PharMolix/UniProtQA huggingface dataset:
Protein: APOE_TUPGL
Sequence: MKVLWAVLAFAFLTGCRADVEPQLEPEVREPPKWQAGQPWELALGRFWDYLRWVQTLSDQVQEELLSSQVTQELTVLMEETMKEVKAYKAELEEQLGPMKEETQARLSKELQAAQARLGADMEDVRTRLAQYRSEVHTMLGQSTEELRARLSSHLRKMRKRLLRDAEDLQKRLAVYRAGVQEGAERGVSAIRERLGPLMEQGRLRANTVSALAVQPLQERAQAWGERLRGRLQEVGSQARDRLDEVREQVEEVRAKVEEQATQMRLQAEAFQARLQSWFEPLVKDVQRQWAELVEKVQAAVGTSAAPVSSENH
What is the function of this protein?
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids.  APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance.  Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma.  As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL).  It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles.  Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
What are the official names of this protein?
Apolipoprotein E, Apo-E.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans- dependent manner. Lipidation induces the release from the extracellular matrix.
Protein: FABZ_YERPG
Sequence: MTTDTHTLHIEEILDLLPHRFPFLLVDRVLDFEEGKFLRAVKNVSFNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSRGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVEFVKERRGLTRFTGVAKVDGEIVCTATMMCARSKPAAPAESVVVKPDVVKPDVVNPVVKES
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFR3_CRYNJ
Sequence: MGCIPCRTLQPEVAHLNACYPPPKALLTAGPEYRPLAQDLSKLTYFATNKPSKLAKIGEELEKRVAQESARASSGNHKYRASLLISLAILRALLTECKRDIALFARSTLRVIDSSLDVRVYQRGGIDLEVVGRAAAAFIAYTTYTDGSAVGVDDTLTKTYFEILRKFGSMATVSLLDSSEKPDTEQQNRTRLIALAGLNGAATSDAIFASTRDFPRQIDLIIPPLLVNTFEGQISELKLESAKIGMDASPSPFFSEFAAKGPVAQRRAPSLHAHIPGEKGPTSADVVSAALRSLHSLLQQCNVTQASQIIDRLVMFLDKHGWQYAERDCFVAEQVTAWIPLQYRFIVPTRLVEVLMDLQDRTPTPKHTSALAMVTTILNSTTSLVGLGVTDLLQHLVSLIIRRIHFDLRDALLPSLVQCVSSLGTHIYYADQINDIVEELALRIAEIPSSDTARSEIIRVLTCCISGVMIMTDAADNDAESKQGNNVPQPTPSTPGSPTPPNKGKLPAPAETPFLTPLFEYLRPQAHRSSRRNPISPEVWQETLPLLCEADYSVRSTYARALILFLETEMQRGPTPRTTPASGGSGSETATPNREKGVSFKVTEPTPGETATQTQSGSGATTPPKRNSRSHRPSLPLNRLQSYTHLSSFDNVATPLDFAAALRILDAMHMVVPVAALVTGAPMLLAVDRDAGNELVRRPGDGRAGAWVLERKRAIRELVSLVWRRIADRWGIVEIDDLANKALASLPEPYLIPPYPVPDSPPVFLSLPEEPVSFIQHTLEGESSSTAKPLLDQDTLLDALVKSQTVQAAKQMDEAGLKRLFDGKWSVEQAIKDSMERFSSANLRPDDDSHYNAASALLMSMNNASYQSVNGQRLSRTIDVTDLRDALGGRVDTVSTSGAPSIASFDDSFHSQSAPRSSLQSRRMNKDSDVKEILKDIFKDKKKGTKAPKGIVVNRVKSASASEEARTSTGDENGLGMSGMTQGDGATGHKVVTNPPLDLSLGRPVDVSSSS
What are the official names of this protein?
Protein EFR3.
What is the protein family that this protein belongs to?
Belongs to the EFR3 family.
Protein: YIDC_STAAR
Sequence: MKKKTLLPLFLGIMVFLAGCDYSKPEKRSGFFYNTFVDPMKNVLDWLGNNLLNDNYGLAIIILVLVIRIILLPFMLSNYKNSHMMRQKMKVAKPEVEKIQEKVKRARTQEEKMAANQELMQVYKKYDMNPIKSMLGCLPMLIQLPIIMGLYFVLKDQLVDGLFKYPHFLWFDLGRPDIWITIIAGVLYFIQAYVSSKTMPDEQRQMGYMMMVISPIMIIWISLSSASALGLYWSVSAAFLVVQTHFANIYYEKVAKKEVQPFIEAYEREHNGGSNKKGKNTQVVSKKKKK
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FLGI_NITHX
Sequence: MPGVGISRIVRIAVAALVALAPLMTPAHATSRIKDLANIEGVRQNQLIGYGLVVGLNGTGDTLNNIPFTKQSLQAMLERMGVNIRGATIRTGNVAAVMVTGNLPAFATQGTRMDVTVSAMGDAKSLHGGTLLVTPLLGADGNVYAVAQGSLAIGGFAAEGAAASVTKGVPTNGRIANGAIVEREIEFALNKMPNVRLALRNGDFTTAKRIAAAVNDFLGTKTAEPIDPSTVQLSIPAEFKGNVVALLTEIEQLQVEPDTAAKIIIDERSGIIVMGRDVRVATVAVAQGNLTVSISESPQVSQPNPLSRGRTVVTPRTAVGVTEDGKKLALVKNGVSLQELVDGLNGLGIGPRDLIGILQAIKAAGAIEADIEVM
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: YCAD_SALTI
Sequence: MSIYTRPVMLLLCGLLLLTLAIAVLNTLVPLWLAQANLPTWQVGMVSSSYFTGNLVGTLFTGYLIKRIGFNRSYYLASLIFAAGCVGLGVMVGFWSWMSWRFIAGIGCAMIWVVVESALMCSGTSHNRGRLLAAYMMVYYMGTFLGQLLVSKVSGELLHVLPWVTGMILAGILPLLFTRIVNQQTQARHSSSISAMLKLRQARLGVNGCIISGIVLGSLYGLMPLYLKHQGMANASIGFWMAVLVSAGILGQWPMGRLADKFGRLLVLRVQVFVVILGSIAMLTQAAMAPALFILGAAGFTLYPVAMAWACEKVEHHQLVAMNQALLLSYTVGSLLGPSFAAMLMQNYSDNLLFIMIASVSFIYLLMLLRNVGQTPNPVAHI
What are the official names of this protein?
Uncharacterized MFS-type transporter YcaD.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TN13B_MOUSE
Sequence: MDESAKTLPPPCLCFCSEKGEDMKVGYDPITPQKEEGAWFGICRDGRLLAATLLLALLSSSFTAMSLYQLAALQADLMNLRMELQSYRGSATPAAAGAPELTAGVKLLTPAAPRPHNSSRGHRNRRAFQGPEETEQDVDLSAPPAPCLPGCRHSQHDDNGMNLRNIIQDCLQLIADSDTPTIRKGTYTFVPWLLSFKRGNALEEKENKIVVRQTGYFFIYSQVLYTDPIFAMGHVIQRKKVHVFGDELSLVTLFRCIQNMPKTLPNNSCYSAGIARLEEGDEIQLAIPRENAQISRNGDDTFFGALKLL
What is the function of this protein?
Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.
What are the official names of this protein?
Tumor necrosis factor ligand superfamily member 13B, B-cell-activating factor, BAFF.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.
Protein: RL10_PHOLL
Sequence: MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYIRVVRNTLIRRAVEGTAYECLKEAFVGPTLIAFSNEHPGAAARLFKEFAKANPAFEIKAAAFEGEFIPAANIDRLATLPTYEEAIARLMSTMKEAVAGKLVRTLAALRELREQKEVA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: APT_ALKCK
Sequence: MDYKQYITIVEDWPQEGIRFKDITTLMQNGTAYKRAVEELAVYAKEKQADVIVGPEARGFVVGCPIATELEIGFVPVRKKGKLPREVIEANYGLEYGKDCLTIHKDSIQPGQRVVITDDLLATGGTIEATAKMVEQLGGKVVGIAFLIELAYIGGRDKLKQYDLFSLMSYE
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EQXR_GIBF5
Sequence: MSTRNSQSIRSSCDRCRSHKLKCTVSPEDSRSGPHKCTRCIRAQVTCVFGPRSQSKRTPNGKNKPEKPKPELEPPQKTSPPVCSSSLAGMDLGSPGAWTPWIDDLASQETEEPLPIDVNTAGDGSGPSDGDFWADLGMTQELNMLELAPTNTYQAQYLASFDYVAPPVAEVGHLMDISEPSEHTPPHAIVQLSTLVTKIHETSKALEESPWSNVPDAKQLQNYPIGRVLSLSQDFCSILGCIWGKVSISSDGQSSGSGSSPTPSADMLDYAEVLSSIKITQDPTASSSMAASVDMPTALLVLSCYTSLIKLYSLVFAHFENHLSHLPEIPSPYPSQAALASHRWGLQLGELPSADETCTKICTAVQVLLDAFQSVEDVFGLPRSFSAVRQRTCDMEGMDFSAELGRTSLWTDYMVHFVVRSNAIRADTEECEEMRELSTKVRSLKALIREKMNL
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:28379186).  Directly activates expression of only the three biosynthetic genes PKS-NRPS1, DA and ER, while TF23 and MFS-T are induced by the final product trichosetin and not by TF22 (PubMed:28379186).
What are the official names of this protein?
Trichosetin biosynthesis cluster transcription factor TF22.
What are the subcellular locations of this protein?
Nucleus.
Protein: ACUG_ASPA1
Sequence: MSKTFEYVICGGGTVGCVLASRLSLAGHSVLLIEAGPEDYNDRIMSPVAAPHLHGTEWEHNLMTTKQPGLGNRSVPNYAGKLLSGSSGINYGLWTRGHSVDYDSWAKAVGDERWNYANMLKYFQKTETQISTTAAARIYPLREPIRNAMVAAGLDYNPDPNGGNPLGFGPFTENWKNALRQPASKAYDLSKATVLTNSVIARVDFDDPKTTATGVTLTDGTQYTATSEVLVTCGALKTPQLLMLSGIGPQQHLAQHNIPIIADLPVGENYHDKISATFFWKLRHPEKGYALGSPRFNKPEFRHGNPIEWVATVPTPHAELIKATQQDQIDSDDPYLQKPRGNVEVMVAYAPIAGGGSEFRLPMDGTHISSPVVLLLPTSRGRITLASADPTADPVLDPGYLDTETDRAAIRAGMRVALRLMETESAKEVIDGETPPPGHEPLTSACSDADLDRRVQIVGSSFFQNGGTAAMGTVVDTQCRVKGVRNLRVCDASVLSVPLAGHYQAPMYALGEAVADMLLAQ
What is the function of this protein?
GMC-type oxidoreductase; part of the gene cluster that mediates the biosynthesis of aculins (PubMed:26374386).  The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) acuA via condensation of acetate and malonate units (PubMed:26374386).  The 6-methylsalicylic acid decarboxylase acuB then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol) (Probable).  These first reactions occur in the cytosol (By similarity).  The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase acuC converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase acuD (Probable).  Gentisyl alcohol is further oxidized by the oxidoreductase acuE that probably catalyzes hydroxylation of the aromatic ring (Probable).  The aromatic system might then be opened by oxidation through a Baeyer-Villiger type of oxidation, which could be catalyzed by acuF, with the carboxylic acid at C-1 subsequently reduced to an aldehyde by acuG (Probable).  Subsequently, a hemiacetal is formed, before the dehydrogenase acuH would reduce the double bond between C-4 and C-6 (Probable).  Finally, keto-enol tautomerism results in formation of aculinic acid, which exists as two diastereomers (both R/S configurations at C-1) by non-enzymatic hemiacetal formation (Probable).  The carboxypeptidase acuI could be involved in the linking of aculinic acid to an aculene A moiety produced by the aculene biosynthesis cluster and which leads to the production of aculin A (Probable).  AcuI may also be involved in the attachment of proline to aculinic acid to form epi-aculins A and B (Probable).
What are the official names of this protein?
GMC-type oxidoreductase acuG, Aculin biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: PURA_STRS7
Sequence: MTSVVVVGTQWGDEGKGKITDFLSSDAEVIARYQGGDNAGHTIVIDNKKFKLHLIPSGIFFPEKISVIGNGVVVNPKSLVKELAYLHEEGVTTDNLRISDRAHVILPYHIKLDQLQEEAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDRDIFAERLKTNLAEKNRLFEKMYDSAPIAFDEIFEEYYGYGQEIKKYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREIGHEYGTTTGRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLETVKICVAYDLDGKRIDHYPASLEQLKRCKPIYEELPGWSEDITGVRSLEDLPENARNYVRRIGELVGVRISTFSVGPGREQTNILESVWATI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SPM1_SCHPO
Sequence: MDRRHRVYRVFNQEMYVEPNFKVVKELGQGAYGIVCAARNVASKDQEAVAIKKITNVFSKSILTKRALREIKLLIHFRNHRNITCIYDLDIINPYNFNEVYIYEELMEADLNAIIKSGQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLARGCSENPEENPGFMTEYVATRWYRAPEIMLSFSSYHKGIDVWSVGCILAELLGGTPLFKGKDFVHQLNLILHQLGTPDEETLSHISSSRAQEYVRSLPKQRPIPFETNFPKANPLALDLLAKLLAFDPNRRISVDDALEHPYLAVWHDPSDEPVCDSVFDFSFEYIEDANELRRVILDEVLNFRQKVRRRSHPTNPTVNIPQPAQTVPSNDNGSFNVSSSSSSQTSNKKRHDHSYNETAAIDHKSDDNRHN
What is the function of this protein?
Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2).  Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions.
What are the official names of this protein?
Mitogen-activated protein kinase spm1, MAP kinase spm1, MAP kinase pmk1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: Y1579_SULIN
Sequence: MSKKIINEVIDILEDKKYTYTMIEYPEHNRKSVDIVLNSKEPTLIRVSEDKVTKEEISDLKKIAVSTLTASLVVTNEEEEDIVSVKADNVFAVSPEGFKKVINGEKIFLYRTRGGIFIKIRNYILKHKREEMGYSIGDVAKFLGVSRKAIYDYEKGDSDVSLEVAEKLIDLFGDDIIGDVIWDSIKGKKEVIEEDITEFSPESFKSKLIYKLKENGLNILSLKLTAADLIVKDNENNRYLVTIENKDYNKSMKKFYEAKKLSSYTKSELLIIIRTSKMLKECEDLGYKTYEENDIHSLIDEIKGSNGRQS
What are the official names of this protein?
Putative HTH-type transcriptional regulatory protein YN1551_1579.
Protein: NDK_STAHJ
Sequence: MERTFLMIKPDAIQRNLVGEIISRIERKGLKLVGAKLMTVPQALAEEHYSEHTDKPFYGKLISFITSAPVFAMVVEGEDAVDVSRHIIGKTNPSEATPGSIRGDLGLTVGRNVIHGSDSVESAQREINLWFKEEELSSYEAPRDTWLYE
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y139_DESA1
Sequence: MELSRVLDNEVKLRNAIYLLMSIVNDTAVPRNIRRAATEALNYLRDERYTPGVRAANAVGVLDQVSQDPNMPLSARTKVWQVIAILETIHD
What are the official names of this protein?
UPF0147 protein DKAM_0139.
What is the protein family that this protein belongs to?
Belongs to the UPF0147 family.
Protein: PSMG3_NEMVE
Sequence: MAAAIDGSLPVCRQSAALIDGVHTDFLASWYSDRILVLVTQFQKFGTLVSVTRDQPVARPDQAQGGTDSHTFTTKVLMGDDLPIWHVYGQQIFKAINGEDGCKPVLVAIALQNHSPEILKCILGQLESIRQVQTP
What is the function of this protein?
Chaperone protein which promotes assembly of the 20S proteasome.  May cooperate with psmg1-psmg2 heterodimers to orchestrate the correct assembly of proteasomes (By similarity).
What are the official names of this protein?
Proteasome assembly chaperone 3.
What is the protein family that this protein belongs to?
Belongs to the PSMG3 family.
Protein: PURT_PSEPF
Sequence: MTRIGTPLSPTATRVLLCGCGELGKEVVIELQRLGVEVIAVDRYANAPAMQVAHRSHVINMLDGAALRAVIEAEKPHFIVPEIEAIATATLVALEAEGFTVIPTARAAQLTMNREGIRRLAAEELDLPTSPYHFADTFEDYSKAVQDLGFPCVVKPVMSSSGKGQSLLRSADDVQKAWDYAQEGGRAGKGRVIIEGFIDFDYEITLLTVRHVGGTTFCAPVGHRQEKGDYQESWQPQAMSPVALAESERVAKAVTEALGGRGLFGVELFIKGDQVWFSEVSPRPHDTGLVTLISQDLSQFALHARAILGLPVPLIRQFGPSASAVILVEGQSTQTAFANLGAALSEPDTALRLFGKPEVNGQRRMGVALARDESIEAARAKATRASQAVVVEL
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: ILVD_STRP4
Sequence: MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKDIDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRAVVKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGVKVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNMDKSGKK
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: AMPA_SYMTH
Sequence: MKVEVTSQALTEVAVDVLILPLTEGTPAPADVNEALGGLCAQVVGADFKGEMGQTTLLYTGGRLPARKVLLLGLGKAEKVTNRSLRRAAGIGARAARKSGARSIAFALPGAVEMDEAAAARFITEGALHGLFRLPDWKSEKKPRPEVEAVHILGGERAREGAEHGRIVAEGVNLARALAWTPGNHLTAAKLAERAAEMCRENGIEVEVYDKKGCEELGLGLLLAVNQGSREEPRFIVMRYKGNGGQGPWLGLVGKGLTFDSGGISIKPTEGMWNMKMDMGGAAAVIGAMQAIARLKVKADVMAVIPSTDNMPDGGSYKPGDVVSGLSGKTVEIRSTDAEGRLILADGLAYAAKQGCRKIITASTLTGACNIALGPIRYALVANDDAWEEEVYRAGEAAGERGWKLPHDEEYYDLIKSSVADMINGTKNRAAGTVAGGLFLMKHVGDTPCVHLDIAAVAWKSGSDEYEDEGATGVGTRTFVEAARRFAEGLR
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURL_RHILW
Sequence: MTIPNTIPITPELIAGHGLKPDEYQRILDLIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTKGPRVIQGPGENAGVVDIDDGDCVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGEPDHPKTRHLVSGVVSGVGGYGNSFGVPTVGGEVEFDARYNGNILVNAFAAGIAKSNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDESIEEKRPTVQVGDPFTEKCLLEACLELMQTGAVIAIQDMGAAGLTCSAVEMGAKGDLGILLELDKVPVREERMTAYEMMLSESQERMLMVLQPEKEQEAKAIFVKWGLDFAIVGKTTDDLRFRVMHQGEEVANLPIKDLGDQAPEYDRPWRESGKQAPLPANLVAAPKDYGQALLQLVGSANQSSRRWVYEQYDTLIQGNSLQLPGGDAGVVRVDGHPSKALAFSSDVTPRYVEADPFEGGKQAVAECWRNITATGAEPLAATDNLNFGNPEKPEIMGQFVQAVKGIGEACRALDFPIVSGNVSLYNETNGVAILPTPTIAGVGLLPDWRKMARIGSANDGDKVIMIGVDGSHLGQSVYLRDVLDSREGPAPEVDLFAERRNGDFVRSVIRNGQATACHDISSGGLAVALAEMVMASDKGLAIDLGEGKGAPHALLFGEDQARYVLTVPADVADFLCANAEGAGVPFRRLGTVGGTALTVGDLISLPIQQLRDAHESWFPDFMEGRGELAAE
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLLC1_MACLB
Sequence: MGRFISVSFGLLVVFLSLSGTGADFDCPSDWVSYDQHCYKAFNDLKNWTDAEKFCTEQNKGSHLVSLHSSEEEDFVVNLASQSLQYPVAWIGLGNMWKECRSEWSDGGNVKYKALAEESYCLLINTHKKGWRSMTCNNMAHVICKF
What is the function of this protein?
Regulatory subunit of the blood coagulation factor X-activating enzyme.  Activates coagulation factor X (F10) by cleaving the Arg-Ile bond at position 234, activates coagulation factor IX (F9) by cleaving the Arg-Val bond at position 226 and is also able to activate protein C (PROC).  May serve as an exosite by which the enzyme recognizes and binds to the Gla domain of factor X (F10) in a calcium-dependent manner.
What are the official names of this protein?
Snaclec coagulation factor X-activating enzyme light chain 1, VL factor X activator light chain 1, VLFXA light chain 1.
What is the protein family that this protein belongs to?
Belongs to the snaclec family.
What are the subcellular locations of this protein?
Secreted.
Protein: HCAD_ECO57
Sequence: MKEKTIIIVGGGQAAAMAAASLRQQGFTGELHLFSDEQHLPYERPPLSKSMLLEDSPQLQSVLPAHWWQENNVHLHSGVTIKTLGRDTRELVLANGESWHWDQLFIATGAAARPLPLLDALGERCFTLRHAGDAARLREVLQPERSVVIVGAGTIGLELAASATQRRCKVTVIELAATVMGRNAPPPVQRYLLQRHQQAGVRILLNNAIEHVVDGEKVELTLQSGETLQADVVIYGIGISANDQLAREANLDTTNGIVIDEACRTCDPAIFAGGDVAITRLDNGALHRCESWENANNHAQIAAAAMLGLPLPLLPPPWFWSDQYSDNLQFIGDMRGDDWLCRGNPETQKAIWFNLQNGVLIGAVTLNQGREIRSIRKWIQSGKTFDAKQLTDENIALKSL
What is the function of this protein?
Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively.
What are the official names of this protein?
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family.
Protein: YCY1_EUGLO
Sequence: MVFICLYFEVHGIYNKNEKLFDRIYCNSNGHILEVCRKLKTQDFWFSEFGDKPYYFFSNKVSTYCKIGGNDIGEFEYYLLDIFLYGPLKFKVNDIYDFNMIGALERRQRYSEMIEREKKNKNKFKIVFYFFQKKYKLLLENRFLVKERLTTKNNLIVYIWYW
What are the official names of this protein?
Uncharacterized protein in rps2-rps9 intergenic region, ORF162.
What is the protein family that this protein belongs to?
Belongs to the A.longa ORF167/ORF288 family.
What are the subcellular locations of this protein?
Plastid.