PharMolix/UniProtQA huggingface dataset:
Protein: KCNE1_PONAB
Sequence: MILSNTTAVTPFLTKLWQETVQQGGNVSGLARRSPRSDDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLKSYRACYVVENHLAVEQPNTHLPGTKPSP
What is the function of this protein?
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits.  Modulates the gating kinetics and enhances stability of the channel complex.  Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.  Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel.  The outward current reaches its steady state only after 50 seconds.  Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
What are the official names of this protein?
Potassium voltage-gated channel subfamily E member 1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel KCNE family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Membrane raft. Note=Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KCNQ1 (By similarity).
Protein: TM233_MOUSE
Sequence: MSQYASRSDSKGALDSSSPEAYTEDDKTEEDIPAPSNYLWLTIISCFCPAYPVNIVALVFSIMSLNSYNDGDYEGARRLGRNAKWVAIASIIIGLVIIGVSCAVHFSRNP
What are the official names of this protein?
Transmembrane protein 233, Dispanin subfamily B member 2, DSPB2.
What is the protein family that this protein belongs to?
Belongs to the CD225/Dispanin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ATAT2_DROME
Sequence: MVEFAFDIKHLFPQSIIRVQAHSLRPKVTQCRRYAQTERGKSTMTSCRLSEILNIMGKLSADAQGLCHAVTSADKLASDQVVYLMADKAAGHWEITGLLKVGTKDLFVFDQGGCYRRLNQTPAILDFYVHESRQRCGQGKLLFEWMLEKQGWSAHKCTVDRPSNKMLAFMAKHYGLVRTIPQGNNFVLYEGFFDDPITTCKSASGLQATGSGCRSRSQGHYVRQEQDQAQIKHGQANRNTVQNDANSGPFRQDQKIVVGTSIYRRRWKSPRTLARAGCREVSGGRRF
What is the function of this protein?
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules.  Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity.  Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer.  Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules.  Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released.
What are the official names of this protein?
Alpha-tubulin N-acetyltransferase 2, Alpha-TAT 2, TAT 2, Acetyltransferase mec-17 homolog 2.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase ATAT1 family.
Protein: PCSK5_BRACL
Sequence: MPPAIVILALFTAALCAVNLRTVAADGPRIYRNEWALHVEGGTAAADRLASKHGFINKGQIGSLEDHYLFVHRRTWKRSLRSSSHRHALLQREPEVRWLQQQVVKRRVKRRVKRVYSMYPWEQRVQHSSPQVNNPAQQDNLWDPHFNDEKWDKMWYLHCDRPEFACQWSDMNVEAAWKKGYTGKGVVVSILDDGSETDHPDLAGNYDPDASSDINGGTLDPTPRYEYTNENRHGTRCAGEVAAMGNNSFCSVGVAYKASIGGVRMLDGDVTDSVEAASLGLNPQHIMIYSASWGPDDDGKTVDGPANLAQKTFQAGAENGRDKLGSIFVWASGNGGRTHDSCGCDGYTNSIYTISVSSASEQGKVPWYLEPCASTLATTYSSGAPHERKVITTDLRKGCTESHTGTSASAPMAAGILALALEANPMLTWRDMQYIVVMAANPSPLDRDTESAYPRDPRKESDFVTNGAGLRVSHNFGFGLMDAGKMVELAESWRRVPEQHVCEEDPNAQQRAITKGETIVDTKTTGGCNGTDHHVKYLEHVVVEISLDHPCRGHLSIHITSPSGTRSTLLPERQFDSSSDGLKDWAFMTTHCWGEQPEGDWILEVKDLGQQNCQRYGLRTVLPVLRKWKLILYGTAEHPLYKRDEESRPHTPQTREEPTDEEECEDGDYYDRSKQRCRHCHDSCATCHGRHSGQCLSCHEGNYFVEDEGTCSEECGQGYYKDEEERKCLDCSADCLTCQVSADHCTSCDDEDGLKLFENTCVAQCSEGRYMDENDVCQDCDDSCDTCTGPDATDCVTCADEDLLQESQCVESCSSGYFQQEYECLKCHATCASCSGSRDDQCLTCSGHLELDEDTHRCITSCEDGEYGTEEGKCEDCNIICKKCNGSQADQCLECHHDTNLYDTTCVQYCGNRRYPENGECHPCHPSCLGCIGGEINQCNQCITDYEGEDHFLYQGTCHVTCPPGLYGDTTDQVCKACAPGCIACDGPADNQCTLCEEERAPTDGRCQSEGSQTDEAECAEGCHSCEEGPDICDSCDEDYYLTEDTCVRRTNCPSFTYPDDQDRECRPCHDNCEACDGPNNQNCNSCKEGFYKTPDGCSTGCPNRYYKDDTNKECKPCDSSCFTCSGPASFHCLSCADGDFLHESSCRSTCPAGFIGNAESHECVESSCEQDQYYSSETGRCEDCPYNCRACDNDGDCAECAPTYIVVDGRCRPEETCEDGEYQDRDRDTAELSCRPCHQSCKTCSGPSDTDCDSCKGDDTILDRGECITSCGPGEYMDRREKKCKACHPTCKECSDEYDDTCTACNDGFLLTDASSCEAGCPPGQFLHHGDCDSCHRECKTCDGPHHDNCLSCQPGSYLNDQQCSTHCPEGTFEETYEDDSGETVLQCRLCHVNCKTCHGEGEEDCMECANDIKYKQDGRCVTECQEGHYPDLTNECQQCWSDCETCDGPRNDQCVTCPYNYYLVLGKCLEDCPEGYYDTMRQEKECGECHPSCATCNEGGNYNCLSCPYGSKLGEGVCYPMCEEHEYYVEKTQICEECDNSCKTCRGSTAHDCLSCEAPYGYHAMKHLCTACCEEGSPENEYCCICHESTRLCITDREAEGVQFSSADSIPTNVAYIAVATFICVVIVVLFFVVFGMLQARSNGRLCWAHKYQQVPTTRYEKMNDHVNILSQEDFYNEDSLSEDEIHSIDSTRH
What is the function of this protein?
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif.  Likely functions in the constitutive and regulated secretory pathways.
What are the official names of this protein?
Proprotein convertase subtilisin/kexin type 5, Proprotein convertase PC6-like, aPC6.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
[Isoform A]: Secreted. SUBCELLULAR LOCATION: [Isoform C]: Secreted. SUBCELLULAR LOCATION: [Isoform B]: Cell membrane; Single-pass type I membrane protein.
Protein: CAPP_RHOP5
Sequence: MSSTVLSVEPDALPRSGEDAAAIAEDARLRDDIRLLGRILGDTVRDQEGEDVFDAVERIRQTSIRFHRDNDQPARDELVELFDGLSTPATLRIVRAFSYFSHLANLAEDQNNIRQMRLQNGARPGSLVATLAHARAVGISAKELRHFFETALVSPVLTAHPTEVRRKSTMDREMEIARLLDRRERLQMTPEEIEQHEELLRRAVLTLWQTNMLRRTKLTVLDEVANGLSFYDYAFLHEVPRLHGVLEDKLNDDDGAGEELASFLRMGSWIGGDRDGNPFVTAEVMRGTLRLQSRRALRHYLDELHALGSELSIAAHLADISDELRALAENSPDTSPHRAGEPYRLAVSAIYARLAATAHRLGIDDIRAPVAESAPYAEPAELKADLDVLHRSLVANNSAVIARGRLRSLRRAVDCFGFHLASLDMRQNSAVHERTMAELIDKAMPGKSYMAMNEEARIALLAAELRSPRPLASPFVKYSEETVDELAVFRAAAEAHATFGPAAIPQCIISMTKGVSDLLEVVVLLKEVGLVDPAGRSAINVVPLFETIEDLQAAAGIMDRLLGLHDYRRLVDSRGGVQEVMLGYSDSNKDGGFVTSGWELYKAEIELLKIFEHHGVRMRLFHGRGGSVGRGGGPSYDAILAQPAGAVNGQIRITEQGEIITSKYSNPEVGRNNLEVLAAATLEASLLQPRLGAPCVGYLKAMDEISALAFKAYRGLVYETEGFEDYFWSSTVITEIATLNIGSRPASRKKTHKIEDLRAIPWVFSWAQCRLMLPGWYGFGSAVEAWVKAHPEQGMAYLQELNREWPFFRTLLSNMDMVLSKSSIAIASRYAELVADEKLRAAIFGRIKREWHSSIAALLAIMGHQRLLQGNPRLERSIRHRFPYLDPLNHVQVELLKQHRDHAVDEQALRGIQITINGISAGLRNSG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: VE94_NPVAC
Sequence: MINYYVYATDDSLSTNSDYYFNKNALQTLEQFQNEIENISSCDKVLYLHWSAYCRQKEIGDVKSRYLRRNGEGTDTRPSEFIKWIHKNINLLDGKLKLLYMVTDGQISKNEANVCKNLLNEKPFSFERIVFYAINNNTEQIDLSVASAFVNNSDCKIYRNDEMVEWVNLTKEFNYDIITTENFISKKDELLSFVRFKFINSMPTDANVLNEVDKLKRLRQRLFSEIKQTNNSSMNFDQIKNKNEFVNTFKSTEFYKTLYNADVLNFDKIIDSTISTAINYLHNRNKSYAFDVMKNLHYQNKLASVNAETDDVVANDDDEAYDYSNVENIRFPDCILANDSGVPAILLTHYNLFETIQGSLTKFKSRLEFPLLWSQNKEIKNSIEYCYNLESLKQLIQHGTRLSPRSRRPFTGAIVPNEQFDEYNDYVLACTYFDAKKVAFNAGLMYYLLYKHINDAEYIDDNVKDYFKRYVIYRINNTECMIGFSNLAMEPLIKVKLPTALWYVSEISTLLFKHDNQHFGKEKLRQFAHFAEDMLQILQWCDYTDVNVEAVKKRAYCLKRINMFKRMSVLDAVEWIANRAFECKDKFIINKLTNADALQDLKFLKVNHNGVVDEHVLNDTSINAERYLYFYHIIEDFDKYISVVDNTMRPAFVLEEGKTFYDSLLKQLQSVHFNGQEITFEKCSRLDFNRILSLHKLYIECVKSLNKYPTLEEYQNYVYNQKHVKFNRIAIFPENILQNLAAVHNEYANKIVNLPVEEFIVRANNTVNRITRIQNERVGSPLQAEEIDKLIKLSEQRVNICRK
What are the official names of this protein?
Early 94 kDa protein.
Protein: GLUQ_SYMTH
Sequence: MLCGRFAPTPSGALHLGNARTALLAWLHARRAGGRFILRIEDIDRARSRPHLAEQAIADLRWLGLDWDEGPDVGGPHGPYCQSEREELYRDALARLQAEGRLYPCYCSRAQLMAIASAPHGLTSEGPAYPGTCRRLTPEERRAREADGKTPSLRFALPDEEIAFTDLIAGPQRFPPGAGGDFVVLRADGVIGYQLAVVVDDALMGVTHVLRGGDLLDSTPRQILLYRALGRPVPAFGHLPLLLGPDGARLAKRHGAVTLAGIRAAGTSPETVVGHLAYLSGLVDQPEPVRPEELIPVFDLARIPREPVRIPAETIAALSGGTA
What is the function of this protein?
Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp).  Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.
What are the official names of this protein?
Glutamyl-Q tRNA(Asp) synthetase, Glu-Q-RSs.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
Protein: RL20_RICRS
Sequence: MTRAKSGKISKNRHKKILKLAKGYRGRANSCFRVAIEKVEKALQYAYRDRRNRKRDFRGLWIQRINAAVREHGLVYSQFMGALKKTEIAIDRKVLAELAVNNSDGFVSIVEKAKAHI
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: VF145_ASFK5
Sequence: MDHYLKKLQDIYKKLEGHPFLFSPSKTNEKEFITLLNQALASTQLYRSIQQLFLTMYKLDPIGFVNYIKASKQEYLCLLINPKLVTKFLKITSFKIYINFRLKTFYISPNKYNNFYIAPSEEKANHLLKEEKTWAKIVEEGGEES
What are the official names of this protein?
Uncharacterized protein K145R, pK145R.
What is the protein family that this protein belongs to?
Belongs to the asfivirus K145R family.
What are the subcellular locations of this protein?
Virion.
Protein: ILVD_SALNS
Sequence: MPKYRSATTTHGRNMAGARALWRATGMTDSDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDKIIKLDLVDAMIQGADPKVSDDQSNQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVLGILGELDRAGLLNRNVKNVLGLTLPQTLEQYDITVTQDEAVKKMFRAGPAGIRTTQAFSQDCRWDSLDDDRAAGCIRSLEYAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDEAVEAILGGKVVEGDVVVIRYEGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGTIALIEDGDTIAIDIPNRSIQLQLSEAEIAARREAQEARGDKAWTPKNRQRQVSFALRAYASLATSADKGAVRDKSKLGG
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: BAG6_ARATH
Sequence: MMPVYMDPSQPCQMRPQEYYYQGFGNNSQHMAMDAPPPCHGSCVHGNFPAYWPPCYPPQVPYHQCCMNRSAFHPPHASYAPSCYVHPPFPVGYQPWFDVEKDVPGKHHCGKCSSQMCDLKKDRGVVIEEHEPEIEKGEAVLPVRSTNCPYPIIWIPHENARNQEYRSSLGLGKHNQPPAEVRAPDNMTIQKSFPESWRGCFPFDESSMKSLVQNQDSKKAQNGKTVEAPFDISKFKSLLQGQDMKEAQIQKNKEELGQLTYPTSWVPSRRKRDDVEASESSNEDRKKMQNGKTVEYPFDISMIKSLIQGQDVKEAQNQKNKEEPGQVPYPIFWIPSYGKRKDVEASESKESSNEGRNLESCPSDLHRNEGQITQAKGKEGNFECNVLSDAEEKSSVINIPVANHLQEPRNIPVKLSENHLPKPTEPTKRIAKNEPVKSTKKEQSSSSSEASKLPPVCLRVDPLPKERNGGSKSVSHPKRMEKSKETKIAAPLSSKKAESRTVPEACNVKCEDANAEMKMAEGSLNALRTEKGSVESNSNLQEESNGEIIKPCEAKENREQPAKKSFTEEEAARIIQSMYRGYDVRRWEPIKKLKEIATVREQMGDVKKRIEALEASTDQHIEEKEIVVNGELVMNLLLKLDAVEGLHPSIREFRKALATELSSIQDKLDSLKNSCASAEKEAVKEQVEIKSQPSDSPVNLEHSQLTEENKMVSDTNLEKVLRLSPEEHPMSVLNRTDEKQAESAAETEEGYGLFETLATDSKQATENAAAASSTTIPEKIGEVETVVPGNPPSADGNGMTVTNVEENKAMVVESLEEPINELPQMVEETETNSIRDPENASEVSEAETNSSENENRKGEDDIVLHSEKNVELSELPVGVIDEETQPLSQDPSSSYTREGNMTAMDPKTASQEETEVDHSPNNSKGIGQQTSEPQDEKEQSPETEVIVKEQPLETEVILNEQAPEPEITEPGISKETKKLMEENQRFKETMETLVKAGREQLEVISKLTSRVKSLEKKLSHKKKTQIRRRASKPMSVSPTDAVL
What is the function of this protein?
Induces autophagy.
What are the official names of this protein?
BAG family molecular chaperone regulator 6, Bcl-2-associated athanogene 6, CaM-binding protein 1.
Protein: RS9_SHESW
Sequence: MAATQYYGTGRRKTSTARVFAKAGSGNIVVNQRPLDQYFGRETARMVVRQPLELVEMTDKLDIYVTVKGGGITGQAGAIRHGITRALMQLDEALRPSLRSAGFVTRDARKVERKKVGLRKARRKPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: MRH4_COCIM
Sequence: MTSFSHLSRLRMSAFLPHVCLQCRLKTVSSLPAQSSASSLLQAVRHASSARPRRRTPSRMTLSPNVAQSTVKYGEKRKSVRHQNGPFGGMNQRRANLRDRQRPRSQAELKRTSFKKDKDGSEKKQPELFKALKMQTALSSVSYGRRTSIKSKISNITSFDQFDLLPSVRQSVYDSALPGLEYVTPTPIQRLAIPAILRQGSATPKPEEGQEDMPRFDQYLLAAETGSGKTLAYLLPVVDAIKRTEAKDKEEEERMAKEELEKEQEQAKEKNQNLFELESPGEEEEPINAPKSVVKPKAIILVPTSELVEQIGRIVKQLAHTVKYRSALLASNYTPRKIRKTLFNPNGLDILVTTPYLVASIAEANPYIFSRVTHLVVDEADSLFDKSFSPKTNTIIDRTAPTLKQLILCSATIPRSLDNRLRERFPQIRRLVTPNLHAIPRRVQLGVVDIDKEPYRGRRHLACADAIWSIGRSGNPYDADVGYQVTGQKEPKSIIVFVNERETAAEVAEFLVTKGINAVSLTRDTSEKRQAQILAEFTTEKNPPQPEDYKMLKGNRSDDDSVPFVNVRPGNERSNRLSNTKVLVVTDLGSRGIDTVAVKTVILYDVPHSTIDFIHRLGRLGRMGRRGRGIVLVGKKDRKDVVREVREAMYRGQALI
What is the function of this protein?
ATP-binding RNA helicase involved in mitochondrial RNA metabolism.  Required for maintenance of mitochondrial DNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase MRH4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. MRH4 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: LEUC1_SALCH
Sequence: MAKTLYEKLFDAHVVFEAPNETPLLYIDRHLVHEVTSPQAFDGLRAHHRPVRQPGKTFATMDHNVSTQTKDINASGEMARIQMQELIKNCNEFGVELYDLNHPYQGIVHVMGPEQGVTLPGMTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQGRAKTMKIEVTGNAAPGITAKDIVLAIIGKTGSAGGTGHVVEFCGDAIRALSMEGRMTLCNMAIEMGAKAGLVAPDETTFNYVKGRLHAPKGRDFDEAVEYWKTLKTDDGATFDTVVTLRAEEIAPQVTWGTNPGQVISVTDIIPDPASFSDPVERASAEKALAYMGLQPGVPLTDVAIDKVFIGSCTNSRIEDLRAAAEVAKGRKVAPGVQALVVPGSGPVKAQAEAEGLDKIFIEAGFEWRLPGCSMCLAMNNDRLNPGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVTGHFADIRSIK
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase large subunit 1, Alpha-IPM isomerase 1, IPMI 1, Isopropylmalate isomerase 1.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
Protein: MINY4_XENTR
Sequence: MEICYVQEVASSLVREFLSRKGLKKTSLTLEEELPRAPRSISTRNELRAALHLDRLYKENKLTEKPLKTLLEIMTKYFLEHSGKTKALNMRGEQNPAPPKGLATNLQQRHAGDLMMAVCDVSDDETGESSAVSDTSKTEIYRSQNDLQFNKSNHLKGPDRKQKQTEAGVTSTGVCSEGELMPPRVNIREHQERESWEMALGAKSSRSETQRPRSSRMVRGMMSGPTASSQEDSLKKRGPRRSAAANTPNPIKGEVLSEITGGMGEPSTIAPANTALKLGKEFAAKLLSTSENLRNVSLCSTNAVPKPNAFAAAETAADGKGATEASPYASNEHRRRSGFSNMDLNSASLAKKTLPFHRERNDKEDLKLDDVEDCLVTEEIRNIPTALPGNLKQIEGKPIDLAQAVEIKKILFGSSFCCFSDEWKIQSFTFNNNQPLRYGFIQKKGGPCGVLAAVQGCVLKNLLFGKDADLRVLQPSDSQRTSCLCKAIADILWRAGDNKEAVVALSCGRPQFSPAGRYKADGILESLILYKIRKYEDLMGFVQQHISQFELGPFGCTLLTLSVVLSRSVELVQKDFDVSTNCLIGAHSYCTQELVNLILSGRAVSNVFNDVVELDSGNGNITLLRGVAHRTDIGFLSLFEHYNVCQVGSYLKTPRFPIWVICSESHFSVLFCVRRELMSDWKMERRFDLYYYDGLANQQDEIRLTVDTAATYIEEQENDLTPPLEHCIRTKWKGAVIDWNGTEPIL
What is the function of this protein?
Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
What are the official names of this protein?
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4, Probable deubiquitinating enzyme MINDY-4.
What is the protein family that this protein belongs to?
Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
Protein: PG26_MYCTU
Sequence: MSNVMVVPGMLSAAAADVASIGAALSAANGAAAPTTAGVLAAGADEVSAAIASLFSGYARDYQALSAQMARFHQQFVQALTASVGSYAAAEAANASPLQALEQQVLAAINAPTQTLLGRPLIGNGADGLPGQNGGAGGLLWGNGGNGGAGDAAHPNGGNGGDAGMFGNGGAGGAGYSPAAGTGAAGGAGGAGGAGGWLSGNGGAGGNGGTGASGADGGGGLPPVPASPGGNGGGGDAGGAAGMFGTGGAGGTGGDGGAGGAGDSPNSGANGARGGDGGNGAAGGAGGRLFGNGGAGGNGGTAGQGGDGGTALGAGGIGGDGGTGGAGGTGGTAGIGGSSAGAGGAGGDGGAGGTGGGSSMIGGKGGTGGNGGVGGTGGASALTIGNGSSAGAGGAGGAGGTGGTGGYIESLDGKGQAGNGGNGGNGAAGGAGGGGTGAGGNGGAGGNGGDGGPSQGGGNPGFGGDGGTGGPGGVGVPDGIGGANGAQGKHG
What are the official names of this protein?
PE-PGRS family protein PE_PGRS26.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PE family. PGRS subfamily.
What are the subcellular locations of this protein?
Cell surface.
Protein: EXOC1_HUMAN
Sequence: MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVKVVKVKKSDKGDFYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLRKKIDFVNVSSQLLEESVPSGENQSVTGGDEEVVDEYQELNAREEQDIEIMMEGCEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNAADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNNLIALGDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNHFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH
What is the function of this protein?
(Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1).  This results in decreased viral RNA synthesis and decreased viral protein translation.
What are the official names of this protein?
Exocyst complex component 1, Exocyst complex component Sec3.
What is the protein family that this protein belongs to?
Belongs to the SEC3 family.
What are the subcellular locations of this protein?
Midbody, Midbody ring. Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Note=Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes in cell membrane in the presence of SLC6A9 (PubMed:16181645).
Protein: KDGD_POLNA
Sequence: MNPQDLKTIVSSGLLSFPVTDFDEQGDFRPKTYIERLEWLAPYGATALFAAGGTGEFFSLTGDEYPLIIKTAVNTCAGKVPIIAGVGGPTRFAIACAQEAERLGAHGILLLPHYLMEAGQEGLIAHVEAVCKSVKFGVIVYNRNVCKLTPESLAILADRCPNLIGFKDGVGNIETMSSIFMKMGDRFSYLGGLPTAEVYAAAYKALGTPVYSSAVFNFIPKTAMDFYHAVASDDLATQHRLLRDFFMPYLALRNKNPGYAVSIVKAGATIVGHDAGPVRPPLTDLKPAEMEELAVLIKSLGPQ
What are the official names of this protein?
Probable 5-dehydro-4-deoxyglucarate dehydratase, 5-keto-4-deoxy-glucarate dehydratase, KDGDH.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
Protein: SC6A8_HUMAN
Sequence: MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
What is the function of this protein?
Creatine:sodium symporter which mediates the uptake of creatine (PubMed:7953292, PubMed:7945388, PubMed:9882430, PubMed:17465020, PubMed:22644605, PubMed:25861866).  Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity).
What are the official names of this protein?
Sodium- and chloride-dependent creatine transporter 1, CT1, Creatine transporter 1, Solute carrier family 6 member 8.
What is the protein family that this protein belongs to?
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
Protein: TRPA_ACIET
Sequence: MSRIADTFAELQSKGRKALIPYVTAGFPFVDITPALMHGMVEAGADVIELGVPFSDPMADGPVIQKAGEKALALGVGLAQVLEMVRSFRLRNSTTPVVLMGYANPVERYEQRHGKGAFARDAGEAGVDGVLIVDYPPEECEQFAADLRGHGIDLIFLLAPTSTAERMQQVARVASGYVYYVSLKGVTGSGALDTAAVEAMLPRIREHVKIPVGVGFGIRDAATAQAIGRVADAVVIGSRIIQLIEDQPHEKVVGITVDFLRGVRKALDA
What is the function of this protein?
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
What are the official names of this protein?
Tryptophan synthase alpha chain.
What is the protein family that this protein belongs to?
Belongs to the TrpA family.
Protein: CD3E_FELCA
Sequence: MPSGSLWRVLGLCLLSVGAWGQEDNEDPLEPSPQTSASARYKVSISGTTVVLTCPEDLGSESIKWERNGDLLPNEYGEQLFLDDFSEMENSGYYACYTSNSLEKNYLYLKARVCQNCVEVDTMTAVAIVVADVCITLGFLLLVYYWSKNKKASSVTMMRGPGAGGRPRGQNKEKPPPVPNPDYEPIRKGQQDLYSGLNQRGI
What is the function of this protein?
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.  In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development.  Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E.  Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
What are the official names of this protein?
T-cell surface glycoprotein CD3 epsilon chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: M28P2_ARTOC
Sequence: MARPAAGPGGISKFGNDFGLQRWRNTPRYDQTQPLEGSVCGYGLSNPFHESLFSCPAASWPQAKLGRPNTPQEPSKDLKRILSQISPKRIEATIRKLVSFGTRHTLSTQTNATHGIGAARDWIASEFQRYADASDGRLTVKVIGYEQQPDGSRVLFPVRISDVVATLKGSEDPERVYVVSGHYDSRASDPLDYKTDAPGANDDASGVAVSLEIARVMSQRNLPRPKATIVFAAVAGEEQGLLGSNFLAQTYRNSSTNVEGMFTNDIIGSSTADDGTKEPHVIRLFAQGVPPLNVENQAMREKRLMIGGENDTPARQLARFVKETAENKYTDMQVSVIYRLDRYLRGGDHRPFLEAGYPAARFTEPNENYAHQHQNIRIEKDPKTGKDIQYGDLPEFCDFDFISRVGKVNAAALWNLAMSPGMPRNVRVDTSDLSNDSKFTWDPPAGGNAGVGGYEIVWRSTIAPFWTNVMDVGMVQAATIDLSKDNVIFGIRARGKNGERGVAVLPFP
What are the official names of this protein?
Probable zinc metalloprotease MCYG_04217.
What is the protein family that this protein belongs to?
Belongs to the peptidase M28 family. M28B subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SELU_BORBR
Sequence: MRADTRDFRALFLGDAPLLDTRAPVEFAKGAFPGAVNLPLMSDAERHKVGLCYKQQGQDAAIALGHRLVSGAVKAERVAAWAAFAQAHPEGYLYCFRGGLRSQISQAWLREEAGIAYPRVIGGYKAMRGFLLETIEQAIAECGFVVLGGMTGTGKTDVLRQLDHGLDLEAHAHHRGSSFGKHATGQPAQIDFDNRLAIDILKKRAAGCRQFVVEDESQAIGSCSLPFGLYQGMQRYPVVWLEDTQPARVQRILRDYVIDLCGEFTALHGEQDGFGLYAARLRQSLDNIARRLGGERHRRLAALMDEALARQAGDGSVDAHRAWIEPLLTEYYDPMYAYQRQAKAARIVFTGDHQEVLDYLRGPGRALP
What is the function of this protein?
Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA).  Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.
What are the official names of this protein?
tRNA 2-selenouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the SelU family.
Protein: MTND2_CAEEL
Sequence: MVQIWQMEPYPCGDPRLPHHLFPPKKITPDELSKRTGTLYWKLDTLDQVALAKRLTTLKLEHSFKKEDIFTLDAETTANFDDKIEELFEESSVPFEQARMIIEGTAYYDVEDKNGQWVRIFCEYGDLILIPANTCFRFTTTPHNFVKMRRFYKDEDSE
What is the function of this protein?
Probable inactive acireductone dioxygenase.
What are the official names of this protein?
Probable inactive acireductone dioxygenase 2.
What is the protein family that this protein belongs to?
Belongs to the acireductone dioxygenase (ARD) family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.