PharMolix/UniProtQA huggingface dataset:
Protein: SSDH_PANPA
Sequence: MATCIWLRSCGARRLGWTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGGLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCCWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIYTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
What is the function of this protein?
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
What are the official names of this protein?
Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CP11A_HUMAN
Sequence: MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
What is the function of this protein?
A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:21636783).  Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:21636783).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule.  Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:21636783).
What are the official names of this protein?
Cholesterol side-chain cleavage enzyme, mitochondrial, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc).
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane.
Protein: Y767_BACMK
Sequence: MTKNIHDVAYELQKTIAENEDFQTLKASYAAVQGDAESKNLFEEFRAMQLGLQQKMMQGQEITEEDNQKAQEVVARIQQDAKITKLMETEQRLNIVITDVNKIIMKPLEELYSAQQA
What are the official names of this protein?
UPF0342 protein BcerKBAB4_0767.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: BIOB_ARATH
Sequence: MMLVRSVFRSQLRPSVSGGLQSASCYSSLSAASAEAERTIREGPRNDWSRDEIKSVYDSPLLDLLFHGAQVHRHVHNFREVQQCTLLSIKTGGCSEDCSYCPQSSRYSTGVKAQRLMSKDAVIDAAKKAKEAGSTRFCMGAAWRDTIGRKTNFSQILEYIKEIRGMGMEVCCTLGMIEKQQALELKKAGLTAYNHNLDTSREYYPNVITTRSYDDRLETLSHVRDAGINVCSGGIIGLGEAEEDRIGLLHTLATLPSHPESVPINALLAVKGTPLEDQKPVEIWEMIRMIGTARIVMPKAMVRLSAGRVRFSMSEQALCFLAGANSIFTGEKLLTTPNNDFDADQLMFKTLGLIPKPPSFSEDDSESENCEKVASASH
What are the official names of this protein?
Biotin synthase, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ECFA1_MESM1
Sequence: MSTDNINTPMIELKNVKFKYSTGTSFALNDVSINFPQGKYTAILGHNGSGKSTLSKIIAGLYKPTSGDVYIDGIKLQRSTLRKLQEKIGIIFQNPDNQFIGATVEDDIAFGLENKLIPRNEMKKIILDLSKRVGMDKYLDREPQYLSGGQKQRVAIASILALDPEIIIFDEVTSMLDPKGKKEVLKLIREIQQTRKKTLISITHDMDEAILADRVLVLAEGELIASGDPLEILKNERVIEIAKIDSPFIYRVSKLLKNVDPTYDQDKLIGEICK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
Protein: Y1186_STRA1
Sequence: MYHIELKKEALLPRERLVDLGADRLSNQELLAILLRTGIKEKPVLEISTQILENISSLADFGQLSLQELQSIKGIGQVKSVEIKAMLELAKRIHKAEYDRKEQILSSEQLARKMMLELGDKKQEHLVAIYMDTQNRIIEQRTIFIGTVRRSVAEPREILHYACKNMATSLIIIHNHPSGSPKPSESDLSFTKKIKRSCDHLGIVCLDHIIVGKNKYYSFREEADIL
What are the official names of this protein?
UPF0758 protein SAK_1186.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: HEMT1_GOLVU
Sequence: MGFPIPDPYVWDPSFRTFYTAIDDEHKTLFDGIFHLARDDNKDNLGELRRCTGKHFLNEQVMMQASQYAGYDEHKKAHDEFIHQLDHWKGDSNWAKTWLVNHIKTIDFKYKGKI
What is the function of this protein?
Hemerythrin is a respiratory protein in blood cells of certain marine worms.  The oxygen-binding site in each chain contains two iron atoms (By similarity).
What are the official names of this protein?
Hemerythrin subunit 1, Hr 1.
What is the protein family that this protein belongs to?
Belongs to the hemerythrin family.
Protein: RS21_RICRO
Sequence: MILVNVHAGNCDNTLKNFKKKLQRELYFRKMKEQRYYETPSAKRVRKAQEAARRQRKFARKKMFDE
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: PCYA_CROS5
Sequence: MTTVKTSPTTLPLHPLIHQLAEVIISHWQDYLDLSPYELPDGLGYVEGKLEGEKLVIENRCYQSPQFRKMHLELAKVGQGLDILHCVMFPNPDYALPMFGCDIVAGKGGVSAAIADLSPANPELTLSNSYNQALSQLETPNFSDQRELPEWGDIFSEYCLFIRPHTPEEEKLFLKRVGDFLKVHCQQANQSQPGSTQQREFNIQGQEYYCRKQQQNDKTRRVLEKAFGEAWANKYMTQVLFDIPNH
What is the function of this protein?
Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin.
What are the official names of this protein?
Phycocyanobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: SELO_VIBA3
Sequence: MSVWDSISFNNRFTALPRLFYTPIQPTPLNNVQWLAWNHNLANELGFPSFECTSEELLETLSGNVEPEQFSPVAMKYAGHQFGSYNPDLGDGRGLLLAQVVAKSGETFDLHLKGAGKTPYSRMGDGRAVIRSTVREYLCSEAMAGLNIPTTRALAMMTSDTPVYREKQEWGALLVRAAESHIRFGHFEHLFYTNQLAEHKLLADKVIEWHFPECLDDDKPYAAMFNQIVDRTAEMVALWQANGFAHGVMNTDNMSIIGQTFDYGPFAFLDEYDPRLICNHSDYQGRYAFNQQPRIGLWNLSALAHSLSPLVDKADLEAALEQYEPQMNGYFSQLMRRKLGLLSKHEGDSRLFESMFELMSQNKVDYPRFFRTLSNLDTLLPQDVIDLVIDREAAKLWVDNYLQRCELEESSVAERCEKMRQVNPKYILRNYLAQLAIDKAERGDSSDIDALMVVLADPYAEHPDYEHLAALPPEWGKAMEISCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: ARO1_YEAST
Sequence: MVQLAKVPILGNDIIHVGYNIHDHLVETIIKHCPSSTYVICNDTNLSKVPYYQQLVLEFKASLPEGSRLLTYVVKPGETSKSRETKAQLEDYLLVEGCTRDTVMVAIGGGVIGDMIGFVASTFMRGVRVVQVPTSLLAMVDSSIGGKTAIDTPLGKNFIGAFWQPKFVLVDIKWLETLAKREFINGMAEVIKTACIWNADEFTRLESNASLFLNVVNGAKNVKVTNQLTNEIDEISNTDIEAMLDHTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVKEAELSRYFGILSPTQVARLSKILVAYGLPVSPDEKWFKELTLHKKTPLDILLKKMSIDKKNEGSKKKVVILESIGKCYGDSAQFVSDEDLRFILTDETLVYPFKDIPADQQKVVIPPGSKSISNRALILAALGEGQCKIKNLLHSDDTKHMLTAVHELKGATISWEDNGETVVVEGHGGSTLSACADPLYLGNAGTASRFLTSLAALVNSTSSQKYIVLTGNARMQQRPIAPLVDSLRANGTKIEYLNNEGSLPIKVYTDSVFKGGRIELAATVSSQYVSSILMCAPYAEEPVTLALVGGKPISKLYVDMTIKMMEKFGINVETSTTEPYTYYIPKGHYINPSEYVIESDASSATYPLAFAAMTGTTVTVPNIGFESLQGDARFARDVLKPMGCKITQTATSTTVSGPPVGTLKPLKHVDMEPMTDAFLTACVVAAISHDSDPNSANTTTIEGIANQRVKECNRILAMATELAKFGVKTTELPDGIQVHGLNSIKDLKVPSDSSGPVGVCTYDDHRVAMSFSLLAGMVNSQNERDEVANPVRILERHCTGKTWPGWWDVLHSELGAKLDGAEPLECTSKKNSKKSVVIIGMRAAGKTTISKWCASALGYKLVDLDELFEQQHNNQSVKQFVVENGWEKFREEETRIFKEVIQNYGDDGYVFSTGGGIVESAESRKALKDFASSGGYVLHLHRDIEETIVFLQSDPSRPAYVEEIREVWNRREGWYKECSNFSFFAPHCSAEAEFQALRRSFSKYIATITGVREIEIPSGRSAFVCLTFDDLTEQTENLTPICYGCEAVEVRVDHLANYSADFVSKQLSILRKATDSIPIIFTVRTMKQGGNFPDEEFKTLRELYDIALKNGVEFLDLELTLPTDIQYEVINKRGNTKIIGSHHDFQGLYSWDDAEWENRFNQALTLDVDVVKFVGTAVNFEDNLRLEHFRDTHKNKPLIAVNMTSKGSISRVLNNVLTPVTSDLLPNSAAPGQLTVAQINKMYTSMGGIEPKELFVVGKPIGHSRSPILHNTGYEILGLPHKFDKFETESAQLVKEKLLDGNKNFGGAAVTIPLKLDIMQYMDELTDAAKVIGAVNTVIPLGNKKFKGDNTDWLGIRNALINNGVPEYVGHTAGLVIGAGGTSRAALYALHSLGCKKIFIINRTTSKLKPLIESLPSEFNIIGIESTKSIEEIKEHVGVAVSCVPADKPLDDELLSKLERFLVKGAHAAFVPTLLEAAYKPSVTPVMTISQDKYQWHVVPGSQMLVHQGVAQFEKWTGFKGPFKAIFDAVTKE
What is the function of this protein?
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
What are the official names of this protein?
Pentafunctional AROM polypeptide.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the shikimate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_BACSU
Sequence: MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKHSKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLDK
What is the function of this protein?
Has also been isolated as a basic, heat-shock stable DNA-binding protein from the B. subtilis nucleoid.  It binds cooperatively to double-stranded supercoiled DNA which it further compacts into complexes 15-17 nm in diameter.  Overexpression of the protein disrupts nucleoid segregation and positioning.
What are the official names of this protein?
50S ribosomal protein L24, 12 kDa DNA-binding protein, BL23, HPB12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, nucleoid. Note=Is located predominantly at the nucleoid poles during exponential phase, while in stationary phase the protein is more evenly distributed in the whole cell.
Protein: FOXJ1_XENTR
Sequence: MFDLPTVAPIDMEDSWVTFQAEGEQGQDSFSSSVNLDDSLTSLQWLQEFSILNANVGKAPSSGDSHGYKHLFGAPCSPLAADPACLGMPHTPGKPISSSTSRASHLGLQPMEDIDYKTNPHVKPPYSYATLICMAMQASKKTKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWKIDPQYADRLMNGAMKKRRLPPVQIHPAFASAQAAASGNSNRGSPWQLSVNSESHQLLKEFEEATGEQGWNALGEHGWNAISDGKSHKRKQPLPKRMFKAPRLSSSPMLCQEEQTELGSLKGDFDWEVIFDSSMNGVNFSAFEDLEVTPPLSPVTRSVDLTVHGKHIDCPQQWYPLGQDQAVVQNSLDFDETFLATSFLQHPWEENRNDYLSNSANIEQLFDLNEEFPAELNDWSALGSYI
What is the function of this protein?
Key transcription factor required for motile ciliogenesis.  Activates genes essential for motile cilia formation and function.
What are the official names of this protein?
Forkhead box protein J1, FoxJ1.
What is the protein family that this protein belongs to?
Belongs to the FOXJ1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: EGY2_ARATH
Sequence: MNLAVASFRGNFGVLSQCSSCCSLQFQPFVAATSSLNFGQTGTSRRKKDLKLERVFRKRETLVRVTETQTEPEGNDDEDNKEGKESSADDPPTKIPTELNSQSTVVNEAPGNEEENKAQFSSQDGDKLEVSSGSPLPGVNVSIIIHVIYKDDSIMFSGCLSFIKSCCEQPLQLDDSMRLPKETIDILRGQVFGFDTFFVTSQEPYEGGVLFKGNLRGKPATSYEKIKTRMENNFGDQYKLFLLTNPEDDKPVAVVVPRRSLEPETTAVPEWFAAGSFGLVALFTLFLRNVPALQSDLLSAFDNLELLKDGLPGALVTALVLGVHELGHILVANSLGIKLGVPFFVPSWQIGSFGAITRIKNIVAKREDLLKVAAAGPLAGFSLGLILFLIGLFVPPSDGIGVVVDASVFHESFLAGGIAKLLLGDALKEGTSISLNPLVIWAWAGLLINGINSIPAGELDGGKIAFSIWGRKTATRLTGASIALLGLSALFSDVAFYWVVLIFFLQRGPIAPLAEEITVPDDKYVSLGILVLFLSLLVCLPYPFAFTGNEAMMIGL
What is the function of this protein?
Probable membrane-associated metalloprotease that may be involved in chloroplast development.
What are the official names of this protein?
Probable zinc metalloprotease EGY2, chloroplastic, Protein ETHYLENE-DEPENDENT GRAVITROPISM-DEFICIENT AND YELLOW-GREEN 2.
What is the protein family that this protein belongs to?
Belongs to the peptidase M50B family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: SUMO1_RAT
Sequence: MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV
What is the function of this protein?
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer.  Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4.  This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction.  Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2.  Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1.  Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.  May also regulate a network of genes involved in palate development.  Covalently attached to ZFHX3.
What are the official names of this protein?
Small ubiquitin-related modifier 1, SUMO-1.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family. SUMO subfamily.
What are the subcellular locations of this protein?
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane. Nucleus. Note=Recruited by BCL11A into the nuclear body (By similarity). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (By similarity).
Protein: SMCO4_HUMAN
Sequence: MRQLKGKPKKETSKDKKERKQAMQEARQQITTVVLPTLAVVVLLIVVFVYVATRPTITE
What are the official names of this protein?
Single-pass membrane and coiled-coil domain-containing protein 4, Protein FN5.
What is the protein family that this protein belongs to?
Belongs to the SMCO4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: THIE_PSEFS
Sequence: MKLRGLYAITDSQLLAGKFLAYVEAALDGGVTLLQYRDKSSDEARRLREAEKLRELCSRYKTQLIINDDAELAARLGVGVHLGQTDGPLTPARALLGSKAIIGSTCHSQIELAEQAAKEGASYVAFGRFFNSNTKPGAPAATVEMLAQARARVQLPICVIGGITLENAEPLVAHGADLLAVVHGLFGADSTQEVTRRARAFNDLLKISV
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: TRKI_HALED
Sequence: MADTRRVTDTLRRWAPILKVLAVLWLVLAIFMAIPLLVLIVESEPDALAFGLSIAIVLAAATLSWIVTWRIPVSLKPWQMFVLTTLSWVTISSFASLPLVLGAPQLSLTNAVFESVSAITTTGSTILVHIEDLSDGLKLWRGIMQWLGGIGIIVMGIAILPFLKVGGMRLFHTESSDWSDKVMPRTGGIAKATLSIYCGFTLLAAMAYYLGGMSPLDAVVHAMTSLATGGFANSDASFGAYAEQPQLLWMGSLFMLCGALPFVLYIRFLRGSRMALLRDQQVQGLLLLLLLVILALTIWRVSQGTPAFTSLTQVTFNVVSVVTTTGYASDDYSAWGATAYVAFFYLTFVGGCSGSTSGGMKIFRFQVAMLLLRDQLRYLIHASGVFVSRYNNQPLTDDITRGVVAFSFFFFLTVAGLALGLSLLGLDFTTALSGAATAVANVGPGLGETIGPAGNFAPLPDAAKWLLCVGMLMGRLEILTVLVLLTPMFWRQ
What is the function of this protein?
Medium-affinity potassium transport system.  Probably interacts with Trk system potassium uptake protein TrkA.  Main K(+) transporter in osmotically adapted cells.
What are the official names of this protein?
Trk system potassium uptake protein TrkI.
What is the protein family that this protein belongs to?
Belongs to the TrkH potassium transport family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: Y010_PYRHO
Sequence: MVFKIKDEWGEFLVRLARRAIEEYLKTGKEIEPPKDTPPELWEKMGVFVTLNRYNVPPQTALRGCIGFPTPIYPLVEATIKAAIYSAVDDPRFPPVKLEEMDNLVVEVSVLTPPELIEGPPEERPRKIKVGRDGLIVEKGIYSGLLLPQVPVEWGWDEEEFLAETCWKAGLPPDCWLDEDTKVYKFTAEIFEEEYPRGPIKRKPLV
What are the official names of this protein?
Protein PH0010.
Protein: GP4D_CHLT2
Sequence: MQNKSKVRDDFIKIVKDVKKDFPELDLKIRVNKEKVTFLNSPLELYHKSVSLILGLLQQIENSLGLFPDSPVLEKLEDNSLKLKKALIMLILSRKDMFSKAE
What are the official names of this protein?
Virulence plasmid protein pGP4-D, Protein P-8.
Protein: VSGP_EBOG4
Sequence: MGVTGILQLPRDRFKRTSFFLWVIILFQRTFSIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLEGNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNLEIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDFAFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQAKKDFFSSHPLREPVNATEDPSSGYYSTTIRYQATGFGTNETEYLFEVDNLTYVQLESRFTPQFLLQLNETRYTSGKRSNTTGKLIWKVNPEIDTTIGEWAFWETKKTSLEKFAVKSCLSQLYQTEPKTSVVRVRRELLPTQGPTQQLKTTKSWLQKIPLQWFKCTVKEGKLQCRI
What is the function of this protein?
Viroporin that permeabilizes mammalian cell plasma membranes.  It acts by altering permeation of ionic compounds and small molecules.  This activity may lead to viral enterotoxic activity.
What are the official names of this protein?
Pre-small/secreted glycoprotein, pre-sGP.
What is the protein family that this protein belongs to?
Belongs to the filoviruses glycoprotein family.
What are the subcellular locations of this protein?
[Small/secreted glycoprotein]: Secreted. SUBCELLULAR LOCATION: [Delta-peptide]: Secreted.
Protein: RDRP_I97A0
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGRWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGLFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLTKKSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVHFVEALARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTVTGDNTKWNENQNPRIFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNESTRKKIEKIRPLLIEGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEVESVNNAVVMPAHGPARSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCTLFEKFFPSSSYRRPVGISSMMEAMVSRARIDARIDFESGRIKKEEFAEILKICSTIEELGRQGK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: RABE2_PONAB
Sequence: MAAAAPVAADDDERRRRPGAALEDSRPQEGANGEAELGELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYEAQITALKQERQQQQQDCEEKERELGRLKQLLSRAHPLDSLEKQMEKAHEDSEKLREIVLPMEKEIEELKAKLLRAEELIQEIQRRPQHVPSLHGSTELLPLSRDPSPPLEPLEELSGDGGPAAEAFAHNCDDSASISSFSLGGGVGSSSSLPRSRQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDTQWEQLQMEGRQLQKDLESVSRERDELQEGLRRSNEDCAKQMQVLLAQVQNAEQLLRTLQGTVSQAQERVQLQMAELVTTHKCLHHEVKRLNEENQGLRAEQLPSSAPQGPQQEQGEEESLPSSVPELQQLLCRTRQEARAQLQAQEHGAERLRIEIVTLREALEEETAARASLEGQLRVQREETEVLEASLCSLRTEMERVQQEQSKPQLPDLLSEQRAKVLRLQAELETSEQVQRDFVRLSQALQVRLERIRQAETLEQVHSIMDEAPLTDVRDIKDT
What is the function of this protein?
Plays a role in membrane trafficking and in homotypic early endosome fusion.  Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking.  By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis.
What are the official names of this protein?
Rab GTPase-binding effector protein 2.
What is the protein family that this protein belongs to?
Belongs to the rabaptin family.
What are the subcellular locations of this protein?
Cytoplasm. Early endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.
Protein: VA0D2_DROME
Sequence: MSMIFNTEYGYLEALTRGFKNGMLKHSDYLNLTQCESLEDVMISIQGTDYGLIFGGEQSAPSVEVIERCLRDRLLQQYYYIRSHSTEPLTTFMEFIRYPFMIDNVALLVAGLNNHRSMKRLLRMCHPLGEFDQLGAIEVASNSAELFDAVLIDTPIARFVPRDLPMESLRYLDVEIVRAHLYRAYLEKFYAYCSQLGGNTANVMTNLLSFEADRRTITIAVNAIGSDIIPKERLKMFPTCGYLPKIALASMSTLNDTDKIRDVCNVFDGYGKMFDNLERDSDGMITLEDRFLMMEAKKNVQTFLQQYHFGIFYSFIKLKQLEVRNIVWISECIAQRQTDRINAFIPIPLD
What is the function of this protein?
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons.  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).  May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
What are the official names of this protein?
Probable V-type proton ATPase subunit d 2, V-ATPase subunit d 2, Vacuolar H+ ATPase subunit AC39-2, Vacuolar proton pump subunit d 2.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
Protein: VC02_VACCC
Sequence: MESVIFSINGEIIQVNKEIITASPYNFFKRIQDHHLKDEAIILNGINYHAFESLLDYMRWKKINITINNVEMILVAAVIIDVPPVVDLCVKTMIHNINSTNCIRMFNFSKRYGIKKLYNASMSEIINNITAVTSDPEFGKLSKDELTTILSHEDVNVNHEDVTAMILLKWIHKNPNDVDIINILHPKFMTNTMRNAISLLGLTISKSTKPVTRNGIKHNIVVIKNSDYISTITHYSPRTEYWTIVGNTDRQFYNANVLHNCLYIIGGMINNRHVYSVSRVDLETKKWKTVTNMSSLKSEVSTCVNDGKLYVIGGLEFSISTGVAEYLKHGTSKWIRLPNLITPRYSGASVFVNDDIYVMGGVYTTYEKYVVLNDVECFTKNRWIKKSPMPRHHSIVYAVEYDGDIYVITGITHETRNYLYKYIVKEDKWIELYMYFNHVGKMFVCSCGDYILIIADAKYEYYPKSNTWNLFDMSTRNIEYYDMFTKDETPKCNVTHKSLPSFLSNCEKQFLQ
What are the official names of this protein?
Kelch repeat protein C2.
What is the protein family that this protein belongs to?
Belongs to the poxviruses Kelch family.
Protein: RU2B_HUMAN
Sequence: MDIRPNHTIYINNMNDKIKKEELKRSLYALFSQFGHVVDIVALKTMKMRGQAFVIFKELGSSTNALRQLQGFPFYGKPMRIQYAKTDSDIISKMRGTFADKEKKKEKKKAKTVEQTATTTNKKPGQGTPNSANTQGNSTPNPQVPDYPPNYILFLNNLPEETNEMMLSMLFNQFPGFKEVRLVPGRHDIAFVEFENDGQAGAARDALQGFKITPSHAMKITYAKK
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346).  Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubMed:9716128).
What are the official names of this protein?
U2 small nuclear ribonucleoprotein B'', U2 snRNP B''.
What is the protein family that this protein belongs to?
Belongs to the RRM U1 A/B'' family.
What are the subcellular locations of this protein?
Nucleus.