PharMolix/UniProtQA huggingface dataset:
Protein: INSI2_MOUSE
Sequence: MAEGETESPRPKKCGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVITSIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE
What is the function of this protein?
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:12624180, PubMed:16100574).  Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:16100574).  Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum (By similarity).  In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi (By similarity).  Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity).  Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase RNF139 (By similarity).
What are the official names of this protein?
Insulin-induced gene 2 protein, INSIG-2.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ACPS_MYCBO
Sequence: MGIVGVGIDLVSIPDFAEQVDQPGTVFAETFTPGERRDASDKSSSAARHLAARWAAKEAVIKAWSGSRFAQRPVLPEDIHRDIEVVTDMWGRPRVRLTGAIAEYLADVTIHVSLTHEGDTAAAVAILEAP
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNME_RICTY
Sequence: METIFAQSSAFGKAGVAVFRISGPKSLEVLQLLTGRKDFKPRLMYYQQIISPETNELIDNAMVVYFKLPNSFTGEDVVEIHTHGSKAISIMLINTLLNIDDIRLAEAGEFTKRAFLNNKFDLTAAEGIADLINAETIMQHRQAVRQANGGLEELYNNWRNQLLKIIALLEAYLDFPDEDIPDSILNDVNNTHKNIVNEISNYLNDNRRGELLNNGLKLAIIGPPNTGKSSLLNFLMQRNIAIVSNIAGTTRDIIEGHLDIGGYPIILQDTAGIRAESTDIIEREGIKRAINSAKTANIKIIMFDAEKLDLSINNDIIDLIDENTIVIINKIDLIEPSQIFPIEKKYKCLRVSVKNNIALSSILKNIENIAENIAGFTETPYITNQRHRHYLKQALSHLMAFNLDNDLVLATEDMRMTARCIGLITGVINVEEILNEIFKNFCIGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PG170_VACCC
Sequence: MYSLLFIILMCIPFSFQTVYDDKSVCDSDNKEYMGIEVYVEATLDEPLRQTTCESEIHKYGASVSNGGLNISVDLLNCFLNFHTVGVYTNRDTVYAKFASLDPWTTEPINSMTHDDLVKLTEECIVDIYLKCEVDKTKDFMKTNGNRLKPRDFKTVPPSDVGSMIELQSDYCVNDVTAYVKIYDECGNIKQHSIPTLRDYFTTKNGQPRKILKKKFDNC
What is the function of this protein?
May interact with several cellular chemokines to interfere with chemokine-glycosaminoglycan (GAG) interactions at the cell surface to alter chemotaxis of nearby responsive cells.
What are the official names of this protein?
Protein OPG170.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG170 family.
Protein: NRFA_ECO45
Sequence: MTRIKINARRIFSLLIPFFFFTSVHAEQTAAPATPVTVEAKNETFAPQHPDQYLSWKATSEQSERVDALAEDPRLVILWAGYPFSRDYNKPRGHAFAVTDVRETLRTGAPKNAEDGPLPMACWSCKSPDVARLIQKDGEDGYFHGKWARGGPEIVNNLGCADCHNTASPEFAKGKPELTLSRPYAARAMEAIGKPFEKAGRFDQQSMVCGQCHVEYYFDGKNKAVKFPWDDGMKVENMEQYYDKIAFSDWTNSLSKTPMLKAQHPEYETWTAGIHGKNNVTCIDCHMPKVQNAEGKLYTDHKIGNPFDNFAQTCANCHTQDKAALQKVVAERKQSINDLKIKVEDQLVHAHFEAKAALDAGATEAEMKPIQDDIRHAQWRWDLAIASHGIHMHAPEEGLRMLGTAMDKAADARTKLARLLATKGITHEIQIPDISTKEKAQQAIGLNMEQIKAEKQDFIKTVIPQWEEQARKNGLLSQ
What is the function of this protein?
Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process.
What are the official names of this protein?
Cytochrome c-552, Ammonia-forming cytochrome c nitrite reductase, Cytochrome c nitrite reductase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c-552 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: CARB_BACC2
Sequence: MPKRLDINTILVIGSGPIVIGQAAEFDYSGTQACQSLREEGYKVILVNSNPATIMTDTATADKVYIEPLTLEFVSRIIRKERPDAILPTLGGQTGLNMAVELAKSGILEECGVEILGTKLSAIEQAEDRDLFRTLMQELNEPIPSSTIIHTLEEAHEFVKEIGYPVIVRPAFTMGGTGGGICSNEEELIEIVSGGLKHSPVTQCLLEKSIAGCKEIEYEVMRDSNDNAIVVCNMENIDPVGVHTGDSIVVAPSQTLSDREYQMLRNTSLRIIRALGIEGGCNVQLALDPHSFQYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEIINPVTQKTYACFEPALDYVVSKIPRWPFDKFESANRTLGTQMKATGEVMSIGRNLEQSLLKAVRSLELGVYHLELEHLKELDKETMKKRIIKADDERLFIVAEAIRQGVTKEEINEWCEMDFFFLQKVENIVNMEREVKANVGNMEVLQTAKEMGFSDHYVAAAWNKTEREIYDMRKESNITPVYKMVDTCAAEFESATPYYYSTYGDENESVRTDRKSVVVLGSGPIRIGQGVEFDYATVHSVWAIKEAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDLEKPEGVIVQFGGQTAINLAAKLEEHGVKILGTSLEDLDRAEDRDKFEAALTQLGIPQPVGKTATTVEQAVAIAEEIGYPVLVRPSYVLGGRAMEIVYRQEELLHYMKNAVKVHAEHPVLIDRYMVGKEIEVDAISDGENVFIPGIMEHIERAGVHSGDSIGVYPPQSLSEKLKEQIIEHTIALGKGLNIVGLLNIQFVVFKDQVYVIEVNPRASRTVPFLSKITGVPMANVATKVILGQDLVEQGYGTGYHPEEKEVYVKAPVFSFAKLRSVDTTLGPEMKSTGEVMGKDLTLEKALYKGLVASGINIPTHGSVIITVADKDKEEAMEIAKRFHEIGYNLLATAGTAQSLAEQNIPVQVVNKIDSEDYNLLDIIRQGKAQFVINTLTKGKQPARDGFRIRRESVENGVACLTSLDTTRAILRVLESMTFSAHSMKEITQTKRHEVVHA
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.
Protein: PYRD_ARATH
Sequence: MAGRAATSSAKWAREFLFRRVSSNPLGATRNCSSVPGASSAPKVPHFSKRGRILTGATIGLAIAGGAYVSTADEATFCGWLFNATKVVNPFFALLDAEFAHKLAVSAAARGWVPREKRPDPAILGLEVWGRKFSNPIGLAAGFDKNAEATEGLLGMGFGFVEVGSVTPVPQEGNPKPRIFRLSQEGAIINRCGFNSEGIVVVAKRLGAQHGKRMLAETSATSSSPSDDVKPGGKSGPGILGVNLGKNKTSEDAAADYVQGVHNLSQYADYLVINVSSPNTAGLRMLQGRKQLKDLVKKVQAARDEMQWGDEGPPPLLVKIAPDLSRGELEDIAAVALALHLDGLIISNTTVSRPDAVSNNPVATETGGLSGKPLFALSTNMLRDMYTLTRGKIPLIGCGGVSSGEDAYKKIRAGATLVQLYTGFAYGGPALIPQIKEELVKCLERDGFKSIHEAIGADHR
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOdehase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: BIOD_NEIMB
Sequence: MKGVYFVSGIDTDIGKTVATGVLAKQLLQQGKSVITQKPVQTGCQNIADDIAVHRKIMGIPMQEADKRRLTMPEIFSYPASPHLAARLDGRALDLDKIRTATQELAAQYEVVLVEGAGGLMVPLTENLLTIDYIRQQGYPVILVTSGRLGSINHTLLSFAALKQYGIRLHSLVFNHIHDSRDAHIAQDSLSYLKCRLKADFSEAEWMELAKTDAV
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSUB1_STRAW
Sequence: MATDVHRPLSTQKAATAAAQASTAAASAVRVDGLTRSFDGRAVIDNLELDVRPGEFVALLGRSGCGKSTLLRILAGLDRDIEGTVLVPRRKAVAFQAPRLMPWKKVWRNVLLGLPGKPERAVAEQALTEVGLAHRSHAWPKTLSGGEAQRASLARALVREPDLLLLDEPFGALDALTRIKAQRLVGELWQRRGCAVLLVTHDVEEAVLLADRVLVMDDGVIAYETEVELDRPRDITDPRFAELRAELLERLGVDTAAEAA
What is the function of this protein?
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Aliphatic sulfonates import ATP-binding protein SsuB 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: THIKB_CANTR
Sequence: MDRLNQLSGQLKPNAKQSILQKNPDDVVIVAAYRTAIGKGFKGSFRNVHSEFILTEFLKEFIKKTNIDPSLIEDVAIGNVLNQAAGATEHRGACLAAGIPYTAAFIAVNRFCSSGLMAISDIANKIKTGEIECGLAGGAESMSTNYRDPRVAPRIDPHLADDAQMEKCLIPMGITNENVANQFNISRERQDEFAAKSYNKAAKAVASGAFKSEILPIRSIIRNSDGTEKEIIVDTDEGPREGVTAESLGKLRPAFDGTTTAGNASQVSDGAAAVLLMKRSLAEAKGYPIIGKYVLCSTAGVPPEIMGVGPAFAIPEVLKRTGLTVDDIDVFEINEAFAAQCLYSAEQVNVPEEKLNINGGAIALGHPLGETGARQYATIIPLLKPGQIGLTSMCIGSGMGSASILVRE
What are the official names of this protein?
3-ketoacyl-CoA thiolase B, peroxisomal, Acetyl-CoA acyltransferase B, Beta-ketothiolase B, Peroxisomal 3-oxoacyl-CoA thiolase B, Thiolase IB.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: OTCC_BACC1
Sequence: MLMTRPNLKGRSFLAEKDFTQEELLYFLDLAAELKEKKKNGIPHHYLEGKNVALLFEKTSTRTRCAFTVACTDLGANPEYLGKSDIQLGKKESVEDTAKVLGRMFDGIEFRGFNHETVESLAQNSGVPVWNGLTDMWHPTQTLADLLTIREHVGKLKNVKLVYVGDGRNNVANSLLVGGAIVGMDVRICTPETLWPAQEVIDLAKKYNEQVMITSNVEEAVANADVIYTDVWVSMGEEEKFAERVKLLKPYQVNMKMIKETGNENVIFLHCLPAFHDVETMYGEEVYEKYGLKEMEVTDEVFRSKHSKVFDQAENRMHTIKAVMAATLGNME
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, catabolic, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSB_ECO55
Sequence: MSFVVIIPARYASTRLPGKPLVDINGKPMIVHVLERARESGADRIIVATDHEDVARAVEAAGGEVCMTRADHQSGTERLAEVVEKCAFSDDTVIVNVQGDEPMIPATIIRQVADNLAQRQVGMATLAVPIHNAEEAFNPNAVKVVLDAEGYALYFSRATIPWDRDRFAEGLETVGDNFLRHLGIYGYRAGFIRRYVNWQPSPLEHIEMLEQLRVLWYGEKIHVAVAQEVPGTGVDTPEDLERVRAEMR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_MYCTU
Sequence: MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring (PubMed:20565114).  Can use a range of NTPs; has highest affinity for CTP (KD is measured as 17. 2 uM or 0. 160 uM in 2 different papers) while KD for ATP is 331 uM or 75 uM in the same papers.  Gly-169 plays a role in NTP discrimination (PubMed:25801336, Ref. 5).
What are the official names of this protein?
Dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPRD_HUMAN
Sequence: MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSFESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIMLIYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACSPEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
What is the function of this protein?
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes.  Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
What are the official names of this protein?
Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type I membrane protein.
Protein: HPCH_SHISS
Sequence: MENSFKAALKAGRPQIGLWLGLSSSYSAELLAGAGFDWLLIDGEHTPNNVQTVLTQLQAIAPYPSQPVVRPSWNDPVQIKQLLDVGTQTLLVPMVQNADEAREAVRATRYPPAGIRGVGSALARASRWNRIPDYLQKANDQMCVLVQIETREAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIREAGKAPGILIANEQLAKRYLELGALFVAVGVDTTLLARAAEALAARFGAQATAVKPGVY
What is the function of this protein?
Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.
What are the official names of this protein?
4-hydroxy-2-oxo-heptane-1,7-dioate aldolase, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, HHED aldolase, 4-hydroxy-2-ketoheptane-1,7-dioate aldolase, HKHD aldolase.
What is the protein family that this protein belongs to?
Belongs to the HpcH/HpaI aldolase family.
Protein: RLMG_VIBC3
Sequence: MKTELTLLEQTLTLHRFPKRNNETLQAWDAGDEYLIQHVEQLALPESSHIVIINDHFGTLSCWFSQKHKVSMMSDSYIAHQATQANLQQNQRPPVQLLTTLDPVPNDASVVLLQLPKSNRHLVWILSQLRKALSPNIPIIAVNKAKEIHTSTLNLFEKHLGPTTTSLAWKKHRLVFSSATVNPANEVNPECGWSIEPYAITLTNLPNVYSGESLDLGSRFILEHLPADPTLEDFIDLGCGNGVLSVRLGQLNPQAKITCVDESFMAIASAQKNLHDNLGKRDIHCIANNCLDGFPAHSSSMIVCNPPFHQQQTITDHIAWQMFCDSKHVLKKGGKLWVIGNRHLGYDVKLARLFGKSHVRVIANNSKFVILQAIKS
What is the function of this protein?
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase G, 23S rRNA m2G1835 methyltransferase, rRNA (guanine-N(2)-)-methyltransferase RlmG.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VNUN_BPHK0
Sequence: MLMVKKTIYVNPDSGQNRKVSDRGLTSRDRRRIARWEKRIAYALKNGVTPGFNAIDDGPEYKINEDPMDKVDKALATPFPRDVEKIEDEKYEDVMHRVVNHAHQRNPNKKWS
What are the official names of this protein?
Transcription termination factor nun.
Protein: NAPA_HELHP
Sequence: MTSKIQGKKPTLSRRDFIKSAAAASAAASVGLSIPSVMSAEAQNAQKLWKWDKSVCRFCGTGCGIMVATQKDNTGQAKIVAIKGDPEAPVNRGLNCIKGYFCAKIMYGADRLTTPLLRVNSNGEFDKKGKFAPVSWKRAFDEMEKQFKKAYNELGPTGIAVFGSGQYTIQEGYAAVKLVKGGFRSNNIDPNARHCMASAVVGFMETFGIDEPAGCYDDIELTDTIVTWGANMAEMHPVLWSRVTDRKLSSSNVKVINLSTYTNRTSDLADIEIIFKPHTDLAIWNFLAREIINRNAVDEAFVKENCVFSTGFVNIGYGMRNNPQHPKFKPEERDIVAKEVSKIVSNDEGITLQYLGIKAGEEMKMDKAGAAGNHWGISFEDFKKGLEPYTLDFVANLAKGNPDESIESFKQKLQSLADYYIDKNRKIVSFWTMGMNQHQRGTWVNEQSYMVHMLLGKQAKPGSGAFSLTGQPSACGTAREVGTFSHRLPADMVVANPKHREITEKIWHLPSGTLNSKIGAPYLKIMRDLEDGNIKWAWVQVNNPWQNTANANHWIAAAREQDNFIVVSECYPGISAKVADLILPTAMIYEKWGAYGNAERRTQHWKQQVVAPGEAMPDIWQMAEFAKRFKLSEVWDKGYEALDIKPVLESAKAMGYTEEDTLFDVLFANKNAKNFSAQDALLKNEFNTEVLGDSRNVEDGNGEAFKGYGFFIQKYLWEEYRQFGLGHAHDLADFDTYHRVRGLRWPVVNGKETQWRFNAKYDFYAQKLGNGKAFAFYGNKGKDMPAGSLNAPSEEKVSIDNKAKIFLRPYMDPCEMPDKEYPMWLCTGRVLEHWHSGTMTMRVPELYRAVPEALCYMHPDDANAQNLEQNQVVWVESRRGKVKAKLDLRGRNRPPKGLIYVPWFDENVFINKVCLDATCPISKQTDFKKCAVKVYKA
What is the function of this protein?
Catalytic subunit of the periplasmic nitrate reductase complex NapAB.  Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
What are the official names of this protein?
Periplasmic nitrate reductase.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: MUTS_CHLMU
Sequence: MTQKLTPMMQQWHQCKEQAGDCLLLFRLGEFYEAFFDDALVLAQNLDITLTQRQNIPMSGIPAAYLDGYVDRLVSRGFKIAIAEQADNSEGGKGLVPRTINRLITPGALLSSSLLPEKANNYIIAISQVGSLYGLSCLDLSTGTFLVAEYDNTKDLIEAVYRLAPTELLSHAKFYQKNEPVVKQLQQHLRITLSEHVSWAFEYQSATKKLYTCFQVSSLDGFGLQGLVPAINAAGALLSYIQDKLLLPISHLSIPKIYGQHKHLLIDKASQTNLELLSAIHGEHGKGSLLQVMERTSTPMGGRLLRNTLVNPFYDLKEITLRQDSVEFFLKQEPLRKTLKRHLSCVRDLERLATKISTTLASPKDIGMLRDSLLSCMHIAHDLQSYTLPEFLTNKCLISSSLKSLIEALSTDLLQELPLKVSEGNIFADHYHQDLLRLRNIKTNSKSWILEYQERIRQETGIKKLKVCYAQALGYYIEVASSFAPQLPKEFIRRQSRLHAERFTTQELQQFQDEVFSVEDKLQTLETKLFKELCCYILQHRDLILELSTTIADLDYVISLAELAAEYDYRRPLVDHSDALSITKGMHPVALTLLDRGTFIPNDTIMHSAQTRMILLTGPNMAGKSTYIRQIALLVIMAQMGSFIPARSAHIGIIDKIFTRIGAGDNLSKGMSTFMVEMAETANILHNATDRSLVILDEVGRGTSTYDGLAIAQAVVEFLLFTEGKKAKTLFATHYKELTELELHCQHVENFHAVVKENGGQPVFMYEIAKGHSKKSFGIHVAKLAGFPLSVVSRAQQILHQFEGPDLRPEPEKAQQLVMF
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is possible that it carries out the mismatch recognition step.  This protein has a weak ATPase activity (By similarity).
What are the official names of this protein?
DNA mismatch repair protein MutS.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
Protein: GSA_METHJ
Sequence: MSEKSREYYTIARDLMPGGVSSPVRAIQPYPFYTVRGSGSRIYTVDGTELIDCCGAYGPLILGHACKPVGDAISSALDDGWLYGTPTPAEIDLAQILIADHPSIEMVRFVTTGSEATMAAIRLARGYTGKSDIIKTEGGFHGAHDGVLVQAGSGCTTLGQPDSAGVLSDIVRHTRQVPYNDTESLISLVDKSGDEIAAMILEPVMGNIGPVLPKPGYLQEVRKITAEHDILLIFDEVITGYRVGIGGAQKLFGVTPDITTLGKIIGGGLPLSAFGGKRKIMELIAPAGPVYQAGTFSGNPLSLAAGVAALREIHARKGMYTLLDTATTVIGEACQGKGGSFVKLGSMFKFFFRSSVPENYAQAKESDTTKFRAFWEKMLEKGIFLPPSQFETNFLSAAHSDSDVEYLSSAYASCLSA
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase, GSA, Glutamate-1-semialdehyde aminotransferase, GSA-AT.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GON3_PETMA
Sequence: QHWSHDWKPG
What is the function of this protein?
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
What are the official names of this protein?
Gonadoliberin-3, Gonadoliberin III, Gonadotropin-releasing hormone III, GnRH-III, Luliberin III.
What is the protein family that this protein belongs to?
Belongs to the GnRH family.
What are the subcellular locations of this protein?
Secreted.
Protein: MENH_HAEIN
Sequence: MINIIFLHGLLGTKNDWQKVIENLPHFNCIALDLPFHGQAKDLEVTNFEDSAEYLAQQIKSAVKNGPYFLVGYSLGGRIALYYALQAQLERSNLQGVILEGANLGLKTDEEKQARFQQDFAWAQRFMQESPEKVLNDWYQQPVFSHLTTEERLQLVEKRKSNCGKNIGKMLLATSLSKQPDFSEKVRLSSLPFFYFCGERDHKFQVLAKENQIDLVTIPCAGHNSHLENSKYFSKKIENCILKIVRP
What is the function of this protein?
Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
What are the official names of this protein?
Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, SHCHC synthase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MenH family.
Protein: ACKA_SHEB2
Sequence: MSNNLVLVLNCGSSSLKFAVIDAQTGDDQISGLAECFGLEDSRIKWKINGEKHEAALGAFTAHREAVEYIVNKILAEQPELAAKIQAVGHRIVHGGEKFTRSVIIDESVIKGIEDCASLAPLHNPAHLIGIRAAIASFPKLPQVAVFDTAFHQSMPDRAYVYALPYKLYREHGIRRYGMHGTSHLFVSREAAKMLNKPIEETNVICAHLGNGASVTAIKGGKSVDTSMGLTPLEGLVMGTRCGDIDPSIIYHLVHQLGYTLEEVNNLMNKQSGLLGISELTNDCRGIEEGYADGHKGATLALEIFCYRLAKYIASYTVPLGRLDAVVFTGGIGENSDLIREKVLNMLEIFNFHVDSERNKAARFGKKGIITQDKGTIAMVIPTNEEWVIAEDSIKLINK
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_NEIM0
Sequence: MRHRNGNRKLNRTSSHRAAMLRNMANSLLTHEAIVTTLPKAKELRRVVEPLITLGKKPSLANRRLAFDRTRDRDVVVKLFGDLGPRFTARNGGYVRVLKYGFRKGDNAPLALVELVDKPAAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: DPO3_STAHJ
Sequence: MAMTNQEKFKVLADQIKVSNQLDQTIIEKGELTRVDVSNKNRTWEFQITLPYFLSHEDYLIFTNAITEEFKEIAKVDWHFTIQDTSNQDEHAIKYFGHCIEHTALSPKVKGQLKQKRLIMSGNVLKVMTSNDIERNHFDKVCNGSLVKAFRKCGFDIDKVVFETDDSSSYDDLASLEAHIQEEDEKSAREATEKIEKIKAEKAKQQDNNESNVDKCQIGKPIQIDNIKPIESIIEEEFKVAIEGVIFDINLKELKSGRHIVELKVTDYTDSLVLKMFTRKNKDDLDHFKALSVGKWVRAQGRIEEDTFVRDLVMMMTDIEEIKKTPKQDKAEEKRVEFHLHTSMSQMDGIPNISAYVNQAAKWGHKAIAVTDHNVVQAFPDAHGAAEKNGIKMIYGMEGMLVDDGVPIAYKPTDRDLKEATYVVFDVETTGLSNQYDQIIELAAVKVKDGEIIDKFERFSNPHEKLSETIINLTHITDDMLTDAPEIEEVLTEFKEWVGDAIFVAHNASFDMGFIDTGYERLGFGPSTNGVIDTLELSRTINTEYGKHGLNFLAKKYGVELTQHHRAIYDTESTAYIFIKMVQQMKELGVTNHKDINQKLSNEDAYKRARPTHVTLIVQTQEGLKNLFKIVSASLVKYYYRTPRIPRSLLNEYREGILVGTACDEGELFTAVMQRDQSEVEKIAKYYDFIEVQPPKLYQDLIDRELIRDTETLYEIYERILKAGESTGIPVIATGNAHYLYEHDAIARKILIASQPGNPLNRSTLPEAHFRTTDEMLDEFHFLGEEKAHEIVVKNTNELADRIEKVIPIKDQLFTPRMDGANEEIRELSYTNAKKLYGEDLPQIVIDRLEKELASIIGNGFSVIYLISQRLVKKSLDDGYLVGSRGSVGSSFVATMTEITEVNPLPPHYICPNCKTSEFFDDGSVGSGFDLPDKQCSTCGAELIKEGQDIPFETFLGFKGDKVPDIDLNFSGEYQPNAHNYTKVLFGEDKVFRAGTIGTVAEKTAFGYVKGYLNDQGIHKRGAEIDRLVKGCTGVKRTTGQHPGGIIVVPDYMDIYDFTPIQYPADDQSASWMTTHFDFHSIHDNVLKLDILGHDDPTMIRMLQDLSGIDPKTIPVDDKETMQIFSSPESLGVTEEEILCKTGTFGVPEFGTGFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIRSGICDLSSVIGCRDDIMVYLMYAGLEPSMAFKTMESVRKGKGLTEEMIDAMKENNVPDWYLDSCLKIKYMFPKAHAAAYVLMAVRIAYFKVHHPLYYYASYFTIRASDFDLITMIKDKESIKNTVKDMYSRYMDLGKKEKDVLTVLEIMNEMAHRGFRMQPISLEKSQAFDFIIEGDTLIPPFISVPGLGENVAKRIVEAREDGPFLSKEDLNKKAGLSQKIIEYLDDLGSLPNLPDKAQLSIFDM
What is the function of this protein?
Required for replicative DNA synthesis.  This DNA polymerase also exhibits 3' to 5' exonuclease activity.
What are the official names of this protein?
DNA polymerase III PolC-type, PolIII.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-C family. PolC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTS_SALRD
Sequence: MSVSAKQVKELRDATGVGMMDCKEALQETDGDFDEAVSLLRKKGQEVADDRAAVEADEGLVVTAVSDDGHAGAIVEINCETDFVARNEDFQSFADTAAERVLEETPDDLEALESLPYEDDVTIEEELVALTGRIGEKLTIRRFDVLESEEGQIISYVHPGSKLGVLVEVHGDGEAEETGRDVAMQVAALEPIAVTRDEVPDEVKEEEREVAREAAVNEGKPEHVIDNIVEGKLERFFEDHVLMEQAFVKDSSVSVKDMLDDADLSVARFTRYALGD
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome.
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.