PharMolix/UniProtQA huggingface dataset:
Protein: RL20_MYCPN
Sequence: MRIKGGKQTRVRRKKWLKQASGSFGTRHASYKVAKQTVIQAAKYAYRDRRNKKRDFRSLWILRLNAALREQGMTYSVFINLLKKHNIEINRKVLSELAIKEPSKFNLIVQKVKSEQPKAAKPAALGN
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: EX7L_CLOAB
Sequence: MYIKVLSVSELNNYIKRVVDSDYILSNAQVKGEISNFKFHSSGHVYFSLKDEGGKINCIMFRSNAEKLKFIPENGMKVNVKGRVSVYVKDGAYQLYCTEITPEGRGELYEAFEKLKEKLLNEGMFSEEHKRNIPKYPKMIGVITSPTGAAIRDIINVATRRNKSVDMIICPTLVQGVNAPGELIKALDYLNNREDIDTIILARGGGSIEELWAFNDEKLAYAVYNSKKPVVTGVGHETDFTIVDFVSDRRAPTPSAAAEIAVPNINEEMNSFVSLKRALDTSIKTYIQNKCNQLEIAKRMLEKNSPEILIVNGYSSIDNFKYVLDMRIANKIKIEKEKILRYNSILKSNSPINILNKGYSIISDEIGNNISNVDKLKEPDKVHITFKDGKVNAKIDILR
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIXA_ECO7I
Sequence: MKIITCYKCVPDEQDIAVNNADGSLDFSKADAKISQYDLNAIEAACQLKQQAAEGQVTALSVGGKALTNAKGRKDVLSRGPDELIVVIDDQFEQALPQQTASALAAAAQKAGFDLILCGDGSSDLYAQQVGLLVGEILNIPAVNGVSKIISLTADTLTVERELEDETETLSIPLPAVVAVSTDINSPQIPSMKAILGAAKKPVQVWSAADIGFNAEAAWSEQQVAAPKQRERQRIVIEGDGEEQIAAFAENLRKVI
What is the function of this protein?
Required for anaerobic carnitine reduction.  May bring reductant to CaiA.
What are the official names of this protein?
Protein FixA.
What is the protein family that this protein belongs to?
Belongs to the ETF beta-subunit/FixA family.
Protein: LEO1_YEAST
Sequence: MSSESPQDQPQKEQISNNVGVTTNSTSNEETSRSQDDNVKEVNGNDDTKEEEQEEDAELDDLFGDDNDDDDDDDVKKSETEKSDSDSDEDDEGENINHRSRHRESLGLDDDEAEEQAMYTRKFYGEDANNFSDQDETTHTFKEENVELVRHIIPSKANVNETASHNEIFYARIPNFLTIDPIPFDPPSFEAKVNERASNSASREDQLDDRLIDENTVRWRYSRDKDQHVFKESNTQIVQWSDGTYSLKVGEECTDILVNDTSNTFLTVSHDQQELIQCYEGGEIKKTLMFIPTSTNSKIHQKLSKAVIRRNQRQSKGPGTYIVSMDPEVEKKELERKQSQILRDRRRRQLKEKEKQESPDAAFETGFRKQNSPTTYGASRRNEYEEDDFLVDDDEEEEAAFDDEEDDNEEEEEEEDADEENASRLRNLKREGAAMYREEEEEEKDRSETKRRRVAVIEDDEDED
What is the function of this protein?
The PAF1 complex is a multifunctional complex.  Involved in transcription initiation via genetic interactions with TATA-binding proteins.  Involved in elongation.  It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II.  Also has a role in transcription-coupled histone modification.  Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B.  Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.
What are the official names of this protein?
RNA polymerase-associated protein LEO1.
What is the protein family that this protein belongs to?
Belongs to the LEO1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: TPPC9_XENLA
Sequence: MSAPDYMQCAEDHQTLLVVVQPVGVIKNENFFKIYNRVSSVCQVNPMNTQRLLSIRYRHQYPVDNNEWGDFQTHRKVVGLICIAECTSARDLPHTILKFEQQKEAYSSTLYDSRLFLFGFQGEMADQSRIDVASYPSYDNCAAVDKRVEDFIQSLFIVLESKRLDRTSEKSGEKIPLLYVPYEKKDFVGLDPDSRHYKKRCQGRMRKHVGDLCLQAGMLQDALVHYHMAVELLRAVNDFVWLGAALEGLCSASVIHHYPGGTGGKAGTQLRQSVTMSADSFKRHRPGAQEVLIDPGALSTNGINMDASTEIGRAKNCLSPDDIIEKYKEAISYYGKSKAAGVIELEACVKAVRVLAIQKKSMDASEFLQNVVYINLRQLSEEEKIQRYSVLSELYELIGFHRKSAFFKRVAAMQCVAPSIVEPGWKACYKLLLETLPGYSLSLDPKDFSKGTHKGWAAVQMRLLHELVYASRRMGNPALAVRHLSFLLQTMLDFLSDQEKKDVAQSLESYTSKCPGTMDPITLPEGLVLPPVPFTKLPIVRSVKLLDLPVILRPQKVKNLLGQKLSTKSPFIYSPIIAHNRSEEKNKKIDFQWVQGDVCEVQLMVYNPMPFELRVETMGLLTSGVEFEYLPAALSLPAESGLYPVTLVGVPRTTGQITVNGYHTSVCGVYSDCLLDNLPGLKNNGCTVEVIPALPRLQISTSLPRSAHVLQPSSGDEVSTHVSVQLYNGETQKVIIKLENIGAEPLEKLEVTSKTVNTKEKFYGDFLSWDLEPTLSQFPLKPGNTATLTVYIKVKLDFSCQENLLQDLSDDGISVSGLQISSPFRHVSKPRVETKPVNQSDSKSSDFSHVKTLEGILNFKYSGGPGHVEGYYRNLSLGLHVDVEPSVFFTRVSTLPATSTRQCHLLFDVFNSTEHELTINAKDNQELILHAGECQRMAIQVDKFNFEGISDAPSEKQNYHNMKEIEEERQHSKGLEINSKLGIRWKIPTLKREGEASVEGVLNQLVLEHLQLAPLQWDVLVDGKPCDCDAIADCKVGDPIHLEVRLTNCSKNAVGPFALTVIPYQDYQNGVHNHELQDIVTFVGSNTFYIGAVQPMDRSVCFGALLFLYTGDFYLDIKFQDDNSNRELPLSWFCLPSVHIRAIDTLNETKF
What is the function of this protein?
Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex.  May function in neuronal cells differentiation.  May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
What are the official names of this protein?
Trafficking protein particle complex subunit 9, NIK- and IKBKB-binding protein homolog.
What is the protein family that this protein belongs to?
Belongs to the NIBP family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm. Note=Processes and cell bodies of neurons.
Protein: SGLT_VIBPH
Sequence: MSNIEHGLSFIDIMVFAIYVAIIIGVGLWVSRDKKGTQKSTEDYFLAGKSLPWWAVGASLIAANISAEQFIGMSGSGYSIGLAIASYEWMSAITLIIVGKYFLPIFIEKGIYTIPEFVEKRFNKKLKTILAVFWISLYIFVNLTSVLYLGGLALETILGIPLMYSILGLALFALVYSIYGGLSAVVWTDVIQVFFLVLGGFMTTYMAVSFIGGTDGWFAGVSKMVDAAPGHFEMILDQSNPQYMNLPGIAVLIGGLWVANLYYWGFNQYIIQRTLAAKSVSEAQKGIVFAAFLKLIVPFLVVLPGIAAYVITSDPQLMASLGDIAATNLPSAANADKAYPWLTQFLPVGVKGVVFAALAAAIVSSLASMLNSTATIFTMDIYKEYISPDSGDHKLVNVGRTAAVVALIIACLIAPMLGGIGQAFQYIQEYTGLVSPGILAVFLLGLFWKKTTSKGAIIGVVASIPFALFLKFMPLSMPFMDQMLYTLLFTMVVIAFTSLSTSINDDDPKGISVTSSMFVTDRSFNIAAYGIMIVLAVLYTLFW
What is the function of this protein?
Actively transports glucose into cells by Na(+) cotransport.
What are the official names of this protein?
Sodium/glucose cotransporter, Na(+)/glucose symporter.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VE8E2_HPV33
Sequence: MAILKWKLSSNQISTTETADIQTDNDNRPPQAAAKRRRPADTTDTAQPLTKLFCADPALDNRTARTATNCTNKQRTVCSSNVAPIVHLKGESNSLKCLRYRLKPYKELYSSMSSTWHWTSDNKNSKNGIVTVTFVTEQQQQMFLGTVKIPPTVQISTGFMTL
What is the function of this protein?
Plays a role in limiting the replication of viral DNA in keratinocytes.  Recruits the host NCoR/SMRT complex to viral replication foci to mediate repression of both viral replication and transcription.
What are the official names of this protein?
Protein E8^E2C.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E8^E2C protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: ZN233_HUMAN
Sequence: MTKFQEMVTFKDVAVVFTREELGLLDLAQRKLYQDVMLENFRNLLSVGYQPFKLDVILQLGKEDKLRMMETEIQGDGCSGHKNQNEIDTLQEVRLRFLSYEDLICWQIWEQFTSKLTSNQDLIINLQGKRSKLLKQGDSPCQVWTGESSQVSEDENYVIKLQGESSNSIKNQELPLRTTWDFWRKMYLREPQNYQSRCQQIDVKNKLCKCDHCVRQRIAHQHDDHGVHKREKAFSHNNCGKDCVKESSQHSIIQSGEQTSDENGKGLSVGSNLELHQQLHLRDKPHVNVEYGKGIGYSSGLPRHQCFHIGEKCYRNGDSGEGFSQGSHLQPHQRVSTGENLYRCQVYARSSNQNSCLPSHELTHPGEKLCTCGRCGKGFHHSLDFDIHCVDSAGERACKCDVYDKGFSQTSQLQAHQRGHSRDKTYKWEVSDRIFNRNSGLHQRVHTGEKPYKCEVCDKGFSKASNLQAHQRIHTGEKPYKCDVCDKNFSRNSHLQAHQRVHTGEKPYKCDTCGKDFSQISHLQAHQRVHKGEKPYKCETCGKGFSQSSHLQDHQQVHTGENPYKCDVCGKGFSWSSHLQAHQRVHTGEKPYKCEECRKGFIWNSYLHVHQRIHTGEKPYKCGMCGKSFSQTSHLQAHQRVHTGEKPYKCFVCGKGFSKSSLSSDSSESP
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 233.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LPXA_VIBA3
Sequence: MIHETAKIHPAAVIEGDVTIGANVTVGPFTYIAGNVTIGDDTEVMSHVVIKGHTTIGKQNRIFPHAVIGEENQDKKYGGEDTTVVIGDRNVIREAVQIHRGTTQDKATTVIGDDNLLCVNAHVAHDVIVGNHTHIGNNAILGGHVTVGDYAGVMALSAIHPFCSIGAYAYIGGCSAVVQDVLPYVLAQGNHAAPFGLNLVGLKRNGFEKPEIRALQKAYKELYRSGKTLEEAKAALVEMAKEFASVTPMLEMLESSERGIIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTH_CITK8
Sequence: MPGLRPLLSPPASEALLLAQAQQLSGYSLGELAALAGLVAPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVELKTIPVDSLGHPLETTFVCVAPLTGNSGVTWETSHVRHKLKRVLWVPVEGDRSIPLADRRVGSPLLWSPNEEEDQQLRLDWEELMDMIVLGQVERITARHGEFLQLRPKAANAKALTEAIGAQGETILTLPRGFYLKKNFTRTLLARHFLLQG
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYD1A_PYRFU
Sequence: MKNLYLPITIDHIARVEGKGGVEIIIGDDGVKEVKLNIIEGPRFFEAITIGKKLEEALAIYPRICSFCSAAHKLTALEAAEKAVGFVPREEIQALREVLYIGDMIESHALHLYLLVLPDYRGYSSPLKMVNEYKREIEIALKLKNLGTWMMDILGSRAIHQENAVLGGFGKLPEKSVLEKMKAELREALPLAEYTFELFAKLEQYSEVEGPITHLAVKPRGDAYGIYGDYIKASDGEEFPSEKYRDYIKEFVVEHSFAKHSHYKGRPFMVGAISRVINNADLLYGKAKELYEANKDLLKGTNPFANNLAQALEIVYFIERAIDLLDEALAKWPIKPRDEVEIKDGFGVSTTEAPRGILVYALKVENGRVSYADIITPTAFNLAMMEEHVRMMAEKHYNDDPERLKILAEMVVRAYDPCISCSVHVVRL
What is the function of this protein?
Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur-reducing activity.  May play a role in hydrogen cycling during fermentative growth.  Activity not exhibited with NAD.  The alpha and delta subunits form the hydrogenase component that catalyzes the reduction of protons to evolve hydrogen.
What are the official names of this protein?
Sulfhydrogenase 1 subunit alpha, Hydrogenase I large subunit, NADP-reducing hydrogenase subunit HydA, Sulfhydrogenase I subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_BUCA5
Sequence: MAHKKAGGSTRNGRDSNAQRLGVKCFGGQLISAGSIIVKQRGTKFHPGKNVGCGKDHTIFAIVKGKVEFKKKGLKKRTYINIIN
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RS6_HELMI
Sequence: MREYEAVVLVRPNLEEEALQGVIDKFVNLVPQQGGEVVKVDKWGKRRLQYEVKKFKEAFYFLLNFKGEPAVAQELERVMKISDDIIRFLVVRKDEQ
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: HDAC3_ORYSJ
Sequence: MDPSSAGAGGNSLASASCGDAQKRRVCYFYDPEVGNYYYGQGHPMKPHRVRMTHALLAHYGLLAPAKMEVLRPLPARGIDLCRFHSDDYVAFLRAVTPETQLGQVRALRRFNIGPDCPVFDGLYAYCQTYAGASVGAAVKLNHGTHDIAINWSGGLHHAKKSEASGFCYVNDIVLAILELLKLHERVLYIDIDIHHGDGVEEAFYTTNRVMTVSFHKFGDYFPGTGDIRDIGYSEGKYYCLNVPLDDGIDDDSYQSIFKPIISKVMEMYRPGAVVLQCGADSLSGDRLGCFNLSGKGHAECVKFMRSFNVPLLLLGGGGYTIRNVARCWCYETGVALGEELQEKLPYNEYYEYFGPEYSLYVAASNMENRNTNKQLEEIKCNILDNLSKLQHAPSVQFQERIPETKLPEPDEDQEDPDERHDPDSDMVLDDHKPTGHSARSLIHNIGVKREITETETKDQHGKRLTTEHKGPEPMAEDLGSSKQAPTADANAVAVNAPGNARNEPGSSPK
What is the function of this protein?
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).  Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.  Histone deacetylases act via the formation of large multiprotein complexes.
What are the official names of this protein?
Histone deacetylase 3, OsHDAC3.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family. HD Type 1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SELO_SALHS
Sequence: MTLSFTARWRDELPATYTALLPTPLKNARLIWYNDKLAQQLAIPASLFDATNGAGVWGGETLLPGMSPVAQVYSGHQFGVWAGQLGDGRGILLGEQLLADGSTLDWHLKGAGLTPYSRMGDGRAVLRSTIRESLASEAMHYLGIPTTRALSIVASDTPVQRETQETGAMLMRLAQSHMRFGHFEHFYYRREPEKVQQLADFAIRHYWPQWQDVPEKYALWFEEVAARTGRLIAEWQTVGFSHGVMNTDNMSILGLTIDYGPFGFFDDYDPGFIGNHSDHQGRYRFDNQPSVALWNLQRLAQTLTPFIEIDALNRALDRYQDALLTHYGQRMRQKLGFFTEQKDDNALLNELFSLMAREGSDYTRTFRMLSHTEQQSASSPLRDTFIDRAAFDAWFDRYRARLRTEAVDDALRQQQMQRVNPAIVLRNWLAQRAIDAAEQGDMAELHRLHEVLRQPFTDRDDDYASRPPEWGKRLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: LLDD_SALPB
Sequence: MIISAASDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGLCGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWIREFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKAGVANLLDLIEKEMKVAMTLTGAKSISEISGDSLVQELGKSLPTALAPMSKGDAA
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: UBTD1_BOVIN
Sequence: MGNCVGRQRRERPTAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPTPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHTQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD
What is the function of this protein?
May be involved in the regulation of cellular senescence through a positive feedback loop with TP53.  Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.
What are the official names of this protein?
Ubiquitin domain-containing protein 1.
Protein: EFTS_PORPU
Sequence: MTLQISAQNVKALRDKTGAGMMDCKKALEASNGNEEKALDSLRQKGLASANKKSGRTAIEGLLESYIHTGGRIGVLVEVNCETDFVARRPEFQKLAKDIAMQIAACPNVEYVSMMHISDETISLEKRIEAGRDDIKDKPAEMIEKIVEGRIKKRLKELSLLDQMFIRNQDITIEDLINQNIALLGENIKIRRFVRFILGGGEENTKANFADEVADILNKK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, chloroplastic, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NAL12_HUMAN
Sequence: MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
What is the function of this protein?
Plays an essential role as an potent mitigator of inflammation (PubMed:30559449).  Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705).  Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449).  In turn, promotes bacterial tolerance (PubMed:30559449).  Inhibits also the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (PubMed:30902577).  Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity).
What are the official names of this protein?
NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide.
What is the protein family that this protein belongs to?
Belongs to the NLRP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECPA_ECOLI
Sequence: MKKKVLAIALVTVFTGMGVAQAADVTAQAVATWSATAKKDTTSKLVVTPLGSLAFQYAEGIKGFNSQKGLFDVAIEGDSTATAFKLTSRLITNTLTQLDTSGSTLNVGVDYNGAAVEKTGDTVMIDTANGVLGGNLSPLANGYNASNRTTAQDGFTFSIISGTTNGTTAVTDYSTLPEGIWSGDVSVQFDATWTS
What is the function of this protein?
Part of the ecpRABCDE operon, which encodes the E. coli common pilus (ECP).  ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition.  Major subunit of the fimbria (By similarity).
What are the official names of this protein?
Common pilus major fimbrillin subunit EcpA, MatB fimbrillin.
What is the protein family that this protein belongs to?
Belongs to the EcpA/MatB fimbrillin family.
What are the subcellular locations of this protein?
Fimbrium.
Protein: SYGA_BUCAI
Sequence: MKNYHNNFHKLITILQEYWLQQGCTIFQPLDLPIGAGTFHNITFLGTIGPEPINAAYIQSCRRPSDGRYGENPNRLQHYYQFQVIIKPPPNNIQNIYLNSLYLLNIDEKIHDIRFVEDNWENPTLGAWGIGWEVWLNGMEITQFTYFQQVGGLECKPVSVEITYGLERIAMHMQNKSNVYDLIWNEYNHKKITYGDIFQQNEREQSQYNFQYSDVNFLFDCFKKYELEAKKLINLKEPLLLVSYEKILQANHIFNLLDARKSLSSNERQSYILRIRKLTSQVAIKYLNLRKNLGFPLCHKKREIHDKENIIN
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_CAMJR
Sequence: MIFAANLKCNHTRASFKIYAEILNKTMGAKCDDIIVFPPSVAFLENENNFIQGAQNFYPCVNGAFTGELGKEHLDEFGIKCVLIGHSERRALGDEEFIKAKFDFAKEHGYKIVFCIGENLDTKNSGKTLEFLKKQLEIIDLNYEKLIIAYEPIYSIGTGVSAQSTDIAKVLEFLASLTKVPLLYGGSVNENNIKEILSVNHCGGVLIGSAALKVENFIKLIKG
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPI10_DEBHA
Sequence: MAYNNSVRKRKKDIQDANGFHRDQTIDKKSRATNKLEESLPTFKVFIVLFFIRLLNSLTIKTFFQADEYYQCLEPAYNFVFGSGYITWEWEEGIRSSIHPLIYALGYKMVSYVHFDDKPIILIPKVIGALIASIGEVYLYKFSKKFTKNEKLARLTLILSLLSPFNWYIITRSFSNSFEMVLTTIAFTYWPWDNVISYKDISMSCIIAFISCIVRPTNGIIWLYLGINFMIKNYKLEKQSGKLMKLILILSIELILILLVNTGLDYIFYGKTTFPLYNFVEFNVIRNLSIFYGVAPWHFYLFQGVPIILMTYLPWLLHSAIVLKKYKSLLGQVAILMIGGFSLIDHKEIRFIYPLQPIFMLMVAYSIHETKHKFQRLYKFLVPVIIILNLIIAIFFTQVHERGVIDIVQYLRNNPDIESFGFLTPCHSTPWQSHINNPNLVNKSWFLTCEPPLHLTTTSLKEIKSYRDESDQFYDNPAQFLSEHFQSFADSRNTGASNWPSRLIIFEPLENFMDDFLRGSNYFECERFFNSYFHWDDRRKGDIIVYCQI
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 3, GPI mannosyltransferase III, GPI-MT-III, Glycosylphosphatidylinositol-anchor biosynthesis protein 10.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 22 family. PIGB subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYK_YERPN
Sequence: MSEQKPQVAEQAQELNSELQARREKLAVLRGKGIAFPNDFRRENLSDQLHAEFDSKENEELEALNIDVTVAGRMMTRRIMGKASFVTLQDVGGRIQLYVSRDDLPEGVYNEEFKKWDLGDILGARGKLFKTKTGELSIHCSELRLLTKALRPLPDKFHGLADQETRYRQRYLDLIANDESRHTFKVRSQVMSGIRSFMVEKGFMEVETPMMQVIPGGASARPFVTHHNALDIDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSPRHNPEFTMMELYMAYADYKDLIVLTEELFRTLTETILGSSVVQYGEQTFDFGKPFAKLTMKEAICKYRPETNVADLDDMDKAVAIAESLGIKVEKSWGLGRIQCEIFEETAESHLIQPTFITEYPAEVSPLARRNDDNPFITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQVSAKEAGDDEAMFYDEDYITALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPVK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPC3_YARLI
Sequence: MHTSIQRIQQTFSQASTVLSIIAAIVFVVSYIQLVVANVWSLPEANFNLRGSKAARRFSRQYGANDPKKGKENVALKFDLDADLSPLFNWNTKLVFAYLTATYDGKRDDIVNEITIWDQIITDKDDSHIKLKGANSKYSLYDVEESFRNRNATVKLHWNIQPHVGAKIYGSLDATKGSIKFPQLV
What is the function of this protein?
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.  Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface.  Essential for viability.
What are the official names of this protein?
Signal peptidase complex subunit 3, Microsomal signal peptidase subunit 3.
What is the protein family that this protein belongs to?
Belongs to the SPCS3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: D2HDH_ARATH
Sequence: MMMQKLRRSGEFIRFGCKSLISSRPNKDSVSRSVSGFVNHYKSKGKLFELSDGNYKTELHHPCISRNVGMLLQQYKCFGSSAASLIQRNPLFSSLDSKDVSYFKEILGEKNVVEDKERLETANTDWMHKYKGSSKLMLLPKNTQEVSQILEYCDSRRLAVVPQGGNTGLVGGSVPVFDEVIVNVGLMNKILSFDEVSGVLVCEAGCILENLATFLDTKGFIMPLDLGAKGSCHIGGNVSTNAGGLRLIRYGSLHGTVLGLEAVTANGNVLDMLGTLRKDNTGYDLKHLFIGSEGSLGIVTKVSILTQPKLSSVNLAFIACKDYLSCQKLLVEAKRNLGEILSAFEFLDNNSMDLVLNHLDGVRNPVSSSENFYILIETTGSDETNDREKLEAFLLKSLEKGLVSDGVIAQDINQASSFWRIREGITEALQKAGAVYKYDLSLPVEEIYNIVNDLRGRLGDLANVMGYGHLGDGNLHLNISAAEYNDKLLGLIEPYVYEWTSKHRGSISAEHGLGVMKANEIFYSKSPETVALMASIKKLLDPKGILNPYKVLPHSLFSN
What is the function of this protein?
Catalyzes the oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate.  May be involved in the catabolism of propionyl-CoA derived from beta-oxidation.  Involved in degradation of lysine for the supply of carbon and electrons to the ETF/ETFQO complex during dark-induced sugar starvation.
What are the official names of this protein?
D-2-hydroxyglutarate dehydrogenase, mitochondrial, AtD-2HGDH.
What is the protein family that this protein belongs to?
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
What are the subcellular locations of this protein?
Mitochondrion.