PharMolix/UniProtQA huggingface dataset:
Protein: GACS_PSEPH
Sequence: MLKKLGIKGRVLLLTLLPTSLMALVLGGYFTWMQLSDLQTQLLQRGEMIAEQLASLVAPAMGNHNTQMLERIATQALEQQDVRAVSLLAPDRSLLAHAGPSMLNPPPAGNSSHMMQRSGSDATRYQLPVFGRHRNLAGDLIPDESDRLLGWVELELSHSGMLLRGYRSLFASLLLIAAGLAGTALLAVRMGRTINNPLTQIKQAVAQLKDGNLETRLPPLGSQELDELASGINRMASTLQNAQEELQHSIDQATEDVRQNLETIEIQNIELDLARKEALEASRIKSEFLANMSHEIRTPLNGILGFTHLLQKSELTPRQLDYLGTIEKSADSLLGIINEILDFSKIEAGKLVLDSIPFNLRDLLQDTLTILAPAAHAKQLELVSLVYRDTPLSLVGDPLRLKQILTNLVSNAIKFTREGTIVARAMLEEEHEDSVQLRISIQDTGIGLSNQDVRALFQAFSQADNSLSRQPGGTGLGLVISKRLIEQMGGEIGVDSTPGEGSEFWISLNLPKTRDDAEDLPGPPLLGRRVAVLENHELARQALQHQLEDCGLEVTPFNTLEALTNGITGVHQSEQAIDLAVLGITTNDMSPERLSQHIWDLEHLGCKVLVLCPTTEQTLFHLSVPNPHSQLQAKPACTRKLRRALSDLVTPRRARSEPEETLSSRAPRVLCVDDNPANLLLIQTLLEDMGAKVLAVDNGYAALNAIQTEPFDLVMMDVQMPGMDGRQSTEAIRQWESERHGTPLPIVALTAHAMANEKRALLQSGMDDYLTKPISERQLAQVVLKWTGLALRNQGPERASERPELGLELQVLDQDEGLRLAAGKADLAADMLAMLLASLDADREAIKAARAANDQNALIERVHRLHGATRYCGVPQLRAACQRSETLLKQEDAKAFAALDELDHAIGRLAAEARTNA
What is the function of this protein?
Member of the two-component regulatory system GacA/GacS which controls the expression of secondary metabolites and extracellular products.  Activates GacA by phosphorylation (Probable).  GacA acts (probably primarily) by activating expression of CsrA1 and CsrA2 antagonist small RNAs (sRNA) RsmX, RsmY and RsmZ which bind to and prevent translation repression by CsrA1 and CsrA2 (PubMed:11807065, PubMed:14622422, PubMed:15601712, PubMed:16286659).  Involved in the regulation of secondary metabolism and in the synthesis of the antifungal factors cyanide, 2,4-diacetylphloroglucinol and pyoluteorin (PubMed:15601712).  Exercises positive post-transcriptional control over the hcnABC and aprA genes; acts upstream of CsrA2 (rsmA) (PubMed:10570200).  Controls expression of CsrA1 and CsrA2 antagonist sRNAs RsmX, RsmY and probably RsmZ (PubMed:11807065, PubMed:14622422, PubMed:15601712, PubMed:16286659).  Probably controls expression of csrA1 (rsmE) and csrA2 (PubMed:15601712).
What are the official names of this protein?
Sensor histidine kinase GacS.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SC61B_MOUSE
Sequence: MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIAAVFMLHIWGKYTRS
What is the function of this protein?
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity).  Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity).  The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (By similarity).  The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity).  Required for PKD1/Polycystin-1 biogenesis (PubMed:28375157).
What are the official names of this protein?
Protein transport protein Sec61 subunit beta.
What is the protein family that this protein belongs to?
Belongs to the SEC61-beta family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: RS7_PSEAE
Sequence: MPRRRVAAKREVLADPKYGSQILAKFMNHVMESGKKAVAERIVYGALDKVKERGKADPLETFEKALDAIAPLVEVKSRRVGGATYQVPVEVRPSRRNALAMRWLVDFARKRGEKSMALRLAGELLDAAEGKGAAVKKREDVHRMAEANKAFSHYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: REHYA_ORYSI
Sequence: MPGLTIGDTVPNLELDSTHGKIRIHDFVGDTYIILFSHPGDFTPVCTTELAAMAGYAKEFDKRGVKLLGISCDDVQSHKDWIKDIEAYKPGNRVTYPIMADPSREAIKQLNMVDPDEKDSNGGHLPSRALHIVGPDKKVKLSFLYPSCVGRNMDEVVRAVDALQTAAKHAVATPVNWKPGERVVIPPGVSDDEAKEKFPQGFDTADLPSGKGYLRFTKVG
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity).  Seems to contribute to the inhibition of germination during stress (By similarity).
What are the official names of this protein?
1-Cys peroxiredoxin A, 1-Cys Prx A, Protein RAB24, Rice 1Cys-peroxiredoxin, R1C-Prx, Thioredoxin peroxidase A, Thioredoxin-dependent peroxiredoxin A.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. Prx6 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: VIP_SCYCA
Sequence: HSDAVFTDNYSRIRKQMAVKKYINSLLA
What is the function of this protein?
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
What are the official names of this protein?
Vasoactive intestinal peptide, VIP, Vasoactive intestinal polypeptide.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted.
Protein: ANXA1_CAVCU
Sequence: MSMVSEFLKQAYFIDNQEQDYVKTVKSSKGGPGSAVSPYPSFDASSDVAALHKAITVKGVDEATIIDILTKRNNAQRQQIKAAYLQEKGKPLDEALKKALTGHLEEVVLALLKTPAQLDADELRAAMKGLGTDEDTLIEILVSRKNREIKEINRVYRDELKRDLAKDITSDTSGDFQKALLSLAKGDRCEDLSVNDDLADSDARALYEAGERRKGTDVNVFITILTTRSYSHLRRVFQKYTKYSQHDMNKALDLELKGDIENCLTAIVKCATSTPAFFAEKLHLAMKGAGTRHKALIRIMVSRSEIDMNDIKVYYQKMYGISLCQAILDETKGDYEKILVALCGGQ
What is the function of this protein?
Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades.  Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors.  Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration.  Promotes resolution of inflammation and wound healing.  Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
What are the official names of this protein?
Annexin A1, Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, Lipocortin I, Lipocortin-like 33 kDa protein, Phospholipase A2 inhibitory protein, p35.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium. Basolateral cell membrane. Lateral cell membrane. Cell membrane; Peripheral membrane protein. Apical cell membrane. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Secreted. Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Secreted, extracellular exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup. Note=Colocalizes with actin fibers at phagocytic cups. Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles. Secretion is increased in response to wounding and inflammation (By similarity). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity). Detected in gelatinase granules in resting neutrophils. Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect. Displays calcium-dependent binding to phospholipid membranes (PubMed:2962884).
Protein: GMHA_ECOLU
Sequence: MYQDLIRNELNEAAETLANFLKDDANIHAIQRAAVLLADSFKAGGKVLSCGNGGSHCDAMHFAEELTGRYRENRPGYPAIAISDVSHISCVGNDFGFNDIFSRYVEAVGREGDVLLGISTSGNSANVIKAIAAAREKGMKVITLTGKDGGKMAGTADIEIRVPHFGYADRIQEIHIKVIHILIQLIEKEMVK
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SHH_DANRE
Sequence: MRLLTRVLLVSLLTLSLVVSGLACGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNHWPGVKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSALVSLQDGGQKAVKDLNPGDKVLAADSAGNLVFSDFIMFTDRDSTTRRVFYVIETQEPVEKITLTAAHLLFVLDNSTEDLHTMTAAYASSVRAGQKVMVVDDSGQLKSVIVQRIYTEEQRGSFAPVTAHGTIVVDRILASCYAVIEDQGLAHLAFAPARLYYYVSSFLFPQNSSSRSNATLQQEGVHWYSRLLYQMGTWLLDSNMLHPLGMSVNSS
What is the function of this protein?
The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development (By similarity).  Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes (PubMed:7583153).  Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity).  In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (By similarity).
What are the official names of this protein?
Sonic hedgehog protein, SHHA, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhNC, VHH-1.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Sonic hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=Co-localizes with HHAT in the ER and Golgi membrane. SUBCELLULAR LOCATION: [Sonic hedgehog protein A N-product]: Cell membrane; Lipid-anchor. Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (By similarity). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides.
Protein: ARLY_PETMO
Sequence: MKLWGGRFKEKIAEDMEIFNSSINVDIRLLPYDIEASLAHAEGLKKAKIISEEEFEQIERALREIKEEKFEEIPKVEDVHTLVEQMLVEKIGDVGKKIHTARSRNDQIATDERMYLRNEIFKIIDLLEQLNVVLVELSKKYKNKIMPGYTHMQRAQPITFSHHLLAYVEMFKRDIDRLKDSLKRVNVSVLGSGALAGTSYDIDRTYVASLLGFNEVSLNSIDGVSDRDFIVEFLSIASLIMMHLSRFSEEIVLWSSQEFNFVELSDEYSTGSSIMPQKKNPDSAELIRGKTGRVYGNLLSLLTTMKGLPLAYNKDMQEDKEPLFDTVDTLKVCLKVFIGMLKTMSVNEEKMKQAVKFGYLNATDLADYLVKKGIPFRNAHDIVGKLVAYAITKKVPIEELNISEFKNFCQSIDEDVYEVLNIKNILKSRKTIGAARWEEDV
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DDL_RICM5
Sequence: MHKYQTHWVEHSIVKILSSAGKKYIALMAGGMSAEREVSLVSSEGVSKALIELGYSVTFIDMGADITVRLQEIKPDIVFNCLHGTYGEDGCLPGLLNIMRIPYTHSGMLSSALAFNKIHSRSWFLTNNINMAESIVVNKSDNIKNDPMKRPYVIKPLTQGSSIGVEVIFAEDNFNFADYDFPYGDQVIIEQYIKGRELQVAVLNGKALGVLEIKLLKNRFYDYETKYTEGFADHLCPAPLPANLYEKLLIESEKIYKTMNCKGPARAEFILEEQTNKLYALELNTHPGMTPLSIVPEIAAYAGINFTNLIEEIIKTASFES
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y805_STAAB
Sequence: MNPIVEFCLSNMAKGGDYVFNQLENDPDVDVLEYGCLTHCGICSAGLYALVNGDIVEGDSPEELLQNIYAHIKETWIF
What are the official names of this protein?
UPF0349 protein SAB0805.
What is the protein family that this protein belongs to?
Belongs to the UPF0349 family.
Protein: DUSTY_TAKRU
Sequence: MEGHGPQKSSPLARDLTRAFNGYHKQTVLLKKNLKETHAFFREMRQNYSNTCASSTLSSDSASLETSQFSCISFPSHEEEFLRNTVGAAPYILVLGQDCAARYQLLNCLLGERLLPLGPQAGHACHGGQGSTCKRRKLCFTHGKQTRLSLALPGQYELVHQLVANCGRWDTVPREDLEILDECEDPAHRQAELEITLHHPMLQEAKVMVVPCPSVQPIEEAIEDCTRSAIPIVLYAVNQDSLSSEQVADLWKVKEILSFPICFVRLPNLSEDSSEPGQRFEKDKSKLQKQLLSHGLLTCPMGNCSCGAPTQMPTPGAKPQSVLGENFERLHRILVPFTRQVLQNQQVEAASLLNGLHCRCLDLFINQAFDMQRDLQITPRRLEYTREKEGELFTSLMAIANRKQEEMKDMIVETLGSMKEQLLEDAANLEFTDIIVTTNGDPVTSKEIKSCIHQIQDLIVVRLNQAVANKLISSVDYLRESFVGTLERCLDSLEKSHIESSVHNITSNHLKQLLNAAYHVEVTFHSGSSVTRLFWEQIKQIIHRITFVNPPAITPEWKRKVAQDAIESLSAAKLARSICSQFRTRLNSSHEAFAASLRQLEERHTGRLERTEDLWLRVRKDHAPRLARLSLESRSLRDVLLHGKPKLGRELGRGQYGVVYLCDNWGGHYPCALKSVVPPDDKHWNDLALEFHYTRTLPKHERLVDLHGSVIDHTYAGGSSIAVLLIMERLHRDLYTGLKAGLSLQERLQIALDVVEGIRFLHNQGLLHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYLCAGSVKLPEAFEKCSSKDQLWNNVKKGARPERLPCFDEECWQLMEACWNGDPSQRPLLGIVEPSLQSMMVRLCCGSEQKSSSLEDSS
What is the function of this protein?
May act as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation.  May induce both caspase-dependent apoptosis and caspase-independent cell death.  May play a role in the embryonic development.
What are the official names of this protein?
Dual serine/threonine and tyrosine protein kinase, Dusty protein kinase, Dusty PK, Receptor-interacting serine/threonine-protein kinase 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction.
Protein: ERB1_USTMA
Sequence: MVRPSSSSSASASAARSGAAKRKRNLPTATNPTTRASVAANVKGKGKTKALELDLVVSDDGEEDGELDLESDSGDDDANDDDDNDNEQDDFPEIDLEDSDDDQDVEDEDEPGAQEEVDSDNNKQASTQVHDIQVEEDDSSEEGYNSSDIDNSDFDDDADEGDLAYDSADEDERASAFAARSDASQTSIDEELSRMMSRYSSKPDEHSGSLSATNKLGIPRSQAAQAFDLRVRNPDGSAKGVFKRSEITGEMKRVYPEIDAAYDSDSSTEDPENRIGNVPLEWYDDLPHIGYDINGRKVMKPATKDELDKFLDTVDGDGEAWFSARDKSTGKDVRLSDEELAIIRKLQNAEIPDDAYDPYEDYVDWFTGEDKVMQTALSGRPEPKSRFVPSKWEHKKVMKIVRAIREGRIVPGAAANKDAKPKFYNIWADAHENDTRSPWAVMAAPKLALPGHAESYNPPAEYLFNEQEQKEWQEAEAEDRKQNFLPTKHDSLRRVGAYQNFVQERFERCLDLYLAPRMMRKKLDIHNPENLLPKLPSPKELRPFPITTSVVYVHPDGGRVRCLSVDPTGNWLVTGGDDGRARLWDVAIGRCTASWDVCEGMPKAERSAVHSIAWCPTKNYSLFTAVVHGRVAVIAPPQTQNYAKTSANAISSKSASSSSGATATSTASFLYATSAAATSMPSKPDARSPVAWTRPSEAERRTGVAMHLNITSPSAANLKTVVWHNKGDYFATVCPDSAAGSAGLLIHQLSKHRSQSPFRKASKGSSIQKLVFHPTKPWIFVATQRYIRIYDLMAQSLIKTLQSGFKWISTLDVHPSGDHLMVGSYDKKLAWFDLDLSARPYKVLKYHARAIRSVHFSTSWNLVADASDDGTLQLFYAKVGADYGENLTLVPLKVLRGHEVKNGLGVLDVKWHPNQPWLFSAGADGNALLWTT
What is the function of this protein?
Component of the NOP7 complex, which is required for maturation of the 25S and 5. 8S ribosomal RNAs and formation of the 60S ribosome.
What are the official names of this protein?
Ribosome biogenesis protein ERB1, Eukaryotic ribosome biogenesis protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat BOP1/ERB1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: RS11_BRUAB
Sequence: MAKEATRVRRRERKNISSGVAHVNSTFNNTMITITDAQGNAIAWSSAGAQGFKGSRKSTPFAAQIAAEDCAKKAQEHGMRSLEVEVCGPGSGRESALRALQAAGFVITSIRDVTPIPHNGCRPRKKRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: NUOK_SALTI
Sequence: MIPLTHGLILAAILFVLGLTGLVIRRNLLFMLIGLEIMINASALAFVVAGSYWGQTDGQVMYILAISLAAAEASIGLALLLQLHRRRQNLNIDSVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: FABZ_NEIMF
Sequence: MDVQLPIEAKDIQKLIPHRYPFLQLDRITAFEPMKTLTAIKNVSINEPQFQGHFPDLPVMPGVLIIEAMAQACGTLAILSEGGRKENEFFFFAGIDEARFKRQVIPGDQLVFEVELLTSRRGIGKFNAVAKVDGQVAVEAIIMCAKRVV
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GTR1_SHEEP
Sequence: MEPTSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWMQRYGEPIPPATLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTELRGALGTLHQLGIVVGILIAQVFGLDSIMGNQELWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRDLQEMKEESRQMMREKKVTILELFRSAAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV
What is the function of this protein?
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake.  Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.  Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity).  In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity).
What are the official names of this protein?
Solute carrier family 2, facilitated glucose transporter member 1, Glucose transporter type 1, erythrocyte/brain, GLUT-1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Photoreceptor inner segment.
Protein: RL27_BURO1
Sequence: MAHKKAGGSSRNGRDSESKRLGVKVYGGQAINAGGIIVRQRGTRMHAGENVGMGKDHTLFALVDGHVKFATKGADKKHLVIVVPAAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: FOLD_SYNS3
Sequence: MALRLDGKQLAAQLEVRLQQQIQKGIAAAGRSPGLAVLRIGDDPASAVYVRNKEKACARIGVESFGSHLPADASQQEVLTAIRELNADDRVDGILLQLPLPEGLDETPLLAEIDPNKDADGLHTLNLGRLLKGEQGPRSCTPAGVMVMLRDQGIDPAGKRAVVVGRSILVGQPMALMLQAANATVTVAHSRTQHLESITRQAEILVVAAGRPEMIGADHITPGCVVVDVGIHRRPEGGLCGDVCAEELEPVAAALSPVPGGVGPMTVTMLLVNTVLAWCRRHQVALELSDLVV
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RS6_CHLCV
Sequence: MKEKKAQLYEGAYVFSVTLSEEARRKALEKVTSGITNYGGEILKIHDQGRKKLAYTIRGAREGYYYLIYFTVVPGVIAELWKEYHLNEDLLRFLTLKADAVKEVLEFASLPE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RNFB_THIDA
Sequence: MFTAIWVMVGLAIAIGLILGWSAIRFKVEGNPLAEKIDAILPQTQCGQCGFPGCRPYAEAIAKGEADINQCPPGGEEGVKKLAELLGVEPKPLDEAHGTPKPKSVAFIDEQTCIGCTLCIQACPVDAISGAAKQMHTIIADECTGCELCLAPCPVDCISMVPIAEDLPHWKWKHPVVMMKQVGESTRV
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit B, Rnf electron transport complex subunit B.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane.
Protein: UREA_CRYNB
Sequence: MHLLPRETDKLIVTTLGTLAQRRLARGLILNRAETIALISSQLQEFIRDGRHSVAELMDLGKKMLGRRHVRKGVPESIHTIQVEGTFPDGVFLVTVDDPISSDDGDLNNAFYGSFLPIPSADVFPAAPEPADTLLGALICRKEPIKINASRRRFKLEVKNAGDRPIQVGSHYHFLETNPALIFDRLLSYGYHLDIPAGTAVRFEPGEKKTVTMVEFGGKKIFHGGSGLASGSFDENLRETKVKEMVEKGGFGHKDQEKVEEGPTTEMNREVYASMFGPTTGDKIKLADMDLWIEVEKDYTVYGEECKFGGGKVLRDGGGQASGRHEHEVLDLVITNALIVDWNGIYKADIGVKNGIIVGIGKAGNPDMMDGVTDGMIVGSSTEVIAGEKLIITAGALDVHVHYICPQLMTEALASGITTVVGGGTGPADGSNATTCTSSSFYMQNMIKATDTVPLNFGFTGKGNDSGTNALRDVIEAGACGLKVHEDWGATPEVIDRALSIADEYDVQVNLHSDTLNESGYVESTLAAIKGRTIHSYHTEGAGGGHAPDIIVVCEYENVLPSSTNPTRPYAVNTLDEHLDMLMVCHHLDKSIPEDIAFADSRIRSETVAAEDVLQDTGAISMISSDCQAMGRIGEVITRTWRTAAKMKQFRGPLEGDEPTRDNNRVKRYVAKYTINPAITHGMSHLIGQVAVGCLADLVFWTAESFGARPEMILKGGVIAWAAMGDANASIPTVQPVIGRPMWGSQPEAAALNSIVWVSQASLDKDLVKRFNIKKRAEAVKNCRAIGKKDMKWNDSMPKMTVDPETYDVHADGVLCDVPPADKLPLTKRYFVY
What are the official names of this protein?
Urease, Urea amidohydrolase.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
Protein: GUF1_ARTOC
Sequence: MRGCLQPARWLTTATLRRPLLSCPRQLPTRYNPFPRPFHHAPVLQARQPSKPLSLVEERIDAIPIERYRNFCIVAHVDHGKSTLSDRLLELTGTIKPGENKQVLDKLDVERERGITVKAQTCTMLYNHRGKDYLLHLIDTPGHVDFRTEVSRSYASCGGALLLVDASQGVQAQTVANFYLAFAQGLTLVPVINKVDLPSADPERALEQMKTTFELDVDKAVRVSAKTGLNVQELLPAIIESIPALLLVDSWYSTYKGVIILTRVFDGEVKAGDQLVSFATGLKYTVGEVGIMYPSQTPQSVLRAGQVGYIYFNPGMKRSQEAKIGDTFTKVGCESLVEPLPGFEEPKSMVFVAAYPVDSNDFHHLEESINQLLLNDRSVTMQKESSEALGAGFRLGFLGTLHCSVFEDRLRQEHGASIILTPPTVPCKVIWKDGKETIFTNPSRFPDEDTLRVKVAELQEPYVLATITFPEEYLGRVMELCEANRGEQVSMEFFTATQVILKYQLPLAQLVDDFFGKLKGSTKGYASIDYEESEWRKSNVVKLQLLVNKTPVDAVSRIVHSSQANRLGRQWVTKFKEHVERQMFEVIIQAAVGRNVLARETIKPYRKDVLAKLHASDITRRKKLLEKQKEGRKRLKAVDSAMVAIFLARVPVNNGGSKDLFVWVWMGVWIPRQL
What is the function of this protein?
Promotes mitochondrial protein synthesis.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Binds to mitochondrial ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Translation factor GUF1, mitochondrial, Elongation factor 4 homolog, EF-4, GTPase GUF1, Ribosomal back-translocase.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.