PharMolix/UniProtQA huggingface dataset:
Protein: THIE_LISMC
Sequence: MRAELAVYFIAGTQDIVRGTLPGVLEEALKAGITCFQYREKGAGSLQTASERKEMALECQQLCAKYQVPFIINDDVALALEIGADGIHVGQNDEEIRQVIASCAGKMKIGLSVHSVSEAEEAERLGAVDYIGVGPIFPTISKADAEPVSGTAILEEIRRAGIKLPIVGIGGINETNSAEVLTAGADGVSVISAITRSDDCYSVIKQLKNPGYPS
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: RL30_BURL3
Sequence: MSEKTVKVQLVKSLIGTRESHRATVRGLGLRRLNSVSELQDTPAVRGMINKVSYLVKVIA
What are the official names of this protein?
50S ribosomal protein L30.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL30 family.
Protein: GATA_METS3
Sequence: MNVIEKLNSIQNKEMTAKENVENFIKVIDEKNEELNIFLEVNKESALKQAEAIDEKIANGEKVGFLSGLVFGIKANINVEDYIISAASKTLDNYFGSYNATVIDKILAQDGIILGITNMDEFAAGSSTETSCFGPTQNPAAPGRIPGGSSGGSAAAVAAEMCDIALGSDTGGSIRNPASHCGVVGFKPTYGAVSRQGLLDLSMSLDQIGPLSNDTSGIALALNAISDYDETECTTLHGKRPDFTSALEEKSLEGMKIAVCKEFIDVTDAEINVAVNKAIHKLVEAGAELVEVSFDNIDLCLPTYYLINYVEFFSATRKYDGRDYGYRIEDVCGEEVLRRIEIGSYISQKEYSGKFYKKALQARSLIRDEINAMLENVDLIVGPTVPKLPHKIGDELTPMEMYAYDVLTVIANLAGIPAGSIKAGEVDGIPVGLQIQAKPLDDLKIIKAMSVFENEN
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: DLDH2_PSEAE
Sequence: MSQKFDVVVIGAGPGGYVAAIRAAQLGLKTACIEKYIGKEGKVALGGTCLNVGCIPSKALLDSSYKYHEAKEAFKVHGIEAKGVTIDVPAMVARKANIVKNLTGGIATLFKANGVTSFEGHGKLLANKQVEVTGLDGKTQVLEAENVIIASGSRPVEIPPAPLTDDIIVDSTGALEFQAVPKKLGVIGAGVIGLELGSVWARLGAEVTVLEALDKFLPAADEQIAKEALKVLTKQGLNIRLGARVTASEVKKKQVTVTFTDANGEQKETFDKLIVAVGRRPVTTDLLAADSGVTLDERGFIYVDDHCKTSVPGVFAIGDVVRGAMLAHKASEEGVMVAERIAGHKAQMNYDLIPSVIYTHPEIAWVGKTEQTLKAEGVEVNVGTFPFAASGRAMAANDTTGLVKVIADAKTDRVLGVHVIGPSAAELVQQGAIGMEFGTSAEDLGMMVFSHPTLSEALHEAALAVNGHAIHIANRKKR
What is the function of this protein?
Also acts in the glycine cleavage system.
What are the official names of this protein?
Dihydrolipoyl dehydrogenase, Dihydrolipoamide dehydrogenase, E3 component of 2-oxoglutarate dehydrogenase complex, Glycine oxidation system L-factor, LPD-GLC.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS11_RHOJR
Sequence: MPPKSRGTGPKKTQKARRRDKKNVPHGAAHIKSTFNNTIVSITDPAGNVISWASSGHVGFKGSRKSTPFAAQLAAENAARKAQEHGVKKVDVFVKGPGSGRETAIRSLQAAGLEVGTISDVTPQPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: MDFIC_MOUSE
Sequence: MSCAGEALAPGPAEQQCPVEAGGGRLGSPAHEACNEDNTEKDKRPATSGHTRCGLMRDQSIWPNPSAGELVRTQPERLPQLQTSAQEPGKEETGKIKNGGHTRMSNGNGIPHGAKHVSVENHKISAPVSQKMHRKIQSSLSVNNDISKKSKVNAVFSPKAASSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCSCPCDMDCGIMDACCESSDCLEICMECCGICFPS
What is the function of this protein?
Required to control the activity of various transcription factors through their sequestration in the cytoplasm.  Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation.  Modulates the expression from cellular promoters.  Binds to the axin complex, resulting in an increase in the level of free beta-catenin.  Affects axin-regulation of the WNT and JNK signaling pathways.  Involved in the development of lymphatic vessel valves (PubMed:35235341).  It is required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (By similarity).
What are the official names of this protein?
MyoD family inhibitor domain-containing protein, I-mfa domain-containing protein, Kidney cell line-derived transcript 1.
What is the protein family that this protein belongs to?
Belongs to the MDFI family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Nucleus, nucleolus.
Protein: BH106_ARATH
Sequence: MQPETSDQMLYSFLAGNEVGGGGYCVSGDYMTTMQSLCGSSSSTSSYYPLAISGIGETMAQDRALAALRNHKEAERRRRERINSHLNKLRNVLSCNSKTDKATLLAKVVQRVRELKQQTLETSDSDQTLLPSETDEISVLHFGDYSNDGHIIFKASLCCEDRSDLLPDLMEILKSLNMKTLRAEMVTIGGRTRSVLVVAADKEMHGVESVHFLQNALKSLLERSSKSLMERSSGGGGGERSKRRRALDHIIMV
What are the official names of this protein?
Transcription factor bHLH106, Basic helix-loop-helix protein 106, AtbHLH106, bHLH 106, Transcription factor EN 56, bHLH transcription factor bHLH106.
What are the subcellular locations of this protein?
Nucleus.
Protein: BETA_VIBVY
Sequence: MQQHYDYIIVGAGSAGCVLADRLSESGDHSVLLLEAGGSDKSIFIQMPTALSYPMNSEKYAWQFETDAEADLDGRRLHCPRGKVLGGSSSINGMVYVRGHACDFDEWEEQGAKGWNYQACLPYFRRAENWIDGEDEYRGGDGPLSTCAGNKMTLNPLYRAFIDAGKEAGYPETSDYNGYQQEGFGPMHMTVKNGVRASTSNAYLSRAKKRSNFKLIKGVVVQRILLEEKRAVGVEFELAGELRTCFAKNEVISSAGSIGSVQLLQLSGIGPKTVLEKAGVTPVYHLPGVGQNLQDHLEVYFQYHCQKPITLNGKLDWFSKGLIGTEWILTRKGLGATNHFESCAFIRSRAGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVGPNKPESRGRVEIVSANPLDKPKIQFNYLSTERDRQDWRDCIRLTREILAQPAMDEFRGEEIQPGINVATDAEIDQWVKENVESAYHPSCSCKMGADDDPMAVLDEECRVRGITNLRVVDSSVFPTIPNGNLNAPTIMVAERAADLILHKQPLPPQRSKVWLAPSWETQQRTGEPMR
What is the function of this protein?
Involved in the biosynthesis of the osmoprotectant glycine betaine.  Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
What are the official names of this protein?
Oxygen-dependent choline dehydrogenase, CDH, CHD, Betaine aldehyde dehydrogenase, BADH.
What is the protein family that this protein belongs to?
Belongs to the GMC oxidoreductase family.
Protein: TRHO_BRUC2
Sequence: MSNLPFTVAALYCFAPLPQYESLREPLAQLCCANGIKGTLLLAAEGINGTVAGSAGAIEKLIAHITAIPGLGEPELKYSHASEMPFHRMKVRLKREIVTMGVEGIDPLKSVGTYIAPKDWNALIADENTVVVDTRNDYEYAIGTFEGAIDPQTRTFREFPEWVKQNRDRLEGKKIAMFCTGGIRCEKATAFVKGLGFDDVYHLKGGILKYLEEVPREQSVWNGECFVFDERVAVGHGLAESDVELCRACRRPLTPQDKLSQFFEEGVSCAGCYAERTPEDRARYAERQKQVKLAEKRGANKHIGS
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: DEFB_DRONO
Sequence: LPRHTLHCVAYHGYCFHSKV
What is the function of this protein?
Has bactericidal activity.
What are the official names of this protein?
Beta-defensin.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LKA2B_MANHA
Sequence: MGNKFTNISTNLRNSWLTAKSGLNNAGQSLAKAGQSLKTGAKKIILYIPKDYQYDTDKGNGLQDLVKAAEELGIEVQKEESNDIAKAQTSLGTIHNVLGLTERGIVLSAPQLDKLLQKTKVGQAIGSTENITKGFSNAKTVLSGIQSILGSVLAGMDLDEALQNNSNELTLAKAGLELTNSLIENIANSVKTLDAFGDQINQLGSKLQNVKGLSSLGEKLKGLSGFDKTSLGLDIVSGLLSGATAALVLADKNASTSRKVGAGFELANQVVGNITKAVSSYILAQRVAAGLSSTGPVAALIASTVSLAISPLSFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSAAAAGSVVASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKNNPGKNYFENGYDARYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHLKADKLVQLDSANGIIDVSNSGKAKTQHILFRTPLLTPGTEKRERVQTGKYEYITKLNINRVDSWKITDGEASSTFDLTNVVQRIGIELDNAGNVTKTKETKIIAKLGEGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETEQGSYTVNRFVETGKALHEVTSTHTALVGSREEKIEYRHSNNRQHAGYYTKDTLTSIEEIIGTSHNDIFKGSQFNDAFNGGDGVDTIDGNGGNDRLFGGKGDDIIDGGDGDDFIDGGKGNDLLHGGRGDDIFVHRQGDGNDSITEAGGHDRLSFSDSNLKDLTFEKVNHHLVITNTKQEKVTIQNWFREEEFAKTVKNYVATRDEKIEEIIGQNGERITSKQVDELIAKGKDNKIDKNDLANVVNSYELLKNSRNVTNSLDKLISSVSSFTSSNDSRNVLATPTSMLDTSLSSLQFARAA
What is the function of this protein?
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture.  The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca(2+) and lysis of the host cell (By similarity).  This leukotoxin is a major contributor to the pathogenesis of lung injury in bovine pneumonic pasteurellosis.  It has also weak hemolytic activity.
What are the official names of this protein?
Leukotoxin, Lkt.
What is the protein family that this protein belongs to?
Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.
What are the subcellular locations of this protein?
Secreted. Host cell membrane; Multi-pass membrane protein.
Protein: NOP10_METMP
Sequence: MKMKKCPKCGKYTLKDFCSECNEKSVTVKPPRFSPVDKYGKYRRALKKAKM
What is the function of this protein?
Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
What are the official names of this protein?
Ribosome biogenesis protein Nop10.
What is the protein family that this protein belongs to?
Belongs to the NOP10 family.
Protein: RDRP_OUMVV
Sequence: MEPRQELLDPERVREEAKRIVRWLCGLVDRTGKLPAGDYQGKILNTVSEICKRSKLPCGELAEALTKGRLTRSLVDYSELLISNLVVGYFDVLEIYLGKQSVRLSDIREMACKYTFYAINRRLEDYIKFQTAWLQARAMRDVTPEPEAPSWLNEGFGRCFSALLNRKVHLRCVLRARPNDVSLAASLYQVKRVAPPLPDDQIEKNLEKSLDRLTKDEEPAGVDEPFLEDLKRECKRTVDELVQNARREGWNRKISRDCFPSQSAAFENPISKGGQLGQLVKENNTPRLPVLLGMFEYKGRVTPVYGWADDGDTILSDEELGREVPAALKCRRSPVLEPFKVRVITMGPAVQYYRARRVQGCLWDLLKHTRCTHLPNRPVEESDIGFYVRRRGADLFRGEEVPYVSGDYSAATDNLHPDLSLSVVDRVCDHLLSDDNRPLDPVSPWRVLFHRVLVGHRIYDGNSSRNTEVAAQSWGQLMGSPLSFPVLCIVNLAVTRYVLEKACGRIVTLEESGILVNGDDILFRCPERTIPFWTRMVTIAGLSPSPGKNFVSYRYCQLNSELYDMSGSRAEYLPFIKANLIYGTLARGCERKRAADLCYGDTTTEGGTFGHRARALIKGFGPDMQDRLMSRFLHSIKGFLEKIPEVSWFIHPRYGGLGLPLTRPVTHNPYHLRIAAYLSCGGEQSQEARCMMQWLSAPTKSFNAATLLRILEVARNCKVPFRKVPFALLHRAEAAGVDLEALFRKALLRSAPRLGVEYPSNESGDMQRLGDWRRFFRDVGRKAARTRCRSGTADERKGLFLMSPDNAVKGPQYEYIFDWASHNMGGNIWDPSYKFRADPFSSSESDEPRAKEIGPNRGPE
What is the function of this protein?
RNA-dependent RNA polymerase which replicates the viral genome.
What are the official names of this protein?
RNA-dependent RNA polymerase.
What is the protein family that this protein belongs to?
Belongs to the ssRNA positive-strand viruses RNA-directed RNA polymerase family.
Protein: TAM_AZOSB
Sequence: MPTWDDQQYLKFADERTRAARDLLARVPLDDAATVVDLGCGPGNSTALLVERWPQARVVGVDSSAEMLRSARQALPQVEWMQADLRAWAPAAPVDLIFANAVMQWLPDHATLLPELLRHLRPGGVLAIQMPRNYDEPSHRLMRETPGPWAARLAGARAIAPLPAAAWYYDLLAPHARQLELWQTTYEQVMDDAGAIVEWVRGTGLRPYLEALAEDEHPAYLAAYEAGIDAAYPPRSDGRRLFPFPRLFMVAVR
What is the function of this protein?
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
What are the official names of this protein?
Trans-aconitate 2-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. Tam family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL2_LINPO
Sequence: MGAFLTFQKDSDQIYPGWKEKLGYTGESSVQAASFDWQKKAAAAAFVGAQARTGRSTVVRRALDQSSRYADLSLTEEDLVKNGKHVLVAYIMNQGGYDYLATAAHVAAESSTGTNVNVCTTDDFTKTVDALVYYIDPENEEMKIAYPVPLFDRNITDGRAMMCSVLTLSIGNNQGMGDVEYGKIYDIYFPPSYLRFFDGPACSILDMWRILGRDMTDGGLVVGTIIKPKLGLQPKPFGEACYAFGQGGDFIKNDEPQGNQVFCQMNECIPEVVTAMKACIKETGSEKLFSANITADDPAEMIARGKYILGQFGPMAENCAFLVDGYVAGGTAVTVARRNFPKQFFHYHRAGHGAVTSPQTQRGYTAFVHTKISRVIGASGIHVGTMSFGKMVGDASDKGIAYMLQQDAAGGPYYHQKWEGVVQTTPIISGGMNALRLPAFFENLGHSNVILTAGGGTFGHKDGPKQGATSCRQDEEAWKLWKAGTYGDVSLSDGVIEYAKTHEEIKGAFLTFQKDSDQIYPGWKEKLGYTGESSVQAASFDWQKKAA
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site (By similarity).
What are the official names of this protein?
Ribulose 1,5-bisphosphate carboxylase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type II subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast. Note=In this organism the plastid is the result of a secondary endosymbiosis event, and thus is found within the endomembrane system, necessitating a complex targeting process.
Protein: PUR2_NOSS1
Sequence: MKVLVVGNGGREHALAWKLLQSPQIEQVACVPGNGGTATLARCQNVSLAVDDFEGISQYALNQGFSLVVVGPEVPLAKGITDYLQEKGLMVFGPSRAGAQIEASKAWAKALMQEAGIPTAKAAVFTEAAAAKSYIQAQGAPIVVKADGLAAGKGVTVATTIEQAQSAIDAIFQGQFGSAGEFVVIEECLTGQEVSVLALTDGLTIRPLLPAQDHKRIGEGDTGENTGGMGAYAPAPIATPELMALVQTEVLERAIATLQSKGIDYRGVLYAGLMITPNGDFKVLEFNCRFGDPETQVILPLLATPLEELILACVQQRLGELPPIAWQGGASATVVAASGGYPGDYEKGQVITGIPQAEATGATVFHAGTKLNAQQQIVTDGGRVLNVTGIGENFQQALAQAYTGIKAIDFSGIYYRRDIGYRVNS
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: CDD_PHOPR
Sequence: MHAKIMDALGSLPSDLASAVKPIFEDANFDATLSPEQFTTLLSTTHMTDSELRVALLPIAAAYSVAPISKFFVGAIVRGESGRLYFGANMEFVGASLSQTIHAEQSAISHAWIKGETGITDITINYSPCGHCRQFMNELTTAKTLIVQLPEREEQTLQQYLPESFGPADLNITDALLGKIDHGMTIKETDEFVAIACKAANGSHAPYTKNYSGVALKATDGKVFTGKYAENAAFNPSLPPLQVALVNMNMAGYALTEIAEAALVEKADSTISHLSDTQTTLEALNPDIPLTYVAA
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: CH10_THEYD
Sequence: MKIKPLKDRVVVKFSSEELEKTPGGIYVPDVAKEKPQKGTVVEIGSEVKEVKVGDTVLFDKYAGSKIKVDDVEYLIIKEEEILGIVEK
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PEBB_PROMM
Sequence: MKPSRLSSLDPVKMPEWRWAPFLSHAINAFIPLKPEPYPVAPEFLQREGKTGSKSQPIRVTTCTWACRTKKFRQVRAACVEAGRSASVLNFVINPYHTFDLPFFGADLVTLPSGHLLALDLQPAITSDERHTKQVWERLMPIFEHWRVHLPEGGPIPEEAKPYFSPGFLWTRLPLSIEGNQLIDEVIMPAFKDYLNLYLDLVEMAEEVSPQRAFKLLEGQKRYLSYRAKKDPARAMLARFHGHQWTESYIHNVLFDL
What is the function of this protein?
Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin.
What are the official names of this protein?
Phycoerythrobilin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: NEK6_PIG
Sequence: MAGQPSHMPHGGSPNNLCHTPGPAHPPDPQRHPNALSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGIVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCIYPDPNQRPDIGYVHQVARQMHVWTSST
What is the function of this protein?
Protein kinase which plays an important role in mitotic cell cycle progression.  Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis.  Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3.  Phosphorylates KIF11 to promote mitotic spindle formation.  Involved in G2/M phase cell cycle arrest induced by DNA damage.  Inhibition of activity results in apoptosis.  May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By similarity).  Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase Nek6, Never in mitosis A-related kinase 6, NimA-related protein kinase 6.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with APBB1 at the nuclear speckles. Colocalizes with PIN1 in the nucleus. Colocalizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis (By similarity).
Protein: CHEB_CALS4
Sequence: MKKKIRVLVVDDSAFMRRCLKDILENEEDMEVIDTARDGNEAVKKAVELRPDVITLDINMPVMDGLTALQYIMSLAPCPVVIISSLSTEGALTTFEALELGAVDFVAKPGGTVSLGIKQLADEIVSKVRIAALSNKELLSSSRNFKKLLKRRNQEVTRKVYENKISKKEIVVVIGVSTGGPKTLMEILPYLPSDFPAAVLVVQHMPPGFTQSFAQRLDQSCNLKVKEAEDKAFIEPGTVIIAKGGWHLVVERDSRSSKLITRLTQKPEETLYKPSINVTMKSVLENVDGRNIIGILLTGMGDDGADMMVEIRKRGGLTIAESQETAIVYGMPRAAVERGGAEIVAPAYKISDILLKKVNEYARTSEY
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPD_METPP
Sequence: MITDTAALQRTIEHREIFHDEMLHLMRRIMSGEMSPVMIAALAVGLRVKKESIGEIAAAATVMREFATPVPVADTEHLVDLCGTGGDAAHTFNISTTAMFVAAAAGARVAKHGGRSVSSTSGSADVLEALGASIDLAPAQVAECLAESGIGFMFAPNHHPAMKHAGPVRKELGVRTIFNILGPLTNPAGAPNQLMGVFHPDLVGIQVRVLQRLGSRHVLVVYGMNGMDEISLSGETLIGELKDGEVREYTVHPSDFGLPVYDTRGLKVASKDESVGCIRRALADEAGPVRDIVLLNAGAALYAADVAPSIGEGVRQAREAVASGAAAKTLERFVATTRRLKGAA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: G6PI_MARMS
Sequence: MSSPTKLTAWQKLTEHKQEMASVSMKSLFEADPKRAEKYTTQAAGWTLDYAKNRANEKTLSLLTDLAKEAGLESAIKGMFSGAHINNTEDRSVLHIALRASQAQETLMVDGVNVLAEVRATLKQMEAFVTQLHNGEWKGYTGKRITDVISIGIGGSYLGPKVVAEALTPYKKDGIKVHFVANIDGSDITGKLKLVNPETTVFVISSKTFGTLETLSNANAARDWFLSNGGSQSDVSKHFAAVSSNVKKAVDFGMAEENIFPMWDWVGGRYSLWSAIGLPVAIAVGMDNFYELLDGAHQMDEHFRTTPFEENLPVIMGTLGVWYINFHNAQTHALIPYDHYLRAMPAHIQQLDMESNGKSTLLNGDGVETDTGPIIWGGAGTNGQHAYHQLLHQGTRLVPVDFIVPLASHNPIGEHHAQLFANCLSQSQALMVGKTLEQAQQELRDAGASPDQVEAIAPHKVIKGNRPSNTLLTDKMTPATVGALIALYEHRTFVQGTIWGINSFDQWGVELGKVLGTDIYNRLVSDSDNSALDASTQALIKAFKKAQA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRK_STRPN
Sequence: MKVVAQEEIAPAIFELVLEGEMVEAMRAGQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIDGAGTAIFSTLSQGDTLDVMGPQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILKTELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHPRAYLSLESRMACGMGACYACVLKVPENETVSQRVCEDGPVFRTGTVVL
What is the function of this protein?
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit, Dihydroorotate oxidase B, electron transfer subunit.
What is the protein family that this protein belongs to?
Belongs to the PyrK family.
Protein: NS1_I72A2
Sequence: MDSNTVSSFQVDCFLWHVRKQVVDQELGDAPFLDRLRRDQKSLRGRGSTLGLNIEAATHVGKQIVEKILKEESDEALKMTMASTPASRYITDMTIEELSRDWFMLMPKQKVEGPLCIRIDQAIMDKNIMLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSFPGHTIEDVKNAIGVLIGGLEWNDNTVRVSKTLQRFAWGSSNENGRPPLTPKQKRKMARTARSKVRRDKMAD
What is the function of this protein?
Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated RIGI ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7.  Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR.  This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm.  Also binds poly(A) and U6 snRNA.
What are the official names of this protein?
Non-structural protein 1, NS1, NS1A.
What is the protein family that this protein belongs to?
Belongs to the influenza A viruses NS1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm. Note=In uninfected, transfected cells, NS1 is localized in the nucleus. Only in virus infected cells, the nuclear export signal is unveiled, presumably by a viral protein, and a fraction of NS1 is exported in the cytoplasm.
Protein: RHEB1_CAEBR
Sequence: MSSTATQPRYSLNRKVAVMGYPHVGKSSIVQRFTQNMFPDRYETTIEDQHTKHHTAFHRDFNLRVTDTAGQQEYTVFPRSCSLDVAGFLLVYAIDDRKSFDICSSIYEKIISVYGDPSIPIIIVGNKCDLGTQRVVQQEEGKELAKQCEAKFVEITARETNRVNEVFELLLREIEISRGNLRGPPQQQTKEQTSSDPNDPKNCVIS
What is the function of this protein?
Binds GTP and exhibits intrinsic GTPase activity.
What are the official names of this protein?
GTP-binding protein Rheb homolog 1, Ras homolog enriched in brain protein 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rheb family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: ASPR_HEDJA
Sequence: VTVVQYRSTNASSGYLNLRVYLLDTGLR
What is the function of this protein?
Alkaline thrombin-like serine protease.  Has fibrinolytic and fibrinogenolytic but not plasminogenolytic activity.  Cleaves fibrinogen chains Aalpha, Bbeta and gamma chains in that order.  Cleaves after Arg and Lys residues.
What are the official names of this protein?
Alkaline serine protease NJP.
Protein: RS6_SALPA
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYSAAITGAEGKIHRLEDWGRRQLAYPINKLHKAHYVLMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEASPMVKAKDERRERRDDFANETADDAEAGDSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: RS16_BURM7
Sequence: MVIIRLARGGSKKRPFYNIVATDSRNRRDGRFIERVGFYNPVATKGEALRIAQDRLTYWQGVGAQLSPTVERLVKQAQKAQPAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.