Protein: LEPA_ASPFN
Sequence: MGSLSDVRVEPIAIVGSACRFPGGANSPSKLWDLLHSPRDVLMDFPPSRLRLSNFYHKDGEHHGSTNVINKSYLLAEDPNVFDAAFFNINGLEAQAMDPQHRILLETVYEALERGGCSLDDIQGTKTSVFVGVMNADYYDIQLRDSETMARYNATGTARSIISNRISYFFDLKGASMTIDTACSSSLVALHQAVLSLQNREAEASIVAGANLLLDPTMYIAESNLHMLSPEARSRMWDKDANGYARGEGFAAVYLKPLSAALRDGDEIECIIRGTGVNSDGRTKGITMPSSVAQTELIRDTYRRAGLDPSVDRPQFVECHGTGTAAGDPVEARAVHDAFFPPSSKRDNERPLYAGSIKTIIGHLEGCAGLAGVLKASLALQNRIIPPNMHFNDLSPSVKPFYGMIQIPKQPMPWPESTTFRASVNSFGFGGTNAHVILEGYYKGGECLNGGCQQARLDSFVGPMLFSGNTQTTLRAMIKEYFDYLSANPSLDLEGLARALADRRSMFPVRAFFSGSNREALLKYMGQALISSEGSDIGTRSLASSDTPGLLGIFTGQGAQWATMGKALIHSCLLFRVSIENCEESLSTLPDPPSWSLMQELLADDKESRIGQAAFSQPLCTALQIALVDLCSASAITFDAVVGHSSGEIAAAYAAGILSAKDAIRIAYYRGLYAKLASGPDGQPGAMMAVGLSMEGAMSFIAECGLYGKVCLAASNSPSSVTLSGDKDAILQAKGFLDERKVFARQLQVDTAYHSHHMLSCADAYLKSLEACNIKPSLPRAGCVWVSSVRGDIEILEKGDFTSLNSQYWVDNMVKPVLFSQAVECSLWAGGPFDMVLELGPHPALKGPATQTLKSALGTSLPYAGIMRRATNEVEAFSGAIGYVWSHLTDYHIDFASYRESFFKEADRAPATLKDLPSYPWQHDKAYWKESRISRQFRLRHSPLHELLGRRAPDDSDSEMRWRNVLRLSELEWIRGHEFQGQALFPAMGYIAMALEAVTIATKGQQISLVDIEDFHVLQAVVLEEEHPGVEIVFSLKQTGDCKWDFNCYTCSDEWKDLTKTSTGRLILFKGEGSASELPSRPKKRANLSPLDREMFYRKLSSLGLSYHGLFKPQSSFQRSQSYATGSASWPLDQLGQEYVVHPAVMDVALHSIFVAFASPVSHELWATYLPVAIDRLSFNPNISLYGTDGALTIEIDTFITESSSSTMKGDVYLLSPDATPSILIEGVRLQSFTEAKALNDRLLFSKIVWGADIAHGFSSHAVECANKDQFELCDAMERTSLFFLQRAFAELAPCEIEQSEPQFRHLHTAFLKVIEQIKGGLHKSIHSEWLGDSWNDVNSLRRSFESSIDLEMMHAIGQSLPDVIRGRRPLLEVMMRDNLLNRFYTDGRLFVPLNLYVAKTVKAMIHKNPHMKILEIGAGTGATTKAILDTIGDTFDSYTYTDISPGFFAQAQERFALHRQQMRFQTLDIERDTVEQGFERHSYDLVVAANVLHATSHLQETMGHVRSLLRPGGYLLIVEVTGETLQLMYVMGGFPGWWLGVDDGRTDGPGIPAVQWEGLLQMTGFSGIEATVSDLPSDGKHSCSALVSQAIDDKLELFRDPLPRVGDVPIRDPILILGGGTLPVAKLVTGVRKLLRPFRWNIQHAPSVDHLTVPLEGSRSVICLSELDNPLLSEPLTDTRLSKLQAVLGSATNVLWITRDRLTDYPHSNMINGLGRTLQFELPDINIQFLDIRSGISIGADQVVTKFLQLCLVNSPEYLQDDVPWKIEPELSFDGEEWQIPRIIPYKALNDRYNATRRQIMKPLDASRQPVELACFDGRIIIREGKRVTGTSTGSVRLRTILTTRLVSSRLASFFLCMGVEADNGRTAVAITTRMGSLMDIPSTDAWFLPQRSQCDPALLYFIAGQVLAVALSFASPRSGSVILYEPTEALAEAIILSRSWVQEQPYFITSRSGTLQKGWTYIHPRVSHNIARDVLPGDTAALIDCSDDCPHWAVPTTVGKLIPLASCVVEYLTRTPSTFSSIIEHAYSESLLAALPSTAQLSASILSVEDSAGQSSSLLSYPNIVNFDCNNAVLATVAPLDCTGLFSSAKTYWMIGLNSELGLSICRWMIVQGARHIAITSRSGKVDAPWLDEIQSMNGNIKVYPMDVADREAVHSVHQEILRTMPPIAGVCNGAMVLSDKLFMNMKAEDMNKVLKPKVDGSIYLDELFCTTQLDFFILFSSLASVVGNGGQCNYHAANMFMTSLVSQRRSRGLAASVIDIGLVVDVGYVARAGQSLIDHLVNLFYTPLSESDIHKLFAEAVMASPVDSGLCPDIIMGVEPVHDISASLKKPPWYNNPIFSHLRLGTEASSQDSDQSNSTSASIRDQVSSASSVEEGTDVLLRCFAAKLEAMLSLATNSVNVNMPLLDIGVDSLLAVEIRQWFLTKLYVDIPVLKVLSGDTVVEICAEAIQKFAQMSPSAFQGTSSAASKIKQATASPPEIGREEAQSTSRAGILPTDQDNDNSSDSESQRKSGASSSSGSGTRTPTSIDEYFETNVNMLSRSGPMSYAQSRLWFQQQLVKDPTALNIVVRFDVKGYLDVDRLAAAVTATVNRHDALHSAYFAHLDTQEPLQGVIEAPGDIFQHVKVHDDNAASAIFLEMQNRHWDLERGDVFKVTLLTFPTNVQSLIIAYHHIVLDGFSWHVYLRDLSMSYQQQALPPVGPQALDFALIEAQETKNEEYNAQLEFWREELSPVPETFPLLPFSSSKVRQGMQSFQSTTATRELHFDILARAKAASQRLRVTPFHFHLAIAQVLLYKLTNIGDLCIGVTDVNRTNRKFAETVGFFLNLVPLRLRVKPTDSFTEVLHRTSKKALSAMEHSGVPIDVVLRELNIRRSSGHSPLFQVVFNYRVGDMLQVPFGGGRLELHSSIEARSPYDVVFNVTQCPSGASYLQVTSRDALYAPEVSGVICDMYIRLLEDFAGDTSMQIQDGLLNDKSEPGIGLGPRLEFGWPRTMSELFSQRAATDANSIAVKDCRGAVSYAELQQRVADITQDILGCNPPPNARVAVCIHPSRDTIAAMLATLAAGCVYVPIDITLPEARRRAILDSCRPSVILCDSTSADSIDQFAPQECRKVDLGYSPTRATTTAMPEPVADDPAFLLYSSGSTGIPKGILLPQKGYMNYLASKGHHLCLGREVVLQQSSVGFDMSIAQIGNALAHGGTVVVVPQSVRGDPVATAQLMLQEKVTFMIGTPSEYLMLLQHGGDYLRQYRDWRHACLGGESVTEPLKREFRRLSPNCPNVTDCYGPTEISAATSFNTLDLHRGAANEYSTVGRPIPNSTIYILGANGDIVPPGLVGEICIGGVGVALGYWNLPDLEKQKFIHDPFASSADRRRGWTRLYKTGDRGRLGPDGGLIFMGRLDGDTQIKLRGLRIDLEEVANSLLQVAAGLLSETVVSVRGDPEFLVAHAVPARGQKVTNSDLESFKRSLPLPQYMCPAAIVLLDRLPTTPNGKVDRKALQDKPLPTEPDSSFPTEALSLAEGELRLVWQDVLQQTAQTGRIDSRTDFFMAGGNSLLLVKLQGAIKNAYGLSIALKDLYRCSTLGRMATLIDAEKKNQPIFEKIDWEDETRVPGSLARGQRSREPKKTDLHIALTGSTGFLGMEILKALLEQPTVSKVHCLAVDAQHGQSLPKSHKIVIYPGSLNVSALGLSTREVDFLKSTVDALIHAGANGHCLNNYFSLRMPNLGSTRFLTELALSRGVPLHYVSSNRVTLLSGDVALPPGSMSAFPPPETGSDGFTASKWASERYLENVAEATGLDVCIHRPCALTGDQAPSEDALNAILRFSVLMKVVPQFPNVRGFFDFEKVGVVATNIVKKALQSVQVTRVHATSVASFAHHSSGVKVPIDKIQDRMQDLYGGVFGRLALADWVQRARTLGIEPLVASYLEAMESRGEEMAFPFLGMPSD
What is the function of this protein?
Hybrid PKS-NRPS synthetase; part of the gene cluster 23 that mediates the biosynthesis of a family of 2-pyridones known as leporins (PubMed:20447271, PubMed:26051490).  The hybrid PKS-NRPS synthetase lepA and the enoyl reductase lepG are responsible for fusion of phenylalanine with a hexaketide and subsequent release of the stable tetramic acid precursor, pre-leporin C (PubMed:26051490).  Because lepA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase lepG (PubMed:26051490).  It is possible that the dehydrogenase lepF also participates in production of pre-leporin C (PubMed:26051490).  Cytochrome P450 monooxygenase lepH is then required for the ring expansion step to yield leporin C (PubMed:26051490).  Leporin C is then presumably further oxidized by the N-hydroxylase lepD to form leporin B (PubMed:26051490).  LepI may possess a function in biosynthesis upstream of lepA (PubMed:26051490).  Leporin B is further oxidized in the presence of ferric ion to give the leporin B trimer-iron chelate, but whether or not this reaction is catalyzed by an enzyme in the pathway or by ferric ion is not determined yet (PubMed:26051490).
What are the official names of this protein?
Hybrid PKS-NRPS synthetase lepA, Leporins biosynthesis protein A.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NRP synthetase family.