PharMolix/UniProtQA huggingface dataset:
Protein: NEUG_RAT
Sequence: MDCCTESACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGECGRKGPGPGGPGGAGGARGGAGGGPSGD
What is the function of this protein?
Regulates the affinity of calmodulin for calcium.  Involved in synaptic plasticity and spatial learning (By similarity).
What are the official names of this protein?
Neurogranin, Ng, Protein kinase C substrate 7.5 kDa protein, RC3.
What is the protein family that this protein belongs to?
Belongs to the neurogranin family.
What are the subcellular locations of this protein?
Cytoplasm. Synapse. Cell projection, dendritic spine. Note=Restricted to dendritic spines of a subset of neurons.
Protein: HEMI1_HEMLE
Sequence: MTFLILTILATVTPSLYSHVVQRELRVNFEPLAGQRDSWPVARAAMVTFDARSEKAREFSECRMINSMHELSRELMDSPEHTVKRASKEEMDDLVQRCSGSAEGRSWFIWPDTKWCGPGTDAKNESDLGPLEADKCCRTHDHCDYIGAGETKYGLTNKSFFTKLNCKCEAAFDQCLKESIDRAEGSAKSSMEGLHSFYFNTYSPECYEVKCSRKRDAECTNGIAIWKDSYKS
What is the function of this protein?
Scorpion venom phospholipase A2 (PLA2) that shows high hydrolytic activities towards lecithin and acts as an effective blocker of all angiogenesis key steps in vivo and in vitro (PubMed:26335363).  It has no effect on apoptosis and does not display hemolytic, inflammatory or neurotoxic effects (PubMed:26335363).  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Phospholipase A2 hemilipin, Phosphatidylcholine 2-acylhydrolase, Phospholipase A(2).
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group III subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMC_ECO57
Sequence: MQCALYDAGRCRSCQWITQPIPEQLSAKTADLKNLLADFPVEEWCAPVSGPEQGFRNKAKMVVSGSVEKPLLGMLHRDGTPEDLCDCPLYPASFAPVFAALKPFIARAGLTPYNVARKRGELKYILLTESQSDGGMMLRFVLRSETKLAQLRKALPWLQAQLPQLKVITVNIQPVHMAIMEGETEIYLTEQQALVERFNDVPLWIRPQSFFQTNPAVASQLYATARDWVRQLPVKHMWDLFCGVGGFGLHCATPDMQLTGIEIALEAIACAKQSAAELGLTRLQFQALDSTQFATAQGEVPELVLVNPPRRGIGKPLCDYLSTMAPRFIIYSSCNAQTMAKDIRELPGYRIERVQLFDMFPHTAHYEVLTLLVKM
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: RL27_SYNSC
Sequence: MAHKKGTGSTRNGRDSNAKRLGVKAYGGETVTAGSILIRQRGTSVLPGVNVGKGKDDTLFALTDGIVKFESIRRGLRNRKRINITATA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: GATE_METJA
Sequence: MEINYEKVGLKVGLEIHQQLNTKRKLFCHCPTILRDDEPDGEIVRVLRPSLSEMGEVDRAALIEARKGKKFIYQFYNDTTCLVELDEEPPHPPSEEALRIALEVALLMNMNVVDVAYTMRKIVIDGSNTSGFQRTIFLARDGYIETSEGKVGITSLCLEEDAARKIEDRGDAVVYNLDRLGIPLVEISTAPDIKTPKMAKEAARRIGEILRATGKVKRGLGTIRQDINISIKDGARIEVKGVQDLDLIEKVVENEVIRQLNLLKIRDELRERNAEVVEKIFDVTEIFKDCKSKIIQNALKKKNGKVKAVLLKGFAGLVGKEIQPGRRLGTEFSDRAKVIAGVGGLFHTDELPKYGITEEEVKKLKEFVNAEENDAVIIVADEESKVDRALEAVIERAKEALIGVPEETRRALEDGNTAYLRPLPGAARMYPETDIPPIIIKKEFIEEIRANLPELPEEKFERFKKEYKLNDELAKKMVLSYYVDLFEDLCKKFKNVKPVLIATTLEGTLKEIKREGYDIDKLEDRHLEETFKALSEGKIAKEGIVEVLKGFCEFPDKSIDEILEIKGLKGLSKEEVEKIIEGIIKEHLNVVKEKGEKAYGFLMGRCMAKLRGKADGKLVNDILRKKLKEI
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit E, Glu-ADT subunit E.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatE subfamily.
Protein: ALG8_PSEAE
Sequence: MMETYKRGLAEATGWLVFLSLLMVLALAVPKTVFDADSKDFILLIGAVGIWRYSMGGVHFLRGMLFLHVVYPYYRRRVRQLGSAADPSHVFLMVTSFRIDALTTAMVYRSVIREAIDSGYPTTVVCSIVEMSDEVLVRSLWEKMNPPDRVSLDFVRIPGTGKRDGLAYGFRAISRHLPDDDAVVAVIDGDTVLDHGVVKKTVPWFKLFPNVGGLTTNEFCEVQGGYVMSEWHKLRFAQRHINMCSMALSKRVLTMTGRMSVFRARVVTNPEFITDVENDHLEHWRLGRFKFLTGDDKSSWFSLMRLGYDTFYVPDAAINTVEHPPEKSFIKASRKLMYRWYGNNLRQNSRALKLGARRLGWFTMLVLFDQRVSMWTSLLGLVVAILASLKYSIAFLLVYLLWIGLTRLVLTLLLSLSGHRIGPAYPLILYYNQIVGALVKIYVFFRLDRQSWTRQPTKLERGLASFQRWFNAWSSRAMTFSAASIFVAVLLTIV
What is the function of this protein?
Processive enzyme that polymerizes GDP-mannuronic acid.
What are the official names of this protein?
Mannuronan synthase, Glycosyltransferase Alg8.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CB2_DUNTE
Sequence: MAALIARSGLKALNIRQTRQQRMATVPRAAVEFYGPDRAKFLGPFSENDTPEYLTGEFPGDYGWDTAGLSADPQTFARYREIELIHARWALLGALGILTPELLSQYAGVQFGEPVWFKAGAQIFADGGLNYLGNESLIHAQSIIATLAVQVVLMGLAEAYRANGGSEGFLDDLDTLYPGGPFDPLGLADDPDTFAELKVKEIKNGRLAMFSCLGFFVQAIVTGKGPVQNLTDHLADPTVNKAFASATKFTPGV
What is the function of this protein?
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.
What are the official names of this protein?
Chlorophyll a-b binding protein of LHCII type I, chloroplastic, CAB, LHCP.
What is the protein family that this protein belongs to?
Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi- pass membrane protein.
Protein: GARL_ECOLU
Sequence: MNNDVFPNKFKAALAAKQVQIGCWSALSNPISTEVLGLAGFDWLVLDGEHAPNDISTFIPQLMALKGSASAPVVRVPTNEPVIIKRLLDIGFYNFLIPFVETKEEAEQAVASTRYPPEGIRGVSVSHRANMFGTVADYFAQSNKNITILVQIESQQGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPDVQKAIQHIFNRASAHGKPSGILAPVEADARRYLEWGATFVAVGSDLGVFRSATQKLADTFKK
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
What are the official names of this protein?
5-keto-4-deoxy-D-glucarate aldolase, KDGluc aldolase, KDGlucA, 2-dehydro-3-deoxy-D-glucarate aldolase, 2-keto-3-deoxy-D-glucarate aldolase, 5-dehydro-4-deoxy-D-glucarate aldolase, Alpha-keto-beta-deoxy-D-glucarate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Protein: SCN8A_HUMAN
Sequence: MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC
What is the function of this protein?
In macrophages and melanoma cells, may participate in the control of podosome and invadopodia formation.
What are the official names of this protein?
Sodium channel protein type 8 subunit alpha, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Mainly localizes to the axon initial segment. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasmic vesicle. Note=Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.
Protein: SC5A6_HUMAN
Sequence: MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLHCRSYGQDHLDTGLFPEKPRNGVLGDSRDKEAMALDGTAYQGSSSTCILQETSL
What is the function of this protein?
Sodium-dependent multivitamin transporter that transports pantothenate, biotin and lipoate (PubMed:10329687, PubMed:15561972, PubMed:21570947, PubMed:20980265, PubMed:22927035, PubMed:22015582, PubMed:25971966, PubMed:25809983, PubMed:28052864, PubMed:27904971, PubMed:31754459).  Required for biotin and pantothenate uptake in the instestine (By similarity).  Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity).  May play a role in the transport of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983).  May also be involved in the sodium-dependent transport of iodide ions (PubMed:20980265).
What are the official names of this protein?
Sodium-dependent multivitamin transporter, Na(+)-dependent multivitamin transporter, Solute carrier family 5 member 6.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=(Microbial infection) Exposure to E.coli lipopolysaccharides leeds to reduced cell membrane localization.
Protein: TPIS_MYCTA
Sequence: MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAGGPLP
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDCB_PSEAB
Sequence: MNAIANLAATLRADLGECLADLAVDALIDEAELSPKPALVDRRGNGAHADLHLGLMQASALSLWPCFKEMADAAQRHGRIDARLRGVLGQLGRDGEAAMLRTTEGVNTHRGAIWALGLLVAAAALEPRRTQAGEVAARAGRIALLDDPAAAIGDSHGERVRRRYGVGGAREEARLGFPRAVRHGLPQLWRSREGGAGEQNARLDALLAIMSVLDDTCVLHRAGRVGLAAMQDGARAVLAAGGSASLAGRRRLCELDRRLLALNASPGGAADLLAACLFLDRLPAVSGGWAGSL
What is the function of this protein?
Involved in the formation of 2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase.
What are the official names of this protein?
Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase, 2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase.
What is the protein family that this protein belongs to?
Belongs to the CitG/MdcB family.
Protein: AROB_THISH
Sequence: MQTLTVELGDRSYPIHIGRGLLDDPTRFAPRIRGKRVMIVTNETVAPLYLDRLKRTLGDFRVEAVILPDGEEYKTMETLNQVYTALLEARFDRKATLVALGGGVIGDITGFAAASYQRGVDFIQVPTTLLSQVDSSVGGKTGVNHPLGKNMIGAFHQPRCVVIDTDTLDTLPDRELRAGIAEVIKYGLICDRPFFDWLEANMDRLLARDPEALAYAIHRSCHDKAQVVAEDEREGGRRAILNLGHTFGHAIETGMGYGVWLHGEGVATGMVMAARMSRRLGWLDAEDLHRTEALIARAGLPVEPPPEITAERFAELMSVDKKVLDGQLRLVLLRGIGEAVVTADFDPAALDATLNQVGSGN
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_MYCMM
Sequence: MTEFCAPKGVPDYVPPDSAQFVAVRDGLLTAARRAGYGHIELPIFEDTALFARGVGESTDVVSKEMYTFADRGDRSVTLRPEGTAGVVRAVIEHGLDRGALPVKLCYAGPFFRYERPQAGRYRQLQQVGVEAIGVDDPALDAEVIAIADAGFRSLGLDGFRLEVTSLGDETCRPQYRELLQEFLFGLDLDDDTRRRAALNPLRVLDDKRPEVRAMTAEAPVLLDHLSDVAKQHFDTVLAHLDALRVPYVINPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMKQLGGQDLSGIGFGLGVDRTMLALRAEGKSVGESARCDVFGVPLSEQAKLTLAVLAGQLRASGVRVDLAYGDRGLKGAMRAADRSGARVALVAGDRDIEAGTVGVKDLGTGEQVSVSTDSVVDDVISKLGR
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_KLEP3
Sequence: MKFELDTTDGRARRGRLVFERGVVETPAFMPVGTYGTVKGMTPEEVEATGAQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSGGFQVFSLGDIRKITEQGVHFRNPINGDPIFLDPEKSMEIQYDLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRDRFDSLGNKNALFGIIQGSVYEDLRDISVKGLVEIGFDGYAVGGLAVGEPKEDMHRILEHVCPQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTDGVVKIRNAKHKSDTAPLDAECDCYTCRNYSRAYLHHLDRCNEILGARLNTIHNLRYYQRLMAGLRKAIEEGKLESFVTDFYQRQGRTVPPLNVD
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: UCSB_ACRSP
Sequence: MIIQGNQLDSLPKAEDWEAFAESYKRIAEVAVMKPVQALLQCLDDRLPLSGAVGILDNGSGPGIIMSSLIERYGPQLPPDCVLTCVDYAPAMIDQVDKARIKAVEEDADSAWGRVEGKVLDALDLHSIADESQSHIAAGLLYNLTTDPAKCLSECKRTLQPGGVLAVSAWEGNDWIEMLRVVPLIKPDLKTAIQPKWSTVDAVRWDLELAGFREVHVQRIPIKIPFTSHALFVDTLMRYQPRMVAMLRTFTEDEKTELRRLLMNEMKVICPSQPGMMSGAVMVGAGVR
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of UCS1025A, a member of the pyrrolizidinone family that acts as a strong telomerase inhibitor and displays potent antibacterial and antitumor properties (PubMed:29373009).  These compounds share a hemiaminal-containing pyrrolizidinone core fused with a gamma-lactone, giving a furopyrrolizidine that is connected to a decalin fragment (PubMed:29373009).  The polyketide synthase module (PKS) of the PKS-NRPS ucsA is responsible for the synthesis of the polyketide backbone via the condensation of an acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:29373009).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the polyketide with a 2S,3S-methylproline derived from L-isoleucine by the 2-oxoglutarate-dependent dioxygenase ucsF which converts L-isoleucine to (4S,5S)-4-methylpyrroline-5-carboxylate that is further converted to 2S,3S-methylproline by the pyrroline-5-carboxylate reductase ucsG (PubMed:29373009).  Reductive release of the completed aminoacyl polyketide from the assembly line can form the 3-pyrrolin-2-one structure via an intramolecular Knoevenagel reaction (PubMed:29373009).  Because ucsA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase ucsL (PubMed:29373009).  This keto acyclic precursor is the substrate of the Diels-Alderase ucsH, that catalyzes the Diels-Alder cycloaddition (PubMed:29373009).  Oxidation of the 3S-methyl group to a carboxylate by the cytochrome P450 monooxygenase ucsK allows an oxa-Michael cyclization that might involve the reductase/dehydrogenase ucsI and which furnishes the furopyrrolizidine (PubMed:29373009).  The oxidase ucsJ likely plays a critical role in stereoselective reduction of the C5-C6 double bond to afford the required R-configured carboxylate group (Probable).  Further enolization and oxidation at C5 by an unidentified enzyme affords the last intermediate that can undergo oxa-Michael cyclization to yield UCS1025A (Probable).
What are the official names of this protein?
Methyltransferase ucsB, UCS1025A pyrrolizidinone biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily.
Protein: VATB_STRPJ
Sequence: MSVIKEYRTASEVVGPLMIVEQVNNVSYNELVEIQLHNGEIRRGQVLEIHEDKAMVQLFEGSSGINLEKSKIRFAGHALELAVSEDMVGRIFNGMGKPIDGGPDLIPEKYLDIDGQAINPVSRDYPDEFIQTGISSIDHLNTLVRGQKLPVFSGSGLPHNELAAQIARQATVLNSDENFAVVFAAMGITFEEAEFFMEELRKTGAIDRSVLFMNLANDPAIERIATPRIALTAAEYLAFEKDMHVLVIMTDMTNYCEALREVSAARREVPGRRGYPGYLYTNLSTLYERAGRLVGKKGSVTQIPILTMPEDDITHPIPDLTGYITEGQIILSHELYNQGYRPPINVLPSLSRLKDKGSGEGKTRGDHAPTMNQLFAAYAQGKKVEELAVVLGESALSDVDKLYVRFTKRFEEEYINQGFYKNRNIEDTLNLGWELLSILPRTELKRIKDDLLDKYLPLVEV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The V-type beta chain is a regulatory subunit.
What are the official names of this protein?
V-type ATP synthase beta chain, V-ATPase subunit B.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: SECA_ERYLH
Sequence: MFQTLMKSVFGSSNDRYVKSIGKIVDQINALEDQIKALSDEALKAQTQKFRDQLADGKTLDDILPEAFATVREASIRVLGMRHFDVQLVGGVVLHRGEIAEMKTGEGKTLVATLATYLNAIEGKGVHVVTVNDYLARRDAEWMGQLYTWLGLSVGVIVPNIPEHARRDAYNADITYGTNNEFGFDYLRDNMKHDRASMVQRPFNFGIVDEVDSILIDEARTPLIISGPTEDKTDLYIAVDEVVKRVDPEWYEADEKTKNISWTEDGNEAVEVLLKEAGLLETDNLYDVENTQVVHHLDQALKANIMFKKDTDYIVKDDKVVIIDEFTGRMMDGRRWSNGLHQAVEAKEGVKIEPENQTMASITFQNYFRMYPKLSGMTGTAATEASEFWDIYKMNVVEIPTNVPVQRIDEEDEFYKNTLDKFAAIAKAIAEKSAIGQPVLVGTVSIEKSELLSQFLDKEGVKHAVLNARFHESEAHIVAQAGRLGAVTIATNMAGRGTDIQLGGNVEFRIEDELKDMEDGPEREAAIERIKAEVKAEREKVLEAGGLFVLGTERHESRRIDNQLRGRSGRQGDPGLSRFYLCLEDDLLRIFGPDTLFAKMMNSNLEDGEAIGSKWLSKAIETAQKKVEARNYDIRKQVVEYDDVMNDQRKVIYEQRAEIMDSEAVDDVVVDMRHDTINALVTTACPPGSYPEQWDIEGLKERVEEVLGLAPPFDQWMEEEQIEPEIFEERIRELADKAMEEKIAATDPAMWKRVEKGILLDRLDHHWKEHLATLDALRQVVFLRAYAQKQPINEYKQEAFGLFERLLETLREDVTSILIKSEFRIAPPVEQELPDLPDFLTGHIDPLTGLDDSNDGDGSAQRAELFGSLAGSPRAAASPGGASGVTDNPYAGQDISRNAPCPCGSGSKYKHCHGAAI
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: ECHD2_BOVIN
Sequence: MLRVLTSTLRFPRPWKPLETRGCSSNPGAAGREIQVCALAGPNQGIAEILMNRPSARNALGNVFVSQLLEALAQLREDRQVRVLIFRSGVKGVFCAGADLKEREQMSEAEVGLFVQRLRGLMTEIAAFPAPTIAAMDGFALGGGLELALACDLRVAASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGAQAQALGLVNHAVAQNEEGNAAYHRARALAQEILPQAPIAVRLSKVAIDRGIEVDIASGMAIEGICYAQNIPTRDRLEGMAAFREKRLPRFVGE
What are the official names of this protein?
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the enoyl-CoA hydratase/isomerase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RHAB_PECCP
Sequence: MAVKNIVAVDLGASSGRVMLATLHTATQHLTLKEIHRFSNTLVFQDNHHQWDLAALERDILTGLHQIDAMGIVPDSIGIDSWGVDYVLLDQDGQRVGLPYSYRDHRTDGVMATVTAELGREAIYQRTGIQFLPFNTLYQLKALCDAPSDDLHQVAHLLMIPDYFHYRLTGSLVCEYTNASTTQLLSLEKKTWDSELLDYLGVPRRWLSDPVQPGHAVGKWAAPSGRQISVTAVATHDTASAVVGAPLQSRDSAYLSSGTWSLMGIESDTPFNSPQALAANITNEGGVDGTYRVLKNIMGLWLLQRVCQERDIKDLGALIEAAAALPAFASLINPNDDRFINPPSMHQAIRDYCREHGQPVPHSDAELARCIFDSLALLYRQVVLELGELRHAPIRQLHIVGGGSQNAFLNQLCADVCQIPVLAGPVEASTLGNIGCQLMALGAVADLAAFRHMLTHNFPLHRYTPRAESDFAGHWRRFQALSQPETAPKGKKETTQ
What is the function of this protein?
Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose).  Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate.
What are the official names of this protein?
Rhamnulokinase, RhaB, ATP:L-rhamnulose phosphotransferase, L-rhamnulose 1-kinase, Rhamnulose kinase.
What is the protein family that this protein belongs to?
Belongs to the rhamnulokinase family.
Protein: RL23_CALBD
Sequence: MLPEEIIKRPIITEKSMSMIPQKKYTFEVDRRANKIEIKKAVEQLFGVEVEKVWTMNVKPKRKRVGRFEGRTKAWKKAIVKLTDRSKTIEFFDSLI
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: FMRF_PLATR
Sequence: FMRF
What is the function of this protein?
Myoactive; cardioexcitatory substance.  Pharmacological activities include augmentation, induction, and regularization of cardiac contraction.
What are the official names of this protein?
FMRFamide.
What is the protein family that this protein belongs to?
Belongs to the FARP (FMRFamide related peptide) family.
What are the subcellular locations of this protein?
Secreted.