PharMolix/UniProtQA huggingface dataset:
Protein: RS7_RHOP2
Sequence: MSRRHAAEKREVLPDPKFGNIVVTKFMNSVMYAGKKSVAESIVYGALDLIEAKTKQAPLTVFEQALENVMPAIEVRSRRVGGATYQVPVEVRSTRRQALGIRWLITAARGRNEKTMTERLSAELLDASNNRGNAVKKREDVHKMAEANRAFSHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: LSPA_ECOK1
Sequence: MSQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAIGISVILAVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSKAKKQ
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRE_LEVBA
Sequence: MIPAEQIATDLLTIGAVTLAPNHPFLWASGMQAPIYTDNRRTIAFPQVRTHIADGLASLIKHRYPTATVISGVATAGITHAALVADRLNLPMSYVRAKPKDHGKGKQIEGQMTASDQVVLIDDLISTGGSVLAAAKAVRKAGATVLGVVAIFSYELPDSVVNFQQAGLALTPLTTYSTLITVAQQQAKITAPEMASLRQWREDPWGWVSV
What is the function of this protein?
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
What are the official names of this protein?
Orotate phosphoribosyltransferase, OPRT, OPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
Protein: CYSC_ECO57
Sequence: MALHDENVVWHSHPVTVQQRELHHGHRGVVLWFTGLSGSGKSTVAGALEEALHKLGVSTYLLDGDNVRHGLCSDLGFSDADRKENIRRVGEVANLMVEAGLVVLTAFISPHRAERQMVRERVGEGRFIEVFVDTPLAICEARDPKGLYKKARAGELRNFTGIDSVYEAPESAEIHLNGEQLVTNLVQQLLDLLRQNDIIRS
What is the function of this protein?
Catalyzes the synthesis of activated sulfate.
What are the official names of this protein?
Adenylyl-sulfate kinase, APS kinase, ATP adenosine-5'-phosphosulfate 3'-phosphotransferase, Adenosine-5'-phosphosulfate kinase.
What is the protein family that this protein belongs to?
Belongs to the APS kinase family.
Protein: XFIN_XENLA
Sequence: MEEPKCLQREMYKSVMTENYQCVLSLGYPIRKPEIVSMMEVGEELWSKNDSARPGQKEVEGETPKESDWAAENCKRAQMHKEVLDLDTLAAVKSEPVEEGSNSAKKSHICSHYGKLFSCYAAVVRHQRMHQLQKSHHCPHCKKSFVQRSDFIKHQRTHTGERPYQCVECQKKFTERSALVNHQRTHTGERPYTCLDCQKTFNQRSALTKHRRTHTGERPYRCSVCSKSFIQNSDLVKHLRTHTGEKPYECPLCVKRFAESSALMKHKRTHSTHRPFRCSECSRSFTHNSDLTAHMRKHTEFRNVLNLDSVVGTDPLSSQNVASSPYSCSKCRKTFKRWKSFLNHQQTHSREKPYLCSHCNKGFIQNSDLVKHFRTHTGERPYQCAECHKGFIQKSDLVKHLRTHTGEKPFKCSHCDKKFTERSALAKHQRTHTGEKPYKCSDCGKEFTQRSNLILHQRIHTGERPYKCTLCDRTFIQNSDLVKHQKVHANLPLSDPHTANSPHKCSKCDLTFSHWSTFMKHSKLHSGEKKFQCAECKKGFTQKSDLVKHIRVHTGEKPFKCLLCKKSFSQNSDLHKHWRIHTGEKPFPCYTCDKSFTERSALIKHHRTHTGERPHKCSVCQKGFIQKSALTKHSRTHTGEKPYPCTQCGKSFIQNSDLVKHQRIHTGEKPYHCTECNKRFTEGSSLVKHRRTHSGEKPYRCPQCEKTFIQSSDLVKHLVVHNGENPPAATAFHEILIRRENLTRSEPDPYPCTECGKVFHQRPALLKHLRTHKTEKRYPCNECDKSFFQTSDLVKHLRTHTGERPYHCPECNKGFIQNSDLVKHQRTHTGERPYTCSQCDKGFIQRSALTKHMRTHTGEKPYKCEQCQKCFIQNSDLVKHQRIHTGEKPYHCPDCDKRFTEGSSLIKHQRIHSRIKPYPCGVCGKSFSQSSNLLKHLKCHSEQNPPVALSSELGFVAETQTHPDPVDHIVYGDTASYISPEAAGERSFKCNDCGKCFAHRSVLIKHVRIHTGERPYKCSQCTRSFIQKSDLVKHYRTHTGERPYKCGLCERSFVEKSALSRHQRVHKNESPVLNSAMEQQQVTYWGESKDDPNSLVPQLHVIKEEESPHIVNAYSPLSILQSYFPPILEPKGTPRYSCSECGKCFTHRSVFLKHWRMHTGEQPYTCKECGKSFSQSSALVKHVRIHTGEKPYPCSTCGKSFIQKSDLAKHQRIHTGEKPYTCTVCGKKFIDRSSVVKHSRTHTGERPYKCNECTKGFVQKSDLVKHMRTHTGEKPYGCNCCDRSFSTHSASVRHQRMCNTGRPYQDEEYENSLFYSADITWKGDYAQLLQIPCGLEEPMKAIGWISEVAL
What is the function of this protein?
Binds to poly-G sequences in RNA.  May function in post-translational regulation processes.
What are the official names of this protein?
Zinc finger protein Xfin, Xenopus fingers protein, Xfin.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPGH_XANCB
Sequence: MDGTVTLSPAPTDLPPVSSLDAGQPTLPPEAPLAMPEQSLREGSLQVRHQRTSPMGIGLRRFYLIGGTLTATAVAVWVMLSVLWPGGFSVLEGCLLGLFVLLFAWIAMSFASAVAGFITVVARAGRKLGIDPDAPLPSLHTRTALLMPTYNEDPRRLLAGLQAIYESVAETGQLEHFDFFVLSDTTREHIGRAEEQVYAELCDSVGGHGRIFYRRRADNAARKAGNVADWVRRFGGNYPQMLILDADSVMTGDTIVRLVAGMEDNPDVGLIQTLPAVVNGQTLFARMQQFGGRVYGPIIAFGVAWWHGAESNYWGHNAIIRTQAFADHAGLPSLRGRKPFGGHVLSHDFVEAALMRRGGWAMHMVPYLQGSYEEGPPTLTDLLVRDRRWCQGNLQHAKVVGAKGLHWISRMHMMIGIGHYFTAPMWGMLMLVGIGIPLAGAGIDLAQGLPFSPARYWHGSSDGNAIWIFVCTMFVLLAPKLLGYIALLLNPRERRACGGAIRAALSILLETVLAALMAPVVMYLQSRGVFEVLAGKDSGWDAQVRDDGKLSWPALIRSYGGLSVFGLFMGTLAYLVSPSLAAWMAPVIVGMVVSIPVVAVTSLRRTGLALRRAGIFCIPEELDPPKVLVRASELRRAAALEPPLI
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis glucosyltransferase H.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. OpgH subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYS_XANCP
Sequence: MLDPALLRQHPADLAERLRSTRGFDLNTAELESLESERKRIQVRTQELQSLRNSKSKAIGQAKAKGEDVAALMAEVAGFGDELKASEDALDVIRAQLEGIALGIPNLPAANVPAGKDESENVEQARWGTPRQFDFAVKDHVELGAPHGWLDGETAAKLSGARFTVLRGPIARLHRALAQFMLDLHVGEHGYEETNVPLLVNADSMRGTGQLPKFEDDLFQTEVGDSKRYLIPTSEVPLTNIVRDAIVDAERLPLRMTAHSMCFRAEAGSGGRDTRGMIRQHQFEKVELVTACSPEDSEAEHQRMTRCAEVVLEKLGLPYRKVLLCTGDMGFSAIKTYDLEVWLPSQATYREISSCSNCGDFQARRMQARWRNPASGKPELLHTLNGSGTAVGRAMIAVMENYQNADGSIDVPDALRPYMGGLERIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KCNK3_RAT
Sequence: MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAGGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGMGVGVGVGGSGFRNVYAEMLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVSTGLHSLATFRGLMKRRSSV
What is the function of this protein?
pH-dependent, voltage-insensitive, background potassium channel protein.  Rectification direction results from potassium ion concentration on either side of the membrane.  Acts as an outward rectifier when external potassium concentration is low.  When external potassium concentration is high, current is inward.
What are the official names of this protein?
Potassium channel subfamily K member 3, Acid-sensitive potassium channel protein TASK-1, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, Two pore K(+) channel KT3.1.
What is the protein family that this protein belongs to?
Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SH_BRSV3
Sequence: MNSTSTIIEFTGEFWTYFTLVFMMLTIGFFFIVTSLVAAILNKLCDLNDHHTNSLDIRTKLRSDTQLITRAHEESINQSSN
What is the function of this protein?
Viroporin that forms a homopentameric ion channel displaying low ion selectivity.  May play a role in virus morphogenesis and pathogenicity at various stages of the viral life cycle.  Accumulates at the membrane of the Golgi apparatus in infected cells and may facilitate virus release by modifying the secretory pathway.  May enhance host membrane permeability and disrupt cellular ion homeostasis, which can be sensed as damage-associated molecular patterns/danger signals, triggering NLRP3 inflammasome activation and inflammatory immune response.  Also inhibits host TNFA-mediated signaling pathway and may delay apoptosis, allowing time for the virus to replicate.
What are the official names of this protein?
Small hydrophobic protein, Small protein 1A.
What is the protein family that this protein belongs to?
Belongs to the orthopneumovirus small hydrophobic protein family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein. Host Golgi apparatus membrane; Single-pass type II membrane protein. Host endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Present in very small amount in the virion. Detected in lipid rafts of host Golgi apparatus membrane.
Protein: NORR_ECO45
Sequence: MSFSVDVLANIAIELQRGIGHQDRFQRLITTLRQVLECDASALLRYDSRQFIPLAIDGLAKDVLGRRFALEGHPRLEAIARAGDVVRFPADSELPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDGMQPDQFDVFSDEELRLIAALAAGALSNALLIEQLESQNMLPGDAAPFEAVKQTQMIGLSPGMTQLKKEIEIVAASDLNVLISGETGTGKELVAKAIHEASPRAVNPLVYLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVDVRVLAATNRDLREEVLAGRFRADLFHRLSVFPLSVPPLRERGDDVILLAGYFCEQCRLRLGLSRVVLSAGARNLLQHYNFPGNVRELEHAIHRAVVLSRATRSGDEVILEAQHFAFPEVTLPPPEAAAVPVVKQNLREATEAFQRETIRQALAQNHHNWAACARMLETDVANLHRLAKRLGLKD
What is the function of this protein?
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon.  Activation also requires sigma-54.
What are the official names of this protein?
Anaerobic nitric oxide reductase transcription regulator NorR.
Protein: RL3_NEIMF
Sequence: MTLGLVGRKVGMTRVFDEQGVSVPVTVLDMSANRVTQVKSKDTDGYTAVQVTFGQKKANRVNKAEAGHFAKAGVEAGRGLIEFALTEEKLAELKAGDEITVSMFEVGQLVDVTGTSKGKGFSGTIKRHNFGAQRTSHGNSRSHRVPGSIGMAQDPGRVFPGKRMAGQYGNTKATVQKLEVVRVDAERQLLLVKGAVPGAVNSDVVVRPSVKVGA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: PSBH_SYNS9
Sequence: MAQRTRLGDLLRPLNSEYGKVVPGWGTTPVMGIFMVLFLVFLLVILQLYNKSLILEGINVNWNGLG
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly.  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein H, PSII-H.
What is the protein family that this protein belongs to?
Belongs to the PsbH family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PRMC_FRATT
Sequence: MSNITISQLLALSLAKFNQCDISTKHDLQMIICDVLGVDKTYLYINLDKQLDKNTLKKIDEKILRLLAGEPLAYILGYKYFWNQKLYVTKDTLIPRADTETVVATVLDDIQNKDAQLKILDLGTGTGAIALALAAELANSQVVAVDLYQQSLDVAKKNAQANNITNVKFIQSSWYTNLDTDKFDIIVSNPPYIDLADTNIDQSVKDYEPARALFAADNGLADIRIIISQAKDFLNLGGFIYIEHGFTQADAITALFSQCNFTDIKIVKDLNNNDRCTKAQLGYL
What is the function of this protein?
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
What are the official names of this protein?
Release factor glutamine methyltransferase, RF MTase, N5-glutamine methyltransferase PrmC, Protein-(glutamine-N5) MTase PrmC, Protein-glutamine N-methyltransferase PrmC.
What is the protein family that this protein belongs to?
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein: NORM_PHOLL
Sequence: MAKFSNWRELKQLLFFSFPIIVSQIARTAMSFVDIVMSGHYATADLAAVTLGSSIWFPIFVLGYGTIIMLAADVAKQKAQHDDEGIKDSLKNYLFLAVILSIPIIILLMLVSWLLSFIGIDEHILEITQGYVIALACGVPSVMIFNVFRSFLQGLEDTKIAMYLSAGALLLNIPLNYILIYGKLGLPEMGGIGAGITTAIINNLIAVCLIIYFLLKKEYRRYRPDFSLPKYNSLIRTFYIGMPSGLALFVEMVFLDVIAITAAPLGAQVIAAHNIMLNITSIIYTITGGIAAAVTVRVGSYIGKRDKISLTGTIKISIALILSISAVIGVLIYYFAGSFISLYTNDNGVIIIALNIIFLLCLFQFFDSCQAALSGILRGFHDTRSVFYAPLFGYWLVGLPLGFILALTDWVTERMGIIGFWYGLVLGLFVNAILLFIILKVRQRGMISRLISY
What is the function of this protein?
Multidrug efflux pump.
What are the official names of this protein?
Probable multidrug resistance protein NorM, Multidrug-efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: S5A2_MACFA
Sequence: MQVQCQQSPVLAGSATLVALGALVLYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCVHYFHRTFVYSLLNRGRPYPAVLIFRGIAFCAGNGFLQSYYLIYCAEYPDGWYTDIRFCLGVFLFILGMGVNIHSDYILRQLRKPGEITYRIPKGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSVCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
What is the function of this protein?
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids.  It plays a central role in sexual differentiation and androgen physiology.
What are the official names of this protein?
3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, S5AR 2.
What is the protein family that this protein belongs to?
Belongs to the steroid 5-alpha reductase family.
What are the subcellular locations of this protein?
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: COBQ_METM6
Sequence: MAKFIMVVGTSSNSGKTVLVSGICRMLSNKGYKVAPFKSQNMSLNSRVSIEDGEIAVAQYTQAMAARAEPSIHFNPILLKPKGNFVSQVIVHGIPYEDRDYNEYRSKKDVLLEKIKESIEYLDKNYDYVVIEGAGSCCEINLLKDDIANLRIAEISGADAILVSDIDRGGVFAAIYGTVKLLPENWRKLLKGFVINKFRGNLDVLKDGFEKIEELTNIPVIGTIPYDETLILPEEDSQALEGKRVFGNVKSPIEVNIVKFSKIANFTDVDPLSSDCLMKYIDFNDDITGDILILPGTRCSTVEMDLMKKHGMDKKIMEFVENGGIVLGICGGYQTLGKILIDENFSEGDVGTISGLGLFDMETTFGNKKAIKNSTGTISIFDQNFDVMGYELHEGHSISNETPLISLSRGFGNCGDSYDGSFKVIGDSYIFGTYFHGILENFEFRNYLVNIVNNKKNLSRIENDNYAEIFNENMDKLSKLIEENLDLSKIIK
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Probable cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: FLIW_BORBU
Sequence: MIDEKSIEFDFPEGILGFENIKKFIIKDSKYKPFSIMQSINKDVSFLVTSPFNFLSEYLPNIQEKDWSDIKAKEEDEKVILCIINMHVNDYKDITANLKAPIIINKKKLLGKQAICTNEKYSLHHKVFKE
What is the function of this protein?
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin.  Binds to flagellin and participates in the assembly of the flagellum.
What are the official names of this protein?
Flagellar assembly factor FliW.
What is the protein family that this protein belongs to?
Belongs to the FliW family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTAS_CLOAB
Sequence: MDLIESIWECAKQDKKRIILAEGEEKRNLIAADKIIKEGLAELVLVGDENKIKEKASELNLDISKAEIMDPETSLKTETYARDFYELRKHKGMTIEKSEKMVRDPLYFATMALKDGYVDGMVSGAVHTTGDLLRPGLQIIKTAPGVKIVSGFFVMIIPDCDYGEEGLLLFADCAVNPNPTSDELADIAITTAETARKLCNVEPKVAMLSFSTMGSAKGEMVDKVKNAVEITKKFRPDLAIDGELQLDAAIDSEVAALKAPSSNVAGNANVLVFPDLQTGNIGYKLVQRFAKAKAIGPICQGFAKPINDLSRGCSSEDIVNVVAITVVQAQRGI
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
Belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: I18RA_MOUSE
Sequence: MLCLGWVFLWFVAGEKTTGFNHSACATKKLLWTYSARGAENFVLFCDLQELQEQKFSHASQLSPTQSPAHKPCSGSQKDLSDVQWYMQPRSGSPLEEISRNSPHMQSEGMLHILAPQTNSIWSYICRPRIRSPQDMACCIKTVLEVKPQRNVSCGNTAQDEQVLLLGSTGSIHCPSLSCQSDVQSPEMTWYKDGRLLPEHKKNPIEMADIYVFNQGLYVCDYTQSDNVSSWTVRAVVKVRTIGKDINVKPEILDPITDTLDVELGKPLTLPCRVQFGFQRLSKPVIKWYVKESTQEWEMSVFEEKRIQSTFKNEVIERTIFLREVTQRDLSRKFVCFAQNSIGNTTRTIRLRKKEEVVFVYILLGTALMLVGVLVAAAFLYWYWIEVVLLCRTYKNKDETLGDKKEFDAFVSYSNWSSPETDAVGSLSEEHLALNLFPEVLEDTYGYRLCLLDRDVTPGGVYADDIVSIIKKSRRGIFILSPSYLNGPRVFELQAAVNLALVDQTLKLILIKFCSFQEPESLPYLVKKALRVLPTVTWKGLKSVHASSRFWTQIRYHMPVKNSNRFMFNGLRIFLKGFSPEKDLVTQKPLEGMPKSGNDHGAQNLLLYSDQKRC
What is the function of this protein?
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:11046021, PubMed:15843532, PubMed:9792649).  May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity).
What are the official names of this protein?
Interleukin-18 receptor accessory protein, IL-18 receptor accessory protein, IL-18RAcP, Accessory protein-like, AcPL, CD218 antigen-like family member B, IL-1R accessory protein-like, IL-1RAcPL, Interleukin-18 receptor accessory protein-like, Interleukin-18 receptor beta, IL-18R-beta, IL-18Rbeta.
What is the protein family that this protein belongs to?
Belongs to the interleukin-1 receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: CMOA_SHIF8
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHKAGFEHSELWFQCFNFGSLVALKAEDAA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: SCN1A_HUMAN
Sequence: MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK
What is the function of this protein?
Mediates the voltage-dependent sodium ion permeability of excitable membranes.  Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.  Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons.  Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.
What are the official names of this protein?
Sodium channel protein type 1 subunit alpha, Sodium channel protein brain I subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1.
What is the protein family that this protein belongs to?
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSTB1_STRR6
Sequence: MTDAILQVSDLSVYYNKKKALNSVSLSFQPKEITALIGPSGSGKSTLLKSLNRMGDLNPEVTTTGSVVYNGHNIYSPRTDTVELRKEIGMVFQQPNPFPMTIYENVVYGLRINGIKDKQVLDEAVEKALQGASIWDEVKDRLYDSAIGLSGGQQQRVCVARVLATSPKIILLDEPTSALDPISAGKIEETLYGLKDKYTMLLVTRSMQQASRISDKTGFFLDGDLIEFNDTKQMFLDPQHKETEDYITGKFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 1, ABC phosphate transporter 1, Phosphate-transporting ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: GARL_ECO57
Sequence: MNNDVFPNKFKAALAAKQVQIGCWSALSNPISTEVLGLAGFDWLVLDGEHAPNDISTFIPQLMALKGSASAPVVRVPTNEPVIIKRLLDIGFYNFLIPFVETKEEAEQAVASTRYPPEGIRGVSVSHRANMFGTVADYFAQSNKNITILVQIESQQGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGNASHPDVQKAIQHIFNRASAHGKPSGILAPVEADARRYLEWGATFVAVGSDLGVFRSATQKLADTFKK
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
What are the official names of this protein?
5-keto-4-deoxy-D-glucarate aldolase, KDGluc aldolase, KDGlucA, 2-dehydro-3-deoxy-D-glucarate aldolase, 2-keto-3-deoxy-D-glucarate aldolase, 5-dehydro-4-deoxy-D-glucarate aldolase, Alpha-keto-beta-deoxy-D-glucarate aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Protein: TFOX_HAEIN
Sequence: MNIKDEHIDSVCSLLDQLVGNVSFKNLFTGYGLFHKEETMFAIWQNKKLYLRGEGVLAIQLTKLGCEPFTTNELNKRFVLSQYYALSDQILRSNRLCRKLIILSIKQILEQKLECTLRKLNRLKDLPNLTIKHERALIKVGITNVAMLREIGAENALVELKKSGSGATLDFYWKLVCALQNKNSQMLSQAEKERLLKKLNEVWRKNGLKGYRKLDDE
What is the function of this protein?
Required for DNA transformation (PubMed:1653215, PubMed:18761017).  Positively regulates genes required for DNA transformation (late competence-specific genes) in association with CRP (PubMed:18761017).  Required for expression of the dprABC operon (PubMed:9244270).
What are the official names of this protein?
DNA transformation protein TfoX, Competence activator Sxy, Protein Sxy.
What is the protein family that this protein belongs to?
Belongs to the TfoX family.