PharMolix/UniProtQA huggingface dataset:
Protein: LGT_BARHE
Sequence: MNDFSCPAIAFPSFLNPVIVHLGPIALYWYGLGYVVGILFVWWYAQKLLKKQSLWYANHPPMDKEKIGDFVVWSAISIVVGGRLGQVLVWDPIYYFSHPTAIITIWNGGMSFHGGLIGITIAMIWFARKNNIKIRAMFDIIAIGAPIGIGIVRICNFINQELWGNVTTHPWAVCFPLDPYYLPRHPSQLYEALMEGFLLFVILFILTFAFKALKRPGTVSGIFIIGYAIARSISEIYRAPQEDPEWFSTLFHSTGFTYGMALSLPMLFLGFYLLFQAFKDESTKNGHTQTKN
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MSH_PAPSO
Sequence: MRTESIKTNRPMDLLLQYLQPISVALVVIALVWNYGRRNPTKKLAPEASGGRPIMGHLHLFNDGELTHRKLGAMADTYGPVFNIRFGSHKTLVVSDWEIVKECFTTNDKLFSNRPGTLGIKLMFYDADSVGYAPYGAYWRDLRKISTLKLLSNHRIDTIKHLRSSEVESCFESLYSQWGNGEKSGEFAPVRMDSWLGDLTFNVVARIVAGKKNFSANGDVGAQRYKAAMDEAMRLMRFFAFSDVIPSLSWLDNLRGLVREMKKCASEIDSIMATWVEEHRVKRNSGGNSQLEHDFIDVCLDIMEHSSLPGDDPDLVVKSTCLDMILGGSDTTTVTLTWAMSLLLNHPQVLQKAKEELETQVGKNRQVDDSDIPNLPFIQAIIKETMRLYPAGPLIERRTMEDCEVAGYQVPAGTRLLVNVWKMQRDGNVYKGDPLEFRPDRFLTSNADVDLKGQHYELIPFGAGRRICPGVSFAVQLMHLVLARLLHEFEITTVEPETKVDMAESGGLLCYKIMPLEVLIKPRLEI
What is the function of this protein?
Catalyzes the conversion of N-methylated protoberberine alkaloids N-methylstylopine and N-methylcanadine into protopine and allocryptopine, respectively, in the biosynthesis of isoquinoline alkaloid sanguinarine.
What are the official names of this protein?
Methyltetrahydroprotoberberine 14-monooxygenase, (S)-cis-N-methylstylopine 14-hydroxylase, (S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase, Methyltetrahydroprotoberberine 14-hydroxylase, N-methylstylopine hydroxylase, MSH.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: IF2_PHOLL
Sequence: MTDVTVKSLAEEIQTSVDRLVQQFADAGIKKTETDFVSQKEKEALLAHLNREQGGSAGKPDKLTLQRKTRSTLNVSGTDGKSKPVAVEVRKKRTYVNRDAVEQAKAEEQAKREAEEQARREAEEKAQREAEAAAKKLVEEQAKREAEEKAKREAAEKAKRQAAESEKVTNQHTEHKQKPAQTDKTIQSEKARREAEAADLKRKAEEEMRRKVEEEAKRVAEEARRMAEENQDKWSSDSDSIDSDDYHVTTSRHARAAEDENDAKVEGDRRARGRSGKATRQKKNNKHSESKADREEARAVGRTKGKQRKTSTLQQSFNKPVAAVNRDVVIGETITVAELANKMAVKGSQVIKAMMKMGAMATINQVIDQETAQLVAEEMGHKVILRRENELEEALMSDRDTGEAVAEPRAPVVTIMGHVDHGKTSLLDYIRSTKVASGEAGGITQHIGAYHVETDSGMITFLDTPGHAAFTSMRARGAKATDIVVLVVAADDGVMPQTIEAIQHAKAASVPVVVAVNKIDKPEADPDRVKSELSQHGVQPEEWGGETQFINVSAKAGIGIDELLDAILLQAEVLELKAVRSGMASGVVIESFLDKGRGPVATVLVQEGTLNKGDIVLCGFEYGRVRAMRDELGREVFSAGPSIPVEILGLSNVPAAGDEATVVRDEKKAREVALYRQGKFREVKLARQQKSKLENMFANMEEGEVSELNIVLKSDVQGSCEAIREALEQLSTDEVKVKIIGSGVGGITETDATLAAASNAIILGFNVRADASARRVVENESLDLRYYSVIYSLIDEVKQAMSGMLAPEYKQQIMGLAEVRDVFKSPKFGAIAGCMVTEGTIKRNNPIRVLRDNVVIYEGELESLRRFKDDVNEVRNGMECGIGVKNYNDVRVGDMIEVFEIIEVKRSIA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPE_STRAW
Sequence: MAAELHVELVAADRQVWSGEATLVVARTTSGDIGVMPGHQPLLGVLESGPVTIRTSDGETVVAAVHGGFISFADNKLSLLAEIAELADEIDAQRAERELERAKAEGDATAERRADVRLRAVSAR
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: NRDR_EHRCR
Sequence: MKCPFCNSTDTQVKDSRSIENDMLIRRRRVCLVCHSRFTTTEKLLLRSFMVVKKNGETELFNKQKLLSSILIATKKRPVSHEGINMMVNNIFYELEGKKENAIPTNVIGKMVMDNLFKLDKVAYVRFASVYMNFRNINDFSNIIAKIISEKTP
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: ARMH4_ARMME
Sequence: MSSLLPPHAQILVVGGGPAGSYCASILAREGFSVVVLEATTFPRYHIGESMLPSVRPFLKFSGADNKIASHGFCPKPGAAVKFQQHKREGYTDFSTLSSGNSPDNAAAWNVKRSEFDEILLRHAEELGAQVFENHRVINLIFADNNVSEGRPISAEFSCPNGELRSISFDYLVDASGRAGIMSTKYLKNRKFNNTLRNVASWGYWTGAKRYMPGSERDNAPFFEALTDGSGWAWFIPLHDSTVSVGIVTDQASSTARKALSARNGMHCSSKADYLAQLKLAPTVSGKFLCKATLQGENSPTCIRSASDFSYAADRYSGDHFRLIGDASAFIDPFFSSGVHLALLGALTAAASISASIRKTCSELRAAQFHDKKVAIAYTRFLLVVMGVYKQIRNQDLHILAEVDEDNFDRAFDILRPVIQGTADVGKTVSEDELQKTMDFCKDIFAPTDPQMHEAVGARLGPELCSPSVPIMTDSEIEDLTKDDNEAKLVLKEINARKAVHTMYGGPIHVAAESIDGLVLNLEVGNFGLKNVH
What is the function of this protein?
Flavin-dependent halogenase involved in the biosynthesis of melleolides, a range of antifungal and phytotoxic polyketide derivatives composed of an orsellinic acid (OA) moiety esterified to various sesquiterpene alcohols.  The halogenase catalyzes the transfer of a single chlorine atom to the melleolide backbone, resulting in a 6'-chloromelleolide product.  The enzyme acts on free substrate and does not depend on carrier-protein-dependent acceptor molecules.  Can also catalyze the transfer of a single bromine atom to the melleolide backbone in vitro.
What are the official names of this protein?
Flavin-dependent halogenase armH4, ArmH4.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.
Protein: RIOX1_CHICK
Sequence: MAACGAEERQRTGRLSALSVYRRAAGPGRLERRRRGTPLPAGGKRTKARLRRGAAGGGGPERAAPPQGAAVSDRVERAGSSEAKQGDLKTNPSGPPAKAPAGNLETKSPGGPLTTSVGPRAKAPAGSPEAKPPGDPATSPGGGGVPGLLRRLGRLEDSRRRAAELFRWLVAPAAPEEFARQHWERAPLLVQRGDPGYYAGLFSTADFDAILRSGDVHFGTHLDVTSYAEGVRETHNPVGRALPAVVWDFYQNGCSLRLLSPQAFSTTVWHFLSILQEHFGSMAGANTYLTPPGTQGFAPHYDDIEAFVLQLEGKKHWRVYGPRTSSEALPQFSSANLTQAELGEPLLEVVLEAGDLLYFPRGFIHQADCLPDAHSLHITVSSYQRNSWGDFLEKLLPAALQMALEEDLEYRQGLPMDCLGYMGVANSDAVDARRTAFVEKVQHLIKKLVDYAPIDAAMDQRAKSFLHDCLPPVLTQSEKQLSVYGFPARWQDGGPRNVDIQITKDTEVRLLHHGVVRLCNEEAGVMLYYTTENSRVYHKEEPKYLEIDPEYTDSIEFLLSSYPNHVSVDTLPCDALEDKISLATLLFEKGILTTKKPLVQV
What is the function of this protein?
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity).  Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code.  Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2).  Also catalyzes demethylation of non-histone proteins (By similarity).  Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity).
What are the official names of this protein?
Ribosomal oxygenase 1, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, Histone lysine demethylase NO66.
What is the protein family that this protein belongs to?
Belongs to the ROX family. NO66 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm.
Protein: UBIB_BURM7
Sequence: MRIFRFVKIVFTVIRFGLDEVMLSRIENPRVKLLLRITTIGRRFADPPAVRLRRALESLGPIFVKFGQVLSTRRDLLPVDFANELAKLQDQVPPFDSAVAIAIVEKSLGARIDVLFDEFERVPVASASIAQVHFAKLKQGEHKGKAVAVKVLRPNMLPVIDSDLALMRDIATWAERLWADGRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDYSTPAVLVMERMTGVPISQVDTLRAAGVDIPKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPKHFGRYIALDFGIVGALSDFDKNYLAQNFLAFFKRDYHRVATLHLESGWVPPDTRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLVLLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTLPQLPRLVHQALISHHEAPRAISDDLIRQILVEQRRTNRLLQALLVFGLAVGAGAVIARVLIVLAYGG
What is the function of this protein?
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
What are the official names of this protein?
Probable protein kinase UbiB, Ubiquinone biosynthesis protein UbiB.
What is the protein family that this protein belongs to?
Belongs to the ABC1 family. UbiB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: TUSB_CROS8
Sequence: MLYTLSRSPWQVDIHALLRLVRSGDDILLMQNGVVAALHDSRYVAVLLASPARVVALENDVEARGLVAQISSSIDTISYTEFVNLTVKHASQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CH601_PARUW
Sequence: MAKLLQFNEEALKSILKGVKTLAKAVKVTLGPKGRNVVINKGFGSPLSTKDGVTVAKEVVLKDKFENMGAQLVNQVAAKTSDVAGDGTTTAIVLAEAIYSAGVKNVAAGANPMSLKRGIDQAVETITRSLDHLSTPVNTAQEVRQIATISANNDGEIGRIIGEAMERVGKDGIITVAEAKGIETHVDYVEGMQFDKGYVSPYFITNAEQMSVELSNADILITDKKLSAAKDIIPVLEKIMEKGARPLLIIAEDIDGEALATLVVNKLKAGMTVCAVKAPGFGDRRKAMLQDIAILTGGKVVSEEVGLKLDEVGPEVLGRAKTIKVSKEETTIIDGAGQSNEVKSRLAQIKAELANASTSKYDKEKLEERLAKMVGGVAVVNVGAATETELKEKKARVEDALHATRAAVAQGIVPGGGVALLRAVKSLEKLQLTGDEAIGVTIIKQAAFAPAIAIANNCGKQGNLIAEKIYEATGSYGYDGLTDEFKDLLKAGVIDPVLVTKSALINAASIAGLLLTTAAMITDKPQPKSQPAGMPGMDGMGGMGMGGMGGMGGMGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 1, 60 kDa chaperonin 1, Chaperonin-60 1, Cpn60 1.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_AFIC5
Sequence: MTEKKARPIKVVAENRKARFNYSIEDTFEAGVMLTGTEVKSARNGKSTISESYADSKNGEIWLVNANIPEYLQANRFNHEPRRPRKLLLHKRQINKLIGAIEREGMTLIPLKMYFNEQGRLKLELALAKGKKLHDKRETEKKRDWSREKSRLLRARG
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: COX1A_PARDE
Sequence: MSAQISDSIEEKRGFFTRWFMSTNHKDIGVLYLFTAGLAGLISVTLTVYMRMELQHPGVQYMCLEGMRLVADAAAECTPNAHLWNVVVTYHGILMMFFVVIPALFGGFGNYFMPLHIGAPDMAFPRLNNLSYWLYVCGVSLAIASLLSPGGSDQPGAGVGWVLYPPLSTTEAGYAMDLAIFAVHVSGATSILGAINIITTFLNMRAPGMTLFKVPLFAWAVFITAWMILLSLPVLAGGITMLLMDRNFGTQFFDPAGGGDPVLYQHILWFFGHPEVYMLILPGFGIISHVISTFARKPIFGYLPMVLAMAAIAFLGFIVWAHHMYTAGMSLTQQTYFQMATMTIAVPTGIKVFSWIATMWGGSIEFKTPMLWALAFLFTVGGVTGVVIAQGSLDRVYHDTYYIVAHFHYVMSLGALFAIFAGTYYWIGKMSGRQYPEWAGQLHFWMMFIGSNLIFFPQHFLGRQGMPRRYIDYPVEFSYWNNISSIGAYISFASFLFFIGIVFYTLFAGKPVNVPNYWNEHADTLEWTLPSPPPEHTFETLPKPEDWDRAQAHR
What is the function of this protein?
Subunit I and II form the functional core of the enzyme complex.  Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).  This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.
What are the official names of this protein?
Cytochrome c oxidase subunit 1-alpha, Cytochrome aa3 subunit 1-alpha, Cytochrome c oxidase polypeptide I-alpha.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TDH_ECOSE
Sequence: MKALSKLKAEEGIWMTDVPVPELGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVKGFKIGDRVSGEGHITCGHCRNCRGGRTHLCRNTIGVGVNRPGCFAEYLVIPAFNAFKIPDNISDDLASIFDPFGNAVHTALSFDLVGEDVLVSGAGPIGIMAAAVAKHVGARNVVITDVNEYRLELARKMGITRAVNVAKENLNDVMAELGMTEGFDVGLEMSGAPPAFRTMLDTMNHGGRIAMLGIPPSDMSIDWTKVIFKGLFIKGIYGREMFETWYKMAALIQSGLDLSPIITHRFSIDDFQKGFDAMRSGQSGKVILSWD
What is the function of this protein?
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
What are the official names of this protein?
L-threonine 3-dehydrogenase, TDH.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRP45_SCHPO
Sequence: MALLSEELSSILPNPDFDDEEEDYVERETSHADERQIGVKFHIPPYGQRKGWFPSSPEDFGDGGAFPEIHVAQYPLDMGRKRSAKSAGNTLALQVTSSGAVDYNAIARQGHEHGELVQASFRDLIPLRARLGVGEISLEKPSDEQKQEVANKTKLALQKILSKQIAQSQPKSAVVQQRDDPVYIRYTPSNQMGQALSKQRIIKMVTAEQDPMEPPKFRHKKVPRGPPSPPPPVLHSPPRKVSAQEQQDWQIPPSISNWKNPKGYTIPLDKRLAADGRGLNDVEINDGFAKFSEALYTVERQAREEVRYRAIMRQKMAEKEKQEKEQRLFMLAQKAREDRMGRNAASSGPSHAKPRSTSVSSEERSRSRAGSFSHHSESENEDEDSEAFRRRQELRRERRRQAEKDLRLSRMGAEKRAKLAEKDRPRDVAERVALGLSKPSMSSDTMIDSRLFNQASGLGSGFQDEDSYNVYDKPWRAAPSSTLYRPGATLSRQVDASAELERITSESRYDVLGNAHKKFKGSDEVVESRAGPVTFEKDIADPFGVDTFLNNVSSKKT
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-processing protein 45, Complexed with cdc5 protein 13, Transcriptional coregulator snw1.
What is the protein family that this protein belongs to?
Belongs to the SNW family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MIC10_MOUSE
Sequence: MSESELGRKWDRCMADTVVKLGTGFGLGIVFSLTFFKRRMWPLAFGSGVGLGMAYSNCQHDFQAPYLLHGKYVKEQ
What is the function of this protein?
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
What are the official names of this protein?
MICOS complex subunit Mic10, Mitochondrial inner membrane organizing system protein 1.
What is the protein family that this protein belongs to?
Belongs to the MICOS complex subunit Mic10 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein. Note=The C-terminus is located in the intermembrane space, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space.
Protein: PYRC_LISW6
Sequence: MYVLKNGQILNESGELENKDVLIQNGKVNLIADSIEVTSGEEFDATGKLIAPGFIDVHVHLREPGGEHKETILTGTKAAARGGYTTICSMPNTKPVPDSKEVMERLQAKIKETAEVRVLPYASITTSLGTDELVDFEALKEAGAFAFTDDGVGVQLAGTMYEAMKRAAALDMAIVAHCEDNSLIYGGVVHDGIFAEREGLKGIPNIAESVQIARDVLLAEAAGCHYHVCHISTKESVRVVRDAKRAGIRVTAEVSPHHLILDEEAIPGNDGQWKMNPPLRSKADRAALLEGLLDGTIDFIATDHAPHAAEEKNVPMEQAAFGIVGLETAFPLLYTHFVQTNEWTLKQLIDWMTVKPAECFKLPYGKLEEGTTADIVVLDLEKEATIDPDTFYSKGKNTPFVGETCIGWPVATFVEGTLVYKEGESK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
Protein: TBAB_SCHCO
Sequence: MREVISVHVGQAGVQIGNACWELYTLEHGLSPDGRLMDDSPSKHDSGSTFFSETGQGKHVPRRLYVDLEPGVIDDVKNGPYRSLFHPETMITGKEDAANNYARGHYTVGKELIDPVMDKLRRLADNCSGRQGLFVFHSFGGGTGSGFGALLLERLSTDYGKKAKLEFCVYPAPQLSSSVVEPYNSLLTTHTTLEHSDCSFMVDNEAIYDICKKNLGVAQPGFTNLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPFPRIHFPLASYAPLLSAPRRQHEQNSVEEMTFSCFESGNQMVKCDAKDGKYMACCLLYRGDVVPKDTQAAVASIKTKRTIQFVDWCPTGFKLGVCNEAPATVPGGDLAKVPRSLCMLSNTTAIAAAWNRLDYKFDLMYRKRAFVHWYVGEAMEEGEFSEAREDLAALEKDYEEVGTDSADAEEEGEY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-1B chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: VP1_POVBK
Sequence: MAPTKRKGECPGAAPKKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENDFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGEPLEMQGVLMNYRSKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENARYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVFDGTERLPGDPDMIRYIDKQGQLQTKML
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins.  Interacts with gangliosides GT1b and GD1b containing terminal alpha(2-8)-linked sialic acids on the cell surface to provide virion attachment to target cell.  This attachment induces virion internalization predominantly through caveolin-mediated endocytosis and traffics to the endoplasmic reticulum.  Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating.  Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal.  In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.
What are the official names of this protein?
Major capsid protein VP1, Major structural protein VP1.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses coat protein VP1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: TPC13_CAEEL
Sequence: MADNPASSSSQQLLALRVMRLARPKFAPVDGFSHDPVDPTGFGELLAGKVSEISKESRQDLPIGEYLIAPQMFENIYLGETFTFYVNVVNESEKTVSSVSLKCELQTSTQRVVLPCSVQDATIESSKCEGQVISHEVKEIGQHILICSVNYKTSNGENMYFRKFFKFPVSKPIDVKTKFYSAEDNANQDVYLEAQIENTSNANMFLEKVELDPSQHYNVTSIAHEDEFGDVGKLLKPKDIRQFLFCLTPADVHNTLGYKDLTSIGKLDMSWRTSMGEKGRLQTSALQRIAPGYGDVRLSVEKTPACVDVQKPFEVSCRLYNCSERALDLQLRLEQPSNRHLVFCSPSGVSLGQLPPSQHVDFSLNVFPVTVGIQSISGIRITDTFTKRIYEHDDIAQIFVS
What are the official names of this protein?
Probable trafficking protein particle complex subunit 13 homolog.
What is the protein family that this protein belongs to?
Belongs to the TRAPPC13 family.
Protein: GLMM_STRP4
Sequence: MGKYFGTDGVRGEANLELTPELAFKLGRFGGYVLSQHETEAPKVFVGRDTRISGEMLESALVAGLLSVGIHVYKLGVLATPAVAYLVETEGASAGVMIXASHNPALDNGIKFFGGDGFKLDDEKEAEIEALLDAEEDTLPXPSAEGLGILVDYPEGLRKYEGYLVSTGTPLDGMKVALDTANGAASTSARQIFADLGAQLTVIGETPDGLNINLNVGSTHPEALQEVVKESGSAIGLAFDGDSDRLIAVDENGDIVDGDKIMYIIGKYLSEKGQLAQNTIVTTVMSNLGFHKALNREGINKAVTAVGDRYVVEEMRKSGYNLGGEQSGHVILMDYNTTGDGQLSAVQLTKIMKETGKSLSELAAEVTIYPQKLVNIRVENVMKEKAMEVPAIKAIIEKMEEEMAGNGRILVRPSGTEPLLRVMAEAPTTEEVDYYVDTITDVVRAEIGID
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: RLMF_VIBCM
Sequence: MNTPLKPKHGQKTNRKPKANKPVVKKQQTKQPPTHKVQGEEVAAVKSGLHPRNRHRGQYDFPALIKVVPELQSHVMKNPKGQWTINFADPISVKLLNKALLVLHYGVTYWDIPEGFLCPPIPGRADYIHRVADLLLKGNPQLNHSQVRALDIGVGANCIYPIVGVTEYGWSWVGSDVDPVSIQQASLIVQSNSKLQGHIECRLQKNSQHIFNGIIGANERYTVTTCNPPFHASLADAQQGTQRKLTNLQANQRKKGRLATPTLSHSRLNFGGQKAELWCPGGEAAFIGKMAVESQQFAQQVLWFSTLISKGDNVRGMKKQLEKLGAQSIHVIEMAQGQKISRFIAWSFQNAEQRKLWWQAKC
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DHSL_NOSS1
Sequence: MAKHLGKKIAPIPMSTDISVVDLIDNYFTAYNSARLREASQLLACDILKDGVTVGVSLSGAMTPAGFGVSALAPLIRNGFIDWMISTGANLYHDMHYGLGFELFAGNPFLDDVKLREEGTIRIYDIIFGYDVLLETDAFIRKILQAEPFQKRMGTAEFHYLLGKYVREVEKQLGVKHSCLLATAYEYGVPIYTSSPGDSSIGMNVAALALEGSQLILDPAIDVNETAAIAYNAREGEGKSAAVILGGGSPKNFLLQTQPQIHEVLGLEERGHDFFVQFTDARPDTGGLSGATPAEAVSWGKIDPDELPSTIVCYTDSTIALPLVTAYVLNQCPPRPLKRLYDRREELYDKLRTDYLAAKDKPVEKVATNGEVATYPCGTPIRQ
What are the official names of this protein?
Deoxyhypusine synthase-like protein.
What is the protein family that this protein belongs to?
Belongs to the deoxyhypusine synthase family.
Protein: CTHL3_SHEEP
Sequence: METQMASPSLGRCSLWLLLLGLLLPSASAQALSYREAVLRAVGQLNEKSSEVNLYRLLELDPPPKDAEDQGARKPVSFRVKETVCPRMSQQPPEQCDFKENGLVKQCVGTVSLDTSNDEFDLNCNELQSVRRLRPRRPRLPRPRPRPRPRPRSLPLPRPQPRRIPRPILLPWRPPRPIPRPQPQPIPRWL
What is the function of this protein?
Exerts, in vitro, a potent antimicrobial activity.  Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms (By similarity).
What are the official names of this protein?
Cathelicidin-3, Bactenecin-7, Bac7, PR-59.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.