PharMolix/UniProtQA huggingface dataset:
Protein: PYRB_STRSY
Sequence: MTITNGKVSLKHLVTMETLSNEEVLGLIQRGIAFKRGEKVELDRKYYASNLFFEDSTRTHKSFEMAELRLDMGMIDFDARTSSVNKGETLCDTILTMSALGVDICVIRHSEVDYYKQLIDSPTIQTSIVNGGDGSGQHPSQSLLDLMTIYEEFGTFDGLKIAIAGDITHSRVAKSNMQILKRLGAEIFFAGPEEWYAEEFDVYGQHLNIDDIVETVDVLMLLRVQHERHDGDGGFSKETYNRLHGLTEERYKRLKDTAIVMHPAPVNRDVEIDDSLVEAPKSRIVRQMQNGVFVRMAILEAIVNGKA
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: SECA_SHESW
Sequence: MFGKLLTKVFGSRNDRTLKGLQKVVIKINALEADYEKLTDEELKAKTAEFRERLAAGETLDDIMAEAFATVREASKRVFEMRHFDVQLLGGMVLDSNRIAEMRTGEGKTLTATLPAYLNALTGKGVHVITVNDYLARRDAENNRPLFEFLGLTVGINVAGIGQQEKKAAYNADITYGTNNEFGFDYLRDNMAFSPQDRVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYTKINTLIPNLIRQDKEDSEEYVGEGDYSIDEKAKQVHFTERGQEKVENLLIERGMLAEGDSLYSAANISLLHHVNAALRAHTLFERDVDYIVQDGEVIIVDEHTGRTMPGRRWSEGLHQAVEAKEGVHIQNENQTLASITFQNYFRQYEKLAGMTGTADTEAFEFQHIYGLDTVVVPTNRPMVRKDMADLVYLTANEKYQAIIKDIKDCRERGQPVLVGTVSIEQSELLARLMVQEKIPHQVLNAKFHEKEAEIVAQAGRTGAVTIATNMAGRGTDIVLGGNWNMEIDALDNPTPEQKAKIKADWQVRHDAVVAAGGLHILGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDSLMRIFASDRVSGMMKKLGMEEGEAIEHPWVSRAIENAQRKVEARNFDIRKQLLEFDDVANDQRQVVYAQRNELMDAESIEDTIKNIQDDVIGAVIDQYIPPQSVEELWDVPGLEQRLNQEFMLKLPIQEWLDKEDDLHEESLRERIITSWSDAYKAKEEMVGASVLRQFEKAVMLQTLDGLWKEHLAAMDHLRQGIHLRGYAQKNPKQEYKRESFELFQQLLNTLKHDVISVLSKVQVQAQSDVEEMEARRREEDAKIQRDYQHAAAEALVGGGDEDDESIAAHTPMIRDGDKVGRNDPCPCGSGRKYKQCHGKLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: MED7_PICST
Sequence: MSTANGDLISSLYPPPPVYVKFFTTENLNKLQEWQRQQNDEEIETKQEEADDKDEKDNEKQNETQDTVPPGELRFLVPPQPPSGTHYRGYGNIWSFEDKLPSLKSANWEQLYKDDDESITSETKIKELHKLMDSLLLNFLELIGLASIDPSQYESKIKDISLILININHLLNTYRPHQSRESLIMLLRKQIDAKRASINQVEKVCSEVKQKLLKLTNIQDVYKKDSIVLPDNSDNSPMAENAESIKDEIIKKLLSEH
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 7, Mediator complex subunit 7.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 7 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DNAA_BIFLS
Sequence: MVNASGDPVIEAAHIWSDTLTVLKHSASLSPREKGWLEGVVPEGVFGSTIVLCVDNNDTLQAIQGDLNDSLLQALRTVTGENMFPAFKVVPKTEPEPLSAAKPAQPYPSEISPTVAEFGKESYGAKPVAAPREPMPATESQFPVGQQKMNRDPETHLNKNFTFDSFVPGDSNRFARTVALAVAEGSGQDFNPLCIYGGSGLGKTHLLNAIGNYALVKDPGLKVRYVTSEEFTNEFIDALQNPNQSQGQIAEFNRRYRQVDVLLIDDIQFLGGKEATLDQFFHTFNALHQANKRIVIASDVAPKNLKGFEARLISRFESGLTVDVKPPDLETRIAILRMIASMNGSKIPSDVLDLIAERFTENIRELEGALTRVTAVASLSNQPVTRALAEQTLQDFFTTDVEIKPTDIISQVAKYFHLTFEDLVGKSRTKNVAVPRQIAMYLAREMTSMSLMDIGQVFGGRDHTTVMHACTRISDRMQQKQEIYNYVMELTVRLKQSNTN
What is the function of this protein?
Plays an important role in the initiation and regulation of chromosomal replication.  Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'.  DnaA binds to ATP and to acidic phospholipids.
What are the official names of this protein?
Chromosomal replication initiator protein DnaA.
What is the protein family that this protein belongs to?
Belongs to the DnaA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF224_IIV6
Sequence: MKTKNRLLNSDIDFVNESIPYSRSDFNNMLTKLSSNDYYQLMVNTYIGTYGSAKFFGESTKTLPENFNWKTITEFDPPSIVSKKKLISEPENQYLCGNCWAMSTVQTIGDRFVVAGLVNWVPDLSTTFAMLYYPQGQCDGGNSAKLMRQIHTGIGLASKHCIDYSWCSRNIECKTDNSLGHFVSENKSYLLPSKKGCYYNSKHYIYKIDSRPKIISGYGTLNTDNEVLNNQILLKQEILANGPAVGGFLVFENFTSAFTKVNGGVYLENVSNYGSGKPVEFNPHINKYSGNHVVSILGWGVAKGIKISNTQFSDVPYWFCRNTWGKNWGDKGYFKIAMYPFNKKSQFLKLVSIVDHEGHTRRNSGVVICNVSETPILQSLPVIPSTEIPKSLDNSTNFYSQDENYEIKNNSQNEKGFPKGNRRRTTSSDTQIVFIFFLSVVILFIFIIL
What is the function of this protein?
Probable cysteine protease.
What are the official names of this protein?
Probable cysteine proteinase 224L.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: DCD_SHEPC
Sequence: MRLTDIEIEQALDNGTIVIEPRPSIDAISGVSVDVRLGGQFRVFKDHTAPFIDLSGPSGEMQAALDRVMSEIIEIPDGEAFFLHPGELALAVTYESVTLPADIVGWLDGRSSLARLGLMVHVTAHRIDPGWQGKIVLEFYNSGKLPLALRPRMTIGALNFERLSGPVARPYNTRKNAKYKDQQEAVASRISQD
What is the function of this protein?
Catalyzes the deamination of dCTP to dUTP.
What are the official names of this protein?
dCTP deaminase, Deoxycytidine triphosphate deaminase.
What is the protein family that this protein belongs to?
Belongs to the dCTP deaminase family.
Protein: RIMK_MARSD
Sequence: MKIGILSRKRELYSTNSLVEACNARGHEVRVINPLRCYMNITSHNPSILYKGEKLEGFDAIIPRIGASITFYGCAVVRQFEMMGVYCVNESVAITRSRDKLRSLQLLARKGIGLPVTAFAHSTQYTEDLIDIVGGAPLVIKLLEGTQGKGVVLAETRNTAASIIEAFKGLEANILVQEFISEASGSDIRCLVVGGKVIASMKRQGREGDFRSNLHQGGSATQVRITPEERSTAVRSAKIMGLGFCGVDILRSNHGPVVMEVNSSPGLEGIEKTTDIDVAGQLIDYIEKNAQPGKTKTKGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: DPOL_ADEB3
Sequence: MCVYKTYKGKLKITSIPARADRPRLPFPLNFLIHKRKLYLIDTIAEVQRCADCGSYFKQTHTCSTRRRDFYFHHINTQSSDWWEEIKFFPLGAHPDTRRLFVVYDVETYTWHGSFGKQLMPFMLVFTLFGDAQLCEQAVNIAKKQKWSSWPKQANTFYYLNPQRNKVGSLFKQYRDALQEAASTLLWRQFLADNPCLENLCLKLGYVHASDIPFEELCTLELKGQPTFLEVYVVGHNINGFDEIVLAAQVINNKQGIPAAFKVSRNFMPRCGKILFNDLTFALPNPTHAARKDFKDWEEGTPTSADYKFQFVKFMVRDTFALTHTSLRNAAAAYALPVEKGCCPYKAVNEFYMLGTYRTDADSFPQRDYWSSDEEYLLNKSLWLQENSGAYDIVQRTLDYCAMDVLVTAELVKKLQASYLDFVHTSVGLPHCNFNVLQRPTISSNSHAIFRQVVYRSQRPNRSSLGNFLLAPSNEMYDYVRESIRGGRCYPTYIGVLTEAIYVYDICGMYASALTHPFPAGKPLNPFDRALAIKNWQDRLTQLHRPIDYFDRTLLPAIFTIDADPPPEAFLDVIPPFCSRKGGRLCWTNETLRGEVVTCLDAITLHNRGWRVQILNDPRTTVFPQWECLARDYVQLNIAAKERADKEKNQTLRSIAKLLSNALYGSFATKLDNRVTVFSDQMEDKYVRGISDGTYDIKSTAFVETDNLSSSVMAELKITYSPVKQQTDATRKHRQCTPTSNSSSDEDAPFYTLGDPQNHHVTYTYKPITFLEADDSALCLHTLQKKSSLIFNNRYPSHIASFVLAWTRAFVSEWADILYLEDRGTPLEDRILKFVYGDTDSMFLTQRGKELMDTRGKHRLKGNNRPLVFDPTNPQLTWLVECETQCPRCHGDAHSQESVFLAPKLYALKNIYCPSCRAESSGKLRAKGHATSQLSYDLLVTCYYSTEQLGDEKFGTSRLSLRRSLVSRQTHQQPFTVTETTLARTLRPWKDRTLRAIDRHRLAPYSNSHPNPRNKELCWMEMY
What is the function of this protein?
Eukaryotic-type DNA polymerase involved in viral genomic replication.  DNA synthesis is protein primed, and acts in a strand displacement replication.  Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication.  The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.
What are the official names of this protein?
DNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: SEC62_DEBHA
Sequence: MAEVPITTSNQRSQVAINIANYLKDNKILKQRTGLLNNSEDVEFFRYKRLARALLSDDYKTKQANHKNGLIPIADEQEAAKVFITLIQSQFVIPVEKLHYNEIKQANKSWKPNKTKPTLKQSTKANIEPNAYFVWTYNKPNPFILLYSILLLVGIFTIILFPLWPNFMKIGVWYLSMGLLGLLGLFFLIAIIRLIIYIITLLVLPRAFWLYPNLFEDCGVLESFQPLYGWDEPKKSKKGKSSKSASKPETESSGAATGVKPAENAPTKRKVVLEEVDE
What is the function of this protein?
Required for preprotein translocation.
What are the official names of this protein?
Translocation protein SEC62.
What is the protein family that this protein belongs to?
Belongs to the SEC62 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CYB_PROCS
Sequence: MTNIRKIHPLFKILNHSLIDLPTPSNISAWWNFGSLLGLCLAIQIFTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYLHANGASMFFICLYLHVGRGIYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALATTHLLFLHETGSNNPSGIPSDSDKIPFHPYYTIKDTLGFLMLILLLLLLTLFTPDLLGDPDNYSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALIMSILILAIMPFLHTSKQRSMMFRPISQIMFWTLVADLMVLTWIGGQPVEYPFTIIGQVASILYFTIILIFMPLASLIENKILKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AEP2_YEAS1
Sequence: MWINRLVKHPSYSVLRFYTKRLCTVSVKSLREFGVLPNSTICHSVYPRRTYVMGRAVINDILIKKSYSTHTVCAIDRSKDENNGSAYDKFEAKGIPIDVHTLKRIISSSGMDESEFSKSISYLFAKTVDPEPKDVLSLEDLSFLLNKLYTQRFQIRRICRDINAKYSEFWFKLFSLYAEKVDAKRNQVNLRNTKLDACEIFDANLMIKNFIELGQLGKAQKILSFILDRNPDILLSPKNADISTIVHFLQLRCGALAPYWKIPDNSEQKQGFLRKMVRLGAKNTSIRLSSTYKAMDHQTLLKIADLALQEKKLLNSEDLLSTLIQSFGHLGQTQILERCIEHIWQISPQEFPSHVVIKHRGCYPSSKILVSILVSFYFNDHDLHRGLSILDSFIKHYPDVKLDALFWRRLFQLSHFAWTPANDKKATSVVRCWHLMKQWYASKRLRPSVDYETLRQLYDIMKKTGNFPLGIDVLRSFKPGIERTRAENAGKVNNIIIKYQKCIIKELVNRGRFSAVREFIDNYGFDRKMTKDLNIFCANRMFLRSKKMKNKIENKKEREKVRLDSFDDDEDDGMIIGSLW
What is the function of this protein?
Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.
What are the official names of this protein?
ATPase expression protein 2, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the AEP2 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PGK_TOLAT
Sequence: MSVIKMTDLDLAGKRVLVRADLNVPVKDGKVTSDARIVATLPTIKLALEKGAKLMITSHLGRPTEGEYNEEFSLLPVVNYLKDKLSCPVRLAKDYLDGVEVAAGELVVLENCRFNKGEKKNTEELAKKYAALCDVFVMDAFGTAHRAEGSTYGVAQFAPVACAGPLLAGELDALGKAMLKPERPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLCEHDLIDTAKKLAAETNIPVTTDVVVGKEFSESTPATIKSVSEVTDDDMIFDIGPDSAKALADIIMNAKTILWNGPVGVFEFDQFAKGTEIIAKAIAESPAFSIAGGGDTLAAIDKFGIADKVSYISTGGGAFLEFVEGKVLPAVAILEERAKA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BBS1_HUMAN
Sequence: MAAASSSDSDACGAESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDLGPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986).  Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity).
What are the official names of this protein?
Bardet-Biedl syndrome 1 protein, BBS2-like protein 2.
What are the subcellular locations of this protein?
Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Protein: URE11_PSYCK
Sequence: MKISRDAYANMYGPTVGDRIRLGDTELWIEIEKDHTHYGEEVVFGGGKVIRDGMGQSQLCSDSVMDTVITNVIIIDWWGIVKADVGLKDGRIVAIGKAGNPDTQPDVDIIIGAGTEIIAGENQILTAGAVDTHVHYICPQQVDEALMSGLTTMIGGGTGPATGSVATTNTPGPWHIGKMMQAVDDLPINIGFLGKGSASTPAALEEQVKAGVMSLKVHEDWAATPATIGNALDVADRYDIQVALHADSLNESGFVKDTLEAFKDRCIHSYHTEGAGGGHAPDIIVACGQPNVLPSSTNPTRPYTINTVDEHLDMLMECHHLDPNIPEDVAFADSRIRRETIAAEDILHDLGAISMISSDSQAMGRIGEVVCRTWQTAHKMRLQRGLLPEDQERGTDNFRVKRYIAKYTINPAITHGVSHEVGSVEIGKMADLVLWRPKFFGVKPSIILKGGMIAGAAMGDPNAAISTPQPVHYRRMFGALGRAVSATRVTFVSQAAMDTGLEEKLGLRSRLVACKNVRSMRKKDMKLNDYCPNITVDPETYEVRVDGVLLTCEPLSELPLAQLYHLF
What are the official names of this protein?
Urease subunit alpha 1, Urea amidohydrolase subunit alpha 1.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEC_PENST
Sequence: DASNAQKQHDVNFLL
What is the function of this protein?
Sialic acid-specific lectin.  Has hemagglutinating activity towards erythrocytes from several species, with high activity towards, rabbit, mouse and guinea pig erythrocytes, and low activity towards human erythrocytes.  Hemagglutinating activity is blocked by treatment of erythrocytes with V. cholerae sialidase.
What are the official names of this protein?
Lectin 80 kDa subunit, LsL.
What is the protein family that this protein belongs to?
Belongs to the tyrosinase family. Hemocyanin subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: GFPPS_MYCTU
Sequence: MAGAITDQLRRYLHGRRRAAAHMGSDYDGLIADLEDFVLGGGKRLRPLFAYWGWHAVASREPDPDVLLLFSALELLHAWALVHDDLIDRSATRRGRPTAQLRYAALHRDRDWRGSPDQFGMSAAILLGDLAQVWADDIVSKVCQSALAPDAQRRVHRVWADIRNEVLGGQYLDIVAEASAAESIESAMNVATLKTACYTVSRPLQLGTAAAADRSDVAAIFEHFGADLGVAFQLRDDVLGVFGDPAVTGKPSGDDLKSGKRTVLVAEAVELADRSDPLAAKLLRTSIGTRLTDAQVRELRTVIEAVGARAAAESRIAALTQRALATLASAPINATAKAGLSELAMMAANRSA
What is the function of this protein?
Catalyzes the sequential condensations of isopentenyl pyrophosphate (IPP) with dimethylallyl diphosphate (DMAPP) to yield geranyl diphosphate (GPP) and with GPP to yield (2E,6E)-farnesyl diphosphate (E,E-FPP).
What are the official names of this protein?
(2E,6E)-farnesyl diphosphate synthase, E,E-FPP synthase, FPP synthase, Dimethylallyltranstransferase, Geranyl diphosphate synthase, GPP synthase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: PATR_MYCMM
Sequence: MTARLRPVLAGLPVYVPGKTVPGAIKLASNETVFGPLPSVRAAIEHATQSINRYPDNGCLAVKAALARHVSSLSAADFGPEHIAVGCGSVSLCQQLVQITASVGDEVIFGWRSFELYPPQVQVAGATAIQVPLTNHTFDLEAMLAAVTERTRLIIVCNPNNPTSTVVQPEALAEFVRSVPPHILVAIDEAYVEYLRDGTVPDSPHLVRTHSNVVVLRTFSKAYGLAGLRVGYAVGQPDVIAALDKVYVPFTVSSLAQAAAIASVQAADELLARTDAVVAERGRVSAELRAAGFTVPPSQANFVWLPLEDRTTDFVTQAAKAHIVVRPYGADGVRVTIAAPEENDALLRFARCWITHRDGAR
What is the function of this protein?
May catalyze the transamination reaction in phenylalanine biosynthesis.
What are the official names of this protein?
Putative phenylalanine aminotransferase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Protein: ACES_DROME
Sequence: MAISCRQSRVLPMSLPLPLTIPLPLVLVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSASISPRLQLLGIAALIYICAALRTKRVF
What is the function of this protein?
Rapidly hydrolyzes choline released into the synapse.  It can hydrolyze butyrylthiocholine.
What are the official names of this protein?
Acetylcholinesterase, AChE.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Synapse. Cell membrane; Lipid-anchor, GPI-anchor. Note=Attached to the membrane of the neuronal cholinergic synapses by a GPI-anchor.
Protein: TYW3_ARCFU
Sequence: MMWEQFKKEKLRGYLEAKNQRKVDFDIVELLDLINSFDDFVTLSSCSGRIAVVDLEKPGDKASSLFLGKWHEGVEVSEVAEAALRSRKVAWLIQYPPIIHVACRNIGAAKLLMNAANTAGFRRSGVISLSNYVVEIASLERIELPVAEKGLMLVDDAYLSYVVRWANEKLLKGKEKLGRLQEALESLQRENAYCSD
What is the function of this protein?
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway.  Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
What are the official names of this protein?
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase, tRNA wyosine derivatives biosynthesis protein Taw3.
What is the protein family that this protein belongs to?
Belongs to the TYW3 family.
Protein: DAM1_YARLI
Sequence: MQRPTTPLRRSNSRQSDHEEHYPIVESVLDMAIGEQMAELADGMSALDRNLKDLQVIHTNLNNFNESFSTLIYGLQMNAWCAEFHNGPRSCDFARRKEVEEMEERARRAQMQAERDRMAMQQIQETPTRLPSEPSDGDVTYMRNDNSFIIQPPSSYQSQLPSRIPQSSRASRIRPPNSLRPPRGRGLYLRGGSRGVTGGRGSYTGVGRGSGRPASEGTTRRWL
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit DAM1, Outer kinetochore protein DAM1.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAM1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.
Protein: ACKA_SHEFN
Sequence: MSDKLVLVLNCGSSSLKFAIIDAQSGDDKVSGLAECFGLEDSRIKWKFDGGKNEAKLGAFTAHREAVEFIVNNILAEHPELAAQIKAVGHRIVHGGEKFTRSVIVTPEVIQGIEDCASLAPLHNPAHLIGIRAALASFPALPQVAVFDTAFHQTMPEKAYIYALPYKLYREHSIRRYGMHGTSNIYICREAAKVLGKETKDTNIICAHLGNGASVTAIKDGKSVDTSMGLTPLEGLVMGTRCGDLDPSIIFHLVKQLGYTLDEVNNLLNKQSGLLGISELTNDCRGIEEGYQDGHKGATLALDIFCYRLAKYIASYTVPLGRLDAIIFTGGIGENSDLIREKVLNLLAIFNFKVDDNLNKAARFGQQGIITQVGSPIAMVIPTNEEWVIAEDAIKLITAK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBIE_METJA
Sequence: MIYIVGIGPGDREYLTLKAIKIVENADLVVGSKRALELFNIDEDKKITLTKNLIGELKELIKNENIKNKKIAILSTGDPCFSGLLKTLLKIGAKKEDIEAISGISSIQIAAAKLKISWEDYYIITLHGKEENRKKLLNLIKNHEKVIFLPNNLKEDAKFLINNGINPDTKIWVLENLTYENEKISLKSLKEIANGDFSYLTVCVYEGDEEI
What is the function of this protein?
Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8.
What are the official names of this protein?
Probable cobalt-precorrin-7 C(5)-methyltransferase, Cobalt-precorrin-6Y C(5)-methyltransferase, Cobalt-precorrin-6 methyltransferase, Cobalt-precorrin-6Y methylase.
What is the protein family that this protein belongs to?
Belongs to the precorrin methyltransferase family.
Protein: LFTR_PSYIN
Sequence: MTLYIPELPINNTIFPDTSLALSDPDGLLAMGGDLSPQRIIKAYQQGIFPWFSDGQPILWWSPSQRAIIQPNLVHISSSMKKIISKNNFSLSINHAFHDVIDACAAPRGNQNETWITFDMIAAYQKLHQQGIAHSIEVWRDNKLVGGLYGVCIGSVFCGESMFSKEDNTSKIAFIALCQHFDKFKGQLIDCQILTKHLQSFGVQNESRDNFINYLNQYKNININKKCWDKQTIFIKNR
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSIH_PSICU
Sequence: MIAVLFSFVIAGCIYYIVSRRVRRSRLPPGPPGIPIPFIGNMFDMPEESPWLTFLQWGRDYNTDILYVDAGGTEMVILNTLETITDLLEKRGSIYSGRLESTMVNELMGWEFDLGFITYGDRWREERRMFAKEFSEKGIKQFRHAQVKAAHQLVQQLTKTPDRWAQHIRHQIAAMSLDIGYGIDLAEDDPWLEATHLANEGLAIASVPGKFWVDSFPSLKYLPAWFPGAVFKRKAKVWREAADHMVDMPYETMRKLAPQGLTRPSYASARLQAMDLNGDLEHQEHVIKNTAAEVNVGGGDTTVSAMSAFILAMVKYPEVQRKVQAELDALTNNGQIPDYDEEDDSLPYLTACIKELFRWNQIAPLAIPHKLMKDDVYRGYLIPKNTLVFANTWAVLNDPEVYPDPSVFRPERYLGPDGKPDNTVRDPRKAAFGYGRRNCPGIHLAQSTVWIAGATLLSAFNIERPVDQNGKPIDIPADFTTGFFRHPVPFQCRFVPRTEQVSQSVSGP
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product (PubMed:28763571).  The first step in the pathway is the decarboxylation of L-tryptophan to tryptamine by the decarboxylase psiD (PubMed:28763571).  4-hydroxy-L-tryptophan is accepted as substrate by psiD as well (PubMed:28763571).  The cytochrome P450 monooxygenase psiH then converts tryptamine to 4-hydroxytryptamine (PubMed:28763571).  The kinase psiK catalyzes the 4-O-phosphorylation step by converting 4-hydroxytryptamine into norbaeocystin (PubMed:28763571).  The methyltransferase psiM then catalyzes iterative methyl transfer to the amino group of norbaeocystin to yield psilocybin via a monomethylated intermediate, baeocystin (PubMed:28763571).
What are the official names of this protein?
Tryptamine 4-monooxygenase, Cytochrome P450 monooxygenase psiH, Psilocybin biosynthesis hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.