PharMolix/UniProtQA huggingface dataset:
Protein: BIOH_SALCH
Sequence: MNDIWWQTYGEGNCHLVLLHGWGLNAEVWHCIREELGSHFTLHLVDLPGYGRSSGFGAMTLEEMTAQVAKNAPDQAIWLGWSLGGLVASQMALTHPERVQALVTVASSPCFSAREGWPGIKPEILGGFQQQLSDDFQRTVERFLALQTLGTETARQDARTLKSVVLAQPMPDVEVLNGGLEILKTVDLREALKNVNMPFLRLYGYLDGLVPRKIAPLLDTLWPHSTSQIMAKAAHAPFISHPAAFCQALMTLKSSL
What is the function of this protein?
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete.  It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
What are the official names of this protein?
Pimeloyl-[acyl-carrier protein] methyl ester esterase, Biotin synthesis protein BioH, Carboxylesterase BioH.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FDB30_GIBM7
Sequence: MALHKKGISFTLYEDAKEYSAVGAGIGFAPNGMRTMDLIEPAFRPLYEAICVGNKGEDAQDIFFEGMLVEEGLGRDKPWYGHSGWGHPDYVRKSAHRKTLLDIMTSFIPIENVKFNKRLTNIEQRPDGVTLSSQDGTTAECSVLAGADGIKSTVRANVLEHYPNQIAPVYAGAYCYRAVIPMAEAYEILGDLTDVAKIYFGHGRGAVTYRISGGDEFNYLLCVDDSLDGWKLEGAVTETISHEAMMSDFEDPRIDDRLRQLLTKAKPVKWGFFHHIRTASYYRDRVALIGDSAHASLPFQAAGAAQGLEDALVLSSILSEVAKMPERGADLAPFIKAGLSAYDSVRRPRAQKQLEQAAEVGRMIFFQHEEAGADMDKILPRLQQGRFNWLWFHDTNDDVKEAIKRMQKQISVGGPSVARI
What is the function of this protein?
FAD-dependent monooxygenase; part of the Fusarium detoxification of benzoxazolinone cluster 2 (FDB2) involved in the degradation of benzoxazolinones produced by the host plant (PubMed:19302487, PubMed:26808652).  Maize, wheat, and rye produce the 2 benzoxazinone phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their inherent instability once released, spontaneously degrade to the more stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).  The first step in the detoxification of benzoxazolinones involves the hydrolysis of the cyclic ester bond of benzoxazolinones by the FDB1 cluster gamma-lactamase MBL1 to aminophenols (PubMed:26808652, PubMed:12788712).  MBL1 is able to convert BOA into 2-aminophenol (2-AP), as well as MBOA into 5-methoxy-2-aminophenol (2-AMP) (PubMed:26808652, PubMed:12788712).  The FDB2 cluster N-malonyltransferase FDB2/NAT1 then metabolizes aminophenols via N-malonylation to non-toxic malonamic acids (PubMed:19302487, PubMed:12788712).  FDB2/NAT1 converts 2-AP into N-(2-hydroxyphenyl) malonamic acid (HPMA) and 2-AMP into N-(2-hydroxy-4-methoxyphenyl) malonamic acid (HMPMA) (PubMed:19302487, PubMed:12788712).  The duplicated dienlactone hydrolases DLH1 and DLH2 may provide redundant function for hydrolyzing the lactone moiety in the BOA molecule (Probable).  The roles of the amidases an other enzymes encoded by the 2 FDB clusters have not been identified so far (Probable).
What are the official names of this protein?
FAD-dependent monooxygenase FVEG_12630, Fusarium detoxification of benzoxazolinone cluster 2 protein FVEG_12630, FDB2 cluster protein FVEG_12630.
What is the protein family that this protein belongs to?
Belongs to the paxM FAD-dependent monooxygenase family.
Protein: NDHM_ORYSJ
Sequence: MATTASPFLSPAKLSLERRLPRATWTARRSVRFPPVRAQDQQQQVKEEEEEAAVENLPPPPQEEEQRRERKTRRQGPAQPLPVQPLAESKNMSREYGGQWLSCTTRHIRIYAAYINPETNAFDQTQMDKLTLLLDPTDEFVWTDETCQKVYDEFQDLVDHYEGAELSEYTLRLIGSDLEHFIRKLLYDGEIKYNMMSRVLNFSMGKPRIKFNSSQIPDVK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit M, chloroplastic, NAD(P)H dehydrogenase subunit M, NDH subunit M, NDH-M, NADH-plastoquinone oxidoreductase subunit M.
What is the protein family that this protein belongs to?
Belongs to the NDH complex subunit M family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: PROF4_HEVBR
Sequence: MSWQTYVDDHLMCDIDGHRLTAAAIIGHDGSVWAQSSSFPQFKSDEVAAIMKDFDEPGSLAPTGLHLGSTKYMVIQGEPGAVIRGKKGSGGITVKKTSQALIIGIYDEPLTPGQCNMIVERLGDYLLEQGM
What is the function of this protein?
Binds to actin and affects the structure of the cytoskeleton.  At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.  By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
What are the official names of this protein?
Profilin-4, Pollen allergen Hev b 8.0202.
What is the protein family that this protein belongs to?
Belongs to the profilin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: OPGC_SALPB
Sequence: MSSVPAPREYFLDSIRAWLMLLGIPFHISLIYSTHSWHVNSATPSWWLTLFNDFIHAFRMQVFFVISGYFSYMLFLRYPLKRWWKVRVERVGIPMLTAIPLLTLPQFILLQYVKEKTENWPTLSAYEKYNTLAWELISHLWFLLVLVILTTVSIGIFTWFQKRQETSKPRPAAISLVRLSLIFFLLGMAYAAIRRIIFIVYPAILSDGMFNFIVMQTLFYVPFFILGALAFIHPDLKARFTTPSRGCTLGAAVAFIAYLLNQRYGSGDAWMYETESVITMVMGLWMVNVVFSLGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHISSNLIGFLCGLIFVMGIALILYEIHLRIPLLKFLFSGKPPVKQESRAAIG
What is the function of this protein?
Necessary for the succinyl substitution of periplasmic glucans.  Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.
What are the official names of this protein?
Glucans biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the acyltransferase 3 family. OpgC subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL15E_HALS3
Sequence: MARSFYSHIKEAWEDPDDGKLAELQWQRKQDWRKEGAIERVDRPTRLDKARELGYKAKQGVVVVRVSVRKGTARKSRFKAGRRTKRQGVNRIGRAKNLQRIAEERASRKYVNLRTLNSYWVGEDGSQKWFEAILLDPEHGAIQNDDDLNWICDDSHKNRVFRGKTSAGRRARGLQNRGKGTEGLRPSTNADKRNKS
What are the official names of this protein?
50S ribosomal protein L15e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL15 family.
Protein: STS1_YEASZ
Sequence: MGFEWGFKPSSKITQSTVSSQGTGNVMIPTAGVKQKRRYANEEQEEEELPRNKNVMKYGGVSKRRPQPGSLIRGQPLPLQRGMELMNKNQLQQLLVDLMTKHPEIQQSVHTRVIGLDFSIQKCLDMLKQKSEAVYQSIPYNRSYESNKLDDYAFVRMKPQILEFLNCLVDFILDNIPPRLENLHASLKFLDICTELVIKLPRFELASNNYYYDKCIEQLSHVWCTLIEHVARDRIILLADNSSVWKSHMTRLQVYNEHSNGLLERPLQLFKSLDMGSPSAASSSTLSLQESIIYHHDTMTANENNNNSGSAATDSPFN
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1, Dumbbell former protein 8, SEC23 suppressor 1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: MYCE_MICGR
Sequence: MTAQTEFDEATVQDVVRLAGGHDSELRELTQKYDPAMISRLLVAEILSRCPPPSNDTPVLVELAIVHGSERFRHFLRVVRDSPIRPVGADEGFVGMLVEYELTELLRELFGVTHERPAGVRGTKLFPYLTDDEEAVEQIGTYLLAAQQGTEAVLAGCGSRKPDLSELSSRYFTPKFGFLHWFTPHYDRHFRDYRNQQVRVLEIGVGGYKHPEWGGGSLRMWKSFFPRGQIYGLDIMDKSHVDELRIRTIQGDQNDAEFLDRIARRYGPFDIVIDDGSHINAHVRTSFAALFPHVRPGGLYVIEDMWTAYWPGFGGQADPQECSGTSLGLLKSLIDAIQHQELPSDPNRSPGYVDRNIVGLHVYHNVAFVEKGRNDEGGIPTWIPRDFESLVQASSGGAT
What is the function of this protein?
O-methyltransferase that catalyzes the conversion of mycinamicin VI to mycinamicin III in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic.
What are the official names of this protein?
Mycinamicin VI 2''-O-methyltransferase, Mycinamicin biosynthesis protein E.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase OleY/MycE family.
Protein: FLGI2_BURTA
Sequence: MCAFAAILSLLSVLLMATSRSSDAAPLGTLVSVEGVRDNQLVGYGLVVGLNGSGDGQQIRYTGQSIANVLKQFGVTLPEGIRLRSRNVAAVMVSANFPAGYVPGQKIDVTVSSMGDAKSLRGGTLLLTPLRAADGVVYALAQGNLVVPGVSAQGRSGSSVTINATAAGRIPQGATIEQEIPSDLDAKPSVRLSLKRPSFQTATSIVAAIDRMAGPGAATSRDGTSVEVRAPEDPTARVAFLAKLTAINVTPQKEPPRVVFNSRTGTVVISQGMTVSPAAVSHGTLKVTISEGAIVSQPNPLGGGKTAVVPLSQVDVQQDGNRMFNWPAGVSLQKIVDTINSTGASPDDVMAILQALDEAGALNGELVVI
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein 2, Basal body P-ring protein 2.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: RL37A_METM5
Sequence: MVEFSHTKKIGSAGRFGSRYGRKIRVRLRDVEIKQKKEYKCPVCAFPKLKRAGTSIWVCEKCGAKIAGGAYTPETGAGKVVTKAIRRVIESKSREI
What are the official names of this protein?
50S ribosomal protein L37Ae, Ribosomal protein L43e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL43 family.
Protein: FEN_METMJ
Sequence: MGVAIRDILADCKETLTWDDLSGIAALDAHNALYQFLSIIRQPDGTPLMNGAGRITSHLSGILFRTVNFLEKGIRPVFVFDGKPPEFKQETINERREHRARADEAWKTALREGDMEEAYKQASASARIDSHTIASSRELLDLLGIPWVQAPSEGEAQAAYMARQGKVTYAVSQDYDSLLFGSPVLVRNLTVSGRRKTRGRTITVNPERIVLSSFLDRLGVTREQLVKIGILVGTDFNPGIRGVGGKTALKIVRNGEFESVIAEKQPDFNPAPIRDFFLNPPVTDDYTLEWRTPDVEGVVEMLCGRYDFSEERVRSALAKVSVKATQKTLDAWF
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity.  Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation.  Also involved in the base excision repair (BER) pathway.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Protein: VP8_VARV
Sequence: MSLLLENLIEEDTIFFAGSISEYDDLQMVIAGAKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGDDKLTIEAIENYFLDPNNEVMPLIINNTDMTAVIPKKSGRRKNKNMVIFRQGSSPILCIFETRKKINIYKENMESASTEYTPIGDNKALISKYAGINVLNVYSPSTSMRLNAIYGFTNKNKLEKLSTNKELELYSSSPLQEPIRLNDFLGLLECVKKNIPLTDIPTKD
What is the function of this protein?
Major core structural protein.
What are the official names of this protein?
Core protein VP8, 25 kDa major core protein, L4 core protein, P25K.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG098 family.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: FER_SULAC
Sequence: GIDPNYRTSKPVVGDHSGHKIYGPVESPKVLGVHGTIVGVDFDLCIADGSCITACPVNVFQWYETPGHPASEKKADPVNEQACIFCMACVNVCPVAAIDVKPP
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Zinc-containing ferredoxin.
Protein: YQIB_ECO57
Sequence: MKRYTPDFPEMMRLCEMNFSQLRRLLPRNDAPGETVSYQVANAQYRLTIVESTRYTTLVTIEQTAPAISYWSLPSMTVRLYHDAMVAEVCSSQQIFRFKARYDYPNKKLHQRDEKHQINQFLADWLRYCLAHGAMAIPVY
What are the official names of this protein?
Uncharacterized protein YqiB.
Protein: DAPH_STRZJ
Sequence: MTATKMNAQEIIQFIANAEKKTSVKVTFEGQLATAVPSSVVKLGNVLFGDWKDVAPLLEGLVENQDYVVEQDARNSAVPLLDKRAINARIEPGAIIRDQVEIGDNAVIMMGAVINIGAEIGAGTMIDMGAILGGRAIVGKNSHVGAGAVLAGVIEPASAEPVRVGDNVLIGANAVVIEGVQIGSGSVVAAGAIVTQDVPENVVVAGVPARIIKEIDAQTQQKTALEDALRTL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: NUOK_EDWI9
Sequence: MIPLQHGLILAAILFALGLTGLLIRRNLLFMLISLEIMINAAALAFVVAGSVWGQADGQVMYILAISLAAAEASIGLALLLQLHRRRNTLNIDTVSEMRG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOA_BURP1
Sequence: MQTSLLKPKIIAVESLGENHAKVVMEPFERGYGHTLGNALRRVLLSSMVGYAPTEVTIAGVVHEYSTLDGVQEDVVNLLLNLKGVVFKLHNRDEVTVTLRKEGEGVVTAGDIELAHDCEVINPNHVIAHLSKGGKLDVQIKVEKGRGYVPGNVRRYGDETAKIIGRIVLDASFSPVRRVSYTVESARVEQRTDLDKLVMNIETSGVITPEEAIRQSARILVDQLSVFAALEGTETAAEAPSRAPQIDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTENELLKTPNLGRKSLNEIKEVLASRGLTLGMKLENWPPAGLDK
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: RS11_THEP1
Sequence: MARKRGSSSRKQKKVGFDYGVVHIKSTFNNTIITLTDKDGNTLTWASGGTVGFEGTRKGTPYAAQLAADKVAREALRMGIKKVDILVKGPGPGREPAIRTLQGAGLEINQIKDVTPIPFNGCRPKKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: ARAG2_BURCM
Sequence: MTMQTITAVSGNDDAATHGAAAPPGGALLSLDGITVTFPGVRALDAVSLSVRAGEVHGLMGENGAGKSTLLKVLSGVNQPQAGTLTLNGTVQRFASTRAALEAGIAIIYQELHLVPELTVAENLMLGQLPSRLGVVDERALAVRALDALERLGEHIDPDIPVKYLSIGQRQMIEIGKALMRDARVIAFDEPTSSLSARETTQLFRIIRSLRAEGRAIIYVTHRMEEVDALCDRVTVFRDGRRIETFESVAELDRDQLIGCMVGRSIEDVYGYRPRAAGDVMIEAKGLTGPGLSEPVSFAARRGEIVGFFGLVGAGRSELMKLLYGATRPSGGHVELGGKRVAFSSPRHAVRAGIALCPEDRKQEGIVAIASVADNLNISARRHFSPARVLLDARRERDLAQRYIERLAIKTPDGDTPIGALSGGNQQKVVLARWLAERIDVFLMDEPTRGIDVGARAEIYNLFYELAEAGRTVILVSSDLAEVIGVSDRIIVMKEGRIAGEVAKAQATPDALIKLALPR
What is the function of this protein?
Part of the ABC transporter complex AraFGH involved in arabinose import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Arabinose import ATP-binding protein AraG 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATIF2_CAEBR
Sequence: MLSVSRVASRMTGVVARFSTGGHGDGAGRGGGSGGSIRDAGGAFGKMEAAREDEYFYKKQKAQLEELRKHIQQEVDHHKSQLENHQKVLDRHQKRISEIEAEERALGKE
What is the function of this protein?
Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.
What are the official names of this protein?
ATPase inhibitor mai-2, mitochondrial, ATP synthase F1 subunit epsilon.
What is the protein family that this protein belongs to?
Belongs to the ATPase inhibitor family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: AL8A1_DANRE
Sequence: MSKDMKYLVLENYIGGKFVPCSKLIDSFDPSTGEVYCKVPDSGAEEVNAAVRAAKEAFPDWSAKSPADRSKVLNKLADLIEARLEEFVQAESKDQGKTITFARNVDIPRSAYNFRFFASSVLHHTNDCSQMDHMGCLNYTIRCPVGVAGLISPWNLPLYLLTWKIAPAVATGNTVVAKPSEMTSVTAWMMCQLLEEAGFPPGVVNIVFGTGPRAGDALVSHPDVPLISFTGSTATARLITERSAPHCKKLSLELGGKNPAIIFADADMEQCISTTVRSSFSNQGEICLCTSRIFVERSVYPEFLTRFVEATRRWKTGVPSDPSNDNGALISKEHLQKVKGYITLALAEGAQVHCGEGVDKLALPQQNIGGYFMLPTIISGVKDSSALMQEEIFGPVTCVTPFDEEEEVISRANNVRYGLSATVWSRDVGRVHRVARKLQAGLVWTNCWLVRDLNLPFGGMKHSGIGREGGKDSYHFFTEVKSVTVKH
What is the function of this protein?
Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
What are the official names of this protein?
2-aminomuconic semialdehyde dehydrogenase, Aldehyde dehydrogenase family 8 member A1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: G432_FUSSX
Sequence: MPRSPRRWTPEEDRVLLDKVKQLFSDGAKNDTTISWATVANALPDRNNKDCRKRWSKITGAKKGSWSLSEDEQLLEGVQKYGRQWAMVAKGVETRSADQCAKRWQHCLDPSLDRSEWRSDQDARLVAAVRRYGTNWKDIKKFEFPKRSTTNLKNRHITLFRQRNKAPGACPGSTETLGPGIDWWSMEQGMIDDMSMDASEDGDDAEDDQTPDSYTSISTSSFDDILGGSSSSPSAADTMTTASPDPYQYLLDWAVPSHADLVQAATSYYPSLDGFLGSTYDHNAKIDSSLGRDANGGNFIPGFPTQTPSQFESIDVSQISDGIVSGEPSRQGASRECRAASNVSSGPQMTLTIDNPDPQTMTGILEVLAKANSKVTISMNRE
What is the function of this protein?
Transcription factor; part of the gene cluster that mediates the biosynthesis of 1233A, a natural compound known as an inhibitor of HMG-CoA synthase in the mevalonate pathway and with antibacterial and antifungal activities (PubMed:32139880).  Involved in hygromycin B-induced transcriptional control of the cluster (PubMed:32139880).
What are the official names of this protein?
Myb-like transcription factor, 1233A biosynthesis cluster protein g432.
What are the subcellular locations of this protein?
Nucleus.
Protein: CD5L_HUMAN
Sequence: MALLFSLILAICTRPGFLASPSGVRLVGGLHRCEGRVEVEQKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEEVYDCSHDEDAGASCENPESSFSPVPEGVRLADGPGHCKGRVEVKHQNQWYTVCQTGWSLRAAKVVCRQLGCGRAVLTQKRCNKHAYGRKPIWLSQMSCSGREATLQDCPSGPWGKNTCNHDEDTWVECEDPFDLRLVGGDNLCSGRLEVLHKGVWGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRDRKCYGPGVGRIWLDNVRCSGEEQSLEQCQHRFWGFHDCTHQEDVAVICSG
What is the function of this protein?
Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis.  Able to inhibit lipid droplet size in adipocytes.  Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA).  CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease.  Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC).  Acts as a key regulator of metabolic switch in T-helper Th17 cells.  Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation.  CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes.  Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity).  Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828).  Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).
What are the official names of this protein?
CD5 antigen-like, Apoptosis inhibitor expressed by macrophages, hAIM, CT-2, IgM-associated peptide, SP-alpha.
What are the subcellular locations of this protein?
Secreted. Cytoplasm. Note=Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported in the cytoplasm via CD36-mediated endocytosis (By similarity).
Protein: RNH2_SALHS
Sequence: MIEFVYPHTHLVAGVDEVGRGPLVGAVVTAAVILDPARPIVGLNDSKKLSEKRRLSLYDEIKEKALSWSLGRAEAHEIDELNILHATMLAMQRAVAGLHIAPEYVLIDGNRCPELPVPSMAVVKGDSRVAEISAASILAKVTRDAEMAALDIVFPQYGFAQHKGYPTAFHLEKLAQYGATAHHRRSFAPVKRALGLVS
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: K1B9A_ANEVI
Sequence: MNLKVLAVFVLCAILVVVTAERRGTETGVYKKDTLQDLIKRTRNCIDRFPTGTCKQVKKGGSCKNSDKYRMNCRKTCGLC
What is the function of this protein?
Inhibits voltage-gated potassium channels (Kv1/KCNA).
What are the official names of this protein?
U-actitoxin-Avd9a, U-AITX-Avd9a, Potassium channel toxin avtx-6.
What is the protein family that this protein belongs to?
Belongs to the sea anemone type 1 potassium channel toxin family. Type 1b subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: RL2_NOCFA
Sequence: MAIRKYKPTTPGRRGSSVSDFAEITRSTPEKSLLRPLTKSGGRNAHGRITTRHRGGGHKRAYRVIDFRRLDKDGIPAKVAHIEYDPNRTANIALLHYVDGEKRYILAPKGVTQGTPIESGPTADIKPGNNLPLRNIPTGTTIHNVELRPGGGAKLARAAGMSIQLLGKEGPYATLRMPSGEIRRVDVRCRATVGEVGNAEQSNINWGKAGRMRWKGRRPTVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGQPEGRTRKPNRPSDKLIVRRRKTGKKR
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: RK22_CALFG
Sequence: MSSKKKQKMKRSSSTQVQALAQHISMSAHKARRVVDQIRGRSYAETLMLLELMPYRASYPIFKLVYSAAANASHNKSFNEADSFISKAEVNGGTIVKKFKPRAKGRSYPIKRPTCHITIVLKDRSKKKTDQDMFLGTKNV
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.