PharMolix/UniProtQA huggingface dataset:
Protein: RL23_PHYAS
Sequence: MKYYDLIKSPIVTEVTNKLIERQNKYTFKVAKTANKIEIKKAFEHIFKVKVTVNTSNVLPRFKRKGKYAGYTAGYKKAVVKVTSGEKIAILAND
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PRX1_PENRW
Sequence: MANPLISNHHGKNGKYTQAFLEQNGPGDARPTALDILKDNDRIDSMKDKVFLLTGSSGGIGIETGRALAATGGKVYLGVRDLEKGKQALEEILEPGRVELLELDIGSMESVRTAAKTFLSKSTQLNVLVNNAGIMACSEAKTADGFESQLAINYLGHFLLYKLLEQTLLSSSTPEFQSRVVNVSSAGHHMSSVVLDNINLEGEYEEWKAYGNAKTACIWMTNEIEHRYGSKGLHGLSLMPGGIATGLQRHVDPETLKQWGSSEPAQKYGKSSAQGAATTITAAFGKEWEGKGGVYLEDCQEAGPVPEGGTLAVGVAPHAFDPEGEKKLWDLSLKMLDLSE
What is the function of this protein?
Short-chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase prx9 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699) (By similarity).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase prx11 (By similarity).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, eremofortin A is converted to eremofortin C and then to PR-toxin (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:24239699).  The cytochrome P450 monooxygenase prx8 also plays a role in this step (By similarity).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:24239699).
What are the official names of this protein?
Short-chain dehydrogenase/reductase prx1, PR-toxin biosynthesis cluster protein 1.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: HBA_PILBA
Sequence: MVLSPADKTNVKTAWGKVGGHGGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTLAAAHVDDMPSALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHHPAEFTPAVHASLDKFLASVSTVLTSKYR
What is the function of this protein?
Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1.  Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.
What are the official names of this protein?
Hemoglobin subunit alpha, Alpha-globin, Hemoglobin alpha chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: TBB_CHLRE
Sequence: MREIVHIQGGQCGNQIGAKFWEVVSDEHGIDPTGTYHGDSDLQLERINVYFNEATGGRYVPRAILMDLEPGTMDSVRSGPYGQIFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVVPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPTFGDLNHLISAVMSGITCCLRFPGQLNADLRKLAVNLIPFPRLHFFMVGFTPLTSRGSQQYRALTVPELTQQMWDAKNMMCAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNVKSSVCDIPPKGLKMSATFIGNSTAIQEMFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDASAEEEGEFEGEEEEA
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-1/beta-2 chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: ATP6_RICAH
Sequence: MTHSPLAQFDIKKLIDIKMFGFDISFTNSSIYMLLASILALTYFYLAFYNRKLVPSRLQVSAEIVYNLVADMLNQNIGVKGHKFIPLVFSLFIFVLFSNLLGMTPYSFTATSHIIVTFTLAIIVFLTVTIVGFVKHGLRFLTLFLPYGTPLWLAPLMIVIELFTYLAKPVSLSLRLAANMMAGHVLLKVIAGFTVSLMIYLKFLPIPIIVILIGFEIFVAILQAYIFTILSCMYLNDAINLH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ADAM2_RAT
Sequence: MWLLLLLLSGLSRLGGLSEPQTEGTREKLHVQVTVPEKIRSITSEGYETQVTYSLKIEGKTYILNLMQKAFLPPNFRVYSYDSTGIMRPLEQKFQNICYFQGYIEGYPNSMVIVSTCTGLRGVLQFGNVSYGIEPLESSSGFEHVIYQVEPKKGDTLLYAEKDMDLRDPQYKIRSIKPQRTVSHYLEIHIVVEKQMFEHIGADTAVVTQKIFQLIGLTNAIFAPFNLTVILSSLEFWMDENKISTTGDANKLLYRFLKWKQSYLVLRPHDMAFLLVYRDTTDYVGATYQGKMCDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGVAYDDVNTCQCGVPICVMNPEALHSSGVRSFSNCSMEDFSKFIVSQSSHCLQNQPHLQPSYKMAVCGNGELEEGEVCDCGQEGCDDKPPPCCNPTTCQLSEGSTCSTGSCCDASCNLKAKGELCRPANQECDVTEYCNGTSEVCEEDFFVQDGHPCAEQKWICINGTCQSGAQQCRDLFGTDADYGTKECYSELNSKSDISGSCGITPTGYKDCAPNDRMCGKLICIYQSEDILKMRSAIVIYANISGQICISLEYPPGHKESKKMCVRDGTVCGSGKVCLNQECVEDTFLNYDCTPEKCNHHGVCNNKKHCHCEPTYLPPDCKNTEDTWPGGSVDSGNQQRAESIPARSYVASAYRSKSARWPFFLIIPFYVVILVLIGMLVKVYSQRKKWRMDDFSSEEQFESESESKD
What is the function of this protein?
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.  Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct.  Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg.  This is a non catalytic metalloprotease-like protein (By similarity).
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 2, ADAM 2, Fertilin subunit beta, PH-30, PH30, PH30-beta.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PRPD_YEAST
Sequence: MFLAKNLKNNKIKVCLPKKKFAALSTASIQTNERPNPDKVLKDIAKYVHETPLKSSLALDTARLCFLDTLGCGLAALKFKQAQNIIKPIVPGTIVPSGTKILGTSYVMDPVKGAFAIGTLIRWLDYNDCWLAAEWGHPSDNLGGILAVADHLSRLNKATHGKNGKQFLVKDVLEAMIKAHEIQGIIALENSFNKVGLDHVVLVKVATAGVVSKMLGLSQEQTIEALSQAFVDGQSLRTYRHAPNTGSRKSWAAGDAVSRAVNLAYLVKNANVGTIPSVLTARTWGFYDVLFKGKPFSFQQRSKYDSYVMENVLFKISFPAEFHAQTAVEAAVKAYRILAKQGKTFKDIKSIRIRTQEAAMRIIDKSGPLYNYADRDHCIQYMIAVPLITGNLTATDYSDEVARNPEIDNLRSKMYCIEDTHLTQNYHDPDKRSIGNALLIELNDGTQLDEIFVEYPVGHKFRREEGIPLLMNKFQRHLREHFVESPDKVDLIMKVSSKTNFLNMQIDKYMDLFTEG
What is the function of this protein?
Catalyzes the stereospecific dehydration of (2S,3S)-2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate.
What are the official names of this protein?
Probable 2-methylcitrate dehydratase, 2-MC dehydratase, (2S,3S)-2-methylcitrate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the PrpD family.
Protein: Y274_BUCAI
Sequence: MSEKNKLPKGIIVLKTLSMPENINANGDIFGGWIMSQMDLGGAILAKEISGGKVATVRVDSINFLKSVSVGDIVNCYANCIKIGKSSIKINVEIWIKKIYSKPLGQYYCAAEAIFIYVAINKTGQPRELLPMSII
What are the official names of this protein?
Uncharacterized acyl-CoA thioester hydrolase BU274.
What is the protein family that this protein belongs to?
Belongs to the acyl coenzyme A hydrolase family.
Protein: MKNK2_XENLA
Sequence: MVQKKTTEMKGFHRSFKGQNPFDAAYEMEARNMESVFNFDCPSRPDVPSSAPIDIPDAKKRTKKKKRCRATDSFTGRFDDMYQLQQEILGEGAYAKVQSCINLITNKEYAVKIIEKRPGHSRSRVFREVEMLYQCQGHSNVLELIEFFEEEDKFYLVFEKMCGGSILNHIHRRRHFNEREASFVVRDIAEALNYLHNKGIAHRDLKPENILCESPHQVSPVKICDFDLGSGIKLNSDCSPISTPELLTPCGSAEYMAPEVVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPPFVGHCGSDCGWDRGEACPACQNMLFVSIQEGKYEFPEKDWAHISYGAKDLISKLLLRDAKKRLSAAQVLQHPWVQGNAPYNTLPTPIILQRNSSAKDLTSFAAEAIAMNRQLMEREEEEEGTENSSLCPFVVKATSCSMQLSPPSESKLAKRRQQGSKGGISPPSLAPLLIVSD
What is the function of this protein?
May play a role in the response to environmental stress and cytokines.  Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity).
What are the official names of this protein?
MAP kinase-interacting serine/threonine-protein kinase 2, MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, Mnk2.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Protein: GUC2C_CAVPO
Sequence: MKSPLLGLVVWSLLLQLLQPGLAFWNSQISQNCHNGSYEITVLMMNNYAFQESLESLKTAVNKGLDIVKQRLQEAALYVTVNATFIHSDGLIHKSGDCRSSTCEGLDLLREIARQKRMGCALMGPSCTYSTYQMYLDTELNYPMISAGSFGLSCDHKETLTRMMSPARKLMYFLVDFWKASNLPFKSFSWNTSYVFKNGTESEHCFWYINALEAGVSYFSQVLGFKEMLRGNEELQKILKDPNRRSNVIVMCGTPQTMESLKIDWTATEDTVIILVDLFNNYYLEENATAPDYMKNVLVLTLPPGNSTINTSLSKESLQEFSDFALAYLDGILLFGHMLKTFLRNGENTTAHKFAHAFRNLTFEGSTGPVTLDDSGDIDNTMVLLYTSVDTKKFKPLLFYDTRINQTTPIDTHPTFIWKNHRLPHDIPGLGPHILLIAVCTLAGVVVLILLIALLVLRKYKKDNELRQKKWSHIPPEKILPLETNEANHVSLKIDDDKKRDTVQRLRQCKYDPKRAILKDLKYSDGNFSEKQKIELDKLLPSDFYSLTKFYGTVKLDTRIFGVIEYCERGSLREVLNETISYPDGTIMGWEFKISVLYDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGYNSILPPKKDLWTAPEHLRQASTSQKGDVYSFGIIAQEIIMRRETFYTLSCRDQKEKIFRVEHPDGLKPFRPDLFLETAEEKELEVFLLVKNCWEEDPEKRPDFKKIENTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRPVVQSLKEKGIVEPELYEEVTVYFSDIVGFTTICKYSTPMEVVDMLNDLYKSFDQIVDHHDVHKVETIGDAYVVASGLPTRNGNRHAIDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKIPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILKRVQCQFLYEMRGETYLKGKGTETTYCLTGMKDQEYNLPTPPTVENQQRLQAEFSDMITNSLQKRQATGIKSRKPARVASYKKGTLEYLQLNTTDQDSTYF
What is the function of this protein?
Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP.
What are the official names of this protein?
Guanylyl cyclase C, GC-C, Heat-stable enterotoxin receptor, STA receptor, Intestinal guanylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single- pass type I membrane protein. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
Protein: RNZ_CHLTR
Sequence: MSYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIFISHFHGDHCLGLGSMLMRLNLDRVLHPIHCYYPASGKKYFDRLRYSTIYHETIKVIEHPIDREGIVEDFGNFRIESRQLDHLVDTLGWRITEPDTTKFIPEKIKAAGLKGPIMQELINKGQVKVNDTIVHLDDVSYTRKGDSIAVVADSLPCQAIVDLARNARILLCESTYLEEHSHLAKSHYHMTAKQAAEQAKRAEVQQLILTHFSARYNTTEEFVQEAGEIFPNVFAAEEFCSYEFPKNPS
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: RL10_CHLTB
Sequence: MKEEKKLLLREVEEKITASQGFILLRYLGFTATHSRSFRNNLSGVSAEFEVLKKKIFFKALETSGVEMDPEDSEGHLGVVFAYGDPVSAAKQVLDFNKQHNDSLVFLAGRIDNASLSGREVEAVAKLPSMKELRQQVVGLIAAPMSQVVGIMNSVLSGVVSCVDQKAEKTQE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: CH10_ORITI
Sequence: MKYQPLYDRVLVEPIHNDEAHGKILIPDTAKEKPTEGIVVMVGGGYRNDKGDITPLKVKKGDTIVYTKWAGTEIKLESKDYVVIKESDILLVKS
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PKNG_MYCBO
Sequence: MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF
What are the official names of this protein?
Serine/threonine-protein kinase PknG.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: GPH_PSE14
Sequence: MSGFEQLFAGKLPKLVMFDLDGTLVDSVPDLAVAVDTMLAELGRPIAGLESVRAWVGNGAPVLVRRALANHLDHSGVDDELAEQGLEIFMRAYAQKHEFTVVYPGVRETLKWLQKMGVEMALITNKPERFVAPLLDEMKLGRFFRWIIGGDTMPQKKPDPAALFFVMKMAGVPASQALFVGDSRSDVQAAKAAGVACVALSYGYNHGRPIAEENPAMVIDDLRKLIPGCLDMDAEILLPDINSPSSRESIVVVTRKLWMKVIKALARWRWRA
What is the function of this protein?
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.  Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
What are the official names of this protein?
Phosphoglycolate phosphatase, PGP, PGPase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
Protein: HRI1_CANGA
Sequence: MSAVLFKRLVFQVGDSANERTFTLSSVSKNGHFISLRPFTKPTEDEKKFPLEWVFAGTNDRVKVTPTTNADGKPVLQQDFDMGFDTNVYLNVENTHRGVINTFWQNWESGCVEETGKVFPFGNDKEGIPFMELWQPIDPNSKDLVILDAGDGRKIDGPVRSTVLKVVDGQDFEGLMIIVGEWAQGYLADKNKSSVDGLSFVRYHVSNEKLSSGLFEYGSQLSKFPTDFSNVKEGSLLTIDGLKWEVIEN
What are the official names of this protein?
Protein HRI1.
What is the protein family that this protein belongs to?
Belongs to the HRI1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SODE_SCHMA
Sequence: MTVYSYLVILFILLDNYCSAYGYGYSYYHRRHFDPAIASFTKEPYIGAVWFTQHGDYMYVNGSVAGLPPGKLLGTHVHRYGGLGNMCLEAGPHFNPFNQRHGPRHGYPRHAGDLGNIRVGRGGVAKFDFYVTIKGLGPFDGFIGRALVIHANRDDLGRNRDEGSRTTGNSGPRLACATIGFRAP
What is the function of this protein?
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
What are the official names of this protein?
Extracellular superoxide dismutase [Cu-Zn], EC-SOD.
What is the protein family that this protein belongs to?
Belongs to the Cu-Zn superoxide dismutase family.
What are the subcellular locations of this protein?
Secreted, extracellular space.
Protein: RL17_PASMU
Sequence: MRHRKSGRQLNRNSSHRQAMFRNMASSLVSHEIIKTTLPKAKELRRVVEPLITLAKVDSVANRRLAFARTRNIETVAKLFNELGPRFAQRAGGYTRILKCGFRTGDNAPMAYIELVDRPEVAAEEATAE
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: PDXH_MYXXD
Sequence: MHTCRAPFMLHRVMIPPDPIQRFAELFERAKQAIAVDPNAMVVATVGDDGRPSARVVLLKDFDARGFVFYTNHESRKGREARAHPYAALCFYWQPLNEQVRVEGRVERVTDAEADAYFQSRARGSQVGAWASLQSQPLATREELEARVAEVEQKYAGQPVPRPPHWSGFRVVPDRIEFWHAQESRLHDRHVYLREDGGWRTQMLYP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: CEP70_MOUSE
Sequence: MTEGSQIFLLPISTSDSTKEPLSPVASKAQDPSLLSNRLMIEKQQEEAEWESINGLLMTHGFKPLCLVKGADLRDFIVFDKQSSQKMRQILKTLMEETTRQQSMIRELIETNQQLKSELQLEQNRAAHQEQRANDLQQIMDSVKSKIGELEDESLNRVCQQQNRIKDLQKEYKMLQMKCQQYKKNRMEQEGTIASLQKEIHRLAKEEEERILTQNRVFAHLCRRVPHSVLDKQLLCLIDYYECKLRKLHIQRQFEEDSQSEEKDFTNLGASPNYKGVLMSLQKQLKESKSRIDVLVGEKLSLQKDLENRPTEHELRLYKQQVKKLEKTLKKNIKLQDLIGQKKSDDTEKKDEPSKDSHQQALIEQSYFQVLCSINSIVHNPRAPVIIYKQSKGRAPNGNKDIGQDCGFEHLVPIIEMWVDELTSLKDLYKSLKILSAELVPWHSLKKLDEKEGVKVGDLLFMVDTMLEEVENQKETSSTPNSQTLQAIVSHFQKLFDVQSLNGVFPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVVVSTVGKLCEIINKDVSEQVKQVLGPEDLQSIIKKLEEHEEFFPAFQAFANDLLEILEIDDLDAIVPAVKKLKILSY
What is the function of this protein?
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells.  During mitosis, required for the organization and orientation of the mitotic spindle (By similarity).
What are the official names of this protein?
Centrosomal protein of 70 kDa, Cep70.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: ISPG_BACFN
Sequence: MDLFNYSRRETSEVNIGAVPLGGPNPIRIQSMTNTPTQDTEACVAQAKRIVDAGGEYVRLTTQGVKEAENLMNINIGLRSTGYMVPLVADVHFNPKVADVAAQYAEKVRINPGNYVDPGRTFKQLEYTDEEYAAELQKIRDRFVPFLNICKENHTAVRIGVNHGSLSDRIMSRYGDTPEGMVESCMEFLRICVDEKFTDVVISIKASNTVVMVKTVRLLVSVMEQEGMSFPLHLGVTEAGDGEDGRIKSALGIGALLADGLGDTIRVSLSEEPEAEIPVARKLVDYITSRRNHPYIPGMEAPDFNYLSPVRRKTRPVRNIGGDHLPVVLADRMDGRMETHPQFTPDYIYAGRALPEQTEPGVQYILDADVWKGEPDTWPAFNYAQLELMETCAAELKFLFTPYMALTREVVACLKQHPEAVVVSQSNHPNRVGEHRALAHQLTVEGLQNPVIFFQHYAEDTAEDLQIKAGADMGALIFDGLCDGIYLFNQGKLSHAVIDATAFGILQAGRIRTSKTEYISCPGCGRTLFNLQSTIARVKEATSHLKGLKIGIMGCIVNGPGEMADADYGYVGAGRGKISLYKQKECIEKNIPEEEAVEKLIELIKANGDYEEKTSSLSSPKEKEDK
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: SYH_CHLPN
Sequence: MTVTLPKGVFDIFPYLADAKQLWRHTSLWHSVEKAIHTVCMLYGFCEIRTPIFEKSEVFLHVGEESDVVKKEVYSFLDRKGRSMTLRPEGTAAVVRSFLEHGASHRSDNKFYYILPMFRYERQQAGRYRQHHQFGVEAIGVRHPLRDAEVLALLWDFYSRVGLQHMQIQLNFLGGSETRFRYDKVLRAYLKESMGELSALSQQRFSTNVLRILDSKEPEDQEIIRQAPPILDYVSDEDLKYFNEILDALRVLEIPYAINPRLVRGLDYYSDLVFEATTTFQEVSYALGGGGRYDGLISAFGGASLPACGFGVGLERAIQTLLAQKRIEPQFPHKLRLIPMEPDADQFCLEWSQHLRRLGIPTEVDWSHKKVKGALKAASTEQVSFVCLIGERELISQQLVIKNMSLRKEFFGTKEEVEQRLLYEIQNTPL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFI4E_TOBAC
Sequence: MATEAPIEATEVPPASATETVAKQPHKLERRWTFWFDNQSKPKQGAAWGSSLRKAYTFETVEEFWSLYDQIFKPSKLTANADFHLFKAGIEPKWEDPECASGGKWTVTSSRKANLETMWLETLMALVGEQFDESEEICGVVASVRRSQDKLSLWTKTASNEAIQMSIGRKWKEIIDAEKISYSFHDDSKRERSAKSRYTV
What is the function of this protein?
(Microbial infection) Susceptibility host factor required for viral infection (e. g.  potato virus Y (PVY) and pepper mottle virus (PepMoV)) by recruiting viral RNAs to the host ribosomal complex via an interaction with viral genome-linked protein (VPg).
What are the official names of this protein?
Eukaryotic translation initiation factor isoform 4E, eIF(iso)-4E, eIF(iso)4E, eIF-(iso)4F 25 kDa subunit, eIF-(iso)4F p28 subunit, mRNA cap-binding protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4E family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RUXX_THEON
Sequence: MAERPLDVIHRSLDKDVLVILKKGFEFRGKLIGYDIHLNIVLAGAEMIQDGEVVKKYGKIVIRGDNVLAISPVDVGVE
What are the official names of this protein?
Putative snRNP Sm-like protein.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
Protein: TRMD_SHIB3
Sequence: MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CTAA_CAUSK
Sequence: MTSFLRSDRSRPVALWLFVVAVLVFAMVVVGGATRLTDSGLSITQWKPIMGALPPMSDEAWRANFELYKKIPQYRLVNAGMTLEAYKGIFWWEWAHRLLGRLVGVVFAIPFVFFLIRRMIPRRLIWRCAVLLGLGGLQGVVGWWMVSSGLSERVSVAPERLMTHLGLALALFVFVIWTALDAWAGSPRVEERTNWRGWALAFLGAVFFQSLLGALVAGNDAGLVYNDWPLMNGALVPAEYAGHGFWGTLAHSQGAVQLHHRLMAYALFVAAIVAGVAAARSRRLPEEAKLTAFVLVGVVCLQAGLGIWTLMTAVPLALGVLHQAGAAILLATATTFAWRVRRP
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NAGB_CLOB1
Sequence: MRIIVVDNYEEMSKKAAAMVASQVILKPDSVLGLATGDTPIGMYKEIINIYKNQKMDFSKARTFNLDEYYGLNRENPQSYYYYMMNNLFNHVNIDKNNINIPNGMADNIEIECKEYERKIDKAGGIDLQILGIGVNGHIGFNEPNISFESETHLVNLNEKTIESNSRFFSSKEEVPTKAISVGIKSIIHSKKIILLACGSAKSDAVSKTINGKINPNIPASILQLHRDVVVIIDKEAASKLNLK
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.