PharMolix/UniProtQA huggingface dataset:
Protein: BOA10_BOTFB
Sequence: MENPVLIQKAPRRYKSAIPLFLFHDGGGTVLPYYFLESLNRNVWGVSYPHLNDGGTFEHGIKGMGELYAGYIRGKVSRGKVLLGGWSAGGSIAIQVAKCLENIPELCVAGIILLDTPFPDFPDWRPKNSPPVQFHIPVVPDQTAKSRLAQQQAVNDIIHALSVWELPTWENGRRPPPAVFIRALKVVPTEKVVEVDWFREEYALGWQKYPYNFIVEELRVDGDHFSIFTPSYLPELSTKLREALDLLDSKPETGILLDSKLNSSIVISAL
What is the function of this protein?
Probable thioesterase; part of the gene cluster B that mediates the biosynthesis of botcinic acid and its botcinin derivatives, acetate-derived polyketides that contribute to virulence when combined with the sesquiterpene botrydial (PubMed:21722295).  Botcinic acid and its derivatives have been shown to induce chlorosis and necrosis during host plant infection, but also have antifungal activities (PubMed:21722295).  Two polyketide synthases, BOA6 and BOA9, are involved in the biosynthesis of botcinins.  BOA6 mediates the formation of the per-methylated tetraketide core by condensation of four units of malonyl-CoA with one unit of acetyl-CoA, which would be methylated in activated methylene groups to yield a bicyclic acid intermediate that could then either be converted to botrylactone derivatives or lose the starter acetate unit through a retro-Claisen type C-C bond cleavage to yield botcinin derivatives (PubMed:23203902).  The second polyketide synthase, BOA9, is probably required for the biosynthesis of the tetraketide side chain of botcinins (Probable).  The methyltransferase (MT) domain within BOA6 is probably responsible for the incorporation of four methyl groups (Probable).  The trans-enoyl reductase BOA5 might take over the enoyl reductase function of BOA6 that misses an ER domain (Probable).  The monooxygenases BOA2, BOA3 and BOA4 might be involved in further hydroxylations at C4, C5 and C8, whereas BOA7, close to BOA9, could potentially be involved in the hydroxylation at C4 in the side chain of botcinins (Probable).
What are the official names of this protein?
Probable thioesterase BOA10, Botcinic acid biosynthesis cluster B protein 10.
What is the protein family that this protein belongs to?
Belongs to the AMT4 thioesterase family.
Protein: WDR5_HUMAN
Sequence: MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
What is the function of this protein?
Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960).  May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960).  As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245).  H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606).  As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852).  May regulate osteoblasts differentiation (By similarity).  In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).
What are the official names of this protein?
WD repeat-containing protein 5, BMP2-induced 3-kb gene protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat WDR5/wds family.
Protein: MCM6M_XENTR
Sequence: MELGGPATAGATDTAGQLFKDELSDKCQKLFLEFLEECKGKDGSNLYVSAAEELVRPERNTLVVNFTDIEYYNQQLATTIQEEYYRVYPHLCRAVRSFARQMGNIPANKEFYVAFSDFPARQKIRELSSAKIGTLLRISGQVVRTHPVHPELVSGTFLCMDCQSVVKDVEQQFRYTQPTICKNPVCANRRRFTLDTNKSRFVDFQKVRIQETQAELPRGAIPRSVEIILRAEAVETAMAGDRCDFTGTLIVVPDISALAAGDARMETGAKVTGGEGFNSEGVQGLKALGVRDLSYRLAFLACHVGATNPRFGGKDLREEDQTAESIKNQMTVQEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEIKRGVLLMLFGGVPKTTMEGTSLRGDINVCIVGDPSTSKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPVGGRYERSKSLKHNVNLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHARNEESIERVYSIEDIQRYLLFARQFQPKITKEAEEFIVEQYRRLRQRDGSGVAKSSWRITVRQLESLIRLSESMARMHCSDEVQPKHVKEAFRLLSKSIIRVDTPDVSFDQGEDEKNVEEEVNNANLNNGEEAMETNQDEPINDKPSTNAGLKMSFAEYKQISNLLVLHMQKMEEVEEECHLTTTDLVNWYLKEMEAEIETETELILKKRLIEKVIHRLINYDHILIELNKSELKTMDDSKETSEDAAEDRILVVNPNYMLED
What is the function of this protein?
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.  The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.  The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.  The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development.
What are the official names of this protein?
Maternal DNA replication licensing factor mcm6, Maternal minichromosome maintenance protein 6, mMCM6.
What is the protein family that this protein belongs to?
Belongs to the MCM family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.
Protein: RS17_PHEZH
Sequence: MPKRILEGVVVSDKGDKTVVVKVERTFLHPVLKKTVRRSKKYHAHDEANTYKVGEVARIIECAPKSKLKTWEVLPKGGAAQA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: AFTB_MYCTU
Sequence: MVRVSLWLSVTAVAVLFGWGSWQRRWIADDGLIVLRTVRNLLAGNGPVFNQGERVEANTSTAWTYLLYVGGWVGGPMRLEYVALALAMVLSLLGMVLLMLGTGRLYAPSLRGRRAIMLPAGALVYIAVPPARDFATSGLESGLVLAYLGLLWWMMVCWSQPLRARPDSQMFLGALAFVAGCSVLVRPEFALIGGLALIMMLIAARTWRRRVLIVLAGGFLPVAYQIFRMGYYGLLVPSTALAKDAAGDKWSQGMIYVSNFNRPYALWVPLVLSVPLGLLLMTARRRPSFLRPVLAPDYGRVARAVQSPPAVVAFIVGSGVLQALYWIRQGGDFMHGRVLLAPLFCLLAPVGVIPILLPDGKDFSRETGRWLVGALSGLWLGIAGWSLWAANSPGMGDDATRVTYSGIVDERRFYAQATGHAHPLTAADYLDYPRMAAVLTALNNTPEGALLLPSGNYNQWDLVPMIRPSSGTAPGGKPAPKPQHAVFFTNMGMLGMNVGLDVRVIDQIGLVNPLAAHTERLKHARIGHDKNLFPDWVIADGPWVKWYPGIPGYIDQQWVTQAEAALQCPATRAVLNSVRAPITLHRFLSNVLHSYEFTRYRIDRVPRYELVRCGLDVPDGPGPPPRE
What is the function of this protein?
Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall.  Catalyzes the transfer of arabinofuranosyl (Araf) residues from the sugar donor decaprenyl-phospho-arabinose (DPA) to the arabinan domain to form terminal beta-(1->2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids.
What are the official names of this protein?
Terminal beta-(1->2)-arabinofuranosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AftB family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TX72E_SCOMU
Sequence: MLVFYALLFVSVFSNTVMGATIDMPIPKPILREAIEEIDVNKRADSHYCKEENCPPGKHCPKVPIVCRRGPCCF
What is the function of this protein?
Inhibits voltage-gated potassium channels.
What are the official names of this protein?
Kappa-scoloptoxin(07)-Ssm2e, Kappa-SLPTX(07)-Ssm2e, Kappa-scoloptoxin-Ssm2e, Kappa-SLPTX-Ssm2e.
What is the protein family that this protein belongs to?
Belongs to the scoloptoxin-07 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TNNC2_PIG
Sequence: TDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNMDGYIDAEELAEIFRASGEHVTDEEIESIMKDGDKNNDGRIDFDEFLKMMEGVQ
What is the function of this protein?
Troponin is the central regulatory protein of striated muscle contraction.  Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.  The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
What are the official names of this protein?
Troponin C, skeletal muscle.
What is the protein family that this protein belongs to?
Belongs to the troponin C family.
Protein: KPR3_YEAST
Sequence: MPTNSIKLLAPDVHRGLAELVAKRLGLQLTSSKLKRDPTGEVSFSIGESVRDQDIFIITQIGSGVVNDRVLELLIMINASKTASARRITAIIPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKENVNYMDSIIISPDAGGAKRAATLADRLDLNFALIHKERARANEVSRMVLVGDVTDKICIIVDDMADTCGTLAKAAEILLENRAKSVIAIVTHGVLSGRAIENINNSKLDRVVCTNTVPFEEKIKKCPKLAVIDISSVLAESIRRLHNGESISYLFKNYPL
What is the function of this protein?
5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis.  Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase 3, Phosphoribosyl pyrophosphate synthase 3.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DOCK5_MOUSE
Sequence: MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYALQNRSKKGIFPETYIHLKEATVEDGGQHETVIPGELPLVQELTNTLREWAVIWRKLYVNNKVTLFRQLQQMTYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETSTVALFRAHEVASKRIEEKIQEEKSILQNLDLRGQAIFSTVHTYGLYVNFKNFVCNIGEDAELFIALYDPDQSTFISENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSTDLIRPRISLVCQIVRVGRMELKEGKKHTCGLRRPFGVAVMDISDIVHGKVDDEEKQHFIPFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVFDEEGNLLEKAIHPGAGYEGVSEYKSVVYYQVKQPCWYETVKVFIAIEEVTRCHIRFTFRHRSSQESRDKSERAFGVAFVKLMNADGTTLQDGRHDLVVYKGDNKKMEDAKYYLTLPGTKAELEEKELQASKNPSVFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMMEMSDNETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAHVKLSKVLNFYVANAEDPSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSEDGDEFNDSIRQLFLAFNTLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPMELSVLFCKFIQSIPDNQLVRQKLNCMTKIVESSLFQQAECREVLLPLLTDQLSGQLDDHSTKPDHEASSQLLSNILEVLDRTDVGPTSAHVQLIMERLLRRINRTVIGMSRQSPHIGSFVACMIAVLRQMEDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRAINQFAEVLTKSFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSEAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNLSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLANSGEAFAFLVSSLLENLLDYRTIIIHDESKENRMSCTVNVLNFYKDKKREDIYIRYLYKLRDLHRDCENYTEAAYTLLLHAELLQWSDKPCVPHLLQRDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGSLLKKRALFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYLQCFTVKPVMSLPPSYKDKPVPEQILNYYRANEVQQFSYSRPFRKGEKDPENEFATMWIERTTYRTAYTFPGILKWFEAKEISVEEISPLENAIETMELTNERVSNCVQQHAWDHSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQIPLLTEGIRIHGEKLTEQLKPLHARLSSCFRELKEKVEKLYGVITLPPSMTERKPSRAGSMVLPYILSSTLRRLSVTSVASSVISTSSNSSDNASSRPGSDGSILEPLFERRASSGARVEDLPPKEDSENRISKFKRKDWNLSKSQVIAEKAPEPDVMSPGKKTQRPKSLQLVDSRLTPFHSPSPLQSTALSPPPLTPKATRTLSSPSLQTDGLTASVPPPPPPKSKPYESSQRNSAEIAPPLPVRRDSKAPPPPPPKARKSGILSSEPGSQ
What is the function of this protein?
Guanine nucleotide exchange factor (GEF) for Rho and Rac.  GEF proteins activate small GTPases by exchanging bound GDP for free GTP (PubMed:18396277).  Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (By similarity).
What are the official names of this protein?
Dedicator of cytokinesis protein 5, Lens rupture protein 2, Rupture of lens cataract protein.
What is the protein family that this protein belongs to?
Belongs to the DOCK family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=Associated with the edge of the plasma membrane in intestinal epithelial cells spreading on type IV collagen.
Protein: KISH_DICDI
Sequence: MVAIFNFQSLLVVILLFICTCTYIRGSYPSLLEVRDKHSFSGLPRKAAIIGERLSPWVSACCLIMGLWTLYN
What is the function of this protein?
Involved in the early part of the secretory pathway.
What are the official names of this protein?
Protein kish, Transmembrane protein 167.
What is the protein family that this protein belongs to?
Belongs to the KISH family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type I membrane protein.
Protein: CTFA_CONCB
Sequence: CRVENKCPHTVCCDRSRCSCKLIRTRPLMYHVCVC
What are the official names of this protein?
Conotoxin Ca15a.
What are the subcellular locations of this protein?
Secreted.
Protein: B4GT3_MOUSE
Sequence: MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDPGPTFDYSHPHDVYSNLSHLPAAPGAAGAPPAQALPYCPERSPFLVGPVSVSFSPVPSLAEIVERNPRVESGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYRLLARELGPLYTNITADIGTDPRGPRSPSGPRYPPGSSQAFRQEMLQRRPPARPGPLPTANHTAPRGSH
What is the function of this protein?
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
What are the official names of this protein?
Beta-1,4-galactosyltransferase 3, Beta-1,4-GalTase 3, Beta4Gal-T3, b4Gal-T3, Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase, Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, N-acetyllactosamine synthase, Nal synthase, Neolactotriaosylceramide beta-1,4-galactosyltransferase, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 7 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
Protein: AQDC1_RHOER
Sequence: MNMPQLSTIQIGDHELAYLDNKLTSAVTPTIVMLPGWCGDHHSFSELIPQLNDTHRVVAVNWRGHAPVPHDVSDFGYAEQAQDALAILDAIGVDEFLPVSASHGGWALVQLLVDAGPARARAGVVLDWLMRRPTPEFTAALLSLQDPEGWVDSCRALFHTWRPNDSDWVESRVERAKEFGFDMWARSGRVISGAYGEHGTPLEFMKTITPERHIRHLFSTPSDSDYVAPQEAFASENEWFSYALLGGTSHFPHLEMPDRVAAHIVELAKNTYQAGAMR
What is the function of this protein?
Involved in the degradation of the Pseudomonas aeruginosa quorum sensing signal molecules HHQ (2-heptyl-4-quinolone) and PQS (2-heptyl-3-hydroxy-4-quinolone) to anthranilic acid.  Catalyzes the cleavage of PQS to form N-octanoylanthranilic acid and carbon monoxide.
What are the official names of this protein?
2-heptyl-3-hydroxy-4-quinolone dioxygenase AqdC1, PQS dioxygenase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily.
Protein: HSP7D_DROME
Sequence: MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQTIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEEVD
What are the official names of this protein?
Heat shock 70 kDa protein cognate 4, Heat shock 70 kDa protein 88E.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Nucleus. Note=Localized to a meshwork of cytoplasmic fibers around the nucleus. Translocates to the nucleus after thermal stress.
Protein: RPIA_LEGPA
Sequence: MSELKIKAAKAAIAYIEDDMVIGVGTGSTVNFFIKELAAIKHKIEACVASSKATEALLRAEGIPVIDLNSVQDLPIYVDGADEVNERGEMIKGGGGALTREKIVANVATQFICIVDESKVVKRLGEFPVAVEVVPMARSFVARQIVKLGGDPEYREGFVTDNGNIILDVFNLNFSTPMALEDSLNVIPGVVENGVFAKRLADKVLVASASGVNNLK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: PP4R2_YEAST
Sequence: MSSTMLDDVDNNMMGIKSISLYELLSDVVKQGDKTRLVTAGPEQVLPDLIRHITETIPFDLFINLKNEMNDARNLVTRLNWLGKFLNDNFLQNHTFPFTILRICELCYDPFKYYKINELEKFVNALEKCCMVTSSWQVFDKTHGEKQEDDKEKDINFIKNQEDVSLMKIPWMTENNTRELAPFIREIDSIMSVNLGYDDEDEEEGFFDGDEDREMGNKSKRNVLLKDENFMVEEYYEDDCGINDDNSDNKGQNCQSDVTKNNSDDEDDDDNDDDYREDGADEDDEDDDHMGSTDDDEDDDEDRQAGESTKVQNFDKKNETPRKRKPTDLDNFEYDESPSFTNMDLTTPKKYKHTATGRFSIIESPSSSLLNAMDGSNEISSSQEEEKEDAHENHEGRSEGLLPGDELVSPSMSSSQEDKMVAIAGITYRENISSPLGKKSR
What is the function of this protein?
Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process.  Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 regulatory subunit 2, PP4R2.
What is the protein family that this protein belongs to?
Belongs to the PPP4R2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: UVRD_RICCN
Sequence: MQNQDFIHTLNPEQQKAVLHTEGPLLLLAGAGTGKTKVLTSRIANIIHQNLASPQNILAVTFTNKAAKEMAERVNSLINCYGLNIGTFHSMAARILRDQIEHLNLGLNNRFTIISHDDQLKLVKDIVKLKDIDTKKYAPKLIHIIISRWKDQGLLPTKLSVSDTNLPLQRVAKLVYEEYQKNLLISNVLDFGDLLLYNNELFIKNSEILRYYQEKYRYILIDEYQDTNVVQYLWARMLASLYKNICCVGDDDQSIYGWRGAEVGNILRFEKDFAGATIIKLEQNYRSTLPILAAASNVINNNKNRHGKTLWTDRENGEKIKIISCWSDKEEARYIAGEIDKLVRENRYNAGNIAILVRAGFQTRSFEEAFINSAMPYKIIGGLRFYERMEIRDVLAYIRISLNQNDNLALERIINVPKRAIGAASLNKIRGYALERNISNFAAIKEMLEIGEIKAKSYETLKDLVTKIDNWYERFSIDAPINVVKAILDDSGYLEMLQEEKTEEAFGRIENINEMLRAIAEFNDVHDFIEHSSLVMENEVLETNYGGSVTIMTLHAAKGLEFDVVFLPGWEEGVFPSQRSLDEEGEKGLEEERRIAYVGITRAKKDLYITHAESRKIFYEIVRSYPSRFITEIPDEITIRTSSMKKYNSFYKF
What is the function of this protein?
Has both ATPase and helicase activities.  Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present.  Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity).
What are the official names of this protein?
Probable DNA helicase II homolog, DNA 3'-5' helicase II.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: PANE_STRP8
Sequence: MLVYIAGSGAMGCRFGYQISKTNNDVILLDNWEDHINAIKENGLVVTGDVEETVKLPIMKPTEATQEADLIILFTKAMQLPQMLQDIKGIIGKETKVLCLLNGLGHEDVIRQYIPEHNILMGVTVWTAGLEGPGRAHLQGVGALNLQSMDPNNQDAGHQVADLLNKANLNATYDENVVPNIWRKACVNGTMNSTCALLDCTIGELFASEDGLKMVKEIIHEFVIVGQAEGVELNEEEITQYVMDTSVKAAHHYPSMHQDLVQNHRLTEIDFINGAVNTKGEKLGINTPYCRMITELVHAKEAVLNIQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
What are the official names of this protein?
2-dehydropantoate 2-reductase, Ketopantoate reductase, KPR.
What is the protein family that this protein belongs to?
Belongs to the ketopantoate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWI6_CRYNH
Sequence: MPVIKKEELSQKKDLESEEEDSGLEDEYEVEKVIKHRGKGKNIEFLVRWKGYGPEYDTWEPTENVASAEEAVAAYWETQDKTATAPRKRGRQEAYTASQTSITPKPESSKQAAKKARTSTAENGIKASVDKGEGNDGASDDDIDRQYSGSLDKYSDLKSWENVVQNIETVEQGEGGQLIVYATMKGGEKVTIPTELAYKKCPLKCLYFYQKHLKWRPVDENE
What is the function of this protein?
Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (By similarity).  Localizes DMT5 to heterochromatin characterized by trimethylation of histone H3 tails at 'Lys-9' (PubMed:31955845).
What are the official names of this protein?
Chromatin-associated protein SWI6.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTAG_PESFW
Sequence: MASTGSAQKETLNKFISGWKNANAEEMLAVASDDYTQQTLPFSLGHDVRPKQVAEVMLPKLYSILENYELKIHQVVHDVENQKAAVYAISKADTPFGFPWLNEFSAFITFNNAGDKVVNVQEMVDTEFFQKFFPAYQSFLSQNK
What is the function of this protein?
Monooxygenase; part of the gene cluster that mediates the biosynthesis of pestheic acid, a diphenyl ether which is a biosynthetic precursor of the unique chloropupukeananes (PubMed:24302702).  The biosynthesis initiates from condensation of acetate and malonate units catalyzed by the non-reducing PKS ptaA (PubMed:24302702).  As the ptaA protein is TE/CLC domain-deficient, hydrolysis and Claisen cyclization of the polyketide could be catalyzed by ptaB containing a beta-lactamase domain (PubMed:24302702).  The ptaB protein might hydrolyze the thioester bond between the ACP of ptaA and the intermediate to release atrochrysone carboxylic acid, which is spontaneously dehydrated to form endocrocin anthrone (PubMed:24302702).  Endocrocin anthrone is then converted to endocrocin, catalyzed by the anthrone oxygenase ptaC (PubMed:24302702).  Spontaneous decarboxylation of endocrocin occurs to generate emodin (PubMed:24302702).  An O-methyltransferase (ptaH or ptaI) could methylate emodin to form physcion (PubMed:24302702).  PtaJ could then catalyze the oxidative cleavage of physcion, and rotation of the intermediate could then afford desmethylisosulochrin (PubMed:24302702).  PtaF, a putative NADH-dependent oxidoreductase, might also participate in the oxidative cleavage step (PubMed:24302702).  Desmethylisosulochrin is then transformed by another O-methyltransferase (ptaH or ptaI) to form isosulochrin (PubMed:24302702).  Chlorination of isosulochrin by ptaM in the cyclohexadienone B ring then produces chloroisosulochrin (PubMed:24302702).  PtaE is responsible for the oxidative coupling reactions of both benzophenones isosulochrin and chloroisosulochrin to RES-1214-1 and pestheic acid respectively, regardless of chlorination.
What are the official names of this protein?
Monooxygenase ptaG, Pestheic acid biosynthesis cluster protein G.
What is the protein family that this protein belongs to?
Belongs to the avfA family.
Protein: GLB74_CHITH
Sequence: MKFFAVLALCIVGAIASPLTADEASLVQSSWKAVSHNEVDILAAVFAAYPDIQAKFPQFAGKDLASIKDTGAFATHATRIVSFLSEVIALSGNASNAAAVEGLLNKLGSDHKARGVSAAQFGEFRTALVSYLSNHVSWGDNVAAAWNKALDNTMAVAVAHL
What are the official names of this protein?
Globin CTT-VIIB-4, Erythrocruorin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PYRC_ALIFM
Sequence: MTTLTITRPDDWHLHLRDGDVLTDTVRDSGRYNGRALIMPNLVPPVTTTEQALSYRERIQAENKSDSFAPLMSLYLTEKTTSEEIRKAKATGHIVAAKLYPAGATTNSDSGVSDIKKVYPILKTMQEEGMLLLIHGEVTTHDVDIFDREKTFLDTVLAPIVNDFPELKIVLEHITTKDAADFVKNAGPNVAATITAHHLLFNRNHMLVGGIKPHFYCLPILKRNTHQQALVEAATSGNPKFFLGTDSAPHAKDKKEAACGCAGSYTAHASIELYAEVFENEGKLENLEAFASFNGPDFYNLPRNTDTITLVKEAWIAPETMAFGNDFVVPIRAGEAVEWLVK
What is the function of this protein?
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
What are the official names of this protein?
Dihydroorotase, DHOase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.