PharMolix/UniProtQA huggingface dataset:
Protein: DBP3_ASPCL
Sequence: MGKRVSHNEGADRRPKKKAKNEKPEKETMESPAADVTVDFGSKSDATYVQSQVLSDMPQSEIDQFLATHSIKVTDTSDAPAVRPIISFSHLPSCDSKLYSSLSSFASPTPIQSATWPLLFAGRDVIGIAETGSGKTLAFGLPCLKKILDSGKIKFKNARPAAVIISPTRELAMQIYDQISKYAGSIGIKATCIFGGVKKDEQREALKSAAIVVATPGRLKDLQNDGSVDLGKVKYLVLDEADRMLDKGFEQDIKDIISSTPDSKRQTVMFTATWPPSVRDLAATFMTSAVTVTIGGDPSADPRANTRIKQTVEVVQSHDKEYRLVQLLSENQRGAAALDKVLVFCLYKKEAMRVERLLRNKNFKVAGIHGDLNQHERFKSLDAFKSGAATVLVATDVAARGLDIPSVKLVINVTFPLTVEDYVHRIGRTGRAGAEGRAITLFTETDKAQSGALINVLKAAKQEVPQELLKFGTTVKKKQHGAYGAFFKEADSGKSATKIVFDD
What is the function of this protein?
ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis.  Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5. 8S rRNAs (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase dbp3.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RPOB_GLUOX
Sequence: MNAITKSFTGRKRIRKSFGRIPEIAPMPNLIDVQRASYEAFLQMNVSPDSRQDAGLQEVFRSVFPINDFAGRGRLDFMSYEFEDPKYDVEECIQRGLTYAAPLKVILRLTTWDIDEDTGSRSIHDMKEQPVYMGDMPLMTDNGTFIINGTERVIVSQMHRSPGVFFDHDKGKTHSSGKYLFAARVIPYRGSWLDFEFDAKDLIYVRIDRKRKLPVTTLLYALEGANYLAQREQKIAEGGDVEGLDIRGMDQDEILSYFYEAVPFTRLGGEWARPFDPDAFRGLKLLSPLVDADTGEVVAEADAKLTARMVRKIAEKTRVVQVGRLDILGRFLAYDLVNENTGEIYGEAGEELTEDRLAALEEMGITELPLLSVDGSHGPWIRNTLAADKNSCRDEALIDIYRIMRPGEPPTKETAEAMFHGLFFDQGRYDLSAVGRVKMNMRLDVDAPDTLRVLRKEDILRTIKIMCELKDGRGQIDDIDNLGNRRVRSVGELMENQYRVGLLRMERAIRERMGSVDIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETAGRPNIGLINSLSTYAKVNKYGFIETPYRLVEEGVLQDGWKYLSAMEEEKLVVAQADAKQDDQGRLTDELVSVRRSGDFRVVPPDQVTACDVSPKQLVSVAAALIPFLENDDANRALMGANMQRQAVPLVKADAPLVGTGMEAAVAHDSGATIVAKRRGVIDQIDGARIVVRATDEAGATQGVDIYRLRKYMRSNQSTCINQRPLVKVGDTVHAGDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILISERIARDDVFTSIHIEEFEVMARDTKLGQEEITRDIPNVGEEALRNLDEAGIVYVGAEVNPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLKLPPGTTGTIVDVRVFSRRGVDKDERAMAIERAEIERLTKDRDDERGIQERSFYNRLRERLIGQTAGAGFKGIRSGTPITEEVLDEHHRATWASITVTSDEVMAELEKLRGEFKEATRRIDARFDSKVEKLQRGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRVVPVEDMPFLENGQAVDIVLNPLGVPSRMNIGQILETHLGWACANIGASIGDMVDEYQRTGERKQELLDRLHEVYGDVIFNEDVATLPNEQLIELANNLRKGLPIATPVFDGASIPDIEEMLEKAGVNKSGQSQLIDGRTGEPFERQTTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEAIVREQDDFEAGIPESFNVLIKELKSLGLNVELEQSGL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: FGM1_GIBZE
Sequence: MPLILSITSSGTVLVLLTLLSLAAVVILSTYRLIKYRHIPGPLLCRVSHHYVTLFDLLRQRPQTVAKWHRQYGPFVQIAPGQVSISDVTAMRELYSSSARNPKSGYFDNFLYHNARAIFAEKEYLGHREKRGLVSSFFQATSVYKPDIQQPLRDRVLAAMMRIEENIITSGQGVVDVMPIINHYAWDNTTSLVFGPCHSSQALQGDENDRNLLARLKNSEMWGAVKNNLPIVFSGIKLAVAVYTRSTKYFSAEDDLDKWAMQRLYKTTSDPKSSQDERSIVQLIQHLRQNGRPLSDSYLESEIIDNLYAGQATVTVALTYAVYHLSRNPYWQSMVQRELDGLPRDADGLPNWTLLNKAPILEACIRESYRLNPVASGRAERVLARDSRYGDIFIPQNTIVSASTIALHLDPQVWLNPREFNPRRWLDATPDEILRLERSFIPFGYGARLCLGKAFANLQIKMFVAAIYSKDNTGLEIPGQTMEQWGTQDALPKGLKCRLRFEERK
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501).  The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892).  During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892).  The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892).  Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892).  The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase FGM1, C64 cluster protein NRPS5, Fg3_54 cluster protein FGM1, Fusaoctaxin A biosynthesis cluster protein FGM1.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: ATPE_STAS1
Sequence: MNTLSLNIVTPNGSVYDREDVNLAVLQTTAGEIGVMYGHIPTVAALEIGYVKINFDGGSEYIAVSEGFVEVRQDKLSIIVQTAEPANEIDVARAELAKSRAESHLNNEEDNSDVNRAKRALERANNRIRVANLQ
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PR7B1_MOUSE
Sequence: MNTSLTQLCFWALQILLMSNLLLWEDVVSVPTIGSGSGVSEMLTEDLFDDAIILSQHINSLAIETRRIFLSNNFSSDMFITFTLQFNRHDEFVVNGLNSCHTLPLKSPKTEKEAKRISLPDFMNMILSILRAWDNPLHHMETELKSMPGAPFAILARVKDIEVKNKILLDRIMKIAKKVKYGFEENEVYPAWSELASLQSANEESRFFALYKLSYCLFVDTDKVEHYLKHLKCRYFDGYMCQDSVNQINLL
What are the official names of this protein?
Prolactin-7B1, Placental prolactin-like protein N, PLP-N, PRL-like protein N.
What is the protein family that this protein belongs to?
Belongs to the somatotropin/prolactin family.
What are the subcellular locations of this protein?
Secreted.
Protein: Y4WJ_SINFN
Sequence: MPRADVERFVNDLDKGRLPANLKPSATGLAPIVAAGKSLGYNITLDEVQNYIRLDSRRKSTGKKLEAMANSKRGSRVPALPRLVQSSALDSPVTDGLTRPLHIAEKGAAVAAVVQLVVIVVHVSS
What are the official names of this protein?
Uncharacterized protein y4wJ.
Protein: KUNI_ORNMO
Sequence: LNVLCNNPHTADCNNDAQVDRYFREGTTCLMSPACTSEGYASQHECQQACFVGGEDHSSEMHSSCLGDPPTSCAEGTDITYYDSDSKTCKVLAASCPSGENTFESEVECQVACGAPIEG
What is the function of this protein?
Tick salivary thrombin inhibitor that plays an important part in the anti-hemostatic strategy of ticks (Probable).  Is a potent and highly selective thrombin inhibitor (Ki=10 pM) (PubMed:8947023).
What are the official names of this protein?
Ornithodorin, Thrombin inhibitor.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Secreted.
Protein: LSPA_AQUAE
Sequence: MENFLRKTAWLYLSIAVSVFLLDIITKNLAEKLFTTHVEVFPFLEFYLIYNKGVAFGLLSELPDPLRLPLLLITPVIALIITFLYALYSGDRIVAISMGLIGGGALGNLYDRLFLGMVRDFIHLHIGEYYWPAFNIADASISIGIALLILKYFFTKPALKNLVNRTR
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRM61_MOUSE
Sequence: MSFVAYEELIKEGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVICSRGGWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQDVCCSGFGVVHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAAHGFTELSTLEVLPQVYNVRTVSLPLPDLGANNLETNMGSDASPFRSGTPMKETVGHTGYLTFATKTPG
What is the function of this protein?
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.  Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries.
What are the official names of this protein?
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A, tRNA(m1A58)-methyltransferase subunit TRMT61A, tRNA(m1A58)MTase subunit TRMT61A.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y4554_STRMK
Sequence: MHAYVYKSQLKPDTYVYVPRRDDFSALPAPLLTSLGALTFVLDVALDAQRRLAQADPDKVRSDMSERGFYLQVPPSVASLMPRHYD
What are the official names of this protein?
YcgL domain-containing protein Smlt4554.
Protein: BDF1_SCHPO
Sequence: MSSESRENEVKAETKDEIANDGSPQLNGDNNIQSSDGHNDENEESLSRKRDSSGATVGDLKQEEKESMPKKEPEPTVKKIRGSGMPPPQQKYCLAIVRQLKRTKNSAPFKVPVDPIKQNIPDYPTIVKNPMDLGTIEKKLTSYEYSVPQEFIDDMNLMFSNCFLYNGTESPVGSMGKALQEVFERQLKQLPDAEQPAAAPVKKSKQKSASTAPPRTRRNSSVSSTSASVAASTAPKAASPAVLPEGKPRRRKNNSQMRFCSTVLKELYKRQYESFAFPFYQPVDPVACDCPDYFDVIKEPMDLSTIQSKLNKNEYSTLEEFESDILLMFNNCFTYNPPGTPVHVMGRQLENVFKEKWEARPKFDDATLVKQQEAETDALFDNGEEEEALMSEEEINGAKFAAVDKQISMLQDTLEAMKAKKMNRMRKPRRRDLTKEYGPITYAMQNELAERCNYLSAEQLSNVAEILREEMPWLRDTDEIEIDVGNMKPEVFHRIYRYVCKPDADSSEPASPVLMPTKPEKKKGRVLSETEQAEKIRRLQQQLDRFAGKTSPTSPESNNAANVSDSESDNESESSESA
What is the function of this protein?
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
What are the official names of this protein?
SWR1 complex bromodomain subunit bdf1.
What are the subcellular locations of this protein?
Nucleus.
Protein: RIMM_MAGSA
Sequence: MGPRVRVGVIVGVHGVRGAVRIKSFTEDPADIGFYSPVENEAGSIKYRLKVTGEVKGLVIATLDGIGDRDAAEALKGTELWVARERLPRLAEDEFLYSDLIGLVAEGVDGKRLGIVKAVADYGAGDVLDIKLEPKGDMMVPFTQASVPEVDIAGGRLVVVPPVYAPDENEEKSGGA
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTRA_SHIFL
Sequence: MPRSTWFKALLLFVALWAPLSQAETGWQPIQETIRKSDKDNRQYQAIRLDNGMVVLLVSDPQAVKSLSALVVPVGSLEDPEAYQGLAHYLEHMSLMGSKKYPQADSLAEYLKMHGGSHNASTAPYRTAFYLEVENDALPGAVDRLADAIAEPLLDKKYAERERNAVNAELTMARTRDGMRMAQVSAETINPAHPGSKFSGGNLETLSDKPGNPVQQALKDFHEKYYSANLMKAVIYSNKPLPELAKMAADTFGRVPNKESKKPEITVPVVTDAQKGIIIHYVPALPRKVLRVEFRIDNNSAKFRSKTDELITYLIGNRSPGTLSDWLQKQGLVEGISANSDPIVNGNSGVLAISASLTDKGLANRDQVVAAIFSYLNLLREKGIDKQYFDELANVLDIDFRYPSITRDMDYVEWLADTMIRVPVEHTLDAVNIADRYDAKAVKERLAMMTPQNARIWYISPKEPHNKTAYFVDAPYQVDKISAQTFADWQKKAADIALSLPELNPYIPDDFSLIKSEKKYDHPELIVDESNLRVVYAPSRYFASEPKADVSLILRNPKAMDSARNQVMFALNDYLAGLALDQLSNQASVGGISFSTNANNGLMINANGYTQRLPQLFQALLEGYFSYTATEEQLEQAKSWYNQMMDSAEKGKAFEQAIMPAQMLSQVPYFSRDERRKILPSITLKEVLAYRDALKSGARPEFMVIGNMTEAQATTLARDVQKQLGADGSEWCRNKDVVVDKKQSVIFEKAGNSTDSALAAVFVPTGYDEYTSSAYSSLLGQIVQPWFYNQLRTEEQLGYAVFAFPMSVGRQWGMGFLLQSNDKQPSFLWERYKAFFPTAEAKLRAMKPDEFAQIQQAVITQMLQAPQTLGEEASKLSKDFDRGNMRFDSRDKIVAQIKLLTPQKLADFFHQAVVEPQGMAILSQISGSQNGKAEYVHPEGWKVWENVSALQQTMPLMSEKNE
What is the function of this protein?
Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.
What are the official names of this protein?
Protease 3, Pitrilysin, Protease III, Protease pi.
What is the protein family that this protein belongs to?
Belongs to the peptidase M16 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GSLG1_CHICK
Sequence: MAPCGRVRSRCPGPALLLLLALAARPALAGPPAAALQAGPGLNAAGQPAQGAAPGAAGPRGARGGGGGSGGGWKLSEEAVCREDVVRLCSKHSWANNLAVLECLQDVREPDNEISSDCNHLLWNYKLNLTTDPKFESVAREVCKSTIAEIKECADEPVGKGFLVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKADINLLKCGSIRPGEKDAHSQGEVVACLEKGLVKEAEENDPRVQVSDQCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCRDALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEKGNVGLNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDVVLYRKCQGDASRLCHTHGWNETSELMPPGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCMIDLGKWCSEKTETGQELECLQDHLDDLVSDCRDIVGNLTELESEDIQIEALLMRACEPIIQTFCHEVADNQIDSGDLMECLIQNKHQKEMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQDAKEHRVSLKCRKQLRVEELEMTEDIRLEPELYEACKSDIKNYCQNVPYGNAQIIECLKEIKKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKNMLQCLKQNKNSEVMDPKCKQMITKRQITQNTDYRLNPVLRKACKADIPKFCQNILNRAKDDTELEGQVISCLKLKYADQRLSPDCEDQIRVIIQESALDYRLDPQLQMHCSEEISSLCAEEAAAQEQTGQVEECLKVNLLKIKTEMCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAIPPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPAEGFSDLAMQVMTSPSKNYILSVITVGICVLFLIGLMCGRITKRVTRELKDR
What is the function of this protein?
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils) (By similarity).  Binds fibroblast growth factor (FGF).  May be involved in intracellular FGF trafficking and the regulation of cellular responses to FGFS (PubMed:1448090).
What are the official names of this protein?
Golgi apparatus protein 1, Cysteine-rich fibroblast growth factor receptor.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type I membrane protein. Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Golgi medial cisternae. Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation.
Protein: TNIK_HUMAN
Sequence: MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
What is the function of this protein?
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway.  Recruited to promoters of Wnt target genes and required to activate their expression.  May act by phosphorylating TCF4/TCF7L2.  Appears to act upstream of the JUN N-terminal pathway.  May play a role in the response to environmental stress.  Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.  More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading.  Phosphorylates SMAD1 on Thr-322.
What are the official names of this protein?
TRAF2 and NCK-interacting protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Protein: THIC_ECO55
Sequence: MSATKLTRREQRARAQHFIDTLEGTAFPNSKRIYITGTHPGVRVPMREIQLSPTLIGGSKEQPQYEENEAIPVYDTSGPYGDPQIAINVQQGLAKLRQPWIDARGDTEELTVRSSDYTKARLADDGLDELRFSGVLTPKRAKAGRRVTQLHYARQGIITPEMEFIAIRENMGRERIRSEVLRHQHPGMSFGARLPENITAEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLLEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHQENFLYQHFREICEICAAYDVSLSLGDGLRPGSIQDANDEAQFAELHTLGELTKIAWEYDVQVMIEGPGHVPMQMIRRNMTEELEHCHEAPFYTLGPLTTDIAPGYDHFTSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPFTARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAATQTIEMGMADMSENFRARGGEIYLRKEEA
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: IPNS_AMYLA
Sequence: MKMPSAEVPTIDVSPLFGDDAQEKVRVGQEINKACRGSGFFYAANHGVDVQRLQDVVNEFHRTMSPQEKYDLAIHAYNKNNSHVRNGYYMAIEGKKAVESFCYLNPSFSEDHPEIKAGTPMHEVNSWPDEEKHPSFRPFCEEYYWTMHRLSKVLMRGFALALGKDERFFEPELKEADTLSSVSLIRYPYLEDYPPVKTGPDGEKLSFEDHFDVSMITVLYQTQVQNLQVETVDGWRDLPTSDTDFLVNAGTYLGHLTNDYFPSPLHRVKFVNAERLSLPFFFHAGQHTLIEPFFPDGAPEGKQGNEAVRYGDYLNHGLHSLIVKNGQT
What is the function of this protein?
Removes, in the presence of oxygen, 4 hydrogen atoms from delta-L-(alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to form the azetidinone and thiazolidine rings of isopenicillin.
What are the official names of this protein?
Isopenicillin N synthase, IPNS.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: TOLB_XANOP
Sequence: MKKPLRWLAALTVLLLPLSALAQQQGLTIDIVGGSASATPIAVIPMPYQGSDTAPQTDVSAVVGADLDRSGQFRTLPAAQIVEKPTRGTEVQFQTWRTLKQNYIVVGRVMDAGEGAYRVEYELFDVAKGERMLGLAMTARANAMRDVSHQMADAIYEKITGVRGAFWTRIAYVTASGKGGAMRYALMVADSDGYNPQTIVRSAEPLLSPNWSPDGKKLAYVSFERGNSSIYLQDIATGARELVSSFRGINGAPSFSPDGRRLALALSRSGNPEIYVMDLGSKQLTQLTNHFGIDTEPTWAPDGGSIYFTSDRGGRPQIYQVAASGGSANRVTFQGNYNATASVSFDGKKIAVAQGSGNTYRIAMMDRSLGSPSWSTLSPGSLDESPSFAPNASMVLYAAREGGRGVLYAVSSDARVRQRLVLADGDVREPAWGPYRTAH
What is the function of this protein?
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
What are the official names of this protein?
Tol-Pal system protein TolB.
What is the protein family that this protein belongs to?
Belongs to the TolB family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GLGA_SYNR3
Sequence: MRILFAAAECAPMVKVGGMGDVVGSLPPALAELGHDVRVIMPGYGKLWSQLDVPSEPIWRAQTMGTDFAVYETRHPKTGLTIYLVGHPVFDGERIYGGEDEDWRFTFFASATSEFAWNAWKPQVLHCHDWHTGMIPVWMHQDPEISTVFTIHNLKYQGPWRWKLERMTWCPWYMQGDHTMAAALLYADRVNAVSPTYAQEIRTPEYGEQLEGLLNYISGKLRGILNGIDVEAWNPATDSRIPATYSTADLSGKAVCKRALQERMGLQVNPDTFVIGLVSRLVDQKGVDLLLQVAERFLAYTDTQIVVLGTGDRHLESGLWQMASQHSGRFASFLTYDDDLSRLIYAGSDAFLMPSRFEPCGISQLLSMRYGTIPVVRRVGGLVDTVPPYVPATQEGNGFCFDRYEAIDLYTALVRAWEAYRHQDSWQQLMKRVMQVDFSWARSALEYDRMYRDVCGMKEPTPEADAVAAFSIPQPPEQQAARAAAEAADPNPQRRFNPLGLLRRNGG
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: G3PC_PETHY
Sequence: MAKIKIGINGFGRIGRLVARVALQRDDVELVAVNDPFISVEYMTYMFKYDSVHGQWKHHELKAKDDKTLLFGEKPVTVFGIRNPEEIPWGEAGADYVVESTGVFTDKDKAAAHLKGGAKKVIISAPSKDAPMFVVGVNEKEYKSDLTVVSNASCTTNCLAPLAKVINDRFGIVEGLMTTVHSMTATQKTVDGPSAKDWRGGRAASFNIIPSSTGAAKAVGKVLPALNGKLTGMAFRVPTVDVSVVDLTVRLEKEATYDEIKAAIKEESEGKLKGIPGHTEDDVVSTDFIGDNRSSIFDAKAGIALSKNFVKLVSWYDNEMGYSTRVVDLIKHIASVE
What is the function of this protein?
Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.  Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BBS12_HUMAN
Sequence: MVMACRVVNKRRHMGLQQLSSFAETGRTFLGPLKSSKFIIDEECHESVLISSTVRLLESLDLTSAVGQLLNEAVQAQNNTYRTGISTLLFLVGAWSSAVEECLHLGVPISIIVSVMSEGLNFCSEEVVSLHVPVHNIFDCMDSTKTFSQLETFSVSLCPFLQVPSDTDLIEELHGLKDVASQTLTISNLSGRPLKSYELFKPQTKVEADNNTSRTLKNSLLADTCCRQSILIHSRHFNRTDNTEGVSKPDGFQEHVTATHKTYRCNDLVELAVGLSHGDHSSMKLVEEAVQLQYQNACVQQGNCTKPFMFDISRIFTCCLPGLPETSSCVCPGYITVVSVSNNPVIKELQNQPVRIVLIEGDLTENYRHLGFNKSANIKTVLDSMRLQEDSSEELWANHVLQVLIQFKVNLVLVQGNVSERLIEKCINSKRLVIGSVNGSVMQAFAEAAGAVQVAYITQVNEDCVGDGVCVTFWRSSPLDVVDRNNRIAILLKTEGINLVTAVLTNPVTAQMQIKEDRFWTCAYRLYYALKEEKVFLGGGAVEFLCLSCLHILAEQSLKKENHACSGWLHNTSSWLASSLAIYRPTVLKFLANGWQKYLSTLLYNTANYSSEFEASTYIQHHLQNATDSGSPSSYILNEYSKLNSRIFNSDISNKLEQIPRVYDVVTPKIEAWRRALDLVLLVLQTDSEIITGHGHTQINSQELTGFLFL
What is the function of this protein?
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.  As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638).  Involved in adipogenic differentiation (PubMed:19190184).
What are the official names of this protein?
Bardet-Biedl syndrome 12 protein.
What is the protein family that this protein belongs to?
Belongs to the TCP-1 chaperonin family. BBS12 subfamily.
What are the subcellular locations of this protein?
Cell projection, cilium. Note=Located within the basal body of the primary cilium of differentiating preadipocytes.
Protein: YNL6_CAEEL
Sequence: MRISLPVAEAAAAGGRAGKHGKAITFLTPDDTAVYFDLKQVKIVDGHLPTHVFSLNCLRRYARMDSRNMMLHGANLDNSHLDVKVNFLFENFKHFSVFLKLTKSSK
What are the official names of this protein?
Uncharacterized protein R12B2.6.
Protein: PFDB_METHJ
Sequence: MQNISPKVQNQINMLQQMQQQMQTILSQKSQYELAAQEARRAVEELKETDDSAAVYMNVGTVVMQKPKSEVISKVTEKIETLEIRIRSIEKQEKMLQEKFEKLQSQVRSEIEGRKTPDAN
What is the function of this protein?
Molecular chaperone capable of stabilizing a range of proteins.  Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
What are the official names of this protein?
Prefoldin subunit beta, GimC subunit beta.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
What are the subcellular locations of this protein?
Cytoplasm.