PharMolix/UniProtQA huggingface dataset:
Protein: LEUC_GEOTN
Sequence: MKPKTIIEKIWENHVVYREEGKPDLLYIDLHLVHEVTSPQAFEGLRQNGRKVRRPDLTFATMDHNVPTVNRFVITDEVARNQIAALERNCREFGIPLADLHSEEQGIVHVIGPELGLTQPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLWQHKPKTLQIRINGQLGKGVTAKDVILAIIGRYGVGVGTGYIIEFTGEAIRRMSMEERMTICNMSIEAGARAGLISPDETTFAYLRGRKYAPKGEEFDQAVERWRALASDEGAEYDKTIEIDASTIAPMVTWGTNPSMSTSVDGTVPDPEQFESETERNAVRRALEYMGLKPGMSITEIPVQHVFIGSCTNSRISDLREAAKIVKGQKVAPGVRALVVPGSQQVKKQAEEEGLAQIFLDAGFEWRDAGCSACLGMNPDIIPEGEHCASTSNRNFEGRQGKGARTHLVSPAMAAAAAIYGRFVDVRQLEAEPVR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: ASSY_ECOL6
Sequence: MTTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRRGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQVENLENKGQ
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQK9_SCHPO
Sequence: MALELTEHQLNKLRDFLDEILLDVSQKYQKKFHPGGYQKLEELAFDLEPYFQVVSSIPLEKHTFLVTNFTLRGIDFFVDTIVGFPASPETTFKVFSLLDSLCLRLIQSGNLSTTDTIRLKSLMENCRMVVISKLSDVQGYEMDCASIFEKSLNSIDF
What are the official names of this protein?
Uncharacterized protein C1494.09c.
Protein: GET1_PARBA
Sequence: MPSLLISVLFLHIAIYIINTIGASTIDSLLWLIYTKLPTSASCMAREQHQMKLEVVQLKREMNATSSQDEFAKWAKLRRRHDKALEEYEVKNKQFSRFKSLFDVAVKALRWAGTSGLILLLQFWFSKTPIFTLPPSWIPWQVEWVLSFPRAPMGTVSIQVWGGACAVMVALVGEAIGATVRYLYGSKDSMEAIKVGAGAVEKEKKRQ
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein GET1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SECE_STRGB
Sequence: MTDAVGSIDTPDAQDEVPESKKTRKGGKRAKKGPLKRLATFYRQIIAELRKVVWPTRNQLTSYTTVVIFFVAIMIRLVTVIDYGLNHAAKYVFG
What is the function of this protein?
Essential subunit of the Sec protein translocation channel SecYEG.  Clamps together the 2 halves of SecY.  May contact the channel plug during translocation.
What are the official names of this protein?
Protein translocase subunit SecE.
What is the protein family that this protein belongs to?
Belongs to the SecE/SEC61-gamma family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: PDXS_TREDE
Sequence: MDILDKLRGGVIMDVTNPEQAKIAENAGAVAVMALERIPADIRAAGGVSRMSDPKMIKEIIKAVKIPVMAKVRIGHFVEASILEAIGIDFIDESEVLSPADEVYHVDKNKFKVPFVCGARNLGEALRRIQEGAKMIRTKGEAGTGDVIQAVKHMRQIQSEMRQLTCLREDELYVAAKNFQVPYALVEYVHKHGKLPVPNFSAGGVATPADAALMVHLGADGVFVGSGIFKSGDPAKRAAAIVKAVKNYDNPAILAEVSENLGPAMVGINEEEIKVIMSERGV
What is the function of this protein?
Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia.  The ammonia is provided by the PdxT subunit.  Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxS, PLP synthase subunit PdxS, Pdx1.
What is the protein family that this protein belongs to?
Belongs to the PdxS/SNZ family.
Protein: SECA_CAMJD
Sequence: MFLNTLKAVFGTKNDREVKKYFKRVVQINALEGKYQNLSDDELKAEFEKFKEQILSGEKNENDILNDVFAIVRETGKRTLNMRHFDVQLIGGMVLHDGKIAEMKTGEGKTLVATLPVVLNAMSGKGVHVVTVNDYLAKRDAEQMSAIYNFLGFSVGVVLSSQNSDIEHKQAYDCDITYGTNNEFGFDYLRDNMKFSKAEKVQREHNFVIVDEVDSILIDEARTPLIISGPTNRTLDGYIKANEVAKQMQKGEAVLPPEKPEGDFVVDEKNRSVLITEAGIAKAEKLFGVENLYSLENAILAHQLDQALKAHNLFEKDVHYVLRNKEVIIVDEFTGRLSEGRRFSEGLHQALEAKENVKIQEESQTLADITFQNYFRMYNKLAGMTGTAQTEATEFSQIYSLDVISIPTNIPIKRQDKDDLIYKTQNEKFKAVIEEIKKANAKGQPVLVGTASIERSEVFHNMLAKEKIPHHVLNAKNHEQEALIIQDAGKKGAVTIATNMAGRGVDIKIDDEIRALGGLYIIGTERHESRRIDNQLRGRAGRQGDPGISRFYLSLEDNLLRIFGGDRIKSIMDRLGIEEGESIESRIVTRAVENAQKKVESLHFESRKHLLEYDDVANEQRKTIYRYRNELLDENYDIRAKISQNIAEYSANVMNDYMLDESGSNVNFENLKAKILYECSTQISEKDFENLSVIEMQDKLSQILENSYNEKMSRLEIKELRNIERILYLQVLDNVWREHLYQMDILKTGIGLRGYNQKDPLVEYKKESYNLFLELVNRIKFDSIKLLFSVQFNQQEAQNLENKANEENEKLLQSSVEMGASEDNLGEAEFKKVPRNAPCPCGSGKKFKECHGKSGPKQGILA
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: AQ12A_HUMAN
Sequence: MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS
What is the function of this protein?
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
What are the official names of this protein?
Aquaporin-12A, AQP-12.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: YQGF_RICPU
Sequence: MIIKNLQEFYRLLIPNAPLIAIDYGSKKLGIALSNQERSIAMPLNTITEINKKIVITSLLNIIEKYKVCGVIIGLPIDMSGAVTEQTNIVMKFAEELAKSINLPIYLQDERLTTKAANNLLKSFGVKRKDRNNNDDAVAASMILETVLDSIKNI
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL6_SYNR3
Sequence: MSRIGKNPVPIPEKVSVEISGLTVKVKGPKGELERVLPDGVSVSQADNAVTVSPSDTSRRSRERHGLCRTLVANMVEGVSKGFSKKLEIIGVGYRAQVKGKKLVVSAGYSHPVEMDAPEGVTFAVENNTLVTVSGADKELVGNEAAKVRGIRPPEPYKGKGIKYQGERILRKAGKTGKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: DDL_MICAN
Sequence: MDKIKVGLLFGGRSGEHEVSINSARSILQAFNYPENLDKYAVIPFYIDKNGCWHSAATARQILTSGQPLAIESNIKVNIWQFPPEVREMEVWFPILHGPNGEDGTLQGLLTLMRVAFVGSGVLGSCLGMDKIAMKTAFAAAGLPQVKYKAITRSQVWSNPCVFPQLCDQIAEEIGYPCFIKPANLGSSVGISKARNRQELEAALDSAASYDRRIIVEAGVTAREIECAVLGNDNPQASLVGEITFDSDFYDYETKYTDGRSSMVIPANIPDKIANQVREMAVEAFKAVDAAGLSRVDFFYVENTGEVLINEINTLPGFTNFSMYPQLWKATGLEFDKLVDKLVQLALERQEK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL21_PROVB
Sequence: MQALIEISDKQFLVQEGDKIFVPKQKAVAGDVIEVKSLMKVGQADSALSEGTAKVKVLDHVRDETIIVFRKKRRKRFQRRNGHRQHMTQVEVMSI
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: BIPA_ECO27
Sequence: MIEKLRNIAIIAHVDHGKTTLVDKLLQQSGTFDSRAETQERVMDSNDLEKERGITILAKNTAIKWNDYRINIVDTPGHADFGGEVERVMSMVDSVLLVVDAFDGPMPQTRFVTKKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLDATDEQLDFPIVYASALNGIAGLDHEDMAEDMTPLYQAIVDHVPAPDVDLDGPFQMQISQLDYNSYVGVIGIGRIKRGKVKPNQQVTIIDSEGKTRNAKVGKVLGHLGLERIETDLAEAGDIVAITGLGELNISDTVCDTQNVEALPALSVDEPTVSMFFCVNTSPFCGKEGKFVTSRQILDRLNKELVHNVALRVEETEDADAFRVSGRGELHLSVLIENMRREGFELAVSRPKVIFREIDGRKQEPYENVTLDVEEQHQGSVMQALGERKGDLKNMNPDGKGRVRLDYVIPSRGLIGFRSEFMTMTSGTGLLYSTFSHYDDVRPGEVGQRQNGVLISNGQGKAVAFALFGLQDRGKLFLGHGAEVYEGQIIGIHSRSNDLTVNCLTGKKLTNMRASGTDEAVVLVPPIRMTLEQALEFIDDDELVEVTPTSIRIRKRHLTENDRRRANRAPKDD
What is the function of this protein?
A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation.  Binds GTP and analogs.  Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA (By similarity).  GTPase that impacts interactions between enteropathogenic E. coli (EPEC) and epithelial cells and also has an effect on motility (PubMed:9622352).
What are the official names of this protein?
50S ribosomal subunit assembly factor BipA, GTP-binding protein BipA, GTP-binding protein BipA/TypA, Ribosome-dependent GTPase BipA, Tyrosine phosphorylated protein A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Binds to ribosomes.
Protein: ACM2_HUMAN
Sequence: MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
What is the function of this protein?
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.  Primary transducing effect is adenylate cyclase inhibition.  Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
What are the official names of this protein?
Muscarinic acetylcholine receptor M2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization.
Protein: UL92_HCMVA
Sequence: MCDASGACDMRHVQNAFTEEIQLHSLYACTRCFRTHLCDLGSGCALVSTLEGSVCVKTGLVYEALYPVARSHLLEPIEEAALDDVNIISAVLSGVYSYLMTHAGRYADVIQEVVERDRLKKQVEDSIYFTFNKVFRSMHNVNRISVPVISQLFIQLIIGIYSKQTKYDACVIKVSRKKREDALLKQMRSEYGNAPVFGSGV
What are the official names of this protein?
Protein UL92.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL92 family.
Protein: SP20H_MOUSE
Sequence: MQQAVEQALDCAEYIVESAQQRPPKRKYLSSGRKSIFQKLYDLYVEECEKEPEVKKLRRNVNLLEKLVMQETLSCLVVNLYPGNEGYSLMLRGKNGSDSETIRLPYEEGELLEYLDAEELPPILVDLLEKSQVNIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLVCDVHSITSDNHKWTQEDKLLLESQLILATAEPLCLDPSVAVACTANRLLYNRQKMNTRPMKRCWKRYSRSSLNRQQDLSHGPPPPQLRLLDFLQKRKERKAGQHYDLKISKAGNCVDMWKRSPCNLAVPSEVDVEKYAKVEESIKSDDSQPTMWPAHDVKDDYVFECEGGNQYQKTKLTILQSLGDPLYYGKIQPWKADEENDSQMSPSHSSADDHSNWFVIGSKTDAERVVNQYQELVQNEAKCPVKMSHSSSGSAALSPGEEAEQAETSSIQSSVLGKGVKHRPPPIKLPSGSGNSSSGNYFTAQQASSFLKSPTPPPSCKPSLSRKSSVDLSQVSMLSPAALSPASSSQRHES
What is the function of this protein?
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation.  Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail.  Required for starvation-induced ATG9A trafficking during autophagy.
What are the official names of this protein?
Transcription factor SPT20 homolog, p38-interacting protein, p38IP.
What is the protein family that this protein belongs to?
Belongs to the SPT20 family.
Protein: RECA_SYNSC
Sequence: MPADMKSGASDPRPSGERDKALNLVLGQIERNFGKGSIMRLGDASRMRVETISTGALTLDLALGGGYPKGRVVEIYGPESSGKTTLTLHAIAEVQKRGGVAAFVDAEHALDPVYAASLGVDVENLLVSQPDTGEMALEIVDQLVRSAAVDLVVVDSVAALTPRAEIEGEMGDLAVGAQARLMSQAMRKITGNIGKSGCTVIFLNQLRLKIGVTYGNPETTTGGNALKFYASVRLDIRRIQTLKKGTEEFGIRAKVKVAKNKVAPPFRIAEFDILFGRGISTLGCLLDLAEETGVVVRKGAWYSYEGDNIGQGRDNTISWMEENPDATATIETLVRQKLTEGSEVKANSMRPLAAAAKTAAADKSAPAKASEAAA
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: C71B5_ARATH
Sequence: MSIFLCFLLLLPLSLIFLKKLLPSKGKLPPGPKGLPIIGNLHQFGRFLHKSLHKISQEYGPVMLLHFGVVPVIIVSSKEGAEEVLKTHDLETCSRPKTVGSGLFTYNFKDIGFAPYGENWREMRKIAVSELFSQKKLKSFRYIREDESQLLVRKVSKSALETPTSSVNLRKVIFTFAASIICRLSFGQNFCDFVDMETVEELVLESETNLGSLAFADFLPAGWIIDRISGQHSTVMKAFSKLTNFFELVIDDHLKSGKIEDHSDIISVMLDMINKPTEVGSYKVTDDHLKGLMSDVFLAGVNAGSITMIWTMTELSRHPRVMRKLQEEIRAALGPNKEKITEEDLEKVEYLKMVIEEAFRLHPPAPLLLPRLTMSDINIQGYSIPKNTMIQINTYTIGRDPKNWTKPDEFIPERFVDNPIEYKGQHFELLPFGAGRRVCPGMATGITIVELGLLSLLYFFDWSLPNGMTTKDIDMEEDGAFVIAKKVSLELVPTLHRW
What are the official names of this protein?
Cytochrome P450 71B5.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: NAC8_ARATH
Sequence: MAGRSWLIDSNRIATKIMSASASSDPRQVVWKSNPSRHCPKCQHVIDNSDVVDDWPGLPRGVKFDPSDPEIIWHLLAKSGLSGLSSHPFIDEFIPTVNQDDGICYTHPKNLPGVKSDGTVSHFFHKAIKAYSTGTRKRRKIHDDDFGDVRWHKTGRTKPVVLDGVQRGCKKIMVLYGGKAVKTNWVMHQYHLGIEEDEKEGDYVVSKIFYQQPQQLVVKRGDKAEQEVSEDIFAAVTPTADPVTPKLATPEPRNAVRICSDSHIASDYVTPSDYVSAHEVSLAETSEVMCMEDEVQSIQPNHERPSSGPELEHGLENGAKEMLDDKEEQEKDRDNENQGEEDPTWFDSGSQFILNSQQLVEALSLCDDLLGSQDREENTNSGSLKDKQPCIADYAHLGPEDFKRDLEECQKIVLDPSNIELDTPPEFRLSQLEFGSQDSFLAWGTGKTD
What is the function of this protein?
Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833).  Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150).  Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833).  Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300).  Functional homolog of animal p53 (PubMed:24736489).  Regulates SMR5 and SMR7 transcription (PubMed:24399300).  Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress.
What are the official names of this protein?
SUPPRESSOR OF GAMMA RESPONSE 1, NAC domain-containing protein 8, ANAC008, Protein SOG1, SUPPRESSOR OF GAMMA RADIATION 1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RHG26_HUMAN
Sequence: MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSVAGFVWFSVAAVVLSLARSSLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL
What is the function of this protein?
GTPase-activating protein for RHOA and CDC42.
What are the official names of this protein?
Rho GTPase-activating protein 26, GTPase regulator associated with focal adhesion kinase, Oligophrenin-1-like protein, Rho-type GTPase-activating protein 26.
What are the subcellular locations of this protein?
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers and cortical actin structures.
Protein: TYSY_FRATW
Sequence: MREYLNFLKYIKENGVLKGDRTGTGTRSIFGYQMRFDLQKGFPLVTTKKIHIPSVVHELLWFLSGSTNIKYLNDNNVRIWNEWATVDGELGPIYGKQWRDFNGQGIDQIADVIQMLKTNPNSRRILVSAWNPCVVPSEKISPQENVVKGNSALPPCHAMFQFYVANNKLSCMLTQRSADAFLGVPFNIASYSLLTHMVAQQCNLDVGEFIWSGGDCHIYNNHIEQVNEQLSREPLALPTLKILRKPNSIFDYKYEDFEFENYNHHPAIKAKISV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RISB_STRPI
Sequence: MNTYEGNLVANNIKIGIVVARFNEFITSKLLSGALDNLKRENVNEKDIEVAWVPGAFEIPLIASKMAKSKKYDAIICLGAVIRGNTSHYDYVCSEVSKGIAQISLNSEIPVMFGVLTTDTIEQAIERAGTKAGNKGSECAQGAIEMVNLIRTLDA
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: MNME_ECO45
Sequence: MSDNDTIVAQATPPGRGGVGILRISGLKAREVAETVLGKLPKPRYADYLPFKDADGSVLDQGIALWFPGPNSFTGEDVLELQGHGGPVILDLLLKRILTIPGLRIARPGEFSERAFLNDKLDLAQAEAIADLIDASSEQAARSALNSLQGAFSARVNHLVEALTHLRIYVEAAIDFPDEEIDFLSDGKIEAQLNNVIADLDAVRAEARQGSLLREGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDGMPLHIIDTAGLREASDEVERIGIERAWQEIEQADRVLFMVDGTTTDAVDPAEIWPEFIARLPAKLPITVVRNKADITGETLGMSEVNGHALIRLSARTGEGVDVLRNHLKQSMGFDTNMEGGFLARRRHLQALEQAAEHLQQGKAQLLGAWAGELLAEELRLAQQNLSEITGEFTSDDLLGRIFSSFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYO1D_DANRE
Sequence: MAEHESLEFGKADFVLLDNVSLEEFMANLKLRFEKGRIYSYIGEVVVSVNPYRAMNIYGRDVIEQYKGRELYERPPHLFAIADAAYKAMKRRNKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIFQQEGERSFHSFYQLVKGAPDAQLRSLHIQRDPTAYNYIKVGGQLKSSINDSAEFKAVADAMKVIGFTTEEIQTVYKILATILHLGNLKFGTDGDVTLIENSKLVSVLGDLLSTKEENVEKAMLYRTVATGRDVIDKQHTHQEASYGRDALAKAIYERLFCWIVGRINDIIEVKNYDARVHGKNTVIGVLDIYGFEIFQNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHKGIFAVLDEACMNVGKVTDEMFLQALNGKLAKHAHYTSRKLSPTDKNLEFERDFRIRHYAGDVTYSVVGFIDKNKDTLFQDFKRLLYNSSNPVLKAMWPEGKLSITEVTKRPLTAATLFKNSMISLVEKLASKEPYYVRCIKPNDVKSPLLFEHERCKHQVEYLGLLENVRVRRAGFANRQTYPRFLQRYKMISEFTWPNHDLSSDKEAVKRLLQGCGFEHDVAYGKTKVFIRTPRTIFSLEEQRAEMVKRIVLFLQKVWRGTLARMRYRRMRAALIIIRAYRRYKVKSYIREVIRRFKNVRDMKDHGKHVKWPTPPKVLRKFEEALRSIYNRWWAWTLIKPLSPEKTVQIRAKVATLECLKGQRADLGLQRAWEGNYLKKDSPGTASSFTLVSSDLQRKDKFMRVLFSSNVRKINRFNKAEDRALLITDRHLYKMDPLKQYKPMKSIPLYNVTGVSISPGKDQLVVFHTKDNRDLIVCLQGMVPAGDSRIGELVGTLLSHFKSEKRKLQVNTVSPIHCSMNGRKCTVVVETKISQSQPDFTKSRSGYILSVPGN
What is the function of this protein?
Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity).  Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis (PubMed:29769531, PubMed:30139971).  Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle (PubMed:30139971).  Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric development (PubMed:29769531).  Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity).  Required for normal planar cell polarity in ciliated cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement (By similarity).
What are the official names of this protein?
Unconventional myosin-Id, Myosin 1d, Myosin1D.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm. Perikaryon. Cell projection, dendrite. Early endosome. Cytoplasm, cell cortex. Note=Colocalizes with the actin cytoskeleton in the cell cortex close to the apical cell membrane. Colocalizes with cytoplasmic puncta that are reminiscent of transport vesicles.