PharMolix/UniProtQA huggingface dataset:
Protein: IRE1_CAEEL
Sequence: MRATFHLFTFIFLLLFSSVICISTPGFRNDHESIGDDEEKTSSTILVSTIDGRLRALDSETGEIKWTLQEEPVLRSPSAVKQGFTFLPNPLDGSLYVLKNSSLKKLPFNIPQLVHASPCKGNDGILYAGSKKDVWFGIDPKTGLKVETLSSASADRICPANQKQTIFLGRTEYRVSMFDEKNRGKTWNATFNDYSAHLLPEVNTWPFKHYASSSHGYILTFDRETGEMRWEQDLKQPVVALYLLRDDGLHKLPFEVMGKETMENVAKNIFTVDQWPTVLGVNAADPQTTSLTNQFFPALFVGESSFGLYAIEALVDHQTITYSPKLLGPPLLEGPAPIALTEMEKEEYLPPRRPIIRNIPPSITHKTSDGEYLLLGYHDRPMMTMATIIPTRYPVPGPHKAIGSTIERPPPQLLGPVEPQKHEDTSFILLLLNNHPIPFYATLVTMFALLLTVIWQCGRQWDQQKSTSRMDSFEIVNNPGESRSAQTSKQSNRGSFGWANRKIEIPEGWMAVGSKLMYSPSDILGTGCEGTVVYRGTFDGREVAVKRVVSEFVKFAHREADLLRESDTHPHVIRYFCMESDSQFRYLALELCIASLNDYVEQKEVQQNVTIALRDIMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLISASTSYPVDIFSLGCIFYYVLTSGTHPFGKSLHRQANIVNGEYTLNKLADLDDWSLADDLISSMLNVEPLHRLTADAVLNHPFFWTSEKRLAYFSDVSDRVEKEEDNSPVVRRIETDARIVVCGGWREKICDALKEDLRKFRTYKSFSVRDLLRAMRNKKHHYRELPEDVRQSLGDIPDQFLHYFTSRFPRLLLHVYKATEYCSGEAVFKRYYSDDVRARMYPIVEEEERVRKKIKEEMANEVWARAPKPVEQRTPLKLDKRNIKKKSNPNTD
What is the function of this protein?
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:11779465).  The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes (PubMed:11779465).  Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis (PubMed:11779465, PubMed:16184190).  Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 and many other genes, upon ER stress (PubMed:18216284, PubMed:16184190).  By activating the UPR pathway during non-lethal hypoxia pre-conditioning, confers adaptive protection to subsequent exposure to hypoxia (PubMed:20733002).  ire-1 and pek-1 are redundant genes that control a pathway essential for larval development and survival (PubMed:11779465, PubMed:16184190).  Plays a role in the nuclear retention of unspliced mRNAs (PubMed:23149939).
What are the official names of this protein?
Serine/threonine-protein kinase/endoribonuclease ire-1, Inositol-requiring protein 2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: RNH2_METBU
Sequence: MKIIGIDEAGKGPVIGPMCIGGVRIDEDKSNALKNLGVADSKKLSPKRRVHLAAQIKKYADGWFVYEVSPNQIDELRKLMSMNDIMVLAFGSVIEELPSDKIYADAADVKEERFGKRLFDNYMEKHPDVSPPEVISKHGADDLFPVVSAASILAKVRRDELIEKIKVDMGVDIGSGYPSDPKTKKFLENWYRENSSFPDIVRHSWKTAQKFIQ
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSN1_XENLA
Sequence: MNDTSERRSNENSESQSNGQTQSSSQQVLEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRFDGQLIYTPFTEDTESVGQRALNSILNATIMISVIIVMTILLVVLYKYRCYKVIHGWLIISSLLLLFFFSYIYLGEVFKTYNVAVDYITLALLIWNFGVVGMICIHWKGPLLLQQAYLIMISALMALVFIKYLPEWTTWLILAVISVYDLVAVLSPKGPLRMLVETAQERNETLFPALIYSSTMIWLVNMADGDPGLKQSASTKTYNTQAPTAHPRSDSAASDDNGGFDTTWEDHRNAQIGPINSTPESRVAVQALPSNSPPSEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
What is the function of this protein?
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).  Requires the presence of the other members of the gamma-secretase complex for protease activity.  Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.
What are the official names of this protein?
Presenilin-1, PS-1, Presenilin alpha, PS-alpha.
What is the protein family that this protein belongs to?
Belongs to the peptidase A22A family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane. Cell projection, axon. Synapse. Cell projection, neuron projection.
Protein: ECOTL_SYNPV
Sequence: MAFTQSLKTISGCGIWASLLLVSGLEPASAIPRLNLSGYPQPAPGLQRWVIQPSGLLPKSSDPTVSSHPLDWRIQLIVGQEVTLDCNQKQLSGPGMTMRMLPQASGKALFEVKAPLRVISTKMACSPEQPVKRSFLSLGRQPYFVPYNPSWPIVVDLPKGAELRWRLWKAETLQKTAISL
What are the official names of this protein?
Putative ecotin-like protein.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I11 (ecotin) family.
Protein: MAK_HUMAN
Sequence: MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCVPINLKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQPKTSQQPLQPIQPPQNLSVQQPPKQQSQEKPPQTLFPSIVKNMPTKPNGTLSHKSGRRRWGQTIFKSGDSWEELEDYDFGASHSKKPSMGVFKEKRKKDSPFRLPEPVPSGSNHSTGENKSLPAVTSLKSDSELSTAPTSKQYYLKQSRYLPGVNPKKVSLIASGKEINPHTWSNQLFPKSLGPVGAELAFKRSNAGNLGSYATYNQSGYIPSFLKKEVQSAGQRIHLAPLNATASEYTWNTKTGRGQFSGRTYNPTAKNLNIVNRAQPIPSVHGRTDWVAKYGGHR
What is the function of this protein?
Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity).  Phosphorylates FZR1 in a cell cycle-dependent manner.  Plays a role in the transcriptional coactivation of AR.  Could play an important function in spermatogenesis.  May play a role in chromosomal stability in prostate cancer cells.
What are the official names of this protein?
Serine/threonine-protein kinase MAK, Male germ cell-associated kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.
Protein: ATPG_BIFA0
Sequence: MASQLALKSRIASTGSLEKIFNAQEMIAASHIAQARQLALDSKPYTDAIFDAVQTLVSHTHISHPIVKKDEGNPRVAVLALTADRGMAGAYTSSIIRETEDLLARLEGEGKQPQLYVYGRRGVSYYHYRNRPLAQSWEGDTEKPGVEVANAISRALLKAYMEPVDEGGVAELYIVYTEFINMVVQKVRVLRMLPVEVVKEDKSHLNVPDTTTAPQVRPLYSFEPSLDEVLDTVLPRYVRSRIHECLFEAAASEVACRQNAMHTATENARDLINDLTRKLNASRQASITQELTEIIGSADALNKKEE
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, ATP synthase F1 sector gamma subunit, F-ATPase gamma subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DERF3_DERFA
Sequence: MMILTIVVLLAANILATPILPSSPNATIVGGVKAQAGDCPYQISLQSSSHFCGGSILDEYWILTAAHCVNGQSAKKLSIRYNTLKHASGGEKIQVAEIYQHENYDSMTIDNDVALIKLKTPMTLDQTNAKPVPLPAQGSDVKVGDKIRVSGWGYLQEGSYSLPSELQRVDIDVVSREQCDQLYSKAGADVSENMICGGDVANGGVDSCQGDSGGPVVDVATKQIVGIVSWGYGCARKGYPGVYTRVGNFVDWIESKRSQ
What are the official names of this protein?
Mite allergen Der f 3, Allergen Der f III.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9_PSYIN
Sequence: MEIILQDTVANLGKLGDKVVVKSGYARNFLFPQQKAVPANKANLEAFETRRVELEAKQAANLAAAEKRGAALAALEAVVIASKAGDVGKLFGSIGTRDIATAITAAGVPVVKSEVRLPEGALRNTGLFEIAVVVHSEVSTIVKIEVVQAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: NU4LM_PLAHE
Sequence: MSLTYMNMFMAFTISLLGLLLYRSHMMSSLLCLEGMMLSLFVMMTMVILNTHLTLASMIPIILLVFAACEAALGLSLLVMVSTTYGMDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: PER6_CYCRE
Sequence: AQVESVCPGVVSC
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 6.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted. Secreted, cell wall.
Protein: Y9343_DICDI
Sequence: MRLPYSSSKPIPTNNNNNNNNTNNGISINKIPKSHYSYYQTQENNKPQQSQQHPLLQHQQQQQQQQQQQQQQQQQQQQQQQQQQPQQQPQIATITATISISPSINNIIVNNSPIKTPSKKHRSSSKKSPSSSKKLNKVLSCCFVCQSSISNPFIVKETPKANHYFCSIQCFAQASP
What are the official names of this protein?
Uncharacterized protein DDB_G0288467.
Protein: MOBA_RHIME
Sequence: MTGAPSHATFPPAVILAGGLSSRMGRPKAGLVLGGRSMLTRVIERLRPQVAGIAINLNADPDPASAFGLEVVPDTIPGFVGPLAGILAAMRHTVRKSPGASHVLTVPVDTPLFPKSLAARLKTAITSGGEIAVAFSAGEMHPLFALWPVALADDLEAWIHADEKRRVRAFIARHESATVEFPLIPTAAGPLDPFFNINTPEELRQAEAWLPYLEDREP
What is the function of this protein?
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
What are the official names of this protein?
Molybdenum cofactor guanylyltransferase, MoCo guanylyltransferase, GTP:molybdopterin guanylyltransferase, Mo-MPT guanylyltransferase, Molybdopterin guanylyltransferase, Molybdopterin-guanine dinucleotide synthase, MGD synthase.
What is the protein family that this protein belongs to?
Belongs to the MobA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_ACIET
Sequence: MTFLAIDVGNTRLKWALFDAAQPGAGLLAHGAEFLDHIERLAEGPWSHLPAPRHMLGCVVAGDAVKRRVAEQMELWDVPARWVVPSAQEAGVINGYDHPTRLGADRWVAMIGARHRLLAQGPARPLIVVMVGTAVTVEALDAEGRFLGGLILPGHGIMLRALESGTAGLHVPTGEVRLFPSNTSDALTSGGTYAIAGAVERMYQHLRQHCGQEPACMMTGGAGWKMAPSMTRPFELVENLIFDGLLEIAARRFAELPA
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VKTH1_BUNCA
Sequence: RKRHPDCDKAADTRI
What is the function of this protein?
Neurotoxin T1-1 is a presynaptic neurotoxin of the venom that exhibits indirect hemolytic activity against human erythrocytes.  The B chain is homologous to venom basic protease inhibitors but has no protease inhibitor activity and is non-toxic.
What are the official names of this protein?
Kunitz-type serine protease inhibitor homolog T1-1 B chain, Neurotoxin T1-1 B chain.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family.
What are the subcellular locations of this protein?
Secreted.
Protein: LTE1_ASHGO
Sequence: MRAEGNDMAESGRAVFSAADYYPAPSGRVITYAAGGRGRQIMAADVTALVAALTSPVDGVEYELFADFFLVYRNFLEARRLLELLEARFDWSLGEIGAGRAKARVVGEITLVRTFVLLRHWVINYFAQDFLPDVALRERFLAFVNGLGGAAGGTRPKIVANIVVSLKKTWAYTVRLIWDDLDLEREFELRSADAWLQFQIPDVTQLKTEAGLQRDSRLSFYARQSSTNPSFRNESVLSLYRPKDNFQLPVRNNDYNIKQGTRIKKRTASMFLYPQDSLNAPSGNQKPQCSLEPPFPAHSHVRKISHISKVTNVSNVIKEVAYPTSPAVESFFPPTPSKKLEFTVNSTYVPPAAAECSREPSAQKKPRSPNGYRAVTGLLSKWRMNHLSRHKACDRTSTVEPAMDNLIKYVFSISSLESPKGDIQEEREISPSKFDILSARTIEEVEHLITVENEVLQKVTAHEGKVPITSSSAREARFPPLLNEAPLLDQAPLGNGQEYSVIDNLNLYRTVSTIATSVIKLTRTASQRQTKVTLPPPPPLRQRPTSLSAFRGSSSRMLLSDSLRRDGYQNSKASLHLRPLASADENAEGSSVQASNPPQVIFHTHALIKTPTDKVFDAKAVEDTSPKTSLVSTQVTDARPPSYESTITYDSDLQDITMRDYNTSNQTENHNDGTLDTNQPILNRKTNHSNLREFLFEASTSGSPAAHTTQEPTDESTGRLGACPTVMRSISEPIPTVMRSNNGDTHTKAKPEFNIQSHDDTFSRKPMRPSLLSPPINIRGSFDTLHRKNVPAPISVPPNPVTKNASVSPASGRISIIKKSGNRTSPTTRSPLLDTTSAFMEKTDSFAKQEASLNALENDLQAILITTGRRSSTFSKSGTDSTIATNVLLESIQTSPQKNTHLMTNISEDDSASNTDTKPMEFSSVGIESSASNSSSFADALCEPANRSSPSHNPYSGQCTTIEDRYRRSRFASQPDSLLGYINENGNKYIFSPGETAEDASPKKDMETLKTKFMTTKEPPVCPSGNDADLALIISKLKETNPSAERIETENPNDDANNLTPPATSSSNNENSSDPVAVALMKLEGTFAKPAKEDNTASKLNSPRSSVLAKEVEKLDFQKWRFPSSKTMNKRQSMFIERRRTMTDIFSSATEDTSSEEQSPKLSDREIRELLETYKLQDPRLNIKNVEHHVPFILMYDSCSIAKQMTLIEREVMNEIDWKDLLDLNMKKSLPRVTSWLQLLLHNEELSGIDLAIARFNLTVDWIISELVMTTDIKLRRNAIQRLIHVAEHCRMYQNYNTVMEIVLALNSVVVQKFTSSWRLIEPADMLTWEHLKSIPSLDRNYHNVRNLLNSIDPIKGCIPFLVVYLSDLALNSEKRDWIVPNEIVNYNKFQTNVQIVKNFIQRVQWARFYDIRADEDLLSKCVYISALSHEEIGYLTSF
What is the function of this protein?
GDP-GTP exchange factor component of the mitotic exit network (MEN).  Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis.  May also be involved in proprotein-processing in the secretory pathway (By similarity).
What are the official names of this protein?
Guanine nucleotide exchange factor LTE1.
What is the protein family that this protein belongs to?
Belongs to the LTE1 family.
What are the subcellular locations of this protein?
Cytoplasm. Bud.
Protein: YL4M_CAEEL
Sequence: MFSSRHILSNVRPIIKNLDLTRGFSDRKTKYFDLNDLIKTVNVTYKTGVNLEETTTVESKYVDVTPSSNTKGTVVTLSGSPGTHNDFKYMKSFFEQKKIRLICTNYPGSEFVTGGLHNSYTNQDRNSYMKSLMETLELKNVNRLIIMGHSRGGENALQLTSMLSNDENWPLVGAVMINSPGFAPHKGISKRMGTINFIISLIKRHNKTINSILHPILHYFYNNLIGLRVSHGKVAAAAILPMQTFAFDEQKLSIDDLRAKPGIRAFYGYGSKDFLIDEHQSEEVAMYFSEEDHYVISNKQDAEKAIKEARKSFTTGKQFVTANFKEEGHFLQKTYPEFIVEVVDSIFDADKEVDTKI
What are the official names of this protein?
Uncharacterized protein F35H12.5.
Protein: DUHM_BPPM6
Sequence: MKVIKTRNVQQALPEALYQLSFEGVRRDSRNGPVFMFPEPVTTVYLRPAERVLFWAERDANPFFHLMESLWMLGGRNDVEYVARFVDRMRSYSDDGLTFHGAYGFRWRQHFFEDQLPKIIAALKENRDDRRQVLSMWDADADLGRQGKDLPCNLQAIFQIACDGRLDMTVTNRSNDLIWGAYGANAVHFSYLHEYVARSVGVEQGIYRQVSANFHAYEEVLNKVAPLADLAANPMTGTETPDPYAAGIAEPYPLMSTDPEEWNQELMMFLSEPDAVGFRDPFFRRVAIPMMKAHKAFKQTSNPSRFDAALAELDNVAATDWKLAGVEWIERRRAAFEARKARAMDDGVAYE
What is the function of this protein?
Catalyzes formation of 5-hydroxymethyldeoxyuridylate (5HMdUMP) as a step in the pathway that replaces dTMP by thymidine hypermodifications in the viral genome (PubMed:34522950).  As a final result of the pathway of hypermodification, 5-aminoethyl-2'-deoxyuridine (5-NedU) substitutes for about 30% of thymidines in the viral DNA (PubMed:34522950, PubMed:29555775).  These modifications probably prevent degradation of viral genome by the host restriction-modification antiviral defense system (PubMed:34522950).
What are the official names of this protein?
Deoxyuridylate hydroxymethyltransferase, Deoxyuridylate hydroxymethylase, dUMP hydroxymethylase, dUMP-HMase, gp58.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family.
Protein: MTRG_METMP
Sequence: MSEIPTVVTPTKDYKRLQAKLDEIENTVENTNAEIIQRTGKKAGRDVGIAYGLAIGFIFVYVLGTVLPLFDLIK
What is the function of this protein?
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin.  This is an energy-conserving, sodium-ion translocating step.
What are the official names of this protein?
Tetrahydromethanopterin S-methyltransferase subunit G, N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit G.
What is the protein family that this protein belongs to?
Belongs to the MtrG family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: Y1982_STAHJ
Sequence: MKFLSFNYKDAESYGVKVKRKDAVWDLKKVFAEFGEGDFHPQTLLEGLQQNQTLDFQEQVRKAVVAAEDSGKADEFKIAFNDIEFLPPVTPPNNVIAFGRNYQDHASELNHEVQRLYVFTKAASSLTGDESTIPNHKDITDQLDYEGELGIVIGKSGEKIPKALALDYIYGYTIINDITDRKAQNEQDQAFLSKSLTGGCPMGPYIVTKDELPTPENVNIVTKVNNDIRQDGNTSQMINKIDDLIEEISKYVALHPGDIIATGTPAGVGAGLQPPQFLQPGDEVKVTIDNIGTLTTYIAKD
What are the official names of this protein?
Uncharacterized protein SH1982.
What is the protein family that this protein belongs to?
Belongs to the FAH family.
Protein: TRM1_SULIL
Sequence: MKLKEVTEGKVRIFVPDPKEYMIEGKFDPSWAPVFYNPKMTFNRDLSVIVVSLLKPKIILDALSATGIRGIRYYVESWKSEQLILNDKNSTAASLIQINVKNNGIENAKIYNKDANALLYEIKSEYIDIDPFGSPVPFILSSVNATIRNGIVAFTATDLSPLEGSSRTSCRRKYDAINYKLSSSKELGLRILIGKIIREAATLEKTVHPLFSFYADYYYRLFVIVESGARKADENINKNLKYFGECPRCGFQTFVDENCKTKCPICGENFIIIGPLYIGPLHNMEFLKRMIDTYSDFNYLSSFNRIQKLLNVIEKEAKYKSVFYNISKLASKLKVSAIPPIDSILECLGDASKTHFAPTGIRTDKGYEEIIRCVKSLR
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: UREH_HELHP
Sequence: MSSFAQKSILKLKTKRGLNGKNIIEEMFFTPPLKIISPLEDEDIAEIMLISVSAGLLKDDCQDIQIHIGKESKIRLISQSYEKIHDTQDGYASKHTQITIEENAFLDYAPLPILPFKDSSFKNTTDIYLSKNARLHYSEIICAGRVAMGEIFDFSELSSRLRIYKENHLVFFENMNLKPAQMAMQNICLFDKYTHALSMVIFDDLIEVQALEQKIKNSSLNVGISTNNGGIIIKALDNQSERLLQFKKDLAL
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreH.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_SYNWW
Sequence: MIDKEQAAPEMIEKVVTIRRVAKVVKGGRRFSFSALVVVGDGEGKVGTGKGKATEVPEAIRKAIENAKKNMLSVPLIDGRTIPHEILGIFGAGQVLLKPASEGTGVIAGGPVRAVLEAAGIKDILTKSLGSDNATNIVHATMEGLRSLKRVEDVARQRGKTIDEIMN
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: DAPA_METJA
Sequence: MFKGVYPAIITPFKNKEVDFDGLEENINFLIENGVSGIVAVGTTGESPTLSHEEHKKVIEKVVDVVNGRVQVIAGAGSNCTEEAIELSVFAEDVGADAVLSITPYYNKPTQEGLRKHFGKVAESINLPIVLYNVPSRTAVNLEPKTVKLLAEEYSNISAVKEANPNLSQVSELIHDAKITVLSGNDELTLPIIALGGKGVISVVANIVPKEFVEMVNYALEGDFEKAREIHYKLFPLMKAMFIETNPIPVKTALNMMGRPAGELRLPLCEMSEEHKKILENVLKDLGLI
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEPT_BACSU
Sequence: MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELKSIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGKDIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKHPEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKITIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEETKLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEIVNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNMVKAVNVIVEIAKQFEAQA
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AEE22_ARATH
Sequence: MDNMELCEANNVPLTPITFLKRASECYPNRTSIIYGQTRFTWPQTYDRCCRLAASLISLNIAKNDVVSVVAPNTPAIYEMHFAVPMAGAVLNPINTRLDATSITTILRHAQPKILFIHRNFEPLAREILHLLSCDDLQLNLLVIFIDEYNSAKRVSSEELDYESLIQMGEPTSPLVENMFRIQNEQDPISLNYTSGTTADPKGVVISHRGAYLTSLGVIIGWEMSTCPVYLWIFAYVSLQWMDVYMGNSSARGHQCVYEPRNPLDMSHRSGPVHLMTGGSPLPAALVKKVQRLGFQVLHVYGLTEATGPALFCEWQDEWNRLTENQQMELKARQGLGILSVAEVDVKYNETQESVPHDGKTMGEIVMKGNNIMKGYLKNSKATFEAFKHGWLNTGDVGVIHPDGHIEIKDRSKDIIISGGENISSVEVENILYKHPRVFEVAVVAMPHRVWGETPCAFIVLQKGETNKEDDEYKFVAREKELIDYCRENLPHFMCPRKVVFLEELPKNGNGKILKPNLRAITKGLVAEDEANVIS
What is the function of this protein?
May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs.
What are the official names of this protein?
Probable acyl-activating enzyme 22.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: SYP_STAHJ
Sequence: MKQSKVFIPTRRDVPAEAEALSHQLLLKAGLIKQSTSGIYSYLPLASRVLNNISKIIREEMESIDAVEILMPALQQAELWEESGRWGAYGPELMRLKDRNGREFALGPTHEEVVTSIVRDELKSYKQLPLTLFQIQSKFRDEKRPRFGLLRGREFIMKDAYSFHADEASLDETYQDMYNAYDRIFKRVGINARPVVADSGAIGGNHTHEFMALSEIGEDTIVYSEHSDYAANIEKAEVVYHPNEKHTEVAELEKVETPNVKTAQELADFLNRPVDEIVKSMIFKIDGEFIMFLIRGHHELNDVKVKAFFETDNVEMATQEEIVNLLGANPGSLGPVHDKDIRIFADNYVRDLNNLVVGANEDGSHYINANLDRDFKVDEFGDFRFILEGETLSDGSGEAKFAEGIEVGQVFKLGTKYSEAMNATFLDNQGKAKPLIMGCYGIGVSRTLSAIVEQNNDENGIIWPKSVTPFDLHLITINPKKDEQLELGDQLYKELQQQYDVLYDDRKDRAGVKFNDADLIGLPIRIVVGKNASEGIVEVKVRQTGESEEVHINDLNTHIATLYSNL
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXD_TRIEI
Sequence: MKFSKLASKLGSETITCSLEKINHLDPDIQGVAAIDEAKPGTLSYIEGAKFANYLKTTNASALILPMDETLQKLAGERGIGWLSSKEPRLLFAQAIALFYRPFQPTPEIHATSIVHPTAKVGKNVYLGAHVVVEAGVKIGDNVCIYPNVVIYPNVEIGENTILNANCSIHERSQIGKGCVIHSGAVIGGEGFGFVPTPEGWFKMEQSGKVILEDGVEVGGNTTIDRPAVGETRIGKNTKLDNLVQIGHGCKIGKNCALAAQVGLAGGVKLGDNVILAGQVGVANQAKIGDRAIATAQAGVHNDVAAGEIVSSSPAVPNKIYLKASAIYKRLPEIYQFVKQMKRKL
What is the function of this protein?
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor.  Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-3-O-acylglucosamine N-acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxD subfamily.