PharMolix/UniProtQA huggingface dataset:
Protein: RL21_BEUC1
Sequence: MVYAIVKAGGRQEKVSVGDIVVVDRVGGEVGDTIELTPILLVDGDKVTNGKDLADVRVSAEIVRPEKGPKITILKFKNKTGYRKRQGHRQKLTRLKVTDIA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: CLIC4_BOVIN
Sequence: MALSMPLNGLKEEDKEPIIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNNEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK
What is the function of this protein?
Can insert into membranes and form chloride ion channels.
What are the official names of this protein?
Chloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass membrane protein. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
Protein: TYSY_MYCBT
Sequence: MSIVTPYEDLLRFVLETGTPKSDRTGTGTRSLFGQQMRYDLSAGFPLLTTKKVHFKSVAYELLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPAPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERMALPPCHAFFQFYVADGRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGLSVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLLLADRDSIFEYTYEDIVVKNYDPHPAIKAPVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STX10_LYCMC
Sequence: MKFCVAVSLLIIASMAGVISVSGYDVYPRDYAENYYYCGVRKDPDCSKICKLHGARVGYCHVKRCSCVDLPEKNQNFLSVIWKHC
What are the official names of this protein?
Neurtoxin 10.
What is the protein family that this protein belongs to?
Belongs to the long (3 C-C) scorpion toxin superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PCKA_NOVAD
Sequence: MSDTTLNVSLASQGYPEPAELFANLGTAPLVEHAVRNGEGLLCVDGPLVVETGKHTGRSAKDKFIVRDAETENTVWWGKTNVAMSPEHFAALKADFIKALGEKDRLYVADLFGGSQPEHRVKVRVINELAWHNLFIRTLLVRPTTDELASFVPEYTIIDLPSFRADPARHGSRSETVIAVNFTEKLILIGGTAYAGEMKKSVFGILNYLLPVKGVMPMHCSANVGPDGKTAVFFGLSGTGKTTLSADASRTLIGDDEHGWSDTAVFNFEGGCYAKMIRLSAEAEPEIFATTKRFGTVLENVVIDPVTRTIDLDDNSLAENSRGSYPIDFIPNASEENLGPVPANLIFLTADAYGVLPPIARLTPDQAMYHFLSGYTARVAGTEIGVTEPEATFSTCFGAPFMPRHPSVYGNLLKERIAKGGVKCWLVNTGWSGGKATQEGIKRMPIKATRALLNAALDGSLNSATFTKDPNFGFEVPVEVPGVDTKLLDPRGAWADGEEYDKTAQELVRKFVDNFQQFADHVDQSVRDAAPVAA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARNF_PECAS
Sequence: MTNKGYFWVVASLVLASAAQVLMKSGMLALPSISMTHWPSLSTLMAGWPVVAVLVGIICYGLSMVCWFMVLRYLPLSRAYPLISLSYAVVYLAAVFLPWLNEPMSLRKNLGVLIILLGVWLVSRDAQATK
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SMG_THIDA
Sequence: MLDILVYLYESFRMAELAPDRDALEKRLFAAGFEEAHINATLDWFANLTSSAAHDRLAYAQYRHYAPEELESLNDACREEISYLVGAEILDPESREWVISGLMALAGEDIEPDHVRWMTLIVLWSRGLIEHFTHLEEMLLNHEPGRLH
What are the official names of this protein?
Protein Smg homolog.
What is the protein family that this protein belongs to?
Belongs to the Smg family.
Protein: RS5_HALH5
Sequence: MRRIDPNTLELEEKVVAINRVAKVVKGGRRFRFAALVVVGDKNGRVGFGMGKAQEVPEAIRKAVEDAKKNLIEVPIVGTTIPHEIVGRFGAGRVLLKPASEGTGVIAGGPVRAVLDLAGVGDILSKSLGSNNPINMVRATVKGLQELKRAEDVAKLRGKTVEELLG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: DAPB_STAAT
Sequence: MKILLIGYGAMNQRVARLAEEKGHEIVGVIENTPKATTPYQQYQHIADVKGADVAIDFSNPNLLFPLLDEDFHLPLVVATTGEKEKLLNKLDELSQNMPVFFSANMSYGVHALTKILAAAVPLLDDFDIELTEAHHNKKVDAPSGTLEKLYDVIVSLKENVTPVYDRHELNEKRQPQDIGIHSIRGGTIVGEHEVLFAGTDETIQITHRAQSKDIFANGAIQAAERLVNKPNGFYTFDNL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STR2_SCHPO
Sequence: MTENYGSMEHRKKSFRNNENLEQQFHPLREELDNAGPINDRTSELSLEGVSKAEAIASTWSKRSIIVAYLGLYLLSFASSLEQQTTYSLQRYATSNFSAHSNLATINLVGNILLAVVRAPMVKAADVFGRSESLSLALGMTVLGYLSLAFSRNIQMFTVAYILYICGQTGLGLLSQLIIADTSSLLNRGILSAIPELPYLATVWIGPVLAQAFHPEKNYGWRLGYGIWAFILPTVSLPLLASLFLNQRKAKAAGLYREHHNLINHSTPEKLRLFYLFWQELDGLGIVLFVSGFTLLLLPFSHSSQVVSPDSTILTLFTITLSIALLVTLCFYDVKYARYPVFALKSLKDRTILGSCVLIFTYFMSYYIFSNFLTSFLQVSYGLSIDMSSLTLNVFVFSMTTTAILSGFLMKRFGRFKMLLMISVPMYVLGILGIILFGINDNHYTRPLVLVLILAGMGGGLLTLSAQIAVQSVSSHAKLGMNLTLYLTFSSVGGAFGSAIAGGVWSKRLSSRLLHDLKDHLPVPEIESIFRDLRTALSYPQGTQIRNIINVAYTATEKDLFHISLVASLFMFAGLVIIRDVPLSTENHDTAVETPSE
What is the function of this protein?
Involved in the transport of siderophore iron and so has a role in iron homeostasis.
What are the official names of this protein?
Siderophore iron transporter 2.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ERB1_YEAST
Sequence: MMAKNNKTTEAKMSKKRAASEESDVEEDEDKLLSVDGLIDAEASESDEDDDEYESAVEEKESSSDKEAQDDSDDDSDAELNKLLAEEEGDGEEDYDSSEFSDDTTSLTDRLSGVKLQTIVDPNIYSKYADGSDRIIKPEINPVYDSDDSDAETQNTIGNIPLSAYDEMPHIGYDINGKRIMRPAKGSALDQLLDSIELPEGWTGLLDKNSGSSLNLTKEELELISKIQRNEQTDDSINPYEPLIDWFTRHEEVMPLTAVPEPKRRFVPSKNEAKRVMKIVRAIREGRIIPPKKLKEMKEKEKIENYQYDLWGDSTETNDHVMHLRAPKLPPPTNEESYNPPEEYLLSPEEKEAWENTEYSERERNFIPQKYSALRKVPGYGESIRERFERSLDLYLAPRVRKNKLNIDPNSLIPELPSPKDLRPFPIRCSTIYAGHKGKVRTLSIDPSGLWLATGSDDGTVRVWEILTGREVYRTTLIDDEENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTKIEDGFGYDTFGTVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKLSWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQRYVRIYDLSQQILVKKLLPGARWLSKIDIHPRGDNLIASSFDKRVLWHDLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDGTIHVFHATVYDDMMKNPMIVPLKKLTGHKVINSLGVLDAIWHPREAWLFSAGADNTARLWTT
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein ERB1, Eukaryotic ribosome biogenesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: LMBL1_HUMAN
Sequence: MHLVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVHSLLCSLPTHLLAKLSFASDSQY
What is the function of this protein?
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications.  PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription.  Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes.  Also recognizes and binds RB1/RB monomethylated at 'Lys-860'.  Participates in the ETV6-mediated repression.  Probably plays a role in cell proliferation.  Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
What are the official names of this protein?
Lethal(3)malignant brain tumor-like protein 1, H-l(3)mbt, H-l(3)mbt protein, L(3)mbt-like, L(3)mbt protein homolog, L3MBTL1.
What are the subcellular locations of this protein?
Nucleus. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
Protein: MURG_CHLFF
Sequence: MKKINKIALAVGGSGGHIVPALATRETFCKEGIDVLLLGKGLDNYPNLCEQDIPYREIPSGSLSISRPIAAIRNTRSLYIGYKKAKKELIAFGPDVVIGFGSYHSLPVLMAALKKKIPIFLHEQNLVPGKVNKLFSRFAKGVGVSFSPVTKQFSCPAQEVFLPKRVWASSNSSKELSSSYSPIICVVGGSQGAKTLNDNVPPALVKVAKDYPNMYVHHIAGPKGEVASIQYVYSRGGVSFCVKHFEHDMLNILLSSDLVISRAGATILDELLWAQTPSILIPYPGAYGHQEENAKFLVYTIGGGSMILEKQLSNEVLTKNILLALDSKTIKNRREALRAYYQNKSSKSFYQFICECL
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y4776_PARPJ
Sequence: MKTFLLYAVTAVAEVVGCYLPWRWLKEGGSIWLLVPGALSLALFAWLLTLHGTAAGRVYAAYGGVYVAVAIAWLWCVDKVRPTLWDAAGVAFTLAGMAIIAFQPRV
What are the official names of this protein?
UPF0060 membrane protein Bphyt_4776.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IF2_WIGBR
Sequence: MKNVTIKSFSEEIKIPINKLIQKFADAGITKTNIDYVSLEEKKILLSYINSHHVNLPKNLSLQKKTKSKLNISSLNGKNKIVKIEVRKKKYLKCDSSLLFKDKIVKNNIDKTFCKKNIKDLNKTKKYVELSKNINEREINFEKKLIKEPILDKSKLKISKNLIKKNVKINKNLNIYKKNEFKQNLKKNKLNKKEKNKKIEINYKVKNKNENIFKKIKSNRLFGSETNFFNNNIDKKTNIRKKISSLTHTFNKPLKKIIKEITIGETISVFELSNKMAVKSHKVVSNMMKLGIKSSINEVIDQDIAQIIAEEMGHKVKLIKNNALEEEIIKNQNKNLYELKNRAPVVTIMGHVDHGKTSLLDYIRTTKVALKEKGGITQCIGAYYVKTKKGIITFIDTPGHAAFTEMRIRGSKITDIIVIVIAADDSIMPQTVEAINHAKIAKVPVIIAINKIDKITSNPEKVKKELIKHGIFLEEYGGDTQCLLISAKSGLGIDFLLDAILLQAEILELKAMHKGMASGTVIESRLEKGKGPVSTILIQEGRLHQGDVVLCGCEYGKIKAMQDSFKCKIKSVGPSIPVEILGLSGIPISGDKITVVKEEKKAREVAIYRQNKLRESKLRINKKIKIENVFSNLNLSTKKNINIVLKSDAHGSSQAISNALILLSNEEIKINIIYSGVGPITETDVALATSSNAIIIGFNVKPDFSNIKNTESIGLNIKCCSIIYEIVDFVKQKIYLSCNTKYNKKIIGILIVKNIFQLPKLGSIAGCIVKEGIVKKNSIAKILRNKSFVHESKIISLRRFKEDVNEVKSGTECGIVIKNFNDIKPLDIIEILELEELNKKI
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_KORVE
Sequence: MSNSQVIEKLLAKAKRTDLPSFAPGDTVRVHVKIKEGDKERLQAFEGVVIGKSNGLQPSFTVRKISFGQGVERIFPTNSKVIDKIEVLRSAKVRRAKLYYLRALRGKAARLKEAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: MURD_CERS5
Sequence: MIPVRGLEGRKVAVLGLGRSGLATARALQAGGAEPLLWDDSPEARANAEGQGFAVTDLTRERAFEDVALLVTSPGIPHLYPAPNPVIARAMAAGVPVDNDIGLFFRSFATRDWDAFDQMPRVVCVTGSNGKSTTTALIHHILAESGRPTQMAGNIGRGVLDLDPARDGEVVVLELSSYQTDLARALTPDVAVFTNLSPDHLDRHGGMGGYFAAKRRLFAEGGPDRAVIGVDEPEGLYLAGQLSVAPEDDRVIRISAGQKLERFGWAVFARKGFLAEWRKGRQMASIDLRAMPGLPGAHNHQNACAAYAACRTLGLAPRQIEEALGSFKGLPHRSQLVGERNGVRFVNDSKATNVDSAAKALQAFPKIRWIAGGLGKDGGIAALRPHLDAVVKAYLIGHSARDFALQMGATDHEICETMDRAVVRAAEEAQPGEVVLLAPAAASFDQYPNFEKRGEDFMERVKALL
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSH5_ARATH
Sequence: MEEMEDTETEPQVYMACIQHGRRVGVSYYDCSVRQLHVLEFWEEDCSDFTLINMVKYQAKPSIIYASTKSEESFVAALQQNDGTDETTMVKLVKSSTFSYEQAWHRLVYLRVTGMDDGLNIKERICYLSSMMDVGSEVQVRVSGGLLAILESERIVETLEQNESGSASIAIDSVMEVPLNKFLKLDAAAHEALQIFQTDKHPSHMGIGRAKEGFSVFGMMNKCATPMGRRLLRSWFMRPILDLEVLDRRLNAISFFISSVELMASLRETLKSVKDISHLLKKFNSPTSLCTSNDWTAFLKSISALLHVNKIFEVGVSESLREHMRRFNLDIIEKAGLCISTELDYVYELVIGVIDVTRSKERGYQTLVKEGFCAELDELRQIYEELPEFLQEVSAMELEHFPHLHKEKLPPCIVYIQQIGYLMCIFGEKLDETALNRLTEFEFAFSDMDGETQRFFYHTSKTRELDNLLGDIYHKILDMERAIIRDLLSHTLLFSAHLLKAVNFVAELDCILSLACVAHQNNYVRPVLTVESLLDIRNGRHVLQEMAVDTFIPNDTEINDNGRIHIITGPNYSGKSIYVKQVALIVFLSHIGSFVPADAATVGLTDRIFCAMGSKFMTAEQSTFMIDLHQVGMMLRQATSRSLCLLDEFGKGTLTEDGIGLLGGTISHFATCAEPPRVVVCTHLTELLNESCLPVSEKIKFYTMSVLRPDTESANMEEIVFLYRLIPGQTLLSYGLHCALLAGVPEEVVKRAAIVLDAFESNNNVDKLSLDKISSQDQAFKDAVDKFAELDISKGDIHAFFQDIFTS
What is the function of this protein?
Involved in meiotic recombination in association with MSH4.  Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis.  Promotes homologous recombination through facilitating chiasma formation during prophase I.  Involved in the control of class I crossovers formation.
What are the official names of this protein?
DNA mismatch repair protein MSH5, AtMSH5, MutS protein homolog 5.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=In pollen mother cells during meiosis, localizes to unsynapsed axes during leptotene and zygotene, but is not present on synapsed regions of zygotene nuclei.
Protein: RAP2_MAGO7
Sequence: MYIPSARTAIVQDDKGGLKIDRNAPMPQPRPNELLVQVKAVAINPCDHKMYERFPTPGAVDGCDFAGIVVQLGSDVKTFQIGDRVCGAVHGSNPSRPESGTFAEYTVSDGEFTLKLPPNLSFREAMGLGTTGLSTIGMAIYKGLMLPGSPLEPAEKPRTVLVHGASSSVGTMALQLIRLMGHIPIATCSPRNFELVKKYGAEEVFDYNDPECGQQIKQYTGNTLAYIIDPFTDVKSVALCYEAMGRAGGRYACLEMYPEFALERRSIKVFFALGMALLGHSLDLAYGYERDEDPEMRSFGIGWYKVLQELLYQGKLRPHPLRELEGGFEGILKGVQMVKNKEVSGQKLVVSLE
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of a tyrosine-derived cytochalasan acting as a fungal signal recognized by resistant rice plants and leads to avirulence in Pi33 resistant rice cultivars (PubMed:18433432).  The first step in the pathway is catalyzed by the hybrid PKS-NRPS ACE1, assisted by the enoyl reductase RAP1, that are responsible for fusion of the tyrosine precursor and the polyketide backbone (PubMed:29142718).  The polyketide synthase module (PKS) of ACE1 is responsible for the synthesis of the polyketide backbone and the downstream nonribosomal peptide synthetase (NRPS) amidates the carboxyl end of the polyketide with the tyrosine precursor (PubMed:29142718).  Because ACE1 lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase RAP1 (PubMed:29142718).  Reduction by the hydrolyase ORFZ, followed by dehydration and intra-molecular Diels-Alder cyclization by the Diels-Alderase ORF3 then yield the required isoindolone-fused macrocycle (Probable).  A number of oxidative steps catalyzed by the tailoring enzymes identified within the cluster, including cytochrome P450 monooxygenases CYP1 to CYP4, the FAD-linked oxidoreductase OXR2 and the short-chain dehydrogenase/reductase OXR1, are further required to afford the final cytochalasans that confer avirulence and which have still to be identified (Probable).  The monooxygenase CYP1 has been shown to be a site-selective C-18 hydroxylase whereas the function of CYP3 is the site-selective epoxidation of the C-6/C-7 olefin that is present in some intermediate compounds (PubMed:31644300).  Finally, SYN2 and RAP2 are not required for avirulence in Pi33 resistant rice cultivars (PubMed:18433432).
What are the official names of this protein?
Trans-enoyl reductase RAP2, ACE1 cytochalasan biosynthesis cluster protein RAP2.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: H5_COTJA
Sequence: TESLVLSPAPAKPKRA
What is the function of this protein?
Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells.
What are the official names of this protein?
Histone H5.
What is the protein family that this protein belongs to?
Belongs to the histone H1/H5 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: PSTB2_STRA5
Sequence: MAEYNWDERHIITFPEENSALTTKDLHVYYGEKEAIKGIDMQFEKNKITALIGPSGCGKSTYLRSLNRMNDTIDIARVTGQIMYEGIDVNAQDINVYEMRKHIGMVFQRPNPFAKSIYKNITFAYERAGVKDKKFLDEVVETSLKQAALWDQVKDDLHKSAFTLSGGQQQRLCIARAIAVKPEILLMDEPASALDPIATMQLEETMFELKKNYTIIIVTHNMQQAARASDYTAFFYLGDLIEYDKTNNIFQNAKCQSTSDYVSGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 2, ABC phosphate transporter 2, Phosphate-transporting ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: UE74_DORVU
Sequence: MLKFILALALFLHLTMEASAACKGKKCPPTGFVGMRG
What is the function of this protein?
Probable toxin.  Does not show insecticidal, antimicrobial and antiparasitic activities.  Does not induce increase in intracellular calcium in mouse DRG neurons, suggesting that it does not induce pain.
What are the official names of this protein?
U-limacoditoxin(14)-Dv74, U-LCTX(14)-Dv74, Vulnericin.
What is the protein family that this protein belongs to?
Belongs to the limacoditoxin-13 family.
What are the subcellular locations of this protein?
Secreted.
Protein: FOLD_CHLSY
Sequence: MSARILDGKALAQELRAEAAAQIAELRTQIDRPPTIAVVQVGDDPAATRYVRSIDRLCQSLGAACRAIALPAETAQADLEATVATLSADDRIDGILLQLPLPAGLTLDGVLSRLAPEKDLDGIHPINAGLLAQGRPTLTPNTPAGGIELMRRYGIDIRGRRAAVVGRSAIVGRPMALLLLQADATVTICHSRTPDLGAVLRECDIIAAAAGRPGLITADMVKPGATVIDFGTNVLADGSMVGDVDFAAVAEVAGAITPVPGGTGPVTNIMLMRNLITATRTRLGI
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL22_SYNJB
Sequence: MADSSPEVKAVARYIRMSPFKVRRVLDQIRGRTYADALILLEFMPYAACEPVRKVLRSAVANAEHNNGLDPRDLVISQAYADQGPVLKRFRPRAQGRAYPIRKRTCHITIAVRPIEEAEAATAS
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RAMQ_EUBLI
Sequence: MRVLFPLLEEEIDVSQESLVSDVCASIGLPLNLVCGGKGRCKKCLVNVKENGEMKEVLACQYSVSDGMEIYASREQAASQILETSSNSDLPFDPIVKCYSLNYTDLVTPMCTYDLDVLRKLIPQTIDTPDYSVLKHFSEVYFLEGYERLHVIVSGNRIIDFIPSNEKEKPIYGIAFDIGTTSVVGYLYDITSGCLLNQHSMLNKQIAFGGDVISRIDYAGEGPESLHKIYEAIMETLAEIITQVCKKASIDTKDIYQTVYCGNSTMAHLFLELNPKHLGLAPFLGFCKDAISLKGMDTPLPINPKGTVTFMPLLGGFVGADTTAVLLGLPRDKKMRLMIDLGTNGEIAVGNCDKYYVASTACGPALEGAGLTMGMRGTTGAIEKVGCENGKITYSVIGKTAPQGFCGSGIVDAIAMLFREGLIAKRGNFIKGDALDAHPMKNRFGVDENNQRYFKIVTAGENPEGKDIIITQKDVRAVQLAKAAIYTGCCLLSENYGIKGSDLEEIVIAGAFGNYIDVHNAQFIGLLPKIEGVPVRSIGNGAGTGAQLYLLSKEEAGICNAIPRITTHIELATDPKFVETYMMNTMFGDNVMI
What is the function of this protein?
Involved in the degradation of the quaternary amines L-proline betaine and L-carnitine (PubMed:31341018, PubMed:32571881).  Component of a corrinoid-dependent methyltransferase system that transfers a methyl group from L-proline betaine or L-carnitine to tetrahydrofolate (THF), forming methyl-THF, a key intermediate in the Wood-Ljungdahl acetogenesis pathway (PubMed:31341018, PubMed:32571881).  RamQ is not required for the methyl transfer, but it stimulates reduction of reconstituted MtqC from the Co(II) state to the Co(I) state in vitro (PubMed:31341018).  It also stimulates the rate of THF methylation (PubMed:32571881).
What are the official names of this protein?
Corrinoid activation enzyme RamQ.
Protein: C3H43_ARATH
Sequence: MVNSEEIADGFEPKPVSRSYSGDSSHDRSLSDLNHAAEDLSDKLKNVGLNEVTKEQSEKMMSVSESNGGLDSNAVVTINQEEEEEEEDRDGYGYGDGWSENESENVYPVRPGAEDCSFYMRTGSCKFGSSCKFNHPLARKFQIARDNKVREKEDDGGKLGLIDCKYYFRTGGCKYGETCRFNHTIPKSGLASAPELNFLGLPLRPGEVECPYYMRNGSCKYGAECKFNHPDPTTIGGTDSPSFRGNNGVSIGTFSPKATFQASSTSWSSPRHVNGTSPFIPVMLSQTHGVTSQNPEWNGYQASVYSSERGVFSPSTTYLMNNSSAETSMLLSQYRHQMPAEEFPERPDQPECSYYMKTGDCKFKFNCKYHHPKNRLPKLPPYALNDKGLPLRPDQNICTYYSRYGICKFGPACRFDHSVQPPYSTESSQAIVEPPQVSANGNESDGWN
What are the official names of this protein?
Zinc finger CCCH domain-containing protein 43, AtC3H43, Zinc finger CCCH domain-containing protein ZFN-like 6.
What are the subcellular locations of this protein?
Nucleus.