PharMolix/UniProtQA huggingface dataset:
Protein: RBMX_BOVIN
Sequence: MVEADRPGKLFIGGLNLETDEKSLEATFGKYGRISEVLLMKDRETNKSRGFAFITFESPADAKAAVRDMNGKSLDGKAIKVAQATKPAFESGRRGPPLSRSRGRSRGLRGARGGGPRRPPSRGGPADDGGYAGDFDLRPSRAPLPMKRGPPPPRRAGPPPKRAAPSGPARSGSGGGMRGRAPAARGRDGYEGPPRRDPPPPRRDPYLGSREGGYSPRDGYSSRDYSSARDARDFAPSPREYTYRDYGHSSARDECPSRGYGDRDGYGGRDRDYADHPSGGSYRDPFESYGDPRSAAPARGPPPSYGGGGGRYEEYRGCSPDAYGGGRDGYAGGRSERYSGGRDRVGRADRGLPQSVERGCPPPRESYSRSGRKVPRGGGRLGSRSERGGGGGRSRY
What is the function of this protein?
RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes.  Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs.  Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression.  When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter.  Associates with nascent mRNAs transcribed by RNA polymerase II.  Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection.  Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2.  Represses the splicing of MAPT/Tau exon 10.  Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer.  Binds non-specifically to pre-mRNAs.  Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity).
What are the official names of this protein?
RNA-binding motif protein, X chromosome, Heterogeneous nuclear ribonucleoprotein G, hnRNP G.
What are the subcellular locations of this protein?
Nucleus. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus (By similarity).
Protein: MIAB_ACIBY
Sequence: MTVQTFIPNGAKAASENTVTQPTHTTDVSIKKLYIETQGCQMNEYDSHRMADLLGDSHGYVLTNNPNEADILLMNTCSIREKAQEKVFSELGRWRKLKEQNPDLVIGVGGCVASQEGDNIQKRAPYVDMIFGPQTLHRLPQMLDQHHAQVEKPKKEKIKLVDISFPDIEKFDFLPEPRVEGFKAFVSIMEGCSKYCSFCVVPYTRGEEVSRPLDDVLAEIAGLAEKGVREISLLGQNVNGYRGETFEGGICTFPELLRLVAEIPGIGRLRYTTSHPLEFSDELIQCYEDLPQMVSHLHLPVQSGSNDVLKAMKRNHTIDVYIDKIAKLRKIRPDMHLSSDFIIGFPGETDENFAETLQFIKDLDFDHSYSFVYSKRPGTPASDLPDTTPEHVKKERLAQVQQVIKQSSIEKTDAMLGKIERVLIEKVSDQDPNILVGTADNTRLVTFVGDASWVGRFAEIEITEIKTLNLVYGELLNLEPDVA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_RANGL
Sequence: MEELQRYLKMDRSRERDFLYPLLFQEYIYALAHDFGLTKSIPYESMQILSYDNKYSSLIVKRLIIRMYQQKHLIILDNDSNQKNFLGHNKNLYSQMISEGFAVIVEIPFALRLVSSYQGKEIEKSINLRSIHSTFPFLEDKFVHLNHVLDILIPYPIHLELLVQNLRCWIQDASFLHLLRFFLYEYHNWNSLTTQKTKQNPLFFKENRRFFLFLYNFHVYESESIFLFLRKKSYHLRSTSSIAFLDRTHFYGKIEHFQVVFRNYFHTILWLFKDPFMHYFRYQGKSIMSSKGTPLLMKKWKYYLVNLWECHFYFWSQPDRIHINQLSNHFLDFLGYLSSVRPNPSVVRNQMLENAFIIDIAINKLDTIVPIIPLIGSLAKAKFCNLSGQPVSKPAWTDSPDSDIIDRFGRICRNVSHYYSGSSKKKTLYRIKYILRLSCARTLARKHKSTVRSFLKRLGSEFLEEFLIEEEQVLSFILPKISSSSQRLSKERVWYFDIIRINDLMDLS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LLDD_XANOP
Sequence: MIISAASDYRAAAQARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALGPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGVLGKPHDLGNISAYRGNPTGLQDYIGWLGANFDPSIAWKDLEWIREFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAADGQAGVENLLTLIEKEMRVAMTLTGTHSIAQISADALSRVTREQANAVSP
What is the function of this protein?
Catalyzes the conversion of L-lactate to pyruvate.  Is coupled to the respiratory chain.
What are the official names of this protein?
L-lactate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TOLB_CHRSD
Sequence: MKRLNLWAASLLLMLCAGMAHAELTIEITKGSDQAIPIAIVPMANGDDLPENVSRIVSNDLERSGRFEPLPRESLISRPSSSEEVHYQDWQQLDSDYLVVGKIDNQGGEYRIQYELLNVNGQNRMLGEVVTSSRDQLRDSAHYISDQIFEEITGIRGAFSTSIAYVTASGVGDDIDYALSVADADGHNSQQILSSDEPILSPAWSPDGGKLAYVSFETGRPGIYVQNLATGQRVRLTSFEGINGAPAWSPDGRKLAMSLSKDGQPEIYVMDIASRDLRRLTQSDAIDTEPEWAPNGRSLIFTSDRSGNPQIYRYDLGSGRAERLTFTGSYNSRGRFSPDGDAIFMVTRDDSGYHVARQDLDTDRMTILTDSDWDESPSVAPNGTMVIFATQEGTRGVLGAVSADGSASFRLPSPQGDVREPAWSPFLD
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: C94A2_VICSA
Sequence: MELETLISWLLFSTSLFWFLFLATKTKSKPPKTPSSTTNTPIPKSYPIFGSAFSLLANFHRRIQWTSDILQTIPSSTFVLHRPFGARQVFTAQPAVVQHILRTNFTCYGKGLTFYQSINDFLGDGIFNADGESWKFQRQISSHEFNTRSLRKFVETVVDVELSDRLVPVLSQASNSQTTLDFQDILQRLTFDNICMIAFGYDPEYLLPSLPEIPFAKAFDESSQLSIERLNALIPLLWKVKRFLNIGVERQLKEAVAEVRGLATKIVKNKKKELKEKALQSESESVDLLSRFLSSGHSDESFVTDMVISIILAGRDTTSAALTWFFWLLSKHSHVENEILKEITGKSETVGYDEVKDMVYTHAALCESMRLYPPLPVDTKVAVHDDVLPDGTLVKKGWRVTYHIYAMGRSEKIWGPDWAEFRPERWLSRDEVGKWSFVGIDYYSYPVFQAGPRVCIGKEMAFLQMKRVVAGIMGRFRVVPAMVEGIEPEYTAHFTSVMKGGFPVKIEKRSPLV
What is the function of this protein?
Catalyzes the omega-hydroxylation of various fatty acids (FA).  The substrate specificity is higher for myristate > laurate = palmitate (C14>C16=C12).
What are the official names of this protein?
Cytochrome P450 94A2, P450-dependent fatty acid omega-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RUTE_ECO5E
Sequence: MNEAVSPGALSTLFTDARTHNGWRETPVSDETLRELYALMKWGPTSANCSPARIVFIRTAEGKERLRPALSSGNLQKTLTAPVTAIVAWDSEFYERLPQLFPHGDARSWFTSSPQLAEETAFRNSSMQAAYLIIACRALGLDTGPMSGFDRQHVDDAFFAGSTLKSNLLINIGYGDSSKLFARLPRLSFEEACGLL
What is the function of this protein?
May reduce toxic product malonic semialdehyde to 3-hydroxypropionic acid, which is excreted.
What are the official names of this protein?
Probable malonic semialdehyde reductase RutE.
What is the protein family that this protein belongs to?
Belongs to the nitroreductase family. HadB/RutE subfamily.
Protein: RS2_CHLSY
Sequence: MTQALPRVVTIRELLEAGAHFGHPTNRWNPKMKPYIFTARNGIHIIDLQKTVTGLSRAYQFITELTARGEKVLFVGTKKQAQEAVMEEAVRSGQFYINQRWLGGTLTNFATIKRRLKLLSDLEEQRDRGDFARLTKAEAAKLEEKIVRLNRVFAGLKGMDRLPGAVFIIDPRKEELAVREAVKEGIPIVAMVDTNCDPDPIDYVIPCNDDAIRGIRLMAGKIADAAIEGTRRREMSQE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: EFTU2_ALKMQ
Sequence: MGKAKYERSKPHVNIGTIGHVDHGKTTLTAAITITMHNRYGTGGAVAFDMIDKAPEERERGITISTAHVEYETDKRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLSRQVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLNMYEFPGDDTPVIMGSALKALEDPAGPWGDKIVELFDAIDTWIPEPVRDTDKPFLMPVEDVFSITGRGTVATGRIERGIVKVQEEISLVGLSEAPRKLVVTGVEMFRKLLDQGQAGDNVGILLRGIQRDEIERGQVLAKTGSIQPHTKFMAEVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGSIKLPEGVEMVMPGDNITMEIELISPIATEEGLRFAIREGGRTVGAGVVASIIE
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu 2, EF-Tu 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GAL1_CHLSY
Sequence: MYELSTLYAAFEQYFGHPPTRIARAPGRVNLIGEHTDYNDGFVFPMALDRATYVAARPRNDQIVRVFSIKFRDEDQFDLQQIVRDERRQWVNYIRGVAKGLLARDLPLRGADLMIDSDVPAGSGLSSSAALEVAVGYTFQLLNNINLLGEELALVAQGAEHTFVGVKCGIMDQLIAALGEAGHALLIDCRDLSYRPVPIPAEARVVVCDSGVRHRLAGSEYNQRRAGCEEAVRLLKPALGKIQALRDVRSSDLAMYGHLLPPDLLPLARHVVSENERTLAAAEALAAGDLVKMGQLMVASHVSLRDDYRVSVRELDTLVDLALAAPGCFGSRMTGGGFGGSTVSLVAADHVDAFVAAMVDGYAIRTGRKLQPLVCTAGAGVSCVYASEEE
What is the function of this protein?
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
What are the official names of this protein?
Galactokinase, Galactose kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. GalK subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL28_ALKOO
Sequence: MARVCEVCAKGKVSGNVVSHSNRHNRRTWEPNLRRVRAIVNGTAKRINVCTRCLRSGRVERAL
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: RRT14_CANTT
Sequence: MSSSFSSDASQYQAENTVNKLFSNILHTNISTTKSTTNANQLFAQHGSSVKKNKKNEAKRIKKNEERTKAFNKFVKYNYIKNKENKNESDKKYLSKLVRKNVNKLNSSSKIDDFEINEEFNIVSSELLDQIKPKNGKRLRKKLFRVNENDERAKEFNEKLQKGVISYPGLTPGLAPVDYNESDSE
What is the function of this protein?
Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
What are the official names of this protein?
Regulator of rDNA transcription 14.
What is the protein family that this protein belongs to?
Belongs to the RRT14 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PUR5_ECODH
Sequence: MTDKTSLSYKDAGVDIDAGNALVGRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPVLVSGTDGVGTKLRLAMDLKRHDTIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDTASAVISGIAEGCLQSGCSLVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVSDGDVLIALGSSGPHSNGYSLVRKILEVSGCDPQTTELDGKPLADHLLAPTRIYVKSVLELIEKVDVHAIAHLTGGGFWENIPRVLPDNTQAVIDESSWQWPEVFNWLQTAGNVEHHEMYRTFNCGVGMIIALPAPEVDKALALLNANGENAWKIGIIKASDSEQRVVIE
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSR5_BOVIN
Sequence: MEPLFPASPLTTWNTSSVVPSGSGDENGTLAGLGPSPGARAVVVPVLYLLVCAVGLGGNTLVIYVVLRHAKMKTVTNIYILNLAVADVLLMLGLPFVATQNAISYWPFGPVLCRLVMTLDGINQFTSIFCLTVMSVDRYLAVVHPIRSARWRRPRVAKLASAAVWAFSLVMSLPLVVFADIQEGWNTCNLSWPEPVGLWGAVFIIYTSVLGFFGPLLVICLCYLLIVVKLKASGVRVGSTRRRSERKVTRMVVVVVLVFAGCWLPFFIVNIVNLAFALPEEPASAGAYFFVVVLSYANSCANPLLYGFLSDNFRQSFRKVLCLRKGYGAGAEDADATEPQPGPSSRLQEAMMPVRSCKANGLMQTSKL
What is the function of this protein?
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14.  The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.  Increases cell growth inhibition activity of SSTR2 following heterodimerization (By similarity).
What are the official names of this protein?
Somatostatin receptor type 5, SS-5-R, SS5-R, SS5R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ACUC_STAAN
Sequence: MQQHSSKTAYVYSDKLLQYRFHDQHPFNQMRLKLTTELLLNANLLSPEQIVQPRIATGDELMLIHKYDYVEAIKHASHGIISEDEAKKYGLNDEENGQFKHMHRHSATIVGGALTLADLIMSGKVLNGCHLGGGLHHAQPGRASGFCIYNDIAITAQYIAKEYNQRVLIIDTDAHHGDGTQWSFYADNHVTTYSIHETGKFLFPGSGHYTERGEDIGYGHTVNVPLEPYTEDASFLECFKLTVEPVVKSFKPDIILSVNGVDIHYRDPLTHLNCTLHSLYEIPYFVKYLADSYTNGKVIMFGGGGYNIWRVVPRAWSHVFLSLIDQPIQSGYLPLEWINKWKHYSSELLPKRWEDRLNDYTYVPRTKEISEKNKKLALHIASWYESTRQ
What is the function of this protein?
Role in growth on acetoin or butanediol.  Involved in the breakdown of these compounds used as a carbon source (By similarity).
What are the official names of this protein?
Acetoin utilization protein AcuC.
What is the protein family that this protein belongs to?
Belongs to the histone deacetylase family.
Protein: RFX2_DANRE
Sequence: MQRSEGGSETPSTVALRTSTSAQAPVVQPVPASQQRVLVQATGSSQKGAQVQQLPVPRVQQVPQQVQQVQHYHSQQVQYVEGAEAVYPNGTIRAAYSYNPESQLYGQGSGSAYFDSQAGGAQVTTVVSSGGVPTHGMVGIAMDVGGSQIISSGSAYLIHGGMEGGRHHTSHSSRSSSAMLEMAIENLQKSEGIATHKSSLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRMQEDTQYMAMRQTPVHQKQRFKPFHKMDGMGDSLNSGSQHLSSTPEQSVAAQCQHHQQYIDVSHVLPPFPSLDLGSCPLPESISMTDVKKLQSSYRIHCEATLDVVMNLQFHLIEKLWQTFWHSTAPSSDGATTIPNSEEDVEDIRGFPRDKLITLCKYEPIKQWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTSAMTNFPPEIISTKAAVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDESVVQRLELDFKATLQQQSSLDQWAAWLDNVVNQVLKPYDGSLSFPRAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFSDLSSLMPSLKEQDTSFSDDMTSDGDMSRMSERSLTEPAVKRERIEIPHSLQEI
What is the function of this protein?
Transcription factor that acts as a key regulator of ciliogenesis (PubMed:22233545).  Specifically regulates expression of genes required for cilium assembly and function (PubMed:22233545).  Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (By similarity).
What are the official names of this protein?
DNA-binding protein RFX2, Regulatory factor X 2.
What is the protein family that this protein belongs to?
Belongs to the RFX family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Mainly expressed in the nucleus and at lower level in cytoplasm.
Protein: HEXA_ASPOZ
Sequence: MRISQICTVLSTVTSAVAVGVNPLPAPREISWGSSGPKSIAGELQLRTDSDSADGIVADAWNRAWETIVALRWVPAATEAPISSFEPFPTPTAGASKKSKRASNSLQYVNVQVKDIEADLQHGVDESYTLDVEEDSDTITINAETVWGALHAFTTLQQLVISDGHGGLIIEEPVNIKDSPLYPYRGIMLDTGRNFVSLPKIFEQLEGMSLSKLNVLHWHIDDAQSWPIWVDVYPEMVKDAYSPHEIYSRNDVRNIVNYARARGIRVIPEIDMPSHSSSGWKQVDPEMVTCTDSWWSNDDWPLHTAVEPNPGQLDIIYNKTYEVVGNVYKELSDIFPDHWFHVGGDEIQPNCFNFSTHVTKWFAEDPSRTYHDLAQYWVDHAVPIFQNYSQERRLVMWEDIALSADNAHDVPKNIVMQSWNNGLEYISNLTARGYDVIVSSSDFLYLDCGHGGFVTNDPRYNVMANPDANTPNFNYGGNGGSWCAPYKTWQRIYDYDFTLNLTETQAKHIIGATAPLWGEQVDDINVSSMFWPRAAALAELVWSGNRDANGNKRTTEMTQRILNFREYLVANGVQAQALVPKYCLQHPHACDLYRNQAAIQ
What is the function of this protein?
Selectively hydrolyzes GlcNAcbeta(1->4)GlcNAc (N,N'-diacetylchitobiose) and Gal-NAcbeta(1->4)GlcNAc, but not their C-2 epimers GlcNAcbeta(1->4)ManNAc or Gal-NAcbeta(1->4)ManNAc.  However, hydrolyzes both GlcNAcbeta(1->6)GlcNAc and GlcNAcbeta(1->6)ManNAc (Ref. 7).  Part of the binary chitinolytic system.  Involved in hydrolyzation of chitobiose and higher chito-oligomers (produced from cell wall chitin by endochitinases), thus contributing to the formation of germ tubes, fruit-bodies and septa during hyphenation (Probable).  Hydrolyzes synthetic substrate p-nitrophenyl-beta-N-acetyl-D-glucosaminide (pNP-GlcNAc) (PubMed:17302431, PubMed:12723619, Ref. 7).  Hydrolyzes synthetic substrate p-nitrophenyl-beta-N-acetyl-D-galactosaminide (pNP-GalNAc) (PubMed:12723619).  Hydrolyzes chromogenic substrate 4-nitrophenyl-2-acetamido-2-deoxyglucopyranoside (PubMed:21505251, PubMed:17509134, PubMed:29239122).
What are the official names of this protein?
Beta-hexosaminidase, AoHEX, Beta-N-acetylglucosaminidase, Beta-N-acetylhexosaminidase, Hex.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 20 family.
What are the subcellular locations of this protein?
Secreted.
Protein: LACB2_HUMAN
Sequence: MAAVLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIPEYISCLKQALTEFNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKKLPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHMALLLEEENAIFSGDCILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVIHNAEAKIQQYISHRNIREQQILTLFRENFEKSFTVMELVKIIYKNTPENLHEMAKHNLLLHLKKLEKEGKIFSNTDPDKKWKAHL
What is the function of this protein?
Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA.  The cleavage product contains a free 3' -OH group.  Has no activity with double-stranded RNA or DNA.  Required for normal mitochondrial function and cell viability.
What are the official names of this protein?
Endoribonuclease LACTB2, Beta-lactamase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: KAX72_PANIM
Sequence: TISCTNEKQCYPHCKKETGYPNAKCMNRKCKCFGR
What is the function of this protein?
Potent inhibitor of the A-type voltage-gated potassium channels.  Most potent inhibitor of Kv1. 2/KCNA2 channels.  Reversibly block the Shaker B potassium-channels (Kv1. 1 sub-family), but with a lower affinity than PiTX-K alpha.
What are the official names of this protein?
Potassium channel toxin alpha-KTx 7.2, Pandinotoxin-beta, Potassium channel-blocking toxin 3, Pi-3, Pi3, Toxin PiTX-K-beta.
What is the protein family that this protein belongs to?
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 07 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SLB1_MACLB
Sequence: MGRIIFVSFGLLVVFLSLSGTGAALNCASGWSGYDQHCYKVFDKPKSWADAEKFCKKQTSGGHLVSFHSSEETDFVVELVSQTLESQILWMGLSKVWNQCDWGWSNGAKLKYKAWAEESYCVYFSSTKKGWRSRACRLLGHFVCKSPA
What is the function of this protein?
Interferes with one step of hemostasis (modulation of platelet aggregation, or coagulation cascade, for example).
What are the official names of this protein?
Snaclec B1, C-type lectin B1.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: TILS_AROAE
Sequence: MLVAAAVAPRQRLCVAFSGGADSTTLLHLLARLRPRFGFDLCAAHVHHALSPNADAWLDFCARQCAALDVAFHPFREQVARDHPAGLEAAAREVRHAALSRVTCDWLVFGHHQDDQAETLLFRLLRGAGVRGAAAMAAIEPGFPGRLRPLLGVRRADIRAFAQAASLEWIEDESNADPRHARNFLRHHVFPLFGEAFPGAVPALARASGHFREADGLLGDLAALDYAACGGSPWLRDRLLMLSDERVRNLLRWRIRQMGCEAPARARLVEAVRQLRATHAPLYLPLGTAACCTYRDRLWLEPQRDGAPEQPLPWRQEPALCWGAGVVRFEPVTGAGIGRGALQRAMDVALVPRWPGLMLRQDSGRPLRSFKNLCQEAGIPAWLRPRLPVLRVDGEAAWIGEIGVAAEFRCGPGEAGLLLVWQR
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH2_BART1
Sequence: MYVFCICDLSKRFSLSFQPNFLCELGLQKQGFFHVAGVDEVGRGPLAGPVVTAAVILDKDRIPDGLNDSKKLSFLQRNRLYHEILQSALAASIASLCARTIDQSNIRKATLEAMRRCIIGLAVPAHYVLVDGRDIPSELPCPAMALIKGDQRSVSIAAASIIAKVTRDRMMECAGQVYTNYGLEKHVGYATLAHRRALDKYGPIVGLHRYSFAPLKERYRNDVS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK5_PRIVA
Sequence: FGETSGETKGMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, FXPRL-amide, PriVa-Capa-PK.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: PPAX_HALH5
Sequence: MEINTVLFDLDGTLINTNELIISSFLHTFETYYPGKYGRKDAIECIGPPLTDSFKRLDPERVEEMVATYRKHNHAHHDKLVEPYEGVYETVKTLHEQGFKLAIVTTKIRETAMKGLKLFGLDEFFDVIVALDDVENVKPNPEPLEKAMNALGAKKEETIMVGDNSHDILGGKNAGVKTAVVGYAIRGEDYVRQFDPDYVLRSMPDLLDIVGVKAR
What is the function of this protein?
Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P.  Might play a role in controlling the intracellular pyrophosphate pool.
What are the official names of this protein?
Pyrophosphatase PpaX.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. PpaX family.
Protein: TR30A_MOUSE
Sequence: MASSVLEMIKEEVTCPICLELLKEPVSADCNHSFCRACITLNYESNRNTDGKGNCPVCRVPYPFGNLRPNLHVANIVERLKGFKSIPEEEQKVNICAQHGEKLRLFCRKDMMVICWLCERSQEHRGHQTALIEEVDQEYKEKLQGALWKLMKKAKICDEWQDDLQLQRVDWENQIQINVENVQRQFKGLRDLLDSKENEELQKLKKEKKEVMEKLEESENELEDQTELVRDLISDVEHHLELSTLEMLQGANCVLRRSQSLSLQQPQTVPQKRKRTFQAPDLKGMLQVYQGLMDIQQYWVHMTLHARNNAVIAINKEKRQIQYRSYNTVPVSEIYHLGVLGYPALSSGKHYWEVDISRSDAWLLGLNDGKCAQPQLHSKEEMGIKKNLHSQIKQNVLFQPKCGYWVIGMKNPSVYKAFDECSITHNSSILVISLPDRPSRVGVFLDRKAGTLSFYDVSNCGALIYRFYDPAFPVEVYPYFNPMKCSEPMTICGPPS
What is the function of this protein?
Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain.  May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences.  Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination.  Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex.  This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18.  No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses.
What are the official names of this protein?
Tripartite motif-containing protein 30A, Down regulatory protein of interleukin-2 receptor, Tripartite motif-containing protein 30.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: OAT1_STAAM
Sequence: MNSIIELTDYYSSNNYAPLKLVISKGKGVKVWDTDGKQYIDCISGFSVANQGHCHPTIVKAMTEQASKLSIISRVLYSDNLGKWEEKICHLAKKDKVLSLNSGTEAVEAAIKIARKWGSEVKGITDGQVEIIAMNNNFHGRTLGSLSLSNHDAYKAGFHPLLQGTTTVDFGDIEQLTQAISPNTAAIILEPIQGEGGVNIPPKGYIQAVRQLCDKHQILMIADEIQVGLGRTGKWFAMEWEQVVPDIYILGKALGGGLYPVSAVLANNDVMRVLTPGTHGSTFGGNPLAIAISTAALDVLKDEQLVERSERLGSFLLKALLQLKHPSIKEIRGRGLFIGIELNTDAAPFVDQLIQRGILCKDTHRTIIRLSPPLVIDKEEIHQIVAAFQDVFKN
What is the function of this protein?
Catalyzes the interconversion of ornithine to glutamate semialdehyde.
What are the official names of this protein?
Ornithine aminotransferase 1, OAT 1, Ornithine--oxo-acid aminotransferase 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
What are the subcellular locations of this protein?
Cytoplasm.