PharMolix/UniProtQA huggingface dataset:
Protein: VPYL_MEDTR
Sequence: MDRLVKTEFNEVNLNFQKNQKCSSSFKLTNLMHTMSVAVSLTTTNPTTFSINKPLSVIPPLSSSTYTLHLTNLNQPPLSEPADVITVRTSMLPTGKATTDDLRRLFNKPGPHVFRDAVITVILVGPTVAEYVISNYETRNLFTKAISVCTKSNLTNLMKPAVESGKVEYVTDLITAGGDVNFRDSNGKSLIPFAIRTGKLAVLKLLVANGCRINDSVDFVLHEAAIIDRVDVVKFLFESFCDELDVNSVNREMMTPIHVSASEGHVSLIEFFVSIGGNANAVDSRRWTPLHHAASRNHLKAVEFLLENSDVKYARELNGKTAFEIASESGHTRLFGVLRWGDALLQAARVDDVHALKKCLGEGAEVNRKDQNGWTPLHWASFKGRIKSVKVLLEHGAEVDSVDDAGYTPLHCAAEAGHLQVALVLIAHGGCQTNLKSFQHVSPIATFQKHVSLHYSTKKSETFA
What is the function of this protein?
May be involved in arbuscular mycorrhizal (AM) symbiosis with AM fungi and in nitrogen-fixing rhizobial bacteria symbiosis leading to the formation of root nodules.
What are the official names of this protein?
Protein VAPYRIN-LIKE, MtVpyl.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PDI21_ARATH
Sequence: MAKSQIWFGFALLALLLVSAVADDVVVLTDDSFEKEVGKDKGALVEFYAPWCGHCKKLAPEYEKLGASFKKAKSVLIAKVDCDEQKSVCTKYGVSGYPTIQWFPKGSLEPQKYEGPRNAEALAEYVNKEGGTNVKLAAVPQNVVVLTPDNFDEIVLDQNKDVLVEFYAPWCGHCKSLAPTYEKVATVFKQEEGVVIANLDADAHKALGEKYGVSGFPTLKFFPKDNKAGHDYDGGRDLDDFVSFINEKSGTSRDSKGQLTSKAGIVESLDALVKELVAASEDEKKAVLSRIEEEASTLKGSTTRYGKLYLKLAKSYIEKGSDYASKETERLGRVLGKSISPVKADELTLKRNILTTFVASS
What is the function of this protein?
Protein disulfide isomerase that may be required for proper pollen development, ovule fertilization and embryo development.
What are the official names of this protein?
Protein disulfide-isomerase like 2-1, AtPDIL2-1, P5, Protein MATERNAL EFFECT EMBRYO ARREST 30, Protein UNFERTILIZED EMBRYO SAC 5, Protein disulfide isomerase 11, AtPDI11, Protein disulfide-isomerase A6, Protein disulfide-isomerase like 4-1, AtPDIL4-1.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum.
Protein: TFB2M_DROME
Sequence: MLPLRCSWSFARANYSTKKELVTRYSGDFPEKLLNRKQKVPTHMYIANSEAAARINQYLEPHFQSSGCDTVMELNSGAGYFTRHLLDRESQFRRIILLESMDHFMPKIQELHTLYPERVKVRQGDFVNLWKLVYMDKMDGGSRVADLLSDVPQKAFTDDINMLVFGAVGSYPFFKHLINSLIFQTSLFNLGRCEMILAMPPPIYIHLTCNNEIGYLIYRSTSVLFQILFEHKFIAKVPREDFLPQQMAYSPTKSSKLGKVQSINPEYLYLVKFTPRRNLHELCQSQDLPALWFFIKQNYVSRRNRIIPNLEKWVPGCGPRLIINPKSSESVTPIYPDELPKKLPQYSCQSTTMSTRNYYPGINIYTQFGDLLPSQILTLFSQFRQWPEYGESSFLASLENALLKLETANDEPNLEDGVTLPEEDDAEADEIIEEESPVPATTPVKRRRKASS
What is the function of this protein?
Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop.  Also required for basal transcription of mitochondrial DNA.  Also regulates mitochondrial DNA copy number.  Stimulates transcription independently of the methyltransferase activity.
What are the official names of this protein?
Dimethyladenosine transferase 2, mitochondrial, Mitochondrial 12S rRNA dimethylase 2, Mitochondrial transcription factor B2, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2, d-mtTFB2.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: TGT_LACP7
Sequence: MYKLICKDGNAKRGEFTTVHGKIQTPVFMNVGTAAAIKGAVSTMDLQEIGTQVELSNTYHLHVRPGDEVVKKLGGLHKFMVWDKPILTDSGGFQVFSLAGLRKIKEEGVYFNSHIDGKKIFMGPEESMRIQSNLASTIAMAFDECPPHPATREYMEDSVARTTRWLLRCKNEMNRLNTLEDTINKHQMLFGINQGGTYTDIRVEHAKRISELDLDGYALGGLAVGESHSEMYRIIEETVPYLPEAKPTYLMGVGTPANILEAVERGVDFFDCVYPARNGRHGHAYTNHGKMNLLNAKYELDDRPIEEGCGCPVCKNYSRGYIRHLLKAKEMLGLRFLVTHNLYFYNKMMEEIREAIENQNFASYKKKKLEGFAAEQGN
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: PIGE_SERSF
Sequence: MKFGFIAHPTSLGLKRYVKMLDLLQRNSTEQHSGYTRELWERQNLVPFMNFARITSATGATCEGVIKYMPLVADEMLADARGIAARVVQGIEELAGDGAELVGLGGFTSIVGRRGEATAEKSPVPVTSGNSLTTYAGYKALMQIQSWLEIRPEEEPVAIVGYPGSICLALSRLLLAHGFSLHLLHRAGNHDRSELLSHLPEEYHSRVTLTSDPEDLYPRCKLFAAATSAGGVIDPARLQPGSIFIDVALPRDIASETRPARDDILIIDGGCVTATDAVKLGGESLNVTIKQQLNGCMAETIVLALENRRENFSLGRYLAPEKVLEIGEIAERHGFFAYPLASYGERIDRQSVTNLKRYYHHDIYAGESADAALPASRLAFIDAVIAQTPAREDTLDRYHQYINPMMVDFLKLQRCDNVFRSAAGTQLYDDAGEAFLDMVAGYGCLNLGHNPQPVVNALKNYLDAQGPNFIQYISIPEQTAKLAEVLCRLAPGNMGRVFFSNSGTEAVEAAMKIAKASTGKPGIAYLRNSYHGKTLGALSITGRDKHRRYFTPLLDAMVEVPFGDLAALREALNREDVGALMIEPIQGEGGVHIPPAGYLQAVQQLCRETGVLLMVDEVQTGLGRTGKLFACEWDGIEPDVLMLSKSLSGGLIPIGATLCRADLWQKAYGTADRFLVHSSTYGGGNLASVVALSALREILAQDLVGHAERMGAYFKQALSEIAARYPFVSEVRGRGLMLGIQFDQAFTGAVNASAREFATRLPGDWHTTWKFLPDPVQAHLRAAMDRMEQALGEMFCMKFVTKLCQDHKILTFITANSSTVIRIQPPLIISKAEIDRFVGAFATVCEELSTFLD
What is the function of this protein?
Involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig).  Catalyzes the transamination to the aldehyde group of 3-acetyloctanal, resulting in an aminoketone, which spontaneously cyclizes to yield the dihydro form of MAP (H2MAP).
What are the official names of this protein?
Aminotransferase PigE.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
Protein: SYL_PARMW
Sequence: MNSRYSPADLEQRWQTTWRSEGLDVTPEPEDGKGFYALSMFPYPSGTLHMGHVRNYVITDVIARVQRMRGHSVLHPMGWDAFGLPAENAAIERNVDPGDWTDRNIDQMRSQLDRLGLSIDWDREQATCHSDYYRWTQWLFLELFDGGLAYRKNATVNWDPVDQTVLANEQVDADGRSWRSGALVEQRQLNQWFLRITQYAEALLNDLDQLSGWPERVRTMQANWIGRSEGAEIQFKVSSDSDTTITVFTTRPDTLAGASCVVLAPDHPLVNSLTSPDQQDVVQAFQAEVARLSALERTSDDAPKRGVFTGATVLNPLNGRALPVWIADYVLVDYGTGAVMGVPAHDQRDRRFAQSYGLAVQQVIEAEGAAAAIAAGEAWTDPGVLIHSGDFDGLNSIEAKERITRHGEQQGWAVAKVTYRLRDWLISRQRYWGCPIPIIHCPSCGAVPVPREDLPVVLPRGIDLSGKGGSPLEQQQDWVNVPCPSCGEPAKRETDTMDTFMCSSWYFLRFADPHNTEQPFSREAVNRWLPVQQYVGGIEHAILHLLYSRFFTKALKDRGLIDVAEPFDRLLTQGMVQGTTYRNPSTGKYVASADVSDPETPTDPTSGEPLEVLFEKMSKSKYNGVDPAAVIDRYGADTARMFILFKAPPEKDLEWDDSDVEGQFRFLQRIWRLVESADSRIDSLEPEERPEPLADTDAKVRRAIHIAIDAVSEDLQDEIQLNTAISELMKLTNAITSVGVAELSTSVLKEALSTLLRLLAPFAPHLAEELWHQLGGTSSVHRAGWPELDPSALVQDSVDLVIQIKGKVRGTIQVPAAADKEQLEALALASEIAAKWLEGHPPRRVIVVPGKLVNLVP
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: U1125_ARATH
Sequence: MESGDYDVETKREKLKSVLSQLLADPILADVPRNPTLSDVVTLVSLEKGSAMRLSVVKLDGSSLDVAVMNSATLKDLKLLIKKKVNEMEQANMGHRHISWKHVWSNFCLSCNNEKLLDDNAVLQDVGIRNNSQVTFMPYVMKKGRGRHSKRKKHRLFRSLHKTSS
What are the official names of this protein?
U11/U12 small nuclear ribonucleoprotein 25 kDa protein, U11/U12 snRNP 25 kDa protein, U11/U12-25K.
What are the subcellular locations of this protein?
Nucleus.
Protein: CAPSD_BYDVN
Sequence: MSTVVLRSNGNGSRRRRQRVARRRPAARTQPVVVVASNGPARRGRRRRPVGPRRGRTPRSGGGSRGETFVFSKDSLAGNSSGSITFGPSLSEYPAFQNGVLKAYHEYKITNCVLQFVSEASSTAAGSISYELDPHCKASSLASTINKFTITKTGARSFPAKMINGLEWHPSDEDQFRILYKGNGASSVAGSFKITLRVQLQNPK
What is the function of this protein?
Major capsid protein.
What are the official names of this protein?
Major capsid protein, Coat protein, CP.
What is the protein family that this protein belongs to?
Belongs to the luteoviruses capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: Y3405_BRUSU
Sequence: MSRQPILDIKGLRTVFRTRAREIVTVNDVDIVVNPGETVALVGESGSGKSVTSLSIMRLLARKVGFIDAGSIILRGKSGQTVDLAAIDEEAMRRIRGNDIGMVFQEPMTSLNPVYTIGDQIGEPLRVHRGTSRREALEAAVELLDRVGIPDARRRAGQYPHELSGGMRQRATIAMALICNPTLLIADEPTTALDVTIQAQILDLMQKLQSESGMGMLFVTHNLGVVAEIAQRVVVMYAGRIVESGPVKEVFRNPRHPYTMGLLRSMPRLGDATEMKRRGEKLNTIPGMVPGLANLPSGCAFAPRCSFAVEACHAAVPPLASVNEHHGSRCIRWQEIAA
What is the function of this protein?
Probably part of an ABC transporter complex that could be involved in peptide import.  Probably responsible for energy coupling to the transport system (By similarity).
What are the official names of this protein?
Putative peptide import ATP-binding protein BRA0405/BS1330_II0402.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATIF1_MOUSE
Sequence: MAGSALAVRARFGVWGMKVLQTRGFVSDSSDSMDTGAGSIREAGGAFGKREKAEEDRYFREKTKEQLAALRKHHEDEIDHHSKEIERLQKQIERHKKKIQQLKNNH
What is the function of this protein?
Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix.  Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity).  Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme (PubMed:23135403).
What are the official names of this protein?
ATPase inhibitor, mitochondrial, ATP synthase F1 subunit epsilon, Inhibitor of F(1)F(o)-ATPase, IF(1), IF1.
What is the protein family that this protein belongs to?
Belongs to the ATPase inhibitor family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PLY1_PECCA
Sequence: MKYLLPSAAAGLLLLAAQPTMAANTGGYATTDGGDVSGAVKKTARSLQEIVDIIEAAKKDSSGKAVKGGAYPLVITYNGNEDALIKAAEANICGQWSKDPRGVEIKEFTKGITILGTNGSSANFGIWMVNSSNVVVRNMRFGYMPGGAKDGDAIRIDNSPNVWIDHNEIFAKNFECAGTPDNDTTFESAVDIKKGATNVTVSYNYIHGVKKVGLSGSSNTDTGRDLTYHHNIYSDVNSRLPLQRGGKVHAYNNLYDGIKSSGFNVRQKGIALIESNWFENALNPVTARNDDSNFGTWELRNNNITSPSDFAKYKITWGKPSTPHINADDWKSTGKFPAVPYSYSPVSAQCVKDKLASYAGVGKNLAVLTAANCK
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.
What are the official names of this protein?
Pectate lyase 1, Pectate lyase A, PLA, Pectate lyase I, PEL I.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 1 family. PLADES subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RL27B_YEAST
Sequence: MAKFLKAGKVAVVVRGRYAGKKVVIVKPHDEGSKSHPFGHALVAGIERYPSKVTKKHGAKKVAKRTKIKPFIKVVNYNHLLPTRYTLDVEAFKSVVSTETFEQPSQREEAKKVVKKAFEERHQAGKNQWFFSKLRF
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
What are the official names of this protein?
60S ribosomal protein L27-B, Large ribosomal subunit protein eL27-B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL27 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOT3_ARATH
Sequence: MEKWMNLRDEDLTEETKTLISSLSSEKGYLGRNLCKYQGSWYYYNFLQGVLNFQRGFKPQDTDIIVASYPKSGTLWLKALTVALFERTKNPSHDDPMSHPLLSNNPHNLLSSSSPRLFSTHTPFHTLQVAVKDSPCKVVYICRDAKDSLVSRWHIVCRSLNKEEDRTILESMFESFCSGVCLFGPFWDHILSYWKASLEKPKQVLFMRYDEIKTDPHGQLKKLAEFLGCPFSKEEEKNGSLNKILEMCSLPNLSSLEVNKTGKSINGIEYKNHFRKGIVGDWKNHLTPEMGSKIDMIMKEKLKDYSEVWFENAL
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor.
What are the official names of this protein?
Cytosolic sulfotransferase 3, AtSOT3.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_PARXL
Sequence: MLKNPATKYRSFKPIDLTDRQWPSRTITRPPIWMSTDLRDGNQSLFEPMDAQRKMRMFKTLVQIGFKEIEVAFPSASQTDFNFVRELIEGGHIPDDVTIEVLTQARDDLIERTFESLRGVPRAIVHLYNATAPEFRKIVFNLEKSGVKELAQNAARTMKRIAATMPETQFTFQYSPEVFSGTEIEFAKEVCDAVFDIWEPTPEHKAIVNLPATVEMSTPNIYADQIEWMHRNLKRRDSLVISVHPHNDRGTAVAAAELAVMAGADRIEGCLFGNGERTGNVDLVTLALNLYTQGVDPGLDFSNINEVARTAEECTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQKPDAMWEVPYMPIDPADLGRTYDSVIRVNSQSGKGGIAYLLEQGYGVVLPRRLQVDFSSAVQRFTDDSGQEVTSAQIWELFQQEYVQNATPVHYVGHSLSERDGREHIKLTVDINGTRRVLNGAGNGPLDALMHAIGVPVRIQHYEERALTQGADARAVAVAEMAGADVTGSAFGVGIDANLVTASIRAVISGVNRAYARVNAQAKERFFEAAMNDATESVGV
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: GLYA_SHEB2
Sequence: MLKKDMNIADYDPELFNAIQNETLRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVVETLAIERAKELFGATYANVQPHSGSQANSAVYMALLKPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIIPYGIDESGKIDYDEMERLAVEHKPKMMIGGFSAYSGIVDWAKMREIADKIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTSTTHKTLAGPRGGVILSAADDEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKVYQQQVVNNAKAMVEVFLERGYKIVSGGTSNHLMLVDLIGRDLTGKEADAALGSANITVNKNSVPNDPRSPFVTSGVRIGTPAITRRGFKEAESKELTGWICDILDDASNPAVIERVKGQVLALCARFPVYG
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPDF_AGRVS
Sequence: MVHIQADGARSTAVILVAAGRGERAGASSEGPKQYRRIGGKPVIVHSLLGFADLLPQATLIVVIHPDDGALLANALAPYPQLAASLTITHGGKTRQQSVLAGLRALRNQKPDYVLIHDAVRPFFDQLMLQRIIARLDDGADAVLPAIPVTDTLKRGDEGARVVDTVARSGLFAAQTPQSFHFAKILAAHEDAASAGREDFTDDAAIAEWAGLTVHLVEGSPDNVKLTVKRDLEMADARLSHNALPDVRTGNGYDVHQLVPGDGVTLCGIFIAHDQALSGHSDADVALHALTDALLATCGAGDIGDHFPPSDPQWRGAASRIFLEHAANIVRDAGGTIMNADISLIAEAPKIGPHRQIMREKLSEILGIALERCSVKATTNEKIGFVGRGEGIAAIATATVVFQGKPQ
What is the function of this protein?
Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
What are the official names of this protein?
Bifunctional enzyme IspD/IspF.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the IspF family.
Protein: FBXW8_RAT
Sequence: MEDHNLEEFRQRWQEELAHSQVLRRRRRLEAGERRPRRPEAGARGEPASGYLGLAQGLLEGAGRPPAPRPGRTDRKDVSSRSRSPPDRDAAEPEPLVDQLIRDLNEMDDVPFFDVHLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCRQEGHLPHSRFSDYTCWKLILQECLAPVHLIRPSWMNRKGAVSELEHVPDAVLCDVRSHDGVVIAGYTSGEVRVWDTRTWDYVAPFLESESEEEDPGMQPYVSFVRINSSLAVAAYEDGILNVWDLRTGRFPIFRFEHDARIQALALSQEKPVVATASAFDVVMLYPNEEGNWHVASEFEVQKLVDYLEIVPNTGRYPVAIATAGDLVYLLKAEDSARTLHYVYGQPATCLDVSASQVAFGVKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNIRDSPPNLMVSGNMDRRVRLHDLRTDKIALSLSAHQLGVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVHSRHPVRYISFNSHSLITANVPYEKVLRNSDLDNFACHRRHRGLIHAYEFAVDQLAFQSPLPICRLPRDTVAGYSYDLALSFPYDSI
What is the function of this protein?
Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation.  Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity).  The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain.
What are the official names of this protein?
F-box/WD repeat-containing protein 8, F-box and WD-40 domain-containing protein 8.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons.
Protein: DTD_KLEP3
Sequence: MIALIQRVSRASVTVEDEVTGEIGPGLLVLLGVEKDDDEQKANRLCERVLGYRIFSDAEGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSKGAAPDRAEALYEYFVARCRQQEMNTQTGRFAADMQVSLVNDGPVTFWLQV
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLIS2_DROME
Sequence: MDIIQKSIFNSGPHSRGIYEPPLGYFTPYNTPPYIAAYSDSGSWLADHHQHHQQQHQQHQQQMQHIRFPTPPITPPRPIAGYGYRQRTQSVIMKARGQQDELCRSPVEFPDDSKSCSSSSECGTASDFVCNWTDCDRVFDTLDALAQHVTQRHAIASLTDGLYYCRWRGCQRSERGFNARYKMLVHTRTHTKEKPHRCHLCEKSFSRAENLKIHIRSHSGEKPYKCSFEGCQKAYSNSSDRFKHTRTHSMEKPYMCKVAGCQKRYTDPSSLRKHVKTFKHSIHLIASQPLTLPSVPCLLEASSESAFTCLPAASSVESTSSSSSARYYDDSNNEPSDYSLKPKQDAEFSPSYWLGDRQHSYLHSEDFFVKMDVESPLDLRIHRI
What is the function of this protein?
Transcription factor which represses a set of lipase genes involved in fat catabolism.
What are the official names of this protein?
Zinc finger protein GLIS2 homolog, Protein sugarbabe.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y3976_BACC0
Sequence: MEYQYPLDYDWSNEEMVTMVKFYEAIEKAYEKGIIREELMGLYRRFKEIVPSKAEEKKIDKEFQEVSGYSIYRAIQRAKEIEEQKLVKM
What are the official names of this protein?
UPF0223 protein BCAH820_3976.
What is the protein family that this protein belongs to?
Belongs to the UPF0223 family.
Protein: MIAB_PARL1
Sequence: MPEAGPEAEPGSPRKKIFVKTYGCQMNVYDSARMVDVMAPSGYTEVDAPEDADIVILNTCHIREKAAEKVYSELGRLRELKKEKSGRGEELLIGVAGCVAQAEGEEMRRRAPVVDLVLGPQTYHRLPEYVARLANGGPGIVETEFPVDDKFASLPMAEKRKTLARGATAFLTIQEGCDKFCTFCVVPYTRGSEFSRPVARILDEARSLVDAGVREITLLGQNVNAWHGEDQAGRPATLGYLIRALAEIEGLARLRYTTSHPRDMDEELIAAHRDVPALMPYLHLPVQSGSDRILAAMNRRHDADSYHRIIGRIRAAKPDIALSSDFIVGFPGETEADFEATLDLIRTVGFAQAYSFKYSPRPGTPAATEEDQVPEEVKSERLQRLQALLGEQQLAFNAGCAGRTMPVLFDRRGRGESQLVGRSPYLQSVHIDDAPEHLFGSLVDVVIEEGHRNSLRGRLREEAAVLA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SIA10_PANTR
Sequence: MRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQPCLSKPAFASLLRFHQFHPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTMILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNLVINLTQD
What is the function of this protein?
Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant.  Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids.  Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity).
What are the official names of this protein?
Type 2 lactosamine alpha-2,3-sialyltransferase, CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI, ST3Gal VI, ST3GalVI, Sialyltransferase 10.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 29 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: TPIS_BORAP
Sequence: MRKTFLAGNWKMHYTSAEASIVAKQIATEVKTLNDDFVIMITPPFTALSKVSECIKGSNILLGAQNMSYMESGARTSEISPSMLLEFGVEYVILGHSECRLYLAETDEIINKKIRAGLKHSFKYLILCVGETLDERDSGKTLDVVLSQVKKGLDCVSESDIKRIILAYEPVWAIGTGKTATKEEAEEVHKAIRLEIMKLYSKSASDNIIIQYGGSVNASNIKELMNEPNIDGALIGGASLKAESFLSIINNVR
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_RALSO
Sequence: MTASVAAAPDPAGLDPELAHIAPALKAEILAQALPYIRKFHGKTIVIKYGGNAMTEEKLKHGFARDVILLKLVGMNPVVVHGGGPQIDDALKKVGKTGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVMLINQYGGQAVGLTGKDGGLIRAKKLKMPDREQPGQFIDIGFVGDIETINPAVVRALQDDAFIPVISPIGFSDDGQAYNINADVVAGKMAEILKAEKLVMMTNIPGVMDKQGNLLTDLSAREIDELFADGTISGGMLPKISSALDAAKSGVNSVHIIDGRIEHSLLLEILTEQAFGTMIRSH
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF40_PORPU
Sequence: MINKNISIQINGEPFNCSEPLSLQFLLNYLDFNSERIAIEINSTLLPERLFHSTYINDQDKVEIITIVGGG
What are the official names of this protein?
Uncharacterized protein ycf40.
What is the protein family that this protein belongs to?
Belongs to the ycf40 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.