PharMolix/UniProtQA huggingface dataset:
Protein: SURE_RHOPT
Sequence: MRILCTNDDGIHAPGLKTVEQIARAISDDVWVVAPELDQSGVSHSLSLNDPLRLREVGPRHFAVRGTPTDCVIMGSRFILKDKAPDLVLSGVNRGRNVAEDVVYSGTIAGALEGTILGLPSFALSQEFTIETRNAPLWETARTHAPDIIRKVMAAGVPKNTVVNINFPACTPDKVKGVVVTRQGKRNPGFLRIDERHDGRGNPYYWIGFERIKVEDMPAEGTDLAALAANFVSVTPLKLDRTDETFSAALANTLA
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRAA_SHIBS
Sequence: MKYDTSELCDIYQEDVNVVEPLFSNFGGRASFGGQIITVKCFEDNGLLYDLLEQNGRGRVLVVDGGGSVRRALVDAELARLAVQNEWEGLVIYGAVRQVDDLEELDIGIQAMAAIPVGAAGEGIGESDVRVNFGGVTFFSGDHLYADNTGIILSEDPLDIE
What is the function of this protein?
Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity.  Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.  Modulates RNA-binding and helicase activities of the degradosome.
What are the official names of this protein?
Regulator of ribonuclease activity A.
What is the protein family that this protein belongs to?
Belongs to the RraA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPIKE_CVCAI
Sequence: MIVLTLCLFLFLYSSVSCTSNNDCVQVNVTQLPGNENIIKDFLFQNFKEEGSLVVGGYYPTEVWYNCSTTQQTTAYKYFSNIHAFYFDMEAMENSTGNARGKPLLVHVHGNPVSIIVYISAYRDDVQFRPLLKHGLLCITKNDTVDYNSFTINQWRDICLGDDRKIPFSVVPTDNGTKLFGLEWNDDYVTAYISDESHRLNINNNWFNNVTLLYSRTSTATWQHSAAYVYQGVSNFTYYKLNKTAGLKSYELCEDYEYCTGYATNVFAPTSGGYIPDGFSFNNWFMLTNSSTFVSGRFVTNQPLLVNCLWPVPSFGVAAQEFCFEGAQFSQCNGVSLNNTVDVIRFNLNFTTDVQSGMGATVFSLNTTGGVILEISCYNDTVSESSFYSYGEIPFGVTDGPRYCYVLYNGTALKYLGTLPPSVKEIAISKWGHFYINGYNFFSTFPIDCIAFNLTTGASGAFWTIAYTSYTEALVQVENTAIKKVTYCNSHINNIKCSQLTANLQNGFYPVASSEVGLVNKSVVLLPSFYSHTSVNITIDLGMKRSVTVTIASPLSNITLPMQDNNIDVYCIRSNQFSVYVHSTCKSSLWDNNFNSACTDVLDATAVIKTGTCPFSFDKLNNYLTFNKFCLSLNPVGANCKLDVAARTRTNEQVFGSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRTGVGIIRKTNSTLLSGLYYTSLSGDLLGFKNVSDGVVYSVTPCDVSAQAAVIDGAIVGAMTSINSELLGLTHWTTTPNFYYYSIYNYTNVMNRGTAIDNDIDCEPIITYSNIGVCKNGALVFINVTHSDGDVQPISTGNVTIPTNFTISVQVEYIQVYTTPVSIDCARYVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEIDSMLFVSENALKLASVEAFNSTENLDPIYKEWPNIGGSWLGGLKDILPSHNSKRKYRSAIEDLLFDKVVTSGLGTVDEDYKRSAGGYDIADLVCARYYNGIMVLPGVANDDKMTMYTASLTGGITLGALSGGAVAIPFAVAVQARLNYVALQTDVLNKNQQILANAFNQAIGNITQAFGKVNDAIHQTSKGLATVAKALAKVQDVVNTQGQALSHLTVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLTALNAFVSQTLTRQAEVRASRQLAKDKVNECVRSQSQRFGFCGNGTHLFSLANAAPNGMIFFHTVLLPTAYETVTAWSGICASDGSRTFGLVVEDVQLTLFRNLDEKFYLTPRTMYQPRVATSSDFVQIEGCDVLFVNGTVIELPSIIPDYIDINQTVQDILENFRPNWTVPELPLDIFHATYLNLTGEINDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKWPWYVWLLIGLVVIFCIPILLFCCCSTGCCGCIGCLGSCCHSICSRGQFESYEPIEKVHVH
What is the function of this protein?
S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection.  Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion.  S2 region belongs to the class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
What are the official names of this protein?
Spike glycoprotein, S glycoprotein, E2, Peplomer protein.
What is the protein family that this protein belongs to?
Belongs to the alphacoronaviruses spike protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Note=Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly.
Protein: NTPP_CORGL
Sequence: MQIVLASQSPSRRRILNSAGVEPLIHPADVDEDALLHSLNGSAPEEIVRQLALAKAQVVAPSYPGDVVIGGDSMLLIDATLQGKPHTREATIERWKQQRGNKATLITGHAIIFGDEVIVESSSTNIHFAEASDVDIERYADSGEPLECAGAFTLEALGGWFIDSIEGDPSSVIGLSLPVVRRALYRLGFNASDFWNM
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRXB_NEUCR
Sequence: MHSKVVIIGSGPAAHTAAIYLARAELKPVLYEGFMANGIAAGGQLTTTTEIENFPGFPDGIMGQELMDKMKAQSERFGTQIISETVAKVDLSARPFKYATEWSPEEYHTADSIILATGASARRLHLPGEEKYWQNGISACAVCDGAVPIFRNKHLVVIGGGDSAAEEAMYLTKYGSHVTVLVRKDKLRASSIMAHRLLNHEKVTVRFNTVGVEVKGDDKGLMSHLVVKDVTTGKEETLEANGLFYAIGHDPATALVKGQLETDADGYVVTKPGTTLTSVEGVFAAGDVQDKRYRQAITSAGTGCMAALDAEKFLSEHEETPAEHRDTSAVQGNL
What are the official names of this protein?
Thioredoxin reductase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_PSEFL
Sequence: MAHNEAVDVVHVVLVGAGIMSATLAVLLKELDPAISLEVVELMDSGAAESSNPWNNAGTGHAGLCELNYTPQAADGNVDIKKAVHINTQFEVSKQFWTYLTRKGTFGSSKSFIAPVPHLSFVQGEKGVSFLKKRFELMHQHHAFADMEYTEDKARMAEWMPLMMPGRPADEVIAATRVMNGTDVNFGALTNQLLKHLTSAPDTQVKYCKRVTGLKRNGSGWTVSIKDVNSGSSRDVDAKFVFLGAAGAALPLLQASGIEESKGFGGFPVSGQWLRCDNPEVVKHHQAKVYSQAAVGSPPMSVPHLTPVWSMARNPCLFGPYAGFTTKFLKHGSIMDLPLSVRAGNIGPMLAVARDNMDLTKYLISEVMQSMEQRLESLRRFYPEAKAEDWRLEVAGQRVQIIKKDPKKGGVLQFGTELVAAKDGSLAALLGASPGASVTVSIMLELIERCFPDKAKGEWATKLAEIFPAREKVLETDAALYRKINAQNNIALELVEESSETQSYA
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: ATPB_CYACA
Sequence: MKPCQLKQKQKTLAIAKVNNKGKVIQIIGPVLDIVFPDGQLPKVFNAIKINNSNNNWITCEVQQLLGDNKVRAVAMSTTEGLKRGASAIDTGEPISIPVGKETLGRIFNVLGEPIDEKGPVISNDKLPIHRPAPKFTQLETKPSIFETGIKVVDLLAPYRRGGKIGLFGGAGVGKTVLIMELINNVAKAHGGVSVFGGVGERTREGNDLYQEMKESGVINEKDLNLSKVALCYGQMNEPPGARMRVGLTALTMAEYFRDVNKQNVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTEMGALQERITSTLDGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRALAAKGIYPAVDPLDSTSTMLQPGIVSDEHYTTARKVKETLQRYKELQDIIAILGLDELSEEDRLIVSRARKIEKFLSQPFFVAEVFTGISGKYVSLSDSIKGFNMILSGEVDNIPEQAFYLVGRIEEAIDKAKQVEKS
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, chloroplastic, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RS4_STACT
Sequence: MARFRGSNWKKSRRLGISLSGTGKELEKRPYAPGQHGPNQRKKLSEYAIQLREKQKLRYLYGITERQFHNTFIEAGKQSGVHGENFMRLLARRLDAVVYALGLARTRRQARQLVGHGHIEVDGKRVNIPSYTLKPGQVVSVREKSQKLDIIQESVEINNFVPEYLDFDEEKLSGTFVRVPERSELPAEINEQLIVEYYSGK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: CLIC3_MOUSE
Sequence: MAETTKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRALDVLKDFAPGSQLPILLYDGDVKTDTLQIEEFLEETLGPPDFPSLAPRYRESNTAGNDIFHKFSAFIKNPVPTQDNALYQQLLRALTRLDSYLRAPLDHELAQEPHLRESHRRFLDGDQFTLADCSLLPKLHIVDTVCAHFRQLPIPAELSCVRRYLDSALQKKEFKYTCPHSAEILAAYQPAVHPR
What is the function of this protein?
Can insert into membranes and form chloride ion channels.  May participate in cellular growth control (By similarity).
What are the official names of this protein?
Chloride intracellular channel protein 3.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity).
Protein: SYE_RHOPT
Sequence: MTRPVVTRFAPSPTGFLHIGGGRTALFNWLYARKHGGTMLLRIEDTDRQRSTQEAIDAILDGLKWLGIDWDGATVYQFARAARHREVAEQLLAAGKAYRCYATAEELTAMRDKARAEGRAKLYDGSWRDRDPSEAPAGVKPTIRLKAPLTGETVIEDQVQGRVAWQNENLDDLVLLRGDGTPTYMLAVVVDDHDMGVTHVIRGDDHLINAARQKQIYDAMEWELPVMAHIPLIHGPDGSKLSKRHGALGVDAYRAMGYLPAALRNYLVRLGWSHGDQEIFTTQEMIDAFDLPAIGRSAARFDFAKLESLNGHYIRQSDDHSLVTLLEDLLKYIPQGPAIAAKFDDSIRAKLTQAMPGLKERAKTLIELLDNAGFIFADRPLALDPKAQAVLTPETRQLIGRLRAALEDVSPWTAATTEAAMRAFAEQAGLKLGAVAQPLRVALTGRTTSPGIFDVLAVLGRDECLSRLADQSA
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_HALSA
Sequence: MRIAVPNKGRLHDPTLALLDRAGIGVEDGADRQLYADTVDPALTVLYARAADIPEYVADGAADAGITGHDQLRESDVDCVEERLDLNYGSCRLVLAAPEDGDVTAPADLDGATVATEFPTITRAYFADTTATPEIVEVTGATELTPHVEMADAIVDITSTGTTLRVNRLQVVDEVLSSSVRLFAHEDVHDDPKVQQVETALRSVLDAHGKRYVMLNAPADRLDDVKAVLPGLGGPTVLDVDEPGTVAVHAVVPERDVFEAISELKAVGASGILVTEIERLVD
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_RIPO1
Sequence: MTMTNDPVVIMKQEVGKAAASRVKSDSIVGLGTGSTTAYAIEYIGERLKSGDLKNIVGVTTSFQAEVLARKYGIPLTTLDVIDRIDVAIDGADEVDPNKNLIKGGGAAHTQEKIVDSLAEVFIVVVDSNKLVDKLGSTFLLPVEVIPKAVTPVMRQLEQLGGKPELRMGVRKAGPVVTDQGNLVIDVKFEGIDDPATLEKTINNIPGVLENGLFVGVTDIVLVGEIIDGKPSVREIC
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: HIS1_ECOLC
Sequence: MTDNTRLRIAMQKSGRLSDDSRELLARCGIKINLHTQRLIAMAENMPIDILRVRDDDIPGLVMDGVVDLGIIGENVLEEELLNRRAQGEDPRYFTLRRLDFGGCRLSLATPVDEAWDGPLSLNGKRIATSYPHLLKRYLDQKGISFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRDGEMEESKQQLIDKLLTRIQGVIQARESKYIMMHAPTERLDEVIALLPGAERPTILPLAGDQQRVAMHMVSSETLFWETMEKLKALGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX1_CANGA
Sequence: MVQRWLYSTNAKDIAVLYFMIALFSGMAGTAMSMIIRLELAAPGSQYLAGNNQLFNVLVVGHAVLMIFFLVMPALIGGFGNYMLPLMIGASDMAFPRLNNVGFWLIVPALVCLVTSTLVEAGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGSINFIVTTLNMRTNGMTMHKLPLFVWAIFITAFLLLLSLPVLSAGVTMLLLDRNFNTSFFEVAGGGDPILYQHLFWFFGHPEVYILIIPGFGIISHIVSTYSKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLATIYGGSIRLAVPMLYAIAFLFLFTIGGMTGVALANASLDVAFHDTYYVVGHFHYVLSMGAVFSTIAGYYYWSPQILGLYYNEKLAQIQFWLIFVGANVTFMPMHFLGINGMPRRIPDYPDAFAGWNYVASVGSFIAMISLVLFIYILYDQFVNGLTNKANNKSVLYTKSPDFVESNEIFNLNTIKTSSIEFLLTSPPAVHSFNTPAVQS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SURE_METAR
Sequence: MTYRILITNDDGVASPGLMAVYEAVRSLGEAVIVAPASQQSAVGRSMTLFEPLRIEKMNLQGTMAYAVNGTPTDSVIMGMYVVMADRKPDLVISGINIGENLSAEAVTTSGTIGAAMEAANQGVPAIAVSMHVLEEADKFATAAMAQDYAVAQRLIGKLARQVLENGLPEGVDLLNVNIPAGATPETPVVVTRLARRMYDTIVHHRMDPRGRSYYWVDGTIVADAPEGTDLHTVHQRRQVSITPLRLDMTACEQTVEIERIIRDNW
What is the function of this protein?
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
What are the official names of this protein?
5'-nucleotidase SurE, Nucleoside 5'-monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SC23A_PONAB
Sequence: MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDSPPIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAGISELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPVTQATRGPQVQQPPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGGRGAIQFVTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETFSLYPQFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA
What is the function of this protein?
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER).  The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.  Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane.
What are the official names of this protein?
Protein transport protein Sec23A, SEC23-related protein A.
What is the protein family that this protein belongs to?
Belongs to the SEC23/SEC24 family. SEC23 subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Note=Enriched at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER).
Protein: DOX1_ARATH
Sequence: MKVITSLISSILLKFIHKDFHEIYARMSLLDRFLLLIVHGVDKMVPWHKLPVFLGLTYLEVRRHLHQQYNLLNVGQTPTGIRFDPANYPYRTADGKFNDPFNEGVGSQNSFFGRNCPPVDQKSKLRRPDPMVVATKLLGRKKFIDTGKQFNMIAASWIQFMIHDWIDHLEDTHQIELVAPKEVASKCPLSSFRFLKTKEVPTGFFEIKTGSQNIRTPWWDSSVIYGSNSKTLDRVRTYKDGKLKISEETGLLLHDEDGLAISGDIRNSWAGVSALQALFIKEHNAVCDALKDEDDDLEDEDLYRYARLVTSAVVAKIHTIDWTVQLLKTDTLLAGMRANWYGLLGKKFKDSFGHAGSSILGGVVGMKKPQNHGVPYSLTEDFTSVYRMHSLLPDQLHILDIDDVPGTNKSLPLIQEISMRDLIGRKGEETMSHIGFTKLMVSMGHQASGALELMNYPMWLRDIVPHDPNGQARPDHVDLAALEIYRDRERSVPRYNEFRRSMFMIPITKWEDLTEDEEAIEVLDDVYDGDVEELDLLVGLMAEKKIKGFAISETAFYIFLIMATRRLEADRFFTSDFNETIYTKKGLEWVNTTESLKDVIDRHYPDMTDKWMNSESAFSVWDSPPLTKNPIPLYLRIPS
What is the function of this protein?
Alpha-dioxygenase that catalyzes the primary oxygenation step of a variety of 14-20 carbon fatty acids, containing up to three unsaturated bonds, into their corresponding 2R-hydroperoxides (PubMed:12060227, PubMed:10455113).  Involved in the production of oxylipins that function in cell signaling, wound healing, and protection from infection (PubMed:12060227, PubMed:10455113).  Mediates protection against oxidative stress and cell death, probably by generating some lipid-derived molecules (PubMed:12060227).  Promotes local and systemic plant defense in a salicylic acid (SA)-dependent manner, including the establishment of systemic acquired resistance (SAR) in response to incompatible interaction (PubMed:22199234).  Involved in a negative regulation of abscisic acid (ABA)-mediated signaling pathway (PubMed:22199234).
What are the official names of this protein?
Alpha-dioxygenase 1, Alpha DOX1, Fatty acid dioxygenase AlphaDOX1, Pathogen-induced oxygenase, Plant alpha dioxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family.
What are the subcellular locations of this protein?
Lipid droplet. Note=Localizes on the surface of leaf oil bodies.
Protein: SYN_STAAE
Sequence: MKTTIKQAKDHLNQDVTIGAWLTNKRSSGKIAFLQLRDGTGFMQGVVVKSEVDEEVFKLAKEITQESSLYVTGTITEDNRSDLGYEMQVKSIEVISEAHDYPITPKNHGTEFLMDHRHLWLRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFLSQSGQLYLEAAAMAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTNHAESLEIQEQYVTHVVKSVLENCKLELKILERDTSKLEKVATPFPRISYDDAIEFLKAEGFDDIEWGEDFGAPHETAIANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAPEGYGEIIGGSERVDDLELLEQRVKEHGLDEEAYSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAPFPRLLNRLYP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCU_MOUSE
Sequence: MAAAAGRSLLLLLCSRGGGGGAGGCGALTAGCFPGLGVSRHRPHQQHRTAHQRPASWQSVGAAYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHEDAATLNDVKTLVQQLYTTLCIEQHQLNKERELVERLEDLKQQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKE
What is the function of this protein?
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685886, PubMed:23900286, PubMed:24212091).  Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity).  Activity is regulated by MICU1 and MICU2 (By similarity).  At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (By similarity).  Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity).  Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity).  While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:26119742, PubMed:26119731, PubMed:25603276).  Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731).  Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity).  Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (PubMed:25732818).  Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (PubMed:26644474).  Involved in antigen processing and presentation (PubMed:25251370).
What are the official names of this protein?
Calcium uniporter protein, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the MCU (TC 1.A.77) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: HRG5_CAEEL
Sequence: MSSKISSSRCCTLFCHVNTRIALTILDILIGFSNILSYAIQFHNWSALTLTAMVTLVACHTLQMFLAEKKNTITHWKYSTFKWIMWIDITLGFLALGCFVVCFIIAGVTEIEFTNLYGENLWFTGLWATAITKYTWQNALLARNYSNQKRILKSEIVEDA
What is the function of this protein?
Heme transporter.
What are the official names of this protein?
Heme transporter hrg-5, Heme-responsive gene 5 protein, CeHRG-5.
What is the protein family that this protein belongs to?
Belongs to the HRG family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RSMH_BACC7
Sequence: MFNHVTVLLKETVDGLDIKPGGTYVDCTLGGGGHSSYLLSQLTEGGRLIAFDQDEIAIQNAKEKFSSYGEQFITVRSNFRYLSEKLQELGITEVDGILFDLGVSSPQLDTPERGFSYHHDAPLDMRMDQDAPLTAYDVVNSWSYEQLVRIFFQYGEEKFSKQIARKIEAYRENKAIETTGELVELIKEGIPAPARRTGGHPAKRVFQAIRIAVNDELKVFEEALESAIEMVKPGGRVSVITFHSLEDRICKTTFKRNSTTPQLPPGLPIIPDEFKPKLKLITRKPILPSDIELEENNRARSAKLRIAEKR
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRF_BRUME
Sequence: MTTELHDDASGRLIVGLDVPTIAEAEKVVEELGNAVSFYKIGYQLVFAGGLDFAKSLVAARKKVFLDMKLLDIDNTIAKGVENVAKMGVSMLTLHAYPKAMRAAVEAARGSDLCLLGVTVLTSMDNADLREAGYFDNAETLVLKRARQAHEAGMGGIVASAVEAQAIRQAVGPDMAIVTPGIRPAGSEKGDQKRVMTPADALRAGASHLIVARPIVGAPDRKAAALAILKEMRSIGRS
What is the function of this protein?
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 1 subfamily.