PharMolix/UniProtQA huggingface dataset:
Protein: RGRF2_HUMAN
Sequence: MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSCRPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQDGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPRLCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSPAADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNTERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA
What is the function of this protein?
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP.  Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation.  Functions in synaptic plasticity by contributing to the induction of long term potentiation.
What are the official names of this protein?
Ras-specific guanine nucleotide-releasing factor 2, Ras-GRF2, Ras guanine nucleotide exchange factor 2.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity).
Protein: RS3A_PERAM
Sequence: MAVGKNKGLSKGGKKGVKKKIVDPFTRKDWYDVKAPSMFATRQIGKTLVNRTQGTKIASEGLKYRVFEVSLADLQNDNDAERSFRKFRLIAEDVQGRNVLTNFHGMDLTTDKLRSMVKKWQTLIEANVDVKTTDGYLLRVFCIGFTNKDQMSQRKTCYAQHTQVRAIRKKMVEIITRDVTSSDLKEVVNKLLPDSIAKDIEKACQGIYPLHDVYIRKVKVLKKPRFELSKLLELHGDGKGGSDEPGARVDRPEGYEPPVQETV
What are the official names of this protein?
40S ribosomal protein S3a.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VG20_BPML5
Sequence: MSLLDTGARYQTCIVYPEEMVIDSDGNKRTRPSNTGIPAIARFQVANQSGTSARRAEQDNEGFETEKVYRMRFPRSFTKEHGILGAQSQIEWRDQRWALFGDATVYDSSPALARVDYTIKRY
What are the official names of this protein?
Gene 20 protein, Gp20.
Protein: PEPVL_STAEQ
Sequence: MWKEKVLEYENQMIEDLKGLLSIESIRDDSKATADAPVGPGPREALDYMYNLGKRDGFSTHDVDHIAGRIEAGKGEDVLGILCHVDVVPAGDGWDSNPFQPVVTDNAIIARGTLDDKGPTIAAYYAVKILNEMKVDWKKRIHIIIGTDEESDWKCTDRYFKTEEMPALGFAPDAEFPAIHGEKGITTFDLVQNEVTEDTDEPDYELLKFESGQRYNMVPDYAKAEVLVKENMTDVIQNFENFLQQNQLQGESTVDSGILILTIEGKAVHGMDPSLGVNAGLFLLKFLASLNLNKSAKDFVEFNERYLFESHFGEKMGMKFHTDIMGDVTTNIGVISYDKEKAGRYGINLRYPEGFKFEDAIDRFRSEINELGFNLELGKVQKPHYVDKNDPFVKTLVNAYRNQTGDMTEPYTIGGGTYARNLDKGVAFGAMFADSEDLMHQKNEYITKKQLINATSIYLEAIYALCVED
What are the official names of this protein?
Putative dipeptidase SERP1310.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: CTND1_HUMAN
Sequence: MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI
What is the function of this protein?
Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349).  Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349).  Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476).
What are the official names of this protein?
Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120(ctn), p120(cas).
What is the protein family that this protein belongs to?
Belongs to the beta-catenin family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell- cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187). SUBCELLULAR LOCATION: [Isoform 1A]: Nucleus. SUBCELLULAR LOCATION: [Isoform 2A]: Nucleus. SUBCELLULAR LOCATION: [Isoform 3A]: Nucleus.
Protein: ISPH_CAMJE
Sequence: MIIELAKNYGFCFGVKRAIKKAEQIKDAATIGPLIHNNEEISRLQKNFNVKTLENIQALSNEKKAIIRTHGITKQDLEELRKKDIEIFDATCPFVTKPQQICEQMSKEGYEVVIFGDENHPEVKGVKSYVSTKAYVVLDKKELQNIKLPNKIAVVSQTTKKPEHFMEIVNFLILKTKEVRVFNTICDATFKNQDAIKELSLKSDVMVVVGGKNSANTKQLFLIAKTNCEDSYLIETEEELKKEWFLDKKHCGISAGASTPDWIIQKVIAKIENFRIN
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: OBG_HISS2
Sequence: MKFIDEALIRIEAGDGGNGCVSFRREKFIPKGGPDGGDGGDGGDVYLIADENLNTLIDYRFEKSFAAERGENGRSSDCTGRRGKDITLRVPVGTRAIDNDTKEVLGDLTKHGTKMLVAKGGYHGLGNARFKSSVNRAPRQKTNGTPGEKRDLQLELMLLADVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVTRVDTSRSFVIADIPGLIEGASEGAGLGVRFLKHLERCHVLIHLVDIAPIDESDPADNIAIIEGELFQYSEKLANKPRWLVFNKIDILSDEEATARAKNIMQRLGGEDDYYLISAATGKNVDVLCRDIMDFIEENPRQEQEKIDAQEVKFKWDDYHQEQLSEQVFTEDDQEEDDWDDWSEDDEEGVEIIYKP
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL33_RICFE
Sequence: MAKKNKNVLVRLVSTAGTGVFWVKKRNPKTQTEKLSFRKYDKVVRKHVLFKEEKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: TM9S4_HUMAN
Sequence: MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSLLYFGYTALMVLSFWLLTGTIGFYAAYMFVRKIYAAVKID
What is the function of this protein?
Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474).  Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576).  Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).
What are the official names of this protein?
Transmembrane 9 superfamily member 4, Tumor cannibalism associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein. Golgi apparatus. Early endosome.
Protein: NUOC_AGRVS
Sequence: MSEALQVLASHITENSGGLALSSTVAFGELTVTTTVENIYALVTFLRDDARCGFINIIDICGVDYPERVERFEVVYHFLAPKQNQRIRVKLSTSEDKPVPSICPLFPGADWFEREAWDLYGVMFTGHPDLRRLLTDYGFEGHPLRKDFPLTGFVEVRYDDTVKRVVYEPVELKQEFRSFDFLSPWEGTDYVLPGDEKAAK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACCA_RUBXD
Sequence: MLDFERPIKELEERIAELHRLAGESEGLQAEISRLEEALEAARRRIYTNLSPYQRVQVARHPERPNFRAYRDALCEDFYELSGDRHYGDDAAVRGGFARIRGRNVVLIGHDKGADVKSRVEGNFGMAHPEGYRKVKRLYGLAARFGLPVVTLVDTPGAFAGRGAEERGQAWAISEDLMALAAVPVPVVSVIIGEGGSGGALAMCLADYLGMLENSYLSVIAPEACASIIFRDSSRAPEAAEALKLTARDLKEHGVVDEVLPEPLGGAHRDPEAAIRAVGEALERVLAGVSGSSPEDLLKRRYARYRRIGSYQRLPGPSSG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYV_LACCA
Sequence: MEPVSDETLAPKYDHKAVEEGRYQEWLDEDVFKPSGDKKAKPYSIVIPPPNVTGKLHMGHAWDTTLQDIVIRQKRIEGFDTLWLPGMDHAGIATQAKVEAKLRKEGISRYDLGREKFVQKVWEWKDEFAKTIHGQWAKMGLSLDYSRERFTLDKGLNQAVRRVFVDLYNQGLIYRGEYIVNWDPQARTALSDIEVIHKDDKGAFYHVKYPFADGSGYIEIATTRPETMMGDTAVAVHPGDERYKDMVGTELILPLANRKIPIIEDAYVDPEFGTGAVKITPAHDPNDFQVGNRHDLKRINTMNDDGTMNENAGKYQGMDRFEARKAMVADLDKAGLLLKVEPIVHSVGHSERTGVQVEARLSTQWFVKMKPLAEAAIKAQQEPDKKVTFVPERFEHTYLQWMENIHDWVISRQLWWGHQIPAWYNKQTGETYVGMEAPKDIENWKQDPDVLDTWFSSALWPFSTMGWPNTDAPDYKRYYPTDTLVTGYDIIPFWVARMIFQGLHFTHQRPFQYTLIHGLMRDEQGRKMSKSLGNGIDPMDVIEKYGADALRWFLITGNKPGQDTRFSYKQVEAAWNFINKIWNISRFVMMNLGDLDTPQQPDPSTFDLSDKWLFAQLNETIKQVMDLSARFEFGEMGRTLYNFTWNVLADWYVEMSKEVLYGDDEQAKAAKRVNLAYALDQILRLLHPVMPFVHGKLWLALPHTGKSIVTASYPVANTAFENADATSAMDAIIALIRGVRGIRKEAGAPLKTKVDILVKLTDPALKPIFEQNFDFIDRFVNSKAFTVGTDVAEPKMAGSAVITGATIFVPLNELIDLDEEKAKLTKDAKKLEQEIARIDKKLNNQGFLSKAPEAVVAEQRTKRSDFEDQLTSTKQRLEQLQRA
What is the function of this protein?
Catalyzes the attachment of valine to tRNA(Val).  As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
What are the official names of this protein?
Valine--tRNA ligase, Valyl-tRNA synthetase, ValRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYR1_SYNY3
Sequence: MAITTAASRLGVAPYNESRPVELRPDFSLDDAKMVIRAVYRQVLGNDYIMDSERLKGAESLLTNGSISVREFVRTVAKSELYKKKFLYNNFQTRVIELNYKHLLGRAPFSEDEVIFHLDLYENQGFDADIDSYIDSVEYQENFGENIVPYYRFNNQVGDRTVGFTRMFRLYRGYANSDRSQLERSSSRLATELGQNTVSAIVGPSGSNAGWAYRPSRAGNTPAKALGGTVPFGQASKLFRVEITAISAPGYPKVRRSNKAVIVPFEQLNQTLQQINRLGGKVASITPASLS
What is the function of this protein?
Rod linker protein, connecting hexameric phycocyanin (PC, made by cpcA and cpcB) rods in the phycobilisome (PBS).  PC is the major phycobiliprotein in PBS rods.  Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.
What are the official names of this protein?
Phycobilisome 32.1 kDa linker polypeptide, phycocyanin-associated, rod 1.
What is the protein family that this protein belongs to?
Belongs to the phycobilisome linker protein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=This protein occurs in the rod, it is associated with phycocyanin.
Protein: WNT2_CAEEL
Sequence: MIPRRSCWLILLLNLLNVQSLLDASWWSTVAQLSTALAGHNVKPVCELPGLSPGQAQVCELFKDHMPAVSIGAQNAIQECQRQFTGHRWNCSTHYSTGMLGPIHKMATREAAFTYAILSAGVTHEIGRRCKQGLLTSCGCSDETKPKNVPTDWSWGGCGDNVEYGYKFSRDFIDIREKEHDPKRNHDNGRSLMNRRNNEAGRKILKRHRKPKCKCHGVSGACNMKTCWMQLPSMEQVGKILRNKYDKAIRVQINDRGNLQLLADEATKERKTRALPTDLVFMDDSPDYCRFDRHSGTLGTEGRVCKRGSGGAEGCDSLCCGRGYNTYTQEVKSKCNCKFEWCCKVVCQTCNNVTQVDICK
What is the function of this protein?
Ligand for members of the frizzled family of seven transmembrane receptors.  Probable developmental protein.  May be a signaling molecule which affects the development of discrete regions of tissues.  Is likely to signal over only few cell diameters.  Involved in the correct positioning of the developing nerve ring and in axon guidance of SIA and SIB neurons, probably by binding to tyrosine kinase receptor cam-1 (PubMed:19855022).  In addition, regulates the positioning of some head neuronal cells, muscle arms associated with the nerve ring and the excretory pore (PubMed:19855022).  Together with Wnt ligand cwn-1, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons (PubMed:16109397, PubMed:16516839, PubMed:18622031, PubMed:25917219).  May act through the wnt receptor cfz-2 to regulate QR neuroblast descendant migration, and to direct ALM migration (PubMed:16109397).  Also plays a role in axon growth and guidance in HSN and male CP neurons (PubMed:16109397).  In addition, together with wnt ligand cwn-1, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1 (PubMed:19561603).  Through the cam-1 receptor also probably regulates the outgrowth of neurites from RME GABAergic motor neurons (PubMed:20711352).  May act redundantly with other Wnt ligands such as cwn-1 and mom-2 to control seam cell polarity (PubMed:22022276).
What are the official names of this protein?
Protein Wnt-2.
What is the protein family that this protein belongs to?
Belongs to the Wnt family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: Y1612_STREM
Sequence: MFQKQQRIGLVIYLYYNRDARKVMKYGDLYYHSRRSRYLVIYINKEDMEEKLKDISRLTFVKEVKVSAFDDIDCDFVGNLHREPLEPQALPEQG
What are the official names of this protein?
UPF0298 protein Sez_1612.
What is the protein family that this protein belongs to?
Belongs to the UPF0298 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1261_YERPE
Sequence: MPQSSRYSDEHVEQLLSELVSVLEKHRTPTDLSLMVLGNMVTNLINTSIAPAQRKVLARSFAEALQASVREDKAH
What are the official names of this protein?
UPF0352 protein YPO1261/y2923/YP_0880.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: Y3443_DICDI
Sequence: MENNNNNNKNDNEINFKKIEINETLESGKFIESKIDMKLGELIIKVQSPMCFSFHKHLVNQFCFNCFSNSHEINNAKFNKFKVDINKNYIIRCNNCKLIYFCSDECFEKVMSIESFQDSTSTNIHTPLECLILSNYHDQTISPKINTLHDQTENRMIINYLSKIAYSTNNNNKFKLLLIEMNQLIGDFNNDNNNQTLSLNEIKNIKNKSFNLRKLFNNFFFNIDKVIIEELYAKSQRNSFGLWKNSDECFGLSMYGNQTIYNNNNDKDDNISISYFNHSCFPNCVRVQENQSISIYSLIPIKKGDELSISYIDIRMSKNDRLLHLKEIYYFECKCKRCTLPPLSNLSLEIEKTIENYTCKNQSIKCTGILYLPPFNKIQRICNFCHWKEPINN
What is the function of this protein?
Probable methyltransferase.
What are the official names of this protein?
SET domain-containing protein DDB_G0283443.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Protein: HWA_DANRE
Sequence: MSQLGSAVPSSNLPEGLPVSSLALLILVLIPCVLLLLLLNCLFVGYKLFRMTRRKRDRYGSEMSLMHSSYSTRQRITRFSDEPPVAPNRKTNYVSVSEPMLAPPITSSLTSSAERRATGQRAMFLRPDGATYAGSESLRVPHWRTSAPVLVQSSDSDMERVNTVPPNSPVLRVTPNGFSVPMTSLRRSSTMELESTSLDKIHVECESASIIPQENSCYVVSSSSSARGSGLDSDFGASAGVSLRILSMDSDGFPGSAWASALEWDYYDPSYVTQNHVPKHRPQAPPITTKQYWV
What is the function of this protein?
Key maternal determinant of the dorsal organizer and body axis formation in vertebrates that acts by promoting stabilization of beta-catenin (ctnnb1) (PubMed:30467143).  Localizes on the plasma membrane of the future dorsal blastomeres in early blastulas and binds to and promotes the tankyrase-mediated degradation of axin (axin1 and axin2) (PubMed:30467143).  Axin degradation results in stabilization and nuclear translocation of beta-catenin (ctnnb1) for activating organizer-specific target gene expression (PubMed:30467143).
What are the official names of this protein?
Protein huluwa.
What is the protein family that this protein belongs to?
Belongs to the huluwa family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein. Note=Enriched on the plasma membrane of blastomeres only in a small region in which the dorsal organizer will form.
Protein: GPSB_STRPG
Sequence: MTSIIYSPKDIFEQEFKTSMRGFDKKEVDEFLDNVIKDYENFNAQIEALKAENEALKKAKFQARNTVSATVQQPVPQPTRVAQSATNFDILKRISKLEKEVFGKQIIE
What is the function of this protein?
Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome.  Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression.  Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed.  Also contributes to the recruitment of PBP1 to the division complex.  Not essential for septum formation.
What are the official names of this protein?
Cell cycle protein GpsB, Guiding PBP1-shuttling protein.
What is the protein family that this protein belongs to?
Belongs to the GpsB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Shuttles between the lateral wall and the division site in a cell cycle-dependent manner.
Protein: THIE_THEVO
Sequence: MNEKKLRGLYLVTYDYYGAEFYEKIIDAIEGGVDILQYRDKTNAYSVKLQVARKLTSIAADYGIPFFVDDDPKLAKEAGADGVHIGRDDPPIEQVRDVFNGLIGVSTYGNLELATEAEKKGASYVAFGSFFHTDTKKDAGIYDIKILEKARHFVKIPIFVIGGINLETITKFCGYSIDGIAVVSAILAAENVKKAAKELKEKVEDIINGRC
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: VERL_CLORO
Sequence: MAVALFPILPIGCLLIYIIFKLWTRDERLKHLPPGPKGLPVIGNMLDMADTDKMMKKSKDWADEYGEIFYTKVGLYNFVWLSSPNAVRELMDKKGSIYSSRPPSPMINMVSNGERLNFLPYGHKWRTIRNILHSALNLETSSTYKPVQDFESKQALWEILHAKDDMEFNDINRRYSTSTIMTITYGLRVPTLQHPLYQDILTIVRHFSLATAPGEWVIDMVPMLADIVPQFLLQNWKNVARKWYKEDSEIYLALYNKLMDDIKRGTAPDCFLKDMAREKLKKNPIADTTAAFAAGALIEAGSDATTTALNNVVLACLLYPEIVKGAHEELDRVVGSDRMPEFSDEPNLPYIRGIAKETLRWRASTKVGPAHATTQDDWYNGYFIPKGTGVVLNWWAIHMNEKRWKDPERFDPTRYLEDTLTEAESMAQPNPELRDHFTFGAGRRNCPGVHIAHNSLFINIARIFWAFNKQKSKDADGKILEPSTAAQPGFLLTPVKFPCHFEARSDKHARIIEERWTEAQEKGIDGWKGKKESSSEENRGVSSR
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of 11'-deoxyverticillin A, one of the dimeric epipolythiodioxopiperazines (ETPs) from the verticillin family that act as mycotoxins (PubMed:28376389).  11'-deoxyverticillin A is required for normal conidiation (PubMed:28376389).  The nonribosomal peptide synthetase verP is speculated to be responsible for condensation of amino acids to form the carbon skeleton of verticillin, whereas the cluster-specific tailoring enzymes are involved in further modifications leading to the production of 11'-deoxyverticillin A (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase verL, Verticillin biosynthesis cluster protein L.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: AROC_RHILW
Sequence: MSHNTFGHLFRVTTWGESHGPALGCVVDGCPPGLRFKLEDLQVWLDKRKPGQSRFVTQRREDDLVKVLSGVMLDADGETMTTTGTPISMLIENTDQRSKDYGEIARQFRPGHADYTYDLKYGIRDYRGGGRSSARETAARVAAGGIARLVVPGVTVRGALVQIGKHKIDRRAWDWDQVGQNPFFSPDAAIVPVWEEYLDGIRKNGSSIGAVVEVIAEGVPAGLGAPIYSKLDQDIASLLMSINAVKGVEIGNGFAAAETSGEDNADEMRMGNDGVPIFLSNNAGGILGGISTGQPVVARFAVKPTSSILTERQSIDADGKNVDVRTKGRHDPCVGIRAVPIGEAMVACAIADHYLRDRGQTGRLK
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: QUEC_DESVH
Sequence: MPSCDGNALVIFSGGQDSTTCLGWALNRFRTVATIGFHYGQRHDVEMQCRQDVLAAIGDVRPGWKAHLGTDTVVEMGLFRELGETALTHDVAIEMGRNGLPSTFVPGRNLMFLTAAAACAYRQGIRHLVLGVCETDFSGYPDCRDDAMKAMQVALNLGMESRFVVHTPLMWLTKAQTWDMARDEGGQDFVELVLERSHTCYKGVRDVRHPWGYGCGTCPACELRRAGWDAYVAGHAVHGEGR
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.