PharMolix/UniProtQA huggingface dataset:
Protein: APOE_DINBR
Sequence: MKVLWAVLVVTLLAGCQADVEPELEAQEPAVWQNGQPWELALGRFWDYLRWVQTLSDQVQEELLSSQVTQELTVLMEDTMKEVKAYKSELEQELAPMAEETKARLSKELKAAQARLGADMEEVRNRLSQYRGEVQSMLGHSAEELRARLATHLRKLRKRLLRDAEDLQKRLAVYKAGASEGAERSVSAIRERLGSLVEQGRLRTAALTSQPLQERAQAWGERLRGRLEEVGSKARDRLDEVREQMEEVRLKVEEQAEAFQARLKGWFEPMMEDIRRQWADLIEKMQAAVGTSTPAPTQKP
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL receptor-related proteins LRP1, LRP2 and LRP8 and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.  A main function of APOE is to mediate lipoprotein clearance through the uptake of chylomicrons, VLDLs, and HDLs by hepatocytes.  APOE is also involved in the biosynthesis by the liver of VLDLs as well as their uptake by peripheral tissues ensuring the delivery of triglycerides and energy storage in muscle, heart and adipose tissues.  By participating in the lipoprotein-mediated distribution of lipids among tissues, APOE plays a critical role in plasma and tissues lipid homeostasis.  APOE is also involved in two steps of reverse cholesterol transport, the HDLs-mediated transport of cholesterol from peripheral tissues to the liver, and thereby plays an important role in cholesterol homeostasis.  First, it is functionally associated with ABCA1 in the biogenesis of HDLs in tissues.  Second, it is enriched in circulating HDLs and mediates their uptake by hepatocytes.  APOE also plays an important role in lipid transport in the central nervous system, regulating neuron survival and sprouting.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: CAST1_PONAB
Sequence: MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPEDYTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSHSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVTRDDFSNGFPRTQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHRTPKEAASSSPEPSSITFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRRQEGLAS
What is the function of this protein?
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway.  As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1.  Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
What are the official names of this protein?
Cytosolic arginine sensor for mTORC1 subunit 1, GATS-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the GATS family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: RK22_NYMAL
Sequence: MIKKTSGTEIRALARHIGMSAQKARRVIDQIRGCSYEQTLMILELMPYRACYPIFKLVYSAAANASHNRGLKEADLFISKAEVNEGVIVKRLKPRARGRSYPIKRPTCHITIVLSERPNFNFKNI
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: COX2_SCHGR
Sequence: MATWSNLSIQDGASPLMEQLSFFHDDHTMVVLLITVIVGYALSYMLFNAYTNRNMLHGHLIETIWTALPAITLIFIALPSLRLLYLLDDSVDAMITIKTIGRQWYWSYEYSDFMDVEFDTYMTPEQDLENDGFRLLDVDNRTILPMNTEVRVLTSASDVLHSWAVPALGVKIDATPGRLNQGTFTMNRPGLFFGQCSEICGANHSFMPIVIESTSVNLFIKWLSKMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PRSA_STRP2
Sequence: MKKKLLAGAITLLSVATLAACSKGSEGADLISMKGDVITEHQFYEQVKNNPSAQQVLLNMTIQKVFEKQYGSELDDKEVDDTIAEEKKQYGENYQRVLSQAGMTLETRKAQIRTSKLVELAVKKVAEAELTDEAYKKAFDEYTPDVTAQIIRLNNEDKAKEVLEKAKAEGADFAQLAKDNSTDEKTKENGGEITFDSASTEVPEQVKKAAFALDVDGVSDVITATGTQAYSSQYYIVKLTKKTEKSSNIDDYKEKLKTVILTQKQNDSTFVQSIIGKELQAANIKVKDQAFQNIFTQYIGGGDSSSSSSTSNE
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: PPI1_STAS1
Sequence: MTNYPQLNTEINGNEIKLIMHTNKGDMTFKLLPDVAPKTVENFVTHAKNGYYNGVTFHRVINDFMVQGGDPTATGMGGESIYGEPFEDEFSKEAFNIYGALSMANAGPHTNGSQFFIVQMNEVPESMLSQLADGGWPEPIVKAYAETGGTPWLDQKHTVFGQLIEGKDTLEDIANTKVGPQDKPLHDITIDSIEIVE
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
Putative peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
Protein: MCPAL_ARTOC
Sequence: MQPLLVLATLLGSALAGTIPLQSANYHGYKVVRLSGEDTSKISHIVSQLGLETWKFPKSANANVDIVVPPKKIAEFEKMSHAAGLKKQIMHEDLGRSIASEMSFRPYSYGGANDTWFQSYHKYEDHLKFMKDFQSAHAENTEIVTSGKSHEGRDITGVHVWGSGGKGSKPAVVFHGTVHAREWITTMTVEYILNQLLEDKEAGAALLDKYDFYIFPITNPDGFVFSTDHDRMWRKNREQNEKGCYGTDLNRNWPYEWDGDGSTTDPCSETYRGPSPGSAPETKASTSFIKGLADGAGVKMFVDWHSYSQLFMTPYGYSCSARAPNDDVLQEMASSFADAVKAVHGTSFTTGPICSTIYQANGNSVDWVVDEIKGETAFAAELRDTGMHGFVLPPDQIIPSGEETWAGVKAMFSKLK
What is the function of this protein?
Extracellular metalloprotease that contributes to pathogenicity.
What are the official names of this protein?
Metallocarboxypeptidase A-like protein MCYG_01475.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
What are the subcellular locations of this protein?
Secreted.
Protein: MSP1_MYCSO
Sequence: MKLFSASVFAAIIASHYASATAHIRAPNVKPRRTNSLLTAPPQQPPLPSAQQAASASSSAGLNLTDIQGDILIGMKKNKELFFFFSITDAATFKAKLGSDILELITSTNQLLAVATQPITAVNVAFSSTGLKALGITDDLKDPVFEAGMLSNAVSDLSDPGTGNWVPGFVGTSVHGVFLLASDTIDNVNTELANIQTILNGSITEIHRLQGEARPGDQQGHEHFGFMDGISNPAVDGFTPPAEIRPGQALIPPGIMLLGEANDTFQNDRPPWAKDGSFLVFRQMQQRAPEFNKFLQDHALNMPNMTSEQGADLLGARIVGRWKSDAPIDLTPLVDDPVLAADNQRNNNFDFSDATNQTRCPFSAHIRKANPRGDLGGINKFPNQHIIRAGIPYGPEVTDAEKASNSSSTDPSLERGLAFVAYQSNIQNGFVFLQKNWVDNTNFFRPGTGVDPLIGTNSRNSGTDAPNTPRVVSGLDPNNATSTIEIGIDFVVSRGGEYFFSPSLSAIRTVLSV
What is the function of this protein?
Manganese-independent peroxidase that is able to convert a large number of compounds, but its physiological substrate is not known (PubMed:23111597).  In addition to classic peroxidase substrates (e. g.  2,6-dimethoxyphenol), oxidizes dyes such as Reactive Blue 5 (PubMed:23111597).  Also degrades beta-carotene (PubMed:18038130).
What are the official names of this protein?
Dye-decolorizing peroxidase msp1, Peroxidase 1, MsP1.
What is the protein family that this protein belongs to?
Belongs to the DyP-type peroxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: DCNL3_XENTR
Sequence: MGQCVTKCKNPSSTLGSKNGERESSKPHKRSSSHKDEHLSICGKASREILVNGTKKGDVSLEASQPLAAGGDTKKKEQGTGAELSSVQRIEELFWRYKDEREDAILEEGMERFCNDLYVDPTEFRVLVLAWKFQAATMCKFTRREFFEGCKAINADGIEGICARFPSLLNEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNKPLILDQWLDFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKNEEETKCIPCSGTDDQSTEGQT
What is the function of this protein?
Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes.  At the cell membrane, can promote and as well inhibit cullins neddylation.
What are the official names of this protein?
DCN1-like protein 3, DCNL3, DCUN1 domain-containing protein 3, Defective in cullin neddylation protein 1-like protein 3.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
Protein: CL12A_HUMAN
Sequence: MSEEVTYADLQFQNSSEMEKIPEIGKFGEKAPPAPSHVWRPAALFLTLLCLLLLIGLGVLASMFHVTLKIEMKKMNKLQNISEELQRNISLQLMSNMNISNKIRNLSTTLQTIATKLCRELYSKEQEHKCKPCPRRWIWHKDSCYFLSDDVQTWQESKMACAAQNASLLKINNKNALEFIKSQSRSYDYWLGLSPEEDSTRGMRVDNIINSSAWVIRNAPDLNNMYCGYINRLYVQYYHCTYKKRMICEKMANPVQLGSTYFREA
What is the function of this protein?
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
What are the official names of this protein?
C-type lectin domain family 12 member A, C-type lectin-like molecule 1, CLL-1, Dendritic cell-associated lectin 2, DCAL-2, Myeloid inhibitory C-type lectin-like receptor, MICL.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization.
Protein: MTFA_ESCFE
Sequence: MIKWPWKTNDAGRNMALPWDEALAIPVLANLQPDEQSKLVQLADRFLQQKRLVPLQGFELDPLKNARIALLFCLPVLELGIEWLDGFHEVLIYPAPFVVDDEWQDDFGLVHNQRVVQSGQSWQQGPIILNWLDIQDSFDASGFNLIIHEVAHKLDTRNGDRASGVPLIPLREVAGWEHDLHAAMDNIQDEIDLVGESAASIDAYAATDPAECFAVLSEYFFSAPELFAPRFPALWQRFCQFYQQDPLLRLRQNEDPAGNSSHQLH
What is the function of this protein?
Involved in the regulation of ptsG expression by binding and inactivating Mlc.
What are the official names of this protein?
Protein MtfA, Mlc titration factor A.
What is the protein family that this protein belongs to?
Belongs to the MtfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_GEOKA
Sequence: MNFETVIGLEVHVELKTKSKIFSSSPNAFGAPPNTQTNVIDLGYPGVLPVLNRQAVEFAMKAAMALNCEIATETKFDRKNYFYPDNPKAYQISQYDQPLGRNGWIEIEVNGKKKKIGITRIHLEEDAGKLTHTGDGYSLVDFNRQGTPLIEIVSEPDIRSPEEAYAYLEKLKAIIQYTGVSDCKMEEGSLRCDANISLRPLGSDKFGTKTELKNLNSFNFVRMGLEYEAKRQEKILLSGGVIRQETRRFDEATKTTVLMRVKEGSEDYRYFPEPDLVMLYIDDEWKERVRASIPELPDARRKRYIEEWGLPEYDAKVLTLTKEMADFFEATVANGADPKLASNWLMVEVSGYLNAEQKELHDIALTPESLAGMIKLIQNGTISSKIAKKVFKELVEHGGDPEKIVKEKGLVQISDEGALRKIVLEVLDANPQSVEDYKNGKDRALGFLVGQVMKATKGQANPPLVNKLLVEEIGKR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: CATK_HUMAN
Sequence: MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
What is the function of this protein?
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling.  Displays potent endoprotease activity against fibrinogen at acid pH.  May play an important role in extracellular matrix degradation.  Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
What are the official names of this protein?
Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Protein: RIMM_STRSV
Sequence: MNYFNVGKIVNTQGLQGEMRVLSVTDFAEERFKKGNKLALFDKKDQFVMDVEIASHRKAKNFDIIKFKGMYHINDIEKFRDFSLKVAEEDLADLEDGEFYYHEIIGLEVYENDVLLGTIKEILQPGANDVWVVKRKGKRDLLLPYIPPVVLGINIEQGRVDVEIPEGLDDEN
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STRBP_CHICK
Sequence: MRSIRSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKHVSDWMDEKNKSVKCEGDVEAKEEAAESNAKDQSGRTLCGVMRIGLVAKGLLIKDDMDLELVLMCKEKPTKTLLCIVKDNLPIQIQKLTEEKYLVEEHVNEAAIIIRNTKEPKLTLKVILTSPLIRDEAEKKEGDSVAMKDPPDLLDRQKCLEALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPLELICEKSIGTCNRPLGAGEALRRVMECLASGILLPGGPGLHDPCEREPTDALSDMTVQQKEAITHSAQHALRLSAFGQIYKVLEMDPLPSNKSFQKYSWSVADKEGTGSSALKRPFEDGVGDDKDPNKKMKRNLRKILDSKAIDLMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTTYEASGPSKKTAKLHVAVKVLQAMGYPTGFDADVECVSSDEKSDNEGKNETVSSISSNNTGNSTADTSATLEVRTQGPILTASGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFRGAGPNKKVAKASAALAALEKLFSGPNAANNKKKKILPQQTKGVVNTAVSAAVQAVRGRGRGALTRGAFVGAAAATGYITPGYGAPYGYSTAAPAYGLPKRMVLLPVMKFPTYPVPHYSFF
What is the function of this protein?
May be involved in normal spermatogenesis and sperm function.  Binds to double-stranded DNA and RNA (By similarity).
What are the official names of this protein?
Spermatid perinuclear RNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_ELUMP
Sequence: MLDIKLFANDLEGVKKSLASRNPALLTLVGEITELNKTYKELLTSVENMRAKRNELSKSVGILKQKDPAAAEEAMKEVSLIKTGMSEKENMLEEIKKKISNTMLNIPNMPDPSVTIGKDEKDNKEIRKDGAAPSFSFKPLDHHAVGEKLGILDFETAAVLSGSRFALLKGDGARLERALISYMLDKHAKKGYTEVVPPSIVNEEILIGTGQLPKFREDMYALEGEPKQFLISTAEIPLTNMNRGKVLQEAELPVKLTAGTPCFRKEAGTYGKDTRGLIRNHQFDKVELVMISNSNDSFNLLEAMTADAEDVLKGLGLAYRTVELCTGDMGFSSAKTYDIEVWMPSENKYREISSCSNCTSFQARRMNLRYKNAEGKIEFVHTLNGSGVAVGRALAAILENYQQEDGSVIVPEALRPYFGKDIIK
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CE024_HUMAN
Sequence: MMHPVASSNPAFCGPGKPSCLNEDAMRAADQFDIYSSQQSKYSHTVNHKPMVCQRQDPLNETHLQTTSGRSIEIKDELKKKKNLNRSGKRGRPSGTTKSAGYRTSTGRPLGTTKAAGFKTSPGRPLGTTKAAGYKVSPGRPPGSIKALSRLADLGYGCGTAAFPYPMMHGRAVHGVEETSSEVKPPNE
What are the official names of this protein?
UPF0461 protein C5orf24.
What is the protein family that this protein belongs to?
Belongs to the UPF0461 family.
Protein: HISZ_PSEU2
Sequence: MATVDRWLLPDGIEEVLPPEAARIEVARRQVLDLFQSWGYEFVVTPHIEYLESLLTGAGSDLDLRTFKVIDPQSGRQMGFRADITPQVARIDAHTLKREGPSRLCYAGSVLHAQPRALSSSRSPIQLGAELYGDASPSSDVEVISLMLAMLQLADVPDVHMDLGHVGIYRGLARAAGLSGEVEQQLFDALQRKAIDEVIALTADLPQELATMLRALVDLCGGREVLDAARDRLAGAPAPVLAALDDLLSIAERLAARFPQLPLYFDLGELRGYHYHTGVVFAVFVPGVGQSIAQGGRYDDIGADFGRARPATGFSTDLKTLVTLGQAEIVLPSGGIWVPDSTDAALWQMVCQLRSEGQRVVQALPGQQASAAREADCDRQLIQHGEHWQVMPLAS
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSF3R_MOUSE
Sequence: MVGLGACTLTGVTLIFLLLPRSLESCGHIEISPPVVRLGDPVLASCTISPNCSKLDQQAKILWRLQDEPIQPGDRQHHLPDGTQESLITLPHLNYTQAFLFCLVPWEDSVQLLDQAELHAGYPPASPSNLSCLMHLTTNSLVCQWEPGPETHLPTSFILKSFRSRADCQYQGDTIPDCVAKKRQNNCSIPRKNLLLYQYMAIWVQAENMLGSSESPKLCLDPMDVVKLEPPMLQALDIGPDVVSHQPGCLWLSWKPWKPSEYMEQECELRYQPQLKGANWTLVFHLPSSKDQFELCGLHQAPVYTLQMRCIRSSLPGFWSPWSPGLQLRPTMKAPTIRLDTWCQKKQLDPGTVSVQLFWKPTPLQEDSGQIQGYLLSWSSPDHQGQDIHLCNTTQLSCIFLLPSEAQNVTLVAYNKAGTSSPTTVVFLENEGPAVTGLHAMAQDLNTIWVDWEAPSLLPQGYLIEWEMSSPSYNNSYKSWMIEPNGNITGILLKDNINPFQLYRITVAPLYPGIVGPPVNVYTFAGERAPPHAPALHLKHVGTTWAQLEWVPEAPRLGMIPLTHYTIFWADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRAGSTNSTGLTLRTLDPSDLNIFLGILCLVLLSTTCVVTWLCCKRRGKTSFWSDVPDPAHSSLSSWLPTIMTEETFQLPSFWDSSVPSITKITELEEDKKPTHWDSESSGNGSLPALVQAYVLQGDPREISNQSQPPSRTGDQVLYGQVLESPTSPGVMQYIRSDSTQPLLGGPTPSPKSYENIWFHSRPQETFVPQPPNQEDDCVFGPPFDFPLFQGLQVHGVEEQGGF
What is the function of this protein?
Receptor for granulocyte colony-stimulating factor (CSF3).  In addition it may function in some adhesion or recognition events at the cell surface.
What are the official names of this protein?
Granulocyte colony-stimulating factor receptor, G-CSF receptor, G-CSF-R.
What is the protein family that this protein belongs to?
Belongs to the type I cytokine receptor family. Type 2 subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GLYC_WWAVU
Sequence: MGQLISFFGEIPSIIHEALNIALIAVSIISILKGVINIWGSGLLQFIVFLLLAGRSCSYKIGHHVELQHIILNASYITPYVPMPCMINDTHFLLRGPFEASWAIKLEITDVTTLVVDTDNVANPTNISKCFANNQDERLLGFTMEWFLSGLEHDHHFTPQIICGNVSKGEVNAQVNITMEDHCSQVFLKMRRIFGVFKNPCTSHGKQNVLISVSNWTNQCSGNHLSSMHLIVQNAYKQMIKSRTLKSFFAWSLSDATGTDMPGGYCLEKWMLISSELKCFGNTAIAKCNLDHSSEFCDMLKLFEFNRNAIKTLQNDSKHQLDMIITAVNSLISDNTLMKNRLKELINIPYCNYTKFWYVNHTGFNVHSLPRCWLTKNGSYLNVSDFRNQWLLESDHLISEILSREYEARQGKTPLGLVDVCFWSTLFYVSSIFLHLLRIPTHRHIIGEGCPKPHRLSSNSVCACGLFKQKGRPLRWAGKV
What is the function of this protein?
Forms the virion spikes together with glycoprotein G1.  The glycoprotein spike trimers are connected to the underlying matrix.  Class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm.  Membrane fusion is mediated by irreversible conformational changes induced by acidification.
What are the official names of this protein?
Pre-glycoprotein polyprotein GP complex, Pre-GP-C.
What is the protein family that this protein belongs to?
Belongs to the arenaviridae GPC protein family.
What are the subcellular locations of this protein?
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. SUBCELLULAR LOCATION: [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein. Note=Binding to the stable signal peptide masks endogenous ER localization signals in the cytoplasmic domain of G2 to ensure that only the fully assembled, tripartite GP complex is transported for virion assembly. SUBCELLULAR LOCATION: [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Protein: RL23_PYRFU
Sequence: MDPYKVIIRPVVTEKAISLIEKENKLTFIVDRRATKQDIKRAVEEIFNVKVEKVNTLITPRGEKKAYVKLKPEYSASEVAARLGLF
What is the function of this protein?
Binds to 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
What are the official names of this protein?
50S ribosomal protein L23, Large ribosomal subunit protein uL23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RSSA_BOTFB
Sequence: MAPSQLPAIFNPTSQDIEQLLAAQCHLGAKNLQVHMEPYLWKTRPDGINVINIGKTWEKIVLAARIIAAIDNPADICVISARPYGQRAVLKFAAHTGAVAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHSIGLVWWMLAREVLRLRGSIASREAEWDTMVDLYFYRDPEAEENKEAIEEAKAPGADEVGAAAVDQGFAGAGDWEVSGATAGAFTAASNTAAAGGASWDAAEPSDWAAAPAAAGQEWAASGTEQW
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
What are the official names of this protein?
40S ribosomal protein S0.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cytoplasm.