PharMolix/UniProtQA huggingface dataset:
Protein: HFQ_BACLD
Sequence: MKSINIQDQFLNQIRKENTFVTVFLLNGFQLRGQVKGFDNFTVLIESEGKQQLIYKHAISTFAPQKNVQLELE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: CYSA_BRUME
Sequence: MEVRVAGVRKEFARFPALHNVSLTIQSGELIALLGPSGSGKTTLLRLIAGLETPTEGMIFFGDEDASQKSVQERNVGFVFQHYALFRHMTVADNIGFGLKVRPGGTRPSTAEIRRRALELLDLVQLSGLEKRYPAQLSGGQRQRVALARAMAIEPRVLLLDEPFGALDAQVRKELRRWLREIHDKTGHTTVFVTHDQDEALELADRVVVMSQGRIEQVGTPDEVYDKPNSPFVYGFIGESSTLPVRVENGEVWLADRNIGLGAENMPDGDAQLYFRPHDVELLDGCGGCIAGTVIASRRSGGKRRVELEVGGARERIEIEIPAEHPAAEKSRIAFRPRYWTLFRAGDSELPAPKAAATT
What is the function of this protein?
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Sulfate/thiosulfate import ATP-binding protein CysA, Sulfate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YPEP_BACSU
Sequence: MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMKELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGGTRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSWPCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLDRNGDDDIG
What are the official names of this protein?
Uncharacterized protein YpeP.
Protein: GPC1_MOUSE
Sequence: MELRTRGWWLLCAAAALVVCARGDPASKSRSCSEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANHSRMELESALHDSSRALQATLATQLHGIDDHFQRLLNDSERTLQEAFPGAFGDLYTQNTRAFRDLYAELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLPDDYLDCLGKQAEALRPFGDAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLAPECSRAIMKLVYCAHCRGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGPSGAESVIGGVHVWLAEAINALQDNKDTLTAKVIQACGNPKVNPHGSGPEEKRRRGKLALQEKPSTGTLEKLVSEAKAQLRDIQDFWISLPGTLCSEKMAMSPASDDRCWNGISKGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRGAYGGNDVDFQDASDDGSGSGSGGGCPDDTCGRRVSKKSSSSRTPLTHALPGLSEQEGQKTSAATCPEPHSFFLLFLVTLVLAAARPRWR
What is the function of this protein?
Cell surface proteoglycan that bears heparan sulfate.  Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity).  May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction.  Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.  Binds Cu(2+) or Zn(2+) ions.
What are the official names of this protein?
Glypican-1.
What is the protein family that this protein belongs to?
Belongs to the glypican family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains. SUBCELLULAR LOCATION: [Secreted glypican-1]: Secreted, extracellular space.
Protein: RL7_HAEIG
Sequence: MSLTNEQIIEAIASKTVTEIVELIAAMEEKFGVSAAAAVAAAPAAGGAAAAEEKTEFDVVLKSAGANKVAVIKAVRGATGLGLKEAKDLVESAPANLKEGVSKEEAEALKKELEEAGAEVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: RR2_THAPS
Sequence: MADINLAQLLDAGVHFGHKAYRWNPKMFPYIYTERNNIHILDLVQTAQLLKRANAYVQNAASEGKTFLFVGTKRQASAVIAQEAKRCPSGYYVNHRWLGGMLTNWVTLKSRIERLKTLEQQEVEGVFNLLPKKEASLRAKELEKLRKHLNGVKDMSKLPDVAIIIDQKREMTAIQECRKLGIPVISILDTNCDPDLVDIPIPGNDDAVRSIKLILNSLTNSIVQGCQ
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TAL_AGARV
Sequence: MKFFVDTANVEDIKKANDMGVICGVTTNPSLIAKEGRDFNEVIKEITSIVDGPISGEVKATTVDAEGMIKEGREIAAIHPNMVVKIPMTVEGLKAVKVLSSEGIKTNVTLIFSANQAILAANAGATYVSPFLGRLDDISQPGIELIRQISEIFDIYGYDTEIIAASIRNPIHVTDCALAGADIATIPYKVIEQMTKHPLTDQGIEKFQADYRAVFGD
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 3B subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YAEC_SCHPO
Sequence: MNRLNPFSKSHSKNSNENNEVSLADVAESDTRRHWLGLTKREFKLMGFAGAGFFLDSYDLFIINLVSPIYEYLYWGGLEGKKPHYPSGIHGLVNAAANIGNVFGQILFGFMGDFFGRKFVYGKEMIVVIIATVLVIALPKSIPTPLGKMMWIFAWRWLLGLGIGGDYPMSATITSERSLLSRRGTLLSIVFSFQGFGTLAGAIVTIILLACFEKPLNQRGEYTKLEGVWRLQMGLALVPALLVLIPRLTMKESKSYEQSKALNKYTDNDTYIADDDEPKKDNQNVVEEKQINLTTSSDSHPTSTEDFGDKRASTVPTSENTSGFIEYFSQWHHFKHLLATAVSWFLLDIAFYGVNLNQSVILKAIGFSSGKNEYHTLMRGAIGNLIIAIAGYVPGYWFTVFLVEKLGRKWIQLQGLFITGLMFAILAGSWDTISTGGRFACFVIAQFFSNFGPNATTFLYPAEVFPARVRGTAHGLSAALGKCGAILASLLFNFLTSVIGYGNVMWIFCGCMWGAIFFTLLLPETKMRDADEIDREEVLRGGNGKTHQGRWSWYFNGIF
What is the function of this protein?
High-affinity transporter for external inorganic phosphate.
What are the official names of this protein?
Putative inorganic phosphate transporter C23D3.12.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: EOMES_XENLA
Sequence: MVPGAWHSLLFTTSSASEKEENRSQRMQLGEQLLNSSTPNLPHTFYPLTGDPSSAVHSPSLEFSVGHKGQQHKKYSSGSSRGLQLDSPREAGSSSTMLSETGEGFSVAKTLPDNVRKGSPSAEEELNTAVPTSAPRYLDGSLQAASERYYLQPQGQQLQQTTTELGSPCSIFPYAPPQHSAVYPAGGAARYPPYGSMLPPAGFSPPVCPSRPQYSSGYQYSQAPGTMYSPYPPAGTGSGLSALGLPGGGAGVRAQVFLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKVYVHPESPNTGAHWMRQEISFGKLKLTNNKGANNNSTQMIVLQSLHKYQPRLHIVEVSEDGVEDLNDSAKNQTFTFPENQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASESDRLTPSPADSPRSHQIVPGTRYSVQPFFQDQFVNNLPPARYYSGERTVPQANGLLSPQTNEEVANVPPQRWFVTPVQQAAANKLDMGAYETDYSSGSLLTYGIKSLPIQTSHPMAYYPDAAFASMAGWGSRGSTYQRKMTTSLPWSSRSSPSGFSEDLLPKDKVKEEMSSSWVETPPSIKSLDSNDSGVYTGACKRRRLSPSTSSNENSPPIKCEDIGTEDYKDATKGLGYYSFYSSS
What is the function of this protein?
Functions as a transcriptional activator playing a crucial role during development.  Functions in gastrulation, regulating mesoderm differentiation.  Activates wnt8, t/bra, chrd and mix-A/mix. 1 expression.
What are the official names of this protein?
Eomesodermin.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLPK1_SACS2
Sequence: MNTMSHKFVLALDEGTTSARAILFDSDLNIVNIGQYEFPQYYPQPGYVEHDPEEIWEAQMLAVKKAISKIDAKQIVAIGITNQRETTVLWDAKSGKPVYNAIVWQDRRTSPITDWLKANYFKMIKDKTGLVPDPYFSASKIKWILDNVPNVREKAERGEIKFGTLDTYLIWRLTNGKAHVTDYSNASRTMLFNINKLECDREILELLKIPESILPEVKPSSEIYGYSEALGNLIPISGDAGDQQAALFGQVAFNVGEIKATYGTGSFILMNIGNNPIRSENLLTTIAWGLEKNKATYALEGSIFITGAAVQWFRDGLRAIDVSDEIEPLASNVEDNGGVYFVPAFVGLGAPYWDPYARGLIIGITRGTTKAHIARAILESMAYQTRDVIEVMQKESGISINSLKVDGGAAKDNLLMQFQADILGIKVIRPKVMETTSMGVAMLAGLGVGLWNSLEELRSIWKVDKEFIPSMSEEKRRALYSGWKEAVKRAMGWAKVVGGQV
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase 1, ATP:glycerol 3-phosphotransferase 1, Glycerokinase 1, GK 1.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: TRHO_BURCM
Sequence: MTIVNLAAYHFVSIDATEQWRPLVTARCNELGLRGTILLAPEGINLFIAGPREATDAFIDYIRHDPLFEGKFATLQFKESLSDSQPFRRMLVRLKREIITMKKPAIKPELGRAPSVDARTLKAWLDRGHDDAGRPVVMLDTRNAFEVDVGTFDGALDYRIDKFSEFPEVIDANRADLEGRTVVSFCTGGIRCEKAAIHMKEIGIDNVYQLEGGILKYFEEVGGAHYHGDCFVFDYRTALNPQLQPTENVTCFACRAVVTPEAQQSPSYVPGKSCPACAQAASAA
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: TRUB_BARQU
Sequence: MVRQRKKRGRPVSGWVIFDKPKGMRSTEAVSQIKWLFHAQKAGHAGTLDPLASGLLPIALGEATKTVPYVMQGTKTYRFQIAWGEERSTDDLEGEITHISSKRPTQEEILALLPQYTGVILQTPPQFSAIKITGNRAYDLAREGKVVEIPPRQVEIETFKLIETPTRERSVFEITCGKGTYVRSLARDMGRDLGCYGHIADLRRTTVAPFCEDDLITWEELKAVALDKIAINENGIPSERNFTKIDELLIETGAALKCLSHYTLSETRAQ
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: LIPA2_MOUSE
Sequence: MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLTGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMVSSEGSTESEHLEGMEAGQKVHEKRLSNGSIDSTDDTSQIVELQELLEKQNYEMAQMKERLTALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESENFRKNLEESLHDKVSLAEEIEKLRSELDQMKMRTGSLIEPTISRTHIDTSTELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLGSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRAVRMTHTLPSSYHNDARSSLSASLEPDSLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLTAPAKTKESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC
What is the function of this protein?
Alters PTPRF cellular localization and induces PTPRF clustering.  May regulate the disassembly of focal adhesions.  May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.  In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines.
What are the official names of this protein?
Liprin-alpha-2, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2, PTPRF-interacting protein alpha-2.
What is the protein family that this protein belongs to?
Belongs to the liprin family. Liprin-alpha subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cell surface. Cell projection, dendritic spine. Note=Colocalizes with PTPRF at the cell surface.
Protein: E2MT2_AMOMA
Sequence: MFTLKKSMLLLFFLGTISLSLCEEERSADEDDGEKEVKRGIFSLIKTAAKFVGKNLLKQAGKAGMEHLACKANNQC
What is the function of this protein?
Antimicrobial peptide.  Active against a variety of Gram-negative and Gram-positive bacterial strains.  Active against fungi.  Shows strong hemolytic activity against human erythrocytes.
What are the official names of this protein?
Esculentin-2MT2.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Esculentin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RUBR_PYRAB
Sequence: MAKWRCKICGYIYDEDEGDPDNGISPGTKFEDLPDDWVCPLCGAPKSEFERIE
What is the function of this protein?
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide.  Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity).
What are the official names of this protein?
Rubredoxin, Rd.
What is the protein family that this protein belongs to?
Belongs to the rubredoxin family.
Protein: I1B3_CONRA
Sequence: MKLCLTFLLVLMILASVTGEKLSEQTLRRAARKNKGPRCWVGRVHCTYHKDCCPSVCCFKGRCKPQSWGCWSGPT
What is the function of this protein?
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels.  Produces general excitatory symptoms (By similarity).
What are the official names of this protein?
Iota-conotoxin-like R11.3.
What is the protein family that this protein belongs to?
Belongs to the conotoxin I1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPB_CLOBL
Sequence: MSNLGKVIQIIGPIIDIKFDSENLPDLFNALEINAGDRKVIAEVEQHIGDDTIRAIAMEDTEGLKRGMEALDTGKSVSVPVGKEVLGRLFNVLGKPIDGAGEFTSEESYPIHRPAPSFEEQSVEPEIFETGIKVIDLLAPYQKGGKIGLFGGAGVGKTVLIQELINNIAKEHGGLSVFTGVGERTREGNDLYYEMKESGVLEKTALVFGQMNEPPGARMRVALTGLTMSEYFRDQGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGALQERITSTKNGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRAITELGIYPAVDPLESSSRMLDPRIIGEEHYEVAIKVKNILERYRELQDIIAILGIDELSEEDKLVVGRARKIQRFLSQPFTVAEQFTGMQGKYVPIKETVRGFKEILEGKHDNIPESAFLFQGTIEDVLKKAQQMEI
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KAD_MAGSA
Sequence: MNLVLLGPPGGGKGTQAKRLQDKYGLVQLSTGDMLRAAVASGSEVGKKAKAVMDAGQLVSDEIVIAIIDERLDQADVAKGAIFDGFPRTVAQAEALDAMMAKKGKKLDFAIEIRVPDAYIVERITGRYTCAKCGAGYHDKFQLPQVAGKCDSCGGTEFARRPDDNVDTVTKRLDAYHAQTAPLLPYYDKKGSLKLVDGTMDIADVTKALEGILDASK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_VEREI
Sequence: MRHGHGLRKLNRSSSHRLAMLQNMMNSLIEHEVIKTTLPKAKELRRVIEPMITLAKQDSVANRRLAFNRLRERASVTKLFNVLGPHFRLRPGGYTRILKMGFRVGDNAPMALVELVDRPGVATEENNSASAEQ
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: G3P1_METAC
Sequence: MAKAKIAVNGYGTIGKRVADAVKAQDDMEVVGISKRTPNYEAAVAHQLGYDIYAPAENVGAFEKAGMPAAGSVEEMIEKADLVVDCTPGGVGEKNKPLYEKAGVKAIWQGGESHPIAGFSFNAVSNYEGALGRDLVRVVSCNTTGLCRTITPIDRELGVKKVRAILARRATDPNDIKKGPINAIVLHPVKLPSHHGPDVRSVIPHINITSAALLVPTTLMHLHTVNMEVDTDCTAEDIKKIFSSQSRIRFIGQGITSTAEIMEVARDIKRPRNDMWENCIWPESITVDEKEFYFFQAIHQESIVVPENVDAIRAMMELESDGAKSIEKTNKALGM
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 1, GAPDH 1, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMFO_METPB
Sequence: MTNPIHIVGGGLAGSEAAWQIAQGGRRAVLHEMRPRRGTEAHQGEGLAELVCSNSFRSDDANGNAVGLLHQEMRSLNSLIMRAADANQVPAGGALAVDREGFSQAVTAALEEHPNVTILREEVAGLPPETWGSTILATGPLTSPALAEAVGALTGRDALAFFDAIAPIVHRDSIDMGKAWFQSRYDKAGPGGTGADYLNCPMDREQYEAFVAALIAGEKTTFKEWEATTPYFDGCLPIEVMAERGPETLRHGPMKPVGLTNPHNPTVKAYAIVQLRQDNALGTLFNMVGFQTKLRHAEQVRIFRTIPGLENAEFARLGGLHRNTYLDSPRLLDATLRLRARPQLRFAGQITGCEGYVESAAVGLMAGRYALAEAEGTTLAPLPPTTALGALIGHITGGHLEASEDAGANAPRSFQPMNVNFGLFPPLERMPRNETGKRLRGPEKAALKKRALTDRAREDLAAWIGGEDLPHAAE
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIC_SULIM
Sequence: MGIIDEAKRGQITDEMRAISKLEGIPVEKVRNRISEGKIMLIRNAKYPSRKLVPIGKRLTTKVNVNIGTSSEVVDLDMELQKVKVANKWGDTLMDLSTGGDLDAIRRDIIKASDLPVGTVPVYQIFIESFKKKSGGAYFTEDELLNTVEKHLKDGVAFMTIHAGITKDLAIRALKSDRIIPIVSRGGDMIAGWMIHNNSENPYRKNWDYVLEMFKEYDAVISLGDALRPGATGDAHDEFQIGELLETARLVKSALQKGVQVMVEGPGHVPLNEIAWDVKLMKKLTGGVPYYVLGPLPIDVGAPYDHIASAIGAAISSASGVDLLCYLTPAEHLGLPTVKQVEEGAIAYRIAAHAGDVVKLGRKARKWDDEVSYYRGKLDWENMISKLIDPQRAYQVYTQFGTPKVKACTMCGGYCPMMWAMDQVRKIGSSSSL
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: VE7_HPV07
Sequence: MHGERPTLGDIVLDLQPEPVSLSCNEQLDSSDSEDDHEQDQLDSSHNRQREQPTQQDLQVNLQSFKIVTHCVFCHCLVRLVVHCTATDIRQVHQLLMGTLNIVCPNCAATA
What is the function of this protein?
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.  Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.  E7 protein has both transforming and trans-activating activities.  Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes.  Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation.  Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha.  Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
What are the official names of this protein?
Protein E7.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E7 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Predominantly found in the host nucleus.
Protein: GPI18_ASPOR
Sequence: MAAGLALARPNLLNPNNPIRSLSLAFWLWKAFVFLIIIGCPGPGYDTSTGLLPYQESAASGAKLEAIRHAPFSFPLKLVRWDSIYFVHIVRDDYVFEQEWAFGYGYTRILSFLTSVALSHIAHYFSVLALYRLSINIFGHDNTSGALISFLSATLHIICPAGAFLSAPYGESLFSFLNITGYFLYSSSLLDANAGKRASSDAKLLLAAALFSIATAVRSNGILSGALFAFDALLQLRKIFTQGISGDILLRLGVIVVGGCVIALGLIVPQWIAYTTFCMSDEPLRPWCEQLIPSIYGWVQVHYWNVGFLRYWTLSNLPLFILAFPMLFLMCRSSIWALNTAWPLDTATAVLTRLAAPNGLLAVMAFTSYHVQIINRISSGYPLWYWYIICQLSSHVADSSSVVKRSQTFSIAIQGMVIYAIVQAVLFGSFLPPA
What is the function of this protein?
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.  Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).
What are the official names of this protein?
GPI mannosyltransferase 2, GPI mannosyltransferase II, GPI-MT-II, Glycosylphosphatidylinositol-anchor biosynthesis protein 18.
What is the protein family that this protein belongs to?
Belongs to the PIGV family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DAPE_HAEI8
Sequence: MREKVVSLAQDLIRRPSISPNDEGCQQIIAERLEKLGFQIEWMPFNDTLNLWAKHGTSEPVIAFAGHTDVVPTGDENQWSSPPFSAEIIDGMLYGRGAADMKGSLAAMIVAAEEYVKANPNHKGTIALLITSDEEAAAKDGTIRVVETLMARDEKITYCMVGEPSSAKNLGDVVKNGRRGSITGNLYIKGIQGHVAYPHLAENPIHKAAPFLQELTTYQWDKGNEFFPPTSLQIANIHAGTGSNNVIPAELYIQFNLRYCTEVTDEIIKQKVAEMLEKHNLKYRIEWNLSGKPFLTKPGKLLDSITSAIEETIGITPKAETGGGTSDGRFIALMGAEVVEFGPLNSTIHKVNECVSIEDLGKCGEIYHKMLVNLLDS
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: PYRG_NITEC
Sequence: MTKFVFVTGGVVSSLGKGIAAASLAALLETRGIRVTILKLDPYINVDPGTMNPFQHGEVFVTDDGAETDLDLGHYERFISTKMTRRNNFTTGQIYESVIRKERRGDYLGGTVQVIPHITDEIKLFIRNGVSDAQVAIVEIGGTVGDIESLPFLEAIRQMSVQLPHHDTCFIHLTLLPYISSAGELKTKPTQHSVKELREIGIQPDVLLCRSDRPLPLDERRKIALFTNVREESVISAIDVDNIYKIPALLHEQMLDEIVCHRLGILAKPANLTTWKKLIHALEHPEHEVSIALVGKYVDLTESYKSLSEALIHAGIHTRCKINIHYIDSENIERHGTGCLANMDAILVPGGFGKRGVEGKIMAISHARNHQIPYLGICLGMQLAVIEFARNCLQLENAHSTEFNPDTPYPVLGLITEWRDRRGQIEKRSPQTDLGGTMRLGGQECLLKPHTLARKIYGTDKIIERHRHRYEVNAEFIPQLEQAGLQVSGLSAAENLCEMIELPQSRHPWFVACQFHPEFTSTPRNGHPLFNDYVRAAISFADKSGHAKLRDHNMQKNVATDSTH
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: YWHD_BACSU
Sequence: MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEEKEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACEMTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSSDELKTSLLPENN
What are the official names of this protein?
Uncharacterized protein YwhD.
Protein: RS5_WOLPM
Sequence: MAIKNLQNNNDLSELLVSVRRVTTVTKGGRRFSFSILVVVGDEKGRVGCGIGKHAEVAEARVKAVNAAKKSMIRVYLREGRTLHHDIKAKFCSGEIVLRTARAGTGIIAGGAIRSVFEVLGIKDVVAKSTRSNNPHNVICAVFKAFDSMLSPRQVASKRGKKISEIVGNR
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.