PharMolix/UniProtQA huggingface dataset:
Protein: S1FA1_ORYSJ
Sequence: MADQSNNMIIEEVNKGLNPGTIVLLVVATLLILFFVGNYALYMYAQKTLPPRKKKPVSKKKLKREKLKQGVSAPGE
What is the function of this protein?
DNA-binding protein that specifically recognizes a negative element (S1F) within the RPS1 promoter.
What are the official names of this protein?
DNA-binding protein S1FA1.
What is the protein family that this protein belongs to?
Belongs to the S1FA transcription factor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YDJC_CLOB8
Sequence: MRLIMNADDFGISKAINLGIIEGFKNGIVTSTTLMCNMETTEHAVNLAKENSKLGVGIHLVLTAGRPLSKNVKTLVDNEGNFLKYDKMVESACIEDIRIEFRNQFEKFLSFGIVPTHIDTHHHVHSIESVFEVVAELAKEHNIPIRHIKAIGEEKYENIKTTTEFIDSFYNLSMIEPQMLINLLDDNMNVDSLEIMCHPGYLDSKILSSSSYAYPRVKELETLTNKEVIQFINEKNIELINFKDI
What is the function of this protein?
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
What are the official names of this protein?
Carbohydrate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family.
Protein: ILDR1_XENLA
Sequence: MIPPRALLLISVWMVSGGRTLLVTVQDTQRYTMLFSSIILKCDYSTSAQIQDVAVTWRFKSFCKDPIFDYYSAAYQASLSLNQDPANDCNDNQREVRIVIQKRGQNEPVLGVDYRQRKITIQNKADLVISEVMWWDHGVYFCSVEAQGDTSGDPDKEVKLVVLHWLTVLFIILGALFLFLLIGICWCQCCPHCCCCYVRCPCCPTRCCCPEEALARHNYMKQMESMTPWMLDRPYYAGADRNSQHSSYQLNPLLQRDLSLQSSLPMPAPMSFSPPNNKVLDFLETEIKNLNTAQPLMSAPHYGGASHHPSMLSSLSEVGVREVDRRVIQLPPLVEHIVSSHRSSNSSHQRRNMGSWDPLDGERDRRRNRQLDDSLSNETNWRAQERQHSDRSSGHRRDPPNNRRPRRDVSPPRRYGDSYSDESANNDPRGRSNPHSDRARPTERRRSPERGDQGRRGSPDRYSRSQRHRRSYSPPHRRDSWSSEDETRNNQRGRGRRERSYEWPEEKPPSYKSLEICAGKAPTQRPGAVRQSDRASSRSGRSMVI
What is the function of this protein?
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs).
What are the official names of this protein?
Immunoglobulin-like domain-containing receptor 1.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. LISCH7 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction.
Protein: RL31_AQUAE
Sequence: MKKGIHPELKPTTFVCGCGNTFTLLSTKGGTVYLEVCNQCHPFYAGKLKIKPAYYEMLAEFEGGKKEE
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: TIG_RHOP2
Sequence: MQVKETVADGLKREFEVNVPAADIDAQVDARLVDLKDKVKLNGFRPGKVPVSHLKRVYGRSVAAETIDKLVRETNDGIFAERGFRLATEPKITMPQDQKVVEDILAGKSDLNYTVAIEVVPTIELADFKSFSVEKPVVEVSDSDVDDAIKRIAEANRAYADKAEGAKAESGDRVTISFKGSIEGVPFDGGTGEDIPVVIGSNSFIPGFEDQLIGIAVGETRTIKVTFPTNYASETLAGKPAEFETTATKVEAPQDTTIDDEFAKTLGMESLDKLKEAAKARLAAEYAGATRLRVKRQLLDRLDETHKFDAPPSLVEQEFAVMWQSINAEMQQNGKSFADEDTTEEAAREEYRKIADRRVRLGLVLSEIGEKNKIQVTDDEVSRAVIERARQMPGREKEVWDFYRSNAEALAQLRAPIYEDKVVDFILELATVTEKPVTREELYKDDDDKTAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: LEUD_STAAN
Sequence: MAAIKPITTYKGKIVPLFNDNIDTDQIIPKVHLKRISKSGFGPFAFDEWRYLPDGSDNPDFNPNKPQYKGASILITGDNFGCGSSREHAAWALKDYGFHIIIAGSFSDIFYMNCTKNAMLPIVLEKSAREHLAQYEEIEIDLPNQTVSSPDKRFHFEIDETWKNKLVNGLDDIAITLQYESLIEKYEKSL
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RS7_SHEB2
Sequence: MPRRRVVGQRKILPDPKFHSELLAKFINVIMQDGKKSTAEKIIYKALDVVAEKKSESHLTILEAALDNVRPSVEVKSRRVGGSTYQVPCEVRPVRRNALAMRWLVEAARKRGEKSMALRLAGEMLDASENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: SYK_ALIB4
Sequence: MFENIYIQQRIEKANKLREDGINPYSNESSRNCTISKYLNVNSDIFQLEEKRDENRNYTVAGRIKFFRLMGKASFLKIEDESGMLQIYVARDNLPENFYNEVFKKNIEVGDIIEISGYPFVTGHGELSLHADSLKILTKAISPLPEKFHGIQDKELRYRQRYLDLIMNSEVRKTFHIRSKVISLTRRFFENKGFLEVETPMMHPIAGGANAKPFVTHFNALGVDRFLRIAPELYLKRLIVGGFEAVFEINRNFRNEGMDATHNPEFTSIEFYWAYKTYKDLIVLTKEYFEYLFENLNLPTILPYGEFKIDFNKFSEIPLIQSLYEIGGVPQDIVEDKDKILAFLKANNLEANANLNLGQLQGELFDEFVEAKLINPTFITEYPVEISPLARRSDEKPHLTDRFELFIAGKEIANAFSELNDPIDQLQRFEGQIAAKEAGDDEAHEMDEDFVNALSYGMAPTAGQGIGIDRLVMMLTNEHSIRDVLLFPAMKPIKQEIDLYSEEK
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLRG1_RAT
Sequence: MADNSIYSTLELPAAPRVQDDSRWKVKAVLHRPCVSYLVMVALGLLTVILMSLLLYQRTLCCGSKGFMCSQCSRCPNLWMRNGSHCYYFSMEKRDWNSSLKFCADKGSHLLTFPDNQGVNLFQEYVGEDFYWIGLRDIDGWRWEDGPALSLSILSNSVVQKCGTIHRCGLHASSCEVALQWICEKVLP
What is the function of this protein?
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands.  May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells (By similarity).
What are the official names of this protein?
Killer cell lectin-like receptor subfamily G member 1, Mast cell function-associated antigen.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: LIPA_BACCZ
Sequence: MTKQTEYKRKPEWLKIKLNTNENYTGLKKMMRSKNLHTVCEEAKCPNIHECWAVRKTATFMILGAVCTRACRFCAVKTGLPTELDLQEPERVADSVVQMGLKHVVITAVARDDLKDGGAAVFAETVRAVRRKNPFTSIEVLPSDMGGVEENLKMLMDAKPDILNHNIETVRRLSDRVRARAKYDRSLEFLRRAKEMQPDIPTKSSIMVGLGETREDLIEAMDDLRANNVDILTLGQYLQPSKKHLPVLKYYPPAEFAELKEIALSKGFSHCEAGPLVRSSYHADEQVRSAKENTAEAK
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS27_NEUCR
Sequence: MVLAVDLLNPSPASEARKHKLKTLVPAPRSFFMDVKCPGCFTITTVFSHAQTVVICQGCTTVLCQPTGGKARLTEGCSFRRK
What are the official names of this protein?
40S ribosomal protein S27, Cytoplasmic ribosomal protein 6.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: HHEXH_CAEEL
Sequence: MDQKFYISSLLQEDTPSKEKPETSSESPIPTGSECSLNESSDTTLDQKMEPNKKMFNGTLDFNPWICHVSQQLAAQLSQNGKNRPGAPNQVPLLNMNVNQTMGNMWDPRLSWLYPYMSKSPQKRKGGQIRFTNEQTDALEHKFDSHKYLSPQERKKLAKSLSLSERQVKTWFQNRRAKWRRVRKDGEDEDEMPNGASARSLGQLQSSNPFLSHG
What is the function of this protein?
Transcriptional repressor (By similarity).  Involved in pharyngeal development and required for the formation of the pharyngeal isthmus (PubMed:15282157, PubMed:16806153).  Plays a role in modulating cytoskeleton in the muscle cells of the isthmus (PubMed:16806153).  Regulates expression of the acetylcholinesterase genes ace-1 and ace-2 (PubMed:16806153).  May regulate its own expression (PubMed:15282157).
What are the official names of this protein?
Homeobox protein HEX homolog pha-2, Defective pharyngeal development protein 2.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL35_CLOBK
Sequence: MPKMKTKRAAAKRFKVTGTGKLKRAKAFKSHILTKKSRKTKRNLRKAGYVSESQEKVMKKVLPYL
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: Y1738_BORPE
Sequence: MNNDIVAGKWKQLTGKAKAAWGELTDDELTRTEGNAERLAGLIQERYGKTKEQAQREVREFFDRNP
What are the official names of this protein?
UPF0337 protein BP1738.
What is the protein family that this protein belongs to?
Belongs to the UPF0337 (CsbD) family.
Protein: DAPB_SHEFN
Sequence: MTAKVRIAVVGASGRMGRTLIESAKQQQVIILGAAIERTGSSLIGIDAGVLAGVGAMNVAITDSLDKVVNDFDVLIDFTSPESSIIHLDWCAKNHKAIVIGTTGFNHAQKEQINAYSEQVPVVLAPNMSVGVNVMWKLLALATEVMGDYTDIEIIEAHHRHKKDAPSGTALKMGEIIAQTLGRDLEQCAVFGREGITGERDPNTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAMRAAFWLSDQNAGLYDMQQVLGLN
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRP_SHIB3
Sequence: MKKNQFLKESDVTAESVFFMKRRQVLKALGISAAALSLPHAAHADLLSWFKGNDRPPAPAGKPLEFSKPAAWQNNLPLTPVDKVSGYNNFYEFGLDKADPAANAGSLKTDPWTLKISGEVAKPLTLDHDDLTRRFPLEERIYRMRCVEAWSMVVPWIGFPLHKLLALAEPTSNAKYVAFETIYAPEQMPGQQDRFIGGGLKYPYVEGLRLDEAMHPLTLMTVGVYGKALPPQNGAPVRLIVPWKYGFKGIKSIVSIKLTRERPPTTWNLAAPDEYGFYANVNPHVDHPRWSQATERFIGSGGILDVQRQPTLLFNGYADQVASLYRGLDLRENF
What is the function of this protein?
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons.  Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms.  MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal.  The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
What are the official names of this protein?
Protein-methionine-sulfoxide reductase catalytic subunit MsrP.
What is the protein family that this protein belongs to?
Belongs to the MsrP family.
What are the subcellular locations of this protein?
Periplasm. Note=Is attached to the inner membrane when interacting with the MsrQ subunit.
Protein: XPT_PSEFS
Sequence: MEALHKKIREEGIVLSDQVLKVDAFLNHQIDPALMKLIGDEFAALFKDSGITKIVTIEASGIAPAIMTGLNLGVPVIFARKQQSLTLTENLLSATVYSFTKKTESTVAISPRHLTSSDRVLVIDDFLANGKASQALISIIKQAGATVAGLGIVIEKSFQGGRAELDAQGYRVESLARVKSLAGGVVTFIE
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFNA_METJA
Sequence: MRNMQEKGVSEKEILEELKKYRSLDLKYEDGNIFGSMCSNVLPITRKIVDIFLETNLGDPGLFKGTKLLEEKAVALLGSLLNNKDAYGHIVSGGTEANLMALRCIKNIWREKRRKGLSKNEHPKIIVPITAHFSFEKGREMMDLEYIYAPIKEDYTIDEKFVKDAVEDYDVDGIIGIAGTTELGTIDNIEELSKIAKENNIYIHVDAAFGGLVIPFLDDKYKKKGVNYKFDFSLGVDSITIDPHKMGHCPIPSGGILFKDIGYKRYLDVDAPYLTETRQATILGTRVGFGGACTYAVLRYLGREGQRKIVNECMENTLYLYKKLKENNFKPVIEPILNIVAIEDEDYKEVCKKLRDRGIYVSVCNCVKALRIVVMPHIKREHIDNFIEILNSIKRD
What is the function of this protein?
Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis (PubMed:15715981).  Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis (PubMed:24891443).
What are the official names of this protein?
L-tyrosine/L-aspartate decarboxylase, TDC/ADC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. MfnA subfamily.
Protein: ISCS_SALCH
Sequence: MKLPIYLDYSATTPVDPRVAEKMMQFLTLDGTFGNPASRSHRFGWQAEEAVDIARNQIAELVGADPREIVFTSGATESDNLAIKGAANFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLAPQRNGIIDLNELEAAMRDDTILVSIMHVNNEIGVVQDIATIGEMCRARGIIYHVDATQSVGKLPIDLSQLKVDLMSFSGHKIYGPKGIGALYVRRKPRIRIEAQMHGGGHERGMRSGTLPVHQIVGMGEAYRIAKEEMETEMARLRGLRNRLWNGIKDIEEVYLNGDLEQGAPNILNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGMNDELAHSSIRFSLGRFTTEEEIDYTIDLVRKSIGRLRDLSPLWEMYKQGVDLNSIEWAHH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.  Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KVD08_HUMAN
Sequence: MDMRVPAQLLGLLLLWLPGARCAIWMTQSPSLLSASTGDRVTISCRMSQGISSYLAWYQQKPGKAPELLIYAASTLQSGVPSRFSGSGSGTDFTLTISCLQSEDFATYYCQQYYSFP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 1D-8.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: ENY2_DROGR
Sequence: MTICDTVDQYTIMSGDRLKIKDLLCNRLTECGWRNEVRLLCRNILLEKSANNSVSVDQLISEVTPKARTLVPDAVKKELLMKIRTILAETDEDN
What is the function of this protein?
Involved in mRNA export coupled transcription activation by association with both the AMEX and the SAGA complexes.  The SAGA complex is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.  Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B.  The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.  Required for nuclear receptor-mediated transactivation.  Involved in transcription elongation by recruiting the THO complex onto nascent mRNA.  The AMEX complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket).  AMEX participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity).
What are the official names of this protein?
Enhancer of yellow 2 transcription factor.
What is the protein family that this protein belongs to?
Belongs to the ENY2 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Cytoplasm.
Protein: MSCL_ECOLI
Sequence: MSIIKEFREFAMRGNVVDLAVGVIIGAAFGKIVSSLVADIIMPPLGLLIGGIDFKQFAVTLRDAQGDIPAVVMHYGVFIQNVFDFLIVAFAIFMAIKLINKLNRKKEEPAAAPAPTKEEVLLTEIRDLLKEQNNRS
What is the function of this protein?
Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.  Forms a nonselective ion channel with a conductance of about 4 nanosiemens.  Participates in the regulation of osmotic pressure changes within the cell.  Opens at a pressure just below that which would cause cell disruption and death.  The force required to trigger channel opening depends on the membrane lipids composition.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSI2_ARATH
Sequence: MGGVCSCVFKDDDKKKKLRSNDDDKSRGFSGKLKSMRRSKTSDSYYSDNYGGSRRKSSKPDEVVFNFSGELGPMPPLRNDSTKFMQRNSFMGRAGVMGLEKAVEVLDTLGSSMTRMNPSNAYLSGVTSSRGGKVTILAFEVANTIAKGAALLQSLSEENLKFMKKDMLHSEEVKKLVSTDTTELQILAASDKREELDLFSGEVIRFGNMCKDLQWHNLDRYFMKLDTENSQHKLLKDDAEARMQELVTLARITSELYHELQALDRFEQDYRRKLAEVESLNLPRRGEGIVILQNELKQQKKLVKSLQKKSLWSQNLAEIIEKLVDVVSYIRQTIVEVFGNNGLRDNEGEQGRERLGEAGLSLHYANLIQQIDNIASRPSSLPSNVRDTLYNALPATVKTALRPRLQTLDQEEELSVPEIKAEMEKSLQWLVPFAENTTKAHQGFGWVGEWANSRIEFGKGKGKGENNGNPTRLQTLHHADKPIVDSYVLELVVWLHRLMKSSKKRAHGVKLQETNHVSPPNNRTISNTQLSLSPDFTYKNQLSLEDRLLLDRVQSIRFGPNLSKSQELVGLKKNKKGFKIWALSRSTGNSPKVDLSDKNSSSDLDVLDGLDFAFQ
What is the function of this protein?
Promotes seedling growth probably via the regulation of phytosulfokine (PSK) signaling; PSK are peptide phytohormones acting as growth factors (PubMed:25062973).  Involved in PSK-induced root growth (PubMed:25062973).  Together with PSI1 and PSI3, required during vegetative growth and reproduction (PubMed:25062973).
What are the official names of this protein?
Protein PSK SIMULATOR 2, AtPSI2.
What are the subcellular locations of this protein?
Nucleus.
Protein: EPABB_XENLA
Sequence: MNATRAEYPLASLYIGDLHPDVTEAMLYEKFSPAGPIMSIRVCRDIATRRSLGYAYINFQQPADAERALDTMNFEVIKGRPIRIMWSQRDPGLRKSGVGNVFIKNLDDSIDNKALYDTFSAFGDILSCKVVCDEYGSRGYGFVHFETQEAANRAIQTMNGMLLNDRKVFVGHFKSRRERELEYGAKVMEFTNVYIKNFGEDMDDKRLKEIFSAFGNTLSVKVMMDNSGRSRGFGFVNYGNHEEAQKAVTEMNGKEVNGRMVYVGRAQKRIERQGELKRKFEQIKQERINRYQGVNLYVKNLDDGIDDDRLRKEFSPYGTITSTKVMTEGGHSKGFGFVCFSSPEEATKAVTEMNGRIVSTKPLYVALAQRKEERKAILTNQYMQRLATMRAMPGPLLGSFQQPANYFLPTMPQPSNRAFYSPNPVAPVRPAPQWASHQSRPPQYQPPAPLMRAVPPRRMHSNISTMKQASTQVPRVPLQSQRVANIGTQTAGARAQVNASIMRAMPHYKYSCGVRNVQPIGSSAHLQQVLEPAVLMQGQEPLTASLLAAAPLQEQKQILGERIYPLIHEMHPTLAGKITGMLLEIDNSELLHMLESPESLHSKVEEAVAVLQAHQAKESAPKSAPQSLI
What is the function of this protein?
Binds and protects the poly(A) tail of mRNA with or without an AU-rich element (ARE) and prevents mRNA deadenylation.  Stimulates the translation of mRNAs to which it is bound during early development (By similarity).
What are the official names of this protein?
Embryonic polyadenylate-binding protein B, Embryonic poly(A)-binding protein B, ePAB-B, ePABP-B, XePABP-B.
What is the protein family that this protein belongs to?
Belongs to the polyadenylate-binding protein type-1 family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with polysomes.
Protein: REV_HV1YB
Sequence: MAGRSGVNDEDLLKAVKIIKILYQSNPYPDSSQGTRQARRNRRRRWRARQRQIRAISERILGAYLGGPQEPVDLPLPPLGRLTLDHKEDSGDPGTESQQGTATTE
What is the function of this protein?
Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells.  These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts).  This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.  Rev itself is translated from a fully spliced mRNA that readily exits the nucleus.  Rev's nuclear localization signal (NLS) binds directly to KPNB1/Importin beta-1 without previous binding to KPNA1/Importin alpha-1.  KPNB1 binds to the GDP bound form of RAN (Ran-GDP) and targets Rev to the nucleus.  In the nucleus, the conversion from Ran-GDP to Ran-GTP dissociates Rev from KPNB1 and allows Rev's binding to the RRE in viral pre-mRNAs.  Rev multimerization on the RRE via cooperative assembly exposes its nuclear export signal (NES) to the surface.  Rev can then form a complex with XPO1/CRM1 and Ran-GTP, leading to nuclear export of the complex.  Conversion from Ran-GTP to Ran-GDP mediates dissociation of the Rev/RRE/XPO1/RAN complex, so that Rev can return to the nucleus for a subsequent round of export.  Beside KPNB1, also seems to interact with TNPO1/Transportin-1, RANBP5/IPO5 and IPO7/RANBP7 for nuclear import.  The nucleoporin-like HRB/RIP is an essential cofactor that probably indirectly interacts with Rev to release HIV RNAs from the perinuclear region to the cytoplasm.
What are the official names of this protein?
Protein Rev, ART/TRS, Anti-repression transactivator, Regulator of expression of viral proteins.
What is the protein family that this protein belongs to?
Belongs to the HIV-1 REV protein family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Note=The presence of both nuclear import and nuclear export signals leads to continuous shuttling between the nucleus and cytoplasm.
Protein: COXX_LISMC
Sequence: MNQIEKTGELSASRFTVRDFTELVKIGIVNSNTITAFTGMWLAFQLNGISFIQNVDVIFFTIVGSALIVAASGAFNNVIDRDIDGIMERTKNRPTMTGKISGKRALMVALVLGVVGTIMLFMTTWQAGVLGVIGVFLYVVVYSLYAKRKLVSNTVIGSFSGAVPPLIGWFAVEPSFSIVPIMLFLVMFCWQPPHFYAIAIKRKEEYAAAGIPMLPVVKGIERTKKSMFFWVILLTILPFFMFELGIVYVVLATLLNIGWLALSIYGFKMEDSIKWAKWMFVYSLNYMTILFVAMVVISIFL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: INSC1_ECOLI
Sequence: MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE
What is the function of this protein?
Involved in the transposition of the insertion sequence IS2.
What are the official names of this protein?
Transposase InsC for insertion element IS2A.
What is the protein family that this protein belongs to?
Belongs to the transposase 8 family.