PharMolix/UniProtQA huggingface dataset:
Protein: ATPD_HUMAN
Sequence: MLPAALLRRPGLGRLVRHARAYAEAAAAPAAASGPNQMSFTFASPTQVFFNGANVRQVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSIAVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQAELVGTADEATRAEIQIRIEANEALVKALE
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:29478781).  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element.  Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (PubMed:1531933).
What are the official names of this protein?
ATP synthase subunit delta, mitochondrial, ATP synthase F1 subunit delta, F-ATPase delta subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: DCUP_PSESM
Sequence: MTALKNDRFLRALLKQPVDVTPVWMMRQAGRYLPEYRASRASAGDFMSLCKNPQFACEVTLQPLDRYPLDAAILFSDILTIPDAMGLGLYFETGEGPRFKKTVSTLADIEALPIPDAQQDLGYVMDAVSTIRRELNGRVPLIGFAGSPWTLATYMVEGGSSKDFRKSKAMLYDNPQAMHLLLDKLAQSVTSYLNGQILAGAQAVQIFDSWGGSLSSAAYQEFSLAYMRKIVNGLIRENDGRKVPVIVFTKGGGLWLESIAEIGADTLGLDWTCDIGEARQRVGNKVSLQGNMDPTVLYARPEAIRQEVARILASYGSGTGHVFNLGHGITPEVDPANAGAFINAVHELSAQYHQ
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRSA_CLOPS
Sequence: MVSVKKIVASALVGVLMFSAVGCNMVEKTQAAIDKTTVATVNGEKITLGEVDSHLKGVFTQMKSQYGDKYMDDPQVAQQILQQRQGILNSLVEEKILVVEANKENIVPSEEELNKKIEQQIKLYKEQYGEEGYKKAVESMGYNEDTFKEYLKNQFIADAAASNASKDIKVTDEEAQKYYDENKKQFEVQAKGVLARHLLFENEEEAQKAYDEIQSGKTTFNDLFTKYENNKLEKKTPIAESFVVPDENAQVAKEFVEGLKSLKEGEISKPIKTQFGYHIIQAGATYEKGAQLPFNEVKSQIIQILKQQKDSQKLKSDMDQWKKDLNVKVYDDKLQEGLKISK
What is the function of this protein?
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
What are the official names of this protein?
Foldase protein PrsA.
What is the protein family that this protein belongs to?
Belongs to the PrsA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: MYOD1_ONCMY
Sequence: MELPDIPFPITSPDDFYDDPCFNTSDMHFFEDLDPRLVHVGLLKPDDHHHKEDEHIRAPSGHHQAGRCLLWACKACKRKTTNADRRKAATMRERRRLSKVNDAFETLKRCTSTNPNQRLPKVDILRNAISYIESLQGLLRGAGQEGNYYPVMDHYSGDSDASSPRSNCSDGMMDFNGQSCPPRRRNKYDSTYFNEAPNDSRHKKNSVISSLDCLSNIVERITTDTSACPAVQDGSEGSSPCSPGDGSIASENGAPIPSPINCVPALHDPNTIYQVL
What is the function of this protein?
May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
What are the official names of this protein?
Myoblast determination protein 1 homolog 1, Myogenic factor 1-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RECF_STRPZ
Sequence: MWIKELELKHYRNYDHLLASFSSGLNVFIGNNAQGKTNFLEAIYFLSLTRSHRTRADKELIHFDHSTVSLTGKIQRISGTVDLEINLSDKGRVTKINALKQAKLSDYIGTMMVVLFAPEDLQLVKGAPSLRRKFIDIDLGQIKPVYLSELSHYNHVLKQRNSYLKSAQQIDAAFLAVLDEQLASYGARVMEHRIDFINALEKEANTHHQAISNGLESLSLSYQSSVVFDKKTNIYQQFLHQLEKNHQKDFFRKNTSVGPHRDDLAFYINGMNANFASQGQHRSLILSLKMAEVSLMKALTGDNPILLLDDVMSELDNTRQTKLLETVIKENVQTFITTTSLDHLSQLPEGIRIFHVTKGTVQIDSDIH
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRO_ADEBA
Sequence: MGTSEEELKHIVIDLGCGPFFLGINDKHFPGFLNKQSNACAIVNTASRETGGVHWIAMGWHPPSNFYLFDPFGFSDKKLLQIYQFEYNALLKRSAITSSPDRCVQLFQNNESVQSPHSAACGLYCCMFLHAFANWPAHPFDNPTMDQLVGVPNNMLEAPRAQSIFKQNQETLYSFLHYNSSFFRRYENKLRKQTDP
What is the function of this protein?
Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions.  Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors.  Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating.  Without maturation, the particle lacks infectivity and is unable to uncoat.  Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction.  Cleaves host cell cytoskeletal keratins K7 and K18.
What are the official names of this protein?
Protease, Adenain, Adenovirus protease, AVP, Adenovirus proteinase, Endoprotease.
What is the protein family that this protein belongs to?
Belongs to the peptidase C5 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=Present in about 10 copies per virion.
Protein: Y1958_HAEI8
Sequence: MFSLKRQQGASFEHQARLFLESKGLTFIAANQNFKCGELDLIMNDKETIVFVEVRQRSHSAYGSAIESVDWRKQQKWLDAANLWLAKQNMSLEDANCRFDLIAFGKTPQDIQWIPNFLD
What are the official names of this protein?
UPF0102 protein NTHI1958.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: PRMA_SHISS
Sequence: MPWIQLKLNTTGANAEDLSDALMEAGAVSITFQDTHDTPVFEPLPGETRLWGDTDVIGLFDAETDMNDVVAILENHPLLGAGFAHKIEQLEDKDWEREWMDNFHPMRFGERLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTSLCLQWLDSLDLTGKIVIDFGCGSGILAIAALKLGAAKAIGIDIDPQAIQASRDNAERNGVSDRLELYLPKDQPEEMKADVVVANILAGPLRELAPLISVLPVSGGLLGLSGILASQAESVCEAYVDSFALDPVVEKEEWCRITGRKN
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_RHOCS
Sequence: MPIAPDRVRHPEKANRPDNPIQRKPEWLRVKAPTSPEYGETRSLMRGLRLNTVCEEAACPNIGECWKKKHATFMILGAVCTRACAFCNVATGRPDQLDPHEPEKVAEAVAHLKLEHIVVTSVDRDDLEDGGAGHFARTIRAIRAAAPGTTIEVLTPDFMKKKGAVETVVEARPDVFNHNLETAPRLYPTIRPGARYFTSLQLLARVKEIDPSMFTKSGIMVGLGETKEEVFQVMDDLRAADVDFMTIGQYLAPTPKHAKVDRFVTPDEFAGYVTVGRGKGFLMVASSPLTRSSYHAGADFERLRAAREAKLAGRPVAAPEATSAE
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CORT_DROME
Sequence: MFVEMSVCDSPNKNSKLDKKSLTPFKKVRRKNWKQEAAYKSDTSKGQEVSYVGERFIPNRFERENIEFNLKYIGKRKERDILETGVTLTASYWRQSGFISNINRTFGIGERRLFQFSSQQGTRSRVVDNDSADSDWPCNPRARPYAIQNATHEMPGICSPVDYNMMDWSSGGMVAMSSGQDVMLWRNLDESTMVFSVESPTSLKYSPDGKHLAIGCMDRNYPVLDLWEVRSPTEFLVSYRKLFFKSMGYISCIEWSHDGKEVICGTQCGVIIVLAMPTLNTLMQLREHRHTVKKMKFAPTHKYFASSDTDGKIFIFDAVLKVRLLKLDGRSIVFDWHPWTGEDLAVAERSPASIFIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILVLASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFFPTYKREAILRKQEQKAKDKCSSLSLYKGIR
What is the function of this protein?
Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17251266, PubMed:18020708).  Required for the completion of meiosis in oocytes (PubMed:11252055, PubMed:10683177, PubMed:10924478, PubMed:17251266, PubMed:18020708).  Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis (PubMed:17251266, PubMed:18020708).  Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation (PubMed:18020708).  Promotes degradation of mtrm at the oocyte-to-embryo transition (PubMed:24019759).
What are the official names of this protein?
Protein cortex.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CORT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEC2_HHV11
Sequence: MAGLGKPYTGHPGDAFEGLVQRIRLIVPSTLRGGDGEAGPYSPSSLPSRCAFQFHGHDGSDESFPIEYVLRLMNDWAEVPCNPYLRIQNTGVSVLFQGFFHRPHNAPGGAITPERTNVILGSTETTGLSLGDLDTIKGRLGLDARPMMASMWISCFVRMPRVQLAFRFMGPEDAGRTRRILCRAAEQAITRRRRTRRSREAYGAEAGLGVAGTGFRARGDGFGPLPLLTQGPSRPWHQALRGLKHLRIGPPALVLAAGLVLGAAIWWVVGAGARL
What is the function of this protein?
Plays an essential role in virion nuclear egress, the first step of virion release from infected cell.  Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2.  Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space.  There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.
What are the official names of this protein?
Nuclear egress protein 2.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae NEC2 protein family.
What are the subcellular locations of this protein?
Host nucleus inner membrane; Single-pass membrane protein. Note=Localizes also at the transient membrane of perinuclear virions.
Protein: PYL2_ARATH
Sequence: MSSSPAVKGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHDDE
What is the function of this protein?
Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition.  Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (PubMed:19893533, PubMed:19898420, PubMed:23844015, PubMed:21658606).  Can be activated by both (-)-ABA and (+)-ABA (PubMed:23844015).
What are the official names of this protein?
Abscisic acid receptor PYL2, PYR1-like protein 2, Regulatory components of ABA receptor 14.
What is the protein family that this protein belongs to?
Belongs to the PYR/PYL/RCAR abscisic acid intracellular receptor family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell membrane. Note=Localizes at the plasma membrane in the presence of a CAR protein.
Protein: OLEG_PINMS
Sequence: MQKIHDHTPNPTQILGFITLFVSGAVLLFLTGLTLTGTVVGLVVLTPVLIFFSPILIPLATVLFVAVAGFLSAGGFGLAALSAISWLYNYIKGRHPPGADQIDYARMRIADTATHVKDYAREYGGYLQSKIQDAAPGA
What are the official names of this protein?
Oleosin G.
What is the protein family that this protein belongs to?
Belongs to the oleosin family.
What are the subcellular locations of this protein?
Lipid droplet. Membrane; Multi-pass membrane protein. Note=Surface of oil bodies. Oleosins exist at a monolayer lipid/water interface.
Protein: RIMO_BRUC2
Sequence: MSAPRVSFVSLGCPKALVDSERIITGLRSEGYEISRKHDGADLVIVNTCGFLDSARDESLEAIGLALNENGKVIVTGCLGAEPDVIRERHPNVLAITGPQAYESVMNAVHEVAPPAHDPFVDLVPPQGVKLTPRHYAYLKISEGCSNRCSFCIIPALRGDLVSRPINEVLREAEKLVQAGVKEILVISQDTSAYGLDIKYQEAMWQDRTVRTKFLDLSRELGEMGVWVRMHYVYPYPHVDEVIPLMAEGKILPYLDIPFQHASPAVLKNMRRPAHQEKTSRRIQAWRETCPDLAVRSTFIVGYPGETEEDFQMLLDWLDEAKIERAGCFKYEAVKGAKANDLGLEQVPEEVKEARWHRFMAKQQQISTNLLKKKVGKRLPVIIDEANGTIGKGRTRYDAPEIDGSVHISSRRPLRVGDIVTVKIEASDAYDLHGTAV
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y3776_MYCTU
Sequence: MFEISLSDPVELRDADDAALLAAIEDCARAEVAAGARRLSAIAELTSRRTGNDQRADWACDGWDCAAAEVAAALTVSHRKASGQMHLSLTLNRLPQVAALFLAGQLSARLVSIIAWRTYLVRDPEALSLLDAALAKHATAWGPLSAPKLEKAIDSWIDRYDPAALRRTRISARSRDLCIGDPDEDAGTAALWGRLFATDAAMLDKRLTQLAHGVCDDDPRTIAQRRADALGALAAGADRLTCGCGNSDCPSSAGNHRQATGVVIHVVADAAALGAAPDPRLSGPEPALAPEAPATPAVKPPAALISGGGVVPAPLLAELIRGGAALSRMRHPGDLRSEPHYRPSAKLAEFVRIRDMTCRFPGCDQPTEFCDIDHTLPYPLGPTHPSNLKCLCRKHHLLKTFWTGWRDVQLPDGTIIWTAPNGHTYTTHPDSRIFLPSWHTTTAALPPAPSPPAIGPTHTLLMPRRRRTRAAELAHRIKRERAHVTQRNKPPPSGGDTAVAEGFEPPDGVSRLSLSRRVH
What are the official names of this protein?
Uncharacterized protein Rv3776.
Protein: SDHA_SERS3
Sequence: MNLPVREFDAVVIGAGGAGMRAALQISQMGLSCALLSKVFPTRSHTVSAQGGITVALGNTHEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAVLELEHMGLPFSRLDDGSIYQRPFGGQSRNFGGEQAARTAAAADRTGHALLHTLYQQNLKNHTTIFSEWYALDLVKNQDGAVMGCTAICIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMALRAGVPVQDMEMWQFHPTGIAGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKDVLESRLPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTGQVLAVNEQGEDVVIPGLFAVGEIACVSVHGANRLGGNSLLDLIVFGRSAGMHLQESLEEQGATRDASNSDIEASLDRLNRWNSTRSGEDPVEIRKALQACMQHNFSVFREGDAMAKGLEELKVIRERLKNARLDDTSNDFNTQRIECLELDNLMETAYATAVSANFRTESRGAHSRFDYPDRDDDKWLCHTLYQPQTESMTRRKVNMQPKLRPAFPPKVRTY
What is the function of this protein?
Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.
What are the official names of this protein?
Succinate dehydrogenase flavoprotein subunit.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VPS28_CAEEL
Sequence: MSSQNANLMREVRLFENHSEREQMENLSELFAVLNALEHLEKMFSRDHVSADEYKSECFKLIDQYKVTMRLVHGATSIEDFAKKYRLHCPAAIERIREGRPITVKDDQGNVLKHIASIVEQFITFLDALRLNTRAVDDLYPGLDDLYNAINTTSRVPIDAIVTTKVKKWHDRLSSMAASDEISDEDARQMIFDVESAYQAFNKALNELKH
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 28 homolog, ESCRT-I complex subunit VPS28.
What is the protein family that this protein belongs to?
Belongs to the VPS28 family.
What are the subcellular locations of this protein?
Endosome.
Protein: Y360_CALMQ
Sequence: MFKPYNLEQGKFLVRLARRAVEEFIRSKRIIKPPEDTPSRLLEDNYGVFTTIETIREDGSTELRGCIGFPRGNVNTVKATINSALAAAFDDPRFAPLDVNELESVIFEVSVLSPLEEAKFNSPKELVNLVKVGVHGLVIERGMYSGLLLPQVPVEYCWDTVMFLDEACEKAYLRPECWAEKGTRVYTYEAQIFREKGPRGDVYERDLIEELKKCHLDEA
What are the official names of this protein?
Protein Cmaq_0360.
Protein: TSC10_CANGA
Sequence: MFCLEDQVVLIAGGSQGLGKQFGQKYWDESRHSKIILVSRSDVKLRNAITDITGGRQEPVELVMPEVAASEPSASGSSAINLSKSSNHAGFESELRSNSNRSSSSLKESTNVVTHLTTNAADSRIVYIACDLSDPDAVERMFVTLQHNNLLPTQVLACAGGSIPKLFTDLTAKELEMGVKMNYMTTLFVIHKAAQMVPQAHLILFSSSTAFFPFIGYSQYAPAKVSLKALTSILRHELPNTRISCVYPGNFYSEGYVLEEMSKPDITKSIEGSSYPISCEECCDKIVWWLNRGYDDVTTDSIGWFLMSLDMGLNKHNNNSAYWFVQWLIGVIANLLVVPFYMVLCSYQINKWHKQNKNKNTLL
What is the function of this protein?
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
What are the official names of this protein?
3-ketodihydrosphingosine reductase TSC10, 3-dehydrosphinganine reductase, KDS reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: AROQ_ALIFM
Sequence: MSTQSRILVLNGPNLNLLGLREPAHYGSQNLEQIVNALTTQADALGVEIEHLQSNREYELIEAIHNAYQRIDFIIINPAAFTHTSVALRDALLGVDIPFIEVHLSNVHAREPFRHHSYLSDKAVGVICGLGADGYEFALNAAVKRLRSN
What is the function of this protein?
Catalyzes a trans-dehydration via an enolate intermediate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type II DHQase.
What is the protein family that this protein belongs to?
Belongs to the type-II 3-dehydroquinase family.
Protein: HEM6_YERPY
Sequence: MNSPDIALIKTYLLTLQDNICAALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHRPELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQIYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BSSB_THAAR
Sequence: MSATPHTQVHWEENTARPCRKCKWQTPDPTDPLRGQCTVNRHAMGGVWKRWIRDVEHMTCSRHEEGELSFRDHV
What is the function of this protein?
Catalyzes the addition of fumarate to the methyl group of toluene, leading to the formation of benzylsuccinate.
What are the official names of this protein?
Benzylsuccinate synthase beta subunit.
Protein: TM208_BOVIN
Sequence: MAPKGKVGTRGKKQIFEENKETLKFYLRIILGANAIYCLVTLVVFYSSASFWAWMALLFSLAVYGASYHSMSSMARAAFSEDGALVDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYIWSFWLLAPGRALYLLWVNVLGPWFTADSGAPAPEHNEKRQRRQERRQMKRL
What is the function of this protein?
May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
What are the official names of this protein?
Transmembrane protein 208.
What is the protein family that this protein belongs to?
Belongs to the TMEM208 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TM11F_HUMAN
Sequence: MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFYYLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIASKTGM
What is the function of this protein?
Probable serine protease.
What are the official names of this protein?
Transmembrane protease serine 11F, Airway trypsin-like protease 4.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: YIDD_RICTY
Sequence: MTKILLLTITFYKYFISPLLGNNCIFSPTCSEYAQEAIITHGIIKGLWLTFRRIIKCQPFCIGGYDNVPTSIKNSKQPTKKI
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RUVB_CAMJ8
Sequence: MDRIVEIEKYSFDETYETSLRPSNFDGYIGQESIKKNLNVFIAAAKKRNECLDHILFSGPAGLGKTTLANIISYEMGANIKTTAAPMIEKSGDLAAILTNLSEGDILFIDEIHRLSPAIEEVLYPAMEDYRLDIIIGSGPAAQTIKIDLPKFTLIGATTRAGMLSNPLRDRFGMQFRLEFYKDSELALILQKAALKLNKTCEEKAALEIAKRSRSTPRIALRLLKRVRDFADVNDEEIITEKRANEALNSLGVNELGFDAMDLRYLELLTAAKQKPIGLASIAAALSEDENTIEDVIEPYLLANGYIERTAKGRIASAKSYSALKLNYEKTLFEE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: DNAJ_ALKEH
Sequence: MSKSDYYEALGVARNASDSEIKKAYRRMAMKYHPDRNPGDKEAEARFKEAKEAYEILSDPQKRAAYDQFGHAGVDPSAGMGGAGGPGGPGGPDFADIFSDVFGDIFGGGGRRGGGGRRVFRGADLRYNLELSLEDAVRGTEVQIRVPTQEVCDACDGKGTKEGSQPETCPTCKGHGDVRIQQGFFSVQQTCPRCGGSGSVITDPCRKCGGRGRVQSQKTLSVRVPAGVDTGDRIRLSGEGEPGENGGPPGDLYVQIMVREHEFFQRDGANLRCEVPISITKAALGGEVEVPTLDGRVNLRIPAGAQSGKVFRVRGKGVKPVRGGPQGDLLCRVHVETPVNLTKKQKELLEEFGRTMDDTGDKHTPRTSSWLDKARKFFEDWKL
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.