PharMolix/UniProtQA huggingface dataset:
Protein: TIG_MARMS
Sequence: MQVSVETTSPIERVLTISVPAARVDEKVNSEVAKTAKTIRIDGFRKGKVPVSVVKKRYGQGIRLDAVEQIMRDAYVEAIQKESIQPAGMPSIEPKNFAEGADLEFVVKIEVYPEVTLADNSAIKVDRVVSDVTEADVDTMLETLRKQNAEWSAVERESADGDQVTIDFVGYLGDEAFDGGAAEGHKLVLGSNTMIPGFESGILGAKAGEERTISVTFPEDYQAENLKGKEATFKITVSEVAEQILPELNDAFVEKFGLEEATVAALRAEVRKNMERELNQAIKSKLKNALFEGLSSINEVEVPSALVDQEVDALRKQAAQQFGGQGFDASQLPAELFQEEAKKRAKLGLLISEVIKKDDLKVDDDRVRAFLEDMAQAYQEPQQVIDFYLKNKEQLAQVQSAVLEEQVVDKLLESAQVTEVTLGYEDAIKPNAQAEEAGEEA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: CCKN_MACFA
Sequence: MNSGVSLCVLMAVLAAGALTQPVPPAEPAGSGLQRAEEAPRRQLRAVQRTDGESRAHLGALLARYIQQARKAPSGRMSIIKNLQNLDPSHRISDRDYMGWMDFGRRSAEEYEYPS
What is the function of this protein?
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut.  Its function in the brain is not clear.  Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
What are the official names of this protein?
Cholecystokinin, CCK.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: YNVD_SCHPO
Sequence: MSAVITLTPLNESFQTKKLVISPSTIYKIGRHTNKSTSPSPSNLFFNSKVLSRQHAELWLDKDTLSVYIRDVKSSNGTFVNETRLSPENKPSAPCKLNSGDIVDFGVDIYNEDEIVHQKVSAQVRIVVRGATFATTPARSLDSEVMLDSIMRQMVFQYQRCVELNENLESLENGVEEVSKSLSWLETGKTRDNRNNHHYSRKSSPHISSLAVPSTKHLDGERDRNLKRSTSPLSSSPFVTEAALNEAELAKTNLEAWKARAFTAEARLSSKNKSWQEKKYLVLSPFFIAVAGIIVYMGYWR
What are the official names of this protein?
Uncharacterized protein C3H7.13.
What are the subcellular locations of this protein?
Nucleus.
Protein: RBSB_SALTI
Sequence: MNMKKLATLVSAVALSATVSANAMAKDTIALVISTLNNPFFVSLKDGAQKEADKLGYNLVVLDSQNNPAKELANVQDLTVRGTKILLINPTDSDAVGNAVKMANQAKIPVITLDRQATKGDVVSHIASDNVLGGKIAGDYIAKKAGEGAKVIELQGIAGTSAARERGEGFQQAVAAHKFNVLASQPADFDRTKGLNVMQNLLTAHPDVQAVFAQNDEMALGALRALQTAGKADVMVVGFDGTPDGEKAVKDGKLAATIAQLPDQIGAKGVEVADKVLKGEKVQAKYPVDLKLVIKQ
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Binds ribose.
What are the official names of this protein?
Ribose import binding protein RbsB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 2 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ENL06_ARATH
Sequence: MGGQKIVLLSIFVCFYVFSLVSCTEFEAGGENGWIIPQSSNQSDIFNQWASKNRFKVGDTIRFKYKKDSVLVVTEDEYKKCQTTKPELYSNHDDTVFKLDRPGLFYFISGVSGHCEQGQKMIIKVMEVESTPQSPPPSSSLPASAHKKNHAVRKTSRFLGAGLVTISILVITVFSLV
What is the function of this protein?
May act as a carbohydrate transporter.
What are the official names of this protein?
Early nodulin-like protein 6, AtENODL6, Phytocyanin-like protein ENODL6.
What is the protein family that this protein belongs to?
Belongs to the early nodulin-like (ENODL) family.
Protein: AMIF_PSEU2
Sequence: MASGLGGLNKSPNGVVIGLAQLALPDPHTREALWMQTQKVVGMVAKARRSNPGMDLIVFPEYSLHGLSMSTAPEIMCSLDGPEVMALREACKTHRIWGCFSIMEANPHGNPFNSGLIVDDLGEIRLYYRKLHPWVPVEPWEPGDLGIPVCDGPRGSKLALIICHDGMFPEMARECAYKGADIMLRTAGYTAPIRHSWKITNQSNAFTNLMQTASVCMCGSDGTFDSMGEAMFVDFDGTIMAEGGGRADEIVCCELRPDLVREARVHWGVENNIYQFGHRGYVAVKGGARDCPYTYMHDLSAGRYRLPWEDDVVHTDGSSCGFAAPERDFKPTPGSWKE
What is the function of this protein?
Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.
What are the official names of this protein?
Formamidase, Formamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: YIDD_CHLFF
Sequence: MSFKSLLKNLPKFFFLGLIHIYRWTISPLLGSPCRFFPTCSQYALQALKHHGCIKGLGFTIKRIGKCGPWHPGGVDLVPMTTLEESLDISPATNDDDSCDSQA
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CYC_TETPY
Sequence: GPKEPEVTVPEGDASAGRDIFDSQCSACHAIEGDSTAAPVLGGVIGRKAGQEKFAYSKGMKGSGITWNEKHLFVFLKNPSKHVPGTKMAFAGLPADKDRADLIAYLKSV
What is the function of this protein?
Electron carrier protein.  The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase.  Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: MUTL_COXBU
Sequence: MYIRRLNDQTANQIAAGEVVERPASVVKELIENSIDAHASCIRVDILQGGAKQIRIQDDGDGIHPEDLVLALERHATSKIAKIDDLQDITTLGFRGEALASISAVSRLTLTSRQKNAEMGYRISNISHKIMTPVPAAHPQGTTIDVQDLFYNTPARRKFLRSPATEFQHIRRIIERLALSHFTTEFLLHHNEKEIIHFKSATTISGQENRIKSILGDVFMQSALAIEFSQSGLTLKGYIAEAAYTRSQPDLQYIYVNGRFVRDKLVAQALRQAYHDVLFHGRHPAYVLYLEIDPAFVDINVHPTKHEVRFRDPQWVRDFLIHAVKTALAQAKPGIVHPLPQSTAEYNPITNFAPTPLIEGQGNLSLIQEQPAPYTQTIVHKHPLGHALAQLQGIYILSQNEKGLVIVDMHAAHERILYEKMKKQLAEVGLAMQSLLVPINLSLNPQEITAWQTNKALFARLGFEIESFGPDKIVVRRHPSLLKPKNLENLIRDVLADLITHNTTSRVGERINAALATLACHAALRAPHYLTIEEMEALLREMEKTEHGGLCNHGRPTWKQFDIAELDTFFLRGQ
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: MIAB_CROS8
Sequence: MTKKLHIKTWGCQMNEYDSSKMADLLETTHGFTLTDVAEEADILLLNTCSIREKAQEKVFHQLGRWKTLKEKNPDVIIGVGGCVASQEGDHIRDRARYVDIIFGPQTLHRLPEMINQVKGTRSPVVDISFPEIEKFDRLPEPRAEGPTAFVSIMEGCNKYCTYCVVPYTRGEEVSRPSDDIVLEIAQLAAQGVREVNLLGQNVNAWRGENYDGTTGTFADLLRLVAAIDGIDRIRFTTSHPIEFTDDIIEVYRDTPELVSFLHLPVQSGSDRVLNMMGRTHTALEYKAIIRKLRAARPDIQISSDFIVGFPGETQQDFEQTMKLIAEVNFDMSYSFIFSARPGTPAADMVDDVPEEEKKQRLYILQERINQQAMAWSRRMLGTTQRILVEGTSRKSIMELSGRTENNRVVNFEGSPDMVGKFVDVEITEVFPNSLRGKVIRTEDEMGLRVVESPESIIARTRKENELGVGIFQP
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1065_METJA
Sequence: MEKIKIGDRYVGKGEPTFIIAEGGLNHNGDIDIGKELVKEAKKCGADAIKFQSYHTEDFISKKSEYYELFKSLELSEEEFYELKEYAEKIGIMFISTPLDLKYVDILNKMNVPAFKIASGDLTFYPLLEKVAKTGKPVILSTGMSDIGEIWEAVKVLENNGCRDIILLHCISSYPTPYEDVNLNAIKTLKSIFNIPVGYSDHTLGILAPVVSVALGADVIEKHFTLDKNMEGPDHALSADPEEFKEMVNNIRLVEKMLGSGEKIPMPSERDVIVEARRSIVAKRNIKKGEYLSVDNISFKRPGRGIETKYLSIILNRKIKNDKEEDDIIYWDDLLGD
What are the official names of this protein?
Uncharacterized protein MJ1065.
What is the protein family that this protein belongs to?
To B.subtilis SpsE.
Protein: MTSA_STRP6
Sequence: MGKKMSLILGAFLSVFLLVACSSTGTKTAKSDKLKVVATNSIIADMTKAIAGDKIDLHSIVPIGQDPHEYEPLPEDVEKTSNADVIFYNGINLEDGGQAWFTKLVKNAQKTKNKDYFAVSDGIDVIYLEGASEKGKEDPHAWLNLENGIIYSKNIAKQLIAKDPKNKETYEKNLKAYVAKLEKLDKEAKSKFDAIAENKKLIVTSEGCFKYFSKAYGVPSAYIWEINTEEEGTPDQISSLIEKLKVIKPSALFVESSVDRRPMETVSKDSGIPIYSEIFTDSIAKKGKPGDSYYAMMKWNLDKISEGLAK
What is the function of this protein?
Part of an ATP-driven transport system.
What are the official names of this protein?
Metal ABC transporter substrate-binding lipoprotein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: LICA2_HAEIF
Sequence: MQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYKPEEVFHFLHQHSIPFSSIGGMTNQNVLLNISGVKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSNTLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSRMDKLSAVFWQFEEINKDIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAFKLLEELP
What is the function of this protein?
Mediates phase variation of the LOS 6A2 and 12D9 epitopes.  Phase variation of H. influenza LOS epitopes expressed by LicA is determined by a translational switch.
What are the official names of this protein?
Protein LicA.
What is the protein family that this protein belongs to?
Belongs to the peptidase S49 family.
Protein: RL9_CHLTA
Sequence: MKPQLLLLEDVDGLGRSGDLVVAKPGYVRNYLLPKGKAVVASAGTLRLQAKLQEQRLLQAAADKEESLRLAEMLRSIVLDFQVRVDSENNMYGSVTVNDMISAAEQQGVVLTRKNFPRSHSGIKNLGRHVVGLKLKEGVTADLHLEVRADHEIIEQKELQSAEEQEG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: MNMG_BART1
Sequence: MQSYDVIIVGGGHAGCEAASASARVGAQTALLTHKISALGTMSCNPAIGGLGKGHLVREIDALDGLMGRAADAAGIQFRLLNRRKGPAVRGPRTQADRQLYKEAIQKFLKEQENLTLVEDEVIDLIVKDHCVSGVILKKQGTIFSGAVVLTTGTFLNGFIHIGDKTWAAGRMGDPASVQLAERLKNYHIKLGRLKTGTPARLSKKTIDWDRLSKQQADENPVPFSFLTEKIEQPQIECAITRTNAQTHQIIRDNIHRSALYSGNIEGLGPRYCPSVEDKIVKFGERDGHQIFLEPEGLNDDTVYPNGLSTSLPEDVQISFLKTIEGLENATVLQPGYAIEYDFVNPQQLTKSLELRSLPGLFLAGQINGTTGYEEAAAQGLLAGLNAARKVGKLDEIFISRSTAYIGVMVDDLVSRGVCEPYRMFTSRAEFRLSLRSDNADTRLTPLAQEWGIVSKVRWDCYQKKQQRLDQARSICKNLFLTPNEASAHGLHVNHDGIRRSAYDFLAYPHMTLERLSHFWPQLQAIDSKTVESLEIEAQYAVYLDKQAQDIASLQRDERLEIPSSLDIQAISGLSNELKSKIQEVSPRSIADAQKIDGMTPAALSLIITYIQRQRREKAKKA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEUAB_DANRE
Sequence: MEGGRCAQVSSVPASPSSGHRHRAALILARGGSKGIPLKNIKNLAGVPLIGWVLRAALDSDVDSVWVSTDHDEIERVAKLWGAKVHRRSPEVSKDSSSSLETIQEFIRLRPEVDVICHIQATSPCLHPHHINEALQKITHQGFSYVLSVVRRHQFRWEELQENEDRNPKSFNINVAQRPRRQDWPGELYENGSFYFSTRKAWESGLTELGRIAYYEMPPEFSVDIDVDIDWPVAEQRVLRFGYFGREENAAVRLFLCKVSGCLTNGQIYMSVSGEDLVTINARDVAGIQMLQKENIEVILISSVNEPLSRGVLEKVSQRAGCGLSFTEQRNALEMQKLMDKRKLHWDQVAFMGSESEDVEIMSQAGLNGVPSDAPVAELIAAKYTCQRAGGHGAVREFAEYILSMKRKSSREENHERIDKHNF
What is the function of this protein?
Catalyzes the activation of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) to cytidine 5'-monophosphate 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (CMP-KDN), a substrate required for the addition of sialic acid.  Also has weak activity towards N-acetylneuraminic acid (NeuNAc) and N-glycolylneuraminic acid (Neu5Gc).
What are the official names of this protein?
N-acylneuraminate cytidylyltransferase B, CMP-sialic acid synthetase 2.
What is the protein family that this protein belongs to?
Belongs to the CMP-NeuNAc synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PESC_ASPTN
Sequence: MAKIKKKGTSGQAKNYITRTQAVRKLQISLPDFRRLCIFKGIYPREPRNKKKASKTSTPNTTFYYTKDIQYLLHEPLLRKFRDQKAVAKKIARSLGRGEVGDASRLEKNHAPKLTLDHIIKERYPTFIDALRDLDDALSLLFLFANLPSTSHVPPKTIALCQRLCHEFQHYLITTNSLRKSFLSIKGIYYQATIQGQDIMWLVPYRFVQRVNGDVDYRIMATFVEFYTTLLGFVNFRLYSSIGLRYPPKFDTRSDENGAELAAFTLEGRAVANAAKTIEGSNKQSNNSSNQEVSRDVQAKVDKVIKTAGLDKTKDEQTVEATDENTDAIDRFEPAAPEADTLPQPDISGEEAGALFAPFTFYISREAPKAPLEFILRAFGCKRIGWDAVMGDGAFTHNEADTRITHQIVDRPSLPEGALPAVPAAKEGAVPAVRPGTRIPGRTYIQPQWVWDCINEGKLLRPDLYAPGETLPPHLSPWVKPSKGAYDPRATLAEQEEEGEAEMAGEEEEEESDEEMEEAPETKKADAKADESESEDEDESVDGGMDVADSDDDESESGQEEEDFGGFDDNEAASESEDEEEAARTQHQKELEAEAAGLPFSSNGATDDAKKKKSSQAKKIAAKKRKEEEELERQKMMMSRKKRKLLEKMMYSNKKQSEEAAKLRSKRRKLEKTGEK
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Pescadillo homolog, Nucleolar protein 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the pescadillo family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: ENO_SULIA
Sequence: MINRFSIEKVKGLEIIDSRGNPTIRVFVRTNDGVESFGDAPAGASKGTREAIEVRDENGLTVKRAVDIANYIIDPALHGIDVREQGIIDKILIDIDSTENKSKLGGNTIIATSIAALKTASKALGLEVFKYIAGPRLPKIPIPLLNIINGGLHAGNKLKIQEFIVLPIKFNTFKEAFFAAIEVYRNLKGLISERYGKIYTAVGDEGGFSPPLEETREALDLIYTSINNAGYQGKIYMGMDAAASDFYDPKKEKYIIDGKELNPNQLLEFYLDLAKEYPIVYLEDPFEENSFDMFGELQNKLNSTIVTGDDLYTTNIKYLKIGIEKRSTKGVIVKPNQVGTISETFEFTNLARRNSIKLVTSHRSGETEDNFIAEFAVGIESDFIKTGAPARGERTSKYNKLLEIENKFGLEYGGKYFYL
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: VM2G_TRIAB
Sequence: EAGEDCDCGSPANPCCDAATCKLLPGAQCGEGLCCDQCSFMKKGTICRRARGDDLDDYCNGISAGCPRNPLHA
What is the function of this protein?
Inhibits fibrinogen interaction with platelet receptors.  Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.
What are the official names of this protein?
Disintegrin albolabrin, Platelet aggregation activation inhibitor.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TAO3_YEAST
Sequence: MASRFTFPPQRDQGIGFTFPPTNKAEGSSNNNQISIDIDPSGQDVLEEINEAPLNTFPLHQSVTDAPIIDIPSPTDMSEGTSLNNQLLLRQQQQQGTGEGQALPPTFVEEQSDQNKISMLLPEQKQQRMQESAPPDITAKSVAEDYVTTLRQQMATDWKSPSEYALHILFTKFIRYAENKLNMCLQQLDMAEPPIVEILGEGVDPSFDEIIKSLGHIAKKKPKPVIDAMMFWRKTKSEAANSASEEMEKLLKEYEFEKAHPSQAHFLMNRRLSRSSSNTTSKYKHNNNTNNLPGMKRHVSSSFNNKVPLIKASSSNNSATSSPSIANSQLKSLENTIEVAKEEAFLADRKSLISIYILCRVLNEIVKQASSNEEEDLSDKLEEIVFTQLKTTDPLSISTSLIKSSNWNSFAELLGSMSEKKFLSVSDRFIADLEKIPAYIPPELEPSTHLLILGMRYLKLRNYPLEKFEESADFMKSLSKFFAKTENFPVCLAYAEVTNQLLLPLAGSLTAEVNHPTWVEAMSTLLNTAKRLQADSKYWVSGFKLTVSILCASPPDLFSKQWLSLLEANASKVKSKSLNERIIFAVGLSRLVWVYLYRCPETLNNTTRTLTKLLQLYLNTRKKENWITGDFGLLNPLTDALISIGFLHPNFLMEQALIPLIRQSFNGSNLENINYEKLILTINTYKGLLVTKERPRFPEDDNRLYELNLNNITVNQVQEASSINHTEISDYFYKLFLLLDSSIGSEVWSPENQHQKQSSNAFSPFGFSFSNDNDSSKNKSLYVILFGTIIEAIPCCLSISRTIPYKSTIEILSRNAVHSEVIISSSSQNALRALASKKNPYTLITWFAKYSFDFDEKTQSSYNMSYLSSKEYNRLLILYVELLECWLEEFQSSNKEENKKETGLDGIRLLPIDAEQEESNETEKLEWKNTVTVIEEVEGNGLFFLCSHDAKIRRLGIQILRIIFKFDEAMMEKTEKLSNGHSRSSSHFAADRGTRLIDLLNECNTTTLINPHKATLSAVEKTRFSRLNSKYKRGLLIKLAESEYGVDAALWQRAFPKLLALVFKTCPMAMALCRSIVCIRLVQVHEIILRVANDVDFKLKNVLPETIVNQWKLYLIAACTSLTSTFDQKLHIPSNIPQHGRKKSQQIFTVQHQKIKSAKSIFKMVLPLLNAKYIMIRDAIITGLSSMNINIFKAYVEAIDVFLVAWKEGSSNNQIRVEMFHILTILSPYLKSDMIFNDEWILRKLSEFLQKTKQFLEKDSVQISYEYQSLRSYFAGLILSYYMAVREHPLIDELFPFQARASCFNFLKEWCGYGEYEPISEERYAIMIKNTESGRDRTAITTGIEFQKNRLQMIVLETMVVLCSDPITQTLDDDLELPIVISFDTEDLLAWIEALFDSDNTTVKNLGVRALENLLDKNRENFKLFRDVAFQCVSHHSHPSVAVLYYTTLCKSVLKLDNLVLDEDELVSLGLYGLVADKEDTRTFAVDLLSAVETKLHNSSYTKVFKERLANSSKTVYKSTAKEISSIFAELLSQDLCLRIFSSLVRILDLFPFEIKRDLLVLMVPWVNKFTLKSLEELDTFMVLNNLFYITIDLNDSLPNEVEQLWISLGKGNSFQNIHVSLEYIINSSMNHCNPLFVQYARDIVLYLANIPGGIGLLDTLLNNLEPKYMVPLAKHTFNEPMNNNKYSFLGNIWERLNYNGKRIIFSKAQLSIIFLVNLLTNLSESVKAKIPLLLHMSICLLDHYVPLIHESACKIASTLIFGLAPSHEKSEETVKLLRNKHALWSYDNLMKKGARSPKTMDLLIRNIISIFSDLDEFQVTWQRIALKWATTCSVRHIACRSFQIFRSLLTFLDQEMLRDMLHRLSNTISDGNVDIQGFAMQILMTLNAIMAELDPTNLISFPQLFWSITACLSSIHEQEFIEVLSCLSKFISKIDLDSPDTVQCLVAIFPSNWEGRFDGLQQIVMTGLRSANSLEITWKFLDKLNLLKDSRIIANTESRLLFALIANLPRFLNAMDRKDFTGIQVAADSLIELANAYKQPSLSRLIDSLAKNKFRSKKDFMSQVVSFISRNYFPSYSAQTLVFLLGLLFNKIGWIRVQTLEILKYVFPLIDLRRPEFIGVGADLISPLLRLLFTEYEAKALEVLDCVPNVSGSKMDKDVLRITMGNKDVKDGDNATTTLFGLPEDSGWSVPMPTMTAATTRHNVHAVFMTCGTGKSDEVSAHGSDDMDAVIEFHADGDYELGRMDTIVEFHADGDYDLGRMDTNDSISVAEEKDASLSHMWAELDNLDSFFTKDTNVPNISSKMGMGIPHGRSDSIETTRTDQTFSFESAPQLYDKKVSVILNRSLSRTPSNVSFKTHLADSFAVKINRNGKPRI
What is the function of this protein?
Seems to play a role in cell morphogenesis.
What are the official names of this protein?
Cell morphogenesis protein PAG1, Protein TAO3.
What is the protein family that this protein belongs to?
To S.pombe mor2.
Protein: TPIS_NITSB
Sequence: MILAANFKMNHTRASTKAYIERLNAYGKQTDIDIAVFPPATALDQYETFADIGAQNAYAAEHGSFTGEIGLQQLQEFGIETVLLGHSERRHIFYESQEMIARKFAFYKERGFTIYYCLGETLQTRKKGFEAIRELLQSQLEGIDTAYENFVIAYEPVWAIGTGVAAKPEEIEEVLAYLASLTDAPLLYGGSVKPANIKEVLSIPKCDGALIGTASWDVENFIKMIEIAKEMR
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_SHEWM
Sequence: MLAKRIVPCLDVREGKVVKGVQFRNHEIVGDIVPLAARYAEEGADELVFYDITASAHDRVIDKSWVSRVAERIDIPFCVAGGISSIEQAREKLAFGADKISVNSPALSDPSLIQRLQDEFGRQCIVIGIDSYYDEASDSYRVKQFTGDESATKDTQWFTQNWVEEVQKRGCGEIVLNVMNQDGVRQGYDLKQLSIIREICDVPLIASGGAGTMEHFKDVFEIAKVDAALAASVFHKGIIDINELKTYLAQHKIPTRR
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PORED_HUMAN
Sequence: MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEPSRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYKSKFVSYPKHRKAFLPFLF
What is the function of this protein?
Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol (PubMed:20637498).  Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:20637498).  Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (PubMed:20637498).  Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (PubMed:17986282, PubMed:26855069).
What are the official names of this protein?
Polyprenol reductase, 3-oxo-5-alpha-steroid 4-dehydrogenase 3, Steroid 5-alpha-reductase 2-like, Steroid 5-alpha-reductase 3, S5AR 3, SR type 3.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RMD2_XENTR
Sequence: MSHSENKTLFLGVLAGAAGLSLTLLLLKRNRPRYLLGFSEIWSSAKETSAVQDNQGAVLILQGRQLQMLDKLGSLLKSVEELKEEVKFLKDTLPKLEEQIRDELRGKNDARKISPQHKGIKRKKSETTKGAVEYPSSEEAESEGGYITAHTDTELESDEERGLKHLNAENAKVTEEKAELLSVLYQADTGHCGSEPDKQDTFRMMLDNKEKYGNKVEFLWRLARAYGDMFDMTSDVEEKKNYAANGKSIAGKAIQLEDCSAESHRWFAIMCGYLSEYESVQDKIKNGYLFKEHLDKAIELDPKDPLQYYLLGRWCYAVSQLSWIERKVAAALFGNPPTATIQEALQNFLKVEEMHPGYSKYNYVFLAKCYKDLGQKSVALKYCDEASAMTAANKEDKDAQKEMDTLMVSLKQ
What are the official names of this protein?
Regulator of microtubule dynamics protein 2, RMD-2, Protein FAM82A1.
What is the protein family that this protein belongs to?
Belongs to the RMDN family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: B2MG_SAIUS
Sequence: MARSVVAALLVLLSLSGLEAIQHAPKIQVYSRHPAENGKPNYLNCYVSGFHPSDIEVDLLKNGQKIENVEHSDLSFSKDWSFYLLYYTEFTPNEKDEYACRVSHVTFPTPKTVKWDRNM
What is the function of this protein?
Component of the class I major histocompatibility complex (MHC).  Involved in the presentation of peptide antigens to the immune system (By similarity).
What are the official names of this protein?
Beta-2-microglobulin.
What is the protein family that this protein belongs to?
Belongs to the beta-2-microglobulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CD4_MOUSE
Sequence: MCRAISLRRLLLLLLQLSQLLAVTQGKTLVLGKEGESAELPCESSQKKITVFTWKFSDQRKILGQHGKGVLIRGGSPSQFDRFDSKKGAWEKGSFPLIINKLKMEDSQTYICELENRKEEVELWVFKVTFSPGTSLLQGQSLTLTLDSNSKVSNPLTECKHKKGKVVSGSKVLSMSNLRVQDSDFWNCTVTLDQKKNWFGMTLSVLGFQSTAITAYKSEGESAEFSFPLNFAEENGWGELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQLKETLPLTLKIPQVSLQFAGSGNLTLTLDKGTLHQEVNLVVMKVAQLNNTLTCEVMGPTSPKMRLTLKQENQEARVSEEQKVVQVVAPETGLWQCLLSEGDKVKMDSRIQVLSRGVNQTVFLACVLGGSFGFLGFLGLCILCCVRCRHQQRQAARMSQIKRLLSEKKTCQCPHRMQKSHNLI
What is the function of this protein?
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.  In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex.  The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins.  Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs).  In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.  LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells.  In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway.  Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
What are the official names of this protein?
T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.