PharMolix/UniProtQA huggingface dataset:
Protein: RL15_RHOOB
Sequence: MTIKLHHLRPAPGAKTEKTRVGRGEGSKGKTAGRGTKGTKARKNVPAAFEGGQMPLHMRLPKLKGFTNPFRTEYQVVNVGDIARLFPEGGQVTVEDLVAKGAVRKNQLVKVLGDGDLTVAVQVTVDKFTGSAKEKIAAAGGTATEL
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RS8_DICT6
Sequence: MTVTDPIADMLVRIKNASMRRHPTVDVPYSKMKEKILEILLREGYIARYEVIGEIPQKYIRVYLKYKGKTPVIQDVKRVSKPGRRYYVNKEEIPRVLGGLGIAILSTSKGIMTDKEARLLGVGGELICMVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: GON1_LITCT
Sequence: MSRHVTVVLLLAIVLLLSSHMIHGQHWSYGLRPGGKREVESLQESYAEVPNEVSFTELQHLECSIPQNRISLVRDALMNWLEGENARKKI
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Progonadoliberin-1, Progonadoliberin I.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: KDSB_RHILO
Sequence: MSTLILIPARMASTRLPGKPLADISGAPMIVHVARRAAEAGLGRVVVATDTQSVAEAVRAHGFEAVMTRIDHESGSDRIHEALAALDPGRKVETIVNVQGDLPTIDPGIIAASLRPFEDAAVDIATLGVEIVREEEKTNPNVVKIVGSPLSATRLRALYFTRATAPWGEGPLYHHVGLYAYRRSALERFVALKPSPLERRERLEQLRALEAGMRIDAEIVRSLPLGVDTPQDLERARTILSN
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUFY3_PONAB
Sequence: MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTGELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH
What is the function of this protein?
Plays a role in the generation of neuronal polarity formation and axon growth.  Implicated in the formation of a single axon by developing neurons.  May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes.  Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery.  Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones.  Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner.
What are the official names of this protein?
Protein RUFY3.
What are the subcellular locations of this protein?
Cytoplasm. Endomembrane system. Cell projection, invadopodium. Perikaryon. Cell projection. Cell projection, growth cone. Cell projection, filopodium. Cell projection, lamellipodium. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery. Colocalized with Ras-related Rab-5 proteins in cytoplasmic vesicles. Accumulates in axon growth cones in a F-actin-dependent manner. Colocalized with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones. Colocalized with DBN1 and F-actin at transitional domain of the axonal growth cone.
Protein: INSH6_ECOLI
Sequence: MSHQLTFADSEFSSKRRQTRKEIFLSRMEQILPWQNMVEVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTTIMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPEMHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAEVDVDWLIAERPGKVRTLKQHPRKNKTAINIEYMKASIRAKVEHPFRIIKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRADQMIRQWERSH
What is the function of this protein?
Involved in the transposition of the insertion sequence IS5.
What are the official names of this protein?
Transposase InsH for insertion sequence element IS5H.
What is the protein family that this protein belongs to?
Belongs to the transposase 11 family.
Protein: CLPX_HYDS0
Sequence: MASKKEYCSFCNKSSKDVPLMIAGPNGMNICSECVEKAMDLIKQHDKEEVTKEVRSIPKPKEIKKILDEFIIGQDEAKKILSVAVYNHYKRILRKSDTDIEKSNILLIGPTGSGKTLLAKTLAKILNVPFAIADATTLTEAGYVGEDVENVLVRLLQNCDYNIEKAKKGIIYIDEIDKIAKKSGHNPSITRDVSGEGVQQALLKIIEGTIANVPPQGGRKHPHQEFIQLDTTNILFICGGAFVGLEDIIKRRLGKSTVGFETEISKYKEEGNILSQVEPDDLINFGLIPEFVGRLPVISVLNELTEEDLIRILTEPKNAVIKQYKELLRMEGIGLEFTEGALREIAKEAIKRKTGARGLRAIVEKIMTDIMYEAPSLVNVEKIVIDENKKPVYMYKKAG
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: LGT_BORA1
Sequence: MLQFPQFDPVALRLGPLAIHWYGLMYLLAFAFVYLLGRYRIKRGQGGNLTYKDLEDLIFYSVLGVVLGGRLGYVLFYKPGYYLSHPLEIAFLWEGGMSFHGGLIGVILVMLLFARKKGVSFFTISDFIAPLIPLGLGAGRLGNFINGELWGRPSDLPWAMVFPQSGSMLPRHPSQLYELGLEGLVLFALLWWFSSKPRPSGQVSAMFLMGYGAFRFLVEFTREPDNFLGLLAGGMSMGQWLSLPMFLGGLVLFVLTARRSSRQP
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GRL1A_HUMAN
Sequence: MCSLPRGFEPQAPEDLAQRSLVELREMLKRQERLLRNEKFICKLPDKGKKIFDSFAKLKAAIAECEEVRRKSELFNPVSLDCKLRQKAIAEVDVGTDKAQNSDPILDTSSLVPGCSSVDNIKSSQTSQNQGLGRPTLEGDEETSEVEYTVNKGPASSNRDRVPPSSEASEHHPRHRVSSQAEDTSSSFDNLFIDRLQRITIADQGEQQSEENASTKNLTGLSSGTEKKPHYMEVLEMRAKNPVPQLRKFKTNVLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF
What is the function of this protein?
Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II).  Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery.  Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation.  Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
What are the official names of this protein?
DNA-directed RNA polymerase II subunit GRINL1A, DNA-directed RNA polymerase II subunit M, Glutamate receptor-like protein 1A.
What is the protein family that this protein belongs to?
Belongs to the GRINL1 family.
What are the subcellular locations of this protein?
[Isoform 1]: Nucleus.
Protein: ACM2_CHICK
Sequence: MNNSTYINSSSENVIALESPYKTIEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGIFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPDKDCYIQFFSNPAVTFGTAIAAFYLPVIIMTVLYWQISRASKSRIKKGKKEAAQNQDPVSPSLVQGKIVKPNNNNIPTSSDGLEHNKVQNGKTTGESVMENCVQGEEKDSSNDSTSVSVVPSNTKEDEAAKDASQISASQDHLKVENSKLTCIRIVTKSQKGDCCAPTNTTVEIVGTNGDEKQNSVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWTPYNVMVLINSFCASCIPGTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is adenylate cyclase inhibition.  Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
What are the official names of this protein?
Muscarinic acetylcholine receptor M2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Protein: N4BP2_HUMAN
Sequence: MPRRRKNLGGNPFRKTANPKEVVVSSVASREEPTTTLPSMGETKVDQEELFTSISEIFSDLDPDVVYLMLSECDFKVENAMDCLLELSATDTKIEESSSQSFVASENQVGAAESKIMEKRPEEESEDSKMDSFLDMQLTEDLDSLIQNAFEKLNSSPDDQVYSFLPSQDVNSFNDSSEFINPDSSNMTPIFSTQNMNLNGENLENSGSTLSLNPLPSHSVLNESKCFIKDNTLALESNYPEDSLLSSSLNVASDSIAGCSSLNQKQKELLESECVEAQFSEAPVDLDASEPQACLNLPGLDLPGTGGDQKSTRVSDVFLPSEGFNFKPHKHPELPTKGKDVSYCPVLAPLPLLLPPPPPPPMWNPMIPAFDLFQGNHGFVAPVVTTAAHWRSVNYTFPPSVISHTSPTKVWRNKDGTSAYQVQETPVSQVVRKKTSYVGLVLVLLRGLPGSGKSFLARTLQEDNPSGVILSTDDYFYINGQYQFDVKYLGEAHEWNQNRAKEAFEKKISPIIIDNTNLQAWEMKPYVALSQKHKYKVLFREPDTWWKFKPKELARRNIHGVSKEKITRMLEHYQRFVSVPIIMSSSVPEKIERIELCAYSCEDRSTSPRDDEDIISEKEENILSLSLKHLEFTEEKNLDVTKETMLPENVAYLSNADLNKRRKEISDMNPSIQSALILETPHMYFSDSESKLQATDKSENEQIEMVAVKGYSKTDTDSSMERVSPSTCCSENNQEDCDLANSGPLQNEKSSPGEIVEERATVTKKAFGKQKSKSTLEKFPRHELSNFVGDWPVDKTIGQRTKRNRKTEKTSSVQSDKKYNYPQSHKLVNSVSVNTDCVQQRGSPHESVEDGRKSQCDDASEPLNSYKYDAYKNIDKNSFNIMGDWPSSDSLAQREHRSRMPKTGLSEPNLEIGTNDKMNEISLSTAHEACWGTSSQKLKTLGSSNLGSSEMLLSEMTCESQTCLSKKSHGQHTSLPLTFTNSAPTVSGVVEPQTLAECQEQMPKRDPGKEVGMCTQTEPQDFALLWKIEKNKISISDSIKVLTGRLDGFKPKVFNINTKSDVQEAIPYRVMYDKSTFVEESELTSADESENLNILCKLFGSFSLEALKDLYERCNKDIIWATSLLLDSETKLCEDTEFENFQKSCDGSQIGPFSLGLNLKEIISQRGTLENSNSPVPEFSHGIGISNADSQSTCDAERGNSEQAEMRAVTPENHESMTSIFPSAAVGLKNNNDILPNSQEELLYSSKQSFPGILKATTPKDMSETEKNLVVTETGDNIHSPSHFSDIFNFVSSTSNLELNEEIYFTDSLEIKRNENFPKDYVKFSDEEEFMNEDEKEMKEILMAGSSLSAGVSGEDKTEILNPTPAMAKSLTIDCLELALPPELAFQLNELFGPVGIDSGSLTVEDCVVHIDLNLAKVIHEKWKESVMERQRQEEVSCGKFMQDPSLVGHTGLDNPEQKSSQRTGKKLLKTLTASEMLPLLDHWNTQTKKVSLREIMSEEIALQEKHNLKRETLMFEKDCATKLKEKQLFKIFPAINQNFLVDIFKDHNYSLEHTVQFLNCVLEGDPVKTVVAQEFVHQNENVTSHTGQKSKEKKPKKLKETEETPSELSFQDFEYPDYDDYRAEAFLHQQKRMECYSKAKEAYRIGKKNVATFYAQQGTLHEQKMKEANHLAAIEIFEKVNASLLPQNVLDLHGLHVDEALEHLMRVLEKKTEEFKQNGGKPYLSVITGRGNHSQGGVARIKPAVIKYLISHSFRFSEIKPGCLKVMLK
What is the function of this protein?
Has 5'-polynucleotide kinase and nicking endonuclease activity.  May play a role in DNA repair or recombination.
What are the official names of this protein?
NEDD4-binding protein 2, N4BP2, BCL-3-binding protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_HERAR
Sequence: MADGKIVQCIGAVVDVEFPRNAMPKIYDALKMAGSELTLEVQQQLGDGIVRTIALGTSDGLRRGMIIQNTGNPITVPVGKATLGRIMDVLGNPIDECGPVSHERTASIHRKAPAYDELSPSQDLLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELINNIAKAHSGLSVFAGVGERTREGNDFYHEMADAKVVDLENPENSKVAMVYGQMNEPPGNRLRVALTGLTMAEAFRDEGKDVLFFVDNIYRFTLAGTEVSALLGRMPSAVGYQPTLAEEMGRLQERITSTKTGSITSIQAVYVPADDLTDPSPATTFAHLDSTVVLSRDIASLGIYPAVDPLDSTSRQLDPLVVGQDHYDTARAVQGTLQRYKELRDIIAILGMDELAPEDKLLVARARKMQRFLSQPFHVAEVFTGAPGKYVSLKDTINGFKMIASGELDHLPEQAFYMVGTIEEAIEKAKKLN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: Y1409_SULIA
Sequence: MTNESEVGVKKAAELLRQGATMLEEACPICKMPLFKLKNGDVVCPVHGKVYIVKSDDEEKIVKRNLQLDEIESILIDGLYLSAKKMKEDPLDSERIVQIIRYLDALERLRKIKINSSE
What are the official names of this protein?
UPF0148 protein M1627_1409.
What is the protein family that this protein belongs to?
Belongs to the UPF0148 family.
Protein: YORF3_TTVV9
Sequence: MMMNQLNSLQKLGQETRYPLAEPSKSVAVPLSITSSKSKRRRRHSRSRERKTRKKTRRKQLSSSSSKSSSDKENCSSSSSGGSGDW
What are the official names of this protein?
Uncharacterized ORF3 protein.
Protein: TRHBO_MYCLE
Sequence: MQQSFYDAIGGAETFKAIVSRFYAQVPEDEILRELYPADDLAGAEERLRMFLEQYWGGPRTYSSQRGHPRLRMRHAPFRITAIERDAWLRCMHTAVASIDSHTLDNEHRRELLDYLEMAAHSLVNSAS
What are the official names of this protein?
Group 2 truncated hemoglobin GlbO, Hemoglobin-like protein HbO, Truncated hemoglobin, TrHbO.
What is the protein family that this protein belongs to?
Belongs to the truncated hemoglobin family. Group II subfamily.
Protein: RUVB_CHLP8
Sequence: MRIEALNTAPDATEVRFEEQIRPQSMSDFAGQKKLTDNLKVFITAARKRGDALDHVLLSGPPGLGKTTLAHIIAAEMGGGIKITSGPLIDKAGNLAGLLTSLKKGDILFIDEIHRLAPAVEEYLYSAMEDYRIDILLDSGPASRAVQLKLEPFTLVGATTRSGLLTSPLRARFGINSRLDYYSPELLQSIIVRAAGILNIGVDEDAAMEIARRSRGTPRIANRLLRRARDFAQVANEASISLAVARRTLESLEIDEGGLDDMDKKILEAIVRKFNGGPVGVASLAVSVGEEQDTIEEVYEPYLIQVGYLARTPRGRVATRLAMQRFSYPGMQDHGPLFDHNS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: ECTB_SPOPA
Sequence: MLLTKEKNGMEIIEERESAVRSYSRSFPTVFEKAKDHLVWDVDGKEYIDFFAGAGSLNYGHNNEKMKTKIMDYVMNDGISHSLDMGTVARAEFLETFNEVILRPRNLDYKVMFPGPTGTNTVESALKIARKVTGRQNIISFTNAFHGMTLGSLSISGNSSIRNGAGVPLTNTISMPYDTFFKNGNAIDYLEQYLEDTGSGVDLPAAMILETVQGEGGINAASFEWLRGIEKLCRRYDILLIIDDVQAGCGRTGTFFSFEPAGIQPDIVCLSKSIGGYGLPLAITLIKPEHDIWEPGEHNGTFRGNNMAIVAATEALSYWKTDDLAKSVQKKSKIIKLRFEQIVEDYPELKATTRGRGFMQGIACGKGKEAYATKICAKAFEKGVIMETSGPSGEVVKFLGALTIDETSLIKGLGILEEATEEVVRQ
What is the function of this protein?
Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate.
What are the official names of this protein?
Diaminobutyrate--2-oxoglutarate transaminase, DABA aminotransferase, Diaminobutyrate--2-oxoglutarate aminotransferase, L-2,4-diaminobutyric acid transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: TREM1_MOUSE
Sequence: MRKAGLWGLLCVFFVSEVKAAIVLEEERYDLVEGQTLTVKCPFNIMKYANSQKAWQRLPDGKEPLTLVVTQRPFTRPSEVHMGKFTLKHDPSEAMLQVQMTDLQVTDSGLYRCVIYHPPNDPVVLFHPVRLVVTKGSSDVFTPVIIPITRLTERPILITTKYSPSDTTTTRSLPKPTAVVSSPGLGVTIINGTDADSVSTSSVTISVICGLLSKSLVFIILFIVTKRTFG
What is the function of this protein?
Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses.  Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12.  In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma.  This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:23241959, PubMed:27328755).  By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (By similarity).
What are the official names of this protein?
Triggering receptor expressed on myeloid cells 1, TREM-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Note=Recruited to lipid rafts when activated.
Protein: 3BP1_HUMAN
Sequence: MMKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSHTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRRSLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNPAQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASETN
What is the function of this protein?
GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form.  By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605).  Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260).  Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles.  Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210).  It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway.  Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563).
What are the official names of this protein?
SH3 domain-binding protein 1.
Protein: POPD1_DANRE
Sequence: MSNTTSALPSSVPAVSLDPNATLCQDWEQSHHLLFHLANLSLGLGFLIPTTLALHMIFLRLLLMTGCSLFIAWATLYRCTLDVMVWNVVFLLVNFMHFFFLLYKRRPIKIDRELKSVYKRMFEPLHVREALFQRLTGQFCTIQTLKKGQVYAAEDKTSVDERLSILLKGKMKVSYRGHFLHNIYTNAFIDSPEFRSTQMNRGERFQVTIAAEENCKLLCWSRERLTYFLESESFLNEVFRYLIGKDITNKLYSLNDPTLSDKAVKKMDRQPSLCSQLSMMQMRNSMASTSDTDDVLNQILRGGSTGSSLQKNPLTKTSTTMKPIEEGLEDDVFESESPTTSQNVSKTTKKDI
What is the function of this protein?
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity.  Involved in skeletal muscle and heart development as well as in the maintenance of heart function (PubMed:26642364).  May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules.  Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells.  May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner.  May be involved in epithelial movement during corneal sheet formation and regeneration.  May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity.  May also be involved in striated muscle regeneration and in the regulation of cell spreading (By similarity).
What are the official names of this protein?
Blood vessel epicardial substance, BVES, Popeye domain-containing protein 1, Popeye protein 1.
What is the protein family that this protein belongs to?
Belongs to the popeye family.
What are the subcellular locations of this protein?
Lateral cell membrane. Cell junction, tight junction. Membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Membrane, caveola. Note=Detected at points of cell-cell contact in confluent epithelial sheets. Colocalizes with components of the adherens and tight junctions (By similarity).
Protein: RDRP_I88A3
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETIEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEIEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRVNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPEWFRNILSIAPIMFSNKMARLGKGYMFESKRMKLRTQIPAEMLASIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFSEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.