PharMolix/UniProtQA huggingface dataset:
Protein: PNP_MYCSS
Sequence: MSVVEIEDGVYESTAVIDNGSFGTRTIRFETGRLAQQAAGAVVAYLDDETMLLSATSASKSPKDHFDFFPLTIDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPTFVSGLRNEIQVVVTVMSLDPKDLYDVVAINAASASTQIAGLPFSGPVGGVRVALIDGTWVAFPTVEQLERAVFDMVVAGRKTADDVAIMMVEAEATDKVVELVAGGAQAPTEAVVAEGLEAAKPFIKVLCEAQQELAGRAAKPTADYPLFPEYGEDVYYAVASVATDALSEALTIAGKEERNNRTDEIKVEVLGRLADQFAGREKEIGGAFRSLTKKLVRQRILTDHFRIDGRGVTDIRALSAEVAIVPRAHGSALFERGETQILGVTTLDMVKMAQQIDSLGPETSKRYMHHYNFPPYSTGETGRVGSPKRREIGHGALAERALMPVLPSVEEFPYAIRQVSEALSSNGSTSMGSVCASTLSLLNAGVPLKAPVAGIAMGLVSDDVEVDGKTERRFVTLTDILGAEDAFGDMDFKCAGTKDFVTALQLDTKLDGIPSQVLAGALAQAKDARITILEVMAEAIDAPDEMSPYAPRITTIKVPVDKIGEVIGPKGKMINSITEETGASISIEDDGTVFVGASNGEAAQAAIDKINAIANPQLPKIGERFLGTVVKTTDFGAFVSLLPGRDGLVHISKLGRGKRIAKVEDVAKVGDKLRVEIADIDNRGKISLVLVAEEEAAEASDNGSATPSDKAPATADATTAGN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHAS_ESCF3
Sequence: MTKLHSVDFFPAQEVSVAIEPRLPQGAFPEHHHDFHEIVIVEHGTGIHVLNGQPYTISGGMVCFIRDSDRHMYEHTDNLNLTNVLYRSPDKFRFLAGLHQLLPQECNGHYPSHWRIDQHTLQQVRQLITRLEQVSAGQDLSTVANREILFMQLLVALRKNSLLEGDENTDARLNHLIAWLEDHFAEAVSWEAIADRFALSLRTLHRQLKQHTGLTPQRYLNRLRLVKARHLLRHSDDSVTHIAFSCGFADSNHFSTLFRREFGWSPREIRQGRDASLQ
What is the function of this protein?
Activates expression of the rhaBAD and rhaT operons.
What are the official names of this protein?
HTH-type transcriptional activator RhaS, L-rhamnose operon regulatory protein RhaS.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BUD28_YEAST
Sequence: MNLFFVFFFVFFWSDLVEGQSVFVGLGRDKSDPVSQLVLLQVLLCQVLQVLTRELGSGNNSNNGTIFSDSDSVTQVTDSTFDLDVVDQVLSVGSWVEDTVFSWRRDIDGKGLGNLLLSGSLYQKN
What are the official names of this protein?
Putative uncharacterized protein BUD28.
Protein: Y4660_METAC
Sequence: MMKIIAFVGMPASGKSEASRIAAEMDIPVIIMGDVIRKEVLKRGLEPNDSNTGMVATDLRKCEGMDAVARRCVSQIRETGSELVVVDGVRGIAEVECFRQEFGKGFILISIYAPLEVRFSRVQKRGRSDDMNSIDGLRQRDERELSWGMGEAIEASNVEIENSFTLETFRKDVNDVLNNYLKSNSEK
What are the official names of this protein?
UPF0200 protein MA_4660.
What is the protein family that this protein belongs to?
Belongs to the UPF0200 family.
Protein: DNAJ_PARP8
Sequence: MAKRDYYQVLGVAKNASDDEIKKAYRKLAMKHHPDRNPGNKDAEEHFKEAKEAYEMLSDSQKRAAYDQYGHAGVDPNMAGAGAQGFGGFADAFGDIFGDIFGQAAAGGRGGRSGPQVYRGADLRYSMEITLEQAAHGYDTQIRVPSWVSCEICHGSGAKPGTKPETCPTCNGSGAVRMSQGFFSIQQTCPKCHGTGTYIPEPCTHCHGAGKTKETKTLEVKIPAGIDDGMRIRSAGNGEPGINGGPSGDLYVEIHIKAHAVFERDGDDLHCQMPIPFTKAALGGEIEVPTLAGRATFTVPEGTQSGKTFRLRGKGIKGLRSSIAGDLYVHVQVETPVKLTDAQRDLLQQFEKSLVEGGARHSPQSKSWFDRVKSFFD
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPB5_ASFP4
Sequence: MAMQKLFTYIYEFIKYRKMVLLEEKVPYDKFVQMVLNTGFFRINAETLNHGIVSVFIFGANGKYVHHGGDMRTLLTNTLNEKKHYEELILIVDKPVLSKKNILDIIVEQRAANPTIVINIYPYHLFCINIPKVSAIPRHKLITQEEAQEFLGREYLQPQDLMQISASDPPVVWLGGRPGDFVQIERPSETAMHAVVIRFITKSKI
What is the function of this protein?
Component of the DNA-directed RNA polymerase (RNAP) that catalyzes the transcription in the cytoplasm of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase RPB5 homolog, RPB5 homolog.
What is the protein family that this protein belongs to?
Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Host cytoplasm. Virion. Note=Found in association with viral nucleoid.
Protein: RNC_RHIL3
Sequence: MSKAQTLSAADRAKLEGLIGHDFAEKERLDRALTHASARTEKGGNYERLEFLGDRVLGLCIAELLFRTFGTAGEGELSVRLNQLVSAETCAAVADELNLHLYIRTGADVKKLTGKRMMNVRADVVESLIAAIYLDGGLEVARRFILRYWQGRAVRADGAKRDAKTELQEWSHAKFGVTPIYRVDERSGPDHDPRFKVTVEVAGIKPETGVERSKRAAEQVAATKMLEREGIWQQSPAGN
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y306_STRT2
Sequence: MKNNSIRTVVATGIGAALFIIICIFVNIPIFGNTSIQLQYAVQVLFSVIFGSRSIIGFFMGFIGQVLKDGIQYGDISWAWVLASGITGLVIGLFGKKYDVTMGKFSVMSMIWFNLAQALGLLIAYGVVTPIGDKIQFAQAWSYLYAQSFVAGVANFITIAIGGTLLLAIYASSRTQSGSLTKG
What are the official names of this protein?
UPF0397 protein stu0306/stu0307.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PLCZ1_PIG
Sequence: MENKWFLSMVRDDFKGGKINLEKAQKLLEKLDIQCNTIHVKCIFKDNDRLKQGRITIEEFRTIYRIIAHREEIIEIFNAYPENRKILFERNLIDFLTQEQYSLDINRSIVYEIIQKYEPIEEVKQAHQMSFEGFTRDMGSSECLLFNNECGSVYQDMTHPLSDYFISSSHNTYLISDQIMGPSNLWGYVSALVKGCRCLEIDCWDGSQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFITSDYPVVLSLENHCSLSQQEVMADNLQSVFGDALLSDVLDDCPDRLPSPEALKFKILVRNKKIGTLKETHERKGFDKHGQVQECEEEEEAEQEEEENEVRDSEILDILQDDLEKEELKRGVGIKFFKKKKVKIATALSDLVIYTKVEKFRSFHYSRLYQQFNETNSIGETQARKLSKLRASEFILHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLENGNSGYILKPHFLRDGKSIFNPNKAPINSNPITLTIRLISGIQLPPSYHSSSNKADTLVIIEIFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIQVPELALIRFVVENQGLITGNEFLGQYTLPVLCMNKGYRRVPLFSKMGESLEPASLFIYVWYIR
What is the function of this protein?
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.  In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner.  Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage.  Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.  May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
What are the official names of this protein?
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1, Phosphoinositide phospholipase C-zeta-1, Phospholipase C-zeta-1, PLC-zeta-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity).
Protein: EGLN1_HUMAN
Sequence: MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
What is the function of this protein?
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins.  Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A.  Also hydroxylates HIF2A.  Has a preference for the CODD site for both HIF1A and HIF1B.  Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.  Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes.  EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality.  Target proteins are preferentially recognized via a LXXLAP motif.
What are the official names of this protein?
Egl nine homolog 1, Hypoxia-inducible factor prolyl hydroxylase 2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Mainly cytoplasmic. Shuttles between the nucleus and cytoplasm (PubMed:19631610). Nuclear export requires functional XPO1.
Protein: RPOA_BRADU
Sequence: MGETVTIQKNWQELIRPNKLQVTPGSDPARFATIVAEPLERGFGQTLGNALRRILLSSLQGAAVQSVHIDGVLHEFSSIAGVREDVTDIVLNIKDISIKMQGEGPKRMVVKKQGPGVVTAGDIQTVGDVVVLNPDLQICTLDEGAEIRMEFTVATGKGYVPAERNRPEDAPIGLIPVDSLYSPVRKVSYKVENTREGQILDYDKLTMTIETNGAISPDDSVAYAARILQDQLNVFVNFEEPRKEVAQEIIPDLAFNPAFLKKVDELELSVRSANCLKNDNIVYIGDLVQKSEAEMLRTPNFGRKSLNEIKEVLAQMGLHLGMEVPGWPPENIDELAKRFEDHY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: TRM82_CRYNB
Sequence: MALHCPPTALATSSTSLFIAAGPALHVFNPSTSTFASCPADGTGGLIRLLAVREDGEVAATLGEDKQLAVWDIQHDRPQLRHTRTVVKKGSCLSFAKDGSIILTDKVGDVYSYPLDPVPIDPSAERPPMYTLVADPSQNPDATYLLGHVSMLNAHVMTPDGRRIITADRDEHIRVSRYPKAYVIDKYLFGHDGFVSALHIPPSNPSLLLSAGGDPSLLIWNPSTGKLLTSVPVWPAVLSHRRVRSHLRRHKPGSRKLKMDPVPEDMDEENQTFYTAPEGYMLPSGQGVCIKKIESVKIGGETVVLFFSEGASAIHSFILPTDPEGVKPTVHTLPLPHPLIDFTPIPSTSSADEKEVLLSLDTAWDVLKKNPGPGIEGRQDTIQRDDLSDEEKRNISKIFSVARISADGHLSLGDASVYDSLVSNLPSTDIKTLSNVNLYPLLCVLPRWPGFEEGDEELTVNTGTPDTPGTPGPADAVSLAPTSGAFLQKSYTQEELEKMNTKQLGRLKSAGIDVGSILLARQKKAKEEHKARKAAAKAKAEAQKNQKEGGRPAKKKKKVEMSEEELANA
What is the function of this protein?
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.  In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82, Transfer RNA methyltransferase 82.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ANMK_BACHK
Sequence: MYIVGVMSGTSLDGIDVALVRIEGSGVESKVELIHFTTVPFCNDIKSEIQQALSIENSNVQLICSLNFKLGLCFANAVKEVCKEANFSLEQLDLIGSHGQTIYHQPKQDGNRIPSTLQIGEPAVIAYETNTTVISNFRTMDMAAGGQGAPLVPYSEVILYRDPSKNRLLQNIGGISNVTVIPSQQSDQNVIAFDTGPGNMIIDEVCQRLFQLPYDQNGEIAKQGRVVDEILTYCMSHPFLKMNPPKSTGREQFGEKFVSELLKRFEKHSKENILTTVTMFTVNSIVHHYKKFILPYYEIDEVILGGGGSYNSTLVEMLRNGLKDENCAIFIQEDIGYSSEAKEAIAFAILANETHHRNPSNVPSATGAKQSVVLGNITFPPL
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: YQGT_BACSU
Sequence: MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCPGYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPFVSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLCCNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFNEWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPPDRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIHHYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE
What are the official names of this protein?
Uncharacterized protein YqgT.
What is the protein family that this protein belongs to?
Belongs to the peptidase M14 family.
Protein: Y1096_STRS7
Sequence: MSQDIYDYANKLERAVRALPEYRKALEAREEIKADEAASQLFDEFVAVQEKLQGLMQTGQLPTETEQADIQALSQKIEANDLLKGYFNAQQALSIYVNDIERIVFAPLKDLAK
What are the official names of this protein?
UPF0342 protein SZO_10960.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: ESXA_STAAC
Sequence: MAMIKMSPEEIRAKSQSYGQGSDQIRQILSDLTRAQGEIAANWEGQAFSRFEEQFQQLSPKVEKFAQLLEEIKQQLNSTADAVQEQDQQLSNNFGLQ
What is the function of this protein?
Virulence factor that is important for the establishment of infection in the host.  EsxA is required for EsxB synthesis as well as secretion (By similarity).  Modulates host cell apoptotic pathways and mediates together with EsxB the release of S. aureus from the host cell.  By acting on apoptosis, plays a role in the modulation of dendritic cell-mediated immunity (By similarity).
What are the official names of this protein?
Type VII secretion system extracellular protein A, Ess extracellular protein A.
What is the protein family that this protein belongs to?
Belongs to the WXG100 family. sagEsxA-like subfamily.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the ESAT-6 secretion system (Ess) / type VII secretion system (T7SS).
Protein: TRPF_ZYGBA
Sequence: MIAKICGLQSVEAAQQAVDNGADLIGVICVPNRKRTVDPEIARSISKICHGTGTRLVGVFRNQPKEEVRQLAQEYELDVVQLHGDEDWQEYASYVGLPLLKRVVFPRDVSLVSQMDGEVCTPLFDSEAGGSGEKLDWQAIGSWFQDSQLTRGYLLAGGLSPDNVVEALRVPGVVGVDVSGGVETDGTKDLAKIKQFLELYKVNVN
What are the official names of this protein?
N-(5'-phosphoribosyl)anthranilate isomerase, PRAI.
What is the protein family that this protein belongs to?
Belongs to the TrpF family.
Protein: TYSY_STRT2
Sequence: MTKADTIFKENITKIMEEGVWSEQARPKYKDGTTANSKYITGSFAEYDLSKGEFPITTLRPIAIKSAIKEVFWIYQDQTNSLDVLEDKYNVHYWNDWEVEGVPANNGDKRSIGQRYGAVVKKHDIINRLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLDGTLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLKRQPSDCQPRLVLNVPDETNFFDIKPEDFELVDYDPVKPQLKFDLAI
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS4B_MYXXD
Sequence: MARDLGPRGKMCRRLGIPLSRITAKDPDKDPVLRRPYPPGQHGATARTSVSDFARRLREKQKLKLYYGLMEKQCRAVFQEASRAPGNTGTVLLQLLESRLDSLVLRAGLATSIRQARQFVRHGYLHVDGKRADIPSFRVKPGSEVRFHAAHQKLAVVQESFSRMKSRSVPAYVQVLGEGEGLRYVRLPEREEIPVDVNEPFIVEYYAQRS
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4 B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: VE1_HPV39
Sequence: MANREGTDGDGSGCNGWFLVQAIVDKQTGDTVSEDEDENATDTGSDLADFIDDSTDICVQAERETAQVLLHMQEAQRDAQAVRALKRKYTDSSGDTRPYGKKVGRNTRGTLQEISLNVSSTQATQTVYSVPDSGYGNMEVETAEVEEVTVATNTNGDAEGEHGGSVREECSSVDSAIDSENQDPKSPTAQIKLLLQSNNKKAAMLTQFKETYGLSFTDLVRTFKSDKTTCTDWVAAIFGVHPTIAEGFKTLINKYALYTHIQSLDTKQGVLILMLIRYTCGKNRVTVGKGLSTLLHVPESCMLLEPPKLRSPVAALYWYRTGISNISVVTGDTPEWIQRLTVIQHGIDDSVFDLSDMVQWAFDNEYTDESDIAFNYAMLADCNSNAAAFLKSNCQAKYVKDCATMCKHYKRAQKRQMSMSQWIKFRCSKCDEGGDWRPIVQFLRYQGIEFISFLCALKEFLKGTPKKNCIVIYGPANTGKSHFCMSLMHFLQGTVISYVNSTSHFWLEPLADAKLAMLDDATGTCWSYFDNYMRNALDGYAISLDRKYKSLLQMKCPPLLITSNTNPVEDDRWPYLRSRLTVFKFPNAFPFDQNRNPVYTINDKNWKCFFEKTWCRLDLQQDEDEGDNDENTFTTFKCVTGQNTRIL
What is the function of this protein?
ATP-dependent DNA helicase required for initiation of viral DNA replication.  It forms a complex with the viral E2 protein.  The E1-E2 complex binds to the replication origin which contains binding sites for both proteins.  During the initial step, a dimer of E1 interacts with a dimer of protein E2 leading to a complex that binds the viral origin of replication with high specificity.  Then, a second dimer of E1 displaces the E2 dimer in an ATP-dependent manner to form the E1 tetramer.  Following this, two E1 monomers are added to each half of the site, which results in the formation of two E1 trimers on the viral ori.  Subsequently, two hexamers will be created.  The double hexamer acts as a bi-directional helicase machinery and unwinds the viral DNA and then recruits the host DNA polymerase to start replication.
What are the official names of this protein?
Replication protein E1, ATP-dependent helicase E1.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E1 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: NDHH_PROM2
Sequence: MAQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGENVIDCEPVIGYLHRGMEKIAENRTNVMYVPYVSRMDYAAGMFYEAIVVNAPERLANIPVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNFFRIGGVACDLPYGWLEKCIDFCDWFGPKIDEYEKLITNNPIFRKRIEGLGTIQRDQAINWSLSGPMLRASGVSWDLRKVDSYECYDDFDWQIASEKEGDCYARYRVRVEEMRQSLSIIRQACKMIPGGPTENLEAQRMATEDKKSEIFGIDYQYVAKKVAPTFKIPNGELYTRLESGKGEIGVFIQGNNEVTPWRFKIRAADLNNLQILPHILKGAKIADIMAILGSIDVIMGSVDR
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit H, NAD(P)H dehydrogenase subunit H, NADH-plastoquinone oxidoreductase subunit H, NDH-1 subunit H, NDH-H.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: TATA_BRUSU
Sequence: MGSFSIWHWLIVLAVVLLLFGRGKIPELMGDVAKGIKNFKQGMADEDAKEDPRTIDAKAEEPVKDVKKTTKS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: IOLA_BACP2
Sequence: MTKTDVQMLKNYIGGQWIEAETSQTEAVYNPATGKIIAEVPLSTKKDVERAVQAAQEAFTTWSKTPVPRRARILFKYQQLLVDKWDELAELVTMENGKSITEAKGEVQRGIECVEFAAGAPTLMMGKQLPDIASGLESGMYRYPIGVIGGITPFNFPMMVPCWMFPLAIACGNTFVLKPSERTPILAARLAELFEEAGLPKGVLNIVNGAHDVVNGLLEHQKVKAISFVGSQPVAEYVYKKGTEHGKRVQALAGAKNHSIVLKDADLDAATKQIIGAAFGSAGERCMAAAVVAVEEEVADDLIQKLVDESNELVIGNGINEEVFLGPVIREEHKERTLQYIQSGIEEGASLIRDGRKDHETNGKGYFVGPTIFDHVTNQMKIWQDEIFAPVLSIVRVSSLAEAIDLSNQSKFANGACLYTDSASSIREFRENIEAGMLGVNIGVPAPMAFFPFSGWKDSFYGDLHANGTDGVEFYTRKKMVTARYM
What is the function of this protein?
Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.
What are the official names of this protein?
Malonate-semialdehyde dehydrogenase, MSA dehydrogenase, Methylmalonate-semialdehyde dehydrogenase, MMSA dehydrogenase, MSDH.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. IolA subfamily.
Protein: EMTA_ENT38
Sequence: MKLRWFAFLMVLLAGCSSKKDYQNPPWNPEVPVKRAMQWMPISEKAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYMGWKGQPSTSELKNPERNISMGTAYLSILEHGVLKGIDDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINGMDKNEFVDHVAKNHPAPQAPRYIWKVQKAMDAM
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.  Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
What are the official names of this protein?
Endo-type membrane-bound lytic murein transglycosylase A, Peptidoglycan lytic endotransglycosylase.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TIM8_KLULA
Sequence: MSSISQNDLSNLDDGSKKEIMTFLESENSKQKVQMSIHQFTNLCFKNCISNVQNADLSSQEEQCLNNCVNRFLDTNIRIVKGLQSIQ
What is the function of this protein?
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane.  Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane.  Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.  The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit TIM8.
What is the protein family that this protein belongs to?
Belongs to the small Tim family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Protein: RL9_YERPE
Sequence: MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNVEFFEARRAELEAKLADVLAAAEARATKINELVSVTISSKAGDEGKLFGSIGTRDIADAVTAAGVEVAKSEVRLPNGVLRTAGEHEVHFQVHSDVFAKLNVVVVPEA
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.