PharMolix/UniProtQA huggingface dataset:
Protein: GET1_TALSN
Sequence: MISFLLLIFLIQLAIYIVNTIGASTVDDLLWILYLRLPSSISKDARKHGELKRDVVQLKREMNATSSQDEFAKWAKLRRRHDKAMEEYEAMNRSMGSRKTSFQYSVKIARWLTLNGPRLFIQFYYTKTPVFDLPPGWFPYPVEWILSFPRAPLGTVSIQVWSSACATAISLTGNVVIAALQKSGQASMRQAQAIPAGKSE
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
What are the official names of this protein?
Protein get1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CRP_THET8
Sequence: MKGSPLFHGLAPEEVDLALSYFQRRLYPQGKPIFYQGDLGQALYLVASGKVRLFRTHLGGQERTLALLGPGELFGEMSLLDEGERSASAVAVEDTELLALFREDYLALIRRLPLVAHNLAALLARRLREADLELDLLSFEEARNRVAYALLKLLRQGLGPLFQIRHHELAALAGTSRETVSRVLHALAEEGVVRLGPGTVEVREAALLEEIAFGLA
What is the function of this protein?
Activates transcription.  Positively regulates six promoters upstream of the TTHB186, TTHB147, TTHB178, TTHB159, TTHA0771 and TTHA0176 genes in a cAMP-dependent manner.  Regulated genes include clustered regularly interspaced short palindromic repeat (CRISPR) associated (Cas) genes, and the genes encoding a putative transcriptional regulator, a protein containing the exonuclease III-like domain of DNA polymerase, a GCN5-related acetyltransferase homolog, and some T. thermophilus-specific proteins of unknown function.  The consensus DNA-binding site of this transcriptional regulator is 5'-(CT)NNG(G/T)(G/T)C(A/C)N(A/T)NNTCACAN(G/C)(G/C)-3' in which N is G, A, T or C.
What are the official names of this protein?
Cyclic AMP receptor protein, Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein TTHA1437, CRP/FNR superfamily protein TTHA1437, cAMP receptor protein, CRP.
Protein: RECF_BREBN
Sequence: MFLKNLSLTNYRNYETMSLSFDGPIQLFIGNNAQGKTNALESIYVLALAKSHRTPRDKELISWDADYATIRSDVLRRYGSVRLELQLTTKGKRAKINGMEQQKLSAYVGALNVVMFAPEDLSIVKGAPAQRRRFIDMEIGQVSPTYLYYLSNYNKVLAQRNQLLKDLAMKKSNSLEMLAIWNTQLADLAVKLLRKRFEFIRKLETWAQEIHTGITDGRERLSLHYVNSSPVTEEMTIDQAVDKMLAAYEEVRDREIMRGSTLIGPHRDDFSLKVNNMDVQTYGSQGQQRTSALSIKLAEIELIKEEVGEYPVLLLDDVLSELDEHRQTLLLETIQDRVQTFVSTTGVEGLKHQVLQQASRFYVREGKISGER
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRCB_PHEZH
Sequence: MQALLLVGAGGAAGAVARYLLGVQALRWLGPGWPYGTFAANILGGFLMGLLAGGLAHRGGAGQETWRLLLGVGALGGFTTFSAYSLEVALMIERRAYGQAFAYSLGSVALAVAALFAGLLLARRVFA
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: YACG_YERPG
Sequence: MESEQIQVNCPTCGKVVIWGEQSPFRPFCCKRCQLIDLGEWADEEKRIPSDTELSDSDEWSEEDPLKH
What is the function of this protein?
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA.  Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
What are the official names of this protein?
DNA gyrase inhibitor YacG.
What is the protein family that this protein belongs to?
Belongs to the DNA gyrase inhibitor YacG family.
Protein: MYD88_PONPY
Sequence: MAAGGPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAADWTALAEEMDFEYLEIRQLETHADPTGRLLDAWQGRPGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQEEAEKPLQVAAVDSSVPRTAELAGITTLDDPLGHMPERFDAFICYCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFWTRLAKALSLP
What is the function of this protein?
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.  Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Increases IL-8 transcription.  Involved in IL-18-mediated signaling pathway.  Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes.  Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity).  MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
What are the official names of this protein?
Myeloid differentiation primary response protein MyD88.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: EX7S_KLEP7
Sequence: MPKKNEAPASFETALGELEQIVNRLESGDLPLEEALSEFERGVQLARQGQSQLQKAEQRVQILLADSEDSPTTPFTPDAE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSD_BRUA1
Sequence: MSLTDTIRNTFVPIHREGYPFIAGFFVVSLILGWLWDPLFWIGMVLTVWCIYFYRDPERVTPMDDDLVISPADGKVSFVGLAVPPAELDLGYEPMTRVSVFMNVFSVHINRSPVRGKIDKVVHRPGKFLNAELDKASTENERNSVLIESPHGKIGVVQIAGLVARRIVCWSNQDDELSVGERFGLIRFGSRVDVYLPSDATVRVAVGQTAIAGETVLADYGTERGEPVVRIA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: ISPE_TOLAT
Sequence: MSTPENMAWPAPAKLNLFLHVNGRRSDGYHELQTLFIFLDHCDWLRFHINNSDLVDIKPALADVPPEQNLIYRAAMLLKQYSTQPLGVMVELDKRLPMGGGIGGGSSDAATTLVALNYLWKINLPVDELAELGRQLGADVPVFVRGHAAFAEGVGEKLLPVEVTQKWYLVLVPECHVSTAEIFRHKDLKRDTPKQNWRELQQGNWHNDCEPLVKKNYPEVEKALRWLIEYAPSRMTGTGACVFAEFKHEHEAREVLALIPTWLRGFVARGENLSPLHVVLQQVYA
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: CYC22_RHOCE
Sequence: EDGDPAKGEAVFKKCMACHRVGPDAKNLVGPALTGVIDRQAGTAPGFNYSAINHAAGEAGLHWTPENIIAYLPDPNAFLRKFLADAGHAEQAKGSTKMVFKLPDEQERKDVVAYLKQFSPQ
What is the function of this protein?
Cytochrome c2 is found mainly in purple, non-sulfur, photosynthetic bacteria where it functions as the electron donor to the oxidized bacteriochlorophyll in the photophosphorylation pathway.  However, it may also have a role in the respiratory chain and is found in some non-photosynthetic bacteria.
What are the official names of this protein?
Cytochrome c2 iso-2, Cytochrome c552.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
Protein: RL28_BACC4
Sequence: MARVCAITGRKARSGNSRSHAMNATKRKWGANLQKVRVRIDGKVQRVYVSARALKSGKIERV
What are the official names of this protein?
50S ribosomal protein L28.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL28 family.
Protein: COAX_PELUB
Sequence: MIIVGDIGNTETKICLVNSKNIIIKRVILLTKKINHSSLNKSLLGLNLKNKSINKCLFCSVVPKKFNAVKIFFKKVYKIKCHELKKLNLNKLIKIKVNYKQIGSDRLANAISIINNKDNFIILDFGTATTFDVLIKNTYHGGVIAPGVKLSLDTLTDKASQIPKINLKKTNRVIGLNTISAVRAGFFWGYEGLIDNIVNLIKKETKMSFKIIITGGFSGLFKNSIKTKVTLNKDITIKGLIRATTLIK
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_STRPS
Sequence: MAREFSLEKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWNNHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVSTLHDRLQANAHPIQLPIGSEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPAEYLDQAQEYREKLIEAVAETDEELMMKYLEGEEITNEELKAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVIDYLPSPLDIPAIKGINPDTDAEETRPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLQSGSYVLNTSKGKRERIGRILQMHANSRQEIDTVYSGDIAAAVGLKDTTTGDSLTDEKSKIILESINVPEPVIQLMVEPKSKADQDKMGIALQKLAEEDPTFRVETNVETGETVISGMGELHLDVLVDRMRREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLVESMANGVLAGYPMVDVKAKLYDGSYHDVDSSETAFKIAASLSLKEAAKSAQPAILEPMMLVTITVPEENLGDVMGHVTARRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSASQGRGTFMMVFDHYEDVPKSVQEEIIKKNKGED
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y056_NPVAC
Sequence: MLRSIMRRFKSTNNLSKKPSDYYVVLCPKCYFVTSAEVSVAEYIEMHKNFNTKFADRCPNDFIVTNSKSWNNHENCSALFYPLC
What are the official names of this protein?
Uncharacterized 9.9 kDa protein in LEF8-FP intergenic region.
Protein: GATZ_ECOHS
Sequence: MKTLIARHKAGEHIGICSVCSAHPLVIEAALAFDRNSTRKVLIEATSNQVNQFGGYTGMTPADFREFVFTIADKVGFARERIILGGDHLGPNCWQQENADAAMEKSVELVKEYVRAGFSKIHLDASMSCAGDPIPLAPETVAERAAVLCFAAESVATDCQREQLSYVIGTEVPVPGGEASAIQSVHITHVEDAANTLRTHQKAFIARGLTEALTRVIAIVVQPGVEFDHSNIIHYQPQEAQPLAQWIENTRMVYEAHSTDYQTRTAYWELVRDHFAILKVGPALTFALREAIFALAQIEQELIAPENRSGCLAVIEEVMLDEPQYWKKYYRTGFNDSLLDIRYSLSDRIRYYWPHSRIKNSVDTMMVNLEGVDIPLGMISQYLPKQFERIQSGELSAIPHQLIMDKIYDVLRAYRYGCAE
What is the function of this protein?
Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit.  Could have a chaperone-like function for the proper and stable folding of GatY.  When expressed alone, GatZ does not show any aldolase activity.  Is involved in the catabolism of galactitol.
What are the official names of this protein?
D-tagatose-1,6-bisphosphate aldolase subunit GatZ.
What is the protein family that this protein belongs to?
Belongs to the GatZ/KbaZ family. GatZ subfamily.
Protein: METE_BURPS
Sequence: MTTAHILGFPRIGAQRELKFALERYWRDGASADAERALVDTGRALRAEHWRIERDAGLDCVTVGDFAWYDHVLTTLAHVGGLPRRFGFDARALTLADYFAAARGNAAQPAMEMTKWFDTNYHYLVPEYSPATTFGPGVEWLFDEVREARALGYRAKAALVGPLTLLWLGKARDGLVERLALLPRLVPAYRALLARLREAGVDWVQIEEPIFSLDLPDAWRDAARPTYEALAPGAPKLLVATYFDDASEHAALLKALPVAGLHIDLVRADAQLDAFVADYPADKVLSCGIVDGRNVWRNDLDRSLARLAPVRDALGERLWVATSCSLLHVPVDLAHEPRLDEELKTWLAFAAQKTREVAALRDALVKGRAAVAAEFDDAAAAAAARRTSARIHNPLVKRRVAALTDADARRASAYSVRAAAQRARFGLPLLPTTTIGSFPQTPEIRRARAAFKQGVLDHLGYLEAMREQVRIAIDKQLAYGLDVLVHGEAERNDMVEYFGELLWGFAITSNGWVQSYGSRCVKPPLVYGDVYLPEPMTVGWASYAQSLSAKPVKGMLTGPVTMLQWSFVRDDQPRATTALQIALALRQETLDLEKAGIGMIQIDEPALREGLPLKARERAAYLDWAVRAFGIAASGVADDTQIHTHMCYSEFGDILPSIAALDADVISIETTRSNMELLDAFETFDYPNEIGPGVYDIHSPRVPDADEIERLILLALERIPAQRLWVNPDCGLKTREWRQVDAALAAMVDAAKRVRQKVEEEAPA
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: F169A_MOUSE
Sequence: MAFPVDLLDNCTHEELENSSEDYLSSLRCGDPEHPECFSSLNITIPVSLSNVGFVPLYGGNQTQKILALFAPEDSLTAVALYLVGQWWAIDDIVKTSEPSREGLKQVSTLGERVVLYVLNRIIYRKQEMERNEIPFLCHSSTDYAKILWKKGEAVGFYSVKPTGSLCASFLTQNYQLPVLDTMFIRKKYRGKDLGLHMLEDFVDSFTEDALGLRYPLSSLMYTASKQYFEKYPGDHELLWEVEGVGHWHQRVPVTRALQREAIKATDVSQYEATRPVSGEYGLAAVPEHEPGLDDTQSSELQIHSLKDAFASTSEGPEKTPVSTRTRSSHLKRPKIGKHFQDSEFSSSQGEDENVAKTSPTASVNKIEYAARTSESSEEFLEEEPEQGVIDFEDESGDKDAQPALETQPRLQKQDGDKDSALEPVNGEVMDAALKPSLTTEDEDSTSEGLEEDLKVPPFNSSGEPGNPVPLVAESSKVPEATLAKTSPDTDSEMLIDQSPSDDKGHTEENLSPVSKKKTLLGSSDNVATVSNIEKSDGNFPNSVVPEFPEEPVSQNLSPNTTSSVEDQGEEGAPEAQEPSATQSSLIEVELEDAPFPQNAGQKSQSEEQSEASSEHLEQFTQSAEKAVDSSSEEIEVEVPVVDRRNLRRKAKGHKGPGKKKAKLT
What are the official names of this protein?
Soluble lamin-associated protein of 75 kDa, SLAP75, Protein FAM169A.
What is the protein family that this protein belongs to?
Belongs to the FAM169 family.
What are the subcellular locations of this protein?
Nucleus envelope. Nucleus inner membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Enriched at the nuclear lamina.
Protein: KATG_NATPD
Sequence: MSIDYKKLWPEALDFESLDQNAQHVDPKDEDFDYAEAFQELDLEEVKQDIESVMTDSQEWWPADYGHYGPLFIRMAWHSAGTYRTTDGRGGASGGYQRLPPVDSWPDNANLDKARRVLWPVKQKYGQNLSWADLIVLAGNVALESMGFETFGFAGGREDDFAPDESVDWGPEEEMEASDRYDEAGELPEPLGATVMGLIYVNPEGPDGEPDLEGSAANIRESFGRMAMNDEETVALIAGGHTFGKVHGADDPDEHVGGPPADAPIDLQGLGWENDFGEGKGPDTITSGIEGPWNTTPTQWDMSYIDNLLDYEWWPEKGPGGAWQWTTESGELDAAAPSVDGSSEKEDVMMLTTDVALKRDPDYREVLERFQENPDEFQEAFAKAWYKLIHRDMGPPERFLGPEVPEETLIWQDPLPDADYDSIGDEEVAELKEALLDSELSVAQLVKTAWASASTYRDSDKRGGANGARIRLEPQRSWEVNEPAALADALETYEAIQEEFNSARSDAVRVSLADLIVLGGNAAVEQAAADAGYDVTVPFEPGRTDATPEQTDVESFEALKPKADGFRNYLSDEAERKPEELLVDKADLLNLTPPEMTVLVGGMRALGATYQDTDRGVFTDEPGTLTNDFFVNILDMDYEWEPVSEDREVFELRDRETGEVEWEGTRFDLIFGSDSRLRAISEVYGADDGEAEFVEDFVDTWSKVMKLDRFDLE
What is the function of this protein?
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: RLMG_ECOLI
Sequence: MSHLDNGFRSLTLQRFPATDDVNPLQAWEAADEYLLQQLDDTEIRGPVLILNDAFGALSCALAEHKPYSIGDSYISELATRENLRLNGIDESSVKFLDSTADYPQQPGVVLIKVPKTLALLEQQLRALRKVVTSDTRIIAGAKARDIHTSTLELFEKVLGPTTTTLAWKKARLINCTFNEPQLADAPQTVSWKLEGTDWTIHNHANVFSRTGLDIGARFFMQHLPENLEGEIVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNMPEALDRCEFMINNALSGVEPFRFNAVLCNPPFHQQHALTDNVAWEMFHHARRCLKINGELYIVANRHLDYFHKLKKIFGNCTTIATNNKFVVLKAVKLGRRR
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_SODGM
Sequence: MQKLAELYRGKAKTVYTTEDPDLLILTFRNDTSALDGQRIEQFDRKGMINNNFNYFIMTKLAEAGIPTQIVRLLSDNEMLVKKLAMVPVECVVRNRAAGSLVKRLGVEEGLVLDPPLFDLFLKNDAMHDPMINESYCTTFGWVSEPHLARMKQLTYQANDVLSKIFDDAGLILVDFKLEFGLFNGEIVLGDEFSPDGSRLWDKTTLDKMDKDRFRQNLGGVIEAYEEVAKRIGVTLD
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: FDL43_ARATH
Sequence: MHPETEQACLVPSSKKTKLCSENFEDKFSSLLESVVSIILSQLPTAEAVSTSVLSKSWKNIWTNITDLHFDDTKQRDPSDSRFTDFVERVVGDIGSPHISSFYLCSVNTFDETLLFSWLSKVLKRNLQRLVVTCNDLEIISFSSLFPSFVSLVELRLRTKSILDISAPAILPNLKFLSLEDARIFNMSSVSKNLVLNFPVLETFEASYCRCFRTDTVIIDSPLLRIFEMFKCTSEHVPNPSQVCKIRVLASKLEKITFCGDEPRKIHLSFPPSLPDAYLALSRSEWPKTFLRSFTCVTSLALVLSKDFHVMAVPKFSQLVYLHLIYDMTQHFRLMQFLKSAPILEMLSIRDLTSPRSTPTAKSLKELRSVESPDCVTTMLKVLQIRNFKPNRLQISVLRYVLDNAEILGSVILSSPNPITEEEKARILAFPKASPHASVLFE
What are the official names of this protein?
F-box/FBD/LRR-repeat protein At3g14710.
Protein: TREX1_HUMAN
Sequence: MGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE
What is the function of this protein?
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini (PubMed:10391904, PubMed:10393201, PubMed:17293595).  Prevents cell-intrinsic initiation of autoimmunity (PubMed:10391904, PubMed:10393201, PubMed:17293595).  Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements (PubMed:10391904, PubMed:10393201, PubMed:17293595).  Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation (PubMed:33476576).  Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation (PubMed:33476576).  Unless degraded, these DNA fragments accumulate in the cytosol and activate the cGAS-STING innate immune signaling, leading to the production of type I interferon (PubMed:33476576).  Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates (PubMed:18045533).  Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light (PubMed:23993650).  During GZMA-mediated cell death, contributes to DNA damage in concert with NME1 (PubMed:16818237).  NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (PubMed:16818237).
What are the official names of this protein?
Three-prime repair exonuclease 1, 3'-5' exonuclease TREX1, Deoxyribonuclease III, DNase III.
What is the protein family that this protein belongs to?
Belongs to the exonuclease superfamily. TREX family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the cytoplasm through the C-terminal region (By similarity). Localization to the endoplasmic reticulum membrane is required to direct TREX1 to ruptured micronuclei (PubMed:33476576). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci (PubMed:16818237). Translocation to the nucleus also occurs during GZMA-mediated cell death (PubMed:16818237).
Protein: NUOCD_CROS8
Sequence: MVNNMTDLTAQDAVLPVWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWVKREQLLEVGEFLRKLPKPYVMLYDLHGMDERLRTHRNGLPAADFSVFYHLLSIDRNRDIMLKVALSENDLNVPTFTRLFPNANWYERETWEMFGITFTGHPNLRRIMMPPTWEGHPLRKDYPARATEFDPFTLTKQKEELEMEALTFKPEEWGMKRGNDTEDFMFLNLGPNHPSAHGAFRIILQLDGEEIVDCVPDIGYHHRGAEKMGERQSWHSYIPYTDRVEYLGGCVNEMPYVLAVEKLAGIQVPERVEVIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFRIGGVAHDLPRGWDRLLKEFLEWMPKRLDSYVKAALKNTILKGRSQGVAAYDAKEALAWGTTGAGLRATGIDFDVRKARPYSGYQNFEFEVPVGGGISDCYTRVMLKVEEVRQSLRILEQCLKNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRVRTPSFPHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: LOX14_SOLTU
Sequence: MLGQIVGGLIGGHHDSKKVKGTVVMMKKNALDFTDLAGSLTDKIFEALGQKVSFQLISSVQSDPANGLQGKHSNPAYLENFLFTLTPLAAGETAFGVTFDWNEEFGVPGAFIIKNTHINEFFLKSLTLEDVPNHGKVHFVCNSWVYPSFRYKSDRIFFANQPYLPSETPELLRKYRENELLTLRGDGTGKREAWDRIYDYDVYNDLGNPDQGKENVRTTLGGSADYPYPRRGRTGRPPTRTDPKSESRIPLILSLDIYVPRDERFGHLKMSDFLTYALKSIVQFILPELHALFDGTPNEFDSFEDVLRLYEGGIRLPQGPLFKALTDAIPLEMIRELLRTDGEGILRFPTPLVIKDSKTAWRTDEEFAREMLAGVNPIIISRLQEFPPKSKLDPEAYGNQNSTITAEHIEDKLDGLTVDEAMNNNKLFILNHHDVLIPYLRRINTTTTKTYASRTLLFLQDNGSLKPLAIELSLPHPDGDQFGVTSKVYTPSDQGVESSIWQLAKAYVAVNDSGVHQLISHWLNTHAVIEPFVIATNRQLSVLHPIHKLLYPHFRDTMNINAMARQILINAGGVLESTVFPSKFAMEMSAVVYKDWVFPDQALPADLVKRGVAVEDSSSPHGVRLLIEDYPYAVDGLEIWSAIKSWVTDYCSFYYGSDEEILKDNELQAWWKELREVGHGDKKNEPWWPEMETPQELIDSCTTIIWIASALHAAVNFGQYPYAGYLPNRPTVSRRFMPEPGTPEYEELKKNPDKAFLKTITAQLQTLLGVSLIEILSRHTTDEIYLGQRESPEWTKDKEPLAAFDKFGKKLTDIEKQIIQRNGDNILINRSGPVNAPYTLLFPTSEGGLTGKGIPNSVSI
What is the function of this protein?
Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding.  Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.
What are the official names of this protein?
Probable linoleate 9S-lipoxygenase 4, Root lipoxygenase.
What is the protein family that this protein belongs to?
Belongs to the lipoxygenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATA_SPHAL
Sequence: MTELTNLTVAQIRDGHRAGDFSAVEVAEAFNANVAAAKALNAFIVETPDLAIEAAKAADADRAAGTLKPLSGVPIGMKDLFCTNGVQTTAASHMLEGFVPRYESTVSQKLWDAGAGMLGKLNLDQFAMGSSNETSYFGNVISPWRRNDGGNAALAPGGSSGGSSAAIAARLCPAATGTDTGGSIRQPAAFTGISGIKPTYGRCSRWGIVAFASSLDQAGPMARTVRDCAIMLENMAGFDPKDATSLDLPVPNWEAALSSDLRGKTVGIPREYRLEGIDPDIDAMWDAGIAMLKDAEAAVVEISLPHTKYALPAYYIIAPAEASSNLARYDGVRYGLRDLPQGAGLQDMYAATRAEGFGAEVKRRIMIGTYVLSAGFYDAYYTQAQKVRTLIARDFEAAFGSCDVILAPTAPSAAFGLGEKMADPLAMYLNDVFAVPASLAGLPAMSVPAALNREGLPLGLQIIGKPFDEQGVLNAGLAIEERAGFTARAEKWW
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: LENEP_HUMAN
Sequence: MQPRTQPLAQTLPFFLGGAPRDTGLRVPVIKMGTGWEGFQRTLKEVAYILLCCWCIKELLD
What is the function of this protein?
May play a role in lens epithelial cell differentiation.
What are the official names of this protein?
Lens epithelial cell protein LEP503.