PharMolix/UniProtQA huggingface dataset:
Protein: MPSG_MACPH
Sequence: MADLPAKQTALTFQDDGTLGISHDAPVAELKPDMIIVKTAAVSVNPVDTKMESGFAKAGSIGGCDFAGTVVAVGAAVRRPVKVGDRVTGAVMGSDPNDPSSGSFATYVSAPADITLTLPESVPWAVGTSLSTVWFTVGQALFHHLLPDLAVTPSSPYAGDKPITVLVYGGSTSVGTAAIQLLKLAGLRPVTTCSPRNFDLVKSYGAEEAYDYRSPTCAADIKAATKSNLKYALDCITTKDSIAICYAALGRAGGRYTALDPYWEATAATRKTVKANWTLGITMLGKDIAWPAPYGRPGSEDARAFGAKWAAELQALLESGKMRPHPLRAKEGASWEDVLAGLKEVKEGKVSGEKLVFVF
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of macrophasetins, 3-decalinoyltetramic acids (DTAs) which feature a tetramate (pyrrolidine-2,4-dione) unit connected to a decalin fragment and that have potent bioactivities (PubMed:36452919).  The PKS-NRPS mpsA together with its associated enoylreductase partner mpsG incorporate one unit of acetyl-CoA, seven units of malonyl-CoA, and one unit of L-alanine to assemble the linear tetramic acid intermediate corresponding to the backbone of macrophasetins (PubMed:36452919).  Without the Diels-Alderase mpsD, the mpsA/G product can undergo the non-enzymatic intramolecular Diels-Alder (IMDA) reaction to generate both macrophasetin A and macrophasetin B (PubMed:36452919).  Catalyzed by mpsD, the linear tetramic acid intermediate is thoroughly converted to macrophasetin A via the endo-IMDA reaction in a regioselective and stereoselective manner (PubMed:36452919).  Finally, the cytochrome P450 monooxygenase mpsF catalyzes the hydroxylation at C20 to yield the end product macrophasetin C (PubMed:36452919).
What are the official names of this protein?
Trans-enoyl reductase mpsG, Macrophasetins biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: CEL2A_RAT
Sequence: MIRTLLLSALVAGALSCGYPTYEVQHDVSRVVGGQEASPNSWPWQVSLQYLSSGKWHHTCGGSLVANNWVLTAAHCISNSRTYRVLLGRHSLSTSESGSLAVQVSKLVVHEKWNAQKLSNGNDIALVKLASPVALTSKIQTACLPPAGTILPNNYPCYVTGWGRLQTNGATPDVLQQGRLLVVDYATCSSASWWGSSVKTNMVCAGGDGVTSSCNGDSGGPLNCQASNGQWQVHGIVSFGSTLGCNYPRKPSVFTRVSNYIDWINSVIAKN
What is the function of this protein?
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism.  Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity.
What are the official names of this protein?
Chymotrypsin-like elastase family member 2A, Elastase-2, Elastase-2A.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Elastase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KGUA_STAAW
Sequence: MDNEKGLLIVLSGPSGVGKGTVRKRIFEDPSTSYKYSISMTTRQMREGEVDGVDYFFKTRDAFEALIKDDQFIEYAEYVGNYYGTPVQYVKDTMDEGHDVFLEIEVEGAKQVRKKFPDALFIFLAPPSLEHLRERLVGRGTESDEKIQSRINEARKEVEMMNLYDYVVVNDEVELAKNRIQCIVEAEHLKRERVEAKYRKMILEAKK
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYW_COREF
Sequence: MTSQDNDHTAQTPARVLSGIQPTADSYHLGNYLGAVKQWIDLQNSYDAFYFIPDLHAITVDQNPEELRARTVSGAAQLLALGIDPERSTLFVQSHIPAHAELSWVLTCLTGFGEASRMTQFKDKSTKQGAERTSAGLFTYPMLMAADILLYRPQLVPVGEDQRQHLELTRTLAERFNNRFGTVFEVPEGFIPEGASKIYDLQNPTAKMSKSGENPKGLINLLDDPKVSSKRIKSAVTDNDGVIAFDVANKPGVSNLLVIQSALTGESVDKLVAGYEGKGYGALKTDTADALEAFTTPLRAKYDEYMSDRAELERVLAIGAERAGEIATKVLAEVYDKIGFLAPRSR
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRIQK_PONAB
Sequence: MGRKDAATIKLPVDQYRKQIGKQDYKKTKPILRATKLKAEAKKTAIGIKEVGLVLAAILALLLAFYAFFYLRLTTDDDPDLDQDED
What is the function of this protein?
May play a role in cell growth and maintenance of cell morphology.
What are the official names of this protein?
Triple QxxK/R motif-containing protein, Triple repetitive-sequence of QXXK/R protein homolog.
What is the protein family that this protein belongs to?
Belongs to the TRIQK family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: SYDND_GEOUR
Sequence: MIDFLGGWKRTHYCGALTAGDIGKEVVLMGWAHRRRDHGGLIFVDLRDREGLAQVVFDPDNSPAAHKKAEAIRNEYVVAIRGKVIPRPDGTVNANLKTGEVEVLVSECKMLNRSKALPFTLDDYVDVAENLRLKHRYLDLRRPVLQENLILRSKVAQITRQYLTGNGFLELETPFLTKSTPEGARDFLVPSRINRGEFYALPQSPQLFKQILMVSGFDRYFQVVRCFRDEDLRADRQPEFTQIDCEMSFIDREDIITVMEGLIARIFTETKGATVNLPIPRMTYAESIRRFGVDNPDLRFGLELVELSDIVKNAGFKVFADVVAGGGIVKGLNAKGCGGMSRKEIDDLTEFAKIYGAKGLAYVKMTAEGWQSPIAKFFTAEEISAMDKAFDAKEGDLLLFVADKPKVVNDSLGKLRNHLAKSLGLLDKDTFNFVWITDFPLLEWDEEEKRWAAVHHPFTAPMDEDLEYVESDPGRCRAKAYDLVLNGNEIGGGSIRIHQEKIQSLMFKMLGHSEEDARTKFGFLLDAMDYGAPPHGGIAFGLDRLIMLLTGSDSIRDVIAFPKTQKGACLMSEAPSAVDMKQLRELGLKTVVK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAGI2_RAT
Sequence: MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVTNMEKASIEPPEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQPEELKDQMDDTKSTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPAEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPADGQLDGTYPPPVHDDNVSVASSGATQAELMTLTIVKGAKGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGGFFSPWKTPKPMVDRWENQGSPQTSLSAPAVPQSLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYANSNHAAPSNNASPPEGFASHSLQTSDVIIHRKENEGFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNNPTSAPSSEKQSPMAQQHSPLAQQHSPLAQPSPATPNSPVAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQPSPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNPTPGALPLPPPQACRK
What is the function of this protein?
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (PubMed:9694864).  Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (PubMed:17724123).  May play a role in regulating activin-mediated signaling in neuronal cells (By similarity).  Enhances the ability of PTEN to suppress AKT1 activation (By similarity).  Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity).
What are the official names of this protein?
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, Atrophin-1-interacting protein 1, AIP-1, Membrane-associated guanylate kinase inverted 2, MAGI-2, Synaptic-scaffolding molecule, S-SCAM.
What is the protein family that this protein belongs to?
Belongs to the MAGUK family.
What are the subcellular locations of this protein?
Cytoplasm. Late endosome. Synapse, synaptosome. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Note=Membrane-associated in synaptosomes. Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation.
Protein: RL24_CLAMS
Sequence: MANIKKGDLVQVITGRTQAKGGDRGKQGRVLSVLVERNRVVVEGVNFVTKHVRVGQTQRGSKTGGIETVEAPIHISNVALVDPESKKPTRVGFRTETVEKDGVSKTVRVRYAKKSGKDL
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: NUOD_MAGSA
Sequence: MAESQIQSYTINFGPQHPAAHGVLRLILEMSGEVVDRADPHVGLLHRGTEKLIEHKTYLQATPYFDRLDYVGTMNQEHAFVLATEKLLGIDIPIRAKFIRTLYDEIGRILNHLLNVTAFIFDVGGMTPLLYGFEEREKLMEFYERVCGARLHANYYRPGGVAADLPAGLLEDIAAWCETFPKVLDDIETLATDNRIFKQRVVDIGVVSPEQALDWGFTGPNLRASGIAWDLRKSQPYDVYDQMEFDIPVGKNGDGYDRYLVRVLEMRESVKIMKQCIAKMPGGPVRVEDNKITPPKRSEMKTSMESLIHHFKLFTEGFKVPAGEVYGAIEAPKGEFAVYLVSDGTGKPYRCKIRPPGYVHLQALDMMSKGHMLADVVANIGSIDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HSPC1_RICFE
Sequence: MLKSAKLYIPSIAAIILSSNIAMAXNNYDTGHATPLRQVADLIDNQITNIDNLFKNRLPLYESNSIKSNFITKDKQYIIIMEVPGFDKSQIKIKVNGNKLFITRNIEEKNKADDSDNYMNKNFNYVISLYEDVDQANISSSLKNGILTIILPRIEIKEQDAREITIN
What are the official names of this protein?
Small heat shock protein C1.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: GUAA_SALPA
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVPAEERFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: SCN8A_RAT
Sequence: MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGVGSPRSSSELSKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGPGSHIGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQECKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKVKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGVDIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIDIVNNKTDCEKLMEGNSTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICRKMASNKLENGGTHRDKKESTPSTASLPSYDSVTKPDKEKQQRAEEGRRERAKRQKEVRESKC
What is the function of this protein?
Mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
What are the official names of this protein?
Sodium channel protein type 8 subunit alpha, Peripheral nerve protein type 4, PN4, Sodium channel 6, NaCh6, Sodium channel protein type VIII subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.6.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Note=Mainly localizes to the axon initial segment.
Protein: MNMG_THEVB
Sequence: MSTLPAFQDEFDVIVVGAGHAGCEAALATARLGCRTLLLTLNLDKIAWQPCNPAVGGPAKSQLVHEVDALGGEIGRVSDRTYVQKRLLNASRGPAVWALRAQTDKREYSAVMKQVVENQPNLLVREGMVTDLVLDANDTVIGVETYFGVAFRCQAVILTTGTFLGGRIWVGNKSMPAGRAGEFAAEGLSQTLARLGFEVDRLKTGTPARVDRRSVDYSKMEPQPPDEQVRWFSFDPTVWVERPQMNCYLTRTTPETHRLIREHLHLTPVYGGWVDAKGPRYCPSIEDKIVRFADKESHQIFIEPEGRNTPELYIQGFSTGLPEPLQLQLLRTLPGLENCIMLRPAYAVEYDYLPATQCFPTLMTKKIQGLFCAGQINGTTGYEEAAAQGIVAGINAARFVQRKPMITFPRQESYIGTLIDDLCTKELREPYRMLTSRSEYRLVLRSDNADQRLTPLGYEIGLVSEAQWQVFQAKQRRLAAETQRLQTTRIKAHEPVGEAIVTATGQAIKSAIALEELLRRSGVHYELLDRHGLGNPDLTPQEKEAVEIAIKYAGYIERQQREIEQIARQEQRPLPVDLDYFAIPTLSMEAREKLSAIRPLTIGQASRIGGVNPADINALLVYLQVQQQRQSLTAVGG
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GOG8Q_HUMAN
Sequence: MAEETQHNKLAAAKKKLKEYWQKNRPRVPAGVNRNRKTNGSIPETATSGGCQPPGDSATGFHREGPTSSATLKDLESPCQERAVVLDSTSVKISRLKNTIKSLKQQKKQVEHQLEEEKKANNERQKAERELEVQIQTLIIQKEELNTDLYHMERSLRYFEEESKDLAVRLQHSLQCKGELERALSAVIATEKKKANQLSSCSKAHTEWELEQSLQDQALLKAQLTQLKESFQQLQLERDECAEHIEGERARWHQRMSKMLQEICTLKKEKQQDMRRVEELERSLSKLKNQMAEPLPPEPPAVPSEVELQHLRKELERVAGELQSQVKNNQHISLLNRRQEERIREQEERLRKQEERLQEQHEKLRQLAKPQSVFEELNNENKSTLQLEQQVKELQEKLGEEHLEAASQQNQQLTAQLNLMALPGEGHGGEHLDSEGEEAPQPMPSVPEDLESREAMSSFMDHLKEKADLSELVKKQELRFIQYWQERCHQKIHHLLSEPGGRAKDAALGGGHHQAGAQGGDEGEAAGAAADGIAAYSNYNNGHRKFLAAAHNSADEPGPGAPAPQELGAADKHGDLREVTLTSSAQGEAREDPLLDKPTAQPIVQDHQEHPGLGSNCCVPLFCWAWLPRRRR
What are the official names of this protein?
Golgin subfamily A member 8Q.
What is the protein family that this protein belongs to?
Belongs to the GOLGA8 family.
Protein: RS10_BUCA5
Sequence: MQNQRIRIRLKAFDHRLIDQSTTEIVETAKRTGAQVRGPIPLPTRKERFTILVSPHVNKDARDQYEIRTHKRLIDIVEPTEKTVDALMRLDLAAGVDVQISLG
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: MURG_SOLUE
Sequence: MTHQQTLPTTAASFLMAGGGTGGHVIPALAVARELRSRGHKVFFVGTQHGMEARLVPPEGFEFKTIEIGGLNQVSWNQKFATLSRLPITTLKCGRSVRDASAVFSMGGYVAGPPVMAALVRRVPVVVMEPNAFPGFTNRVIARLVSRALVSFPETAAFFPKGRTEVTGLPVREEFFRIPPKARGDVLQILITGGSQGSRTLNHAARQSWPLFRNSGYPVRITHQTGTGSFQEIRDAFAQSGLEGEVVPFIADMPAAFAAADLIVCRSGAGTVSELAAAGKPSILVPFPFAADDHQTRNAQSLERAGAARLVRDAEMTGEKFFEVVTSVTGELSRMGTAARQFAKPGAAKRAADILEEVARP
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LEU1A_SOLPN
Sequence: MFFFLQLLVPIISVFQSKKHYYSTFIRCSISNRRPEYVPSKISDPKYVRIFDTTLRDGEQSPGATMTTKEKLDVARQLAKLGVDIIEAGFPASSEADFESVKLIAEEIGNNTDENGFVPVICGLSRCNKSDIDKAWEAVKYAKKPRVHTFIATSEIHMKYKLKMSREQVVEKARSMVAYARSLGCEDVEFSPEDAGRSDREFLYDILGEVIKAGATTLNIPDTVGYTVPSEFGQLITDIKANTPGIENVIISTHCQNDLGLSTANTLAGACAGARQLEVTINGIGERAGNASLEEVVMALKCRGEQVLGGLYTGINTQHIVPSSKMVEEYSGLQVQPHKAIVGANAFAHESGIHQDGMLKHKDTYEIISPDDVGLSRSNEAGIVLGKLSGRHALKSKMLELGYDIDGKELEDLFWRFKSVAEKKKKITDDDLIALMSDEVLQPNVYWKLGDVQIMCGSLGLSTATVKLINTDGQEHIACSVGTGPVDAAYKAVDLIVKVPITLLEYSMNAVTEGIDAIASTRVSICSIDRHTIMNGSTGQTIHRTFSGTGADMDVVISSVRAYIGALNKMLSYEKLVSRYSKPEDSVVV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase A, Alpha-IPM synthase A, Alpha-isopropylmalate synthase A.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: LYRIC_RAT
Sequence: MAARSWQDELAQQAEEGSARLRELLSVGLGFLRTELGLDLGLEPKRYPSWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEVTPPTPAPEDPAQLKNLRSEEQKKKNRKKLPEKPKPNGRTVEIPEDEVVRTPRSITAKQPPETDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENITVNGGGWSEKSVKLSSQLSAGEEKWNSVPPASAGKRKTEQSAWTQDPGDTNANGKDWGRNWSDRSIFSGIGSTAEPVSQSTTSDYQWDGSRNQPHIDDEWSGLNGLSSADPSSDWNAPAEEWGNWVDEDRASLLKSQEPISNDQKDSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSITQDTEDLEKDTREELPVNTSKARPKQEKACSLKTMSTSDPVEVLIKNSQPIKTLPPAISAEPSVTLSKGDSDKSSSQVPPMLQDTDKPKSNAKQNSVPPSQTKSETNWESPKQIKKKKKARRET
What is the function of this protein?
Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically.  Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor.  Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion.  Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium.  Induces chemoresistance (By similarity).
What are the official names of this protein?
Protein LYRIC, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Cell junction, tight junction. Nucleus, nucleolus. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain. TNF- alpha causes translocation from the cytoplasm to the nucleus (By similarity).
Protein: AROE_HISS2
Sequence: MDKYAVWGNPIAQSKSPQLHRYFAKQTRQNLDYVAILGDEEKFEQQLSDFFAQGAKGCNITAPFKERAFKLAQQHSKRCLSAESCNTLKKLADGTLFADNTDGAGLVSDLQRLNWLKPNQRILILGAGGATKGVLLPLLQAQQNILITNRTFSRAEDLAHKFNQFGTIEALDLKHIPIQTFDLIINATSTGLQGKTIDINPQILQLASAVYDMQYSKESDTPFIALCKKQGVTKISDGFGMLVGQAAHAFYLWRGVMPEIDPLFSGNEIKI
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: AHPD_MYCPA
Sequence: MSVENLKEALPEYAKDLKLNLGSITRTTELNEEQLWGTLLASAAATRNTQVLTEIGAEAADTLSAEAYHAALGAASVMAMNNVFYRGRGFLDGKYDDLRAGLRMNIIGNPGVEKANFELWCFAVSAINGCPDCVASHEHTLREAGVSRETIQEALKAAAIISGVAQAIVASQTLATAG
What is the function of this protein?
Antioxidant protein with alkyl hydroperoxidase activity.  Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
What are the official names of this protein?
Alkyl hydroperoxide reductase AhpD, Alkylhydroperoxidase AhpD.
What is the protein family that this protein belongs to?
Belongs to the AhpD family.
Protein: NRIF1_MOUSE
Sequence: MASTLPTTWPHESVKFEDVSLTFTEEEWAQLDFQQKCLYREIMMENYSNMISVEHHFSKPNVISQLEKAEDCWPMQREIPQDTLPECSWPSPDPGMNSFPSKSPLMKIEVVEVLTLNKDVAGPRNALIQSLYPEDLNPGNLKPAQQPSKRLTDTEASRQKFRHFQYEESAGPQKAMSQLRKLCHQWLQPNTRSKKQILELLVLEQFLNALPEKFRVWVESQHPEDCKAVVALLENMTSVSKDDASLACSSEATDQLKEKRKGVATLPVTFAAEVPAEEPVTFQDVAVDFNEEEWRLLGPTQKTEYHDVMLETLGNLVSVGWEPTLGNRELTPDSPIPVVKPIHDPNTNDLSRNGTQSTVFESILEDGVKEMHSIESNQVGNLQEKGHPQKKFSESSKSQDQTSRHKSQGSLNEVLPRKYVKVKQKGTGKRKGRTNTISMTRGLRIRKQQKDSVEWQGRSGSTPVTHGSSIKKQQQGSEQGKPGTSRDPITLTVPAKVYQKATGSEESIFMDSSDAMVPDVPPKIHQKGPEWHKVGESNNSMLQGSSVQNHQMESGAGRASDNSLLTHALPVKSHQKGYKEGNVQGNRNSWKHIKPHQKGSKGERVEELSTSEKHVPYVKNHLKTSERGKDREINASIKCDPYIKTYYRGSDVGRLRRANNCRKAFSLHAQQISFIKIHKGSQVCRCSECGKLFRNARYFSVHKKIHTGERPYMCMACGKAFVQSSSLTQHLRIHSGERPFECSECGRTFNDRSAISQHLRTHTGAKPYHCERCGKAFRQSSHLTRHERTHTGERPYVCIKCGKAFTQSSHLIGHQKTHGIKFKKQPKL
What is the function of this protein?
Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis.  Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis.  Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons.  May also regulate expression of neuronal cholesterol biosynthesis genes.  Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression.
What are the official names of this protein?
Neurotrophin receptor-interacting factor 1, Neurotrophin receptor-interacting factor, Zinc finger protein 110.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocates into the nucleus following binding to TRAF6 and subsequent ubiquitination at Lys-15.