PharMolix/UniProtQA huggingface dataset:
Protein: CTIP_RAT
Sequence: MSISGSSCGSPNSTDISSDFKELWTKLKEYHDKEVQGLQIKVTKLKKERILDAQRLEEFFTKNQQLRDQQKVLQETIKILEDRLRAGLCDRCAVTEEHMHKKQQEFENIRQQNLRLITELMNEKSALQEENKKLSEQLQQKMESGQQDQVAELECEENIIPDSPITSFSFSGINRLRRKENLHVRYVEQTHTKLEHSACTSELRKFSKGSTPAPVNSEEHEILVADTCDQSHSPLSKICGTSSYPADKLSSNLDAVVAETLGLDGQEESEPQGPVSPLGNELYHCLKEDHKKQPFMESAIRNEDNVRFSDSASKAPPRELTTRGSSPVFGPTSTVKTHLGLKTSFSPSLLDSGKKNLLSTAPFSSISVSRSEKVRSKSEDNALFTQQSAGSEVKVISQSFPSKQILTSKNVSDSVDEQGGADHMKDAVSDKHLVPLKSLGGKASKRKRTEEEGEHAVHCPQTCFDKENALPFPMENQFPVNGDHVMDKPLDLSDRFAANQRQEKNHGDETCKHKLKQVTIYEALKPVPKGSSSGRKALSGACTLAQDSAETYCLQQRTLQCSSKFSPDHNTQLQIKEENPVFKTPPRSQESLETENLFGDVKGIGSLVPIKVKGRSAHGGCELASVLQLNPCRVAKTKSLPSNHDMSFENIQWSVDPGADLSQYKMDVTVIDTKDSSHSRLGGETVDMDCTLVSETMLLKMKKQEQREKSPNGDIKMNDSLEDMFDRTTHEEYESCLADNFSQVPDEEELSDTTKKPNIHGDKQDGIKQKAFVEPYFKDKERETSIQNFPHIEVVRKKEERRKLLGHTCKECEIYYADLPAEEREKKLASCSRHRFRYIPTNTPENFWEVGFPSTQTCLERGYIKEDLDPCPRPKRRQPYNAVFSPKGKEQRT
What is the function of this protein?
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway.  HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse.  Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ).  Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA.  Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (By similarity).  During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity).
What are the official names of this protein?
DNA endonuclease RBBP8, CtBP-interacting protein, CtIP, Retinoblastoma-binding protein 8, RBBP-8, Retinoblastoma-interacting protein and myosin-like, RIM, Sporulation in the absence of SPO11 protein 2 homolog, SAE2.
What is the protein family that this protein belongs to?
Belongs to the COM1/SAE2/CtIP family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with sites of DNA damage in S/G2 phase. Ubiquitinated RBBP8 binds to chromatin following DNA damage.
Protein: RPOB_PHOPR
Sequence: MVYSYTEKKRIRKDFGKRPRVLDAPYLLSIQLDSFKKFIEQDPEGHYGLEAAFRSVFPIQSYNGNSELQYVSYRLGEPVFDVKECQIRGVTYSAPLRVKLRLVMYDKDAPAGTVKDIKEQEVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARVIPYRGSWLDFEFDPKDNVFVRIDRRRKLAASVILRALDYTTEQILDMFFDKVSFEVQGKSLVMELVPERLRGETASFDIEANGKVYVEQGRRITARHIRQLGKDGVDQIEVPVEYIVGKISSRDYVNEETGELIAAANQELNLEILALLSQAGHKSIEVLFTNDLDYGPYMSETLRVDSTTDRLSALVEIYRMMRPGEPPTREAAEQLFNSLFFSEDRYDLSAVGRMKFNSSLLREETTGSGILDHSDIIEVMKKLIEIRNGRGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDAIMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHATHYGRLCPIETPEGPNIGLINSLSVYARCNSYGFLETPYRKVVDSKVTDQIDYLSAIEEGQYVIAQANAALETDGSFSDELITARQKGDSGLHPRDHVQYMDVATNQVVSVAASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGIERSVAVDSGVTAVAKRGGQVQSVDASRIVVKVNEDELVPGEAGIDIYNLTKYTRSNQNTCINQRPTVMPGEPVARGDVLADGPSTDLGELALGQNIRIAFMPWNGYNFEDSILVSERVVQQDRLTTIHIQELSCVARDTKLGSEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNSVSGTIIDVQVFTRDGVEKDKRALEIEEMQLKEAKKDITEEFQILEGGLLARVRTLLLSIGYSEEKIASMDRERLFALTLDDESLQNQLEQLAEQYDELKAEFDKKFETKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKICPVEDMPYDEKGQTVEIVLNPLGVPSRMNIGQILETHMGLAAKGIGDKLNEMLKQQQELHKFRNFLQKVYDLGDTRQDVDIAALSDDQVHTLVQNLRDGLPIATPVFDGAPESSIKELLKLGDLPESGQLKMFDGRTGDMFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAFTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEPGMPESFNVLLKEIRSLGINIELEDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: TM86A_BOVIN
Sequence: MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSALIKCLPIFCLWLFLLAHGLGFLLTHPSATRIFVGLVFSAIGDAFLIWQDQGYFVHGMLMFAVTHMLYASAFGMRPLGLRTGLLMVILSGLCYAFLYPNLTGAFTYVVGVYVAIIGFMGWRAMAGLQLVGAAWRWTELAAGTGALLFIVSDLTIALDKFCFPVPYSRALIMSTYYAAQMLIALSAVESREPVEDYRLSKAK
What are the official names of this protein?
Lysoplasmalogenase-like protein TMEM86A, Transmembrane protein 86A.
What is the protein family that this protein belongs to?
Belongs to the TMEM86 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SYP_STRS2
Sequence: MKQSKMIIPTLREMPSDASVISHALMLRAGYVRQISAGIYSYLPLANRVIEKAKNIMREEFDKIDAIEFLAPALLSADIWRESGRYETYGDDLYKLKNREGSDFILGPTHEETVTLLARDAVQSYKQLPLNIYQIQPKYRDEKRPRNGLLRGREFIMKDGYSFHASYESLDQTYDDYKAAYEAIFTRAGLEFKAIIGDGGAMGGKDSQEFMAITPDRTDLDRWVVLDKSVASFEEIPEDVLEAFKAELLAWSVSGEDTIAYSSESGYAANLEMATSEYKPSTAVVVEEDLVKVATPDAKTIDEVAAFLNVAEEQTIKTMLFMADGEPVVALLVGNDQVNDVKLKNHLAADFFDVASPADAEKVFGAGFGSLGPVGLPENIKIIADRKVQDVKNAVVGANEDGFHYTGANAGRDFQVTEYVDIREVKEGEPSPDGHGVLNFARGIEIGHIFKLGTRYSDSMNANILDENGRSMPIIMGCYGIGVSRLLSAVLEQHARLFVNKTPKGEYRYAWGINFPKELAPFDVHLIPVNVKDEAAMELTQSIEASLVGAGYEVLTDDRNERVGVKFSDSDLIGLPIRVTVGKKAADGIVEVKIKGTGDTVEVHVDQLLETLQILTKENE
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_MYCPU
Sequence: MNEKNSDEINYDFKVDSNLNHTTSHLLAAAIVQLYPNVKLGFGPAIEEGFYYDFEFENPLSKLELLKIEKLMKKLASMNLKMVKVDGSNYDFTNKPYKKELYDELKQKGQEITFYSLVDTNGKEIFTDLCAGGHVESTSKINNFKLLSLAGAYWRGNSNNIQLTRIYGSSFYKKDELENYLKVIEDRKERDHRKIGKNLGIFTFSSLSGLGFPIWLKKGMLIKRAIEKEILYLDRKYGFEEVLSPHFGEESLYIKSGHLAHYQETMFKSLEVENEKLIPRPMTCPHHIIIYDAFPRSYRELPLRLSEQSRLYRYEKSGALTGLERVRTMDLTEGHIFIRQDQIKDEVLNMINLIQETLKIFKIKIDHVALSLRDNDKEKFFDDDQMWDQAESALKEILDQNKIDYIVEKGEAAFYGPKIDFQVKTVLNNIITMSTIQLDFLLPRKFNISYIAPDGSKQTPLMIHRGLIGTYERFVSILLEQTKGNFPFWLSPSQVIVLPIAKEFKEYAFEIYSKIFKQNFNVEIDNRDETINKKIREAQINKYKYQIIIGKQEMENKTIAIREYGKVQTITMDLESFIEKIKSQRDSKE
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_BORPA
Sequence: MQARANARSARRRAREFALQGVYAWLLRGGEGTQDAGEIDAHLRDAEDFSEADAQWFKTLLHGVLREAPVLRERFLPYIDRPLAELSPVEHGILLIGSFELMHHVEVPYKVAINEAVELAKSFGGTDGFKFVNGVLDKLAADVRTAEVQAAPRR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: SYM_SHEFN
Sequence: MTKSQRKILVTSALPYANGPIHLGHMLEYIQTDIWSRFQKLRGHECHYICADDAHGTPIMLKAQQMGITPEEMIAQVQKEHQQDFADFNIQFDNFHSTHSEENRILASDIYLKLRDGGYIKTKTISQLYDPEKLMFLPDRFVKGTCPKCKSEDQYGDNCDNCGATYSTTDLINPKSAVSGATPIMKDTEHFFFDLPAFEGMLKEWIQSGSLQQEMANKLNEWFEQGLKQWDISRDAPYFGFEIPDAPGKFFYVWLDAPIGYMGSFKNLCDKRDDLNFDDFWSLDSTAEVYHFIGKDIVYFHSLFWPAMLEGAGIRKPTSVYAHGYVTVNGSKMSKSKGTFIKARTYLDNLDPEYLRYYYAAKLNSRIDDLDLNLEDFAQRVNSDLVGKLVNLASRTAGFISKRFDGKLAKVTDSSLTDIFLAKSEVIAELYETREFGKAMREIMALADIANAYVADAAPWQLVKQDDKQDEAHQVCSNALNLFRILVTYLKPVLPKLAENVEGFLQLTLTWDNLGQDLAGHEIATFKALMQRIEPKSIEAIIDASKENLQATNTDAPKTEAPTQAVNQLELDPISPEISFEDFAKIDLRIARISKAEHIEKANKLLRLELDLGGDTKQVFAGIKSAYAPEDLVGKLTVMVANLAPRTMKFGDSEGMVLAAGPGGKDLFILEPHEGALPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AIS_SHIFL
Sequence: MLAFCRSSLKSKKYFIILLALAAIAGLGTHAAWSSNGLPRIDNKTLARLAQQHPVVVLFRHAERCDRSTNQCLSDKTGITVKGTQDARELGNAFSADISDFDLYSSNTVRTIQSATWFSAGKKLTVDKRLLQCGNEIYSAIKDLQSKAPDKNIVIFTHNHCLTYIAKNKRDAIFKPDYLDGLVMHVEKGKVYLDGEFVNH
What is the function of this protein?
Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.
What are the official names of this protein?
Lipopolysaccharide core heptose(II)-phosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. Ais subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: PB2_I66A1
Sequence: MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIMEMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKIAPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAMVSADPLASLLEMCHSTQIGGIRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKREEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVGGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIETIDNVMGMIGILPDMTPSTEMSLRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDLRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWEAVKIQWSQDPTMLYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVIGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYSKATKRLTVLGKDAGALTEDPDEGTAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RBSD_ENT38
Sequence: MKKGTVLNSEISSVISRLGHTDTLVVCDAGLPVPHSTTRIDMALTQGVPSFMQVLDVVTAEMQVETAILATEIKQHNPQLHETLLGHIEQLQQHQGNTIEIRYTTHEQFKQQTADSQAVIRSGECSPYANIILCAGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VA5_VESMA
Sequence: NNYCKIKCRSGIHTLCKFGISTKPNCGKNVVKASGLTKAEKLEILKQHNEFRQKVARGLETRGKPGPQPPAKSMNTLVWNDELAQIAQVWAGQCDYGHDVCRNTAKYSVGQNIAENGSTAASFASVSNMVQMWADEVKNYQYGSTKNKLIEVGHYTQMVWAKTKEIGCGSIKYIENGWHRHYLVCNYGPAGNIGNEPIYERK
What are the official names of this protein?
Venom allergen 5, Antigen 5, Ag5, Cysteine-rich venom protein, CRVP.
What is the protein family that this protein belongs to?
Belongs to the CRISP family. Venom allergen 5-like subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVD_ACIBY
Sequence: MPDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAAEIQAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGDEKAIDLVDAMVVAADDSYTDEEVAEFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGQLIVELAKRYYEQNDASILPRSIATKAAFKNAMTLDIAMGGSTNTVLHLLAAANEAEVDFTMDDIDELSRRVPVLSKVAPAKQDVHMEDVHRAGGIMAILGELDRANLLDVSVPTVHEKTLKDALDKWDIIRTEDPDVYEFYRSSPGGVPTQVAFSQNRYYSTLDGDREKGVIRNAEHAFSKDGGLAVLYGNIALDGCIVKTAGVDESILKFTGSARVFESQDAAVEAILGNEIKAGDVVIIRYEGPRGGPGMQEMLYPTSYLKSKGLGKDCALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEDGDTIEIDIPNRTIHLNIDDATLAHRRTVQEAKGWHPKEERKRKVSKALKVYAMHTTSAAKGAVRVL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: TPIS_PASMU
Sequence: MARRPLVMGNWKLNGSKAFTKALIEDLKTELAGVEGCDVAIAPPVMYLAEAEAALKCSCSCGGKAIALGAQNVDVNVQGAFTGDISTEMLKDFGAKYIIIGHSERRTYHKESDEFIAKKFAALKQAGLVPVLCIGESEAENEAGKTEEVCARQIDAVLNTLGAEAFNGAVIAYEPIWAIGTGKSATPAQAQAVHAFIRGHIAKKDNAVAEQVIIQYGGSVNDANAAELFTQPDIDGALVGGASLKAPAFAVIVKAAAKAKN
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_THIDA
Sequence: MSVDIAVVDYGMGNLRSVSKAIEHVAPSATVVVTSSPDVIAEAGRVVFPGQGAARDCMREIDARGLREAIATAARSKPFLGICMGMQVLFEHSEEGDTACLGILPGNVQRFPHEAMHDDRGNKLKVPHMGWNNVHQGAPHPLWSGIEDGERFYFVHSYFVQPTTPDLIAGFSHYPFPFTCAVASGNIFAVQFHPEKSQNAGLTLLGNFVTWNPGEHASACDLSGASCA
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCR1B_CHICK
Sequence: MNGTVIPGTPIAVDFWSVRRAGGARLFFLSHMHSDHTVGLSSTWSRPLYCSPLTARLLHHRLKVPTRWIRPLEVGQSHAVGEEVTVTLLDANHCPGSVMFLFEGAFGTILYTGDFRYSPAMQREPALSGRRIDRLYLDNTNCRPHGALPSRSRAALQAAQLIRRHPQHRVVIGVYSLGKEELLVDLALEFGTWVVVSPSRLEQMRLLELPEVFTTEEGAGRIHAVDVAEIRWDTLVSWNVLHPTIAILPTGRPVKVTHPQIHLIPYSDHSSFSELCEFVKWLKPCSVIPIVKGDMCYASFQKYLSPDHQALPGLGIPKPLQVSVQWQSKTKKQKPVCLVKRAAQHSVPKGVVYEPLEEYIEQSDGLGGVTAPQQNSHESAFCSLEDGICFYDCKEEELSGEQPGGAMAAGTAGQSLVSDEDFPSELPKQYLLTPLNALKQSSFCKALKNLFIRWEPS
What is the function of this protein?
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase.  Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse.  Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways (By similarity).  May be required for DNA interstrand cross-link repair (PubMed:15572677).  Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity).  Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity).
What are the official names of this protein?
5' exonuclease Apollo, Beta-lactamase MBLAC2, DNA cross-link repair 1B protein, SNM1 homolog B.
What is the protein family that this protein belongs to?
Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
What are the subcellular locations of this protein?
Chromosome, telomere. Nucleus.
Protein: SSRP_METPB
Sequence: MAPKTEPGRRVVADNRSARFHYAIEDTFEAGIALTGTEVKSLRGGKATIGESYAGPSGNDLMLFNAYIPEYLEANRFNHDTKRPRRLLLHRRQINKLIGATQRQGYTVIPLKIYFNDKGRAKVELGLGKGKQLHDKRESVKQRDWQRDKARLMRDKG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ZMY10_XENLA
Sequence: MVQSLQTFSVRDIASGGWFKQHEYIEKLNMQAILNASAGQEEMIKDLLVTHGKIPTLIHELISVEIWKLKVFHVLCQLQDFQPKSTFPLYMVIHHEATIINLLETIFFHKEVCESAEDLTLDLIDYCYRKLTLLASQSSDRRTLSQNRLLPHTANEASSLEELKQQAEALEFDIALKCLSVTRYISDHIDSLPLSVMNRLLNTHNLPCLLVELLHQSPWTQSEKGQLQKYESGRWYPVPAEDQLKMTKLDGQAWIALYNLLLRPECQQKYNINSFTKGQLLKLRSFLTEVLLDQLPNLVDLQRFLSHLSVSEPTPPKKELILEQVPEVWDSIINENSGKWKAIAKYQVKQAFSPSEEDLRSQAKRWAQTYNMDVMEALVPEKPKCGSCGSEASKRCSRCQSEWYCKRECQVKHWQKHKKACDMVSEAMKNMQEEIQKEA
What is the function of this protein?
Plays a role in axonemal structure organization and motility.  Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity).  May act by indirectly regulating transcription of dynein proteins (By similarity).
What are the official names of this protein?
Zinc finger MYND domain-containing protein 10.
What is the protein family that this protein belongs to?
Belongs to the ZMYND10 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Apical cell membrane. Dynein axonemal particle. Note=Localizes both to the basal body and the striated rootlet, an appendage that projects away from the basal body into the cytoplasm.
Protein: TBB_PLAF7
Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGTYCGDSDLQLERVDVFYNEATGGRYVPRAILMDLEPGTMDSVRAGPFGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDAVLDVVRKEAEGCDCLQGFQITHSLGGGTGSGMGTLLISKIREEYPDRIMETFSVFPSPKVSDTVVEPYNATLSVHQLVENADEVQVIDNEALYDICFRTLKLTTPTYGDLNHLVSAAMSGVTCSLRFPGQLNSDLRKLAVNLIPFPRLHFFMIGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMCASDPRHGRYLTACAMFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPHNTKSSVCDIPPKGLKMAVTFVGNSTAIQEMFKRVSDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEEGDVEA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:33633135).  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Localizes to the parasite surface in subpellicular regions in trophozoites and schizonts (PubMed:33633135). In merozoites, localize to the apical end of the parasite (PubMed:33633135).
Protein: HSL57_DICDI
Sequence: MTILSTITSISRPNKISKSFVSSNGGSSISMGSNSVACYNACGGGSSYSYSSSYSGSGLDYSYKANYSSSTGNNSYVVIASSTCNCN
What are the official names of this protein?
HssA/B-like protein 57.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: E13H_TOBAC
Sequence: MAHLIVTLLLLSVLTLATLDFTGAQAGVCYGRQGNGLPSPADVVSLCNRNNIRRMRIYDPDQPTLEALRGSNIELMLGVPNPDLENVAASQANADTWVQNNVRNYGNVKFRYIAVGNEVSPLNENSKYVPVLLNAMRNIQTAISGAGLGNQIKVSTAIETGLTTDTSPPSNGRFKDDVRQFIEPIINFLVTNRAPLLVNLYPYFAIANNADIKLEYALFTSSEVVVNDNGRGYRNLFDAILDATYSALEKASGSSLEIVVSESGWPSAGAGQLTSIDNARTYNNNLISHVKGGSPKRPSGPIETYVFALFDEDQKDPEIEKHFGLFSANMQPKYQISFN
What is the function of this protein?
Implicated in the defense of plants against pathogens.
What are the official names of this protein?
Glucan endo-1,3-beta-glucosidase, acidic isoform PR-Q', (1->3)-beta-glucan endohydrolase, (1->3)-beta-glucanase, Beta-1,3-endoglucanase, PR-35.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast.
Protein: VE8E2_HPV65
Sequence: MKLKILLHSSTNTPSFDFEEQQLPGPSTPTYTELTQASPCGRGKSRESQPTSTTSPETSGLRVRRGRRQRKSGPGPGETPSKRRRGGGRGGGETRLESAPSPGEVGIRHRTVERQGLSRLGQLQAEARDPPMILLKGTANSLKCWRYRKQNSSNCGFLFMSTVWNWVGDVSENHSRMLIAFKSPGQRDSFVKHNLFPKLCTYTYGSLNSL
What is the function of this protein?
Plays a role in limiting the replication of viral DNA in keratinocytes.  Recruits the host NCoR/SMRT complex to viral replication foci to mediate repression of both viral replication and transcription.
What are the official names of this protein?
Protein E8^E2C.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E8^E2C protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: GLCU_BACSU
Sequence: MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIVIYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLFGVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVSTLGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAGGNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAAAVFLGIAKTNS
What is the function of this protein?
Involved in the uptake of glucose.
What are the official names of this protein?
Glucose uptake protein GlcU.
What is the protein family that this protein belongs to?
Belongs to the GRP transporter (TC 2.A.7.5) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MOKB_ECOLI
Sequence: MNLAIQILASYPPSGKEKGYEAQPSGGVSAHYLHYDSDIHTPDPTNALRTAVPGR
What is the function of this protein?
Overlapping regulatory peptide whose translation enables hokB expression.
What are the official names of this protein?
Regulatory protein MokB.