PharMolix/UniProtQA huggingface dataset:
Protein: THIG_BRUMB
Sequence: MLEFYGKRFESRLLLGTAQYPSPSILADAVRASLSRIVTVSLRRESGEARAGQDFWALIKALGVAVLPNTAGCHTPREAITTAHMAREVFGTNWIKLEVIGDTDTLQPDPFGLVEAARILCDEGFEVFPYMNDDLIVAERLIEAGCKVLMPWGAPIGSGRGFNNPYALKTMRAHFPDIPLVVDAGIGVPSHAAAAMELGFDAVLINTAVAKAGDPAAMARAFALAVEAGRLAYEADPIEARDMASPSTPLLGKAFL
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAF_MSV36
Sequence: EKNKIRPRGQRDSSYYWKMEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAIKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSAPEPSLHRAAHTEDINACTLTTSPRLPVF
What are the official names of this protein?
Serine/threonine-protein kinase-transforming protein raf.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.
Protein: RS24_METST
Sequence: MEIKIIEKKENPLLNRTEIKFECEYPTEGTPTILDVKHKLVALEDSSNDLLVVDSMKPSYGVPTAFGLAKIYDSTESLAKIETKSVIAKNEEPEEEPEEEAEDAE
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: CH10_RICFE
Sequence: MSFKPLHDRIAIKPIEHEEKTKGGIIIPDTAKEKPMQGEIVAVGNGIRNKKGEIHPLELKIGDKVLYGKWAGTEIEIKGEKLIVMKETDVFGIIN
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: A20A3_HUMAN
Sequence: MKLFGFGSRRGQTAQGSIDHVYTGSGYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTLLVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAVYSESTSLAEKLLSHGAHIEALDKDNNTPLLFAIICKKEKMVEFLLKRKASSHAVDRLRRSALMLAVYYDSPGIVNILLKQNIDVFAQDMCGRDAEDYAISHHLTKIQQQILEHKKKILKKEKSDVGSSDESAVSIFHELRVDSLPASDDKDLNVATKQCVPEKVSEPLPGSSHEKGNRIVNGQGEGPPAKHPSLKPSTEVEDPAVKGAVQRKNVQTLRAEQALPVASEEEQERHERSEKKQPQVKEGNNTNKSEKIQLSENICDSTSSAAAGRLTQQRKIGKTYPQQFPKKLKEEHDRCTLKQENEEKTNVNMLYKKNREELERKEKQYKKEVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMKNDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFRYQQELNYLKAENTRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVEMSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQTQEMKEMYQNAEAKVNNSTGKWNCVEERICHLQRENAWLVQQLDDVHQKEDHKEIVTNIQRGFIESGKKDLVLEEKSKKLMNECDHLKESLFQYEREKTEGVVSIKEDKYFQTSRKTI
What are the official names of this protein?
Putative ankyrin repeat domain-containing protein 20A3, Ankyrin repeat domain-containing protein 20A3 pseudogene.
Protein: MEP4_TRIVH
Sequence: MHGLLLAGLLALPLNVFAHPTESHSSGVSRRAIDITSYRLPQISKYTKSDAVPKQDGESFTTSSTGDDNVSSGDYVTTATNWLKKTLPKATYRLVNDHYIGDSGIGHVHFRQTAHGIDIDNTDFNVNIGRDGKVFSFGNSFYDGEIPKANPMVKRDFSDPVNALHGAIQTLNLPVTAKPENVKAKPVEGKENFKFEGTSGALSDPKAQLVYLQKDGGLVLSWKVETDVGDNWLLTYVDANKNDQVHSVVDYVSAAEYQVYPWGINDPTEGNRTTIHLPWLKTLSTDWHIDGKGWYPTTRGNNAIAQENPTGHPEYENNYRPKSPLFIFKYPYSPAMTPPSSYRDASITQLFYTTNVYHDVLYILGFNEKAGNFQINNWNKGGVGGDFAILNSQDGSGVNNANFATPPDGQPGRMRMYTWNASTPERDGCFEAGIVIHEYTHGVSNRLTGGPENSRCLAALESGGMGEGWSDFFATAIRLKAGDTRATDYTMGEWASNRPNGIRKYRYSTSLTTNPHMYVDADGLTSVHAIGTIWASMLYELLWNLIDKHGKGDVTKIRPVLKNGVPTDGRHLAMKIVLDGMALQPCLPNFVQARDAILDADKNLTQGSNKCEIWKAFAKRGLGVGAAFNQTKRTGSNELPAGC
What is the function of this protein?
Secreted metalloproteinase probably acting as a virulence factor.
What are the official names of this protein?
Probable extracellular metalloproteinase 4, Fungalysin MEP4.
What is the protein family that this protein belongs to?
Belongs to the peptidase M36 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACYP_AZOC5
Sequence: MTHTLHLVIHGRVQGVGYRAWCADEAVSRGLSGFVRNRREGTVEAVISGPSEAVAAMLEACRSGPAHAHVERIEEALAEAPPAGTGFRVAATV
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: LIPA_CHLTE
Sequence: MNSGPGKKPDWLKIKLASGSSFASTRKLLNRHSLHTVCRSAMCPNLHECWSKGTATFLLLGNVCTRSCRFCAVGTECRPAMPDPEEPSKIAEAVKTMKLRHAVLTSVNRDDLADGGATHWVETIRAIREVNPGVSLECLIPDFSGNEQSLDLVMQELPEVLNHNIETVPSRYAAVRPQALYERSLAVIERAKRQFRLATKSGMMVGMGETEEELEASLHDLRGHGCDMVTIGQYLQPTAAHLPVSRYVTPEEFERYREIALDAGFRHVQSGPFVRSSYHAEAFEPVEKIS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_BRAHW
Sequence: MSNILDGRELAKEIKERIKKETEILEKKPRIDFLYFEDDKSTEVYFTRAKKQAESVGMIGSLHNLPVNTTEKDFLTLIEYLNEESETSGIMIQMPLPKHISKKKVYETISIEKDADAISHVNLGRIFIGDSNLAPCTAKSAMALIEKSGINIEGANAVVIGRSEIVGKPLAHLLLQKSATVTIAHSKTKNLKELCKNADILCVSIGKAEFITGEYIKEGAVVIDVGINVLEDGSLKGDVNFEEASKLASYITPVPNGVGSVTVSMLLDNVLYLHKNIINKK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: AC4_TPCTV
Sequence: MGNLISMCLYNSKGNSTAKINDSSTWYPQPGQHISIRTYRELNPAPTSTPTSTRTETLSNGENSRLTLDLLEEASRQLTTNVQRP
What is the function of this protein?
Pathogenicity determinant (By similarity).  May act as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs.
What are the official names of this protein?
Protein C4, Protein L4.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae protein AC4/C4 family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor. Note=Localizes to the cell periphery.
Protein: DSBB_LEGPA
Sequence: MKKLTYRKIQSFQAIITVLVIFASFYLEYAVGLQPCPLCLMQRVCVFILLGLMGLSLGTVKKAHIVSLMQFLVACAGLYFSLRQLWLQSLPSDQAPACMPGLDVLIQYFPWQTVAKALFWGAGDCAEVTWTMFGISMPGWAAMYFLFMAIMGLFLFFRTRTIN
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCM1B_XENLA
Sequence: MLEQVQKFLLSRAACQGSDSQSRYEELFHKLDVNKDGKVDILELQEGLKAMGMEVGKGAEEKIVAAGDTNKDGHLDFGEFIRYLEEHEKKMKIAFTSLDKNKDGKIESAEIMNSLKVLGIKISLDHADKILKSMDSDGTLTVDWNEWRDHFLFNPADNIQQIIRYWKHSTVLDIGDSLTIPDEFTEEEKKTGQWWKQLMAGGMAGAVSRTGTAPLDRLKVMMQVHGSKGNSNIITGLKQMVKEGGIRSLWRGNGVNVIKIAPETAMKFWAYEQYKKLFTSESGKLGTAERFVAGSLAGATAQTSIYPMEVLKTRLAVGRTGQYSGMFDCAKKIMQKEGIRAFYKGYIPNILGIIPYAGIDLAIYETLKNYWLQNHAKDSANPGVLVLLGCGTASSTCGQLASYPLALIRTRMQAQASIEGAPQLNMGGLFRKIVAKEGFLGLYRGIGPNFLKVLPAVSISYVVYEKMKVQLGI
What is the function of this protein?
Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane.  Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter.  By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways.
What are the official names of this protein?
Mitochondrial adenyl nucleotide antiporter SLC25A24-B, Small calcium-binding mitochondrial carrier protein 1-B, SCaMC-1-A, Solute carrier family 25 member 24-B.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RL32_RICPR
Sequence: MAVPKKKTSKSKRNMRRSHLALGKINVIVDSHTGEYKLPHHISLVDGTYNNRQVVTKKIDTEEVA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: ABSAB_ALCSP
Sequence: MDTVSIAEFLYTNADLLNQEQFDSWLEQCSNDFSYRITTFSEELGRPMDWMDKDKSGLAHYLQNANNHERYTGRLRRHLAMPRVTKQADSSFEVRTAVAIYVIEMNGETALYGIGSYVDNVMSESSGLRLTSRVVTLDTRRLQFGPHVPI
What is the function of this protein?
Beta subunit of the oxygenase component of the 2-aminobenzenesulfonate 2,3-dioxygenase system (deaminating) (ABSDOS).  Can use 2-aminobenzenesulfonate (ABS), benzenesulfonate (BS), 4-toluenesulfonate (TS), 2-nitrobenzenesulfonate, 3- and 4-aminobenzenesulfonates, 4-chloro- and 4-hydroxybenzenesulfonates and pyridine-3-sulfonate as substrates.  No desulfonation of ABS to aminocatechol or aminophenol detected.
What are the official names of this protein?
2-aminobenzenesulfonate 2,3-dioxygenase subunit beta, 2-aminobenzenesulfonate dioxygenase small subunit, AbsAb.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.
Protein: RS13_CAMJE
Sequence: MARIAGVDLPKKKRIEYGLTYIYGIGLFTSRKILDKVGISYDKRVHELSEDEAAAIRKEIQENYMVEGDLRKQVAMDIKALMDLGSFRGLRHRKGLPVRGQKTKTNARTRKGKRKTVGAKS
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: SLD7_YEAS2
Sequence: MSRKLCTLNFTLSGKQGSLVIRDIQLWSNRPTASKSTSELRGQFIQYVDLAKLPLWVRSTNMNTYRCYSTSATAQAYFKSKLRNANRGIVIELFDKVDQRSQEPAYLIIFRENTELNCFQVDLTMKHEFDGQVTKLKQEIGKTRASVSKEGSIDIIIQQSQQRKIGTKTKVYRNVHINDKRLQFNETLSKLILGGLRLRGISNSITDYQKLYKITFDAAEFTHRDELKRISMGSGEEVSFESLQETVETLLKLFTKS
What is the function of this protein?
Required for the proper function of SLD3 at the initiation of DNA replication.  Binds to SLD3 and reduces its affinity for CDC45, a component of the replication fork.  Required for mitochondrial morphology (By similarity).
What are the official names of this protein?
Mitochondrial morphogenesis protein SLD7, Synthetic lethality with DPB11-24 mutation protein 7.
What is the protein family that this protein belongs to?
Belongs to the SLD7 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle pole.
Protein: MTND_CHICK
Sequence: MVEAWYMDESQEDQRAPHRLQPNRAVSLEQLRRLGVAYRRLDADNYETDPRLKEIREAENYSWMDIVTIHKDKLPNYEEKIKTFYEEHLHLDDEIRYILDGSGYFDVRDKDDKWIRISMEKGDMITLPAGIYHRFTLDENNYVKAMRLFVGEPVWTAYNRPADDFPARKQYMKFLAEEAQ
What is the function of this protein?
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site.  Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway.  Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
What are the official names of this protein?
Acireductone dioxygenase, Acireductone dioxygenase (Fe(2+)-requiring), ARD', Fe-ARD, Acireductone dioxygenase (Ni(2+)-requiring), ARD, Ni-ARD, Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1, MTCBP-1.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
Protein: SYR_ECODH
Sequence: MNIQALLSEKVRQAMIAAGAPADCEPQVRQSAKVQFGDYQANGMMAVAKKLGMAPRQLAEQVLTHLDLNGIASKVEIAGPGFINIFLDPAFLAEHVQQALASDRLGVATPEKQTIVVDYSAPNVAKEMHVGHLRSTIIGDAAVRTLEFLGHKVIRANHVGDWGTQFGMLIAWLEKQQQENAGEMELADLEGFYRDAKKHYDEDEEFAERARNYVVKLQSGDEYFREMWRKLVDITMTQNQITYDRLNVTLTRDDVMGESLYNPMLPGIVADLKAKGLAVESEGATVVFLDEFKNKEGEPMGVIIQKKDGGYLYTTTDIACAKYRYETLHADRVLYYIDSRQHQHLMQAWAIVRKAGYVPESVPLEHHMFGMMLGKDGKPFKTRAGGTVKLADLLDEALERARRLVAEKNPDMPADELEKLANAVGIGAVKYADLSKNRTTDYIFDWDNMLAFEGNTAPYMQYAYTRVLSVFRKAEIDEEQLAAAPVIIREDREAQLAARLLQFEETLTVVAREGTPHVMCAYLYDLAGLFSGFYEHCPILSAENEEVRNSRLKLAQLTAKTLKLGLDTLGIETVERM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_SACEN
Sequence: MSVLVITGTGTEVGKTVVTAAIAALAPGRVAVLKAAQTGVAAGEDGDVAEVARLAGPVTAVELARYPEPLAPATAARRAGAPPVRPAQVAEAARELDREHDLVLVEGAGGLLVRYDDGGTLADVAVALSAPVLVVAHGGLGTLNAAALTAEALRARGVECAGVVVGSWPSAPDLACRCNLDDLPEVTGAPLLGVLPEGAAADPAAFGDIARAGLAPALGGRWSR
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_SALSV
Sequence: MPRRRVIGQRKILPDPKFGSELLAKFVNILMVDGKKSTAESIVYSALETLAQRSGKSELEAFEVALENVRPTVEVKSRRVGGSTYQVPVEVRPVRRNALAMRWIVEAARKRGDKSMALRLANELSDAAENKGTAVKKREDVHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: G3O21_WHEAT
Sequence: MPTPSHLSKDPRYFDFRAARRVPETHAWPGLHDHPVVDGSGAGGGPDAVPVVDMRDPCAAEAVALAAQDWGAFLLEGHGVPLELLAGVEAAIGGMFALPASEKMRAVRRPGDSCGYGSPPISSFFSKCMWSEGYTFSPANLRSDLRKLWPKAGHDYRHFCAVMEEFHREMRALADKLLELFLVALGLTGEQVAAVESEHKIAETMTATMHLNWYPKCPDPKRALGLIAHTDSGFFTFVLQSLVPGLQLFRHGPDRWVTVPAVPGAMVVNVGDLFQILTNGRFHSVYHRAVVNRDSDRISLGYFLGPPAHVKVAPLREALAGTPAAYRAVTWPEYMGVRKKAFTTGASALKMVAISTDNDAANDTDDLISS
What is the function of this protein?
Converts the inactive gibberellin precursors GA9 and GA20 in the bioactives gibberellins GA4 and GA1.  Accepts also GA15, GA44, the 2,3-unsaturated GA5 and 2,3-dihydroGA9 as substrate.  No activity with GA12, GA53, GA24, GA19 and GA25.  Possesses also 2-beta-hydroxylase, 2,3-desaturase, 2,3-epoxidase and 13-hydroxylase activities.
What are the official names of this protein?
Gibberellin 3-beta-dioxygenase 2-1, Gibberellin 3 beta-hydroxylase 2-1, Gibberellin 3-oxidase 2-1.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family. GA3OX subfamily.
Protein: RUXE_CAEBR
Sequence: MSQRKIQKVMVQPVNLIFRYLQNRTRVQIWLYEDVTHRLEGYIIGFDEFMNVVFDEAEEVNMKTKGRNKIGRILLKGDNITLIHAAAQEA
What is the function of this protein?
Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.
What are the official names of this protein?
Probable small nuclear ribonucleoprotein E, snRNP-E, Sm protein E, Sm-E, SmE.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol.
Protein: BRCC3_XENTR
Sequence: MAVQAVHIQGDAFLVCVTHSLSTEREEVMGLCIGEVDTQKVVHIHSVIILRRSDKRKDRVEISPEQLSAATTEADRLAEITGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDVGFVGLIFSCFIEDKNTKTGRILYTCFQSVQAQKSSEYERIEVPLHVVPHNTIRKVCLESAVELPRILCQEEQDAYRRIHSLGHLDSITKIHNGSVFTKNLCGQMSAISGPLLQWLEDRLEQNQQRAQELQSEKEQLLQELKALG
What is the function of this protein?
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains.  Does not have activity toward 'Lys-48'-linked polyubiquitin chains.  Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the rnf8-dependent ubiquitination at double-strand breaks (DSBs).  Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1.  Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression.  Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of nlrp3.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.
What are the official names of this protein?
Lys-63-specific deubiquitinase BRCC36, BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRISC complex subunit BRCC36.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. BRCC36 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Interaction with abraxas2 retains brcc3 in the cytoplasm.
Protein: YRBC_BACSU
Sequence: MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPEANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECVTDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLEAGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKLETLIDVLEDDDDVQEVYTNYRS
What are the official names of this protein?
Probable transcriptional regulatory protein YrbC.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSPB_DICD3
Sequence: MKNTPEVKASPQTGYRIPGYLLVVYALLLFTLGWFGHQRWADISPIPLSTSAAAIAAPPTKVGMVPASTAVTADENHPGSLHAAAENSATQTAASGSQTSASSQEATPDTKPAKLVTGWQTAKPGELPYIAFSAHVYTSAPDKRSVTLNGERYREGDSPYQGLVIEQIEQDMVIFSFNGEPFILDSLQDWPGGKPGDDAAQGNEQEPTSKPEQTVRTTKK
What is the function of this protein?
Out proteins are required for the translocation of pectate lyases and cellulases across the outer membrane.
What are the official names of this protein?
General secretion pathway protein B.
What is the protein family that this protein belongs to?
Belongs to the ExeB/OutB/PulB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: GELS2_LUMTE
Sequence: MSGLVKAKRYDWKDSNLAMFGSALDKSVKKESALKEAAWKGVGEKVGLKIWRIVNFKVTEWPEKDYGSFFSGDSYIILNTYKLKGREELAYDVHFWIGSKSTQDEYCVAAYKTVELDAYLDDAAIQHRDAEGNESDLFLSYFENGLTIMEGGAEMGFNNVKPEEYKARLLHFSGLKKHIVVKEVPLCPQRLKSDDVFILDLGRTLYQWNGTGSNKDERFKAMQYLQNLKAERGAATSKTLEEEHIDKSHEFYTSLTGEDEDLPEDQTDSAAVKTLLRVSDAAGHFKSTVVKTGHIAASDLDSKDVFILDNGSTCFVWVGNGASAQEKRNGLGYAHSHLMKTPHPLIPILRHQRGQASKCFNAALAA
What is the function of this protein?
Calcium-regulated protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping).  Can promote the assembly of monomers into filaments (nucleation) as well as sever existing filaments.
What are the official names of this protein?
Gelsolin-like protein 2, Actin-modulator, EWAM-P2.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: SODF_BURSP
Sequence: MEHTLPPLPFDKNALAPHMSEETLEYHYGKHHQTYVTNLNKLIPGTEFENLSLEEIVKKSSGGVFNNSAQVWNHTFFWNSLSPKGGGAPTGALADAINAKYGSFDKFKEEFAKVATGTFGSGWTWLVKKTDGTVDIVSTSNAATPLTTDAKALLTIDVWEHAYYIDYRNARPKFIEAYWNIANWDFAAKNFGA
What is the function of this protein?
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).  Involved in the metabolism of 4-aminophenol.  May have an indirect role in hydroxyquinol metabolism by scavenging and detoxifying reactive species that promote its auto-oxidation (PubMed:20480210).
What are the official names of this protein?
Superoxide dismutase [Fe], SOD-like protein.
What is the protein family that this protein belongs to?
Belongs to the iron/manganese superoxide dismutase family.
Protein: OPSD_SOLSO
Sequence: MNGTEGPYFYIPMLNTTGIVRSPYEYPQYYLVNPAAYAALCAYMFLLILLGFPINFLTLYVTIEHKKLRTPLNYILLNLAVANLFMVFGGFTTTMYTSMHGYFVLGRLGCNLEGFFATLGGEIGLWSLVVLAVERWMVVCKPISNFRFTENHAIMGLGFTWFAASACAVPPLVGWSRYIPEGMQCSCGVDYYTRAEGFNNESFVVYMFVCHFLIPLIVVFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVVIMVIAFLICWCPYAGVAWYIFSNQGSEFGPLFMTIPAFFAKSSSIYNPLIYIFMNKQFRHCMITTLCCGKNPFEEEEGSTTTSKTEASSASSSSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.