PharMolix/UniProtQA huggingface dataset:
Protein: GCST_CUPMC
Sequence: MTLQATPLNAIHRALGARMVDFGGWDMPVNYGSQIEEHNAVRADAGMFDVSHMCVVDLSGIHARAFLRGLLANNIDKLQTPGKALYSCMLDEKGGVIDDLIVYFFAEDRFRLVVNASTAVGDIEWIQSRNTATGSGVTITPRRGDLAPACVSKLAIVAVQGPNARQKVYDAFPSTQPADTLKPFNAVVVHDAEMGELMVARTGYTGEDGFELVVPAENVAGIWEKLSASGVRPAGLGARDTLRLEAGMNLYGQDMDIHTSPLDAGLSWTVDLQSERDFIGKSALLASGQQKTFAGLILRDKGGVLRAHQKVITPAGDGEITSGTFSPSLSQSIAFARLPRDIAPGTEVQVEIRDRKLTATVVKLPFVRNGKALVS
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: TRMD_BACTN
Sequence: MRIDIITVLPEMIEGFFNCSIMKRAQNKGLAEIHIHNLRDYTEDKYRRVDDYPFGGFAGMVMKIEPIERCINALKAERDYDEVIFTTPDGEQFNQPMANSLSLAQNLIILCGHFKGIDYRIREHLITKEISIGDYVLTGGELAAAVMADAIVRIIPGVISDEQSALSDSFQDNLLAAPVYTRPADYKGWKVPDILLSGHEAKIKEWELQQSLERTKKLRPDLLED
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RMD3_MOUSE
Sequence: MSRLGALGGSRAGLGLLLGTAAGLGFLCVLYSQRWKRTQRHGRSHSLPNSLDYAQASERGRQVTQFRAIPGEAGDAAILPSLSQEGQEKVLDRLDFVLTSLMALRREVEELQRSLQGLAGEIVGEVRSHIEENQRVARRRRFPFARERSDSTGSSSVYFTASSGAALTDAESEGGYTTANAESDYERDSDKESGDAEDEVSCETVRMGRKDSLDLDVEAASSPAAAALEEDDSSGREDVQLVLLQADELHQGSKQDKREGFQLLLNNKLAYGSRQDFLWRLARAYSDMSDLTEEESGKKSYALNGKEEAEAALKKGDESAACHLWYAVLCGQLAEHEGISKRIQSGFSFKEHVDKAIELQPEDPRGHFLLGRWCYQVSHLNWLEKKTATALFESPLSATVQDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARKWMKLAQELPDVTNEDSAFQKDLEELEVILG
What is the function of this protein?
Involved in cellular calcium homeostasis regulation (By similarity).  May participate in differentiation and apoptosis of keratinocytes.  Overexpression induces apoptosis (By similarity).
What are the official names of this protein?
Regulator of microtubule dynamics protein 3, RMD-3, mRMD-3, Protein FAM82A2, Protein FAM82C.
What is the protein family that this protein belongs to?
Belongs to the RMDN family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.
Protein: FACR3_ARATH
Sequence: MSTEMEVVSVLKYLDNKSILVVGAAGFLANIFVEKILRVAPNVKKLYLLLRASKGKSATQRFNDEILKKDLFKVLKEKYGPNLNQLTSEKITIVDGDICLEDLGLQDFDLAHEMIHQVDAIVNLAATTKFDERYDVALGINTLGALNVLNFAKRCAKVKILVHVSTAYVCGEKSGLIMETPYRMGETLNGTTGLDINYEKKLVQEKLDQLRVIGAAPETITETMKDLGLRRAKMYGWPNTYVFTKAMGEMMVGTKRENLSLVLLRPSIITSTFKEPFPGWTEGIRTIDSLAVGYGKGKLTCFLCDLDAVSDVMPADMVVNSILVSMAAQAGKQEEIIYHVGSSLRNPMKNSKFPELAYRYFSIKPWTNKEGKVVKVGAIEILSSMRSFHRYMTIRYLIALKGLELVNIILCKLFEKEFQYFNKKINFIFRLVDLYQPYLFFYGIFDDSNTEKLRKMVSKTGVENEMFYFDPKVLDWDDYFLNTHVIGLLKYVF
What is the function of this protein?
Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.  The preferred substrates are C24:0 and C26:0.  May be unable to use saturated and monounsaturated C16 and C18 acyl-CoA as substrates.  Involved in cuticular wax formation.
What are the official names of this protein?
Fatty acyl-CoA reductase 3, Protein ECERIFERUM 4.
What is the protein family that this protein belongs to?
Belongs to the fatty acyl-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: BMP2A_XENLA
Sequence: MVAGIHSLLLLLFYQVLLSGCTGLIPEEGKRKYTESGRSSPQQSQRVLNQFELRLLSMFGLKRRPTPGKNVVIPPYMLDLYHLHLAQLAADEGTSAMDFQMERAASRANTVRSFHHEESMEEIPESREKTIQRFFFNLSSIPNEELVTSAELRIFREQVQEPFESDSSKLHRINIYDIVKPAAAASRGPVVRLLDTRLVHHNESKWESFDVTPAIARWIAHKQPNHGFVVEVNHLDNDKNVPKKHVRISRSLTPDKDNWPQIRPLLVTFSHDGKGHALHKRQKRQARHKQRKRLKSSCRRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNTNIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
What is the function of this protein?
Induces cartilage and bone formation.
What are the official names of this protein?
Bone morphogenetic protein 2-A, BMP-2-I.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: MATK_WHEAT
Sequence: MEKFEGYSEKHKSRQQYFVYPLLFQEYIYAFAPDYGLNGSEPVEIVGCNNKKFSSLLVKRLIIRMYQQNFLDNSVNHPNQDRLLDYKNYFYSEFYSQILSEGFAIVVEIPFSLRELFCPKEKEIPKFQNLRSIHSIFPFFEDKFLHLDYLSHIEIPYPIHLEILVQLLQYRIQDVPSLHLLRFLLNYYSNWNSFITSMKSIFIFKKENKRLFRFLYNSYVSEYEFFLLFLRKQSSCLPLASSGTFLERIHFSRKMEHFGIMYPGFSRKTLWFFMDPLMHYVRYQGKAILASKGTFLLKKKWKCYLINLWQYYFCFWTQPRRIHINQLANSCFDFMGYLSSVPKSSLLVRNQMLENSFLIDTRMKKFDTIVHATLLIGYLSKAQFCTGSGHPISKPIWTDLSDWDILDRFGRICRNLFHYYSGSSKKKTLYRLKYILRLSCARTLGPKHKSTVRAFMQWLGSVFLEEFFREEEQVFSLMFAKTTYFSFRGSHSERIWYLDILRINDLVNPLN
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NCPP_METJA
Sequence: MARHKLRIVAVGSTNPVKIEAVKEGFEKVLGAVEVIGVDVISGVSSHPIGLEETYLGALNRAKNAFEKVQCTYAVGIEAGLIKVGEHYIDIHICVVFDGVNETVGLSQGFEYPKIVAEKVLEGIEGGKIAEEISGIKDIGKNIGLIGYLTDNNITRKDLCRESVIMALIPRMIKNAHLY
What is the function of this protein?
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives.  Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
What are the official names of this protein?
Probable inosine/xanthosine triphosphatase, ITPase/XTPase, Non-canonical purine NTP phosphatase, Non-standard purine NTP phosphatase, Nucleoside-triphosphate phosphatase, NTPase.
What is the protein family that this protein belongs to?
Belongs to the YjjX NTPase family.
Protein: MDH_FLAJ1
Sequence: MKVTIVGAGNVGATCADVISYRGIASEVVLLDIKEGFAEGKALDITQCATNTGFNTKVSGVTNDYSKTAGSDVVVITSGIPRKPGMTREELIGINAGIVKTVAENVLKYSPNTIIVVVSNPMDTMTYLALKATGLPKNRIIGMGGALDSSRFRTYLSLALDKPANDISAMVIGGHGDTTMIPLTRLASYNGIPVSQFLSEDVLQKVAADTMVGGATLTGLLGTSAWYAPGASVAYLVDSILNDQKKMIACSVFVEGEYGQNDICIGVPCIIGKNGVEEIVNINLNDQEKALFAKSADAVRGMNDALKSILV
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 3 family.
Protein: RS14_GLUDA
Sequence: MAKISAVNRNAKRARMAGRDKAKRIALKNIIMDRTLPVEDRFEASMKLAELPRNGSRVRVRLRCKLTGRARANYRKFELCRVALRDLASSGQIPGMVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: 104L_IIV6
Sequence: MPHYVVVKSPMRRRRSPRRRSPRVCYSPRRVACSPRRRSPRRRSPRRRSPRRSIVVY
What are the official names of this protein?
Uncharacterized protein 104L.
Protein: SGCG_MOUSE
Sequence: MVREQYTTVTEGTHIERPENQHIYKIGIYGWRKRCLYLFVLLLLAILVVNLALTIWILKVMWFSPIGMGHLHVTADGLRLEGESEFLFPLYAKEIRSRVDSSLLLQSTQNVTVSARNSEGEVTGRVKVGAQMVEVQSQHFQINSEDGKPLFSAEEQDVVVGTGRLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHVKANAGKLEALSQMDIILQSSEGVLVLDAETVGLTKLKQGTQGPAGSSNGFYEICACPDGKLYLSMAGEVTTCEEHSHVCL
What is the function of this protein?
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
What are the official names of this protein?
Gamma-sarcoglycan, Gamma-SG, 35 kDa dystrophin-associated glycoprotein, 35DAG.
What is the protein family that this protein belongs to?
Belongs to the sarcoglycan beta/delta/gamma/zeta family.
What are the subcellular locations of this protein?
Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
Protein: CAIB_SHIDS
Sequence: MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKARETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMSKGKDPYYAGCGLYKCADGYIVMELVGITQIEECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLAAHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKRPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
What is the function of this protein?
Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine.  Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
What are the official names of this protein?
L-carnitine CoA-transferase, Crotonobetainyl-CoA:carnitine CoA-transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. CaiB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_SHEB5
Sequence: MKQLRLEPVVQVRGEINIPGSKSISNRALLLATLAQGTTTLTNLLDSDDIRHMLASLKQLGVNYRLSQNNTVCELDGLGGVISSESAQELFLGNAGTAMRPLCAALTLGQGEFTLTGEPRMEERPIGDLVDALRQLGANVVYLKNDGFPPLTINATGLSGGDVEIAGDLSSQFLTALLMVAPLAKGSVNIHVKGELVSKPYIDITLALMAQFGVTVINHDYARFEIVAGQRYVSPGKVLVEGDASSASYFLAAGAIKGGEVKVTGVGRLSIQGDVKFADVLEKMGADIEWGDDYIIARGSQLTAVDLDMNHIPDAAMTIATAALFAKGTTVIRNIYNWRIKETDRLAAMATELRKVGAEVEEGNDYIKITPPAVINTAEIDTYNDHRMAMCFSMLAFADCGITINDPDCTSKTFPDYFKQFASLQG
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBL_CORGT
Sequence: MRFPELEELKNRRTLKWTRFPEDVLPLWVAESDFGTCPQLKEAMADAVEREVFGYPPDATGLNDALTGFYERRYGFGPNPESVFAIPDVVRGLKLAIEHFTKPGSAIIVPLPAYPPFIELPKVTGRQAIYIDAHEYDLKEIEKAFADGAGSLLFCNPHNPLGTVFSEEYIRELTDIAAKYDARIIVDEIHAPLVYEGTHVVAAGVSENAANTCITITATSKAWNTAGLKCAQIFFSNEADVKAWKNLSDITRDGVSILGLIAAETVYNEGEEFLDESIQILKDNRDFAAAELEKLGVKVYAPDSTYLMWLDFAGTKIEEAPSKILREEGKVMLNDGAAFGGFTTCARLNFACSRETLEEGLRRIASVL
What is the function of this protein?
Catalyzes the transformation of cystathionine to homocysteine.
What are the official names of this protein?
Cystathionine beta-lyase, CBL, Beta-cystathionase, Cysteine lyase, Cysteine-S-conjugate beta-lyase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily.
Protein: DHSS_SYNP1
Sequence: MQDKAMLMIPGPTPVPESVLLSLGKHPIGHRSGEFSQIMAAMTAGIKWLHQTQNEVLILAASGTGAMEAGIINFLSAGDRVVVGCNGKFGDRWGEVCDAYGLTTERISAPWGQPLNPDDFKAVLDGHRQKPSKAVIVTHSETSTGVINDLEAINRHVKAHGQALIIVDAVTSLGAVSVPIDEWGLDVVGSGSQKGYMIPPGLAFVSVSPKAWEAYKTATLPKFYLDLGKYRKDAAKHTTPFTPPVNLFFALKTALEMMQAEGLEAIFQRHQRLMQATRAAMKALNLPLYAADSCASPAITAVAPQGVEAENIRSLMKKRFDIALAGGQDHLKGQIFRIGHLGFVGDRDILAAVSALEAVLAELGYTNFTPGAGVAAASRVLSTA
What is the function of this protein?
Soluble hydrogenase catalyzes both production and consumption of hydrogen from suitable artificial electron donors or acceptors.  This subunit catalyzes the tritium-exchange activity.
What are the official names of this protein?
Soluble hydrogenase, small subunit, Tritium exchange subunit.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNP1_ARATH
Sequence: MDSDQGKLFVGGISWETDEDKLREHFTNYGEVSQAIVMRDKLTGRPRGFGFVIFSDPSVLDRVLQEKHSIDTREVDVKRAMSREEQQVSGRTGNLNTSRSSGGDAYNKTKKIFVGGLPPTLTDEEFRQYFEVYGPVTDVAIMYDQATNRPRGFGFVSFDSEDAVDSVLHKTFHDLSGKQVEVKRALPKDANPGGGGRSMGGGGSGGYQGYGGNESSYDGRMDSNRFLQHQSVGNGLPSYGSSGYGAGYGNGSNGAGYGAYGGYTGSAGGYGAGATAGYGATNIPGAGYGSSTGVAPRNSWDTPASSGYGNPGYGSGAAHSGYGVPGAAPPTQSPSGYSNQGYGYGGYSGSDSGYGNQAAYGVVGGRPSGGGSNNPGSGGYMGGGYGDGSWRSDPSQGYGGGYNDGQGRQGQ
What is the function of this protein?
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.
What are the official names of this protein?
Heterogeneous nuclear ribonucleoprotein 1, hnRNP1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. Relocalization from the cytoplasm into the nucleus is mediated by TRN1 (By similarity).
Protein: RS9_PYRAE
Sequence: MPSAEVLQETPRVVISVGKKKTAVARAIIKPGIGRVRINGYPLELWPIEMARIKMSEPLILAGELAKKVDIDVNVSGGGYMGQAVAVRIAMARGLVAFFQSQELKELYERYDPYMLKGDPRRTEHKKPGIKHARSKRQKAYR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: BTRN_NIACI
Sequence: MDKLFSMIEVEVNSQCNRTCWYCPNSVSKRKETGEMDPALYKTLMEQLSSLDFAGRISFHFYGEPLLCKNLDLFVGMTTEYIPRARPIIYTNGDFLTEKRLQTLTELGIQKFIVTQHAGAKHKFRGVYDQLAGADKEKVVYLDHSDLVLSNRGGILDNIPQASKANMSCMVPSNLAVVTVLGNVLPCFEDFNQKMVMGNIGEQHISDIWHNDKFTSFRKMLKEGHRGKSDLCKNCNNVSVQTEEQYDYVL
What is the function of this protein?
Catalyzes the radical S-adenosyl-L-methionine (SAM)-dependent two-electron oxidation of 2-deoxy-scyllo-inosamine (DOIA) to amino-dideoxy-scyllo-inosose (amino-DOI) in the biosynthetic pathway of butirosin.
What are the official names of this protein?
S-adenosyl-L-methionine-dependent 2-deoxy-scyllo-inosamine dehydrogenase, Butirosin biosynthesis protein N, Radical S-adenosylmethionine dehydrogenase BtrN, RS dehydrogenase BtrN, Radical SAM dehydrogenase BtrN.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily.
Protein: SL3_SISCA
Sequence: MGRLVFVSFSLLVVFLSLSGTAADCPSGWSSYEGHCYKPFNEPKNWDDAERFCLEQAKGGHLVSIESSEEADFVAQLVANNVRRGISYIWIGLRVQGEEKQCSTKWSDGSSVNYENWIEALSKTCLGLEQDTNHKWVNIYCGEINPFVCKA
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec 3, C-type lectin isoform 3.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS4_STRE4
Sequence: MSRYTGPSWKQSRRLGLSLTGTGKELARRNYVPGQHGPNNRSKLSEYGLQLAEKQKLRFSYGMGEKQFRNLFVQATKIKEGTLGFNFMLLLERRLDNVVYRLGLATTRRQARQFVNHGHILVDGKRVDIPSFRVEIGQVISVREKSMKVPAILEAVEATLGRPAFVSFDAEKLEGSLTRLPERDEINPEINEALVVEFYNKML
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: Y4966_PSEA7
Sequence: MPSFDVVSELDKHELTNAVDNAIKELDRRFDLKGKCSFEAKDKSVTLTAEADFMLEQMLDILRSNLVKRKVDSQCMEVKDAYPSGKVVKQEVNFREGIDKDLAKKIVGLIKERKLKVQAAIQGEQVRVTGKKRDDLQEAIALLRGESLGMPLQFTNFRD
What are the official names of this protein?
UPF0234 protein PSPA7_4966.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: 3S154_MICAT
Sequence: MKTLLLTLVVVTIVCLDFGHTLICYNYWTPLDKTTECCGNGVTTCFAKSWNDHRGRRTDRGCGCPNVKPGIHLNCCKTDRCNG
What is the function of this protein?
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
What are the official names of this protein?
Three finger toxin MALT0054C, MALT0054C.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLYA_CHLT3
Sequence: MHLDILKNADPEVYAAIQSELERQTDTLELIASENFTSRAVMEACGSVMTNKYAEGYPGKRFYGGCEFVDVAEDLARDRAKKLFSCEYANVQPHSGSSANMAVIFTFCKPGDTILGFDLSHGGHLTHGSPVNFSGQFYNAHFYGVEKETGRIDMNRVEEKAKEVKPKLIICGASAYSRDWEYAEFRRIADSVDAILMADIAHPAGLIATGLLNDPMPHCHVVTTTTHKTLRGPRGGMILMGKDFENPMGIKAKTKTGERIKMVSELLDAMVMPGIQGGPLMHVIAGKAVAFGEALNPEYKQYMEQVRKNAAAMAEQFISLGYDIISGGTDNHLMLIDLRNKDITGKKTENLLHEAGITVNKNMVPFDDKSPFVTSGFRVGAAAMTTREMKEAEAKTIVKFIDKVISNAGSENISAICQEVKEEVNALCQQFPLYDFVPAS
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_HALS3
Sequence: MTNGKYAARKLKKDRQQRRWSDSEYARRERGLGKKSDPLEGAPQGRGIVLEKVGIEAKQPNSAIRKCVRVQLIKNGKQVTAFCPGDGAISFIDEHDEVTIAGIGGAKGRAMGDLSGVNYKVEKVNGVSLIELVRGNAEKPVR
What is the function of this protein?
With S4 and S5 plays an important role in translational accuracy.  Located at the interface of the 30S and 50S subunits.
What are the official names of this protein?
30S ribosomal protein S12, HmaS12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: PROB_BARHE
Sequence: MAVGLQKLVHYKRIVIKIGSALLVDPQTGLRAEWLKSLISDVANLHQKGVEILLVSSGAIALGRTLLRLPKGALKLEESQACAALGQIELAKTYSDTLAQYGLKTGQILLTLFDTEERRRYLNARATINVLLRFGAVPVINENDTVATSEIRYGDNDRLAARVATMMGADLLILLSDIDGLYTKSPHRDPTAEFIPFIASITSDIEKMADVAHSELSRGGMKTKLDAGKIANSAGTAMIITSGKRMNPLAAIDRGERGSFFAAGEKPVNAWKTWISGHLDPSGILMIDQGAVKALESGKSLLAAGVVAIEGRFNRGDTVAIVDTNGVEIARGLVSYGKDESVRIMGRKSEEIESILGYEARSAMVHRNDMVLRCLTDSA
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_STRP2
Sequence: MSLKDRFDRFIDYFTEDEDSSLPYEKRDEPVFTPVNSSQEPALPMNQPSQSAGTKENNITRLHARQQELANQSQRATDKVIIDVRYPRKYEDATEIVDLLAGNESILIDFQYMTEVQARRCLDYLDGACHVLAGNLKKVASTMYLLTPVNVIVNVEDIRLPDEDQQGEFGFDMKRNRVR
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: JPH1_RABIT
Sequence: MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAAAAADTPTGTRGGFVLNFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGIRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYIKQRLQEGVDAKENPEEKVPAKPPTPKESPHFYRKGTTPPGSPEASPKYSRSPQPSPPKPAKKQNPSSGARLNQDKRGVAEEQVTAIVNKPLTSKAPTKEVGAAVSQSKYSGRHHVPNPSNGELHSQYHGYYVKLHAPQHPPVDAEDDDRSSPSSSALVHKPSPNKWSPPKSVTKPVAKESKAEPKAKKSELAIPKNPASNDSCPSMEREANSGPNSVMIVLVMLLNIGLAILFVHFLT
What is the function of this protein?
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells.  Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.  JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes (By similarity).
What are the official names of this protein?
Junctophilin-1, JP-1, Junctophilin type 1, Mitsugumin-72, Mg72.
What is the protein family that this protein belongs to?
Belongs to the junctophilin family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By similarity).
Protein: NFAC1_PIG
Sequence: MTGLEEDQEFDFDFLFEFNQSDEGAAAAGATAERYSYATTGISSALPLPTAPPTLPAPCHDQQASAAGISAVGSAGHPAGYAGAVDGGPSGYFLPSGGVRPNGAPALESPRIEITSYLGLHHNNGQFFHDVAVEDVLPNPRRSPSTATLSLPNLEAYRDPSCLSPASSLSSRSCNSEASSYESSFSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACSLLGSPRHSPSTSPRTSVTEESWLGARTSRPSSPCNKRKYGLNGRQLFCSPHASPTPSPHSSPRVSVTDDTWLGNTTQYTSSAIVAAINALSTDSSLDLGDGVPVKARKTALDHSPSLALKVEPAAEDLGATPPTSDFPPEEFPPFQHIRKGAFCDQYLSVPQHPYPWARPRSPTPYASPSLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPSVQLHGYVESEPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAVLSNTKVLEIPLLPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPNGRTLSLQVASNPIECSQRSAQELPLVEKQSAASCPVLGGKRMVLTGHNFLQDSKVVFVEKAPDGHHIWEMEAKTDGDLCKPNSLVVEIPPFRNQRITSPVQVNFYVCNGKRKRSQYQHFTYLPANAPVIKTEPSDDYEPALTCGPVSQGLNPLTKPCYGPPLALPPDPSSCLVAGFPPCPQRSAVMSPPPSASPKLHDLSCAPYSKGMAGPGHLGLQRPAGGVLGGQEAPRPGGPHPGAPQLHPLNLSQSIVTRLTEPQP
What is the function of this protein?
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription.  Also controls gene expression in embryonic cardiac cells.  Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.  Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.
What are the official names of this protein?
Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-ATc, NFATc, NFATmac.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Nuclear translocation OF NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11.