PharMolix/UniProtQA huggingface dataset:
Protein: PRX1_PENRO
Sequence: MANPLISNHIGKHGKYTQAFLEQNGPGDARPTALDILKDNDRIDNMKDKVFLLTGSSGGIGIETGRALAATGGKVYLGVRDLEKGKQALAEILEPGRVELLELDVGSMESVRTAAKTFLSKSTQLNVLVNNAGIMACPEAKTVDGFESQLAINYLGHFLLYKLLEQTLLSSSTPEFQSRVVNVSSAGHHMSSVVLDNINLEGEYEPWKAYGNAKTACIWMTNEIEHRYGSKGLHGLSLMPGGIATSLQRHVDPETLKEWGSSEFAQKYAKSSAQGAATTITAALGKEWEGKGGVYLEDCQEAGPVPEGGTLAVGVAPHAFDPEGEKKLWDLSLKMLNLSE
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699, PubMed:27921136).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:8440737, PubMed:15186158, PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699, PubMed:26274339).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase ORF6 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699, PubMed:27921136).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase ORF8 (PubMed:16345540, PubMed:24239699, PubMed:27921136).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:16345540, PubMed:24239699).  The cytochrome P450 monooxygenase ORF6 is probably also involved in this step (PubMed:27921136).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:16345540, PubMed:24239699).
What are the official names of this protein?
Short-chain dehydrogenase/reductase prx1, PR-toxin biosynthesis cluster protein 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: YL361_YEAST
Sequence: MAVSNNNNNNNSKERTQNIKEVEEKLGENPKITLKGGGKTKIMDFEQLRKPHCVRPSARFPVEDTAGGLLRTGGHRPQISDEEVSKRHHEQSHGQEDH
What are the official names of this protein?
Uncharacterized protein YLR361C-A.
Protein: SYFB_PSET1
Sequence: MKFSEKWLREWVNPAIDTQALSEQLSMAGLEVDGVTPAAAKFNGVLVGEVVECGQHPDADKLRVTKINVGGDELLDIVCGAPNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGDGIMELPSDAPVGTDLREYLGLDDNIIDVDLTPNRGDCLGIKGLAREVGVLNSIDVNVLQIPAVTATVDDKVSIELVNEDACPRYLGRVIKGINLDTATPLWMVEKLRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNSVKLNESTLVIADHNKALAIAGIFGGEQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAIERATALLLEIVGGEAGPVVEAVAADKLPKVTEVRLRRSRLDRVIGHHIEDEKVTDILTRLGFNVKVENDSWSADVPSYRFDVRIEEDLIEEVARVYGYNSIPNVAPTAKLKMTTHNEATIALSKFRNTLVARGYQEAITYSFVDPKAQAILHPESQPLVLPHPISIEMSAMRVSLMPGLLASLAYNQNRQQPRIRLFEHGLKFLSDENAENGVNQVPVIGGVITGLAHGEHWVEEKRNVDFYDVKGDVEALLAITNDMSRFEIKAEQSDGLHPGQSAVIYVAGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAIEKRNLPQVAGVSKFPSNRRDIAILVQESVNIGDILTAIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQSVDRTLEEKDINLVVDNVVATLAEQFNASLRD
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAMT_CLABR
Sequence: MDVRQVLHMKGGAGENSYAMNSFIQRQVISITKPITEAAITALYSGDTVTTRLAIADLGCSSGPNALFAVTELIKTVEELRKKMGRENSPEYQIFLNDLPGNDFNAIFRSLPIENDVDGVCFINGVPGSFYGRLFPRNTLHFIHSSYSLMWLSQVPIGIESNKGNIYMANTCPQSVLNAYYKQFQEDHALFLRCRAQEVVPGGRMVLTILGRRSEDRASTECCLIWQLLAMALNQMVSEGLIEEEKMDKFNIPQYTPSPTEVEAEILKEGSFLIDHIEASEIYWSSCTKDGDGGGSVEEEGYNVARCMRAVAEPLLLDHFGEAIIEDVFHRYKLLIIERMSKEKTKFINVIVSLIRKSD
What is the function of this protein?
Catalyzes the methylation of the free carboxyl end of the plant hormone salicylic acid (SA).  Converts SA to SA methyl ester (MSA).  The volatile compound MSA is hypothesized to act as an airborne signal that triggers defense responses in uninfected plants.  MSA is an important chemoattractant for moth pollinated flowering plants.
What are the official names of this protein?
Salicylate carboxymethyltransferase, S-adenosyl-L-methionine:salicylate acid carboxylmethyltransferase, CbSAMT, Salicylate O-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. SABATH family.
Protein: RPB1B_HUMAN
Sequence: MNAPPAFESFLLFEGEKITINKDTKVPKACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRTCLLPLRLLP
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs.  Pol II is the central component of the basal RNA polymerase II transcription machinery.  It is composed of mobile elements that move relative to each other.  RPB11 is part of the core element with the central large cleft (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase II subunit RPB11-b1, RNA polymerase II subunit B11-b1, RPB11b1, DNA-directed RNA polymerase II subunit J2.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
Protein: TMFO1_MESFL
Sequence: MQKEVNIIGAGLAGCEAAYLLANNGVKVNLFEVKSLMKNDIQKTNDLGELVCSNTLRSKSKKNAAGILKNEMKLLNSLVIKAALENEIPGDDALSVDRFGFSKYITDKIKNHKNINLIEQEVSEVDYTKVTIIASGPLTTDKLGKNIELMTGNEKLFFLDASAPIITKDSIDFNKVYWASRHNDGKDGQYICIPLNEEQFNAFVEELKNAETIKLKSFEKEIYFKGCQPIEQIAKTSKKVLLNGPLSPNNLIDENGNTPFAVVQLRQDDAIDSLYNFVGFQTNIKWPEQKRILQTLPGLENLNIVRFGVMHKNYYINSPKLLNRSLQVKRNKNIFFAGQITGVEGYIESASSGILTAINVLAYLNNIKIEQPSRKSMLGALNFYITNPKHDKLKPMKCNLGILDQQNKNAKSEFYSFDESEREIRRFIKGINNFAKIGENNE
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO 1, Folate-dependent tRNA (uracil-5-)-methyltransferase 1, Folate-dependent tRNA(M-5-U54)-methyltransferase 1.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACES_DANRE
Sequence: MKTSDILLLPTVLLTFLFHNCFAQAEPDLVVATRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKRAEPKKPWNNVFEAKEFSNACYQFVDTSYPGFPGIEMWNPNRVMSEDCLYLNVWVPPTPRPQNLTVMVWIYGGGFYSGSSSLDVYDGRYLAYTEKVVVVSMNYRVGAFGFLALNGSSDAPGNVGLYDQRLALQWVQENIHFFGGNPKQVTIFGESAGAASVGMHVLSPDSRPLFTRAILQSGVPNTPWATVTFDEARRRTTKLGKLVGCTWGNDTELIDCLRNKHPQELIDQEWQVLPWSSLFRFSFVPVVDGVFFPDTPDAMISSGNFKYTQILLGVNQDEGSYFLLYGAPGFSKDNESLISREDFLESVKMGVPHANDIGLEAVILQYTDWMDENNGQKNRDAMDDIVGDQNVICPLQHFAKSYAQYAALHAQSSAAAPGTLGWGNSGPTGYNSGNSHGAVYLYLFDHRASNLAWPEWMGVIHGYEIEFVFGLPLEKRLNYTAEEEKLSRRIMRYWANFARTGNPNVNTDGTMDSRRRWPQFSANEQKHVGLNTEPMKVHKGLRTQFCALWNRFLPRLLNITDNIDDVERQWKVEFHRWSSYMMHWKSQFDHYSKQERCTDL
What is the function of this protein?
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
What are the official names of this protein?
Acetylcholinesterase, AChE.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Synapse. Secreted. Cell membrane; Peripheral membrane protein.
Protein: NAC5_ARATH
Sequence: MANPVGFRFRPTDGEIVDIYLRPKNLESNTSHVDEVISTVDICSFDPWDLPSHSRMKTRDQVWYFFGRKENKYGKGDRQIRKTKSGFWKKTGVTMDIMRKTGDREKIGEKRVLVFKNHGGSKSDWAMHEYHATFSSPNQIMTYTLCKVKFKGERREFSVATGSGIKHTHSLIPPTNNSGVLSVETEGSLFHSQESQNPSQFSGFLDVDALDRDFCNILSDDFKGFFNDDDEQSKIVSMQDDRNNHTPQKPLTGVFSDHSTDGSDSDPISATTISIQTLSTCPSFGSSNPLYQITDLQESPNSIKLVSLAQEVSKTPGTGIDNDAQGTEIGEHKLGQETIKNKRAGFFHRMIQKFVKKIHLRT
What are the official names of this protein?
NAC domain-containing protein 5, ANAC005.
What are the subcellular locations of this protein?
Nucleus.
Protein: DAPF_SALSV
Sequence: MQFSKMHGLGNDFMVVDAVTQNVFFSPELIRRLSDRHLGVGFDQLLVVEPPYDPELDFHYRIFNADGSEVSQCGNGARCFARFVRLKGLTNKRDIRVSTANGRMVLSVTEDELVRVNMGEPNFEPAQVPFRANKAEKTYIMRAAEQTILCGVVSMGNPHCVIQVDNVDTAAVETLGPVLESHERFPERANIGFMQVVRREHIRLRVYERGAGETRACGSGACAAVAVGIQQGLLAEEVRVELPGGRLDIAWKGPGHPLYMTGPAAHIYDGFIHL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RB11A_CHICK
Sequence: MGNRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKMQCCQNI
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  The small Rab GTPase RAB11A regulates endocytic recycling (By similarity).
What are the official names of this protein?
Ras-related protein Rab-11A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane.
Protein: FER3_CYACA
Sequence: ASYKIHLVNKDQGIDETIECPDDQYILDAAEEQGLDLPYSCRAGACSTCAGKLLEGEVDQSDQSFLDDDQVKAGFVLTCVAYPTSNATILTHQEESLY
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MNME_RHOPA
Sequence: MHPSDQTIFALATGPLPSAIAIVRVSGSRAGEVLTALTGSLPPPRRAVRCDLRSRDGDLIDDGVALWFPTPASATGEDVAELHIHGSRAVAAALIKTLSAFEGVRPAEPGEFTRRGFENGKLDLTEAEGLDDLIHADTDAQRRQALRQLGGVLGDRARRWRDQIIEALALVEAGIDFSDEGDVADELMGPARAKIAELSAEIAEVLAEQGRGEKLRDGMVVAIAGPPNVGKSTLINRLARREVAIVSPHAGTTRDVIEIQLDLDGYPVTVIDTAGLRDSDDPVEQEGVRRARSRAAAADLVLWLSTATDASDPDVKGPEVWRVRNKIDLATGEVAESGPSQPVFRISAATGEGFADLLRELTRFAAQYFGSAEAGLITRDRHRRLLADAAASLTRSLVPGLAEEIVAEELRASAHSLGRLLGRVDVEDVLGEIFGRFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPP_NITEC
Sequence: MSLNTLANIVPEKDTSLEKDHPLREDIRLLGRMLGDTIRELEGEPMFDLVETIRQTAVRFRREQDEEAGKELDTILNHLSHKETTAVVRAFSYFSLLSNIAEDLHHNRRRRAHLRAGSPPQDGSVTLALERVVAKGINTQQLENFFAEALISPVLTAHPTEVQRRSILDYQLKIQRLLKERDRTQLTPNELRHNEEDLRSAIQTLWQTRVLRSVRLTVQDEIENGLIYYHYTFLKQIPYIYAKIEDILERHMDKAAPCIASFLRIGSWIGGDRDGNPFVTHQIMLHAAERHSALILDYYIEEVEKIGQAMSLTERLIKVTSELEGLASTAPGLPASRIDEPYRRVFLGMHTRLIATSRYLSPHVGRQYQENTAEPYADSAEFVHDLDIVIRSLKQHQSNKLAQGAIRDLRRAVDVFGFHLASLDMRQHSKIHEQVVSELYEKNAQDNRNYPDLTRAERAEWLLAELKRSHPLVSSLSDYSDITQGELRILRMAAEIQRRFGHVALPNYIISMATGVIHILEAALLLKEAGLLQFGEAARSTVNIIPLFETIDDLRGCANVMEELFSLPEYRKMLRSRSNLQEVMLGYSDSNKDGGFVTSNWEIHKAEIELTKVFNRHGVRLRLFHGRGGTVGRGGGPSYQGILAQPPGSVNGQIRLTEQGEVIASKYTDPEIGRRNLETLVAATIESTLLDRDAIHCHTPQCYQIMEELSASAYAAYRDLVYKTPNFTQFFQESTPIREIAGLHIGSRPTSRKPSNKIEDLRTIPWVFSWSLNRTMIPGWYGFGTAVENFVQQAGNTQDVLIQMQKMYRTWPFFQTLLSNMDMVLAKSDLGIASRYAELVTDSELRQYVFTAIRTEWELCVKWLFAITGHTELLQDNPTLARSIRIRTPYIDPMNHLQVELLRRYRSGDDDDAIRRAIHLTINGVATGLRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: SECM_ECO7I
Sequence: MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYHIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLS
What is the function of this protein?
Regulates secA expression by translational coupling of the secM secA operon.  Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
What are the official names of this protein?
Secretion monitor.
What is the protein family that this protein belongs to?
Belongs to the SecM family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Periplasm. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease.
Protein: PIMT_VIBPA
Sequence: MSNPHADRLIAFLISSGIKDQRVLDAMHCLPRESFVSQAMMHQAYDNNALPIGQGQTISQPYIVARMTELLELQRASNVLEIGTGSGYQTAVLAQIVDHVYSVERIKSLQWEAKRRLKQLDIYNVSTKHGDGWLGWETKGPFDAIIVTAAAEVIPQALLSQLKDGGKMVIPVGDAEQQLLRIERKGDEYLSTVVEMVRFVPLVAGDLA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: INSI1_CHICK
Sequence: MPRLESGAWSCSCAARARHAARPGEAAPKADAMQSPSPSAGRAEREASGGSATTWRQHLVQRSVVLFVVGAFMALVLNLLQIQRNVTLFPDEVIATLFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCIAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFVATLITQFLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGIPEKPHND
What is the function of this protein?
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR.  Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs).  Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum.  In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBPs to the Golgi.  Sterol deprivation reduces oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs.  Also regulates cholesterol synthesis by regulating degradation of HMGCR.
What are the official names of this protein?
Insulin-induced gene 1 protein, INSIG-1.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RLMD_XANAC
Sequence: MARTRNRLDRTPFQTAVTDLSHDGRGVARRDGEGGKVTFISGALPGELVRAEPTARSRHFDEAKTVGVLEASPQRVTPRCPHFGVCAGCVLQHLEESQQIVAKQRVLMDNLERIGHVTPQAVLPALTGDNWGYRRKGRFSVRRVEKKDKTLVGFRELDPRFVADLSVCYTVIPQIGEKIPLLAALIEGMDGKRDIPQIEFIAGDDAVALTIRHMQPLSERDRQAWITFAQEHGFAIFLQPGGVDSVQPLWPQEVPLSFRLPQWDVELAFRPLDFIQVNASLNQKMIAHAVALLEAKPDDRVLDLFCGLGNFTLPLARVVREVVGVEGDAGLVARAKENAQRNGLDNAQFYAADLTQDQRSAPWMRQGFDKLLLDPPRSGALEVLQQLPLKTFQRIVYVSCHPGSLARDAGYLVNEQGFTLVSAGAMDMFPHTAHVESIAVFERR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD, 23S rRNA(m5U1939)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.
Protein: IF1_STRP1
Sequence: MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPYDLTRGRITYRFK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EIBD_ECOLX
Sequence: MSKKFTMTLLSSSLAGLLVMSGGVSAQNGTYSVLQDDSQKSGPVKYGSTYEVVKTVDNGNFRYEVKEKKNDKRTLFKFDSEGNVTVKGKGITHTLHDPALKDFARTAEGKKNEQNGNTPPHKLTDSAVRGVYNKVYGLEKTEITGFSVEDGENGKVSLGSDAKASGEFSVAVGNGARATEKASTAVGSWAAADGKQSTALGVGTYAYANASTALGSVAFVDNTATYGTAAGNRAKVDKDATEGTALGAKATVTNKNSVALGANSVTTRDNEVYIGYKTGTESDKTYGTRVLGGLSDGTRNSDAATVGQLNRKVGGVYDDVKARITVESEKQKKYTDQKTSEVNEKVEARTTVGVDSDGKLTRAEGATKTIAVNDGLVALSGRTDRIDYAVGAIDGRVTRNTQSIEKNSKAIAANTRTLQQHSARLDSQQRQINENHKEMKRAAAQSAALTGLFQPYSVGKFNATAAVGGYSDQQALAVGVGYRFNEQTAAKAGVAFSDGDASWNVGVNFEF
What is the function of this protein?
Binds (in a non-immune fashion) to the Fc portion of human IgA and IgG; binding occurs on the cell surface.  Confers the ability to survive exposure to human serum exposure (PubMed:10722621).  Binds to the Fc portion of human IgG, IgA and to whole mouse antibodies also via Fc (PubMed:19303642).  Upon overexpression cells acquire an extra cell surface layer that forms a zipper-like contact between cells; cells autoagglutinate and form biofilm more readily, suggesting it may play a role in defense against a host (PubMed:21742268).
What are the official names of this protein?
Immunoglobulin-binding protein EibD, Trimeric autotransporter adhesin EibD, TAA EibD, Type 5 secretion system autotransporter EibD.
What is the protein family that this protein belongs to?
Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family. Eib subfamily.
What are the subcellular locations of this protein?
Cell surface. Cell outer membrane; Multi-pass membrane protein. Note=The C-terminal translocator domain is localized in the outer membrane and the passenger domain is at the cell surface.
Protein: CCR1_ORYSJ
Sequence: MSSNFEANNNNNGEKQLVCVTGAGGFIGSWVVKELLIRGYHVRGTARDPADSKNAHLLELEGADERLSLCRADVLDAASLRAAFSGCHGVFHVASPVSNDPDLVPVAVEGTRNVINAAADMGVRRVVFTSSYGAVHMNPNRSPDAVLDETCWSDYEFCKQTDNLYCCAKMMAEMTATEEAAKRGLELAVVVPSMTMGPMLQQTLNFSTNHVARYLMGTKKSYPNAVAAYVDVRDVARAHVLVYERPEARGRYLCIGTVLHRAELLRMLRELFPRYPATAKCEDDGKPMAKPYKFSNQRLKDLGLEFTPLRKSLNEAVLCMQQKGHLPLIYPVPKRAYL
What is the function of this protein?
Involved in the latter stages of lignin biosynthesis.  Catalyzes one of the last steps of monolignol biosynthesis, the conversion of cinnamoyl-CoAs into their corresponding cinnamaldehydes.  Probably involved in the formation of lignin in defense responses.
What are the official names of this protein?
Cinnamoyl-CoA reductase 1, OsCCR1.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDRD7_MOUSE
Sequence: MLEADLVSKMLRAVLQSHKNGIVLPRLQGEYRSLTGDWIPFKQLGYPTLEAYLRSVPAVVRIEASRSGEIVCYAVACTETARIAQLVARQRTSKRKIGRQINCQMRVKKAMPFFLEGKPKATLRQPGFASDYSISRKPNSALLRDRGSALGVKADVDMPPYPDTPVQRHASMSANSRFSPKSSLPASFQTHISRACPTEVNDNLNQTVEKPNITPPASYTNKMDEVQNRIKEILDKHNNGIWISKLPHFYKEFYKEDLNQGVLQQFEHWPHICTVEKPCGGGQDSLLYPARREQPLKSDQDPEKELPPPPPAPKQEVPSQGSPAVMPDVKEKVAELLGKYSSGLWASALPKAFEDMYKVKFPEDALKNLASLSDVCTINYISGNTQKAILYAKLPLPTDKILKDEGQAQGDFDIKSMIEQEYLQIEKNMAESADEFLEDITVPPLVIPTEASPSVLVVELSNTNDVVIRYVGKDYSAAQELMEDEMKEFYSKNPRVTPIQTVHVGQLLAVNAEEDAWLRAQIISTDENKIKVCYVDYGFCENIEKSKAYRLNPRFCSLSFQATKCKLAGLEVLNDDPDLVKAVESLTCGKIFAVEILDKSDVPLVVLYDTSGEDDININATCLKAICDRSLQVHLQVDAMYTNVKVTNICSDGTLYCQVPCKGLNKLNDLLHKTEDYFHCKHMTSEYFISLPFCGKICLFHCKGKWLRVEITNVHSSRALDVQFLDSGNSTSVKVSELREIPPRFLQEMLAIPPQAIKCCLADLPQSIGMWTPDAVLWLRDSVLNCSDCSIKVTKMDETKGVAYVYLFTPNNFPDPHRSINRQITNADLWKHQKDVFLSAVSTAASSPGNRNGGTPAPGSPAESLRKSHPEVIKKSVLDHTSSFSLEELPPPVHLSRSGEHMDVYVPVACHPGHFVIQPWQEIHKLEVLMEEMILYYSVSEERHIAVERDQVYAAKVENKWYRVLLKGILTNGLVSVYELDYGKHELVNIRKVQPLVDVFRKLPFQAVTAQLAGVKCSQWSEEASMVFRNHVEKKALVALVQTVVEHTNPWDRKVVLYLVDTSLPDTDTWIHDFMSQYLLELSKVN
What is the function of this protein?
Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation.  Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens.  Also required during spermatogenesis.
What are the official names of this protein?
Tudor domain-containing protein 7, PCTAIRE2-binding protein, Tudor repeat associator with PCTAIRE-2, Trap.
What is the protein family that this protein belongs to?
Belongs to the TDRD7 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids.
Protein: ARGR_ECOUT
Sequence: MRSSAKQEELVKAFKALLKEEKFSSQGEIVAALQEQGFDNINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTSSPLKNLVLDIDYNDAVVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFTTPANGFTVKELYEAILELFDQEL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.