PharMolix/UniProtQA huggingface dataset:
Protein: SENP1_HUMAN
Sequence: MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
What is the function of this protein?
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078).  The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins.  The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.  Deconjugates SUMO1 from HIPK2 (PubMed:16253240).  Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689).  Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374).  Deconjugates SUMO2 from MTA1 (PubMed:21965678).  Deconjugates SUMO1 from METTL3 (PubMed:29506078).  Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).  Deconjugates SUMO1 from GPS2 (PubMed:24943844).
What are the official names of this protein?
Sentrin-specific protease 1, Sentrin/SUMO-specific protease SENP1.
What is the protein family that this protein belongs to?
Belongs to the peptidase C48 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
Protein: PUR5_CUPPJ
Sequence: MSASSTAGQAGLSYRDAGVDIDAGDALVDRIKPFAKRTMREGVMAGIGGFGALFELSKKYQEPVLVSGTDGVGTKLKLAFQLNRHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAATVIQGIARGCELAGCALIGGETAEMPTMYPDGEYDLAGFAVGAVEKKKIIDGTTITPGDVVLGLASSGAHSNGYSLVRKIIEVAKPDLDADFHGQRLQDAIMAPTRIYVKPLLSLIETLPVKGMAHITGGGLTENVPRVLPQNTTAVLQRDAWALPPLFQWLQSQGRVADDEMHRVFNCGIGMVVIVAKEDAERAIRHLQAAGEAVWEIGEIRERAEGQAQTVVV
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYS_DESOH
Sequence: MLDSRFVREQADRARQALAHRNEDPVMIDAFLGYDTARKDILAEIEALRHKRNVASDTIAQMKKAGQTADEPIAAMREVSAKIKELEVLLAENQEKSDALLMRIPNIPHASVPIGPDESANVTEREVGTPPAFDFAPRPHEEIGEALGIFDFARAAKIAGARFPLYKGAGALMERALINFMLDIHTTEHGYTECLPPLMVNAKTMTGTGQLPKFEEDLFKLERWGFYLIPTAEVPVTNIFADEILNEADLPIKYTAYTPCFRSEAGSYGKDTKGLIRQHQFNKVELVKFAHPEHSYDELEKLLADAETILQRLGLAYRVITLCSGDMGFSAAKTYDIEVWFPAQNRYREISSCSNFEDFQARRANIRFKRPGQKGTGFVHTLNGSGLAVGRTLAAILENFQTKEGAVEIPDTLRPYMRNMAVLSL
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAAF1_DROER
Sequence: MSHANRKEITGLTRMTPKGLKELCKKDKLYQTPRLNDVLYLHYQGFQCIENLEEYTELKCLWLECNAISEIQGLEKLGKLKCLFLQNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNILPVLNTLTIASNYLKDSDSLSDLIQCKTLSVLDLSNNRIDDILIVKIFEQMVSLKVLVLQGNPVVSRLPQYRKTLILACKELTYLDSRPVFPRDRACAEAWKRDGYEGERKENNRWKRAERRKTRESINCTIRMRNSHRPPDQQDPLLRSSDSEDDTCTETTRKKVALENDCVDDLWEEVSCEQPISDHGTSTSSSVEDKDGTSSQDDLIAEKLSNRGTLEGRPTVLYENEVSNIKSVNQNIKNFEPRSIETKVFQDVSKISPIIIEEKRVPNINLNNEPSDVKNRKVIKCEKTGYTSTGQVLKENVFDEDAEIKNVEDMVQCQDIIKSNEDMNSEFVVSTKLEKDVEQTCIALRNEAQCKELDEDQSIKEIESKLINEMYENVAADDHDKHNETVDLNLKKTASAQHARTFFFEENKMTRRFYQEDKKSSLLAKSKEEALLEEDCIISNEKCAYDLEEIGRQMEEDLAELRQSTQKLVGFSIDEDADSKTDSEIDEEDLMAQQDPYSPLLQQQFKDRRMKIMLKEETKAQGESIRDLNITLSNESSSDDKQDQLFAKLLDDATENIPKRIFGTGCDSLSSAWPQEECLLQLTLSEVKETPDQEIVFKNSITNSSSFEEANEICVRIDQKMAEEEAALGKLLHDLENEANTKVKHDETNSSKESDAARICTSLLDDIMVELTFNEKRWHEKPKSFKFGPIESDDEFSYSFEPQLEKLVPPALEDPARGKSLRECLDTFSDFVSSMADPKLPLMLGRNPTSGVEKIRAAQELLKSKNLAELYADTAESLNSQVAKEIEKRKRRVAASATRCFNQRDKYDDTLELVQNRLMIVKKDSGDLEELPPPPPLISDTESEDYDTAEDEYTPGNGGHKHTHGSKPQDSKEHLMNNLLKQKQDKPDTVEEVGKKNDHDEDEFYSLEAMTTFGNLDAEFFHKLDLQKVNDSEDSESAINCMRSYNELQAYMKSGSLKHQLNSEDTKMLQTMFSTVASDGKPKLRNPKGEEEDDLLKKMVLRMKEYEEREHQLQLVPHEIPRELSPIKLSLGGSKLFEQKNKIPETGLVHAENELTGNIQFIDNKKTNNDKSTDAIEKNCEPLVKTSCQTSNKSIDDDIQSDVSTDYESGEEVLVVEPPKLSDAVLKSLYSDGFEADLKMVHELEEATRRNLYRYHSNVMHNSTNNHSFSTKKTLPTKTSTSEQSVGAKAKWAKIAERLHEFLDPETILRKEQIGERDACEDSEDEDFAFEENNFEKDEKLIISEEYNSTQNICDGNSGPSKLDGSDQFASIKGFENITEMPTYNMELNSQSKKKTSEKLSNEIENIITTCSSFEAPTDSIGIEYFEDPTLTQINPEGLKTEQIECNLQILNEDGDVVVQELSVNAQVSFE
What is the function of this protein?
Cilium-specific protein required for cilia structures.
What are the official names of this protein?
Dynein axonemal assembly factor 1 homolog, Defective transmitter-recycling protein, Leucine-rich repeat-containing protein 50 homolog.
What is the protein family that this protein belongs to?
Belongs to the DNAAF1 family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: RNH2_GEOSM
Sequence: MTGLFPDNPKSPIDLLALEGQALRRGFFRIAGIDEAGRGPLAGPVVAAAVILPPGLLLPGVNDSKQLTEEKREELFDVIHREALAVGVGIGDHALVDRINILQATLSAMRDAVRALSMTPGFLLIDGISNIPMNIPQRTVKKGDSLSLSIASASIIAKVTRDRMMVEYDAQYPGYGFASHKGYGAASHLAAIAELGPCPIHRKTFSGVKEHLPSQPDCDTAGPSTGLFSF
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_HAEIG
Sequence: MSELTTIARPYAKAAFDFAIEQSAVEKWTEMLGFAAAVAEDETVKAYLSSSLSAQKLADTVISICGEQLDQYGQNLIRLMAENKRLSAIPAVFEEFKHHVEEHQAIAEVEVTSAQPLNATQIEKIAAAMEKRLARKVKLNCNVDNALIAGVIVRTEDFVIDGSSRGQLTRLANELQL
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RF3_NOSS1
Sequence: MSTEIQTELHQAVELRRNFAIISHPDAGKTTLTEKLLLYGGAIHEAGAVKARRAQRKATSDWMAMEQQRGISITSTVLQFEYQNCQINLLDTPGHQDFSEDTYRTLAAADNAVMLIDVAKGLEPQTRKLFEVCKLRGLPIFTFINKLDRPGREPLELLDEIEQELGLQTYAVNWPIGMGDRFKGVFDRHKQQIHLFERSAHGSKEARDTTVELGDPRIEELLEEDLYYQLKNDLELLEGVGPELDLDLVHQGKMTPVFFGSAMTNFGVELFLKYFLDYALKPGVHISSVGEVPPTYPEFSGFVFKLQANMDPKHRDRVAFIRVCTGKFEKDMTVNHARTGKIVRLSRPQKLFAQERESIDVAYPGDVIGLNNPGVFAIGDTIYTGQKLEYEGIPYFSPELFATLRNPNPSKFKQFQKGISELREEGAVQIMYSNDEAKRDPIMAAVGQLQFEVVQFRLQNEYGVETILELLPYSVARWVEGGWEALNKVGRIFNTTTVKDSMNRPVLLFRNEWNCQQLQGDHPELKLSAIAPVFSSQTVE
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PFKA2_CANAX
Sequence: MISIVNGTSTLSLVAGSVETLNQAINFYTNILGLSVHSEQNDWTYLSNDDNKMIVKIQLDTKSGLSLDQVNDRRTEIIAKLNVTDWRSLDTTSVLKVQNLVALIETLTTFNYTLQITPNELYPNEVYCVGPIGYIIGFTACDEPLTLVPPLQKSHPKPGLVSNLMSKSGSQSRNIEETKAVRRNIAVMTSGGDSQGMNAAVRAVVRATIFHGSKAFAVQEGYAGLVKGGPEYIKEMKWQDVRGFLSEGGTNIGTARCMEFKERWGRLKGCKNLIDAGIDGLIVCGGDGSLTGADLFRHEWPSLIQELKDKGEITNEQFERHKHLYICGMVGSIDNDMAMTDATIGGYSALERICRAIDYIDATANSHSRAFVVEVMGRHCGWLALMAGIATSADYIFIPEKPASSKDWQDQMCDIVGKHRAQGKRKTIVIVAEGAITSDLKPITSDEVKDVLVDRLGLDTRITVLGHVQRGGTAVAFDRTLATLQGVEAVKAILELTPDVPSPLIAIDENKICRRPLVEAVRITKSVASAIEAKDFEKAMSLRDHEFKEHLANFMAMNTANHEKPTLPREKRKKIAIINIGAPAGGMNSAVYAMATYCMSRGHTPYAIHNGFAGLSRHESVKSIEWIDIEGWNSIGGSEIGTNRQTPEETDIGMIAHYFEKYQFDGLIIVGGFEAFVSLEQLERSRAMYPSFRIPMVLIPATISNNVPGTEYSLGADTCLNSLMEYCDIVKQSASATRGTAFIIDVQGGNSGYIATFASLISGAQASYVPEEGISLQQLEMDINSLREAFAVEQGMTKSGKLIIKSSNASKVLTPHTLADIFNDECHGDFDTKTAIPGHVQQGGLPSPIDRSRGDRFAIRAVQFIEDHCDVLAPYRYELDFPIDDKKILNTAAVLGIKSSRLRFTSIRHLFDFETELGRRMPKTIYWNTIRDISDQLVGRTRLDKP
What is the function of this protein?
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
What are the official names of this protein?
ATP-dependent 6-phosphofructokinase subunit beta, ATP-dependent 6-phosphofructokinase 2, ATP-PFK 2, Phosphofructokinase 2, Phosphohexokinase 2.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM_PSEE4
Sequence: MSRKYFGTDGIRGRVGQFPITPDFMLKLGWAAGMAFRKQGHCRVLVGKDTRISGYMFESALEAGLSAAGADVMLLGPMPTPAIAYLTRTFHAEAGIVISASHNPHDDNGIKFFSGSGTKLPDEVELMIEELLDQPMTVVESGKLGKVSRINDAAGRYIEFCKSSVPSSTNFEGLKIVVDCAHGATYKVAPSVFRELGAEVTVLHASPDGLNINENCGSTHIESLQAAVLVGHADLGIAFDGDGDRVLMVDHTGAIVDGDELLYIIGRDLHDRNKLQGGVVGTLMSNLGLELAFKELDIPFVRAKVGDRYVMAELLEREWLLGGENSGHVVCCNHTTTGDAIIAALQVLMALKRKGETLAQARQGVRKCPQVLINVRFEAGKSDPLQNPLVKEASDKATEAMAGRGRVLLRKSGTEPLVRVMVEGDDENQVRGHAEALAKLVAEVCA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MURG_BORGP
Sequence: MSNKKRIFFTGGGTGGHVFPGISIIQKLKELDNEIEFFWIGKKNSIEEKLIKEQNNIKFIWVPCGKLRRYFSFQNFTDFFKVILGIIKSFYVLKKYKPQIVYATGGFVSTPTIIASSLLKIKRITHEMDLDPGLATKINSKFANKIYTSFKESEKYFKNHKNIIYTGSPIRKEFLTPNPKIIKQLTQNTNKPIVSVLGGSLGANALNNLALFIKKYAEIYFIHQSGKNLNDLREDNYLRRQFFNAEEMASIEKFSNIIISRAGAGAIKEFANACTCVILIPFKKGSRGDQIKNAKLLKNQNACIYIDEDEILNTNILKVIKETLNDREKINSLKENIKKFNNKHSSTLIAKLLIEDIKETKSK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: BUL1_YEAST
Sequence: MAKDLNDSGFPPKRKPLLRPQRSDFTANSSTTMNVNANTRGRGRQKQEGGKGSSRSPSLHSPKSWIRSASATGILGLRRPELAHSHSHAPSTGTPAGGNRSPLRRSTANATPVETGRSLTDGDINNVVDVLPSFEMYNTLHRHIPQGNVDPDRHDFPPSYQEANNSTATGAAGSSADLSHQSLSTDALGATRSSSTSNLENLIPLRTEHHSIAAHQSTAVDEDSLDIPPILDDLNDTDNIFIDKLYTLPKMSTPIEITIKTTKHAPIPHVKPEEESILKEYTSGDLIHGFITIENKSQANLKFEMFYVTLESYISIIDKVKSKRTIKRFLRMVDLSASWSYSKIALGSGVDFIPADVDYDGSVFGLNNSRVLEPGVKYKKFFIFKLPLQLLDVTCKQEHFSHCLLPPSFGIDKYRNNCKYSGIKVNRVLGCGHLGTKGSPILTNDMSDDNLSINYTIDARIVGKDQKASKLYIMKEREYNLRVIPFGFDANVVGERTTMSQLNDITKLVQERLDALRKIFQRLEKKEPITNRDIHGADLSGTIDDSIESDSQEILQRKLDQLHIKNRNNYLVNYNDLKLGHDLDNGRSGNSGHNTDTSRAWGPFVESELKYKLKNKSNSSSFLNFSHFLNSSSSSMSSSSNAGKNNHDLTGNKERTGLILVKAKIPKQGLPYWAPSLLRKTNVFESKSKHDQENWVRLSELIPEDVKKPLEKLDLQLTCIESDNSLPHDPPEIQSITTELICITAKSDNSIPIKLNSELLMNKEKLTSIKALYDDFHSKICEYETKFNKNFLELNELYNMNRGDRRPKELKFTDFITSQLFNDIESICNLKVSVHNLSNIFKKQVSTLKQHSKHALSEDSISHTGNGSSSSPSSASLTPVTSSSKSSLFLPSGSSSTSLKFTDQIVHKWVRIAPLQYKRDINVNLEFNKDIKETLIPSFESCLCCRFYCVRVMIKFENHLGVAKIDIPISVRQVTK
What is the function of this protein?
Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1.  The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2.
What are the official names of this protein?
Ubiquitin ligase-binding protein BUL1, Respiration deficiency suppressor 1.
What is the protein family that this protein belongs to?
Belongs to the BUL1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UREE_SYNPV
Sequence: MSDNVSDHKPIVLEHRQVGEAVGDFPPDRRLQLPLTAEERTVLRGRRCSDCGLSLLLQLPREGPLQPGDRLLDRSRSWEVVVIAAPEPLLRVQADSVLELLQAAYHLGNRHVALELHDGELLLLKDSVLEAMLRSRGLRVSACERPFLPEGGAYGGSPSHAHRHSHVHSHSHETP
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATK_GALNI
Sequence: MEELQGYLEKDRSRQQHFLYPLLFQEYIYALAHDYGLNGSIFYESAEVFGYDNKSSLALVKRLITRIYQQKSLIYLVNNSKQNRFVGHTHNNFFYSQMISESFSIIVEIPFSLRLVSYLKEKEIPKYHNLRSIHSIFPFLEDKLSHLNYVSAILIPHPIHMEILVQILQCWIQDVPFLHLLRFFLHEYHNWNSFLITQKKSIFVFSKEKKRLFRFIYNFYVFECEFLFVFIRNQSSYLRLTSFGTFLERTHFYGKIEHLQIEKLIVICRNDFHRTFWFFKDPFMHYVRYQGKAILASKGTHLLMTKWKYHFVNFWQYYFNFWSQPYRIQINQLSNYSFYFLGYLSSLLINSSAVRNQMLENSFIIDTLTKKFDTIVPVILLIGSLSKAKFCTISGHPISKPIWANLSDSDILDRFGRICRNLFHYHSGSSKKQGLYRIKYILRLSCARTLARKHKSTVRTFLRRLGSGLLEEFFTEEEEVLSLMFPKTTSYTLHGSHRERIWFLDIIRINDLVNRS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRPA_PARPJ
Sequence: MSRIKNTFAALSAQGKKGLIPFMTAGDPDPARTVEFMHALAAGGADVIELGVPFSDPMADGPVIQQSSERALAHGVSLRHVIADVKRFRETNDTTPVVLMGYANPIERMGTEAFAKAAKEAGVDGVLVVDYPPEECANFAEQMQSAGIDPIFLLAPTSTDERIAEVGKIASGYVYYVSLKGVTGAANLDVSSIASKIPAIKSRVPLPVGVGFGIRDAQTARSVAEVSDAVVIGSRIVQLLEQAAPEAAAETLTRFVAEVREALDSVATAR
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: DNLJ_XANC8
Sequence: MTASPDPAQRIDALRQRIEDANYRYHVLDEPQIADVEYDRLLRELEALEAAHPELATADSPTQRVGYLAASRFAEVRHVLPMLSLGNAFSDEEVAEFVRRISERLERKQPVFCAEPKLDGLAISLRYEQGEFVQGATRGDGATGEDVSANLRTVKAIPLRLRGTGWPEVLEVRGEVYMPRAAFEAYNAQMRLQGGKVLANPRNGAAGSLRQLDARITAQRPLSFFAYGVGEVADGALPPTHSTMLAQLREWGFPVSQLVEVVQGSEGLLTYYRRIGEARDGLPFDIDGVVYKLDDLAGQREMGFVSRAPRWALAHKFPAQEQSTTVEAIEIQIGRTGAATPVARLKPVHVAGVVVTNATLHNADQIARLDVRVGDTVIVRRAGDVIPEVAGVVAEQRPAGTHAWQMPTQCPVCGSEIVREEGQAVWRCSGELTCPAQRKEAFRHFVSRRAMDVDGLGEKFIEVLVDSGVVQGVADLYLLNVDQLLQLRLISTADSPHAFLREAREHLAAGAYAQVEQTMVGIGVDLAGVQPAPQTWQADLLRAGLPAFDWNRKKIATKWAENLIEAIETSRDTTLERFLFALGIEHVGESTAKALSAWFGELDVIRHLPWPLFKRVPDIGGEVARSLGHFFDQAGNQQAIDDLLQRGVRIGDAHPPSPKLRGALSFAVLLEDLDIPKVTPVRAQQLAAATASFDALIASEADPLLQAGVPAPVIASLQQWLARPENAALATAAQRAMDALLAQLPQADAVQAGPLDGQTVVITGTLAALTRDAAKQRLESLGAKVAGSVSKKTAFLVAGEEAGSKLDKAQSLGVEIWDEARLLAFLSEHGQAV
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: KLRD1_MOUSE
Sequence: MAVSRITRWRLMSVIFGIKCLFLMVTLGVLLINSFTIQNIQSTPSPTTTVEFQEVSECCVCLDKWVGHQCNCYFISKEEKSWKRSRDFCASQNSSLLQPQSRNELSFMNFSQTFFWIGMHYSEKRNAWLWEDGTVPSKDLFPEFSVIRPEHCIVYSPSKSVSAESCENKNRYICKKLPI
What is the function of this protein?
KLRD1-KLRC2 acts as an immune activating receptor.  On cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal sequence-derived peptides from non-classical MHC class Ib MHC-G molecules, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy.  Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection.  Upon MHC-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.
What are the official names of this protein?
Natural killer cells antigen CD94, Killer cell lectin-like receptor subfamily D member 1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: K1C18_XENTR
Sequence: MSYSRSVYSSSSVVGGSPYRSLSSAPRFIPSSSAASVHAGAGGSGARISVSRVSSVGSGFGGGYSGVSNVNLIGGGQNEKETMQDLNDRLASYLERVRSLEAANKKLEVQIRQHTEKKGPSKDWSPYYKTIEDLRKQVFDSTLENSQLVLQIDNARLAADDFRVKYEAEMAIRMSVEGDITGLRKLIDDTNVSRMNLENEIESLKEELIFLKKNHQDDVTELQAQVARSAVTVEVDAPKSQDLGKIMTELRAQYDGLAQKNRDDVEKWYQSKVDEHTVQVNLDTEALHSAKSSVTDLRRTVQSLEIELESLRNQKASLEGTLHDTEARYAMELEMLGGTAMAMEAELVQVRSDCQRQQQEYQALLNTKMKLEAEIHTYRRLLEGDGSFDLQDAVPTVTTQTVKKVITTTQRIVDGKVVSESNDTEVLKS
What is the function of this protein?
When phosphorylated, plays a role in filament reorganization.
What are the official names of this protein?
Keratin, type I cytoskeletal 18, Cytokeratin-18, CK-18, Keratin-18, K18.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.
Protein: PROB_BRADU
Sequence: MASPELSQFRRIVVKVGSALLVDSDKGEVRTSWLAALADDMAKLHKEGRDVLVVSSGSIALGRSRLKLPRGPLKLEESQAAAAVGQIALARIWSEVLGAHGIDAGQILVTLQDTEERRRYLNARSTIGKLLEWRAIPVINENDTVATTEIRYGDNDRLAARVATMASADLLVLLSDIDGLYDAPPKNNPNAKLIPVVDSISSEIEAVAGDAESELSRGGMRTKVEAAKIATTGGTHMLIASGKIEHPLQAIANGGRCTWFLTPANPITSRKRWIAGTLEPKGTLTIDAGAVTALRAGASLLPAGVIKVEGQFARGDAVIVRGPDTSEIGRGLIAYDADDAERIKGRSSPDVMTILGISGRAEMIHRDDLVVGG
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_SELME
Sequence: MALNLRKNHPLLKIINDSLIDLPTPSNISIWWNFGSLLGICLITQIITGLLLATHYTADTSLAFNSVAHMCRNVQFGWLIRNLHANGASLFFICIYLHIGRGFYYGSYLNKETWNIGVILLLILMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFVIAGLTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYSIKDILGFALMLISLAALALFSPNLLGDPENFTPANPLATPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPLLHTSKQRSMTFRPLSQILFWILVTNLLILTWVGSQPVEHPFIIIGQLASFSYFTIILVLFPIVSVLENKLLNL
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CMOA_ECO81
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAEDAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: RAPA_PSESM
Sequence: MAQQYQPGQRWISDSEAELGLGTVLAQDGRLLTVLYPATGETRQYALRNAPLTRVRFSPGDVITHFENWKMTVREVDDVDGLLVYHGLNAQNEVVTLPETQLSNFIQFRLATDRLFAGQIDQLSWFSLRYNTLEHTSRQLQSSLWGLGGVRAQPIAHQLHIAREVADRIAPRVLLADEVGLGKTIEAGLVIHRQLLSGRANRVLILVPENLQHQWLVEMRRRFNLQVALFDAERFMESDAGNPFEDTQLALVALEWLVEDEKAQDALFAAGWDLMVVDEAHHLVWHEEKASREYSLVEQLAEVIAGVLLLTATPEQLGQDSHFARLRLLDPNRFHDLKAFRAESENYRPVAQAVQELLDKGKLSAAAQKTIHGFLGAEGDTLLAAVNAGDDEAKARLIRELLDRHGTGRVLFRNTRAAVQGFPERKLHQYPLPCPVEYLELPVGEHADLYPEVSFQSQSDASEEERWWRFDPRVEWLIDTLKMLKRVKVLVICAHAETAMDLEDALRVRSGIPATVFHEGMNILERDRAAAYFADEEFGAQVLICSEIGSEGRNFQFSHHLVLFDLPSHPDLLEQRIGRLDRIGQKHVIELHVPFLETSPQARLFQWYHEALNAFLNTCPTGNALQHQFGPRLLPLLESGDDDEWQSLIDEARSERERLESELHTGRDRLLELNSGGAGEGEALVEDILEQDDQFSLPIYMETLFDAFGIDSEDHSENALILKPSEKMLDASFPLGDDEGVTITYDRNQALSREDMQFITWEHPMVQGGMDLVLSGSMGNTAVALIKNKALKPGTVLLELIYVSEVVAPRSLQLGRYLPPAALRCLLDANGNDLSSRVSFNTLNDQLESVPRASANKFIQAQRDQLTPRINAGEEKITPKHAERVAEAQRRLAADTEEELARLTALQAVNPTVRDSELVALRTQREQGLAMLEKAALRLEAIRVLVAG
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.