PharMolix/UniProtQA huggingface dataset:
Protein: ISPG_ECO7I
Sequence: MHNQAPIQRRKSTRIYVGNVPIGDGAPIAVQSMTNTRTTDVEATVNQIKALERVGADIVRVSVPTMDAAEAFKLIKQQVNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRMVVDCARDKNIPIRIGVNAGSLEKDLQEKYGEPTPQALLESAMRHVDHLDRLNFDQFKVSVKASDVFLAVESYRLLAKQIDQPLHLGITEAGGARSGAVKSAIGLGLLLSEGIGDTLRVSLAADPVEEIKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDVSIIGCVVNGPGEALVSTLGVTGGNKKSGLYEDGVRKDRLDNNDMIDQLEARIRAKASQLDEARRIDVQQVEK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: MC163_MCV1
Sequence: MGPRAQRARSTLRKLRRALCGRQDSPARARTPENRHFARKCARTCEHGYAHTHTCEDTPAKEHGHLGEHECLRGHGHAHAYEERCENKHKHLHAHEHTHERHGRAPRRLALTAPLPLLLLPLLLPPMILLFFLSPADAKPVLERQVFWNHSEPRASFLTPPHGPGAPPGGPFLTAVGGDGTLYLIPSNSSNPPVCVEIPLPYGPGHENVITLLLVDGGPRTPDALTVAACLEVGVSLLTTNATEPTNASNSSPRLTGSCEKLRTWALGNPPFTRVCGTGGGTPRCWALSTNGSIHDLGLDGVGYSPPQHNGTRPLLCTNTSEPHLHSCEHTAWNGDHDPQRCTRTPLDKHGQSWSPQCHKSTAPNQLGTRPPLLITKMSDENGTDYVYFLIGGSGDDYPPLLARVCEDDCWLSGHWTPRLQTVLQTNVSCANASALLKSTSGNGGPIVLLVEGEGGNGSICTYSGLDTGKHFAHTPQLGETGPRDPLVGACGHNGDVPESLAKKAREHPDLKQTLTPSGGPVALPGLDPRHVTALGTGPGLLFLGTNQSNVFLLRMNDNGRPNGSLTLFWNGTGNGNGRAGPRGPVLGLQHSSGGGAGAAGLLAVLFGDGVTVLRTEGAL
What is the function of this protein?
Plays a role in the inhibition of host apoptosis.  Prevents host TNF-alpha-induced mitochondrial membrane permeabilization and reduces caspase-3/CASP3 and PARP1 cleavage induced by the intrinsic apoptotic pathway.
What are the official names of this protein?
Apoptosis regulator MC163R.
What are the subcellular locations of this protein?
Host mitochondrion. Host membrane; Single-pass membrane protein.
Protein: RNP2_METM6
Sequence: MLKTLPPTLREKKRYVALEIIFEEELFQKDVISIVRNALMNYSGVLGCSKANPWLIDYNHPYGILRISREEVDNLRSSLSLANEHRKKPINIHIIGISNSVKHIREKFLHVPHEPYYKVIQKLKKKGPKK
What is the function of this protein?
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
What are the official names of this protein?
Ribonuclease P protein component 2, RNase P component 2, Pop5.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ILVC_PROMP
Sequence: MTQLFYDTDADLSLLKNKTIAIIGYGSQGHAHALNLKDSGMDVIVGLYKGSNSESKAINDGLKVFTVSEACEKADWIMILLPDEFQKDVYIKEIEPNLKEGKILSFAHGFNIRFELIKPPNFVDVVMIAPKGPGHTVRWEYQNGQGVPALFAVEQDYSGNARSLAMSYAKGIGGTRAGILETNFKEETETDLFGEQAVLCGGLSELVKSGFETLVEAGYQPELAYFECLHEVKLIVDLMVKGGLSQMRDSISNTAEYGDYVSGKRLINNETKKEMQKILKDIQDGTFAKNFVDECDNNKPLMTKLREENSKHEIEKVGKGLRAMFSWLK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: LMOD1_RAT
Sequence: MSKVAKYRRQVSEDPDIDSLLSTLSPEEMEELEKELDVVDPDGSIPVGLRQRNQTDKQPSGSFNREAMLNFCEKESKKIIQREMSVDESKQVGRKTDAKNGEDKGSNASRKALGPRQDSDVGKEPKKGVLKKSFSRDREEADSRGSEKPKEEKVIRGIDKGRVRAAVDRKEAGKDGREERAAATTKKEEEKTGSVRNAGLSRDKDKKREEVKEPSKKEEVKLTAENRSTVGRQEDGKQKESREDRDKKPEVKGIGCGSRDSRKEDEKVKKEETQPDKGVREEGKTREKQPPSGPSKPSDGQARAEEEAAPSIFDEPLEKVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTVVKVFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQEQKQAQEASGEKKDRLEVPKVGALPKGSPKPSPQPSPKSAPKNSPKKAGVPAAPPPPPPPLAPPLIMENLKNSLSPATQRKMGDKVLPAQEKNSRDQLLAAIRSSNLKQLKKVEVPKLLQ
What is the function of this protein?
Required for proper contractility of visceral smooth muscle cells (By similarity).  Mediates nucleation of actin filaments (By similarity).
What are the official names of this protein?
Leiomodin-1, Smooth muscle leiomodin, SM-Lmod.
What are the subcellular locations of this protein?
Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton. Note=Colocalizes with actin filaments in sarcomeres.
Protein: T178B_XENTR
Sequence: MRLLAGAGLCLALAALALLAVALSTDHWYETDARRHRDRCRKPGGKRNDPGYMYTPGQHLPLRGEPPSSRIRSPRGGEPGGVRMISRAEDLGVRGLRERPTGARDLPLSRPYLATDPHCSRRFNSTVSGLWRKCHRDGFDKDTEELILKGIVERCTSVRYYYTSSSLPPNLSVNVTKTIRQDEWHALHLRRMTAGFIGMAVSIILFGWMVGVLGCCKQHDLMQYVAGLLFLMGGTCCIISLCTCVAGINFELSRYPRSIYSLPEEISHGYGWSMFCAWGGLGLTLLSGFLCTLAPSLSASQSAVHKPRQENGAV
What are the official names of this protein?
Transmembrane protein 178B.
What is the protein family that this protein belongs to?
Belongs to the TMEM178 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL21_DESVV
Sequence: MYAIIETGGKQFRVEEGSKIFVEKLASEAGSEIVIDKVLMLGGGDVKVGAPYVENAKVTAEVVEHGRGEKVVIFKKWRRNDSRKKQGHRQDFTALKIKAITA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.
Protein: DCN1_CANAL
Sequence: MSSKTQLRQQFCELTGTSNTTATKYLESVRYDLARAIDNYYNKHPNKAQVTKKPVKVKIDDRLIQIFDKYKDSEDPNKIDIEGTLTYLGDLGISPDQIESLSLALLLKSPKTGVFTRENFLHIWQYYQCFDIGAMSEFITRFNKDLVNNIGGFKDISTVSDDENKSVPLKFQDLYNFTFKFSLETESQKFLDLDTAIEYWKLLLPIITETYSKDNKLDEEFKNHVNERVEQWFKFLTDTEYMTKKSISYDSWSMFYLFFKEIVLIDPIKFKDYDEMAAWPSVVDEFLEYLHDFELL
What is the function of this protein?
May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes.  Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).
What are the official names of this protein?
Defective in cullin neddylation protein 1.
Protein: PDLI3_CHICK
Sequence: MPQNVILPGPAPWGFRLSGGIDFNQPLIITRITPGSKASTANLCPGDIIVAINGLSTENMTHNDAQERIKAAAHQLSLRIERAETKLWSPQVSEDGKANPYKINLEAEPQEFKPIGTAHNRRAQPFVAAANIDDKRQVVSSSYNSPIGLYSSGNIQDALHGQLRSLIPNASQNDPAPAAVPQSDVYRMLHSNQEEPSQPRQSGSFKVLQNLVSEEDGRPVGTRSVKAPVTKIPTGLPGAQKVPQCDKCGSGILGTVVKARDKYRHPECFVCSDCNLNLKQKGYFFVEGQLYCEAHARARMRPPEGYEAVTVYPKC
What is the function of this protein?
May play a role in the organization of actin filament arrays within muscle cells.
What are the official names of this protein?
PDZ and LIM domain protein 3, Alpha-actinin-associated LIM protein.
What are the subcellular locations of this protein?
Note=Isoform 1 colocalizes with alpha-actinin along actin stress fibers and lammellipodia of spreading fibroblasts. Isoform 2 colocalizes with alpha-actinin at the Z-lines of myotubes. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note=Isoform 1 colocalizes with alpha- actinin along actin stress fibers and lammellipodia of spreading fibroblasts. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Isoform 2 colocalizes with alpha- actinin at the Z-lines of myotubes.
Protein: RLME_BURCM
Sequence: MAKNRFNQNWLHDHINDPYVKMAQREGYRARAAYKLKEIDEQDKLIRPGQVIVDLGATPGSWSQYARNKLAQGKKRDTQREGGIDGTIIALDLLPMEPIADVHFIQGDFREDDVLRQLEDVLEGRAVDLVISDMAPNLSGVASADAARIEHLCDLALEFAQNHLKPDGALLVKCFHGSGYSQIVEKFKQQFKVVAPRKPKASRDKSSETFILGRQLKQPR
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS3_ALKEH
Sequence: MFKDLEKARPGTRRDLPAVLAALPWNAQGLLPAIAQQHDSGEVLMMAWMNREALEETLRTGRVCYYSRSRRSLWRKGESSGQVQRLVELRLDCDGDTLLLRVDQTGPACHTGRRSCFYNRLDGDGLEVIAAPEIDPETLYHR
What is the function of this protein?
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
What are the official names of this protein?
Phosphoribosyl-AMP cyclohydrolase, PRA-CH.
What is the protein family that this protein belongs to?
Belongs to the PRA-CH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IML2_SCLS1
Sequence: MSRWFKSAVKATPAMVAESEEQHLRDVEAAMLKLLNDDIEEADKLLKKHDSSYHHLGRGISGFLSAMMGVEKDLLKEAAVILQDAENKSWDDMKKAQKDSTAFQSNIYPQGTEYLLCYSVAQLTSAITAVLSGSITEAVKGFYKLRKAYLTLDGILEVENKYLEKIAHSSTTSLSSRTPSHKSSMAALTVDEIAHRTADLSVGDLDEKMLDPNNPYPNISRPPSPPSVTNPYDIDPELAARVFTNRTDIFIHSGVRLCCGLLLLVFSMIENPIFNKILYIVGFKGDRERGTRLLWQATRYQNFNSAIAALALLGYYNGLVGFCDILPTDDAADDNPTGYPKNKCQALLVDMQSRYPHSKLWKLEEARMLSYKQDLKGALVILEENSKSKMKQITMINTFEMALTTLFIHEYEKSATAWINCSEQSAWSPTLYFYIAGISYVELYRNTRLSDPAAAEVHKKKAIEFILKAPPLAGKQKVMAKQLPFDIYIVSKVGKWEQRAKAWGVDLVDAIGPSPFVEMIYFWNGVKKSGTVELEKCLDLLKKERMTCPEKCNEDEEDVAIHLLLRGSCCSWREKDLPPGGDSTSGEKMSEKKLLEYRREKLMDCEEKLLKLHSWPQTYVFETRMSFKISTSLLTVKRHKGLMGF
What is the function of this protein?
Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins.  Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
What are the official names of this protein?
Inclusion body clearance protein iml2.
What is the protein family that this protein belongs to?
Belongs to the IML2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized exclusively in cytoplasmic inclusion bodies under protein folding stress conditions.
Protein: TRM82_KLULA
Sequence: MLHPFQSVLLNRDGSLLFCVVKNEIKAFKVEGNGYVLRGEWVDDLDNTPLIKEKVLKEQARQLIENASKKLKTNDGEPVAQPKKQAKVPKPGPGAPPVYQYIRNLALSRDGKLLLACTDSDKAAVIFNIDLDDKDNIFKLIKRQPYPKRPNAITTSVDDKDLILADKFGDVYSMPIQNDVITSINAEKAPILGHVSMLTDVNMLTDSEGKQYIVTADRDEHIRISHYPQSFIVDKWLFGHEEFVSTICIPEWSDKLLFSAGGDKFVFSWNWKTGALLFKFDYTDLIQKYLTSDHLAPERFQNEKGDVIEYSVAKIVTLKDVPYIAFFVEATKVLFVLKVDEKSGALSLHQTLEFDEKIVSLTSALDVNTLCISLDNRDNQDCDLVKLLLLEGDVFIEQKDTNSQLMNTIRSTLKSDLIANVEAGDVYPLYHNASLRKHGEHFS
What is the function of this protein?
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.  In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82, Transfer RNA methyltransferase 82.
What is the protein family that this protein belongs to?
Belongs to the WD repeat TRM82 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CP3A5_PAPSP
Sequence: MDLIPDLAVETWLLLAVTLV
What is the function of this protein?
6-beta-testosterone hydroxylase.
What are the official names of this protein?
Cytochrome P450 3A5, 6-beta-testosterone hydroxylase, CYPIIIA5, Cytochrome P450 FA.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: CMOA_HELPY
Sequence: MKDTLFNESLNKRFCFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIAQNLKENIYPKSLPKPLIYDLGCSTGNFFIALNRQIQQEIELVGIDNSMPMLKKAQEKLKDFNNARFECMDFLEVEFKEASAFSLLFVLQFVRPMQREVLLKKIYNSLALNGVLLVGEKIMSEDRILDKQMIELYYLYKQNQGYSHNEIAFKREALENVLVPYSLKENVALLESVGFKHVEALFKWVNFTLLVARKT
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: FINC_HORSE
Sequence: MLRGPGPGLLLLVVLSLGTAVPSSGASKRKRQDQQIIQPQSPVAVGQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEPEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHASLQTTSTGSGPFTDVRTAIYQPQPHPQPAPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDSAVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRVGDQWDKQHDMGHMMRCTCVGNGRGEWTCVAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQCQDSETRTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPGTTGPVQVIITETPSQPNSHPIQWNAPEPSHISKYILRWKPKNAPGRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQHYGHKEVTRFDFTTTSTSPAVTSNTVTGETTPFSPVVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELTLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGVPRADKVPPPRDLQFVEVTDVKITIMWTPPESAVTGYRVDVLPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYHFKIFAVNHGRESKPLTGEQTTKLDAPTNLRFINETESTVIVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPSASQYPLRSLQPGSEYTVTLVAVKGNQQSPKATGVFTTLQSPGSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTISVLRDGQERDAPIVKKVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTSGQQGYSLEEVVHADQSSCTFENLSPGLEYNVSVYTVKDDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNVGPDTMRVTWAPPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHTGGRPREDRVPPSRNSITLTNLNPGTEYVVSIVALNGREESPPLVGQQSTVSDVPRDLEVIATTPTSILISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISIDYRTEIDKPSQMQVTDVQDNSISVRWLPSSSPVTGYRVTTTPKNGPGQSKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNQNGESQPLVQTAVTNIDRPRGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTELKFTQVTPTSLTAQWTAPNVQLTGYRVRVTPKEKTGPMKEINLAPDSTSVVVSGLMVATKYEVSVYALKDTLTSRPAQGIVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQPPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVIIDASTAIDAPSNLHFLATTPNSLLISWQPPRARITGYIIKYEKPGSPPREVVPRPHPGVTEATITGLEPGTEYTIQVIAIKNNQKSEPLIGRRKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFITNPGYDNGNGIQLPGTSGQQPSVGQQMIFEEHGFRRTTPPTTATPVRHRPRPYPPNVNEEIQIGHVPRGDVDQHLYPHVLGLNPNTSTGQEALSQTTISWTPFQESSEYIISCHPVGIDEEPLQFRVPGTSASATLTGLTRGATYNIIVEALKDQKRHKVREEVVTVGNSVDQGLGQPTADSCFDPYTVSHYAIGEEWERLSESGFKLSCQCLGFGSGHFRCDSSKWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGAEPGHEGSTGHSYNQYSQRYQQRTNTNVNCPIECFMPLDVQADRDDSRE
What is the function of this protein?
Probably involved in matrix organization of cartilage.
What are the official names of this protein?
Fibronectin, FN.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: GLMU_SALTI
Sequence: MLNSAMSVVILAAGKGTRMYSDIPKVLHTLAGKPMVQHVIDAATKLGAAQVHLVYGHGGELLKQTLKDDKLNWVLQAEQLGTGHAMQQAAPFFSDDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPSGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADLKRWLSKLTNNNAQGEYYITDIIALAYQEGREIAAVHPARISETDGVNNRLQLSRLERIYQAEQAEKLLLSGVMLRDPARFDLRGTLYCGMDVEIDANVIIEGYVTLGHRVKIGAGCIIKNSVIGDDCEISPYSVVEDAHLEAACTIGPFARLRPGAELLAGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTVIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVADNELVLSRVPQVHKQGWQRPVKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE1_UREP2
Sequence: MFKISRKNYSDLYGITTGDSVRLGDTNLWVKVEKDLTTYGEESVFGGGKTLREGMGMNSTMKLDDKLGNAEVMDLVITNALIVDYTGIYKADIGIKNGKIAAIGKSGNPHLTDNVDMIVGISTEISAGEGKIYTAGGLDTHVHWLEPEIVPVALDGGITTVIAGGTGMNDGTKATTVSPGKFWVKSALQAADGLSINAGFLAKGQGMEDPIFEQIAAGACGLKIHEDWGATGNAIDLALTVADKTDVAVAIHTDTLNEAGFVEHTIAAMKGRTIHAYHTEGAGGGHAPDILETVKYAHILPASTNPTIPYTVNTIAEHLDMLMVCHHLNPKVPEDVAFADSRIRSQTIAAEDLLHDMGAISIMSSDTLAMGRIGEVATRTWQMAHKMKAQFGSLKGDSEFSDNNRVKRYISKYTINPAIAHGVDSYIGSLEVGKLADIVAWEPKFFGAKPYYVVKMGVIARCVAGDPNASIPTCEPVIMRDQFGTYGRLLTNTSVSFVSKIGLENGIKEEYKLEKELLPVKNCRSVNKKSMKWNSATPNLEVDPQTFDAAVDFNDLENWLEQSASELAKKLKKTSSGKYILDAEPLTEAPLAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRD_XYLFA
Sequence: MYSLFRPLLFTCDTERAHDISLCTLDIAYHSGALPLLTRHPRPLPTTAFGLNFPNPVGLAAGLDKNGTHIDALFALGFGFIEIGTTTPRPQPGNPKPRLFRLTQQQAVINRMGFNNLGVDALVRNVAGARQRNGPLGINIGKNKDTPNEQASNDYRYCLERVYALADYVTINLSSPNTAGLRALQEEQTLRRLIGELREAQETLAAKHGRHVPMLIKMAPDLSDSDIDAAARVLNEMSVDGVIATNTTVTRPLLRQHRLASETGGLSGAPLLGQSTLVLRRLRTHLPETIALIGVGGICCGADAVAKMAAGANLVQCYTGLIFKGPQLVGECVEAIRRRREASSSGRASTQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: S7A13_RAT
Sequence: MAMDIEKKIYLKRQLGYFWGTNFLIINIIGAGIFVSPKGVLQYSSMNVGVSLCVWVFCAVLSMTSTLCAAEIGITFPYTVAHYYFLKRCFGPFVAFLRLWTSLFTGPGVLASQALLLAEYGIQPFYPSCSAPAVPKKCLALAMLWIVGILNSRGVKELSWLQTVSMVLKMGILSFISLSGLFLLVTGRKENVRRLQNAFDAEFPEVSRLIEAIFQGYFAFSGGGSFTYVAGELKEPSKTIPRCIFTALPLVTVVYLLANLSYLTVLSPQELLSSDAVALTWTDRVIPQLTWSVPFAISASLFSNLVTSVFETSRTSYIASRNGQLPLLCSTLNVHSSPFIAVLLDVSMGSIAIVLTNLIELINYLFFVFSIWTVLSVIGILKLRYQEPNLHRPYKVFSPFLFITAAISLSMVLIPLIKSPKMQYIYVFLFFLGGLLFYVPLIHFKLKLIWFQKLTCYLQLLFNICIPDVSDEHVAEEES
What is the function of this protein?
Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner.
What are the official names of this protein?
Solute carrier family 7 member 13, Sodium-independent aspartate/glutamate transporter 1.
What is the protein family that this protein belongs to?
Belongs to the amino acid-polyamine-organocation (APC) superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RF1_SHESW
Sequence: MKESVIRKLEGLLERNEEVLALLGDASVIADQDRFRALSKEYSQLEEVVAGFKAYQQAQADLDSAKEMLEEDDAEMREMAQEEMKAAKAELERLESELQILLLPKDPNDDTNAFIEIRAGAGGDEAAIFAGDLFRMYSRYAEANRWQMEVMSCNEGEHGGFKEIIVKVSGEGAYGKLKFESGGHRVQRVPETESQGRVHTSAVTVVVMHEVPEAEAISINPADLKVDTFRSSGAGGQHVNKTDSAIRITHIPTGIVVECQDQRSQHKNRAQAMSVLAARIQAVEDEKRRSAEESTRRSLVASGDRSERVRTYNFPQGRVSEHRINLTLYRLNEVMEGDLDAILTPLMQEHQADLLAALADEQG
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CO2FA_CONLI
Sequence: MEKLTVLILVATVLLMIQVLAQSGGDKHLKRRPKQYATKRLSALMRGHRQCTPQNVQCEEDDECCSNLECKCSTVPDCNFPKCRP
What are the official names of this protein?
Conotoxin Lv15a.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TRMN6_ESCF3
Sequence: MSQSTSVLRRNGFTFKQFFVAHDRCAMKVGTDGILLGAWAPVAGVKRCLDIGAGSGLLALMLAQRTDDSVMIDAVELESEAATQAQENINQSPWAERINIYPADIQQWITQQTARFDLIISNPPYYQQGVECATPQREQARYTTTLDHQSLLTCAAECITEEGFFCVVLPEQIGNGFTELALRMGWHLRLRTDVAENETRQPHRVLLAFSPQAGECYSDRLVIRGPDQSYSEAYTALTQAFYLFM
What is the function of this protein?
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
What are the official names of this protein?
tRNA1(Val) (adenine(37)-N6)-methyltransferase, tRNA m6A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAFA_THEFY
Sequence: MERRIFGLENEYGVTCTFRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDNLLDLVAHDKAGERILEGLQIDAEQRLREEGIAGDIYLFKNNTDSAGNSYGCHENYLVARHGEFGKLADVLIPFLVTRQIICGAGKVLQTPRGALYCVSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERFRRLHVIVGDSNMSETTTLLKLASTDLVLRMIEANVPMRDFTLENPIRAIREISHDMTGRRKVRLANGREASALEIQREYLERVQSFVDRTGTDATGKRVLELWQRTLEAVESGNLDLVAREIDWVAKYKLLERYRAKHGLSLSSPRVAQLDLTYHDIHRDRGLFYLLQQRGQMERVVSDLRIFEAKSVPPQTTRARLRGEFIKKAQEKRRDFTVDWVHLKLNDQAQRTVLCKDPFKAVDERVEKLIAGM
What is the function of this protein?
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation.  This tagging system is termed pupylation.  The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
What are the official names of this protein?
Pup--protein ligase, Proteasome accessory factor A, Pup-conjugating enzyme.
What is the protein family that this protein belongs to?
Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
Protein: CT54B_CONMR
Sequence: ILLLLIASAPSVDAQLKTKDDVPLASFHANVKRTLQKLLNKRCCQIVPQCCEWN
What are the official names of this protein?
Conotoxin mr5.4b.
What is the protein family that this protein belongs to?
Belongs to the conotoxin T superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: G3P2_STRAW
Sequence: MTIRVGINGFGRIGRNYFRALLEQGADIEIVAVNDLGDTATTAHLLKYDTILGRLKAEVTHTADTITVDGKTIKVFSERNPADIPWGELNVDIVIESTGIFTKKADAEKHIAGGAKKVLISAPASDEDITIVLGVNEDKYDPAKHNVISNASCTTNCVAPMAKVLDENFGIVKGLMTTIHAYTNDQRILDFPHKDLRRARAAAENIIPTTTGAAKATALVLPQLKGKMDGISMRVPVPTGSATDLVVEVSREVTKDEVNAAFKKAAEGELQGYLSYTEDPIVSSDIVGDPSSCTFDSAMTMVMEGTSVKILGWYDNEWGYSNRLVDLTVFVGNQL
What is the function of this protein?
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD.  The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH.  The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 2, GAPDH 2, NAD-dependent glyceraldehyde-3-phosphate dehydrogenase, PL-sensitive glyceraldehyde-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.