PharMolix/UniProtQA huggingface dataset:
Protein: NDUA7_MOUSE
Sequence: MASATRVIQKLRNWASGQDLQAKLQLRYQEIAKRTQPPPKLPVGPSHKLSNNYYCTRDGRREVVPPSIIMSSQKALVSGKAAESSAMAATEKKAVTPAPPMKRWELSKDQPYL
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, Complex I-B14.5a, CI-B14.5a, NADH-ubiquinone oxidoreductase subunit B14.5a.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA7 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: BIOB_MYCPA
Sequence: MTQAATRPTAEIGNEDILAVARRQVLEGGQGLSRDQVLQVLRLPDDRLDDLLALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSGLFASPVRSARLDIPSLVEAAKQTAKSGATEFCIVAAVRGPDERLLAQVAAGIEAVRNEVEINIACSLGMLTAEQVEQLAEMGVHRYNHNLETARSFFPNVVTTHTWEERWDTLSMVRDAGMEVCCGGILGMGETLEQRAEFAAELAELGPDEVPLNFLNPRPGTPFGDLEVMPATEALKSVAAFRLALPRTMLRFAGGREITLGDLGAKKGILGGINAVIVGNYLTTLGRPAESDLELLDDLQMPLKGLNASL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: CRAC1_HUMAN
Sequence: MAPSADPGMSRMLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLPPDYDSNPTQLNYGVAVTDVDHDGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSSPYYALRDRQGNAIGVTACDIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWEDILSDEVNVARGVASLFAGRSVACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDLSRGILALRDVAAEAGVSKYTGGRGVSVGPILSSSASDIFCDNENGPNFLFHNRGDGTFVDAAASAGVDDPHQHGRGVALADFNRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDIASPKFSMPSPVRTVITADFDNDQELEIFFNNIAYRSSSANRLFRVIRREHGDPLIEELNPGDALEPEGRGTGGVVTDFDGDGMLDLILSHGESMAQPLSVFRGNQGFNNNWLRVVPRTRFGAFARGAKVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGKDEASSVEVTWPDGKMVSRNVASGEMNSVLEILYPRDEDTLQDPAPLECGQGFSQQENGHCMDTNECIQFPFVCPRDKPVCVNTYGSYRCRTNKKCSRGYEPNEDGTACVGTLGQSPGPRPTTPTAAAATAAAAAAAGAATAAPVLVDGDLNLGSVVKESCEPSC
What are the official names of this protein?
Cartilage acidic protein 1, 68 kDa chondrocyte-expressed protein, CEP-68, ASPIC.
Protein: PRMA_ACET2
Sequence: MKWIEIKIKTTEEACDAISYMLTSIGAGGVAIEDPNEIRRETQKSNSIDYVDDEFLNSLGEDVVVKAYFPGETNVPELVSLIKEKLAFIGTFLNVGEGYCGYAEMDEEDWSNSWKKYYKPLHLTDRLIVKPSWENYDNKDGEIIIEMNPGMAFGTGTHETTKMCAVLLDKYVKDGCRVIDVGCGTGILSIIASKLGAAEVTAVDIDEVAVKVAKENLELNKVDNVRVFKGVLDDIEKEKRDIVVANIIANVIMDISSRVPYYLKKDGLFIASGIIKERKQEVLDECLRKGFECVEIIEMGEWVAIVLRCLDSL
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_ENTFA
Sequence: MAIKKYKPTTNGRRNMTSSDFAEITTSTPEKSLLQPLKNNAGRNNNGRITVRHQGGGHKRQYRVIDFKRNKDNVAAVVKTIEYDPNRSANIALVHYEDGVKAYILAPKGLEVGMRLVSGPEADIKVGNALPLENIPVGTVIHNIEMKPGKGGQLIRSAGTSAQVLGKEGKYVLIRLNSGEVRMILATCRATIGSVGNEQHELINIGKAGRSRWMRKRPTVRGSVMNPNDHPHGGGEGKTPIGRKAPVSPWGQPAIGYKTRNKKAKSDKLIVRRRTK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: HETQ1_PODAN
Sequence: MPTKTSQHAFAGSERWVVPRYSSKPGTLIRLGSVLTDPEDLESSLNLDSIPPIPPHLLRDATPEVRMSVQTELSKSDSTLAKAAPALEGILTLGGGVEASRSQGVSSSLNISGTVKATVFRADKSYMDVLLKDKNVISYAKRGLGKPMFVVVGVATAGRVEMKETRHVTRKAGVSGKVGVEVIGEGEVGLERERSDKSCNEVRGEGGLDFAYRVREFGYSRVRGTVKDKGDWTGKVLFAGGKGPVVEKGGEVVPVFKEFKEGEVKLRATGSFDVAAKA
What is the function of this protein?
Pore-forming protein that causes membrane permeabilization and cell death (PubMed:35135876).  Released upon cleavage and maturation by het-Q2 and binds to membrane inner leaflet lipids (PubMed:35135876).  Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering cell death (By similarity).
What are the official names of this protein?
Gasdermin-like protein het-Q1, Heterokaryon incompatibility protein Q1.
What is the protein family that this protein belongs to?
Belongs to the gasdermin family.
What are the subcellular locations of this protein?
[Gasdermin-like protein het-Q1, N-terminal]: Cell membrane; Multi-pass membrane protein.
Protein: RL34_ORITI
Sequence: MKRTYQPSKLVRKRRHGFMERMSSVGGRRVLMRRRMKGRRVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: LPXK_FRAP2
Sequence: MIDNIWYKPQLGILSYILSPIAFIFSKIAHNRKIRLQNNQYKSKIPVIIVGNISVGGTGKTPVVRMFANQYLEQGKKPVIISRGYGAKAEKYPFEVDSKTPASVCGDEPAMLFDALGGKVPIVISPHRVDSVKYIEKNYPDADVIISDDGLQHYKLARTKEVVVVDASRMFGNGLCLPAGPLREPVERLKSVDQIIAIGNLDNQNYSELLNYNSNIVRAKIKATKFVNLVTKQSILIDSFYGKSIDAVAGIGNPDKFFSSLDELGVNIYHEHIFRDHHKYTPKDFEHFDPEQIVIMTYKDAIKCKDFAKSNWWYLDIALEFC
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: LPTE_PECCP
Sequence: MRHRLFTLLLGLAVLITAGCGFHLRGTTQVPAQLQTLVLDSSDPYGPLTRAVREQLRLSDVKIVDDATRQDIPSLRVLGSSETRDTVSIFQDGKTAEYQMVLTLQAQVLMPGEDIYPLSVTVFRTFFDNPLAALAKDAEQDIVRQEMREQAAQQLVRKLLTVNGSQEVKNRQQSTHSTAAATRS
What is the function of this protein?
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.  Required for the proper assembly of LptD.  Binds LPS and may serve as the LPS recognition site at the outer membrane.
What are the official names of this protein?
LPS-assembly lipoprotein LptE.
What is the protein family that this protein belongs to?
Belongs to the LptE lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: Y1454_HAEIN
Sequence: MLDQQLLIGTVFLAGLASFLSPCIFPIIPIYFGILSKGGKKVLNTFLFILGLSLTFVSLGFSFGFLGNILFSNTTRIIAGVIVIILGIHQLGIFKIGLLERTKLVEIKTSGKSTALEAFVLGLTFSLGWTPCIGPILASVLALSGDEGSALYGASMMFVYVLGLATPFVLFSFFSDSLLKRAKGLNKHLDKFKIGGGILIIVMGILLITNNFS
What is the function of this protein?
Could be involved in cytochrome c synthesis.
What are the official names of this protein?
Putative cytochrome c-type biogenesis protein HI_1454.
What is the protein family that this protein belongs to?
Belongs to the DsbD family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HPPK_MYCLE
Sequence: MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSFLNAVVIADGPAYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQTSGATTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDSDAELTVAGRAQRVDRLLAEMEPTEREGVRLTNLTLKLKRSSPARPVSPKSD
What is the function of this protein?
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
What are the official names of this protein?
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK.
What is the protein family that this protein belongs to?
Belongs to the HPPK family.
Protein: OPGD_SALG2
Sequence: MNRRRFIKGSMAMAAVCGSSGIASLFSQAAFAAESDIADGKIVRFDFAGLQSMAQALAKKPWGGAPGPLPDTLANLTPQAYNSIQYDAAHSLWNGVANRQLDIQFFHVGMGFRRRVRMFSVDTTTHLAREIHFRPELFKYNDAGVDTTQLEGQSDLGFAGFRVFKAPELARRDVVSFLGASYFRAVDDTYQYGLSARGLAIDTYTDGQEEFPDFTAFWFDTAKPGDTTFTVYALLDSASVTGAYKFVIHCEKSQVIMDVENHLYARKDIKQLGIAPMTSMFSCGNNERRVCDTIHPQIHDSDRLAMWRGNGEWICRPLNNPQKLQFNAYMDDNPKGFGLLQLDRDFSHYQDVMGWYNKRPSLWVEPRSKWGKGAVSLMEIPTTGETLDNVVCFWQPEKAIKAGDTLAFNYRLYWSAQPPVQSPLARVMATRTGMGGFPEGWAPGEHYPDKWARRFAIDFVGGDLKAAAPKGIEPVITLSSGEAKQIEILYVEPFDGYRIQFDWYPTSDSTAPVDMRMFLRCQGEAISETWLYQYFPPAPDKRRYVDDRIMR
What is the function of this protein?
Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein D.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: LHPL5_RAT
Sequence: MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVSTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALAMFLIIGSIICFSLFFVCNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGNEEV
What is the function of this protein?
In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel.  Regulates transducer channel conductance and is required for fast channel adaptation (By similarity).
What are the official names of this protein?
LHFPL tetraspan subfamily member 5 protein, Lipoma HMGIC fusion partner-like 5 protein, Tetraspan membrane protein of hair cell stereocilia.
What is the protein family that this protein belongs to?
Belongs to the LHFP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Efficient localization to the plasma membrane requires the presence of PCDH15.
Protein: FHL2_HUMAN
Sequence: MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI
What is the function of this protein?
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation.  Negatively regulates the transcriptional repressor E4F1 and may function in cell growth.  Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.  Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008).
What are the official names of this protein?
Four and a half LIM domains protein 2, FHL-2, LIM domain protein DRAL, Skeletal muscle LIM-protein 3, SLIM-3.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line.
Protein: NUOC_BURM9
Sequence: MASKIETLKANLEAALGARAVSLVEAVGELTLVVKASDYLEVAKQLRDDRSLGFEQLIDLCGVDYQTYGDGAYDGPRFAAVLHLLSVANNWRLRVRVFASDDDLPIVPSVVDIWNSANWYEREAFDLYGIVFEGHPDLRRILTDYGFIGHPFRKDFPVSGYVEMRYDPQEKRVVYQPVTIEPREITPRVIREDRYGGLKH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: FETP_YERPE
Sequence: MSRTIFCTFLKKDAERQDFQLYPGEIGKRIYNEISKEAWSQWITKQTMLINEKKLSMMNIEDRKLLEQEMVNFLFEGQDVHIAGYTPPSK
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: TPH1_HUMAN
Sequence: MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
What is the function of this protein?
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
What are the official names of this protein?
Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Protein: OST48_CHICK
Sequence: GPRSLVLLENLNLRDTHSLFFRSLADRGFELTFRTADDAGLSLIKYGEFLYDNLIIFSPSIEDFGGNINVETITAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEERTAVIDHHNYDISDPGQHTLIVADAENLLKAPTIVGKKALNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVVFSGSLDFFSDAFFSSAVQKAAPGSKRYSQTGNYELAVALSRWVFKEEGVLRVGAVSHHRVGELAPPNAYTVTDLVEYSIVIEKLSDGKWIPFDGDDIQLEFVRIDPFVRTFLKRNGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYAGAFSMMVGLFMFSIVFLHMKEKEKSD
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity).  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity (By similarity).  Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, DDOST 48 kDa subunit, Oligosaccharyl transferase 48 kDa subunit, OST 50 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the DDOST 48 kDa subunit family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: DDR48_CANAL
Sequence: MVFGFGKDDDKDKNDRRDNDSYGSSNRRNNDDSYGSSSFGSSNDDDNSYGSSNKRSNDSYGSSNTDSYGSSNRRDNDSYGSSNNDSYGSSKTDSYGSSNRSGNDSYGSSNNDSYGSSNRKGNDSYGSSNTDSYGSSNTDSYGSSNTDSYGSSNKRGNDSYGSSNDDSYGSSNDDSYGSSNRRGNDSYGSSNDDSYGSSNRRGNSDSYGSSDY
What is the function of this protein?
Cell surface protein involved in the ability to sense and respond to changes in the host environment.  Required for stress response and confers partial antifungal drug resistance.  Contributes to the DNA damage response.  Required for the flocculation response stimulated by 3-aminotriazole-induced amino acid starvation.
What are the official names of this protein?
Stress protein DDR48, DNA damage-responsive protein 48, DDRP 48.
What is the protein family that this protein belongs to?
Belongs to the DDR48 family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: Y1600_HAEIN
Sequence: MKLQGAGLGYRRNLAEDFLQLPSNNAIQFIEVAPENWSKMGGMARYQFDQAAERFPLAVHGLSLSLGGQAPLDRELLRNTKALINQYNSSFFSEHLSYCECEGHLYDLLPMPFTEEAVKHVAQRIRDVQDFLGLQISLENTSYYLHSPTSTMNEVEFLNAIAQEADCGIHLDVNNIYVNGVNHGLLDPYIFLDQVDVKRVNYIHIAGHDEEHSAAQVVENSANESFNKVKGAYRHLPELLIDTHGEAVKGTVWDLLEYAYQRLPTIPPTLLERDFNFPPFAELYAEVEHIAQLQQKYAHTEVMSYAA
What are the official names of this protein?
UPF0276 protein HI_1600.
What is the protein family that this protein belongs to?
Belongs to the UPF0276 family.
Protein: LPOA_HISS2
Sequence: MLSILMQGLRLKKCFLPILVMFFLAGCVNLLGSSFTASLKNDANASSDFYIRKIEQTQNQQDLQTYKLLAARVLVTENKIPQAEAYLAELIDLNDEQKLDKSLIEAHISAVKGKNETAEYQLSLIHLTSLSPSQKSRYYEIVSRIAENRHDNISAIKARIQMDNFLSDIQRKQQNNDRTWALLRNTDSEVLNNTDAEGNITLSGWLTLAQLYNDNLNQPAQLIQTLLTWKNYYPTHTAAHLLPTELQGLANFQQTTLTQVGLILPLSGNTRLIGETIKNGFDDAKVNYNVQVHVFDSMKMSIEQIINQAKKQGINTLVGPLLKQNVDVIVNNPYLVQDLNVLALNSTPNARAIEHLCYYGLSPEDEAESAASKMWNDTVRIPLVLVPQNNLGRRTAAAFTLRWQQLLGTDANIKFYNQTADINFALKSGLSESTDGVYIIANNKQLAEIKAVLDNINPTLKLYASSRSNSPNSGPEHRLFLNNLQFSDIPFFKDRESEQYKKIEKMTNNDYSLMHLYAMGYDAWLLINQFNEFRQIPGFTIDGLTGKLSAGPNCNVERDMTWFQYQNGSIYPLNEQDDSIYLINEE
What is the function of this protein?
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
What are the official names of this protein?
Penicillin-binding protein activator LpoA, PBP activator LpoA.
What is the protein family that this protein belongs to?
Belongs to the LpoA family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor; Periplasmic side.
Protein: PYRD_BARQU
Sequence: MSFFRCIGRFALFMLDPEHAHRLAIVGLKSGLNSYRKVVDRRLCLTVAGLEFENFVGLAAGFDKNAEVVEAIFHLGFGFTEIGTVTPKPQVGNPKPRLFRLREDEAIINRMGFNNNGHHIVYSRLCACKKLGIVGINIGANKDTVDKIDDYATGIACFYDIADYFTVNISSPNTPGLRDLQARDSLHLLMNALSQARREQKKKHGFSVPIFLKIAPDLSEKELDDVAEEMKLSDFDGLIVSNTTLSRQGLRDSKLSGEKGGLSGCPLFERSTIVLAKMRQKLGKEIAIIGVGGIKDAQTALEKIKAGADLIQLYSGIVYEGPDLAITILKEILQFMQQDGVDTIKTYRDHRVEYWAKRALPL
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ACY3_HUMAN
Sequence: MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS
What is the function of this protein?
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules.  Also acts on N-acetyl-aromatic amino acids (By similarity).
What are the official names of this protein?
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Acylase III, Aminoacylase-3, ACY-3, Aspartoacylase-2, Hepatitis C virus core-binding protein 1, HCBP1, HCV core-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the AspA/AstE family. Aspartoacylase subfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.
Protein: KCC2A_RAT
Sequence: MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
What is the function of this protein?
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation.  Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654).  Regulates dendritic spine development.  Also regulates the migration of developing neurons.  Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity).  Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity).  In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023).  In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity).  Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity).
What are the official names of this protein?
Calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
What are the subcellular locations of this protein?
Synapse. Postsynaptic density. Cell projection, dendritic spine. Cell projection, dendrite. Note=Postsynaptic lipid rafts.
Protein: MTNB_XYLFT
Sequence: MNATCTPSLPYDASRLRELAHLLIGTISEFAQAGWTPATSSNFSHRLDEHHVAITVSGRDKRCLREEDIMAVDLDGNAVGHPHTPSAETLLHTQLYRRFPEIGCVLHTHSLTQTVASRVYAGAGHISLKDYELLKAFAGHSTHETTLDVPVFCNTQNMNILAAQVDTLLDKQRMWGYLINGHGMYTWGNTLADARRHLEALEFLLHCELDLLKLRGYL
What is the function of this protein?
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
What are the official names of this protein?
Methylthioribulose-1-phosphate dehydratase, MTRu-1-P dehydratase.
What is the protein family that this protein belongs to?
Belongs to the aldolase class II family. MtnB subfamily.
Protein: RL5_MICAN
Sequence: MSQKLKTTYQETIVPKLKEQFGYTNIHQVPKVIKITVNRGLGEASQNAKALESSKAELSTITGQQPVVTRAKKAIAGFKIREGMPVGVMVTLRGDRMYAFLDRLINLALPRIRDFRGISGNSFDGRGNYSLGIREQLIFPEIEYDKIDQIRGMDISIITTAKNDEEGRALLKEMGMPFR
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.