PharMolix/UniProtQA huggingface dataset:
Protein: PIAS4_MOUSE
Sequence: MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDCSPELFKKIKELYETRYAKKSAEPGPQAPRPLDPLALHSMPRTPLSGPTVDYPVLYGKYLNGLGRLPTKTLKPEVRLVKLPFFNMLDELLKPTELVPQSAEKLQESPCIFALTPRQVEMIRNSRELQPGVKAVQVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMYLSSATNRITVTWGNYGKSYSVALYLVRQLTSSDLLQRLKTIGVKHPELCKALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVCDKPAAYDQLIIDGLLSKILSECEGADEIEFLAEGSWRPIRAEKEPSCSPQGPILVLGTSDANGLAPASSTPGIGSGLSGPGSAGSGAGAAGSLENGKTGADVVDLTLDSSSSSEDEDEDEDDDEDEDEGPRPKRRCPFQKGLVPAC
What is the function of this protein?
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor.  Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168.  Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway.  Involved in gene silencing.  In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.  Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (By similarity).  Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs) (PubMed:11731474).  Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR) (By similarity).  Mediates sumoylation of PARP1 in response to PARP1 trapping to chromatin (By similarity).
What are the official names of this protein?
E3 SUMO-protein ligase PIAS4, PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma, PIAS-gamma.
What is the protein family that this protein belongs to?
Belongs to the PIAS family.
What are the subcellular locations of this protein?
Nucleus, PML body. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies. Accumulates in the cytoplasm upon treatment with UVB and TNF-alpha.
Protein: IHFA_PSEMY
Sequence: MGALTKAEMAERLYEELGLNKREAKELVELFFEEIRQALELNEQVKLSGFGNFDLRDKRQRPGRNPKTGEEIPITARRVVTFRPGQKLKARVEAYAGTKS
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: PDI22_ORYSJ
Sequence: MAIPRISPRKTLPLFAALALALAWAFAAPAFADGDDVVALTESTFEKEVGQDRGALVEFYAPWCGHCKKLAPEYEKLGASFKKAKSVFIAKVDCDEHKSVCSKYGVSGYPTIQWFPKGSLEPKKYEGQRSAEALAEFVNTEGGTNVKLATIPSSVVVLGPDNFDSIVLDENKDILVEFYAPWCGHCKHLAPIYEKLASVYKLDDGVVIANLDADKHKDLAEKYGVSGYPTLKFFPKGNKAGEDYDGGRELDDFVKFINEKCGTSRDTKGQLTSEAGRIASLDALAKEFLGAANDKRKEILSNMEEEVVKLSGSAAKHGKVYIAIAKKILDKGHDYTKKETERLERMLEKSISPSKADEFIIKKNVLSTFSS
What is the function of this protein?
Acts as a protein-folding catalyst that interacts with nascent polypeptides to catalyze the formation, isomerization, and reduction or oxidation of disulfide bonds.  May play a role in storage protein biogenesis (By similarity).
What are the official names of this protein?
Protein disulfide isomerase-like 2-2, OsPDIL2-2, Protein disulfide isomerase-like 4-2, OsPDIL4-2.
What is the protein family that this protein belongs to?
Belongs to the protein disulfide isomerase family.
What are the subcellular locations of this protein?
Secreted.
Protein: YACG_DECAR
Sequence: MAVRKVRCPQCGKDALWAPENPWRPFCSERCKQIDLGCWASDSYRIPVPDDSNEPGTDPDPTSRA
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: LACG_STAA1
Sequence: MTKTLPEDFIFGGATAAYQAEGATNTDGKGRVAWDTYLEENYWYTAEPASDFYNRYPVDLELSEKFGVNGIRISIAWSRIFPNGYGEVNPKGVEYYHKLFAECHKRHVEPFVTLHHFDTPEVLHKDGDFLNRKTIDYFVDYAEYCFKEFPEVKYWTTFNEIGPIGDGQYLVGKFPPGIKYDFEKVFQSHHNMMVAHARAVKLFKDGGYQGEIGVVHALPTKYPFDPSNPEDVRAAELEDIIHNKFILDATYLGKYSRETMEGVQHILSVNGGKLNITDEDYAILDAAKDLNDFLGINYYMSDWMRGYDGESEITHNATGDKGGSKYQLKGVGQREFDVDVPRTDWDWMIYPQGLYDQIMRVVKDYPNYHKIYITENGLGYKDEFIESEKTVHDDARIDYVRQHLNVIADAIKDGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFETQERYPKKSAYWYKELAETKEIK
What are the official names of this protein?
6-phospho-beta-galactosidase, Beta-D-phosphogalactoside galactohydrolase, PGALase, P-beta-Gal, PBG.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 1 family.
Protein: RECA_STRR6
Sequence: MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGERAEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETTPGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMYGEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQVRSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs (By similarity).  It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity).  Required for DNA transformation; protects transforming DNA from degradation, possibly in combination with DprA (PubMed:14617176, PubMed:17803906).  Present at 15,000-30,000 monomers per competent cell (PubMed:14617176).
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_PYRCJ
Sequence: MSTAQRRLPVYKKILEENKKKWMIKEFLEYRLAKYGYIDSEILKTPLGTRIVIYAERPSRIIGRKGAIVKEVSSILANKLGVENPQIDVIDVSKIEAPELFPKVVAYRIANAMARGVRFRRVMFVAVRQLMEAGAKGFEIVVSGKLSTERAKFEKITYGKLYKIGYDAKNRVRRAVVHVLLKPGIYGIEVRITPATLRYSDEYKIKPPTRPEAAAQ
What is the function of this protein?
Binds the lower part of the 30S subunit head.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: NTPPA_PYRHO
Sequence: MMIILASSSPRRREILGRFFEIKVYPANVEERSTVKDSREKSLDIARKKALSVSSKFPGATIVAADTMVIFRGKTLGKPRNAEEARKMLRALSGNVHKVITGYCIIHNGRIIEGVEETEVKFREIGDELLEWYISTGEWKDKAGAYGIQGYASIFVEWIKGDYYNVVGLPIKVVVELTKLGFKPKR
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTPN2_MDBVW
Sequence: MQGPMKNTVADFWKVVWQQHSHVIVMLTKIKEGGNEKCHQYWCPYEDNLLVTEEYTIKTLRVTVRPNYIRTFLEITDKTTQRSRKITHFQCLHWPEHSMPSDLAWFIDFIKMTNRVRKAVHEDILGRFQRVF
What are the official names of this protein?
Tyrosine phosphatase-like protein N2, PTP-N2.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: DOHH_LENED
Sequence: MSLSATQLKALEDSVLNTSGKVLLHDRVRALFTLKSLKNEDAIRIISKGFQDSAALLKHELAYCLGQIRNPLALPVLESVLRNPSEDPMVRHEAAEAMGAISTADSIPILKQYLSDPDRSVRETCEIAIAKIEWDKTEEGAKNDKATRDENRLPLYTSIDPAPATSGLLTGAPRPEEISQTKIDELRDNLLDVNRPLFERYRAMFALRNIGSPAAVDALAAGFSGDSALFKHEIAFVFGQLLSPHSVPCLIEVLQNSPESDMVRHEAAEALGGIATPEVLPPLKEWVARDDAPVVVRESCQVALDLWEYENSGDFQYANGLESPSTPISV
What is the function of this protein?
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
What are the official names of this protein?
Deoxyhypusine hydroxylase, DOHH, Deoxyhypusine dioxygenase, Deoxyhypusine monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine hydroxylase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RBSA_BACSU
Sequence: MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTLMNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGKEISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEVIIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTVDTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRSGEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITENRKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHARHLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVSSELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR
What is the function of this protein?
Part of the ABC transporter complex RbsABC involved in ribose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Ribose import ATP-binding protein RbsA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RNPA_BRUA4
Sequence: MNKPKQILRLRKRAEFLALRNGEKRRGPLFLLEVRERTEEESQTAKIGEKPRAGFTVTKKNGNAVIRNRIRRRLREAVRCHAGRDMAPSTDYVIVAREQALTAPFSRLTEELSRRIKAKGERRGDGKRRTERPESGPVNGK
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: RECN_STRCO
Sequence: MRIRSLGVIDDAVVELSPGFTAVTGETGAGKTMVVTSLGLLLGGRADAALVRIGAKNAVVEGRIAVPGDAAVAVRAEEAGAELDDGALLISRTVSAEGRSRAHLGGRSVPVGMLAELADELVAVHGQTDQQGLLKLNRQRQALDRYAGDAVAGPLAKYAEAYRRLRAVVRELEEITTRARERAQEADLLRYGLDEIAAVEPRAGEDVELAEEAERLGHAEALASAATVAHAALAGNPEDPEGVDGATLVAGAQRALDAVRSHDPALAALAERIGEVGILLRDVAGELAGYADDLDADPLRLAAVEERRAALTALTRKYGEDIAAVLSWAEQSAARLTELDGDDERIGELTAERDALRAELGGLAQALTDARTEAAERFAAAVTAELASLAMPHARVSFAIRQTEDPEGVEIGGRTVAYGPSGADEVELLLAPHPGAPARPIAKGASGGELSRVMLAVEVVFAGTDPVPTYLFDEVDAGVGGKAAVEIGRRLARLARSAQVVVVTHLPQVAAFADRQLLVEKTNDGSVTRSGVKVLEGEERVRELSRMLAGQEDSETARAHAEELLETARADR
What is the function of this protein?
May be involved in recombinational repair of damaged DNA.
What are the official names of this protein?
DNA repair protein RecN, Recombination protein N.
What is the protein family that this protein belongs to?
Belongs to the RecN family.
Protein: YVEE_VACCC
Sequence: MITSIVNLCQILLVQRVTSVWRYPVRNIKPTNIEKFIHGGILYAAFLWLFYQPHICDGAFSIFNI
What are the official names of this protein?
Uncharacterized 7.6 kDa protein.
Protein: ATF2_CHICK
Sequence: MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRNKIEEPSVVETTHQDSPLPHPESTTNDEKEVSLQQTAQPTSTIVRPASLQVPNVLLTSSDSSVIIQQAIPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITNSNVHVPAAVPLVRPVTMVPSIPGIPGPSSPQPVQSEAKLRLKAALTQQHPQVTNGDTAKGHPSGLVRTQSEEPRPQSLQQPATSTTETPASPAQPTQQTPNTGGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQNEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQLADQSSEPGLPQVGVVPPSQAQPSGS
What is the function of this protein?
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response.  Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3') (By similarity).
What are the official names of this protein?
Cyclic AMP-dependent transcription factor ATF-2, cAMP-dependent transcription factor ATF-2, Activating transcription factor 2.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Mitochondrion outer membrane.
Protein: YE11A_YEAST
Sequence: MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELFLDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTARAHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY
What is the function of this protein?
Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome.  The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules.  CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription (By similarity).
What are the official names of this protein?
Transposon Ty1-ER1 Gag polyprotein, Gag-p49, Transposon Ty1 protein A, TY1A, TYA, p58.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S2545_MOUSE
Sequence: MPVEEFVAGWISGAVGLVLGHPFDTVKVRLQTQSTYQGIVDCVVKTYRHESVLGFFKGMSFPIASVALVNSVLFGVYSNTLLALTATSHQERRAQPPSYTNIFIAGCTGGLLQAYCLAPFDLIKVRLQNQTEPRMQISSSMPRYRGPVHCAASILREEGPQGLFRGSWALVLRDTPTLGMYFVTYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWITATPFDVIKSRMQMDGLKGRKYGGMLDCMASSFRQEGIGVFFKGMTLNSARAFPVNAATFLSYEYLLRLWR
What are the official names of this protein?
Solute carrier family 25 member 45.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: UL08_HCMVA
Sequence: MASDVSSHLLTVTQSRWTIHHMYNKLLILALFTPVILESIIYVSGPQGGNVTLVSNFTSNISARWFRWDGNDSHLICFYKRGEGLSTPYVGLSLSCAANQITIFNLTLNDSGRYGAEGFTRSGENETFLWYNLTVKPKPLETTTASNVTTIVTTTPTVIGTKSNVTGNASLAPQLRAVAGFLNQTPRENNTHLALGEGFVPTMTNPGLYASENYNGNYELTEAANTARTNSSDWVTLGTSASLLRSTETAVNPSNATTVTPQPVEYPAGEVQYQRTKTHYSWMLIIAIILIIFIIICLRAPQKVYDRWKDNKQYGQVFMTDTEL
What is the function of this protein?
Plays a role in the inhibition of pro-inflammatory cytokine prodution.  This effect is mediated by the conserved Ig-like domain.
What are the official names of this protein?
Membrane protein UL8.
What is the protein family that this protein belongs to?
Belongs to the RL11 family.
What are the subcellular locations of this protein?
Host cell membrane; Single-pass membrane protein.
Protein: LFTR_SHESM
Sequence: MNSLSFLNHEFEAFPSPELALTDPNGLLAIGGDLRPERLLTAYYHGIFPWFNADDPILWWSPDPRAIFIPGQVNISTSLRKYLKKQPWRFTINHAFTDVMAGCAQPRRKQAGTWITHEIQMAYRELHHNGHAHSVEVWHGERLIGGLYGLAIGQVFCGESMFHRETNASKAAMLLLQQHLINMDFKLIDAQVMNPHLESLGAKPVKRANFIQLLTQFRDNTANPAAWIPSEVTLEL
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PMYT1_HUMAN
Sequence: MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
What is the function of this protein?
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins.  Mediates phosphorylation of CDK1 predominantly on 'Thr-14'.  Also involved in Golgi fragmentation.  May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect.  May be a downstream target of Notch signaling pathway during eye development.
What are the official names of this protein?
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, Myt1 kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Protein: SUCA1_TRIVA
Sequence: MLAGDFSRNLHKPLLFIDKDTKVVIQGIGNQGQFHSRLMRQYGTKVVGAVHPKKAGTIIAGLPIFKNMKEVVKRTDANASLIFVPAPGAAAACIEAAEAGMGLVVCITEHIPQHDMIKVKKVMKETGCQLIGPNCPGLIQPGTHTKLGIIPTNIFNNGKIGIVSRSGTLTYEAAYATTLAGLGQSTVVGIGGDPFAGQLHTDVVKRFAADPQTEGIILIGEIGGTSEEDAAEWIAKTKLTQEKPVVASIAGATAPPGKRMGHAGAIVSGGKGTAEGKYKALEAAGVRIARHPGNMGKFIFEEMKRMGKI
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA.  The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial, Succinyl-CoA synthetase subunit alpha-1, SCS-alpha-1.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase alpha subunit family.
What are the subcellular locations of this protein?
Hydrogenosome lumen.
Protein: RIMP_MOOTA
Sequence: MSKLTALIQELVEPLLTPMGYELVDLQYGREGGRYILRLFIDRPEGIGLDDCEQVSRVVSALLDEKDPIPHSYYLEVSSPGLERPLKKEADFNRFAGRKVKLRTFAPINGQRHFQGRLLGYQDGQVRMHLEEGWDLAIPLEQVATARLVFDLADDEED
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_DESHD
Sequence: MIKYYDRKTQTYQIEKVAGEKMIRWTYSSPVGMRLLETVVKKRMCSSFYGWYLDRRISRRKIHPFVCKFDLDLSIAEKNLKDFSSFNDFFYRKLKPSARSIDPCQDSLISLGDGKLLAYEDINLDCLVQVKGLTYSLKELIKDPETASKYKRGTCLILRLCPTDYHRFHFIDSGICEPSHRIKGSYYSVNPVALQKVAKLFCENKREWSIFHSDHFGDILTIEVGATFVGSIIQSYTPHQPVARGDEKGYFKFGGSTVLLFFEENKIKIDPDIVEQTKLGYETYILFGEKIGVRHKGR
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type II sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: TXP1_PSACA
Sequence: EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT
What is the function of this protein?
This toxin is a gating modifier that acts principally as an inhibitor on ASIC1a (ASIC isoform 2) and a potentiator on ASIC1b (ASIC isoform 3) (PubMed:10829030, PubMed:15955877, PubMed:21036899).  This toxin potently and selectively inhibits rat, mouse and human ASIC1a (IC(50)=0. 35-3. 7 nM) (PubMed:10829030, PubMed:15955877, PubMed:21715637, PubMed:26248594, PubMed:21825095).  The blockade is rapidly reversible (PubMed:10829030, PubMed:28320941).  The toxin acts by shifting its steady-state desensitization to more alkaline pH (0. 27 pH unit) (PubMed:15955877, PubMed:16505147).  At higher concentrations, it potentiates rat and human ASIC1b and activates chicken ASIC1 by stabilizing the open state of these subtypes (PubMed:16505147, PubMed:21036899, PubMed:19185346, PubMed:24262969, PubMed:22842900).  The toxin binds most tightly to the open and the desensitized states of ASIC1a (promoting desensitization), whereas it binds most tightly to the open state of ASIC1b (promoting opening) (PubMed:16505147).  The toxin also inhibits mouse ASIC1a-ASIC2b (IC(50)=2. 64 nM) and rat ASIC1a-ASIC2a (PubMed:21715637, PubMed:27277303).  It binds to the extracellular domain at subunit interfaces in the acidic pocket with the majority of contacts on the thumb domain of the channel (PubMed:21825095, PubMed:22842900, PubMed:22760635).  It is also noteworthy that calcium competes with the toxin, probably by inhibiting binding of the toxin to the channel (PubMed:15955877).
What are the official names of this protein?
Psalmotoxin-1, PcTx1, Pi-theraphotoxin-Pc1a, Pi-TRTX-Pc1a.
What is the protein family that this protein belongs to?
Belongs to the psalmotoxin-1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RECO_BACFN
Sequence: MLQKTVGIVLHVLKYNDTSNIVEMYTELSGRASFLVTVPRSKKATVKSVLFQPLALIEFEADYRPNTSLFRIKEAKSFSPFTSIPYDPFKSAIALFLAEFLYRAIREEAENRPLFAYLQHSILWLDTCKISFANFHLVFLMRLSRFLGLYPNLDDYHAGDYFDMLNATFTSVRPQLHSSYIQPDEAGRLLQLMRMNYETMHLFGMNRTERARCLAIINEYYRLHLPDFPILKSLDVLKELFD
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: EFTS_CLOPS
Sequence: MITAKAVKELRERTGAGMMDCKKALTETNGDMEKAVEVLREKGLAAAAKKAGRVAAEGIVKTYVSEDMKKGSIVEINCETDFVALNEEFVGFAGRVAELVANSNVNTVEELLAEKLDGDKTVQEVLTELIAKIGENMSVRRFERFSVESGLVQSYIHGGGRIGVMAELACEASSPVLAEVAKDVCMQIAAANPLFLSEADVDQESLEKEKEIYRAQALNEGKPEHIVDKMVMGRIKKYCKEVCLLDQAWVKDGDKSISKLLEEKSKEVGSPITITKFVRFERGEGIEKKEENFAEEVAKMGGK
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_LIMRD
Sequence: MKSKDYVQELNGLTTDKLLDREKELKEQLFNLRFQLATGQLENTASLKQVRKDIARVKTVLRQQELNK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.