PharMolix/UniProtQA huggingface dataset:
Protein: Y265_UREPA
Sequence: MNFSSFIFKVSDVFKSVIHEASDVVTKADLDNANAHTHSLAVGLGIGIVLFLIAGLIIGYFISMKIMKRQLKKNPPISKDTIRMIYQQVGRKPSESQINEIYNRAVKQK
What are the official names of this protein?
UPF0154 protein UU265.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GREB_HAEIN
Sequence: MAKSNYITRQGWLALDQELKFLWKEERPKVTQAVSDAAALGDRSENAEYIYGKRRLREIDRRVRFLTKRLEVLQIVDYNPKQEGKVFFGAWVELENEEGETKQYRIVGCDEFAPAKNWISIDSPVARALIGKTLDDEVRVETPSGFITLYVNKIWYEK
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreB releases sequences of up to 9 nucleotides in length.
What are the official names of this protein?
Transcription elongation factor GreB, Transcript cleavage factor GreB.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family. GreB subfamily.
Protein: FOXO4_HUMAN
Sequence: MDPGNENSATEAAAIIDLDPDFEPQSRPRSCTWPLPRPEIANQPSEPPEVEPDLGEKVHTEGRSEPILLPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGNQSYAELISQAIESAPEKRLTLAQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHNEATGKSSWWMLNPEGGKSGKAPRRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKWSGSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPLRPESEVLAEEIPASVSSYAGGVPPTLNEGLELLDGLNLTSSHSLLSRSGLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLSAGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPILSQAPTLLLLGGLPSSSKLATGVGLCPKPLEAPGPSSLVPTLSMIAPPPVMASAPIPKALGTPVLTPPTEAASQDRMPQDLDLDMYMENLECDMDNIISDLMDEGEGLDFNFEPDP
What is the function of this protein?
Transcription factor involved in the regulation of the insulin signaling pathway.  Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.  Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes.  Also involved in negative regulation of the cell cycle.  Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
What are the official names of this protein?
Forkhead box protein O4, Fork head domain transcription factor AFX1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
Protein: Y1038_PYRHO
Sequence: MRRNLTPFFFLLPALTLMVPFVIYPVFKTIYLSFFLGDKFVGLENYKNVLLSPDIVNLERFPTKSPPWGALIHNIVWIAIHLPTTIFLGLGFALLLRKKEVKGSSIIKSIIFLGMVIPMVVGGLIIRFLFEEGAGVIPAFFKLIGIEKLAITWTAYPQTALFSVILGSIWIWTGFSMLMYSAGLASIPKDYYEAALIDGANKFQIFRFVIWPLLRPITVVIVAMTLLWDLKIFDIVYVATGGGPGGASMVLALQMWDYFARSLNYNYAAVVAVLLTALTFIPALWLIKRRG
What is the function of this protein?
Probably part of a binding-protein-dependent transport system PH1036/38/39.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Probable ABC transporter permease protein PH1038.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FABR_ECOBW
Sequence: MGVRAQQKEKTRRSLVEAAFSQLSAERSFASLSLREVAREAVIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRAFTEAQAEAMVTIVFSAGAEALDVGVEQRRQLEERLVLQLRMISKGAYYWYRREQEKTAIIPGNVKDE
What is the function of this protein?
Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis.  By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.
What are the official names of this protein?
HTH-type transcriptional repressor FabR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_BURPS
Sequence: MEIGQYQPNLEGDGLRIGIVQSRFNEPVCNGLADACVEELERLGVSGEDVLLVTVPGALEIPLALQKLAESNQFDALIALGAVIRGETYHFELVSNESGAGITRIALDFNTPIANAVLTTETDEQAIARMTEKGRDAARVAVEMANLTMTLDQLSDDEEDEEDEDDEDEEERA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: NUDI_ECO8A
Sequence: MRQRTIVCPLIQNDGAYLLCKMADDRGVFPGQWALSGGGVESGERIEEALRREIREELGEQLLLTEITPWTFSDDIRTKTYADGRKEEIYMIYLIFDCVSANREVKINEEFQDYAWVKPEDLVHYDLNVATRKTLRLKGLL
What is the function of this protein?
Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
What are the official names of this protein?
Nucleoside triphosphatase NudI, Nucleotide diphosphatase NudI, Pyrimidine deoxynucleoside triphosphate diphosphatase, dCTP diphosphatase, dTTP diphosphatase, dUTP diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. NudI subfamily.
Protein: NQRD_VIBVY
Sequence: MSSAQNIKKSILAPVLDNNPIALQVLGVCSALAVTTKLETAFVMTLAVTFVTALSNFFVSVIRNHIPNSVRIIVQMAIIASLVIVVDQILKAYLYDISKQLSVFVGLIITNCIVMGRAEAFAMKSAPVPSLIDGIGNGLGYGFVLITVGFFRELFGSGKLFGMEVLPLVNNGGWYQPNGLMLLAPSAFFLIGFMIWAIRTFKPEQVEAKE
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL6_LEPBJ
Sequence: MSRIGKAEIKLPDKVEVKQENANIKVKGPLGELSTPIFEGLSVKNENGIVKLERSNEDQKVVALHGLTRALLMNCVKGVSQGWEKNLEINGVGYRAQKRGEDLVMSLGYSHEVVYKAPKGIKIDVQEQLKIKVTGIDKQLVGQVAADIRSKRPPEPYKGKGIKYAEEFIKKKAGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: DCLK2_AILME
Sequence: MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLMELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTARALAAPSSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVKRGGHHASAYSAARSPVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELARCLSPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECMDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGEILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSSRPGMELTSPVPPSASAEEPPVSAPAAAPAPLESPTPPGTPAASGCERAGTWRRHRD
What is the function of this protein?
Protein kinase with a significantly reduced Ca(2+)/CAM affinity and dependence compared to other members of the CaMK family.  May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase DCLK2, CaMK-like CREB regulatory kinase 2, CL2, CLICK-II, CLICK2, Doublecortin-like and CAM kinase-like 2, Doublecortin-like kinase 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.
Protein: PSMA2_STAAR
Sequence: MGIIAGIIKFIKGLIEKFTGK
What is the function of this protein?
Peptide which can recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against infection.
What are the official names of this protein?
Phenol-soluble modulin alpha 2 peptide.
What is the protein family that this protein belongs to?
Belongs to the phenol-soluble modulin alpha peptides family.
Protein: SBT3_LOTJA
Sequence: MTKVVQFSLLLALILVLSVSLASAASQNLEFTELEDEDQSNLSTYIVHVRKPQVIQSDDLHTFYYSLLPESTKTTNQRIVFTYRNVVNGFAVKLTPEEAKALQQNEEVVSARPEKILSLHTTHTPSFLGLQQGLGLWKGSNSGKGVIIGILDTGISPFHPSFSDEGMPSPPAKWNGICEFTGKRTCNNKIIGARNFVKTKNLTLPFDDVGHGTHTASTAAGRPVQGANVYGNANGTAVGMAPDAHIAMYKVCGLVGCSESAILAGMDTAVDDGVDVLSLSLGGPSGPFFEDPIALGAFGAIQKGIFVSCSAANSGPAYSSLSNEAPWILTVGASSIDRTIMATAKLGNGKEYVGQSVFQPKDFAPSLLPLVYAGANGNNNFSVFCAPESLNRSDVEGKVVLCEDGGFVPRVFKGKAVKDAGGAAMILMNSVLEDFNPIADVHVLPAVHISYEAGLALKEYINSTSTPTATILFEGTVIGNLLAPQVTSFSSRGPSKASPGILKPDIIGPGLNILAAWPVSLDNSTTPPFNIISGTSMSCPHLSGIAALLKNSHPDWSPAAIKSAIMTTASQVNLGGTPILDQRLVPADVFATGAGHVNPVKANDPGLVYDIEPNDYIPYLCGLNYTDREVGVILQQRVRCSEVNHIAEAELNYPSFSILLGNTTQLYTRTVANVGPANSTYTAEIGVPVGVGMSLSPAQLTFTEVGQKLTYSVSFIPFSEDRDNHTFAQGSLKWVSGKYSVRSPISFIFL
What is the function of this protein?
Required for arbuscular mycorrhiza (AM) development during AM symbiosis with AM fungi (e. g.  Glomeromycota intraradices).
What are the official names of this protein?
Subtilisin-like protease 3, SbtM3, Subtilase 3.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast. Note=Accumulates in the intercellular spaces and the periarbuscular space (PAS) during arbuscular mycorrhizal (AM) symbiosis.
Protein: RS18_STAAC
Sequence: MAGGPRRGGRRRKKVCYFTANGITHIDYKDTELLKRFISERGKILPRRVTGTSAKYQRMLTTAIKRSRHMALLPYVKEEQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MOAA_SINMW
Sequence: MNTAAIDQTNARSLDSTTASMVDPFGRAVTYLRVSVTDRCDFRCTYCMAEHMTFLPKKDLLTLEELHRLCSAFIAKGVRKLRLTGGEPLVRKNIMFLIRELGKEIEAGRLDELTLTTNGSQLSKFAAELVDCGVRRINVSLDTLDPDKFRQITRWGELTKVLEGIDAALAAGLKVKINAVALKDFNDAEIPELMRWAHGRGMDLTLIETMPMGEVDEDRTDHYLPLSEMRKRLEADFTLKDMSYRTGGPARYVDVLETGGRLGLITPMTHNFCESCNRVRLTCTGTLYMCLGQNDAADLRSALRATEDDAYLAQVIDDAISRKPKGHDFIIDREHNRPAVARHMSVTGG
What is the function of this protein?
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
What are the official names of this protein?
GTP 3',8-cyclase, Molybdenum cofactor biosynthesis protein A.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MoaA family.
Protein: PVK2_GYNCS
Sequence: GSSGLISMPRV
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, GynCa-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CNBL1_ARATH
Sequence: MGCFHSKAAKEFRGHEDPVKLASETAFSVSEVEALFELFKSISSSVVDDGLINKEEFQLALFKSRKRENIFANRIFDMFDVKRKGVIDFGDFVRSLNVFHPNASLEDKIDFTFRLYDMDCTGYIERQEVKQMLIALLCESEMKLADETIEIILDKTFEDADVNQDGKIDKLEWSDFVNKNPSLLKIMTLPYLRDITTTFPSFVFHSEVDEIAT
What is the function of this protein?
Acts as a calcium sensor involved in the signaling pathway during growth and development and in response to abiotic stresses.  May function as a positive regulator of salt and drought responses and as a negative regulator of cold response.  Contributes to the regulation of early stress-related CBF/DREB transcription factors.  CBL proteins interact with CIPK serine-threonine protein kinases.  Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.  Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement.  Involved in response to glucose and gibberellin during germination and seedling development and in response to cold stress.  Involved in the calcium-dependent regulation by CIPK26 of reactive oxygen species production by the NADPH oxidase RBOHF.
What are the official names of this protein?
Calcineurin B-like protein 1, SOS3-like calcium-binding protein 5.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=The cell membrane localization is S-acylation dependent and is abolished by 2-bromopalmitate (2-BP) treatment.
Protein: SEC31_YARLI
Sequence: MKLKEIDRTATFAWSPNNLRIATGTVAGTVDADFSSSSQLEIWDVDLMDRSSEGFRLTKPAVSISADTRFHDLVWHNTGKHSLIVGATESGSLEVWEADNIKDSSTSVSVKEHSGPIKTLQFDPHNPTRLVSGGTKGEIFVWDLSDPKKPIAKKLGTDNKAGDIESLAFNNITRNILATSSSNGITTIWNVDQNKELTRVKHDKPVSHVVWHPSKPTKLITAVADDAEPVMLIWDLKNANAPEGVLQGHSKGILSVDWCQLDPRFLLSCGKDNRTLLWNPDTHECLGEYGAAQNWTFKTKLNERTPDLFATASFEGKIVIQTLQDVNGGDAPAQEGDFFQNLGTQSQAKISLKQAPSWLQRPVSNSFGFGGKIVTVTTTDGKSTVQVGKFVGDKVDTESIEVVLKGDLTSAFDEVKGAEWKVLEALSKGTDEVRSFLDIPVMKEEPAVEDDSEDVFSKMSPSGAFSLESSDPINQAIINGNLSTAVDLCLKEDRLLDAFALAEKASDAVKTKVQNAYFAKQTSSTARLLNAVNTNKLDDVVENANLKDWKEILALLYTYGGAQFGDLAAALGDRLRESDRDNAATCYLVSGKLDKVSGLWESEITTREKELTKDNVAPYTAHFSALKEFIEKISVFRKATNAVDSGTVDGLYNKYREFANIVASQGNLELAQQFLALLPASFEGVGLERERLNKAAKPSVATTATSKASAYGKPSYGSATPQASAYTPTASAYGSMYAPAVPAAAAPAAAAPPPTAAAVPPSPAKNMYAPQPPAPVTGFAPAAQSPGAPQQNTHNPYNPTPQTNAYAPQGNAYSAAPQQNTYGRSTPGGGPVRTTAPRHDTAGYNDLPAGSVPPPKKSAPSPGPISSAYAPPTPAAPSAPPAGGPRPPSVNRVTSPGVPSGGVNAYGFPIGGAPSPYGAQAAYGARPPVPAVVSPPPPNPYAPAHSPAQNNVQPAVNPYAPAPGAVVSPPPVHAGIVPPPAQRSAPSNPYAPAPGAGAPPASNPYAPPTGGFTGAPAPHAGGGYTAPPPAQVAPPPAGPPRNSVAPPPGGPARNPVPSSPAPPPAAAKHPAGDRTHIPATSRPIFDTLSTQWAGLKPHIPEQYSKHVRDAEKRLNILYDHLNNDDAQPEMVEDLLKLSNAIAQRDFPTAQALQLQIATARPDECGKWMVGLKRFVEMAAAVRTW
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
What are the official names of this protein?
Protein transport protein SEC31.
What is the protein family that this protein belongs to?
Belongs to the WD repeat SEC31 family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DISA_CLOBB
Sequence: MRLEKGMKIKDTLKIMCPGTQLREGLENILRAKTGGLIVIGDNKEVMDTVDGGFNLNSDYSPSYVYELAKMDGAIVISEDLKKIVCANAQLIPDPSIVTHETGTRHRTAHRIAKQTNNIVIAISQRRNIITVYKGDIKYVLRDSSVILARANQAIQTLEKYVSVLERVINNLNLLEFQDLTTLFDVVTAIQRTEMVMRIVEEINMYILELGNEGRLISMQLNELVKHIERDGILLIRDYCKDEDGHNEVYEQIQKLSATELLDLDAIARVLGHAGESLVDTLISAKGYRILGKVPRIPSTVIENLIKEFKELNSVIEADIDELDIVEGIGEARAKAIKDGLKRIREQILLNKKI
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: RL32_ECO27
Sequence: MAVQQNKPTRSKRGMRRSHDALTAVTSLSVDKTSGEKHLRHHITADGYYRGRKVIAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: METE_STRGC
Sequence: MSTTIIGFPRLGEFRELKFTTEKYFRKEISADELLAAAKELRAKHWNIVKEKGISEIPSNDFSHYDNVLDAAFLFNVVPSSVRGLELTDLERYFALARGYQGEKGDVRALPMKKWFNTNYHYIVPKFEKETQVKLAGHKIFEEFAEAKELGLVTRPVVVGPFTLLQVSDFEDGVAPADFVDALATAYQEVFAKLAELGAKRIQLDEPSLVKDLSAEEKALFLDLYKKLLADKKGLEVLIQTYFGDVRDIYSDLVQLPVDAIGLDFVEGKKTLELVKGGFPADKTLYAGIVNGKNIWRNNYEKSLAVLEQIPAENIVLTSSCSLLHVPFTTANEEFEPAILNHFAFAVEKLDEIRDLDAIRNGQGAEALAANKELFATERVGENAELRARIAGLTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAFRKGELSAEDYDKFLAEQIDEWIKWQEEVGFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGMRGVKPPIIWGDVTRLNPITVKWSSYAQSRTEKPVKGMLTGPVTILNWSFPREDISIKDSTLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVHSTVAPDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVGPGVYDIHSPRVPNEGEIDHTIEAILAKVPSKKVWINPDCGLKTRGIPETKASLVRLVEAAKAARQHLK
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: CTGE6_HUMAN
Sequence: MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQESLQSENIYFESENQKLQQKLKIMTEFYQEDEMKLYRKLTVEENYRIEEEEKLSKVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF
What are the official names of this protein?
cTAGE family member 6, Protein cTAGE-6.
What is the protein family that this protein belongs to?
Belongs to the cTAGE family.
Protein: DCC1_XENLA
Sequence: MSRSQEELEATLQIAKVNPEDLRSTVHCLSFSSEFTSGDYSLMELDDTLCKQIEAGDSLVIRGDKSDHAVLCSQDKTYDLKIADTSNLLLFIPGCKLPDQLPADQQPLSVIHCEIAGFSNHYWELRRCRPKLKKLKKLLMENTYNGPENESESSQETSLYTTEDLLSVIQSSTEELMDHLKAIHACNIKGIWRLLDFDYEMKLLNHITQLIDSESWSFSKVPLQVCLQELRSLEPEEMIEHCLTCYGKRLMEEGGDCFALDEDKICRATALMLLQNAVKFNLAEFQEVWQQSVPDGMNTRLDQLKGLALVDRTSRPETIFLLQTEDLPEDTQERFNTLFGMREKWTEADIAPYIQDLCGEKQTIGALLTKYARSSMQNGIKLFNSRRPLS
What is the function of this protein?
Loads pcna onto primed templates regulating velocity, spacing and restart activity of replication forks.  May couple DNA replication to sister chromatid cohesion (By similarity).
What are the official names of this protein?
Sister chromatid cohesion protein DCC1.
What is the protein family that this protein belongs to?
Belongs to the DCC1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIHA_ECO7I
Sequence: MALPILLDCDPGHDDAIAIVLALASPELDVKAITSSAGNQTPEKTLRNVLRMLTLLNRTDIPVASGAVKPLMRDLIIADNVHGESGLDGPALPEPTFAPQNCTAVELMAKTLRESAEPVTIVSTGPQTNVALLLNSHPELHSKIARIVIMGGAMGLGNWTPAAEFNIYVDPEAAEIVFQSGIPVVMAGLDVTHKAQIHVEDTERFRAIGNPVSTIVAELLDFFLEYHKDEKWGFVGAPLHDPCTIAWLLKPELFTTVERWVGVETQGKYTQGMTVVDYYYLTGNKPNATVMVDVDRQGFVDLLAERLKFYA
What is the function of this protein?
Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively.
What are the official names of this protein?
Pyrimidine-specific ribonucleoside hydrolase RihA, Cytidine/uridine-specific hydrolase.
What is the protein family that this protein belongs to?
Belongs to the IUNH family. RihA subfamily.
Protein: S1PR2_RAT
Sequence: MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV
What is the function of this protein?
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10383399).  S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10383399).  Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251).  Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (PubMed:29453251).
What are the official names of this protein?
Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, AGR16, Endothelial differentiation G-protein coupled receptor 5, G-protein coupled receptor H218, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DAPE_CUPTR
Sequence: MNPTLALTEDLIRRRSVTPADEGCQAILETRLKAIGFDCEALVSGPDDFRVTNLWAVKRGTQGKDGKLLVFAGHTDVVPTGPLEQWHSDPFAPTHRDGKLYGRGAADMKTSIAGFVVAVEEFVKAHPAHAGSIGFLITSDEEGPAHDGTIKVVEALSARGERLDYCVIGEPTSVNALGDMVKNGRRGSLSGKLTVKGIQCHIAYPHLGRNPIHDAAPALAELAAEVWDAGNEYFPPTSWQMSNIHGGTGATNVIPGHVTIDFNFRFSTASTPEGLKARVHAILDRHSLDYTLDWTLGGEPFLTPRGELSEALSSAIKAETGFDTELSTTGGTSDGRFIARICPQVIEFGPPNASIHKIDEHVEVRFIEPLKNVYRGVLERLIA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: RL17_CAUVN
Sequence: MRHGKAHRKLGRTSAHRTAMFANMSASLIKHEQIVTTLPKAKELRPIVEKLVTLAKRGDLHARRQAISSVRDVEQVGKLFAVLGPRYKERQGGYIRVLKAGFRYGDNAPMAVIEFVDRDVSEKGKDSGPVYVNDAED
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.