PharMolix/UniProtQA huggingface dataset:
Protein: Y2523_PECAS
Sequence: MKYQLDAREARVIGCMLEKQITTPDQYPMSLNSITTACNQKTNREPVTELSESEVQQTLDLLVKKHFLRTLSGFGNRVVKYEHRFCNSEFGDLKLSPAEVALVTTLLLRGPQTPGELRTRAARLYDFSDVGEAESTLDQLQQRDDGPFVVRLAREAGKRESRYRHLFSGEASDAAVLEEESVNDNSHPLAERVEALETEVAELKRQLAALLA
What are the official names of this protein?
UPF0502 protein ECA2523.
What is the protein family that this protein belongs to?
Belongs to the UPF0502 family.
Protein: GATA_CENSY
Sequence: MLPESLVEYVREVGSGGTTCEEFTAGAIERTKKQGLDAYITLNEKALDEARRIDSRIKKGEKVGRCLGAPIAVKDNICVRGMRTTCASKMLEGYESPYDATVVTRLLAEDAIITGKTNMDEFAMGLTTEFSAYGPSRNPWNKECTPGGSSGGSAAAVGGLECIASLGSDTGGSVRNPASFCGMVGFKPTYGLVSRYGLVSYANSIEQIGPITRTVEDAAFMMDVISGADPNDATTIECKGGFLDGIDAGIKGKKVGLITEMAGEGIDPRVAEATRDAMAALEDAGARCGKVSLDMVKYSVAAYYTITATEAASNLARYDNTMYGYDMPIESYEFHSYISKARRKFGPEVTRRMILGGFVSSSGHGGRYYHRALKVRGLLAREAEEALAEYDLLLSPTVPILPFKLGEKMGDPVGLFLVDYNTVTANLTGKPAASVPYTVCDGLPVGMQLMGRPSGDAEVLQAAYSLQERSRMPEAPPWQ
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: HMOX1_HUMAN
Sequence: MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTRDGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSFLVATVAVGLYAM
What is the function of this protein?
Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.
What are the official names of this protein?
Heme oxygenase 1, HO-1.
What is the protein family that this protein belongs to?
Belongs to the heme oxygenase family.
Protein: GLMM_AROAE
Sequence: MGRKYFGTDGVRGRVGDSTITPEFVMRLGYAAGVTLVGREQLPPGERPAILIGKDTRISGYMLEAALEAGFAAAGVDVMLAGPVPTPAVAYLTRALRLQAGVVISASHNPYDDNGIKFFSANGTKLPDALEEEIEFRVDQPMVCAEASRLGKARRIVDAAGRYVEFCKSAFPNEFDLRGYRIVLDCAHGAAYHIGPSVFHELGAEVIPLGVEPNGLNINDQVGATHPQTLRSAVLANKADFGIALDGDGDRVVMVDGDGELYDGDKLLYVIAASRQAEGRLEGVVGTLMSNLGLERAIGRLGLAFARAKVGDRYVLETMHERGWRLGGENSGHIICLDRHTTGDGIVSALQVIAALIKGQCTLATACADLVFYPQKLINVPLAAGFDWRSDERIDQARSDAELELGEQGRVLLRPSGTEPLLRVMVEGKDGSQVERLARHIADCVRHASV
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: NSS_PUUMG
Sequence: MSNNLLLPDKNSRMQREQWKWTRMTLTRAHYKQDNKQCQHWRINSQTTREEWQMLCPGRKWILNLLTRLGLNLMIISRRDQALDMEMSLM
What is the function of this protein?
Antagonizes host type-I IFN signaling pathway.
What are the official names of this protein?
Non-structural protein NS-S, NSs.
What is the protein family that this protein belongs to?
Belongs to the hantavirus NS-S protein family.
What are the subcellular locations of this protein?
Host cytoplasm, host perinuclear region. Host cytoplasm.
Protein: SPB10_MOUSE
Sequence: MASLAVSINQFALEFSKKLAESAEGRNIFFSPWGISTALAMLYLGTKGTTADQMAQVLQFSSVEDFKSCPDSEKKRKMEFNSGKFEEIQSDFQTLAAEILKPGNSYVLKTANRIYGEKTYPFHNKYLEDMKTYFGAEPQSVNFVEASGQIRKEINSWVGSQTGGKIPNLLPDDSVDTKTKMVLVNALYFKGTWEHQFSVKNTTERPFRVNKTTSKPVQMMSMKQSLQVFHIEELQTIGLQLHYQNRDLSLLLLLPEAIDGLEQLERAITYEKLDKWTSADMMDTYEVQLYLPKFKMEESYDLKSALRGMGMTDVFSQSKADFSNMTSERNLFLSNVFHKTFLEINEEGTEAAAGTGSEISVRIKAPSIELNVDHPFLFFIRHNKTKSILFCGRFCSP
What is the function of this protein?
Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF.  May regulate protease activities in the cytoplasm and in the nucleus (By similarity).
What are the official names of this protein?
Serpin B10.
What is the protein family that this protein belongs to?
Belongs to the serpin family. Ov-serpin subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: CBHA_EMENI
Sequence: MYQRALLFSALLSVSRAQQAGTAQEEVHPSLTWQRCEASGSCTEVAGSVVLDSNWRWTHSVDGYTNCYTGNEWDATLCPDNESCAQNCAVDGADYEATYGITSNGDSLTLKFVTGSNVGSRVYLMEDDETYQMFDLLNNEFTFDVDVSNLPCGLNGALYFTSMDADGGLSKYEGNTAGAKYGTGYCDSQCPRDIKFINGLGNVEGWEPSDSDANAGVGGMGTCCPEMDIWEANSISTAYTPHPCDSVEQTMCEGDSCGGTYSDDRYGGTCDPDGCDFNSYRMGNTSFYGPGAIIDTSSKFTVVTQFIADGGSLSEIKRFYVQNGEVIPNSESNISGVEGNSITSEFCTAQKTAFGDEDIFAQHGGLSAMGDAASAMVLILSIWDDHHSSMMWLDSSYPTDADPSQPGVARGTCEQGAGDPDVVESEHADASVTFSNIKFGPIGSTF
What is the function of this protein?
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
What are the official names of this protein?
Probable 1,4-beta-D-glucan cellobiohydrolase A, Beta-glucancellobiohydrolase A, Cellobiohydrolase D, Exocellobiohydrolase A, Exoglucanase A.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 7 (cellulase C) family.
What are the subcellular locations of this protein?
Secreted.
Protein: UPP_STRPQ
Sequence: MGKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPLEDVDIQTPVSKTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRNEETLEPVEYLVKLPEDINQRQIFLVDPMLATGGSAILAVDSLKKRGAANIKFVCLVAAPEGVKKLQEAHPDIDIFTAALDDHLNEHGYIVPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: PURT_ECO57
Sequence: MTLLGTALRPAATRVMLLGSGELGKEVAIECQRLGVEVIAVDRYADAPAMHVAHRSHVINMLDGDALRRVVELEKPHYIVPEIEAIATDMLIQLEEEGLNVVPCARATKLTMNREGIRRLAAEELQLPTSTYRFADSESLFREAVAAIGYPCIVKPVMSSSGKGQTFIRSAEQLAQAWEYAQQGGRAGAGRVIVEGVVKFDFEITLLTVSAVDGVHFCAPVGHRQEDGDYCESWQPQQMSPLALERAQEIARKVVLALGGYGLFGVELFVCGDEVIFSEVSPRPHDTGMVTLISQDLSEFALHVRAFLGLPVGGIRQYGPAASAVILPQLTSQNVTFDNVQNAVGADLQIRLFGKPEIDGSRRLGVALATAESVVDAIERAKHAAGQVKVQG
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: Y1401_PYRAB
Sequence: MDMDPWLLLTLILGLAMAWAIGANDAANSMSTAVGAGAITPKQAVLIAGILEFTGAYFFGKTVTETIRKGIIDPSRISDPNVLVYGSLAALLGATIWLVIATKYGLPVSTTHSIIGGIVGYGVVYAGLEIVNWGKMASVVLSWILSPIVGAIFAFFIFKAIRRTVLESEDPIRSAKRWSPVWIGLAFVVIGTMFYIKVLHGKSLYMGVLKLGIPVGLVVFLITSMILRVKFPKVDPYLGAEFIFRRVQVITSGYVALAHGANDVANAIGPVAAVYTIATMGMAGAKVPVPRWILALGGLGIAIGVATYGYRVMETVGKKITELTNTRGFTIDFSAATVVLIASWLGMPISTTHTVVGAVIGVGLARGVKAINKSIVRDIIISWFVTVPVAGLISAIIFKILWIVG
What is the function of this protein?
Potential transporter for phosphate.
What are the official names of this protein?
Putative phosphate permease PYRAB14010.
What is the protein family that this protein belongs to?
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COX3_MYTED
Sequence: MNRNPYSRYYVPGPSPWPFFVAISANGMAVGLILWLHRTPSFLLMGMSLVCMLLSTFSWWRDLIREGDIGFHTRFVIKSFRDCVALFILSEVMFFFTFFWTFFHNALSPSCELGMRWPPPGIRTPNPSSTSLFETGLLISSGLFVTQAHKSMRLKDYDVGPFIGLVVTIVCGTVFFLVQLREYYWNSYTIADSVYGSVFYLLTGFHGMHVVVGTIWLMVSLVRLWRGEFSSQRHFGFEACIWYWHFVDVVWVALWCLVYVWFGGW
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SPEH_METJA
Sequence: MLKYLGKHLILELWGCDPKALDDIEGIEKMLVDSVKACGATLICVRTHKFSPQGATGVAVLAESHIAIHTYPEYGYAALDVFTCGEHTDPYKALEVIREFLKPKSIQIIDLKRGLMENGTFELK
What is the function of this protein?
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
What are the official names of this protein?
S-adenosylmethionine decarboxylase proenzyme, AdoMetDC, SAMDC.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
Protein: CE120_HUMAN
Sequence: MVSKSDQLLIVVSILEGRHFPKRPKHMLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKALHQHRLQRTPIKLQCFALDPVTSAKETIGYIVLDLRTAQETKQAPKWYQLLSNKYTKFKSEIQISIALETDTKPPVDSFKAKGAPPRDGKVPAILAGLDPRDIVAVLNEEGGYHQIGPAEYCTDSFIMSVTIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFNDLINPNFEPERASVRIRSSVEILRVYLALQSKLQIHLCCGDQSLGSTEIPLTGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPIPVELAPTVGVSVALQREGIDSQSLIELKTQNEHEPEHSKKKVLTPIKEKTLTGPKSPTVSPVPSHNQSPPTKDDATESEVESLQYDKDTKPNPKASSSVPASLAQLVTTSNASEVASGQKIAVPATSHHFCFSIDLRSIHALEIGFPINCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGIARIQLSNILSSEKTRFLGSNGEQCWRQTYSESVPVIAAQGSNNRIADLSYTVTLEDYGLVKMREIFISDSSQGVSAVQQKPSSLPPAPCPSEIQTEPRETLEYKAALELEMWKEMQEDIFENQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYTILEGKLQKTLIDLEKREQQLASVESELQREKKELQSERQRNLQELQDSIRRAKEDCIHQVELERLKIKQLEEDKHRLQQQLNDAENKYKILEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKDTVKTERQELLDIRNELNRLRQQEQKQYQDSTEIASGKKDGPHGSVLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREILAKSNASN
What is the function of this protein?
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome.  Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development.  Also implicated in the migration and selfrenewal of neural progenitors.  Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity).  Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865).
What are the official names of this protein?
Centrosomal protein of 120 kDa, Cep120, Coiled-coil domain-containing protein 100.
What is the protein family that this protein belongs to?
Belongs to the CEP120 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.
Protein: TF2B_METTL
Sequence: MATKPVVKEKKKLENKKEIYKLIEHNDSSNKNVILEKEEELICPMCGSKNIIKDYERAEIVCETCGCVLQQNLFDVGPEWRAFDHEQRVKRSRVGPPMTYTIHDKGLSTVIDWRNKDSYGKDISADKRAQLYRLRKWQRRIRVSDASERNLAFALSELDRIASKLGLPRNVRENAAVLYRGAVEKGLIRGRSIEGVAAAALYAACRRCKVPRTLDEIAEGSRVDRKEIGRTYRFISRELNIRLTPTNPIDYVPRFASELKLPGEVESKAISILQKANEKGLTSGRGPTGVAAAAIYIASVLHGTRRTQREVADVAGVTEVTIRNRYKELTEHLDIDVTL
What is the function of this protein?
Stabilizes TBP binding to an archaeal box-A promoter.  Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
What are the official names of this protein?
Transcription initiation factor IIB, TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
Protein: DPO4_CLOK5
Sequence: MHRVIFLVDMNAFFISCESTRHPEIIGKPAAVAGDPKNRSGIILTANYEARKFGVKTTMVLHKVLKLCPNIIIIPPDHCFYKQKSKEVMGILSKYTPVIEKNSIDEAWLDMTGCERIFGRSYQTAECIMKHINSELGLDCSIGISENKFLAKMASQMKKPLGITKLWKKDIELKLWPLPVEFMNGIGKQTARKLREMKIKTIGELANFDRRYLIKKLGKVGAEIHQFANGIDVSPVTPHSHKDVKSIGKSITLAHDISDIESAKVILMELSDKVGMTARKYNKKGHTVQINIKYSNFQSITRQRTITETYLVKEIYSAGIEMLEKNWNERLPVRLLGISLSGFSKYNEDEQISMFNMLEIDNEKSSVRKIDKIEAAIDSIRKKYGDSIIKSGSLIKKSKN
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CIDA2_BACAN
Sequence: MKYVMLLLQVGVLYVFSLVGTWIQGVFHLSMPGSLIGMLMLFLLLSTRILPLKWFEEGAEKLLVFLPLFLIPSTTGLMEYESFLFSKGSIIFLLVVISTVVTLIVSGYISQLLVTSKK
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
What are the official names of this protein?
Holin-like protein CidA 2.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. CidA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TUT1_LEITA
Sequence: MSKYSLLFNQGTKDGTNASSGSEANSANITSSSAPASSTNTSSPTSSESAVVSPPASTSPRRRLIHRRHGSAGAAEVAPLSLPKRPQQPNEEKHENFISDSVHHCSNRGASGSELKALTTSGSETVMSASPDIAFEAPSPPTASASPPLESTSAVESDGDVVIDDMMRYQEGDSGGSRSATSAAAAGRAVSTNDAAALINGDPGPLSSAVSSSSSGSPHTPPRLFTCDMCLQYVSTSYEALEQHALDQHGDALADYTRLRSVAEKLVPVWDEVLKRKASVVQQWGKRIFAVAVQRDAGAEKMAEAHRARAQLELVVQRWHPRAKVFIFGSSVAFGVWDGISDIDFTVVDVDELEAGTWPPSEKNAVRSITELLRRAGFSFINLEPISHARVPIIKHHASLPIRLTDEQRHRLYEEARQSAAAVDLVAAESLASSSPSSAQETTDEKGLTQLEAELIIARSVRYSLNLPAGPPDSAILEASIRLAVGSAAVQQVWWNRTRDMCCMTFDTTTNAVKASTCPLHFMSAGMRARVQPLHEECRPELYGMDFDLSFRAFGIRNSHLLRRYLLSHPCARPGALVLKDWSKTSGVNNSVNGYLTSYAINIMWIYYLVHRGVIRYVCPARDIPASLRCNVDADPQYAAMVDPTWTPEERAAMEAQAGELLLGFFYYYAFEFDWVNHVVSLNRPGITTKASLGWDVEDVAQTGSPAPHFGVAGSQHQYNLAGAEGQQGDLHSGTSLSAPQTRPLTGYDGMMASSASAAARRSRATTRYSFCIEDPYEENLNLGRHMGVTKTLRVQTELYRGLLSLLKDDPQHCCVFAGSTNSSGSTDSNGAMASGAAEPAMVAARTPSEPTELPVRVLYKLMAISTRELAIARRRYSATVTAGTEFPGALLSDLEAAFLAQAPTEWKLARQVWNKHQLLHRLGLKLHAREYVLPRREVGVRRLAAKAPPGVVPASAPEPTFTAEEVAAAAAESGQAPFSAEHAPTSSEEVTQMNRAFLGAFPARRLPEDLMLAMTKGYSCLTPSWVAWSKPWAALSAWWTDRLHSPSTTTQGEDPLASGTCEQGGVSPSLPTGAPHHISAVPEKSAGAMHQTRTQLRRHVVAEIASTPAARRVLRLLFR
What is the function of this protein?
Terminal uridylyltransferase which is involved in the post-transcriptional editing of mitochondrial RNA, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA.  Specifically, catalyzes the addition of Us to the 3'-hydroxyl group of guided RNA (gRNA), with a preference for RNAs terminating in 6 Us, but also can add Us to RNAs terminating in 6 adenines (A), 6 cytosines (C), or 6 guanines (G) (PubMed:11893335, PubMed:15060068).  Can mediate RNA-independent UTP polymerization in vitro (PubMed:15060068).  Can mediate pyrophosphate-dependent degradation of synthetic RNA ending with U residues in vitro (PubMed:15060068).
What are the official names of this protein?
Terminal uridylyltransferase 1, TUTase 1, 3' terminal uridylyl transferase, 3' TUTase, RNA editing terminal uridylyltransferase 1, RET1, RNA editing TUTase 1.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PURR_ERWT9
Sequence: MATIKDVAKRAGVSTTTVSHVINKTRFVADETREAVWVAIKELHYSPSAVARSLKVNHTKTIGLLATSSEAPYFAEIIEAVENSCFAKGYTLILGNAHNNIEKQQAYLSMMAQKRVDGLLVMCSEYPDALISMLEDHRNIPMVVMDWGKSRGDFTDTVLDNAFEGGYLAGRYLIERGHRDIAAIPGQLERNTGGGRHAGFLKALTEAGIVLREEWLVQGDFEPESGYRAMQQILAQKQRPTAVFCGGDIMAMGAICAADEMGLRVPQDISVIGYDNVRNARYFTPALTTVHQPKERLGETAFNMLLDRITSKREESQTIEVYPTLIERRSVADGPYRDYRR
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: UVRB_PROM0
Sequence: MNNYKLQAPYEPNGDQPEAIKKLVKGVNTGKEFQTLLGATGTGKTFTIANVIQQTGRPALVLAHNKTLAAQLCNELREFFPKNAVEYFISYYDYYQPEAYVPVSDTYIAKTASINEEIDMLRHSATRSLFERKDVIVVASISCIYGLGIPSEYLKAAVKFEVGKSINLRSYLRSLVENQYTRNDIEITRGRFRIKGDVLEIGPAYEDRLIRIELFGDEVEAIRYVDPTTGEILESLEQVSVYPAKHFVTPKERLESAISAIRSELKTQLDKFTYEGKLLEAQRLEQRTKYDLEMLKEVGYCNGVENYARHLSGREEGSPPECLIDYFPKDWLLVVDESHVTCPQLHAMYNGDQSRKKVLIDHGFRLPSAADNRPLKCEEFWEKSKQTLFISATPGQWELDQCDGEFIEQVIRPTGVLDPVIDVRPSEGQIEDLLSEIRIRAEKNQRVLVTTLTKRMAEDLTDFLSENKVRVRYLHSEIHSIERIEIIQDLRMGEYDVLVGVNLLREGLDLPEVSLVAILDADKEGFLRAERSLIQTIGRAARHVEGVALLYADNFTDSMKRAISETERRRTIQKKYNQVNGITPKPAGKKIENSILSFLELSRKLDAGGLSKDLINIVNNKTDAILGSSDNQCLLEELPDLIEKLEIKMKDAAKELNFEEAANLRDRIKKLRQKLARNN
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities.  Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer.  DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands.  Then UvrB probes one DNA strand for the presence of a lesion.  If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed.  This complex is subsequently bound by UvrC and the second UvrB is released.  If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
What are the official names of this protein?
UvrABC system protein B, Protein UvrB, Excinuclease ABC subunit B.
What is the protein family that this protein belongs to?
Belongs to the UvrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_SHEHH
Sequence: MQVSVETTQGLERRLTISVPAEQIENTVKEALKSEAKRARIPGFRPGKVPVSVINKRYGNAIRQDITGEVMQRNFIEAIIAEKLNPAGAPTFTPGSTEGENFEFVATFEIYPEVELKGLESITVEQPTAEVTEADVDSMIETLRNQHATFEVAERAAAEGDKAKINFVGSIDGEEFEGGKADDFELQLGSGRMIPGFESGVEGHKAGEEFNIEVTFPEDYHAENLKGKVATFAITLNEVQAANLPEVNDEFATLFGITEGGIDALRGEISKNMSRELEQALKANVKEQVLNGLVEQNDIELPAALIDGEVEVLRKQAMQRFGDQAANMPELPADLFTEQAARRVKVGLLLGEVIKANELKAEDERVQALIASMASAYEDPSEVVAYYNGNEELMQNMRNVALEEQAVEALLKTATLTEKAVNFEEFMNKATGRA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: METK_STAAM
Sequence: MLNNKRLFTSESVTEGHPDKIADQVSDAILDAILKDDPNARVACETTVTTGMALIAGEISTTTYVDIPKVVRETIKEIGYTRAKYGYDYETMAILTAIDEQSPDIAQGVDKALEYRDKDSEEEIEATGAGDQGLMFGYATNETETYMPLAIYLSHQLAKRLSDVRKDGTLNYLRPDGKVQVTVEYDENDNPVRIDTIVVSTQHADDVTLEQIQEDIKAHVIYPTVPENLINEQTKFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGCFSGKDPTKVDRSAAYAARYVAKNIVAAGLADQCEVQLAYAIGVAEPVSIAIDTFGTGKVSEGQLVEAVRKHFDLRPAGIIKMLDLKQPIYKQTAAYGHFGRTDVLFPWEKLDKVEELKDAVKY
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOML_TETMU
Sequence: MAALQEVLLAVLLWPVLVTISNPINCGDEQSSLSNCLSISEEKLLDRESFSTLSSSIVFLKNHVLCLRRCLSHSQYSSRQARQENACMTKVLPIPSSKSEIQQITDKWLLHAVLMLVQSWIKPLVYLQTTMVRYDYASDVLLNKTKWVLEKLISLEQGVVILIKKILNEAVMTTTVSELDLFPTDLQPDILESVMNDYSLLSCFKKDARKIEILLKLLKCRRNDMYNCA
What are the official names of this protein?
Somatolactin, SL.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECR_CHLSY
Sequence: MTVRTDQLIAAPVARLIEEFAKLPGIGPKTASRLTFYLLRAEPKQALALAQAILDVKEQVGYCRRCFNITVGELCAICLDPSRDQTKICVVEEPLDVLAIERTGAYRGLYHVLHGHIAPLEGIYREDLKIEELLARVRSEPVQEVILATNPNTEGEATAFLLLRDLAPLGVRVTRPARGLPTGGDLEWADPETLGSAFEGRREL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.