PharMolix/UniProtQA huggingface dataset:
Protein: MED7B_ARATH
Sequence: MATATYPPPPPYYRLYKDFSENTDSAPEPPPPIEGTYVCFGGNYTTEDVLPSLEEQGVPQLYPKDSNLDYKKELRSLNRELQLHILELADVLVDRPSQYAKRIGEISSIFKNLHHLLNSLRPHQARATLIHIMELQIQQRKQAVEDIKRRREEAQGLLKDAFVTLDGQ
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 7b.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y748_STAA3
Sequence: MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
What is the function of this protein?
Displays ATPase and GTPase activities.
What are the official names of this protein?
Nucleotide-binding protein SAUSA300_0748.
What is the protein family that this protein belongs to?
Belongs to the RapZ-like family.
Protein: ALG14_DEBHA
Sequence: MDFESQLCIKVVLLLLPFFIIGIRLLWVLPAVNSPAMGSEKEKGLSQIPSELRGSNIMIFLGSGGHTGEMMRILANVDLNNFNRTWVTSSGDSTSILKCKKYEDERLTSGQNKSDYLVLHRARTVGESIISSVFSTVRSLISTIKHLYELPQFPSILLLNGPGTSVPLAYIIFLLKFLGLCKTRIIYIESLARVKQLSVSGLLILPITDRFIVQWKQLAVKYKRAEYYGILI
What is the function of this protein?
Involved in protein N-glycosylation.  Essential for the second step of the dolichol-linked oligosaccharide pathway.  Anchors the catalytic subunit ALG13 to the ER (By similarity).
What are the official names of this protein?
UDP-N-acetylglucosamine transferase subunit ALG14, Asparagine-linked glycosylation protein 14.
What is the protein family that this protein belongs to?
Belongs to the ALG14 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein.
Protein: POL_ALV
Sequence: MEAVIKVISSACKTYCGKTSPSKKEIGAMLSLLQKEGLLMSPSDLYSPGSWDPITAALSQRAMVLGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGGGRVSPPGPESIEKPATERRVDKGEEVGETTVQRDAKMAPEETATPKTVGTSCYHCGTAIGCNCATASAPPPPYVGSGLYPSLAGVGEQQGQGGDTPRGAEQPRAEPGHAGQAPGPALTDWARVREELASTGPPVVAMPVVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITMAEVEALMSSPLLPHDVTNLMRVILGPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQGRGERTNLDRLKGLADGMVGNPQGQAALLRPGELVAITASALQAFREVARLAEPAGPWADITQGPSESFVDFANRLIKAVEGSDLPPTARAPVIIDCFRQKSQPDIQQLIRAAPSTLTTPGEIIKYVLDRQKTAPLTDQGIAAAMSSAIQPLVMAVVNRERDGQTGPGGRARGLCYTCGSPGHYQAQCPKKRKSGNSRERCQLCDGMGHNAKQCRRRDGNQGQRPGRGLSSGPWPVSEQPAVSLAMTMEHKDRPLVRVILTNTGSHPVKQRSVYITALLDSGADITIISEEDWPTDWPVVDTANPQIHGIGGGIPMRKSRDMIELGVINRDGSLERPLLLFPAVAMVRGSILGRDCLQGLGLRLTNLIGKATVLTVALHLAIPLKWKPDHTPVWIDQWPLPEGKLVALTQLVEKELQLGHIEPSLSCWNTPVFVIRKASGSYRLLHDLRAVNAKLVPFGAVQQGAPVLSALPRGWPLMVLDLKDCFFSIPLAEQDREAFAFTLPSVNNQAPARRFQWKVLPQGMTCSPTICQLVVGQVLEPLRLKHPSLRMLHYMDDLLLAASSHDGLEAAGEEVISTLERAGFTISPDKIQREPGVQYLGYKLGSTYVAPVGLVAEPRIATLWDVQKLVGSLQWLRPALGIPPRLMGPFYEQLRGSDPNEAREWNLDMKMAWREIVQLSTTAALERWDPALPLEGAVARCEQGAIGVLGQGLSTHPRPCLWLFSTQPTKAFTAWLEVLTLLITKLRASAVRTFGKEVDILLLPACFREDLPLPEGILLALKGFAGKIRSSDTPSIFDIARPLHVSLKVRVTDHPVPGPTVFTDASSSTHKGVVVWREGPRWEIKEIADSGASVQQLEARAVAMALLLWPTTPTNVVTDSAFVAKMLLKMGQEGVPSTAAAFILEDALSQRSAMAAVLHVRSHSEVPGFFTEGNDVADSQATFQAYPLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGVNPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVAAQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFERGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVKNRDTDKVIWVPSRKVKPDITQKDEVTKKDEASPLFAGISDWAPWKGEQEGLQEEVASNKQERPGEDTLAANES
What is the function of this protein?
Catalyzes viral DNA integration into the host chromosome, by performing a series of DNA cutting and joining reactions (By similarity).  This recombination event is an essential step in the viral replication cycle (By similarity).  Has a strong preference for using the 3'-OH at the viral DNA end as a nucleophile (By similarity).
What are the official names of this protein?
Gag-Pol polyprotein.
Protein: AR13B_DANRE
Sequence: MFNLMANCCNWLKRWREPARKVTLVMVGLDNAGKTATVRGIQGESPLDVAPTVGFSKVDLKQGKFEVTIFDLGGGKRIRGIWKNYYSESYGVVFVVDSSDVQRIQETRDTMAEVLRHPRIAGKPVLVLANKQDQDGAMAEADIIETLSLEKLVNENKCLCQIEPCSAVLGYGKKVDKSIKNGLNWLLNNIAKDYEAISERVQKDTAEQKAQEEQDKKERAERVRRIREERDRQEREEAEREGRTLKEEELDDVNMFNPFQPINNVLTENQDRLNREKEMQRQRENGQQGSVQEQIALQDEEEEEEDEESERQTPESTESGAVDQTKKKTRKLRLKRKHRVDPLRMEEAAPKSPTPPPLPVGWATPKVSRLPKLEPLGDTRHSDFYGKPLPPVAIRQRPNSDTHDVIS
What is the function of this protein?
Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure.  May act by maintaining the association between IFT subcomplexes A and B.  Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear.  Required to pattern the neural tube.  Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling.  Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex Required during embryogenesis for cilia formation in multiple organs such as the pronephric duct.
What are the official names of this protein?
ADP-ribosylation factor-like protein 13B, ADP-ribosylation factor-like protein 2-like 1, ARL2-like protein 1, Protein scorpion.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Arf family.
What are the subcellular locations of this protein?
Cell projection, cilium membrane; Lipid-anchor. Note=Associates to the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone.
Protein: IF1_NITEC
Sequence: MAKEETIQMQGEVIETLPNATFRIKLENGHIVLGHISGKMRMNYIRILPGDKVTVDLTPYDLTRARITFRTK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_RHIL3
Sequence: MAEAATPKIGSVGRVTQVIGAVVDVAFEGELPKILNALETSNNGNRLVLEVAQHLGENVVRTIAMDSSEGLVRGQEVADTGAPIMVPVGNETLGRIMNVIGEPVDEAGPLVTAHKRAIHQDAPSYVEQSTESQILVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESNVNKHGGGEGSKAALVYGQMNEPPGARARVALTGLTVAEHFRDQGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGQMQERITTTTTGSITSVQAIYVPADDLTDPAPATSFAHLDATTVLSRSIAEKGIYPAVDPLDSTSRMLDPMVVGEEHYEVARKVQSTLQRYKALQDIIAILGMDELSEDDKIAVARARKIERFLSQPFFVAEVFTGSPGKLVALEDTIKGFKGLVNGEYDHLPEAAFYMVGSMEEAVEKAKKLAAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: APT_LACP7
Sequence: MKKLEEYVRSIPDFPEEGIIFRDVTSVLQDKDSLKMSIDQMQENLNGLDFDVIVGPESRGFIFGVPIAYNLNKAFIPVRKKGKLPCETVEMEYALEYGTATIEMHKDSIKPGQKVVIIDDLIATGGTIEAITKLIEQLGGEVVKIVFLMELEGLMGREKLKGYDIASVIKYAGK
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TIG_XYLFT
Sequence: MPVLIESIGNLERRLTFSVPEDRLESHVDERLREIARAARINGFRAGKVPAKVIEQRFGEKVRAEVLDSLLRETLDSAIRAHSLRLAGAARIDHANEGGLNFVATFEVVPDFGEIDVSKLGVVRRTAKVTDVDIDQMIENLRLQRRTWRVAEHGAQVGYLVALETWSQAGDERLPIEGVEAGSTILGSGVMFEQIERGLEGLSKGDENVLDVTFPDDWRVMQLAGKAVQVHVKVIEVSEPVLLEVNEEFIKSFGVKSGKLEDFRADIRANLERELKGALVSHLRREIGEQLIAAYAHVEMPPRLVEKEARLMLAKQIEQIRLSGRDPTVIPDDAHIGFMDAACKRVLVGLLVGEIAGRNRLRLDPMRVTETLHLIASTYEEPEEVFQMYRNDPKLMEGVQSLVMEEQVIEWIADRAQKTEQVLSFQEAIQQ
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: HSV2_DEBHA
Sequence: MNTLSAISNNKQSKELQILNINFNQDQGCFAVGHEYGFLVYNTNPIDIRVKRNFNINGHGSGIAHITMLHRTNYLALVGGGKNPKFANNKLVIWDDLKRKNSLNLEFMSPVLNVLLSRIRIIVVLKNQVLVYGFSSPPKKFATYETIENEFGLADLSVNFTNSIGNNLSTSNSSISSLVSNQVSYDSNKYQTLAFPGRSIGQIQIVDVSPSGQEKNLVSIIKAHKSKIRCLALNRSGTLVASASETGTIIRVHSTHNTALLYEFRRGLDRAIVTSMKFSHDDSKLAVLSDKNTLHVYNVSPLNTSSGATSDLVTHNETYPVNRSHLLGSIAFPIPIPKYFKSTWSFCSVNTNKYHPSGSDNDTINDVGIIGWSGNDSIIIIWQNKKIWEKYVIVEKRNKYLGDINDGLNTSHQGSSNWELVRFNWKNLDNLD
What is the function of this protein?
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
What are the official names of this protein?
SVP1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Vesicular and vacuolar.
Protein: Y062_ABVP
Sequence: MVIGNSVDLLIDLINENFDGNDNAYKNLVRYILRLIDCSVTDIQDSVFMFKQQSDTDDSEDN
What are the official names of this protein?
Uncharacterized protein ORF62.
Protein: CLPP_STRT2
Sequence: MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPIEDNMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNNLEQILADNSGQPIEKVHVDAERDNWMSAQETLEYGFIDEIMTNNQLK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASTD_SHIB3
Sequence: MTLWINGDWITGQGASRVKRNPVSGEVLWQGNDADAAQVEQACRAARAAFPRWARLSLAERQVVVERFAGLLESNKAELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGRANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLLLKSGAQGDAFLARLVAVSQRLTPGNWDDEPQPFIGGLISEQAAQQVVTAWQQLEAMGGRTLLAPRLLQSETSLLTPGIIEMTGVAGVPDEEVFGPLLRVWRYDSFEEAILMANNTRFGLSCGLVSPEREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATLNPGLDFSDEVVR
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: HEMH_KLEP3
Sequence: MHQTKTGILLANLGTPDAPTPGAVKRYLRQFLSDKRVVDTSRLLWWPLLRGVILPIRSPRVAKLYQSVWMEEGSPLMVYSRRQQQALAARLPDTPVALGMSYGSPSLASAVDDLLAQGVGHIVVLPLYPQYSCSTVAAVWDELARILAKKRAIPGISFIRDYADHPDYIHALAASVRASFAVHGEPDLLLLSYHGIPQRYANQGDDYPQRCRDTTRELVSALGLPPERVMMTFQSRFGREPWLTPYTDETLKMLGEQGTKHIQVLCPGFAADCLETLEEIAVQNREVFLEAGGEQYEYIPALNADVAHIEMMVNLTAPYR
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_BACC0
Sequence: MKERTIQPVNNGLNGNITIPGDKSISHRAVMFGAIAEGTTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGKGLEGLQEPKAVLDVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAIEYTSPVASAQVKSAILLAGLRAEGVTAVTEPHISRDHTERMLEAFGVKVTREGKTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGAIIPNSKLVLENVGMNPTRTGIIDVLEKMGATFTVEPINEGASEPAANITIETSSLKGIEIGGDIIPRLIDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSYGDHRIGMMLAIAGCIAEGKTIIEDAEAVGVSYPTFFEELQKLAK
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_CLOPE
Sequence: MKVLRVNLDEKSYDIVIQKDLKDYFGEYIKTVFDGKKVAIITDDNLNDIYGEAIKKNIENEGFEVEVISVTPGEKSKSFSVLPGIYNKLLDFKLTRSDLIIALGGGVVGDLAGFVASTFLRGISFIQIPTSLLAQVDSSVGGKVAVDLERGKNLVGSFYHPELVLIDPNMLGTLPEKYFNDGLGEVIKYGCIKSKELFEKLEGFENKEDLKENIGEIIYECCNIKREVVENDEKDLGERMVLNFGHTLGHAIEQIYNYEIYSHGEAVAIGMNMISKIAEEKDLTKKGTAERIESLLKKYGLNTDVNIEDNGLAREAIKLDKKNLNGNLNVILLKDIGEGYIYNTTVEFFE
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEKP4_ARATH
Sequence: MGEEDTKVIVEPTANGTSSLQKTSDAISGKEVQENASGKEVQESKKEEDTGLEKMEIDDEGKQHEGESETGDKEVEVTEEEKKDVGEDKEQPEADKMDEDTDDKNLKADDGVSGVATEEDAVMKESVESADNKDAENPEGEQEKESKEEKLEGGKANGNEEGDTEEKLVGGDKGDDVDEAEKVENVDEDDKEEALKEKNEAELAEEEETNKGEEVKEANKEDDVEADTKVAEPEVEDKKTESKDENEDKEEEKEDEKEESMDDKEDEKEESNDDDKEDEKEESNDDKEDKKEDIKKSNKRGKGKTEKTRGKTKSDEEKKDIEPKTPFFSDRPVRERKSVERLVAVVDKDSSREFHVEKGKGTPLKDIPNVAYKVSRKKSDEVFKQLHTILFGGKRVKATQLKAHILRFSGYKWQGDEEKAKLKVKEKFEKINKEKLLEFCDLFDISVAKATTKKEDIVTKLVEFLEKPHATTDVLVNEKEKGVKRKRTPKKSSPAAGSSSSKRSAKSQKKTEEATRTNKKSVAHSDDESEEEKEDDEEEEKEQEVEEEEEENENGIPDKSEDEAPQLSESEENVESEEESEEETKKKKRGSRTSSDKKESAGKSRSKKTAVPTKSSPPKKATQKRSAGKRKKSDDDSDTSPKASSKRKKTEKPAKEQAAAPLKSVSKEKPVIGKRGGKGKDKNKEPSDEELKTAIIDILKGVDFNTATFTDILKRLDAKFNISLASKKSSIKRMIQDELTKLADEAEDEEGEEEDAEHEEEEEKEKAKGSGGGEEVKA
What is the function of this protein?
Chromatin-associated protein which contributes to the modulation of chromatin structure (such as super-helical structure of DNA) and function (By similarity).  Binds to chromatin of protein-coding genes throughout the genome to regulate nucleosome occupancy and chromatin accessibility, and to modulate the expression of target genes (By similarity).
What are the official names of this protein?
DEK domain-containing chromatin-associated protein 4, At-DEK4, AtDEK-4, Protein DEK 4.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Note=Associates with chromatin (By similarity). Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei (By similarity).
Protein: CYSG_PSEU2
Sequence: MEFLPLFHNLRGSRVLVVGGGEIALRKSRLIADAGAVLRVVAPEIEAQLSELVVQSGGEMILRGYSECDLDGCVLIIAATDDEPLNAQVSRDARLRCVPVNVVDAPALCTVIFPAIVDRSPLVIAVSSGGDAPVLARLIRAKLETWIPSSYGQLAGLAARFRNQVKGLFPNVQQRRAFWEEVFQGAIADRQLAGQGAEAERMLIAKIAGEPPPETGEVYLVGAGPGDPDLLTFRALRLMQQADVVLYDRLVAPTILDLCRRDAERVYVGKRRAEHAVPQEQINQQLVALAKQGKRVVRLKGGDPFIFGRGGEEIEELAAHGIPFQVVPGITAASGCAAYAGIPLTHRDHAQSVRFITGHLKNGTTDLPWSDLVAPAQTLVFYMGLIGLPVICEQLIRHGRSADTPAALVEQGTTVNQRVFTGTLANLPQLVAEHDVHAPTLVIIGEVVKLREKLAWFEGAQATL
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: PM2P1_HUMAN
Sequence: MVTMCGGHRPENFLHQVLTEFGEELAGEGKSEVGGGAPRSYLQVASAECWAAAPAVHVGEPVHAGGLHTERGADPVIGLYLVHRGGACQTPTVGNRQTPTLGIHARPRRRATTSLLTLLLAFGKNAVRCALIGPGSLTSRTRPLTEPLGEKERREVFFPPRPERVEHNVESSRWEPRRRGACGSRGGNFPSPRGGSGVASLERAESSSTEPAKAIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLPQVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHYGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHKEFQRNIKKKRACFPFAFCRDCQFPEASPAMLPVQPAELTPRSTPPHPCSLEDNVITVFSSVKNGPGSSR
What are the official names of this protein?
Putative postmeiotic segregation increased 2-like protein 1, PMS2-related protein 2, Postmeiotic segregation increased 2-like protein 13, Postmeiotic segregation increased 2-like protein 6, Postmeiotic segregation increased 2-like protein 8, Postmeiotic segregation increased protein 3, hPMS3, Postmeiotic segregation increased protein 8, Putative postmeiotic segregation increased 2 pseudogene 1.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: DUT_NEUCR
Sequence: MTADTQTPVTKVDQAPPLLIKKLSDKARLPTRGSAFAAGYDIYASKETTIPARGKGLVETDISMAVPAGTYGRIAPRSGLAAKNFIDVGAGVIDADYRGQVKVLLFNHSDVDFVVNEGDRVAQLVLERIYTPEVVEVEQLEESVRGAGGFGSTGVGSGVGEQMKN
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: VNFA_AZOVI
Sequence: MSSLPQYCECGLGECRTDVLPLLYEMSQIATESGDLSSIISILLRLMKRHMKVVRGMVTLYDRDSGSIVLHESFGLSPEEAGKGVYLLGEGIIGRVVETGQSIVVPCIRDEPAFLNRTGSRDRDSDDANLSFICVPILRGRQVMGTISAERLYDNAELLKLDVEVLSILATTTAQAVELYLVENVENVALEAENRRLRSALGERFKPANIIGNSKPMLEVYQLIERVVRTRTTVLILGESGVGKELVAGAIHYNSPAAKGPFVKFNCASLPESVIESELFGHEKGSFTGAIGLRKGRFEEAAGGTIFLDEVGEMSLTTQAKLLRVLQERSFERVGGNTTIHVDLRVIAATNRNLAEMVADGTFAEDLYYRLNVFPITIPPLRERGSDIITLADHFVSRFSREMGIEVNRISTPRLNMLQSYQWPGNVRELENVIERAMLLSEDGVIHGYHLPPSLQAPVVGDSEAPPDGLEARLGAIEYELIVEALKLHHGNMTEAATHLGLTARVLGLRMGKYNLNYKDYR
What is the function of this protein?
Required for the expression of the V-dependent nitrogen fixation system in Azotobacter vinelandii.  It is required for the regulation of nitrogenase 2 transcription.  Interacts with sigma-54.
What are the official names of this protein?
Nitrogen fixation protein VnfA.
Protein: TRPA_LACLA
Sequence: MKTLQMTLSNKKNNFIPYIMAGDHEKGLEGLKETIQLLEQAGSSAIEIGVPFSDPVADGPVIEQAGLRALARNVSLSSILETLKTIDTKVPLVIMTYFNPVYQFGIEKFVAALEKTPVKGLIIPDLPKEHEDYIKPFINDKDICLVPLVSLTTPLSRQKELVADAEGFIYAVAINGVTGKENAYSNQLDQHLKALSSLTDVPVLTGFGISTLSDVDRFNKVSSGVIVGSKIVRDLHEGKENEVIKFIENAINF
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: GATC_HYPNA
Sequence: MSVTRDDVRKVARLSRIAVPEERLDELAGELNGILGWIDQLNEVDVEGVEPMTSVVETKLPMRDDVVTDGNIQDQVLANAPRSEHGFFVVPKAVE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: LPH_RABIT
Sequence: MELFWSIVFTVLLSFSCRGSDWESDSNFISAAGPLTTDLLLSLQYPQGNQTSDFAAGGKDLYVCSQPLPAFLPEYFSSLRASEITHYKVFLSWAQLLPAGHSGDPDGNAVRCYRQLLEALRAAQLQPMVVLHHQHLPASSALRSAVFADLFAEYATFAFHAFGDLVGVWLTFSDLEAAIRELPQPESRASRLQLLTEAHRKAYEIYHQKYAAQGGKVSVVLQAEEISELLLESSTSALAKDSIDFLSLDLSYECQSEMSLPEKLSKLQTIEPKVKVFIFTLRLQDCPSSRKSPASLLFSFIEAINKDQVLTLGFDVNAFLNCSSTSKKSISCFLTDSLALQTDHERAARNSAPVSTYQRVWEMFAHQPRAERDAFLQDTFPQGFLWGVSTGAFNVEGGWAEGGRGPSVWDQFGHLKAAQGQATPEVASDSYYKWASDVALLRGLRAQVYKFSISWSRIFPMGRGSSPSPQGVAYYNKLIDSLLDSHIEPMATLFHWDLPQALQDEGGWQNESVVDAFVDYAAFCFSAFGNRVKLWVTFHEPWVMSYAGYGTGQHAPGISDPGIASFQVAHLVLKAHARTWHHYNSHHRPQQQGRVGIVLNSDWAEPLSPERPEDLAASERFLHFMLGWFAHPIFVDGDYPATMKAQIQQRNEQCPSPVAQLPEFTDTEKQLLKGSADFLGLSHYTSRLISKAPEDSCIPSYDTIGGFSQHTDPAWPQTSSPWIRVVPWGIRRLLQFVSLEYTKGKVPIYLAGNGMPIGESENLLSDSLRVDYFNQYINEVLKAIKEDSVDVRSYIARSLMDGFEGPAGYSQRFGLYHVNFNESSKPRTPRKSAFLLTSIIEKNGFLTKAVKQPLPPNSAHLPSKTRASALPSEVPSKAKVVWEKFSNQTKFERDLFYHGTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGNGVTDNSTGDIACDSYNQLDADLNVLRALKVKAYRFSLSWSRIFPTGTNSSINSHGVDYYNRLIDGLLASDIFPMVTLFHWDLPQALQDIGGWENPSLIDLFDSYADYCFQTFGDRVKFWITFNEPTYYSWWSYGSGTFPPNVNDPGWAPYRISHALIKAHARVYHTYDEKYRQSQNGVISLSLVAQWAEPKSPDVLRDVEAADRKMQFTLGWYAHPIFKTGDYPDAMKWKVGNRSELQHLATSRLPSFTEEEKSYIRGTADVFCLNTYSSKIVQHKTPALNPPSYEDDQELAEEEDTSWPTTAMNRAASFGMRRLLNWIKEEYGDIPIYITENGVGLTNPRLEDIDRIFYYKTYINEALKAYRLDGVNLRGYFAWSLMDNFEWLQGYTIKFGLYHVDFENVNRPRTARISASYYTELITNNGMPLPSEDEFVYGQFPEGFVWSTSTAAFQIEGAWRADGKGLGIWDTFTHTRLKIENDDIADVACDSYHKISEDVVALQNLAVTHYRFSISWSRILPDGTTNYINEAGLNYYVRLIDALLAANIKPQVTMYHFDLPQALQDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVVAYHGYGTGLYAPGIYFRPGTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAAKRYVQFMGGWFAHPIFKNGDYNEVMKTQIRERSLAAGLNESRLPEFTESEKRRINGTYDFFGFNHYTTVLAYNFNYPSIMSTVDADRGVASIVDRSWPGSGSYWLKMTPFGFRRILNWIKEEYNNPPIYVTENGVSHRGDSYLNDTTRIYYLRSYINEALKAVQQDKVDLRGYTVWTLMDNFEWYTGFSDKFGLHFVNYSDPSLPRIPRESAKFYASIVRCNGFPDPAEGPHPCLLQPEDTDPTMSPVSQEEVQFLGLSLGSTEAETALYVLFSLMLLGVCGLAFLSYALCKSSKQRKKLSQQELSPVSSF
What is the function of this protein?
Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (PubMed:1388157).  The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other (PubMed:1388157).
What are the official names of this protein?
Lactase/phlorizin hydrolase, Lactase/glycosylceramidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
What are the subcellular locations of this protein?
Apical cell membrane; Single-pass type I membrane protein. Note=Brush border.