PharMolix/UniProtQA huggingface dataset:
Protein: TSAC_SALCH
Sequence: MNNNLPTGSIAAAVDLLNKENVIAYPTEAVFGVGCDPDSETAVTRLLALKQRPVDKGLILIAASFEQLKPYIDDSILTAAQRKAVFDCWPGPVTFVFPAPATTPRWLTGRFDSLAVRVTNHPLVVALCNAYGKPLVSTSANLSGLPPCRTVEEVRAQFGDDFPVVEGATGGRLNPSEIRDALTGELFRQG
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UVRC_BRADU
Sequence: MVHDSTDDPDDTRVRKSRRGTALDAPPQETAPPDLDPATTGGDDEDDALLPDILEESGAVGEEPLASGHEAIERAVRLAPTSPGVYRMLNANADVLYVGKAKNVKKRLSNYARQSAPQPARILRMIAATVTVEIVSTNTETEALLLEANLIKQLRPRFNVQLRDDKSFPYILITGDHWAPQILKHRGAQTRPGRYFGPFASAGAVNRTITALQRAFLIRSCTDSFFESRSRPCLLYQIRRCAGPCTREIDFPGYTTLVREATDFLSGKSHAVKQELAGEMEKAANELEFETAALYRDRLAALSAIQSQQGINPRTVEEADVFAIHQEGGFSCVEVFFFRTGQNWGNRAYFPRAEKTFTPEEVLGSFLAQFYDDKPPPKNILLSHEIEESELLANALSIKAGHKIEVTAPKRGEKKELVAHALTNAREALGRKLADTATQGRLLDAMATTLSLPHAPKRIEVYDNSHIQGTNAVGAMIVAGPDGFVKNQYRKFNIKSEGLTPGDDYGMMREVLERRFKRLINPPEEGAKVKDDDFPQWPDLVIIDGGRGQLNAVREIFANLGLTQVSLMSVAKGPDRDAGRETLFMPEREAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIGPSRKRALLHHFGTLKEIERASIADLGKVPGVSAESARRIFEYFHPQPG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPF_AERS4
Sequence: MLIDFSKMHGLGNDFMVVDGVTQKVFFSNDVIKKLADRHFGIGFDQLLLVEPPYDPELDFHYRIFNADGSEVEQCGNGARCFARFVRLKGLINRDRIAVSTARGRISLQLEGENQVTVNMGVPQFEPGKIPFRAQKAEKTYLLRAQEHTVMCGVVSMGNPHCVIEVPSVADAPVETLGAIMERHERFPERVNVGFMEMVNATEIRLRVFERGVGETLACGTGACAAAVIGISQGKLKERVTVSLPGGKLTIAWKGPGQPVYMTGPAEHVFDGQIEL
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYM_SACS2
Sequence: MKVLVTAAWPYVNSVPHLGNLIGSILSADVFARYARLRYGKENVLFVSGSDEHGTPIEIEAIKRKVNPKELTDQAHEYDRHLFLNVWKISFDNYTRTESEIHKKFVREFLLKLTKYIKVSEDEIPYCENDKLYLPDRFVKGTCPYCGFEDARGDQCDNCGKLLTPSLLVNPKCSICGKTPVFKKTKHWFFDLSEFNDKIRGWISSSNEMPDNVKSVALSWVGEGLKPRSITRDNKWGIPAPFEGAQDKSIYVWFEALLGYISAVIEYFERKGDQEKWKEYWFGPNIKSYYFIGKDNIPFHAVILPAMLMASEEEYHLPDVIAATEYLLYEGQKFSKSRKIGVWIDEAPELMDVEYWRFVLIRLRPEEKDTNFTWRETVRIVNTELNDDIGNYVNRVLSMVNRYYSGIVPEFKIDILDDNDRKIISLINETPKVVGDLFEKGKLKAGTEEMLKFVRECNAYLNMKAPWDLYKSGKEIELKNTLYIGTNSVKTIAILLYPLMPSHAQKIYEMLNMGNIENEKWDVASTLSVNPGHKIGKVNVLFKKLEPEFESKIKDKLEKIRKDIEKIRPTLLK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACCA_SINMW
Sequence: MHNYLDFEKPISDLEGKILELKKLASEDESVNTSDEIARLEGRVRDAMVEIYSKLSPWQKTQVARHPSRPHFLDYASRLFTEFTPLAGDRNFANDDAIQAGLARFRGAPVAVIGQEKGNDTKSRIKHNFGSPRPEGYRKATRIMEMADRFGLPLITLVDTAGAYPGVNAEERGQAEAIARSTEMCLNVKVPIVTVVIGEGGSGGAIAIATGNRVYMLEHAIYSVISPEGAASILWRDSTRAKEAASNMKITAEDLKSLGVIDGIIPEPIGGGHRDPDAVISRTEAVIGDALKELSARSGDELRSDRRQKYLNIGRNL
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MT3B_ORYSI
Sequence: MSDKCGHCDCADKSQCVKKGTSYGVVIVDAEKSHFEMAEEVGYEENDGKCKCTTGCSCAGCNCGK
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein-like protein 3B, Class I metallothionein-like protein 3B, OsMT-I-3b.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 15 family.
Protein: SLMA_PHOLL
Sequence: MAENENTKKRNRREEILQALAHMLQSSDGSHRITTAKLAANVGVSEAALYRHFPSKTRMFDSLIEFIEDSLISRINLILQDEKDTITRIRLILVLILGFSEKNPGLTRIMTGHALMFEQNRLQGRINQLFERIEVQIRQVLKEKKLRDGQGFSYDESLLASQLLAFCEGMLSRFVRSEFHYRPTQEFEARWPLLLAQLQ
What is the function of this protein?
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid.  Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers.  SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
What are the official names of this protein?
Nucleoid occlusion factor SlmA.
What is the protein family that this protein belongs to?
Belongs to the nucleoid occlusion factor SlmA family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: ACCD_MARPO
Sequence: MSLMNWFEDKRRFGGLIGAFIEKATKGYIFSEREKDRYIKIDTTKGLWTRCDNCENMLYVRFLRQNKRICEECGYHLQMSSTERIELLIDRGTWYPMDEDMTARDVLKFSDEDSYKNRIAFYQKRTGLTDAIQTGIGQLNGIPIALGVMDFQFMGGSMGSVVGEKITRLIEYATRASMPLIIVCSSGGARMQEGTLSLMQMAKISSVLQIHQAQKRLLYIAILTYPTTGGVTASFGMLGDIIIAEPKAYIAFAGKRVIEQTLRQKIPDGFQVAESLFDHGLLDLIVPRNLLKGVLSEIFELYNAAPCKKFQNSFFK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: UPPP_BORBR
Sequence: MTDSTLHLLKAFFLGIVEGLTEFIPVSSTGHLIVIGDWINFASSSGKVFEVVIQFGSILAVMWIFRARLWQLIRGTLTGVRQEVNFTRNLLLAFLPAAVIGAIFIKSIKQVFYHPGVVAVTLVVGGFIMLWVERRAPHTPGDAPGAADDTASDERATAHTLEQISAKQALGVGVAQCVAMIPGVSRSGATIIGGMIAGIQRKTATEFSFFLAMPTMLGAAVYDLYRNIGLLSQHDMSAIAVGFVAAFLSALVVVRAVLRFVANHTYRVFAWYRIALGLVVAAWIYAK
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TT21B_HUMAN
Sequence: MDSQELKTLINYYCQERYFHHVLLVASEGIKRYGSDPVFRFYHAYGTLMEGKTQEALREFEAIKNKQDVSLCSLLALIYAHKMSPNPDREAILESDARVKEQRKGAGEKALYHAGLFLWHIGRHDKAREYIDRMIKISDGSKQGHVLKAWLDITRGKEPYTKKALKYFEEGLQDGNDTFALLGKAQCLEMRQNYSGALETVNQIIVNFPSFLPAFVKKMKLQLALQDWDQTVETAQRLLLQDSQNVEALRMQALYYVCREGDIEKASTKLENLGNTLDAMEPQNAQLFYNITLAFSRTCGRSQLILQKIQTLLERAFSLNPQQSEFATELGYQMILQGRVKEALKWYKTAMTLDETSVSALVGFIQCQLIEGQLQDADQQLEFLNEIQQSIGKSAELIYLHAVLAMKKNKRQEEVINLLNDVLDTHFSQLEGLPLGIQYFEKLNPDFLLEIVMEYLSFCPMQPASPGQPLCPLLRRCISVLETVVRTVPGLLQTVFLIAKVKYLSGDIEAAFNNLQHCLEHNPSYADAHLLLAQVYLSQEKVKLCSQSLELCLSYDFKVRDYPLYHLIKAQSQKKMGEIADAIKTLHMAMSLPGMKRIGASTKSKDRKTEVDTSHRLSIFLELIDVHRLNGEQHEATKVLQDAIHEFSGTSEEVRVTIANADLALAQGDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQKNYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVLLAKVYSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSVAQRDYEKAIKFYREALVHCETDNKIMLELARLYLAQDDPDSCLRQCALLLQSDQDNEAATMMMADLMFRKQDYEQAVFHLQQLLERKPDNYMTLSRLIDLLRRCGKLEDVPRFFSMAEKRNSRAKLEPGFQYCKGLYLWYTGEPNDALRHFNKARKDRDWGQNALYNMIEICLNPDNETVGGEVFENLDGDLGNSTEKQESVQLAVRTAEKLLKELKPQTVQGHVQLRIMENYCLMATKQKSNVEQALNTFTEIAASEKEHIPALLGMATAYMILKQTPRARNQLKRIAKMNWNAIDAEEFEKSWLLLADIYIQSAKYDMAEDLLKRCLRHNRSCCKAYEYMGYIMEKEQAYTDAALNYEMAWKYSNRTNPAVGYKLAFNYLKAKRYVDSIDICHQVLEAHPTYPKIRKDILDKARASLRP
What is the function of this protein?
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs).  Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (PubMed:27932497).  Negatively modulates the SHH signal transduction (By similarity).
What are the official names of this protein?
Tetratricopeptide repeat protein 21B, TPR repeat protein 21B, Intraflagellar transport 139 homolog.
What is the protein family that this protein belongs to?
Belongs to the TTC21 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: IF1C_STAPU
Sequence: MRKQNLIEMEGIVTESLPNAMFRVCLDNGCQVLAHISGKIRKNYIRILLGDRVKVELSPYDLTKGRITYRLRTRSPS
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MFL1_ARATH
Sequence: MEARLSETLGLPSPNLNHCHFPNEFNSLFTHFSDLTSVQSPIVRNPKLKTKSSQKPPKFSANFRRSDPPFASTSISDPTHEKPGPEFLKWIKPASRSSPRIQTLIKQLSVWERAIIGAGAGGLAGAFTYVTLLPLDAIKTKLQTKGASQVYSNTFDAIVKTFQAKGILGFYSGVSAVIVGSTFSSAVYFGTCEFGKSLLSKFPDFPTVLIPPTAGAMGNIISSAIMVPKELITQRMQAGASGRSYQVLLKILEKDGILGLYAGYSATLLRNLPAGVLSYSSFEYLKAAVLEKTKQSHLEPLQSVCCGALAGAISASITTPLDVVKTRLMTQIHVEAVDKLGGAMYTGVAGTVKQILTEEGWVGFTRGMGPRVVHSACFSAIGYFAFETARLTILNEYLKRKEESEANVAADS
What is the function of this protein?
Probably involved in iron transport into chloroplasts.
What are the official names of this protein?
Protein MITOFERRINLIKE 1, chloroplastic, AtMFL1.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Plastid, chloroplast inner membrane; Multi-pass membrane protein.
Protein: RLMH_SOLM1
Sequence: MKPLRLIAVGQVRTPYFREACAHYLTAVRRYLPAEEILARDGKSADPARRKAEEAKAVLAALAPRDFVVVLDEHGPSLPSTELAALLKKRIEDPGRAPAFVIGGPFGLDKAVLDRADRLLALGPGTLPHELARVVLYEQLYRAASINAGAPYHH
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HACD3_HUMAN
Sequence: MENQVLTPHVYWAQRHRELYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEFHLEFLDLVKPEPVYKLTQRQVNITVQKKVSQWWERLTKQEKRPLFLAPDFDRWLDESDAEMELRAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIGVTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKKIH
What is the function of this protein?
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle.  This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle.  This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation.  Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.  May be involved in Rac1-signaling pathways leading to the modulation of gene expression.  Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).
What are the official names of this protein?
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3, 3-hydroxyacyl-CoA dehydratase 3, HACD3, Butyrate-induced protein 1, B-ind1, hB-ind1, Protein-tyrosine phosphatase-like A domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the very long-chain fatty acids dehydratase HACD family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GIP1L_ARATH
Sequence: MSSSDGGSSRVSIPYHLRKTLQKIREYTGKQHSDEDIFAVYKDSFNDPHETAQKLLFLDTFHEVRSKREKKKEPIVPVTQPSGRGGRRNFASSNSYQGSGRNASFKRENGANHVTRGSRTAQPATNKASNITVPNETKVSGPASIPSEVSNHKAQDDPSLISASRCSSKSDQAIEIETASKQGKNQSLPKPDVSEQSHVTFPFHLQVAKGLQNGLTFGSFDSNFVKEVSSSNGASGGYDSNFESSHGTGDDERESSPTTNGITGVASAREETSTVSEDKDYGISNSATGAEPVVHSDHIVPPVEEVPKEEALSNTETHQIAYGQEAPLSVFGLVPSLSAIGQPVNTEAAETQPGNSNSPPISLVSYPPDQSSIAAATQQTNFLRQQYPPNFFPYGYYSPYYMPPPYIHQFLSPNGIPQQSYFPQGAALTAPSHAKPVDNTENPPTTNPYLHTSPMVASSIPSTTTLNSIHSEEKASHLTESAAAWIGQGFGNLQVNPMYNLAYQGQPLGFPVVQAGHGGLMGMHQPTQPMAAASTTYQTLPPPPHTTTAMGEPIGHPHIAYQQPQAALTNWVNNY
What is the function of this protein?
May act as a transcriptional coactivator of LOB domain-containing proteins.
What are the official names of this protein?
GBF-interacting protein 1-like, Protein GIP1-like.
What is the protein family that this protein belongs to?
Belongs to the GIP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EXP10_ORYSJ
Sequence: MAPCLLLVLFLLPALATGHQHPSTLGSSALSEWRSAKASYYAADPEDAIGGACGFGDLGKHGYGMATVGLSTALFERGAACGGCYEVKCVDDLKYCLPGTSIVVTATNFCAPNFGLPADAGGVCNPPNHHFLLPIQSFEKIALWKAGVMPIQYRRVNCLRDGGVRFAVAGRSFFLTVLISNVGGAGDVRSVKIKGTESGWLSMGRNWGQIWHINSDFRGQPLSFELTSSDGKTLTNYNVVPKEWDFGKTYTGKQFLL
What is the function of this protein?
May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans.  No enzymatic activity has been found.  May be required for rapid internodal elongation in deepwater rice during submergence (By similarity).
What are the official names of this protein?
Expansin-A10, Alpha-expansin-10, OsEXP10, OsEXPA10, OsaEXPa1.28.
What is the protein family that this protein belongs to?
Belongs to the expansin family. Expansin A subfamily.
What are the subcellular locations of this protein?
Secreted, cell wall. Membrane; Peripheral membrane protein.
Protein: TOFU2_CAEEL
Sequence: MADTSPRESKLNKQDQDLHLEIDETGLACKSEVKKRWLGARGTAGLYGNGKYYYEVTITSKGLCRVGWATLGGSLNIGKGLDSFGYGGTGMKSTHKKFDDYGLPFTLNDVIGCYLDLDSRTIWWSKNGEQFPAAFSIDVKYKNSNTCLFPAVLCQNSSLSVNFGSQPFKFPPGNQFTAVSDAPNENVNWWSYEEQNSFEHVVVKLPFAVEEDVHNEFRMHTKLMLTELKRTQCKQDKDGSIRRTLQPISKTICAFLNTDGGRLFLGVNDDKVIKGISMSKNMIYHFFGSLRHMCENFKPCSPLCRIKVSILEVIPVGVIKVKLRKADLLKEEAHDFPKLACHSVGGSFCDCFLEINKAPTKQYLLIIQVSPPNPNSRTTIFQNEEGLVYRRRMASNKCVYLDDLRRMMNEKNQVFVDLPDEARAEIDSFSKFD
What are the official names of this protein?
Protein tofu-2, 21U-RNA biogenesis fouled up protein 2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN146_RAT
Sequence: MAGCGEIDHSLNMLPTNKKASETCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYVWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDSNTVNLARESSADGADSGSAHTGASVQLPVPSSTRPLTSVDGQLTSPVTPSPDAGASLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSTEETESDASSDIEDAPVVVAQHSLTQQRLLVSSANQTVAERSDRPVAGGGTMSVNVRSRRPDGQCTVTEV
What is the function of this protein?
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation.  May regulate many important biological processes, such as cell survival and DNA damage response.  Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex.  Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2.  Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation.  Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'.  May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location.  Neuroprotective protein (By similarity).  Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity).  Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity).  Does not affect PARP1 activation.  Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity).  Promotes cell survival after gamma-irradiation.  Facilitates DNA repair (By similarity).
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF146, Iduna, RING finger protein 146, RING-type E3 ubiquitin transferase RNF146.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding (By similarity).
Protein: GALE_LACHE
Sequence: MKVLVIGGAGYIGSHAVRELVKEGNDVLVLDALYTGHRKAVDPKAKFYQGDIEDTFLVSKILRDEKIDAVMHFAAYSLVPESVKKPLKYYDNNVTGMISLLQAMNDANVKYLVFSSSAATYGIPKKLPITEDTPLNPINPYGETKMMMEKIMAWADKADGIKYTALRYFNVAGASSDGSIGEDHAPETHLIPNILKSAISGDGKFTIFGDDYDTKDGTNVRDYVQVEDLIDAHILALKHMMKTNKSDVFNLGTAHGYSNLEILESAKKVTGIDIPYTMGPRRGGDPDSLVADSTKARTVLGWKPKHENVDDVIATAWKWHKSHPKGYEDK
What is the function of this protein?
Involved in the metabolism of galactose.  Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.  It also could be involved in preparation of carbohydrate residues for incorporation into complex polymers, such as exopolysaccharides.
What are the official names of this protein?
UDP-glucose 4-epimerase, Galactowaldenase, UDP-galactose 4-epimerase.
What is the protein family that this protein belongs to?
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Protein: G6PI_STRA3
Sequence: MTHITFDYSKVLGQFVGEHELDYLQPQVSAADAFLRQGTGPGSDFLGWMDLPENYDKEEFSRIQKAAEKIKSDSEVLVVIGIGGSYLGAKAAIDFLNNHFANLQTAEERKAPQILYAGNSISSTYLADLVEYVQDKEFSVNVISKSGTTTEPAIAFRVFKELLVKKYGQEEANKRIYATTDKVKGAVKVEADANNWETFVVPDNVGGRFSVLTAVGLLPIAASGADITALMEGANAARKDLSSDKISENIAYQYAAVRNVLYRKGYITEILANYEPSLQYFGEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGYRNLFETVVRVEKPRKNVTIPELTEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGGVPNMFVTLPTQDAYTLGYTIYFFELAIGLSGYLNSVNPFDQPGVEAYKRNMFALLGKPGFEELSAELNARL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMB_SERP5
Sequence: MKNNYNLRSIAAIAIGQVLDQGQSLSTVLPSLQKTISDKDRALLQELCFGTLRVLPQLEWCIQQLMAKPMTGKQRTLHYLLMVGLYQLLYTRIPAHAVLAETVEGAVALKRPQLKGLINGVLRQFQRQQEELLQRAANNDSRYLHPSWLLKRIQQAYPAQWEQIIDANNQKPPMWLRVNRLHHTREDYLQLMEQAGIAAEPHAEYRDAVRLLAPCAVTDLPGFADGWVTVQDASAQGCVDLLDPQDGEQILDLCAAPGGKTTHILEAAPKAHVMAVDIDEQRLKRVKENLQRLRLHAEVKQGDGRTPQQWCGDKQFDRILLDAPCSATGVIRRHPDIKWLRRDSDIAELAALQAEIIEAIWPHLKSGGVMVYATCSILPAENAEQVSAFLQRHADARLVETGNQQQPGRQNLPHPEDGDGFFYAKLIKM
What is the function of this protein?
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase B, 16S rRNA m5C967 methyltransferase, rRNA (cytosine-C(5)-)-methyltransferase RsmB.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPO5_DICDI
Sequence: MNNDIILVVNQIEQALSLLHDPKSNNKQREESQVFLEEIKTRANAHSYAIAIITTSNNDILKHFALHIIETLVKNRWYECNDQERELIKKEILELMRRITSNEPKFIKEKLVTILVDVIKRDWPQRWMNLLTSLIEISKISDTQTELVLSTFGLLPHDIIFDTGSTSQVLSDQRRKDLMAGINLAVTSLFEYFYQLLESKYTQYKQPTPATTTTPQQTKQVIHLINVLLTTLRSYIEWVPSKVIFDHKLDQIFCQLILDVPFRMGACENLILFLGRKGRPDERIELIQTPFNFMENFLNSIKINSDFEDDYSFHKRITQALTILGTVHLNAYDDKHKIPNNYNIYLQLMLQMVSHPSILLSSFVLPFWHTFIKVESLELSYLEEVIKQIMETMLVKFVRIGDPEKSDSEQSKYSEIDFGTSKEWSNFFGGVRTRYLDIIKLITIQRREMAYIFIATKVADVLDALKANLNVASLSHEQTLVLESHSHILDSILLNIKDFTPESSLFFNKEQQQQPNIIQLTDRVLNLLFEINSTEPNITSFQIDCLQAYILYYQTNPESIKFLLNKIVPLIPFPGLDNPNRSFQNSVLHTRRRAISSLIGISTNISHLMKPYFDILYKSVVELFQKNVVTETEKVMLFHLLIVFSNNLPSYQQTLDFYKGILTPIIEQWVSLEMSTALSSPDAFIQYLGLSIADSQNLDATLVSRRKNIQYVASTLQIFWKKSQIPTNSSDELFAPFISNGISYNGKWPISSFVKQVLPGVLSLTRTLHQLWMPEHRAKIHPSLSTIFNLDDSITAPLLGFEYHKEQKSESSNVTFLRNILDCLRDACYEIVGYGFNHSDELFSLPDLPLVLLDSVFSYLESIENRHLKLLVKHILNYLIKNCPTKLEHTIFEPILPLLFSVLFNRIKAGWELIKLRSQKGEKENEKNEIVEDKILRDVSMEFLMCCSNIITQSPNYIFSSIDVMTPMVYGISSCLMAMDTPILKKSLIVSTQLLVDHEKVNDPKFFKLIGSEMFGCCIKILIVNKFAEFSNDIQSIIRLIYMKYYQICNYPQEILLSLPNITPPILQAFNKDLISTRSEKSQKVLFKKLLQDVIGIPLNKLKKESILDLPEKLFISKISDQSNENISNISNLFN
What is the function of this protein?
Mediates the nuclear export of micro-RNA precursors, which form short hairpins.
What are the official names of this protein?
Exportin-5, Exp5.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: YCF3_BIGNA
Sequence: MPRSQKNDNFIDKTFTVVADILLKVLPTSIDEKRAFTYYRNGMSAQSEGEYAEALQNYYQALRYEIDAYDRSYMLYNIGLIHSSNGQQSKALEYYYQALDRNPRLSQALNNIATIYHYRGEQALINNQDEISKIFFDKAADYWKEAIRLSPTSYTKAKNWLSVRNK
What is the function of this protein?
Essential for the assembly of the photosystem I (PSI) complex.  May act as a chaperone-like factor to guide the assembly of the PSI subunits.
What are the official names of this protein?
Photosystem I assembly protein Ycf3.
What is the protein family that this protein belongs to?
Belongs to the Ycf3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.