PharMolix/UniProtQA huggingface dataset:
Protein: PTB_CLOAB
Sequence: MIKSFNEIIMKVKSKEMKKVAVAVAQDEPVLEAVRDAKKNGIADAILVGDHDEIVSIALKIGMDVNDFEIVNEPNVKKAALKAVELVSTGKADMVMKGLVNTATFLRSVLNKEVGLRTGKTMSHVAVFETEKFDRLLFLTDVAFNTYPELKEKIDIVNNSVKVAHAIGIENPKVAPICAVEVINPKMPSTLDAAMLSKMSDRGQIKGCVVDGPLALDIALSEEAAHHKGVTGEVAGKADIFLMPNIETGNVMYKTLTYTTDSKNGGILVGTSAPVVLTSRADSHETKMNSIALAALVAGNK
What is the function of this protein?
Catalyzes the conversion of butyryl-CoA through butyryl phosphate to butyrate.
What are the official names of this protein?
Phosphate butyryltransferase, Phosphotransbutyrylase.
What is the protein family that this protein belongs to?
Belongs to the phosphate acetyltransferase and butyryltransferase family.
Protein: CLPB_RICCN
Sequence: MNIDKFTAHAKSVIASSQLLAAKNDHQQILPLHLLSSLLSEETGIIQTLINNTGGNINLLKDQVQLELNKIPKVQVEGGGQVYSSAEALKVLEKASSIAKDNGDSFVTIERIFEALTYDNTIAGKILTNNGINNKKIATAILQFRKGKKADTESAENSYDALKKYGRDVTELAESGKLDPIIGRDEEIRRTVQVLSRRMKNNPVLIGEPGVGKTAIIEGLAQRIFSKDVPESLINCRIIELDMGALIAGAKYRGEFEERLKAVLSEIKESSGEIILFIDELHLLVGTGKTDGAMDASNLLKPMLARGELHCIGATTLDEYRKYIEKDAALARRFQPVYVSEPTVEDTISILRGIKEKYELHHAVRISDSAIVAAATLSNRYITDRYLPDKAIDLIDEACSRMKIELSSKPEELDELDRRIIQIKIELAALKKENDEHSKKKIEHLTTALEKLESQSYDMGAKWQAEKSKLQQTQKLKEELDRSRNELERAERDANLAKASELKYGIIPEIMKKLQEAESMDNKGLLKEIVSESDIASIISRITGIPIDTMLSSERERLLVMEQKLRESVIGQDKAIKGVSDAVRRSRAGIQDINRPLGSFLFLGPTGVGKTELTKALAGFLFDDRNAILRIDMSEYMEKHAISRLIGAPPGYIGYDQGGVLTEAVRRRPYQVILFDEVEKAHPDIFNIMLQILDEGRLTDSQGITVDFKNTIIVLTSNLGAEILVNQKEDEDTYKVKDEVMEYVKAVFKPEFLNRLDEIILFHRLNRNNIHDIVKIQLESLKKILLAQNIILEFDESALNYLAEKGYDPSFGARPLKRLIQREIQNNLAKMILAGEISSGKTVKINSKDKELKVTMS
What is the function of this protein?
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.  Acts before DnaK, in the processing of protein aggregates.  Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
What are the official names of this protein?
Chaperone protein ClpB.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBL_BROCO
Sequence: SVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAEVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYTKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIIMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIREASKWSPEFAAACEVWKE
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: LEPP_BACNA
Sequence: MTKEKVFKKKSSILEWGKAIVIAVILALLIRNFLFEPYVVEGKSMDPTLVDSERLFVNKTVKYTGNFKRGDIIILNGKEKSTHYVKRLIGLPGDTVEMKNDHLFINGNEVKEPYLSYNKENAKKVGINLTGDFGPIKVPKDKYFVMGDNRQESMDSRNGLGLFTKDDIQGTEEFVFFPFSNMRKAK
What are the official names of this protein?
Signal peptidase I P, SPase I, Leader peptidase I.
What is the protein family that this protein belongs to?
Belongs to the peptidase S26 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: Y510_ARCFU
Sequence: MNSKTHLLLALTMLIWAGSFIFIKIGLKELDPFNLAFYRFLLASPLLMAWVFWKRGLAKPSGSEWLHLSVLALSGVTLLYAFQFLALKYTTATNASILINTSAVFVALWGLVKGEANPRKLAGVFLSFAGVVLIVSKGTLEFFSSKTIFGDVLMIVDGFLWAVYTVLGSKMLLKYDHETLTAYAFALGTIFLIPFALMSGFANPVTFNPETVAALLYLSILCSVFAYVVWYYALTNADSTSVAVYVYLVPLFTAIFAFYALNEKPDFFTAIGGIITIAGVYLTTAKQHQ
What are the official names of this protein?
Uncharacterized transporter AF_0510.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TVP38_ASPTN
Sequence: MPADYTSTARALSLSTSPPLSSPTSEDGSYLPWRHLAPTGRRDSSSRSIRESNSLRHQVMNRINNASQRIIMTWRRMNFWQRIGAVLAAILANLLGIGFLVFTGKVFIWLKPVAEQWEHNPLVFFVLWLCVFFVSFPPLVGWSTFGTVAGYIFGVWKGWLLYASATVLGSTASFIVSRTILSKFVHRLMERDKRFAALALTLKYDGLKLLCMIRLCPLPYSVCNGAVSTFPTVHPLTYGLATAIITPKLLVPAFIGNRLRVLSEKGGEMSAGSKAVNICSIIITIAIGIFTGWYIYRRTLARAKELEAQEREGIRQSLEADHAAHRPHHAFFEDPEANIAATTLACDEEERIGFHDFDDDNVDLVLDDESGREISPKRTDGPYRDEFTDNDSDVFKDGDGTDGETYTLHTHVRQNPRS
What is the function of this protein?
Golgi membrane protein involved in vesicular trafficking and spindle migration.
What are the official names of this protein?
Golgi apparatus membrane protein tvp38.
What is the protein family that this protein belongs to?
Belongs to the TVP38/TMEM64 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein.
Protein: PUR7_CAMJD
Sequence: MTKKEMFYEGKGKKLFKTDDENLLISEFKDDLTAFNAEKRGNESGKGVLNCKISTEIFHLLEKNGIKTHLVETISDTEQVVKKCKIVPIEVIIRNVATGSLIKRLGIKDGTVLPFALVEFCLKDDALGDPFINDEHCLILNLVQNEAQISEIKNMARKINSILTPFFDNKNLRLIDFKIELGLTKDNDLVLADEISPDSCRFWDKFSNEKLDKDRFRQDLGNVKMAYEEVLKRILN
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ALBU_NEOFS
Sequence: DAEHKSNICKHFQVVGEEKFKNIILVTQDGHGPFIQVSKEEQCKHYAENRVPYMGNFIYTAAKRHPDLPATEVLIYAFXYESGAVLVSYPEMVGCCPPDVL
What is the function of this protein?
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs.  Its main function is the regulation of the colloidal osmotic pressure of blood.
What are the official names of this protein?
Albumin.
What is the protein family that this protein belongs to?
Belongs to the ALB/AFP/VDB family.
What are the subcellular locations of this protein?
Secreted.
Protein: TAY1_YARLI
Sequence: MSHFGDHVGIDPAIMKQYSEHHNGSHDNDDKDKEDKEKQNTEAVAAAAVQLDASLLASGILDDFEKAKKEEEEANGNNNASNDQQNASDRHVGDMLEQHSQQHQQSQEHDTSYINTYIEDKVPLTSVLIPGDRRVSDREASDRIAATTRRVRLRWTQEETADLMEGCKVHGVGNWKKILTDPRFRFNNRTAVDLKDRFRTCFPEDYRRLYPNARSRKFGKKTNVMAVNDDLVKVNRKERRVFTPEEDERLLNGFMKHGPSWSNIQRDNELGLFERRSTDLRDRFRNAFPLEYAAAGFKARGPKRRPVVEATHGNTLQTIFSASDGSEMSPRKYHRVQEQMDRQPVMRVHPQAPMDQGVDRDHMTQQFTQELQPQAHSRKQQGGDGLKEEVFAAAQNQSYNNYYYQK
What is the function of this protein?
Telomere-binding protein that mediates telomere clustering by promoting formation of head-to-head dimers of DNA molecules through the telomeric tracts.  Binds specifically 5'-TTAGTCAGGG-3' repeats in subtelomeric regions.
What are the official names of this protein?
telomere-associated protein 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome, telomere.
Protein: FGFR3_MOUSE
Sequence: MVVPACVLVFCVAVVAGATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVELSCHPPGGAPTGPTVWAKDGTGLVASHRILVGPQRLQVLNASHEDAGVYSCQHRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTPGGPSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPPSNGGPRT
What is the function of this protein?
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis.  Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development.  Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.  Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation.  Required for normal development of the inner ear.  Phosphorylates PLCG1, CBL and FRS2.  Ligand binding leads to the activation of several signaling cascades.  Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.  Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway.  Plays a role in the regulation of vitamin D metabolism.  Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling.  Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, STAT5A and STAT5B.  Plays a role in postnatal lung development.
What are the official names of this protein?
Fibroblast growth factor receptor 3, FGFR-3, Heparin-binding growth factor receptor.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor (By similarity).
Protein: CAPSD_HVAVE
Sequence: MTSNPETPVVSNVTLSELRSDVNKRGTIDSYIYGPDEQVTTYFVREIRPCAAFSKMPVLLNTGNGSNKFGGTFTMPINASGDYLLALTAYISISAGKLRSYAAGTESSYFPKLAHKLIKSVRLKVDAKPLVELSSNFMDTWSEFMIDGGNYEAYTNMVGGDFQYSRSVDIGAKTLVLPIPLYFSRDSGVALPIGMMVNNRVTVEFVFRKLSDLLIKENVPDTGAGTGFMNMLTDGDFATPPEITKFEVVADFAVVTDFEIDRTSCSPHYILMEKPTDIAATEILKPTEAGSTLSYDIEHSSGILKALFFGVRNITHSEYLDYYEVGLPKSNNGVRSIGVSALSKIGIKCGDRYRVPMLPAEHFVFTEPYRAACRVPTRNRGQYMYSFALDLKTVDPKGSINPSNFNSSISVVIEPSEALRNSAETFEFTAIALTSYILYIDNGSLKKIDNGGDFN
What is the function of this protein?
Major protein of the capsid.
What are the official names of this protein?
Major capsid protein.
What is the protein family that this protein belongs to?
Belongs to the ascoviridae capsid protein family.
What are the subcellular locations of this protein?
Virion.
Protein: RL20_YERPE
Sequence: MARVKRGVIARARHKKILKQAKGYYGARSRVYRVAFQAVIKAGQYAYRDRRQRKRQFRQLWIARINAAARQNGLSYSRFINGLKKASVEIDRKILADIAVFDKVAFSALVEKAKAALA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PSBL_SPIOL
Sequence: MTQSNPNEQNVELNRTSLYWGLLLIFVLAVLFSNYFFN
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization (By similarity).  Probably involved in PSII assembly (PubMed:7957890).  May be involved in PSII dimerization (PubMed:9632665).
What are the official names of this protein?
Photosystem II reaction center protein L, PSII-L.
What is the protein family that this protein belongs to?
Belongs to the PsbL family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single- pass membrane protein.
Protein: MINE_BURCH
Sequence: MSILSFLLGEKKKSASVAKERLQLIIAHERVGGRPPADYLPALQKELVAVISKYVHISDDDIRVSLERQDDLEVLEVKIEIPQA
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: TRMD_PHOLL
Sequence: MWIGVISLFPEMFRAITDYGVTGRAVKNGLLSIECWNPRDFTYDRHRTVDDRPYGGGPGMLMMVQPLREAIHAAKTAAGEGAKVIYLSPQGRKLNQQGVCELATNEKLILICGRYEGIDERVIQTEIDEEWSIGDYVLSGGEIPAMTMIDSVSRFIPGVLGHQASAEEDSFADGLLDCPHYTRPEVLDGMEVPPVLLSGNHAEINRWRMKQSLGRTWLRRPELLENLALTDEQRILLTEFQREHLTEATN
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOB_GOSBA
Sequence: MLGDENGEMSTIPGLNQIQFEGFCGFMDRGLTEELYKFPKIEDTEQEIEFQLFVETYQLVEPLIKERDAVYESLTYSSELYVSAGLIWKTSKDMQEQTIFIGNIPLMNSLGTSIVNGIYRIVINQILQSPGIYYRSELDHNGISVYTGTIISDWGGRLELEIDRKARIWARVSRKQKISILVLSSAMGSNLREILENVCYPEIFLSFLTDKEKKKIGSKENAILEFYQQFSCVGGDPVFSESLCKELQKKFFQQRCELGRIGRRNMNQRLNLNIPQNNTFLLPRDILAAADRLIGMKFGMGPLDDMNHLKNKRIRSVADLLQDQFGLALVRLENVVRGTICGAIRHKLIPTPQNLVTSTPLTTTYESFFGLHPLSQVLDRTNPLTQIVHGRKLSYLGPGGLTGRTANFRIRDIHPSHYGRICPIDTSEGINVGLIGSLAIHARIGHWGSLESPFYKIFERSKKAQMLYLSPSRDEYYMVAAGNSLALNQGIQEEQVVPARYRQEFLTIAWEQVHLRSIFPFQYFSIGASLIPFIEHNDANRALMSSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVPAIADHEGKIISTDTDKIILSGNGDALGIPLVMYQRSNKNTCMHQTARVRRGKCIKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITNEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQVAKESSYAPEDRLLRAILGIQVSTSKETCLKLPIGGRGRVIDVRWVQKKGGSSYNPETIRVYISQKREIKVGDKVAGRHGNKGIISKILPRQDMPYLQDGRPVDMVFNPLGVPSRMNVGQLFECSLGLAGSLLDRHHRIAPFDERYEQEASRKLVFSELYQASKQTANPWVFEPEYPGKSRIFDGRTGGPFEQPVIIGKPYILKLIHQVDDKIHGRSSGYYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAHILQEMLTYKSDHIRARQEVLGTTIIGGTIPKPEDAPESFRLLVRELRSLALELNHFLVSEKNFQINRKEA
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, PEP, Plastid-encoded RNA polymerase subunit beta, RNA polymerase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CBP1_PYRFU
Sequence: MEEVFQNETIKQILAKYRRIWAIGHAQSVLGWDLEVNMPKEGILERSVAQGELSVLSHELLLHPEFVNLVEKAKGLENLNEYERGIVRVLDRSIRIARAFPPEFIREVSETTSLATKAWEEAKAKDDFSKFEPWLDKIISLAKRAAEYLGYEEEPYDALLDLYEEGLRTRDVEKMFEVLEKKLKPLLDKILEEGKVPREHPLEKEKYEREWMERVNLWILQKFGFPLGTRARLDVSAHPFTTEFGIRDVRITTRYEGYDFRRTILSTVHEFGHALYELQQDERFMFTPIAGGVSLGIHESQSRFWENIIGRSKEFVELIYPVLKENLPFMSNYTPEDVYLYFNIVRPDFIRTEADVVTYNFHILLRFKLERLMVSEEIKAKDLPEMWNDEMERLLGIRPRKYSEGILQDIHWAHGSIGYFPTYTIGTLLSAQLYYHIKKDIPDFEEKVAKAEFDPIKAWLREKIHRWGSIYPPKELLKKAIGEDMDAEYFVRWVKEKYL
What is the function of this protein?
Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues, but not Pro, Gly, Asp and Glu.
What are the official names of this protein?
Thermostable carboxypeptidase 1, Carboxypeptidase Pfu, PfuCP.
What is the protein family that this protein belongs to?
Belongs to the peptidase M32 family.
Protein: RL18_CAMFF
Sequence: MVANVLKRKISLRIKRKRRIRAKISGTPSCPRISIFKSNRTIYVQAIEDINATTLCASDGRKLGIKANKSGAAVLAKDIAGKLSAKGINEAVFDRNGYLYHGVVAAFAEALRENGIKL
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: CD3G_PIG
Sequence: MEQGKHLAGLILAITLLQGTMAQLKEGKHSVLLDDNREDGSVLLTCGLPDQNIRWFKDGKEICSLNNSRSTCNLGSSSKDPRGIYWCEGSKENSKRLQVYYRMCQNCIELNSATVSGFIFTEIISLFFLAVGVYFIAGQDGVRQSRASDKQTLLSNDQLYQPLKDREDDQYSHLQGNNSRKN
What is the function of this protein?
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.  When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z.  All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.  Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways.  In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface.  Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
What are the official names of this protein?
T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: HHAT_MOUSE
Sequence: MLPGWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEMDTLFGGLKKDPTDFEWNFWMEWGKRRLVWLFIGHMAVSQLATLLTKKHRPWIVMVYGMWACWCVLGAPGVVMVLLHSTIAFCVAQFRSVLLSWLCSLLLLSTLRLQSVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQPTPSAQGASHSYPWLLTYVFYYPVFHNGPILNFPEFFRQMQQPELNSLQHSLCIVAKGLGRLLCWWWLAELMVHLMYMHALYSSAPLLESVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTATTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLETPCVRETLARHLSPQAHHRLHALLAACSTSMLILFNLVFLGGIQVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVDIAWAQTYTVL
What is the function of this protein?
Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling during limb development (PubMed:15075292).  It also catalyzes N-terminal palmitoylation of DHH (By similarity).  Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs (By similarity).  Plays a role in proper testis cord formation and the differentiation of Leydig cells (PubMed:24784881).
What are the official names of this protein?
Protein-cysteine N-palmitoyltransferase HHAT, Hedgehog acyltransferase, Skinny hedgehog protein.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family. HHAT subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Co-localizes with SHH in the ER and Golgi membrane.
Protein: LDB16_YEAST
Sequence: MFVVDWSVQLCMGVISPLFRALVQLPLSIFVWNGFQLVALPINIPLRLFLGTSLSRLVAQTSTLDFYVVLTLFQYFAVLCAFGSIIGLIFGFILGVFHSICGVPSVYISLEWKRWFAPIRTVLERASTSIVNIMRGQTIAPIPMPKPNPTHISKPNMKKFHDEPGADDMTITHDVNCYITPCQTPTNEKIQHYNNDSFNTTTTDDEPTDIWDRSDTYQNSFVTNETLMSLSNRAKLRRNASDADIVNIKILRRNSR
What is the function of this protein?
May be involved in protein-linked oligosaccharide phosphorylation since the deletion reduces the negative charge of the cell surface.
What are the official names of this protein?
Protein LDB16, Low dye-binding protein 16.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Lipid droplet.
Protein: SPT48_MOUSE
Sequence: MDMEVKTMPGKISIPRRFIFSEGKAIEHPDYPHYSNLLQKMNMPSVKGLEDRHNCVRFEKKCNPTFLKFHPYPPSVLPDYHLHYPYPPPYGRAYPLAPLRDDVPLGDPCSGFMSPGGDANLKPNIGRAIPNLVSFHDVKPQNRVPRPDKGFQTTIKRQTILAEELKQDRRWNSRKVPDISIKAKLGGWTSPMKVVPVPVHEHEVGTLSRIYTFDEEAISTDDSEPLVQLDKKYNIKDSFYKSSTQKAYEDVPWDKMLPPKLDPEETTVEKAADHISQCFSLKRYERLPAITQMVGGLWDRFQTRLFSAPAKPINFVSPSTRSKYIPLYTGHVQSTDADNVDNPYGDIKSVASPRHSKLQYTNSSRSANIPGYTGKVHFTATHPTNSNIPSREPSADSEMNRLLLQEMRVDRFRHQGPMSQMVTTVKPYNPFNKKEKETLEY
What is the function of this protein?
Essential for normal spermatogenesis.
What are the official names of this protein?
Spermatogenesis-associated protein 48, Post-meiotic spermatogenesis protein 1.
Protein: PEBA_PROM0
Sequence: MFDSLVDFLKTNIDELNGHEVQISGEFKEHHNEDSKYIIKNWLFSSSEYRKWRITRLDGGKKLQVFNTVAYPNFNSEMPILGADILWFGNSQKLLAILDYQPLIQENKYLEKYCSSLGSIKKKYSAFDNNKMKNIYDSKKYFSPWVIICRGNKLNLDRDLNNIFHSFVKNYLNINKSNPVNQFLNAEEIKINQIKYDKYSFEKDPADKLFKSFFGEKWTKKFINKFLFTLNNEIIH
What is the function of this protein?
Catalyzes the two-electron reduction of biliverdin IX-alpha at the C15 methine bridge.
What are the official names of this protein?
15,16-dihydrobiliverdin:ferredoxin oxidoreductase.
What is the protein family that this protein belongs to?
Belongs to the HY2 family.
Protein: SYGB_ECOL6
Sequence: MSEKTFLVEIGTEELPPKALRSLAESFAANFTAELDNAGLAHGTVQWFAAPRRLALKVANLAEAQPDREIEKRGPAIAQAFDAEGKPSKAAEGWARGCGITVDQAERLTTDKGEWLLYRAHVKGESTEALLPNMVATSLAKLPIPKLMRWGASDVHFVRPVHTVTLLLGDKVIPATILGIQSDRVIRGHRFMGEPEFTIDNADQYPEILRERGKVIADYEERKAKIKADAEEAARKIGGNADLSESLLEEVASLVEWPVVLTAKFEEKFLAVPSEALVYTMKGDQKYFPVYANDGKLLPNFIFVANIESKDPQQIISGNEKVVRPRLADAEFFFNTDRKKRLEDNLPRLQTVLFQQQLGTLRDKTDRIQALAGWIAEQIGADVNHATRAGLLSKCDLMTNMVFEFTDTQGVMGMHYARHDGEAEDVAVALNEQYQPRFAGDDLPSNPVACALAIADKMDTLAGIFGIGQHPKGDKDPFALRRAALGVLRIIVEKNLNLDLQTLTEEAVRLYGDKLTNANVVDDVIDFMLGRFRAWYQDEGYTVDTIQAVLARRPTRPADFDARMKAVSHFRTLEAAAALAAANKRVSNILAKSDEVLSDRVNASTLKEPEEIKLAMQVVVLRDKLEPYFAEGRYQDALVELAELREPVDAFFDKVMVMVDDKELRINRLTMLEKLRELFLRVADISLLQ
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUAA_MOUSE
Sequence: MALRLLRLVPASAPARGLAAGAQRVGRIHTSVHCKLRYGLLAAILGDKTTKKLHEYSRVITVDGNICSGKNKLAKEIAQQLGMKHYPEAGIQYSSTTTGDGRPLDIEFSGSCSLEKFYDDPKSNDGNSYRLQSWLYASRLLQYADALEHLLSTGQGVVLERSIYSDFVFLEAMYNQGYIRKQCVDHYNEIKRLTLPEYLPPHAVIYIDVPVPEVQSRIQKKGDPHEMKVTSAYLQDIENAYKKTFLPKMSEMCEVLVYDSWEAEDPTKVVEDIEYLKYNKGPWLKQDDWTFHYLRMLVQDKTEVLNYTTIPVYLPEITIGAHQGSRIYNSFRELPGRKYAPGYNAEVGDKWIWLK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial, Complex I-42kD, CI-42kD, NADH-ubiquinone oxidoreductase 42 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFA10 subunit family.
What are the subcellular locations of this protein?
Mitochondrion matrix.