PharMolix/UniProtQA huggingface dataset:
Protein: RNC_RHIME
Sequence: MKGRSLNTEDRARLEAAIGYRFAEKERLDRALTHSSARSGRAINYQRLEFLGDRVLGLCVAELLFQTFTDANEGELSVRLNQLVSAESCAKVADELSLHEFIRTGSDVKKITGKHMMNVRADVVESLIAAIYLDGGLDAARRFVLEHWTHRAASADGARRDAKTELQEWAHAKFGVAPKYRTDDRSGPDHDPRFTVTVEVDGIAPETGVDRSKRGAEQVAAMKLLEREGVWQKRSAGN
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMT1_WEDBI
Sequence: MAAVTGLYGSIDEFLNHCSQSGDSAYSALRSLLERLEKPDTRTEARIFLAHLQKKLDNDGASQRCLETYHFQIQDIYLDRNEGTGYQNRKKFTMMVIPSIFMPEDWSFTFYEGINRHPDSIFKDKTVAELGCGNGWISIAIAEKWLPLKVYGLDINPRAVKISWINLYLNAFDEDGQPVYDSESKTLLDRVEFYESDLLSYCRDNHIELERIVGCIPQILNPNPDAMSKLVTENASEEFLHSLSNYCALQGFVEDQFGLGLIARAVEEGIDVIKPMGIMIFNMGGRPGQGVCKRLFERRGLSVNKLWQTKILQASDTDISALVEIEKNNPHRFEFFMGLVGDRPICARTAWAFGKACGRISHALSVYSCQLRHPNEVKKIFEFLKNGFHDISNSLDLSFEDDSVADEKIPFLAYLAGVLKDGSRFPYEPPTGNKRFRDLIASFMKTYHHVPLSTDNVAIFPSRATAIENSLRLFTPRLAIVEEHLTCNLPRQWLTSLEIEQTRDSKTPIDGITVIEAPRQSDLMIELIKKLKPQVVVTGIAQFEAVTSSAFEHLLRVTREIGSRLFIDISDQFELSSLPSSIGVLKYLARTPLPSHAAIICGLLRNRVYTDLEVAFVISEEQTIFDALTRTVELLQGNTALISQYYYGCLFHELLSFQIPDRRQTAEREAENVEASDIDMIGFSSSAISVLSQSELSVRVTEKSSLLHMDVDQIFLPTPTPVKAAIFESFARQNVTETECDVTPILRQFILNTWNFSVEHSAEFIYADFPLALFNKLVLCCIEEGGSLCMPAGSNGNYAAAAKFLNANIMSIPTEAEVGFKLTAKQLSSVLETVHKPWVYISGPTINPTGLLYSNEEMKSLLTVCARYGARTIIDTSFSGIKFNSQDWDGWNLDASLAGLTGNPSFSVCLLGGLFFKIPTGGLSYGFLVLKSGFLADSFRSSFSGLNKPHNTVRYTAKKLLELGEQKGNLTGAAQGQEKLLATRLKRLKETLENCGWEVIEARGGVSVIAKPSAYLGKNIKLEKDGSTWVTKLDGTNIREAMLRATGLCINGPSWTGIPDYCRFTFALEDGDFDRALDCIVKFNQLVK
What is the function of this protein?
Catalyzes the S-methylmethionine (SMM) biosynthesis from adenosyl-L-homocysteine (AdoMet) and methionine.  SMM biosynthesis (by MMT1) and degradation (by HMT-1, HMT-2 and HMT-3) constitute the SMM cycle in plants, which is probably required to achieve short term control of AdoMet level.  Also able to catalyze the selenium-methylmethionine (SeMM) from AdoMet and selenium-methionine (SeMet).  May play a role in phoem sulfur transport; such function is however not essential.
What are the official names of this protein?
Methionine S-methyltransferase, AdoMet:Met S-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_RUEST
Sequence: MAAKPPLTLYLAAPRGFCAGVDRAIKIVEMALEKWGAPVYVRHEIVHNKFVVDGLRDKGAVFVEELEECPDDRPVIFSAHGVPKSVPAAAEARQMVYVDATCPLVSKVHIEAQRHAEAGLQMIMIGHKGHPETVGTMGQLPEGEVLLVETVEDVAQVEVRDPERLAFVTQTTLSVDDTKDIVAALQARFPAIVGPHKEDICYATTNRQEAVKEVAPKADALLVVGAPNSSNSRRLVEVGAKNGCSYAQLVQRAENIDWRALEGIQSIAITAGASAPELLVNEVIDAFRDRYEVTVELVETAVERVEFKVPRVLRTA
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: CTC1_ARATH
Sequence: MENTTILTVKDLVNEGIAVTGASSLFSSAASHSSSESTSTNPKSHPGAVDSDFSRKFLTPLNYPTVIFGTVALPSETLKCPNRYCFRFTDGDLTICCDILGFEFRAIGSKICVLSWNFLPMNHSGGFLEIINWKFVDSGSLLSRCSGISSFPLIPSLYSSQNGDRKSRYSVCGVLESISPVSVVPCMDGVSSDSVNLPGFLVHVMACECKVYSRDAIDCGHAFERSVFVYFCGLEAASWHPVVMKLVGRNVALSGLKRKLVYVRGDSLLVFVTTENSVLHPPWLSKKGTVSKTVVDRRGNCGSYRGYVRGLYLKGKLVEMDEDVWLLLTDQILNRSHSIRTGSLIFIRNVHFVNTKFPWGEVLILGACFKTSITVEFFSPFETSCLVDSCRQTSLSLYVESLSFPARLWTLLVRISFEKFNRMPSDKEILRSCQKDELTKMYAESRIPPSMFQPRGGIFTEFCMHESCGCNSEARDCNLKLVMPISSFVHHVKVMLNELLSQIKKDFSASDCLSHSSSTWKRYNNTNPKTLRSEDTGVILLGRLKISSSGRLQLHDRTSSIDVLTPDLLSDRNASRICEVPDYYLIIEGIPESMLHMPFLKNPFRCSSVLNPTPLAIKNTLTVPFSLSLGTASCKHLLKHHPFDWRHDFNEFKEGFFHLFRVTHKFPILKNGHPGMPDCTSVFIEALVLPWDLICTVTEEEAAAPNFEEHDTSQEIRPHKRCKTNNGLQSQSFLSVPHEISCQMTIRCASSHCLVATATLSNLTENKSGKMHSAMRVLLEFIPECSNYYGLQIGGCYLMKHGSDDSFCVGRSGISNNDKINFRPETRLWSLEFSFDEVLTHDGSMDVHPLVSSQPSFAVEQQNVSSRQPCSDVSLLLPYDAKGLFSVFLNDLEGLNKPLAAGKDNNNISCCTQSETIMHAEPSRLLPSNSLFPEGNLATFRGDVVAVDAVTSSVVDVSSSYCINVLVNHQMVKIFGPLRRHSYLTGFGFGTNATFYRILGTGEQNSFVLTSASFIKINSRKALDSPPLEKPTHGAALCLPKITPQEFVPCILAGPACNSFSGNEDNQQIKFACKVLSVYLLVLQTRSDDPSENECRNNIDIPLAGFVVDDGSSTYLCWTSGERAFTILRLHEELPEETIDVVQWTRRYSNWGTTAYHLDQIVRVHKRIVMKCNGSQIDVLFQDITIAVTSDQLLTKSEDKFLKWLILNAISGPIWEVAASSMDMKMIEHLEREQCVEMETSRYNLQSVWGNEVCQVDPLVRAWSLLQGLLNS
What is the function of this protein?
Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation.  The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves (PubMed:19854131).  Associates with enzymatically active telomerase (PubMed:25329641).
What are the official names of this protein?
CST complex subunit CTC1, Protein CONSERVED TELOMERE MAINTENANCE COMPONENT 1, AtCTC1.
What is the protein family that this protein belongs to?
Belongs to the CTC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: DXS_VIBA3
Sequence: MTLDISKYPTLALADKPEDLRLLPKETLTQLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYNTPFDQLVWDVGHQAYPHKILTGRRDRLSTIRQKDGLHPFPWREESEYDTLSVGHSSTSISAALGMAISAKKEGKNRKVVSVIGDGAITAGMAFEAMNHAGDIHNDMLVILNDNEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGVPPIKELVRRTEEHLKGMVVPGTMFEELGFNYIGPVDGHDVNELIKTLKNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGYHGVPKFDPAHSSLPKSTSSKPTFSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYPKQYFDVAIAEQHAVTLATGMAIAGDKPIVAIYSTFLQRGYDQLIHDVAIMDLPVMFAIDRAGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGHQHTGPSAVRYPRGNGMGTEIQSEFTALEIGKGRIVRESKKAKDGSKVAILSFGTFLESALQTADAIDATVADMRFVKPLDEALIKQLAADHDVLVTIEENAIAGGAGAGVIEFLMQEKLLMPVLNLGLPDKFIAQGTQDELHEELGLDAKGIEKSISDYLAK
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: TRXB_MYCLE
Sequence: MNTTPSAHETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALMTTTEVENYPGFRNGITGPELMDDMREQALRFGAELRTEDVESVSLRGPIKSVVTAEGQTYQARAVILAMGTSVRYLQIPGEQELLGRGVSACATCDGSFFRGQDIAVIGGGDSAMEEALFLTRFARSVTLVHRRDEFRASKIMLGRARNNDKIKFITNHTVVAVNGYTTVTGLRLRNTTTGEETTLVVTGVFVAIGHEPRSSLVSDVVDIDPDGYVLVKGRTTSTSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSKANETTEETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKPVLVDFWATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDTNPEMAREFQVVSIPTMILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN
What are the official names of this protein?
Bifunctional thioredoxin reductase/thioredoxin.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAMB1_YERPP
Sequence: MITLRKLPIALAVAAGVLSTQAMAVDFHGYARSGIGWTASGGEQQCFQTTGAQSKYRLGNECETYAELKLGQELWKEGDKSFYLDTNVAYSVSQRDDWESTDPAFREANVQGKNLIESLPGSTIWAGKRFYQRHDVHMIDFYYWDISGPGAGLETIDLGFGKLSVAATRNSESGGSSAWIDNQRENAKYTINNVYDVRLAGLETNPGGSLELGVDYGRADTQEGYSLAPNASKDGVMLTAEHTQSLMGGFNKFVVQYATDSMTSYNTGHSQGTSVNNNGHLLRVIDHGAINLAEKWDMMYVALYQDIDLDNNNGNTWYSVGVRPMYKWTPIMSTLLEAGYDNVKSQHTGERNGQYKLTLAQQWQAGDSIWSRPAIRVFATYANWDEKWGYSDTTGVAQDGTIGTNSRGKNNEVTFGAQFEAWW
What is the function of this protein?
Involved in the transport of maltose and maltodextrins.
What are the official names of this protein?
Maltoporin 1, Maltose-inducible porin 1.
What is the protein family that this protein belongs to?
Belongs to the porin LamB (TC 1.B.3) family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein.
Protein: PAX9_HUMAN
Sequence: MEPAFGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPSPITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPKVEEWSSLGRNNFPAAAPHAVNGLEKGALEQEAKYGQAPNGLPAVGSFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAGHGWQHAGGTSLSPHNCDIPASLAFKGMQAAREGSHSVTASAL
What is the function of this protein?
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
What are the official names of this protein?
Paired box protein Pax-9.
What are the subcellular locations of this protein?
Nucleus.
Protein: WDY_DROMO
Sequence: MSLIYFASGDSHANIEYQTISSTATEANQEQSERLHDRISKAQLQRLYERFKSAPDQVVGCADFRRMLEEVDIVFSDFTYTRLFLKINQNHDFLVDWNEFVSYLIFGFQEEDPSSQKESLIMPISAAPVVRKTEHRSAVCCITLLKVKSDQTPLEDMTESANYSFGGEDSPENSGMWVTASHEGQLRFWSAHMEPLRSAVSESIYCMSYAFYNNGKTHSKLVLGDYAGNVRILSYSPYLRGPFQAKPGAALVELTWADVLRGRIPLLIPKEYINLHNELISCVYYSLHMNALFASAEYRNTKKYRGRCPGLIMVSNDDRNNFRIPLGVSVFYVSEVKNILVTGGPDTFVRIWDVYISSEPSAILTGHNGGIVAVFVQPEENKVYSVDYHKIIKVWDLQEHTLLQTYGELVRIIHHSEMDIKYYYHSHLRELMVAGRKLIQVKCCPRVRVDLTDGNTHAAPVSVVLYNRLFRNIVTCGLDSYIIVWDPWTGRRKIIMKNCHTKMIYGETIDIEITAACFDPLEQFLLTGARDGSLKIWNYNNSVVVRNMSIQMDQEVTAVIWVVDRILAMGWDRQVTEFNDVEGREYGDPKKWAKFHTDDITCADVKLGEGVVTATYSGEIIFWKLETGQPYRRYNVMDPSQFIELKLTAEEEKLSRRSKRISSLLGANRRSASMLAIKPDEIKDYGANIPVSVQAVLFLQKRPMTKDHGSVFISLDTGIIQVYSHHQHGGHIKEFIAVHKVGDCVLTMATDRKNRFLYTGTAFGYIKIWHIVNYCIPEAEKTHVCMPKLRLDFIFLRKELFLTRAKRMVRNQPEPMLVSSYKGHLKAINSIGFINLPKILFSGSHDYSCRLWTQSGRYLGTLGTVLPWSKLSPFERAGEENRPYRLPPDIKKVASSTTLKVISGVQHSFQVKRPKPTEEREDEGEVEDTGTEMKNIFDRPLREPILGKHFELPGRSAIEQRIELDTTQLYVPIYSHLRVHPSDVMENLPTPPIIGQVKSENYLDHYMPVVGKVDPNTSAINIREPNKVIRSKAGGQVGQARASSTWGKPKTNSILGMPRAESSQGKARASSAKAGVSSGYGRTNFGPNPSRVRSNSPKVSFMPSQLKTCRKPESSPRKAKTSPARAKSVSFPAKANPVSTSAKANPTCTSVKTNPVPTSAKASRVSTSAKSNPVSTSANAKPDIMPVKIKPVVKKPSRNTAPVQITTSIAKTKKDKP
What are the official names of this protein?
WD repeat-containing protein on Y chromosome, WD40 Y.
Protein: MLTF_VIBC1
Sequence: MQISQFNRLKRSALLFASVLLLSACQIESEPKSEFEQIQERGVLRVGTLNNQLSYYIGPDGPAGLDYELARKFAEQLGVKLEIRPAFRQAELFPALKKGDIDIIATGLNQTSQAVQRFRPGPAYYYVSQQVVYKKGQLRPRDVDQLIKYQESKDEKAGNEDSNAGAETLQIVEQSQFVPTLTALQKEHPELQFEIIGDADTRDLLKHVSTGELRFTVTDSVELSLAQRLYPDLALAFELTEDQPVSWFTRRSEDESLYAMLIEFFGNIKQSGELATLEEKYIGHIEAFDYVDTRAFIRALDNTLPKWSPLFQKYSEEFDWRLIAALAYQESHWKPKAKSPTGVRGMMMLTLPTAKSVGVTDRLDPEQSVRGGVEYLRRIVARVPDSINEHEKIWFALASYNVGYGHMMDARRLTKAQGGDPNAWADVKERLPLLRQKRYYSQTRYGYARGDEARNYVENIRRYYQSIIGHVSQKPAIDEDTEDLQVIPPLDPNLLVSGAVETLAEQVSGAVEVTPPPEENAPQEAEQTPVPKAE
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: ACP_STAES
Sequence: MENFDKVKDIIVDRLGVDADKVTEDASFKDDLGADSLDIAELVMELEDEFGTEIPDEEAEKINTVGDAVKYINSLEK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_HELP2
Sequence: MQEIVIPLKEKSYKVFLGELPEIELKQKALIISDSIVAGLHLSYLLKRLKALEVRVCVIESGEKYKNFHSLERILNNAFEMQLNRHSLMIALGGGVISDMVGFASSIYFRGIDFINIPTTLLAQVDASVGGKTGINTPYGKNLIGSFHQPKAVYIDLAFLKTLEKREFQAGVAEIIKMAVCFDKNLVERLEMKDLKDCLEEVIFQSVNIKAQVVMQDEKEQNIRAGLNYGHTFGHAIEKETDYERFLHGEAIAIGMRMANDLALSLGMLTLKEYERIENLLEKFDLIFHYKIIDIQKFYERLFLDKKSENKTIKFILPKGIGAFEVASHIPKETILKVLEKWH
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LINES_DROME
Sequence: MDTSSAAGSGAGTGDVCPCSTVATSTTSASNEQPQTKRQKIEQQIKVGSKALPPQPPHPPDILDLDANSNSHLCSSLSSSSSHSLSTPSTANNSPTTTPCSSRAASYAQLLHNILPQNGDTDLHSQPESAHDEVDRAAKLPNLLTLDTTNGNGSHASSRSNCLQATTATSIDDMLEFEQSLTRQCLCGVSERTLRKPFQSHYSQDTNGQKRIAYLREWPTNKLLQFLSNLQLLFDIYLKQNAKGFICTRIMDVCDALIRNDHKLIDEIIVLAGYENSYVQFLAGRVLAAFLVIAKQELNDEWLQKIVDQLFNFEQLDQAAVQKIHFSLDIIKRIVEWKDMEIHPLDDDWMASANSTSAASSVVPLSTEASVSYMHFPVQEQPLATNYFALQFREDTEGERETGQEAPDNRDRHRRHFGEDMNVAYEPHPAPQSTTMPSGCHVVTLTDSESFDTTHLKCITIQKLEHKWPTLVKNMSELMAPTHQDAAEHCVLNFLQLWENIISVKANLSIDETRPYYAQLDKFELLLSHSLSCTVYKQMLCLFNEALCYGSTLALQDMLPEETCKLAHQIVCHVRGFRILESLPRRQPDNMVSLIGYNGKPMVYANGTITLAHAAQSGDSEEDGAPLDLIEMDKTLLQKMVLLVLKSIAVTVKEIRSDSSDSSIDSTDYDAFQDMMLIERSIRDVLSKLETFIKQTLEFHPECHFSKILIHLFDDQDDHLIEAMVCTLDVTSGISFRNNAFPELVAMLNPVYTFLEFLKMTSNSSDLLLDLLVSNETCFLLYLLRLLKYIRMNWTMFVHSCHTFGMGSAMLDEAMGVLIRLRLQISRLVSRQLYPYDISPVLRLLESCESLYEGNELS
What is the function of this protein?
Has a dual role as a segment polarity protein and as a modulator of the Abd-B protein.  Required for Abd-B to activate the transcription of genes (including ems, cut and sal) that are involved in posterior spiracle morphogenesis.  Also required for Abd-B to form an eighth abdominal denticle belt.  Acts in a hierarchy downstream of drm and upstream of bowl during foregut and hindgut patterning and morphogenesis.  Involved in cell rearrangement during elongation of the embryonic hindgut.  Required to regulate expression of embryonic hindgut patterning genes in order to establish the large intestine and at least some rectum, and to repress small intestine fate.  Required for late wingless (wg)-dependent cell fate specification in the dorsal embryonic epidermis.  Acts in concert with wg to regulate expression of wg itself and also to regulate wg-target genes.  May have a role in ventral epidermal patterning, independent of wg signaling.
What are the official names of this protein?
Protein lines.
What is the protein family that this protein belongs to?
Belongs to the protein lines family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic in the half of the parasegment, posterior to the engrailed (en) domain, and nuclear in the half of the parasegment anterior to the en domain.
Protein: Y401_METJA
Sequence: MEMKRFLCAKCQKVIEVPYGVPKPDVCPYCGAPATFIHRIDAGGRGLGPGRGRRCGMRMMGRFRRE
What are the official names of this protein?
Uncharacterized protein MJ0401.
Protein: PYVE_ASPV1
Sequence: MDDLRQHLRGTTALVLTPDSPGYAESIKRWSDTCEKKAAAVVLPTTAEEVSLAVGFATAHHIPLVVHNGGHSTSGASASEGGLVISLARMRGVVVDPAAKTITAQGGTIWEDVDRAAAVHGLATVGGTVNHTGVGGLTLGGGYGWLTGRHGLTIDNLLAATVVLADGRILRASETANADLFWALRGAGHNFGVVTEFVFRAYDQPNEVYAGLLSYPTHRLPEILAFVNTFEDEGPAQQDQGIFFGFSGDSILAAIFYNGPRAAAERHFAPLLALQPTVNTVTMIPYEQLNTIQNPFATYGGRKSFSGAFVRLPLEVGFFQELLDDYQAMIQTYPEASRTAVLFELVSHTAVLRVPQAAMAYATRGPFYNVGCVFRWENPGLDQTMRAMQQAMMRKVGDRAGAGAHARAYANYSHHDGRVKDVFGENLPRLQQLKGKYDPNNVFKKWLNLLPN
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of pyranoviolin A, a pyranonigrin analog with a C-3 methoxy group (PubMed:33117309).  Initially, the PKS portion of pyvA synthesizes C-10 carbon chain from 5 molecules of malonyl-CoA, which is then condensed with the thiolation (T) domain-bound glycine activated by the adenylation (A) domain (PubMed:33117309).  The subsequent chain release by Dieckmann condensation (DKC) could be catalyzed by the TE domain present at the C-terminus of pyvA and/or the alpha/beta hydrolase pyvD, installing the tetramic acid moiety (Probable).  The FAD-dependent monooxygenase pyvC next epoxidizes one of the olefins of the polyketide part, and the epoxide ring-opening induces the dihydro-gamma-pyrone ring formation (Probable).  The cytochrome P450 monooxygeanse pyvB would be responsible for the 2 consecutive reactions, in which the dihydro-gamma-pyrone is oxidized to gamma-pyrone and C-7 is hydroxylated to yield pyranonigrin F (Probable).  Finally, the O-methyltransferase pyvH methylates the C-3 hydroxy group to complete the biosynthesis (Probable).
What are the official names of this protein?
FAD-linked oxidoreductase pyvE, Pyranoviolin A biosynthesis cluster protein E.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: GRC3_DEBHA
Sequence: MSAYAALQKMSGASSILYGINGESDNDESGTIGYLRNSSDEEVEAEEAEVPTTSTMAPTPNIIRTPSIVPKINSFICESNFIPNDDNFIVFHDHIIIGLKANEYILINGQSKMTIQRGAILINTGHYMFAHPNNCIPIIASQSQSLPIISSTQVVDRSGIKDSKTDENMHLFSSNYKSIIKLENLYTGLEKIGTYHPPFKRLFYSHAVIEDEDLTEYERLFKTYSFEIILRDRGCIGISIEKLWLNQIQLLISDIHEDLIPKTIMIIGNKNSGKSTLSKTLLNSLILANQNTVSYLDLDPGQSEFSMPYCLSLTNHSKPIIGMNVPKVSGDEDSVSHYYGFTTPQSQPSQYVSIIKALFREYDQVYRPRGHHLIINTPGWIKGYGKELLNELTAFINPNQLILLSNNTDNDNMDNSDNLSGLTFQNSRCFQGIYQTSKYSPFQLRMYNKLSYFHQVDTLKFDFNSHILLRSPLKLSYETVNSSKDFKGINMVSVLNYDTGLNFELNDLLSMIDTSIMGLYLIDHEYYSSLKASLKKSEDCDYLPQYLNSTDYVNLINYSSSNNIFMGLCMVHSINTKDEFFNIYLPGHNQHRLTEMITKRDYKMLLVKGDGDIPSPDLLMFDMLLKQQEDLKRLNKKRKKNPNVDDKDVLKIPYVTFENKNKIGGIWKTRRNVMRRSHQR
What is the function of this protein?
Polynucleotide 5'-kinase involved in rRNA processing.
What are the official names of this protein?
Polynucleotide 5'-hydroxyl-kinase GRC3.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. NOL9/GRC3 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DTD_KORVE
Sequence: MRTVVQRVSRASVTVEGRISGAIERGLLVLLGVGQDDAESEAEYLAEKIAGLRIFEDENEKMNLSVVDVGGAVLAVSQFTLYGDVRKGKRPSFDAAARPERAKELYEYFVAQIRAKGLRCETGVFQAMMHVELVNDGPVTILLDSKKEF
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U2_BPMU
Sequence: MMHLKNITAGNPKTKEQYQLTKQFNIKWLYTEDGKNWYEEQKNFQPDTLKMVYDHNGVIICIEKDVSAINPEGANVVEVPDITANRRADISGKWMFKDGVVIKRTYTEEEQRQQAENEKQSLLQLVRDKTQLWDSQLRLGIISDENKQKLTEWMLYAQKVESTDTSSLPVTFPEQPE
What is the function of this protein?
Chaperone involved in tail fiber assembly.  Remains associated to the tail fiber and participates in the host receptor binding.  Binds to the primary receptor (Probable).  Two alternate tail fiber assembly proteins U and U' are encoded extending the host range of the virus.
What are the official names of this protein?
Tail fiber assembly protein U', Gene product U', gpU'.
What is the protein family that this protein belongs to?
Belongs to the tfa family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Note=Tail fiber.
Protein: GCSP_PSYIN
Sequence: MTDTTLLDLLSDSKEFATRHNGSGAAQQKKMLETIGVQSIEQLIDQTVPAAIRLPEKMKLAEPQSESMTLASLKAIAEKNIVNRSFIGQGYYNTLLPNVILRNVLENPGWYTAYTPYQPEISQGRLESLLNYQQMVMDLTAMEIANASLLDEATAAAESMTLCKRAGKSKSLAFFVADGIHPQTVDVVRTRAEFFGYEIISGSMEDLDNHDLFGALLQYPSTTGNIQDLTAIIEKAHAKKTLVSVASDLLALTLLKAPGEMGADIVIGSAQRFGIPMGFGGPHAGFMATKEKFKRTMPGRIIGVSKDSKGKPALRMAMQTREQHIRREKATSNICTAQALLANMSAFYALYHGPEGLRKIARRVHHLTAILVAGLRSEGFELANQHFFDTITLNSNEHSKAIYHRALAEGMNLRKFPTPDNMPVQLGISLDETTTITDVEDLLRVITGKALSSAGFAAQVAEDEFAGIPATCRRRSKYLTHPIFNEHHSETQMMRYMKKLENKDYSLTHGMIPLGCCTMKLNAAALMLPVSWPEFSQMHPFAPTEQSFGYQELAEKLSKMLCEVTGYDGFSLQPNSGAQGEYAGLIAIHRYHQSNGEDQRNICLIPSSAHGTNPATASMLSMKVVVVGCDQQGNIDHADLKAKIDKHRDNLSCIMVTYPSTHGIYEEGIQEICEWVHEAGGQVYLDGANMNAQIGLTSPGFIGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLIPFLPGHIEVTESADNKHYAVSAAELGSASILPISYAYIAMMGEQGLTSATQIAILNANYIMERLRPHYPILYQGKEGRVAHECIIDIRPLEAASGISNEDIAKRLMDYGFHAPTMSFPVGGTFMIEPTESESTAELDRFCDAMIAIRHEIKQIEDGEWSATDNPLVNAPHTQVDLMESEWTHGYSRELACFPSKHSKDSKYWPTVNRVDNVFGDRNLICSCPSIESYMEE
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Glycine dehydrogenase (decarboxylating), Glycine cleavage system P-protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring).
What is the protein family that this protein belongs to?
Belongs to the GcvP family.
Protein: INHBE_MOUSE
Sequence: MKLPKAQLWLILLWALVWVQSTRSACPSCGGPTLAPQGERALVLELAKQQILEGLHLTSRPRITRPLPQAALTRALRRLQPKSMVPGNREKVISFATIIDKSTSTYRSMLTFQLSPLWSHHLYHARLWLHVPPSFPGTLYLRIFRCGTTRCRGFRTFLAEHQTTSSGWHALTLPSSGLRSEDSGVVKLQLEFRPLDLNSTAAGLPRLLLDTAGQQRPFLELKIRANEPGAGRARRRTPTCEPETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAGSSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS
What is the function of this protein?
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.  Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.  Inhibins appear to oppose the functions of activins.
What are the official names of this protein?
Inhibin beta E chain, Activin beta-E chain.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL29_TRIEI
Sequence: MPFPKIAEVRELSDEEIANEIAKVKRELFDLRILKATGRIEKTHLFKHNRHRLAQLLTIEKERELAKNAEASTTVSTVENTQ
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: RFAY_ECOLI
Sequence: MIQKSKIKDLVVFTDENNSKYLNVLNDFLSYNINIIKVFRSIDDTKVMLIDTDYGKLILKVFSPKVKRNERFFKSLLKGDYYERLFEQTQKVRNEGLNTLNDFYLLAERKTLRFVHTYIMIIEYIDGIELCDMPDIDDALKNKIQQSINALHQHGMVSGDPHRGNFIIKNGEVRIIDLSGKRASAQRKAKDRIDLERHYGIKNEIRDLGYYLLVYRKKMRNFMRRLKGKPAR
What is the function of this protein?
Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core.
What are the official names of this protein?
Lipopolysaccharide core heptose(II) kinase RfaY.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. RfaY/WaaY family.