PharMolix/UniProtQA huggingface dataset:
Protein: PB1F2_I59A0
Sequence: MEQEQDTPWTQSTEHINIQKKGNGQQTQKLGRPNLTQLMDHYLRTTNQVDMHKQTASWKQWLSLKNPIQESLKTRALKRWKSFSKQGLTN
What is the function of this protein?
Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection.  Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death.  Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS.  Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins.  Monocytic cells are more affected than epithelial cells.  Seems to disable virus-infected monocytes or other host innate immune cells.  During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1.  These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
What are the official names of this protein?
Protein PB1-F2.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB1-F2 family.
What are the subcellular locations of this protein?
Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol.
Protein: RL5_BACCE
Sequence: MNRLKEIFQKEITPALVSKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the two subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs (By similarity).
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: SNX41_CRYNB
Sequence: MDSDTSPNPFASSPPSSPSPRPSLPPPVPRKPSSLVSAASGSPPPTHRASFPDPARHPKMGATVPGPKPKTGYCCSIDKDISAGEQVHIVDALKTTEGGTASYITYVIRLGTHTVRRRYSAFLSLHQSLTGLYPVLIIPPIPSKQSLTDYAVKGQSKAREDATIIARRKRLLEDFLQRLIRHPILGGEHVLHRFLEEDVSWSEVLHSPPISLLSKNPLHAPSHNPTFQPTTPTSPSEAPATTSYIAHHLLPTPSPSHPLRQPDQRFMDSEAFTEKFQSHFSGTMEKVNRRVTKRWGERAHDMSELGGIWNGFSLVEQGKLGDAIEKVGRAVDAEYLATAALLQSWEKTTTEPLHIYSQFATLIRARLSFRHQKHVQYELVQEALETQRDKLEILENAEREARRLEEALERGGSVLASPQLEPEAARDERERAQRRARASQGFGLLSAVKHSLSGMIDMDPEATRRANIAKTRDNISQLEDSYQAAAQDLKYASMTLQADLDRFQRQKVADLREMAINLSQVHRDWCKQNLEAWKAAQAAVREIDPHPNRPAQTQTQVQSQQSHAGPSTLHAQTEDDVSKLGVDAMKNEIERVEIEIADKPLPKPSLAETGGDGVVPSPQPRQENDTEEREGHGPLGPL
What is the function of this protein?
May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
What are the official names of this protein?
Sorting nexin-41.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Endosome membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Note=Endosome and other perivacuolar punctate structures.
Protein: BIK1_ARATH
Sequence: MGSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHLV
What is the function of this protein?
(Microbial infection) Xanthomonas campestris effector AvrAC/XopAC-mediated uridylylation prevents activation by phosphorylation at the same residues, thus affecting immune responses and reducing defense responses toward X. campestris, mediating avrAC/XopAC virulence functions.
What are the official names of this protein?
Serine/threonine-protein kinase BIK1, Protein BOTRYTIS-INDUCED KINASE 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: HOMEZ_RAT
Sequence: MSPNKDSSSLNSSGAGLVCLPPVSEELQLVWTQAVQTSELDGNEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYHRDQLLFKSLLSFTHHAVRPPQEMPPVTPPEQVALGLRPLALSEPTQMKGLKVEPEEPFQVSQLPLNHQKVKEPLMMGSRTLNHQSDCQDLQISGLSKEQAGGGPDQSCGGGTASWNHSIAVHQPDKSPLISLLDNSCKEESEPSGTPPSSSASSPFQVLANGTTATPKPLQPLGYIPQSFSPSEQALSPQVEPLWSQRLRNNSVPSRVGPTEYLSPDMQHQRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVLGTPSFQDPAISTSSTRSLKEWAKTPPLPAPPPPPDIRPLERYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEVVVCLDEEEEEEDEELPEDGEEEEEEEEEEDDDVIIRD
What is the function of this protein?
May function as a transcriptional regulator.
What are the official names of this protein?
Homeobox and leucine zipper protein Homez, Homeodomain leucine zipper-containing factor.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1732_PSEA6
Sequence: MLRWAVIFLVIALVAAVLGFGGIAGSAAGIAKIIFFVFLVLLVISVVMGRRKV
What are the official names of this protein?
UPF0391 membrane protein Patl_1732.
What is the protein family that this protein belongs to?
Belongs to the UPF0391 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: EFG_STRP8
Sequence: MAREFSLAKTRNIGIMAHVDAGKTTTTERILYYTGKIHKIGETHEGASQMDWMEQEQERGITITSAATTAQWDGHRVNIIDTPGHVDFTIEVQRSLRVLDGAVTVLDSQSGVEPQTETVWRQATEYGVPRIVFANKMDKIGADFLYSVQTLHDRLQANAHPIQLPIGAEDDFRGIIDLIKMKAEIYTNDLGTDILEEDIPEEYLEQAQEYREKLIEAVAETDEDLMMKYLEGEEITNDELIAGIRKATINVEFFPVLCGSAFKNKGVQLMLDAVIAYLPSPLDIPAIKGVNPDTDAEEERPASDEEPFAALAFKIMTDPFVGRLTFFRVYSGVLNSGSYVMNTSKGKRERIGRILQMHANSRQEIETVYAGDIAAAVGLKDTTTGDSLTDEKAKVILESIEVPEPVIQLMVEPKSKADQDKMGVALQKLAEEDPTFRVETNVETGETVIAGMGELHLDVLVDRMKREFKVEANVGAPQVSYRETFRASTQARGFFKRQSGGKGQFGDVWIEFTPNEEGKGFEFENAIVGGVVPREFIPAVEKGLIESMANGVLAGYPMVDVKAKLYDGSYHDVDSSETAFKIAASLALKEAAKSAQPAILEPMMLVTITAPEDNLGDVMGHVTARRGRVDGMEAHGNSQIVRAYVPLAEMFGYATVLRSATQGRGTFMMVFDHYEDVPKSVQEEIIKKNKGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTS_ROSCS
Sequence: MTPAERRAFERQLQQEFPGLELHAWYRQYRSLKAAHPDAILLYRLGDFYETFDDDAKLVADLLEVTLTYKEFASQKGRDQKQRCPMAGIPYHAVEGYVARLVGAGYRVAIAEQMTETPSSRTDTRPRSIFAAGIEQTALIGGHKMVERKVVRIITPGTIIESGMLPAERNNYLAALIADHGRIGLAYADLSTGEFAAIEFSGERAAQQAQGELARLNPAEILVPDRADLRLPGLEPSSARLEQDLEFLTREERERVLPGERIARRVERENHARWAHGHVTAWSEQRWDLRNARDTLLHQFGVHSLAGFGLADRPLAIRAAGAIVQYARETQQGTVANLRAIRVYTPGDAMVLDPQTQRNLELLEGNSGTTRGSLIGVLDQTRTPMGARLLRRWISQPLCDLARLRARHDAVDHFVNDAILRASVRETLRRVGDMERVVNRIIQGSGVATPRDMARLRDALRALPDLVAALEDWTPPQEDVDLSGMSALQESAALAAAPLDGITPPDDDHTEQEPTTISLRAQREARRRVSARLTGDDLFDEEEEQENAGQPAPLPTTETVRASGESARPSFEMPSLHGHGESPTLDACADILAFLETAIDDDPPALLGASNYLRAGDNGELPRRVIRPGFEPEIDRVVAASRDAQRWISELEPKERERTGIKSLRVDYNRVFGYYIEVPKTYADQVPKHYIRKQTLTTGERYFTDELKRYEEIVEQAQQRLIDLERRAFARICETLAGAGVRLLRTARTIATIDVFAALAEAAVRGRYVRPELYDDTRLRIIGGRHPVVEQTLDETFIPNDIEMDTETRQICLITGPNMSGKSTVLRQVALIALMAQIGSFVPADAAEIGVVDRIFTRIGAQDDIATGRSTFMVEMTETAALLAQSTHRSLIILDEVGRGTSTYDGMAIAQAVIEYIHNEPRLGCRTLFATHYHELTDLERTLPRLKNYHMAATEQDGRVVFLHELRPGGADRSYGIHVAELAGIPQPVIRRATELLAELERRAPRSTPQPAPERTEERPAAGRPTARSHSAARGDPPRAPDGQLSLFDLTPGPVIEMLRRLDINQLTPLEALNKLYELQKLARIGGG
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity.
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: LPTE_ECO8A
Sequence: MRYLATLLLSLAVLITAGCGWHLRDTTQVPSTMKVMILDSGDPNGPLSRAVRNQLRLNGVELLDKETTRKDVPSLRLGKVSIAKDTASVFRNGQTAEYQMIMTVNATVLIPGRDIYPISAKVFRSFFDNPQMALAKDNEQDMIVKEMYDRAAEQLIRKLPSIRAADIRSDEEQTSTTTDTPATPARVSTTLGN
What is the function of this protein?
Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.  Required for the proper assembly of LptD.  Binds LPS and may serve as the LPS recognition site at the outer membrane.
What are the official names of this protein?
LPS-assembly lipoprotein LptE.
What is the protein family that this protein belongs to?
Belongs to the LptE lipoprotein family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: NADD_ACET2
Sequence: MEVNVKRIGILGGTFDPIHNGHLIMAEIIRGAFELDRVLFIPSGNPPHKKNQTVTDAEHRYNMVCEALKGNPYFEKSRIEVDREGYTYTIDTLGILNEQYRGIADLYYIIGADVLYDLLTWKDYEKVFGICKFIAALRPGTGKEGFRERIKYLEDRFSASILEAEIPLIEISSTMIRNRVKEGKSIKYLVPETVENYIKKEGLYLK
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: GB_ILTV6
Sequence: MASLKMLICVCVAILIPSTLSQDSHGIAGIIDPRDTASMDVGKISFSEAIGSGAPKEPQIRNRIFACSSPTGASVARLAQPRHCHRHADSTNMTEGIAVVFKQNIAPYVFNVTLYYKHITTVTTWALFSRPQITNEYVTRVPIDYHEIVRIDRSGECSSKATYHKNFMFFEAYDNDEAEKKLPLVPSLLRSTVSKAFHTTNFTKRHQTLGYRTSTSVDCVVEYLQARSVYPYDYFGMATGDTVEISPFYTKNTTGPRRHSVYRDYRFLEIANYQVRDLETGQIRPPKKRNFLTDEQFTIGWDAMEEKESVCTLSKWIEVPEAVRVSYKNSYHFSLKDMTMTFSSGKQPFNISRLHLAECVPTIATEAIDGIFARKYSSTHVRSGDIEYYLGSGGFLIAFQKLMSHGLAEMYLEEAQRQNHLPRGRERRQAAGRRTASLQSGPQGDRITTHSSATFAMLQFAYDKIQAHVNELIGNLLEAWCELQNRQLIVWHEMKKLNPNSLMTSLFGQPVSARLLGDIVAVSKCIEIPIENIRMQDSMRMPGDPTMCYTRPVLIFRYSSSPESQFSANSTENHNLDILGQLGEHNEILQGRNLIEPCMINHRRYFLLGENYLLYEDYTFVRQVNASEIEEVSIFINLNATILEDLDFVPVEVYTREELRDTGTLNYDDVVRYQNIYNKRFRDIDTVIRGDRGDAIFRAIADFFGNTLGEVGKALGTVVMTAAAAVISTVSGIASFLSNPFAALGIGIAVVVSIILGLLAFKYVMNLKSNPVQVLFPGAVPPAGTPPRPSRRYYKDEEEVEEDSDEDDRILATRVLKGLELLHKDEQKARRQKARFSAFAKNMRNLFRRKPRTKEDDYPLLEYPSWAEESEDE
What is the function of this protein?
Envelope glycoprotein that forms spikes at the surface of virion envelope.  Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans.  Involved in fusion of viral and cellular membranes leading to virus entry into the host cell.  Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.  May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.
What are the official names of this protein?
Envelope glycoprotein B, gB.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein B family.
What are the subcellular locations of this protein?
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Host Golgi apparatus membrane; Single-pass type I membrane protein. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).
Protein: TIG_BACCR
Sequence: MSTKWEKLEGNVGVLTIEVDAKEVNNSIDAAFKKVVKTINVPGFRKGKMPRPLFEQRFGIESLYQDALDIILPKAYGEAIEEAGIFPVDHPEIDIEKFEKNANLIFTAKVTVKPEVKLGEYKGLAVEKVETTVTDEDVENELKSLQERQAELVVKEEGTVENGDTAVIDFEGFVDGEAFEGGKGENYSLAIGSGTFIPGFEEQVIGLKSGESKDVEVSFPEEYHAAELAGKPATFKVTIHEIKTKELPELNDEFAKEADEAVATLDELKAKLRTNLEEGKKHEAEHKVRDEVVELAAANAEIEIPEAMINTELDRMVREFEQRLSQQGMNLELYYQFTGTDADKLKEQMKEDAQKRVRINLVLEAIIEAENIEVTEEEVTAEVEKMAEMYGMPVDAIKQALGSVDALAEDLKVRKAVDFLVENAA
What is the function of this protein?
Involved in protein export.  Acts as a chaperone by maintaining the newly synthesized protein in an open conformation.  Functions as a peptidyl-prolyl cis-trans isomerase.
What are the official names of this protein?
Trigger factor, TF, PPIase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. Tig subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.
Protein: TYPH_PHOPR
Sequence: MYLPQEIIRKKRDNVELTADEINFFIQGIAKETMSEGQIAAFAMAIYFNDMTMDERVALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGFVPMISGRGLGHTGGTLDKLESIPGYNITPTNDVFGQVTKDAGVAIIGQTGDLAPADKRVYATRDVTATVDNISLITASILSKKLAAGLGSLVMDVKVGSGAFMPTYEASEDLAKSIVAVANGAGTKTTALLTDMNQVLASTAGNALEVREAVQFLTGEYRNPRLFEVTMALCAEMLVNSGLASDIEQAREQLQAVLDNGKAATCFGKMVAGLGGPVDFMENYDNYLEKAEIAKPVFAETTGYAYAMDTRGLGMAVVGMGGGRRVASDSIDYAVGLSDMIRLGDEVNTDTALCVIHARSEAQWQEAANAVRANITIADEKPAPTPDVYRRIRAEDI
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: MARA_SALTI
Sequence: MSRRNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQTLTRTFKNYFDVPPHKYRITNMHGESRYMLPLNHGNY
What is the function of this protein?
May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype.  It can also activate genes such as sodA, zwf and micF (By similarity).
What are the official names of this protein?
Multiple antibiotic resistance protein MarA.
Protein: HLGB_STAA8
Sequence: MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
What is the function of this protein?
Toxin that seems to act by forming pores in the membrane of the cell.  Has a hemolytic and a leucotoxic activity.  Promotes host AMFR-mediated inflammation by mediating 'Lys-27'-linked ubiquitination of TAB3, TAK1-TAB3 complex formation and phosphorylation of TAK1/MAP3K7 (PubMed:36593296).  In turn, activates host NF-kappa-B signaling pathway.
What are the official names of this protein?
Gamma-hemolysin component B, H-gamma-1, H-gamma-I, Leukocidin f subunit.
What is the protein family that this protein belongs to?
Belongs to the aerolysin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LCE1B_HUMAN
Sequence: MSCQQNQQQCQPPPKCIPKCPPKCLTPRCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGCC
What is the function of this protein?
Precursors of the cornified envelope of the stratum corneum.
What are the official names of this protein?
Late cornified envelope protein 1B, Late envelope protein 2, Small proline-rich-like epidermal differentiation complex protein 2A.
What is the protein family that this protein belongs to?
Belongs to the LCE family.
Protein: THIM2_STRZJ
Sequence: MQEFTNPFPIGSSSLIHCMTNEISCEMLANGILALGCKPVMADDPREVLDFTKQSQALFINLGHLSAEKEKAIRIAASYAAQVCLPMVVDAVGVTASSIRKSLVRDLLDYRPTVLKGNMSEIRSLVGLKHHGVGVDASAKDQETEDLLQVLKDWCQTYHGMSFLVTGPKDLVVSKNQVAVLGNGCAELDWITGTGDLVGALTAVFLSQGKTGFEASCLAVSYLNIAAEKIVVQGMGLEEFRYQVLNQLSLLRRDENWLDTIKGEVYE
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 2, 4-methyl-5-beta-hydroxyethylthiazole kinase 2, TH kinase 2, Thz kinase 2.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: DAPH_STRMU
Sequence: MTAQKMSAQEIIAFIGNAEKKTNVKVTFEGALAAALPENVVKLGNVLFGDWKDIEPLLANLTENKDYVVEQDGRNSAVPLLDKRNINARIEPGAIIRDQVTIEDNAVVMMGAIINIGAEIGEGTMIDMGAILGGRATVGKNSHIGAGAVLAGVIEPASADPVRIGDNVLVGANAVIIEGVQVGSGSVVAAGAIVTQDVPDNVVVAGVPARVIKEIDEKTQQKTALEDALRNL
What is the function of this protein?
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, Tetrahydrodipicolinate N-acetyltransferase, THP acetyltransferase, Tetrahydropicolinate acetylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. DapH subfamily.
Protein: RNY_SULDN
Sequence: MLNEILSGSSAAVISGLVGFYISKKITNANFDIYVEKAKAQAGAIENEAQLLLYKANIKSQEIEQEATKLYENAKDRAKADLSLREEDVNRKEQTFKRYKQNEERRLQDEVSTLKARQVDLKRNEKSLSSLKKRYEDKIDEALNAIEHCAGMTKEEATRVLLEKVEEKSRSEIAHVVRRYENEAKVEAKKRANYILAQATSRFAGEFAAERLTNLVHLNDDELKGRIIGKEGRNIKTLETLLGVDIIIDDTPNAILVSSFNLYRRAIATKTLELLIQDGRIQPARIEEIYNKVCEDFEADTLSEGEEIVIDLDIGVMHPELVKLIGKLRYRASYGQNALSHTLEVAHLAGIMASEMGGDARLAKRAGLLHDIGKALTHEHEGSHVDLGVQVCNRYNEHSVVINAIYAHHGHEEINSIECGAVCAADALSAARPGARREVLESFLKRVTAIEEIASQHSGVKQAYAINAGREVRVIVNASLINDDESILLAKEIASEIEHGVQYPGEIKVNVIRESRAVEFAK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: MNME_LACLM
Sequence: MTLTQEFDTIAAISTPLGEGAIAIVRLSGTDALKIAQSVYKGKNLAQVASHTINYGHIFEEERLVDEVMVSVMRAPKTFTREDIVEINTHGGIAVTQEILQLLLRNGARLAEPGEFTKRAFLNGRIDLAQAESVMDLIRAKTDKAANIAVKQLDGSLSKMINNIRQEILESLAQVEVNIDYPEYDDVETMTSQMLLEKTAHFEQLLENLLSTAKRGKILREGLKTAIIGRPNVGKSSLLNQLLREEKAIVTDIAGTTRDVITEFANIGGVPLELVDTAGIRETDDLVEAIGIERSKKALAEADLVLLVLDASLELTDKDLELLELSKNANRIVLLNKTDLPEKLDINQISGDFIRISALKNENLSAVEEKINQIFFAGEIEAKDATVLSNARHISLVEEALKALKEANNGLALGLPVDLIQVDVTRCWQLLGEITGEAAPDELITQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KVD21_HUMAN
Sequence: MSPSQLIGFLLLWVPASRGEIVLTQSPDFQSVTPKEKVTITCRASQSIGSSLHWYQQKPDQSPKLLIKYASQSISGVPSRFSGSGSGTDFTLTINSLEAEDAAAYYCHQSSSLP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 6D-21.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: GRPE_STRS2
Sequence: MSEEIKNEEIVEEVEATEEVVETPEKSELDLANERAEEFENKYLRAHAEMQNIQRRANEERQTIQRYRSQDLAKKILPSLDNLERALQVEGLTEDVKKGLEMVQESLIQALKEEGVEEVATDVFDPNLHMAIQTVPATDDCPAEHIAQVFQKGYKLHERLLRPAMVVVSE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRAY_PARD8
Sequence: MLYYLFNYLDQLDFPGAGMFKYVSFRSGLALILSLFISTAIGRRIIDKLQMLQIGETVRNLGLEGQMSKKGTPTMGGIIIIIAILIPTLLCAKLNNIYVILMLVTTVWLGALGFADDYIKVFKKNKEGMHGRFKIVGQVGLGLIVGLVLFMSPDVVIKENMEVRHDNVIEEVRYHTVETKSTKTTIPFLKNNNFDYANLVNWAGDYKEEAAWLVFVLMVIFVVTAVSNGANMTDGLDGLAAGTSAIIGVALGILAYMSSHFEFASFLNIMFIPGAEELVVYAAAFIGATVGFLWYNSYPAQVFMGDTGSLTLGGIIAVFAIIIRKELLIPILCGIFLVENISVMLQVAYFKYTKKKYGEGRRIFKMAPLHHHFQKPGNAGIQALIQKPFNVVPESKIVVRFWLIGIILAVMTIVTLKMR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HEM1_SULDN
Sequence: MHYLNISFSHKNSTLDVREKLSYKDDYATKGCLSKLNSGESINESILISTCNRMEVFCSCSDIASATKHIFEMLAARSGVSIDELEGRADIFDDSSAIHHLFSVASSLDSMVIGETQIAGQLKDAFRFSYDNGFCSQKLARAMHHAFKCAAKVRNATDISSKPVSIASVAVSKLKSVLDNVEGKKALVIGVGEMSEITAKHLLSSGADVYITNRTKHKAEKLASECGAKVLDMQDLHKAVNEFEILFTATSSSEPIITDEIIKPCDFDRYWFDMAVPRDINYHKGDRINLYVVDDLKNIVDQNMSFREDGARKAHGIIGRSTVEFFEWLNTLNIEPMIKEIYEKAFEAARIESQRVIKKGFIPKEYEDQIHKMSQQVLKRFLHQMSSKMRSVSEESKADMLTSAVQFLIEKDQRDIPDKYKCEHALNIIEGR
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.