PharMolix/UniProtQA huggingface dataset:
Protein: GRAH_HUMAN
Sequence: MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMKRL
What is the function of this protein?
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites.  Probably necessary for target cell lysis in cell-mediated immune responses.  Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
What are the official names of this protein?
Granzyme H, CCP-X, Cathepsin G-like 2, CTSGL2, Cytotoxic T-lymphocyte proteinase, Cytotoxic serine protease C, CSP-C.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Granzyme subfamily.
What are the subcellular locations of this protein?
Cytolytic granule.
Protein: EST1_MOUSE
Sequence: MWLCALSLISLTACLSLGHPSLPPVVHTVHGKVLGKYVTLEGFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYPPLCYQNPEAALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVIDGASTYDGVPLAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLFGRAARPLAKKIAALAGCKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDPRESYPFLPTVIDGVLLPKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMFLDFPLSERKLDQKTAASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMFGVPSVIVSRSHRDAGAPTYMYEYQYRPSFVSDDRPQELLGDHADELFSVWGAPFLKEGASEEEINLSKMVMKFWANFARNGNPNGEGLPHWPEYDQKEGYLQIGVPAQAAHRLKDKEVDFWTELRAKETAERSSHREHVEL
What is the function of this protein?
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.  Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester.  Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.  Converts monoacylglycerides to free fatty acids and glycerol.  Hydrolyzes of 2-arachidonoylglycerol and prostaglandins.  Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process.  First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile.
What are the official names of this protein?
Liver carboxylesterase 1, Acyl-coenzyme A:cholesterol acyltransferase, Carboxylesterase 1G, Cholesteryl ester hydrolase, CEH, ES-x.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum lumen. Cytoplasm. Lipid droplet. Note=Moves from cytoplasm to lipid droplets upon lipid loading. Associates with lipid droplets independently of triglycerides (TG) content of the droplets and hydrolyzes cholesteryl esters more efficiently from mixed droplets.
Protein: MGLA_CLOPE
Sequence: MKDSSNLLEMRNISKEFPGVKALDNVTLKVKKGSVHALMGENGAGKSTLMKCLFGIYHPNSGEIFISGQKVQFKNSKHALDNGVSMVHQELNQVRERNVMDNLWLGRYPKKGLFIDEKKMYDETEKIFKDLDINVNPRDKVSTLSVSQMQMVEIAKAVSYNSKIIVMDEPTSSLTEKEVSHLFKIINKLRKQGISIIYISHKMEEILEISDEVTIMRDGKWIATEKASDLTMDLIIKLMVGRELTDRFPKKDHIPKETTLEVNNLSDAKNELKNVSFKLRKGEILGIAGLVGAKRTETLETLFGLREKGSGDIILHGKKVDNSKPFKAMQNGFALVTEERRQTGIFGKLPIDFNSIIANIDSYKTSTGLLANERISKDTQWVIDSMKVKTPSQKTLIGSLSGGNQQKIVIGKWLLRKPEILLLDEPTRGIDVGAKFEIYQLINELAKEDKGIIMVSSEMPELLGVCDRILVMSNGRVSGIVNANETTQEEIMHLSAKYLSVTGGVNNANQIKEKV
What is the function of this protein?
Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Galactose/methyl galactoside import ATP-binding protein MglA.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MUKF_KLEP7
Sequence: MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAIATLNGERLEGEMSEGELVDAFRHVSDAFEQTSETISQRANNAINDLVRQRLLNRFTSEITEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAEEGGDEFHWHRNVFAPLKYSVAEIFDSIDLTQRIMDEQQQLVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLDAAGDKLQANLLRIQDSTMARDDLHFVDRLVFDLQSKLDRIVSWGQQAIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDEPWALTYANADRLLDMRDEEMALRDEEVTGELPADLEFEEFNEIREQLAALIEAQLAVYKEKGIPLDLGLVAREFLAQYPRGRHFDVARIVVDQAVQLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: GATA_NITOC
Sequence: MHHKSLAELASALKAREFSSEELTQHYLKRIERLNEDLNSFITVSTEEALKQAKAADAILQSGEGSSITGIPLAHKDIFCTTGVKTSCGSKMLDNFTAPYNATVVSRLKTAGAVMLGKTNMDEFAMGSSNETSFYGSVKNPWAHDRVPGGSSGGSAAAVAARLTPAATGTDTGGSIRQPAALCGITGLKPTYGRVSRYGMIAFASSLDQGGPMARTAQDAALLLNVMAGFDERDSTSVAQDVPDYTLSLEESIKGIKIGLPTEYFDENLNPGIAIPIEAAIKEFERLGAQIREISLPNTKLAVPTYYVVAPAECSSNLSRYDGTRFGYRCDNPKDLLELYCRSRGEGFGPEVKRRILIGTYVLSAGYYDAYYLKAQKLRRLISDDFKQALTEVDVIMGPTSPTPAFRLGEKSDDPVAMYLADIYTINVNLAGLPALSIPAGFAQGLPVGLQIIGNYFSESRLLNLAHRYQQVTDWHDRIPAGY
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: YQ6A_SCHPO
Sequence: MHSSRRKYNDMWTARLLIRSDQKEEKYPSFKKNAGKAINAHLIPKLSPKMNIMRSSCGRQEISQFQTKIRLFFLPHSCGVNDVTDLGGKDDELVGKRKKWKTEVRIETSMAECNGGKDFTEMTRIYLSIRKNFFQICLKTHSPQLPLGR
What are the official names of this protein?
Uncharacterized protein C191.10.
Protein: RS11_THEP3
Sequence: MAKRVKRAGRKREKKHVERGIAHIHSTFNNTIVTITDPAGNTISWASAGTIGFKGSRKSTPFAAQMAAESAAKSAMEHGMKTVDVYVKGPGAGREAAIRALQAAGLEVSLIKDVTPIPHNGCRPPKRRRV
What is the function of this protein?
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA.  Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
What are the official names of this protein?
30S ribosomal protein S11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS11 family.
Protein: SP110_CANGA
Sequence: MSDIKNFEFTPIGYIKSKSGENDAKETLMSPTGASVRSPGSVGHVRKARRRSINDTVNSSRVENDNDTFDETLPELEMRKLPQYRRVPESRTSARNSGAAPQEEQNRNDYSDILSKTSNPIKDQEQKIKDLEHENTVLKVKNVSYRSLLANYSGGSSQNNINLVEEVSIWKTKYLETNEKLLKVKQDFESYVQKMEQEKEVNTDQEKTKEPEVIPIDNPEYIKEREHILEELERVTEDFKNLRDRYNDLEIKFLSIQNELDEKKQEFESSTARLNEEIHTLKSTIDDKDATISEFKRKLGNAEDQLASIDDQNGNQNQKLLHDLKEREDAIDGLKEDIIEKENAIVHYKEEIQDKQNQLKESESKYAEVQKEFEDFKRELKKQTFEFEDGKKSTSRQLQELSVEKIQLEKQVCNLRGQIEKLEQQHRLTQSENDGLRTKLKHIESDLKNEKSRTEVKIKDLTSDLEDARKNLGEANNTIKELHHEIIKNATKSKDQLSEEVVEKDKEIDQLKHRVQRLDEELRTSQAELDKATKNREVDHELEIRRLQNKHEIEQESLKRELAHMTDEKERLVDLHRLDIETWERQIEALRKENENLISREHKESNNIEITLQDKNIQIRRLEADIVQLNEERNDILNKLRSLEQAKDRYKSEMKDALETISRLRVDLENNKSLKDSKDSLIERKYEKLKDEFKLMKKGYLDEMIKLQSRNRELNSDLQKRMDPSISTSANTTLADKLDYYKLKYNDEVRHNNDLRVINEYLNRVLRASAQDIRLNLLKVENDLNIDIHKENVPLSAPLSSSGGRPYSSSYTREFDKYDYRYRQKGKRFKTVALAVLAVIRMYRAAKKHNWNEQRIRYLQRKIIAKEDRITW
What is the function of this protein?
Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication.  Potential role in cross-linking filaments or anchoring other molecules.  It is essential for growth (By similarity).
What are the official names of this protein?
Spindle pole body component 110, Spindle pole body spacer protein SPC110.
What is the protein family that this protein belongs to?
Belongs to the SPC110 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Tightly associated with the nucleus. It is present in a granular pattern that excludes the nucleolus.
Protein: DNAK_HALOH
Sequence: MGKIIGIDLGTTNSCVAVLEGGEPTVIPNAEGNRTTPSVVAYTKKGERIVGEPAKRQAITNPDQTIRSIKRHMGTDHKVTLNDKEYTPQEISAMILQKLKRDAEEYLGEEVNEAVITVPAYFTDSQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKEGDKTILVFDLGGGTFDVSLLEIGDGVFEVVATSGNNHLGGDDFDKRIIDYLAENFKKEYGVDLRDDRMALQRLKDAAEKAKKELSSVKTTNINLPFITQTEDGPKHLDIDLTRAKFNELTEDLVEKTMGPTRQALKDAGLEPGDIDEVILVGGSTRIPAVQEAVKDFIGKAPHKGINPDEVVAMGAAIQAGVLAGDVDDIVLLDVTPLSLGIETLGGVFTKLIERNTTIPTSKKKVFTTAADNQTSVDIHVLQGERKLAKDNVTLGRFQLTGIPPAPRGVPQIEVKFDIDANGIVHVSAKDLGTGKKQQITIKSSSGLSEDEIEKMVNDARKHEEEDKKRLEEIEARNEADSLVYQTEKTLKESGDKVSKDVKDKVEKAKDELKKALEGDDVDQIKEKTEALKNELTELSSQLYAQAQQQAQQQAQGQQGAQTDNQTGQNDGKTIDVDYEEVDDDDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: NU4C_SORBI
Sequence: MSYFPWLTILVVLPIFAGSLIFFLPHKGNKIVRWYTIAICLLEFLIMTYAFCYHFQLEDPLIQLKEDSKWIDVFDFHWRLGIDGLSLGSILLTGFITTLATLAAWPVTRNSQLFYFLMLAMYSGQIGLFSSRDLLLFFIMWELELIPVYLLLSMWGGKRRLYSATKFILYTAGGSIFFLIGVLGMGLYGSNEPGLDLERLINQSYPTTLEILLYFGFLIAYAVKLPIIPLHTWLPDTHGEAHYSTCMLLAGILLKMGAYGLIRVNMELLPHAHYLFSPWLVIIGAVQIIYAASTSLGQRNFKKRIAYSSVSHMGFIIIGIGSITNIGLNGAILQILSHGFIGATLFFLAGTACDRMRLVYLEELGGISIPMPKIFTMFSSFSMASLALPGMSGFVAELVVFFGLITSPKFMLMPKMLITFVMAIGMILTPIYLLSMLRQMFYGYKLFHVPNKNFVDSGPRELFLLICIFLPVIGIGIYPDFVLSLSVDRVEALLSNYYTK
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase chain 4, chloroplastic, NAD(P)H dehydrogenase, chain 4, NADH-plastoquinone oxidoreductase chain 4.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: OSBL1_HUMAN
Sequence: MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKRYEGPLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY
What is the function of this protein?
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity).  Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980).  Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).
What are the official names of this protein?
Oxysterol-binding protein-related protein 1, ORP-1, OSBP-related protein 1.
What is the protein family that this protein belongs to?
Belongs to the OSBP family.
What are the subcellular locations of this protein?
Late endosome. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.
Protein: LHA1_RHOAC
Sequence: MNQGKIWTVVPPAFGLPLMLGAVAITALLVHAAVLTHTTWYAAFLQGGVKKAA
What is the function of this protein?
Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers.
What are the official names of this protein?
Light-harvesting protein B-800/820 alpha chain, Antenna pigment protein alpha chain, LH3 complex subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the antenna complex alpha subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein.
Protein: SRFB1_BOVIN
Sequence: MAEPETLNLNNEVVKMRKEVKRIRVLVIRKLVRSVGRLKSKKGREDALLKNQRRAQRLLEEIRAMKELKPDVVTKSALGEDINFEKICKKPDSTAAERAIARLAVHPLLKKKIDVLKAAVKSFKDARQNVVEVKSSNSASEENHSKDTLCSNDDASKLQHEGTIIREQKEKEAKILAKKPINNSKEKIAKMDHGPKAMDVPNSLSKPSGKDSPASSASQKTPSDPKMKALSKTKKMKESSSSLDVDSDGEELYEEEKEYFDDSTEERFYKQSSMSEDSDSGDDFFIGKVKRARKKESSCRFSDKEQNPPKNLLLEEGILETHQNLQNDKNKPRTEARRFESVFFQSLSGSKSLERNHREQVPRSKTMDFQHIEPQNKNQFNKKAQRGFENTKQKSQLPLHPSWEASRRRKEQQSKIAVFQGKKITFDD
What is the function of this protein?
May be involved in regulating transcriptional activation of cardiac genes during the aging process.  May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).
What are the official names of this protein?
Serum response factor-binding protein 1, SRF-dependent transcription regulation-associated protein.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region.
Protein: Y3951_RHIEC
Sequence: MSAADVEYRVRHQAFWFVACLAVLVAQIIAEYLMGRVPICACGYVKLWEGGVNTSGNSQHLSDWYTPSHIIHGFLFYGLGYLILRRKPLAARLLLALMIESGWELLENSPLIIDRYRTATMALDYYGDSILNSAMDTVFMCLGFFFAARAPVALTVVIAIFFEIFTGYVIRDNLTLNVLMLIWPVEAIKVWQGGL
What are the official names of this protein?
UPF0314 protein RHE_CH03951.
What is the protein family that this protein belongs to?
Belongs to the UPF0314 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IDHP_RAT
Sequence: MAGYLRAVSSLCRASGSTRTWAPAALNVPSWPEQPRRHYAEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGKQ
What is the function of this protein?
Plays a role in intermediary metabolism and energy production.  It may tightly associate or interact with the pyruvate dehydrogenase complex.
What are the official names of this protein?
Isocitrate dehydrogenase [NADP], mitochondrial, IDH, ICD-M, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Protein: SYT_BACTN
Sequence: MIKITFPDGSVREYNEGVNGLQIAESISSRLAQDVLACGVNGETYDLGRPINEDADFVLYKWDDEEGKHAFWHTSAHLLAEALQELYPGIQFGIGPAIENGFYYDVDPGEAVIKESDLPAIEAKMLELSAKKDAVVRESISKTDALKMFGDRGETYKCELISELEDGHITTYTQGAFTDLCRGPHLMTTAPIKAIKLTTVAGAYWRGHEDRKMLTRIYGITFPKKKMLDEYLVLLEEAKKRDHRKIGKEMQLFMFSETVGKGLPMWLPKGTALRLRLQEFLRRIQTRYDYQEVITPPIGNKLLYVTSGHYAKYGKDAFQPIHTPEEGEEYFLKPMNCPHHCEIYKNFPRSYKDLPLRIAEFGTVCRYEQSGELHGLTRVRSFTQDDAHIFCRPDQVKDEFLRVMDIISIVFRSMNFQNFEAQISLRDKVNREKYIGSDDNWEKAEQAIIEACEEKGLPAKIEYGEAAFYGPKLDFMVKDAIGRRWQLGTIQVDYNLPERFELEYMGSDNQKHRPVMIHRAPFGSMERFVAVLIEHTAGKFPLWLTPDQVAILPISEKFNEYAEQVKMYLKMHEIRAIVDDRNEKIGRKIRDNEMKRIPYMLIVGEKEAENGEVSVRRQGEGDKGTMKYEEFAKILNEEVQNMINKW
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GVPA_DACSA
Sequence: AVEKTNSSSSLGEVVDRILDKGVVVDLWVRVSLVGIELLALEARVVI
What is the function of this protein?
Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms.  They allow the positioning of the organism at the favorable depth for growth.  GvpA type proteins form the essential core of the structure.
What are the official names of this protein?
Gas vesicle structural protein, GVP.
What is the protein family that this protein belongs to?
Belongs to the gas vesicle protein type A family.
What are the subcellular locations of this protein?
Vacuole, gas vesicle membrane.
Protein: CR3L2_RAT
Sequence: MEVLESGEQSVLQWDRKLSELSEPGETEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLSEEPRAQSPFTHVAASDGFNDEEVESEKWYLSTEFPSATIKTEPITEEQPPGLVPSVTLTITAISTPFEKEESPLDMSAGGDSSCQTLIPKIKLEPHEVDQFLNFSPKEASVDQLHLPPTPPSSHSSDSEGSLSPNPRLHPFSLSQAHSPGRAMPRGPSALSTSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSLFQGYGLYPSATKMALPSQHPLSEPYTASVVRSRNLLIYEEHSSLEESSSPASAGELGGWDRGSSLLRASSGLEALPEVDLPHFIISKETSLEKSVLLELQQHLVSSKLEGNETLKVVELERRVNATF
What is the function of this protein?
Transcription factor involved in unfolded protein response (UPR).  In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane.  In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2.  The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes.  Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes.  In a neuroblastoma cell line, protects cells from ER stress-induced death.  In vitro activates transcription of target genes via direct binding to the CRE site.
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 2, cAMP-responsive element-binding protein 3-like protein 2, SCI-related protein Ra69.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element- binding protein 3-like protein 1) is transported into the nucleus. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus. Note=Upon ER stress, translocated into the nucleus.
Protein: UBIC_PSEF5
Sequence: MPHSMPPAPAPIWLVQSRLSPFPGTAVANWLFDEGSLTRRLTRLSHNAFSVTPLVQEWQTLRNDECAALGLPEQSEGWVREVYLRGHGQAWVFARSVAARSALLEGGLNIDELGSRSLGELLFCDQAFTRQPIEVCRYPRHWLPAAVADNGLWGRRSRFDRGPLSLLVAEIFLPSLWTAIDARPEAC
What is the function of this protein?
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
What are the official names of this protein?
Probable chorismate pyruvate-lyase, CL, CPL.
What is the protein family that this protein belongs to?
Belongs to the UbiC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA_STRPI
Sequence: MKTKIIVIVGPTAVGKTALAIEVAKRFNGEVVSGDSQQVYRGLDIGTAKASPEEQAAVPHHLIDVREITESYSAFDFVSEAKMTIEDIQSRGKLAIIAGGTGLYIQSLLEGYHLGGETPYEEILAYRASLEPYSDEELAHLVEQAGLEIPQFNRRRAMRALEIAHFGQDLENQEILYEPLIICLDDERSQLYERINHRVDLMFEAGLLDEAKWLFDHSPNVQAAKGIGYKELFPYFRGEQTFEEARESLKQATRRFAKRQLTWFRNRMQVTFYQIGESGVQDRILSQIEEFLDD
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: FPR2_MOUSE
Sequence: MESNYSIHLNGSEVVVYDSTISRVLWILSMVVVSITFFLGVLGNGLVIWVAGFRMPHTVTTIWYLNLALADFSFTATLPFLLVEMAMKEKWPFGWFLCKLVHIVVDVNLFGSVFLIALIALDRCICVLHPVWAQNHRTVSLARKVVVGPWIFALILTLPIFIFLTTVRIPGGDVYCTFNFGSWAQTDEEKLNTAITFVTTRGIIRFLIGFSMPMSIVAVCYGLIAVKINRRNLVNSSRPLRVLTAVVASFFICWFPFQLVALLGTVWFKETLLSGSYKILDMFVNPTSSLAYFNSCLNPMLYVFMGQDFRERFIHSLPYSLERALSEDSGQTSDSSTSSTSPPADIELKAP
What is the function of this protein?
High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophil chemotactic factors (PubMed:12218158, PubMed:10477558, PubMed:19387439).  Stimulates chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation (PubMed:10477558, PubMed:19497865).  Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (PubMed:29138422).
What are the official names of this protein?
Formyl peptide receptor 2, Formylpeptide receptor-related sequence 2, Lipoxin A4 receptor-like protein, N-formylpeptide receptor-like 2.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized.
Protein: UB4AA_ONCMY
Sequence: MILTVKPLQGKECNVQVTEDEKVSTVKELVSERLNIPASQQRLLYKGKALADEHRLSDYSIGPEAKLNLVVRPAGERSGVAGMASSSSAVGGVWQTLSTVLAKHFSPADAAKVQEQLVKDYERSLRQLSMDDIERLAGRLLHPDSEGMDTSYMD
What is the function of this protein?
Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane.  TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region (By similarity).
What are the official names of this protein?
Ubiquitin-like protein 4A-A.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: PYRR_ELUMP
Sequence: MEKLIKDGEELNRTLDRMAHEILEKHEIDNTLALVGIRTRGIYIARRLMEKIKKITGKDVLYGELDITLYRDDLSQVAEQPVLKATNIPFDITGKTIILTDDVLYTGRTIRSALAALSDFGRPSRIELAVIVDRGHRELPIKADYVGKNLPTAKTEIVHIKLKEYDGEDSITLLVKNND
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.