PharMolix/UniProtQA huggingface dataset:
Protein: SNAB_RAT
Sequence: MDNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSAAGNAFCQAAKLHMQLQSKHDSATSFVDAGNAYKKADPQEAINCLNAAIDIYTDMGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTMDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK
What is the function of this protein?
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
What are the official names of this protein?
Beta-soluble NSF attachment protein, SNAP-beta, N-ethylmaleimide-sensitive factor attachment protein beta.
What is the protein family that this protein belongs to?
Belongs to the SNAP family.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein.
Protein: HISX_BACFN
Sequence: MKLIKYPDRSQWNEILKRPVLETENLFDTVRNIINRVRAGGDRVVMEYEAVFDKAELTSLAVTSAEIEEAEKEVPIELKAAIYLAKRNIETFHSAQRFEGKKVDTMEGVTCWQKAVAIEKVGLYIPGGTAPLFSTVLMLAIPAKIAGCKEIVLCTPPDKNGKVHPAILFAARLAGVSKIFKAGGVQAIAAMAYGTESIPKVYKIFGPGNQYVTAAKQLVSLRDVAIDMPAGPSEVEVLADESANPVFVAADLLSQAEHGVDSQAMLVTTSEKLQTEVVYEVERQLGYLTRRDIAEKSLASSKLILVKDMEEALELTNAYAPEHLIIETKDYMEVAGQIVNAGSVFLGAFSPESAGDYASGTNHTLPTNGYAKAYSGVSLDSFIRKITFQEILPSGMSAIGPAIEVMAANEHLDAHKNAVTVRLEEIRK
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: SCN2_MESMA
Sequence: MKLSLLLVISASMLIDGLVNADGYIRGSNGCKVSCLWGNDGCNKECRAYGASYGYCWTWGLACWCEGLPDDKTWKSESNTCGGKK
What is the function of this protein?
Binds to sodium channels (Nav) and inhibits them (By similarity).  Recombinant ANEP delays the convulsion seizure of insect models by 18% and shows anti-neuroexcitatory activity.
What are the official names of this protein?
Anti-neuroexcitation peptide 2, BmKANEP2, Anti-neuroexcitation peptide II, ANEPII.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TGT_XANOM
Sequence: MSRLQFQLQATDGHARRGRLTFPRGTVETPAFMPVGTYGSVKGILPEHIRALGAEIILGNTFHLYLRPGLDVIGDHGGLHGFARWDGPILTDSGGFQVFSLAHRRKITEQGVTFSSPTDGARVFLGPEESMKIQKVLDSDIVMIFDECTPYPATEDLARRSMELSLRWAQRSRDAHDGLGNDAALFGIVQGGVHPDLRSRSLDGLQSIGFDGYAIGGLAVGEPEHERNAMLEHLHPRLPAECPRYLMGVGRPEDLVEGVARGVDMFDCVMPTRNARNGHYFTSFGTVRIRNAKYERDLDTIEPGCGCHACSSGYTRSYLRHLDRCNEMLAPMLGTLHNLWYYEKLMADMRAAIASGTFVEFRRSFYAARGATTPPLPGETS
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NIR_BETPN
Sequence: MSSLSVRFLSPPLFSSTPAWPRTGLAATQAVPPVVAEVDAGRLEPRVEEREGYWVLKEKFREGINPQEKLKLEREPMKLFMEGGIEDLAKMSLEEIDKDKISKSDIDVRLKWLGLFHRRKHHYGRFMMRLKLPNGVTTSAQTRYLASVIRKYGKDGCADVTTRQNWQIRGVVLSDVPEILKGLDEVGLTSLQSGMDNVRNPVGNPLAGIDIHEIVATRPYNNLLSQFITANSRGNLAFTNLPRKWNVCVVGSHDLFEHPHINDLAYMPAIKDGRFGFNLLVGGFFSPRRCAEAVPLDAWVSADDIILVCKAILEAYRDLGTRGNRQKTRMMWLIDELGIEGFRSEVVKRMPNQELERAAPEDLIEKQWERRELIGVHPQKQEGLSYVGLHIPVGRVQADDMDELARLADTYGCGELRLTVEQNIIIPNIENSKLEALLGEPLLKDRFSPEPPILMKGLVACTGNQFCGQAIIETKARALKVTEEVQRQVAVTRPVRMHWTGCPNSCGQVQVADIGFMGCMARDENGKPCEGAAVFLGGRIGSDSHLGNLYKKGVPCKNLVPLVVDILVKHFGAVPREREESED
What are the official names of this protein?
Ferredoxin--nitrite reductase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RPOA_SINFN
Sequence: MIQKNWQELIKPNKVDFTSSGRTKATLVAEPLERGFGLTLGNALRRVLLSSLRGAAVTAVQIDGVLHEFSSIPGVREDVTDIVLNIKEIAIKMDGDDSKRMVVRKQGPGVVTAGDIQTVGDIEILNPNHVICTLDEGAEIRMEFTVNNGKGYVPAERNRSEDAPIGLIPVDSLYSPVKKVSYKVENTREGQVLDYDKLTMSIETDGSVTGEDAIAFAARILQDQLSVFVNFDEPQKEAEEEAVTELAFNPALLKKVDELELSVRSANCLKNDNIVYIGDLIQKTEAEMLRTPNFGRKSLNEIKEVLASMGLHLGMEVPSWPPENIEDLAKRYEDQY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: ITF2_RAT
Sequence: MTSRDLGSHDNLSPPFANSRIQSKTERGSYSSYGRENVQGCHQSLLGGDMDMGNPGTLSPTKPGSQYYPYSSNNARRRPLHSSTMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYSSSKPAASTFSSSFFMQDGHHSSDPWSSSSGMNQPGYGGMLGNSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGIIGPSHNGAMGSLGSGYGTGLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDTANHMGQM
What is the function of this protein?
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif.  Involved in the initiation of neuronal differentiation.  Activates transcription by binding to the E box (5'-CANNTG-3').  Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity).  Interacts with the CCAAT displacement protein (CDP2) to bind the tyrosine hydroxylase enhancer.
What are the official names of this protein?
Transcription factor 4, TCF-4, Immunoglobulin transcription factor 2, ITF-2, RITF-2, R8f DNA-binding protein, SL3-3 enhancer factor 2, SEF-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: NAGB_CORDI
Sequence: MEIVITPTKDDAARIAADILEEYAREGKTLGLATGSTPLGTYQELIRRHNEEGLSFAECQAFTLDEYVGLPREHEQSYYSTIRREFTSHIDIPDEKVFNPDGTAEHPGQAAQEYDRLIVEKGGVDIQILGIGTDGHIAFNEPTSSMASRTRIKTLHPDTVRDNSRFFNGNESQVPHHVMTQGIGTIREARHLLMLCFGENKADAVKAMVEGPVAAVCPASVLQLHEHATVIVDEAAAAKLEHTQYYRYALENKPDWQRF
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: XYLA_PECAS
Sequence: MQAYFEQIEKVRYEGSQSSNPFAFRHYNPDQEILGKRMADHLRFAVAYWHTFCWNGSDMFGVGSFARPWQQSGDALELAKRKADIAFEFFQKLSVPYYCFHDVDVAPEGNSLKEYLHNIAVITDVLAEKQQDSGVKLLWGTANCFTNPRYGAGAATNPDPDVFAWAATQVFTAMNATKTLGGENYVLWGGREGYETLLNTDLRQEREQIGRFMQMVVEHKHKIGFQGTLLIEPKPQEPTKHQYDYDVATVYGFLKQFGLEKEIKVNVEANHATLAGHSFHHEIATAVALGVFGSVDANRGDPQLGWDTDQFPNSVEENTLIMYEILKAGGFTTGGLNFDAKVRRQSTDRYDLFHAHIGAMDTMALALKAAARMIEDDKLNQLVAKRYAGWNGELGQQILQGNASLESLAQYAESHQLAPQHQSGQQELLENLVNRHLFG
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_CORGL
Sequence: MKLILTAAVENLGVAGDIVEVKNGYGRNLLLPRGLAIVATPGAEKQIEGIKRAQEAREIRDLDHAREVKVALEALEGVTIAVRTSESGKLFGSVKTDDIVDAVKAAGGPNLDKRAIVLPKNLVKTTGKYQVEAKLTDGIVSRVKFEVVAA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: HARS1_HUMAN
Sequence: MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC
What is the function of this protein?
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198).  Plays a role in axon guidance (PubMed:26072516).
What are the official names of this protein?
Histidine--tRNA ligase, cytoplasmic, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_STRZJ
Sequence: MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGNRERIQIFEGVVIARKGAGISENYTVRKISNGVGVERIFPIHTPRVEKIEVVRYGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RL35_BACC4
Sequence: MPKQKTHRGAAKRFKKTGSGKLKRSHAYTSHLFANKSTKAKRKLRKAGVVSAGDFKRIRQMLDNLK
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: NAGB_CLOTE
Sequence: MKVLIKDNYDELSEVAALEILELIDKKPDCVLGLATGSTPVGTYQKLIEYYKKGKVDFSKVTSFNLDEYRGLNGEHPQSYKFFMNNTLFNHINIDKKNTFILDGLSNDIEKECIEYDKKIDNKGGIDLQILGIGGNGHIGFNEPSEELSISTHLTKLKTKTIKDNSRFFNSEEEVPTEAITMGIGSIMKARKIILLINGEVKAEIVKKLINGNVSTKVPASLLHLHPNCTVILDKEAAKFI
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: DTD_ANOFW
Sequence: MRVVVQRAKDAKVTVAGEVVGEIDFGLVLLVGITHDDTEEDAAFVADKIAHLRIFEDEHGKMNVSLIDVGGAILSISQFTLYGDCRKGRRPNFMDAAKPEHAKHIYEAFNEQLRQKGIRVETGVFGAMMDVMLTNVGPVTLIVESK
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COFD_METTH
Sequence: MWRQSMITVLSGGTGTPKLLQGLVRVVDPEEITVIVNTVENGYLSGVYVAPDVDTVLYTLAGIINEETWYGVEGDTFITHETLRELGCPELLRIGDRDRAFKIQKTLLLGEMPLHRAVEIQSRALGVESRVLPMSNEDSDIVIVTDEGDMEFHEFLVERRSEPGVLDVRFSRVKPAPGVLDAIESADMVILGPSNPVTSIGPIINMEGVTDSLRKVNVSAVSPFTGGRPFSGPAGKFMEAKGYDASSLGVAEIYADFLDRLVIDETDSDLKGEIEKLIKEVTITKTNMENIGDKIMLARILLGEIL
What is the function of this protein?
Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
What are the official names of this protein?
2-phospho-L-lactate transferase.
What is the protein family that this protein belongs to?
Belongs to the CofD family.
Protein: RS2_STRPJ
Sequence: MAVISMKQLLEAGVHFGHQTRRWNPKMAKYIFTERNGIHVIDLQQTVKYADQAYDFMRDAAANDAVVLFVGTKKQAADAVAEEAVRSGQYFINHRWLGGTLTNWGTIQKRIARLKEIKRMEEDGTFEVLPKKEVALLNKQRARLEKFLGGIEDMPRIPDVMYVVDPHKEQIAVKEAKKLGIPVVAMVDTNTDPDDIDVIIPANDDAIRAVKLITAKLADAIIEGRQGEDAVAVEAEFAASETQADSIEEIVEVVEGDNA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: SECR_CHICK
Sequence: HSDGLFTSEYSKMRGNAQVQKFIQNLM
What is the function of this protein?
Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis.  Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells.
What are the official names of this protein?
Secretin.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: MCM_RHIME
Sequence: MTEKTIKDWEALAEKELRVSPEGLVWHTPEGIDVKPLYTSDDMSGIGHLNSLPGFEPFVRGPRATMYAGRPWTVRQYAGFSTAEASNAFYRRNLAAGQQGVSVAFDLATHRGYDSDHPRVQGDVGKAGVAIDSVEDMKILFDGIPLDRISVSMTMNGAVIPILASFIVAGEEQGVSRDKLSGTIQNDILKEFMVRNTYIYPPEPSMRIVADIIEYTAKEMPKFNSISISGYHMQEAGATLVQELAFTLADGREYVRAALAKGLNVDDFAGRLSFFFAIGMNFFMEAAKLRAARLLWTRIMQEFKPEKASSLMLRTHCQTSGVSLQEQDPYNNIVRTAFEAMSAVLGGTQSLHTNSFDEAMALPTDFSARIARNTQLILQHETGVTKVVDPLAGSYYVESLTNELAEKAWGLIEEVEALGGMTKAVNAGLPKRLIEEAATRRQAAVDRAEEVIVGVNKYRLENEQPIDILQIDNAAVRTAQVKRIEETRRRRDSQKMKQALDALADVARSGKGNLLAAAVEAARARATVGEITDAMREAFGDYTAIPEVVTDIYGKAYEGDPELGVLAGRLGEATKRLGHKPKIMVAKLGQDGHDRGAKVIASAFGDIGFDVVAGPLFQTPEEAADLALAEEVTVIGVSSLAAGHRTLMPQLAEALKKRGGEDIIVVCGGVIPRQDYDYLMENGVAAVFGPGTQVLDAARAVLDLIEGKRRNV
What is the function of this protein?
Radical enzyme that catalyzes the transformation of methylmalonyl-CoA to succinyl-CoA.  Is required for growth on the polyhydroxyalkanoate degradation pathway intermediates 3-hydroxybutyrate and acetoacetate as sole carbon source.
What are the official names of this protein?
Methylmalonyl-CoA mutase, MCM.
What is the protein family that this protein belongs to?
Belongs to the methylmalonyl-CoA mutase family.
Protein: YEEX_SALPC
Sequence: METTKPSFQDVLEFVRLFRRKNKLQREIQDIEKKIRDNQKRVLLLDNLSDYIKPGMSVEAIQGIIASMKSDYEDRVDDYIIKNAEISKERRDISKKLKAMGEMKHADVKAE
What are the official names of this protein?
UPF0265 protein YeeX.
What is the protein family that this protein belongs to?
Belongs to the UPF0265 family.
Protein: SSRP_PSEMY
Sequence: MAKQKKHPQGTIALNKKALHDYFVEQKFEAGVALAGWEVKSLRAGKAQLVDSYVLLKDDEAWLMGAHITPLKTASTHVIADPIRTRKLLLHKRELDKLFGAVQQKGYTCVALSLYWKQHLVKCEIALAKGKKDFDKRHVEKERDANREVQRAMRSKGKDD
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: SNUT2_HUMAN
Sequence: MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRVKREFEPASAREAPASVVPFVRVKREREVDEDSEPEREVRAKNGRVDSEDRRSRHCPYLDTINRSVLDFDFEKLCSISLSHINAYACLVCGKYFQGRGLKSHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTKQQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYIQIWKRRDNDETNQQGA
What is the function of this protein?
Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367).  Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint.  Does not have ubiquitin-specific peptidase activity (PubMed:18728397).
What are the official names of this protein?
U4/U6.U5 tri-snRNP-associated protein 2, Inactive ubiquitin-specific peptidase 39, SAD1 homolog, U4/U6.U5 tri-snRNP-associated 65 kDa protein, 65K.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYGB_STRMU
Sequence: MTKNLLVELGLEEMPAYVVKPSIKQLRQKMGQFLETNRLSFEKIEMFSTPRRLAIRVVHLADQQSDYSEDFKGPAKKIALDADGHFTKAAQGFVRGKGLTTDAIEFREVKGEEYVYVTKNEAGKPAKEVLGGLIDVLQSLTFPVNMHWANHTFEYIRPVHTLVVLLDDEALDLNFLDIKSGRISRGHRFLGQETQIASAASYETDLRAEFVIADAKEREDMIIEQIREIEKTYNVSVEIDEALLSEVLNLVEYPTAFMGSFDEKYLELPEEVLVTSMKTHQRYFVVRDQTGKLLPNFISVRNGNEQFIENVVKGNEKVLLARLEDGEFFWREDQRLQIADLVEKLKLVTFHEKIGSLYEHMMRTKQIAAYLAEQADLTDQEKAEIERAASIYKFDLLTGMVGEFDELQGIMGEKYATLAGESQAVATAVREHYLPISSDGQLPDSKVGAILAVADKLDTLLSFFSVGLIPSGSNDPYALRRATQGIVRILDKFGWEIPLDRLVANLYQFDFDSLTYQNQADVLAFIRGRVEKMIDKSVPKDIREAVLDSSTHIVRLEVEAAAALAEKADEDHFKASIESLSRVFNLAEKSNHNEMVDTSIFENEYEQELFDAVEELHFTEDMTDNVDRLFVLSPIIDAFFDNTMVMVDDEAVKKNRLNLLDRLAQKANTIAAFNEIRTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OUTS_DICD3
Sequence: MHVSSLKVVLFGVCCLSLAACQTPAPVKNTASRSAASVPANEQISQLASLVAASKYLRVQCERSDLPDDGTILKTAVNVAVQKGWDTGRYQSLPQLSENLYQGLLKDGTPKATQCSSFNRTMTPFLDAMRTVR
What is the function of this protein?
Out proteins are required for the translocation of pectate lyases and cellulases across the outer membrane.
What are the official names of this protein?
Pilotin OutS, Lipoprotein OutS.
What is the protein family that this protein belongs to?
To K.pneumoniae PulS.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: POLS_ONNVI
Sequence: MEFIPAQTYYNRRYQPRPWTQRPTIQVIRPKPRRRRPAGQLAQLISAVSRLALRTVPQKPRRTRKIKKQKQVKQEQQSTRNQKKKAPKQKQTQKKKRPGRRERMCMKIENDCIFEVKHEGKVTGYACLVGDKVMKPAHVKGTIDNADLAKLAFKRSSKYDLECAQIPVHMKSDASKFTHEKPEGYYNWHHGAVQYSGGRFTIPTGAGKPGDSGRPIFDNKGRVVAIVLGGANEGTRTALSVVTWNKDIVTKITPEGSVEWSLALPVMCLLANTTFPCSQPPCAPCCYEKKPEETLRMLEDNVMQPGYYQLLDSALACSQHRQRRNARENFNVYKVTRPYLAHCPDCGEGHSCHSPIALERIRSEATDGTLKIQVSLQIGIKTADSHDWTKLRYMDSHTPVDADRSGLFVRTSAPCTITGTMGHFILARCPKGETLTVGFVDSRRISHTCMHPFHHEPPLIGREKFHSRPQHGKELPCSTYVHTTAATTEEIEVHMPPDTPDYTLMTQQAGNVKITVDGQTVRYKCKCDGSNEGLITTDKVINNCKVDQCHTAVTNHKKWQYNSPLTPRNSEQGDRKGKIHIPFPLVNTTCRVPKARNPTVTYGKNRVTLLLYPDHPTLLSYRAMGRIPDYHEEWITSKKEISITVPAEGLEVTWGNNDPYKYWPQLSTNGTAHGHPHEIILYYYELYPTTTIAVLAAASIVVASLVGLSLGMCICARRRCITPYELTPGATIPFLLGILCCVKTAKAASYYEAATYLWNEQQPLFWLQLLIPLSAAIVVCNCLKLLPCCCKTLTFLAVMSIGARTVSAYEHATVIPNTVGVPYKTLVSRPGYSPMVLEMELQSVTLEPTLFLDYITCEYKTITPSPYVKCCGTAECKAKNLPDYNCKVFTGVYPFMWGGAYCFCDAENTQLSEAHVEKSESCKTEFASAYRAHTASVSAKLRVFYQGNNITVSAYANGDHAVTVKDAKFVIGPLSSAWSPFDNKIVVYKGEVYNMDYPPFGAGRPGQFGDIQSRTPDSKDVYANTQLILQRPAAGAIHVPYSQAPSGFKYWLKEKGASLQHTAPFGCQIATNPVRAVNCAVGNIPVSIDIPDAAFTRVTDAPSVTDMSCEVASCTHSSDFGGAAVIKYTASKKGKCAVHSLTNAVTIREPNVDVEGTAQLQIAFSTALASAEFKVQICSTQVHCSATCHPPKDHIVNYPSPHTTLGVQDISTTAMSWVQKITGGVGLVVAIAALILIIVLCVSFSRH
What is the function of this protein?
Class II viral fusion protein.  Fusion activity is inactive as long as E1 is bound to E2 in mature virion.  After virus attachment to target cell and endocytosis, acidification of the endosome would induce dissociation of E1/E2 heterodimer and concomitant trimerization of the E1 subunits.  This E1 trimer is fusion active, and promotes release of viral nucleocapsid in cytoplasm after endosome and viral membrane fusion.  Efficient fusion requires the presence of cholesterol and sphingolipid in the target membrane.  Fusion is optimal at levels of about 1 molecule of cholesterol per 2 molecules of phospholipids, and is specific for sterols containing a 3-beta-hydroxyl group.
What are the official names of this protein?
Structural polyprotein, p130.
What are the subcellular locations of this protein?
[Capsid protein]: Virion. Host cytoplasm. Host cell membrane. Host nucleus. Note=Shuttles between the cytoplasm and the nucleus. SUBCELLULAR LOCATION: [Spike glycoprotein E2]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [6K protein]: Host cell membrane; Multi-pass membrane protein. Virion membrane; Multi- pass membrane protein. SUBCELLULAR LOCATION: [Spike glycoprotein E1]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein.
Protein: CPFC_STRR6
Sequence: MKKAILMMTFGSPEEITFEGVADFFTNIRRGVRPQDHEIQTLYDNYVRIGGTPLQKITRQEVTLVEARLGNEYSVYFANKFSSPFIPDVIGQMEADGIEQCICLILEPHYSFYSVMGYEKFLESKQIQFLVIKDWYQEEALLNYWADEIAKILKEEVKQDSFKVIFSAHSVPIFALDFGDPYIDQIFENSKLVAEKLGLSSEQYTNTWQSESDIGIPWIKPDVLEYLREQTEHPDHYIFVPISFISEHIEVLFDNDVECYDLCQEFGVNYHRPPMPNTDSRLIDALVNTVRVNENQEFKEFLPEEETFDELVPSDETKNILAESEDLQMPEFVKKLIEKKGRENVKMPYLIKKMLEKAGKLPKE
What is the function of this protein?
Involved in coproporphyrin-dependent heme b biosynthesis.  Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
What are the official names of this protein?
Coproporphyrin III ferrochelatase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROQ_SYNY3
Sequence: MTTVWKVLVLHGPNLNLLGQREPGIYGSLTLGEIDACLREDGVDLEAEVSTFQSNSEGQLVTAIHGALGNYHGIVFNAAAYTHTSIALRDALAAVQLPCVEVHLSNIHKRESFRHISHIAPVAIGQICGFGLNSYRLGLRALVDYLNGQADS
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.