PharMolix/UniProtQA huggingface dataset:
Protein: PSBM_AETGR
Sequence: MEVNILAFIATALFILIPTAFLLIIYVKTVSQND
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface.
What are the official names of this protein?
Photosystem II reaction center protein M, PSII-M.
What is the protein family that this protein belongs to?
Belongs to the PsbM family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: CCD22_DANRE
Sequence: MEEVDRILIHSLRQAGTDIDEDVQSVKQFTSELIVEAVVRCLRVIDPAVGNGLSHSLPPGMSARFRLGMSLAQACQDVGFKGEIGYQTFLYSNEPEIRSLFMFLVERLPRESAEASDQPAGKSVLLQRAIAAQIKAQLSVPWLPPTCRLPVHRKTQSSGPCHSFHAQPLSLPCSLKVSSRKQPKEVQEYWRNYLLPVTAQPSQPASVPASLLENHISELSAAQEWESEWNSQGLLSRLTPEEYRSRKKARLQKRIEEQLRTAAQPRPDTHGATRSTSDLAELLQSFGGASTGGDVLTKGTRFTHTEKFTFTQEPEKAVQQMAAAASALPSSQQSEEDLKAQQEAELSALQQQLQQLSVQMEEVGGGIKQLTVSIQQVTDELQTREVTNAERENSVKIKRQTIDLLPDAENNLLKLQSLVESSSKRVVQLASQWEKHRVPLIDEHRRLKELCSNRESESSRKLSEIKDLHDKIRQSAEEAKKKESLYKQLLTEFETLSKDVSRSAYTIRILEIVGNIKKQKEEITKILSDTKDLQKEINGLTGKLDRTFAVTDELVFKDAKKDESVRKSYKYLAALHENCTQLIQTIEDTGTIMREIRDLEEQIETENGKRTVSNLEKILEDYKAIRQENSALAAKIREG
What is the function of this protein?
May be involved in regulation of NF-kappa-B signaling.  May be involved in copper-dependent atp7a trafficking between the trans-Golgi network and vesicles in the cell periphery (By similarity).
What are the official names of this protein?
Coiled-coil domain-containing protein 22.
What is the protein family that this protein belongs to?
Belongs to the CCDC22 family.
Protein: PYDC4_HUMAN
Sequence: MVSSAQLDFNLQALLGQLSQDDLCKFKSLIRTVSLGNELQKIPQT
What is the function of this protein?
May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thereby inhibiting its transcriptional activity.  Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity.  May also play a role in cell cycle progression and apoptotic process.
What are the official names of this protein?
NLR family pyrin domain-containing protein 2B, Pyrin domain-containing protein 2-like protein POP4, Pyrin-only protein 4.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Targeted to the nucleus upon TNF- alpha treatment.
Protein: ARGD_GLOVI
Sequence: MTVQQAFEQHVMHTYARFSVVFERGEGCYLEDSEGRRYLDFVAGIATCVLGHAHPVLSAAVAEQARTLIHVSNLYYTPQQACLAEWLTAHSAADQVFFCNSGAEANEGAIKLARKYGRTVLGIAEPQIICAHQSFHGRTMATVTATGQPKYQKHFHPLVPGFVHVPYNDFEALRAQVTDATAAVLIEPIQGEGGVVPGDVEFFQKLRRFCSERRILLMLDEVQTGMGRTGRLFGYEHLGIEPDVFTLAKALGGGVPIGALCAKEAFAIFEPGDHASTFGGNPLACAAALAVCQTLEAEQLVDNARERGAQLAAGLGRLVERFKPLVRTARGRGLMQGLVLSEPRAAEIVRLAMEQGLLLVSAGPEVIRFVPPLIVSAIEVDEALAILEGVFARLPVTVTA
What are the official names of this protein?
Acetylornithine aminotransferase, ACOAT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE2_GRABC
Sequence: MIPGEVFSAPGEIILNDGLPVTTLVVANTGDRPVQIGSHYHFAEANPLLQFDREAARGQRLDIPAGTAIRFEPGQSREVPLIPYRGARIVHGFRNETGEAL
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DUSTY_BOVIN
Sequence: MEGDGVPWGSEPESGPGPGGGGVIRELCRGFGRYRRYLGRLRQNLRDTQKFFRDLRGSQPRGCPSSPAEGGEAGRGPAGDVAATGLPAGQLSCISFPPKEEKRLQQMVDCLPCILILGQDCSVKCQLLNLLLGVQVLPTNKLGGENCKLRRLRFTYGTQTRVSLALPDRYELVHTLAAHQGTWETVPEEDLEAREDSEDAARVLAELEVTMRHALLQEVDIVVAPCQGLRPTVDVLSDLVNDFLPVITYALHKDELSERDEQELQEIRKYFSFPIFFFKVPKLGSEIIDSSTERMESERSPLHRQLTDLGYLSSSLCNCGAPGQDTKAQSMLVEQSEKLRHLNTFSHQVLQTRLVDAAKALNLVHCRCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMIVETLNTMKEELLDDAANMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKLISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRMLWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAFAASLRQLEAGHSGRLEKTEDLWLKVRKDHAPRLARLSLESRSLQDVLLHRKPKLGQELGRGQYGVVYLCDSWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYSYGGGSSIAVLLIMERLHRDLYTGLKAGLALETRLQIALDVVEGIRFLHSQGLVHRDVKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPSQRPLLGIVQPMLQGIMDRLCKSHSERPNRGLDDST
What is the function of this protein?
Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation.  Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death.  In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types.
What are the official names of this protein?
Dual serine/threonine and tyrosine protein kinase, Dusty protein kinase, Dusty PK, Receptor-interacting serine/threonine-protein kinase 5.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Cell junction. Note=Detected in basolateral and apical membranes of all tubular epithelia. Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane.
Protein: SYC_BUCBP
Sequence: MLKIFNSYTRLQEQLEVDKKKTINMYVCGITAYDFCHIGHGRTFIFFDVVVRYLRSLGYALKYVRNITDIDDKIIAASLKNNESYISLSNRMISNMKDDFSALNILPPDSEPRVTENISDIIKFISILLNKKHAYVACNGDIMFSVSSYLNYGALSNQFSKILNKEINISHYSTKKNIADFALWKTSKSSIFVGWNSPWGNGRPGWHIECSSMCRSAFKNKIDIHGGGVDLLFPHHENELAQSVCIDSNFSIKHWMHTGLVIINNEKMSKSLNNTLLLRDLLTQYDSEIIRFFLLSTHYRHPLYFCYKNLSNSSKLLKKLYLSLRGVDFDIKGLDIVDNFKTDFYKAMNSDFNTPLALSILLRLSKEINKFKLIDSNKASQLASKLRQLGSILGILLKDPEYFLQNNFNCNNSIIGKINSLIYERDKARRVKDWVRADRIRKELLELGIVLEDTSFNTFWRSLQ
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH10_ECOLC
Sequence: MNIRPLHDRVIVKRKEVETKSAGGIVLTGSAAAKSTRGEVLAVGNGRILENGEVKPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
Protein: DGTL1_SHEPA
Sequence: MTDAVWNERRLGEDKQRRNDHRSPYQRDRARILHSAAFRRLQAKTQVLGVGMNDFYRTRLTHSLEVSQIGTGICAQLKQKQPQHNPLLDSMSLIESLCLAHDIGHPPFGHGGEVALNYMMRKHGGFEGNGQTFRILTRLEPYTEHFGMNLCRRTLLGILKYPAPYTNLCVGTPEESVDDFRQLKPSKWPPVKGIFDDDREILDWVLAPLSQQDRAKFLSSHVVKDIKHKRTRFKSLDCSIMELADDIAYAVHDLEDAIVMGIVSEQQWHTDVSLPLSQSNDPWLKNEFATISQRLFSAKHHLRKDAIGTLVNGFVTAIAITEVDGFEEPLLRYNAALEPAFHEALSILKQFVYKYVIRKPEIQMLEYKGQQIVMELFEAFISDPERLLPLNTQERWLAHERLGENSHRVIADYISGMTDGFAARLHQHLFSAKSHSMMDFNSDF
What are the official names of this protein?
Deoxyguanosinetriphosphate triphosphohydrolase-like protein.
What is the protein family that this protein belongs to?
Belongs to the dGTPase family. Type 2 subfamily.
Protein: Y12J_BPT4
Sequence: MKFFLGQTVELKGVGIPGLISKVLPPFKWSGIQIKEAYIVSWVDGNEDLRMGDELSPIYGLKELV
What are the official names of this protein?
Uncharacterized 7.3 kDa protein in Gp30-rIII intergenic region.
Protein: PROA_PARMW
Sequence: MTTVPEPSAELLQRAGAVRLAAVDLGQTDDQQRADALQAMADALAERAEVIVAANREDLERSAAEGLAPALMARLKLDAGKLRGAIDGVRKLASLPDPLGRRQLHRELDQGLVLERISVPLGVVGVIFEARPDAVVQIASLAIRSGNGAMLKGGSEARCTNEAVMEALKLGLGRSAVAPDALTLLTTRQESLALLRLDGLVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYVDAAADVDQAVRIAIDSKTQYPAACNAIETLLVHASIAPAFLASAVPAFQAAGVTLRGDEHSRQHGISDAATDEDWRTEYLDMILAVRVVPSMDAALEHIRRHGSRHTEAIATTDDQAAERFLGAVDSAGVYLNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLDGLVTYRYRLRGDGHIAADFADGTRSFTHTDLPL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SAA_FELCA
Sequence: MKLFTGLVFCSLVLGVSSQWYSFLGEAAQGAWDMWRAYSDMREANYIGADKYFHARGNYDAAQRGPGGAWAAKVISDARENSQRVTDFFRHGNSGHGAEDSKADQAANEWGRSGKDPNHFRPAGLPSKY
What is the function of this protein?
Major acute phase reactant.  Apolipoprotein of the HDL complex.
What are the official names of this protein?
Serum amyloid A protein, SAA.
What is the protein family that this protein belongs to?
Belongs to the SAA family.
What are the subcellular locations of this protein?
Secreted.
Protein: PSBA_HORVU
Sequence: MTAILERRESTSLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEVPAING
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
What are the official names of this protein?
Photosystem II protein D1, PSII D1 protein, Photosystem II Q(B) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: DEF_STRS7
Sequence: MSAQDKLIKAQHLIDMNDIIREGNPTLRAVAKEVEFPLSDDDIILGEKMMQFLKHSQDPVMGEKLGLRAGVGLAAPQIDVSKRIIAVLVPNPEDSEGNPPKEAYSMEEVLYNPKIVSHSVQDAALADGEGCLSVDRVVEGYVVRHARVTVEYYDKHNEKHRIKLKGYNAIVVQHEIDHINGVLFYDRINAKKPFEAKEGMLILE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: Y1372_STRPN
Sequence: MSNIYDSANELSRGLRGLPEYKAVKAAKDAIAADAEASKIFTDYLAFQEEIQKLAQTGQMPDASFQAKMEGFGKQIQGNSLLSEFFTKQQQLAIYLSDIEKIVFEPVSELLK
What are the official names of this protein?
UPF0342 protein SP_1372.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: SPNS1_DANRE
Sequence: MSQADADITPFFADDNEGEGPVENGVGSPLPEDEEEESPSGVTDRRAIMTVIVLCYINLLNYMDRFTVAGVLPDIEHFFGIGDGTSGLLQTVFICSYMFLAPLFGYLGDRYNRKLIMCVGIFFWSVVTLASSFIGKDHFWALLLTRGLVGVGEASYSTIAPTIIADLFVKEKRTNMLSIFYFAIPVGSGMGYIVGSKVDTVAKDWHWALRVTPGLGLLAVFLLMLVVQEPKRGAIEAHPEHTLHRTSWLADMKALCRNPSFILSTFGFTAVAFVTGSLALWAPAFLFRAGVFTGVKQPCFKAPCDDSDSLIFGAITVVTGILGVASGVQASKLLRTRTPRADPLVCAAGLLLAAPFLYLSIMFAQASTVATYVFIFLGETFLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAISPYLIGVVSDSIKESNSYMWEFRSLQMSLLLCSFVAVAGGAFFLATAVFIEKDRDLAENYVPSDDAPIVVPRSGRSTKVSVSSVLI
What is the function of this protein?
Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids (PubMed:36161949).  Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) (PubMed:36161949).  Essential player in lysosomal homeostasis (PubMed:27875093).  Critical for embryogenesis (PubMed:11836794, PubMed:18704191).  Involved in the regulation of developmental senescence (PubMed:27875093).
What are the official names of this protein?
Protein spinster homolog 1, Protein not really started, Spinster-like protein, Spns1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YIDD_PARMW
Sequence: MLAGIGFYRRFISPLIGPRCRFTPTCSAYGLEAIQRHGPWKGGWLTVKRLLRCHPFTPCGCDPVPD
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: PROB_SYNJA
Sequence: MAATEGTVVVKIGTSSLTDMQTGSLRLSVLGPLVEVLTRLRSQGYAVILVSSGAVGIGCARLGLRQRPTAIAEKQAVAAVGQGRLIRLYDDLFSALNQPIAQVLLTRGDFVERSRYVNANRTFTQLLQMGVIPIVNENDTVAVEELKFGDNDSLSALVASMVQAKWLILLTDVDRLYSADPHRDPSAEPIERVWRGMPLQIKAEAHGNSGWGTGGMATKLAAAQIATAAGVTVVITNGKRPDQIPAILAGEPIGTRFEPAPQPVSARKRWIAYGLIPEGSLTLDEGAVRAICEQGRSLLPAGITDVSGDFEAGAAVRLCDPGGREVGRGLVNYSAEELRRIKGKKTAEIPYILGYEGVDTAVHRDNLALLD
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL15_CYTH3
Sequence: MKLHTLRPAKGSVKTSKRIGRGTGSGRGGTSTKGHKGAKSRSGYSSKIGFEGGQMPLQRRLPKFGFKPLNKIEFKPINLDELLELIEKTGASVIDTALMNQNGLIGKNDKVKVLARGEVKSIKAEIIAHAFSASASEAITNAGGKVTLIG
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: QUEC_LARHH
Sequence: MDSLRDPEHALVVLSGGQDSTTCLYWALSRFAQVSAISFDYGQRHRVELDAARTIAAMAGVGHTIIPINTFSALGGNALTDQQMSPDTGPDAETLLPNTFVPGRNLVFLTFAAAWAWPRGIRHIVTGVAQTDYSGYPDCRENTLRALELAINLGMESRMRLHMPLMFLSKADTVTLARTVGAMPALAFSHTCYAGAVPPCGQCAACVLRAKGFAEAGIPDPLLNRLAGV
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: PGTB2_DICDI
Sequence: MTDNINKESTTTTTTIDHTTNLLIDKHVEYIVKLGSKKDSFEYWVTEHIRMNGMYWGLSSLYLLKSLDKLDKNEVIQWLLSCQKSNGGFGGNTSHDDHLLSTLSAVQILIQYDALDKIDINSVVDYVVKLQREDGSFVGDQWGEVDTRFSYAAIMCLSLLKSLDKINCEKAVEYILSCQNFDGGFGSIPGAESHAGQIFTCVGALSILNEINKIDIDKLGWWLSERQLPNGGLNGRPEKSSDVCYSWWVLSALSAIDRLHWIDNDKLKSYILKCQDNETGGIADKPGDIPDVFHTFFGICGLSLMGYFKDQIESIDPVYALGTKTLQKLGLNLPWNKNL
What is the function of this protein?
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal.
What are the official names of this protein?
Probable geranylgeranyl transferase type-2 subunit beta, Geranylgeranyl transferase type II subunit beta, GGTase-II-beta, Rab geranyl-geranyltransferase subunit beta, Rab GG transferase beta, Rab GGTase beta, Rab geranylgeranyltransferase subunit beta, Type II protein geranyl-geranyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit beta family.
Protein: MIAA_BACSU
Sequence: MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYKGMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVGGTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPNNTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMMQSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQLTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: C42S2_BOVIN
Sequence: MSEFWLCFNCCIAEQPQPKRRRRIDRSMIGEPTNFVHTAHVGSGDLFSGMNSVSSIQNQMQSKGGYGGGMAANVQMQLVDTKAG
What is the function of this protein?
Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly.  Alters CDC42-induced cell shape changes.  In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse.  May play a role in early contractile events in phagocytosis in macrophages (By similarity).
What are the official names of this protein?
CDC42 small effector protein 2.
What is the protein family that this protein belongs to?
Belongs to the CDC42SE/SPEC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Note=Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
Protein: PFD4_YEAST
Sequence: MELLPQGQRNNTQVTFEDQQKINEFSKLIMRKDAIAQELSLQREEKEYLDDVSLEIELIDEDEPVQYKVGDLFIFMKQSKVTAQLEKDAERLDNKIETLEDKQRDIDSRLDALKAILYAKFGDNINLER
What is the function of this protein?
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it.  Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
What are the official names of this protein?
Prefoldin subunit 4, Genes involved in microtubule biogenesis protein 3, Gim complex subunit 3, GimC subunit 3.
What is the protein family that this protein belongs to?
Belongs to the prefoldin subunit beta family.
Protein: PCKA_BACAA
Sequence: MSTVNVQIGLHELLNGSNAQIQLSVPQLVEKVLMRNEGKLTSTGAVSASTGKYTGRSPKDKFIVKEASVADKIAWGAVNQPISEEHFNKLYTKVLEYLKEKEELFVFKGFAGADRNYRLPIQVINEYAWHNLFVHQLFIRPTEEELTTHESEFTIVSAPNFKADPAVDGTNSEAFIMVSFEKRIVLIGGTEYAGEMKKSIFSIMNFLLPEQDILSMHCSANVGEEGDVALFFGLSGTGKTTLSADPNRKLIGDDEHGWSDNGVFNIEGGCYAKCVNLSHEKEPQIFDAITFGSVLENVIINDQTRIADYNDTTLTENTRAAYPMHAIDNIILPSVAGHPNTIIFLTADASGVLPPISKLSKEQAMYHFLSGYTSKLAGTERGVTSPQATFSTCFGSPFLPLDASRYAEMLGEKIEKHDAKVFLVNTGWTGGEYGVGKRMNLGYTRAMIQAALNGELAKTETAKHDIFGLEVPLHVPGVPDEVLMPEQTWADKAAYKAKAIELANEFKANFKKFDSVSEDIINLGGPIA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PA2A_BUNFA
Sequence: AVCVSLLGASIIPPQPLDLLQFNEMIECTIPGSFPLLDYMDYGCYCGTGGRGTPVDALDRCCKEHDDCYAQIKENPKCSSLLNVPYVKQYSYTCSEGNLTCSADNDECAAFICNCDRTAALCFAEVPYKRRNFRIDYKSRCQ
What is the function of this protein?
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Acidic phospholipase A2 KBf-grIB, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group I subfamily. D49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TIG_LIGS1
Sequence: MSIKWEKKDGTNEGKLTFEIAPEKIKEGLNSAFNRVKKSLNVPGFRKGKVPRQIFNKMYGEEALYQEALNDLLPEAYSNAVKEADINPVDQPQIDVESMESDAAWVLTAKVTVEPEVELGQYKDLEVTKHPTRVLKADIENELNRLQQQEAELVLKEDEPAEQGDTVVIDFEGKIDGEAFDGGKGENHSLELGSGQFIPGFEDQLVGHKAGEEVAVTVTFPEDYQAKDLAGKEAVFDTKIHEVKTKELPELDDEFAKDVDEDVATLEELKAKIKDRLKDQKVAEAKAAIQEEALDIAVENATIGEIPAVMIEDDVHRQMDNFLAGMQNQGISADMYYQLTGTSADDLHKQFEEGAEKRVKTNLVLEAIVKAEKIEPSEDEINAEIKSLAEQYQMDEAAVRSALSDDMLKHDIAVRKVVDEIADSAKQTRDAKKDEE
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: PTSS2_RAT
Sequence: MRRGERRVAGGSGSESPLLEGRRSTESEVYDDGTNTFFWRAHTLTVLFILTCALGYVTLLEETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRPHPAYWRFWLCVSVVYELFLIFILFQTVHDGRQFLKYVDPRLGVPLPERDYGGNCLIYDADNKTDPFHNIWDKLDGFVPAHFIGWYLKTLMIRDWWMCMIISVMFEFLEYSLEHQLPNFSECWWDHWIMDVLLCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAFQFTPYSWVRFEWKPASSLHRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNVGGVAMREIYDFMDELKPHRKLGQQAWLVAAITVTELLIVVKYDPHTLTLSLPFYISQCWTLGSILVLTWTVWRFFLRDITMRYKETRRQKQQSHQAINNGDGHPGPEDDLPGTGTAEEEGTTNDGVPAEEGPSAAS
What is the function of this protein?
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity).  Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity).  Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity).  Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity).
What are the official names of this protein?
Phosphatidylserine synthase 2, PSS-2, PtdSer synthase 2, Serine-exchange enzyme II.
What is the protein family that this protein belongs to?
Belongs to the phosphatidyl serine synthase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Highly enriched in the mitochondria-associated membrane (MAM).