PharMolix/UniProtQA huggingface dataset:
Protein: PROB_STRPC
Sequence: MGMMKRQFEDVTRIVIKIGTSSLVLPTGKINLEKIDQLAFVISSLMNKGKEVILVSSGAMGFGLDILKMEKRPTNLAKQQAVSSVGQVAMMSLYSQIFAHYQTNVSQILLTRDVVVFPESLANVTNAFESLISLGIVPIVNENDAVSVDEMDHATKFGDNDRLSAVVAGITKADLLIMLSDIDGLFDKNPTIYEDAQLRSHVAVITQEIIASAGGAGSKFGTGGMLSKIQSAQMVFENKGQMVLMNGANPRDILRVLEGQPLGTWFKQIEEVTHD
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP39_HUMAN
Sequence: MQNSHMDEYRNSSNGSTGNSSEVVVEHPTDFSTEIMNVTEMEQSPDDSPNVNASTEETEMASAVDLPVTLTETEANFPPEYEKFWKTVENNPQDFTGWVYLLQYVEQENHLMAARKAFDRFFIHYPYCYGYWKKYADLEKRHDNIKPSDEVYRRGLQAIPLSVDLWIHYINFLKETLDPGDPETNNTIRGTFEHAVLAAGTDFRSDRLWEMYINWENEQGNLREVTAIYDRILGIPTQLYSHHFQRFKEHVQNNLPRDLLTGEQFIQLRRELASVNGHSGDDGPPGDDLPSGIEDITDPAKLITEIENMRHRIIEIHQEMFNYNEHEVSKRWTFEEGIKRPYFHVKPLEKAQLKNWKEYLEFEIENGTHERVVVLFERCVISCALYEEFWIKYAKYMENHSIEGVRHVFSRACTIHLPKKPMVHMLWAAFEEQQGNINEARNILKTFEECVLGLAMVRLRRVSLERRHGNLEEAEHLLQDAIKNAKSNNESSFYAVKLARHLFKIQKNLPKSRKVLLEAIERDKENTKLYLNLLEMEYSGDLKQNEENILNCFDKAVHGSLPIKMRITFSQRKVEFLEDFGSDVNKLLNAYDEHQTLLKEQDSLKRKAENGSEEPEEKKAHTEDTTSSSTQMIDGDLQANQAVYNYSAWYQYNYQNPWNYGQYYPPPPT
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-processing factor 39, PRP39 homolog.
What is the protein family that this protein belongs to?
Belongs to the PRP39 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CONN_DROME
Sequence: MATLADSAICFLLLSLLLIGACLVTPTEGRAKDDRRTRGRGSSSGVLSSSSSSSNNMNNGYYSGSSSTAGSSSGYVFTSSSAVNSGSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHCTLQEPKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHKRYDYYDDNNGGMSLGHGLDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDILTTKNAIYIKLFLLKPEMLPCHDELSDPTELPLSRDLMDVRSNVGQDMSTAGANSLAQGMTIIVSLVALMMISRG
What is the function of this protein?
Cell adhesion protein involved in target recognition during neuromuscular development.  Mediates homophilic cellular adhesion.
What are the official names of this protein?
Connectin.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: Y369_PHEZH
Sequence: MKDLNSLMKQAQAMQQKLADAQGRIAEMEVEGTSGGGMVKLVLKGTGELARVDLDESLMAPGEGEVVADLIVAAHADAKRKLDEKQAEVMREAAGPFAGMPGMPKLF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein PHZ_c0369.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: KDSB_RHOBA
Sequence: MKCMIVIPARLASSRLSQKLLLQAGGKSVLQHTYEAALKSSVAEEVIVAVDDPRLAAEVDSFGGQARLTSVDCQSGTDRIAEVALMHEDINILINVQGDEPEIDPKTIDAVAKLLMQHPEADIATAACAIKDRERVEDPNCVKAVLGDDHRAITFSRAAVPHPRDGLTDALLNAEPPNYWQHIGLYAYRREFLLWFATQPPGRLEQIEKLEQLRAIEAGKTIVVAPVEASAPGIDTLEDFRAFTARIESQ
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYL_HAEI8
Sequence: MQEQYRPDMIEPKVQQYWAENKVFKAIKDESKEKYYCLSMFPYPSGRLHMGHVRNYTIGDVISRYQRMLGKNVLQPFGWDAFGLPAEGAAIKNKTAPAKWTYENIAYMKKQLQLLGFGFDWDREIATCKPEYYKWEQWFFTELYKKGLVYKKTSTVNWCPNDETVLANEQVHEGCCWRCDTPVEQKEIPQWFIKITDYAEQLLGGLDALPQWPDMVKTMQRNWIGRSEGVEITFDVANTNEKVAVYTTRPDTFYGVSYLGIAAAHPLASLAAQNNSELAAFIQEAKNAKVAEADLATMEKKGMATGLFAIHPLTGEKLPIWVANFVLMHYGTGAVMAVPAHDQRDFEFAQKYSLQIKQVIEPIADEEIDLTKQAFVEHGKLVNSAEFDGKDFDGAFNGIADKLEKLGVGKRQVNYRLRDWGVSRQRYWGAPIPMLTLENGDVVPAPMEDLPIILPEDVVMDGVKNPIKADPNWAKTTLNGAPALKETDTFDTFMESSWYYARYTCPQYQNGMLDAEEANYWLPVDQYIGGIEHATMHLLYFRFFHKLLRDAGFVTSDEPADKLLCQGMVLADAFYYTSPTNERIWVSPTLVTLERDEKGRIIKATDPEGRELVHSGMTKMSKSKNNGIDPQEMVEKYGADTVRLFMMFASPAEMTLEWQESGVEGAKRFLGRVWNLVYQYQQNPAKTSLDITALSAEQKVLRREVHKTIAKVSDDIGRRQTFNTAIAAVMELMNKLTKASLDSEQDRAVMAEALSAVVRMLYPITPHICFELWQALGNESAIDTAEWVKADEAAMVEDEKLIVVQVNGKVRGKVTVAADADEDTVKTIAFADENVKKFIDNQHIVKVIYVVGKLLNVVVKP
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_PSEPW
Sequence: MVERKASVERNTLETQVKCSINLDGSGKARFDIGVPFLEHMLDQIARHGLIDLDIECKGDLHIDDHHTVEDVGITLGQAFAQAIGDKKGIFRYGHAYVPLDEALSRVVIDFSGRPGLQMHVPYTRATVGGFDVDLFQEFFQGFVNHALVTLHIDNLRGHNTHHQIETVFKAFGRALRMAVTQDERMAGQMPSTKGCL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC11_FUSV7
Sequence: MLSSLGNPRQAAAQLMNFALILSTAFMMWKGLSVITDSPSPIVVVLSGSMEPAFQRGDLLFLWNRNLLRETEVGEVVVYNVKDKDIPIVHRVVRKFGNGDTAELLTKGDNNLSDDTELYAKGQDYLERKDIIGSVVAYMPFVGYVTILLSEHPWLKTVMLGIMGLLVVLQRE
What is the function of this protein?
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).  Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
What are the official names of this protein?
Signal peptidase complex catalytic subunit SEC11, Signal peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26B family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: MDM31_SCHPO
Sequence: MLESRLAKNIARIVQARKPYLISYHVRASTQNALLKQTVLQSSSFKSFPTLPRLAARNISNSGILSRTTPVIIKQISMVRSYSSGDVENPEILNKNESNQSSGVKRAMPFRVLKKMKSFLFKQNKPLTVDNVTAFFSWWLVSHIVWIVVGTTTFFSLLLYTLNTVSAQELLGRWIGQLMTKNTGFQFVFESAIVPNWRKGLITFNKISVIRRPDTLNGIGAQNPNNKSDYEKEYMALRKRYDSNEEPDTEALSQGNYTQFELSIDKADVSFSFARFLNGKGIVKELQLKGVRGVVDRRFIEWDPSSDPRDYRRKHNWGDFEIEKFKLEDLRVTLLQPKGFRKFPVSVFFCELPRLRKQWLFYDLMNAKTLTGSFDNSMFTIHRLQLRPYSPYLKVGKQLDDMRHSRLRIDNVAIDHLNRGVSGAFGWINDGSVDFLVNISFPSEPSENSFQKAWISLMDKLKKKEKDEDVYKDVHFDVNVQLHNPKAVIPIFTNQVSYINNALIRPIIAYINSTRTFIPILCHVSKPLSDFDGSWTFYDSGVLQEISAQVYESFARDVLNQEIRRKRIQKVGYWSLRRFLHLVLVSLQELAPTTSSISNFE
What is the function of this protein?
Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria.  Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures (By similarity).
What are the official names of this protein?
Mitochondrial distribution and morphology protein 31.
What is the protein family that this protein belongs to?
Belongs to the MDM31/MDM32 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: KPRS_CLOAB
Sequence: MINHGKNIKIFTGNSYPSLAEEIADIIGVQVGDSRVGKFSNGETAVDINETVRGTDLFLIQTLCEPVNDSIMELLIMLDAFKRASAGRITAVIPNYAYARQDRKAKARQPITAKLMADLIHTAGADRVLTMDLHAPQIQGFFDIPVDHLEGVPILAKYFINQNSNTDDLIVVSPDIGGVKRTRKFAEKLHAPIAIIDKRRPKPNVSEVMSIIGDVKGKKAILVDDMIDTAGSIVNAAEALVKMGAKEVSACCTHGVLSGPAIERLENSPLKEVVILNTIPIEGDKRIDKIKVLSVAPIFAEAIRRIYEDMPVSKIFQEE
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SICA_SALDU
Sequence: MDYQNNVSEERVAEMIWDAVSEGATLKDVHGIPQDMMDGLYAHAYEFYNQGRLDEAETFFRFLCIYDFYNPDYTMGLAAVCQLKKQFQKACDLYAVAFTLLKNDYRPVFFTGQCQLLMRKAAKARQCFELVNERTEDESLRAKALVYLEALKTAETEQHSEQEKE
What is the function of this protein?
Type III secretion-associated chaperone required for SipB and SipC stabilization.  Prevents premature association of SipB with SipC, which may lead to their targeting for degradation.  Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE (By similarity).
What are the official names of this protein?
Chaperone protein SicA, Salmonella invasin chaperone.
What is the protein family that this protein belongs to?
Belongs to the LcrH/SycD chaperone family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECR_STRMU
Sequence: MLYPTPIAKLIESFTKLPGIGIKTATRLAFYTIGMSDEDVNNFAKNLLAAKRELTYCSVCGNLTDDDPCNICTDESRDRSTVLVVEDSKDVSAMEKIQEYHGLYHVLHGLISPMNGIGPDDINLKSLLTRLRDNSDIHEVIIATNATADGEATAMYISRVLKPAGITVTRLARGLAVGSDIEYADEVTLLRAIENRTEL
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: RUVB_MYCGE
Sequence: MKLQIKPPNTFDEFVGKQEIISQIQLSIKASKLNKTQLDHILLYGPPGVGKTTLARLIANELKTKLQIIQGGHLQKPSDFLNAISLIKKGDVLFIDEIHAVAPNVMELMYPVMDVFKIQVLIGKDFNSKIVEMKVNPFTLIGATTQLGKIINPLEDRFGVILNINYYSNAEIEKMVSIYGKQMKLELNSNEISAITEHSKQTPRIAIRIVRRIFEQKIVNKKIDLEGLFKNLMIYKNGLQSIDVQYLEVLNRQNEPQGIKSISSMLGIDRHTIENKIEPFLLRENMIQKTKKGRIITNSGREYLVNF
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: PSB_MYCVP
Sequence: MTWPNRDQPAFPSSSSGAFSALPQGVSHGGVNLSSFSDFLRHQAPHLLPGAPGPGPTGLPTDAVPHGTTIVALKCPGGVVMAGDRRATQGNMIASRDVQKVYITDDYTVTGIAGTAAIAVEFARLYAVELEHYEKLEGVALTFPGKVNRLATMVRGNLGAALQGFVALPLLAGYDLDDPNPEAAGRIVSFDAAGGWNFEEEGYQSVGSGSIFAKSSMKKLYSQVTDAESALRVAVEALYDAADDDSATGGPDLVRGIFPTAVVIGADGAHEVPEAKISSLCREVVENRSRTETFGPDARPTRGDEL
What is the function of this protein?
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
What are the official names of this protein?
Proteasome subunit beta, 20S proteasome beta subunit, Proteasome core protein PrcB.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS7_DICTD
Sequence: MPRRGPVTPREIPPDPVYNSVLVQKLINKVMLDGKKSIAEKIVYGAMDIIREKTKQDPLTVLEKAVQNVTPLLEVRPRRVGGATYQVPIEVPPRRGLSLALRWIVRAARERKGMPMKERLALEILDAFNNTGGAIKKRDEMHRMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: P85A_PONAB
Sequence: MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQLAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTASVDLEMIDVHVLADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
What is the function of this protein?
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.  Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.  Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB.  Likewise, plays a role in ITGB2 signaling.  Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).
What are the official names of this protein?
Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha.
What is the protein family that this protein belongs to?
Belongs to the PI3K p85 subunit family.
Protein: OBG_LISW6
Sequence: MFVDQVKIYVKAGNGGDGMVAFRREKFVPNGGPAGGDGGKGADVVFVVDEGLRTLVDFRFKRIFKAEHGEHGMSKSMHGRGAEDLVVKVPQGTIVKDIDTGEIIADLVAHGQRAVIAKAGRGGRGNKRFATPANPAPELSENGEPGQERNVQLELKVLADVGLVGFPSVGKSTLLSVVSAARPKIAAYHFTTIVPNLGMVDAGDGRSFVMADLPGLIEGASQGVGLGHQFLRHIERTRVIVHVIDMSGSEGRVPYEDYMAINNELEQYNLRLMERPQIIVANKMDMPEAEENLKEFKTKIAEDIPVFPISAVTKTGLRELLLAIADKLETTPEFPLNEILEQEDEDTVLYKYIAEEPDFEITREPDGTFVLSGTKIERLFTMTNFERDASISRFARQLRAMGVDEALRKRGAKDGDIVRLLDYEFEFMD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF2_RICCK
Sequence: MTDNQEIKPKKLTLGNSKLSLNKSFDSLTGAQSFVNAKSKTLVEVRKSSIGSTTTISLNKERNNLDQTVIDANKEEFNRRLSILKKAAEQSKLNDPSQISTLSKLASINQSTNLKIETLETDKEVAQKRQNITENKVEVSAKIVQGDEDILSQIYKKKAETFVKSPLVGMRTRYSIESEKESDKTAESKVVVQKIKLEEPKKFKKVDLFNMLSDDESGSGRTRTRSLASIKRAREKEKRKLVLQAPEKVYREVTIPEVIGVGDLANAMSERVADVIKELMNLGILANASQVIDADTAELVATNLGHKVKRVQESDVENVLISDDKVEDLRTRAPVVTVMGHVDHGKTSLLDALKSTDIAAGEIGGITQHIGAYRVTLADGRAITFIDTPGHEAFSEMRSRGTKVTDIAIIVVAADDGIKTQTVEAINHAKVAGVPIIIAINKIDKPNIDIERVKNELYIHEIIGEEAGGDVMVIPISALKKINLDKLEEAILLIAEMQDLKASPFGSAAGVVIESKIEKGRGTLTTILVQRGTLKNGDIIIAGTSYGKVKKMTNDKGLEIAEATPSVPVEIQGLNEVPFAGVKFNVVQNEKQAKDIAEYRMRLAKEKKISIAPRSSLEDLFLKASGNSKIKELPLIIKGDVHGSVEAILGSLLKLPSDEIKLRILHSGVGPITESDISLAHASSAIIVGFNVRAGVNALTAAEKAKIDIRYYSIIYNLIDDVKAIMSGMLDPIVREQYIGSVEIRRVFNVTKVGKIAGSYVTKGIIKKGADVRLLRDNIVIHEGKLKTLKRFKDEVKEVREGYECGIAFENYEDIRENDVVEVFELIQEQRQL
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_BUCAI
Sequence: MTEYLFTSESVSEGHPDKIADQISDALLDEILKQDLKARVACETYVKTGMVLIGGEITTTAWVDVEEITRKTINDIGYVNSDAGFDANSCAVLSAIGKQSPDINQGINRFDPLKQGAGDQGIIFGYATNETEFFMPAPITYAHLLMQKQSELRKKNILPWLRPDAKSQVTFKYNNGNIIAIDTVVLSTQHQENITQKYLKEAVMDEIIKPVLPDKWLTKNTKFFINPTGRFVIGGPMGDCGVTGRKIIVDTYGGMSRHGGGAFSGKDPSKVDRSAAYAARYVAKNIVASGLAARCEIQLSYAIGIAEPISIMIDTFNTGKISNSALISLVRSIFDLRPYGLIKMLNLLQPIYLKTAVYGHFGRKEFPWENLDKVNELS
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_HELPY
Sequence: MARKTPLNRIRNIGIAAHIDAGKTTTSERILFYTGVSHKIGEVHDGAATMDWMEQEKERGITITSAATTCFWKDHQINLIDTPGHVDFTIEVERSMRVLDGAVSVFCSVGGVQPQSETVWRQANKYGVPRIVFVNKMDRIGANFYNVENQIKLRLKANPVPINIPIGAEDTFIGVIDLVQMKAIVWNNETMGAKYDVEEIPSDLLEKAKEYREKLVEAVAEQDEALMEKYLGGEELSIEEIKKGIKAGCLNMSLVPMLCGSSFKNKGVQTLLDAVIDYLPAPTEVVDIKGIDPKTEEEVFVKSSDDGEFAGLAFKIMTDPFVGQLTFVRVYRGKLESGSYVYNSTKDKKERVGRLLKMHSNKREDIKEVYAGEICAFVGLKDTLTGDTLCDEKNAVVLERMEFPEPVIHIAVEPKTKADQEKMGVALGKLAEEDPSFRVMTQEETGQTLIGGMGELHLEIIVDRLKREFKVEAEIGQPQVAFRETIRSSVSKEHKYAKQSGGRGQYGHVFIKLEPKEPGSGYEFVNEISGGVIPKEYIPAVDKGIQEAMQNGVLAGYPVVDFKVTLYDGSYHDVDSSEMAFKIAGSMAFKEASRAANPVLLEPMMKVEVEVPEEYMGDVIGDLNRRRGQINSMDDRLGLKIVNAFVPLVEMFGYSTDLRSATQGRGTYSMEFDHYGEVPSNIAKEIVEKRKG
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: STAT6_MOUSE
Sequence: MSLWGLISKMSPEKLQRLYVDFPQRLRHLLADWLESQPWEFLVGSDAFCYNMASALLSATVQRLQATAGEQGKGNSILPHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFRHLPGPFHRKQEELKFTTALGRLQHRVRETRLLRESLQQGAKTGQVSLQNLIDPPVNGPGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPMVRADMVTEKQARELSLAQGPGTGVESTGEIMNNTVPLENSIPSNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFTLGPNKLLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSVEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVPPYDLGMAPDASMQLSSDMGYPPQSIHSFQSLEESMSVLPSFQEPHLQMPPNMSQITMPFDQPHPQGLLQCQSQEHAVSSPEPMLCSDVTMVEDSCLTQPVGGFPQGTWVSEDMYPPLMPPTEQDLTKLLLENQGEAGGSLGSQPLLQPSPYGQSGISLSHLDLRTNPSW
What is the function of this protein?
Carries out a dual function: signal transduction and activation of transcription.  Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
What are the official names of this protein?
Signal transducer and transcription activator 6.
What is the protein family that this protein belongs to?
Belongs to the transcription factor STAT family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Protein: ERG8_CANAL
Sequence: MSKAFSAPGKAFLAGGYLVLEPIYDAYVTALSSRMHAVITPKGTSLKESRIKISSPQFANGEWEYHISSNTEKPKEVQSRINPFLEATIFIVLAYIQPTEAFDLEIIIYSDPGYHSQEDTETKTSSNGEKTFLYHSRAITEVEKTGLGSSAGLVSVVATSLLSHFIPNVISTNKDILHNVAQIAHCYAQKKIGSGFDVATAIYGSIVYRRFQPALINDVFQVLESDPEKFPTELKKLIASNWEFKHERCTLPHGIKLLMGDVKGGSETPKLVSRVLQWKKEKPEESSVVYDQLNSANLQFMKELREMREKYDSDPETYIKELDHSIEPLTVAIKNIRKGLQALTQKSEVPIEPDVQTQLLDRCQEIPGCVGGVVPGAGGYDAIAVLVLENQVGNFKQKTLENPDYFHNVYWVDLEEQTEGVLEEKPEDYIGL
What is the function of this protein?
Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (PubMed:11243736).  ERG8 converts 5-phosphomevalonate to 5-diphosphomevalonate (By similarity).  The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.  Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate.  5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8.  The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate.  The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).  Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
What are the official names of this protein?
Phosphomevalonate kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.