PharMolix/UniProtQA huggingface dataset:
Protein: GGGPS_METHJ
Sequence: MHTKWKTWAHVTKLDPDKHLTEDEIAEIATSGTDALILSGTLNITKDNMSQLRDQVKEYGLPLVVEPAGPESVIFHGIDLLYVASVMNTSDARWIVGKHRDWAMNPDIVWEKVIPEAYIVLNPNSAVGRVTGADCGISAEEVAAYASIADHYFKFPIVYIEYSGMYGNPDIVKRAGEAIDHAVLYYGGGIDSAEKAAEMAKYADTIVVGNAVYEKGVKTLLETVQAVQ
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P).  This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Geranylgeranylglyceryl phosphate synthase, GGGP synthase, GGGPS, (S)-3-O-geranylgeranylglyceryl phosphate synthase, Phosphoglycerol geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the GGGP/HepGP synthase family. Group I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGG_ECO5E
Sequence: MKHKLQMMKMRWLSAAVMLTLYTSSSWAFSIDDVAKQAQSLAGKGYEAPKSNLPSVFRDMKYADYQQIQFNHDKAYWNNLKTPFKLEFYHQGMYFDTPVKINEVTATAVKRIKYSPDYFTFGDVQHDKDTVKDLGFAGFKVLYPINSKDKNDEIVSMLGASYFRVIGAGQVYGLSARGLAIDTALPSGEEFPRFKEFWIERPKPTDKRLTIYALLDSPRATGAYKFVVMPGRDTVVDVQSKIYLRDKVGKLGVAPLTSMFLFGPNQPSPANNYRPELHDSNGLSIHAGNGEWIWRPLNNPKHLAVSSFSMENPQGFGLLQRGRDFSRFEDLDDRYDLRPSAWVTPKGEWGKGSVELVEIPTNDETNDNIVAYWTPDQLPEPGKEMNFKYTITFSRDEDKLHAPDNAWVQQTRRSTGDVKQSNLIRQPDGTIAFVVDFTGAEMKKLPEDTPVTAQTSIGDNGEIVESTVRYNPVTKGWRLVMRVKVKDAKKTTEMRAALVNADQTLSETWSYQLPANE
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: AQP1_RAT
Sequence: MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVASAILSGITSSLLENSLGRNDLARGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGSALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK
What is the function of this protein?
Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
What are the official names of this protein?
Aquaporin-1, AQP-1, Aquaporin-CHIP, Water channel protein for red blood cells and kidney proximal tubule.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AMD_BOVIN
Sequence: MAGFRSLLVLLLVFPSGCVGFRSPLSVFKRFKETTRSFSNECLGTTRPVIPIDSSDFALDIRMPGVTPKQSDTYFCMSVRLPMDEEAFVIDFKPRASMDTVHHMLLFGCNMPASTGNYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNHKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPPGGKVVNSDISCHYKKYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVEHPVDVSFGDILAARCVFTGEGRTEVTHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDIFRTIPPEANIPIPVKSDMVMMHGHHKETENKDKTSLLQQPKREEEGVLEQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDTRESAEQERGNAILVRDRIHKFHRLVSTLRPAESRVLSLQQPLPGEGTWEPEHTGDFHVEEALDWPGVYLLPGQVSGVALDPQNNLVIFHRGDHVWDGNSFDSKFVYQQRGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPKSKEGPLLTLGRSMQPGSDQNHFCQPTDVAVDPDTGTIYVSDGYCNSRLVQFSPSGKFITQWGEASLESSPKPGQFRVPHSLALVPPLGQLCVADRENGRIQCFKTDTKEFVREIKHPSFGRNVFAISYIPGLLFAVNGKPYFEDQEPVQGFVMNFSSGEIIDVFKPVRKHFDMPHDIAASEDGTVYVGDAHTNTVWKFTSTEKMEHRSVKKAGIEVQEIKESEAVVETKMENKPASSELQKIQEKQKLVKEPGSGVPAVLITTLLVIPVVVLLAIALFIRWKKSRAFGDSERKLEASSGRVLGRLRGKGGGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKDEDASESEEEYSAPPPAPAPSS
What is the function of this protein?
Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides (PubMed:2059626).  Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme.  The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:2059626).  The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:2059626).  Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (By similarity).
What are the official names of this protein?
Peptidyl-glycine alpha-amidating monooxygenase, PAM.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass membrane protein. Note=Secretory granules.
Protein: FADB_PSEFS
Sequence: MIYEGKAITVKALESGIVELKFDLKGESVNKFNRLTLNELRQAVDTIKADASIKGVIVSSGKDVFIVGADITEFVDNFKLPDAELVAGNLEANKIFSDFEDLNVPTVAAINGIALGGGLEMCLAADFRVMSATAKIGLPEVKLGIYPGFGGTVRLPRLIGADNAIEWIAAGKENRAEDALKVGAVDAVVAPDKLAEAALNLIKGAISGEFDYKAKRQPKLEKLKLNAIEQMMSFETAKGFVAGQAGPNYPAPVEAIKTIQKAANFGRDKALEVEAAGFVKLAKTSAAQSLIGLFLNDQELKKKAKAYDEIARDVKQAAVLGAGIMGGGIAYQSASKGTPILMKDINEHGIEQGLAEAAKLLVGRVDKGRMTAAKMAEVLNGIRPTLSYGDFGHVDLVVEAVVENPKVKQAVLAEVEAQVKDDTILASNTSTISISLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSELAVATTVAYAKKMGKNPIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAYLMDVVGIDTGHHGRDVMAEGFPDRMKDDRRSAIDALYEAKRLGQKNGKGFYAYEADKKGKQKKVADPSVHEVLAPVIYEQREVSDEDIINWMMIALCLETVRCLEDGIVETAAEADMGLVYGIGFPPFRGGALRYIDSIGVAEFVALADKYADLGPLYHPTAKLREMAKNGQSFFG
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: METK_RICPR
Sequence: MKNFVFTSESVSEGHPDKIADQISDAVLDEILKHDPNGRVACETFVTTGLVLVGGEITTNTYVDIEQVVRNKIQEIGYNNPNYGFDGSCCAVISSIIKQSPDIAMGIDNENEEEIGAGDQGMVFGYACNETKSLMPAPIYYAHLLMKRQAYLRKQNILSWLRPDAKSQVTLRYENNKPIVIDSVVLSTQHHPEIQQKDLIEAVIEEIIKPTLPTNLLHKDTKYLINPTGRFVIGGPVADCGLTGRKIIVDSYGGMAKHGGGCFSGKDPTKIDRSAAYMARYIAKNIVGAGLADRCEIQISYAIGVADPVSVYAETFGTSKLSNEQTTKLITEHFDMRPGKIIKNLKLHTQCYQKTATYGHFGREDENFTWEQLDKVDIFK
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CANB1_HUMAN
Sequence: MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
What is the function of this protein?
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase.  Confers calcium sensitivity.
What are the official names of this protein?
Calcineurin subunit B type 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
Protein: TGT_CHLCV
Sequence: MALKFHVLHQSKKSRARVGKIETAHGIIDTPAFVPVATNGALKGVIDHSNIPLMFCNTYHLLVHPGTEAIAAMGGLHKFMNRNAPIITDSGGFQIFSLAYGSVAEEIKSRGKKKGSSSILEVNDEGVWFKSYRDGHKLFLSPEVSVQAQKDLGADIIIPLDELLPFHSDEKYFLSSCSRTYVWEKRSLDYHKKDPRHQSMYGVIHGGIDPEQRKIGCQFVEDHPFDGFAIGGSLGRNLQEMLPVVDVTTSYLSKDRPVHLLGIGDLPSIHATVGLGIDSFDSSYPTKAARHGLILSSQGPIKIANQAYANDLSSLDPECTCATCTSNISRAYLRHLFKVHEPNAAIWASIHNLHYMQEVMKNIREQILNDEI
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: GSA_SALTY
Sequence: MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAELVTNLVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCTYNDLTSVRAAFEQYPQEIASIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVMTGFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGIHETLDELTTRLAEGLCEAAQEAGIPLVVNHVGGMFGIFFTDAESVTCYQDVMACDVERFKRFFHLMLEEGVYLAPSAFEAGFMSVAHSMDDINNTIDAARRVFAKL
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDHD_XANC8
Sequence: MTGQPSTPVRPGSVVRTVRRHRGGRSATVQDMVAAEMPVAFNYNGVPFAVMMATPEDLEDFALGFSLSEGIVDHPQDLRVVAVDTFLEGASLQIEIPPERAAALDQRRRNLDGRSGCGVCGNESIEAVLRVPPVLQSALRIDVDALARALDALHARQPIAAQTGAVHAAGWADAQGMVQLVREDVGRHNALDKLIGALARARVDATQGFAVVTSRASYEMAMKAAQARIPLLAAISAPTALAISLADSAGLTLIGFARDHDCVVYSHPQRLDLGVAVGEPA
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTRTR_BACSU
Sequence: MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGIFVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGELLAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLPAAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGMKGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTGMMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRDGLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIAVIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYFLYSRKHSLLNK
What is the function of this protein?
Involved in import of methylthioribose (MTR) into the cell.
What are the official names of this protein?
Methylthioribose transporter.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RF2_BUCAI
Sequence: MIENNMTTNQINSLNRRVQDLKRYLDYNKKKSRVLEIDLELSSPKTWTEQISIKKLNKEKYLLNSIIQNINEIEENIKEVVIFLELAIETQDNLVFKESLLEIQKIEQEIKKLEFYRMFSKKNDHYDCYIDIQSGSGGTDAQDWSKMLLRMYLRWADKKGFHTEIIDESIGEIVGIKSSTIKVSGEYAFGWFRTETGIHRLIRKSPFDSGKRRHTSFSSIFIYPDINEKIDININYSDLRIDVYRASGAGGQHVNRTESAVRITHLPTNIVTQCQNNRSQHKNKEQAMKQMQSKLYEIQMRKKQEEKQKIEQNKSDITWGNQIRSYILDNSKIKDLRTGVEKNHVQSVLDGDLDDFIEQSLIMGL
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_BRAHW
Sequence: MKILGIDTSCDDTSAAIVEDGKNVLSSVLSSSIDAHKEFQGVVPEIAARKHLEAILYVIDKALKDANTTLDDIDLFAVTNRPGLLGSLLVGVASAKSLAFSLNKPLLALDHIAAHIYSPHLTNDIEFPYIALVVSGGHTIITEVHDYGEYKVVGTTLDDAVGEAYDKVSKFLNLGYPGGPIIDRLAKEGNKEAIKYPIVLLNGIDEFNFSYSGLKTACVYSTKKYLKEGYEATNENIAAAFQISAIEPLYIKTLKYAEKSGIKRVTLSGGVACNSYLRDRFGNSKDFECYLPALKYTTDNAAMVAGLAYHMKDKQNFADYNLDCFSRVLNKKYNKNKSAK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YLH8_CAEEL
Sequence: MRTVKFKGMGIRHLDDGRFVIVPPTFLWWPAKHVILSIILANAIITTFFLLQASNILASILLCSILLSIVFAMGYIRESFALIYIHFIYCLLYIVFSFLFIPTFYYDQKICTNAAICKTVQEWLEELVTTVASRWIYAFTGTTLITHIMMTPVSLRMMKYSASCEALEKMMTDEEYVKKMKRLAIIHPERYHPASV
What are the official names of this protein?
Uncharacterized protein C48B4.8.
Protein: ASA1_PENRW
Sequence: MDTKSVQVQSPATPVYILRGHASPVHALHIYSQNLRLVSGDANGWIVVWDLVTKRPVTAWKAHEGAVLEARGFDVGSGATEIYTHGRDHKLCVWKLRPEDETFLNKTLPVDATESAQPGSKTQPWLLHSLPVNALNFCAFSMAFVNPDGLPAFPSQSGRPENTLFAVPNALDSGGVDIFHLPSERRISTIPSEQSPKTGMLMAVNLFISPSGDLYVASAYEDGHVMVFVHRGALKSASFEREYISNNPLKWDKLYAGRPHSQPVLSLDVAPSHGYFISSSADALIVKHPIPNTGSAGYIPTAGYKEESPLKIVNTKHSGQQGLRIRSDEKVFATAGWDSRIRVYSGKTMKELAVLKWHKDGCYSIAFGDTESMSSLVSPSSESAKQEPRDADQGAAGQTTVDGRNYSLATVQQQRNQKVQQTHWLAAGSKDGKISLWDIY
What is the function of this protein?
Component of the ASTRA complex involved in chromatin remodeling.
What are the official names of this protein?
ASTRA-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ASA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NIRDL_PARPN
Sequence: MTMDDLDLRLLDGFQRDLPLETRPFAAIANRLNTSEAEVIARLARLRDEGLIARIGATCRPNTAGASTLAALRVPVRRIDKVAALVGAEPGVNHSYLREGSDWNLWFVATAPDAEALEESLVRIETATGLVPLSLPLVRAFNIDLGFPLIGPRRAMALDRPTDLDVLRPRDKALMQALTTGLALVPRPFVALGQALGRSEAEVISRIRALAAARILTRVGVIVRHRALGWCENAMVVWRLPEPAVEAAGTALAAVPGVTLCYQRRTVPGLWNWPLFCMIHARSRAEAMEVLVQARALPELQGVPHRILFSTRCFRQRGAVIAEVAA
What is the function of this protein?
Involved in heme d1 biosynthesis.  Catalyzes the decarboxylation of siroheme into didecarboxysiroheme (PubMed:21969545).  Siroheme is probably decarboxylated to monodecarboxysiroheme, which is in turn decarboxylated to didecarboxysiroheme (PubMed:21969545).
What are the official names of this protein?
Siroheme decarboxylase NirDL subunit.
What is the protein family that this protein belongs to?
Belongs to the Ahb/Nir family.
Protein: ARLY_METM7
Sequence: MNILRRGRLGSNVKEDVMKFTTSLEFDKEIFESDILCDIAHTTMLIEQNVISEENGKKIIAELKKIAEKGMENLDLDPSLDDIHMVIESELIKELGEDVAGRMHTGRSRNDEVATDLRLSLRKKVLEIIGHLITMEQNMLKVSNEHKETLTVGYTHLQQAQPVTFGHHILSHVSAIERDISRFFDTYNRINISPLGCSAMATTGFNLNRKRTQELLGFYDIIENSMDGVSSRDFIVETMANISMLGTNLSKICEELVVFSSAEFNTIEIANEYTSTSSIMPQKKNPDVAEITRAKLSTLNGELVTVLTIMKALPNTYNRDLQEISPHLWKSVYTLIDCIQMVDGMISTIKVNKERMKENAEKNYSTATELADTLVRECGIAFRMAHGIVGELVKRSIEEKVEIKEIILEVLEKNNLSLSQEKIDTALDPFENVKLRNVIGGPAPEEVERAISSFNTKISTHKEKLDEKIAEVNTVNKNLLK
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SALPC
Sequence: MAKRDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDAQKRAAYDQYGHAAFEQGGMGGGFGGGFNGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMDLTLEEAVRGVTKEIRIPTLEECDVCHGSGAKAGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCHKCHGHGRVEKSKTLSVKIPAGVDTGDRIRLAGEGEAGEHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVMLKVPSETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLSEKQKQLLKDLQESFGGPTGEKNSPRSKSFFDGVKKFFDDLTR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 3MGH_CHLPD
Sequence: MPIVPKHFFERPTLELAEKLLGKIFVRRISDTIRLKGRIVETEAYCGEFDEASHAWRGKTTRNSMMFNSPGMLYVYLAYGSHYMLNIVSEPENIPGAVLIRAMEPIDGLMFMKEQRGTALATSLLSGPGKLTQAFAIRGDCNGKDLFNNEFFLENAQDIPQNAMGSGSRVGITKSRQLQWRKYILNNPHVSKARGS
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: SIGA_MYCBO
Sequence: MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKPASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVEELDAEPDLDVEPGEDLDLDAADLNLDDLEDDVAPDADDDLDSGDDEDHEDLEAEAAVAPGQTADDDEEIAEPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is the primary sigma factor during exponential growth.
What are the official names of this protein?
RNA polymerase sigma factor SigA, Sigma-A.
What is the protein family that this protein belongs to?
Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPB_PROM2
Sequence: MVATPSTSSQTKGVVRQVIGPVLDVEFPAGKLPKILNALRIEAKNPAGQDIALTAEVQQLLGDHRVRAVAMSGTDGLVRGMEAIDTGAPISVPVGEATLGRIFNVLGEPVDEQGPVNTKDTAPIHRAAPKLTDLETKPKVFETGIKVIDLLAPYRQGGKVGLFGGAGVGKTVLIQELINNIAKEHGGVSVFGGVGERTREGNDLYEEFKESGVINADDLTQSKVALCFGQMNEPPGARMRVGLSALTMAEHFRDVNKQDVLLFVDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGELQERITSTLEGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLARALAAKGIYPAVDPLDSTSTMLQPSVVGDEHYKTARAVQSTLQRYKELQDIIAILGLDELSEEDRLTVDRARKIEKFLSQPFFVAEIFTGMSGKYVKLEDTIAGFNMILSGELDDLPEQAFYLVGNIDEVKAKAEKINSEK
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: NOCT_HUMAN
Sequence: MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS
What is the function of this protein?
Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539).  Shows a small preference for NADPH over NADP(+) (PubMed:31147539).  Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338).  Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity).  Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity).  Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity).  Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity).  Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity).  Critical for proper development of early embryos (By similarity).
What are the official names of this protein?
Nocturnin, Carbon catabolite repression 4-like protein.
What is the protein family that this protein belongs to?
Belongs to the CCR4/nocturin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Mitochondrion.
Protein: NAP1B_ARATH
Sequence: MSNDKDSMNMSDLSTALNEEDRAGLVNALKNKLQNLAGQHSDVLENLTPPVRKRVEFLREIQNQYDEMEAKFFEERAALEAKYQKLYQPLYTKRYEIVNGVVEVEGAAEEVKSEQGEDKSAEEKGVPDFWLIALKNNEITAEEITERDEGALKYLKDIKWSRVEEPKGFKLEFFFDQNPYFKNTVLTKTYHMIDEDEPILEKALGTEIEWYPGKCLTQKILKKKPKKGSKNTKPITKTEDCESFFNFFSPPQVPDDDEDLDDDMADELQGQMEHDYDIGSTIKEKIISHAVSWFTGEAVEADDLDIEDDDDEIDEDDDEEDEEDDEDDEEEDDEDDDEEEEADQGKKSKKKSSAGHKKAGRSQLAEGQAGERPPECKQQ
What is the function of this protein?
May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity).  May function in nucleotide excision repair (NER).  Involved in somatic homologous recombination.
What are the official names of this protein?
Nucleosome assembly protein 1;2, AtNAP1;2, Nucleosome/chromatin assembly factor group A2.
What is the protein family that this protein belongs to?
Belongs to the nucleosome assembly protein (NAP) family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Predominantly located in cytoplasm.