PharMolix/UniProtQA huggingface dataset:
Protein: PAGL1_LACP3
Sequence: MDDRKFSVLIAGGGSTYTPGIVLTLLDHIQKFPLRKLKFYDIDGERQQRVADACEILVKERAPEVEFLATTDPEEAFTDVDFVMAQIRVGKYAMRSLDEKIPLKHGVVGQETTGPGGIAYGLRSIPGVIGLVDYMEKYSPNAWMLNYSNPAAIVAEATRRLRPHSRIINICDMPIGIMDRMAQIVGLKDRNDLVFRYYGLNHFGWWTDVRDKTGKDLMPALKQYVAKNGYWLGDKDKDTEASWVSTFKKAADVYALDPSTLPNTYLKYYLYPKYVVEHSDPNYTRTDEVEAYREKHVFDECDRIIAAGTAADTHFKSDDHATYIVDLCTAIAYDTKQRMLAIVPNDGAIENIDPEAMVEVPCLFGANGAERLAMGKAATFQKGLITEQNCVEKLTVDAFEQQSYTKLWEAMSLCKIVPDASVAKEILDEMVVANKDYWPELK
What is the function of this protein?
Is probably involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS).  Hydrolyzes a wide variety of 6-phospho-alpha-D-glucosides including the five isomeric derivatives of sucrose, i. e.  trehalulose-6'-phosphate, turanose-6'-phosphate, maltulose-6'-phosphate, leucrose-6'-phosphate, and palatinose-6'-phosphate, but is not active on sucrose-6-phosphate.  Can also hydrolyze maltose-6'-phosphate and methyl-alpha-glucose-6-phosphate, and poorly, trehalose-6-phosphate.  Fails to hydrolyze beta-O-linked phosphorylated disaccharides such as cellobiose-6'-phosphate and gentiobiose-6'-phosphate.  Does not seem to be involved in maltose catabolism.
What are the official names of this protein?
6-phospho-alpha-glucosidase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 4 family.
Protein: KR121_HUMAN
Sequence: MCHTSCSSGCQPACCAPSPCQASCYIPVGCQSSVCVPVSFKPAVCVPVRCQSSVCVPVSCRPVVYAAPSCQSSGCCQPSCTSVLCRPISCSTPSCC
What is the function of this protein?
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins.  The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
What are the official names of this protein?
Keratin-associated protein 12-1, High sulfur keratin-associated protein 12.1, Keratin-associated protein 12.1.
What is the protein family that this protein belongs to?
Belongs to the KRTAP type 12 family.
Protein: GCDH_HUMAN
Sequence: MALRGVSVRLLSRGPGLHVLRTWVSSAAQTEKGGRTQSQLAKSSRPEFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTASK
What is the function of this protein?
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism.  It uses electron transfer flavoprotein as its electron acceptor.  Isoform Short is inactive.
What are the official names of this protein?
Glutaryl-CoA dehydrogenase, mitochondrial, GCD.
What is the protein family that this protein belongs to?
Belongs to the acyl-CoA dehydrogenase family.
Protein: RL25_FRATF
Sequence: MANFVLKAEKREDLGTGASRRLRRAGKIPAVIYGGEKEAVSVLLDHDKVLHSTEDKEFFSSEITLDIDGKQEKVIIKALQRHPYKVKLIHADFMRV
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family.
Protein: CHL1_ASHGO
Sequence: MGRCEFYHPFTPYRIQLELMQQIYGLLESGKKMGIFESPTGTGKTLSLICSTFTWLREHKAGYLQGSTGAQDSEEDSEDEPAWVKENYEQSVLADVTASMRAYEQRLAAVDTDLLVKGAAKRQRVEVAVERPDDGAEFLPDAYHSDVEERPSHAGGRGQLRKQLDADIKRLLRKLDEPDAADKSRLAANPLKVYFASRTHTQLGQFAAQLRLPQFPPSLAGLEQERVKFLPLGSRKQLCIHKKVSKVKSDGINEACMDAVSKSECSFFSAAREPDIIRQFQDQAFSTIQDIEDLVGIGNTLHACPYYSSRELIEGAEVITLPYQHLLLENARKTMGIDLRDSIIVIDEAHNLIDTINSIHSASISLTELRQCKLALQAYLAKFKTRLNSGNRVNLLKLIKMVDVLSQFIETQYKNGKRINDPNDIFMGTSMDVVNIHKLEKYMKTSKVAYKIDKYIQATTSNDLQDRGSRDIKQPILFKVASFLKTLANPSEEGQFFFENGHVLKYMLLEPSEVLKSIVTEAKCVILAGGTMEPVNDFFTQLVPYLAPTDVTTYSCGHVIPDDNLNAFIVSENFEFTFANREDIALIERLFHFIYQLASRVPFGMVVFFSSYKYIDFVVKTWTDRGLLSRLDAIKRIYHETSDGADVLKGYSETIQSEKKGAILLAVVGGRLSEGINFENELARAVVLVGLPFPNMFSGEMIVKQQHIKEKVIRNGGTQEDVNKAVREFYENICMKAVNQSVGRAIRHASDFANVYLIDKRYSGPRIQQKLSDWVRKRIQSASNIPKILSDTEAFFSGKGL
What is the function of this protein?
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity).  May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity).  Has a specific role in chromosome segregation during meiosis II (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase CHL1, Chromosome loss protein 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMK_METBU
Sequence: MKIALLSRSRKLYSSRRLIEAAEERGHEIQVIDVLRAYMNITSHKPSIHYKGEELEGFDVVIPRIGASVTFYGASVLRQFEMMGVYPLNESVAITRSRDKLRSLQLLSRKGIGMPVTGYASKPDDIKDVIKMVGGAPLVVKLLEGTQGIGVVLAETQKAAESVIEGFMGVKANILVQEYIKEANGADIRCFVIGGKVVASMKRQAPNGEFRSNLHRGGSAEVIRITPEERSTAVSAAKIMGLNVAGVDLLRSNHGPVVMEVNSSPGLRGIETATGKDIAGMIIEYIEKSGKVGKTKTRGKG
What are the official names of this protein?
Probable alpha-L-glutamate ligase.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: PUR5_AGRFC
Sequence: MSQSGKNGLTYSDAGVDIDAGNLMVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFTDPVLVAANDGVGTKLKIAIDADYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVSGIAAGCRESGCALIGGETAEMPGMYSDGDYDLAGFAVGAAERGQLLPAGDIAEGDVILGLSSSGVHSNGFSLVRKIVSLSGLEWSAPAPFADGKKLGEALLTPTRIYVKPLLKAIRETGALKALAHITGGGFPENIPRVLPKHLAAEIDLAAIKVPAVFSWLAKTGGVEAHEMLRTFNCGVGMIVVVSAENATKVTEALTAEGETVFPLGRMVAREDGAHGTIYKGTLGL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCY_STRPS
Sequence: MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAATYMALKNQLGVEEVEALLALLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAIAAIPEVREKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKENIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAEAEKRM
What are the official names of this protein?
Cytidylate kinase, CK, Cytidine monophosphate kinase, CMP kinase.
What is the protein family that this protein belongs to?
Belongs to the cytidylate kinase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UNG_STRP1
Sequence: MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
What is the function of this protein?
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
What are the official names of this protein?
Uracil-DNA glycosylase, UDG.
What is the protein family that this protein belongs to?
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPF_PELTS
Sequence: MHFTKAHGLGNDFILVDCFKEKVNPEDFPGLAVKMCDRHFGVGADGLVLLLPSPSADVSMRIFNPDGSEAEMCGNAIRCVAKYLYERGMVKADRIRVETLAGVMIPELLVEEGRVRLVRVDMGEPRLERSEIPMEGPPGRVLGEPLETGGAVYRITAVSMGNPHCVIFVQDLDAVPFQTAGPLIETHPAFPRRTNVEFIQVLTPEEIKMRVWERGAGETMACGTGACAAVVAGVLNGYTGRRVTVHLKAGDLFIEWPEGKHVYMSGPAEEVFSGEYPYRT
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLP2R_RAT
Sequence: MRPQPSPAVPSRCREAPVPRVRAQPVGIPEAQGPVPLHSQQMRLLWGPGRPFLALLLLVSIKQVTGSLLKETTQKWANYKEKCLEDLHNRLSGIFCNGTFDRYVCWPHSYPGNVSVPCPSYLPWWNAESPGRAYRHCLAQGTWQTRENTTDIWQDESECSENHSFRQNVDHYALLYTLQLMYTVGYSVSLISLFLALTLFLFLRKLHCTRNYIHMNLFASFILKVLAVLVKDMVSHNSYSKRPDDESGWMSYLSETSVSCRSVQVLLHYFVGTNHLWLLVEGLYLHTLLEPTVFPERRLWPKYLVVGWAFPMLFVIPWGFARAHLENTRCWATNGNLKIWWIIRGPMLLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLLLIPLLGVHEVLFTFFPDDQVQGFSKRIRLFIQLTLSSVHGFLVALQYGFANGEVKAELRKSWGRFLLARHWGCRTCVLGKNFRFLGKCSKKLSEGDGSETLQKLRFSTCSSHLASETLGDVGVQPHRGRGAWPRGSSLSESSEGDFTLANTMEEILEESEI
What is the function of this protein?
This is a receptor for glucagon-like peptide 2.  The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
What are the official names of this protein?
Glucagon-like peptide 2 receptor, GLP-2 receptor, GLP-2-R, GLP-2R.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: A49_VAR67
Sequence: MDEGYYSGNLESVLGYVSDMHTKLASITQLVIAKIETIDNDILNNDIVNFIMCRSNLNNPFISFLDTVYTIIDQEIYQNELINSLDDNKIIDCIVNKFMSFYKDNLENIVDAIITLKYIMNNPDFKTTYAEVLGSRIADIDIKQVIRENILQLSNDIRERYL
What are the official names of this protein?
Protein A49.
What is the protein family that this protein belongs to?
Belongs to the poxviridae A49 protein family.
Protein: PURA_CLOBL
Sequence: MSAFIVLGAQWGDEGKGKMTDYLAENADVVVRFQGGNNAGHTVVVGEKEYKLHLIPSGILYNDKLNVIGNGVVLDPKALFEEINYLESLGVEITPDRLIISDRAHVIMPYHRVLDGIKERARGNKDIGTTGKGIGPSYTDKMERSGIRVCDLIHKEVFEENLKETLEVKNKIITEVFGGEALDYNEIYNEYLGYAEKLRPFVKDISVIVNKKIKDGKEVLFEGAQGTLLDIDYGTYPYVTSSSTIAGGVCIGAGVGPTAITNAVGIAKAYTTRVGKGPFPTELLDSTGDWVREKGHEFGVTTGRARRCGWLDLVILKTSARISGLTSFAVTKIDTLAGLDTLKVCTGYRLNGEIIDYVPASLEDLAKCEPIYEEFEGWDDSIANARCYEDLPENAIKYLKKIEDFTETKVSIVSVGPKRDQTMMISEI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR5_PSEAE
Sequence: MSSKQPSLSYKDAGVDIDAGEALVERIKGVAKRTARPEVMGGLGGFGALCEIPAGYKQPVLVSGTDGVGTKLRLALNLNKHDSIGQDLVAMCVNDLVVCGAEPLFFLDYYATGKLNVDVAATVVTGIGAGCELAGCSLVGGETAEMPGMYEGEDYDLAGFCVGVVEKAEIIDGSRVQAGDALIALPSSGPHSNGYSLIRKIIEVSGADIAQVQLDGKPLADLLMAPTRIYVKPLLQLIKQTGAVKAMAHITGGGLLDNIPRVLPDNAQAVIDVASWNRPAVFDWLQEQGNVDETEMHRVLNCGVGMVICVAQSDAEKALEVLRAAGEQPWQIGRIETCGADAERVVLNNLKNH
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU1M_PODAN
Sequence: MYYSIIISLIEVVLVLVPALLGIAYVTIAERKTMASMQRRLGPNFVGYYGLLQAFADALKLLLKEYVAPTQANIILFFLGPVITLIFSLLGYAVIPYGPSLAINDFSLGIYYILAVSSLATYGILLAGWSANSKYAFLGSLRSTAQLISYELVLSSAILLVIMLTGSLNLSVNIESQRAIWNIFPLLPVFIIFFIGSVAETNRAPFDLAEAESELVSGFMTEHAAVVFVFFFLAEYGSIVLMCILTSILFLGGYLSINSLDVFNFFYSILFNIGFIDLNFFNIFYYFYKEIFVNNSIIEGLIYGLTIGLKSSILIFLFIWVRASFPRIRFDQLMAFCWTVLLPLLFALIVLLPCILYSYNILPVNVL
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 1, NADH dehydrogenase subunit 1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CYB_MYOVI
Sequence: MTNIRKSHPLVKIINSSFIDLPTPSNISSWWNFGSLLGICLMLQILTGLFLAMHYTSDTTTAFYSVTHICRDVNYGWTLRYLHANGASMFFICLYLHVGRGLYYGSYTYTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFALHFLLPFIIAAMVMVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGLLLMITVLLTLVLFFPDLLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILIIIPLLHTSKQRSMTFRPLSQCLFWLLTADLLTLTWIGGQPVENPYIIIGQLASILYFTTIIVLMPLTGLMENYLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ATPA_BDEBA
Sequence: METQIRADEISRVLKEQINQYNKKIEVSETGSVLSVGDGVARIYGLENAMAGELVEFPGEVFGMVLNLEEGYVGAVLFGEDRHIKEGDVVKRTKKIVSVPVGEALLGRVVDALGNPIDGRGAINTPHSRIVETKAPGIVYRHPVEEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIAVDTIINQKGLNVQCFYVAIGQKQSTVALVVEKLRAAGALEYTTVIAANASDPAPLQYLAAYSGTAMAEYFRDTGRHALIVYDDLTKQAQAYRQLSLLLRRPPGREAYPGDVFYCHSRLLERASKLSADKGGGSLTALPIIETQAGDISAYIPTNVISITDGQIFLESDLFYKGVRPAISVGKSVSRVGGAAQIKAMKQVAGSLKLELAQFRSMEAFAAFASDLDKASQQQLARGRRLIEVLKQPQYSPVKVEEQIIMIFAAGNAFVDQYPETDVKRYEKEMIEFLKNKHSDIIKTISEKKAIADDTKKALLAALEEFKAIFQPSNK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: HTHAR_MYCTU
Sequence: MSTYRSPDRAWQALADGTRRAIVERLAHGPLAVGELARDLPVSRPAVSQHLKVLKTARLVCDRPAGTRRVYQLDPTGLAALRTDLDRFWTRALTGYAQLIDSEGDDT
What is the function of this protein?
Involved in the regulation of lipid metabolism and hypoxic response.  Positively regulates transcription of various genes, such as phoP, groEL2 and dosR.  Negatively regulates its own transcription.  Acts by binding to a specific palindromic sequence motif in promoter regions.
What are the official names of this protein?
HTH-type transcriptional regulator Rv2034.
Protein: STRA6_PONAB
Sequence: MSSQPAGNQTSPGPTEDYSYGSWYIDEPQGGEELQPEGEVPSCHTSIPPSLYHACLASLSILVLLLLAMLVRRRQLWPDCVRGRPGLPSPVDFLAGDRPQAVPAAVFVVLFSSLCLLLPDEDPLPFLTLASAPSQDGKTEAPRGAWKILGLFYYAALCYPLAACATAGHTAAHLLGSTLSWAHLGVQVWQRAECPQVPKIYKYYSLLASLPLLLGLGFLSLWYPVQLVRSFSCRTGAGSKGLQSSYSEEYLRNLLCRKKLGSSSHTSKHGFLSWAWVCLRHCIYTPQPGFRLPLKLVLSATLTGTAIYQVALLLLVGMVPNIQKVRAGVTTDVSYLLAGFGIVLSEDKQEVVELVKHHLWALEVCYISALVLSCSLTFLVLMRSLVTHRTNLRALHRGAALDSSPLHRSPHPSRRAIFCWMSFSAYQTAFICLGLLVQQIIFFLGTTALAFLVLMPVLHGRNLLLFRSLESSWPFWLTLALAVILQSMAAHWVFLETHDGHPQLTNRRVLYAATFLLFPLNVLVGAMVATWRVLLSALYNAIHLGQMDLSLLPPRAATLDPGYYTYRNFLKIEVSQSHPAMTAFCSLLLQARSLLPRTMAAPQDSLRPGEEDEGMQLLQTKDSMAKGARPRANRGRARWGLAYTLLHNPTLQVFRKTALLGANGAQP
What is the function of this protein?
Functions as retinol transporter.  Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1.  Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A.  Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin.  Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid.  STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency.  Does not transport retinoic acid.
What are the official names of this protein?
Receptor for retinol uptake STRA6, Retinol-binding protein receptor STRA6, Stimulated by retinoic acid gene 6 protein homolog.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=In the retinal pigment epithelium localizes to the basolateral membrane.
Protein: RS11_PSEPG
Sequence: MAKPAARPRKKIKKTVVDGIAHIHASFNNTIVTITDRQGNALSWATSGGSGFRGSRKSTPFAAQIAAERAGQAALEYGLKNLDVNVKGPGPGRESAVRALNSCGYKIASITDVTPIPHNGCRPPKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: CARA_PSESM
Sequence: MTKPAILALADGSIFRGEAIGADGQTVGEVVFNTAMTGYQEILTDPSYAQQIVTLTYPHIGNTGTTPEDAESDRVWSAGLVIRDLPLVASNWRNKMSLGDYLKANNVVAIAGIDTRRLTRILREKGAQNGCIMAGDNISEEAAIAAARGFPGLKGMDLAKEVSTKDTYEWRHSVWNLQTDSHPEIAASELPYHVVAYDYGVKVNILRMLVERGCRVTVVPAQTPASEVLAYKPDGVFLSNGPGDPEPCDYAIKAIKQVLETEVPVFGICLGHQLLALAAGAKTVKMGHGHHGANHPVQDLDTGVVMITSQNHGFAVDESTLPGNVRAIHKSLFDGTLQGIELTDKSAFSFQGHPEASPGPNDVAPLFDRFIDAMAKRR
What are the official names of this protein?
Carbamoyl-phosphate synthase small chain, Carbamoyl-phosphate synthetase glutamine chain.
What is the protein family that this protein belongs to?
Belongs to the CarA family.
Protein: S45A1_MOUSE
Sequence: MIPPASSTPPGEAVIPSVAPQDFWRSPISSYSGSVTGHISHRANNFKRHPKRRKYIRPSPPPPPNTPCPIELVDFGDLHPQRSFWELLFNGCILFGIEFSYAMETAYVTPVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGLSLLLNGRDIGMALADTATNHKWGILLTVCGVVLMDFSADSADNPSHAYMMDVCGPVDQDRGLNIHALMAGLGGGFGYVVGGIHWDKTSFGRALGGQLRVIYVFTAITLSVTTVLTLISIPERPLRPLGEKRTAMKSPSLPLPPSPPVLLEEGAGDALPSTTATSLYASFSSPISPPSPLTPKYGSFISRDSSLTGINEFASSFGTSNIDSVLIDCFTAGHDNYLALPSSVPRQAISVSFPRAPDGFYCQERGLERREGPLTLGSDGDVLRVGSLDTSKPRASGILKRPQTLALPDVAGGNGPETSRRRNVTFSQQVANILLNGVKYESELTGSSEQSEQPLSLRHLCSTIYNMPKALRNLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEKLEECLSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCTTYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVSFLGCLYSSLCVTYEIPSVDAADEERQPLLLNV
What is the function of this protein?
Proton-associated glucose transporter in the brain.
What are the official names of this protein?
Proton-associated sugar transporter A, PAST-A, Deleted in neuroblastoma 5 protein homolog, DNb-5 homolog, Solute carrier family 45 member 1.
What is the protein family that this protein belongs to?
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: RASA3_BOVIN
Sequence: MAVEEEGLRVFQSVKIKIGEAKNLPTYPGPNKMRDCYCTVNLDQEEVFRTKVVEKSLCPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIKKEDLQKYHNRDTWFQLQHVDADSEVQGKVHLELRLSEVITDSGVVCHKLATRILECQGLPIVNGQCDPYATVTLAGPCRSEAKKTKVKKKTNNPQFDEVFYFEVTRPCSYSRKSHFDFEDEDVDKLEIRVDLWNASNLKFGDEFLGELRVPLKVLRQSSPHEAWYFLQPRDNGSKSLKPGDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAIPLVRLFLHYGRVVPFISAIASAEVRRTQDPNTIFRGNSLTSKCIDETMKLAGMQYLHVTLKPTIEEICQSHKSCEIDPVRLKDGESLESNMENLRQFVDRVFSVITKSGVSCPTVMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLVSKTIQTLGSLSKSKSASFKESYMAAFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVQQPILLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKGDPPLYSIPIENILAVEPLEEESFKMKNMFQVIQPERALYIQANNCVEAKAWIDILTKVSQCNQKRLAVYHPSAYLNGHWLCCRASSDTAAGCSPCTGGLPANIQLDIDGDRETERIYSLSSSYMSKLETMQEACGSRSVYDGPEQEEYSTFIIDDPQETYKTLKQVVAGVGALEQEHAQYKRDKFRRTKYGSQEHPIGDKSFQSYIRQQSETPAHSM
What is the function of this protein?
Inhibitory regulator of the Ras-cyclic AMP pathway.  May bind inositol tetrakisphosphate (IP4).
What are the official names of this protein?
Ras GTPase-activating protein 3, GAP1(IP4BP), Ins P4-binding protein.
Protein: MINC_SHEPC
Sequence: MSKPSLELKGASFTLSVLHINSSDLNAVMAELDSKLAQAPQFFLGAPLVVNLSAIQHNDFNLHGLKELLLSRQLVIVGITGATTVLSKQAKDLGLAIVKAGKQSTTPPPAPRQTKIVKQNIRSGQQVYAKNGDLIIFGAVGNGAEVIADGSIHIYGALRGKAMAGAAGDPTAVIIAHSLEAELVSIAGQYWLAENLQQHSSDKSGCIRLNGESLMVESLPL
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: Y3379_CLOBH
Sequence: MRYLVDTHTHTIVSGHAYTTFLENVQEASNIGLKVLGTTDHGPSMPGGPNLFYFNNFKVMPRKLKGVTLLHGCEANIIDFKGMLDIPDFTQKKLDVIIASLHDVCIRPGSVEENTEALINVMENPYVDILGHIGNPSFPINEEVVVKKAKEKNVLIEINNGSFVSRKGSEETCKKVANLCKKHKVNIIVGSDSHVCFQIGRFPKADNMLKEIGMPEELIINNEENKILKYLKNKGKLKDLNLD
What are the official names of this protein?
Probable phosphatase CBO3379/CLC_3322.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: YTRC_BACSU
Sequence: MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCLDRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIFQTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAAGALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLSNLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRPVQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV
What is the function of this protein?
Part of the ABC transporter complex YtrBCDEF that plays a role in acetoin utilization during stationary phase and sporulation.
What are the official names of this protein?
Probable ABC transporter permease YtrC.
What is the protein family that this protein belongs to?
Belongs to the ABC-5 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNC_ACIBS
Sequence: MTKHQFKLSDPRLLSRIGYQFKQPELLQLALTHRSVSHKYNYERLEFLGDSLLGMIIANYLYHAYPHENEGRLTRMRATLVRQEALGKIATDLQLSRCLILSTGELKSGGHHRESILADTVEAIIGAIYLDSSDLNLLKDIVLKWYTPYLDHIEPTDQLKDPKSRLQEYLQARKKPLPVYEVVDIQGDAPHQHFKVECLVDGLSKIHGEGASRRFAEQAAAAEILKLLEQ
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.