PharMolix/UniProtQA huggingface dataset:
Protein: RRF_STAA3
Sequence: MSDIINETKSRMQKSIESLSRELANISAGRANSNLLNGVTVDYYGAPTPVQQLASINVPEARLLVISPYDKTSVADIEKAIIAANLGVNPTSDGEVIRIAVPALTEERRKERVKDVKKIGEEAKVSVRNIRRDMNDQLKKDEKNGDITEDELRSGTEDVQKATDNSIKEIDQMIADKEKDIMSV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCF4_CUCSA
Sequence: MNWRSERIWIEFLRGSRKISNFCWAFILFLGSLGFLLVGTSSYLGRDLISLFPSQQIIFFPQGIVMSFYGIAGLFISSYLWCTILWNVGSGYDRFDRKEEIVSIFRWGFPGKNRRIFLRFLMKDIQSIRIEVKEGIYARRVLYMEIRGQGAIPLTRTDQNLTPREIEQKAAELAYFLRVPIEVF
What is the function of this protein?
Seems to be required for the assembly of the photosystem I complex.
What are the official names of this protein?
Photosystem I assembly protein Ycf4.
What is the protein family that this protein belongs to?
Belongs to the Ycf4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DAPE_PSEE4
Sequence: MTAPAELSPTLQLACDLIRRPSVTPVDADCQTQMMNRLGAVGFQLEPMRFEDVDNFWATHGTQDGPVLCFAGHTDVVPTGPVQQWQHEPFEALIDADGMLCGRGAADMKGSLASMVVASERFVQDYPNHRGKVAFLITSDEEGPAHHGTKAVVELLKARNERLDWCIVGEPSSTTLLGDVVKNGRRGSLGAKLTVRGKQGHVAYPHLARNPIHLAAPALAELAAEHWDEGNAFFPPTSFQISNLNSGTGATNVVPGDLTALFNFRFSTESTVEGLQERVAAILDKHQLEWSIDWALSGLPFLTEPGELLDAVSSSIKAVTGRETQPSTSGGTSDGRFIATMGTQVVELGPVNATIHQVDERILASDLDLLTEIYYQTLVRLLA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: HIR3_GIBZE
Sequence: MPAFQAINLEPEDNIDEQIDTTKEIHVDEALKRFQHALKLHAQGPRSREAAEAAYNELFESEIFKYREAKTDYERAERYADGQPEVSNLDPSLTDGGLDVDAGGADGVAASLAQALYLSYKNYGQFFVDKFKDASTSDTAWKEKAQLKYHDDGRKVLDSWMTALDQDPSDPELWRKAARFAGAINSNRIKRYCLEAAIELDDDPAVMELDPPSLAEGMAGEQLKDQLKLLGDDMALSHPIMAPWLKKKMPALLKRHLDPIPFLPDPTKSLIPPKVSDTQAQTQEDTEMGDADNASLTEPKSVSSWAELGAKLINCLETTAEAFDTCDGIVESSLEDVPIETPPNEIESVASEIEVAVTKPTETEKSPEKDSTPKEQKAGSEGTEDSQKTADQSQKDSNGASARKRSQSAAGLPDGAEEENAMEKRSKRVRRRETLQAEETTDPNTLIANQLQPYQGADQNLFQMTKSVLEHLGVEDKSTFAFITELIDSCATENRPGKITNLAACDLSSVIVNFREEVAKVFLHKNEQASLGPSSFLEHAKTGSQDQPSMPSFNEKQGLRSFARKIGGCRSWMTAEDVAYEWVRAVSQSYATAKWSDKMKLSVVQMLNKVDSTLYRKITEEMELAAGSAERLADLETIVPMLFELHVDIYELITNPSSVVDYATRMDTKYRLGRWLDIASAYLRLIDRPANDPLIARFLWASVLVSSHAEQPLREHILLMWTSLRDHLADEKVPAISLPNNVVMPTISPAAADREISKLTTMDFFLGLFQDNMDDPVFVIDTLEPVLNPSTVCAPNQGTDSESGEDSDSSASSDTTGASTLDSSDDSTDDNDESSDASSNQKQKKSISDCASQSLKDLWKFLHNSSTELRLFLWSRLGDAYDAINYSTKKFSCCLKSIELIVSDLEGETYANTVPESRRLLFMRTLKSLDELLITALGSALNDNTAFEIIDDAHIRSTSAALAKVNCLLHVASLCEDEVRIGIKPERTGNAASKAAFQALKNKLKEMQIRAWCLQYTMFKAGINKDNCIIGPENDLADYLAAIHQVIGIRKFCKASNKIFLKVMRVELLKLKNIENWEDYLGQVLYDLHGLKLGAGVWEVQDHACPPEKLEKRQTMQLVERVCILANRMPMKDLLKSDLKTTIDHMQQTIGQTKSTPQMYHNLRNFTEYLKKPIHPLRLYRALIGDVSVDAVSVNTPETILATHGWFFLLGMMALTKFKGVELNRRQTPGATDDLRIGATFLRLQLQFTADRWDAWFRLAECFDYELDEAVLWTADKMNKERPELVKFQRNAIHCYTLALSHSRNLDIETHDGDPLHDLYHKFAMRMYASSREPFAMEPFQHSDQERYFIEDMGIGTFKRILHSQMNKYKVWKFAAKLFRMAMDRKPDNWKNPYMLSKCYWKMYQTPDDQLDVKDITSKIGLMTLIDTLKKAVEVAHNARRGRNTDPIFEPHYKIVTILHKLVIRGDVPAKDAAEILSEQPFGLEVNPDDHFASFSALEDWEEYIIRNLSKLKEKDKANWQHRIIIRHAKILFDEATEVSSEDRLVNAKAAFGVLRDSMFTKTMVMNVWKCDAERPGRHHVYTEQYVRLMTKLLVIMNDRGNLEQLLRRLRKKGADFYHFTDLWQSCCMAYLKLLRQGYNVSPVADDAFKALSSEEFEVVGERIADWAASDGAENPLFNCMKEAIEFKKLNANLMKVAPIDDLLYDCYSRIYSEIAKTLPGPDPSKVVEERHHAKEVAAQLEAAQTETKVTSSLASILNAPNGQESITGTATPMETEKQEAAPRSRKTGVRRPDVLRKAEQAVIRALEAPKPNKSRVGSVSSGKRGSRTPNQRASDAGSEEDGPDSQIRREAGHDGDVDMKDAGDENEEDHGEEEHDEENEDEQDEEHDEAAEDENAEEHGVEEKADSETGSIEDSADDESDLSDVPEDYDEEVPPGLRFSNLGHQSEESSGEDADSESEGDDEAEESDGEEEAEEEAEGEETLGIEDTELADEDEDEDEEQPKRSGSWAANDSIRAVGW
What is the function of this protein?
Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.
What are the official names of this protein?
Histone transcription regulator 3 homolog.
What is the protein family that this protein belongs to?
Belongs to the HIR3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SRFP1_ORYSJ
Sequence: MELDDASRHGFGRMGFGCKHYRRRCRIRAPCCNDVFHCRHCHNESTKDGHELDRHAVESVICLVCDTEQPVAQVCYNCGVCMGEYFCSACKFFDDDVDREHFHCQDCGICRVGGKDNFFHCEKCGSCYSVSLRDKHCCIENSMKNNCPICYEYLFDSLRETSVLRCGHTMHLQCFHEMLKHDKFSCPICSMPIFDMDKFLRALDAEIEANMLHIDYMGKGWIVCNDCRDTTQVYARVAGHKCCHCQSHNTCRVAAPVLPA
What is the function of this protein?
Possesses E3 ubiquitin-protein ligase activity in vitro.  Possesses transactivation activity in yeast cells.  May modulate abiotic stress responses by negatively regulating antioxidant enzymes-mediated reactive oxygen species (ROS) removal.
What are the official names of this protein?
E3 ubiquitin-protein ligase SRFP1, OsSRFP1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Localizes predominantly in nucleus.
Protein: LRP_KLEPN
Sequence: MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFEQFNSAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
What is the function of this protein?
Mediates a global response to leucine.  Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons.  For example it is regulator of the branched-chain amino acid transport genes.
What are the official names of this protein?
Leucine-responsive regulatory protein.
Protein: ODO1_OCEIH
Sequence: MAENAESAERFWGQFHGQNTGYLEQQFELYKEDPELVESSIRTIFDTHGAPSWLSSTENVKSVSNASDFDVTKLTSAIRLVEAIRRYGHTDADIYPVGGYKGDRSKMLDLSTYNLKEQDLEKIPASWIWEKQAPGVATALDVVNQLKKYYTGTITFEYDHVNNDEERKWLFDLIEEGNARLDPSDDERKKILQRLADVEGFEKFLHKTFVGQKRFSIEGLESMVPMIDHIVQYSNQDSIEHVMMGMAHRGRLSVLANVLGKPYDKIFSEFNYTKEKELMPSEGSRAINYGWTGDVKYHYGAEKEVEFGNKGQTRITLAHNPSHLEFVNPVVEGFTRAAQDDRSEKGYPKQVTNKAVSVLIHGDAAFIGEGVVAETLNLSGLPGYSTGGTLHIIANNLLGYTTDREDGRSTRYASDLAKGFEIPVIRVNADDPISCISAIKIAYEYRQKFQKDFLIDLVGYRRYGHNEMDEPRTTQPSLYQQIDDHPSVASLFGKGMEEKGILQEGGFEEVKSAVEKKLTDIYKGMTESEIGEPEAKLMPQVLTNGLDQFTTAIDLATLKSINEELLERPEGFKGFKKTERILQRRKDALEEGNKADWGTGEALAFASILKEGTPIRLTGQDTERGTFAHRHIVLHDVETGEKYSPLHGLSDVEASFDVRNSPLSEAGVLGFEYGYSVQSPDTLVIWEAQFGDFANAGQVIFDQFISSARAKWGEKSNMVLLLPHGYEGQGPEHSSARLERFLQMAAENNWIVANVTSSAQLFHILRRQAAMRDRDEARPLVLMTPKSSLIRHPRMGATAEEFTDGGFLALRDQPGFEANREKVTRLVVGSGKMMIDIEEAMDDSDETYDWLQIKRVEQIYPFPKKALEEEIKQLPNLKEIVWVQEEPKNMGAWNFVDDYLRELLNEDQKLKVISRPDRSAPAGGIPTVHKTAQNKIIKQALNQSEGGKSSAGN
What is the function of this protein?
E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
What are the official names of this protein?
2-oxoglutarate dehydrogenase E1 component, Alpha-ketoglutarate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
Protein: MOAE_ECOLI
Sequence: MAETKIVVGPQPFSVGEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVNALTLEHYPGMTEKALAEIVDEARNRWPLGRVTVIHRIGELWPGDEIVFVGVTSAHRSSAFEAGQFIMDYLKTRAPFWKREATPEGDRWVEARESDQQAAKRW
What is the function of this protein?
Converts molybdopterin precursor Z to molybdopterin.  This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group.  The sulfur is provided by MoaD.
What are the official names of this protein?
Molybdopterin synthase catalytic subunit, MPT synthase subunit 2, Molybdenum cofactor biosynthesis protein E, Molybdopterin-converting factor large subunit, Molybdopterin-converting factor subunit 2.
What is the protein family that this protein belongs to?
Belongs to the MoaE family.
Protein: DGGGP_THEPD
Sequence: MKSSLPGALFQRVADWLRLLRAGNCAVVSLGAYTGYVAGRGGSLPQGVLVAASAALVAAWGNIVNDYFDLESDAISKPWRPLPSRRISPGSAVSASLPLLAAGLALGFLVSPLCGFTAVLASALLFLYSWRVKALGLPGNVLIAFLAALNVVYGALASPEPWRSLLPSAYAFLIILGREVLKGVEDLEGDAARGVKTVASTLGARAALRVSAVLLLAVVALSPLPLLSGYGALYALFAFGGVDAPIALALLKAGPEPRRAWIATRILKVPLLMGLLAFLVGGLA
What is the function of this protein?
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP).  This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
What are the official names of this protein?
Digeranylgeranylglyceryl phosphate synthase, DGGGP synthase, DGGGPS, (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase, Geranylgeranylglycerol-phosphate geranylgeranyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MIAA_SHISS
Sequence: MSDISKASLPKAIFLMGPTASGKTALAIELRKILPVELISVDSALIYKGMDIGTAKPNAEELLAAPHRLLDIRDPSQAYSAADFRRDALAEMADITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRARIEQQAAEQGWESLHRQLQEVDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIEQRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYLEGEISYDEMVYRGVCATRQLAKRQITWLRGWEGVHWLDSEKPEQARDEVLQVVGAIAG
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: SO6C1_MOUSE
Sequence: MAHVRNKKSDDKKAMVVAKEDTNKSESEGVTKLQTYLKTIPIAKKKFAKLPKRKKSPTSAELLLIDPRYSASKEGPLGLGPIVLPFVQRFNNIDGFMTLYVAAVLIHGALFAVVDMTLNIYQVQFSLTRTEWYLMDFSDYIASFVVAIIIAHFGSKGNRTRWIAASCILMGLESMLFAFPFFTYEIIIPGRQSIELCMEENEKRNIICGNSVPNRSKCIYFHIAGQCIHGIAGMPIYILGITFIFDHIPTSSCGFYLAIGHSAYLIGYLLGMVGGLQNFQPPPKEKTVEIEPAKVYQLLQSGWWKTFLIIAAISFCVSFMMVCFPTSLPGAHKLRLAKRKEPPTIDRRLKDMKIQPHLKGFLHNIWHILKNPLMLTQAICKVSEYLTFNTSLYFLPHHLQTQFLITPGIASLLTGAFVLPGGIIGHFLGGLIVDRLEMTNKNKLKFTLVTTVVSVGLFLLIFFVECQTTTFAGINEDYDGYGQLGNLTADCNEYCDCTTSLYTSICGRDEKEYFSPCFAGCKATKVSQTEKTYYNCSCIKEGLAASDDEGQFIDAIAGTCDSDCLKLPLFFAFYFSATVFSNMCSIPVISIILQSVPANFTSLSLGVTYAIVKFVASVPAPLLFRLSSAIACIYWDNNRCGGKERCWIYNKNILVYEFMGIWMSSQLIIVLLNIYAIQIHDVVVHGEITESKTTVKDVKEQKERKA
What is the function of this protein?
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.
What are the official names of this protein?
Solute carrier organic anion transporter family member 6C1.
What is the protein family that this protein belongs to?
Belongs to the organo anion transporter (TC 2.A.60) family.
What are the subcellular locations of this protein?
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein.
Protein: CP144_MYCTO
Sequence: MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ
What are the official names of this protein?
Cytochrome P450 144.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: SYS_VIBCH
Sequence: MLDSKLLRTELDETAAKLARRGFKLDVETIRTLEEQRKSIQVEVENLQSTRNSISKQIGQLMASGDKAGAEAVKQQIGTLGDDLDAKKVELDAVMAQLDAITQTVPNIPDDAVPNGKDDSENVEVSRWGTPKTYDFEVKDHVDLGEMGDGLDFASATKITGARFVVMKGQFARLHRAIAQFMLDLHTDQHGYTELYVPYLVNAETLFGTGQLPKFGQDLFHTEPLTEKASDEEPRRLSLIPTAEVPVTNLVRDTILDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITRPEDSMAALEELTGHAEKVLQLLELPYRKVILCTGDMGFGSCKTYDLEVWVPAQKTYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENYQEADGRIAIPAVLQKYMGGLTHIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KNOX3_HORVU
Sequence: MEEIGHHFGLGATAHGQHHSQLPWGSSPLSAVISPPPQQQQQHQQQSAGYLAHSPLSLNTAPPGVSHGGGSGCSNPVLQLANGSLLEACAKAAKEPSSSSYAADVEAIKAKIISHPHYSSLLAAYLDCQKVGAPPEVSARLTAVAQDLELRQRTALGGLGTATEPELDQFMEAYHEMLVKYREELTRPLQEAMEFLRRVETQLNSLSISGRSLRNILSTGSSEEDQEGSGGETELPEIDAHGVDQELKHHLLKKYSGYLSSLKQELSKKKKKGKLPKEARQQLLSWWEMHYKWPYPSESQKVALAESTGLDLKQINNWFINQRKRHWKPTDEMQFVMMDAYHPPNAAFYMDGHFVNDSGLYRFG
What is the function of this protein?
May play a role in meristem formation and/or maintenance.  Overexpression causes the hooded phenotype characterized by the appearance of an extra flower of inverse polarity on the lemma.  Binds to the DNA sequence 5'-TGAC-3'.
What are the official names of this protein?
Homeobox protein KNOX3, Hooded protein.
What is the protein family that this protein belongs to?
Belongs to the TALE/KNOX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: END4_THEVO
Sequence: MDDDLKSIASKYYIGGHISVSGGLHLAPERASIFGFRTFQFFSKNQMRWNSTPISEEEALRFISEVSSHSISSTMVHASYLINLASSSNELHQKSFNAFVEEIQRAERIDATFLTFHPGSNGNKDEGIRKIKEAIEKVETHKVKLLVENTAGQGNVIGSTIYEIGQIIDGFDSSVGVCIDTCHAWAAGYDITNKYDEFIDELDSAIGLDRIYAFHLNDAMKDLGSNIDRHELIGRGKIGEGLIKLISDVRLFGKPKIMETPYGEAKFEENLKYIRKKLGE
What is the function of this protein?
Endonuclease IV plays a role in DNA repair.  It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
What are the official names of this protein?
Probable endonuclease 4, Endodeoxyribonuclease IV, Endonuclease IV.
What is the protein family that this protein belongs to?
Belongs to the AP endonuclease 2 family.
Protein: RBM20_PIG
Sequence: MVLAAAMSQDAEPSGPEQPDRDARSVPGAPAPPAPPGPRGMQPPPPPPPPPPPPPQAGLPQIIQNAAKLLDKTPFSVSNPNPLLPSPASLQLAQLQAQLTLHRLKLAQTAVTNNTAAATVLNQVLSKVAMSQPLFNQLRHPSMISAPHGHTGVPPHATTVPSTRFPSNAITFSAGQTRGPGPSVNLPSQPPNTMVMHPFSGVMPQTPAQPAVILGIGKTGPAPAAAGFYEYGKATSGQAYGSETDSQPSFLPASASTSGSVTYEGHYSHSGQDSQAAFPKDFYGPTSQGSQVAGTFAADTAGGLKGEVGPLLQGPNSQWESPHGFSGQSKPDLTAAPNLWPPHPSQPYELYDPEEPTPDRTPPSLGGRLNHSKQGFSGARRRAKEEQAVLSMRPLQVQELNDFHGVAPLHLPHICSICDKKVFDLKDWELHVKGKLHAQKCLLFSENTGVRCVLGPAEGTLCASPNSTAVYNPAGNEDYASNLGTSYAALPARTFTQSNPAFPSASPGMNFVQRKLGAGRVVHICNLPEGSCTENDVINLGLPFGKVTNYILMKSTNQAFLEMAYTEAAQAMVQYYQEKSAMINGEKLLIRMSKRYKELQLKKPGKTVAAIIQDIHSQRERDMFREADRYGPERPRSRSPVSRSLSPRSHTPSFTSCSSSHSPPGPSRADWGNGRDSWEHSPYARREEERGPAPWRENGEDKRDRTDMWAHDRKHYPRQVDKTELDERLEGGRGYREKHPRSGSPSSLHSVSGYKSREDGYYRKEPKGKSDKYLKQQQEAPGRSRRKDEARLRDGRHPYPDDSGKEDGLEAKGTKSKQSEKNRTKRPDRDQEGADDRKESRMAESEAGKEEQDSMEESPSSVGRQEKETESSDAENTRTRKEQDSESGSEAEGESWYPTNMEELVTVDEVGEEEDFIMEPDIPELEEIVPIDQKDKICPEICPCVTTTLELDLAQDFTKEGVKTIGNGATEISLKSPKEPPSASTSCPSDMDVEMPGLNLDAERKPAECETGLSLEGSGCYEQQAKGAESSDVCLAPMLEQMSSPKPAEERAWQPGPFLDDGKVGGTPEDGAAEGRPLEEKASTPTETDLQSQACQGVSTQENSGYVEMKSLDARSPEYTEVELKQPLSLPSWEPEDVFSELSIPLGVEFVVPRTGFYCKLCGLFYTSEEMAKMSHCRSAVHYRNLQKYLSQLAEEGLKETEGAGSPRPEDSGIVPHFERKKL
What is the function of this protein?
RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH (PubMed:33188278).  Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts (By similarity).  RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles (By similarity).  RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts (By similarity).  Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity).
What are the official names of this protein?
RNA-binding protein 20, RNA-binding motif protein 20.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Note=The active form that regulates alternative splicing localizes to the nucleus (PubMed:33188278). Also localizes to cytoplasmic ribonucleoprotein granules; localization to cytoplasmic ribonucleoprotein granules plays an important regulatory role (PubMed:33188278). Subcellular localization is regulated by phosphorylation of different parts of the protein: while phosphorylation of the RS (arginine/serine-rich) region promotes nuclear localization, phosphorylation of the C-terminal disordered region promotes localization to cytoplasmic ribonucleoprotein granules (By similarity).
Protein: NAS36_CAEBR
Sequence: MRRFCRLLFLNSLLSISICKAQNPAHLVADEFKEHFNVEEKQLETVEELLLKMKKLAHSRSFAGREFGHDAVEDSKKEVAISTQQGTIDKKVSPFLFEGDIFLSRRQAVDILKALSKDKTKRLRRSFVSDKTATWKSLPIKYRFHESIDFYTISQIIAAIRFWEDSTCITFENVSDAPVGDYIEFFSGQGCYSMIGRNGGRQGISIGESCVKMGVIEHEIGHALGLWHEQSRPDALGYVSIERDFILPSYISDFLQRDDEIDTLGIPYDLGSVMHYGSTAFSVDQKSKTVVTRDSLYQQTIGQREKLSFYDVATINTAYCKEECKSEKTECEYGGYMRPSKCSECLCPDGLGGEKCEKNEDAKNAECGGILELSDEWKTIESPNYPDPGYEADQKCSWLLKAPKGKRVEIEFIEDFSFLCTSTCVDFVELKISDDLRNTGFRFCCYDKPEISFVSQIDTAIVIFRSQLSADIGFKIQVRSTESEPRTTIAPTIITTTMAPITVDTPNVWADWGEWSMCSRTCGGCGIRSRVRSCRSKKCEGRRQEFGTCNLKACPVDKHCAKLLSNNRLCNGKVCTKNDIAISSCDAPQCCPPFVNVDGMCQSDQENHHDELWLSI
What is the function of this protein?
Mtalloprotease.  Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed.
What are the official names of this protein?
Zinc metalloproteinase nas-36, Nematode astacin 36.
What are the subcellular locations of this protein?
Secreted.
Protein: SP5G_BACAC
Sequence: MEVTDVRLRRVNTEGRMRAIASITLDHEFVVHDIRVIDGNNGLFVAMPSKRTPDGEFRDIAHPINSGTRSKIQDAVLTEYHRLGELEEVEFEEAGAS
What is the function of this protein?
Essential for sporulation.  Interferes with or is a negative regulator of the pathway leading to asymmetric septation.
What are the official names of this protein?
Putative septation protein SpoVG, Stage V sporulation protein G.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: UVRC_LACP7
Sequence: MFDLDEELKKLPAKPGVYIMHNNKDEIIYVGKAISLKNRVRQYFQSSRNLSTKIQQMVSNIDHFEYIIVDSEMEALVLECNLIKEHRPKYNTMLKDDKSYPYIKVTVNEAYPRVLFARQQKKDKAKYFGPYTSLGAVKDILDLLRRLYFIRTCNRNLPKDIGLERPCLYYHIKQCKAPCQGYISEEEYRKSIDEVIEFLNGNYALVTKDLQAKMKAASENLEFEEAAGYRDLILSVEKLSQKQKASDVDGVDRDIIAFASTGDEAVAQVFFIRDGKMLGREHYHITGVANESRSSIMTNFVKQFYAGTPYIPRELLLSEPLEEEELISEWLSTKRGQKVRIHVPKKGDKERLVELAEKNASLVLQQDSDKIQREEAKTIGAVRHIADMLSLPGIYRMESFDISNTNGFESVGSMVVYENGKPKRNDYRKFKIKSVQGPDDYASMREVLTRRFSHGQKEAEELAKKNIDISHGSFTRYPDLILMDGGRGQVNIALEVMNELKLTIPVCGMVKDDNHRTRGLYFDNVEIPIDTHSEAFRLITRIQDETHRFAIEYHRSLRSKAQVHSILDDIDGVGQTRRRALMKHFASIDAIKAASMEDLMAVPSMNKLSAAKVYEFFHTSSERGTETT
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1468_SULAC
Sequence: MQRRQLEERQRKAEIEAQKDAILRTILTPEARQRLTNVKLVRPELAEAIENQLIALAQSGRIQAQITDDELKQILAQLNSQTRKDYKITIKERGWK
What are the official names of this protein?
DNA-binding protein Saci_1468.
What is the protein family that this protein belongs to?
Belongs to the PDCD5 family.
Protein: ISL2_MOUSE
Sequence: MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPSLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET
What is the function of this protein?
Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
What are the official names of this protein?
Insulin gene enhancer protein ISL-2, Islet-2.
What are the subcellular locations of this protein?
Nucleus.
Protein: HRD1_CAEEL
Sequence: MRVSAGLMIGGSCVATAATILNAFLINKQFYPSIVYLSKSNASMAVIYVQGIVLVYLMFQLLKSILFGDLRAAEAEHLSERTWHAVLETCLAFTVFRDDFSAIFVMQFIGLLFIKCFHWLADDRVDMMERSPVITLRFHLRMMTVLAALGFADSYFVSSAYFTTITRGASAQIVFGFEYAILLALVLHVTIKYLLHMHDLRNPQSWDNKAVYLLYAELFINLIRCLLYGFFAVVMLRVHTFPLFSVRPFYQSVRALHKAFLDVILSRRAINAMNSQFPVVSAEDLAAMDATCIICREEMTVDASPKRLPCSHVFHAHCLRSWFQRQQTCPTCRTDIWQGRNGAAAGGNAADAAANVADANVAGAQIGAGMPPFLPFLGHQFGFPQQPAGAGGAQPGAAQAGGQPGPFPHQIFYAPAPANRPEFMNLIPPPPLPMAGPPGMFPMMPPPPLPQVNTTQGTSSETPPVNPSYSQLSTEELRRMEGESREALLARLQAMDNIMVLLESAQMQMIQLATVTPIRPRPVVPSDESEQEAPGPSTDQVTSEEQEIPATSSAPSIFRTESPSTSSTAPSTSSPVTASSTPTTSSTRTPEAEEVRQRRLARLLGENANQ
What is the function of this protein?
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation.  Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.  Also promotes the degradation of normal but naturally short-lived proteins.  Protects cells from ER stress-induced apoptosis.  Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation.
What are the official names of this protein?
E3 ubiquitin-protein ligase hrd-1, RING-type E3 ubiquitin transferase hrd-1, Suppressor/enhancer of lin-12.
What is the protein family that this protein belongs to?
Belongs to the HRD1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MINY3_BOVIN
Sequence: MSELTKELMELVWGTNSSPGLSDTIFCRWTQGFVFSESEGSALEQFEGGPCAVIAPVQAFLLKKLLFSSEKSSWRDCPEEERKELLCHTLCDILESAGCDNSGSYCLVSWLRGKTTEETASLSGSPAQSSCQVEHSSALAVEELGFERFHALIQKRSFRSLAELRDAVLDQYSMWGNKFGVLLFLYSVLLTKGIENIKNEIEDSSEPLIDPVYGHGSQSLINLLLTGHAVSNVWDGDRECSGMKLLGIHEQAAVGFLTLMEALRYCKVGSYLKSPKFPIWIVGSETHLTVFFAKDMALVAPEAPSEQARRVFQTYDPEDNGFIPDSLLEDVMKALDLVSDPEYINLMKNKLDPEGLGIILLGPFLQEFFPDQGSSGPESFTVYHYNGLKQSNYNEKVMYVEGTAVVMGFEDPLLQTDDTPIKRCLQTKWPYIELLWTTDRSPSLN
What is the function of this protein?
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase MINDY-3, Deubiquitinating enzyme MINDY-3, Protein CARP.
What is the protein family that this protein belongs to?
Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
What are the subcellular locations of this protein?
Nucleus.