PharMolix/UniProtQA huggingface dataset:
Protein: SFT2C_MOUSE
Sequence: MADLHRQLQDYLKQGKASRPAAAEPLLGAKAAEEPEAGAWLGSRVLRWPWAQSAAEPPPAGLRCLPSVTRGQRLVAGGLCLLLAALCFGLAALYAPVLLLRARKFALLWSLGSVLAWASAALLRGGPACGRLLRGEETPSRSTLGYAAALGATLYAALVLRSTVLTALGACAQVAALLYALIGLLPWGGVTALRLALGRLNRGTGLANALPV
What is the function of this protein?
May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
What are the official names of this protein?
Vesicle transport protein SFT2C, SFT2 domain-containing protein 3.
What is the protein family that this protein belongs to?
Belongs to the SFT2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: APAG_XANP2
Sequence: MYRAITRNIQVTATPRYVAERSEPDQGRHFWAYTVEVANLGQETVQLKGRHWVITDANGHTEEVHGAGVVGEEPTLPPGGRFEYTSGVPLNTSTGIMSGHYEMLADNGETFSIEIPAFSLDVPDVRRVLN
What are the official names of this protein?
Protein ApaG.
Protein: RL18_MYXXD
Sequence: MPTKIEARLKRKNRIRKKLSGTTERPRLTVYKSLKHIYAQVVDDTTGKTLAFASSLSKDLKGQDEGDKKADAKRVGALIAQKCKAANVEAVVFDRNGFPYHGRIAAVADAAREAGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: PYREL_THEVO
Sequence: MKSIEELYKRALELKNKGMSDKEISTELHLSVNTVTWLLSKEFLKEGAVQDVKIGWRSLGVFGSRIISIAEVMSDIIREEMQRNSFEVDSILGIAINGIPYATMVSYLMDKELIVYRPHPARKEGFFSSNFAGVEGKRIVIIDDVASTGETLKRTITDVTKEGGKAVLCVILASKMGVDDLNGVPVRSLLRTRIIGGT
What are the official names of this protein?
PyrE-like protein.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein: FPG_ECOLI
Sequence: MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDQPVLSVQRRAKYLLLELPEGWIIIHLGMSGSLRILPEELPPEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTKELEGHNVLTHLGPEPLSDDFNGEYLHQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVIKAVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATFYCRQCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and its derivatives such as guanidinohydantoin:C and spiroiminodihydantoin:C, however it also acts on thymine glycol:G, 5,6-dihydrouracil:G and 5-hydroxyuracil:G.  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.  Cleaves ssDNA containing an AP site.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: PTH_COPPD
Sequence: MLLIVGLGNPGIEYEKTRHNIGWWVLDLLRTKLTGLNLRLLCYSRVYELKHELKKEVDFIVYPLTYMNNSGKAVKCLYEPRMDLVVIHDDLDLTVGKTRVRFGGSSAGHKGVSSIIDALGTDSFWRVKVGIGRPFSKQEVINYVLGEPQKNEKEVLIRAADYIADQLCLLITDRNFSRFQQNINSFNSNENN
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_SODGM
Sequence: MRKQVAIFTDGSCLGNPGPGGYGAILRYKQHEKTFSAGYRLTTNNRMELMAAIVALEALTDACEVVLSTDSQYVRQGITQWIHNWKKRGWKTAYKKPVKNVDLWQRLDAAIQPHTLRWDWVKGHSGHPENERCDELARTAACHPALEDIGYRVEAQTSGGRAD
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_CLOBJ
Sequence: MSLQAPKGTKDLLPTESYKWQYLENKFRNIAADFGCREIRTPVFEYTELFQRGVGETTDVVQKEMYTFEDKAGRSITLKPEGTSPAVRAFVEGRLFNETQPTKMYYFTPVMRYENVQKGRLRQHHQFGIEIFGAKDASVDAEVISIPVGIYKELGVEGVELNINSIGCPKCRKTYNEALKKYLSKNYDKLCSTCKTRFDKNPLRILDCKVDTCKEIVKDAPIILDYICGECKEHFESLKNYLDVLNINYKIDPFIVRGLDYYSKTVFEFITDDITICAGGRYDYLIEEIGGPSMPAVGFGMGMERLLLTLQEKAIEIPEEAYVDLYLGNMGDKAKLEVLKLAKELRDRHIKCEIDHMGKSVKAQMKYANRIGAKYSMVLGEEELNTGKATIKKMEDGQQIEVDIKDMDTLIKVFK
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GNAI1_PONAB
Sequence: MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSTCNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
What is the function of this protein?
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades.  The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state.  Signaling by an activated GPCR promotes GDP release and GTP binding.  The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal.  Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity).  Signaling is mediated via effector proteins, such as adenylate cyclase.  Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity).  The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane.  Required for normal cytokinesis during mitosis (By similarity).  Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity).
What are the official names of this protein?
Guanine nucleotide-binding protein G(i) subunit alpha-1, Adenylate cyclase-inhibiting G alpha protein.
What is the protein family that this protein belongs to?
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex. Membrane; Lipid-anchor. Note=Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane.
Protein: SERC_SHEON
Sequence: MSAIYNFCAGPAMLPAAVMKKAQQELLDWNGLGVSVMEVSHRGKEFIALTKQAEADLRELMHIPQNYHVLFMHGGGRGQFSAVVNNFLGNQGRALYLVSGQWSSAALAEAQKLAGDAQIDSLNIVEKHNCLNAVVLPDLHKIDADYRYVHYCPNETVDGIEIFDELDSPWPIVADLSSTIMSREIDVSRYGLIYAGAQKNIGPSGLSIVIVRDDMLTLPSLPQSSIMDYRLAVEHDSMFNTPPTFAWYLAAEVFAWLKSIGGVASIAKINQQKAQMLYACIDANPFYKNGVVAANRSQMNVTFQLADESLDGAFLKEAEAVGLVALKGHRIVGGMRASLYNAMPLEGVAALVTFMNEFAAKHYNI
What is the function of this protein?
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
What are the official names of this protein?
Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_CHLTE
Sequence: MTSHRKLILASQSPRRRELLAMTGIPFETASVEIDETFDPVLTAEENVMEISKQKAEAVLRSISADEACAVVLGSDTTVVLDGKPLGKPGDFDHAFDMLSTLQGRSHEVLTGFCILHNGKAITDYARTIVEIGPMTPREITRYIEVMKPFDKAGSYGIQDPLLACFVTGIDGCYYNVVGLPVSKVYAALKPLFPAEG
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNC_CUPTR
Sequence: MNLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLYGMFGKLDEGDLSRVRANLVKQQALYEIAQMLQLSDTLRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFDAARALIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYNVIATHGAAHSQQFEVECTVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTRKQPQPQDPQLSLRLKE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YOD4_CAEEL
Sequence: MNADKFVETTISDFMRLNSSRDFEYFVSIAKQLYSRGCRDYYTEAFLTHLKTIFPITEENAEKWLKYGEMLGTVGEKDFRTDIFEQMMKDFVDSNKLSQIAAKFHGFVESVDDWNLLAECLFSRVRALEHKINLTASAPMATDPSESSC
What are the official names of this protein?
Uncharacterized protein ZC262.4.
Protein: IF1C_ANTMA
Sequence: MKEQKWIHEGLITESLPNGMFRVRLDNEDLILGYVSGKIRRSFIRILPGDKVKIEVSRYDSTRGRIIYRLRNKDSKD
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FLK_SALTY
Sequence: MHPISGAPAQPPGEGRNPLSAASEQPLSMQQRTVLERLITRLISLTQQQSAEVWAGMKHDLGIKNDAPLLSRHFPAAEQNLTQRLGVAQQNHANRQVLSQLTELLGVGNNRQAVSDFIRQQYGQTALSQLTPDQLKNVLTLLQQGQLSIPQPQQRPATDRPLLPAEHNTLNQLVTKLAAATGESNKLIWQSMLELSGVKSGELIPAKQFTHLATWLQARQTLSLQHAPTLHTLQAALKQPLEPDELTAIKEYAQHTYQIQPQTVLTTAQVQDLLNHIFLRRVEREADELEPLSIQPIYRPFAPMIETVKNLSARPGLLFIALIIVLALFWLVS
What is the function of this protein?
Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation.  Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system.  Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB.
What are the official names of this protein?
Flagellar regulator flk, Fluke.
What is the protein family that this protein belongs to?
Belongs to the flk family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ZN547_HUMAN
Sequence: MAEMNPAQGHVVFEDVAIYFSQEEWGHLDEAQRLLYRDVMLENLALLSSLGCCHGAEDEEAPLEPGVSVGVSQVMAPKPCLSTQNTQPCETCSSLLKDILRLAEHDGTHPEQGLYTCPAHLHQHQKEQIREKLSRGDGGRPTFVKNHRVHMAGKTFLCSECGKAFSHKHKLSDHQKIHTGERTYKCSKCGILFMERSTLNRHQRTHTGERPYECNECGKAFLCKSHLVRHQTIHSGERPYECSECGKLFMWSSTLITHQRVHTGKRPYGCSECGKFFKCNSNLFRHYRIHTGKRSYGCSECGKFFMERSTLSRHQRVHTGERPYECNECGKFFSLKSVLIQHQRVHTGERPYECSECGKAFLTKSHLICHQTVHTAAKQCSECGKFFRYNSTLLRHQKVHTG
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 547.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TSAD_ECO81
Sequence: MRVLGIETSCDETGIAIYDDEKGLLANQLYSQVKLHADYGGVVPELASRDHVRKTVPLIQEALKESGLTAKDIDAVAYTAGPGLVGALLVGATVGRSLAFAWDVPAIPVHHMEGHLLAPMLEDNPPEFPFVALLVSGGHTQLISVTGIGQYELLGESIDDAAGEAFDKTAKLLGLDYPGGPLLSKMAAQGTAGRFVFPRPMTDRPGLDFSFSGLKTFAANTIRDNGTDDQTRADIARAFEDAVVDTLMIKCKRALDQTGFKRLVMAGGVSANRTLRAKLAEMMKKRRGEVFYARPEFCTDNGAMIAYAGMVRFKAGATADLGVSVRPRWPLAELPAA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLAK_METM6
Sequence: MIEYIIGALGLIIASVQDFRSREIEDYIWIFLAVFGVLFAIYSSITLLDYSILINSISGFVICFILGYMMFLSGIGGGDGKMLIGLGALVPKFQMPIYTSLGTLLNLNYVPTFPIMVFINGIFFMVFLPFVILFRNILNGARPKTGKEFILMFFGEKMKVNVAKEQKRLIMGQNDKINFFPAADDEDFSKYSNNEEIWVTPQIPLIIPITLSYLVTPIIGDRILDFLIPF
What is the function of this protein?
Cleaves the N-terminal leader peptide from preflagellins.
What are the official names of this protein?
Preflagellin peptidase, PFP.
What is the protein family that this protein belongs to?
Belongs to the peptidase A24 family. Archaeal preflagellin peptidase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CLPP_DESPS
Sequence: MNLIPMVVEQTPRGERSYDIYSRLLKERIIFLGSGVNDDVANVIVAQLLFLEAEDPEKDITFYINSPGGSVTAGMAIYDTMQYIKCDIATLCMGQAASMGAVLLAAGTAGKRYALPNSRIMIHQPLGGFQGQATDIEIHTKEILRIRKDLNNILAHHTGKTLKKIESDTERDNFMSSVEAQKYGLIDEVLVKREDVEGAADNG
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TAT_BIV29
Sequence: MPGPWVAMIMLPQPKESFGGKPIGWLFWNTCKGPRRDCPHCCCPICSWHCQLCFLQKNLGINYGSGPRRRGTRGKGRRIRRTASGGDQRREADSQRSFTNMDQ
What is the function of this protein?
Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication.  Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts.  Tat binds to a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) in a CCNT1-independent mode.  Tat then recruits the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation.  The CDK9 component of P-TEFb hyperphosphorylates the C-terminus of RNA Pol II that becomes stabilized and much more processive (Probable).
What are the official names of this protein?
Protein Tat, S ORF, Transactivating regulatory protein, bTat.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus.
Protein: XKS1_EMENI
Sequence: MSSRSSSPLKGPLYIGFDLSTQQLKGLVVNSDLKVVYSSIFDFDADSQGFPIKKGVLTNEAEHEVFAPVALWLQALDSVLDGLKKQGLDFSHVRGISGAGQQHGSVYWGQDAEKLLNGLDAGKRLQEQLEGAFSHPYSPNWQDSSTQKECDEFDEYLGGADKLAEATGSKAHHRFTGPQILRFQKKYPDVYKKTSRISLVSSFLASLFLGHIAPLDISDVCGMNLWNIHKGAYDEDLLKLCAGPHGVEDLKRKLGDVPEDGGIDLGKVHRYYVDRYGFSPECTVIPSTGDNPATILALPLRPSDAMVSLGTSTTFLMSTPSYKADPATHFFNHPTTPGLYMFMLCYKNGGLAREKIRDAINDAKNEKNPSNPWANFDSVALQTPPLGQTSPSDPMKMGLFFPRPEIVPNLRAGQWLFNYDPSTGNLTETLNGEGWNRPADEARAIIESQMLSLRLRSRGLTSSPGGDIPAQPRRVYLVGGGSKNKTIAKIAGEILGGSEGVYKLEIGDNACALGAAYKAVWALERKKDQTFEDLIGARWHEEEFIEKIADGYQKEAFERYGKAVEGFEKMEQRVLEQEGRK
What is the function of this protein?
Highly specific D-xylulose kinase which participates in the catabolism of xylose.  Xylose is a major component of hemicelluloses such as xylan.  Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).
What are the official names of this protein?
Probable D-xylulose kinase A, Xylulokinase A.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAZ_CLOB8
Sequence: MFIGEYQHALDPKNRIIVPAKLRDGLGNKFVITKGLDGCLYAYPLDEWRILEDKLKTLPLTNKDARSFVRFFFSGACEVELDKQGRGLIPQNLKEYAGIEKDIVSIGVLSRVEIWSKEKWSEYNESNIDFDSIAEKMNDLGI
What are the official names of this protein?
Transcriptional regulator MraZ.
What is the protein family that this protein belongs to?
Belongs to the MraZ family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: HIS4_THEPX
Sequence: MVLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHLVNGNIIEQIIKSCKAEIEVGGGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNYGERTIVGIDSKNGEVAVSGWLEKTKIKDMELAKKMKEIGVKTIIFTDISKDGTLNGPNFKALENILKTGVQVIASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSALEVI
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEX1_NEUCR
Sequence: MGYYDDDAHGHVEADAAPRATTGTGTGSASQTVTIPCHHIRLGDILILQGRPCQVIRISTSAATGQHRYLGVDLFTKQLHEESSFVSNPAPSVVVQTMLGPVFKQYRVLDMQDGSIVAMTETGDVKQNLPVIDQSSLWNRLQKAFESGRGSVRVLVVSDHGREMAVDMKVVHGSRL
What is the function of this protein?
Major component of Woronin bodies, fungal-specific organelles that occlude septal pores in order to separate intact from damaged compartments (PubMed:11273682, PubMed:10783241).  Hex-1 binds directly or indirectly to the Woronin body tether that in turn is anchored at the rim of the septal pore (PubMed:11273682, PubMed:10783241).
What are the official names of this protein?
Woronin body major protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family. Hex1 subfamily.
What are the subcellular locations of this protein?
Cell septum. Note=Localizes at Woronin bodies, fungal- specific organelles that plug the septal pore in case of physical damage.
Protein: MIAB_RENSM
Sequence: MTLTVSPQESAHQQDESVTPRTYEVRTYGCQMNVHDSERMAGLLERSGLVKAEGKVADVVVFNTCAVRENADNKLYGNLGMLAPAKEANPGMQIAVGGCLAQKDRDTILKRAPWVDVVFGTHNVGALPTLLERARHNEEAQLEILESLDVFPSTLPTKRDAVYSGWVSISVGCNNTCTFCIVPSLRGKEKDRRPGDILAEIQALVEDGAIEVTLLGQNVNSYGVEFGDRQAFSKLLRACGEIEGLERVRFTSPHPAAFTEDVIEAMAETHNVMPQLHMPLQSGSDKVLKDMRRSYRSSKFLGILDKVRTQIPDAAISTDIIVGFPGETEEDFQATLDVVAKSRFATAFTFQYSKRPGTPAADLPDQLPKAVVQERFERLTALQDQISAEENARQIGREVELMVTAGSGKKAAETQRLSGRAKDSRLVHFAVPEGEETPRPGDLVTVTITEAASFHLVADPLPGSVYRLRRSRAGDAWDLAQAEFCGVPNGAQGTSDGGKSSVSLGMPTIPVLPAR
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYXC_CROOH
Sequence: MKILYLLFAFLFLAFLSEPGNAYKRCHKKGGHCFPKTVICLPPSSDFGKMDCRWKWKCCKKGSVNNAISI
What is the function of this protein?
Cationic peptide that possesses multiple functions.  It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor.  It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity).
What are the official names of this protein?
Myotoxin, Crotamine-4, Toxic peptide C.
What is the protein family that this protein belongs to?
Belongs to the crotamine-myotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NGDN_HUMAN
Sequence: MAALGVLESDLPSAVTLLKNLQEQVMAVTAQVKSLTQKVQAGAYPTEKGLSFLEVKDQLLLMYLMDLTHLILDKASGGSLQGHDAVLRLVEIRTVLEKLRPLDQKLKYQIDKLIKTAVTGSLSENDPLRFKPHPSNMMSKLSSEDEEEDEAEDDQSEASGKKSVKGVSKKYVPPRLVPVHYDETEAEREKKRLERAKRRALSSSVIRELKEQYSDAPEEIRDARHPHVTRQSQEDQHRINYEESMMVRLSVSKREKGRRKRANVMSSQLHSLTHFSDISALTGGTVHLDEDQNPIKKRKKIPQKGRKKKGFRRRR
What is the function of this protein?
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.  Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (PubMed:34516797).  Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (By similarity).
What are the official names of this protein?
Neuroguidin, Centromere accumulated nuclear protein 1, CANu1, EIF4E-binding protein.
What is the protein family that this protein belongs to?
Belongs to the SAS10 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Chromosome, centromere. Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell projection, filopodium. Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). Translocated from nucleolus to nuclear foci in response to UV damage.
Protein: USPA_YERPE
Sequence: MAYKHILIAVDLSPESKVLVEKAVSMAKPYNAKVSLIHVDVNYSDLYTGLIDVNLGDMQKRISEETHNALTELSQNAGYPVEQTLSGSGDLGQVLVDAIKKYDIDLVLCGHHQDFWSKLMSSARQLINTVHVDMLIVPLRDDENGEDD
What is the function of this protein?
Required for resistance to DNA-damaging agents.
What are the official names of this protein?
Universal stress protein A.
What is the protein family that this protein belongs to?
Belongs to the universal stress protein A family.
What are the subcellular locations of this protein?
Cytoplasm.