PharMolix/UniProtQA huggingface dataset:
Protein: LIAS_DROPS
Sequence: MLTAFRPNSPTAIVVRAASTNAKKLEEIRERLAKGPNFQDFVQNPDNLKSVGENYDGKLRREKGEEQRLRLPPWLKTTIPMGKNYTKIKEQLRELKLSTVCEEARCPNIGECWGGGENGTQTATIMLMGDTCTRGCRFCSVKTARIPPPLDENEPVNTAKAIASWGLDYIVLTSVDRDDLPDGGSKHIAQTVREIKARNSNIFVECLVPDFRGDLDCVETIANCGLDVYAHNIETVEKLTPYVRDRRAHYRQTLRVLTEAKRFNPNLITKSSIMLGLGETDEEIERTMTDLREAGVECLTLGQYMQPTNKHLKVIEYVTPEKFKHWEERGNDLGFLYTASGPLVRSSYKAGEFFISSILANRKANQSKDSAPKN
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, mitochondrial, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SCXN2_MESEU
Sequence: MNYLVMISLALLLMTGVESARDAYIANDRNCVYTCALNPYCDSECKKNGADSGYCQWFGRFGNACWCKNLPDKVPIRIPGECRGR
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  This toxin inhibits inactivation of Nav1. 4/SCN4A (EC(50)=2. 23 uM) and drosophila DmNav1 (EC(50)=220 nM) (PubMed:21969612, Ref. 2).  The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612).  In addition, the toxin accelerates the recovery from fast inactivation in Nav1. 4/SCN4A and DmNav1 (PubMed:21969612).  It also shows antimicrobial activity (Ref. 2).
What are the official names of this protein?
Sodium channel neurotoxin MeuNaTxalpha-2.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LIPA_SHEHH
Sequence: MNRPERLQPGVKLRDAEKVSRIPVKVVPSERETMLRKPDWLRVKLPASNQRITDIKQALRKNGLHSVCEEASCPNLSECFNHGTATFMILGAICTRRCPFCDVAHGRPLKPDAEEPKKLAQTIKDMKLKYVVITSVDRDDLRDGGAQHFADCIREIRLLNPEIKIETLVPDFRGRIDAALDILATEPPDVFNHNLETAPMHYRKARPGANYQWSLDLLKKFKERHPDIPTKSGLMMGLGESNEEIAQVLYDLRAHNVEMLTLGQYLQPSKFHLAVERYVSPAEFDELKELAESIGFTHAACGPLVRSSYHADLQAQGKEVR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TKN4_PSEGU
Sequence: QPNPDEFFGLM
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
What are the official names of this protein?
Substance P-like peptide 1, PG-SPI.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL19_ACIBY
Sequence: MSGKHPLVQAIENSQLKTDLPEFAPGDTVVVQVKVKEGDRERLQAFEGVVIAKKNRGLNSAFTVRKISSGVGVERVFQTHSPVVAKIEVKRRGDVRRAKLYYLRDLSGKAARIREKLPARKA
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: PYRF_DEIRA
Sequence: MTPTFAQAVTERTLSRRTRLCVGLDPRLGEYRDVAQLRQNTLDVLEASAPYAACVKPQLAFFEALGLPGFTLLEEVCAAARTLGLPVLLDGKRGDIGTTAAAYAQGWLGGTHAGDALTVNPFLGFQTLTPFVQAARENGGAIFVLVKTSNPDQQDLQGQGVSERIAVEIARLGDEEGLGDGDYASVGAVVGATHPGDLATFRALMPKALLLLPGLGAQGAQARDLAGAFHAGGTGALASASRAVQYARGLDVGAAREAALALRDELNGALGV
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family. Type 2 subfamily.
Protein: DNLJ_LACH4
Sequence: MAKITLDEAKKEAASLRTKLDEWADAYYSKDAPEVEDNVYDQSYNRLLELEKAFPEIVTPDSITQRVGGEIDSDFTKVNHPIPMLSMGDVFSKDELKEFDQRMQKLVGHPVEYNVELKIDGLSLSLEYQDGKLVRASTRGNGYIGEDVTANARYIADIPQVLPEPLTIEVRGECYMGKEAFAKLNQEREDEGLSVFANPRNAAAGSLRQLDPKVTKKRQLSTFIYTWVNPPREITSQHQAIERMHELGFHTNETGRKLANLDEVFDFIDEYTAKRNSLTYGIDGIVLKVDDLSLEQQLGNTVKVPRWEIAYKFPPEEQETIVRDIVWTVGRTGVVTPTAVMDPVQLAGTTVARASLHNPDYLNEKGVRIGDTVKLHKAGDIIPEISEVVLSKRPADSVPYEIPTTCPSCGQKLVHLEDEVALRCINPSCPAQVEEGIIHFASRPAMNIAGLGPKIVKQLIAKDLVHNVADLYHLTEDDLAQLDHFKEKSINNLLTAIDNSKKNSVELLITGLGIDHVGAKAARLIAQKFKNLEKIMSLGVQDIASIDTIGMTTAESMTTYFAQPEAQKLIEELRESGLNMDYLGADEPEEAPDNPFKDKTVVLTGKLEHYTRSEFTKKLQALGAKVTGSVSHKTDYVIYGKDAGSKYNKAEQLGVPLLTEEEAIAQIE
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: ATPF_DESVH
Sequence: MTLFFASMAYASGDSGHGPDWGNFAFRVVNFVIFAGIIWKAAGKKIVGFFTGRRQGIEQELNDLETRKTEAKKQLAEVERRIANLESERQAILADYRAQGENIKAAIIDKAEKSASLITEQAKRTADNEIKAAIDAMRAQMADEIIVAAEKLLAEKLTANEHEKLIDKYLTKVVLN
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: HEM1_BACC1
Sequence: MHILVVSVNYRTAPVEFREKLTFQATELEQAMTTLQKQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLEIEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEIMAEKYMGHAKPLSELQCALLEADILISSTGASDYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEKIQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETMESLERKIPTLSDRERKVISKHTKSIINQLLKDPILVAKEIAAEEGADEKLALFAKIFDLEMEDVESRAEEVEHKRAWTPSVPSL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: S2548_DANRE
Sequence: MTVFQLDDFLAGWIGGASSVIVGHPLDTVKTRLQAGKGYKNTFHCVVTIYKKENVIGFFKGLSFPLASITLYNSMVFGFFSNTQRLISKYRYGDGRHPCSMLDLTVASMLTGLVSVGVGAPVDLVKIRLQMQTQPVLAENFNLAGNGSVPLRSMGIQSQSFYRGPLHCISTVLQNEGIQGLYRGAGAMILRDIPGYALYFIPYTLFCNWLNPDDNSSPPPCCIWLAGGLAGSISWVTATPSDVVKSRLQADAMHQRKYKGILHCIMQSYRTEGIHVFFRGATVNAIRGFPMCATMFLGYELSLQFFRSF
What are the official names of this protein?
Solute carrier family 25 member 48.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL15_STRP3
Sequence: MKLHELKAAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKARSGGGVRLGFEGGQTPLFRRIPKRGFTNINTKEYALVNLDQLNVFDDGTEVTPAILKDAGIVRAEKSGVKVLGNGELTKKLTVKAAKFSKSAEAAIIAKGGSIEVI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: YVFD_VACCC
Sequence: MNHWQHPFIVQKAPIYKRKSRFDRDKLLTILSLFLTPPQFLISLVMKLFTISVSSLSTRDFTNLITLAVSFNRVVIFVCVILISF
What are the official names of this protein?
Uncharacterized 9.9 kDa protein.
Protein: PNCB_SALDC
Sequence: MTQFASPVLHSLLDTDAYKLHMQQAVFHHYYDVQVAAEFRCRGDDLLGIYADAIREQVDAMQHLRLQEDEFQWLSGLPFFKPDYLNWLREFRYNPAQVCVTNDNGKLNIRLTGPWREVIMWEVPLLAVISELVHHYRSPNAGVDQALDALESKLVDFTALTANLDMSRFHLMDFGTRRRFSREVQQAIVKRLQQESWFVGTSNYDLARRLALTPMGTQAHEWFQAHQQISPDLATSQRAALAAWLNEYPDQLGIALTDCITMDAFLRDFGIEFASRYQGLRHDSGDPVAWGEKAIAHYEKLGIDPLTKTLVFSDNLDLPKAVELYRHFASRVQLSFGIGTRLTCDIPQVKPLNIVIKLVECNGKPVAKLSDSPGKTICHDKAFVRALRKAFDLPQVRKAS
What is the function of this protein?
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
What are the official names of this protein?
Nicotinate phosphoribosyltransferase, NAPRTase.
What is the protein family that this protein belongs to?
Belongs to the NAPRTase family.
Protein: SYP_BORGP
Sequence: MSDFIASKEDDYSKWYLDIVQKAKLADYSPVKGCMVIMPYGYSIWSKIQSILDKKFKETGHENAYFPMLIPYGFLEKEKDHIEGFSPEFAIIKDAGGESLAEPLVLRPTSETIIWNMYSKWIKSYRDLPLKINQWANVVRWEKRTRPFLRTTEFLWQEGHTAHATEEEAVEETLLILDLYKRFMEDYLAIPVFCGKKSEKEKFAGAVSTYSIEALMQDKKALQAATSHYLGLNFAKAFDVKFQDKDGKMRHVFASSWGISTRLIGALIMVHSDEKGLILPPRIAPIEIIVIPIFKKEDEINKKILDYSDCVVHALKKAEFRVEIDKDVRSSPGFRFSSAEFKGIPIRIEVGINDVLLNSVTIMRRDKDRKFKYQISLDSLASKVKVELDSMQKDLFKKALNFRTLNTKEIFRIGKDSYELFKAYMNDHSGFVLSCWCGGLDCENIIKNETKATIRCIPDDFKAKDLTGMACIYCASRAKYFVLFAKSY
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CM3CD_CONRE
Sequence: KCCMRPICTCPCCIG
What are the official names of this protein?
Conotoxin Reg12d, Reg12k.
What is the protein family that this protein belongs to?
Belongs to the conotoxin M superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: LIGO1_MOUSE
Sequence: MLAGGMRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI
What is the function of this protein?
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors.  Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity).  Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
What are the official names of this protein?
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A.
Protein: KTHY_BUCAI
Sequence: MIKSKFIVIEGLEGAGKTNACICIKNLLKKNSIKNVLLVRQPGSTPIAEDIRRLIKKKFNDDNLIKETELLLMYAARIQLVEKKIKPALKNGIWVISDRHDLSSLAYQGGGLGIPKKIIYQLQSLFLNNFIPDLTIYLDVSPEIGLARALKRNPLDLIESRSLFFFKKTRRCYLEKSKLDKKTIIINANLNIKKVTQNITKKMLNWLNKQVI
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: Y048_MYCTO
Sequence: MAKWLGAPLARGVSTATRAKDSDRQDACRILDDALRDGELSMEEHRERVSAATKAVTLGDLQRLVADLQVESAPAQMPALKSRAKRTELGLLAAAFVASVLLGVGIGWGVYGNTRSPLDFTSDPGAKPDGIAPVVLTPPRQLHSLGGLTGLLEQTRKRFGDTMGYRLVIYPEYASLDRVDPADDRRVLAYTYRGGWGDATSSAKSIADVSVVDLSKFDAKTAVGIMRGAPETLGLKQSDVKSMYLIVDPAKDPTTPAALSLSLYVSSDYGGGYLVFAGDGTIKHVSYPS
What are the official names of this protein?
Uncharacterized protein MT0054.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FIBB_PAPHA
Sequence: NQEGLFHGR
What is the function of this protein?
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.  Fibrin has a major function in hemostasis as one of the primary components of blood clots.  In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization.  Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood.  However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo.  Enhances expression of SELP in activated platelets.  Maternal fibrinogen is essential for successful pregnancy.  Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage.  May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
What are the official names of this protein?
Fibrinogen beta chain.
What are the subcellular locations of this protein?
Secreted.
Protein: COBT_LEPBL
Sequence: MNPNELIVKLQSKIDLKTKPPGSLGTLESLALQIGLIQNTDSPELKSPHILVFAGDHGLANSGVSAYPKEVTYQMVFNFLNGGAAINAFCKQNSIRLKVVDAGVDFSFSDDSTFLHPDFIDAKVGFGTKNILIESAMTKEECNQALEKGAFISTKKVSSNCNVIGFGEMGIGNTSSASLITASVLKKDLREVTGKGTGLNDQKFQKKITILEECLCKHQSSLRTPFEVLQTFGGFEIAMMIGAMIDSAKKGRIILVDGFIATSAFLIAHKMEPTILKNAVFCHKSVEPGHIHLLEEWNAKPLLDLGLRLGEGAGCAIAFPILLSAIAFLNDMASFESAKVDQKL
What is the function of this protein?
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
What are the official names of this protein?
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, NN:DBI PRT, N(1)-alpha-phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CobT family.
Protein: PVCB_ERWAC
Sequence: MNPADLPDTLDVAPLTGETGEPCSFGILIKPCRAGRHIGELSVTWLRALVYSHQLVVLRGFDHFASSDSLTRYCATFGEIMMWPYGAVLELVEHANPDDHIFANSYVPLHWDGMYLDTVPEFQLFQCVHAAGDMQGGRTTFSSTNAALRIATPAVRELWARAHGRYQRSVELYSNTVEAPIIGIHPLREFPVIRFCEPPDENDATFLNPSSYSFGGINKDEEEMLLVSLMKTLRDPRVYYAHQWQTGDFVLSDNLSLLHGREQYTHHSGRHLRRVHIHGRPQIANHHLVRSE
What is the function of this protein?
Catalyzes the 2-oxoglutarate-dependent oxidation of tyrosine isonitrile.
What are the official names of this protein?
Tyrosine isonitrile desaturase, EaPvcB.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
Protein: THIE_BACAA
Sequence: MSRISKAEMSKLLSVYFIMGSNNCTKDPLQVLREALEGFITIFQFREKGEGALTGEERICFAKELQAICKEYGVPFIVNDDVELALELDADGVHVGQDDEGITSVREKMGDKIVGVSTHTIEEARWVIENGADYLGVGPIFPTSTKKDTKAVQGTKGLAHFREQGITIPIVGIGGISIENTASVIEAGADGVSVISAISLAESAYESTKKLVEEVSRSL
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: GSTT4_MUSDO
Sequence: MDFYYLPLSAPCRSVLMTAKALGIELNKKLLKLFEGGHLKPEFLKINPQHTIPTLVDNGFALWESRAIMVYLVEKYGKQDDPLYPSCPKKRALINQRLYFDMGTLYQGFANYFYPQFKEKKPADPELFKKFEVTLDFLNTFLSESKYAAGDSLTLADLALLASVSTFEAVNIDVSKYEHIARWYALVKETAPGADENWAGALEMKTLIPK
What is the function of this protein?
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
What are the official names of this protein?
Glutathione S-transferase 4, GST class-theta.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Theta family.
Protein: SESN2_MOUSE
Sequence: MIVADSECHSEIKGYLPFTRGGVAGPETREEHREGQARRGSRGPSAFIPVEEILREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYLSSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMTEFLQTGGDPEWLLGLHRAPEKLRKLSEVNKLLAHRPWLITKEHIQALLKTGEHSWSLAELIQALVLLTHCHSLASFVFGCGILPEGDAEGSPASQAPSPPSEQGTPPSGDPLNNSGGFEAARDVEALMERMRQLQESLLRDEGASQEEMENRFELEKSESLLVTPSADILEPSPHPDILCFVEDPAFGYEDFTRRGTQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQVACSLTYNTIAMHSGVDTSMLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKIYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT
What is the function of this protein?
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex.  In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling.  Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:18692468, PubMed:25259925).  This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses.  May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615).  May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085).  May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468).  Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).  Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (By similarity).  However, this could not be confirmed (By similarity).
What are the official names of this protein?
Sestrin-2.
What is the protein family that this protein belongs to?
Belongs to the sestrin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACY1_PONAB
Sequence: MTSKGPEEEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEERARQLGLGCQKVEVAPGYVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCISIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVSSILAFREKEWQRLQSNPHLKEGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVTLEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMKLTLEPEIMPAATDNRYIRAVGIPALGFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSES
What is the function of this protein?
Catalyzes the hydrolysis of N-acetylated amino acids to acetate and free amino acids.
What are the official names of this protein?
Aminoacylase-1, ACY-1, N-acyl-L-amino-acid amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACADM_PIG
Sequence: MAAMFRRSCRVLRSLSHFGWRSQHTKAVPQCEPGSGFSFELTEQQKEFQATARKFAREEIIPVAAEYDRTGEYPVPLLKRAWELGLMNTHIPESFGGLGLGIIDSCLITEELAYGCTGVQTAIEANTLGQVPLIIGGNYQQQKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPASKAFTGFIVEADTPGVQIGRKEINMGQRCSDTRGIVFEDVRVPKENVLTGEGAGFKIAMGTFDKTRPPVAAGAVGLAQRALDEATKYALERKTFGKLLAEHQGISFLLADMAMKVELARLSYQRAAWEIDSGRRNTYYASIAKAYAADIANQLATDAVQVFGGNGFNTEYPVEKLMRDAKIYQIYEGTAQIQRIIIAREHIGRYKN
What is the function of this protein?
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3233192).  The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:3233192).  Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).  Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (By similarity).
What are the official names of this protein?
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial, MCAD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: PUR9_VIBPA
Sequence: MNNARPIRRALISVSDKTGIVEFAQALAERGVDILSTGGTARLLAEQGIAVTEVSDYTGFPEMMDGRVKTLHPKVHGGVLGRRGQDDDVMAKHGINPIDMVVVNLYPFAETVAKDGCTLADAVENIDIGGPTMVRSAAKNHKDVTIVVNASDYDRVIAEMDANDKSLTLETRFDLAIAAFEHTAAYDGMIANYFGTMVPSYGENKEGDEESKFPRTFNQQFEKKQDMRYGENSHQAAAFYVEANPQEASVSTARQIQGKALSYNNIADTDAALECVKEFNEPACVIVKHANPCGVALGKDILEAYNRAYQTDPTSAFGGIIAFNQELDAETASAIVERQFVEVIIAPSVSAEAIEVVAAKKNVRLLECGEWTTKTTGFDVKRVNGGLLVQDRDQGMVSLDDLKVVSKRQPTEEELKDALFCWKVAKYVKSNAIVYAKGDMTIGVGAGQMSRVYSAKIAGIKAADEGLEVAGSVMASDAFFPFRDGIDAAAEAGIKCVIQPGGSMRDDEVIAAADEHGMAMIFTGMRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: VNFK_AZOCH
Sequence: MSNCELTVLKPAEVKLVKREREGIINPMYDCQPAGAQYAGIGVKDCIPLVHGGQGCTMFVRLLFAQHFKENFDVASTSLHEESAVFGGAKRVEEGVLVLARRYPELRLIPIITTCSTEVIGDDIEGTINVCNRALAAEFPERKIYLAPVHTPSFKGSHVTGYAECVKSMFKTITEVHGKGQPSGKLNVFPGWVNPGDVVLLKRYFKEMGVDATVFMDTEDFDSPMLPNKSIETHGRTTVEDIADSANALATLALARYEGATTGEYLEKTFAVPNSLVNTPYGIKNTDDMLRKIAEITGKEIPESLVREPRIAWIALADLAHMFFANKKVAIFGHPDLVLGLAQFCLEVELEPVLLLIGDDQGSKYKKDPRLQELKDAAHFDMEIVHNADLWELEKRINDGLQLDLIMGHSKGRYVAIEANIPMVRVGFPTFDRAGLYRKPSIGYQGAMELGEMIANAMFAHMEYTRNKEWILNTW
What is the function of this protein?
This vanadium-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.
What are the official names of this protein?
Nitrogenase vanadium-iron protein beta chain, Dinitrogenase 2 subunit beta, Nitrogenase component I.
What is the protein family that this protein belongs to?
Belongs to the NifD/NifK/NifE/NifN family.
Protein: SYS_PELPB
Sequence: MLDINTIRQHPEEIISMLHNRQLASEEPKIEQLLNLDRERKGLVQRSDDLKALRNKVSKEIAEIKKSGIGSSGELILQMKSVSEEIAGMDTSLGHLEEEIETILLGLPNKLHPSVPVGRSADDNQIFKEPISFPYHLDFPLKNHLELGKSLRILDFERGAKVCGAGFPVYIGKGARLERALINFMLDCHTERHGYTEVFPPFFVNQESLRGTGQWPKFADQVYHMEEDDLYAIPTAEVPITNLHRGEMLDTKTLPISYAAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVKFTRPEESYEALETIRENAEAILTALKIPYRVLLLCSGDISANATKCYDIEVWSPAEQKYLEASSCSNFEDYQARRANIRFKSESNAKPEFVHTLNGSGLATSRLMVSLLEHYQTAEGSIMVPEVLRHYTRFDEITQAAE
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.