PharMolix/UniProtQA huggingface dataset:
Protein: ERMIN_PONAB
Sequence: MTDVPATFTQAECNGDKPPENGQQPITKISEELTDVDSPLPHYRVEPSLEGAPTKGSQEERRKLQGNMLLNSSMEEKILKENPEEKLFVVHKAITDLSLQETSADEMTFREGRQWEKIPLSGSNQEIRRQKERITEQPLKEEEDEDRKNKGHQAAEIEWLGFRKPSQADMLHSKHDEEQKVWDEEIDDDDDDNCNDDEDEVRVIEFKKKHEEVSQFKEEGDASEDSPLSSASSQAVTPDEQPTLGKKSDISRNAYSRYNTISYRKIRKGNTKQRIDEFESMMHL
What is the function of this protein?
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult.  May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity).
What are the official names of this protein?
Ermin, Juxtanodin, JN.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL7_CAMJD
Sequence: MAISKEDVLEYISNLSVLELSELVKEFEEKFGVSAVPVMVAGGAAAGGAAAAAEEKTEFDIVLTDGGAKKIEVIKIVRALTGLGLKEAKDAVEQTPSTLKEGVAKAEAEEAKKQLEEAGAKVELK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: KAAG1_HUMAN
Sequence: MDDDAAPRVEGVPVAVHKHALHDGLRQVAGPGAAAAHLPRWPPPQLAASRREAPPLSQRPHRTQGAGSPPETNEKLTNPQVKEK
What are the official names of this protein?
Kidney-associated antigen 1, RU2 antisense gene protein.
Protein: CWP15_SOLLC
Sequence: MEKGYYDLES
What are the official names of this protein?
62 kDa cell wall protein.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: LRGB_BACHK
Sequence: MASTMTPYFGIVVSLIAYGIGTLLFKHSKGFFLFTPLFVAMVLGIVFLKVGNFTFEEYNTGGKMISFFLEPATIAFAIPLYKQVDKLKKYWWQILSAIVVGSICSVIVVFIVAKAIGLDTAVMNSMLPQAATTAIALPISESIGGIPAITSFAVIFNAVIVYALGALFLKTFRVKHPIAKGLALGTAGHALGVAVGIEMGEVEAAMASIAVTVVGVVTVVVIPMFMPFIG
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA.  The LrgAB and CidA proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. LrgB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HAM_DROME
Sequence: MDAFFKDRAQAEHILQEWVRRREPVCELDIRDSGGVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMVVDGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNFRDSPSSSGIAEREEYFDDIRKFMNRVYTPNSLAGNEGDTEEYPNSDDQSVNLEKDSGNFNNNSSNISNNNSSSGNNNNSSKAITISS
What is the function of this protein?
Transcription factor that plays a crucial role in external sensory organ (ESO) that elaborates from a single precursor cell (ESOP cell).  Mediates the differentiation of lineage branch that generates the internal 'ES' and 'th' cells (external sensory neuron and thecogen cells, respectively) from the IIIB cell.  Its absence leads to re-specification of IIIB daughter cells into external tormagen cells (tr cells), or internal multidendritic neurons (MD cells).  One of its role in the development of the ESO lineage is to modulate the activity of Notch and PAX2 signals.
What are the official names of this protein?
Transcription factor hamlet.
What are the subcellular locations of this protein?
Nucleus.
Protein: DJC15_MOUSE
Sequence: MATGGGVTSREGLRYAEYLPPSAQRSDADIDHTAGRRLLAVGLGVAAVAFAGRYAFQIWKPLEQVITATARKISSPSFSSYYKGGFEQKMSKREASLILGVSPSAGKAKIRTAHKRIMILNHPDKGGSPYLASKINEAKDLLEASSKAN
What is the function of this protein?
Acts as an import component of the TIM23 translocase complex.  Stimulates the ATPase activity of HSPA9 (By similarity).  Negative regulator of the mitochondrial respiratory chain.  Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP.
What are the official names of this protein?
DnaJ homolog subfamily C member 15.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: URED_BRUSI
Sequence: MLIINDNNLSGPLQRVNGTGELSVQFKDGRSRISRLYQEGAAKIRMPQAVTGPLEAILINTSGGLTGGDRLKWDVALDDGASAVITTQACERIYRSGGGEARIATRLKAAKGTRLAWLPQETILFNRSILSRRLDVELEEGAQMLVVEATVFGRLAMGERVVAARFADRWRVRLGGRVIHAEEFRLGPDVGAELQAPAVAGGACAMATVLMVCEQAGRHLETARAIIGEEGGCSLWRVGKASKLVVRLYAPDSYALRRRLCPLVALLNGKAGLPKVWTI
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BCP1_YEAST
Sequence: MVQAIKLNDLKNRKRKNVEEENGSDESEIDISSTDSENEEEQNGEEEIVNIDFDFFGGNPEVDFHALKNLLRQLFGPQESTRIQLSSLADLILGSPTTTIKTDGKESDPYCFLSFVDFKANHLSDYVKYLQKVDMRLSTFFKTMIDSGNKNCALVLSERLINMPPEVVPPLYKITLEDVATALGDDKHYDFYIIVTRKYEVNFDTDDDTDSGKRNKNKDERSKKRVKADEVDYFHEEDRFFEKYAKIHFESEAKKGVISSYMILDHEGLVKSIDELETEISTW
What is the function of this protein?
Involved in nuclear export of the lipid kinase MSS4 and of the 60S ribosomal subunit.  May also play a role in directing MSS4 to the plasma membrane.  Plays a role in actin cytoskeleton organization and vesicular transport.
What are the official names of this protein?
Protein BCP1.
What is the protein family that this protein belongs to?
Belongs to the BCP1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL18_XYLFA
Sequence: MSIGKNVARLRRAKSTRVHIRKLGVPRLSVLRTGRHLYAQIFTADGSKVIAAANTLQSQVKDGLKNGKNSLAATKVGKLIAERAKAVGVDRIAFDRSGYLYHGRIKILADAARDAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: MRAY_BURTA
Sequence: MLLALAQWLQGDASFLRLFTYLTFRAVMATITALVIGLVCGPWVIRKLTQMKVGQAVRKDGPQTHLVKSGTPTMGGVLILIGIAVATLLWGDLTNRFIWIVMLVTFGFGVIGWVDDYRKVVYKDPRGMSSREKYFWQSVIGLFAAVYLAFSVSEANNVRVFDLFMAWVRSGLSMGLPARADLMLPFLKSISYPLGVWGFIALTYFVIVGASNAVNLTDGLDGLVIMPVVLVGASLGVFAYVMGSAVYSKYLLFPHIPGAGELLIFCSAMGGAGLAFLWYNTHPAQVFMGDVGALALGGALGTVAVIVRQEIVLFIMGGIFVAETLSVMLQVTWFKYTKKRYGEGRRIFKMAPLHHHFELSGWKETQVVVRFWIITLMLCLFGLSTLKLR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL10_THET2
Sequence: MPNKRNVELLATLKENLERAQGSFFLVNYQGLPAKETHALRQALKQNGARLFVAKNTLIRLALKELGLPELDGLQGPSAVVFYEDPVAAAKTLVQFAKSNPKGIPQVKSGLLQGQILTAKDVEALAELPTMDELRAELVGVLQAPMAELVGVLGGVARELVGILEAYAEKKAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: GATB_BACVZ
Sequence: MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGYPGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGENGWIEIEVGGKTKKIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRTPEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEKFGTKTELKNLNSFAFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDLVELYIDDEWKERVRATIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVNKGAEAKQASNWLMGEVSAYLNAEQKELEDVALTPEGLAGMIKLIEKGTISSKIAKKVFKELIEKGGDAEKIVKEKGLVQISDESVLLKLVTDALDSNPQSIEDFKNGKDRAIGFLVGQIMKASKGQANPPMVNKILLEEIKKR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: YIDC_XYLFA
Sequence: MNQTRVLLIFSWLTVATLLWMDWGKNKNETLEISASQNLGVDSNLELEHAVPQINAGAVPVQKDSQLIAVAPKVPVINVKTDVLQLKLDGFSVLAADLLRFPQSKDRGAKPIKLLTDDPNYPYSATTGWVSQSNSPVPNLSTFLPEQPGVSYKLANDQDRLVVPFVWTAANGVSIRRTFTFERGRYAILIRDEIRNGGETPWNAYVFRKLSRVPIPNILNRAMTNPDSFSFNGAVWYSEKGGYERRAFKDYMNDGGLNREIGGGWIALLQHHFFTAWIPQKDQASLYLLAQNGSRDIAELRGPAFTVAPGQSTTTEARLWVGPKLVEQITKEHVKGLDRVVDYSRFQLMALIGQGLFWILSHLNSLLHNWGWAIVGLVVLLRIAMYPLSAAQYKSAAKMRKFQPRLQQLKERYGEDRQKFQQAMMELYKKEKINPMGGCFPILIQMPIFFALYWVLVESVELRQAPWLGWIQDLTTRDPYFILPLLNIVIMWATQKLTPTPAGMDPIAGKMMQVMPLIFGVMMAFVPSGLALYWVINGGLNLLIQWWMIRQHADFSRKRSRGNIK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCPB_UREPA
Sequence: MNNDKKNKKNLLNNELDLAKYTLHNLSADNNDDENELELDWDGIDDEIIDNNQQIYQKKHINHKTRLFIEKDDKLNNHEQIESGNEIINQPKALSGQDFLEFVNSKLVQKNNNFKQNSKFLQNQLTNHELLREKLKPQEDFNKIFKTKDINVTEEIKIKDVKKNSSVSFRNSFNINDLNQNQITNIKSIIDSTLFLAGEEGVSLQDLKRTTGLNESSQLKTILNQLQKDYDVDDSGLVLVQFGEKFKLLTQSKNKDALSKFVTTSFRTPLSQRNLETLAIIAYNQPTTRAKIQAIRDRDPKPAIDALLKLNLIIEAGRQDTPGHPILYTVSQKFYDLFGIRNLTELPRLNKEINEFSPIDESTN
What is the function of this protein?
Participates in chromosomal partition during cell division.  May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity).
What are the official names of this protein?
Segregation and condensation protein B.
What is the protein family that this protein belongs to?
Belongs to the ScpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.
Protein: 4EBP2_HUMAN
Sequence: MSSSAGSGHQPSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIEDSKVEVNNLNNLNNHDRKHAVGDDAQFEMDI
What is the function of this protein?
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (PubMed:30765518).  Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation.  In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:30765518, PubMed:25533957).  EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity).  Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 4E-binding protein 2, 4E-BP2, eIF4E-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the eIF4E-binding protein family.
Protein: AROA_PELPB
Sequence: MRVFKGEVTALPPDKSISHRAALIGALSEGTTEIMNFSGGFDNQSTLGVLKDAGITLRQELLEGADGRTVRQVIIESKGLWSFQPPSAPLMCNNSGSTMRMFAGILAAQPFASELIGDSSLMKRPMKRVADPLRQMGADLQLSPSGTAPICIKGSKELKPINYRLPVPSAQVKSLVAFAALHADGESRIIESVRSRDHTEVMLGLDSFEQDGERVIVVPGRKTVAAKPFYIPADPSAACFIVALGLLARGSEIIIRDVCLNPTRAAFLNILTDAGACLTIENQRVIGGETIGDILVENHAALEPLLITDPQLVAFIIDEIPMLAVLSAFASGRFELHNAAELRTKESDRIDALVVNLQRLGFDCEQYPDGFVVKGRRITPSGTVVIDSFDDHRIAMSFAIAGKATGCPIDLSDIDVVGVSFPNFFDLLDSLQV
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHOSP_RABVS
Sequence: MSKIFVNPSAIRAGLADLEMAEETVDLINRNIEDNQAHLQGEPIEVDNLPEDMGRLHLDDGKSPNHGEIAKVGEGKYREDFQMDEGEDPSFLFQSYLENVGVQIVRQMRSGERFLKIWSQTVEEIISYVAVNFPNPPGKSSEDKSTQTTGRELKKETTPTPSQRESQSSKARMAAQIASGPPALEWSATNEEDDLSVEAEIAHQIAESFSKKYKFPSRSSGILLYNFEQLKMNLDDIVKEAKNVPGVTRLAHDGSKLPLRCVLGWVALANSKKFQLLVESDKLSKIMQDDLNRYTSC
What is the function of this protein?
Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication.  Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA.  Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus.  Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).  Inhibits interferon induction pathways by interacting with host TBK1 and preventing the formation of dynamic cytoplasmic condensates that have liquid properties and that are essential for interferon production (PubMed:36640307).
What are the official names of this protein?
Phosphoprotein, Protein P, Protein M1.
What is the protein family that this protein belongs to?
Belongs to the lyssavirus protein P family.
What are the subcellular locations of this protein?
[Phosphoprotein]: Virion. Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P2]: Host cytoplasm. SUBCELLULAR LOCATION: [Isoform P3]: Host nucleus. SUBCELLULAR LOCATION: [Isoform P5]: Host nucleus.
Protein: ALDH_VIBHA
Sequence: MNPQTDNVFYATNAFTGEALPLAFPVHTEVEVNQAATAAAKVARDFRRLNNSKRASLLRTIASELEARSDDIIARAHLETALPEVRLTGEIARTANQLRLFADVVNSGSYHQAILDTPNPTRAPLPKPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAAGCPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLLQGNQRALGQALVSHPEIKAVGFTGSVGGGRALFNLAHERPEPIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMGCGQFCTKPGVVFALNTPETQAFIETAQSLIRQQSPSTLLTPGIRDSYQSQVVSRGSDDGIDVTFSQAESPCVASALFVTSSENWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEMLAGSLTATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEVGYAMVHGGPYPASTHSASTSVGAEAIHRWLRPVAYQALPESLLPDSLKAENPLEIARAVDGKAAHS
What is the function of this protein?
Catalyzes the oxidation of long-chain aliphatic aldehydes to acids.  May be implicated in controlling luminescence as it catalyzes the oxidation of the fatty aldehyde substrate for the light-emitting reaction.
What are the official names of this protein?
NADP-dependent fatty aldehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
Protein: GATA_SYNP2
Sequence: MSAIRTLHQQLIAKERSAVEILTETFAHIEAVEPKVKAFLTLTKEQALAQAAQVDAKIAAGETIGLLEGIPIAIKDNLCTKGIQTTCASRILEGFVPTYESTVTQELQEAGAIMVGKTNLDEFAMGSSTENSGYQVTGNPWDVTRVPGGSSGGSAAAVAAGEAPIALGSDTGGSIRQPASLCGVVGLKPTYGLVSRFGLVAYASSLDQIGPFARTVEDTAILLEAIAGHDPKDSTSLDVDIPQYSQLLQPELPKDKPLKIGIIQETFGEGLDPEVAEAVQKAIAQLQELGAEVETISCPRFRYGLPAYYIIAPSEASANLARYDAVKYGTRNAAADNLVDMYTQTRAAGFGPEVKRRIMLGTYTLSAGYYDAYYLKAQKVRTLIKKDFDQAFAKVDVLICPTSPSTAFKAGEKTDDPLSMYLSDLMTIPVNLAGLPALSLPCGFDAQGLPIGMQLIGNVLREDLLLQVAHVYEQATAWHQKQPQL
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: DHI2_BOVIN
Sequence: MESWPWPSGGAWLLVPARALLQLLRADLRLGRPLLAALALLAALDWLCQRLLPPLAALAVLAATGWIVLSRLARPQRLPVATRAVLITGCDSGFGNATAKKLDTMGFTVLATVLDLNSPGALELRACCSSRLKLLQMDLTKPGDISRVLEFTKVHTPSTGLWGLVNNAGQNIFVADAELCPVATFRTCMEVNFFGALEMTKGLLPLLRRSSGRIVTVSSPAGDMPFPCLAAYGTSKAALALLMGNFSCELLPWGVKVSIIQPACFKTESVKDVHQWEERKQQLLATLPQELLQAYGEDYIEHLNGQFLHSLSQALPDLSPVVDAITDALLAAQPLRRYYPGHGLGLIYFIHYYLPEGLRQRFLQSFFISPYVPRALQAGQPGLTSARDIAQDQGPRPDPSPTAQ
What is the function of this protein?
Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+) (PubMed:10822012, PubMed:17470521, PubMed:26519454).  Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:10822012).  Affinity towards corticosterone is higher than cortisol or dexamethasone (PubMed:10822012).  Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (By similarity).  Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen.  Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone.  Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro.  7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity).  May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol (PubMed:17470521, PubMed:26519454).
What are the official names of this protein?
11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, 11-beta-HSD2, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Microsome. Endoplasmic reticulum.
Protein: NQRE_HAEDU
Sequence: MEHLLSIFVKSVFIENMALSFFLGMCTFLAVSKKVSTAFGLGIAVIVVLGIAVPVNQLVYTHILKDGVLVDGVDLSFLNFITFIGVIAALVQILEMILDKFFPALYSALGIFLPLITVNCAIFGGVSFMVQREYDLVESVVYGIGAGTGWMLAIVALAGLTEKMKYSDVPAGLRGLGITFITVGLMALGFMSFSGIQL
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit E, Na(+)-NQR subunit E, Na(+)-translocating NQR subunit E, NQR complex subunit E, NQR-1 subunit E.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VPC35_MYCTO
Sequence: MIYLETSALVKLIRIEVESDALADWLDDRTELRWITSALTEVELSRAIRAVSPEGLPAVPSVLARLDRFEIDAVIRSTAAAYPNPALRSLDAIHLATAQTAGSVAPLTALVTYDNRLKEAAEALSLAVVAPGQAR
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  An RNase.  Its toxic effect is neutralized by coexpression with cognate antitoxin VapB35 (By similarity).
What are the official names of this protein?
Ribonuclease VapC35, RNase VapC35, Toxin VapC35.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
Protein: MT1_RAT
Sequence: MDPNCSCSTGGSCTCSSSCGCKNCKCTSCKKSCCSCCPVGCSKCAQGCVCKGASDKCTCCA
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
What are the official names of this protein?
Metallothionein-1, MT-1, Metallothionein-I, MT-I.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: PYRF_KLULA
Sequence: MSTKSYTSRAETHASPVASKLLRLMDEKKTNLCASLDVRSTDELLKLVETLGPYICLLKTHVDILDDFSYEGTVVPLKALAEKYKFLIFEDRKFADIGNTVKLQYTSGVYRIAEWSDITNAHGVTGAGIVAGLKQGAQEVTKEPRGLLMLAELSSKGSLAHGEYTKGTVDIAKSDKDFVIGFIAQNDMGGREEGFDWLIMTPGVGLDDKGDALGQQYRTVDEVVSGGSDIIIVGRGLFAKGRDPKVEGERYRNAGWEAYQKRISAPH
What are the official names of this protein?
Orotidine 5'-phosphate decarboxylase, OMP decarboxylase, OMPDCase, OMPdecase, Uridine 5'-monophosphate synthase, UMP synthase.
What is the protein family that this protein belongs to?
Belongs to the OMP decarboxylase family.
Protein: RL24_HYDS0
Sequence: MAFKIKRGDKVKVLAGKDRGKISTVEFLDSKSGKAIVKNINIAKKHVKAIEGRREGGIYEIELPMPISKVMLVCPKCEKPTRVGFRIEEKDGVVRKYRYCKKCNENIDLVYEKNKVKR
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.