PharMolix/UniProtQA huggingface dataset:
Protein: PRO_HTL1A
Sequence: MGQIFSRSASPIPRPPRGLAAHHWLNFLQAAYRLEPGPSSYDFHQLKKFLKIALETPARICPINYSLLASLLPKGYPGRVNEILHILIQTQAQIPSRPAPPPPSSPTHDPPDSDPQIPPPYVEPTAPQVLPVMHPHGAPPNHRPWQMKDLQAIKQEVSQAAPGSPQFMQTIRLAVQQFDPTAKDLQDLLQYLCSSLVASLHHQQLDSLISEAETRGITGYNPLAGPLRVQANNPQQQGLRREYQQLWLAAFAALPGSAKDPSWASILQGLEEPYHAFVERLNIALDNGLPEGTPKDPILRSLAYSNANKECQKLLQARGHTNSPLGDMLRACQTWTPKDKTKVLVVQPKKPPPNQPCFRCGKAGHWSRDCTQPRPPPGPCPLCQDPTHWKRDCPRLKPTIPEPEPEEDALLLDLPADIPHPKNLHRGGGLTSPPTLQQVLPNQDPASILPVIPLDPARRPVIKAQVDTQTSHPKTIEALLDTGADMTVLPIALFSSNTPLKNTSVLGAGGQTQDHFKLTSLPVLIRLPFRTTPIVLTSCLVDTKNNWAIIGRDALQQCQGVLYLPEAKRPPVILPIQAPAVLGLEHLPRPPEISQFPLNQNASRPCNTWSGRPWRQAISNPTPGQGITQYSQLKRPMEPGDSSTTCGPLTL
What is the function of this protein?
The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane.  Cleavages take place as an ordered, step-wise cascade to yield mature proteins.  This process is called maturation.  Displays maximal activity during the budding process just prior to particle release from the cell.  Cleaves the translation initiation factor eIF4G leading to the inhibition of host cap-dependent translation.
What are the official names of this protein?
Gag-Pro polyprotein, Pr76Gag-Pro.
What are the subcellular locations of this protein?
[Matrix protein p19]: Virion. SUBCELLULAR LOCATION: [Capsid protein p24]: Virion. SUBCELLULAR LOCATION: [Nucleocapsid protein p15-pro]: Virion.
Protein: PSIE_SHIDS
Sequence: MTSLSRPRVEFISTILQTVLNLGLLCLGLILVVFLGKETVHLADVLFAPEQTSKYELVEGLVVYFLYFEFIALIVKYFQSGFHFPLRYFVYIGITAIVRLIIVDHKSPLDVLIYSAAILLLVITLWLCNSKRLKRE
What are the official names of this protein?
Protein PsiE.
What is the protein family that this protein belongs to?
Belongs to the PsiE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: XPT_LACPL
Sequence: MRELEERILKDGRVLPGEVLKVDGFLNHQVDPDLMFAMGTEFAHLFQDAGVTKILTVESSGIAPAVMAGLAMHVPVVFARKHKSVTLIDDLYTAEVYSYTKKTSNHISIAKKFLQADDQVLLIDDFLANGQAVQGMFEICDKAHVKIAGVGIVIEKVFQTGHQLIADRGVRLESLAQITSFDGDRVHFASEDTQA
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_DROYA
Sequence: MSTSATNGTHYEQLHQGRTKMYKSKVDVVLGAQWGDEGKGKVVDMLASDVDIVCRCQGGNNAGHTVVANGTEFDFHLLPSGVVNEKCVSVIGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGNGVVIHLPSLFDEVLKNEAKGLQHLENRLIISDRAHLVFDFHQHVDGMQEAEKGGKSLGTTKKGIGPAYSSKATRNGIRVGELLGDFNLFSEKFKSIVATHVRLFPSINVDVEAELARYKDYADKVRPYVKDTICFLHTALRNGKTILVEGANAAMLDIDFGTYPYVTSSNCSIGGVLTGLGLPPQTIGEVIGVVKAYTTRVGDGPFPTEQLNDIGDLLQTRGFEIGVTTKRKRRCGWLDIPLLKYTSLVNGYTCICVTKLDILDTLPEIKVAVAYKKPNGEKLDHFPGTIAELGSIEVEYAVLPGWQTSTEDVRNFKELPENAQSYVRFLESELSVPVRWVGVGKGRESIINVH
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_ARTGO
Sequence: MTASLLSGKPLAKLIQQQAQTEAKVLAEEGTCPTLAVVVATEDSSTHWYVRSIERAAEAAGINCRIIDVGHDATEQVLIAVLKDLSAELSVNGIILQTPLPPGVRTQELVKYIAPEKDIDGANPLSLGLLAVGERAFAPATARAVVEILDHFEIPVAGRNVVVVGRSTVVGKPLSLLLLQKDATTTVCHSKSGALGTYTKTADVVVVAAGRTGLLTGADVSEHSVVIDVGTNVLSDGSLTGDVDEASVRPVAAALTPVPGGVGSVTTALLLLHTAEAAREQSRATSAPVLTR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL23_DESVV
Sequence: MDYTKILIKPLISEKTTYIKELSRQVAFFVDPRANKIEIKKAVEAAFKVKVADVNVVNRKSSDRVRQGRVVGRVAGFKKAYVTLAPGEKIEFFEGV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: FRA12_FRAAN
Sequence: MGVFTYETEFTSVIPPPRLFKAFILDADNLIPKIAPQAVKCAEIIEGDGGVGTIKKITFGEGSQFGSVTHKIDGIDKENFVYSYSLIEGDALSDKIEKISYETKLVSSSDGGSIIKSTSNYHTKGDVEIKEEHVKAGKEKASHLFKLVEGYLLANPNEYC
What is the function of this protein?
Involved in the control of flavonoid biosynthesis in fruits, probably by binding directly to natural flavonoids (By similarity).  Binds the natural flavonoid myricetin with affinities in the low micromolar range (PubMed:24133217).
What are the official names of this protein?
Major strawberry allergen Fra a 1-2, Class 10 plant pathogenesis-related protein Fra a 1.02, PR10-related protein Fra a 1.02.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: CNU_SHIF8
Sequence: MTVQDYLLKFRKISSLESLEKLYDHLNYTLTDDQELINMYRAADHRRAELVSGGRLFDLGQVPKSVWHYVQ
What is the function of this protein?
Modifies the set of genes regulated by H-NS; Hha and cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA.  The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC.
What are the official names of this protein?
OriC-binding nucleoid-associated protein, H-NS/StpA-binding protein 2, Transcription modulator YdgT.
What is the protein family that this protein belongs to?
Belongs to the Hha/YmoA/Cnu family.
Protein: ATPD_ENT38
Sequence: MSEFVTVARPYAKAAFDFAVEHQNVDRWQDMLAFAAEVTKNEQMAEMLSGALAPETLAASFIAVCGEQLDTSGQNLIKVMAENGRLRVLPDVLEQFEHLRALSEATAEVEVTSANELSEEQLAKITAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLQRLSDVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: OPSD_CAMAT
Sequence: MMSIASGPSHAAYTWASQGGGFGNQTVVDKVPPEMLHMVDAHWYQFPPMNPLWHALLGFVIGVLGVISVIGNGMVIYIFTTTKSLRTPSNLLVVNLAISDFLMMLCMSPAMVINCYYETWVLGPLFCELYGLAGSLFGCASIWTMTMIAFDRYNVIVKGLSAKPMTINGALIRILTIWFFTLAWTIAPMFGWNRYVPEGNMTACGTDYLTKDLFSRSYILIYSIFVYFTPLFLIIYSYFFIIQAVAAHEKNMREQAKKMNVASLRSAENQSTSAECKLAKVALMTISLWFMAWTPYLVINYSGIFETTKISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALFQKFPSLACTTEPTGADTMSTTTTVTEGNEKPAA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PGK_PSEPG
Sequence: MTVLKMTDLDLQGKRVLIREDLNVPVKDGVVASDARILAALPTIKLALEKGAAVMVCSHLGRPTEGEFSAENSLKPVADYLSKALGRDVPLVADYLDGVSVQAGELVLFENVRFNKGEKKNADELAQKYAALCDVFVMDAFGTAHRAEGSTHGVAKFAKVAAAGPLLAAELDALGKALKAPAKPMAAIVAGSKVSTKLDVLNSLSSVCDQLIVGGGIANTFLAAAGHPVGKSLYEPDLVDTAKAIAAKVSVPLPVDVVVAKEFAETAEATVKAIADVAADDMILDIGPQTAANFAELLKSSKTILWNGPVGVFEFDQFGNGTKVLAKAIADSAAFSIAGGGDTLAAIDKYGVSKEISYISTGGGAFLEFVEGKVLPAVAILEERAKA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPUA_BACAN
Sequence: MKKILSIFIVVFLFAVGCGQQKEEKKETKADNKNQAITIKHAEGETKLDKPAKKVVVLEWVYSEDLLALGVQPVGMADIKNYNKWVNTKTKPSKDVVDVGTRQQPNLEEISRLKPDLIITASFRGKAIKNELEQIAPTVMFDPSTSNNDHFAEMTETFKQIAKAVGKEEEGKKVLADMDKAFADAKAKIEKADLKDKNIAMAQAFTAKNVPTFRILTDNSLALQVTKKLGLTNTFEAGKSEPDGFKQTTVESLQSVQDSNFIYIVADEDNIFDTQLKGNPAWEELKFKKENKMYKLKGDTWIFGGPESATSLATQVADVMTAKK
What is the function of this protein?
Part of an ABC transporter complex involved in ferric-petrobactin uptake.
What are the official names of this protein?
Petrobactin-binding protein FpuA, Petrobactin receptor.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 8 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Extracellular side.
Protein: C20AA_BACUF
Sequence: MNPYQNNDEIVDVPENYDNNLNRYPYANDPNVAMQNTNYKDWMNGYEEINPSSITAILASIGILNRVIALTGVLGNTQEVISIIQDALGFIRNGTGNELLIHVEQLIQQTLATQYRSAATGAIYGISRSYDNYLMFFRQWERNRTRENGQQVESAFTTINTLCINALAPQASLSRRGFETLLLPNYAMAANFHLLLLRDAVLYRNQWLSNSISTANVNLNILRAAINEYITHCTRWYQDGLNRFDRSSRANMNEWRRFNAYRRDMTLSVLDFATVFPTYDPVLFPAATNVELTRVVYTDPIVMAGGRTAIPGFTRMENLVNSASRVSFLNQMNIYTSFYFRPHNIPRYYWSGNQNFLSNGTSNLYGYRSDGRTTFNVSNIDIFRVNMTTHIGGAFTDDYRGLHRAEFIGANTQNNQRTSLLYSVEIPSSHFRFENHTVFLPGESGLEPNERNYTHRLFQMMNEVSVNPNARGRVFLHAWTHRSLRRTNGLRSDQILQIPAVKTISNGGDRAVVLNYGENIMKLDNLTTGLSYKLTAVDSEASNTRFIVRVRYASMNNNKLNLVLNGAQIASLNVEHTVQRGGSLTDLQYGNFKYATFAGNFKMGSQSILGIFKEIPNIDFVLDKIELIPSNFMSSLEQTQNYNTYNQDTIYTHNQGYDTYDQNSSGMYHQSYNNYDQNMDTTYQPSYDNYNQNASGTYDDGYNPNASDSYDQSYTNNYSQNTNSMYDQGYYNNNYDQHSGCTCNQGYDNNYLK
What is the function of this protein?
Promotes colloidosmotic lysis by binding to the midgut epithelial cells of mosquitos.  Active against Aedes aegypti and Culex quinquefasciatus larvae.
What are the official names of this protein?
Pesticidal crystal protein Cry20Aa, 86 kDa crystal protein, Crystaline entomocidal protoxin, Insecticidal delta-endotoxin CryXXA(a).
What is the protein family that this protein belongs to?
Belongs to the delta endotoxin family.
Protein: SAES_STAES
Sequence: MTIFSIRSQIIIGVISSVILTTIILVIAYKLMWFNGHMTLTLAITTMITSCLTLSICSIFINPLIQKIKQFNIKTKQFINHEKFIDDETFQSPREIKELNDSFNKMAYEINNQMNMIKNEQQEKTEIIQNLAHDLKTPLAGIRSYSEGLRDGVISDPQEVHEAYEILIKQANRLSILFDDITHVINLNTGRSYPLELIQLDQLLVNILQPYEQHIKQENRTLEVNFCTDIDAFYQYRPPIERILTNLLDNALKFSNSGSRIDIIISECKENDVISISIKDEGIGIVPELQSRIFERTFRVEDSRNTKTGGSGLGLYIANELAQQIDASITVQSDLDIGTTMTLTLKKFQFKK
What is the function of this protein?
Member of the two-component regulatory system SaeR/SaeS.  Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR (By similarity).
What are the official names of this protein?
Histidine protein kinase SaeS, Sensor protein SaeS.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FGFR3_HUMAN
Sequence: MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis.  Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development.  Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.  Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation.  Required for normal development of the inner ear.  Phosphorylates PLCG1, CBL and FRS2.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  Plays a role in the regulation of vitamin D metabolism.  Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling.  Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B.  Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.
What are the official names of this protein?
Fibroblast growth factor receptor 3, FGFR-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor. SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single- pass type I membrane protein. SUBCELLULAR LOCATION: [Isoform 3]: Secreted. SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single- pass type I membrane protein.
Protein: BMNL2_BOMOR
Sequence: GIGSAILSAGKSALKGLAKGLAEHFAN
What is the function of this protein?
Has antimicrobial activity, but no hemolytic activity.  Preference on killing Gram-negative non-enteric bacteria.
What are the official names of this protein?
Bombinin-like peptide 2, BLP-2.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TXLF3_CYRHA
Sequence: GCLGDKCDYNNGCCSGYVCSRTWKWCVLAGP
What is the function of this protein?
Agglutinates erythrocytes.
What are the official names of this protein?
U2-theraphotoxin-Hhn1a, U2-TRTX-Hhn1a, Hainantoxin F3-25.85, Peptide F3-25.85.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 51 (Hntx-8) subfamily. Hntx-8 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SYFA_JANMA
Sequence: MNPLEQLVTQAQTDFAAAIDAAALENAKAKYLGKTGQITEQMKSLGKLAPEERKAQGAVINSAKEKIEAALTARRDALSNAQMEARLNAEAIDITLPGRGRGTGGIHPVMRSWQRVEEIFGSIGFDVADGPEIENDWTNFTALNSPENHPARSMQDTFYIEGKDTQGKPLLLRTHTSPMQVRYARMNKPPIKVIAPGRTYRVDSDATHSPMFHQVEGLWIDENISFADLKGVYLNFVKAFFETDDLQVRFRPSYFPFTEPSAEIDIAFGSGPLKGRWLEVSGAGQVHPTVLRNMGFDPEQFIGFAFGSGLERLTMLRYGINDLRLFYEGDLRFLKQFN
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HOOK_DROPE
Sequence: MSAAKNEMYYSLLEWFKTLNLNAPHADAESLADGVAVAQALNQFAPESFTDSWLAKIKASAVGINWRLRMSNLKKVTQSLYDYYSEVLNYTLSDFVKPDVQRIAEKCDLVELERLLQLVLGCAVNCAKKQSYITEIMCLEEELQANIMRALQELESSRNAAEGGIVTSLSRSSISGMLDGKVLQEERDAMAQKCFETEKKMLLLIDEKTNLQQELQRVQKEFARLEHSSTVIGDDGVSLGPVQTGSVRYNELRRQLDLLKEELLQSEGAREDLKLKAQQQETDLWHMQMRIDELLKSTAEVTTLKDEVDVLRESNDKLKICEGQLDTYKKKLEDYNDLKKQVKILEERSADYVQQNAQFEEDAKRYANTKGQIELFKKEIQDLHTKLDSESSKNVKLEFDNKNLEGKNLALQRAKDSLLKERDNLRETVDELKCGHLSSNSGLTGTTVSRELQPPATVEKMQRLEAENKALREGQGGQTALAQLLDDANKRCENLREQLKTANERILSLSHASQSDDPILKESEFGKQIKQLMELNEQKTLQLEESVTQSSSLQCKVTQLETNLTAREQEVMAYDAKYRKCLEKAKEVIKSFDPRIASAIDASALEKYFDVVEEEPKPKMSVMEEQLMTSAFYRLGVNAQRDAVDSKLAILMGSGQTFLARQRQSAPRKSLSAMKSK
What is the function of this protein?
Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway.  Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton.  Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size.  Not involved in synaptic vesicle recycling.  Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs).  Has a role in regulating adult longevity.
What are the official names of this protein?
Protein hook.
What is the protein family that this protein belongs to?
Belongs to the hook family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Endosome. Synapse. Note=Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions.
Protein: SIKE1_RAT
Sequence: MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGAVLPEQYQEDASDVKDMSKYKPHILLSQENTQIRDLQQENRELWVSLEEHQDALELIMSKYRKQMLQLMVAKQAVDAEPVLKAHQSHSAEIESQIDRICEMGAVMRRAVQVDDNQFCKIQEKLAQLELENKELRELLSISSESLQVGKESSVAPEAQTIR
What is the function of this protein?
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3.  Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter.  May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI.  Does not inhibit NF-kappa-B activation pathways (By similarity).
What are the official names of this protein?
Suppressor of IKBKE 1, Suppressor of IKK-epsilon.
What is the protein family that this protein belongs to?
Belongs to the SIKE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB_SHEB2
Sequence: MAEVANNEQQAPQFNIQRVYTKDVSFETPNSPAVFQKEWNPEVKLDLDTRSAKLADDVYEVVLSLTVTAQNGGDTAFLCEVQQAGIFSITGLTEPQLAHSLGAYCPNILFPYARETVGSLVGRGTFPQLNLAPVNFDALFAQYVQQRQAAATAPAAEEANA
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSEA_ECOLI
Sequence: MQKEQLSALMDGETLDSELLNELAHNPEMQKTWESYHLIRDSMRGDTPEVLHFDISSRVMAAIEEEPVRQPATLIPEAQPAPHQWQKMPFWQKVRPWAAQLTQMGVAACVSLAVIVGVQHYNGQSETSQQPETPVFNTLPMMGKASPVSLGVPSEATANNGQQQQVQEQRRRINAMLQDYELQRRLHSEQLQFEQAQTQQAAVQVPGIQTLGTQSQ
What is the function of this protein?
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE).  ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP).  RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses.  The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.  Overexpression of RseA blocks sigma-E from acting, results in cell lysis in stationary phase and temperature-sensitivity above 37 degrees Celsius.
What are the official names of this protein?
Anti-sigma-E factor RseA, Regulator of SigE, Sigma-E anti-sigma factor RseA, Sigma-E factor negative regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the RseA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Following cleavage by DegS the large fragment of the protein is still in the inner membrane and retains its anti-sigma-E activity.
Protein: BL1S2_NEMVE
Sequence: MADEESSSSSLLSKDLKLPPKTARDIGSVDIKEDEDPFGEISTDARARQRLVSEGSTTAEAEEKDLKETCRVAFDKITQYLNGELTASLEDYTLLEQLNNLTTDKYKEMSTMTKSLITTMEKLDDKYKSLQPYLEQIDRIEDSVSSLEQAAYRLDAYSKKLENKFKRLERR
What is the function of this protein?
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).  May also participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor.  May also play a role in intracellular vesicle trafficking.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit 2, BLOC-1 subunit 2.
What is the protein family that this protein belongs to?
Belongs to the BLOC1S2 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane.
Protein: YD182_YEAST
Sequence: MNKRYKLYRVWYYYAHQTVCITSTGFALCFVVQAKTAGLGVTPITSLYGDKKEHLGKLLVPLVLYQI
What are the official names of this protein?
Uncharacterized protein YDR182W-A.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: PHT14_ARATH
Sequence: MAREQLQVLNALDVAKTQWYHFTAIIIAGMGFFTDAYDLFCISLVTKLLGRIYYHVEGAQKPGTLPPNVAAAVNGVAFCGTLAGQLFFGWLGDKLGRKKVYGMTLMVMVLCSIASGLSFGHEPKAVMATLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFVSAVFAMQGFGIMAGGIFAIIISSAFEAKFPSPAYADDALGSTIPQADLVWRIILMAGAIPAAMTYYSRSKMPETARYTALVAKDAKQAASDMSKVLQVEIEPEQQKLEEISKEKSKAFGLFSKEFMSRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPPAQSMNAIQEVFKIARAQTLIALCSTVPGYWFTVAFIDVIGRFAIQMMGFFFMTVFMFALAIPYNHWTHKENRIGFVIMYSLTFFFANFGPNATTFVVPAEIFPARFRSTCHGISAASGKLGAMVGAFGFLYLAQNPDKDKTDAGYPPGIGVRNSLIVLGVVNFLGILFTFLVPESKGKSLEEMSGENEDNENSNNDSRTVPIV
What is the function of this protein?
High-affinity transporter for external inorganic phosphate.  Acts as a H(+):phosphate symporter in both low- and high-Pi conditions.  Confers sensitivity to arsenate.
What are the official names of this protein?
Inorganic phosphate transporter 1-4, AtPht1;4, H(+)/Pi cotransporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. phosphate:H(+) symporter (TC 2.A.1.9) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: UBIB_PSEMY
Sequence: MKLLAVRRLLRIQRVVIRYQLDELLLELPLPFWLRALSWLLPWRWLPRRPLALSRGARLRLALEDLGPIFIKFGQLLSTRRDLLPPDIADELARLQDQVPPFPEDQAIALIERQLGAPVSQLFARFDSQPLASASVAQVHAAQLKSGEEVVVKVVRPGLKPVIRQDLAWLFLLARIAERASADARRLRPVEVVSDYEKTIFDELDLLREAANASQLRRNFEGSPLLYVPQVYWDLCRHQVLVMERIYGVPVTDLATLADQRTDMKLLAERGVEIFFTQVFRDSFFHADMHPGNIFVSTRTPWSPQYIAIDCGIIGSLTDEDQDYLARNLIAFFKRDYRKVAQLHIDSGWVPADTKVNEFEAAIRTVCEPIFEKPLKDISFGQLLLRLFQTARRFNMEVQPQLVLLQKTLLNIEGLGRQLYPDLDLWSTAQPFLERWMRERVSPLHLLRNLQQQAEQVPHLSQIARDALERLQRPEPPRESDARDQWPLRLLGAALIAAGAVQGLAPLLATWPAWLMVGGGLYLVLRR
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.