PharMolix/UniProtQA huggingface dataset:
Protein: PPIA_CRIGR
Sequence: MVNPTVFFDISADGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGDFTRHNGTGGRSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITISDCGQL
What is the function of this protein?
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).  Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity).  Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity).  Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity).  In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity).  Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity).  Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity).  Plays an important role in platelet activation and aggregation (By similarity).  Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity).  Binds heparan sulfate glycosaminoglycans (By similarity).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Nucleus. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Protein: RR8_SOLTU
Sequence: MGRDTIAEIITSIRNADMDRKRVVRIASTNITENIVQILLREGFIENVRKHRENNKYFLVLTLRHRRNRKRPYRNILNLKRISRPGLRIYSNYQRIPRILGGMGIVILSTSRGIMTDREARLEGIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PUR9_XANC5
Sequence: MASDFLPVRRALLSVSDKTGLIDLARALVARNVELLSTGGTAKAIREAGLPVKDVAELTGFPEMMDGRVKTLHPLVHGGLLGRAGVDEAVMAEHGIVPIDLLVLNLYPFESVTVKADCTLADAVENIDIGGPAMLRSAAKNFARVAVATDPAQYADLLAELEVNDGQLSAAKRFALSVAAFNRVAQYDAAISNYLSAVADSSEAVPTRSPFPAQINSNFVKVMDLRYGENPHQSGAFYRDLYPVPGTLATFQQLQGKELSYNNLADADAAWECVRQFDAPACVIVKHANPCGVAVGAGCGDAYELAYATDPTSAFGGILAFNKTLDAATAKAILDRQFVEVLIAPDYEAGALEYATRKANVRVLKIPHGNGLNNYDTKRIGSGLLMQSADNRSMSLGELSVVTQRAPNEAELGDLLFAWRVAKYVKSNAIVYAKDSRTIGVGAGQMSRVVSAKIAALKAEEAKLTVAGSVMASDAFFPFRDGIDAAAAAGIKAVIQPGGSMRDGEVIAAADEHGIAMVFTGVRHFRH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: ARY1_RABIT
Sequence: MDIEAYYQRIGYKNPRNKLDLESLTDIFQHQIRTVPYENLSIHCGESMELDLEAIFDQIVRRNRGGWCLQVNYLLYWALTTTGFETTMLGGFVCGSHTDKYSTGMIHLIVQVTINGRNYIVDAGFGRSYQMWQPVELISGKDQPQVPSIFRLREEGETWYLDQIRRQQHVPDQEFLNSELLERKTHRKLYCFTLQPRTIEEFESANTYLQISPSSPFLDKSICSLQTPEGVHCLVGLILTFRTYNYKENTDLVEFKVLTEEEVEEVLKTIFNISLGKKLVSKNGNLFFTI
What are the official names of this protein?
Arylamine N-acetyltransferase 1, Arylamide acetylase 1, Monomorphic arylamine N-acetyltransferase, MNAT, N-acetyltransferase type 1, NAT-1.
What is the protein family that this protein belongs to?
Belongs to the arylamine N-acetyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YBEY_STAA3
Sequence: MFTIDFSDHTGLVKDAWYKQIEDLLEFAKKEEHIEDDAELSVTFVDKQEIQEINRTYRDKDKVTDVISFALEEDEPEIDFSGLDIPRVLGDIIICTDVAQEQANNYGHSFERELGFLALHGFLHLLGYDHMTEADEKEMFGRQDTILNAYGLTRD
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FEX2_SCHPO
Sequence: MLLTQSYFCIMSMLGTLARLGLTALNTYPGAPFSGLLWVQFVGCVIMGFCQTESVFFPRPKHNATFLLAITTGFCGSLTTFSSWMLQMFTGMANLDPFERRGRGYSFLSVVSDFMVTMCIAMSSLIWGKQIGKTTGQWRIGKVAFAWPIPAHTHIVVRVLLLLLSICFFVGAAFYTAYTTNVTHRGIGFSLIFSPFAALTRLYLARFLNSPQYFIPYGTLCANVFATLLLSIMYMIPQITHCTPVSRSVMYGIQNGFCAVLSTLSTFSNELHTMPIKRAYIYCIISVAISFSICVIVDGATAWGHGYTEKY
What is the function of this protein?
Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
What are the official names of this protein?
Fluoride export protein 2.
What is the protein family that this protein belongs to?
Belongs to the fluoride exporter Fluc/FEX family.
Protein: KAD_BURO0
Sequence: MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKESDCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGHDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLITYYGDWAQRGEENGLKAPQYRKISGLGTVDEIRERAFDALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
Protein: PDXJ_BRUSI
Sequence: MPAKLSVNLNAIAMLRNRRDLPWPSVTGLGRAALAAGAAGLTVHPRPDQRHIRFSDLGDIRALIDDEYPQAEFNIEGFPSEAFLDLVEKHEPEQVTLVPDDPMQATSDHGWDFMSKADFLAPIVARLKGRGMRVSLFADPDSLGYERAKAIGADHVELYTGPYGATHDDPAAAARELDRLEKAARAATALGLAVNAGHDLTVDNLPALVKRIPQLAEVSIGHGLTADALMYGIPVTVSRYITALAG
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ARGB_SOLM1
Sequence: MNREHAKAHLLLEALPYIRNFYGQTVVIKYGGHAMVDEQLQESFALNVILLKYIGINPVIVHGGGPQIGRMLKLLNIESQFKQGLRVTDDATMDVVEMVLVGKVNKNIVNLINLKGGSAVGLSGKDGRLITARKLEMVLERGDAPPEIIDLGKVGEVTGINTQLITTLLAQGFIPVIAPVGVDEDGETYNINADTVAGAVAAALGAKRLVLLTDVSGVLDKDKTLISSLDIKEASQAMADGVLVGGMIPKVSCCMEAVDAGVEKAHILDGRVENCIILELFTRSGIGTEIVCKRCQA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P33MX_HUMAN
Sequence: MASRQPEVPALEASAPLGKMSLPIGIYRRAVSYDDTLEDPAPMTPPPSDMGSVPWKPVIPERKYQHLAKVEEGEASLPSPAMTLSSAIDSVDKVPVVKAKATHVIMNSLITKQTQESIQHFERQAGLRDAGYTPHKGLTTEETKYLRVAEALHKLKLQSGEVTKEERQPASAQSTPSTTPHSSPKQRPRGWFTSGSSTALPGPNPSTMDSGSGDKDRNLSDKWSLFGPRSLQKYDSGSFATQAYRGAQKPSPLELIRAQANRMAEDPAALKPPKMDIPVMEGKKQPPRAHNLKPRDLNVLTPTGF
What is the function of this protein?
Potential NADPH-dependent oxidoreductase.  May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.
What are the official names of this protein?
Putative monooxygenase p33MONOX, Brain-derived rescue factor p60MONOX, Flavin monooxygenase motif-containing protein of 33 kDa.
What is the protein family that this protein belongs to?
Belongs to the P33MONOX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADJ_YERPE
Sequence: MGASATNSVTHPAFTLNVRPDNIGIITIDVVGDKVNTLKAEFADQIATILQQAHALPKLQGLVIVSGKPDSFIAGADITMIAACRTAHDARVLAQKGQSILAQIAAFPVPVVAAIHGACLGGGLELALACHSRICSLDDKTVLGLPEVQLGLLPGSGGTQRLPRLVGVSKALDMILTGKQIRPRQALKMGLVDDVVPRDILLDVAIQRAKAGWLNRRALPWQERLLSGPLGKALLFRIVRKKTLAKTRGHYPAAERIIDVVRKGLDQGGPSGYEAEARAFGELAMSPQSAALRSLFFATTSLKKETGSAATARAIHRVGVLGGGLMGGGIANVTATRAGLPVRIKDINPQGINQALKYTWDALGKRVRSKRMRPTEQQRQMMLISGSTDYRGFERVDIVVEAVFEDLSLKQQMVADIERFGAAHTIFASNTSSLPISQIAALAQRPEQVIGLHYFSPVDKMPLVEVIPHEKTSEETIATTVALARKQGKTAIVVADRAGFYVNRILAPYINEAARCLLDGEPIESVDNALVDFGFPVGPMMLLDEVGIDVATKIMPILVEQLGPRFAAPPSFDVILKDGRKGRKNGRGFYLYSNPTKNSSPTKNGNSPAKRNSFKWRKNKVKPVDASIYTLLGVTPKAHLGAGVITQRCTMLMLNEAVRCLDESIIRNPRDGDIGAVFGIGFPPFLGGPFRYLDSLGADKVVQALRLLVQQYGERFEPCQRLVTMAEQQQQFYPVDANIDEVTDVAS
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_PSEMY
Sequence: MKTFTAKPETVKRDWFVVDAAGQTLGRLATEIASRLRGKHKPEYTPHVDTGDYIVVINAEQVRVTGAKASDKKYYSHSGFPGGIKEINFEKLIARAPERVIETAVKGMLPKNPLGRDMYRKLKVYKGAAHPHTAQQPQELKI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: ACO3M_ARATH
Sequence: MYLTASSSASSSIIRAASSRSSSLFSFRSVLSPSVSSTSPSSLLARRSFGTISPAFRRWSHSFHSKPSPFRFTSQIRAVSPVLDRLQRTFSSMASEHPFKGIFTTLPKPGGGEFGKFYSLPALNDPRVDKLPYSIRILLESAIRNCDNFQVTKEDVEKIIDWEKTSPKQVEIPFKPARVLLQDFTGVPAVVDLACMRDAMNKLGSDSNKINPLVPVDLVIDHSVQVDVARSENAVQANMELEFQRNKERFAFLKWGSTAFQNMLVVPPGSGIVHQVNLEYLGRVVFNTKGLLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLAGKMRNGVTATDLVLTVTQMLRKHGVVGKFVEFYGNGMSGLSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRSDETVAMIEAYLRANNMFVDYNEPQQDRVYSSYLELNLDDVEPCISGPKRPHDRVTLKEMKADWHSCLDSKVGFKGFAIPKEAQEKVVNFSFDGQPAELKHGSVVIAAITSCTNTSNPSVMLGAGLVAKKACDLGLQVKPWIKTSLAPGSGVVTKYLLKSGLQEYLNEQGFNIVGYGCTTCIGNSGEINESVGAAITENDIVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTVNIDFETEPIGKGKNGKDVFLRDIWPTTEEIAEVVQSSVLPDMFRATYESITKGNPMWNKLSVPENTLYSWDPNSTYIHEPPYFKDMTMDPPGPHNVKDAYCLLNFGDSITTDHISPAGNIQKDSPAAKFLMERGVDRKDFNSYGSRRGNDEIMARGTFANIRIVNKLMNGEVGPKTVHIPSGEKLSVFDAAMRYKSSGEDTIILAGAEYGSGSSRDWAAKGPMLQGVKAVIAKSFERIHRSNLVGMGIIPLCFKSGEDADTLGLTGHERYTIHLPTDISEIRPGQDVTVTTDNGKSFTCTVRFDTEVELAYFNHGGILPYVIRNLSKQ
What is the function of this protein?
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.  Contributes to oxidative stress tolerance (PubMed:17013749).  Modulates cytosolic citrate metabolism during lipid mobilization.  Required during seedling growth (PubMed:25061985).
What are the official names of this protein?
Aconitate hydratase 3, mitochondrial, Aconitase 3, mACO1, Citrate hydro-lyase 3.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Note=Cytosolic localization in 3-day-old seedlings, but mitochondrial in 10-day-old plantlets.
Protein: ARLY_MYCSK
Sequence: MSTNEGSLWGGRFADGPADALAALSKSTHFDWVLAPYDIAASKAHARVLFSAGLLTEDQRDGLLAGLDSLASDVADGSFAPLVTDEDVHGALERGLIDRVGAELGGRLRAGRSRNDQVATLFRAWLRDAIRRVADGVLGVVSALATQAAAHPTAIMPGKTHLQSAQPVLLAHHLLAHAHPLLRDVDRLADFDKRAAVSPYGAGALAGSSLGLDPDAIAAELGFDSAADNSIDATAARDFAAEAAFVLAMIGVDLSRLAEDIILWSTTEFGYVTLHDAWSTGSSIMPQKKNPDIAELARGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFDSVAQLELLLPAVAGLVSTLSFDVDRMAELAPLGYTLATDVAEWLVRRGVPFRVAHEAAGAAVRAAEARGVGLEDLEDAELTGIHPELTGDVREVLTIEGSVNSRDARGGTAPVQVAKQLNVVRDTADRLRLRLRT
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RN182_AILME
Sequence: MASQSPDEAAEAQVSDELECKICYNRYNLKQRKPKVLECCHRVCAKCLYKIIDFGDSPQGVIVCPFCRFETCLPDEEVSSLPDDSNILVNLTCGGKGKKGLPENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLSSTPVVEFYRPASFDSVTTVSHNWTVWKCTSLLFQTSIRVLVWLLGLLYFSSLPLGIYLLVSKKVTLGVVFVSLVPSSLVILMVYGFCQCVCHEFLDCVAPSS
What is the function of this protein?
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.  Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA.
What are the official names of this protein?
E3 ubiquitin-protein ligase RNF182, RING finger protein 182, RING-type E3 ubiquitin transferase RNF182.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cytoplasm.
Protein: PLSY_SHIDS
Sequence: MSAIAPGMILIAYLCGSISSAILVCRLCGLPDPRTSGSGNPGATNVLRIGGKGAAVAVLIFDVLKGMLPVWGAYELGVSPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKFKRKREKDPE
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRMD_COXB2
Sequence: MKLIIGVITLFPQMFDALKSGVIGRALKQDRLTLSFWNPRDYATDPHRTVDDRPYGGGPGMVMKFEPLALALKAAKAQLGENTKVIHLTPQGKLLTQAIVREKIHASPLILLAGRYEGIDERLIEAEVDEEWSIGDYILSGGELPAMVLIDAMTRLLPGVLGHKDSASQDSFTAGLLDYSHYTRPEKIADRPVPSVLLSGDHEAISRWRLKQSLGRTWQRRQDLIKRRSLSENEQRLLDEFFEESS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_HELPS
Sequence: MHSDELLVEILVEELPAQALLNEYKEMPKKLHALFNKRALEVGKIEIFYTPRRLCLLVKDFPLLTQETKEEFFGPPVKIACNHQDKTQGLNELGLGFYQKLGLKDHQHFQTAFKNNNEVLYHAKIHAKEPTKDLIMPIVLEFLEGLNFGKSMRWGNVEKSFIRPIHNICVLFNGENFNDIEVKEYGFKTKQATKAHRQEGFDFIQVDSPKAYFEVLEKNHVILDPKKRKAKILQEIKELETKHRIIVEIDRDLLDEVVAITEYPSALLGEFDKAFLKLPNEIIITSMKENQRYFAAFNQKSQESPTLHNGFIVVSNAISKDKQKIIAGNQKVLKARLSDAVFFYENDLKKPLDNAPLESVVFVQGLGTLKDKMEREAIIAQYLTQKYASSLNMPLEKALELVGRAVRIAKADLLSEVVYEFSELQGIMGYYYALKQNENELVALSVKEQYLPASENAPLPSSVFSAIVALSLKLDSLFSLFSVGKIPSGSKDPFALRRLSFGLLKIVVHYGLEFDLKADLKNLFEKVGVYQSFDLEVLEKFLLERFNNLIDCNPSIIRSVLNTNERGIVKIIQKVKALKRFLDDPKNAQKKELLFSAFKRLANINKDRNPNESSEFFISLFKESQEHALFEAFNAIKTSTFESLDSKIEAYFGLHAPLEEYFKSVLVMDKDIEIQKNRKNFLWGVYQSFLEIGDIKEIAI
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GMT1_EMENI
Sequence: MTDNRKPEDYTIEMDKLGQNKNYQAPPPPPQPRSSTASSISNNAALSVLAYCGSSILMTVMNKYVLSSDFNLNFFLLCVQSLVCIIAIQLCKACGLITYRDFNLDEARKWFPITLLLIGMIYTGSKALQFLSIPVYTIFKNLTIILIAYGEVLWFGGSVTNLTLFSFGLMVFSSIIAAWADIKHAIESSGDATSKVSTLNAGYIWMLINCLCTSSYVLGMRKRIKLTNFKDFDTMFYNNLLSIPVLIVCSGILEDWSPANVARNFPSADRNGIMFAMILSGLSTVFISYTSAWCVRVTSSTTYSMVGALNKLPIALSGLIFFDAPVTFPSVSAIMVGFVSGIVYAVAKIKQNAKPKVGILPTTNPVSASSQSMRDSLRS
What is the function of this protein?
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
What are the official names of this protein?
GDP-mannose transporter 1, GMT 1.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family. SLC35D subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: DGAT2_BOVIN
Sequence: MKTLIAAYSGVLRGTGSSILSALQDLFSVTWLNRAKVEKQLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTSRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPRLERPTQQDIDLYHAMYVQALVKLFDQHKTKFGLPETEVLEVN
What is the function of this protein?
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.  Required for synthesis and storage of intracellular triglycerides (By similarity).  Probably plays a central role in cytosolic lipid accumulation.  In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity).  Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity).  Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity).
What are the official names of this protein?
Diacylglycerol O-acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diglyceride acyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet. Cytoplasm, perinuclear region.
Protein: COBS_AZOC5
Sequence: MRHSRILADVGAALRFYSRIPVPAGAAEDAFAPPDLKRIAYAVPLAGAAIGLAGAAILIGAHALGLPNLVAAILAVLTCVLLTGALHEDGLADTADGFGGGASRLRRLEIMRDSRIGSYGACALVFSLLLRVALLDGLLALSPTRAALALIAAASLSRAAGMLLLEFLPPARADGASAAAGQPGADAAVRSALVGALLATLLIVPSTGVGATLMAIGLSVLALFAMTRLSNRLIGGQTGDVAGAVQQLCEIAFLMGVLIYARPH
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SK1_RHOPR
Sequence: QFNEYGHMRF
What is the function of this protein?
Myotropic peptide.
What are the official names of this protein?
Sulfakinin-1, Rhopr-SK-1.
What is the protein family that this protein belongs to?
Belongs to the gastrin/cholecystokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: CTAA_EHRRW
Sequence: MNIINNSENVCTGVKIWLCICCIGILVMVFIGGITRLTHSGLSITEWNPVIGIFPPVTEKMWIAEKIKYMATPEYKYITSNITLTEFKKLYLIEYFHRLLGRIVGLVFLIPFLYFMYKQKLSKNLIHRFILIAFLILVQGVMGWYMVKSGLIDRPHVSHYRLAMHLLLALAIFYLLWKHFLLSVVHQIKCNIKVTNTSVFYIIISLITIQITCGALVAGLNAGLLSKDIPFLSDKVGLNDLLFIKPWWHNIYNNPITVQFIHEVIALLILIIVVITLLVLKVRIFPMYLLLALLLIQLTLGILTFIYNVPIILASLHQVTAFILFASSIYLLHYVKLLQIQYVKNKI
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GA45A_CRIGR
Sequence: MTLEEFSAAEQKTERMDTVGDALEEVLSKARSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLESDAGPAESGGASQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER
What is the function of this protein?
Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.  In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity).
What are the official names of this protein?
Growth arrest and DNA damage-inducible protein GADD45 alpha, DNA damage-inducible transcript 1 protein, DDIT-1.
What is the protein family that this protein belongs to?
Belongs to the GADD45 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: C4D21_DROME
Sequence: MWILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPENFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLSTGNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTTETAMGVQVNAQNEPNFPYTKALKSVVYIESKRLASVSMRYNWLFPLAAPLVYRRLQKDIAIMQDFTDKVIRERRAILERARADGTYKPLIMGDDDIGGKAKMTLLDILLQATIDNKPLSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQTKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEYFPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELLPLGADLKATYTFILSSSTGNNVGLKPRTRVK
What is the function of this protein?
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
What are the official names of this protein?
Probable cytochrome P450 4d21, CYPIVD21.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.