PharMolix/UniProtQA huggingface dataset:
Protein: GNPAT_RAT
Sequence: MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRQVSDFKFAMKCYTPPLYRGITPCKPSDIKSIVLNSEEINYVIKQLSRESLTGVDVLREEANEILEEMSHKLRIGAIRFFAFVLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVILLPSHRSYIDFLMLSFVLYNYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRSGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYELLGIPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRLSRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVAILLQNQLCMDFDALVEKTLWLKGLTQVFGGFLLWPDNKLPEEVVQSSILLHSNLATLVKDQVVLKVDSESSQMVNGLVPQHIAFLMCSAYRNQLLNVFARPSLVAVALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKTEVMQMTGKDIILTDKGNAVLQFLTGLFKPFVESYQILSKCLLHEEDYFSEKEYLVTARKFTRQLLDQDASQCYDALSSELQKNALAAFVRLGVVEKNKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL
What is the function of this protein?
Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis.
What are the official names of this protein?
Dihydroxyacetone phosphate acyltransferase, DAP-AT, DHAP-AT, Acyl-CoA:dihydroxyacetonephosphateacyltransferase, Glycerone-phosphate O-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Peroxisome membrane; Peripheral membrane protein; Matrix side. Note=Exclusively localized to the lumenal side of the peroxisomal membrane.
Protein: LEUC_PSE14
Sequence: MAGKTLYDKLWDSHLVKQRDDGSALIYIDRHIIHEVTSPQAFEGLRLAKRKPWRIDSIIATPDHNVPTTSERKGGIDAIEDQVSRLQVQTLDDNCDEYGITEFKMNDPRQGIVHVIGPEQGATLPGMSVVCGDSHTSTHGAFGALAHGIGTSEVEHVLATQCLVAKKMKNMLVSVEGQLPFGVTAKDIVLAVIGKIGTAGGNGYAIEFAGSAIRDLSIEGRMTICNMSIEAGARVGMVATDEKTVEYVKGRPFAPKGAEWDLAVEAWKDLVSDADAVFDTVVRLDAAQIKPQVSWGTSPEMVLAVDQNVPDPAQEPDLVKRGSIERALKYMGLKANQPITDIQLDRVFIGSCTNSRIEDLRAAADVAKGRKVAATIKQAIVVPGSGLIKEQAEKEGLDKVFIEAGFEWREPGCSMCLAMNPDRLGSGEHCASTSNRNFEGRQGAGGRTHLVSPAMAAAAAVNGRFIDVRDLIQL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: RGS8_MOUSE
Sequence: MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
What is the function of this protein?
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2.  Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.  Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.
What are the official names of this protein?
Regulator of G-protein signaling 8, RGS8.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, dendrite. Nucleus. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1.
Protein: MENC_SALCH
Sequence: MRSAQVYRWQIPMDAGVVLRDRRLKTRDGLYVCLRDGEREGWGEISPLPGFSQETWEEAQTALLTWVNDWLQGSEGLPEMPSVAFGASCALAELTGVLPEAADYRAAPLCTGDPDDLVLRLADMPGEKIAKVKVGLYEAVRDGMVVNLLLEAIPDLHLRLDANRAWTPLKAQQFAKYVNPDYRARIAFLEEPCKTRDDSRAFARETGIAIAWDESLREADFTFEAEEGVRAVVIKPTLTGSLDKVREQVAAAHALGLTAVISSSIESSLGLTQLARIAAWLTPGTLPGLDTLHLMQAQQIRPWPGSALPCLKREELERLL
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: VEA_GIBF5
Sequence: MATPSSIPAEPKRDVVNRIHRVTRGNRSLWYQMTVLQQPERARACGSGSKANSDRRPVDPPPVVELRIIEGPSVEEGKDITFDYNANFFLYASLEHARPLARGRVNTPAAGNPPILTGVPASGMAYLDRPTEAGYFIFPDLSVRHEGLYILTFSLFETTKEERDFDLEPADGDLPPGVDYRMEIKTDPFSVYSAKKFPGLMESTQLSKTVADQGCQVRIRRDVRMRKRESKPGAGNSNSGGNGFERREEDFGRRRTITPASEDPHSIRNRSHSNSSEQRTPYTDASRRPSMVDSYPPPPPPPSYEPAPSASRHLDFGDSSAAQYPTPRQYAHQPGLQITPGPPSGSYAPTAQSPYSKTDAPYGYVNRNIPPSCPSPAPSVKHDLYDRRQSTSSYVPPSPSVYSTEGHHRRDSRPSYPPTPVAAPRPRPMHSQTSLPALKIDQLVSPVSPLPPIEPQTGPAPELPPINVGGKRKHESVFAQSTRPLHNGQRQVDPHYGRSHRGYSPDHDQGWYSRADGQISSVQFNRYYDE
What is the function of this protein?
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:20572938).  The velvet complex hat acts as a global regulator for secondary metabolite gene expression (PubMed:20572938).  Controls positively the expression of the gibberellins, fumonisins and fusarin C gene clusters (PubMed:20572938).  Controls the expression of the fusaric acid gene cluster (PubMed:24389666).  Controls negatively the expression of the bikaverin gene cluster (PubMed:20572938).  Regulates the expression of laeA (PubMed:20572938).  Plays a crucial role in virulence (PubMed:20572938).
What are the official names of this protein?
Developmental and secondary metabolism regulator VEL1, Velvet complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the velvet family. VeA subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Enriched in the nucleus in the dark (By similarity).
Protein: PURL_ANOFW
Sequence: MSLLLEPSPTMIKEQKMYRDMGLTDEEFAMIERILGRLPNYTETGIFSVMWSEHCSYKNSKPVLKKFPTEGKHVLQGPGEGAGIVDIGDGLAVAFKIESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPIALLNSLRFGELTSPRVKYLFERVVAGIAGYGNCVGIPTVGGEVQFDAAYEGNPLVNAMCVGVIRHEDIQKGIASGVGNTVMYVGAKTGRDGIHGATFASEELTEQSEQKRPAVQVGDPFMEKLLLEACLEVIHCDALVGMQDMGAAGLTSSSAEMASKAGSGIELNLDLVPQRETGMTPYEMMLSESQERMLLVVKKGREQEIMDVFSKYGLEAKAIGRVTDDHMLRLYHRGEVVAEIPVDALAKDAPVYHKPSQEPAYYREFQTMEYVPTVDNYEETLLALLSQPTIASKEWVYEQYDYMVRTNTVVAPGSDAAVLRIRGTNKALAMTTDCNSRYVYLDPEVGGKIAIAEAARNIVCSGAQPLAVTDCLNFGNPEKPEIFWQLEKAVDGMSEACRILETPVISGNVSLYNETNGEAIYPTPIVGMVGIVEHVDHITTQAFKQPGDLIYIIGEAKQEFGGSELQKWLTGRIFGKAPTIDLHVEVKRQQQLLTAIRAGVVASAHDVSEGGLAVALAECVMSAQGLGARVEMKGDVVAELFSETQSRFIVSVKKEHQQMFERLVQAVRIGEVTNDGTLHVTAEDTCILHVPVETMRNVWKGAIPCLLKSKD
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_METFK
Sequence: MPMLQNVTILGATGTIGLNTLDVISRHPGRYRVFALTANSRVDELAELCLQHRPRYAVMLDSGAAEKLQQKLKGLETQVLSGLAALEEVAAHPEAHVVMAAIVGAAGLKPAMAAAYAGKRILLANKETLVMAGKLFMQAVEEGGATLLPIDSEHNAIFQVMPPARLSALADGGIRRILLTASGGPFRKSSFAELMAVTPAQALNHPNWVMGPKITIDSATLMNKGLEVIEAHWLFNAPADKIEVVVHPQSVIHSMVEYIDGSVLAQMGNPDMRTPIAYGLGYPERLKAGVNALDLFKVGRLDFEAPDTARFPCLRLAFDALRHGGTAPAILNAANEVAVDAFLNGNIGFQDIPRLIEAVLTAMDIEAVTSISQLIEVDALARAHALEWRQLEAC
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: SYV_ZYMMO
Sequence: MTIDKTFDPAAIESRWYTHWEEEGLFHPERPGADPFTLVIPPPNVTGSLHIGHALDDTLQDILVRHARLKGKDALWVVGTDHAGIATQMVVERNLAKIGQKRTDMDRETFVNKVWEWKAESGGTITRQLRRLGASCDWAHERFTMDEGFSKAVIKVFVSLYNEGLIYRDKRLVNWDPHLGTAISDLEVENREVQGHFWHFRYPLEDGSGEIIVATTRPETMLADMAVAVNPEDDRYKALIGKNIRLPITNRLIPIIADIHADPELGSGAVKITPGHDFNDFEVGKRAGIKPADMLNMLDSHARVIQTAENDVPEELIGLDRFEARQIIVEKIDALGLLDKIEDRVIQAPYGDRSGVPIEPWLTDQWYVDAEKLAQPALEAVRSGKIKIIPESWTKTYYNWLENIQPWCISRQLWWGHQIPVWYTDDGQAIVAENEESAQEKAGQGVNLRRDPDVLDTWFSSALWPFATLGWPDTDPKALGRYPNDVLISGFDILFFWDARMIMQGLHFMKDVPFPKLYLHGLVRAADGSKMSKSKGNTVDPLGLIDKYGADALRFTLCAMESQGRDIKLDEKRVEGYRNFATKLWNAVRFAQNNNCAVNTSKQPPEATLTTNRWIIAETAKVARALDQHIEDMRYDELANSLYHFVWNDFCDWYLELIKPILTSTEDQNQGELQETLAVLGWVIDQILIMLHPIMPFITEELWHALGDRDHDLIVAAWPDYKNWSVDETAQNDIDWLIRLITAIRATRSELNVPPALKVPLHSHGIPEKAAHNLERFDPFIKRLARIESIHKEAAPKGAAAQIVVDEATFVLPLEGVIDLDAERGRLKKAIEAVEKEKTATEKRLGNPNFVARAKAEVVAENRERLNNFTGEITKLKAALERLM
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREF_BURCJ
Sequence: MTTTELVALLHLASPALPIGAYSYSQGLEAALDANLIRDADSARDWIASGLTDVLAHGELPFLAHQLARWQTDDTHALAAENAWFVASRESAELRRETEQMGWSLAQLCASLEWGDAARRATLASLSPIALPTAFAYAAAAHDASADATLAAYAFGWVENQTSAALKAVPLGQLAGQRIIVALRGAIDAAVRRALATPPDAVNTFAPQLGILSARHETQYSRLFRS
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreF.
What is the protein family that this protein belongs to?
Belongs to the UreF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UL01_PSHV1
Sequence: MEVARDGIMHPVDDFLMVVKAAMLEMMMMGKMAERYYYYVQLAFKMLVGVLKNLPVVYSYRYDAREYITETSNAVLGDDEVFEFGSSGEMVNSFLAFLRRALDWCAKFDEPPDMGGHGIEFMYPTRPTRIQRSTMGYFVRPKVPAAIVADAAVAAANLHFSNQVGEVSVRVPSRDLQPGEAGPSSSGGGRRDPAQANRGPVARVTPFVVERRYEEGEPGENGDESDEDGGRMDGDEDAAQSEQNNDDGMDYESDVTDHSSAWGEEPDRRHDAEAGERGSERSGSNSEADERRRSYENDDIQVDVTSVSEDSESDGDFEERRDARIRGATADAPRPRRGEREEDDERGEGAANDGGRRPARRDSPDSVIVIDDTSSSEDETFPPVLWLQRRDDPRTLLSRTRRAASRTRTIGGTRPRSRSPHRRGEGRDLPEDN
What are the official names of this protein?
Uncharacterized protein UL-1.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: KGUA_STRA1
Sequence: MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFDYSVSMTTRPQRPGEVDGVDYFFRTREEFEALIKEGQMLEYAEYVGNYYGTPLSYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFIFLTPPDLEELEERLVGRGTDSPEVIAQRIERAKEEIALMREYDYAVVNDQVSLAAERVKRVIEAEHYRVDRVIGRYTNMVKETDKKLS
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_NEIMA
Sequence: MSEIGLVKIYSGKVRDLYEIDDKRMLMVASDRLSAFDVILDDPIPSKGEILTQISNFWFKKLAHIMPNHFTGQTVYDVLPENEAKVLEKRAVVAKKLTPVKVEAIVRGYLAGSGWKDYQKTGSVCGIRLPEGMQEAQQLPEVIFTPSTKAAVGDHDENISFEECGRIIGKELAEEVRAKAVRLYTEAAEYAKSRGIIICDTKFEFGLDTNGTLTLMDEVLTPDSSRFWPADQYEVGTNPPSFDKQFVRDWLEQSGWNKKAPAPKVPADVIQKTVEKYREALTLLTQD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: TCX3_ARATH
Sequence: MDTPEKSETQIGTPVSKLKVEDSPVFSYICNLSPIKTIKPIPITCPLSSLNYASPPSVFTSPHAVSHKESRFRSQKDVSASKEVGEEEALVGSEPEQSYKNDCNTPRVTNDVKDNGCGKDLQVMMDNVKKKSDTPDWETLIAATTELIYGSPRESEAFSCLLKKTSNSEARLRGSITATSVAVTNTDVVNNESESVDALSILHRGVRRRCLDFEVKGNNQQTLGESSSSCVVPSIGLHLNTIAMSSKDKNVANEYSFSGNIKVGVQSSLTPVLHSQHDIVRENESGKDSGQIIEVVPKSLASVDLTPISPKKKRRKSEQSGEGDSSCKRCNCKKSKCLKLYCECFAAGFYCIEPCSCINCFNKPIHKDVVLATRKQIESRNPLAFAPKVIRNSDSIIEVGEDASKTPASARHKRGCNCKKSNCLKKYCECYQGGVGCSINCRCEGCKNAFGRKDGSLFEQDEENETSGTPGTKKTQQNVELFKPAAPPSTPIPFRQPLAQLPISSNNRLLPPQSHFHHGAIGSSSSGIYNIRKPDMSLLSHSRIETITEDIDDMSENLIHSPITTLSPNSKRVSLSHLDSPESTPWRRNGGGRNLIRSFPTFPSLTPHH
What is the function of this protein?
Plays a role in development of both male and female reproductive tissues.
What are the official names of this protein?
Protein tesmin/TSO1-like CXC 3, AtTCX3, Protein TSO1-like 1, Protein SOL1.
What is the protein family that this protein belongs to?
Belongs to the lin-54 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS7_DINSH
Sequence: MSRRHAAEKREVLPDAKFGDRVLTKFMNNLMIDGKKSAAEKIVYNAFDRVESKLKRSPLEVFHECLDNIKPSVEVRSRRVGGATYQVPVEVRPERREALAIRWLINASRARNENTMEERLAGELVDAVNSRGSAVKKREDTHKMAEANKAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: GON2_HYDCO
Sequence: QHWSHGWYPG
What is the function of this protein?
Stimulates the secretion of gonadotropins.
What are the official names of this protein?
Gonadoliberin-2, Gonadoliberin II, Gonadotropin-releasing hormone II, GnRH-II, Luliberin II, Luteinizing hormone-releasing hormone II, LH-RH II.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPA_CERS1
Sequence: MTRIDDTFRRLRAEGKKAFVAYIMAGDPDLETSLAVMRGLPEAGVDIIELGMPFTDPMADGPTIQTAGQRALEGGQTLTRTLEMVRAFRAENAETPIVMMGYYNPIYARGVETFLAEATEAGIDGLIVVDLPPEEDAELCLPAQAAGLNFIRLATPTTDSRRLPKVLQNTSGFVYYVSITGITGAAAAQAADVAPEVARIKAATDLPVIVGFGITTPEAAQDLAGIADGCVVGSAIVKLVGEGRPVAEVLDRVAALAAGAHAA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: RPOE_STRA5
Sequence: MELEVFAGQEKSELSMIEVARAILEQRGRDNEMYFSDLVNDIQTYLGKSDSAIRESLPFFYSDLNTDGSFIPLGENKWGLRSWYAIDEIDEEIITLEEDEDGAPKRKKKRVNAFMDGDEDAIDYNDDDPEDEDFTEETPSLEYDEENPDDEKSEVESYDSEINEIIPDEDLDEDVEINEEDDEEEEEEEEV
What is the function of this protein?
Participates in both the initiation and recycling phases of transcription.  In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.
What are the official names of this protein?
Probable DNA-directed RNA polymerase subunit delta, RNAP delta factor.
What is the protein family that this protein belongs to?
Belongs to the RpoE family.
Protein: MANB_DICDI
Sequence: MGKVLILFLFVLLLITFINCTNNKILNNENSSNEDNVINVFLIPHSHCDLGWVQTLEEYYSENVTVILDNVINTLIKDSSKKFNWAEIYYFETWWNEQSSFLQAQVRNLVNNGQLYFVGGGWAQNDEGATHYQAVINQMTLGHQFLLSEFGVVPEIGWQIDPFGPSTLTATLFSLMGFKYHVINRIDERIKYIYNDTPDIVGSGWMTTDRSFEFQWYPSHNDQELSIFTHVLDHHYNSPYLIYPNASNPNQSLTTGFDFESDPTQNPPINQSNIYERAAVFVEIMQQRSQLYRHNNLLIPFGNDFRFQNASLEFDNMDKLITYINSNSSWGVTIQYATLNEYFEKVESIEPPVEYADIVGQDLFVYTMCLASDYQAFNTCANWWSGYYTSYPLLKQTARDSDSLLRVGEMLYSLSCFYSNGFDFDFNIGFYALSMHRNVSGILTHHDAITGTAKEYVRVNYFQMLNEAQSLTLDYNIPDFVGFLLSNKSLNIDYQSNGSSILNSTNPGDIIAISFTNSIAWDRIETVSIEIPFVNMAVYDYQLNPIQSQIVQRFDKSNNWYLYFQVATPALGISTYFIVILSTDGEILNDNSKNLPTPIQSILSISNELLFNDNDDETTTTTIGNSNFNLNFKFDRDNNNLLTLNSYDDLFNNKIGIPISQHLIEYTSLSDDAYKFRVQGLPIPLTPINPQFYLTIGPVVQIVTIIYNNNCSQSYLIYNDTTSFNPFETDNDNNNNSRLIKNDQYFEIDNIVASGWDKEISMKFTTNINNQNIFYTNNGLEIMKRQWEIHWNDTFIWSEITSNFYPMINTGYIVDQQVSDYQQQLTILSKQTFGASSQTNGEFEVLLIRRSNYTQWSVHEPMNDTSNPSLRVLCIFGDPNFSNEIRTPHSILFENPLQPVYSLIPNSIPIEKYIDTYNTLFKPLQTSLPYNLHLLTFTKQWIDSPSIIMRLINIYEIGQSINFSKSINFNIGSGDNNNNNNNNNNNGFLTHYNISQIIETTLSANSELSNPTNNLVITLEPLEIKTFLLTLSPKQ
What are the official names of this protein?
Alpha-mannosidase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 38 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HH_DROSI
Sequence: MDNHSSVPWASAASVTCLSLDAKCHSSSSSCSSKSTASSISASPETQTMRHIAHTQRCLSRLTSLVALLLIVLPMMFSPAHSCGPGRGLGRHRARNLYPLVLKQTIPNLSEYTNSASGPLEGVIRRDSPKFKDLVPNYNRDILFRDEEGTGADRLMSKRCKEKLNVLAYSVMNEWPGIRLLVTESWDEDYHHGQESLHYEGRAVTIATSDRDQSKYGMLARLAVEAGFDWVSYVSRRHIYCSVKSDSSISSHVHGCFTPESTALLESGVRKPLGELSIGDRVLSMTANGQGVYSEVILFMDRNLEQMQNFVQLHTDGGAVLTVTPAHLVSVWQPESQKLTFVFADRIEESTFFLLRDGQSGGGGEKQVQQNGIHWYANALYKVKDYVLPQSWRHD
What is the function of this protein?
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.  Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks.  Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc.  In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu).  Essential component of a signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection.  During photoreceptor differentiation, it up-regulates transcription of Ubr3, which in turn promotes the hh-signaling pathway by mediating the ubiquitination and degradation of cos.
What are the official names of this protein?
Protein hedgehog.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear up to embryonic stage 10 and then at stage 11 shifts to the cytoplasm. Also secreted in either cleaved or uncleaved form to mediate signaling to other cells. SUBCELLULAR LOCATION: [Protein hedgehog N-product]: Cell membrane; Lipid-anchor. Note=The N-terminal peptide remains associated with the cell surface. Heparan sulfate proteoglycans of the extracellular matrix play an essential role in diffusion. Lipophorin is required for diffusion, probably by acting as vehicle for its movement, explaining how it can spread over long distances despite its lipidation.
Protein: SIG15_HUMAN
Sequence: MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRWSMQVPPEVSAEAGDAAVLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNPRRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNISVLPSPAHAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAANSLGRSEASVYLFRFHGASGASTVALLLGALGFKALLLLGVLAARAARRRPEHLDTPDTPPRSQAQESNYENLSQMNPRSPPATMCSP
What is the function of this protein?
Binds sialylated glycoproteins.
What are the official names of this protein?
Sialic acid-binding Ig-like lectin 15, Siglec-15, CD33 antigen-like 3.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PLSY_DESAP
Sequence: MSALAVILVIGLSYLVGSVPTGYLIARHVKGIDIRGHGSGNIGATNVWRTLGPGWGLASLVGDTAKGIVAVLLGRAVGVPGLELLTGAAALTGHGWSVFLRFQGGKIIATSLGVLIMLPPVALATAAAVWIAVLALTRYVSLASIIAASSVPLAFALGGVGWRHVLFGLFLALVAVYKHRANIDRLLKGKESRFSFRK
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNAJ_POLNA
Sequence: MAKKDYYDTLGVPKNASDEDIKKAYRKLAMKHHPDRNQGDTSKVSEDKFKEAKEAYEMLSDAQKRAAYDQYGHAGVDPNRGGGPGAEGFGGFAEAFGDIFGDVFGGQRGGAQGGGGRQVYRGGDLSYAMEVTLEEAAAGKEAQIRIPSWDDCGICHGTGAKPGTKVATCTTCHGHGVVQMRQGFFSVQQTCPQCKGSGKLIPSPCVACHGVGKTKNNKTLEVKIPAGIDDGMRIRSTGNGEPGTNGGPPGDLYIEIRLKKHDIFERDGDDLHCSMPISFMTAALGGEIEVPTLAGKAAIDIPEGTQAGKQFRLRGKGIKGVRSSYPGDLYCHITVETPVKLTEHQRKLLKELDESIKKGGAKHSPSEEGWTDKLKNFFGA
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWAHC_MOUSE
Sequence: MEGSLELSSEAILRFLAERGGRAGHSELVQHFRDVLGGQREQRTRARERFKELVNAVATVRTDPADGTKYVHLKKRFCTGDSPPLEAKLPREPPRIEVTEEPQVPDLAAEPCEGSQLQEANPQLSLGLGGEVSDQEPPAPAQGGAQGKDSPPQEVEAVSWASGPGSSENLKLPPQGEAEGGSSPSGPNTPRSARQNFRDLVLGSSPQLKRSVGPGDGNAGGRSRGGGDSDTASLASSSAEEESSVGASVTLDPLDHAWMLSASEGKWDSLEGLLTCEPGLLSKRDFITGFTCLHWAAKHGRQELLAMLVNFATKHQLPVNINAKSSGGYTALHLAAMHGHVEVVKLLVGAYDADVDIRDYSGRKASQYLSESIAEEIKNLVGALDEDDGDSPAARGGGRWRLSKVLPSHITHKLSPVVEDGAELHHHVPEGWTGGSKAKDSGRKASGSSSGRMKPRLNKIRFRTQIIHTTPSFRDAKPTLEEGEEEEEEEEERSLRGYSSSFKLRPKSNVFG
What are the official names of this protein?
Ankyrin repeat domain-containing protein SOWAHC, Ankyrin repeat domain-containing protein 57, Protein sosondowah homolog C.
What is the protein family that this protein belongs to?
Belongs to the SOWAH family.
Protein: VNS3_BMDNV
Sequence: MLRICSGVDRVDRDCLILPWIDVKAPPEAPAFIIVPSAGVKYVEMALGWFFKLFFFVSTPFDVVIDFLFRVVFICLELDGRFLRFSSSLSDSDWLDCWLSAVSVSSRYDSEIVVGWVSSTNVLWVVFRSFICFMEPNSVRTSAIKSSPLFVNHFTKSVAWSKLNGVV
What are the official names of this protein?
Putative non-structural protein, ORF3.