PharMolix/UniProtQA huggingface dataset:
Protein: NAR1_ENCCU
Sequence: MSFFADLPKDNKKCIKIGSPLALSLSDCLACSGCVSADEAGALSEDLSFVLDLSPQTSFVLSPQSKINIFNLYREDGMEYREFEAVLSSFLRSKFNIHRIVDTSYLRSKIYEETYREYMATNHLIVSACPGVVTYIERTAPYLIGYLSRVKSPQQMAFSLVKGSRTVSVMPCQDKKLENGRDGVKFDFILTTRGFCKALDSLGFRRPARASGKSLCSMEEAETTQWNIGTSSGGYAEFILGKHCVVETREIRNGIKEHLLDDGRTISQITGLENSINYFKSSKTKGPRHKMTEIFLCKNGCIGGPGQERVNDVEMDIREYDRNGREQPRIFYSSPGLEEKRVFREVKAKRVDLRVDW
What is the function of this protein?
Component of the cytosolic Fe/S protein assembly machinery.  May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).
What are the official names of this protein?
Cytosolic Fe-S cluster assembly factor NAR1, Nuclear architecture-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the NARF family.
Protein: H2B_PENVA
Sequence: TSGKAAKKAGKAQKSITKGDKKKRKESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
What is the function of this protein?
A mixture of histones H2B and H4 has antimicrobial activity against the Gram-positive bacterium M. luteus.
What are the official names of this protein?
Histone H2B.
What is the protein family that this protein belongs to?
Belongs to the histone H2B family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: YIDE_ECOLI
Sequence: MSDIALTVSILALVAVVGLFIGNVKFRGIGLGIGGVLFGGIIVGHFVSQAGMTLSSDMLHVIQEFGLILFVYTIGIQVGPGFFASLRVSGLRLNLFAVLIVIIGGLVTAILHKLFDIPLPVVLGIFSGAVTNTPALGAGQQILRDLGTPMEMVDQMGMSYAMAYPFGICGILFTMWMLRVIFRVNVETEAQQHESSRTNGGALIKTINIRVENPNLHDLAIKDVPILNGDKIICSRLKREETLKVPSPDTIIQLGDLLHLVGQPADLHNAQLVIGQEVDTSLSTKGTDLRVERVVVTNENVLGKRIRDLHFKERYDVVISRLNRAGVELVASGDISLQFGDILNLVGRPSAIDAVANVLGNAQQKLQQVQMLPVFIGIGLGVLLGSIPVFVPGFPAALKLGLAGGPLIMALILGRIGSIGKLYWFMPPSANLALRELGIVLFLSVVGLKSGGDFVNTLVNGEGLSWIGYGALITAVPLITVGILARMLAKMNYLTMCGMLAGSMTDPPALAFANNLHPTSGAAALSYATVYPLVMFLRIITPQLLAVLFWSIG
What are the official names of this protein?
Putative transport protein YidE.
What is the protein family that this protein belongs to?
Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SCN3A_HUMAN
Sequence: MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKEQDNDDENKPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNMTTGNMFDISDVNNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEKTDGSSSTTSPPSYDSVTKPDKEKFEKDKPEKESKGKEVRENQK
What is the function of this protein?
Mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:24157691, PubMed:28235671, PubMed:29466837).  May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity).  In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity).
What are the official names of this protein?
Sodium channel protein type 3 subunit alpha, Sodium channel protein brain III subunit alpha, Sodium channel protein type III subunit alpha, Voltage-gated sodium channel subtype III, Voltage-gated sodium channel subunit alpha Nav1.3.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.3/SCN3A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YFCN_SALEP
Sequence: MKKKTSLSEEDQALFRQLMVGTRKIKQDTIVHRPLRKKITEVPTRRLIQEQADASHYFSDEFQPLLNTEGPVKYVREDVSHFELKKMRRGDYSPELFLDLHGLTQLQAKQELGALIAACRREHIFCACVMHGHGKHILKQQTPLWLAQHPHVMAFHQAPKEYGGDAALLVLIEVEEWQPPELP
What are the official names of this protein?
UPF0115 protein YfcN.
What is the protein family that this protein belongs to?
Belongs to the UPF0115 family.
Protein: F16PC_STAA3
Sequence: MTQITEKELKKKYLDLLSQNFDTPEKLATEIINLESILELPKGTEHFVSDLHGEYEAFQHVLRNGSGNVRAKINDIFKERLSTKELNDLTALVYYPEDKLKLIKSDFQNCGQLNVWYITTIEHLIELIKYCSSKYTRSKLRKALPKQYVYIIEELLYKSNEYQNKKSYYETLVNQVIELKQADDLIIGLAYSVQRLVVDHLHVVGDIYDRGPQPDKIMDTLINYHSLDIQWGNHDVLWVGAYAGSKVCLANLLRICARYDNLDIIEDAYGINLRPLLTLAEKYYDADNPAFKPKKRPDKHERLTQREESQITKIHQAIAMIQFKLEIPIIKRRPNFEMEERLVLEKVNYDTNEITVYGNTYPLKDTCFQTVNRDNPAELLPEEEEVMNKLLLSFQQSEKLRRHMSFLMRKGSLYLPYNGNLLIHGCIPVDENGEMESFEIDGHTYSGQELLDVFEYHVRKSFDEKENTDDLSTDLVWYLWTGKYSSLFGKRAMTTFERYFIADKASHKEEKNPYYHLREDVNMVRKMLSDFGLNPDEGRIINGHTPVKEINGEDPIKADGKMLVIDGGFSKAYQSTTGIAGYTLLYNSFGMQLVAHQQFNAKEKILSEGIDELSIKRVVDKELQRKKIRDTNIGKDLQAQIDILKMLMHDRYLD
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 3, FBPase class 3, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 3 family.
Protein: SELT_MOUSE
Sequence: MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS
What is the function of this protein?
Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity).  Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473).  Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity).  Plays a role in fibroblast anchorage and redox regulation (PubMed:19935881).  In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity).  In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (PubMed:23913443).
What are the official names of this protein?
Thioredoxin reductase-like selenoprotein T, SelT.
What is the protein family that this protein belongs to?
Belongs to the SelWTH family. Selenoprotein T subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: CORA_YERPE
Sequence: MLSAFKLHNNRLSRLELDESDDLASSLWVDLVEPEEGERERVQTELGQSLATRPELDDIEASARFFEDEDGLHIHSFFYYEDADDHAGNSTVAFTIRDGRLYTLRERELPAFRLYRMRARNQTLVDGNAYELLLDLFETKIEQLADEIENIYSDLEALSRVIMEGQQGDEYDAALSTLAEQEDIGWKVRLCLMDTQRALNFLVRKARLPSSQLEQAREVLRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELRWSFGYPGAIALMIIAGLAPYLYFKRKNWL
What is the function of this protein?
Mediates influx of magnesium ions (By similarity).  Alternates between open and closed states.  Activated by low cytoplasmic Mg(2+) levels.  Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
What are the official names of this protein?
Magnesium transport protein CorA.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RK2_MARPO
Sequence: MAIRLYRAYTPGTRNRSVPKFDEIVKCQPQKKLTYNKHIKKGRNNRGIITSQHRGGGHKRLYRKIDFQRNKKYITGKIKTIEYDPNRNTYICLINYEDGEKRYILYPRGIKLDDTIISSEEAPILIGNTLPLTNMPLGTAIHNIEITPGKGGQLVRAAGTVAKIIAKEGQLVTLRLPSGEIRLISQKCLATIGQIGNVDVNNLRIGKAGSKRWLGKRPKVRGVVMNPIDHPHGGGEGRAPIGRKKPLTPWGHPALGKRSRKNNKYSDTLILRRRKNS
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL6_SHEPW
Sequence: MSRVAKAPVAIPAGVEVTLNEQTITVKGTKGSLTRVINADVSVVVEDNEIKCSSVEGVKTAAQAGTARALINNMVVGVTAGFEKKLQLIGVGYRAKIAGKGVDLTLGFSHPLVHELPDGVTAECPSQTEIVLKGTDKQLIGQVAAEIRGYRPPEPYKGKGVRYADEQVRRKEAKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: KT5AB_XENLA
Sequence: MGRGKKMSKPGDGRSGDVPETCRTGGTNENHPKMNGEVVHLGQPKIYSYMSPTKSPSGRPPLQEENSVAHHESKNLGKPTTETRKKAEVEKKRISSATELSVKSSKQRETECNSIGEYFQTKQELTDVQRNTALTPVDKLQSQKMVKNKSQRRKAQRKKSPNRKLTDYYPVRRSCRKSKTELESEEKMRIDELIQTGKEDGMKMDMIIGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYFQYLNKTYCIDATRETGRLGRLINHSKSGNCHTKLHNISNVPHLILVASRDILVGEELLYDYGDRRKSSIEAHPWLKN
What is the function of this protein?
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins.  Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1).  H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.  Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.  Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis.  Involved in chromosome condensation and proper cytokinesis.
What are the official names of this protein?
N-lysine methyltransferase KMT5A-B, Histone-lysine N-methyltransferase KMT5A-B, Lysine-specific methylase 5A-B, Mitotic phosphoprotein 36, SET domain-containing protein 8-B.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms (By similarity).
Protein: PDHS_BRUAB
Sequence: MSGSYPFIDIAALDSVREGFARGDAQLVLAHDLSTVLWVNGPGAKLFGYNRVEDLIEGQLDLPVATRRQIAAFSSENTSAPSAVAVRLGGGLRSELTHLHVSNIKLPDGVAALLVATQMPDNSAEAAISGLGDDSTHIALVDAVGKVVAASPRFALLDISASTLEDLIVEAGDATDRIVKRRIRTGSHSVPGAIARLTDTPALHLLCIVGDAPAQFQTAAEAVPLPDNAEAVLEEILPEQGDAPAQQAQKTHAEQPRPKTFAFDHDAPPARFIWKVGPDGTFSEISPNLAAVVGPNSADIVGRRFSDVANVFGFDTDGSIAALLLERDTWSGKRLLWPVEGTRLRVPVELAALPVYSRDREFLGFRGFGIVRPAEAEADPEEIGLALAGGIPQNRKPRKEPAETARMVGEDDVLALSEEVANDDQPAAVLPKPPLDITPTPGRRDSDKVISLLNSCAQEKVAADQAKFLKEKERATRPEGGLTKTERNAFREIAERLRKQGLANTRAESETPVSETSSIEPVEPTPPVKTRSEPIQPDETALLANLPVPVIIHSGDAIHYVNQALLDITGYESLDDIRSAGGVDVLFNSESDDGETRQSMLLRHADGSEEPVDAHLNAIAWRGGRALMLSLMPVTAADLPAPAELPAANDEEKQALEAHVEELKTILDTATDGVVLIDPEGRIRSMNHSASALFGYERDEAEGKFFSMLFAIESQRAAMDYLHGLSGNGVLSVLNDGREVIGREAKGGFIPLFMTIGKLPHTRGFCAVLRDITQWKRTEEELTNARKEAERASNQKTEFLARISHEIRTPLNAIIGFSELMADEKFGPIGNDRYRDYLRDINRSGNHVLALVNDLLDISKIEAGALDMQFEAVSLNDAIGEAIALMQPQANRERVIIRSSFQSNLPDIVADSRSIKQVALNLLSNAVRFTAPGGQVIVSTSYELNGDVVMRVRDTGIGMSKSEVEQALKPFRQINALERRKAESAKDWRNEGTGLGLPLTKAMVEANRAQFAIDSNPGQGTVVEIVFPPTRVLAD
What is the function of this protein?
Functions as a polar differentiation marker.  Essential protein that, by localizing in the old pole of dividing cells, controls cell division and maturation, probably through control of DivK phosphorylation status and cellular distribution, which in turn regulates CtrA, a transcriptional regulator of the minB operon.  The asymmetrical localization of this protein is probably required for cells to enter a new division cycle.
What are the official names of this protein?
Cell-division control histidine kinase PdhS, PleC-DivJ homolog sensor.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at the old pole of dividing cells. Colocalizes with DivK.
Protein: PCOA_ECOLX
Sequence: MLLKTSRRTFLKGLTLSGVAGSLGVWSFNARSSLSLPVAASLQGTQFDLTIGETAVNITGSERQAKTINGGLPGPVLRWKEGDTITLKVKNRLNEQTSIHWHGIILPANMDGVPGLSFMGIEPDDTYVYTFKVKQNGTYWYHSHSGLQEQEGVYGAIIIDAREPEPFAYDREHVVMLSDWTDENPHSLLKKLKKQSDYYNFNKPTVGSFFRDVNTRGLSATIADRKMWAEMKMNPTDLADVSGYTYTYLMNGQAPLKNWTGLFRPGEKIRLRFINGSAMTYFDIRIPGLKMTVVAADGQYVNPVTVDEFRIAVAETYDVIVEPQGEAYTIFAQSMDRTGYARGTLATREGLSAAVPPLDPRPLLTMEDMGMGGMGHDMAGMDHSQMGGMDNSGEMMSMDGADLPDSGTSSAPMDHSSMAGMDHSRMAGMPGMQSHPASETDNPLVDMQAMSVSPKLNDPGIGLRNNGRKVLTYADLKSRFEDPDGREPGRTIELHLTGHMEKFAWSFNGIKFSDAAPVLLKYGERLRITLINDTMMTHPIHLHGMWSDLEDENGNFMVRKHTIDVPPGTKRSYRVTADALGRWAYHCHLLYHMEMGMFREVRVEE
What is the function of this protein?
Required for the copper-inducible expression of copper resistance.  May have oxidase activity (By similarity).
What are the official names of this protein?
Copper resistance protein A.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family. CopA subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: THIG_PROM5
Sequence: MKEDSALIIGGKNFSSRLMVGTGKYTSAEVMVESLLNTESEIVTVAVRRVQNHQNGENLLEKIDWEKFWMLPNTAGCANADEAVRIAILGRELAKLSGQEENNFVKLEVIPDKKYLLPDPIETLKAAEILIKKDFIVLPYINADPILAKKLEEIGCSTVMPLGSPIGSGQGLLNLSNISIIIENSNIPVIIDAGIGVPSEASQAMELGADGVLINSAIALAKDPLKMAKAMNHGVRAGREAFLAGRIEKQRLASASSPFTNISKK
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2350_VIBVY
Sequence: MAQFIDRRLNGKNKSAVNRQRFMRRYKEQIKESVADAVNRRSITNTETGEDVAIPHKDIKEPLFHQGKGGLRERVHPGNDQFITGDKIERPKGGQGGGGAGDGDASADGEGQDDFVFQISKDEYLDLLFEDLALPNLKKNQVNKITEWKKHRAGYQTAGMPSNISIVRSLQQSLARRTAMSAGKKRLLHELELELERIQNQEPAQKLEEMKLKQEIAELRKAIESVPFIDTFDLRFKNYERKPVPSSQAVMFCLMDVSGSMDQATKDIAKRFYVLLYLFLNRTYENVEVVFIRHHTQAKEVDEHEFFYSQETGGTIVSSALKLMDEIVKARYPVGEWNIYAAQASDGDNWADDSPRCKELLTNKLLPNCQYYAYIEITRRSHQTLWHEYEKLEESFDNFAMKNIRSVEDIFPVFRELFHKETA
What are the official names of this protein?
UPF0229 protein VV2350.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: RAB7L_HUMAN
Sequence: MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDYEIVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPNGEPVPCLLLANKCDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLIEKMMRNSTEDIMSLSTQGDYINLQTKSSSWSCC
What is the function of this protein?
The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816).  Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity).  Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816).  Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815).  Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity).  May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S. Typhi) epithelial cell infection (PubMed:22042847).
What are the official names of this protein?
Ras-related protein Rab-7L1, Rab-7-like protein 1, Ras-related protein Rab-29.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:29212815). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847). Colocalizes with TGN46 at the trans- Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847).
Protein: LCRV_YERPG
Sequence: MIRAYEQNPQHFIEDLENVRVEQLTGHGSSVLEELVQLVKDKNIDISIKYDPRKDSEVFANRVITDDIELLRKILAYFLPEDAILKGGHYDNQLQNGIKRVKEFLESSPNTQWELRAFMAVMHFSLTADRIDDDILKVIVDSMNHHGDARSKLREELAELTAELKIYSVIQAEINKHLSSSGTINIHDKSINLMDKNLYGYTDEEIFKASAEYKILEKMPQTTIQVDGSEKKIVSIKDFLGSENKRTGALGNLKNSYSYNKDNNELSHFATTSSDKSRPLNDLVSQKTTQLSDITSRFNSAIEALNRFIQKYDSVMQRLLDDTSGK
What is the function of this protein?
Possibly involved in calcium regulation of YOP expression, which includes the export process.
What are the official names of this protein?
Virulence-associated V antigen, Low calcium response locus protein V.
What are the subcellular locations of this protein?
Secreted.
Protein: EFTS_METI4
Sequence: MANSLSVHLVKELREKTGAAIMDCKKALEVSKGDIDEAEKWLRQQGIAKAKKKSERLTPEGVIASYIHAGDKIGVLVEVNCETDFVARTPTFKELAKEVAIQIAAASPRFLSKEDIPKEVLDEERQKIIESLKGQNKEDLDKVVQEKLEKFIVDSCLLEQPFVKDQSITVRDLICQRIAQIGENIVVRRFVRFQLGEEIEN
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1902_EXIS2
Sequence: MTLDKTNRMNYLIDFYQELLTPKQRNYMSLYYLDDFSLGEIADEFEVSRQAVYDNIKRTEAMLEQYEERLGLFAKYEQRKLLLDQLKQLDLPSEAHVTIAALEQLE
What is the function of this protein?
Might take part in the signal recognition particle (SRP) pathway.  This is inferred from the conservation of its genetic proximity to ftsY/ffh.  May be a regulatory protein.
What are the official names of this protein?
UPF0122 protein Exig_1902.
What is the protein family that this protein belongs to?
Belongs to the UPF0122 family.
Protein: DISA_CORGL
Sequence: MTPTTTPVSNPDALSTGTQDVHTLKGTLQRLAPGTPLRDGLDRIVRGHTGALIVIGDDENVSSICDGGFEFDVSFAATRLRELCKMDGAVILSSDLERIKRANVQLLPSPTWPTQESGTRHRSAERTALHTGVPVIAVSESQNTITLYVEGKSHMLEQPAALLNRANQALGTMERYRDRLDQVNNRLHLAELHSYVTVIDVVSVIQREEMLRRVGEIIDGDVLELGKDAKEIQIQLSELRGDNDRERESIIADYLVTDGIPADEEIHAALEAISHLDDKALLNPANIARVLGLPPTEEALDEPVTPRGYRTLNRIPRVQKFLMDKLIVEFGNLDALLNASVEDLSAVDGVGSLWARHITDGLGRLS
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP).  c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: THIE_ALKMQ
Sequence: MSPIVKTDYSLYLVTDRSLLNGKDLMESIEAAIKGGVSIVQLREKQATSAVFYETALALKKLTDQYQIPLIINDRLDIALAVDAAGLHIGPDDLPIKKARELLGPHKTLGYSAATLAEALEAESLGANYLGVGALFPTKTKKDTESVSLQLLQKIKSSVSIPIVGIGGISQGNASQVIQSGADGIAVVSAILSKQYPEIAAKNLYLKTQNK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RBOHI_ARATH
Sequence: MSMSFSGGTHNDRWGSDLASAGEFTQSFPSLPATYSPSPSSSSSSGEELLEVTIEFPSGVIINIDSVTGTGTDISGTDLEITSCSDSGSGSRSLSLGWSASSERLTAGTNSKQQIQKISRRGYGYSSRSAPEPVVPHRGEITDSVNLPRALSQRPTRPNRDGSGTERAIHGLKFISSKENGIVDWNDVQNNFAHLSKDGYLFKSDFAHCIGLENENSKEFADELFDALCRRRRIMVDKINLQELYEFWYQITDESFDSRLQIFFNMVKNGDGRITENEVKEIIILSASANNLSRLRERAEEYAALIMEELAPDGLYSQYIELKDLEILLLEKDISHSYSLPFSQTSRALSQNLKDRRWRMSRNLLYSLQDNWKRIWVLTLWFVIMAWLFMWKCYQYKHKDAFHVMGYCLVMAKGAAETLKFNMALILLPVCRNTITYLRSTALSHSVPFDDCINFHKTISVAIISAMLLHATSHLACDFPRILASTDTDYKRYLVKYFGVTRPTYFGLVNTPVGITGIIMVAFMLIAFTLASRRCRRNLTKLPKPFDKLTGYNAFWYSHHLLLTVYVLLVIHGVSLYLEHKWYRKTVWMYLAVPVLLYVGERIFRFFRSRLYTVEICKVVIYPGNVVVLRMSKPTSFDYKSGQYVFVQCPSVSKFEWHPFSITSSPGDDYLSIHIRQRGDWTEGIKKAFSVVCHAPEAGKSGLLRADVPNQRSFPELLIDGPYGAPAQDHWKYDVVLLVGLGIGATPFVSILRDLLNNIIKQQEQAECISGSCSNSNISSDHSFSCLNSEAASRIPQTQRKTLNTKNAYFYWVTREQGSFDWFKEIMNEIADSDRKGVIEMHNYLTSVYEEGDTRSNLLTMIQTLNHAKNGVDIFSGTKVRTHFGRPKWKKVLSKISTKHRNARIGVFYCGVPSLGKELSTLCHEFNQTGITRFDFHKEQF
What is the function of this protein?
Calcium-dependent NADPH oxidase that generates superoxide.
What are the official names of this protein?
Probable respiratory burst oxidase homolog protein I, NADPH oxidase RBOHI, AtRBOHI.
What is the protein family that this protein belongs to?
Belongs to the RBOH (TC 5.B.1.3) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL3_SHEB9
Sequence: MAIGLIGRKVGMTRIFTEDGVSIPVTVIEVAGNRVTQVKTLETDGYRALQVTTGTKKANRITKPEAGHFAKSGVEAGRGLWEMRLVDGEGEGIEVGAELNVDIFADVAKVDVTGQSKGKGFQGGVKRWNFRTQDMTHGNSLSHRSNGSIGQNQTPGRVFKGKKMSGHMGAERVTTQNLVVVRVDVERNLLLVRGAVPGATNGDLIIKPAVKA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: KTHY_THEM4
Sequence: MFIAFEGIDGSGKSTQLVLLEKYLINRGKKVIKVREPGGTILGEKIRDLLLNFNMNKRSELLLFLASRAQLVEEVIRPSIEKGYFVLADRFSDSSIAYQGGARNLGKDLVEKLNIFATNGIFPDIVFFIDIPVQMAVRRMKEKEKDRIEKEGEDFLEKVRTTYLHIAKSRKNFFVIDGTKDVDYVFSQIKRIIDTMLDH
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.