PharMolix/UniProtQA huggingface dataset:
Protein: ALGL_AZOCH
Sequence: MKTRLALPCLLGSLLLSSAVHAASALVPPKGYYAALEIRKGEAQACQAVPEPYTGELVFRSKYEGSDSARSTLNKKAEKAFRAKTKPITEIERGVSRMVMRYMEKGRLRRAGMRPGLLDAWAEDDALLSTEYNHTGKSMRKWALGSLAGAYLRLKFSTSQPLAAYPEQAKRIEAWFAKVGDQVIKDWSDLPLKQINNHSYWAAWSVMAAGVATNRRPLFDWAVEQFHIAAKQVDPRGFLANELKRRQRALAYHNYSLPPLMMIAAFAQANGVDLRGDNDGALGRLAGNVLAGVEDPEPFAERAGEDQDMEDLETDAKFSWLEPYCALYACSPALRERKAEMGPFKNFRLGGDVTRIFDPQEKPSKSTVGNAD
What is the function of this protein?
Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism.  Degrades deacetylated polymannuronate alginate more efficiently than non-deacetylated polyM.  Is able to degrade its own alginate, but at a lower efficiency than that produced from M. pyriferia and P. aeruginosa (PubMed:10049370).  May serve to degrade mislocalized alginate that is trapped in the periplasmic space (By similarity).
What are the official names of this protein?
Alginate lyase, Poly(beta-D-mannuronate) lyase.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide lyase 5 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DNAK_AERS4
Sequence: MGKIIGIDLGTTNSCVAILDGDTARVIENAEGDRTTPSIIAYADDGEILVGQPAKRQAITNPKNTLFAIKRLIGRRFEDEEVQRDLKIMPYAIAKADNGDAWVEVKGKKMAPPQISAEVLKKMKKTAEDYLGEPVTEAVITVPAYFNDAQRQATKDAGRIAGLDVKRIINEPTAAAFAYGVNKVKGERKVAVYDLGGGTFDISIIEIDEVEGETTFEVLATNGNTHLGGEDFDNRVINYLVDEFKREQGIDLRNDQLALQRLKDAAEKAKIELSSAQQTDVNLPYITADATGPKHMNIKVTRAKLESLVEDMVKDSLEPVRTALKDSGLAVGEIDDVILVGGQTRMPMVQKTVAEFFGKEPRKDVNPDEAVAMGAAIQGAVLSGEKTDVLLLDVTPLSLGIETMGSVMTALIEKNTTIPTKKSQVFSTAEDNQSAVTIHVLQGERKRASDNKSLGQFNLEGIRPAQRGLPQIEVTFDIDANGILHVSAKDKETNKEQKITIQASSGLSDEEIERMVREAEANAAEDKKFEELVQTRNQADGLVHSVRKQITEAGDALPADDKTKIETALSELEAVIKGDDKAVIEAKQQALLEASQKLMEIAQQQSQAQGAGADANQSSSSSKADDDVVDAEFEEVKDDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: HEMT2_GOLVU
Sequence: MGFPIPDPYVWDPSFRIFYSIIDDEHKTLFNGIFHLGHDDSADNLAELRRCTGKHFLNEQVLMQDSQYAGYAEHVRAHDGFIHQLDNWHGDVKWAKNWLVNHIKTIDFKYKGKI
What is the function of this protein?
Hemerythrin is a respiratory protein in blood cells of certain marine worms.  The oxygen-binding site in each chain contains two iron atoms (By similarity).
What are the official names of this protein?
Hemerythrin subunit 2, Hr 2.
What is the protein family that this protein belongs to?
Belongs to the hemerythrin family.
Protein: RIMM_SHEPC
Sequence: MSSNQQPVVLGKLGSCHGIKGWLRITAYTDSVEGIFDYSPWLIKENGEWREVKVTQWRYQGKAVVAELEGVNTREQAQMLTNCEIAILPEQMDALPEDEFYWRDLIGCEVVNTTGYNMGIVDQIVETGSNDVLLVKANAKDSFGKVERMIPFVPEQFIKTVDVQGKQILVDWDPDF
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ANS1A_MOUSE
Sequence: MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGSGSGGGSGGGGLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHRDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIQQGPSHTRVNEQNALEIRELKKYGPFDPYINAKNNDNETALHCAAQYGHTEVVKALLEELTDPTMRNNKFETPLDLAALYGRLEVVKLLLGAHPNLLSCSTRKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGIDVNIKDNRGLTALDTVRDLPSQKSQQIAALIEDHMTGKRSVKEVDRTSTAQLPLLSNTDAIAPMSQGSMEKTVTELILHFDTHADEEGPYEALYNAVSCHSLDSTASGRSSDRDSMNKEAEATGTRAAGVRPRERPPPPAKPPPDEEEEERVDKKYFPLAASEGLAVRPRIQSSAPQEEEEHPYELLLTAETKKLGTTDGRTEDHRQSGSGRSQDSVEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLTAPSQSHPESSQQDACHEASMQLEEPGVQGTEPPQPGVPDQSKRVGLPAGLTALASRTYLDALTHTVPLRPAGAEEEDQSGPRSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFASEWDEIEKIMSSIGEGIDFSQEQQKISGSRTLEQSVGEWLESIGLQQYESKLLLNGFDDVRFLGSNVMEEQDLREIGISDPQHRRKLLQAARSLPKVKALGYDGVSPTSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVHLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLISQTSSPLSQNDSCTGRSADLLLPSADTSRRRHDSLPDPGTASRADRFRVQEEPSETKLTLRPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHMKKIPTIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQKSRTMAASAASMIETKSSKPVPKPRVGMRKSALEPPDSDQEAPSHASVSWIVDPKPDSKRSLSTN
What is the function of this protein?
Regulator of different signaling pathways.  Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction.
What are the official names of this protein?
Ankyrin repeat and SAM domain-containing protein 1A, Odin.
What are the subcellular locations of this protein?
Cytoplasm. Cell projection. Note=Cytoplasmic before and after growth factor treatment.
Protein: EFP_TOLAT
Sequence: MKIAQEIRVGNVIMIGKDPMVVLKTEFNKSGRNSAVVKMKMKNLLSGAGAETVFKADDKLDTVQLERKECTYSYFADPMYVFMDTEYNQYDIEKENLGDVLNYLIDGMEDICEVTFYDGKAISMELPITIVREVEYTEPSVRGDTSGKVMKPAKLKGTDATISVADFVKIGDKIEIDTRTGEFKRRV
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CUCS_SIRGR
Sequence: MWRLKVGAESVGENDEKWLKSISNHLGRQVWEFCPDAGTQQQLLQVHKARKAFHDDRFHRKQSSDLFITIQYGKEVENGGKTAGVKLKEGEEVRKEAVESSLERALSFYSSIQTSDGNWASDLGGPMFLLPGLVIALYVTGVLNSVLSKHHRQEMCRYVYNHQNEDGGWGLHIEGPSTMFGSALNYVALRLLGEDANAGAMPKARAWILDHGGATGITSWGKLWLSVLGVYEWSGNNPLPPEFWLFPYFLPFHPGRMWCHCRMVYLPMSYLYGKRFVGPITPIVLSLRKELYAVPYHEIDWNKSRNTCAKEDLYYPHPKMQDILWGSLHHVYEPLFTRWPAKRLREKALQTAMQHIHYEDENTRYICLGPVNKVLNLLCCWVEDPYSDAFKLHLQRVHDYLWVAEDGMKMQGYNGSQLWDTAFSIQAIVSTKLVDNYGPTLRKAHDFVKSSQIQQDCPGDPNVWYRHIHKGAWPFSTRDHGWLISDCTAEGLKAALMLSKLPSETVGESLERNRLCDAVNVLLSLQNDNGGFASYELTRSYPWLELINPAETFGDIVIDYPYVECTSATMEALTLFKKLHPGHRTKEIDTAIVRAANFLENMQRTDGSWYGCWGVCFTYAGWFGIKGLVAAGRTYNNCLAIRKACDFLLSKELPGGGWGESYLSCQNKVYTNLEGNRPHLVNTAWVLMALIEAGQAERDPTPLHRAARLLINSQLENGDFPQQEIMGVFNKNCMITYAAYRNIFPIWALGEYCHRVLTE
What is the function of this protein?
Oxidosqualene cyclase involved in the biosynthesis of the highly oxygenated tetracyclic triterpenes mogrosides and cucurbitacins (PubMed:29192442, PubMed:25759326).  Converts oxidosqualene to cucurbitadienol (PubMed:29192442, PubMed:25759326).
What are the official names of this protein?
Cucurbitadienol synthase, SgCbQ.
What is the protein family that this protein belongs to?
Belongs to the terpene cyclase/mutase family.
Protein: CYNS_RICCO
Sequence: MAETKATLTNRLLAVKHNSGKSYSEIAEETGLTNVYVAQLFRRQAQLKPDTALKLRAVLPELSDELLGEMMRPPMRSYDPNLIQEPSVYRLNEAVMHFGESIKEIINEEFGDGIMSAIDFYCSVDKVKGVDGKDRVVVTFDGKYLPYSEQKTEHMVSRLRQNGN
What is the function of this protein?
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
What are the official names of this protein?
Cyanate hydratase, Cyanase, Cyanate hydrolase, Cyanate lyase.
What is the protein family that this protein belongs to?
Belongs to the cyanase family.
Protein: CSOS2_PROMP
Sequence: MSTKTSREIALERRKAMSDGGKKAALHSSSTKDRVRSSQDINSTGATSSNKKVLTSPSKSNIPANKIARKSTSSKLSSKELGIERRKAMSTHGKSAINSSDRTRTDVKSDIKVNKVISTEKPQALKDHNNNIKDNQVVKQNIKRRINQKRKPITNTSRDIVLARREAQSKHGKSASKQNTSAASLARRGDPDLSSREISQRVRELRSKTGSTSKQGNGKCRPCGPNKNGSKLNIADASWKVGKSETDSGQTVTGTQANRSLKTTGNEASTCRTVTGTQYMGAEVTGQFCQDKPKYKQPIRASVTTTTSGNKVTGNEVGRSEKVTGDEPGTCKNLTGTEYISANQSKKYCGEVIKKPSKVMQSITTDGLKVSGSLPGRSSLVTGDESGSGKQLTGDQYLGSEPSPKGKSFEKVGSYDTLNGNNVTGTGVGRSDYVTGNEYGSCKNLTGDEYIGSQQYEKFCGSTPKPEARKVGLSLSSKSNLISGTMTGRSKIVTGDEPGSCKVLTGTPYAGLDQINDNCNAEIADDMKSRATVNSGNNSNARLTGLQPGIGGVMTGATKGSCKNLTGTPYIGGDQFLSNCETPPNDASYANQEKSASNSWKEFSVNSPSREKYSAKNTEGVTGNRYEDSSKITGPFDMAEDKVTGTEQFRFEPNKNMTYKQKMKQEESQNIDIPTDKKEPSKITGEGQSAGNITGDDWDRGDKVTGTEGVSARKRNPSRAGFMGAMPPVDNKRNDETEKPDFLITGSSGNTRDGQLVTFSGGARG
What is the function of this protein?
Required for alpha-carboxysome (Cb) assembly, mediates interaction between RuBisCO and the Cb shell.  The protein is probably highly flexible (Probable).  The C-terminal repeats act as the encapsulation signal to target proteins to the Cb; they are necessary and sufficient to target both CsoS2 and foreign proteins to the Cb.  The N-terminal repeats of this protein bind simultaneously to both subunits of RuBisCO.  Probably also interacts with the major shell proteins (CsoS1); that interaction would increase the local concentration of CsoS2 so that it can condense RuBisCO and full carboxysomes can be formed (By similarity).  There are estimated to be 163 CsoS2 proteins per carboxysome; unlike H. neapolitanus only 1 form is seen (PubMed:22155772).
What are the official names of this protein?
Carboxysome assembly protein CsoS2, Carboxysome shell protein CsoS2.
What is the protein family that this protein belongs to?
Belongs to the CsoS2 family.
What are the subcellular locations of this protein?
Carboxysome. Note=This bacterium makes alpha-type carboxysomes.
Protein: RUVB2_SYNJA
Sequence: MAIISSRAAGAEDPGQRQQKSSARRRESKLAFARAEGLLQPQAHPSEAQEESLRPRTLAEYIGQTELKEVLSIAIAAARARGEPLDHLLFYGPPGLGKTTVAAVLAAEMGSRFYMTTAPALESPRDIAGYLVRLKQGDVLFIDEIHRLPKVTEELLYPAMEDFRLDITVGKGRSARITSIPLERFTLIGATTRIGALTSPLRDRFGQVQRLRFYEPHELAEIVLRSARLLNTSIDRAGAEEIARRSRGTPRIANRLLKRVRDYAQVRGDGHISREVAAAALELFQVDPMGLDWTDRKLLTVLVEQFGGGPVGLETMAAVTGEDPQTIEEVYEPYLLQIGYLQRTPRGRVVTPAALQHLGYTAQSPLPVWS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB 2.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: CYSG_XYLFM
Sequence: MTANALFPLFANLHDRAVLVVGGGKVAERKTEALLKVGALPIIGAPSLTTSLQRWAETGRITWRQGTFEDSWLQEDIWLVIAATDQPEVNHAAARAAHAQRLFVNVVDDIALSNVQVPAVVERGPLRIAISSGGGAPMVARYLRQQLESLIDDSWGRLTTLFAQRRDTIRARYPNIEARRRFFETQLAGPLQRLLRKQRHAEAEAVLEAALAETPLTESGSVTLVGAGAGDAGLLTLNALRALNEADIILYDRLVSDTVLQMARRDAEQIEVGKSATGHSVRQEDIHTLMLQHAHAGQRVVRLKGGDPFVFGRGGEELEFLRTHGIPYEVIPGITAALACAAYAGIPLTHRDHAQSLCLITAHCQSSLDTLDWAALAQERQTLTFYMGVAGLPTIQQRLCEAGRAETTPFALIENGARAQQRVLTGTLKTLAHTAQTYAVRPPALLILGEVTALAEHLHWFGTAPLSAPCPPARIL
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: RLMF_ECOLU
Sequence: MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADYIHHLADLLAEATGSIPANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISANPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHDSAAAARAGSERKRRNLGLNKDDVLNFGGQQQELWCEGGEVAFIKKMIEESKGFAKQVMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLPK_SHESM
Sequence: MQKKYVVALDQGTTSSRAIVFDHDANIVSVSQREFTQLYPNPGWVEHDPMEIWASQSSVLIESLARAGIHSDEVAAIGITNQRETTIIWEKATGKPVYNAIVWQCRRSSEICEQLKAQGLEDYVRENTGLLLDPYFSGTKIKWILDNVPDARAKAKRGELLFGTVDTWLLWKLTEGKVHVTDPTNAARTLLFNIHSLSWDTTLLEALDIPAAMLPEVRPSCSVYGTTRIAGEGSEIPLAGIAGDQQAALFGQLCVEPGMAKNTYGTGCFLLMNTGNKAVRSSHGLLTTVAVGAQGEVNYALEGSVFMGGATIQWLRDELGLIRDASDTEYFASKVADTNGVYLVPAFVGLGAPYWDPNARGALFGLTRGANRNHIIRAALESIAYQSKDLLDAMIKDSGERLKSLKVDGGAVANDFLMQFQADITDVEVLRPSVCETTALGAAFLAGLAVGFWTSVTELEYKACIDKHFKPNIDASQRERLYVGWQDAVVRTRS
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: ERPA_AZOVD
Sequence: MTVETFTPTPLLFTQGAANKVKTLISEEGNPRLKLRVFVTGGGCSGFQYGFTFDEDVAEDDTIVEREGVSLVVDPMSFQYLAGAEVDYQEGLEGSRFVIKNPNAATTCGCGQSFSV
What is the function of this protein?
Required for insertion of 4Fe-4S clusters for at least IspG.
What are the official names of this protein?
Iron-sulfur cluster insertion protein ErpA.
What is the protein family that this protein belongs to?
Belongs to the HesB/IscA family.
Protein: NUOI_ANAMM
Sequence: MRRVMVLFGVVIAGVKGFMLTLVSMFRPKVTLRYPSEKGPLSTRFRGEHALRRYDDGEERCIACKLCEAICPAQAITIEAAERGDGSRRTVRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEYATETREELMYNKEKLLCNGDVWEEALDFRIRKNRPYY
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: CTC1_PONAB
Sequence: MAAGRAQVPSSEQAWLEDAQVFIQKTLCPAVKEPNVQLTPLIIDCVKTVWLSQGRNQGSTLPLSYSFVSVQDLKTHQRLPCCSHLSWSSSAYQAWAQEAGPNGNPLPREQLLLLGTLTDLSADLEQECRNGSLYVRDNTGVLSCELIDLDLSWLGHLFLFPCWSYLPPARWNSSGEGHLELWDAPVPVFPLTVSPGPVTPIPVLYPESASRLLRLRNKLRGVQRNLAGNLVRLSALVKSKQKAYFILSLGRSHPAVTHVSVIVQVPAQLVWHRVLRPGTAYVLTELRVSKIRGQRQHVWMTSQSSRLLLLKPECVQELELELEGPLLEADPKPLPTPSNSEDKKDPEGLARYSRLLSYSGAVTGVLNEPAGLYELDGQLGLCLAYQQFRGLRRVMRPGVCLQLQDVHLLQSVGGGTRRPVLAPCLRGAVLLQSFSRQKPGTHSSRQAYGASLYEQLVWERQLGLPLYLWATKALEELAGKLCPHVLRHHQFLQHSSPGSPSLGLQLLVPTLDLLAPPGSPVRNAHNEILEEPHHCPLQKYTRLQTPSSFPTLAALKEEGQREAWASFDPEALLPLPEASHLPSCQLNRHLAWSWLCLLPSAFHPAQVLLGVLVASSHKGCLQLRDQSGSLPCLLLAKHSQPLSDPRLIGCLVRAERFQLIVERDVRSSFPSWKELSMPGFIQKQQARVYVQFFLADALILPVPRPSLHSATPSTPQTDPTGPEGPHLGQSRLFLLCHKEALMKRNFCVPPGASPEVPKPVLSFCVLGSWLGGTQRKEGTGWGLPEPQGNDDKDQKVHLIFFGSSVRWFEFLHPGQVYRLVAPGPPTPMLFEKDGSSCISRRPLELAGCASCLTVQDNWTLELESSQDIQDVLDANKALPESSLTDLLSDNFTDSLVSFSAEILSRTLCEPLVASLWMKLGNTGTMRRCVKLTVALETAECEFPPHLDVYIEDPHLPPSLGLLPGARVHFSQLEKRVSRSHNVYCCFRSSTYVQVLSFPPETTISIPLPHIYLAELRQGGQSPFQATTSCHIVSVFSLQLFWVCAYCTSICRQGKCTRLGPTCPTQTAVSQAIIRLLVEDGTAEAVVTCRNHHVAAALGLCPREWASLLEFVRVPGRVVLQFAGPGAQLESSARVDKPMTMFLWTLCTSPSVLRPIVLSFELERKPSKIVPLEPPRLQRFQCGELPFLTHVNPRLRLSCLSIRESEYSSSLGILASSC
What is the function of this protein?
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex.  The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves.  Initially the CST complex has been proposed to protect telomeres from DNA degradation.  However, the CST complex has been shown to be involved in several aspects of telomere replication.  The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity.  The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha.  The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins.  Involved in telomere maintenance.  Involved in genome stability (By similarity).  May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity).
What are the official names of this protein?
CST complex subunit CTC1, Conserved telomere maintenance component 1.
What is the protein family that this protein belongs to?
Belongs to the CTC1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere. Note=A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
Protein: GLPK_SHESW
Sequence: MQKKYVVALDQGTTSSRAIVFDHDANIVSVSQREFTQLYPNPGWVEHDPMEIWASQSSVLVEALARAGIHSDEVAAIGITNQRETTVIWEKATGKPIYNAIVWQCRRSAEICEQLKAQGLEEYVRENTGLLLDPYFSGTKIKWILDNVPNAREQADRGELLFGTIDTWLVWKLTEGKVHVTDPTNAARTLLFNIHSLTWDNKLLEALDIPLSMLPDVKPSCSVYGTTRIAGEGSEIQVAGMAGDQQAALFGQLCVEPGMAKNTYGTGCFLLMNTGTKAVRSNHGLLTTVAVGPKGEVNYALEGSVFMGGATIQWLRDELGLIRDASDTEYFASKVADTNGVYLVPAFVGLGAPYWDPNARGALFGLTRGANRNHIIRAALESIAYQSKDLLDAMIKDSGVSLKRLKVDGGAVANDFLMQFQADITDVEVLRPSVCETTALGAAFLAGLAVGFWESVIELEHKACIDKHFIPNIDAQTRVQLYAGWQDAVARTRT
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: MATK_CUSRE
Sequence: MSLVQIQLKTEDFKIYLQLPVRSQQHNFIYPLLFQEYIYVLVHDRDLKRSIFFANIGYEKKFRFQIVKRLINRMYKQIHLTTYYSNYSNKRTIYGLLKSFYYKLLSSGFSFLFEIPFFFKFISERKKILKSQNLRSIHSIFTFFEDNLSHLKYVLDLLIPNPPHPEILVQKIRYWVQDASSLHLLRFFLHEFCSVKSLITTNKSKRNERFLFLLYNSYICEYESIFLVLRNQSLHLGSMSFVTLFERNIFYGKIECFAELFAQDSQANLRLFKDTDPSMHYARYRGKSILASNGGLLLMPKWKYYIVNFWQCYFYLWFHTERINISQIDSHPFYLMDYISSIAQIPSMVRSKMLENLFLINNDMKIFETFVPIIPIIGSLAKAKFCNLLGNPISKPVWADFSDSDIIERFGRICRNIFHYYSGSSKKRSLYQIKYILRLSCARTLARKHKSTLRGFLQSLGLKLLEEFFTSEEQIIFLTFPNASLNLRGVSKGRIWYFDIVYINEQANF
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid.
Protein: ZDHC8_MOUSE
Sequence: MPRSPGTRLKPAKYIPVATAAALLVGSSTLFFVFTCPWLTRAVSPAIPVYNGILFLFVLANFSMATFMDPGVFPRADEDEDKEDDFRAPLYKNVDVRGIQVRMKWCATCHFYRPPRCSHCSVCDNCVEDFDHHCPWVNNCIGRRNYRYFFLFLLSLSAHMVGVVAFGLLYVLNHSEGLGAAHTTITMAVMCVAGLFFIPVIGLTGFHVVLVTRGRTTNEQVTGKFRGGVNPFTRGCYGNVEHVLCSPLAPRYVVEPPRMPLSVSLKPPFLRPELLERAVPLKVKLSDNGLKAGRSKSKGSLDQLDEKPLDLGPPLPPKIEAGTFGRDLKTPRPGSAESALSVQRTSPPTPAMYKFRPAFSTGPKTPFCGPNEQVPGPDSLTLADDSTHSLDFVSEPSLDLPDHGPGGLRPPYPPSPPLNTTDAFSGALRSLSLKAASRRGGDHMTLQPLRSEGGPPTPHRSLFAPHALPNRNGSLSYDSLLNPGSPSGHACPTHPSVGIASYHSPYLHPGPSDPPRPPPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQTDSLFGDSGVYDTPSSYSLQQASVLTEGPRGSVLRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSMSRAPRTSSSSLQADQANNNAPGPRPGSGSHRSPARQGLPSPPGTPRSPSYTGSKAVAFIHTDLPDRQPSLAMQRDHPQLKTPPSKLNGQSPGMARLGPAASPMGPNASPARHTLVKKVSGVGGTTYEISV
What is the function of this protein?
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes.  Through the palmitoylation of ABCA1 regulates the localization of the transporter to the plasma membrane and thereby regulates its function in cholesterol and phospholipid efflux (By similarity).  Could also pamitoylate the D(2) dopamine receptor DRD2 and regulate its stability and localization to the plasma membrane (By similarity).  Could also play a role in glutamatergic transmission (PubMed:15184899).
What are the official names of this protein?
Palmitoyltransferase ZDHHC8, Zinc finger DHHC domain-containing protein 8, DHHC-8.
What is the protein family that this protein belongs to?
Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Protein: RL14_YERPP
Sequence: MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGIGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVILNNNSEQPIGTRIFGPVTRELRNEKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: UVRC_GLUOX
Sequence: MTDLPPHSSHHPADQGEPLVPAEKKQGVEAIREALKTIPYSPGVYRMLSEKGEVLYVGKALSLKKRVSSYIRINQLPERLRRMVSMTVSMEIVITRTEADALLLEANYIKRMKPRFNILLRDDKSYPWLMLTESHEFPQITKQRGKPVKGATYWGPFANAWAVNQTLNLVQRSFLLRSCSDAVLNSRTRPCLLYQIKRCSAPCVDRISKEDYAELVSEARQFLSGHSTELQQRLVAEMEQASQELNYERAASIRDRIRGFASIQGSSTINPTSINDADIMTIWQEAGQSCIQVFFIRGSRNNGNRAFYPAHAEEETAADVLSAFMIQFYDNKPPPPSILVNCELPEPKLVEEALSIRRGQKVEILRPQRGEKKDVVEHAALNAREALERKLAENTGQRRLLEGVAEVFGLPEIPQRIETYDNSHIMGQAPYGVMVVGGPEGFNKRAYRKYAIKGPVTPGDDFGMMREVMERRFGHRSENGERPEDWPDLLLIDGGLGQFNAVRAVLADLGVTGIPIVAIAKGPDRDAGREWFFTETKSPFQLPPRDPVLYYLQRLRDEAHRFAITTHRAGRSKGLRSSELDHVPGIGAARKKALLNHFGSAKSVRQASLEELENAPGISSSTATAIYGHFHPEWVQKTSADNRSH
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.