PharMolix/UniProtQA huggingface dataset:
Protein: T11L1_HUMAN
Sequence: MSENLDKSNVNEAGKSKSNDSEEGLEDAVEGADEALQKAIKSDSSSPQRVQRPHSSPPRFVTVEELLETARGVTNMALAHEIVVNGDFQIKPVELPENSLKKRVKEIVHKAFWDCLSVQLSEDPPAYDHAIKLVGEIKETLLSFLLPGHTRLRNQITEVLDLDLIKQEAENGALDISKLAEFIIGMMGTLCAPARDEEVKKLKDIKEIVPLFREIFSVLDLMKVDMANFAISSIRPHLMQQSVEYERKKFQEILERQPNSLDFVTQWLEEASEDLMTQKYKHALPVGGMAAGSGDMPRLSPVAVQNYAYLKLLKWDHLQRPFPETVLMDQSRFHELQLQLEQLTILGAVLLVTFSMAAPGISSQADFAEKLKMIVKILLTDMHLPSFHLKDVLTTIGEKVCLEVSSCLSLCGSSPFTTDKETVLKGQIQAVASPDDPIRRIMESRILTFLETYLASGHQKPLPTVPGGLSPVQRELEEVAIKFARLVNYNKMVFCPYYDAILSKILVRS
What are the official names of this protein?
T-complex protein 11-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the TCP11 family.
Protein: WNT3A_MOUSE
Sequence: MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors (Probable).  Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720).  Required for normal embryonic mesoderm development and formation of caudal somites (PubMed:8299937).  Required for normal morphogenesis of the developing neural tube (PubMed:8299937).  Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720).
What are the official names of this protein?
Protein Wnt-3a.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted.
Protein: ISPG_LEPBJ
Sequence: MNFRYNHTPFGYKRRQTREVKVGDVKIGGNNPIVIQSMINSDTTDTKGTVKQILELERTGCEIVRFTVPSQVDADNLPSIRQELKKAGSKIPLVADIHFTPSVAMKAVEYVEKVRINPGNFADKKKFAVRDYTDSEYDEELERISATFSPLVLRCKELGVSMRIGTNHGSLSDRIMNRYGDTPQGMVESALEFIRIAESLNYYDIVVSMKASNPQVMVQAYRMLASRFNELKMDYPLHLGVTEAGDGKDGRIKSAIGIGSLLEDGLGDTIRVSLTEDPVLEIPVARLLAEKFNKRIVKPEPVRGYSEFRNPFTYERFYSSEIKVGTFEAGENHPVRVETVLPFENSNSFLANIAKLYQYGKSFSIEPESILIDSPSPDQLKEISEAAAALSIPVGILLGKNVSLNEKLQNELRGFPKVVFDPFLQFQDGKKMLSFLQERQNAGLYTEIHTSGAKIESFKGLPETLSEIGIKNVLFSIESKEILYDYRKLGSILSQHEFPILLHGSFSNPEEALYDSAIGIGGLLIDGIGDLIRIKTPKMKDIEEIFQLSYDLLQGTRLRLTKTEYISCPSCGRTLFNLQETTARIKSRTGHLKGVKIAVMGCIVNGPGEMADADFGYVGAGPGKVHLYRGKEIVMKNVPSEVADEKLVELIKKHGLWQDVTNV
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: RL333_SORC5
Sequence: MRDVIKLVSSAGTGHCYYTTKNKRTMTEKMQMKKYDPIARKHVIFTEGKISKGGGK
What are the official names of this protein?
50S ribosomal protein L33 3.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: RS10_PROMA
Sequence: MSTAIAQQKIRIRLKAFDRRMLDLSCDKIIETADNTAATAIGPIPLPTKRKIYCVLRSPHVDKDSREHFETRTHRRIIDIYSPSAKTIDALMKLDLPSGVDIEVKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: CH60_STAAU
Sequence: MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEATEKVGNDGVITIITIEESNRLNTELELGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSENEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNGATNEWVNMLRRGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADA_YERP3
Sequence: MSEIFDVNAAIYPFPARPVPLDTNEKAFYREKIKTLLKQRDAVLVAHYYTDPEIQALAEETGGCVADSLEMARFGNNHPASTLLVAGVRFMGETAKILNPEKKVLMPTLNAECSLDLGCPVDEFTAFCDSHPDRTVVVYANTSAAVKAKADWVVTSSIAVELIEHLDSLGEKIIWAPDRHLGSYVQKKSGADVLCWQGACIVHDEFKTQALARMKALYPDAAVLVHPESPQAVVDMADAVGSTSQLIQAAKTLPQKTLIVATDRGIFYKMQQACPDKELFEAPTAGEGATCRSCAHCPWMAMNGLRAIAEGLEQGGVMHEIHVDEELRQQALIPLNRMLDFANQLKLQVKGNA
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DKGB_YERPE
Sequence: MSIPVFGLGTFRLQDQIVIDSVSQALTLGYRAIDTAQIYENEAPVGQAIQESGINRDELFITTKIWIANLSKDKLIPSLRESIQKLKTDYVDLTLIHWPSPNDEVSVAEFMSELLKAKGLGLTRQIGISNFTIDLMKQAIAAVGAEEIATNQIELSPLLQNRNVVDFAKQNGIAVTSYMTLAYGKALAEPVIKTIAEQHGATPAQVILSWAMQLGYGVIPSSTKAANLASNLLAQKLCLNAADMALIATLDRNERLVSPDGLAPKWD
What is the function of this protein?
Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
What are the official names of this protein?
2,5-diketo-D-gluconic acid reductase B, 2,5-DKG reductase B, 2,5-DKGR B, 25DKGR-B, AKR5D.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_PROMS
Sequence: MIGGKKKCIGLIFGGNSNEHEVSISSAKTVFQAFKSEINKERFTIRAFYINKYGDWLDSDSSEKILIDESKNKNTTKKQIFNQEKINFLDGVDFQNVDVWFPLLHGINGEDGSIHGLLRFTKKPLVGCGIIGSALGMDKILMKIIFSNLKIPQVNYLVFQNQDLNDEEVKNKLIHEILKKLNFPVFVKPSNSGSSLGISKVINKSEIIPALEKARGIDPSILIEEGLEVREIECGIIGNSKLLTSEIGEVNYKSDWYDYNSKYHSNNKIIIPAEIDSKISKEIKEIAIKSCRALNIFGFARVDFFLEKSSNKIFLNEINTIPGFTKNSMFPMLWKASGLKIEQLVAKLVDISLDL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_METAC
Sequence: MDTKKFRGSRTCGGGTHKNRRGAGNRGGRGKAGGCKHHFVRAMMRGYSYGKHGFKRPDEVSRDVSIVNVGELDELASYLVEEGLAEVKDGAYHINLENLGIEKVLGSGRVTKNLVVTSEEFSASAREKIENAGGSCIDAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: GPTC4_XENLA
Sequence: MSASSVKKSQGMKFAEEQMHKHGWKEGKGLGRRENGICEAIKVKVKCDHAGVGHNSAEQFTFHWWDHVFNKTASSISVEADQDGVTVNRVKDEDAPVTNKKPRKALSNKNMLYGRFVKSATLLSGGEQPVKEPSSSESSDSSGDEDEKLDLSSATKLTDEDLKKVCGGRTAHKGARHGLTMSAKLSRLEEQEREFLAKYGKKEQKNKERDEKLERTQGLPGMNIQQIYSEEGIETNISHESSQHKKKKKKRKRADSERKEESQENGHEEEQMPPSEQEVKSSKKKKSKKKQREESPSTQEEQPTESSDFSMKPKKKKKKKNKSE
What are the official names of this protein?
G patch domain-containing protein 4.
Protein: DXS_WOLSU
Sequence: MNLKGKTLKELEEVSLSIRERILEVVSHNGGHLSSTLGAVELIVGMHAVFDSSRDPFIFDVSHQAYAHKLLTGRWEEFATLRQFEGVSGFTKPSESEHDYFIAGHSSTSISLAVGAAKAISLSLEKNRMPVVLIGDGSMSAGLCYEALNELGDRKYPMVILLNDNEMSIAEPIGAISKYLSQAIAGRFFQSIKGKVEKLLAHLPEGASYMAKRFEESLKLITPGILFEELGLEYIGPIDGHNLKEIIETLRIAKAMNKPVIIHAQTLKGKGYKIAEGPREHWHGVGPFDLSSGEPLKKPCSSSPTDIFSRTLLELAKEDEKVVGVTAAMPSGTGLSALVHEFPNRFWDVAIAEQHAVTSMAALAKEGYKPFVAIYSTFLQRAYDQIIHDVGIMKLPVKFAIDRGGIVGEDGETHQGILDIGYLRLIPHMTLMAPRSNESLKEAVKFAKDFSLGPIAFRYPRKSFVLQEGIFSESPFLYGKAERLMEGKDEVLFVGFGNGVGRAYEVSKVMASEYEVGLVDLRFVKPLDHETLWELSKEYRYWLVFSDASKVGGVASALLEWKAEVGAEVEILSMELEDEYIQHGKVEQVEEEIGFDVKGLSQKVRERLERIANSQRLLV
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: PME52_ARATH
Sequence: MPCLFIFIALLLSSCIGTLKALDQTCGNKVVNTIVVDQAGSGEGQRVTTITYNGHAATDVSSTFTSYPSHIVVRNLSIMNTYNRLTSLTKANGMSWDIKPAVAISVYGDKSAFYNCDFLGLQDTVWDNLGRHHFKNCYIEGAIDFIFGSGQSVYEDCHINATAGALASKVSFGYITAQGRSSDSDPSGFVFLRGSVSGSTSVYLGRAYGPFSRVIFIQTDLSSVVHPEGWYSWHYGGYEMSFTYAEVECKGAGSDMSRRVPWIDKLHSFYTKQQFSISNFIDQDQWISNIPRF
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
What are the official names of this protein?
Putative pectinesterase 52, PE 52, Pectin methylesterase 52, AtPME52.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: NDPA_SHIFL
Sequence: MSLDINHIALHQLIKRDEQNLELVLRDSLLEPTETVVEMVAELHRVYSAKNKAYGLFSEESELAQTLRLQRQGEEDFLAFSRAATGRLRDELAKYPFADGGFVLFCHYRYLAVEYLLVAVLSNLSSMRVNENLDINPTHYLDINHADIVARIDLTEWETNPESTRYLTFLKGRVGRKVADFFMDFLGASEGLNAKAQNRGLLQAVDDFTAEAQLDKAERQNVRQQVYSYCNEQLQAGEEIELESLSKELAGVSEVSFTEFAAEKGYELEESFPADRSTLRQLTKFAGSGGGLTINFDAMLLGERIFWDPATDTLTIKGTPPNLRDQLQRRTSGGN
What are the official names of this protein?
Nucleoid-associated protein YejK.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ATPL_BACC0
Sequence: MSLGVIAAAIAIGLSALGAGIGNGLIVSRTIEGVARQPELKGALQTIMFIGVALVEALPIIGVVIAFIVMNK
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SPNXC_HUMAN
Sequence: MDKQSSAGGVKRSVPCDSNEANEMMPETSSGYSDPQPAPKKLKTSESSTILVVRYRRNVKRTSPEELVNDHARENRINPLQMEEEEFMEIMVEIPAK
What are the official names of this protein?
Sperm protein associated with the nucleus on the X chromosome C, Cancer/testis antigen 11.3, CT11.3, Cancer/testis-associated protein CTp11, Nuclear-associated protein SPAN-Xc, SPANX-C, SPANX family member C.
What is the protein family that this protein belongs to?
Belongs to the SPAN-X family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Associated with nuclear craters.
Protein: SCPB_CLOB6
Sequence: MNKDHEEQLEINEVSQKNKYKSIIESLLFMSGEPINIKDLATILNCKQDKVSSLLNEMKNSYVGKDRGIKILIHNRAVQLVTKPENSIYVEKLLKTNVRQSLSQAALETLSIIAYKQPITRVAIDEIRGVKSDRAIYTLLEKNIIKECGRLDVPGKPILYGTTEEFLKFFGLDSIEAIPNLEDLLKEFSKEEN
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: TRUB_STAAB
Sequence: MYNGILPVYKERGLTSHDVVFKLRKILKTKKIGHTGTLDPEVAGVLPVCIGNATRVSDYVMDMGKAYEANVSIGRSTTTEDQTGDTLEMKGVHSADFNNDDIDRLLENFKGVIEQIPPMYSSVKVNGKKLYEYARNNETVERPKRKVNIKDIGRISELDFKENECHFKIRVICGKGTYIRTLATDIGVKLGFPAHMSKLTRIESGGFVLKDSLTLEQIKELHEQDSLQNKLFPLEYGLKGLPSIKIKDSHIKKRILNGQKFNKNEFDNKIKDQIVFIDDDSEKVLAIYMVHPTKESEIKPKKVFN
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: IMDH_BACSU
Sequence: MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNIPVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFLTPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKEELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIHGRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNIIAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMGSVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKDLRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS
What is the function of this protein?
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
What are the official names of this protein?
Inosine-5'-monophosphate dehydrogenase, IMP dehydrogenase, IMPD, IMPDH, Superoxide-inducible protein 12, SOI12.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family.
Protein: SYT10_RAT
Sequence: MSFRKEDGVSSLCQKALHIITELCFAGQVEWDKCSGIFPADRSGQGGGGTDISVSLLAVVVSFCGLALLVVSLFVFWKLCWPCWKSKLVAPNVSTLPQSISSAPTEVFETEEKKEVEENEKPAPKAIEPAIKISHTSPDIPAEVQTALKEHLIKHARVQRQTTDPTSSSRHNSFRRHLPRQMNVSSVDFSMGTEPVLQRGETRTSIGRIKPELYKQKSVDSEGNRKDDVKTCGKLNFALQYDYENELLVVKIIKALDLPAKDFTGTSDPYVKIYLLPDRKKKFQTRVHRKTLNPLFDELFQFPVVYDQLSNRKLHFSIYDFDRFSRHDMIGEVILDNLFEVSDLSREATVWKDIHCATTESIDLGEIMFSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNPVYNEAIIFDIPPENVDQVSLCIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYHRKPITHWHPLLELPGRATSFDSQGSCSSPRPPSTP
What is the function of this protein?
Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb.  Exocytosis of IGF1 is required for sensory perception of smell.  Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity).  Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:18508778).
What are the official names of this protein?
Synaptotagmin-10, Synaptotagmin X, SytX.
What is the protein family that this protein belongs to?
Belongs to the synaptotagmin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein. Note=Localizes to neuronal vesicles containing IGF1 that are not enriched at synapses. Does not colocalize with synaptic vesicles or with the Golgi apparatus.
Protein: ARF2A_SOLLC
Sequence: MAASEVSIQGYSEPSDGSRPVSETGRSSSGVGIVDADTALYTELWRSCAGPLVTVPREGELVYYFPQGHIEQVEASTNQVADQQMPLYNLPSKILCRVVNVLLKAEPDTDEVYAQVTLMPEPNQDENAVKKEPMRPPPPRFHVHSFCKTLTASDTSTHGGFSVLRRHADECLPQLDMSRQPPTQELVAKDLHGNEWRFRHIFRGQPRRHLLQSGWSVFVSSKRLVAGDAFIFLRGENGELRVGVRRAMRQQGNAPSSVISSHSMHLGVLATAWHAIQTKTMFTVYYKPRTSPAEFIVPYDHYMESVKNNYSIGMRFKMRFEGEEAPEQRFTGTIVGIEDADPQRWLESKWRCLKVRWDENSSIPRPDRVSPWKIEPALSPPALNVPPVARPKRPRSSILPTSPDSSVLTREGSSRATADHSQASGFPRVLQGQELSTFRGGFAEINETDLSEKPMIWQTSVNDEKNDIHSASKRYLPDKWLPLGRPESSLTDLLSGFGSSHGFCLPSADQAAFGARLVKQQTQDQEKDFSLLGKPWSLLSSGLSLNLMDSGSKAPGIGGDTPYQMRGDARYSGYGEFSVLPGHRVANQQGSWIMPQPVSPYMQLSSHSREMMHKPSVVKQPEAVKPKEGNYKLFGIPLTSNVCTDAVMMRKSSLIDPASDMNIGIHPHQSLATDSDQRSEQSKGSKVDDGVAANDHDKQFHTFHLAARDKDGKGHSSSTRSCTKVHKQGTALGRSVDLAKFNNYDELIAELDQLFDFNGELKARSKSWLVVYTDDEGDMMLVGDDPWQEFCGMVRKIFIYTKEEVQRMNPGTLNSKGEDTSSVAEGSDAKEVKNLQLPSESGQAES
What is the function of this protein?
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs) (By similarity).  Could act as transcriptional activator or repressor (PubMed:26959229, PubMed:26716451, PubMed:27645097, PubMed:28167023).  Involved in the control of fruit ripening process (PubMed:26959229, PubMed:26716451, PubMed:28167023).  Regulates expression of a number of ripening regulators, transcription factors, and ethylene biosynthesis and signaling components (PubMed:26959229, PubMed:26716451).  May act as a transcriptional repressor of auxin-responsive genes (PubMed:26716451).  Regulates vegetative growth, lateral root formation and flower organ senescence, possibly partially by regulating gene expression of auxin and ethylene response factor (ERF) genes (PubMed:28167023).  Plays a negative role in axillary shoot meristem formation (PubMed:27645097).
What are the official names of this protein?
Auxin response factor 2A, SlARF2A.
What is the protein family that this protein belongs to?
Belongs to the ARF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KLF1_CAEEL
Sequence: MTSSSINATSSREPLIHIPNKPSLSIDPLARADRSVHLSPSFFQPGLSSISSENDDAEQRIHEATRSFNQFGHQFYESIRELSESTSAYERLKANALRRKLENTFGNDSGAATSSSSSSVFERQSDFSAFAPYKNSHFDSTQSLFQPTTSFNDRLEQIKSDFIAEHQKSMSSFSGFNTPTTALGAAFQGMQVKKSAFAPVLLRENLDTRRPGGHLISDILNRDPLPQSRNLNLNMARNVPIRLIHSTSNFDIASSSSGDSGHQDHESIVVEDADMDSPTSPCVKRSAMNFDLRDEPLTVNVESVSSTSDLPSSVSSSVNSFVYQNFDPLEFKRKIDELTASACLAVMPDANGQVDPMAIKTQLDAIKKQMEEHQTHMAEASQRLHVDSSLEDSNCEPSPSSSYDASEPSVKRLHHCTHPNCGKVYTKSSHLKAHFRTHTGEKPYECSWDGCDWRFARSDELTRHYRKHTGDRPFKCSQCSRAFSRSDHLSLHMKRHF
What is the function of this protein?
Transcription factor which modulates genes involved in lipid metabolism and the phase I detoxification pathway, including cytochrome P450 oxidases (PubMed:18680432, PubMed:24805825, PubMed:31346165).  Required for diet restriction- and mitochondrial dysfunction-mediated lifespan extension, perhaps acting in a ubiquitination-dependent manner (PubMed:24805825, PubMed:31346165).  Involved in the response to oxidative stress (PubMed:31346165).  Plays a role in cell death (PubMed:18680432).
What are the official names of this protein?
Kruppel-like factor 1.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localized to nucleus at the larval L4 stage, becoming cytoplasmic during early adulthood. Translocation to the nucleus dependent, in some circumstances, on oxidative stress.
Protein: RS8E_METAC
Sequence: MRWQGSSRRKATGGKVITARGKRKFEMGRESAETRISEIKRKKVPTMGGNRKVRLLQSNVANVTNPKDGKTVTAPIETVIDNTANKHYVRRNILTKGSVIRTSMGTARVTSRPGQDGVVNAVLIE
What are the official names of this protein?
30S ribosomal protein S8e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS8 family.
Protein: E1BS_ADE04
Sequence: MEIWTVLEDFHKTRQLLENASNGVSHLWRFCFGGDLAKLVYRAKQDYREQFEDILRECPSLFDALNLGHQSHFNQRISRALDFTTPGRTTAAVAFFAFIFDKWSQETHFSRDYQLDFLAVALWRTWKCQRLNAIPATCRYSR
What is the function of this protein?
Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis.  Without E1B 19K function, virus production is compromised because of premature death of host cell.  Interacts with Bax protein in cell lysates (By similarity).
What are the official names of this protein?
E1B protein, small T-antigen, E1B 19 kDa protein, E1B-19K.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E1B 19 kDa protein family.
What are the subcellular locations of this protein?
Host cell membrane. Host nucleus envelope. Host nucleus lamina. Note=Associated with the plasma and nuclear membranes, and with the insoluble nuclear lamina.
Protein: RL32_FRATM
Sequence: MAVQQVKKSRSKRDMRRSHDSLTNPTLSTDKSTGELHLRHHVSPNGFYKGRKVVDTKSED
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: IL3_HUMAN
Sequence: MSRLPVLLLLQLLVRPGLQAPMTQTTPLKTSWVNCSNMIDEIITHLKQPPLPLLDFNNLNGEDQDILMENNLRRPNLEAFNRAVKSLQNASAIESILKNLLPCLPLATAAPTRHPIHIKDGDWNEFRRKLTFYLKTLENAQAQQTTLSLAIF
What is the function of this protein?
Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442).  Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated (PubMed:10779277, PubMed:32889153).  In addition, plays an important role in neural cell proliferation and survival (PubMed:23226269).  Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation (PubMed:12816992).  Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (PubMed:29374162).  Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity).  Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (PubMed:27862234).
What are the official names of this protein?
Interleukin-3, IL-3, Hematopoietic growth factor, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor.
What is the protein family that this protein belongs to?
Belongs to the IL-3 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGC_METS3
Sequence: MYNVAIVGASGYTGGELLRMLLNHSEVEVNNITSRKYDGTPAHKIHPHIRDSGLVFKNKQPSELDADIIFTATPHGASMKIVPDLLETGTKVIDLSGDYRYRDTKVYEKWYGLEHTSDIKGVYGLPEIYRDEIKKADLVGNPGCFPTGAILSSYPLVDNDLVDRIVIDSKTGVSGAGVNPSSTTHYPNIADNVNPYKISSHRHVSEIQQELHGFEDVKVSFTPHLVPVIRGIQTTSHSFLREEHSDITPDELRKFYEKTYGKEYFIKLMDDGEIPHLSSVRGSNFVHIGGFEIDDTGRIVMLSCIDNLVRGASGQAIQNMNIMLGLDETTGLNHFGLNP
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.