PharMolix/UniProtQA huggingface dataset:
Protein: AMER2_MOUSE
Sequence: METGRSRGGGAAVSERGGGARAGVCGRQEQAGALAADMDSHCECAAETPAAEPPSGKINKAAFKLFKKRKSGGTMPSIFGVKNKGDGKSSGPTGMVRSRTHDGLAEVLVLEGSKKEEPPGGSDHSGARPIPGPPKPSGPGLGSLASSSVAKSHSFFSLLKKNGRSETGKGDHAEASKAGGKQKRGLKGIFSSMRWHRRDKRGKEEEEKAVRAAGPGNLVLPGSLTASLECVKEEPPRAARRPDSPGQDASRHAAGEPAGGEQAPASAESAPERICLEAGSPTGSGDQSSRGEDAEGHRREEKPGAALESGAGEVQAAEDASKTGDVPIKTVPLVDSEGGSGRASAVPDPSSVDPPSDPSADRICLMFSDVTSLKSFDSLTGCGDIIADPEEEAGPSCDKHVPGPGKPVLSKKNASVVAYQGGGEEMASPDQVDDTYLPEFWDMLSQTEDQGQGTQEGAAKAATASDIKLAPETSSDTRCGEAAKDMSSVKRRRLHRIPIESQQKEEPKHPEKEHQEGVPNSDEGYWDSTTPGPEEESISNSSSSKKVVIPRDSDSGDALCDLYVEPEASPATLPATEDPPCLSRLKPVSPGTITCPLRTPGSLLKDSKIPISIKHLSNLPSSHPVVHQQPARSEVPRTKIPVSKVLVRRVSNRGLAGTTIRAAACHDSAKKL
What is the function of this protein?
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning.  Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity).
What are the official names of this protein?
APC membrane recruitment protein 2, Amer2, Protein FAM123A.
What is the protein family that this protein belongs to?
Belongs to the Amer family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Protein: RGRF2_RAT
Sequence: MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKAAEASRWHEKWFALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVLFGHEGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHTHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEGNPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDTSDDDTKGPGHMFGHLDFKIVVEPPDAAPFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSSLNSRIGALDLTTSSSSSSPTTTVHSPAASPPPHTAVPESAPADRAGDSTDMSPCRSPSTTPRHLRYRQPGGQVADSTHCAVSPASAFAIATAAAGHGSPPGFNNERTCDKEFIIRRTATNRVLNVLRHWVSKHSQDFELNNELKMNVLNLLEEVLRDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWTKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDTLYELSLKIEPRLPA
What is the function of this protein?
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP.  Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation.  Functions in synaptic plasticity by contributing to the induction of long term potentiation.
What are the official names of this protein?
Ras-specific guanine nucleotide-releasing factor 2, Ras-GRF2, Ras guanine nucleotide exchange factor 2.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated (By similarity). Found both at cell periphery and along the axon of neurons.
Protein: UTP15_YEAST
Sequence: MSTARPRIITSKAPLLPQQTTPEQRYWRQYTSAQLVKEHNSVTHISFNPQHPHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYDSYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVRTLSFIPAAPHLVATGSYDGLIRLYDTRSSGSTPIYSLNHDQPVENVIAVSPTQIVSCGGNNFKVWDLTSNKKLYERGNFNKAVTCLDYVENFDSPMQSALIASSLDGHVKVFDPLDNFQVKFGWKFSGPVLSCAVSPSTAQGNRHLVAGLSSGLLAIRTKKKEKRSSDKENAPASFNKNAKSNNFQRMMRGSEYQGDQEHIIHNDKVRSQRRMRAFERNINQFKWSEALDNAFVPGMAKELTLTVLQELRKRGKVRVALYGRDESTLEPLLNWCLKGIEDVRSASIVADWVAVVLELYGNTLESSPVLQELMIDLKTKVRHEIHKSKEAQRIEGMLQLLTS
What is the function of this protein?
Involved in nucleolar processing of pre-18S ribosomal RNA.  Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 15, U3 snoRNA-associated protein 15, U three protein 15, U3 protein 15 required for transcription, t-UTP15.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Note=Associated with ribosomal chromatin, even in the absence of transcription.
Protein: NUSB_BACCN
Sequence: MKRRTARERAMQALYQMDITGELNPKVAVENTLDEGEETNEFLDSLVGGFVEHKETIDELIRQNLKKWKLERISIVDRSILRLAVYEMKYMEEIPHNVTINEAIEIAKTFGDEESRRFINGVLSNIKDTL
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: SFTPD_HUMAN
Sequence: MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVESGLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGREGPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLPDVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF
What is the function of this protein?
Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins.  Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response.  May participate in the extracellular reorganization or turnover of pulmonary surfactant.  Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
What are the official names of this protein?
Pulmonary surfactant-associated protein D, PSP-D, SP-D, Collectin-7, Lung surfactant protein D.
What is the protein family that this protein belongs to?
Belongs to the SFTPD family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Protein: ZNT10_MOUSE
Sequence: MGRYSGKTCRLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLGSGYIARRGPRGSSATYGYVRAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGALGLAVNVVGLLIFQDCGACFSRCTRGRRTRPSQQPSQGDPRGALGCPQEAATATAPGSGTAVTLRGSSAGRKQQEGATVFSNVAGDSLNTENEPEETTKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVQPLRREDPCNWQCYIDPSLTVVMVIIILSSAFPLIKETAVILLQMVPKGVNMEELMSQLSTVPGISSVHEVHIWELISGKIIATLHIKHQKGTEYQDASRKIREIFHHAGIHNVTIQFETLDLKEALEQKDFLLTCSAPCITQSCAKKLCCPPGTLPLALVNGCAEHNGRSSRESYRSIEAPEVAIDVDGCPREQGQTLSKTQERQHYENSTHF
What is the function of this protein?
Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange.  Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.  Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis (PubMed:28461334).  Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (By similarity).
What are the official names of this protein?
Calcium/manganese antiporter SLC30A10, Solute carrier family 30 member 10.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network. Recycling endosome. Early endosome. Note=Relocalized from the trans-Golgi network to the plasma membrane upon elevated extracellular Zn concentrations.
Protein: UBP10_MOUSE
Sequence: MALHNPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTLCSIQAEDELPDGQEHQRIEFGVDEVIEPSEGLPPTPSYSISSTLNPQAPEFILGCTTSKKIPEAVEKDETYSSIDQYPASALALESNSNAEAETLENDSGAGGLGQRERKKKKKRPPGYYSYLKDGGEDSASPATLVNGHATSVGTSGEAVEDAEFMDVLPPVMPRTCDSPQNPVDFISGPVPDSPFPRTLGGDARTAGLCEGCHEADFEQPCLPADSLLRTAGTQPYVGTDTTENFAVANGKILESPGEDTAANGAELHTDEGADLDPAKPESQSPPAESALSASGAIPISQPAKSWASLFHDSKPSASSPMAYVETKCSPPVPSPLASEKQMEVKEGLVPVSEDPVAIKIAELLETVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVIKSSLSEKGRQEDAEEYLGFILNGLHEEMLSLKKLLSPTHEKHSVSNGPRSDLIEDEELEDTGKGSEDEWEQVGPKNKTSITRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQLFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEVSRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLVKNIDYPVDLEISRELLSPGIKNKNFKCQRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKPPADRTAYLLYYRRVDLL
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR.  Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53.  Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response.  Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes.  In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13.  Does not deubiquitinate MDM2.  Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.  Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage.  Deubiquitinates TBX21 leading to its stabilization.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 10, Deubiquitinating enzyme 10, Ubiquitin thioesterase 10, Ubiquitin-specific-processing protease 10.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP10 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions (By similarity). After DNA damage, translocates to the nucleus following phosphorylation by ATM (By similarity).
Protein: GBLP_TOBAC
Sequence: MSQESLVLRGTMRAHTDWVTAIATAVDNSDMIVTSSRDKSIIVWSITKDGPQYGVPRRRLTGHGHFVQDVVLSSDGMFALSGSWDGELRLWDLQAGTTARRFVGHTKDVLSVAFSVDNRQIVSASRDKSIRLWNTLGECKYTIQDGDSHSDWVSCVRFSPNNLQPTIVSGSWDRTVKIWNLTNCKLRLTLAGHTGYVNTPAVSPDGSLCASGGKDGVILLWDLAEGKKLYSLESGSIIHSLCFSPNRYWLCAATESSIKIWDLESKSIVDDLKVDLKQESEMSSEGTASGKNKVIYCTSLSWSADGSTLFSGYTDGLIRVWGIDRY
What is the function of this protein?
May have a role in cell division.
What are the official names of this protein?
Guanine nucleotide-binding protein subunit beta-like protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
Protein: YBEY_SALEP
Sequence: MSQVILDLQLACENHAGLPDEAQFQRWLDGVIPQFQEEAEVTIRLVDETESHDLNLTYRGKDKPTNVLSFPFEAPPGIEMPLLGDLIICRQVVEQEAQEQSKPLEAHWAHMVVHGSLHLLGYDHIDDDEAEEMESLETEIMLAMGYEDPYIAEKIAE
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK14_FAGEA
Sequence: MIQPQTYLNVADNSGARELMCIRIIGASNRRYAHIGDIIVAVIKEAIPNMPLERSEVIRAVIVRTRKELKRENGMIIRYDDNAAVIIDQKGNPKGTRVFGAIARELRQLNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EX7L_ECOHS
Sequence: MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSARQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLERLKKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAEILRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGNVLKKVKQVKAGEMLTTRLEDGWIESEVKNIQPVKKSRKKVH
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_METLZ
Sequence: MDLTINEKRVLAALIGSGPKAAEILAEKMDAALESVIQWAHLCADKGLVTLEKTVTEQAKLTEEGEKYAKEGLPERQILNSIDGSIPMSELTKNPLSKIAIGWLRKKNWVTIKDGIVFVNENTAVGEDELALKNPVPGTPACKELAKRGLVEVVEKTSWKIALTTDGEKIAKDGLDLREEVATLTREQILSGEWKSLPLRKYSIDKLPKKIYGGRVHPNQQILDEIRDLLFEMGFTEFHGSIVQNSFWNFDSLYQPQDHPAREMQDTFHLAEELPLPNGWEKIRDIHKFGGDTGSTGWGGEWSPEVGKKCVLRTHSTSLSIQYLAEHPNPPLKAFSISRVYRRETIDPTHLPEFEQLEGIVMDKDLHFGHLLGFFKEFFGRMGFEEVRFRPGYFPYTEPSVEPEVWVDGLGWVELGGAGIFRKEVTAPWGIDCPVLAWGLGVSRVSMLRMGLKDLRQLYKSDIDWIRASPVRRS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: QUEF_ANAD2
Sequence: MPTQPSRDLQTFPNPKPGRPFEIAMECPEFTCVCPMTGQPDFATIRLRYVPAERCVELKSLKLYLWSFRNEGTFHEAVTNRICDDLVAALAPRWIEVVGDFAVRGGIHTVVTARHGERPAGV
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
What are the official names of this protein?
NADPH-dependent 7-cyano-7-deazaguanine reductase, 7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBB_SHIDS
Sequence: MLRFLNQCSQGRGAWLLMAFTALALELTALWFQHVMLLKPCVLCIYERCALFGVLGAALIGAIAPKTPLRYVAMVIWLYSAFRGVQLTYEHTMLQLYPSPFATCDFMVRFPEWLPLDKWVPQVFVASGDCAERQWDFLGLEMPQWLLGIFIAYLIVAVLVVISQPFKAKKRDLFGR
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein.
What are the official names of this protein?
Disulfide bond formation protein B, Disulfide oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TRUA_THENN
Sequence: MRRVAAIVEYDGSNFFGYQGQPDVRTVQGVIEDALERIFKQRIYTQAAGRTDAGVHANGQLIAFNCPNDRMTTEDIKNAMNANLPDDVYVKKVFEVPKNFHPRFDVKKRIYHYFIHTSREKNVFLRKYAWWFPYELDLEAMRKAAKYLEGTHDFTSFKTGSDERDPVRTIYRIRILSLGKDMILIRVEGRSFLRRMVRNIVAALVKVGLRQWEPEKLKEVLEARDRSAAAGTAPAHGLYFYKVLF
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: PLPL_CRYNJ
Sequence: MPPSPPSSAAADQWNIDYVNEDSPLSPRSFSLPPESPQLSTASPIHQRVSRKRQRATSQGLTYNVIRWPLLFFIFFIIYLEFSAYVITRQIVNIFEWLVAWRGYKAKLRKELRKAKTYDEWVNTAKKLDKHLGFDDWKDVEEDSYFDWALVRRVRRTLTRLRAANDTRGLMDALAVCVRANFAGTESVKMYSETFIGTKKAVEAHIKEVAACLDYVRTATDVSLEEKRAFFRAVNKHYGSSALCLSGGASFGYYHFGVIKAFLEADLLPRVITGTSAGGLCAALLCTRTDSELKELLVPELADKITACSDPFTVWFKRFRQTGARFDTIDWARRSMWFTRGSLTFKEAYTKTGRALNISVVPSDRHSPTILLNHLTAPNCLIWSAILASAAVPGILNPVVLMAKDRSGNIKPHNLGGSRFKDGSLREDIPLGSLHTQFNCNFSIVSQTNPHIHLFFFAPRGSVGRPVAHRKGKGWRGGFILSALESYIKLDLSKHFKVIRDLDLMPQILQSDWSGVFLQRFSGDLTLTPRSTIGDWFHILSDPDRPQMKRMLRVGERVAWPALGMVRNRMTVERAILRGRSEVRTALSHDRTSNDPATSLPETNPELTGALDHVPIESDVDAGFVSRSRRARNKTGSKGGDTPEEQLNLAGVFQLDESSKGVRRRKQKKSGMPLVAEPLGELPEVSPTHSPIATESPQRNYTSNFGDSFRHVRAPSLPALSSPFRSIRSNTSSSSNNVQSPSSSQRFRSQLSITRWFGGVSESSSDEEDEDLGGLQSGEATASSGEEGIPTFQLDSAVESHSDRSEDEMLHSGANVKEEYQSEESEGKIPIPGGERVTQEKIDSSMASGERLRPAGGSKGSAKTPPVQDGA
What is the function of this protein?
Probable lipid hydrolase.
What are the official names of this protein?
Patatin-like phospholipase domain-containing protein CNE02340.
What is the protein family that this protein belongs to?
Belongs to the PLPL family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RSXA_SALPK
Sequence: MTDYLLLFVGTVLVNNFVLVKFLGLCPFMGVSKKLETAMGMGLATTFVMTLASICAWLIDTWILIPLDLIYLRTLAFILVIAVVVQFTEMVVRKTSPALYRLLGIFLPLITTNCAVLGVALLNINLGHHFLQSALYGFSAAVGFSLVMVLFAAIRERLAVADVPAPFRGNAIALITAGLMSLAFMGFSGLVKL
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.  Required to maintain the reduced state of SoxR.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit A, Rsx electron transport complex subunit A.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RLPA_SALTI
Sequence: MHKQLPVICVAAGIVLLAACTNDGGQQQTTVAPQPAVCNGPTVEISGAEPRYEPLNPTANQDYQRDGKSYKIVQDPSRFSQAGLAAIYDAEPGSNLTASGEMFDPMQLTAAHPTLPIPSYARITNLANGRMIVVRINDRGLYGTDRVISLSRAAADRLNTSNNTKVRIDPIIVAPDGSLSGPGMACTTVAKQTYALPPRPDLSGGMGSASSAPAQPQGDVLPVSNSTLKSDDTTGAPVSSSGFLGAPTTLAPGVLEGNEPTPAPQTAPVSAPVTAPATATPVSAPAAAAPVSAPVSAPAAAASGRFVVQVGAVSDQTRAQQYQQRLSQQFSVPGRVIQNGAVWRIQLGPFASKAEASALQQRLQTEAQLQSFIASAQ
What is the function of this protein?
Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
What are the official names of this protein?
Endolytic peptidoglycan transglycosylase RlpA, Rare lipoprotein A.
What is the protein family that this protein belongs to?
Belongs to the RlpA family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: ACT1_DAUCA
Sequence: MADGEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGIITLKYPIEHGIVSNWDDMRIWHHTFYNELRASPEEHPVLLTEAPLNPKANREKMTQIMIETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDGLMKILTEKSICHYTTAEREIVRDMKEKLAYVALDYEQELETAKRRSAVEKNYELPDGQVITIGAERFRCPQVLFQPSMIGMESAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGSTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSDLWIGGSILASLSTFQQMWISKGEYDESGPSIVHRKCLLAG
What is the function of this protein?
Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth.
What are the official names of this protein?
Actin-1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PPME1_BOVIN
Sequence: MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVRNSEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQ
What is the function of this protein?
Demethylates proteins that have been reversibly carboxymethylated.  Demethylates PPP2CB (in vitro) and PPP2CA.  Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity).
What are the official names of this protein?
Protein phosphatase methylesterase 1, PME-1.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: PSTB_SYNP6
Sequence: MSPTAGENILLKAEALSVYYGNSLAVKDVYLEVLKNKIVAFIGPSGCGKSTILRCFNRMNDLINGCRVQGRITFHDQEINDGRVDAVELRSRIGMVFQKPNPFPKSIYENIAYGARINGYQGDMDELVEKSLRQAALWDEVKDKLKDSGLALSGGQQQRLCIARTVAVQPEVILMDEPCSALDPISTLAIEELMQTLKEQYTIIIVTHNMQQASRTSDYTAFFNARATEGGGKMGYLVEFDTTEKIFDSPDQEATADYVSGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: THIC_PROM9
Sequence: MRSSWIKPRLGKDNVTQINFARNGYITEEMDFVAKKENLPASLIMEEVARGRLIIPANINHLNLEPMSIGIASRCKVNANIGASPNASDINEEVEKLKLAVKYGADTVMDLSTGGVNLDEVRKAIIHESPVPIGTVPVYQALESVHGSIDRLTEDDFLHIIEKHCQQGVDYQTIHAGLLIEHLPKVKGRITGIVSRGGGILAQWMLHHFKQNPLYTRFDDICEIFKKYDCTFSLGDSLRPGCLHDASDDAQLAELKTLGELTRRAWEHNVQVMVEGPGHVPMDQIEFNVRKQMEECSEAPFYVLGPLVTDISPGYDHISSAIGAAMAGWYGTSMLCYVTPKEHLGLPNAEDVREGLIAYKIAAHAADIARHRAGARDRDDELSHARYNFDWNKQFELSLDPERAKQYHDETLPEEIFKKAEFCSMCGPKHCPMNSKISDESLDQLKDKLEECNSSV
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: DENR_NEUCR
Sequence: MTALTGRPVVYCGVCSLPPEYCEYGGTVKKCQQWLEKNQPTMYSRIWSPEVLEAEMASLSVEAQERAMKDAKKKAAKAEAAEQKQADKRANSVVTIKRIERNKRKYVTSVSGLEAFGLELKKVAKDFGKKFATGSSVTKVPSGGEEIVVQGDVSGEIEEFILEKYKEVPEDNIELVEDKKKKKGEGN
What are the official names of this protein?
Translation machinery-associated protein 22.
What is the protein family that this protein belongs to?
Belongs to the DENR family.
What are the subcellular locations of this protein?
Cytoplasm.