKVAERALDDVGITTNKNTIPFDKESPFVTSGIRIGTPAVTTRGFNEEDMKEIASIIADVLAHPEDENVKHDAKVRVRAITEKYPLYK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_MARSD
Sequence: MPYVPHSPEEIREMLDVIGVNSVEDLFAEIPAELRPKSFNLPKGKSEMAVLQQLDKMAAKNTTDLTSFLGAGFYDHFIPTAVDALSSRSEFYTAYTPYQPESSQGTLQAIFEYQTAMARLMDMDYANASVYDGGSALYEATLMAVRKTRRRKIIVSEALNPIYRVMLDSYTTNLNLELVTVPHNHGRTNVKSITAAVDKDTAAVIVQNPNFFGSVNDFTEMFAAVHEHKALAIMSTYPVMQSVLKTPGQMGADIAVADGQSIGQPLSFGGPYLGIMTCSKALVRQMPGRIAGRTEDEDGKTGYVLTIQAREQHIRRQKATSNICSNQALCALRTLIHLCLLGEEGLNRTAVLSVERAHYAAERLTAIDGVEMFTKGPFGNEFAVTLPVNAFEVIDKLTERGIIPGFPVGRYYEGLENVLLVACTEKTTEEQIGIFAEILRGTI
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: MSCL_BRAHW
Sequence: MIKEFKKFIMKGSILDMAVGLVIGAAFTKIVNSFVDDILMPPIGMILSGIDFSNIFIVIKKGTDTLGNYNSIEAARNAGAVVIGIGVFINAIISFIITALSLFIIIKLFNKIQEKTVKKEKDEKESKEKVCPYCYSSININAVKCPNCTSDLDVK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RIMP_MANSM
Sequence: MATLEQNLQQMLQGSVEDLGCELWGIECQRAGRFMTVRLYIDKEGGVTVDDCADVSRQVSAILDVEDPIADKYNLEVSSPGLDRPLFTLEQFQRYVGQEISVHLRIPMLDRRKWQGKLERIEGDMLTLIVDDQEQSFALSNIQKANVIPKF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.