Protein: STHA_PHANO
Sequence: MSHNKPVNEPIVIIGSGCRFAGGANSPSKLWDLLRNPKDLRSDVTSRFNSQGYYHKDGTHHGHMNVLQSYLIGEDTRLFDAEFFGVNPVEAKAMDPQQRLLLEVVYEAIESAGLSMERMRGSDTAVFAGLMCGDYEAMMLRDLDQAPTHFAIGTSRAILSNRVSYFFDWHGPSITIDTACSSSLVAVHHAVQALRSGDSHAAIACGSNLILGPEMYVIESKLKMLSPDGLSRMWDKDANGYARGEGVTAVVLKTLSQALADNDRIEAVIRETGVNQDGATPGITMPSASAQRALIHSVYRKAGLDPESPNDRPQYIESHGTGTPAGGSIKTVLGHTEGSAGIAALLKVTKAIQNATVPPNLWFQQLNHKLEPFYGNIQIPTQPVTWPATEKRRRKRASINNFGFGGTNAHAIVEGYEPKEEIPPPSFHHVDATVSTPFVFSAASKESLRANLAAYALHLDAHPQISTRDLAYTLRERRSVLPFRIAFPESNTKDLKLSIAARLSESDGEGLGVRTWAANNGGSSKLLGIFTGQGAQYARMGTELLAQTNMARKTLEELEGYLAELPEEDRPSWSLQSELLADPSVSRVGEAAISQPLCTAVQIILVKLLCSAKVRFDTVIGHSSGEIAAAYAAGYLSARDALLVAYYRGLHCKLAASPNGNVKGAMLAAGTSLEDATELCEDEEFSGRINVAASNSSSSVTISGDEDAIDELATVFDDEKKFNRRLKVDTAYHSKHMLPCFEPYVASLRRVGITVLPGNDQCTWISSVHEGRAINPATDELADVYWAQNMTKPVLFSQAVQAAVAPVRGGEPFAAALEVGPHAALAGPAKQTIQEVAQKEIPYHGSLVRGENATKAFATCLGFLWERLDAASLDLGSCEAALSSSGGVQQYTVLADLPTYQWKHETVYWAESRRSRRMRLREGPFHQLLGNVSPDSAPHILRWKNVLKPKEMTWLEGHQVQNQVVLPAATYICTAIEAARSLAQGKNIQLIELSNFCIHNAITFDQNDVGVEVLVELSRINVKENHVNATFTYTAGLGDETNDLALAANGELNILLVDDDPSLALFPERQEPPPHMIPVQPSRLYDFMKGLEYDFSGPFQSLAKLERKLGTATCLAKKARKSVPDADDLLVHPVDLDAAFQSVMLAYSYPGDDQLRLLHLPTSIERLRVNPAALSSQKYVENDTTILDSTCTTADRAEPGNGFSGSVNMYAAGFDHAAIQVEQVKFKPVGSDAKDDRNVFYKMHWVPSKPDGLLAAASVPITERDRKLMFVLSRIAAYYLRKFDEMIAEDDPARLESPLCHYMRYARHMMGLLRAGEHKWAYKEWLQDTEQDVFDDIASKGFQDNSDVRIMLLVGSTMPRVFRRETTMLEHFRTSGLLDEYYSNGFGTKQCTLWVAGVLKQLADCNPHLNLLEIGAGTGSATKTILKSVGHDFASYTFTDISSSFFENAAETFSDYGSRMVFKVCNAENDPVEQGFEAGTYDVVIAFMVIHACAKLDEAVANLRKLLKPGGLLVLGEGASDGAMQAGAGFIFGTLPGWWRGVDEGRTLSPLVSASEWQVILRDAGFSGIDTMSPPELFDAFGITLFVSTAVDERIEFVRNPRAKASRAVYNKVVVIGGITSTIAKLAEEIQTVLTPLAIQVLLCTSLEDLQENVLDDETVIISLVDLEAPVFKDITSERWYKFRLLFETKREILWLTSGRLEDEPYSNMTVGFGRSAMHEEETLRVQYLDVADVSQLNAVMVMQYLLRFTSSELDKSDILYTKEPEVIIDANGRELVPRLFTIQAANNRLNSVTRPIYEDVDTSQSVVELRYAKEEPSFRKLSRYEVSAKLEPSHDTTIKLRVAYSVISALRCPAGYQYLIMGFDESGARRVALVNSLTSVLCVPLKSTILCELYDMSEPSYLTLLAAEIIAMTIVDPLFTGQKLAILNASKLIIQAIASYATAKGVETTFIVDAGGEFVPKDVAVQSHLPLYPSRSDMSFILPTNLACFVSFSALNKADSEDAMKSLLPFYCQKMNTSTLFSTHGVDTGALGATAQHVLSRAISSRKGRVIDWTPPSTSLSVRITRFEMTQLFKADKTYWLVGLSGALGISLCDWMIERGVKYLVLTSRNPKIDERWIENHEKHGVMIKILLCDVTDEAAIKDVHQTIVRTLPPIAGLLNGAMVLRDVSVRNMEYAQVTDVIRPKVLGSIHLDRIFHDIDLDFFVLLSSINCVIGNVGQANYAAANMGMIGVAGHRRKRGLRSSVVNVGAIIGVGYITQSDRQLDVTVAKTAMMHLSEQDFHQIFAECMEAGHLDNDSGPEISTGLLEITPDTIDIPPWYSDPKFKRFQVHQAAAGAGKAEVANSASTQELLLACRSQADITKVVQQAYCAQLRRILQVSTADEDLMMMRGVDLGFDSLLSVDVRSWFLKNFRVSIPVLKIMANDVRMSTLVDLAAESIPAELIPHVQQQQQQAGRQDASSNTSSDDETASTLPTSPESASPGTSTPVPEKDISPVDTFNSVDWYFETTPPSISTFSELTSAPAPRSDPKVVVLTGCSGLLGHHLLSTLIAQPSIRKIICLAVRSLPSRLSSGELPLPGDKIEYHAGDLTAPQLGLSTSTWISIFKQADAVIHNGSDTSHLKYYSALKLANVDSTKQLVSTCLQRMIPFHYVSSAGVALFAERDAFPPVSCTTTGKTPPADGSHGYMCGKWVCEKMLERVYEQYHLPIVIQRPSTIIRSGEDAAVERAGFDWVNSLLHFAHQTQTVPRVDHNAGAFDLVSVDTCCSDVARKLTRATKERITYVNNVGDVVIPMASMADVGLDRIGKRYNVLTMDEWTKTVVEAGMHPAVAALIETFDEPGVEKYPMLLRE
What is the function of this protein?
Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the phytotoxin stemphyloxin II (PubMed:31553484).  The first step of the pathway is the synthesis of dehydroprobetaenone I by the polyketide synthase sthA and the enoyl reductase sthE via condensation of one acetyl-CoA starter unit with 7 malonyl-CoA units and 5 methylations (PubMed:31553484).  The C-terminal reductase (R) domain of sthA catalyzes the reductive release of the polyketide chain (PubMed:31553484).  Because sthA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase sthE (PubMed:31553484).  The short-chain dehydrogenase/reductase sthC then catalyzes reduction of dehydroprobetaenone I to probetaenone I (PubMed:31553484).  The cytochrome P450 monooxygenase sthF catalyzes successive epoxidation, oxidation (resulting from epoxide opening) and hydroxylation to install a tertiary alcohol in the decaline ring to yield betaenone C from dehydroprobetaenone I and betaenone B from probetaenone I (PubMed:31553484).  The FAD-linked oxidoreductase sthB is responsible for the conversion of betaenone C to betaenone A via an intramolecular aldol reaction between C-1 and C-17 to form the bridged tricyclic system in betaenone A (PubMed:31553484).  Finally, the cytochrome P450 monooxygenase sthD catalyzes the hydroxylation of C-15 to afford the final metabolite stemphyloxin II (PubMed:31553484).
What are the official names of this protein?
Highly reducing polyketide synthase sthA, HS-PKS sthA, Stemphyloxin II biosynthesis cluster protein A.