PharMolix/UniProtQA huggingface dataset:
Protein: RL36_STRPM
Sequence: MKVRPSVKPICEYCKVIRRNGRVMVICPTNPKHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: ASTD_BURL3
Sequence: MTELFIDGAWVAGSGPVFASRNPGTDEIAWQGESASAADVDRAVASARRAFAGWSALDFESRCAIVKRFAALLNERKEAIAAAIGRETGKPLWEARTEVASMAAKVGISIQAYQERTGEKRQDMADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNAVVFKPSELAPGVARATVEVWKEAGLPDGVLNLVQGEKDTGIALANHRQIDGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVIGEVEDIDAAVHHTIQSAFLSAGQRCTCARRIFVPQGAFGDRFLARLTDVTSKITADVFDADPQPFMGAVISARAAAKLVDAQSRLIEQGAKPIIAMTQRDPRLGFVNAAIVDVTGVANLPDEEHFGPLAQIVRYATFDDAIERANDTAFGLSAGLLADDAKTWEHFRRTIRAGIVNWNRPTNGASSAAPFGGTGRSGNHRPSAYYAADYCAYPMASVESTQLTLPASLSPGLHF
What is the function of this protein?
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
What are the official names of this protein?
N-succinylglutamate 5-semialdehyde dehydrogenase, Succinylglutamic semialdehyde dehydrogenase, SGSD.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. AstD subfamily.
Protein: PETG_CRUWA
Sequence: MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDF
What is the function of this protein?
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  PetG is required for either the stability or assembly of the cytochrome b6-f complex.
What are the official names of this protein?
Cytochrome b6-f complex subunit 5, Cytochrome b6-f complex subunit PetG, Cytochrome b6-f complex subunit V.
What is the protein family that this protein belongs to?
Belongs to the PetG family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DCSA_DICDI
Sequence: MDRNEGGDFPINTPNNINSSGGSYNNSMNNSSNNIGRDIGNNQSSRNLKPKPSQSNLKWIARDLKKKSVRKDSERKLKSSGVLKKKNTVMDFGEDDGGSGDDGNITEGLPISEGMDDLPSSSNSRGGSGNDEQKKQFPKEMNSPSSEYGTTSGGQRFDTLVDPDISLAEMEEKMRQHKVYQEQQQQQQQQQQQQKQKDKELSSQKKKPSSMQLSKKKHVAKEDSETLETIIGEEKKEVVFEVKPYFSHAILQATMAVFLIWNIFYFAYRAGWTMNRTDYITFSYSILFIIVEFISFLGSALHLNNFTNPCTFVLVVTLEQILAKRRKKHPTVMMYVCTYKEPPSIVSRTFRTAISMDYPSENLWIGLLDDSVNYRESRGWAHLQSVEKNFLYVLLQKAVYSVHNIRPPVTSQHEDPHGILNETSSKIESSTKEVIEAEVQWFIEYFLLNSWFGVGQEIPRDADDAERALIAKLRDDNFSPYRTFTKSESEKISNFTIDSLQSLWHGSAFFRPLIRSILLKKDYVRNFVSELNNQHRLRFLNTEALAMAQYQVLMMGRQELPWDEISSGNVRIDFDTCDGPIVSPKCTYLRRRKPPIPHNKAGNINNALFNESTKADYEFLGLLDADQQPHPDFLKRVLPYFYSDEGQDLAFVQTPQFFSNIYPVDDPLGHRNMEFYGPVMEGRSANNACPFVGTNAIFRRQPLYDIGGIMYNSVTEDMYTGMKLQVSGYKSWYHNEVLVVGTAPVDLKETLEQRKRWAQGAVEIFSLTPWGYIRGKLGWRKMLYNLDSCIYPFLSPTAFFYGASPLIMSIWTVPIVVKDPIIFILVGMIPVMVLPRVIQYMILRAKRPYEAGKSGPSLWVEATDLWRAEQTFFGFAGTYISSWREGSASIVKLLKARKISRHKLAMWNWKRDFVKKPVVCEVFRQTKLVNENDNAQESSGKHKAEQSFRTSNKESDTIKNSRLFLPNIILFVVNILAMMSAVLRFNCFQNDMWLLVVVAGFSFSTLWHLWSFIPMALRQSEKQWPYASSYHAHNIVLFLVLGFLVLLFVDVKVCIPRVG
What is the function of this protein?
Catalytic subunit of cellulose synthase.  It incorporates glucose from uridine 5'-diphosphate glucose (UDP-alpha-D-glucose) to cellulose (a (1->4)-beta-D-glucan), which is produced as an extracellular component for mechanical and chemical protection at the onset of the stalk formation, when the cells exhibit multicellular behavior during culmination.
What are the official names of this protein?
Cellulose synthase catalytic subunit A [UDP-forming], DcsA.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RS8_ANAD2
Sequence: MSFTDPIGDMLTRIRNASSARHEKVLVPASRLKVRIAEVLREEGFIKDFVLHEDGVQGAITIVLKYSADREPAISDIKRVSKPGLRRYVATDSIPRVLNGMGVAILSTSKGVMVDREARKQKVGGELICTVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: DSCR6_XENLA
Sequence: MDSSQYMLKATLTQMCLCSRGVRNVHSEHPQQQDSSLTLWRPWLLGAGDRELDGQQRRSGEADGVPTNTGPKGALGFQHPVRLYMPKSKTSEYLQHMGRKVLASFPVQATIHFYNDDSDSEEEDEEEEMEFYNYYQNCAANGVDSSRGSSDNYSVQGGPKRNIGSHAGSA
What is the function of this protein?
Acts as a transcriptional corepressor.  Negative regulator of the transcriptional activity of tbx1 that plays a key role in pharyngeal development.  Plays a role in the formation of the anteroposterior (AP) axis during embryonic development; required to establish the posterolateral border of the pre-placodal ectoderm (PPE) acting downstream of the retinoic acid receptor (RAR) signaling.
What are the official names of this protein?
Protein ripply3, XRipply3, Down syndrome critical region protein 6 homolog.
What is the protein family that this protein belongs to?
Belongs to the ripply family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CNBL6_ARATH
Sequence: MMMQCLDGLKHLALILLTCCDADPPKVRQNPKDVARGTVFTVNEIEALYELFKSISKNGLIDKEQFQLVLFKMNTTRSLFADRVFDLFDTKNTGILDFEAFARSLSVFHPNAKFEDKIEFSFKLYDLNQQGYIKRQEVKQMVVRTLAESGMNLSDHVIESIIDKTFEEADTKLDGKIDKEEWRSLVLRHPSLLQNMSLQHLKDVTKTFPNFVFHTIVTDTPSELDG
What is the function of this protein?
Acts as a calcium sensor.  CBL proteins interact with CIPK serine-threonine protein kinases.  Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.
What are the official names of this protein?
Calcineurin B-like protein 6, SOS3-like calcium-binding protein 2.
What is the protein family that this protein belongs to?
Belongs to the calcineurin regulatory subunit family.
What are the subcellular locations of this protein?
Vacuole membrane; Lipid-anchor. Note=Tonoplast localization abolished by 2-bromopalmitate (2-BP) treatment.
Protein: PTBP3_MOUSE
Sequence: MNSSTSAGVYANGNDNKKFKGDRPPCSPSRVLHLRKIPCDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMINYYTPVTPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGNLSLPGATANEGTLLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAQYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIMSSPYAGAAGFAPAIAFPQAAGLSVPAVPGALGPLTLTSSAVSGRMAIPGASGMPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI
What is the function of this protein?
RNA-binding protein that mediates pre-mRNA alternative splicing regulation.  Plays a role in the regulation of cell proliferation, differentiation and migration.  Positive regulator of EPO-dependent erythropoiesis.  Participates in cell differentiation regulation by repressing tissue-specific exons.  Promotes Fas exon 6 skipping.  Binds RNA, preferentially to both poly(G) and poly(U) (By similarity).
What are the official names of this protein?
Polypyrimidine tract-binding protein 3, Regulator of differentiation 1, Rod1.
Protein: THII_SHEB5
Sequence: MKFIVKLYPEIMMKSKPVRMRFTKMLETNIRNVLKKVDEDAKVQRQWDRIMVMVPKDKPELAQAFGERLACIPGIAHVVQVDEYSFESVDDIYQQVLPVYRDQLAGKTFCVRVKRTGDHDFNSIEVERYVGGGLNQFTDALGVRLKNPDITVNLEIERDNLYMVTKRIEGLGGFPMATQEDVLSLISGGFDSGVSSYQFIKKGARTHYCFFNLGGAQHEIGVKQVAYHLWKTYGESHKVKFISVPFEPVVAEILERIDNGQMGVVLKRMMMRTAARIADRMGIQALVTGESLGQVSSQTLTNLNVIDRCTELLILRPLIAMDKQDIINESRKIGTEDFAKSMPEYCGVISQKPTVKAVLAKVEAEEKKFSEDLIDQIIAQSVTIDIREIAEQMDTRITETETVASIDTNQVVIDIRAPEEEESKPLQIEGIEIKRIPFFKLATQFADLDKQKTYLLYCERGVMSKLQALYLIEQGYTNVKVYRP
What is the function of this protein?
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor.  Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate.  This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway.  The sulfur is donated as persulfide by IscS.
What are the official names of this protein?
tRNA sulfurtransferase, Sulfur carrier protein ThiS sulfurtransferase, Thiamine biosynthesis protein ThiI, tRNA 4-thiouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSE_HELPJ
Sequence: MLDLSYSLERVLQEDPAARNKWEVLLLYPGIHALLCYRLAHALHKRRFYFIARALSQLARFITGIEIHPGAKIGRGLFIDHGMGVVIGETTEIGDDVTIYHGVTLGGTGKFKGKRHPTLGNRVVVGAGAKVLGAICVGDDVRIGANAVVLSDLPTGSTAVGAKAKTITKDR
What are the official names of this protein?
Serine acetyltransferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS16_ALKOO
Sequence: MAVKIRLKRMGAHKKPFYRIVVADARSPRDGRFIEEIGYYNPVSEPKEIKINNEKAEKWLKNGAQPTDTVKDLFKKNGIIE
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: FADH_PSEAE
Sequence: MSGNRGVVYLGPGKVEVQNIPYPKMQDPQGRQIDHGVILRVVSTNICGSDQHMVRGRTTAPEGLVLGHEITGEVVEIGRGVETMKIGDLVSVPFNVACGHCRTCKEQHTGVCLTVNPARAGGAYGYVDMGGWVGGQAEYVLVPYADFNLLKLPNREAAMEKIRDLTCLSDILPTGYHGAVTAGVGPGSTVYIAGAGPVGLAAAASARLLGAAVVIVGDVNPTRLAHAKKQGFEIADLSKDTPLHEQIAALLGEPEVDCAVDAVGFEARGHGHSGSQQEAPATVLNSLMGITRVAGKIGIPGLYVTEDPGAVDAAAKHGALSIRFGLGWAKSHSFHTGQTPVMKYNRQLMQAIMWDRIKIADIVGVEVITLDDAPKGYGEFDAGVPKKFVIDPHNLFRAA
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of formaldehyde and acetaldehyde.
What are the official names of this protein?
Glutathione-independent formaldehyde dehydrogenase, FALDH, FDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: Y1753_AERPE
Sequence: MASPNRLIVAVTGLPGSGKSVVARIVAEELGLEVKVMGDVVREETVRRGLEPTPENVERVARMLREELGRAAVAKLLAERLEPGRSYVLDGLRSVEEAEVLARAGWRVFIIGVYAPRKQRLERLMRRRRSGETLWEVLELRDASNIELGVGEALALSDYLIVNTGSLEDLEFEARRAARVAICGGDP
What are the official names of this protein?
UPF0200 protein APE_1753.1.
What is the protein family that this protein belongs to?
Belongs to the UPF0200 family.
Protein: ZNF48_MOUSE
Sequence: MEASPGDEFEHSPQERDGPEIKEEEQLAPTLQVGNTSLKPDGIQCWDDLWDRREGLGKRQPRDPVPRILGEPRWGQGSNDRAAVCGECGKSFRQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHTGEKAYRVRPPAPGPPKMPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQRTHRGDQLPRPVVPRRQPSPAAPAAPHRPKAQDKPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGQRPHACPECNRSFSLSSTLLRHRLTHVEPQDFSLAAYPVVPLIPSPPPPPLGTSPSLTPRSPSHSSDGPFGLPGLEPEPGGPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSARVKHLRTHQGERTRPPPPPSTLLRPHNPPGSVPIVPQSRVQGRPSGPSQLHVCGFCGKEFPRSSDLVKHRRTHTGEKPYKCAECGKGFGDSSARIKHQRGHLALKPFGVGDGPPRPLKEESPAGLE
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 48, Zinc finger protein 553.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TOP3_PASMU
Sequence: MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGADDYVTWCIGHLLEQAEPDAYDPKFKQWRLEHLPIIPEKWQLIPRKDVHKQLTIVEKLIHQADILINAGDPDREGQLLVDEVFSYANLSVDKLNQIQRCLISDLNPSAVEKAVNKLQSNRNFIPLATSALARARADWLYGINMTRAYTLRGRQAGYQGVLSVGRVQTPVLGLIVRRDLEIENFKPQDFFEVLAHIQAETPEKITALSAQEKANIPQFKALWQPSKACEDYQDEEGRVLSLGLVENVVKRIAQQPAEVVEYVDKREHESAPLPYSLSALQIDAAKRYGLSAQEVLDICQRLYETHRLITYPRSDCRYLPEEHFGERTKVFQAISRHISDYQPLPDILNPEQKNRCWNDKKVEAHHAIIPTAKNTPVNLNQREWQIYHLIARQYLMQFCPDAEYRKSKITLNIAGGTFIAQARNLQVAGWKQLLGKEDSDEQQEPLLPVVKKGQILFCEKGEIVSKKTQPPKPFTDATLLSAMTGIARFVQDKELKKILRETDGLGTEATRAGIIELLFKRGFLYKKGRNIHSTETGRILIQALPDVATQPDMTAHWESQLTSISQKEMSYQQFMSTLTNFLPELMRYVNFAALRQLSQVEKPQSFSKKMSAKSKKRPT
What is the function of this protein?
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex.  Introduces a single-strand break via transesterification at a target site in duplex DNA.  The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.  The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils.  Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
What are the official names of this protein?
DNA topoisomerase 3, DNA topoisomerase III.
What is the protein family that this protein belongs to?
Belongs to the type IA topoisomerase family.
Protein: RS5_METS5
Sequence: MAEEVPVSNVEEWKPRTKIGQLVKEGKITSIKELYARNMSIAEPEIIDVLLPNMKYEVIDIGMVQKQTDAGELSRYKVLVVMGNYDGYVSIGVGKSKQLRVAIQKAIRDAKMHVIPVRRGCGSWECTCGESHSLPFLVSGKSGSAEVVLRPAPKGTGLVAGGVLKTLLTYAGIKDVWSFSRGETRTTDNFIMAGYRALYNTYKFVTPVDWARRR
What is the function of this protein?
With S4 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: MUS81_NEUCR
Sequence: MAGDTGANPLFLGWVKEWWDTAREHNTKGAPTYKKAYNSLKACPLTFQHPSELQVLNGFGPTISQRLTDRLKQYCEENGLPMPKHPKRKRTLELESALAAAGAVQDEQPPPPKRARTARPYVPKLNSGAYALLMALSELGPKEFMDKTTLIAKAQPYSEHSFTVPTMANKSYTAWDSMKTLEQKELVWLRGLPSKRYSLTDEGWEVVKRMKEAQNLVDGVAGSANTSRNAIASGSGTSNPNRSENVNPNRQDSGVKRESRYTPLDLKPFVTTTATPERPLQPKPHTANSEYSIIIDSDDEDPKYDEEDRKPIIRDTTNRDYIDLVADGDSVPDESNLPHFTPIRLAPGSFTVELVLDTREVQAKNNRDHIQEELSKLGVRPVMRSLELGDVLWIAKCKQPGWLNRLGAEGDEVVLDYIVERKRLDDLIGSIKDGRFREQKYRLKRSGMKNVVYIIENYNIDMDIRRQYQDAMDTAMASIQVVNGYFLKKTDTIAESIRYLAAVTYMLKEIYESKPLFVIPTQVLTAKNYLPLVKHLREKEPSRGYYISYPAFASLVSKSEMMTLKDVFIKMLMCIRRLSGEKAIEIQKVWKTPYQLVKAFEACGSDENGKKKQKVLVMSMLSHLVDRRNVDKGLSERIADVWGFL
What is the function of this protein?
Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick.  Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions.  May be required in mitosis for the processing of stalled or collapsed replication fork intermediates.  May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
What are the official names of this protein?
Crossover junction endonuclease mus-81.
What is the protein family that this protein belongs to?
Belongs to the XPF family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TRPR_ECOLC
Sequence: MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: E311_ADE03
Sequence: MILFQSNTTTSYAYTNIQPKYAMQLEITILIVIGILILSVILYFIFCRQIPNVHRNSKRRPIYSPMISRPHMALNEI
What are the official names of this protein?
Early E3 9.0 kDa glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the adenoviridae E3A-1 family.
What are the subcellular locations of this protein?
Host nucleus membrane; Single-pass membrane protein.
Protein: MPZL2_MOUSE
Sequence: MYGKSPALVLPLLLSLQLTALCPTEAVEIYTSGALEAVNGTDVRLKCTFSSFAPVGDALTVTWNFRPRDGGREQFVFYYHMDPFRPMSGRFKDRVVWDGNPERYDVSILLWKLQFDDNGTYTCQVKNPPDVDGLVGTIRLSVVHTVPFSEIYFLAVAIGSACALMIIVVIVVVLFQHFRKKRWADRADKAEGTKSKEEEKLNQGNKVSVFVEDTD
What is the function of this protein?
Mediates homophilic cell-cell adhesion.
What are the official names of this protein?
Myelin protein zero-like protein 2, Epithelial V-like antigen 1.
What is the protein family that this protein belongs to?
Belongs to the myelin P0 protein family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: SLX1_ASHGO
Sequence: MGDDIGTAGVPAFYCCYLLRSIPKRLSYYIGSTPNPVRRLRQHNGLLTKGGAYRTKRQGTRPWELAASVSGFPSKIAALQFEHAWQHPYQTRFIKSEDRIVKKKGGGRSIHQRLAVLKLLLHHPFFKVMSLVVHLFSEDIQRVWFLDKYKLEAPFIHVEVDEDALSEPTGEDEESVIEHAKKNLRLVELFYGRSLKEDSECLEEYRRRLQNGAMRCAICEKIVDYVKDSDSFSSEKELVAFCYNSVCDYFSCLSCLYNVFASDEELRTGEIPLIPTSGQCPNCNIELSWARIVRYSMFLSA
What is the function of this protein?
Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination.  Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
What are the official names of this protein?
Structure-specific endonuclease subunit SLX1.
What is the protein family that this protein belongs to?
Belongs to the SLX1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FTSZ_BORBU
Sequence: MKDYNMIDSHTRRFDSTTNPTILKVIGAGGGGSNAVNRMIEYGVRDVEFIVANTDLQALQTSIAPIKIALGAKVTAGLGAGGKPEIGQAAAEEDIDVIRNHLSGADMVFITAGMGGGTGTGAAPVIAQVAKELGILTVGVVTKPFKFEGPKKLRLAEQGINNLRKSVDTLIIIPNQKLLTVVDKRTTIKDAFKRADDVLRMGVQGIAGLIIEHGEVNIDFADVKSIMQGQGDALMGIGYGKGENRAVDAATSAISNPLLEEVRIEGSKGLLVNVTGGDDFSLLELEEIMGIITVSVDDEATVIYGHAINSNLEDEIYVTVVATGFASKKQKEISSTPENNTLSSKEFDTLMSGNQNAPSGSYEQQDSSFAAKSKNVNYFDDDIDVPTFLRNLNKKSSDD
What is the function of this protein?
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.  The regulation of the ring assembly controls the timing and the location of cell division.  One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells.  Binds GTP and shows GTPase activity.
What are the official names of this protein?
Cell division protein FtsZ.
What is the protein family that this protein belongs to?
Belongs to the FtsZ family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane.
Protein: HEM1_BACCR
Sequence: MHILVVSVNYRTAPVEFREKLTFQAAEIERAMTTLQNQKSVLENVIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLEIEEVAPYLTIFEQDGAIDHLFRVTCGLDSMVVGETQILGQIKDSFLEAQQVKATGTIFNELFKQVITLAKRAHSETTIGESAMSVSYAAVELGKKIFGELTDCHVLILGAGKMGELALQNLYGSGARKVTVMNRTLSKAEVMAEKYMGHAKSLSELQCALLEADILISSTGASEYVITKEMMTKVEKMRSGRPLFMVDIAVPRDIDPAIDELEGSFLYDIDDLQGVVEANRAERLKEAEKIQFMIEEEIVLFKTWLSTLGVVPLISALRDKALAIQSETMVSLERKIPNLSDREKKVISKHTKSIINQLLKDPILVAKEIAAEEGASEKLALFAKIFDLETEEVESRAEEVEHKRVWTPSVPSL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: DNA2_SCHPO
Sequence: MFNDQSKTTSSVKGICATTDNNHGNLKKTNSTPFRKNYLLNGRTKLKLENFAYNASTEISSPKISEKKHSSLPIKRKNTFNESSTSFSPFTKAHKEITDDLKPDKSFTRKSDLNSQDMPVCFQETSKDLCRSSSTQHLLDHQTTDSTIIDMKPVSTNSKSDVFTLYTDETVLLRRCASDNKPLINNNLSSSNVSENQSRSFGSYDEVKNQGNNLHKVPSLVSIIRNARSSEQSRIAANSSCLLKGSDTEIDEDDFALEAEDLAALDSLERQYSQLPNSTVTASAKDIEKTAKVNHVGGDLQSYCSATKASDATINEEPVNLALDKACNSLPDINSDFIDDWDDSCDGCTPGELCEFSSEYTVLEVHEDFIFHEGNHFRQLKLILEANDILHQLFLRGDWTETSIFVGDSIRVEATFDKDNTAIVDNDKGLIIIHPKILMSATAVASSFPCLRKAVISDRVGIYGPPTKAMVTGNILHDFFQHALYRGIDALENVDINLETSIKTYISDIYFADLSLDEIREELDARLPLLKSIVERYLISKKNDNNNESIHISRLLDIEESIWSPRFGLKGNIDATVEVVLTEKPESSSTLTLPLELKTGRYVDNISHFAQSLLYTLLISDRYGINTNQALLCYLENSTIKNLVASNSQLRGLIMTRNSLAQHNFRRSLPEMISNRKICDHCSLVSECLFFQKMSDKGVANSNGLTESWNEWMREVKDEDLEFYKKWEKLLNQEERLLLLKRGDVLTFDTEELEAYGKTLYPLYITKEDIVCLEIDDRVFHYKFAFLNDNGYPRNFLHSGFSVGERVFISDEHGHWSLAKGHIVHIQDSCIEVRTRHRLHIPWLKMPNFDFKKNQVFFGNYEDSKLSFIGSNHTRYRIDKDEFSSGIASIRGTLMSSVLPDAPLIIRDMIIRLKPPKFCNSALIDPEFLKCLNEDQITALKKCHAAEHYSLILGMPGTGKTTTISSLIRSLLAKKKKILLTSFTHLAVDNILIKLKGCDSTIVRLGSPHKIHPLVKEFCLTEGTTFDDLASLKHFYEDPQIVACSSLGVYHSIFNKRKFDYCIIDEASQIPLPICLGPLQLAEKFVLVGDHYQLPPLVKNSRTSKDGLSLSLFKLLSEKHPEAVTTLRLQYRMNEDINSLSSELIYGGNLVCGSKTISQKKLILPKAHLSDGLPDSSSSLHWVNKLINPSHSVIFFNTDDILGVESKTNNILENHTEAFLIEQAVSSFLERGVKQSSIGIISIYKSQVELLSKNLKSFTEIEINTVDRYQGRDKDIILISFVRSNSKNLVGELLRDWHRLNVALSRAKVKCIMFGSLSTLSSSNIVSHLLKLLEKNKWIFTLNENDIATKFDENSSPIKDCSQVATTNNAKVIIRKNQRFFNSDNLCEKAILPQLEF
What is the function of this protein?
Key enzyme involved in DNA replication and DNA repair.  Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for fen1.  Is a target of the intra-S phase checkpoint, associating with stalled replication forks when phosphorylated at Ser-219 and preventing the stalled replication forks from reversing.  Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.  Also required for the production of G-rich single-strand overhangs at telomere ends and thus in telomere length maintenance.  Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities.  While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is atypical: it cannot load onto its tracking strand internally and has an absolute free 5'-end requirement.  Helicase activity may promote the motion of dna2 on the flap, helping the nuclease function.
What are the official names of this protein?
DNA replication ATP-dependent helicase/nuclease dna2.
What is the protein family that this protein belongs to?
Belongs to the DNA2/NAM7 helicase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Chromosome, telomere. Note=Recruited to double-strand. break (DSB) sites.
Protein: CYSG_SHIFL
Sequence: MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTLVEGPFDESLLDTCWLAIAATDDDTLNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRSPLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMSERRRFWEKLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQQADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLKGGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHLKTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVIDGTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
What is the function of this protein?
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1.  Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin.  Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
What are the official names of this protein?
Siroheme synthase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the precorrin methyltransferase family.
Protein: RL3_METBU
Sequence: MAKGHRPRRGSLAYSPRKRSQSHIPRFRSWPESDAEPKLQGFAGYKVGMTHVIMIDDVKHSLTEGTEISVPVTIIETPAIRVAAIRAYGKDTYGEIAIAEAWTDVLDKDLSRRLKTAKNPDVNASLEKLETLVESGRANDIRLITYTLPSTLTGVPKKVPDVMETGVSGSDVKAKFEYAKTVLGTMVEISDVFDNGKIVDVAAITTGHGTQGPVKRWGINLMKNKHSRQGSLRQVGTLGPWTPAHVSWRVPQAGQMGYHQRTDYNKRILKMSSDVDEVNPAGGFVNYGLVRGNYILIKGSVPGPSKRLIRLREPTRSKVSSIGEPQIMHVSTQTLQG
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.