PharMolix/UniProtQA huggingface dataset:
Protein: RL18_METPE
Sequence: MAVGPRYFVPFRRRREGKTDYYKRGKLIVAEQPRMVVRKTNRHIIVQMIVAEMEGDKTLVTANSAELLDYGYKGSTSNTPAAYLTGMLFAVKALNADHPAAILDIGLNRATYGAKVFAALKGAVEAGLDVPHGEEILPADERVKGEHIAAYAPDRAGDLVENVESAAQTIMKELA
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: GCSPB_STAMF
Sequence: MFRQSRWDEPLIFELGNKGRKGFIVPEPEEEVKRKVGGIRIPEKILRKKPPNLPEVSEVEVIRHYTRLTEMSYGVDNGPVPLGSCTMKYNPRIAWEISNDYRINMLHPLQDERTIQGLLEILYELQKWLANITGMDYCSLHPAAGAHGEFSGILIIRKYHELKKQLDRKSEIIIPDSAHGTNPASASMGGFKVVEVPSGEDGNIDMEALKSVVGESTAGLMITNPSTLGLFEENVVEISKIIHGVDGLLYYDGANLNGIMGYTRPGDMGFDIAHINIHKTFGAPHGGGGPGAGPVCVKDKLIDEERNIWLRDLLPGYRVVYDEKTGLYKLVNNEKYSIGLLKAFFGNIVPLIWGYTYILMLGSKGLRTVTEQAVLNTNYFISLVKDIRGYDIPYGKDRYRKHEVVLSAKPLYDDTGVSAEDVAKGLLDAGFYAPTIYFPLIVHEALMTEFTESETIEYIEKYAERLQEISTIAYSDPEKAKEWPLNTSVRRVDNVRANHPKTLAPTWRIYMEKVCRKYSEC
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: DAPB_ARTBC
Sequence: MRVGSRINDEEAMPLTAPESRARDSIDSSSTASISLTLVEGASHATTEPSKPAHNHNGRAQGNYAEKYRDDLEEDWEEDNYIPSNGKSNQRRTLIVFWLLVALCVGGWAVAFLFFVTSPGNKTSTSPHSGSNSPEGDVTKPGIPATGKKIPLDDAIGGVWSPAEHTISWITGAKGEDGLLLQKSEGGTGPYLHVEDVRNIHGTQSNNNSIVLMKESVFFVNDERISPEKVWPSPDLKTVLAMTREKKNWRHSFTGLYWLFDVETQTAQPLDPDAPNGRIQLATWSPTSDAVAFTRDNNLYIRNLTSKSVKAITTDGGTNLFYGIPDWVYEEEVFEGNCATWWSLDGKYISYLRTNETLVPEFPIDFYLSSPPGYSPKPNEESYPYVQQIKYPKAGAPNPTVNLQFYDVEREESFSVDVKDTLKDDDRLIVEVIPGSKGKVLVRETNRESYIVKVAVIDANKREGKIVRSDNIDEIDGGWVEPSHTTTYIPADPSAGRPDDGYIDTVIHEGYIHLAYFTPLENPKPKMLTTGKWEVVAAPSGVDLKNNVVYFVATKESPIDRHVYSVKLDGSELQMLKDSDKSAYYDVSFSHGAGYMLLKYQGPQIPWQKLISSPSNADNYIEILEENKKLAKLSNEFSLPSLHYSTINVDGFELPVVERRPPNFDETKKYPVLFQLYGGPGSQTVNKKFLVNFQTYVASSLGYIVVTVDGRGTGFNGRKFKCIVRRNLGHYESHDQIQAAKAWGKKPYVDKTRMAIWGWSYGGFMTLKTLEQDAGETFQYGMAVAPVTNWRYYDSVYTERYMHMPQNNEGGYENASISNATNLSQNTRFLIMHGSADDNVHFQNTLTLLDKLDILGVHNYDMHVFPDSNHGIYFHHAYKMVHQRKYFNLSFLGHGFFSFYSNFLPIRSF
What is the function of this protein?
Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
What are the official names of this protein?
Probable dipeptidyl-aminopeptidase B, DPAP B.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9B family.
What are the subcellular locations of this protein?
Vacuole membrane; Single-pass type II membrane protein. Note=Lysosome-like vacuoles.
Protein: ILVD_PSEPW
Sequence: MPDYRSKTSTQGRNMAGARALWRATGMKDEDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADAVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLASHGLDLVDAMVIAADSSASDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHADREQLFLTAGRTIVELCKRYYGENDDSVLPRSIANFKAFENAMMLDIAMGGSTNTILHLLAAAQEGEVAFDLRDIDRLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGSLARGGLLHTDLPTVHSRSMEEAIAKWDITQTDDEAVHTFFKAGPAGIPTQTAFSQSTRWETLDDDRENGCIRSFEHAYSQEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGNAKIFESQDSAVRGILADEVKAGDIVIIRYEGPKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVRDGDKVLIDIPNRSINLQVSDEELAARRVEQDKKGWKPAEVRPRKVTTALKAYALLATSADKGAVRNKAMLEGL
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: THIE_ECOSE
Sequence: MYQPDFPPVPFRLGLYPVVDSVQWIERLLDAGVRTLQLRIKDRRDEEVEADVVAAIALGRRYNARLFINDYWRLAIKHQAYGVHLGQEDLQATDLNAIRAAGLRLGVSTHDDMEIDVALAARPSYIALGHVFPTQTKQMPSAPQGLEQLARHVERLADYPTVAIGGISLARAPAVIATGVGSIAVVSAITQAADWRLATAQLLEIAGVGDE
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: BTG4_HUMAN
Sequence: MRDEIATTVFFVTRLVKKHDKLSKQQIEDFAEKLMTILFETYRSHWHSDCPSKGQAFRCIRINNNQNKDPILERACVESNVDFSHLGLPKEMTIWVDPFEVCCRYGEKNHPFTVASFKGRWEEWELYQQISYAVSRASSDVSSGTSCDEESCSKEPRVIPKVSNPKSIYQVENLKQPFQSWLQIPRKKNVVDGRVGLLGNTYHGSQKHPKCYRPAMHRLDRIL
What is the function of this protein?
Adapter protein that bridges CNOT7, a catalytic subunit of the CCR4-NOT complex, to EIF4E (By similarity).  Facilitates maternal mRNAs decay during the maturation of oocytes and in the fertilized egg, and is required for the maternal-zygotic transition (MZT), zygotic cleavage and initiation of embryonic development (PubMed:32502391).
What are the official names of this protein?
Protein BTG4, BTG family member 4, Protein PC3b.
What is the protein family that this protein belongs to?
Belongs to the BTG family.
Protein: ISPE_FRATW
Sequence: MANIKAKKYYSYAKINLFLHILNKRTDGYHNLQTWFTFLDLKDQLTFSFNNSREINISSNISIAAKQDNLVYKAIKKFQQSYRVQDIGVDIEIKKNIPMGAGLGGGSSNAATTLIALRDYYLPQLSNEEMIPLAAKLGADVSIFVYGKSAWAEGIGEILYHKDFSPQYALLIKPDIHISTKEFFTSEDLIKSSVLISKDLGFDKSIMHNDFENVFYAKYPEFSQYLKELDSDFRMTGTGSCFYLLSADKNKLEQLARKINKPLDKWLVKTLNYVY
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: PP19_ARATH
Sequence: MMTSMEGMMEMGVLDDIIRRLLEGKGGKQVQLSEVEIRQLCVNARQIFLSQPNLLELHAPIRICGDIHGQYQDLLRLFEYGGYPPSANYLFLGDYVDRGKQSLETICLLLAYKIRYPSKIFLLRGNHEDAKINRIYGFYDECKRRFNVRLWKIFTDCFNCLPVAALIDEKILCMHGGLSPELENLGQIREIQRPTEIPDNGLLCDLLWSDPDQKNEGWTDSDRGISCTFGADVVADFLDKNDLDLICRGHQVVEDGYEFFAKRRLVTIFSAPNYGGEFDNAGALLSVDQSLVCSFEILKPAPASSTNPLKKVPKMGKS
What is the function of this protein?
Serine/threonine-protein phosphatase that possesses phosphatase activity toward para-nitrophenyl phosphate (pNPP) in vitro.
What are the official names of this protein?
Serine/threonine-protein phosphatase PP1 isozyme 9, Type one protein phosphatase 9.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: MNME_CHLPM
Sequence: MTERPLTPEAGEAIAAIATPVGVGALAIVRMSGRGVLEIADRVFRKKGGTAFSFKEAEGFSAHFGTLSDSRGMVDEVIALVFRAPSSFTMEDMVEFTCHGGPVVVRHLLQALLDSGCRLAEPGEFTRRAFLSGRIDLLQAEAIGEMIHARTESAFRTAVTQMQGNLSRHLQEMRAGLLQSCALLELELDFSEDDVEFQSRDALRLEVGRLQGEILRLVESYREGHLLTEGVAAVIAGRPNAGKSTLLNALLGHERAIVSHMPGTTRDYIEECFIHEKTMFRLTDTAGLRHSDEEVEHEGIRRSYRKISEADLMLYIIDSSEGDMQQEAAAARELRQRHPESRMIVVANKTDLAPDAGGMIAQLQSETACPVIAMAASKGDGLNELKSTMAGMVEGLDKLHEASVLVTSLRHYEALRNAADSLDNALQLITAREPAELIAFELRSALDYVGEITGKVVSQELLNTIFDQFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NIKR_ECO27
Sequence: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVYEHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMSDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel.
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: M2_I75A0
Sequence: MSLLTEVETPIRSEWECRCNDSSDPLVVAASIIGILHLILWILDRLFFKCIYRFFEHGLKRGPSTEGVPESMREEYRKEQQSAVDADDSHFVSIELE
What is the function of this protein?
Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.  After attaching to the cell surface, the virion enters the cell by endocytosis.  Acidification of the endosome triggers M2 ion channel activity.  The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur.  Also plays a role in viral proteins secretory pathway.  Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.
What are the official names of this protein?
Matrix protein 2, Proton channel protein M2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses matrix protein M2 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type III membrane protein. Note=Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Protein: LTR3B_XENLA
Sequence: MAEELKRFLYKKLPSIEGLHAIVVSDRDGVPVIKVANENAPELALRPSFLSTFALATDQGSKLGLSKNKSIICYYDTCQVVQFNRLPLVVSFIASSDANTGLLLSLNEELGDLFEELQHAVEI
What is the function of this protein?
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids.  As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids.  Adapter protein that may regulate the MAP kinase cascade.
What are the official names of this protein?
Ragulator complex protein LAMTOR3-B, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3-B, Mitogen-activated protein kinase scaffold protein 1.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR3 family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NS1AB_ANV1
Sequence: MASAGPTGAGARPPKAFTAQAGLAKLVNPAGLNSILARGKEKFGGTQAWKELMGCDVIFARSISHWYGIKGTTYYELTVALGQPLYKPVTDPELTEEEKAVMTAVQSRFAQSNSSVVLTRTLLNKTCELKDRIRELTDELGQTEVHLAREKVKAAALKLENRKLFVENQELKDQLEKERTKHGWKGLKTLCLWIFLATLIGGYITGSNAACTLVDVPSPMKVGYDTFKQMCIHKDSYLPDGAFDKESLALECSKQMDYMDCKEVITDSISGKTSFAGMLRDVFRVDEIVTAIRTVVRFAMDFSLAYPICVMFVLILTRNKKHAIISACCALVAKCCGLRLLPFTLVLTYAPSETAIAGCIYGLGYISIPLVTFLHWVGLVLKAILVPDDCYIGTRVSHALAWSIMLPMWIITQELMAFTEFPLELQIVTTVVVCTAGFGFRYLTGTVTITEPDGTVKKYKRIFNAKSAIGTISTVFFEKAKAIRGVIPSFPSKADNIVKIEVDVDGGSAGVGFRLGNYIYTAGHVVGEAKIAKITWKGLTSQAKVLGHIELPLFTDTLARLEIPKPFQQLPVFRLAKSSENDYVQMVCFDNQLQNVVTFSGWANIDGDYLNAPFETYAGTSGSPIINRDGRMLGVHFGSNAVVSQGFVITRLFATEPAVKQCKSDEDLADEIVRKVMGGIRISFASLTSELEKQRDELNALKQMVNDLIDTDLVALEKKKGKTKRTVRGQKHKTKAISKAAFMKTKVLTEEEYRRLEEEGFTKDEIKDIVDNLREQAWLDYQNQLDEEGDDDWYEQMEEDQRINDQIDQNIERDLEDRGEWYGQRKITFKQRAMLRFIQLGRQQQVATVSFPDGYEDRAEELYNKVVTTEDLPEGETSEAALSLPNKIVHQAGKRLNFKHVKIHPDKTFMKSGVTQIEEKPEGDIILKAKTTTLAPKEEPVIQQVEQQPQVEQQQQPQQPVVEEKKRTPPPKPQRKPKTGAKAKCLDCGETFVERQDFHVCKSKKLNEPPSGGYTPVPDHLRWNNWQIYMEPLDLRITVPENYPILGHIAIDKLVERKKKVNDPLLKMLEQPKCEGFTSTTWTRKAYTKSFEKFDYGDAVDFVQDYPELTAFADAAVLAEVGYMEGTHVIPIQETSKNMDSTPAFPKMLDFDSERDYLEAHGMKEYIDTQLGVQSGKPLWWCFLKNEILKEKKVSEDDIRIITCSDPVITRLGASFDSEQNERMKERTETHHAQVGWTPFFGGLDKRVRRITSCGRTQVLELDWTRFDGTIPVQLFQRMRELRKFFLTRRSRRRYGKLLDWYNAQLTDRITLLPTGEVTHVKKGNPSGQFSTTVDNNLVNEWLTAFEFGYQHLENHGIIPTVRDYRANVDFLCYGDDRLLAFNPSFVNYDPQVTIDMYKNIFGMWVKPENIKLFDSPTGSSFCGFTLVKPHGQWVGVVNVNKLLQSLKTPTRRLPDLESLWGKLVSLKIMCYHSDPEAVSYLSNQIRRVEEYARAEGIELPEVGPDFYRKIW
What is the function of this protein?
Protein covalently attached to the 5' extremity of the genomic and subgenomic RNAs.
What are the official names of this protein?
Non-structural polyprotein 1AB.
What is the protein family that this protein belongs to?
Belongs to the astroviridae polyprotein 1AB family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: RHO_ECOLI
Sequence: MNLTELKNTPVSELITLGENMGLENLARMRKQDIIFAILKQHAKSGEDIFGDGVLEILQDGFGFLRSADSSYLAGPDDIYVSPSQIRRFNLRTGDTISGKIRPPKEGERYFALLKVNEVNFDKPENARNKILFENLTPLHANSRLRMERGNGSTEDLTARVLDLASPIGRGQRGLIVAPPKAGKTMLLQNIAQSIAYNHPDCVLMVLLIDERPEEVTEMQRLVKGEVVASTFDEPASRHVQVAEMVIEKAKRLVEHKKDVIILLDSITRLARAYNTVVPASGKVLTGGVDANALHRPKRFFGAARNVEEGGSLTIIATALIDTGSKMDEVIYEEFKGTGNMELHLSRKIAEKRVFPAIDYNRSGTRKEELLTTQEELQKMWILRKIIHPMGEIDAMEFLINKLAMTKTNDDFFEMMKRS
What is the function of this protein?
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.  RNA-dependent NTPase which utilizes all four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
Transcription termination factor Rho, ATP-dependent helicase Rho.
What is the protein family that this protein belongs to?
Belongs to the Rho family.
Protein: RL14_GEOSW
Sequence: MIQQESRLKVADNSGAREVLVIKVLGGSGRRYANIGDVVVATVKEATPGGVVKKGQVVKAVVVRTKRGVRRSDGSYIRFDENACVIIRDDKSPRGTRIFGPVARELRDKDFMKIISLAPEVI
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: Y2509_CLOPE
Sequence: MQKIAIITDSSCDLTIDEIKDYNLNILPLKIIYKDREYNDIFDIKPIDVYENLHNEVPTTSLCSPDYINSVLDKLEAEGYTHLIGIFISSSLSGTFNAARLVIEERSSFKYYLFDSKIIGYPLGSIVIKAAEFVKEGKSFEEIIEALSIIREATTGFYTLNTLEYLRRGGRIGKVAGTVGDLLHLKPIISVDEHGAYTTIAKARGRKQSLKKLASIILEHLDEGKCNVAILNGMAEEEANQVLDSISSHPNLLKSQVRAIGAAMGVHAGPGMVGVSIQKEI
What is the function of this protein?
May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
What are the official names of this protein?
DegV domain-containing protein CPE2509.
Protein: Y893_FINM2
Sequence: MSGHNKWSKIKNKKGSEDARRGKIFTKMARAITVAVREGGADPEYNPSLKSVIEKARAENMPNDNIDRAIKKASGDGDSANYENIVYEGYGPEGVAVIVECLTDNRNRTASDVRHYFDKFGGNLGQNGSVSFMFQRKGLLLIDADSLDEEEVMMDSLDAGAEDFEADDGIFVINTAMEDFAQVRDTLLDKGYKFVKSDLVYEPSNYVKINDESNVDKMEKLIDNLEDSDDVQQVSHNWDNE
What are the official names of this protein?
Probable transcriptional regulatory protein FMG_0893.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F93_SSV1
Sequence: MKSTPFFYPEAIVLAYLYDNEGIATYDLYKKVNAEFPMSTATFYDAKKFLIQEGFVKERQERGEKRLYLTEKGKLFAISLKTAIETYKQIKKR
What is the function of this protein?
Probable transcription factor that recognizes a (pseudo-)palindromic DNA target sequence.
What are the official names of this protein?
Protein F-93.
Protein: THIM_SHISS
Sequence: MQVDLLGSAQSAHALHLFHQHSPLVHCMTNDVVQTFTANTLLALGASPAMVIETEEASQFAAIASALLINVGTLTQPRAQAMRAAVEQAKSSQTPWTLDPVAVGALDYRRHFCHELLSFKPAAIRGNASEIMALAGIANGGRGVDTTDAAANAIPAAQTLARETGAIVVVTGEVDYVTDGHRAVGIHGGDPLMTKVVGTGCALSAVVAACCALPGDTLENVASACHWMKQAGERAVARSEGLGSFVPHFLDALWQLTQEVQA
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: DCUP_PSEA7
Sequence: MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRATRARAGDFMSLCMNPELACEVTLQPLDRYPQLDAAILFSDILTIPDAMGQGLYFETGEGPRFRKVVSSLADIEALPVPDPEKDLGYVMDAVRTIRRELNGRVPLIGFSGSPWTLATYMVEGGSSKDFRKSKAMLYDNPRAMHALLDKLAQSVTSYLNGQIRAGAQAVQIFDSWGGSLSAAAYQEFSLAYMRQIVDGLIREHDGRRVPVILFTKGGGLWLESMAEVGAEALGLDWTCDIGSARARVGERVALQGNMDPSVLYANPAAIRAEVARILAAYGKGTGHVFNLGHGITPEVDPAHAGAFFEAVHELSAQYHG
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPA_WOLSU
Sequence: MESFGVLSMKKLVAYITAALPDKEFTIDLALALSASGVDSLELGVPFSDPVADGPIIEHANLLALQKGFSLQDLYEITEKISPSIDTLWMGYLNPFHKVGFEQTCQKAKSLGVSGLIIPDVPFEESAPFEEQCLQNNLALIRFIAPTLGTSRIATIAPMARKFIYLVAYAGITGSGREEPLSPLIEEIRAINPEIPLYLGFGVNEHNAKEKSKEVDGVIVGSALVKVLLDERLTNTQKMTTICALAKSIKESINS
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: DHH1_PICST
Sequence: MSEQNWKQNLNLPQRDTRPQTEDVLNTKGKSFEDFNLKRELLMGIFEAGFEKPSPIQEESIPMALAGRDVLARAKNGTGKTASFIIPSLQQIKPKLNKIQALILVPTRELALQTSQVVRTLGKHLGIQCMVTTGGTSLKDDILRLNDPVHVLVGTPGRVLDLAARSVADLSECPLFVMDEADKMLSREFKGIIEQILEFFPKNRQSLLFSATFPLAVKSFMDKHLNKPYEINLMDELTLRGITQYYAFVEEKQKLHCLNTLFSKLQINQSIIFCNSTNRVELLAKKITELGYSCYYSHAKMPQQARNKVFHEFRQGKVRNLVCSDLLTRGIDIQAVNVVINFDFPKTAETYLHRIGRSGRFGHLGLAINLMSWNDRYSLYKIEQELGTEIKPIPATIDRKLYVADNEDAIPKPFKIEQLPKGNEKVHTRAGYEYKGQPEVQSGQQHAQQQLQPSQQPQQQLQQPQQPQAAPQGYPPAFNGYPPYQQYPPQAGGYPPPQFNGYQAAPGQQ
What is the function of this protein?
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1.  Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs.  May also have a role in translation and mRNA nuclear export (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DHH1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, P-body. Note=Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.
Protein: OXBP_THEMA
Sequence: MKEGTGMVVRSSEITPERISNMRGGKGEVEMAHLLSKEAMHNKARLFARMKLPPGSSVGLHKHEGEFEIYYILLGEGVFHDNGKDVPIKAGDVCFTDSGESHSIENTGNTDLEFLAVIILL
What is the function of this protein?
Binds oxalate.
What are the official names of this protein?
Oxalate-binding protein, Putative oxalate decarboxylase.
Protein: MACB_CHLPD
Sequence: MNPLLELLDVHRTYQIGETTVNALRGVSLTIDRGEFVAIMGASGSGKSSLLQILGLLDNPDKGEFKILGNNVNTLSEDEQAGVRNNVAGFVFQQFHLLKRMTIVDNVRLPHIYSGLKGDFRQEAIARLKLVGLEERIDHTPNQLSGGEQQRVAIARALVRDPLIIFADEPTGNLDSKNSAEIMKIFTALHEEGKTIIMVTHENDIAAYACRVIIMKDGLIVSDERKAEMQPSRAVTGESAFDISGSGKGSIWQDGRFTGFMAQAFQSILANKMRTFLSVLGIFVGVASVIAMMALGEGAKSAMQEQLKSMGSNMLSIRGGSAKIRGAAQGAGAVARFSFNDVNDIASLGKLVKNASGVVNGSARIVYGNKNWSSTLTGVGFDYGTMRASIPAIGRWFTREEIQIREKSAIIGVTVVKEIFGSSNPIGKTIKINRINFKVIGIAPAKGFSGPQDEDDVVIIPVTTAMYRVLGKDYLSSIFVEVASPGLMGQAKTAITELIRKKHRLEEGDDSFNIRDMTEIQKMLSSTTQTMSLLLGSIAAISLLVGGIGIMNIMLVSVTERTREIGLRKAIGARKNDIMLQFLIESVGMTISGGLIGVFAGVGISLILAFFAGWAVKTSLLSVVLATTFSALIGVFFGLWPARKAAALKPVEALRYE
What is the function of this protein?
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DRP35_STAHJ
Sequence: MTNQSLPKLTYTGASKSAVPIISESELQTVTAEPWLKISDEGLQLEGLVFDRDHNLFLCEVFGGKIFKVDIDTKKVSTAFQSTKQNPAAVKIHKDGRLFTCYLGDFESTGGIFATDEHGEQFEEIISELNTEYCIDDMVFDSKGGFYFTDFRGYSTNPKGGVYYVSPDFKTVTPVIQNISVANGVALSTDEKILWVTETTTNRLHRIQLEDDGVTIAPFGATIPYYFTGHEGPDSVCIDSDDNLYVAMYGQGRVLVFNKRGYPIGQILMPGRDEGKMLRSTHPQFIPGTNQLLICTNDIENDSEGGSMIYTVEAFAKGHESYQFQ
What is the function of this protein?
Exhibits lactonase activity.  Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis (By similarity).
What are the official names of this protein?
Lactonase drp35.
What is the protein family that this protein belongs to?
Belongs to the SMP-30/CGR1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: O16A_CONCT
Sequence: MKLTCVVIVAMLLLTACQLITANDSRGTQKHRALRSDTKLSMSTRCKSTGASCRRTSYDCCTGSCRSGRCG
What is the function of this protein?
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels.  This toxin blocks N-type calcium channels (Cav2. 2/CACNA1B) (PubMed:10938268).  Shows a weak voltage-dependent reversibility (PubMed:19892914).  It is noteworthy that ancillary subunits beta modulate recovery from this toxin block (PubMed:19892914).  Cav2. 2/CACNA1B expressed with the ancillary subunit CACNB2a (isoform 2a) shows a low recovery from this toxin block, whereas Cav2. 2/CACNA1B expressed with CACNB3 does not exhibit recovery at all (PubMed:19892914).
What are the official names of this protein?
Omega-conotoxin CVIA.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O1 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: FIEF_SALNS
Sequence: MNQTYGRLVSRAAIAATAMASALLLIKIFAWWYTGSVSILAALVDSLVDIAASLTNLLVVRYSLQPADDEHTFGHGKAESLAALAQSMFISGSALFLFLTSIQNLIKPTPMNDPGVGIGVTVIALICTIILVTFQRWVVRKTQSQAVRADMLHYQSDVMMNGAILIALGLSWYGWHRADALFALGIGIYILYSALRMGYEAVQSLLDRALPDAERQEIIDIVTSWPGVSGAHDLRTRQSGPTRFIQIHLEMEDNLPLVQAHFVADQVEQAILQRFPGSDVIIHQDPCSVVPREGRKFELV
What is the function of this protein?
Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+).  May be involved in zinc and iron detoxification by efflux.
What are the official names of this protein?
Cation-efflux pump FieF.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.