PharMolix/UniProtQA huggingface dataset:
Protein: STHA_PSEAE
Sequence: MAVYNYDVVILGTGPAGEGAAMNASKYGRKLAVVDSRRVVGGNCTHLGTIPSKALRHSVKQIIEFNTNPMFRQIGEPRWFSFPDVLKSADRVISKQVASRTGYYARNRIDMFTGTASFVDERTVEVVTPSGAVERLVADQFVIATGSRPYRPSDINFNHPRVYDSDTILSLSHTPRRLIIYGAGVIGCEYASIFSGLGVLVDLIDTRDQLLSFLDDEISDALSYHLRNNNVLIRHNEEYERVEGLDNGVILHLKSGKKIKADALLWCNGRTGNTDKLGLENVGIKVNSRGQIEVDENYRTSVSNIFAAGDVIGWPSLASAAYDQGRSAAGNIVESDSWRFVNDVPTGIYTIPEISSIGKNESELTAAKIPYEVGKAFFKGMARAQISNEPVGMLKILFHRETLEILGVHCFGDQASEIVHIGQAIMNQPGELNTLKYFVNTTFNYPTMAEAYRVAAFDGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RKM5_YEAS8
Sequence: MAFKLWLLDEETIYEHVFERYTQLEGQSGKLAQDLGIQDRRGGVLEITFEPSGLEGGRKKKRVRRRNKASSVEEDQNVAVDSYHVSVGQSISSLHSSRDNGNSTTGYVLWSTTPFFINWLLYSTSAAPFRLGSQVEVTCGSSCEGHMLELPRLIDLTGADRGKRGILELGAGISGILPVILGNFVDTYVSTDQKGILNKLKDNIMENLSQLTRKRCISRSLRLELPTVEPVGDADITAASLPSKSTLHLEVAALDWEKINLQDKKTHSLHPELSLIGETCSSVYVIAMDVIYNEYLIDPFLKTLKQLKHWLQTTYNLQFHVLVGIHLRSQEVTTLFLEKAIIEYDFTVYDIVDQVIQESRFNFYLIT
What is the function of this protein?
S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L1 (RPL1A and RPL1B) at 'Lys-46'.
What are the official names of this protein?
Ribosomal lysine N-methyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RKM5 family.
Protein: RS9_PSEPG
Sequence: MSATQNYGTGRRKTATARVFLRPGTGNISINNRSLDVFFGRETARMVVRQPLELTETVEKFDIYVTVSGGGVSGQAGAIRHGITRALMEYDETLRGALRRAGYVTRDAREVERKKVGLRKARKRPQYSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: NAC74_ORYSJ
Sequence: MESLRDMVLPPGFGFHPKDTELISHYLKKKIHGQKIEYEIIPEVDIYKHEPWDLPAKCDVPTQDNKWHFFAARDRKYPNGSRSNRATVAGYWKSTGKDRAIKMGKQTIGTKKTLVFHEGRPPTGRRTEWIMHEYYIDERECQACPDMKDAYVLCRITKRNDWIPGNGNELDNSDPHPEPYDAPPSVISTEQLNPAAEPVVGVEAAPVTVAEPDGVTTSAITANIPSPSDDINLDDWLNELFDPFFDPEQSLASADLSPDEQNVESSNVGALAPKVEQDYSSPNENVVDDTEYLLPEDVYNILHPGTDDFNMLQNPLDQYPIQYATDVWSGIQKEELWSPQANAEPSQSNEAADNGIIRRYRSMKTPETSVPQFKGKTQAKMRVGINKMATSSSESINQTIKFENSGRLVEHQKNQAHDVASTKRSDAGKPSTELSSNRGFLRGIRNAFAGCSDARWNMILVAGFAIGVAVVALHIGQRLGLSQRDQQHT
What is the function of this protein?
Transcription activator involved in heat and endoplasmic reticulum (ER) stress responses (PubMed:31733092).  Regulates the expression of genes involved in ER protein folding and heat stress-responsive genes (PubMed:31733092).  Binds directly to the promoter of BZIP74 and regulates its expression in response to heat stress (PubMed:31733092).
What are the official names of this protein?
NAC domain-containing protein 74, ONAC074, OsNAC8, Protein NTM1-like 3, OsNTL3.
What are the subcellular locations of this protein?
Nucleus. Cell membrane; Single-pass membrane protein. Note=NTL3 relocates from plasma membrane to nucleus in response to heat and endoplasmic reticulum (ER) stresses.
Protein: WECG_YERP3
Sequence: MEPNTVIPKYNVRGFEIWGFRDMAQVLDHLLGSGPVKTGTLVAMNAEKLLKAEDDTALCELIKNAEYLYADGISMVRAIRRKYPQAELSRVAGADLWEALMQRAGQQGTPVFLVGGKPDVLAETEAKLRAQWNVNLVGSQDGYFTPEQREALFARIAASGAAIVTVAMGSPKQEIFMRDCRKFYPDALYMGVGGTYDVFTGHVKRAPKIWQNMGLEWLYRLLAQPSRIRRQLKLLKFVGYYYSGRL
What is the function of this protein?
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
What are the official names of this protein?
UDP-N-acetyl-D-mannosaminuronic acid transferase, UDP-ManNAcA transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 26 family.
Protein: INP1_CANGA
Sequence: MSTVKQRTRTEGKPQYPLMQSIKDTLKLKTTKRTNSEKKVSTLNDKSGSPIKSNSERRNGITRKVNGSKRLSAQRVALFKYNNVQVFNYVRNGNNSRKSSMSSLNSSGTVVMCNEYDSEVTNLKPQMLIGKGVLELYQIKTPAALDRKEQTMNYISLGRGGQIVHPILPKLKITKLRNENFKYLITFSNPERYWQIEFLQINGQLHDELLKITDEFESIISSVCIFIDENITKLASLKSNKTPPNNVNTLDQIKEKVQTATENDDDEAEELDYLLEDPIEQEPTSSFEYDVPTDLTEVFQRTMGRINSNGSRRYSSVPQFSHRRSMIRRSMSLFPEHEGRFS
What is the function of this protein?
Required for peroxisome inheritance.
What are the official names of this protein?
Inheritance of peroxisomes protein 1.
What is the protein family that this protein belongs to?
Belongs to the INP1 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Peripheral membrane protein.
Protein: PURL_MYCVP
Sequence: MTQEVDTVERAAATPDHPQPYRELGLKDDEYERIREILGRRPTDAELAMYSVMWSEHCSYKSSKVHLRYFGETTTEKMRETMLAGIGENAGVVDIGDGWAATFKVESHNHPSYIEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVVRGIGGYGNSLGLPNIGGETVFDASYAGNPLVNALCVGVLRKEDLKLAFASGAGNKIILFGARTGLDGIGGVSVLASETFGGDESGAGRKKLPSVQVGDPFTEKVLIECCLELYAADLVVGIQDLGGAGLSCATSELASAGDGGMRVELERVPLRAANMTPAEILSSESQERMCAVVTPDNVDAFMAVCRKWDVLATDIGEVTDSGRLEITWHGETVVDVPPRTVAHEGPVYERPVQRPDSQDALVANTTASLERPSTGDELRATLLQLLGSPALCSRAFITEQYDRYVRGNTVLAEHADGGVLRVDEQTGRGIAISTDASGRYTALDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFSQAVRGLADGAAALGIPVTGGNVSFYNQTGTTAILPTPVVGVLGVIDDVKRRIPTGFGTEPGETLILLGDTRDEFDGSIWAQVTADHLGGVPPTVDLDRERLLAEVLTAASRDGLVSAAHDLSEGGLIQAVVEASLAGETGCRIVLPEGWNPFVTLFSESAGRVLVAVPRTEESRFTAMCEARGLPANRIGVVDQGPDGGEPAVEVQGLFTVTLEELRRTSEGVLPGLFG
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOB_BRUC2
Sequence: MPDRGGENGASCSVGRWSAEEARAIYNLPFNDLLFRAHGLHRENFDPNRIQLSKLLNIKTGGCPEDCGYCSQSASAENGLKASKLMEIETVLEEARKAKAAGATRYCMGAAWRSPKDRDMPALTHMIESVKAMGLETCMTLGMLDSDKAEKLADAGLDYYNHNIDTSERFYPAVITTRSFEDRLDTLANVRNAGIKVCSGGILGLGEEAEDRIDMLVTLANLPEPPESVPINMLIPMPGTRLAKAAPVDPLEFVRVVALARILMPKSHVRLTAGRTAMSDEMQALCFFAGANSLFMGDTLLTAANPGDDRDSSLLRRLGIQAETEQPA
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: ISPE_PARXL
Sequence: MIETTDSLRDCLAPAKLNLFLHITGRRPDGYHTLQTVFQLLDWGDTLHFTRRDDGLITRRTEIADVPPEHDLTVRAATLLKTHTGSPEGVDIEIDKRLPMGAGLGGGSSNAATTLLALNRLWKLNLPRLELQALALKLGADVPFFVFGKNAFAQGVGEALDVVQLPPRHFLVVTPRVHVPTAAIFSEKALTRDSKPLTITDFPAELSCNTEWPESFGRNDMQQVVVGKYAEVAQVLRWFENVAPARMSGSGASVFAAFRSKAEAEAVQAKLPAEWNSAVAASLDQHPLFTFAS
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: RPOZ_BURCM
Sequence: MARITVEDCLKQIPNRFELALAATYRARQLAQGHTPKIESRDKPTVVALREIASGLVGVEMLKKVPV
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: TSN_PONAB
Sequence: MSVSEIFVELQGFLAAEQDIREEIRKVVQSLEQTAREILTLLQGVHQGAGFQDIPKRCLKAREHFGTVKTHLTSLKTKFPAEQYYRFHEHWRFVLQRLVFLAAFVVYLETETLVTREAVTEILGMEPDREKGFHLDVEDYLSGVLILASELSRLSVNSVTAGDYSRPLHISTFINELDSGFRLLNLKNDSLRKRYDGLKYDVKKVEEVVYDLSIRGFNKETAAACVEK
What is the function of this protein?
Exhibits both single-stranded and double-stranded endoribonuclease activity.  May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand (By similarity).
What are the official names of this protein?
Translin, Component 3 of promoter of RISC, C3PO.
What is the protein family that this protein belongs to?
Belongs to the translin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RNC_BORA1
Sequence: MSLATLETRLGHHFGDQALLEQALTHRSHGARHNERLEFLGDSVLNFVVAAMLFERYAKLDEGDLSRVRANLVKQASLADIAQRLELSPYLRLGEGEMKSGGFRRPSILADAVEALFGAVFLDAGFDAARKVIEQQYVPVLANVDPETLGKDAKTLLQEFLQGRKLALPLYTVVATHGAAHSQQFEVECAIPALEIKVTAAGASRRAAEQSAAKLALEAALVVSPRATRKGGRARKTAQLSLPVAVAQEVK
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NADE_BURPS
Sequence: MSRPDQAARRRAIAAELHVSPTFDARDEAERRIGFVADYLRTAGLRACVLGISGGIDSSTAGRLAQLAVERLRASGYDARFVAMRLPYGAQHDEADARRALAFVRADETLTVDVKPAADAMLAALAAGGLAYLDHAQQDFVLGNIKARERMIAQYAVAGARNGVVIGTDHAAESVMGFFTKFGDGGADVLPLAGLTKRRVRALARMLGADEPLVLKTPTADLETLRPQRPDEHAYGITYEQIDDFLEGKPMDDAVAETVLRFYDATRHKRALPYTMFDWPGHPA
What is the function of this protein?
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.  Uses ammonia as a nitrogen source.
What are the official names of this protein?
NH(3)-dependent NAD(+) synthetase.
What is the protein family that this protein belongs to?
Belongs to the NAD synthetase family.
Protein: GLYA_XYLFT
Sequence: MFPRDARLDMYDPELAKAIAAEVRRQEDHVELIASENYCSTLVMQVQGSQLTNKYAEGYSGKRYYGGCEYVDIAEQLAIERAKKLFGADYANVQPHSGSQANQAVYFALLQPGDTILGMSLAHGGHLTHGANVNVSGKLFNAVQYGVNAQGLIDYEAVESLALEHRPKMVVAGFSAYSQKIDWARFRAIADQVGAYLLVDMAHVAGLVAAGVYPSPLPHAHVVTSTTHKTLRGPRGGIIVAQAPQEALVKKLQSIVFPGIQGGPLMHVIAAKAVAFKEALEPAFKVYQQQVVKNAKAMAGTLMLRGYKIVSGGTENHLMLVDMIGRDVSGKDAEGALGQVHITVNKNAVPDDPRSPFVTSGLRLGTPAVTTRGYQEQDCVDLAHWIADVLDAPADVTVIAAVREKVAAQCKKYPVYR
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWET8_ARATH
Sequence: MVDAKQVRFIIGVIGNVISFGLFAAPAKTFWRIFKKKSVEEFSYVPYVATVMNCMLWVFYGLPVVHKDSILVSTINGVGLVIELFYVGVYLMYCGHKKNHRRNILGFLALEVILVVAIILITLFALKGDFVKQTFVGVICDVFNIAMYGAPSLAIIKVVKTKSVEYMPFLLSLVCFVNAGIWTTYSLIFKIDYYVLASNGIGTFLALSQLIVYFMYYKSTPKEKTVKPSEVEISATERV
What is the function of this protein?
Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.  Required, in pollen, for microspore cell integrity and primexine pattern formation (PubMed:18434608, PubMed:25988582).
What are the official names of this protein?
Bidirectional sugar transporter SWEET8, AtSWEET8, Protein RUPTURED POLLEN GRAIN 1, Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 8.
What is the protein family that this protein belongs to?
Belongs to the SWEET sugar transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HUTI_STRPM
Sequence: MVADVLLTHFNQLFCLNDPGHPLTGQEMKKATIVEDGYIAIKDGLIVALGSGEPDAELVGPQTIMRSYKGKIATPGIIDCHTHLVYGGSREHEFAKKLAGVSYLDILAQGGGILSTVRATRSASFDNLYQKSKRLLDYMLLHGVTTVEAKSGYGLDWETEKRQLDVVAALEKDHPIDLVSTFMAAHAIPEEYKGNPKAYLDVIIKDMLPVVKEENLAEFCDIFCEKNVFTADESRYLLSKAKEMGFKLRIHADEIASIGGVDVAAELSAVSAEHLMMITDDGIAKLIGAGVIGNLLPATTFSLMEDTYAPARKMIDAGMAITLSTDSNPGSCPTANMQFVMQLGCFMLRLTPIEVLNAVTINAAYSVNRQERVGSLTVGKEADIAIFDAPNIDYPFYFFATNLIHQVYKKGQLTVDRGRIL
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BABA2_DANRE
Sequence: MNSLSPELALSRISPELRPLLCSIVRNGRVGLDSSSCLRITDLKSGCTSLMPGPCCDRFKLHIPYAGETLKWDIIFNARDPELPPDFIFGEDADFLPEPSELPNLVSWDSGKPECLLLLVKEMLQQYHQYQCQRLRDSSRLLFEYDSLLEDPNYGRNMEIYAGRKNSWTGEFSARFLLKLPVDFSNIPIYLLKDTALDPGEDVALLSVSFEDAEATQVFPKLYLSPSIEHALGGSSALHIPAFPSGGCLIDYVPQVCQLLTNKVQYVIQGYHKRREYIAAFLSHFGMGVVEYDAVGFTKLTLLLMWKDFCFLVHVDLPLYFPRDQPTLTFQSIYHFTSSGQLYSQVQKSYPYSPRWDGNEMAKRAKAYFKSFIPQFQEGAFANGKL
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the brca1-bard1 heterodimer.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  Within the BRISC complex, acts as an adapter that bridges the interaction between babam1/nba1 and the rest of the complex, thereby being required for the complex integrity.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating numa1.  The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor ifnar1; deubiquitination increases ifnar1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in ifnar1 deubiquitination.  May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins.  May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.
What are the official names of this protein?
BRISC and BRCA1-A complex member 2, BRCA1-A complex subunit BRE, BRCA1/BRCA2-containing complex subunit 45, Brain and reproductive organ-expressed protein.
What is the protein family that this protein belongs to?
Belongs to the BABAM2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: OC116_CHICK
Sequence: MRATLFCLCLCLLGTVLPTPVSLPARARGNCPGQHQILLKGCNTKHGFYIFQYIYSHLMQKNQTQVKKEEGDHQGTIHGHWLGKVDGEAPGQGAGSSHVPEDKDSPKTHSHITPASKGEGRALRPGIGDSNSVYPTSTSVEGSGDMGSILLGEIINGEDGLPQSTHPGGPHGDGDGGNGVLVDGAVTAGRERASGSEGAGSEGGSHAPVPDQGQAGTMGTGDSAITSVTDSAITSVTKKEDVHVDTEGIDEFAYIPDVDAVTITRGQDGETHISPEDEVKIFIGRANIQVGENDSSVGSAGATSEANVIPTVVTVRPQGHPEESATMATLHHGDSVTSRPVGHPSVGNSGDGATEIHSGQELEAPSPWESTGGDATVTMAVGVQSGKGRSGQRALGKHSLPATMTTRGGRGTASSGLTTGDCSTAASTPSRKGSHVVSAGQGESGEVGTAGPERQRARVQQEVAPARGVVGGMVVPEGHRARVQQEVAPARGVVGGMVVPEGHRARTQPEVASAPSTVGKAAPERHRNRAQQEVAPVPSMVVETVAPERHRARVRPESARLGQAARPEVAPAPSTGGRIVAPGGHRARVWPGAAPAPGVVGVARPAPSKAYNGDKRVAIGKSTDVPRDPWVWGSAHPQAQHTRGSTVAGGFAHLHRGQRLGGLTEMEHSRQVEQVRHADRLRLHERAVYGLSGVGGPLQPPAVHTDPWSADSSQSSEGRWGSHSDSHEEDGEVRGYPYGRQSL
What is the function of this protein?
Major component of the eggshell matrix.  May play an important role in the regulation of calcite growth during eggshell calcification.  May also regulate the mineralization process in developing and growing bones.
What are the official names of this protein?
Ovocleidin-116, OC-116.
What is the protein family that this protein belongs to?
Belongs to the osteoregulin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Note=Synthesized and secreted by the granular epithelial cells of the uterus and incorporated into the eggshell matrix.
Protein: CPLX3_MOUSE
Sequence: MAFMVKSMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQLAGGDVELPRELAKMIEEDTEEEEDKASVLGQLASLPGLDLSSLKDKAQTTLGDLKQSAEKCHIM
What is the function of this protein?
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896).  Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896).  Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398).  Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (PubMed:22694764, PubMed:27335398).
What are the official names of this protein?
Complexin-3, Complexin III, CPX III.
What is the protein family that this protein belongs to?
Belongs to the complexin/synaphin family.
What are the subcellular locations of this protein?
Synapse. Cell membrane; Lipid-anchor. Note=Enriched at the synaptic terminal (PubMed:15911881). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (PubMed:22694764).
Protein: OTC_NEIPO
Sequence: KTSTRTRCAFEVAARDQGAGATYLEPSASQIGHKESIKDTARVLGRMYDAIEYRGFGQEIVEELAKYAGVPVFNGLTNEFHPTQMLADALTMREHSSKPLNQTAFAYVGDARYNMGNSLLILGAKLGMDVRIGAPESLWPSEGIIAAAHAAAKETGAKITLTENAHEAVKGVGFIHTDVWVSMGEPKEVWQERIDLLKDYRVTPELMAASGNPQVKFMHCLPAFHNRETKVGEWIYETFGLNGVEVTEEVFESPASIVFDQA
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IL33_CANLF
Sequence: MKYSTTKIPPAKMNSSADKALVKSPKLRKSQQKPEGVCQMYFMQLRSGLIIEKTSCYFRKEITKRYSPRTAEKCRKQCLVFTACHQQLNKDFTSDVPMLQKCFGRANVPSIQEYSASLSTYNDQSITFVFEDGSYEIYVEDLRKGQEKDKVLFRYYDSQSPSHETGDDVDGQTLLVNLSPTKDKDFLLHANNEEHSVELQKCENQLPDQAFFLLHRKSSECVSFECKNNPGVFIGVKDNHLALIKVGDQTKDSYIEKTIFKLS
What is the function of this protein?
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets.  This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity).
What are the official names of this protein?
Interleukin-33, IL-33, Protein DVS27.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family. Highly divergent.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
Protein: ADCY2_DROME
Sequence: MVNHNAETAKTGNGTNATANLIVKADGNATQPKAMTSSAARMNDALSASLADLSEQENGTTAEDIHLNDLYTRYRQRLRKSLFRSGLLTSLLACVVSIIIGIVYGQHLVQTMLLVLAALISGSILTALQFPAVLSSPAAALAFAIVTTFSLGTIAAITGDELAPLPMYALFLCIHSMLPISWPVSVVLALFMTAIHIVYRIGTSPDYAPNLPMLFGEIVMLASASVSGLYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQRAGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINVDMRIGIHTGNVLCGVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHITKQTLDFLGDKFEVEQGEGGNRDAYLADHKVESYLIVPPKPAYTYSVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSPTSINSQEAPLHAPLASAASMSIKELSEEEDEADEATAVTEPLMHRDQDGKNDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQGLMSFADRRRSSGAFIEGRKLSIHSGESFRSHAGHVTRNRPSSKMTKYVECWGADRPFANIAESKLVKNIGLASIAMIESNLLPPERKCFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICAFVLFLSLAVVQLIVIELNLALLGSLLASFVSLALFLYLSNMSVPDVHASTTERNGPGQVVASSRYLRLAMFVVVNILISSCAVFSVINYTVPDGVSKEPSSNQTILESNFSSVFVNSTLEDVQLWEIDYAIPIAPVFLYCCAISLAAISAFLRSGFILKLIAMLVAVIAQVTVLGYSDLFEMYNDANITHGLPLEIKGFLLLLVIILVLHTLDRQGEYVARTDFLWKAKLKVEQEEVETMRGINKILLENILPAHVATHFLHLERSTELYHESYSCVAVMFASIPNYKEFYDETDVNKQGLECLRLLNEIICDFDKLLLKPKFSGIEKIKTIASTYMCASGLRPGKEDGATDEKRTEEHNVVILVEFAIALMSILDSINRESFQRFRLRIGLNHGPVIAGVIGAQKPQYDIWSNTVNVASRMDSCGVMGRLQTTENTAKILMTAGYECECRGLTYVKGKGNLVTYFVKTPFDGKL
What is the function of this protein?
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
What are the official names of this protein?
Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylyl cyclase 76E.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: MQNC_STRCO
Sequence: MTEKADLQPILDRAAAGGRITPEEALDLYRDAPLHALGAAADAVRRRRYAGTEHIATYIIERNINYTNVCVTACKFCAFYAAPKDTKKGWSRDLDDILRRCAETVELGGTQIMFQGGHHPDYGVEYYEEHFAAIKKEFPQLVIHSLGASEVEHMARISKVSVEEAIRRIHAAGLDSFAGAGAELLPERPRKAIAPLKESGERWLEIMEIAHGLGVESTSTMLMGTGETNAERIEHLRMIRDVQDRTGGFRAFIPYTYQPENNHLKGRTQATLFEYLRMIAIARVFLDNVAHIQGSWLTTGKEVGQLSLHYGADDLGSIMLEENVVSSAGAKHRSNRLEIIDLIRKAGRVPAQRATTYEHLVVHDDPANDPVDERVVSHISSTAIEGGTAHPELKLLAPN
What is the function of this protein?
Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
What are the official names of this protein?
Cyclic dehypoxanthine futalosine synthase, Cyclic DHFL synthase, Dehypoxanthine futalosine cyclase, DHFL cyclase, Menaquinone biosynthetic enzyme MqnC.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. MqnC family.