PharMolix/UniProtQA huggingface dataset:
Protein: KVD07_HUMAN
Sequence: MEPWKPQHSFFFLLLLWLPDTTGEIVMTQSPATLSLSPGERATLSCRASQSVSSSYLSWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTDFTLTISSLQPEDFAVYYCQQDYNLP
What is the function of this protein?
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447).  Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes.  In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells.  Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414).  The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain.  Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen.  The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).
What are the official names of this protein?
Immunoglobulin kappa variable 3D-7.
What are the subcellular locations of this protein?
Secreted. Cell membrane.
Protein: MED14_ASPNC
Sequence: MPGVVMDNANIGGLRHGPGNTYPQDGLSHSRGEVAQFNGANAQDGPVHVNGVEKNASQSRSVEAIPSNHASRVTKGPPELPHITQGFFPFAKLVNRSVQQCWNDLSDLITEMAEMQVNSHGIHPSTAPTTGKSPGNQSPGNIRKKLRILEFSHAKRAEFIKLLVLSQWSRQAADVSKLIDIQNFIRTRHQAYTNALQWVGDMKRDLVQAQVANPDLKTALEVLSRGKVASMSDLGYKPPRRLTVRGTLRKLQKINRLIGARLVVQDEIPPPFKSYRVHDGRVTFAVPGEFELDLSIGEENENSQFFFVDIRFLFSPSPPILKGRLLNELEMTINDVLQNSGLTGCFDLLHNLVLTNKINILFKQATELARSSWSDGLRVELLHRTLVVQYWTLKPGTKSWLEIGIKSGHRKSDSESPGLPSLKFRWVRDGGEVPCEDIAFDAKNLSMETVLRSVIALHVSHTLSSAYCKIRQSSLFSTGFLSLRAHLTRTEPGDCQLDVQLTETRHLQVSIEPMSGVSILSAKPTVSDRFDMERNPERSSVEDIVSRVARIRCNAAIEEIESKVKMLGFEPLNPRAWKLDIRRIFPPNFLRFTLFSHQLWGRSWIVAATSSMDGDSWWVVQLRPTLPAKGPPIPHANGYGQPILRSAQVVTDSFFPARYDIDDAYLANLGHSLSGILAIQSNARYLSDLQSIKFHPPPHKLKIEPDLRVPDILVRYDVSTLPSVFRVAMPAKAKKKSLIRDTIRLAFHGVDPREKCAIMVAYGNLVDSTATLCPLISSWDRSLVFQKGGTGFAMRLLAPAGHPVIVSLLENLQRLECVLSILETLQRKKVEIRTFSLSSISFIYGSERDLAASLNIHLSRNESLMKLSPTDLASRREFLFGLRLGIQFGLQNPHRRIQESLASSLNRSPTEAGLETVVELLTLTLPLMRALDQLMANPSHSGPLRLHVTVRNAKTYQLHYPGDEARFQLVAASHQNRLVWVLKDANSQGNSKNDDSITARLRQTLYTSKGDGWKGLETGVVAEVDQVGNLLRELEKCFVASRADRADPKHKPTDYAANHTGLNNPEISALAIKKGTTDGAKLSLSDSLTTLPNDKGNLSQADTAAQKEDIIMID
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 14, Mediator complex subunit 14.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 14 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CFI1_SOYBN
Sequence: YTGIGVYLEDKAVPSLAAKWKGKTSEELVHTLHFYRDIISGPFEKLIRGSKILPLAGAEYSKKVMENCVAHMKSVGTYGDAEAAAIEKFAEAFKNVNFAPGPLFLYRQSPDGILGLSFSEDVTIPEKEAAVIENKAVSAAVLETMIGEHAVSPDLKRILASRLLRIEHGIIV
What is the function of this protein?
Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones.  Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin (By similarity).
What are the official names of this protein?
Chalcone--flavanone isomerase 1, Chalcone isomerase 1.
What is the protein family that this protein belongs to?
Belongs to the chalcone isomerase family.
Protein: DLGD_SALPB
Sequence: MKVTFEELKGAFYRVLRSRNIAEDTADECAEMFARTTESGVYSHGVNRFPRFIQQLDNGDIIPDAKPQRVTSLGAIEQWDAKRAIGNLTAKKMMDRAIELASDHGIGLVALRNANHWMRGGSYGWQAAEKGYIGICWTNSIAVMPPWGAKECRIGTNPLIVAIPSTPITMVDMSMSMFSYGMLEVNRLAGRELPVDGGFDDNGQLTKEPGVIEKNRRILPMGYWKGSGLSIVLDMIATLLSNGSSVAEVTQENSDEYGVSQIFIAIEVDKLIDGATRDAKLQRIMDFITTAERADDNVAIRLPGHEFTKLLDDNRRHGITIDDSVWAKIQAL
What is the function of this protein?
Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
What are the official names of this protein?
2,3-diketo-L-gulonate reductase, 2,3-DKG reductase, 3-dehydro-L-gulonate 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYW_XYLFT
Sequence: MSIRVLTGITTSGTPHLGNYVGAIRPAIRAAGAPGTESFYFLADLHSLIKVQDPERTQRSTLEIAATWLACGLDPEKVWLYRQSDVPEITELMWLLTCVAGKGILNRAHAYKAVVDKNRSHGDDDDAGITAGLFMYPVLMAADILLFNAHQVPVGRDQIQHIEMARDFAQRFNHIYGGEYLVLPEAAIDEQVATLPGLDGRKMSKSYGNTMPLFCTREELKKYVFSIVTDSRAPGEPKEAVGSAVFQLYQAFAGVEECSMFAQALVEGLGWGEAKVRLFERIDAEVAPLRERYEDFMRRPADIEAMLRDSAGRLRERDAIPLLARLREAVGLRSLSLCMVSAVPVPQEKVALPVLKQYREQDGRFYFKLIDGQGAVLVQSRGFASPRDAGQWIALFKQVVSAEALVSPMLEPVADPVVVLAALRRLREAGLDLYT
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX3_ARTSA
Sequence: LSALLNTSILLRSGVTVTWAHHALMENNFDQCLQGLLFTVLLGLYFSFLQGLEYMEASFTIADSIYGSTFFLATGFHGLHVLIGTIFLMICILRHLSATFSQHHFGFEAAAWYWH
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SSRP_BACCQ
Sequence: MPKGSGKVIAQNKKAFHDYFIEETYEAGLVLQGTEIKSIRAGRVNLKDAFARVHNGEVWVHNMHISTYEQGNRFNHDPLRTRKLLLHKKEIDKLAGAAKETGYALVPLKIYLKNGFAKMALGLAKGKKQYDKRHDLKEKEAKREIARAFRDRQKM
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: M21_HRSVB
Sequence: MSRRNPCKFEIRGHCLNGRRCHYSHNYFEWPPHALLVRQNFMLNKILKSMDKSIDTLSEISGAAELDRTEEYALGIVGVLESYIGSINNITKQSACVAMSKLLIEINSDDIKKLRDNEEPNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSIIISNPKESTVNDQNDQTKNNDITG
What is the function of this protein?
Acts as a tetrameric transcription processivity factor that binds in a competitive manner to RNA and the phosphoprotein (P) to prevent premature termination during transcription.  Transcription anti-terminator that enhances readthrough of intergenic junctions during viral transcription.  Preferentially binds to poly(A)-rich sequences.  Plays a role in the association of the matrix protein with the nucleocapsid, which initiates assembly and budding.  Also, can activate host NF-kappa-B through association with host RELA.
What are the official names of this protein?
Protein M2-1, Envelope-associated 22 kDa protein, Transcription antitermination factor M2-1.
What is the protein family that this protein belongs to?
Belongs to the pneumoviridae M2-1 protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus. Note=Localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs). Forms a layer between the matrix and nucleocapsid.
Protein: CCA_STAAT
Sequence: MDKSLFEQARPILEQIQDNGFEAYYVGGSVRDYVMGRNIHDIDITTSATPDEIESIFSHTIPVGKEHGTINVVFNDENYEVTTFRAEEDYVDHRRPSGVTFVRDLYEDLQRRDFTMNAIAMDTAYKLYDYFDGQQDINNRIIRTVGIAEERFQEDALRMIRCLRFQSQLSFDIATETFEAMRIQMADIKFLSIERIVIELTKLMRGINVEKSFNHLKSLKAFNYMPYFEHLDMNQINVTEAIDLELLIAIVSVKFDINYSLKPLKLSNRQVKDINQYIQIMNALPSIITKEQLKMFVYDYDTHLIKNVMVAADVLKANDIQGHEPLIVNLQTIDETLHRLPMHNRKDMMVNGGVLMAHLNAKSGPWLKDVLRQIEIAIVTGKVSNEETEILKWVDNHVKI
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 3 subfamily.
Protein: RPOZ_LISMH
Sequence: MLYPSIDNLLLKIDSKYSLVTVAAKRARYMQLENDKGVLPSYQSDKFVGKALEEIHAGKLVLKNDDK
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PSTB2_STRPQ
Sequence: MTEYNWNERHIITFPEETLALATKDLHVYYGAKEAIKGIDMQFEKHKITALIGPSGCGKSTYLRSLNRMNDTIDIARVTGEILYQGIDVNRKDMNVYEIRKHLGMVFQRPNPFAKSIYKNITFAHERAGVKDKKVLDEIVETSLKQAALWDQVKDDLHKSAFTLSGGQQQRLCIARAISVKPDILLMDEPASALDPIATMQLEETMFELKKNYTIIIVTHNMQQAARASDYTAFFYLGNLIEYDKTRNIFQNAQCQSTNDYVSGHFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB 2, ABC phosphate transporter 2, Phosphate-transporting ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: LIPB_FRATT
Sequence: MNNIYQKDLGLQQYTKVFDDMLEFTSTRTPETNDEIWLVEHPAVFTQGKHGKPEHILNSHNIPIVATDRGGQVTYHGPGQAVIYFLLDIKRNKLGAKKLVTTVEQACINMLDKYYNLKAHIIDGAHGIYINNQKIASLGLRIKQGKSYHGIAINTNMDLTPFSYINPCGYSGLKMCQLANFYQEADIKKVQQQYTAEFVTLLNNSI
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_BOVIN
Sequence: MADDAGAAGGPGGPGGPGMGGRGGFRGGFGSGVRGRGRGRGRGRGRGRGARGGKAEDKEWLPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT
What is the function of this protein?
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules.  The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain.  The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity).  Plays a role in the assembly and function of the 40S ribosomal subunit.  Mutations in this protein affects the control of translational fidelity.  Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
What are the official names of this protein?
40S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus. Note=Probably localized to nucleolus and cytoplasm in complex with ZNF277.
Protein: PCP_HALH5
Sequence: MGNIILLTGFQPFLDYSINPTEAIVKELNGRKIGEYEVRGVILPVSFRESGDLLLHHFQTVQPTAVFMLGLAAGRGKITPERVAININSGPEDRDGIAPVDEPIRQGGPAAYFSTLPVRRLIQRLNEEGFPAEMSNSAGTYVCNHVMYRMLDYLHEKGSEQVAAGFVHLPASKELAAQHHSLPSMDLKDLTRAVTLMIEEL
What is the function of this protein?
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
What are the official names of this protein?
Pyrrolidone-carboxylate peptidase, 5-oxoprolyl-peptidase, Pyroglutamyl-peptidase I, PGP-I, Pyrase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C15 family.
Protein: RR3_NEOYE
Sequence: MGQKIHPLGFRIGITQKHRSSWFANSKDYPVLLQEDHKIRSFIHSKLSNASIAKIEINRKVDQVEILIATARPGIVLGKSGAGIESLRKSLSLILDPSKQLRVNVVEIADPDSEATLVAEFITQQLEKRVAFRRAVRQAVQRAQRANTQGVKIQVSGRLNGAEIARSEWVREGRVPLQTLRADIDYCHRQAHTTYGVLGVKVWLFKGEILPESKSLESAYNQETPDSTAS
What are the official names of this protein?
30S ribosomal protein S3, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: SP5G_ACHLI
Sequence: MKITDVRVRHVSSDSRLKGVVTITFEDAFVVHDIRVIEGENGLFVAMPSKKMPNGGFRDIAHPIHADMRKQIEDSIIKAYKETLDAEATASVEE
What is the function of this protein?
Could be involved in septation.
What are the official names of this protein?
Putative septation protein SpoVG.
What is the protein family that this protein belongs to?
Belongs to the SpoVG family.
Protein: PHCB2_SYNP6
Sequence: MTFDAFTKVVAQADARGEFLSDAQLDALSRLVAEGNKRIDTVNRITGNASSIVANAARALFAEQPSLIAPGGNVYTNRRMAACLRDMEIILRYVTYAVFTGDASILDDRCLNGLRETYLALGVPGASVAEGVRKMKDAAVAIVSDRNGITQGDCSAIISELGSYFDKAAAAVA
What is the function of this protein?
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex (phycobilisome, PBS).  Phycocyanin is the major phycobiliprotein in the PBS rod.
What are the official names of this protein?
C-phycocyanin-2 beta subunit.
What is the protein family that this protein belongs to?
Belongs to the phycobiliprotein family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side. Note=Part of the phycobilisome rod.
Protein: TUSA_TOLAT
Sequence: MTFSADDINQTLDASGLRCPEPVMMVRKTVRLMQEGETLLVIADDPATVRDIPSFCRFMDHTLLASDTEQPPYRYLIRKGLN
What is the function of this protein?
Sulfur carrier protein which probably makes part of a sulfur-relay system.
What are the official names of this protein?
Sulfur carrier protein TusA.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPD_GRAFK
Sequence: MRGTRAAQRYAKAILSLAKDKNSAEAVNEDMISISKTVVNSRDLENMLTSPVIKDSTKKSALLEIFKDLNTITKGAIDILLENGRIGILHLVARQYIIKFNELNNVRQAVVTTAVPLDKELEAVILSKVKELTGSEASLKSVIDEDIIGGFVLRVGDLQYDASVSRNLRRLERELKDNTYVSKI
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RBL_CARCO
Sequence: MSPQTETKASVGFKAGVKDYKLTYHTPDYETKDTDILAAFRVTPQPGVPAEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVAGEESQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYTKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDYIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEIIRAAAKWSPELAAACEVWKEIKFEFPAMDTL
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: DMBX1_HUMAN
Sequence: MQHYGVNGYSLHAMNSLSAMYNLHQQAAQQAQHAPDYRPSVHALTLAERLAGCTFQDIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDTQLDTEQPPRLPGSDPPAELHLSLSEQSASESAPEDQPDREEDPRAGAEDPKAEKSPGADSKGLGCKRGSPKADSPGSLTITPVAPGGGLLGPSHSYSSSPLSLFRLQEQFRQHMAATNNLVHYSSFEVGGPAPAAAAAAAAVPYLGVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLLPAPPAGLAPASATLNSKTTSIENLRLRAKQHAASLGLDTLPN
What is the function of this protein?
Functions as a transcriptional repressor.  May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence.  Required for brain development (By similarity).
What are the official names of this protein?
Diencephalon/mesencephalon homeobox protein 1, Orthodenticle homolog 3, Paired-like homeobox protein DMBX1.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PRKY_HUMAN
Sequence: MEAPGPAQAAAAESNSREVTEDAADWAPALCPSPEARSPEAPAYRLQDCDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKLYFPRHLDFHVKTGRMM
What are the official names of this protein?
Putative serine/threonine-protein kinase PRKY.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Protein: ASCD_ACREG
Sequence: MSAIPKKCTVLVIGGGPGGSYAASALAREGIDTVVLEGDKFPRYHIGESMLASMRHLLKFVELDGKFDSYGFVKKPGAAFKLNKNKREGYTDFLAAGGPNNYAWNVVRSEADNLMFQHAGESGAKIFDGVSVKSIQFENPTEVPDGEPNLNPGKPVSATYQIKETKEQGQIDFDYVVDASGRIGILSTKYMKNRRYNQGLKNIANWGYWEGCNKYAPGTPRENSPFFEALQDESGWAWFIPLHNGTVSVGVVMNQKLATQKKQEADLDSTEFYHDTLNKISPNLRELIGDGKFVSNVKTASDYSYSASSYSFPYARIVGDAGCFIDPYFSSGVHLALTSGLSAATTISASIRGQVDEELGSEWHTKKFSDAYTRFLLVVLSAYKQIRHQEEPVLSDFDEDNFDRAFSFFRPIIQGTADAANNKLSQEELNKTLEFCAFAFEPVENDEDRSKAMSAMQEAVDNGTGYHPDLSPEQLKAVKHIQARRAMRTSDTMNIESFGTDAINGFVPNLVRGSLGLRKQEAMSGDMGGANGHVDETNGVTVNGHHQPEGVKAH
What is the function of this protein?
Flavin-dependent halogenase; part of the asc-1 gene cluster that mediates the biosynthesis of both ascochlorin and ascofuranone, a strong inhibitor of cyanide-insensitive alternative oxidases and a promising drug candidate against African trypanosomiasis (PubMed:30952781, PubMed:35418536).  The first step in the pathway is performed by the non-reducing polyketide synthase ascC that produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:30952781, PubMed:35418536).  Orsellinic acid is then prenylated by the prenyltransferase ascA to yield ilicicolinic acid B (PubMed:30952781, PubMed:35418536).  Ilicicolinic acid B is further reduced to ilicicolin B by the reductase ascB (PubMed:30952781, PubMed:35418536).  The halogenase ascD then chlorinates ilicicolin B to produce ilicicolin A which is converted to ilicicolin A epoxide by the cytochrome P450 monooxygenase ascE that catalyzes stereoselective epoxidation of the terminal double bond of the prenyl group (PubMed:30952781, PubMed:35418536).  Ilicicolin A epoxide is the last common precursor for the biosynthesis of ascofuranone and ascochlorin (PubMed:30952781, PubMed:35418536).  The terpene cyclase ascF produces a monocyclic terpene, and the cyclization reaction is proposed to be initiated by protonation of the terminal epoxide of ilicicolin A epoxide to generate a monocyclic tertiarycation, which is followed by a series of hydride and methyl shifts with abstraction of proton, leading to the formation of the (14S,15R,19R)-trimethylcyclohexanone ring structure of ilicicolin C, which is finally reduced to ascochlorin by the dehydrogenase ascG (PubMed:30952781).  On the other hand, ilicicolin A epoxide is hydroxylated by the cytochrome P450 monooxygenase ascH, and the resultant product is cyclized by the terpene cyclase ascI to ascofuranol via protonation-initiated epoxide ring opening, which facilitates the 6-endo-tet cyclization to form the tetrahy-drofuran ring (PubMed:30952781, PubMed:35418536).  Finally, ascofuranol is oxidized into ascofuranone by ascJ (PubMed:30952781, PubMed:35418536).
What are the official names of this protein?
Flavin-dependent halogenase ascD, Ascofuranone/ascochlorin biosynthesis clusters protein D.
What is the protein family that this protein belongs to?
Belongs to the flavin-dependent halogenase family.