PharMolix/UniProtQA huggingface dataset:
Protein: PURT_SALNS
Sequence: MTLLGTALRPAATRVMLLGAGELGKEVAIECQRLGIEVIAVDRYPDAPAMHVAHRSHVINMLDGEALRHVITEEKPHYIVPEIEAIATDTLRELEGEGLNVVPCARATQLTMNREGIRRLAAEELGLPTSTYRFADSEASFHDAVAAVGFPCIVKPVMSSSGKGQSFIRSAEQLAQAWEYAQQGGRAGAGRVIVEGVVKFDFEITLLTVSAVDGVHFCAPVGHRQQDGDYRESWQPQQMSELALKRAQEIARHVVLALGGHGLFGVELFVCGDEVIFSEVSPRPHDTGMVTLISQDLSEFALHVRAFLGMPVGAIRQYGPAASAVILPQLTSQNVTFDNVHAAVGAGVQVRLFGKPEIDGSRRLGVALATGENVEEAVIRAKKAASRVTVKG
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: UL91_HCMVA
Sequence: MNSLLAELNRLGVAHATTEDVFIFVDRLFQHFSFLFQAEESGPRRLELVASVFEHLTVECVNDILDACSHPDVNVAETSNTCRPCPSPVPSAPKTVSGAQTSCATPRAPVT
What are the official names of this protein?
Protein UL91.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae UL91 family.
Protein: Y1104_AQUAE
Sequence: METTIFQFQKTFFTKPPKERVFVLHGEEQYLIRTFLSKLKEKYGENYTVLWGDEISEEEFYTALSETSIFGGSKEKAVVIYNFGDFLKKLGRKKKEKERLIKVLRNVKSNYVFIVYDAKLQKQELSSEPLKSVASFGGIVVANRLSKERIKQLVLKKFKEKGINVENDALEYLLQLTGYNLMELKLEVEKLIDYASEKKILTLDEVKRVAFSVSENVNVFEFVDLLLLKDYEKALKVLDSLISFGIHPLQIMKILSSYALKLYTLKRLEEKGEDLNKAMESVGIKNNFLKMKFKSYLKANSKEDLKNLILSLQRIDAFSKLYFQDTVQLLRDFLTSRLEREVVKNTSHGG
What are the official names of this protein?
Uncharacterized protein aq_1104.
What is the protein family that this protein belongs to?
To R.prowazekii RP189.
Protein: PS6AB_ARATH
Sequence: MATAMAEDTSFEGDQLASMTTDDIGRASRLLANEIRILKEESQRTNLDLESVKEKIKENQEKIKLNKQLPYLVGNIVEILEMSPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDTLKPGDLVGVNKDSYLILDTLPSEYDSRVKAMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKEQFEKLGIRPPKGVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDAFLLAKEKSPCIIFIDEIDAIGTKRFDSEVSGDREVQRTMLELLNQLDGFSSDDRIKVIAATNRADILDPALMRSGRLDRKIEFPHPTEEARGRILQIHSRKMNVNADVNFEELARSTDDFNGAQLKAVCVEAGMLALRRDATEVNHEDFNEGIIQVQAKKKASLNYYA
What is the function of this protein?
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins.  The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
What are the official names of this protein?
26S proteasome regulatory subunit 6A homolog B, 26S proteasome AAA-ATPase subunit RPT5b, Proteasome 26S subunit 6A homolog B, Regulatory particle triple-A ATPase subunit 5b, Tat-binding protein 1 homolog B, TBP-1 homolog B.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RS19_HAEDU
Sequence: MPRSLKKGPFLDLHLLKKVEKAVESGDKKPIKTWSRRSMIIPSMIGLTIAVHNGRQHVPVYVSDEMIGHKLGEFAPTRTYRGHAADKKAKK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: TDA11_YEAS8
Sequence: MNKFDEFIESNEKDLDVDTSTRNSIISMSPVRKTGRKIRSASSNGYRLEHHRTSSAGSMHSQRLMTPTRLNDQDHPLQAKPDARRVVTRHSSVSVPNAMSKRRSLIQPMVVPTTPESQNNLPSVSHSEGSYGIPLESTTVLSSEQAMASGLRRSRNGSSQSVNSMIATTIPTNGVDVSALLQSLATKELELLECKQKIEDLKKQTQHEEQNYTRRARELHELKEQVSKHLDPSLNTPVKNRAFSPVYQNIPLESRTENAGNSSLPSSVSKPKNMGHQSTNQSRSVSPQDIQERRQRDDSSDSSKQSLWSKPLALFNQFDKIIQHEIERTLNWDDSLSGTPEVQEGTPTSNSESSAQQYDNEAPGARQKSPSQGSVSRSLWSFVSDVKAGLLGIEEENDNDVITDNRCDPVYKSDRQHEQKKSTHKITNRGQAEDSGDDSSLNTRKFKTTTKFQKDNAGNNSLTDESGHRTREKKSKRSSNKLSFIGEPDNDNSSVKNSVEMTDF
What are the official names of this protein?
Topoisomerase I damage affected protein 11.
What is the protein family that this protein belongs to?
Belongs to the TDA11 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR4_SISSP
Sequence: RFKKIRRLGALPGLTNKRPRSGSDLKNQLRSGKRSQYRIRLEEKQKLRFHYGLTERQLLKYVHIAGKAKGSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSYRCKPRDIITTKDKQRSKALIQNSIASSPHEELPNHLTIDLFQYKGLVNQIIDSKWIGLKINELLVVEYYSRQT
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ISPE_CLONN
Sequence: MFFRAYAKINISLDVVGKREDDYHLLEMIMQRIELYDILEVTKNKTGINIKCNKSYVPLDERNLVYKAAKLFLDTYNLKGGVDFNIIKNIPVSAGLAGGSSDAATTLLAMRELYNIDVSDDELCKLGLKIGADVPYCIKGGTALCEGIGEKVTNLKGFKGHILVLVKPKFGVSTKEVYKSLDINKIYRHPNTEGLIKAVENNDLRYVSENMRNVLENVTLKKHTIIKEIKEKMIRSGALGSMMSGSGPSVFGFFDDMLKAQRCYEYFKSKYNDVYITRTI
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: VSR3_ARATH
Sequence: MKQLLCYLPWLLLLTLLVSPLNDARFVVEKNSLSVTSPESIKGTHDSAIGNFGIPQYGGSMAGTVVYPKENQKSCKEFSDFSISFKSQPGALPTFLLVDRGDCFFALKVWNAQKAGASAVLVADNVDEPLITMDTPEEDVSSAKYIENITIPSALVTKGFGEKLKKAISGGDMVNLNLDWREAVPHPDDRVEYELWTNSNDECGVKCDMLMEFVKDFKGAAQILEKGGFTQFRPHYITWYCPHAFTLSRQCKSQCINKGRYCAPDPEQDFSSGYDGKDVVVENLRQLCVYKVANETGKPWVWWDYVTDFQIRCPMKEKKYNKECADSVIKSLGIDSKKLDKCMGDPDADLDNPVLKEEQDAQVGKGSRGDVTILPTLVVNNRQYRGKLEKSAVLKALCSGFEETTEPAICLSTDVESNECLDNNGGCWQDKSANITACKDTFRGRVCECPTVDGVQFKGDGYSHCEPSGPGRCTINNGGCWHEERDGHAFSACVDKDSVKCECPPGFKGDGTKKCEDINECKEKKACQCPECSCKNTWGSYECSCSGDLLYIRDHDTCISKTGAQVRSAWAAVWLIMLSLGLAAAGAYLVYKYRLRQYMDSEIRAIMAQYMPLDSQPEIPNHVNDERA
What is the function of this protein?
Vacuolar-sorting receptor (VSR) involved in clathrin-coated vesicles sorting from Golgi apparatus to vacuoles.
What are the official names of this protein?
Vacuolar-sorting receptor 3, AtVSR3, BP80-like protein a', AtBP80a', Epidermal growth factor receptor-like protein 2a, AtELP2a.
What is the protein family that this protein belongs to?
Belongs to the VSR (BP-80) family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass type I membrane protein. Prevacuolar compartment membrane; Single-pass type I membrane protein.
Protein: EX1_BUCBP
Sequence: MDIQKNTSLTFLFYDYETFGKNPALDKPSQFSCIQTDIDFNIIGSIQEIFCYPSVDYLPDPESVLITGISPKYTSLFGVNEFEFAKKIYSLFMKSDTCIIGYNNIYFDDEFTRNIFYRNFLNSYEWSWKNGNSRWDMLDLLRACYVLRPEGINWPRNEDNSVSLRLSDISLANNIVHNVAHNASSDVYATMNIAKLIKQKKPKLFNFFFKYRTKKAILTLIDVNSLNPIVYISRFFGVVNRYISYIVPILWHPINSNILVSIDLSQDVQKILNFFKRNSILNVNYKEIFLMGIRFIYVNRCPILIPTNVIRMKDRIRLRINYKLFQNNLVLLRKNIFLKKKLKKFLCSIAEAPKYNGSNVDLKMYNSFFSYIDNNVIKNIHSTLPKRIKINFMKYDNRINQLFILFLARYRPDMLDYSEKYFWIQRYLNIFSYANIQKYENKILKLIVKYKNHVRNVQLLEELFEYVKYTRKNFLKSIFTN
What is the function of this protein?
Degrades single-stranded DNA (ssDNA) in a highly processive manner.  Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase.
What are the official names of this protein?
Exodeoxyribonuclease I, ExoI, Exonuclease I, DNA deoxyribophosphodiesterase, dRPase.
Protein: PMIP_ASPCL
Sequence: MKPQLLTPLRRRPWTCRQCLQRLQRLQQQTRRSFETAASPAPGHTQVDYIPADASQSKKVDDETIRRVFDSQHFWREFSQRRSTQSKPTGLVQNQYLTSPDGFRTFANVSLQKCQAIVSKVLAASTLEEYRTMARDLDRLSDLLCRVIDLSDFIRVIHPDPRVQEAATQAYALMFEYMNVLNTTTGLNDQLKKAVANPEVASHWTEEEKIVAQILIKDFSNSAILMPPQERQRFVNLSNDISQLGSSFVNSPEPAKSQVVVNANSLRGLDPMLVQQIKRWNRTASVPTTGMIPRLALRSVHDESVRREVYLASRTSSARQLHRLEELLLKRAELAKLSGYSSFGHMTLSDKMAKSPEAVSNFLTSLVDSNRTLVREELLQLRNMKGSPLQPWDHAYYVHKRVMQYSQSRRSRELSAVPEFFSLGTVMQGLSRLFDRLYGVRLVPQEAAPGETWNPDVRRLDVVDEADRHIAVIYCDLFSRPNKHPNPAHFTLRCSREISATEVAECASLDQSSHPNDGMATAVDPTTKTLRQLPTIALVCDFAEPAAHGGRPSLLSEHSVRTLFHEMGHALHSILGQTRLQSISGTRCATDFAELPSVLMEHFATAPSVLSLYARHWETDEPLSERMIQSMERDRTAHGSIYGAVENEAQILMALVDQEYHSRPADGGRIDSTALYHEVAQRHSSLPDPAETAPPTSWQGFFGHLYGYGATYYSYIFDRAIANKLWADVFGAGRAAVDRAAGERYKTEVLRWGGGRNGWQCVAGVLGPSNASNADGRLVEGGDEAMREVGRWGLGRDGVSG
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP, Octapeptidyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: Y1742_SACEN
Sequence: MSANEQWDIVSGVGITALAVAVARARESRRDDRLIDDPYAEPLIRAAQPPVPMSGDGGEAGALWHEMTDYVSVRSRFFDEWFARACAAGTRQAVVLASGLDTRAFRLEWPEGFRVFEIDQPKVLEFKDGTLAAEGVRASCERHAVAVDLRDDWASALVKAGFDPALPTAWLAEGLLPYLPPEAEANLLATVHDLSARGSRIAIESIALARSALLGADLDDTAREWGIDLKGLFSLEDRPDPGDVLAQRGWRVHRDPVGDLAAGFRRPLSDRAQQLGAAGEMVTAQRD
What is the function of this protein?
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
What are the official names of this protein?
Putative S-adenosyl-L-methionine-dependent methyltransferase SACE_1742.
What is the protein family that this protein belongs to?
Belongs to the UPF0677 family.
Protein: HUTI_KLEP3
Sequence: MTQATSERVIWRNARLATLNPDYSQPYGLLERHALLVRNGRIEAIVADADAPGGRSIDLEGRLVTPGLIDCHTHLIFGGSRAQEWEQRLNGVSYQTISANGGGINSTVRATRDSSEAELLALAQPRLARLLREGVTTLEIKSGYGLDLQNERKMLRVARQLADDNGVELSATLLSAHATPPEYHGDADGYISLVCETILPTLWQEGLFESVDVFCENVGFSPQQTERVFQAAQALGIPVKGHVEQLSSLGGAQLVSRYHGLSADHIEYLTEEGVAAMRESGTVAALLPGAFYFLNETRKPPVELLRKYQVPMAVATDFNPGTSPFASLHLAMNMACVKFGLTPEEAWAGVTRHAARALGRQDSHGQLAAGFVANFAIWDAEHPVEMVYEPGRAPLWGRVVRGERQ
What is the function of this protein?
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate.  It is the third step in the universal histidine degradation pathway.
What are the official names of this protein?
Imidazolonepropionase, Imidazolone-5-propionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. HutI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2554_METFK
Sequence: MFELKTVALFVITALAEIIGCYLPYLWLNQNKSPLLLIPAAISLALFAWLLTLHPSAAGRVYAAYGGVYIFVAIFWLWVVDDIIPSNWDFLGASVALLGMAIIMFAPRST
What are the official names of this protein?
UPF0060 membrane protein Mfla_2554.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RR15_LEPVR
Sequence: MIKNAFISFQEQKEESRGSVEFQVFIFTNKIRRLTSHLELHRKDYLSQRGLRKILGKRQRLLAYLSKKNRVRYKELINQLNIRELKTR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS8_PARL1
Sequence: MTMTDPLGDMITRIRNAQLRGKGKVVTPASKLRGWVLDVLAEEGFIRGYARVEYPGGKSDFEIELKYNEGAPVIQMIERVSTPGRRVYSSVKTMPTVHNGLGISILSTPKGIMSDVAAREQNVGGEVLCRVF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: V143_NPVOP
Sequence: MNSILSRLFRDVTGDEEYAVNSLRDANRLIIIDTDTGTRRLLEHVSNFRRFLNTIRSDAAGACARHQRAARHDDEEEAPPAARVSFAGHSLVLENNDFCVFVKPFLLKRHYDEIKNYLKLDRFFKSDNPEHTNMCVQAGDYCYWPNWPASQAVSFTGWQLYLYVEFGIVVESTVPIIHNRRLGPVDLFVFNPRTFLNIEMNLSTNEAPPVKLFVNGKFDFEKKVAESGKAVESLFEIKMANGATATCKMIANLVNSNKNLFEVIRDNINLEECVTTPKYRHIIDVNLTKLRQFAHDGAVLAPPVERAFRAPTVTTILSASSENAEVIQSEIDAALVKVREGMVKVMAEFNRSDDPDLLQAYFKESGFKNFHFLLFNVWKQITKRDKKSFRETDMKLFFELVCETLFGNDSDALATALVKCEPFTTRGVATFNSLCDHWHCFKGVNPYTLLGSYYGAHYFIYLKLTSSDAHECDDPWAFNYKNAMECKVPPKALGEAFFIKVENVVTQVTLVFNGEHYQIVKKDDELYKLVETNPYKLQNIKFNNWKYMYHTKYGVYNVVTDDFYSNCPFLLGTTMPGTFKRPDDPPYLPEAVFAHMLATSAEERDILRTYHIAKLCRDVKMVKVNLGTVNLLGDCAPCKLDARLRLNDLFRELWNLDDDSLVTLALYVNKLRVEDIVHNFKCGACRASVQERKCRCVQKIKINRQALKTCLIFDLFVGDPELTQLMWMLIFATNKLYINTALIVTTSKLVAQHAHFFTKEHIKIAAILHRDLHKIEFVDTLMADVCNHDAFLAYLQHAVANEPAAAPAADNAVAKFYAHYANAANILHKYKNLWWDKIILARDSDTLSSWLTRFYLRVILSKMDVQNYPVAYLTQVVEGYLYFKRYTNFNHASSYMLMHFAASLSVPTDYGRKAVYLPGVPLSGKSTFFELLDFLVLMHKFDDDTHTGASKETSDKEVSNLNSEVYTINELKKCSESFFKKHADSSKSDSKSRKYQGLLKYEANYKMLIVNNNPLYVDDYDDGVQNRFLIVYTDHKFLPHVRFSGSVYHHILTKQYPQEPMVVDALKDSVRVFLAHVVRYQREPQTGLVPYKTLLDSDPVHQHNLTRLSVNNSPMYAVIYILNIKTAPRSANTFVTEEKMQEMIGYATLHLKSFLHPSFTQYNAAKNINAGTARSFVFDEKILLQQIKDKFKNNYDERGCKFNNLTMALNKLDININVPQFKC
What is the function of this protein?
Essential for the initiation of viral DNA replication, it may contribute to other functions such as controlling the switch to the late phase and leading to the inhibition of host protein synthesis.  Required for late and very late gene expression (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase P143.
What are the subcellular locations of this protein?
Host nucleus.
Protein: PLSX_PASMU
Sequence: MSRLTLALDVMGGDIGPRITIPASLIALEKDPMLSLLLFGDSQQILPLLENIPASMKERLTVCHCSRTIDNEHGISYALRHSKGTSMRLAIEAVQKGDAQGCVSAGNTAALMGLSKILLQPLKGIQRPALISVIPTVDGGKSVMLDLGANIDCDAENLYQFALMGSIFAENTLNLVYPRIALLNIGSEDIKGHKSIRDAAMLLEKDPALNYTGFIEGNFLLNGQADVIVSDGFVGNVALKTLEGAAKNVIALIKGKSKNSLLKPLFSWLLTHIFKESYQRLKRINPDEYNGASLIGLTAVVVKSHGSANSDAFAYAIADAAFQTRQQIPTKILAGLEKY
What is the function of this protein?
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP).  This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
What are the official names of this protein?
Phosphate acyltransferase, Acyl-ACP phosphotransacylase, Acyl-[acyl-carrier-protein]--phosphate acyltransferase, Phosphate-acyl-ACP acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the PlsX family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Associated with the membrane possibly through PlsY.
Protein: TRMB_STRP1
Sequence: MRVRKRKGAEEHLANNPHYVILNPEDAKGRWHDVFGNDRPIHIEVGSGKGGFITGMALKNPDINYIGIDIQLSVLSYALDKVLASEVPNVKLLRVDGSSLTNYFEDGEVDMMYLNFSDPWPKTKHEKRRLTYKDFLDTYKRILPEHGEIHFKTDNRGLFEYSLASFSQYGMTLRQIWLDLHASNYEGNVMTEYEEKFSNKGQVIYRVEANF
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: MINC_CLOAB
Sequence: MFRDGITIKGNKEGLNVIININSFKDFDEMLDAFIAKLSKGKRFYKGCTLRITTQLKEINERNTRKLKDILFDEFLIKDCIFEDSDENKSKVFSGIYEGRTKFLRRTVRSGQIIKYSGNVVIVGDVNPGSEIYAGGNVIVFGILRGDVHAGSTGNDKAIIAALRLQPKILQIANRISRAPEDDDKPDYPEVARLKGDAIIVEPYSPNKFNI
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: PURT_PSYIN
Sequence: MSVSIFGSAKANSATKALLLGSGELGKEVAIELQRFGIEVIAADSYENAPAMQVAHSSHVVSMLDGEKLATIIRAEKPDFIIPEVEAIATDTLLALEAEGFNVVPTARAAKLTMDREGIRRLAAETLGIKTSPYIFADSKEEYLSAIEKIGKPCVIKPVMSSSGKGQSIVKSAADLDNAWTYSQVGGRSGEGRIIIEGFVPFDYEITLLTVNAVDGTHFCDPIGHRQENGDYRESWQPQAMSTVALQKAQNIAKKIVTELGGYGLFGMEFFVKGDQVYFSEVSPRPHDTGLVTLVSQDASEFALHVRAILGFPIGRIIQYGPCASSVILGNGLSDDIKFTNLDQALGSVAGAQIRLFAKPDINGQRRLGVAIARGETVEEAVDNAKTVSNKVNIIY
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: PYRR_BREBN
Sequence: MINKSVIMDEAAIRRALTRIAHEIIERNKGVEDLIIVGIKTRGIYLAQRLVERIEMIENVKVPVGELDITFYRDDLQHKSEDAILQGSKLPDQITGKTVILVDDVLYTGRTVRAALDALIDNGRPRMIQLAVLVDRGHRELPIRPDFVGKNLPTARTEIVDVQLAEVDVMDIVSIRQLL
What is the function of this protein?
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
What are the official names of this protein?
Bifunctional protein PyrR.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
Protein: URDA_STRMU
Sequence: MKLIAIVGTNAKQSYNRILLQFMKRHFVQKADIDIMEIANVPMFNETEDQTDLPAIQNFNTKISQADGVIIATPEHNHTIPSSLNSLLEWLSFKVHPLDGKPLMIVGASYDVQGSSRAQLHLRQILDAPGVNAAVMPGSEFLLGRAHQAFDEAGNLKSEATVDFLESCFFKFLRFVQVANQLNEPEEVSFEAGTYQVTTQGHNGKLPMTVTLSEEKIEKIDIDSSGESSGIADIVFTRIPNEILEGQTLNVDAVSGASVTSNGVLDGVARAIKLAGGNPDVLRKRPKAPSALDKEDKTYSTDVVIVGGGGAGLAAAARVLQAGKQVMVLEKFPALGGNTVRSGGLLNAADPEWQKTFPANPGEAHNLSELIQTDEDSIAAEYLADFKELKQQVTNYLKDPSYLFDSNILHRIQTYIGGKRTDRNGCEVYGNYDLVKVLTDKDLDSVHWLADIGVDFDRSEVSMPVGALWRRSHKPKQPMGYAFIEALDTYIRKNSGTILTDTAVTDFILENGLIKGVLAKGRNGQTITVHAQAVVLASGGFGANTKMLQQYNTYWSNIDDNIQTTNSPAITGDGIRLGQSIGAALVGMGFSQMMPVSDPNTGAIFSGLQVPPANFVMVNQEGKRFVDEYGSRDTLSKAAIDNGGLFYLIADENIKATAMNTSNEKIEEQVAAGTLYRADTLESLAEQIGVDPATLVETINNYNSYVEAGYDPEFDKGAFDLKVEKAPFYATPRKPATHHTMGGLKIDTQAHVIKEDGNKIPSLYAAGEVTGGIHAGNRLGGNALADIFTFGRIAAETAVTECC
What is the function of this protein?
Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino-histidine).  Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1.  Therefore, the UrdA enzyme from the gut bacteria S. mutans strain UA159 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite dihydrourocanate.
What are the official names of this protein?
Urocanate reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
Protein: RAEL1_PIG
Sequence: MSLFGTTSGFGTSGTSMFGSTTTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLNSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK
What is the function of this protein?
Plays a role in mitotic bipolar spindle formation.  Binds mRNA.  May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.
What are the official names of this protein?
mRNA export factor, Rae1 protein homolog, mRNA-associated protein mrnp 41.
What is the protein family that this protein belongs to?
Belongs to the WD repeat rae1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited from interphase nuclei to spindle MTs during mitosis.
Protein: NIKR_SALAR
Sequence: MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRGALAQEATQEHGTYGFAVLSYVYEHEKRDLASRIVSTQHHHHELSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRGVRHGHLQCLPKED
What is the function of this protein?
Transcriptional repressor of the nikABCDE operon.  Is active in the presence of excessive concentrations of intracellular nickel.
What are the official names of this protein?
Nickel-responsive regulator.
What is the protein family that this protein belongs to?
Belongs to the transcriptional regulatory CopG/NikR family.
Protein: Y3206_RHILO
Sequence: MSAYWIAVASAQHVRRGRNDGFMQVNHGKAAPLRRVKPGDGIVYYSPTTILGEKDGLQAFTAIGTVRYGKESPYQGEMGGGFTPFRRDVEWAVAEEAPIKPLLDRLDFTAGKSNWGYHLRFGLFEITDHDFRLIAEAMGAPKTLAEATA
What are the official names of this protein?
UPF0310 protein msl3206.
What is the protein family that this protein belongs to?
Belongs to the UPF0310 family.
Protein: VP1_POVBA
Sequence: MAPTKRKGECPGAAPKKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDDNLRGYSQHLSAENAFESDSPDRKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVKTEVIGITSMLNLHAGSQKVHENGGGKPVQGSNFHFFAVGGDPLEMQGVLMNYRTKYPQGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWIPDPSRNENTRYFGTYTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQKVDGQPMYGMESQVEEVRVFDGTEQLPGDPDMIRYIDRQGQLQTKMV
What is the function of this protein?
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter.  The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins.  Interacts with gangliosides GT1b and GD1b containing terminal alpha(2-8)-linked sialic acids on the cell surface to provide virion attachment to target cell.  This attachment induces virion internalization predominantly through caveolin-mediated endocytosis and traffics to the endoplasmic reticulum.  Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating.  Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus.  Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal.  In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.
What are the official names of this protein?
Major capsid protein VP1, Major structural protein VP1.
What is the protein family that this protein belongs to?
Belongs to the polyomaviruses coat protein VP1 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: DNMK_BPR69
Sequence: MELIFLSGIKRSGKDTTADYINSNFKSIKYQLAYPIKDALAIAWERKHAENPDVFTELKYEYFEGIGYDRETPLNLNKLDVIELMEETLIYLQRQYLPINGVNILSSLEGGYSYLDIKPYEALREAINNINDTWSIRRLMQALGTDVVVNLFDRMYWVKLFALNYMDYIGSDFDYYVVTDTRQVHEMETARAMGATVIHVVRSGTESTDKHITEAGLPIEEGDLVITNDGSLEELYSKIEKILR
What is the function of this protein?
Acts on dGMP, dTMP and 5-hydroxymethyl-dCMP while excluding dCMP and dAMP.
What are the official names of this protein?
Deoxynucleotide monophosphate kinase, DNK, dNMP kinase, Gp1.
What is the protein family that this protein belongs to?
Belongs to the dNMP kinase family.