PharMolix/UniProtQA huggingface dataset:
Protein: XAF1_HUMAN
Sequence: MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQQVGCTMCQQSMQKSSLEFHKANECQERPVECKFCKLDMQLSKLELHESYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMIPENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSINRFPLHSESSSKKAPRSKNKTLDPLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILLPLPILNQHQEKCRWLASSKGKQVRNFS
What is the function of this protein?
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family.  Inhibits anti-caspase activity of BIRC4.  Induces cleavage and inactivation of BIRC4 independent of caspase activation.  Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells.  May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway.  After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria.  Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm.  The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4.  Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL.  May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
What are the official names of this protein?
XIAP-associated factor 1, BIRC4-binding protein.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment. SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. SUBCELLULAR LOCATION: [Isoform 5]: Nucleus.
Protein: DBP5_YARLI
Sequence: MSDQVSDMLEKLELQKEKNQAAATEAKVEEVKEDDKKDVKEELNEDDKKVAKEDDKKEDAKEESKEDAEENNLIQTEYEVRVKLADLQADPNSPLYSAKRFEDLGLDENLLKGLYAMKFNKPSKIQEKALPLLLSDPPHNMIGQSQSGTGKTGAFSLTMLSRVDPNLKAVQCICLAPSRELARQTLDVVDEMKKFTDITTHLIVPESTERGQKVTSQILVGTPGSVAGLLQKKQIDAKHVKVFVLDEADNMVDSSMGSTCARIKKYLPSSTQVVLFSATFPESVLDLAGKMCPNPNEIRLKANELNVDAITQLYMDCEDGEEKFKMLEELYSMLTIASSVIFVAQRSTANALYQRMSKNGHKVSLLHSDLSVDERDRLMDDFRFGRSKVLISTNVIARGIDIATVSMVVNYDLPTDKNGKPDPETYLHRIGRTGRFGRSGVSISFVHDEASFEVLDSIQQSLGMTLTQVPTDDIDEVEEIIKKAIKGK
What is the function of this protein?
ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus.  May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex.  May also be involved in early transcription (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DBP5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.
Protein: NU2M_RABIT
Sequence: MNPLTLIIIMFTLFMGTMITVFSSHWLTMWIGLEMNMLAIIPILINKATPRSTEAATKYFLTQATASMILMMAITLNILDSGQWTLINPQNQLTPVLITLALIIKLGMAPFHFWVPEVTQGVPLKSGLILLTWQKLAPLSILYQISPSINPTMMMSVAILSIMVGGWGGLNQTQLRKILAYSSIAHMGWMAAIITFNPNTMVLNLIIYILMTIPMFMMFMQHSSTTTLSLSQMWNKNPLMVSTILITLMSLGGLPPLTGFIPKWIIIQELTKNGNIILPTAMAMLALLNLYFYMRLIYSSSLTMFPTTNNLKMKWQFESTKRMPLITPLIILSTMLLPLTPALSVLN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GIS2_YEAST
Sequence: MSQKACYVCGKIGHLAEDCDSERLCYNCNKPGHVQTDCTMPRTVEFKQCYNCGETGHVRSECTVQRCFNCNQTGHISRECPEPKKTSRFSKVSCYKCGGPNHMAKDCMKEDGISGLKCYTCGQAGHMSRDCQNDRLCYNCNETGHISKDCPKA
What is the function of this protein?
May act in the sexual differentiation pathway.
What are the official names of this protein?
Zinc finger protein GIS2.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DF181_ARATH
Sequence: MERIPSLASLVSLLIIFATVVNQTRASICNDRLGLCDGCDQRCKAKHGPSCESKCDGPVGMLLCTCTYECGPTKLCNGGLGNCGESCNEQCCDRNCAQRYNGGHGYCNTLDDFSLCLCKYPC
What is the function of this protein?
Confers broad-spectrum resistance to pathogens.
What are the official names of this protein?
Defensin-like protein 181, Low-molecular-weight cysteine-rich protein 80, Protein LCR80, Plant defensin 3.1.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: FPRB_MYCTO
Sequence: MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCGACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPVTPAAEVRVRRQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPYGLVRSGVAPDHQNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAHHHAVLYAVGAPDDRRLTIDGMGLPGTGTATELVAWLNGHPDFNDLPVDLSHERVVIIGNGNVALDVARVLAADPHELAATDIADHALSALRNSAVREVVVAARRGPAHSAFTLPELIGLTAGADVVLDPGDHQRVLDDLAIVADPLTRNKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQRRAGGVQFSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVIDPGTGEPVPGAYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDPVATPTALDQLVQARQPQAIGCAGWRAIDAAEIARGSADGRVRNKFTDVAEMLAAATSAPKEPLRRRVLARLRDLGQPIVLTVPL
What are the official names of this protein?
Probable ferredoxin/ferredoxin--NADP reductase, FNR.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ferredoxin--NADP reductase family.
Protein: END4_ACHLI
Sequence: MLILGSHVSLKGNDMFYGSVLEALEYNANTMMVYTGAPQNTIRKPIETMKIEEAHALMKEKGIDLNHVVVHAPYIINLCNPDPERRAFAVEFLTKEVIRVGQMGINQMVLHPGSAVGGNREEAVQWISEGLNQIIDNTKSYNVRIALETMAGKGNEIGKTFEEIKAIIDGVDDKSRVSVCFDTCHVHDAGYDVIHDLDKTLQLFDDIVGLNYISVVHVNDSKNELGASKDRHENIGFGYIGYDALLKVIYHEAFKEIPKILETPYVNDKPPYKLEIQMIKDRVFDNELKTKLEK
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: PYRG_STRPF
Sequence: MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESRDVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVDNAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEGANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRSEFEAAGFVFSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PER_BERVA
Sequence: SKSSTGTPPSYNQLNYNENLMRFFKSKPVTVGKEESMAVEQSYNDVELQRDPSPDQCCDYSGESGSAGNLSSGSNVQMEIITNGSNTGTGTSSGSFQPPLLTEALLN
What is the function of this protein?
Essential for biological clock functions.  Determines the period length of circadian and ultradian rhythms; an increase in PER dosage leads to shortened circadian rhythms and a decrease leads to lengthened circadian rhythms.  Essential for the circadian rhythmicity of locomotor activity, eclosion behavior, and for the rhythmic component of the male courtship song that originates in the thoracic nervous system.  The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex.  Light induces the degradation of TIM, which promotes elimination of PER.  Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop.  Behaves as a negative element in circadian transcriptional loop.  Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
What are the official names of this protein?
Period circadian protein.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with Tim is required for nuclear localization (By similarity).
Protein: LGT_BACCZ
Sequence: MLLGSVPQLDRVAVQLGPFPVYWYGIIIGTGVLLGLWLATREGERLGIPKDTFVDLVLIAVPIAILFARMYYVIFEWEYYAQNPSQIINIRQGGLAIHGGLIGAVITGILFAKRRGVSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGDEVTRQFLEGLHLPDFIINQMYIDGVYYHPTFLYESLWNFAGVILLLALRKVNLRRGELFFTYLIWYSIGRFFVEGLRTDSLMLGPLRIAQVMSIGLVVISIIFIIVRRKMGQADKRYSEN
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y844_ARCFU
Sequence: MEKFIESVANFIDEEDVKVLKAIGSDPIVLHSIKKIFDYPEKANKYLILLRDSPVAVYLVAKISERLSRYLEGEDEAKCFAVFLTALRELRECGDRRVLQNMFLLLKEAIERRLSDGKYEDAAKLVMEFQDFGFKSYVKKVLFFALEVSEEGDYRRAMRILELLPETDAVIDAKASVLLEWGRSLAMSNPEAGMKKIEESLRLKDTVEARLAMAEIHESMGNYEKAYFIYTSLRSLYPGIDRRIARMLMEWGEEIGDVEKLREAYNLAMGDRLLAEEIERRIKKLEAQRLSGS
What are the official names of this protein?
Uncharacterized protein AF_0844.
Protein: CH102_RHOPA
Sequence: MNFRPLHDRVVVKRIDAEEKTAGGIIIPDTAKEKPSQGEIVAVGPGGRDEAGKLIPIDLKVGDRVLFGKWSGTEVKIDGKELLIMKESDIMGVITDVGAKKKAA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES 2, 10 kDa chaperonin 2, Chaperonin-10 2, Cpn10 2.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IGF2_HUMAN
Sequence: MGIPMGKSMLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTPPTVLPDNFPRYPVGKFFQYDTWKQSTQRLRRGLPALLRARRGHVLAKELEAFREAKRHRPLIALPTQDPAHGGAPPEMASNRK
What is the function of this protein?
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion.  Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
What are the official names of this protein?
Insulin-like growth factor II, IGF-II, Somatomedin-A, T3M-11-derived growth factor.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPE_PSEA7
Sequence: MAITVHCDIVSAEAEIFSGLVEMVIAHGALGDLGIAPGHAPLITDLKPGPIRLVKQGGEQEVYYISGGFLEVQPNMVKVLADTVVRAGDLDEAAAQEALKAAEKALQGKGAEFDYSAAAARLAEAAAQLRTVQQLRKKFGG
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CADI_MYCTO
Sequence: MSRVQLALNVDDLEAAITFYSRLFNAEPAKRKPGYANFAIADPPLKLVLLENPGTGGTLNHLGVEVGSSNTVHAEIARLTEAGLVTEKEIGTTCCFATQDKVWVTGPGGERWEVYTVLADSETFGSGPRHNDTSDGEASMCCDGQVAVGASG
What are the official names of this protein?
Cadmium-induced protein CadI.
What is the protein family that this protein belongs to?
To B.subtilis YqcK.
Protein: GLMS_ACIAD
Sequence: MCGIVGGVAERNIAEILIEGLKRLEYRGYDSAGVALINQQQILRERRVGKVANLAEAVAQSKISGSLGIAHTRWATHGKPTENNAHPHTSGSVAVVHNGIIENYQELKDDLEALGYVFTSQTDTEVVAHLINHAMTEQHNLLDAVREVVPELKGAYALGIIHTDYPDELITVREGSPLVIGVGIGENFISSDQLALLPVTNRFVYLEEGDIARLTRDSIEIYAHGVKIERPVKELDASVSNASKGEYKHYMLKEIYEQPEAIQQTISQALNGNALREDFLQFAEADFNQIQNVQIIACGTSYHAGMIAKYWFEQLIGVPCQVEIASEFRYRSPVIVANTLYICISQSGETADTLAALRDTQKRAKAKDIQISTLTICNVATSSMVRETDHHLLTLAGPEIGVASTKAFTTQLAALMLLILKIGQVKEQIAAEQIAEIASQLWHCPKVMLDTLQHNAEILRLSELFVEKQHCLFLGRGTHYPIALEGALKLKEISYIHAEGYAAGELKHGPLALVDNEMPVVILAPHDDMLDKLKSNMEEVQARGGELFVFADENSGVREKDRQHVVLIPEVNAWLAPIVYSIPVQLLSYHVAVLRGTDVDQPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CX5BL_ARATH
Sequence: MIRLDKEYSGRRLLDIDHPESPFGTKESPAVVQSYFDKRNIGCRGGEGEDGHDVVWFWLDKGKSFECPVCSQYFEHGPPDGHGDDEDHHH
What are the official names of this protein?
Putative cytochrome c oxidase subunit 5b-like.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 5B (TC 3.D.4.11) family.
Protein: NOX_BOMMO
Sequence: SMIGGVMSKG
What is the function of this protein?
NADPH oxidoreductase.  Has antiviral activity against BmNPV.
What are the official names of this protein?
NADPH oxidoreductase, BmNOX.
Protein: PG085_VAR67
Sequence: MIVLPNKVRIFINDRMKKDIYLGISNFGFENDIDEILGIAHLLEHLLISFDSTIFLANASTSRSYMSFWCKSINSATESDAIRTLVSWFFSNGKLKDNFSLSSIRFHIKELENEYYFRNEVFHCMDILTFLSGGDLYNGGRIDMIDNLNIVRDMLVNRMQRISGSNIVIFVKRLGPGTLDFFNQTFGSLPACPEIIPSSIPVSTNGKIVMTPSPFYTVMVKINPTLDNILGILYLYETYHLIDYETIGNQLYLTVSFIDETEYESFLRGEAILQISQCQRINMNYSDDYMMNIYLNFPWLSHDLYDYITRINDDSKSILISLTNEIYTSIINRDIIVIYPNFSKAMCNTRDTQQHPIVVLDATNDGLIKKPYRSIPLMKRLTSNEIFIRYGDASLMDMITLSLSKQDISLKRNAEGIRVKHSFSADDIQAIMESDSFLKYSRSKPAAMYQYIFLSFFASGNSIDDILTNRDSTLEFSKKTKSKILFGRNARYDVTTKSSFVCGIVRGKLLDKTSLVEMMWDLKKKGLIYSMEFTNLLSKNTFYLFTFTIYTDEVYDYLNTNKLFSAKCLVISTKGDVENFSSLKKDVVIRV
What is the function of this protein?
Probably involved in maturation of some viral proteins by processing them preferentially at Ala-Gly-|-Ser/Thr/Lys motifs.  Does not seem to be responsible for the cleavage of major core proteins.
What are the official names of this protein?
Metalloendopeptidase OPG085, Metalloendopeptidase G1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M44 family.
Protein: YEAH_ECOLC
Sequence: MTWFIDRRLNGKNKSMVNRQRFLRRYKAQIKQSISEAINKRSVTDVDSGESVSIPTEDISEPMFHQGRGGLRHRVHPGNDHFVQNDRIERPQGGGGGSGSGQGQASQDGEGQDEFVFQISKDEYLDLLFEDLALPNLKQNQQRQLTEYKTHRAGYTANGVPANISVVRSLQNSLARRTAMTAGKRRELHALEENLAIISNSEPAQLLEEERLRKEIAELRAKIERVPFIDTFDLRYKNYEKRPDPSSQAVMFCLMDVSGSMDQSTKDMAKRFYILLYLFLSRTYKNVEVVYIRHHTQAKEVDEHEFFYSQETGGTIVSSALKLMDEVVKERYNPAQWNIYAAQASDGDNWADDSPLCHEILAKKLLPVVRYYSYIEITRRAHQTLWREYEHLQSTFDNFAMQHIRDQDDIYPVFRELFHKQNATAKD
What are the official names of this protein?
UPF0229 protein YeaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: IL6_BUBCA
Sequence: MNSRFTSAFTPFAVSLGLLLVMTSAFPTPGPLGEDFKNDTTPGRLLLTTPEKTEALIKRMVDKISAMRKEICEKNDECESSKDTLAENKLNLPKMEEKDGCFQSGFNQAICLIRTTAGLLEYQIYLDYLQNEYEGNRENVRDLRKNIRTLIQILKQKIADLITTPATNTDLLEKMQSSNEWVKNAKIILILRNLENFLQFSLRAIRMK
What is the function of this protein?
Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability.  Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF.  Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity).  'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis.  Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity).  Also acts as a myokine (By similarity).  Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity).  Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity).  Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
What are the official names of this protein?
Interleukin-6, IL-6.
What is the protein family that this protein belongs to?
Belongs to the IL-6 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NIFJ_RHORT
Sequence: MSVRKMVAIDGNEACASVAYRVSEVAVIYPITPSSTMGELSDEWSAKGLTNIWGAVPQVVEMQSEGGAAGACHGAIQTGSLGTTFTASQGLLLMIPNMYKIAGELTPFCMHVTARTLATHALSIFGDQSDVMACRQTGFAILASASVQEAHDLASVAHGASLESRIPFLHFFDGFRTSHEVNKIELMTDDDLHAMIDDDLVAAHRARALTPDTPVTRGTAQNPDTFFQAQEARNPFYDACPAIVQSYMDRLAALTGRRYGLFDYVGHPQAERVVVIMGSGAETVAETVDWLVARGEKIGVVKVRLFRPFSVDAFVAALPVSVRAIAVLDRCKESGAIGEPLYLDVVGALARAKALGLRAGIVDPAVIGGRYGLSSKEFTPAMVKAIFDELAKANPKQAFTVGIEDDVTHLSLSVDRSFRIESADIKRSVFFGLGADGTVGANKNSIKIISDSPTIHGQGYFVYDSKKSGAITISHLRFGPRPIRAPYLIDEADFIACHHFSFLDKVDVLETAAVGATLLLNSPHDKDTVWDALPRPVQQTIIDRDLKLFVIDANKVAQETGMGQRINTIMQTCFFALSGVMPRDEAIEEIKKAISKTYARKSQKVIDANFAAVDQTLSRLQSVTIPGVLTGHALPPLVSAGAPDFVRNVTAVMLAGKGDSLPVSAMPVDGTWPTETARWEKRDIAQQVCSWDADLCIQCNKCVMVCPHAALRVKAVPAEAAAALPASMNSTPYKGKDDLKGSAYVLALSPEDCTGCGICVEACPGKDKATGARSLTMHAREDVVSACKENWEIFLDLPDVARTSLRPTVKNSQFMTPLFEFSGACQGCGETPYLKLLTQMWGDRLMIANATGCSSIYGGNLPTSPYAKDANGRGPAWSNSLFEDNAEFGLGFRLALDQHRSEAKRLLGALAPQLSGVLVDGLVANAANNDEAAIAAQRERVVSLRAELGGLTGWQARALEGLADYLVEKVVWIVGGDGWAYDIGYGGLDHVISSGRNVNILVMDTEVYSNTGGQQSKSTPIGASAKFSVAGKALPKKDLGQIAMANGHVYVASIAFGASDNQTLRALSEAVSYEGPSLIIAYSHCIAHGYDLTCGLSQQKLAIETGYWPLYRFDPRKMGVGPALSLDGVQPSRPIGDYMANEGRFRIIRDADPERYAMLLEAAEENVRSRWALLRQLAGVADEQEGARAAQ
What is the function of this protein?
Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin, which reduces nitrogenase.
What are the official names of this protein?
Pyruvate-flavodoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
Protein: FBID_MYCMM
Sequence: MSGIRADGTGDVGLIIAVKRLGAAKTRLAPVFSAAARESVVLAMLMDTLTAAARVGDLRSITVITPDESAAAAATELGAEVLADPTRQGDPDPLNNAILTAEQVVSGSVPNIVVLQGDLPAMQTQELADAICAARAHQRSFVADRLGTGTAALCAFGSALDPQFGPDSSARHRRSGAVELTGAWPGLRCDVDTPADLAAARSLGVGPATARVVAHHR
What is the function of this protein?
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP.  It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
What are the official names of this protein?
Phosphoenolpyruvate guanylyltransferase, PEP guanylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the CofC family.
Protein: IF5_MAIZE
Sequence: MALQNIGASNRDDAFYRYKMPRMITKIEGRGNGIKTNVVNMVDIAKALARPASYTTKYFGCELGAQSKFDEKTGISLVNGAHDTAKLAGLLEVFIKKYVQCYGCGNPETEILISKTQMISLKCAACGFVSDVDMRDKLTTFILKNPPEQKKGGKDKKAMRRAEKERLKEGEAADEEQKKLKKDAKKKGSKDSTAKGLKKKATTATGSDEDHSSSPTRSHDGDKAAADDDDDDVQWQTDTSIEAAKQRMQEQLSAATAEMVMLSTEETEKKMKQPTHKDGSTNGSAKEIPNDKPAVTKPSPYEELIGDIKASLGSAPTPSQLKAVLASSTLPPQDVMNAPLEALFGGVGKGFTKEVVKNKKYLAVAVPDEGAQTLLVQAIEAFGGKCNPEALKEVPVVLKALYDGDILDEETIVDWYNDAVAAGKDSQVVKNAKPFVEWLQSAESDEEGDDE
What is the function of this protein?
Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S. mRNA. Met-tRNA[F]. eIF-2. GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide.  The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S. mRNA. Met-tRNA[F]).
What are the official names of this protein?
Eukaryotic translation initiation factor 5, eIF-5.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: TRIB1_HUMAN
Sequence: MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYLSPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC
What is the function of this protein?
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596).  The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797).  Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596).  Binds selectively the recognition sequence of CEBPA (PubMed:26455797).  Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity).  Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity).  Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
What are the official names of this protein?
Tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, GIG-2, SKIP1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Protein: LYTN_STAA8
Sequence: MFVYYCKECFIMNKQQSKVRYSIRKVSIGILSISIGMFLALGMSNKAYADEIDKSKDFTRGYEQNVFAKSELNANKNTTKDKIKNEGAVKTSDTSLKLDNKSAISNGNEINQDIKISNTPKNSSQGNNLVINNNELTKEIKIANLEAQNSNQKKTNKVTNNYFGYYSFREAPKTQIYTVKKGDTLSAIALKYKTTVSNIQNTNNIANPNLIFIGQKLKVPMTPLVEPKPKTVSSNNKSNSNSSTLNYLKTLENRGWDFDGSYGWQCFDLVNVYWNHLYGHGLKGYGAKDIPYANNFNSEAKIYHNTPTFKAEPGDLVVFSGRFGGGYGHTAIVLNGDYDGKLMKFQSLDQNWNNGGWRKAEVAHKVVHNYENDMIFIRPFKKA
What is the function of this protein?
Probably involved in peptidoglycan hydrolysis.
What are the official names of this protein?
Probable cell wall hydrolase LytN.
What are the subcellular locations of this protein?
Secreted.
Protein: ANMK_XANOM
Sequence: MPVLEHVDSLLYLGLMSGTSADGIDAALVRFAEDTHRRCELVAGTTVAWEPQLRETLVALGQGAETVAIDALGQLDAQVGLAFAAAANQLIRDSGVERRRIRAIGSHGQTIRHRPEADPAFTWQIGDASRIAEHTGITTVADFRRRDVAAGGQGAPLMPAFHLAMLGAGDQDSAVLNLGGIGNLTLIPRDGAVLGFDTGPANALLDSWCQRHHGTPFDAEGAFAASGRVDAALLQALLADPWFALPPPKSTGREQFHLDWVLQAMGSARLDAADVQATLLELTAASVADALLRLQPSTRRVLVCGGGVRNPVLLARLAARLPGVVVESSARYGLDPDYLEAMGFAWLAAELLAGRAANLPSVTGAAGPRLLGAIYPA
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.