PharMolix/UniProtQA huggingface dataset:
Protein: UREG_ALKEH
Sequence: MKDKPALRVGIGGPVGSGKTALVEALCKALRDHYEIAVVTNDIYTREDAEFLTRNGALPADRIIGVETGGCPHTAIREDASMNLAAVGDLNQRFPELEVVFIESGGDNLSATFSPELSDLTLYVIDVCAGDKIPRKGGPGITRSDLLVINKIDLAAGVGASLEVMDRDSRRMRGDRPFIFTNLHAGEGLESVIDFIIREGMLDRKPGLAPA
What is the function of this protein?
Facilitates the functional incorporation of the urease nickel metallocenter.  This process requires GTP hydrolysis, probably effectuated by UreG.
What are the official names of this protein?
Urease accessory protein UreG.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZTF30_CAEEL
Sequence: MKLEDDKIHSPTNTEEEGYGSDVEVENGTDISGSKGGSGVELKRPDLKGSFRCSICSKVFCHSSSLSRHRMQAHFKSYKCTVCRKDISSSESLRTHMFKQHHISRMYMCRCCNWAFPDKSLLHIHLQTATNNNDSNNNNNSVIPHGVINRSCHLITDPFQLIRTPLLNLPTPQSLESSVPSLPIASIPIPALQSPIRSQPQTPSWLANLPKPIPTTAPIFVADSKEKIKDEVEKPDVYTSQSPTCSSVSFKSDLSAFHQLCSDRALISSPLIDTASPSSSSSSSRISPRHECFDCHVSRTKILISENKCKLLEHKIGTMQQESLEANAQMNGLEQTVLRLRMEAHALREHNELFQRKLLECQNLAVKFLQNDKAHDASEMNSFLRILINNTILTRPF
What are the official names of this protein?
Zinc finger transcription factor family protein 30.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL32_BOVIN
Sequence: MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRITNPNARLRSEENE
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL32 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGA_PSYIN
Sequence: MQKFDTKTFQGLILALQDFWARQGCAIVQPLDMEVGAGTFHPQTFLRSIGPEPMNSAYVQPCRRPTDGRYGENPNRLQQYYQFQVVLKPSPKNIQDLYLKSLEEIGIDTSIHDIRFVEDNWESPTLGAWGLGWEIWLNGMEVTQFTYFQQVGGLECSPVTGEITYGLERIAMYVQGVESIYDLVWTDGPMGKLTYGDIFHQNEVEQSSYNFEHADVDALFNQFNQCEKDSQKLIEAGLALPAYEQVMKASHAFNLLDARHAISVTERQRYILRVRALSKAVAEAYYGKREALGFPLCKNLVK
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF122_HUMAN
Sequence: MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLKGHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVSYNPITHQLASCSSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYLALGMFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSRWESFWMNRENEDAEDVIVNRYIQEIPSTLKSAVYSSQGSEAEEEEPEEEDDSPRDDNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISYFTKGEYILLGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCKELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEKIIKKFECNLLVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGLLVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTCLVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQKLQGFVVGYNGSKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIACLGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRGETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHGWVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLVQLHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKAGRQREAVQVLEQLTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTMLGKFYHFQRLAELYHGYHAIHRHTEDPFSVHRPETLFNISRFLLHSLPKDTPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPARFQKSIELGTLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSYDVLHLVEFYLEEGITDEEAISLIDLEVLRPKRDDRQLEIANNSSQILRLVETKDSIGDEDPFTAKLSFEQGGSEFVPVVVSRLVLRSMSRRDVLIKRWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRRCKDDPGP
What is the function of this protein?
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (PubMed:27932497, PubMed:29220510).  Involved in cilia formation during neuronal patterning.  Acts as a negative regulator of Shh signaling.  Required to recruit TULP3 to primary cilia (By similarity).
What are the official names of this protein?
Intraflagellar transport protein 122 homolog, WD repeat-containing protein 10, WD repeat-containing protein 140.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to photoreceptor connecting cilia.
Protein: ATG7_PICPA
Sequence: MTSMDIPYSQISSFVNSSFFQKVSQLKLNKYRLDDTDKAIVGSVDFKFIGKNQPTSLSVDESSFNDNITYTHAQFPVKGILKNLNTVEDFRKVDKNEFLQSQGLVVHKSIQDRSCLKDLSKLTQFFILSFSDLKGFKFIYWFGFPSLVSRWKVNKLSGLTESQIEPYESKLNEWLNARLPIEQKQAFIIDNLEFKPFEQLSSFSPDDQLNIGFIDTSSILNKCSTQLRNILYMLAYYGFENIKVYNFRFNNTTSFTLDITLAEPLTSEPKTTGWERTAQGKLGPKLADIGALVDPARLADQSVDLNLKLMKWRVMPELDLDIIKNSKVLLLGAGTLGSYVSRVLLGYGVRHITFVDNGKVSFSNPVRQPLFNFTDCLEGGAPKAETAAKALKLIFPLITSQGYNLEVPMAGHPVTDEKRQYEDYQRLVTLIKEHDVVFLLMDSRETRWLPTVLCNVFDKICITAALGFDSYLVMRHGNLFNTEHIEAEENSHRLGCYFCNDIIAPKDSTTDRTLDQMCTVTRPGVALLASSLAAELFVSILQHPLKSHAPASLHDNATVLGCLPQQLRGFLHNFETSKLEANNYEYCSACSIQVLNEYKSRTWDFVKDALNENNYLEDLTGLTKVKQESEIAEKKFQEFENGLEFSDEDSEWIN
What is the function of this protein?
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy.  Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine.  Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.  Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).  Involved in glucose-induced micropexophagy.
What are the official names of this protein?
Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, Glucose-induced selective autophagy protein 7, Pexophagy zeocin-resistant mutant protein 12.
What is the protein family that this protein belongs to?
Belongs to the ATG7 family.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: PYRR_THET2
Sequence: MRFKAELMNAPEMRRALYRIAHEIVEANKGTEGLALVGIHTRGIPLAHRIARFIAEFEGKEVPVGVLDITLYRDDLTEIGYRPQVRETRIPFDLTGKAIVLVDDVLYTGRTARAALDALIDLGRPRRIYLAVLVDRGHRELPIRADFVGKNVPTSRSEVVKVKVEEVDGEDRVELWEREGA
What is the function of this protein?
Probably regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.  In contrast to pyr attenuation in Bacillus, PyrR from Thermus could act as a translational repressor: the binding of PyrR at its proposed recognition site in the transcript would prevent initiation of translation of the leader peptide, resulting in terminator formation and reduced expression of downstream genes (By similarity).  Also displays uracil phosphoribosyltransferase activity (By similarity).
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: RSBW_STAAS
Sequence: MQSKEDFIEMRVPASAEYVSLIRLTLSGVFSRAGATYDDIEDAKIAVSEAVTNAVKHAYKENNNVGIINIYFEILEDKIKIVISDKGDSFDYETTKSKIGPYDKNENIDFLREGGLGLFLIESLMDEVTVYKESGVTISMTKYIKKEQVRNNGERVEIS
What is the function of this protein?
Negative regulator of sigma-B activity.  Phosphorylates and inactivates its specific antagonist protein, RsbV.  Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).
What are the official names of this protein?
Serine-protein kinase RsbW, Anti-sigma-B factor, Sigma-B negative effector RsbW.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: GAG_AVISU
Sequence: MEAVIKVISSACKTYCGKTSPSKKEIGAMLSLLQKEGLLMSPSDLYSPGSWDPITAALSQRLMVLGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGGGRVSPPGPECIEKPATERRIDKGEEVGETTVQRDAKMAPEETATPKTV
What are the official names of this protein?
Core protein p19, Gag protein p19.
What are the subcellular locations of this protein?
Virion.
Protein: G3PC1_ORYSJ
Sequence: MGKIKIGINGFGRIGRLVARVALQSEDVELVAVNDPFITTDYMTYMFKYDTVHGQWKHSDIKIKDSKTLLLGEKPVTVFGIRNPDEIPWAEAGAEYVVESTGVFTDKEKAAAHLKGGAKKVVISAPSKDAPMFVCGVNEDKYTSDIDIVSNASCTTNCLAPLAKVIHDNFGIIEGLMTTVHAITATQKTVDGPSSKDWRGGRAASFNIIPSSTGAAKAVGKVLPDLNGKLTGMSFRVPTVDVSVVDLTVRIEKAASYDAIKSAIKSASEGKLKGIIGYVEEDLVSTDFVGDSRSSIFDAKAGIALNDNFVKLVAWYDNEWGYSNRVIDLIRHMAKTQ
What is the function of this protein?
Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.  Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic, PP38.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AQP7_BOTFB
Sequence: MNINEPRDGGGFVLPFFNDSKKSRKSHAGRDSLKSNRVPFTKWVPDTVSYTTKPLKNAHRWLHLHNKTRNHFVATVAEFAGTTLFLFFAFSGTQVALLATPANDSNVVGTPSNPAQLLYVSLCFGFSLAVNAWVFFRISGGLFNPAVTMGMCIVGALPYFRGLLLIFAQIIGGIAAAAIVSALFPGPITFRTSLGGGTSIVQGLFIEMFLTAELVFTIFMLAAEKHKGTFIAPIGIGLSLFIAELTGVYFTGGSVNPARSFGPSVVSGQFTGYHWIYWVGPILGAILASAFYKFIKMLEYETANPGQDAGRVGEVIDPEAQAIKNRVSFASEGLVGRELDESGASHVHENGNHFGAPKEYGTKRRPFSDSPAPPNANDQFAGLSEGGLHTDEFANENIGGGHSGEGAMHRNKRDSEGTLVGNGKKGVLKVGAGGTGGAAVGSTNENLRDNTHNN
What is the function of this protein?
Water channel required to facilitate the transport of water across membranes (Probable).  Involved in conidiation (PubMed:26527167).
What are the official names of this protein?
Aquaporin-7.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein: YICS_ECOUT
Sequence: MKPTMLLMITVFLIFPAISQAESPFSSLQSAKEKTTVLQDLRKICTPQASLSDEAWEKLMLSDENNKQHIREAIVAMERNNQSNYWEALGKVECPDM
What are the official names of this protein?
Uncharacterized protein YicS.
Protein: PSD_RHOJR
Sequence: MARKPTPPGTQQPTSVGHILDLVRGAVPPLHPAGLPFVLAPLGVAVLGRKRKWVRRGALTSAAACAAFFRHPHRVPPNRVGVVVAPADGEVALVDSAVPPAELDMGTEPLPRVSIFLSVLDVHVQRSPVGGEVTKVVHRPGQFLSADLADASEVNERNSMLLHTPEGHDVAVVQIAGLLARRIVCDAKVGDTLPIGDTYGLIRFGSRVDTYFPAGTTLLAERGQRTIGAETVIAQLP
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HUTI_BACC0
Sequence: MLDTLLINIGQLLTMDQEDGLLRREAMNTLPVIENGAVGIENGVITFVGTAEEAKGLQAKEVIDCGGKMVSPGLVDPHTHLVFGGSRENEIALKLQGVPYLEILEQGGGILSTVNATKQASKEELVQKAKFHLDRMLSFGVTTVEAKSGYGLDDETEWKQLEATAQLQKEHPIDLVSTFLGAHAVPKEYKGRSKEFLQWMLDLLPEMKEKQLAEFVDIFCETGVFSVEESKEFLLKAKELGFDVKIHADEIDPLGGAEAAAEIGAASADHLVGASDKGIEMLANSNTVATLLPGTTFYLNKESFARGRKMIDEGVAVALATDFNPGSCPTENIQLIMSIAMLKLKMTPEEVWNAVTVNSSYAINRGDVAGKIRVGRKADLVLWDAYNYAYVPYHYGVSHVNTVWKNGNIAYTRGEQSWSTATI
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SP2AB_BACLD
Sequence: MKNEMNIQFTALSQNESFARVTVAAFIAQLDPTMDELTEIKTVVSEAVTNAIIHGYENSGQGNVYISVTLEDHIVYLTIRDEGVGIPNLEEARQPLFTTKPELERSGMGFTIMENFMDDISIDSSPEMGTTIHLTKHLSKSKALCN
What is the function of this protein?
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F).  Phosphorylates SpoIIAA on a serine residue.  This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
What are the official names of this protein?
Anti-sigma F factor, Stage II sporulation protein AB.
What is the protein family that this protein belongs to?
Belongs to the anti-sigma-factor family.
Protein: MURB_LACLS
Sequence: MIKETDLENIPDLLIKFNEPLSNYTYTKVGGPADILAFPATIEALTELSAKAKATDTPVTVLGNASNLIVRDGGIRGVVILLEKLDSVKVAGYTIEAQAGAKLKEVTQVAQANSLTGFEFACGIPGSIGGAVFMNAGAYGGEIYQVLVSCKVMDAAGNVSVLSASEMQFGYRHSVIRDKNLIVLSAKFELQAGDPTQIQNEMDRLNFLRESKQPLEYPSCGSVFKRPVGHFAGQLIQEAKLQGQRIGGVEVSKKHAGFMVNVADGNATDYEKLIALVIEKVKENSGVTLEPEVRIIGEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YIA1_YEAST
Sequence: MADKLMDKNFEELCYSCRTGDMDNVDRLISTGVNVNSVDKFDNSPLFLASLCGHEAVVKLLLQRGAVCDRDRYEGARCIYGALTDTIRDTLLSYDISKAVDVKQPFATHISSMYNDEGFLKRDITFRVSNGKLFTAHKFLLCARSEILAEKMVNEWAKHEIVSLEVRPDIFDIFLKFLYLIPILHQIEPGQYEELIELSSKFDIELLPEFLDKARHTADPTEKSRLMSDYQYKFTEVARSQLLIFVNNCIFRSTVDLANSERRVFSLMNCPAYPDVQLMVKNRNGAIRIYPCHLAVLSRAEYFKVMFTNNFKEKVTYIKAKHVTGKYNSIIPQLTLPNCEFEVAEIILRYLYADNTDIPWMYAVDVLLLADILLEDRLKTIASTIITQSKEFIQQYNVFDVLYLSWEIGVERLEQFAAKFIAIHLQELYKDPEIKRAIMLSSQRISLRQETDTIELVDDIRYYLLRKYSFEPDDVELFENQDDLEYLKQVGYLEYRKDMGMLDNILADLELDV
What are the official names of this protein?
Ankyrin repeat-containing protein YIL001W.
Protein: SYL_CLONN
Sequence: MGNYGTTVDEKWQKKWEESGLHNFDENAPGEKLYVLEMFSYPSAAKLHAGHWFNYGPTDSWARFKKMNGYNVFQPMGFDAFGLPAENFAIKTGIHPQDSTMKNIENMEEQLRSMGAMFNWDHEIITCLPDYYKWTQWVFLKLYEKGLAYRKNAPVNWCPSCNTVLANEQVLDGHCERCDSLVEKKALTQWFLKITDYADELLEKLDGLDWPEKTKAMQKHWIGKSKGVEATFKVENSDITFDVFTTRVDTLNGVTYVVLAPENELVDSLTTEENKAAVEAYKIEAQKQSDIERQSSTREKTGVFTGSYAINPINGNKVPIWVGDYVLATYGTGCVMAVPAHDERDYAFATKYDLPIVRVIEGGDSLPFTEYGSLVNSGEFDGLYGEEAKEAIVKKLQEQKLGNWKVNYRLRDWLVSRQRYWGAPIPVVYCDKCGTVAVPEEQLPVELPYNIEFTPDGKSPLSKSEEFLHTTCPKCGGHAVRETDTLDTFVCSSWYYLRYVDNNNSEKAFDIDKVNKMLPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFDEPFTSLTHQGLILGPDGLKMSKSKGNTIAPDDYIKEYGADVFRMYLMFGFAYSEGGAWSDDAIKSMSKFVDKVERILADSRTQMADSKNTKTTIEKAEKELNYTRHYAIQHVTEDTEKFQFNTAIARIMEYTNSLSKYLNEENLNVEFLKEALTDYIKLLAPFAPHFSEEQWELLGNTSSVFTTSWPKFDPKALVKDEVEIAIQILGKIKARMNIATNLTDEEIKEAALNNETIKGLLEGKNIIKVIVVKGSLVNIVAK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIG_SALTY
Sequence: MLRIADKTFDSHLFTGTGKFASSQLMVEAIRASGSQLVTLAMKRVDLRQHNDAILAPLIEAGVTLLPNTSGAKTAEEAIFAAQLAREALGTHWLKLEIHPDARWLLPDPIETLKAAEALVKQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETKAMLEIIIQQSTVPVVVDAGIGVPSHAAQALEMGADAVLVNTAIAVADDPVMMATAFRLAVEAGVLARQAVPGNRSTYANATSPLTGFLEALA
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHG07_BOVIN
Sequence: MARPLRAPLRRSFSDHIRDSTARALDVIWKNTRDRRLAEIEAKEACDWLRAAGFPQYAQLYEDLLFPIDISSVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSEDSDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDPIPGSPDAVHLKSAPSHENMQTDLSDRQEVASVHSTGSLTTHAPQRGEAAPARTNSVLSVCSSGTFVGNDDSFCSLPSPKELSSFSFSMKGHEKAAKSKTHSLLKRMESLKLKGSHHSKHKAPSKLGLIISGPILQEGVDEEKLKQLNCVEISALNGNHINVPMVRKRSISSSTQTSSSSSQSETSSNVSTPSPVTRTRSLSACNKRGGMYLEGFDPFNQSTFNNVMEQNCKNRESYPEDTVFYIPEDHKPGTFPKALSNGSFSPSGNNSSVNWRTGSFHGPGHISLRRENSSPKELKRRNSSSSVSSRLSIYDNVPGSILYSSSGDLADLENEDIFPELDDILYHVKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDNDRATPSDLDSTGNSLNEPEEPSDIPERRDSGVGASLTRSNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRNVFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNESTIDCVNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPLTLEALGRLCNDDSADYQHFLQDCVDSLFKEVKEKFKGWVSYSTSEQAELSYKKVSEGPPLRLWRATIEVPATPEEILKRLLKEQHLWDVDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPKGACALLLTSVDHDRAPVVGVRVNVLLARYLIEPCGSGKSKLTYMCRADLRGHMPEWYTKSFGHLCAAEVVKIRDSFSHQNTETKDTKSR
What is the function of this protein?
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling.  This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation.  Also functions in vivo as an activator of the phospholipase PLCD1.  Active DLC1 increases cell migration velocity but reduces directionality (By similarity).  Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85 (By similarity).  The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation (By similarity).
What are the official names of this protein?
Rho GTPase-activating protein 7, Deleted in liver cancer 1 protein homolog, DLC-1, Rho-type GTPase-activating protein 7, START domain-containing protein 12, StARD12, StAR-related lipid transfer protein 12.
What are the subcellular locations of this protein?
Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.
Protein: RSMG_EXIS2
Sequence: MNQQQFVTALAEQGLEVSDHQLQQFRKYYELLVEWNEKMNLTAITDEEGVYLKHFYDSITAAFYFDFTKVETVCDVGAGAGFPSLPIKIMFPHLKVTIIDSLNKRIGFLNMLATELGLEGVAFHHGRAEEFGKNKQFREHFDVVTARAVARMSVLAEYCLPLARVGGQFVALKAAKLGEELEEGATALKVLGGNLRESFQFQLPGEESERNIVIVDKKRLTPGKYPRKAGTPAKDPLG
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_CLOBB
Sequence: MKIKTLTVSDLTNYIKKVIDNDFILNNLSVKGEISNLKFHSSGHIYFSLKDNNSKVNCVMFKSKASLLNIALEDGMEVMVKGRASIYTATGSFQLYCDEIKKEGQGELFIKFEALKEKLSKSGYFDEKYKKNIPMYAKRIGIVTSSTGAVIRDIINVTKRRNSLVDIILYPAKVQGDNAYKEIIAGIEYFNKKKNIDIIIVGRGGGSIEELWNFNEEELAKVIFNSKLPIISAVGHEVDFTISDFVSDVRAATPSQAAEIAVPLLSDINTRIYEISKSLDYEIQKKLKDCKSRLESNERILKLHSPISKIVNSYLEIDKLKDRLYFAIDIKIKREKQKIESLNNLLSANNPIKVLNKGYAIIEDENNNIIKEISQLNEEKEISVSLSDGNIKGNFIPIK
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS5_CORU7
Sequence: MSERDRNGGRSADNNRNDRNERGGRNDRGGRNDRRNNQQDERNQYIERVVTINRVSKVVKGGRRFSFTALVIVGDGQGMVGVGYGKAKEVPAAIQKGAEEARKNFFRVPMINGTITHPVQGEAAAGVVMLRPAAPGTGVIAGGAARPVLECAGVQDILCKSLGSPNAINVVHATVAGLKELVRPEEVAARRGKSLEEVAPAAMLRARAAGQGA
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RS3_METM5
Sequence: MIERTFVGENVSETLIDEYFKTKLVRAGYSHIDLKKTPIGTRITVFAEKPGFVIGRKGKMVKELTETLAKEYAVKNPQIEVKQVENPDLDPAIVGHKIASSLERGMHFRRTAHSAIRRVMGSGAKGVSIIVSGKLSGERSRTEKFMDGYMKHCGEPAEALVNKSHQLAKLKLGVVGVTVKIMKPDVTLPDEITILSGEIKEVTEYSEASQE
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PNTB_ECOLI
Sequence: MSGGLVTAAYIVAAILFIFSLAGLSKHETSRQGNNFGIAGMAIALIATIFGPDTGNVGWILLAMVIGGAIGIRLAKKVEMTEMPELVAILHSFVGLAAVLVGFNSYLHHDAGMAPILVNIHLTEVFLGIFIGAVTFTGSVVAFGKLCGKISSKPLMLPNRHKMNLAALVVSFLLLIVFVRTDSVGLQVLALLIMTAIALVFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGTDGSSTGDDQEVGEHREITAEETAELLKNSHSVIITPGYGMAVAQAQYPVAEITEKLRARGINVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFADTDTVLVIGANDTVNPAAQDDPKSPIAGMPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKENTHMLFGDAKASVDAILKAL
What is the function of this protein?
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.
What are the official names of this protein?
NAD(P) transhydrogenase subunit beta, Nicotinamide nucleotide transhydrogenase subunit beta, Pyridine nucleotide transhydrogenase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the PNT beta subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NADK_BACTN
Sequence: MPILQPKLMKQLMKFAIFGNTYQPKKSLHALRLFELLKKQGAEICMCREFYQFLTADLKMEVPVDALLEGNDFTADMVISIGGDGTFLKAARRVGRKQIPILGINTGRLGFLADVSPEEMEVTFEEIQAGRYSVEERSVLQLICNDRNLQESPYALNEIAVLKRDSSSMISIRTAINGAYLNTYQADGLVIATPTGSTAYSLSVGGPIIVPHSNTIAITPVAPHSLNVRPIVIRDDWEITLDVESRSHNFLVAIDGSSETCKETTQLTIRRADYSIKVVKRFNHIFFDTLRSKMMWGADGRR
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECB2_FRAT1
Sequence: MDQQAQPQFQIQKVYVKDLSFSIPNSDKIWTTNWKPELHTDLKVEATKLPEENTYETVLTLEVKVENDGMVAFEAEVKQAGIFTVANMQEAQIEHAKKAFCPNILYHYAREAISDLVISGGFPQLCLSAVNFDAMYQDSLKESADSKQH
What is the function of this protein?
One of the proteins required for the normal export of preproteins out of the cell cytoplasm.  It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state.  It also specifically binds to its receptor SecA.
What are the official names of this protein?
Protein-export protein SecB 2.
What is the protein family that this protein belongs to?
Belongs to the SecB family.
What are the subcellular locations of this protein?
Cytoplasm.