PharMolix/UniProtQA huggingface dataset:
Protein: URE1_CUPNH
Sequence: MAKISRQAYAEMFGPTTGDRLRLADTGLIIEIEKDFTIYGEEVKFGGGKVIRDGMGQSQRMASDCVDTVITNALIVDHWGIVKADIGLKGGRIAAIGKAGNPDIQPGVTIVVGPGTEVIAGEGMIVTAGGIDSHIHFICPQQIEEALMSGVTTMIGGGTGPATGTFATTVTPGPWYMERMLQAADAYPMNIGLLGKGNASQQGPLLEQVEAGAIGLKLHEDWGTTPAAIDTCLSVADATDTQVAIHTDTLNEAGFVEATIAAFKGRTIHTYHTEGAGGGHAPDIIKVCGEANVLPSSTNPTRPYTVNTLDEHLDMLMVCHHLDPSIAEDIAFAESRIRRETIAAEDILHDLGAFSMISSDSQAMGRVGEVIIRTWQTAHKMALQRGKLPGDPNDARGGHDNFRVKRYVAKYTINPALTHGIAHEVGSVEVGKWADLVLWRPAFFGVKPSLILKGGMIAAAAMGDPNASIPTPQPVHYRPMFASAGGALHRSSLTFVSQAALAAGIGERYGLAKTLSAVRGTRTVSKRDMVHNDWQPHVTVDPETYQVVADGQLLTCEPATELPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: APLP2_HUMAN
Sequence: MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
What is the function of this protein?
May play a role in the regulation of hemostasis.  The soluble form may have inhibitory properties towards coagulation factors.  May interact with cellular G-protein signaling pathways.  May bind to the DNA 5'-GTCACATG-3'(CDEI box).  Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.  Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
What are the official names of this protein?
Amyloid beta precursor like protein 2, APPH, Amyloid beta (A4) precursor-like protein 2, Amyloid protein homolog, Amyloid-like protein 2, APLP-2, CDEI box-binding protein, CDEBP, Sperm membrane protein YWK-II.
What is the protein family that this protein belongs to?
Belongs to the APP family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Nucleus.
Protein: GPMI_DINSH
Sequence: MTAPKPVVLCILDGWGLDPDGPANAPLLADTPVMDRLMATCPNATLTTFGPDVGLPSGQMGNSEVGHTNIGAGRVVAMDLGQIDLAIEDGSFARNPALTGFIDRLKSSGGTAHLMGVASDGGVHGHTDHIIAAAKAVAGAGVPVVLHAITDGRDVAPKSADRFMPALEAALPEGARIGTVIGRYYAMDRDNRWDRVARAFVAMVRAQGETAESAQAAVAAAYGRGETDEFIAPTVIGGYAGMRDGDGIFCLNFRADRAREILRAMAQPDFDAFDPAGLPDFAAKLGMVSYSDEHDGWFDIVFPKREIVNTLGAWVAKQGLRQFRLAETEKYPHVTFFLNGGQETPETGEDRFMPDSPKVATYDLQPEMSAEEVSDSFVAAIEAGYDLIVVNYANPDMVGHTGDLEAAKAACTAVDTGLGRALAALEVAGGAMIVTADHGNCETMIDPETGGTHTAHTLNPVPVILVGGPEGATLAPGRLADLAPTILHLMHLPQPVEMTGRSLIR
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-independent phosphoglycerate mutase, BPG-independent PGAM, Phosphoglyceromutase, iPGM.
What is the protein family that this protein belongs to?
Belongs to the BPG-independent phosphoglycerate mutase family.
Protein: D1B_HADVE
Sequence: CSRSDGWCGKTEDCCCPMKCIKAWYKQNGNCQNTISAIWKNC
What is the function of this protein?
Lethal neurotoxin.  Slows the inactivation of tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3 of the channel, resulting in repetitive firing in autonomic and motor nerve fibers.
What are the official names of this protein?
Delta-hexatoxin-Hv1b, Delta-HXTX-Hv1b, Delta-atracotoxin-Hv1b, Delta-ACTX-Hv1b.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 06 (delta-actx) family.
What are the subcellular locations of this protein?
Secreted.
Protein: MUS81_RAT
Sequence: MAEPVRLGRKRPLPVCPNPLFVRWLTEWRDEAASRGRHTRFVFQKALRSLQRYPLPLRNGKEAKILQHFGDRLCRMLDERLKEHLASGGDHAPSSPSGKKRASKGPPAQVQGSSMPVPTQPQAGSTNAGYWPAQNSGAREILLQLYREHLNSDGHSFLTKEELLQKCAQKTPRVVPESSRPWPALRGLLHRNLVLRTHRPARYALTPEGLELAQKLAEAEGLSTLNTAFQPEEHHEESPVPEAILSEPGTTEVGVQQRPLELRPSEYRVLLCVDIGETRGAGHRPEMLRELQRLRVPHTVRKLHVGDFVWVAQETRPRDPERPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLGHRIYLVEEHGSVQNLSLPESTLLQAVTNTQVIDGFFVKRTMDIKESAGYLALLTKGLERLYQGHTLHSRPWGTPGDAESEAKPSTNPLCSLLTFSDFNAEAVKNKAQSVREVFARQLMQVRGLSGEKAAALVDRYSTPASLLAAYDACATTKEQEMLLSTVKCGRLQRNLGPALSRTLYQLYCSHSPLT
What is the function of this protein?
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick.  Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions.  May be required in mitosis for the processing of stalled or collapsed replication forks.
What are the official names of this protein?
Crossover junction endonuclease MUS81.
What is the protein family that this protein belongs to?
Belongs to the XPF family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Recruited to foci of DNA damage in S-phase cells.
Protein: FLIE_PSEA8
Sequence: MSQGVEFNRLMLEMRSMQMEAMAKAKPVQAPAEVGAPSFSEMLSQAVDKVNETQQASTAMANAFEVGQSGVDLTDVMIASQKASVSFQAMTQVRNKLVQAYQDIMQMPV
What are the official names of this protein?
Flagellar hook-basal body complex protein FliE.
What is the protein family that this protein belongs to?
Belongs to the FliE family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: RSMH_CLOBL
Sequence: MEFKHISVLLEETIDSLNIKEDGVYVDCTLGGGGHSKEILKKLSHKGKLIGIDQDTSAIKAAKEKLKDYENIIYVHNNFYNIDSILEELDIDKVDGIIMDLGVSSYQLDEASRGFSYMKDAPLDMRMNREENFSAYNVVNSYEEEELFKILKNYGEEKFSRKIARFIVEKRTENPIETTGELVEIIRKAIPAKFQREGHPAKRTFQAIRIEVNKELQILNKAIEDSVNRLNKDGRLSIITFHSLEDRIVKVKFKELEKPCTCPPSFPICVCGKEPQIKIITKKPIEPSKEEKEINSRSRSAKLRVCRKI
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOB_SALPB
Sequence: MDYTLTRIDPNGENDRYPLQKQEIVTDPLEQEVNKNVFMGKLHDMVNWGRKNSIWPYNFGLSCCYVEMVTSFTAVHDVARFGAEVLRASPRQADLMVVAGTCFTKMAPVIQRLYDQMLEPKWVISMGACANSGGMYDIYSVVQGVDKFIPVDVYIPGCPPRPEAYMQALMLLQESIGKERRPLSWVVGDQGVYRANMQPERERKRGERIAVTNLRTPDEI
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit B, NADH dehydrogenase I subunit B, NDH-1 subunit B.
What is the protein family that this protein belongs to?
Belongs to the complex I 20 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SKOR1_MOUSE
Sequence: MALLCGLGQVTLRLWVPLPFQSENRIGFLAAGAFLRSGGMEALTTQLGPGREGSSSPNSKQELQPYSGSSALKPNQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPKLPENFAFDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLSDKSATDELSHAWEDVKAMFNGGTRKRTFSLQGGGGGGANSGSGGAGKGGAGGGGGPGCGSEMAPGPPPHKSLRCGEDEAAGPPGPPPPHPQRALGLAAAASGPAGPGGPGGSAGVRSYPVIPVPSKGFGLLQKLPPPLFPHPYGFPTAFGLCPKKDDPVLVAGEPKGGPGTGSSGGAGTAAGAGGPGAGHLPPGAGPGPGGGTMFWGHQPSGAAKDAAAVAAAAAAATVYPTFPMFWPAAGSLPVPPYPAAQSQAKAVAAAVAAAAAAAAAAAGGGGPESLDGAEPAKEGSLGTEERCPSALSRGPLDEDGADEALPPSLGPLPPPPPPPARKSSYVSAFRPVVKDAESIAKLYGSAREAYGSGPARGPVPGTGTGGGYVSPDFLSEGSSSYHSASPDVDTADEPEVDVESNRFPDEEGAQDDTEPRAPSTGGGPDGDQPAGPPSVTSSGADGPTDSADGDSPRPRRRLGPPPAIRSAFGDLVADDVVRRTERSPPSGGYELREPCGPLGGPGAAKVYAPERDEHVKSTAVAAALGPAASYLCTPETHEPDKEDNHSTTADDLETRKSFSDQRSVSQPSPANTDRGEDGLTLDVTGTQLVEKDIENLAREELQKLLLEQMELRKKLEREFQSLKDNFQDQMKRELAYREEMVQQLQIVRDTLCNELDQERKARYAIQQKLKEAHDALHHFSCKMLTPRHCTGNCSFKPPLLP
What is the function of this protein?
Inhibits BMP signaling (By similarity).  Acts as a transcriptional corepressor of LBX1.
What are the official names of this protein?
SKI family transcriptional corepressor 1, Fussel-15 homolog, Ladybird homeobox corepressor 1, Lbx1 corepressor 1, Transcriptional corepressor Corl1.
What is the protein family that this protein belongs to?
Belongs to the SKI family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KITH_STRMU
Sequence: MTVLAQLYYKYGTMNSGKTIEILKVAHNYEEQGKPVVIMTSSLDTRDGFGVVASRIGMRREAVTITDDMDIFAYIENMFKKPYCILIDESQFLSQKNVYDLARIVDELDVPVMAFGLKNDFQNHLFEGSRELLLLADKIEEIKTICQFCSKKATMVLRTENGRPVYKGNQIQIGGNETYIPVCRRHYFHPPIKA
What are the official names of this protein?
Thymidine kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSLU_METCA
Sequence: MSQMTPREIVHELDKHIVGQAEAKRAVAIALRNRWRRAQVGAPLRDEITPKNILMIGPTGVGKTEIARRLARLANAPFIKVEATKFTEVGYVGRDVESIIRDLTDAAIKMIRQTETAKVQSRAEAAAEERVLDALVPHASTWNAGEEGDSPARQKFRQKLRAGELNDKEIEIDVSAAPIGVEIMAPPGLEEMSSQLQNLFQNFQAGRTRTRKLRVRDALKLLKEEEAGKMINEEEIKLRAVHAVEQNGIVFLDELDKICKRADYGGPDVSREGVQRDLLPLVEGCTVSTKYGTIRTDHILFIASGAFHLAKPSDLIPELQGRFPIRVELNPLSADDFVRILTEPDASLTAQYAALLATEGVNLEFADSAIRRIAQISWEVNERTENIGARRLHTVLERLLEEISFDAADRSGTSITIDAGYVDAHLGSLALDEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y862_YERPY
Sequence: MSIENTLPTYPSLALALSQQAVALTPAEMHGLISGMLCGGSKDNGWQTLVHDLTNEGVAFPQALSLPLQQLHEATQEALENEGFMFQLLIPEGEDVTVFDRADALSGWVNHFLLGLGMLQPKLAQVKDEVGEAIDDLRNIAQLGYDEDEDQEELAQSLEEVVEYVRVAAILCHIEFTQQKPTAPEMHKPTLH
What are the official names of this protein?
UPF0149 protein YPK_0862.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: YLK3_SCHPO
Sequence: MPIDTPLIPHKPISRYRSGRLEGLESESSSESDYEEVSDSHDQENSISSSRHVITPVFEKEGISETKTSSNFQNINPVQTIDNSASEYETDASSAEGGSNSAASSSEEEDSSDSEYEMELRRRTLLLPPKFTSKVIKNRAKANEEDTEVLKKVTSQKILEETIKRELLLKETKNNNELLNDIDDTDGIDPQSEYELWKLRHLLRKKRDKEKSLELEREKMAIEERRLMNSEEREAQDLKDAEASRRGKKKSSMQFLQKYYHKGAFYQNEDIVSKRDYSEATEGEVLNKDLLPKPMQIRGDLFAKAGQTRWTHLANEDTTKEGSAWYDPKNPILQKNLHRLGGLHSDSPLSKRKRT
What are the official names of this protein?
Uncharacterized protein C1782.03.
Protein: EDD_PSEAE
Sequence: MHPRVLEVTRRIQARSAATRQRYLEMVRAAASKGPHRGTLPCGNLAHGVAACGESDKQTLRLMNQANVAIVSAYNDMLSAHQPFERFPGLIKQALHEIGSVGQFAGGVPAMCDGVTQGEPGMELSLASRDVIAMSTAIALSHNMFDAALCLGVCDKIVPGLLIGSLRFGHLPTVFVPAGPMPTGISNKEKAAVRQLFAEGKATREELLASEMASYHAPGTCTFYGTANTNQLLVEVMGLHLPGASFVNPNTPLRDELTREAARQASRLTPENGNYVPMAEIVDEKAIVNSVVALLATGGSTNHTLHLLAIAQAAGIQLTWQDMSELSHVVPTLARIYPNGQADINHFQAAGGMSFLIRQLLDGGLLHEDVQTVAGPGLRRYTREPFLEDGRLVWREGPERSLDEAILRPLDKPFSAEGGLRLMEGNLGRGVMKVSAVAPEHQVVEAPVRIFHDQASLAAAFKAGELERDLVAVVRFQGPRANGMPELHKLTPFLGVLQDRGFKVALVTDGRMSGASGKVPAAIHVSPEAIAGGPLARLRDGDRVRVDGVNGELRVLVDDAEWQARSLEPAPQDGNLGCGRELFAFMRNAMSSAEEGACSFTESLNGWR
What is the function of this protein?
Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.
What are the official names of this protein?
Phosphogluconate dehydratase, 6-phosphogluconate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CBID_SYNS9
Sequence: MSSGLTLPVWVAAAAKASLHALLGQPFAAQASVSLPDRPAPLLVPVISAARLDGGEQALAISRCDPGPGLDLTRDLEIWVRVSWTPDKQAGLTLLAGAGVGTRGAGGDLCVSAYARDLLERNLLPLDRGLTVEVVLPKGRELALRTSNAAFGVVDGLALIGTQAEVQRSAAPDQLKQVLLDLAQLTGDPEFRGDLILVIGENGLDLARQAQLAPLLKVGNWLGPVLVAAAEAGVQNLLLLGYHGKLIKLAGGIFHTHHHLADGRLEVLTALGFDAGLSLQQLRLLRHAQSVEQAFKALAAVNPAMAEQLGQQLALAVEQRSQAYVARYGDWPMRIGAVLFDRNRHLRWRGPVAGERFFTLMD
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: LONM_CANDC
Sequence: MIKASKCNKARALFLVRTSIPRTFIRNATSAIPTTVKLKDLSSLPPLTKSLPTNLPFLMPDTLHNLLRFDSKKEKQPSTDKSNDKDKPSRKEKGKDKEKENEERKDINEDEKYDIKEETDSKPTIDPNNPVSSKSSISSSSGGANNNNNNDDSDGRDDDGSPKDKEFLSPSDAGLHPPFLAIAMKDRPFLPGATRHLHVTDPEVIKCVNHMINSNIKSPYFVLFHVRDTNSEDAALDVIKDRDFVHEVGTLCQIIKTTGSEILVYPHYRVKLVDISTPNSRSERIEMEQDNSQTSYLKKFEVSYAVTQQLKDEPYDEQSITINAWTRRIKELYEKLAPKYEQPENKEEIMNNPSMLADFIASKVHAKPEQIQQILESSNVETKLELSLQLLQVEADADEMRQTALKNIRERTEKAYAQSLIKEYTKELLKAAGIGENSKVHKFDERIKHLKMPEEAMKAYKTEKERLGTQSDMEQNVVERYLDWLTQIPFGVYTKDSFNVKKAREILDRDHYGLKDVKDRILEFISVGKISGNVDGRILCLAGPPGTGKTSIAKSIAEALNRKYTRIAVGGVQDVHDVKGHRRTYVASIPGRIVTALTQAKTSNPLMLIDEIDKLDTTSHGGAARAFLEILDPEQNNSFVDNFIEVKVDLSKVLFVCTANYLGSIPAPLRDRMEIIEVNGYTKNDKIEITKRHLIPAAAKKVGLEEGRVVIPDETILRLIDKYCRESGLRHIKSLINRIFSKASRKIVEELEDTDADPHSREIVEESLVAKENESVISDKAKKDAGSSSIESNDSNTEAKVSTTTENEKKQEQKQKQDEEIKKLDLPADLKIEVKPETLKDFVGPEIYIKDRLYETLNPGVATGLAYNTSGDGDALYIESILTDSISSDLGNAGLHVTGSLKEVMKESASIAYSFAKQFMVRQFPDNRFFEAAHIHVHCPGGAIPKDGPSAGIAFTSSLVSLALNKSLPNDTAMTGEITLTGKVLAIGGLREKSLGAKRAGYTKIIFPKDCEYQLDEIPDEVKEGLTYIPVEWYSEVFEHLFKGISKEEGNSVWKEEFAKLEEKKKSKKTHTV
What is the function of this protein?
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix.  May also have a chaperone function in the assembly of inner membrane protein complexes.  Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome.  Binds to mitochondrial DNA in a site-specific manner.
What are the official names of this protein?
Lon protease homolog, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the peptidase S16 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: TF2B_AERPE
Sequence: MASEIPYDESPSGEESGEIKCKNIVTDPVRGLKICADTGEIIGEDIIGTESDVKAYTPEERQQKTHYGGPLKYSHHYMGVEASLEHPRDHGPKGIKQRKILPRRPPRLSARPLTSVDKNLQTALSLINEVASRMGMPEIVVEDASKIYREAMEKGLTRGRSIESIVAASLYAASRIHGLPHSLTDIIKAMKGNVDAETRRDVARSYRLLVRDLNIKIPVRKPENFVYTIISALGLPEHVAIEAIKIIDLSRKKGLTAGKDPGGLAGAAVYLAALKHGIRKTQKEIAHVVGVTEVTIRNRYKEIAQALGIEEELEEKGGEEKG
What is the function of this protein?
Stabilizes TBP binding to an archaeal box-A promoter.  Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
What are the official names of this protein?
Transcription initiation factor IIB, TFIIB.
What is the protein family that this protein belongs to?
Belongs to the TFIIB family.
Protein: HLY1_AERHH
Sequence: MKNKKPRKFITQAPTLSLLALALLAGSVQAEDIGERTDQGTAMLASLQSEQGLIYLNADVWLKRQGATPLMTRDQLRERVLARGERLFIDFSAVTDQSERQQTRKAMEQLAGISFDADWVLVSGYKGELLFTPLGGVDDPAFYQVMERVESLEGQGKRHKRSLTQPPAAEAGLPHVAFYLNVNRKISDAECTFPRSRTWSRGDRLFCDSPNISLVYRVNLERSLQFGNTGSATPDAKIVRISLDEESAGAGIQLNEDLTWSENIADYLLLDGWARDYATDAIAQDYRFSIEASNTKAAVLKSLPTNLNSKYEHREISGFEVGVTGGVEVNKDGPKAKLEASAKFSQQRQLAYNTQDYRVERSAPSAQKVSFSWVRDQYATAESLLSSKTATVWGMGYDVDHNRIQPLSYKGFVPNLDVIYKAAPDETGSTEFKIDSSVNIRPIYTGIYKHYYVVGAHVSFQGFEDTDKRRRVTASTSFKVDWNHPVFTGGRPVNLQLGGFDNRCLSADANHGLSAVTCDETSAAQSFIYDQYGRYVSAQDTRRCLDGNNLGQLQSCSLSLGQRWEWKADSDALSNLSAHQLLGHDKQSGALGLYDENGNPQNVSVRTLTSYTRIFGPPASH
What is the function of this protein?
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.
What are the official names of this protein?
Hemolysin ahh1.
What is the protein family that this protein belongs to?
Belongs to the HlyA hemolysin family.
Protein: RS4_PARDP
Sequence: MTKRTAAKYKIDRRMGENIWGRAKSPLNRREYGPGQHGQRRKGKLSDFGTQLRAKQKLKGYYGDLTEKQFRRIYAEAERVKGDTGENLIGLLERRLDAVIYRAKFVPTIFAARQFVNHGHVEVNGKRVNIASYRVKEGDVVSIRERSRQLAIVLESVGLAERDVPDYLEVDHNKMTATFVRTPALGDVPYAVQMEPNLVVEFYAKN
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: H2A_PLADU
Sequence: MSGRGKGGKAKGKSKTRSSRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTTKAK
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H2A.
What is the protein family that this protein belongs to?
Belongs to the histone H2A family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: Y667_METM6
Sequence: MLKELINKLLWHPGYNPEDYVIKYLHRGAENDEKSVPLQNIVIEDSFLFFDETHIPFHRILEIVNLKNGEILYKKR
What are the official names of this protein?
UPF0248 protein MmarC6_0667.
What is the protein family that this protein belongs to?
Belongs to the UPF0248 family.
Protein: EDD_HELPJ
Sequence: MPKHSLEQIKEKITERSKKTRELYLENTFNPKNQPKIESLGCANIAHVTASMPEHLKMPLGSHKRKHFAIITAYNDMLSAHQPFKNYPDLIKKELQEHNAYASVASGVPAMCDGITQGYEGMELSLFSRDVIALSTAVGLSHNVFDGAFFLGVCDKIVPGLLIGALSFGNLASVFVPSGPMVSGIENYKKAKARQDFAMGKINREELLKVEMQSYHDVGTCTFYGTANSNQMMMEFMGLHVANSSFINPNNPLRKVLVEESAKRLASGKVLPLAKLIDEKSILNALIGLMATGGSTNHTLHLIAIARSCGVILNWDDFDAISNLIPLLAKVYPNGSADVNAFEACGGLAFVIKELLKEGLLFEDTHTIMDTETQKGMQNYTKTPFLENDQLVYKDAVSHSLNTDILRPVSEPFAANGGLKILKGNLGRAVIKISAIKDEHRKVKARAIVFKTQSEFLERFKNKELERDFVAVLPFQGPKSNGMPELHKLTTNLGALQDMGYKVALVTDGRMSGASGKVPSAIHLSPEGALNGAIIKIKDGDLIELDAPNNALNVLEKDFEKRGINPLFLETLENLEKPTFGLGRELFTSLRLNANTAEEGGMSFGIKV
What is the function of this protein?
Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.
What are the official names of this protein?
Phosphogluconate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: ILVD_METJA
Sequence: MISDRVKKGLKRAPNRSLLKACGYTDEELERPFIGVVNSFTEVVPGHIHLRDIAEAVKKGIYANGGTAFEFNTMAICDGIAMGHEGMKYSLPSREIIADTVESMAKAHGFDGLVLIPSCDKIVPGMIMGAIRTGLPFIVVTGGPMFPGELRGKKYDLISVFEGVGACAAGKITEEELKEIEDIACPGAGSCAGLFTANTMACLTEAMGLSLPYCATSHATTAEKIRIAKRSGMRIVDLVRNNITPDKILTKEAFENAILVDLALGGSTNTTLHIPAIANEVKPKFITLDDFDRLSGEVPHIASLRPGGEHFIIDLHRAGGIPAVLKVLEEKIRKECLTVSGKTIGEIIKEVKYIDYSVIRPVDNPVHETAGLRILKGSLAPNGAVVKIGAVNPKMYKHEGPARVFDSEEEAVDAILGGDIERGDVVVIRYEGPAGGPGMREMLAPTSAICGMGLDDSVALITDGRFSGGSRGPCIGHVSPEAMAGGPIAIVEDGDIIKIDMINKKLDLALDEEEIKERLAKWKKPEPKVKKGYLARYAKLVSSADEGAVLRYD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RIPK3_RAT
Sequence: MSSVKLWLNGASSISLVGSEELENLGFVGKGGFGAVFRARHTAWNLDVAVKIVNSKKISREVKAMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGSLSGLLQPSCPRPWPLLCRLLEEVVLGMCYLHSLNPSLLHRDLKPSNVLLDPELHAKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGREAEVVDKTSLIRGAVCNRQRRPPLTELPPDSPETPGLEGLKELMTHCWSSEPKDRPSFQDCESKTNNVYILVQDKVDAAVSKVKHYLSQYRSSDTKLSARESSQKGTEVDCPRETIVYEMLDRLHLEEPSGSVPERLTSLTERRGKEASFGHATPAGTSSDTLAGTPQIPHTLPSRGTTPRPAFTETPGPDPQRNQGDGRNSNPWYTWNAPNPMTGLQSIVLNNCSEVQIGQHNCMSVQPRTAFPKKEPAQFGRGRGW
What is the function of this protein?
Serine/threonine-protein kinase that activates necroptosis and apoptosis, two parallel forms of cell death.  Necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members, is triggered by RIPK3 following activation by ZBP1.  Activated RIPK3 forms a necrosis-inducing complex and mediates phosphorylation of MLKL, promoting MLKL localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.  In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.  Also regulates apoptosis: apoptosis depends on RIPK1, FADD and CASP8, and is independent of MLKL and RIPK3 kinase activity (By similarity).  Phosphorylates RIPK1: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation (By similarity).  In some cell types, also able to restrict viral replication by promoting cell death-independent responses.  In response to flavivirus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with ZBP1, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate.  Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity).  RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL.  These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).
What are the official names of this protein?
Receptor-interacting serine/threonine-protein kinase 3, Homocysteine respondent protein HCYP2, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Mainly cytoplasmic. Present in the nucleus in response to influenza A virus (IAV) infection.