PharMolix/UniProtQA huggingface dataset:
Protein: XPT_BACC1
Sequence: MKVLQEKILNEGKVLSGDVLKVDAFLNHQIDPVLMQEIGKEFAKRFKEENITKIVTIESSGIAPAVMAALELGVKVIFARKRKSLTLQDNMYVANVYSFTKQETNEISLSRNHIDESDRVLIIDDFLANGQAALGLMSLVEQAGASIAGIGIVIEKAFQDGGKKLREQGVRVESLAEIASLDNGTVTFVQHETAEVK
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_CANLF
Sequence: MAPSRKFFVGGNWKMNGRKKNLGELITTLNAAKVPADTEVVCAPPTAYIDFARQKLDAKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
What is the function of this protein?
It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
What are the official names of this protein?
Triosephosphate isomerase, TIM, Methylglyoxal synthase, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIBT_SALTY
Sequence: MAKIGENVPLLIDKAVDFMASSQAFREYLNKTPPRDYVPSEVPSESAPIYLQRLEYYRRLYRPKEEERG
What are the official names of this protein?
Uncharacterized protein YibT.
Protein: FLIE_RHIEC
Sequence: MISSVQNVSNLSMTRALGAVDTENSASSAATTMPGTAGAANGLSFASVLGGMASDAVNSLKGAESMSFAGIKGTATTREVVDSMLQAEQTLQTAIAIRDKVVSAFLEVTKMQM
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: PFPC_ENTH1
Sequence: MKLFVLLCVFVLCLASQEKQQDREIPVLCPVCTSLVGKLIDLVLGGAVDKVTDYLETLCAKADGLVETLCTKIVSYGIDKLIEKILEGGSAKLICGLIHAC
What is the function of this protein?
Forms pores in the cell membrane of host cells (PubMed:7715451).  Has antibacterial activity against M. luteus, no activity against E. coli (PubMed:7715451).  Implicated in the cytolytic activity of the parasite (PubMed:7715451).
What are the official names of this protein?
Pore-forming peptide amoebapore C, EH-APP C.
Protein: NRK1_MOUSE
Sequence: MKRFVIGIGGVTNGGKTTLAKSLQKHLPNCSVISQDDFFKPESEIDIDENGFLQYDVLEALNMEKMMSAVSCWMENPGSSAGPAALESAQGVPILIIEGFLLFNYKPLDTIWNRSYFLTVPYEECKRRRSTRVYEPPDPPGYFDGHVWPMYLKHRQEMSSITWDIVYLDGTRSEEDLFSQVYEDVKQELEKQNGL
What is the function of this protein?
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
What are the official names of this protein?
Nicotinamide riboside kinase 1, NRK 1, NmR-K 1, Nicotinic acid riboside kinase 1, Ribosylnicotinamide kinase 1, RNK 1, Ribosylnicotinic acid kinase 1.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family. NRK subfamily.
Protein: CDC61_METMA
Sequence: MIKAQSLDGLFEKLLDGKSIFKNKEVLRPSYTPDLLLHRNDQINSLATILVSALRGETPSNVLIYGKTGTGKTAVTRYVGKELERVSEDKSIFCSVVYINCEVIDTQYRLLANLARHFEEEVPMTGWPTDQVFMKFKEAIDSREQVIIIILDEIDKLIKKGDDVLYNLSRINTDLRKAKVSMIGVSNDLKFTEFLDPRVKSSLGEEELIFPPYDAEQISDILKQRAKMAYNDGVLGEMVIPLCAAFAAQEHGDARRALDLLRVSGEIAERENQPQVLEEHVRRAQEKIEIDRVVEVVRTLPTQSKLVLYSIILLRNRGREGKNVTTGEMYNVYRQLCHHIDVDILTQRRVTDLMSELDMLGIVNAVVVSKGRYGRTKEISLSVPVENTRKVLLEDYRLKPLVDFKASVFNKMFS
What is the function of this protein?
Involved in regulation of DNA replication.
What are the official names of this protein?
ORC1-type DNA replication protein 1.
What is the protein family that this protein belongs to?
Belongs to the CDC6/cdc18 family.
Protein: LEU1_NITWN
Sequence: MTPANKSDKDRVVIFDTTLRDGEQCPGATMTFEEKIEVAEMLDGMGVDIIEAGFPIASVGDFEAVAEIARNARNAVIAGLARAIPGDIARAGEAVRHARRGRIHTFVSTSPIHLAHQMRKSEAEVLEIITATVKQARNLVEDVEWSAMDATRTPIDYLCKCVEAAIAAGATTINLPDTVGYAVPDEYRRMFKTIRERVPSADKAIFSVHCHDDLGLAVANSLAGVEGGARQVESTINGIGERAGNAALEEVVMAIKTRADVMPYWCNVESTMLTRASKMVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMLKNAQTYEIMTPESVGVKQTSLVMGKHSGRHAFQHKLEELGYKLAENQLQDAFVRFKALADRKKDIYDEDIIALVDEEMAATHDRIKLSSLTVIAGTHGPQRATMKLTVSGQTRIEEAEGNGPVDAVFNCIKRLVPHEAKLELYQVHAVTQGTDAQAEVSVRLSQDGRAMTSKAADPDTLVASAKAYLGALNKIVMKHQRDVPAAAAS
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: LPXH_PSEMY
Sequence: MILLISDLHLEEKRPDITRAFLHFLATRARQAEALYILGDFFEVWIGDDGMTPFQHEIAGALRELSDSGTRIYLMHGNRDFLIGKRFCREAGCTLLGDPHRVQMNGEPVLLMHGDSLCTLDVGYMKLRRWLRNPLSLLILRNLPLATRQKLARKLRNESRAQTRMKASEIVDVTPEEVVRVMGEYDVRTLIHGHTHRPAVHELEVNGQPARRIVLGDWDRQGWALQVDGEGFNQAPFELTPA
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1261_RICBR
Sequence: MNRNIFITLLISLLALSGCSGDTCIDPDDFGFIKFNISSRYDPSEVTSRQEGDQVAPWRDSAYKVNGYPLTIMVRPWDYMSGDKNTSGMLSAWCPWYGQQNNFTTLAEFCVRLRPCQFTDGKMCPTPTPRDAPINNAPCILTNGVGLYFLIADKGSNPNMSPDSQRSPKGITQHLGEPVASQDYEFYSISSTGKFLQAGGINYQYGCTSLPCDQASNYAQSSLYFKILDKFYDDNSGQYRVVIKSGVSDTRPDPLQFLTNLIKNELFGTSDKDPGIVRQTYQQIIETPGYRLSVSALLTLYIMFTGFSFLIGNINMTHVELVVRILKVSVVSILLSTSKAWTFFHDYLFVFFVEGLAQILQIVQDASTGQSLLSLLISPQTLSKLFSLLFVDPLGFIYIILYLIALYFIFLLIFKATIIYLTALITIGMIITMAPIFICFMLFNITRSLFENWLRQLISYAIQPIILFVGIAFIGMIIKTEIQSTLGFAVCKKDFPDLGPINQIFGSFTEDLDSSIGNSIFYWWFPVPMKGGIENFTQADILVPEDYTKKDGTKCLAYQCIDKRYIQLPFLDLVKDANRISNFINGKFVQLDGLLLIFVSIYLLSKFNDTAISTASFIAGTSGNLTSIQAVNQQSYDSIMKQVNRPINYATGVISKPINRMQEQTSMFFAEKYQGLMMSRLENKALSSSANKAVQNEVKRKYGIDHKDVNMQAGADYKNGISKLLDNKTFLPKGGDLDVKKLATMNFGQLRDEFAKNKYGAKNYSSLTSDQKLELDKFMKSDLGEKGKSAKSLRELASDANFTRDYQSAYKYAHKEMSGRGVGLFGKNIGVLRSWQEMENRMKTKRELKEQKRVAIGEKIYAGYTGLKRDALTAIVGKDLRDKYEGNLTSAEWHDFDYNDPQLRTYSESLKDKERAREVKELQMQINKETLAVQEDILSPEYLARLKRPSDVEYYQELGQRRLIHEVRDRLSEGSDPVIMGDRFMQEKATDDQMRTMIDNAHQKHAEFIDQDRYTRRQEHYDIMHEKAQENIDRTYKEIKDHFKRDDIKLEEMPALIAQYEREKPIESFDSKTELSLDKRIEEAVSNFNINAKNYEYSASVLNNIEERKQAITDEVNTQIDRINKYRENAKMPQYQKPVENSGRKLRKLEDHLRNMK
What are the official names of this protein?
Uncharacterized lipoprotein RBE_1261.
What is the protein family that this protein belongs to?
Belongs to the TrbL/VirB6 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.
Protein: SYD_LISMH
Sequence: MEKRTSYCGELNEAHIGQSVVLHGWVQKRRDLGGLIFIDLRDREGIVQVVFNPEFSKEALEIADSVRNEFVVTIKGTVHARGEKAINEKLATGKVEVLAEEITILNTSKTPPFYIEDGVNVSDELRLKYRYLDLRRPEMNNIFKMRHTVTRTFRNKLDALGFFDIETPYLTKSTPEGARDYLVPSRVYPGNFYALPQSPQILKQLLMTAGFDKYYQIVRCFRDEDLRGDRQPEFTQIDLETSFLTKEEIQAITEDMLVDVVKEAKNITIDKPFPRMTYKEAMDRFGSDKPDIRFGLELQNVSDVVKDVDFKVFQSAIENGGEVKAINAKSAAANFSRKDLDALGVFVANYGAKGLAWLKVEASELKGPIAKFFPEDKAADLKAALQAEDGDLLLFAADKADIVAASLGALRNKLGKDLNLINEEELAFLWVTDWPLFEYDEEAGRYVSAHHPFTLPKEEDIPLLETDSSKVMAEAYDIVLNGYEIGGGSLRIYKKEVQESMFRALGFTDESAKEQFGFLMDALEYGTPPHGGIALGLDRIVMILAGRNNLRDTIAFPKTGSAVDPLTNAPGEVSAAQLAELKLETVKKETN
What is the function of this protein?
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
What are the official names of this protein?
Aspartate--tRNA ligase, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THI44_PHYPA
Sequence: MSSQAGNVGSSSSSLAGVRMVVSPKAQLRHARLPAASASMYSDAKYDLNNYKFEPIKESIVAREMTRRYMTEMITHADTDVVVVGAGSAGLSCAYELSKNPNVKVAIIEQSVSPGGGAWLGGQLFSAMVVRKPAHRFLDEIEVPYEELENYVVIKHAALFTSTIMSKLLARPNVKLFNAVAAEDLIIRGDRVSGVVTNWALVAQNHNTQSCMDPNVMEAKVVVSSCGHDGPFGATGVKRLRSIGMIESVPGMKCLDMNAAEDAIVKHTREVVPGMIVTGMEVAEIDGSPRMGPTFGAMMISGQKAAHLALKALGLPNELDGNYKLNVHPELVLASTDDETASA
What is the function of this protein?
Involved in biosynthesis of the thiamine precursor thiazole.  Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate.  The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate.  The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.  May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
What are the official names of this protein?
Thiamine thiazole synthase 4, chloroplastic, Thiazole biosynthetic enzyme 4.
What is the protein family that this protein belongs to?
Belongs to the THI4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: C209B_MOUSE
Sequence: MSDSTEAKMQPLSSMDDDELMVSGSRYSIKSSRLRPNSGIKCLAGCSGHSQVPLVLQLLSFLFLAGLLLIILFQVSKTPNTERQKEQEKILQELTQLTDELTSRIPISQGKNESMQAKITEQLMQLKTELLSRIPIFQGQNESIQEKISEQLMQLKAELLSKISSFPVKDDSKQEKIYQQLVQMKTELFRLCRLCPWDWTFLLGNCYFFSKSQRNWNDAVTACKEVKAQLVIINSDEEQTFLQQTSKAKGPTWMGLSDLKKEATWLWVDGSTLSSRFQKYWNRGEPNNIGEEDCVEFAGDGWNDSKCELKKFWICKKSATPCTEG
What is the function of this protein?
Probable pathogen-recognition receptor.  May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments.  May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens.  Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.
What are the official names of this protein?
CD209 antigen-like protein B, DC-SIGN-related protein 1, DC-SIGNR1, OtB7.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: PTH_BRUA2
Sequence: MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYKMTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNEWLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAEMLKKLLGKKD
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_DESVV
Sequence: MGKQCEVCGKKPQVGHHVSHSNIKTKRRFEPNLQSVRHQLPSGEVKTVTVCTRCLRSGAVTKPVVRKSA
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RECX_HAEI8
Sequence: MSSLAFNYIVNLLSRREYSEFELRNKMQEKNFSEEEIDDALSLCQAKNWQSDRRFSENYLNSRSQKGCGVGRIRQELRQLKGVSSDIIDEVLMESEIDWYEMAENLLRKKFPNYNEQQTSKMKQKIWQYMLSHGFRSDEFADLIGQNQSEWD
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNP2_SACS2
Sequence: MNSIQLIIDIILILWILILTVLYFKRRQLNVDIVKNKKIIRAKRYIVFYVISEYKVKGDDLERVIRNSLKDLLGSVWLNIANPKVVTYREDTQEGIISTNRVGYKAVLASLPFAKEINNNKILIVPRRTTGSLKKAKKLIGLK
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 2, RNase P component 2, Pop5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIDD_DEIDV
Sequence: MSLASRGLVRVIRAYQRELSPRKPSPTCRFIPTCSQYAVEAIERHGALKGGWLATWRIMRCNPLVPGGVDPVPERFPQGRKTHP
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: OBG_STAAC
Sequence: MFVDQVKISLKAGDGGNGITAYRREKYVPFGGPAGGDGGKGASVVFEVDEGLRTLLDFRYQRHFKASKGENGQSSNMHGKNAEDLVLKVPPGTIIKNVETDEVLADLVEDGQRAVVAKGGRGGRGNSRFATPRNPAPDFSEKGEPGEELDVSLELKLLADVGLVGFPSVGKSTLLSIVSKAKPKIGAYHFTTIKPNLGVVSTPDQRSFVMADLPGLIEGASDGVGLGHQFLRHVERTKVIVHMIDMSGSEGREPIEDYKVINQELAAYEQRLEDRPQIVVANKMDLPESQDNLNLFKEEIGEDVPVIPVSTITRDNIDQLLYAIADKLEEYKDVDITVEEEESVGINRVLYKHTPSQDKFTISRDDDGAYVVSGNAIERMFKMTDFNSDPAVRRFARQMRSMGIDDALRERGCKNGDIVRILGGEFEFVE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAE_STAAB
Sequence: MPKVIGLTGGIASGKSTVSELLSVFGFKVVDADKAAREAVKKGSKGLAQVREVFGDEAIDENGEMNRRYMGDLVFNHPEKRLELNAIIHPIVRDIMEEEKQEYLKQGYNVIMDIPLLFENELENTVDEVWVIYTSESIQMDRLMQRNNLSLEDAKARVYSQISIDKKSRMADHVIDNLGDKLELKQNLERLLKEEGYIEKPNYGEED
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIC_SALRU
Sequence: MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYTDSATAIDKSTFAASATTLGGTPAITGDLKFDDTTGKYYADVSGTTAKDGVYEVTVAADGKVTLTGTPTGPITAGFPSTATKDVKQTQQENADLTEAKAALTAAGVAAAGHRSVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADNGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
What are the official names of this protein?
Flagellin, Phase 1-R flagellin.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: SPNS1_MOUSE
Sequence: MAGSDTAPFLSQADDPDDGPAPGHPGLPGPMGNPKSGELEVPDCEGLQRITGLSRGHSTLIVVVLCYINLLNYMDRFTVAGVLTDIEQFFNIGDGSTGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPREHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDVAGDWHWALRVTPGLGVLAVLLLFLVVQEPPRGAVERHSGSPPLSPTSWWADLKALARNPSFVLSSLGFTSVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRRFNPRADPLVCAAGLLGSAPFLFLALACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRSWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAMFIEDDRRRAQLHVQGLLHESGPSDDRIVVPQRGRSTRVPVSSVLI
What is the function of this protein?
Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949).  Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids (PubMed:36161949).  Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin (PubMed:36161949).  Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively (PubMed:36161949).  Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine.  Essential player in lysosomal homeostasis (PubMed:36161949).  May be involved in necrotic or autophagic cell death (By similarity).
What are the official names of this protein?
Protein spinster homolog 1, MSpin1, Spns1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y850_VIBCH
Sequence: MSSEMIHVEVVYALPHEQRVLKLVVEQSATVEEIIRTSGILQMYPEIDLTVNKVGIFSRNVKLDARVRDKDRIEIYRPLLADPKEIRRKRAEQAKAAANQS
What are the official names of this protein?
UPF0125 protein VC_0850.
What is the protein family that this protein belongs to?
Belongs to the UPF0125 (RnfH) family.
Protein: UP07_DAUCA
Sequence: YGLAADNVLDAR
What are the official names of this protein?
Unknown protein 7.
Protein: RBFA_BORBZ
Sequence: MYKNIKKFKLESFIAQEIGNLIVSGGIKDPRIHSFLTVVKVEFSKDLINAKVFMGSIKEGASLDNAVKALNNAKGFIQSQIIKRIKVRSTPKLLFVKDDSLSKSFYVNKLIEGLNTTREN
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DER_VARPS
Sequence: MKPVVALVGRPNVGKSTLFNRLTQTRDAIVADFAGLTRDRHYGNGRLGKHEFIVIDTGGFEPDAGSGIYKEMAKQTRQAVAEADVVIFVVDAREGLSAQDHDIANELRRLGKPCVLAANKAEGMHDGTKLVDFYELGFGDVHGVSAAHGQGMRDLVELALAPLNLPDPDDEADEDDVNKPIKLAVAGRPNVGKSTLINTWLGEERLVAFDLPGTTRDAISVPFERNGQRFELIDTAGLRRKGKVFEAIEKFSVVKTLQAIESASVVLLLLDATQGVTDQDAHIAGYILESGRAVVIAINKWDAVDSYQREQIQRQIETRLPFLKFASLHFISAIKRQGLGPVWQAIAQAHKSATRKMSTPVLTRLLLEAVQFQSPKRAGMFRPKLRYAHQGGMNPPVIIIHGNSLEHVTEAYKRFLEGRFRKEFDLVGTPLRIQFKSSQNPFADKDD
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: ASB2_HUMAN
Sequence: MATQISTRGSQCTIGQEEYSLYSSLSEDELVQMAIEQSLADKTRGPTTAEATASACTNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
What is the function of this protein?
Targets filamins FLNA and FLNB for proteasomal degradation (PubMed:21737450, PubMed:22916308, PubMed:24044920, PubMed:24052262).  This leads to enhanced adhesion of hematopoietic cells to fibronectin (PubMed:21737450).  Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (By similarity).  Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (By similarity).  Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (PubMed:22916308).
What are the official names of this protein?
Ankyrin repeat and SOCS box protein 2, ASB-2.
What is the protein family that this protein belongs to?
Belongs to the ankyrin SOCS box (ASB) family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, stress fiber. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to the Z line in cardiomyocytes.
Protein: DGOD_ECOUT
Sequence: MKITKITTYRLPPRWMFLKIETDEGVVGWGEPVIEGRARTVEAAVHELSDYLIGQDPSRINDLWQVMYRAGFYRGGPILMSAIAGIDQALWDIKGKVLNAPVWQLMGGLVRDKIKAYSWVGGDRPADVIDGIKTLREIGFDTFKLNGCEELGLIDNSRAVDAAVNTVAQIREAFGNQIEFGLDFHGRVSAPMAKVLIKELEPYRPLFIEEPVLAEQAEYYPKLAAQTHIPLAAGERMFSRFDFKRVLEAGGISILQPDLSHAGGITECYKIAGMAEAYDVTLAPHCPLGPIALAACLHIDFVSYNAVLQEQSMGIHYNKGAELLDFVKNKEDFSMAGGFFKPLTKPGLGVEIDEAKVIEFSKNAPDWRNPLWRHEDNSVAEW
What is the function of this protein?
Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.
What are the official names of this protein?
D-galactonate dehydratase, GalD.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.