PharMolix/UniProtQA huggingface dataset:
Protein: TSAD_LEVBA
Sequence: MSPTEKRNLILAFESSCDETSVAVIEDGHRILSNIVATQIKSHQRFGGVVPEVASRHHIEEITLCIEDALAEAQVGYDDLTAVAVTYGPGLVGALLIGVTAAKTVAFAHNLPLIPVNHMAGHIYAARYVEPIEFPAMALLVSGGHTELVYMPAENQFEIIGETRDDAAGEAYDKVGRVMGVNYPAGKTVDDWAHQGHDTFKFPRAMEKDDNFDFSFSGLKSAFINTTHHADQIGETLNKQDLAASFQQAVVDVLAEKTQRALADYPVKQLILAGGVAANRGLRERLAADLASNPTTHLVKAPLKLCGDNAAMIGAFAYVAYQHGVLADTSLNADPSLEFDWVADPVK
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TB1RA_XENLA
Sequence: MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALAPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQQTAAAAAAAAAAAATPNNQQPPAKNGENTANGEENGGHALANNHTDMMEVDGDVEIPSSKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKHDTCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK
What is the function of this protein?
F-box-like protein which acts as an integral component of the N-CoR transcriptional corepressor complex.  Probably regulates transcription activation mediated by nuclear receptors.  May mediate the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of the N-CoR complex, thereby allowing cofactor exchange and transcription activation (By similarity).
What are the official names of this protein?
F-box-like/WD repeat-containing protein TBL1XR1-A, Nuclear receptor corepressor/HDAC3 complex subunit TBLR1-A, TBL1-related protein 1-A, xTBLR1, Transducin beta-like 1X-related protein 1-A.
What is the protein family that this protein belongs to?
Belongs to the WD repeat EBI family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEPA_BURP0
Sequence: MDHIRNFSIIAHIDHGKSTLADRIIQLCGGLSDREMESQVLDSMDLERERGITIKAQTAALTYRARDGKVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTAIELGVEVVPVLNKIDLPAANPENAIAEIEDVIGIDAMDAVRCSAKTGLGVEDVLESLIAKVPPPKGDPDAPLQALIIDSWFDNYVGVVMLVRIVNGTLRPKERIKLMATDAQYAVEHVGVFTPKSRNLESLSAGQVGFIISGIKELTAAKVGDTVTHATKPAPEPLPGFKEVKPQVFAGLYPVEANQYDALRESLEKLKLNDASLQYEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDMDLITTAPTVVYEVVQSDGTTIMVENPAKMPEPARIAEIREPIVTVNLYMPQDYVGSVITLCEQKRGTQINMQYHGRQVQLTYEIPMAEIVLDFFDRLKSVSRGYASMDYEFKEYRTSDVVKVDMLINGDKVDALSIIVHRSQSQYRGREVAAKMREIIPRQMYDVAIQAAIGAHIIARENIKALRKNVLAKCYGGDITRKKKLLEKQKEGKKRMKQVGSVEIPQEAFLAILRVEDK
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ALLC_ACIAD
Sequence: MATLLAPAFELPTSLHSLTNLADSRIGAQIVECSDDFFAEAKRMLQFEAPIFVEDKFDDHGKWMDGWETRRKRHAGYDWCIVKLGVAGKIKAVDIDTTFFTGNYPASASLEGCYAPNGNTQEALWQPLLGNSILGPSQHHVFDVQNDAIFTHIRLNIFPDGGVARLRIYGDVQIQITDTDQTLDLLALQNGGRVIAYSDAHFGHPRNLINPGRGVNMGDGWETKRRRAPGFDWCLLALGQAGKIEKIEIDTAHFKGNYPAQVSIQAIYIEDATDPQLIPQSMFWPFLLEAQDMQMDHIHSYLNEVLAHEKVSHIRVNMIPDGGISRVRLWGKVV
What are the official names of this protein?
Probable allantoicase, Allantoate amidinohydrolase.
What is the protein family that this protein belongs to?
Belongs to the allantoicase family.
Protein: ILVD_CORDI
Sequence: MFPLRSRVTTVGRNAAGARALWRATGTKDNEFGKPIVAIVNSYTQFVPGHVHLKNVGDIVAEAVRAAGGVPKEFNTIAVDDGIAMGHGGMLYSLPSREIIADSVEYMVNAHTADAMVCISNCDKITPGMLNAALRLNIPAVFVSGGPMEAGKAVVADGIAHAPTDLITAITASAKDSVNDDQLLSIEQSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTTLATHTARRELFETAGKLVVDLCQRYYGEEDESVLPRNIATKKAFINAMALDMAMGGSTNTVLHTLAAAQEGEIDFDLSDIDALSHRIPCLSKVAPNGNYHIEDVHRAGGIPAILGELRRRDLLEKGVHTVLYKEMDSWLDDWDIRGGKATDKAIELFHAAPGGVRTTEPFSQSNRWDSLDTDQARGCIHDVDHAYSADGGLVILRGNLAPDGAVVKAAGVDESIWTFSGPARVVESQEEAVSIILDKQVQPGDVVVIRYEGPAGGPGMQEMLHPTSFLKGAGLGKACALITDGRFSGGTSGLSIGHISPEAAHGGLIGLVENGDTITIDIRNRSLNLDVDDAVIEQRRAAMLEREKPWTPTNRNRPVSKALRAYASMATSADKGAVRQLD
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: QUEA_PROMT
Sequence: MLDQKDNLLSSYNYDLPNELIAQSPTKSRHDAKLMIVKDGLDDSLNLVHAKVWDIKDILKPADLLVVNNTRVVKARLKIRLSGGGAGELLLMEPRGDGRWLCLGRPARRMRGGDQLWLDMSRDNSLILKVIDKDERTGGRIIQFSNEFTSWTEMENILDLCGEVPLPPYIDKDKSSDHEESYQTRFASKPGAIAAPTAGLHLSDELIENLKTRGIKIAQITLHVGLGTFRPLEKEDLSQLHLHSEWIEVTEETIKAITNCKEDGGKVFAVGTTSVRALEAAYLSGRGALKPYEGKVDLVIKPGFKFSVIDGLLTNFHLPKSSLLLLVSALIGRKRMLKLYKQAISNKYRFFSYGDAMLITPESVI
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAB_SHIBS
Sequence: MEISWGRALWRNFLGQSPDWYKLALIIFLIVNPLIFLISPFVAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVFIGMTSAEHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMLLSLSFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRTEDTDLQDDSHIDKHYKVVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLICGLLTCLLVEKLRWFGYGETLPEKVREVLQQFDDQSRHQRTRQDKIRLIVQAIIGVWLVTALALHLAEVGLIGLSVIILATSLTGVTDEHAIGKAFTESLPFTALLTVFFSVVAVIIDQQLFSPIIQFVLQASEHAQLSLFYIFNGLLSSISDNVFVGTIYINEAKAAMESGAITLKQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTLVLTLVGLLCVEFTLAPVTEWFMQMGWIATL
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaB, Sodium/proton antiporter NhaB.
What is the protein family that this protein belongs to?
Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COLG_HATHI
Sequence: MKKNILKILMDSYSKESKIQTVRRVTSVSLLAVYLTMNTSSLVLAKPIENTNDTSIKNVEKLRNAPNEENSKKVEDSKNDKVEHVKNIEEAKVEQVAPEVKSKSTLRSASIANTNSEKYDFEYLNGLSYTELTNLIKNIKWNQINGLFNYSTGSQKFFGDKNRVQAIINALQESGRTYTANDMKGIETFTEVLRAGFYLGYYNDGLSYLNDRNFQDKCIPAMIAIQKNPNFKLGTAVQDEVITSLGKLIGNASANAEVVNNCVPVLKQFRENLNQYAPDYVKGTAVNELIKGIEFDFSGAAYEKDVKTMPWYGKIDPFINELKALGLYGNITSATEWASDVGIYYLSKFGLYSTNRNDIVQSLEKAVDMYKYGKIAFVAMERITWDYDGIGSNGKKVDHDKFLDDAEKHYLPKTYTFDNGTFIIRAGDKVSEEKIKRLYWASREVKSQFHRVVGNDKALEVGNADDVLTMKIFNSPEEYKFNTNINGVSTDNGGLYIEPRGTFYTYERTPQQSIFSLEELFRHEYTHYLQARYLVDGLWGQGPFYEKNRLTWFDEGTAEFFAGSTRTSGVLPRKSILGYLAKDKVDHRYSLKKTLNSGYDDSDWMFYNYGFAVAHYLYEKDMPTFIKMNKAILNTDVKSYDEIIKKLSDDANKNTEYQNHIQELADKYQGAGIPLVSDDYLKDHGYKKASEVYSEISKAASLTNTSVTAEKSQYFNTFTLRGTYTGETSKGEFKDWDEMSKKLDGTLESLAKNSWSGYKTLTAYFTNYRVTSDNKVQYDVVFHGVLTDNADISNNKAPIAKVTGPSTGAVGRNIEFSGKDSKDEDGKIVSYDWDFGDGATSRGKNSVHAYKKAGTYNVTLKVTDDKGATATESFTIEIKNEDTTTPITKEMEPNDDIKEANGPIVEGVTVKGDLNGSDDADTFYFDVKEDGDVTIELPYSGSSNFTWLVYKEGDDQNHIASGIDKNNSKVGTFKSTKGRHYVFIYKHDSASNISYSLNIKGLGNEKLKEKENNDSSDKATVIPNFNTTMQGSLLGDDSRDYYSFEVKEEGEVNIELDKKDEFGVTWTLHPESNINDRITYGQVDGNKVSNKVKLRPGKYYLLVYKYSGSGNYELRVNK
What is the function of this protein?
Clostridial collagenases are among the most efficient degraders of eukaryotic collagen known; saprophytes use collagen as a carbon source while pathogens additionally digest collagen to aid in host colonization.  Has both tripeptidylcarboxypeptidase on Gly-X-Y and endopeptidase activities; the endopeptidase cuts within the triple helix region of collagen while tripeptidylcarboxypeptidase successively digests the exposed ends, thus clostridial collagenases can digest large sections of collagen (PubMed:3002446).  Active on soluble type I collagen, insoluble collagen, azocoll, soluble PZ-peptide (all collagenase substrates) and gelatin (PubMed:9922257).  The full-length protein has collagenase activity, while the in vivo derived C-terminally truncated shorter versions only act on gelatin (PubMed:9922257).  In vitro digestion of soluble calf skin collagen fibrils requires both ColG and ColH; ColG forms missing the second collagen-binding domain are also synergistic with ColH, although their overall efficiency is decreased (PubMed:18374061, PubMed:22099748).  The activator domain (residues 119-388) and catalytic subdomain (389-670) open and close around substrate using a Gly-rich hinge (387-397), allowing digestion when the protein is closed (PubMed:21947205, PubMed:23703618).  Binding of collagen requires Ca(2+) and is inhibited by EGTA; the collagen-binding domain (CBD, S3a plus S3b) specifically recognizes the triple-helical conformation made by 3 collagen protein chains in the triple-helical region (PubMed:11121400).  Isolated CBD (S3a plus S3b) binds collagen fibrils and sheets of many tissues (PubMed:11913772).
What are the official names of this protein?
Collagenase ColG, Class I collagenase, Gelatinase ColG, Microbial collagenase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M9B family. Collagenase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: NDB4S_MESSU
Sequence: MKTQIVILIVAVLFLQLVSQSDAFLKGIIDTVSNWLGKRGLKNLDQYNDLFDGEISDADIKFLKDLMR
What is the function of this protein?
Amphipathic peptide that shows no antibacterial activity even at 50 uM but shows a low hemolytic activity against human erythrocytes.
What are the official names of this protein?
Amphipathic peptide CT1, VsCT1, Non-disulfide-bridged peptide 5.11, NDBP-5.11.
What is the protein family that this protein belongs to?
Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.
What are the subcellular locations of this protein?
Secreted. Target cell membrane. Note=Forms a helical membrane channel in the prey.
Protein: KIF5A_PONAB
Sequence: MAETNNECSIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKPYVFDRVFPPNTTQEQVYHACAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSGPEEILDVIDEGKSNRHVAVTNMNEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQQELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVERHRKMEVTGRELSSCQLLISQHEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEEHEKSTKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEGAMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPGHYPASSPTNPYGTRSPECISYTNSLFQNYQNLYLQATPSSTSDMYFANSCTGSGATSSGGPLASYQKANMDNGNATDIKDNRSDLPCGYEAEDQAKLFPLHQETAAS
What is the function of this protein?
Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).  Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner.  The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons.  Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
What are the official names of this protein?
Kinesin heavy chain isoform 5A.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Perikaryon. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region.
Protein: BEST2_CAEEL
Sequence: MTINYHKEIKTSHTWKFFVLLFRWKGSIWKAIYMETIIFLICYGIISVVYRTAMSEPSQRTFESVIRYCDKRLSFIPLEFVLGFFVTIVVDRWTKLWRTVGFIDDVCLLANLYVRGTSEKAIIYRRNIARYCALTQLLVFRDVSMRTRRRFPTMETVVAAGFMSKDELDLYNSYTTKNNSRLGKKYWIPANWALCMTYKARKDGYIESDYFKAQMEGEIRTWRTNIEWVCNYDWVPLPLMYPQLVCLAVNLYFLVSIIARQLVIEKHKMVDEVDVYFPVMTFLQFIFYMGWLKVIEVMLNPFGEDDDDFETNALIDRNITMGLKMVDNTMKTPELLKDQFFDEVLVSLLYSEESSQISNYHYHGSTSEVHLEQKCSSVRMIPHSQSEYTLKHMRKQTLSRSVLPDVNENERWKIPTSLEKF
What is the function of this protein?
Forms chloride channels.
What are the official names of this protein?
Bestrophin homolog 2.
What is the protein family that this protein belongs to?
Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS11_GLOVI
Sequence: MAKPTRGGQKKKVRRNVPSGVAHIQSTFNNTIVTIADTVGDVISWASAGSSGFKGAKKGTPFAAQQAAESAGRRAIDSGMRQCEVMVSGPGAGRETAIRALQAVGLEITLIRDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: MTOX_SALSV
Sequence: MKYDLIIIGSGSVGAAAGYYATRAGLKVLMTDAHMPPHQQGSHHGDTRLIRHAYGEGEKYVPLVLRAQALWDELSTHNEEPIFVRSGVVNLGPADSAFLANVARSAQQWQLNVERLDATALMTRWPEIRVPDNYIGLFEADSGFLRSELAITTWLRLAREAGCAQLFNSPVSHIHHDDNGVTIETSEGCYHASKALISAGTWVKALVPELPVQPVRKVFAWFKADGRYSTKNRFPAFTGEMPNGDQYYGFPAENDELKIGKHNGGQLIQAPEERKPFAAVASDGAEAFPFLRNVLPGIGGCLHGAACTYDNSPDEDFIIDTLPGHENTLVITGLSGHGFKFAPVLGEIAADFALGKTPSFDLTPFRLSRFSQ
What is the function of this protein?
Catalyzes the oxidative demethylation of N-methyl-L-tryptophan.
What are the official names of this protein?
N-methyl-L-tryptophan oxidase, MTOX.
What is the protein family that this protein belongs to?
Belongs to the MSOX/MTOX family. MTOX subfamily.
Protein: ATPB_STRP3
Sequence: MSSGKIAQVVGPVVDVMFASGDKLPEINNALIVYKDSDKKQKIVLEVALELGDGMVRTIAMESTDGLTRGLEVLDTGRAISVPVGKETLGRVFNVLGETIDLEEPFAEDVDRQPIHKKAPSFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTQKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLTQMGIYPAVDPLASSSRALSPEIVGEEHYAVATEVQRVLQRYRELQDIIAILGMDELSDEEKTLVGRARRIQFFLSQNFNVAEQFTGLPGSYVPVAETVRGFKEILEGKYDDLPEDAFRSVGPIEDVIKKAEKMGF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: KCNG3_RAT
Sequence: MTFGRGGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTHTFHAAEELGREQPRPTGPEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRAAAADNRSLDDRSRYSASPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFASIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSAEFLN
What is the function of this protein?
Potassium channel subunit that does not form functional channels by itself.  Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.
What are the official names of this protein?
Potassium voltage-gated channel subfamily G member 3, Voltage-gated potassium channel subunit Kv10.1, Voltage-gated potassium channel subunit Kv6.3.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1.
Protein: CIR1_MOUSE
Sequence: MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGVKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQDYVASDCEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKKSDKKKKKLQKSKNKHKKRKNKSPSSSSSSSSSSSSSSSSSSSSSSSSETSDSSSESDNKEKKREKEKRKKKKKTKCSESKSSDCKEDKPKNMLYEELSSSHSDRGKAQEKLRFPKQESSGENSMWVHSASDRTSRSHRHSPEKKGSDRNRGIRSRSRSRAESSRRSRSRSPYRQKHREVRSRPHRSPSEEQKGRKGTRSHGEGDHRREHVR
What is the function of this protein?
Regulates transcription and acts as corepressor for RBPJ.  Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC).  Required for RBPJ-mediated repression of transcription (By similarity).  May modulate splice site selection during alternative splicing of pre-mRNAs.
What are the official names of this protein?
Corepressor interacting with RBPJ 1, CBF1-interacting corepressor.
What are the subcellular locations of this protein?
Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Protein: RS21_PROM9
Sequence: MTQVTVGENEGIESALRRFKRQVSKSGIFADLKRLRHHETPIEKYKRKLQQRRKARRR
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ZFAN5_HUMAN
Sequence: MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADTSLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSTSQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI
What is the function of this protein?
Involved in protein degradation via the ubiquitin-proteasome system.  May act by anchoring ubiquitinated proteins to the proteasome.  Plays a role in ubiquitin-mediated protein degradation during muscle atrophy.  Plays a role in the regulation of NF-kappa-B activation and apoptosis.  Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA.  Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner.  Overexpression sensitizes cells to TNF-induced apoptosis.  Is a potent inhibitory factor for osteoclast differentiation.
What are the official names of this protein?
AN1-type zinc finger protein 5, Zinc finger A20 domain-containing protein 2, Zinc finger protein 216.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEUD_HALH5
Sequence: MEPLKTHTGTIAVLDRVNVDTDQIIPKQFLKRVERTGFGQFLFFDWRFLPNGEDNPDFELNQPHAKQGTILVAGHNFGCGSSREHAPWAIKDYGFRVVIAPSFADIFYNNCFKNGILPVKLKQEEVTALMEKGKDTAYSLTVNLEAQTVTSEDGFEATFEIDGYWKEMLINGWDEIGLTLRYEEQIKQFEASRV
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: CSN5A_ARATH
Sequence: MEGSSSAIARKTWELENNILPVEPTDSASDSIFHYDDASQAKIQQEKPWASDPNYFKRVHISALALLKMVVHARSGGTIEIMGLMQGKTEGDTIIVMDAFALPVEGTETRVNAQSDAYEYMVEYSQTSKLAGRLENVVGWYHSHPGYGCWLSGIDVSTQMLNQQYQEPFLAVVIDPTRTVSAGKVEIGAFRTYPEGHKISDDHVSEYQTIPLNKIEDFGVHCKQYYSLDITYFKSSLDSHLLDLLWNKYWVNTLSSSPLLGNGDYVAGQISDLAEKLEQAESQLANSRYGGIAPAGHQRRKEDEPQLAKITRDSAKITVEQVHGLMSQVIKDILFNSARQSKKSADDSSDPEPMITS
What is the function of this protein?
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses.  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF.  In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins.  It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity).  The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes.  The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.  Involved in CSN's deneddylation/derubylation activity (PubMed:15486099).  Required for the deneddylation of all cullins (PubMed:15923347, PubMed:17307927).  Essential for the structural integrity of the CSN holocomplex (PubMed:17307927).
What are the official names of this protein?
COP9 signalosome complex subunit 5a, Signalosome subunit 5a, Jun activation domain-binding homolog 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: TOX2_RAT
Sequence: MSDGNPELLSTSQTYNSQGESNEDYEIPPITPPNLPEPSLLHLGDHEAGYHSLCHGLAPNGLLPAYSYQAMDLPAIMVSNMLAQDGHLLSGQLPTIQEMVHSEVAAYDSGRPGPLLGRPAMLASHMSALSQSQLISQMGLRSGIAHSSPSPPGSKSATPSPSSSTQEEESDAHFKISGEKRPSTDPGKKAKNPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPSATFGDVSKIVASMWDSLGEEQKQAYKRKTEAAKKEYLKALAAYRASLVSKSPPDQGEAKNAQANPPAKMLPPKQPMYAMPGLASFLTPSDLQAFRSAASPASLARTLGSKALLPGLSTSPPPPSFPLSPSLHQQLPLPPHAQGTLLSPPLSMSPAPQPPVLPAPMALQVQLAMSPSPPGPQDFPHISDFPSGSGSRSPGPSNPSSSGDWDGSYPSGERGLGTCRLCRSSPPPTTSPKNLQEPSAR
What is the function of this protein?
Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.
What are the official names of this protein?
TOX high mobility group box family member 2, Granulosa cell HMG box protein 1, GCX-1.
What are the subcellular locations of this protein?
Nucleus.