PharMolix/UniProtQA huggingface dataset:
Protein: ILVC_DEHMB
Sequence: MAVIYYDKDCDLSLIEKKLIGIVGYGAQGHAHAQNLRDSGLKVIVACVEGGRGWKKATADGFEVMCVAEMAKKADIIMMLAPDTSQAKIYKDSVEQGLKPGKMLMFAHGFNIHYGQIVPPSFVDVTMIAPKCPGYMLRQVFTEGAGAPSLIAVEQDASGKAKELALAYAKGIGSNRAGILETTFAEETETDLFGEQAVLCGGTTSLVKAGFETLVEAGYQPEVAYFECLHELKLIVDLMYQGGIAYMRDSISDTAKYGDFTRGPRVINEDTYETMGEILGEIQDGSFAKEWILENQAGRPVYNSLRRMESEHLIEEVGAELRSMMSWLKKKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: PREU5_PREIS
Sequence: MTTNDTPIAIIGLSYRAPGVGRKGLWEYLSQARSAWTTVPTDRFDHSAYYKAGADRSGVSRVRGAHFIDDVYGFDAAFFNMRAEEAKNSDPQHRLLLECALEAAEDAGHSLLSIAGKKIGVFVGSGQHEYSQRLGDDEFATHTFAGTGVAPCMAANRISYFFDIDGPSVVTDAACASSVYAAHVAVSALRNGDCEAAFIGSASLNIGPGGWIVLEKTGALSEHGRSYSYDEKASGFGRGEGAGCLLVKRLDDAIRDGDPIRALIRNSACNHSGRSEGITMPNGLAQQKLLWNVHNAVGLHPGETPVVEGHGTGTAAGDPIEAGAFTAVLGKDRTAENPLYLGSIKSNFGHLEGASGMLAMVKAIMMVENGIVLPTAGFEKINPKIKDAEKIKVAETPLPWPKGEKKRAIVTNFGFGGSNSAIVIEKAPSRDELGHETNGTNGVSVSNGVNGSNGFTNGSNGTNGHAENGNGISAQERRLYTFSAKTEKSLNAYLSSFDEYLDEAPEDSDFAKDLSYTLGQRRTQHPYRVSVVADSVEDLQEKLSTVKPSRIKDRVIAFVFTGQGAQYAQMASELGHFKVFASALKDADAQLKAIGASWSLVSELAKPAEESRVDVAEISQPACTAVQLALVELLKSWGITPTAVTGHSSGEIGAAYAAGLITFRTAIAVAYFRGQAAALLAHKQTSKGAMLALGVGFEEASALIKEHSGDAYATVAAINSPKSVTVSGDVAALEAIHKVAEEQGLFARRLKIEMAYHSRHMEAVADYYLKAIAPFCEKNESFVSKSNAARPIFVSSVTGHVEDNSVVDATYWVKNLLQPVRFADSISGLFTQLGEDKSKIPNVIVEVGPHAALKSPIKQTVESLQLQGKSAFTYLPSLVRNVDGDQALLDLAGSLFTMGAPIQLGGVNQTDSKNAQVITGLPAYEWDKSAHYELKPRPTHEKLFPGEEYHELLGRRVVSNGGKERAWRQVFTLDEMPWIRDHVVAGATIFPMTAYMSAAIEACRRTLPVSSPASAFLVQNFHVVRSMEIAEEESVELMTKLVPAATGEGTTSSTAWAFEISTYKEESGWTIHAYGQIEPEFADMSLETPTFKASLPLVDTTADLLEHDIEGTYASAGVRATRYGPTFRNNVRFWEGKGYTVLEHRLRDLGQALHEPVTRGSPVSVDPPTLDGFLQGGGPLQVDEDGRRPAQMPNYINRFRVSNKIPSDPQTRFDVVMRRLDYDVKGGRMHVGVAAFARNTDGTLSPIAEWESAAFRNIGSADENIDPASDVPDNWAWEKLPRYDFLSLEELRKTLSVGSLGEEEGIRSTNLEKAAVWYIGQALKKTVNDDFSELEDHLQRFLVWAKKTEAEYHTKFDEEPTELLQQVRDHDAQGALLCFIGEQLVPILRGEVEALEIMLAEGRLTKHYEADVVNAHLSQAVGDLADNLSNLEPSLKILEVGGGTAGTTLPILEALSRGRDEPGFLNYTFTDISAGFFEGSRQKLAKWQSRITFKKLDITKDPIDQGFSASDFDIVIAANVLHATPDMVQTMTNVRTLLKPGGKVFLLEANMHPPSVLPFSLLPGWWAAEDKYRDHAEGPMMPVKVWDQLLLDSGFSGVDVAIPGVWDSEVQLMSIMASTKIAQQEGKITICGASLDDKEIAFAKNVDDALSKHLDCKTEVKPYNTISPDDELTYIIFIDSQDHSVMLNPTPEIFKNVQKMLLHNSGLIWVVPEGASPDAHMIKGLMRTLRLEEAPKNLMVFDEVPLTPVGLKGIVKLAESLRNPEVRRDEDQDFHLHNGTIHLPRMRQLNEVKELFAVEQGIAYRKVQNIWEGGRALEMTIDAAGSPDSIYFRRTNVLQQPMGDDEVLIRVEAAGVSNRDLNLVLGSIPWAPPGYDGAGKVVKTGSHVSHLREGDDIFFLALESSAFATYKKMPAWHVAKIPSGLSITDASTLPLAYTLAVLGLIRTARLRKSDTILIHGAAGAVGQASIAIAQHIGATIFATAGTEAKREFIHQAFGIPKERIFTSRTAAFRDSILSATDNKGVNVIINSLGSEFITETWALAAKFGRFVEISKEAAFQNINLPMRAFDSNVTFSPVDIRELYKHQPDELRDVWSEVVDLLKRDVVKPIKPVTLIPISDFVSALRKLKSGDHLGKIVVTLGKDEKVVAESALSPTEVKLRTDGTYLVTGGTRGIGLDLAYWMIEHGAKNIVLLGRSGATGEEVKKMLKRYEGNDVTIRALACNVGIRDELVNVMEAIKDLPPVRGVVHSALLLSDKLFANSTHEDWQIVNTPRVQGAWNLNELLPADLDFFVLLSSFNGDTGNMGQAIYAGTAGFYDAFSRYRNARGQHTVSIALPIVLDVGYVADNNLTEILKQTLGVVLKMADIRALFKGAVSGPASPFHSNGKATAFKLYMEGQSLQNPPWKYFHPVHTRERLKADKDARLKAGATGGADMFTASWTTAEDPLEGLTEALITKVSAMTMIERDEVLPDAPLTSYSLDSLVSVELRNWIRRETTVELPLSSITQAESLRALATDILSQRVI
What is the function of this protein?
Highly reducing polyketide synthase; part of a gene cluster that mediates the biosynthesis of a yet unidentified natural product.
What are the official names of this protein?
Highly reducing polyketide synthase Preu5, HR-PKS Preu5.
Protein: KXD1_YEAST
Sequence: MVTGISEENDDEETFSAVHSSTPSINSQSYAIPITEEMSSSFHDSISTTSNSSGSFDSDGSNVSDVVEQNEMDNESNVDEDLFLDNDIPQSSNLLPTDAQDPGPIFDVSRYIFDSLKQSIDSADFSEALSLQTKTSAVINSKSLELKQYIDEMKSRLTQLQEKFENGEATSKKIKRDLETSRKNIDYLNAALRVDFPIEFNQAREKILERRLNEDHDC
What is the function of this protein?
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
What are the official names of this protein?
Biogenesis of lysosome-related organelles complex 1 subunit KXD1, BLOC-1 subunit KXD1, KxDL homolog.
What is the protein family that this protein belongs to?
Belongs to the KXD1 family.
What are the subcellular locations of this protein?
Endosome.
Protein: MGR1_PICST
Sequence: MGVYIPPPNDNDSDKDKKKNKNNDNPNLNPEPSGDSKKVNNVIKGVSSTSPPGTTTYYIPNPSTWIPHNPSAGLIWGPLTPSSDNRPALYGMVGLQFILGLGFFRAARQLYRPRTIVTSVNSIPQHFTPKGSFWKASIPALTGAVAIYGCGLELSRLMLAYDPWYEEAKYYRRVAIKNGDKPSAWFGAYDYYKPMSTKAWIDKVGIWIKATEHELSEKQEVLDVSIVQANSSNPDDKGHVEHVLIPVKKNNLMSQMNKKGKYVEIYNRLRESNKSRYRTLLDTDLKDVQELNKAERIDLILEGKSPYSNPEYTKPHIQLGNHHVDTDDEFEMVWLNFEPWDELKLETDYDIRLIPHWRWADSDNSEPELDAVEQQHNHSISEAESSKELV
What is the function of this protein?
Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.
What are the official names of this protein?
Mitochondrial genome required protein 1.
What is the protein family that this protein belongs to?
Belongs to the MGR1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS12_RHOJR
Sequence: MPTINQLVRKGRRDKTAKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSSVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKGRKQARSRYGAKKEKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: DAPA_NEIMF
Sequence: MLQGSLVALITPMNQDGSIHYEQLRDLIDWHIENGTDGIVAVGTTGESATLSVEEHTAVIEAVVKHVAKRVPVIAGTGANNTVEAIALSQAAEKAGADYTLSVVPYYNKPSQEGMYRHFKAVAEAAAIPMILYNVPGRTVVSMTNDTILRLSEIPNIVGVKEASGNVGSNIELINRAPEGFVVLSGDDHTALPFMLCGGHGVITVAANAAPKLFADMCRAALQGDIALARELNDRLIPIYDTMFCEPSPAAPKWAVSALGRCEPHVRLPLVPLTEGGQAKVRAALKASGQL
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTCA_DESA1
Sequence: MSILEIDGSIGEGGGQILRYALALSALTLKPIRVYNIRAKRDNPGLRPQHLTAVEVLKEVTGAEVENAKVGSMEILFKPTSRRSGEMEIDIGTAGSISLVLQAMLPVLLFAEGDSRARLKGGTNVPWSPPIDYIKHVFLYNISHMGVRANIEVVRRGHYPRGGGLVNVEVKRVEEALKPLMIVRRGRIRGFRIHSHCVKLPAHVAVRQCESARRILSGIFKEKITEEIETYPPDKDPHLGPGSGILIYVEAEPGIRLGSDSLGEKGKPAERVGEEAALILIEELETGMAFDRHMGDMLIPYLFLAKGTSRIGVSMITLHLLTAIEVGKLFFPEAKVEVDGELGKPGIITIQGVGYKP
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: WCAL_SALTY
Sequence: MKVSFFLLKFPLSSETFVLNQITAFIDMGHEVEIVALQKGDTQHTHAAWEKYGLAAKTRWLQDEPQGRLAKLRYRACKTLPGLHRAATWKALNFTRYGDESRNLILSAICAQVSQPFVADVFIAHFGPAGVTAAKLRELGVLRGKIATIFHGIDISSREVLSHYTPEYQQLFRRGDLMLPISDLWAGRLKSMGCPPEKIAVSRMGVDMTRFTHRSVKAPGMPLEMISVARLTEKKGLHVAIEACRQLKAQGVAFRYRILGIGPWERRLRTLIEQYQLEDVIEMPGFKPSHEVKAMLDDADVFLLPSITGTDGDMEGIPVALMEAMAVGIPVVSTVHSGIPELVEAGKSGWLVPENDAQALAARLAEFSRIDHDTLESVITRAREKVAQDFNQQAINRQLASLLQTI
What are the official names of this protein?
Putative colanic acid biosynthesis glycosyltransferase WcaL.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: EFG2_BURO1
Sequence: MARKTPIERYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWKGMGGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYKVPRLAFVNKMDRTGANFFKVYDQLRLRLKANPVPVVVPIGAEENFKGVVDLIKMKAIIWDEASQGTKFDYVDIPAELAETCKEWREKMVEVAAEASEDLMNKYLEEGDLPEADIVKALRDRTIACEIQPMLCGTAFKNKGVQRMLDAVIDFLPSPVDIPPVKGELENGEEAERKASDEEKFSSLAFKIMTDPFVGQLIFFRVYSGVVNSGDTLLNSTKGKKERLGRILQMHANQREEIKEVRAGDIAAAVGLKEATTGDTLCDPANPIVLERMVFPEPVISQAVEPKTKADQEKMGLALNRLAQEDPSFRVQTDEESGQTIISGMGELHLEILVDRMKREFGVEATVGKPQVAYRETIRSTAKDVDGKFVKQSGGRGQYGHAVITLEPNEQGKGYEFFDEIKGGVIPREYIPAVDKGIQDTLKSGVLAGFPVVDVKVHLTFGSYHDVDSNENAFRMAGSMAFKEAMRKANPVVLEPMMAVEVETPEDYMGNVMGDLSGRRGIVQGMEDMVGGGKIVRAEVPLSEMFGYSTSLRSLAQGRATYTMEFKHYAEAPRNVAEAIISAKSK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G 2, EF-G 2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Protein: RECF_MYCPA
Sequence: MYVRHLGLRDFRSWAHADLELQPGRTVFIGSNGFGKTNLLEALWYSSTLGSHRVGTDAPLIRAGADRAVVSTIVVNDGRECAVDLEIAAGRANKARLNRSPVRSTREVLGVLRAVLFAPEDLALVRGDPSERRRYLDDLATLRRPAIAAVRADYDKVLRQRTALLKSLSGARHRGDRGALDTLDVWDSRLAEYGAQLMAARIDLVNQLAPEVEKAYQLLAPGSRAASIGYRSSLGAAASAEVNAGDRDYLEAALLAGLAAHRDAELERGMCLVGPHRDDLELWLGEQVAKGFASHGESWSLALSLRLAAFELLRADESDPVLLLDDVFAELDAARRRALAAVAESAEQVLVTAAVLEDIPTGWQARRLFVELRDTDAGRVSELRP
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP (By similarity).
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCSB_DESRM
Sequence: MSLKETVSNPYSKWLEATGPENDVIISSRVRLARNLMGYPFPHVLGHENADKVLYAVQSAVAQKSLQEAVGNLELSRMTELSSIERQILVEKHLISPDMLEQPEKRGVVLRDDEVISIMVNEEDHLRIQCLLPGLQLKECWDLANTVDDGLEQIIDYAFAKEQGYLTSCPTNIGTGLRASVMLHLPALVMTRQINAVLTTLSKLGLTVRGLYGEGTQATGNLFQVSNQVTLGLTEEEIIDNLITVALQLVTQERAARRALHKEQLHQIEDKVWRAYGLLKYARTMTSNETMTLLSDMRLGVDLGVITGIPPGIIMELIILSRPAFLSKVKGADLNPYQRDIFRATLIRERLNSLSNE
What is the function of this protein?
Catalyzes the specific phosphorylation of arginine residues in proteins.
What are the official names of this protein?
Protein-arginine kinase.
What is the protein family that this protein belongs to?
Belongs to the ATP:guanido phosphotransferase family.
Protein: RPIA_SHIDS
Sequence: MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKSLGIHVFDLNEVDSLGIYVDGADEINGHMQMIKGGGAALTREKIIASVAEKFICIADASKQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQGVVTDNGNVILDVHGMEILDPIAMENAINAIPGVVTVGLFANRGADVALIGTPDGVKTIVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: EFCB8_HUMAN
Sequence: MSSEDLAEIPQLQKLSIPHGFQNKEAASSPTPSITLSQVPDLQPGSQLFTEIHLAKIEKMFEEDINSTGALGMDAFIKAMKKVLSSVSDEMLKELFLKVDSDCEGFVTWQKYVDYMMREFQGKEDMRKSQYRLHFYLPMTVVPL
What are the official names of this protein?
EF-hand calcium-binding domain-containing protein 8.
Protein: RP19_MONPV
Sequence: MADTDDIIDYESDDLTEYEDDEEDGESLETSDIDPKSSYKIVESTSTHIEDAHSNLKHIGNHISALKRRYTRRISLFEIAGIIAESYNLLQRGRLPLVSEFSDETMKQNMLHVIIQEIEEGSCPIVIEKNGELLSVNDFDKDGLKFHLDYIIKIWKLQKRY
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase 19 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 19 kDa subunit family.
Protein: Y136_ELUMP
Sequence: MADYSFDIVSKVDTNLIEESISVALKEITNRYDFKDSNSSMELNTKDNEIKLSSADDFKVKSLYDILLTRLSKRGISLKNFQPGKIESALGGTAKQSVKIQQGIPADKAKEIVRIIKDAKIKVNASIQGDQLRVTSKSKDDLQATMALLKGKDLGLDLQFTNYR
What are the official names of this protein?
UPF0234 protein Emin_0136.
What is the protein family that this protein belongs to?
Belongs to the UPF0234 family.
Protein: EFHB_HUMAN
Sequence: MNMEIGHPHEGKDDLGDKRVIMGTKFPMELGIRVGLGKEDSRCGESPVVSNKCEGRMAPPETKFPLSKGLEMGLERQNISRTVMQRGSLGVDSVSASQGTKPSLLPGRMGLENESLLAGYTHERIIQPPLGRVCGSSQAAGSRRAPLASGPEGVEELVGKPAFVMEPRQEMEKESTCVLMKPNTEIKLPVEVDIGLTQAEGPDETKNTEPQMGLVIEPPQCQFAQQHEQRKEAGNIESGVEPPDRIRPIYSGKFFDRTPCWPSAGKVIPVGYRVATCLTEKLPRLITPPEAKKYFNFRYPPAGVERVFYGRANDPQIAPYLTHGIRSKISVLANTLINPQPITTFQQKIKDKKESIYLSNRRAPLGKSHDQAPGLPKGMDTTNTTFGTAVIKEYSAKDVVNPPKSYEEVFKEGNEGHDLYVVSHNDYYAGEAKNRKYNPSSFHRCSVYGVPTPHFNDGRAMAKSLYWLHELQMKRGAKFVSKRADDFKEKFQHKLGRVLDPIAETMNVPPDCTFGACLRPEEYGVGDLIHNRLPDEYLRGKDRQRALIAAVRHHLKKVNYQKFDTLLAAFRHYDKKGDGMIDKDELQEACDQANLSLDDKLLDQLFDYCDVDNDGFINYLEFANFLNWKDKMLLKEYEERVIIKGRKPDCVNPTEANVEEPEQTLLIKPEDIVLKEAGSTEKTLRTLLRPSDKVSNYYKTTSSEINAIVGAIPSTCYPICGVPTIRSDIPAPRIRRISDRTNYGEEGSAYSLLYPTIFARKGVFERDFFKTRSKEEIAEILCNIGVKLSDEEFENVWNLASKKHHRGEVCVENIRNVLDELRHADRIKCKTLM
What is the function of this protein?
Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (PubMed:30481768).  Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).
What are the official names of this protein?
EF-hand domain-containing family member B, Cilia- and flagella-associated protein 21.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme.
Protein: FTHS_LIMRD
Sequence: MTDIEIADQATLEPITEIAEKLGLSEDEIEQYGKYKAKIDLNVKPLPDKKHKLILVTSINPTPAGEGKSTVLIGLGDALNQLNYQTTIAMREPSMGPVFGIKGGATGGGYSQVVPMEDINLNFTGDLHALTSANNTLAALIDNYIMRDNAMNLDPRRIIWKRVEDVNDRALRNVVTGLGGPMAGVPRETGFDITAASELMAILCLSTSLHDLKERISRIVVGYTYDKEPVTVGQLNFQDAITIILKDALKPNLVQTLDHTPTIVHGGPFANIAHGCNSVLATQTALNLSDYTVTEAGFGADLGGEKFLDIKQRVLGKHPDAIVIVATVRALEYNGGAKLADLNEENLDALKKGMANLNRHIKNMQLYGLPIVVAINHFVSDTDKEIQMIKDDCAKQNVEAILTDAWAKGGKGTHDLANKVVELADSPSEFTHIYDVQVDDLQTKLEKIAKQIYGAKEVSFSRKAQNQLKRFAKYGWNDLPVCIAKTQYSFTDDQKQLGAPTDFTFHIRELVPKIGAGFVVALAGNMMTMPGLPKEPAAVNMMIDDNGKITGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: AUX22_SOYBN
Sequence: MAKEGLGLEITELRLGLPDAEHQVSVVNKKNEKKRAFSEIDDGVGDENSSSGGGDRKMETNKSQVVGWPPVCSYRKKNSMNEGASKMYVKVSMDGAPFLRKIDLGLHKGYSDLALALDKLFGCYGMVEALKNADNSEHVPIYEDKDGDWMLVGDVPWEMFMESCKRLRIMKKSDAKGFGLQPKGSLKGFIESAAK
What is the function of this protein?
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.  Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE).  Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression (By similarity).
What are the official names of this protein?
Auxin-induced protein AUX22.
What is the protein family that this protein belongs to?
Belongs to the Aux/IAA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: AROE_STAAS
Sequence: MKFAVIGNPISHSLSPVMHRANFNSLGLDDTYEALNIPIEDFHLIKEIISKKELDGFNITIPHKERIIPYLDHVDEQAINAGAVNTVLIKDDKWIGYNTDGIGYVKGLHSVYPDLENAYILILGAGGASKGIAYELAKFVKPKLTVANRTMARFESWNLNINQISLADAEKYLAEFDIVINTTPAGMAGNNESIINLKHLSPNTLMSDIVYIPYKTPILEEAERKGNHIYNGLDMFVYQGAESFKIWTNKDADINSMKTAVLQQLKGE
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: CYYR1_HUMAN
Sequence: MDAPRLPVRPGVLLPKLVLLFVYADDCLAQCGKDCKSYCCDGTTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNHRATRVGILRTTHINTVSSYPGPPPYGHDHEMEYCADLPPPYSPTPQGPAQRSPPPPYPGNARK
What are the official names of this protein?
Cysteine and tyrosine-rich protein 1, Proline-rich domain-containing protein.
What is the protein family that this protein belongs to?
Belongs to the CYYR1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: FEN_METS3
Sequence: MGVKLKDIIQPEQIDFKDLKGRAISIDAFNTLYQFLSTIRQRDGRPLSDSNGNITSHLSGILYRNSSMIEKDIKPIYVFDGTPSYLKQETIDQRRQTREESEKKWKEALAKQDTQEARKYAMRSSKLSPYIIESSKKLLTMMGIPYIEAYGEGEAQAAYLVENGDAWAVASQDYDCLLFGAKRVVRNLAINSNLGDLEYYNLKRVLDELDINREQLIDMGILIGTDFSEGLKGVGAKTALKLAKKGELENKLAKLQEESSHDISEVREIFLNHNVNTNYKIRWKKPAKNDIIDFLCEEHGFSQDRVSKACDKLKNLNSSQKSLEDWF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: ILVD_MACCJ
Sequence: MRSNMIKKGPEQAPARSLLHATGQIKSPEDMNKPFIAICNSYIDIVPGHVHLRELADIAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADAAETVINAHWFDGVFYIPNCDKITPGMLLAAVRTNVPAIFCSGGPMKAGLSATGKALTLSSMFEAVGAFKEGTLTKEDFLDMEQNACPTCGSCAGMFTANSMNCLMEVLGLALPFNGTALAVSKERRALIRESAFKLMDLVKRDIKPKDIVTKEAIDDAFALDMAMGGSTNTVLHTLALANEAGIDYDLERINEIAEKTPYLSKIAPSSSYSMHDVHTAGGVPAIINELMKREGILHPDRMTVTGDTLRDNNAAYTIQNEEVIHTLDNPYSEHGGLSMLHGNIAPLGGVIKVGGVDPSIQTFTGAAICFDSHDAAVAAIDNHTVRPGHVVVIRYEGPKGGPGMPEMLAPTSSIVGRGLGKEVALITDGRFSGATRGIAVGHISPEAAALGPIALIEDGDMVTIDLVHRTLNVDVTDDELKQRKARLQPFKAKVKSGYLARYTALVTSANTGGVMQIPEHLL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: LEPA_STAAC
Sequence: MDNEQRLKRRENIRNFSIIAHIDHGKSTLADRILENTKSVETRDMQDQLLDSMDLERERGITIKLNAVRLKYEAKDGNTYTFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNELELLPVINKIDLPAAEPERVKQEIEDMIGLDQDDVVLASAKSNIGIEEILEKIVEVVPAPDGDPEAPLKALIFDSEYDPYRGVISSIRIVDGVVKAGDKIRMMATGKEFEVTEVGINTPKQLPVDELTVGDVGYIIASIKNVDDSRVGDTITLASRPASEPLQGYKKMNPMVYCGLFPIDNKNYNDLREALEKLQLNDASLEFEPESSQALGFGYRTGFLGMLHMEIIQERIEREFGIELIATAPSVIYQCVLRDGSEVTVDNPAQMPDRDKIDKIFEPYVRATMMVPNDYVGAVMELCQRKRGQFINMDYLDDIRVNIVYELPLAEVVFDFFDQLKSNTKGYASFDYEFIENKESNLVKMDILLNGDKVDALSFIVHRDFAYERGKALVEKLKTLIPRQQFEVPVQAAIGQKIVARTNIKSMGKNVLAKCYGGDISRKRKLLEKQKAGKAKMKAVGNVEIPQDAFLAVLKMDDE
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MTXX_METMA
Sequence: MYALLEAIEARARANRARVAMGIRDPNHKTLESAWKAQELGYAQVVLVGSKKEIDKIGTGLEVIDTEDPEKVLSDLLVSRKVDAVIRGTAKASGTLSSLKKALGMKRICRLALLLTADGTPFFLAPVGIDEGNTISDKLRMITLGAEHIRRLGVEPAVGVLSGGRMGDIGRDRRVDRTLADGEFITGRALELGINTKHYTILIEDAVKESNFIIAPDGISGNLIFRTVAFLGGGDGLGAPVLMDDYVFVDTSRVGGHFTKAIMLASALSHLNKERKKVIH
What are the official names of this protein?
Putative methyltransferase mtx subunit X.
What is the protein family that this protein belongs to?
Belongs to the MtxX family.