PharMolix/UniProtQA huggingface dataset:
Protein: ACCA_BURCM
Sequence: MKTTFLDFEQPIAELEAKIEELRFVQDDSAVDISEEIERLSKKSQQLTKDLYANLSPWQVSQIARHPQRPYTLDYVAELFTDFHELHGDRAFADDLSIVGGLARFGGHPCMVIGHQKGRDTKERAARNFGMPRPEGYRKAERLMRLAEKFGLPIFTFVDTPGAYPGIGAEERGQSEAIGRNLYVMAELKTPIITTVIGEGGSGGALAIAVADTVMMLQFSTYSVISPEGCASILWKSAAKAPEAAEALGLTAHRLKALGLIDKIINEPLGGAHRDPKGMAALLRRALADSLRQFQGMSIDALRERRFERLMAYGKFKETTPGA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBP_NOSSH
Sequence: MLKINRKYAIILAIVAFSSFQTEAKAASISMLGTASNFGVLGGSTVTNTGPSVITESLGVSTGSSATGFPPAIVNGTIFTSDTVAAQAQVDNATAYNKLASLIPNKDLTGLDLGGLTLTPGVYSFSSSAQLTGILTLDNLGDPNALFVFQIGSTLTTASNSSIVTTNGDAPNVFFQIGSSATLGTGTQFMGNILALTSITLTTGVNIDCGRALAQNGAVTMDTNKVSNACYTKPQEKAVVPEPDSSLAVLGSGLVSLLFAFRKRFRKGW
What is the function of this protein?
A probable ice-binding protein that has ice-structuring activities in vitro.  Thought not to anchor the cyanobacterium to ice surfaces, as its habitat is shallow puddles fed by glacier meltwater.
What are the official names of this protein?
Ice-binding protein, nIBP.
What is the protein family that this protein belongs to?
Belongs to the ice-binding protein family.
What are the subcellular locations of this protein?
Cell outer membrane; Single-pass membrane protein. Note=An ice-binding activity is found in the supernatant and on the surface of clumps of these cells. Only about 80% of the cells are this strain of Nostoc, so other proteins may be contributing to ice binding. Probably anchored to the outer membrane by its PEP C- terminal signal.
Protein: RL30_PSEFS
Sequence: MATVKVTLIKSMTGRIPNHKLCVKGLGLRRIGHTVEVQDTPENRGMINKAYYMLRVEG
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: HFQ_VIBA3
Sequence: MAKGQSLQDPFLNALRRERIPVSIYLVNGIKLQGQIESFDQFVILLKNTVNQMVYKHAISTVVPARAVSHHSGEQQRAPSDRPEKTED
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: FKBA_ECO57
Sequence: MKSLFKVTLLATTMAVALHAPITFAAEAAKPATTADSKAAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKDQLIAGVQDAFADKSKLSDQEIEQTLQAFEARVKSSAQAKMEKDAADNEAKGKEYREKFAKEKGVKTSSTGLVYQVVEAGKGEAPKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPGIPPNSTLVFDVELLDVKPAPKADAKPEADAKAADSAKK
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
What are the official names of this protein?
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: ACT3_BACDO
Sequence: MCDDEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESSGIHETVYNSIMKCDVDIRKDLYANIVMSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin-3, muscle-specific.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ZPR1_HUMAN
Sequence: MAASGAVEPGPPGAAVAPSPAPAPPPAPDHLFRPISAEDEEQQPTEIESLCMNCYCNGMTRLLLTKIPFFREIIVSSFSCEHCGWNNTEIQSAGRIQDQGVRYTLSVRALEDMNREVVKTDSAATRIPELDFEIPAFSQKGALTTVEGLITRAISGLEQDQPARRANKDATAERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHYNRTRQQEEMLGLQEEAPAEKPEEEDLRNEVLQFSTNCPECNAPAQTNMKLVQIPHFKEVIIMATNCENCGHRTNEVKSGGAVEPLGTRITLHITDASDMTRDLLKSETCSVEIPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPGQTERLQEFSQKMDQIIEGNMKAHFIMDDPAGNSYLQNVYAPEDDPEMKVERYKRTFDQNEELGLNDMKTEGYEAGLAPQR
What is the function of this protein?
Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus.  It is involved in the positive regulation of cell cycle progression (PubMed:29851065).  Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies.  Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons.  Plays a role in the splicing of cellular pre-mRNAs.  May be involved in H(2)O(2)-induced neuronal cell death.
What are the official names of this protein?
Zinc finger protein ZPR1, Zinc finger protein 259.
What is the protein family that this protein belongs to?
Belongs to the ZPR1 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon. Cell projection, growth cone. Note=Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle- dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner.
Protein: LOLB_SALG2
Sequence: MTLPDFRLIRLLPLASLVLTACTLPGHKGPGKSPDSPQWRQHQQEVRHLNQYQTRGAFAYISDDQKVYARFFWQQTGQDRYRLLLTNPLGSTELELNAQPGNVQLVDNKGQRYTADDAEEMIGKLTGMPIPLNSLRQWILGLPGDATDYKLDDQYRLSEVNYRQDGKNWKVVYGGYDSKTQPAMPANMELSDGSQRIKLKMDNWIVK
What is the function of this protein?
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
What are the official names of this protein?
Outer-membrane lipoprotein LolB.
What is the protein family that this protein belongs to?
Belongs to the LolB family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: PGMP_SOLTU
Sequence: MAMESALTSTRVSIPSLCSGISSSHHHHRSLSFLNFPKLSSFKYSFRTISPVPFVVSASSVSPSSPSTSVAQSQDLKIKSVPTKPIEGQKTGTSGLRKKVKVFMQDNYLANWIQALFNSLPLEDYKNGLLVLGGDGRYFNREAAQIIIKIAAGNGVGKILVGKDGILSTQAVSAVIRKREANGGFIMSASHNPGGPEYDWGIKFNYSSGQPAPESITDKIYGNTLSISEIKIADIPDVDLSQLGVTKYGNFSVEVVDPVADYLELMENVFDFSLIRSLVSRPDFRFVFDAMHAVTGAYAKPIFVDKLGASLESIANGVPLEDFGHGHPDPNLTYAEDLVNILYGENGPDFGAASDGDGDRNMILGRSFFVTPSDSVAIIAAQCQYAIHYFQSGPKGLARSMPTSGSLDRVAQKLNLPFFEVPTGWKFFGNLMDAGKLSICGEESFGTGSDHIREKDGIWAVLAWLSILAYRNKDKKSGEKLVSVADVVKDHWATYGRNFFSRYDYEECESEGANNMIEYLRDLISKSKAGDKYGSYSLDFADDFAYTDPVDGSVASKQGVRFVFSDGSRIIFRLSGTGSAGATVRIYIEQFEPDVSKHDMDAQIALKPLIDLALSVSKLKDFTGREKPTVIT
What is the function of this protein?
This enzyme participates in both the breakdown and synthesis of glucose.
What are the official names of this protein?
Phosphoglucomutase, chloroplastic, PGM, Glucose phosphomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PSBN_NYMAL
Sequence: METATLVAIFISGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: ILVC_BRUA1
Sequence: MRVYYDRDADVNLIKSKKVVIVGYGSQGRAHALNLKDSGAANVRVALREGSATVQKAQADGFEVMNVADAAKWADLMMMATPDELQADIYRDHIHNNLRDGAAIAFAHGLNVHCGLIEPKKTVDVVMIAPKGPGHTVRGEYQKGGGVPCLIAIHQDASGNAHDLALSYASGVGGGRSGVIETTFKEECETDLFGEQAVLCGGVVELIRTGFEVLVEAGYAPEMAYFECLNEMKLIVDLIYEGGIANMNYSISNTAEWGEYVTGPRIITAETKAEMKRVLKDIQTGKFTSDWMQEWKAGAARFKGIRRLNDAHQIEEVGGKLRAMMPWIEKNKLVDKARN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: SAHH3_DROME
Sequence: MAKMPETTFADLSLADKTAVKKSSIEARRFSDVSTCSFSSTCFTGSSDEEDVSPKDNHQRNSAGGTDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQSAVLIETLVQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQPNLILDDGGDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSVTKNKFDTFYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEVDPICALQAAMDGFRVVRLNEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCSEIDVNGLHTPELTWERVRSQVDHIRWPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFSAPGRYKSDVYLLPKKMDEYVASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYRY
What is the function of this protein?
Might play a role in the regulation of methionine metabolism.
What are the official names of this protein?
Adenosylhomocysteinase-like 2, dAhcyL2, Inactive S-adenosyl-L-homocysteine hydrolase 2, S-adenosylhomocysteine hydrolase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
Protein: NHAA_FRAT1
Sequence: MGASQKNQELIGGLILFSAALLAIVVNNSPLASYYAMLETINVKLGIENLVIDKNLMHWINDGLMAIYFLYIGLEIKREIIVGTLSKPSNIITPAIAAFAGLAMPSLIYLSINHDIKVINGWAIPSATDIAFTLGILALLGTRVPAKLKLLVITIAIFDDIAAIAIIAIFYTKSLSLLSLSLGTLFILAMIICNRIFKINRSSVYVVLGFFAWFCTIKSGVHATLAGFTTALCIPFRENDKDSPANFMEDSLHPWIIYFILPVFAFANAGISFSGISFSILFEPITLGIIWGLFVGKQLGIFSILAVFKKLKWFKLGESFSNLQLYGISLLCGIGFTMSLFIGVLAFNDTHLLNAIKIGVVVGSVLSGFFGYIVLRFIVTNPS
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YJO7_SCHPO
Sequence: MSAPYKNLDRDTKHTHPKLNETERNLNRGWGDVKKEELYEDLAQSDADKQLAEDKMETKYEKSKPAPSD
What are the official names of this protein?
Uncharacterized protein PB16A4.07.
Protein: COAD_STRPM
Sequence: MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFTNVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMNEKT
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y915_RICCN
Sequence: MSVQNICSTKAYDMLISNDNAFLVDVRTREEWQQVGIPHLDNKNKVIFLSWQLNKDFEDNFLSIVNDKIHAIIFFLCRSGYRSFIAANFITNIGYKNCYNISDGFEGNNQDKGWKQNNLPWQF
What are the official names of this protein?
Uncharacterized protein RC0915.
Protein: ACHA_ERICO
Sequence: AIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPENDQPDLSNFMESGEWVIKEARGWKHRVIYACCPSTPYLDITYHF
What is the function of this protein?
Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
What are the official names of this protein?
Acetylcholine receptor subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: RL32_RHOPB
Sequence: MAVPRRKTSPSRRGMRRSADALKTPTYAEDKDSGELRRPHHLDLKTGMYKGRQVLKKKES
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: HSP1_NEOLO
Sequence: MARYRRHSRSRSRSRYRRRRRRRSRGRRRRTYRRSRRHSRRRRGRRRGYSRRRYSRRGRRRY
What is the function of this protein?
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis.  They compact sperm DNA into a highly condensed, stable and inactive complex.
What are the official names of this protein?
Sperm protamine P1.
What is the protein family that this protein belongs to?
Belongs to the protamine P1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: RL3_NATTJ
Sequence: MKKAILGKKVGMTQIFSEEGEVMPVTVVKAGPCSVVQKKVEDTDGYNAVQIGFEDKKENKTKKPEKGHFEKAGVNPKKHLTEFELESMENLEVGQELTVEQFEVGDQIDVTGTSKSKGFQGTIKRFKHSTGPKTHGSRFYRAPGSLGSMDISRVFKGQTLPGRMGGNTVTVQRLEVVDVDKENNLLLVKGAVPGPKKGLLKIVDSVKAKS
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: SAHH_PYRHO
Sequence: MDCGRDYCVKDLSLADEGWKKIDWVSRFMPVLQHIRREFEEKKPFKGVRIAATLHLEMKTAFLLLTLKAGGAEVSAAASNPLSTQDDVVAALAKAGVKVYAIRGESKEQYYEFMHKALDIRPNIIIDDGADMISLVHKERQELLDEIWGGSEETTTGVIRLRAMERDGVLRFSVIAVNDSYMKYLFDNRYGTGQSTWDGVMRATNLLIAGKNVVVVGYGWCGRGIAMRARGLGATVIVVEVDPIKALEARMDGFLVMNMKEAAKIGDIFITATGDIKCIRREHFELMKDGAIMANAGHFDVEIWKPDLEELAVEISNPRPNVTEYKLKDGRRLYLLADGRLVNLVAADGHPAEIMDMSFALQAKAAEYIKDNHGKLEPRVYILPREIDEMVARIKLASMGIEIEELTEEQKKYLESWEHGT
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_COREF
Sequence: MATIANPRDIILAPVVSEKSYGLMEQNVYTFFVARDANKTQIKIAVEEIFGVKVASVNTVNREGKRKRSRSGFGVRKATKRAYVTLREGSDSIDIFNGSVA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: DAPB_SACD2
Sequence: MTTRIAVTGAAGRMGKALIEAVCQSEDAVLGAAIVAPDSSLVGADAGELAGVGKQGVAIVNDLSTVVADFDVLIDFTSPSATVANASVCKAHNKPMVVGTTGFSPAEKAAFEADASTVPTCVASNFSTGVNLCFKLLDIAARVMGNDADIEVYEAHHRHKVDAPSGTALRMGEVLANAVNRDLNEVAVYGREGQTGARDRNTIGFATVRGGDVVGDHTVSFMCEGERVEITHKASSRLSFARGAVRAATWLVEKEPKIYDMQDVLGLK
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPB_GLOVI
Sequence: MQPNNPNQFTEKAWDAIVRTTEVAKEYRQQQLESEHLFKALLDQDGGLAGSIFTKAGVNLTKLGERVEQFINRQPKLTNPGQSVYLGRSLDALLDRAEGFRKEYGDDFISIEHLVLAFAKDVRFGQQILREFSLDEAKLKAVVAQVRGNQKVTSQNPESTYESLDKYGRDLTQLAREGKLDPVIGRDEEIRRTIQILSRRTKNNPVLIGEPGVGKTAIAEGLAQRIVSGDVPESLQGRKLIALDMGALIAGSKYRGEFEERLKAVLNEVTKSEGQIVLFIDEIHTVVGAGATQGAMDAGNLLKPMLARGELRCIGATTLDEYRKYIEKDAALERRFQQVYVDQPTVEDTISILRGLKERYEVHHGVRISDSALVAAAVLSHRYISDRFLPDKAIDLMDEAAAKLKMEITSKPEALDEVDRKILQLEMERLSLAKESDAASRDRLERLEKELADLKEEQRSLNAQWQAEKDIIDQVQAVKEEIDQVNVQIQQAERDYDLNRAAELKYGKLSELQKRLDAADKQLSETQTSGRSLLREEVTEEDIAEIISKWTGIPVSKLVASEREKLLHLEDELHKRVVGQEEAVRIVSEAIQRSRAGLADPNRPIASFIFLGPTGVGKTELAKALASFLFDDENAMVRIDMSEYMEKHSVSRLIGAPPGYVGYDEGGQLTEAVRRRPYAVVLFDEIEKAHNDVFNVLLQVLDDGRITDSQGRTIDFKNAVIIMTSNIGSDAILRLGGNDAYYEQMREEVMRAMQVHFRPEFLNRVDDIIIFRNLRRDQLAAIVKLQIARLEKRLADRKITLKLSEAAIDYIVEAGYDPVYGARPLKRAIQNELVNPLARGLLKGDFNDGDTIFVDIENERPVFRRLSAMPVV
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y707_ENCCU
Sequence: MARKHAIWRFITLIGTVYCSSQVEHYDTFELEPGDQIILFPFIFKGNNIIALSTTRYRDLDRKRTYLVEDVIDFLGSISHVIWNFTVGRIVCADDNRFQRSFDEIMEGYLKEISLDATKIYMKGNKSFGELLEMIYERMFKFNDKRGNYILKYGSDITKKANDMIEDMPHDLDKKKKEEWEVFLNGIKKCGESFRDTEKWRQLIELEKIACNACKEICLDLKEEELMGLFAEGIMRKSLKVKLGEDEISSRGYLEYITISAKVLLGARKEHGGEVMKELVMQMLLGKKGEEIDKRYVDRVAGVVRERQRRREREIEKNMKELLRDEEKAKSKKKGKKKSVGVSEAKEEEKKESGTEEVEASEEVGIPSVEVGGARRKTGKKSKGDQKRFKIHSRVLRWRKSPEKIKEEWDRGSEERWKGRSLEEIKEQKIVHDITGVLELLRSEDADRFFMDAGEHMKGGSERQRMVAIGALETGGQRMTGVVEVGTFKDGDGCPVVYHLRFRPTSIGSIGDVINPGVVEASDVGRVDEGEECEDADKFVYPKGVRFETVKETGSFQIVWKNPSDTSEVLRRLIVYCRPCVI
What are the official names of this protein?
UPF0329 protein ECU07_0070.
What is the protein family that this protein belongs to?
Belongs to the UPF0329 family.
Protein: PHM_DROME
Sequence: MPRISEIAASVGLLLLIGVISVDGLVKEGDYQNSLYQQNLESNSATGATASFPFLMPNVSPQTPDLYLCTPIKVDPTTTYYIVGFNPNATMNTAHHMLLYGCGEPGTSKTTWNCGEMNRASQEESASPCGPHSNSQIVYAWARDAQKLNLPEGVGFKVGKNSPIKYLVLQVHYAHIDKFKDGSTDDSGVFLDYTEEPRKKLAGTLLLGTDGQIPAMKTEHLETACEVNEQKVLHPFAYRVHTHGLGKVVSGYRVRTNSDGEQEWLQLGKRDPLTPQMFYNTSNTDPIIEGDKIAVRCTMQSTRHRTTKIGPTNEDEMCNFYLMYYVDHGETLNMKFCFSQGAPYYFWSNPDSGLHNIPHIEASTL
What is the function of this protein?
Monooxygenase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides.  Produces an unstable peptidyl(2-hydroxyglycine) intermediate.  C-terminal amidation of peptides is required for normal developmental transitions and for biosynthesis of secretory peptides throughout the life.
What are the official names of this protein?
Peptidylglycine alpha-hydroxylating monooxygenase, dPHM.
What is the protein family that this protein belongs to?
Belongs to the copper type II ascorbate-dependent monooxygenase family.
What are the subcellular locations of this protein?
Secreted.
Protein: IF2B_YEAST
Sequence: MSSDLAAELGFDPALKKKKKTKKVIPDDFDAAVNGKENGSGDDLFAGLKKKKKKSKSVSADAEAEKEPTDDIAEALGELSLKKKKKKTKDSSVDAFEKELAKAGLDNVDAESKEGTPSANSSIQQEVGLPYSELLSRFFNILRTNNPELAGDRSGPKFRIPPPVCLRDGKKTIFSNIQDIAEKLHRSPEHLIQYLFAELGTSGSVDGQKRLVIKGKFQSKQMENVLRRYILEYVTCKTCKSINTELKREQSNRLFFMVCKSCGSTRSVSSIKTGFQATVGKRRRM
What is the function of this protein?
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.  This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex.  Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex.  In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
What are the official names of this protein?
Eukaryotic translation initiation factor 2 subunit beta, eIF-2-beta.
What is the protein family that this protein belongs to?
Belongs to the eIF-2-beta/eIF-5 family.
Protein: PTK7_DROMO
Sequence: MPIVMDMNMLLMLSLAFTVMAPASASSSRFTQPPQSQAIVENDAADFSCEATGPSGDLHYEWLHNGQQIGYDSRVLQIGSNLRIESVQREDAGDYVCIAASAASGARQASPPAKLSVIFLDAVTVQLLGSNRNELLLKCHVEGASGDEPLQIEWYRDSAKLSSWQNVELQQHRLLVRQPSSADDGLYRCIASNAAARVMSKQGYVYEHLASVAPGSTKCLPKLKRNQKMPESWGKQVFLCRGKRGGSTGMDQSQSLPPSPEGLRIVQGPNDKLIIKEGEPTTLSCLYELPAELQNQRIQLRWRKDGKILRHVELGDAVVPGLALDHGKDALVREDGRLVLHKQNGTLSFNSIIASDAGQYMCQIQLEGHAPVNSAPGALEVIEQLKFMPQPTSKNLELGALGKLHCKAQGTPTPQVQWLRDAANGSLPEHVDDINGTLIFRNVSAEHRGNYTCVASNSQGQINATVAINVVVAPRFSVAPEGPIESSEQGVAVIHCQAIGDPKPTIQWDKDLKYLSENNTDRQRFSFLENGTLEIRNVQAEDEGKYGCTIGNSAGLKREEVRLLVRGNGDGFITEESAGDGFLVTRAVLITMTVALAYIVLVVGLMLWCRYRRQARKARLNELSIKEAGGDQAESGKNTEQEPCLSKQRNGHGKSRTAANGDAQKSDDTACSQQSKASKKSAHIYEQLALPRSGLSELIQIGRGEFGDVFVGKLKASLVAAASPSDKDADTEKQHSNSENGSGASGASGCGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQPQEQAQSESTADLLVMVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATATSSPPPLTTSQLLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVAYPALCKDKYSREYHKHRNTLLPVRWLAPECIQEDEYTTKSDIFAFAVVVWELFNQATKLPHEDLSNEQVVQRSLANTLEWSVAEGTPDGLKEILLSCWLTNPKERPSFSQLGAALSKAMQAAEK
What is the function of this protein?
Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system.  Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage.  Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase-like otk, Tyrosine-protein kinase-like 7 homolog.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.