PharMolix/UniProtQA huggingface dataset:
Protein: RUVC_CHLTR
Sequence: MADLIMGIDPGTLVCGYALIKVENRYHIHPHSFGKVKLSQKLALAHRYKQLFTEISTILQQESPKAVVLETQYVHKNPQSTIKLGMARGVLLLAASLQDVPVFEYAPNTAKKAAVGKGNASKKQVQLMVSKLLRVPDLLAEDNEDIADAFALAMCHAHLAPYQDLKKTLV
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: Y3281_KLEP7
Sequence: MSIQNEMPGYNDVYQLLNQQGVGLTPAEMHGLISGLLCGGNTDSSWQPLVHDLTNEGLAFGHELAQALRNMHSAISDSLDDDGFLFQLYLPEGDAVSVFDRADALAGWVNHFLLGLGVSQPKLDKVKDETGEAIDDLRNIAQLGYDEDEDQEELEMSLEEIIEYVRVAALLCHDTFARQQPTAPEVRKPTLH
What are the official names of this protein?
UPF0149 protein KPN78578_32810.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: PYRB_CALBD
Sequence: MKHLLGLRELSKEDIIKILNLAKDMKTILKSETKKTPHLQGYSVVTLFYENSTRTRTSFELAAKFMSANTTSISVQTSSVQKGESLLDTVKTLEALKTDVLIVRHAVSGVPHFIAKNCSFSVINAGDGMNEHPTQALLDMFTIRERLGTIERLKIAIIGDIFHSRVARSNIWGLSKFDNQITVFGPQTLIPPYIENFAYVASSLEEAVSGKDVVIDLRIQLERQKRGFITSKQEYYKFYGLNEDIMRYISGSTLIMHPGPVNRGVEISSEVLQLPNSTIDEQVTNGIAVRMAVLYLCTRKEGIYR
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: RLMKL_SHESW
Sequence: MLNFFAAAPKGFEYSLAQELTEFGATEIKESVAGVYFTAPLTLAYRITLWTRLASRIVLVIYKGSCESAEQLYNAAYCIDWPAHFSNRNTFSIDFHGTGGFINNTQFGALKIKDAIVDRFRDDGDERPNVSRTDADFKVDAHFRNGVITIAMNFSGPSLHQRGYRSTTGEAPLKENLAANMLVRSGWQAAPTTLLDPFCGSGTVLIEAALMAADIAPGLQRNRFGFEHWRRHDKAVWQDIVAEAKARASLGVKRCEIKFYGSDIDSRLVALAKRNAENAGVLELIEFKVANALNIEPPAAEGYLITNPPYGERLGNVSELLQLYYQLGDKFKKEFGGWKVAMLCSDIELISSLKLKADKQMKMFNGALECAFNLYTLHANSTRRDTPVLPEGVDIADIAPAFANRIKKNAKQLEKWAQKEGIDSYRIYDADIPEYNVAVDKYLDYVIVQEYMAPATIPEAVTKRRLSDVLLALPAAIGINPNKIIMKTRERQKGTSQYQKLDERKLELITTEYGAKFKLNLTGYLDTGLFLDHRLTRRLVGQKAKGRRVLNLFSYTGSASVHAALGGAKSVTTVDMSNTYIAWAKDNFALNGLQGKQYEFVQADCLQWIRDCNEQFDLIFIDPPTFSNSKRMEDSFDVQRDHVNLLSALVKLLSPTGELVFSNNKRKFKMDIETLTKMNITVKNIDDITLPMDYKRNPHIHNTWLITHA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3692_BACCZ
Sequence: MFGQRQSMIVYLHSLKHAKILRKYGNIHYISKRLKYAVVYCDMEQIEHMMQKLNKLPFVKKIEQSYRPYLKTEFENSRPDRAKEYDYS
What are the official names of this protein?
UPF0298 protein BCE33L3692.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU5M_ANOQU
Sequence: MNYCKISFYFLLSISLSLFLISLKFLLKDLVYFIEWEAWVFKSMSIVMTFLFDWMSLMFMSFVLLISSLVIFYSNQYMEEDYNINRFILLVLMFVMSMMMLIISPNLISILLGWDGLGLVSYCLVIYFQNVKSYNAGMLTALSNRIGDVALLLAIAWMLNYGSWNYIFYLEMMSKNTEMMIIGGLVMLAAMTKSAQIPFSSWLPAAMAAPTPVSALVHSSTLVTAGLYLLIRFNILLTDWWMGQFMLLISGLTMFMAGLGANFEFDLKKIIALSTLSQLGLMMSILSMGFYKLAFFHLLTHALFKALLFMCAGSIIHNMKNSQDIRMMGSLSMSMPLTCSCFNVANLALCGMPFLAGFYSKDLILEMVSLSYVNVFSFFLFFFSTGLTVCYSFRLVYYSMTGDFNSSVLHPLNDSGWTMLFSIFFLMIMAVIGGSMLSWLMFLNPSMICLPFDLKMLTLFVCILGGLIGYLLSNVSLFFTNKALYFYNFTYFAGSMWFMPVVSTIGVINYPLKLGLYSYKSFDQGWSEFFGGQMIYNQLKNYSLYLQEFQMNSLKIYLLSYMLWFIVLLMLVVLVN
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: FLGI_ECOHS
Sequence: MIKFLSALILLLVTTAAQAERIRDLTSVQGVRQNSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASLPPFGRQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAVIERELPSQFGVGNTLNLQLNDEDFSMAQQIADTINRVRGYGSATALDARTIQVRVPSGNSSQVRFLADIQNMHVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQANVSQPDTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSASLNNVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: CIDA1_BACCR
Sequence: MKWWKLSGQILLLFCFAWTGEWIAKQAHLPVPGSIIGIFLLLISLKFNLVKKEWIQDGADFLLKELILFFIPSAVAVIRYRDTLTQYGIDLILIIMISTLCVTLVTGLLTELLLKRKGSTQ
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential (By similarity).
What are the official names of this protein?
Holin-like protein CidA 1.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. CidA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NIKD_BRUME
Sequence: MTRKTLAIEGLTATTVIDGQQRVLVDNLSLGVQRGRILALVGASGSGKSMTCSAALGVLPPGVTASRGRVTIDGVPYAANALRGRHVATIMQNPRSAFNPVRTMRDHAIETLQALGKLSSNPQDQIVHCMRAAGLEDVKTILSLHPFEMSGGMLQRMMIALALLSEAPFLFADEPTTDLDLVVQLRVLELLEKLVEERDLGILLVTHDMGVVARLAHDVAVLDHGRLIEQAPVMDIFQTPGHEVTRMLVSAHLSLYGMELNA
What is the function of this protein?
Part of the ABC transporter complex NikABCDE involved in nickel import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Nickel import ATP-binding protein NikD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: FADA_MARMS
Sequence: MKLNPNDVVIIDAVRSPMGKTKNGVFRNVRAENLSAALVKELFKRNPNVDQKDVEDLIWGCVNQTLEQGFNMARAVSLLAGLPITCAAQTVNRLCGSSMSAIHTAAQAIMTGQGDVFVVGGVEHMGHVGMMHGVDVNPALSKHMAKASMMMGVTAEMLGKMHGVSREDQDAFAVRSHRLAHEATLQGRFNNEIVSIEGHDADGNKILVEVDEVIRPETSMESLAKLAPVFMPKVGTVTAGTSSALSDGASAMLMMSAKKAEELGLTPIAKVRSMAVAGCDPAIMGYGPVPATKKALKRAGLTIADIDIVELNEAFAAQSIPVLKDLGLLDLVDDKVNLNGGAIALGHPLGCSGTRISTTLLNVMREKDATVGLATMCIGMGQGIATVFERV
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COAX_AQUAE
Sequence: MRFLTVDVGNSSVDIALWEGKKVKDFLKLSHEEFLKEEFPKLKALGISVKQSFSEKVRGKIPKIKFLKKENFPIQVDYKTPETLGTDRVALAYSAKKFYGKNVVVISAGTALVIDLVLEGKFKGGFITLGLGKKLKILSDLAEGIPEFFPEEVEIFLGRSTRECVLGGAYRESTEFIKSTLKLWRKVFKRKFKVVITGGEGKYFSKFGIYDPLLVHRGMRNLLYLYHRI
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_YERFR
Sequence: MILIEHILGNVKKDPVWQAKLKDATFDLLVLDQREAQKSRCRKLSTQGLDLGISLDRHVVLADGDVLAWDEKTNVAVVVQINLRDVMVIDLSELKSRSPDELIKTCFELGHALGNQHWKAVTKNNEVYVPLTVATTMMDSVMRTHGFQHLPFRFVKGAEILPLLSNSEARLLFGGAEDTDTHVHVASPLDEPHGSGLHIHGIHSHGDGHSHSHDSHSHSHDSDHGHSHSHGDHDHDHKH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCOC2_MOUSE
Sequence: MGGASACIPLCLLLATARMARPQTPERPVFTCGGILTGESGFIGSEGFPGMYPPNSKCTWKITVPEGKVVVLNFRFIDLENDNLCRYDFVDVYNGHANGQRIGRFCGTFRPGSLVASGNKMTVQMISDANTAGSGFMATYSAAAPDGKGDRYCGGRLEKPSGTFKTPNWPDRDYPVGVTCVWHIIAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDAKRIGKYCGDSPPVPIVSERNELLIQFLSDLSLTADGFIGHYKFRPKKFPTTTTTPVTTTLPVTTGLKPTVALCQQKCRRMGTLESNYCSSNFVLAGTVITTVTRGGSLHATVSIISIYREGNLAIQQAGKNMSVKLTVVCRQCPLLRRGLNYIIMGQVGEDGRGKIMPNSFVKMFKNKNQKPMNALKNKQC
What is the function of this protein?
Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.
What are the official names of this protein?
Procollagen C-endopeptidase enhancer 2, Procollagen COOH-terminal proteinase enhancer 2, PCPE-2, Procollagen C-proteinase enhancer 2.
What are the subcellular locations of this protein?
Secreted.
Protein: LEU1_AZOSB
Sequence: MLKNPHTKYRPANPFAGVVPGGRGLSDRTWPDNTITRPPVWMSTDLRDGNQALFEPMNSERKMRMFKMLVEIGLKEIEVAFPAASQTDFDFVRELIEGGHIPDDVTIEVLTQARPHLIERTFESVRGAKRAIVHVYNAVAPNFRRIVFDTDRAGVKQIAVDSARYFVEMAARQPGTDFTFQYSPEVFSGTELDFAVEVANAVIEVWQPTPQQKCIINLPATVEMSTPNVYADQIEWMHRHLARRDSVLLSVHPHNDRGTAVAAAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQGVHPGLDFSRINEVARTVEHCTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGFAVQQPDAVWEVPYLPVDPADLGRSYESIIRVNSQSGKGGIAYLLEAEYGLVMPRRLQVEFSAAIQRITDERGTELSAGDIWRAFEEEYLAVAAPYAYVEHHLAEHGGQQGISLTVEEAGVRRVLRGVGNGPIDAALHALDAGAVLLGYEERAIGQGGDARAVAYIELADGEGGGSTFGVGIHANIVTASVLAIVSALDRLAQRRERADGVGRQVAATR
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: RNH2_PSEAE
Sequence: MQLGLDFNLVEDLVAGVDEVGRGPLCGPVVTAAVILDPSRPILGLNDSKKLSEARREALFEEIREKALAWCIARAEVEEIDRLNILHATMLAMQRAVEGLSVIPRLALIDGNRCPKLAVPCAPVVKGDSQVPAIAAASILAKVSRDREMVELDRVYPGYGMAGHKGYPTAVHLEALSRLGPTPIHRRSFAPVRELLDVSVQ
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CBPA_ECO24
Sequence: MELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQMWQHRNDPQFNRQFHHGDGQSFNAEDFDDIFSSIFGQHARQSRQRPAARGHDIEIEVAVFLEETLTEHKRTISYNLPVYNAFGMIEQEIPKTLNVKIPAGVGNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVGQDLEIVVPVSPWEAALGAKVTVPTLKESILLTIPPGSQAGQRLRVKGKGLVSKKQTGDLYAVLKIVMPPKPDENTAALWQQLADAQSSFDPRKDWGKA
What is the function of this protein?
DNA-binding protein that preferentially recognizes a curved DNA sequence.  It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock.  Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK.  Its activity is inhibited by the binding of CbpM.
What are the official names of this protein?
Curved DNA-binding protein.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DAPD_PHOLL
Sequence: MQQLQSIIESAFENRATLTPATVNHETRDAVTQVINLLDSGKLRVAEKIDGQWVTHQWLKMAVLLSFRINENQIIDGTESRYFDKVPMKFSDYDQTRFEKEGFRVVPPAAARQGAFIARNCVLMPSYVNIGAYVDEGTMVDTWTTVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIEDNCFIGARSEIVEGVIIEEGSVISMGVYIGQSTKIYDRETGEIHYGRVPAGSVVVSGNLPSKDGSYSLYCAVIVKKVDAKTQGKVGINELLRSID
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RFTN1_CHICK
Sequence: MGCGLNKLEKHDEKRPGNIYSTLKRPQVETKIDVSYEYRFLDFTTLNDAELPGSSAIKLSSLRDLPAQLQELYQQGFVLAAVHPFVQPTDEKEKTPQEQIFRAVLIKKTERSPKGGIHSEGYILEVECCSSVNQLSDKKEIPDFIKKIQDAASQGLKFVGIIPQYHSQKNCLVSSSLTPASNNSVQSRDNKNVSNCPEDHASLDGEKIDGINGCSTPAPGEENADQCATSREGRKGEGQAAEEPDCKSAKGSKEQHEHPGGREAPDTQNGVAENETPARCSKPLTDKTEIFTLFNKPKTPQRCSQYYTVTIPMRISRNGQTVNSLEANWLEHMTDHFRKGGSLVNAIFSLGMVNDSLHGTMDGVFLFEDVAVEDNKTTQGYDAIVVEQWTVLKGVEVQTDYVPLLNSLAIYGWQLTCVLPTPIVKTNREGNLSTKQIVFLQRPSLPQKAKKKESKFHWRFSKEDMHNKPMKKSRKTKLSSGEKQTAEKQEFEVTENTRNLAAQLSAASGPGPEQQLDSVINLGNETAGADSRGTLHDGVSEGTCPASADAGDTGGSEVQACPNQSAPNCCEEQEAAGQDCALGPDSCQGIDGAAADVEPSCE
What is the function of this protein?
May play a pivotal role in the formation and/or maintenance of lipid rafts.  May regulate B-cell antigen receptor-mediated signaling.
What are the official names of this protein?
Raftlin, Raft-linking protein.
What is the protein family that this protein belongs to?
Belongs to the raftlin family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Note=Associates with lipid rafts.
Protein: DTL_CHICK
Sequence: MLCRALLLRAAGHRQSSSLPLQHLLDGYRCSREDDHLSYGEIGMPVPPFGCSFSAAPNFEHVLAVANEEGFVRLYDTEAQNTTKLISKEWQAHSNAVFDLAWVPGEHRIVTASGDQTAKVWDVRAGELLGICKGHQCSLKSVAFSRFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNVVDRQTPSKLRKKRQNLRGLAPLVDFQQSVTVVLLQDEHTLISAGAVDGVIKVWDLRKNYAAYRQDPVPSKSFFYPGTSTRKLGYSSLVLDSTGANLFANCTDDSIYMFNMTSLKTFPVAVFSGHQNSTFYIKSSISPDDQFLVSGSSDCNAYIWKVSEPSLPPRILVGHSQEVTSIAWCPSDFTKIATCSDDNTVRIWRLQHYPEEEKSVSNKAKLVGWVTQKKPEEQRGAGRSASPQSTPAKAFSVGSPCASSPRPAACAPSYSGDLPLSTNTPTVSLKTQMATACTPAKLSGASPRTSPKLVPSSKMSIKHWIARTPCSSPEVGKKTPSPRKALAEVTQSLLETSSTPKAQHSQAEKRAKRRLDCSKEDEAGQKCLQDCSCVTELDHVAKKSKLNLCHLAAGQRACDEGSLSLADLDNEHEDSTHSPKELSFPGSLVNPSGTQTPPPVLQSPCERDSDVVDKENSSPERKNWLSALGEKLRTGKAGSPPSSYTSSAKRQEAAVVTTSPKTAVNTSVSMRKICTYFHRKPQN
What is the function of this protein?
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.  The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2.  CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication.  CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing.  KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration.  Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation.  In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).  May play a role in the regulation of the circadian clock (By similarity).
What are the official names of this protein?
Denticleless protein homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat cdt2 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome.
Protein: CAPSH_ADEG1
Sequence: MTALTPDLTTATPRLQYFHIAGPGTREYLSEDLQQFISATGSYFDLKNKFRQTVVAPTRNVTTEKAQRLQIRFYPIQTDDTPNSYRVRYSVNVGDSWVLDMGATYFDIKGVLDRGPSFKPYGGTAYNPLAPREAIFNTWVESTGPQTNVVGQMTNVYTNQTRNDKTATLQQVNSISGVVPNVNLGPGLSQLASRADVDNIGVVGRFAKVDSAGVKQAYGAYVKPVKDDGSQSLNQTAYWLMDNGGTNYLGALAVEDYTQTLSYPDTVLVTPPTAYQQVNSGTMRACRPNYIGFRDNFINLLYHDSGVCSGTLNSERSGMNVVVELQDRNTELSYQYMLADMMSRHHYFALWNQAVDQYDHDVRVFNNDGYEEGVPTYAFLPDGHGAGEDNGPDLSNVKIYTNGQQDKGNVVAGTVSTQLNFGTIPSYEIDIAAATRRNFIMSNIADYLPDKYKFSIRGFDPVTDNIDPTTYFYMNRRVPLTNVVDLFTNIGARWSVDQMDNVNPFNHHRNWGLKYRSQLLGNSRYCRFHIQVPQKYFAIKNLLLLPGTYTYEWVLRKDPNMILQSSLGNDLRADGAQIVYTEVNLMANFMPMDHNTSNQLELMLRNATNDQTFADYLGAKNALYNVPAGSTLLTINIPARTWEGMRGWSFTRLKASETPQLGAQYDVGFKYSGSIPYSDGTFYLSHTFRSMSVLFDTSINWPGNDRLLTPNLFEIKRPVATDSEGFTMSQCDMTKDWFLVQMATNYNYVYNGYRFWPDRHYFHYDFLRNFDPMSRQGPNFLDTTLYDLVSSTPVVNDTGSQPSQDNVRNNSGFIAPRSWPVWTAQQGEAWPANWPYPLIGNDAISSNQTVNYKKFLCDNYLWTVPFSSDFMYMGELTDLGQNPMYTNNSHSMVINFELDPMDENTYVYMLYGVFDTVRVNQPERNVLAMAYFRTPFATGNAV
What is the function of this protein?
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid.  Assembled into trimeric units with the help of the chaperone shutoff protein.  Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid.  Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.
What are the official names of this protein?
Hexon protein, CP-H, Protein II.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae hexon protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.
Protein: COBQ_MYCBT
Sequence: MSGLLVAGTTSDAGKSAVTAGLCRALARRGVRVAPFKAQNMSNNSMVCRGPDGTGVEIGRAQWVQALAARTTPEAAMNPVLLKPASDHRSHVVLMGKPWGEVASSSWCAGRRALAEAACRAFDALAARYDVVVAEGAGSPAEINLRAGDYVNMGLARHAGLPTIVVGDIDRGGVFAAFLGTVALLAAEDQALVAGFVVNKFRGDSDLLAPGLRDLERVTGRRVYGTLPWHPDLWLDSEDALDLQGRRAAGTGARRVAVVRLPRISNFTDVDALGLEPDLDVVFASDPRALDDADLIVLPGTRATIADLAWLRARDLDRALLVHVAAGKPLLGICGGFQMLGRVIRDPYGIEGPGGQVTEVEGLGLLDVETAFSPHKVLRLPRGEGLGVPASGYEIHHGRITRGDTAEEFLGGARDGPVFGTMWHGSLEGDALREAFLRETLGLAPSGSCFLAARERRLDLLGDLVERHLDVDALLNLARHGCPPTLPFLAPGAP
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: ATPH_DAUCA
Sequence: MNPLISAASVIAAGLAVGLASIGPGVGQGTAAGQAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFANPFV
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RL27_THEVB
Sequence: MAHKKGTGSTRNGRDSNAQRLGVKRFGGEVVKAGYILVRQRGTKFHPGVNVARGGDDTLFATIAGVVTFERYGKNRKRVSVYPLEG
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: RF3_STACT
Sequence: MSIKDEIESRKTFAIISHPDAGKTTLTEKLLLFGGAIREAGTVKGKKSGKFATSDWMKVEQERGISVTSSVMQFDYDDYNINILDTPGHEDFSEDTYRTLMAVDSAVMVIDCAKGIEPQTLKLFKVCKMRGIPIFTFINKLDRVGKEPFELLDEIEETLNIKTYPMNWPVGMGQNFFGIIDREQRTIEPFRDEEHLLHLNDDYELEEEHEITKDSTFSQAIDEFMLVEEAGEEFDNEMLLAGELTPVFFGSALANFGVQSFLNAYVDHAPMPNGRITKEAEEVSPFTPDFSGFIFKIQANMDPKHRDRIAFMRIVSGAFERGMDVKLQRTNKKQKITRSTSFMADDKETVNHAVAGDIIGLYDTGNYQIGDTLVGGNQKFSFEDLPQFTPELFMKVSAKNVMKQKHFHKGIEQLVQEGAIQYYKTLHTNQIILGAVGQLQFEVFEHRMKNEYNVDVVMEPVGRKIARWVENEDDIKDKMSTSRSILVQDRYEQKVFLFENEFATRWFEEKFPEIKLYSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KLH42_HUMAN
Sequence: MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLLGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWEAFRRFPAFGHNLLVSSLYLPNKAET
What is the function of this protein?
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis.  The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1.  Involved in microtubule dynamics throughout mitosis.
What are the official names of this protein?
Kelch-like protein 42, Cullin-3-binding protein 9, Ctb9, Kelch domain-containing protein 5.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Predominantly in mitotic cells. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase cells is localized between the two sets of separated chromosomes as well as at the spindle poles. During telophase is localized arround the nuclei of the two daughter cells. Not detected at the midbody region during cytokinesis.