PharMolix/UniProtQA huggingface dataset:
Protein: TRPG_CRYNH
Sequence: MGFTLLIDNYDSFTWNIYADLASVGGNPFVVRNDKITLKEIEGMFADGELERIVISPGPGHPRTDSGVSRDVIAWGMGKLPILGVCMGLECIVDLLGGEIAYAGEIKHGKTSLVQHDSIGVFHNLPQFLSSTRYHSLSAQIQSLPSVLQVTSTTKESGVIMGVRHRTFTVEAVQYHPESCMSEGGRGLMANFIQMKGGKWGGENAWCGVPAEGEGEQPKAKTNGAPSLPTILNKIHAQRLLDVEQAEKIPATTPANVSTSLSLYTSPPLINFRGRMVSTPHTAVMAEIKRASPSKGDIAPTASAPQQALKYALAGASVISVLTEPTWFKGSLLDMLAVRNAVDSLPNRPAILRKDFVLSKYMIDEARLYGADTVLLIVAMLEPQQLKELYDYSVSLGMEPLVEVNNPTELSLALEIGSKVIGVNNRNLHDFNVDMSTTSRVNAALNGRDVVLCALSGISSHEDVEKYVKEGVKGVLVGEALMRASDTKAFLRSLIGLPPLEVVPKPRPLVKICGIRSTNDAKLAINAGADLLGVILVPGTKRCISTSTAREISALVQSARSQSSSKPLEPSLSSPWFTSQSALLSSRRKPLLVGVFQNQSLSDILSAVDEIGLDLVQLHGDEPQAWAKFIPVPVVKVFRVSPEGIVRGGEIRRPGLNQAILLDAGGASGGGGEGKAFPWEHAKRLIQSGEVGSEGHVPLPVILAGGLTPENVGQAIEQAGEGVWCVDVSSGVEGEGGKVKEKVEAFVKAVRG
What is the function of this protein?
Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
What are the official names of this protein?
Multifunctional tryptophan biosynthesis protein.
Protein: CP2_ARATH
Sequence: MSSEQREGSQETTTTTVEGNGTIAGQNSHSAAPTTLRATSTMVSCQRLRLNPNNEHRPDSYEDLQLDFPNSVYSSLEKYLPPNMLVSNRDEKIKFMTDIMLRHLPHGERSRAQRHSDYRLKITTNYQPLHKELYTLVPTVCFVPAFLKAINENTEESFRNIISEPSPGVFVFDMLQPSFCEMMLAEIDNFERWVGETKFRIMRPNTMNKYGAVLDDFGLDTMLDKLMEGFIRPISKVFFSDVGGATLDSHHGFVVEYGKDRDVDLGFHVDDSEVTLNVCLGNQFVGGELFFRGTRCEKHVNTATKADETYDYCHIPGQAVLHRGRHRHGARATTCGHRVNMLLWCRSSVFRELKTHHKDFSSWCGECFCEKRDEKVRSIDALRKKLFKPRQTQA
What is the function of this protein?
Participates in the epigenetic repression of flowering genes in association with ICU11 (PubMed:29915151).  Functions in the repression of several members of the MADS-box transcription factors family, including SEP3, during vegetative development via histone modification (PubMed:29915151).
What are the official names of this protein?
2-oxoglutarate and iron-dependent oxygenase domain-containing protein CP2, Protein CUPULIFORMIS 2.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: APAH_DECAR
Sequence: MATYAIGDIQGCYDSLQRLLERCAFDPASDRLWLVGDLVNRGPKSLATLRLIKSLGPAALTVLGNHDLYLLMVAEGGAKFRGKDDTLQEILDAPDCAELLDWLRHQPICHTEGEYCLVHAGLLPQWTASRARELAREVEITLQGPDFREFILNLWGSEPAGWSDNLSGWARLRVIVNAMTRMRFCTLDGVMEFKVKGKLSNAPAGHIPWFDLPDRKSAKSVLVTGHWSALGLKVTPNLLALDSGCLWGGHLTAVRLEDRQVFQVDCSPTEALPLKR
What is the function of this protein?
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
What are the official names of this protein?
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical, Ap4A hydrolase, Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase, Diadenosine tetraphosphatase.
What is the protein family that this protein belongs to?
Belongs to the Ap4A hydrolase family.
Protein: SHRM3_MOUSE
Sequence: MKTPENLEEPSATPNPSRTPTERFVYLEALLEGGAPWGFTLKGGLERGEPLIISKIEEGGKADSVSSGLQAGDEVIHINEVALSSPRREAVSLVKGSYKTLRLVVRRDVCAAPGHADPGTSKSLSSELLTCSPQHRKATWSGGVKLRLKQRCSEPATRPHSWHTTKFGETQPDVSMMQISQGTMGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGGYPPCHLLSPAKSTSSIDQLGHLHNKRDSAYSSFSTSSSIFEYPPPGGSARERSGSMDVISARGGLLEGMRQADIRYVKTVYDTRRGVSSEYEVNPSALLLQGRDAHASADSQGCAKWHSIPRGKGTPSPSWSQQCSGSLETATDNLPQKAGAPLPPTRSDSYAAFRHRERPSSWSSLDQKRFCRPQTNSSGSQKTPFAEDQLHTVPERSPENSPPVKSKHNYTQKAQPGQPLLPTGIYPVPSPEPHFAQVPQPSVSSNGTVYPALVKESGYTAAQGTCNKMATLDENGNQNEASRPGFAFCQPLEHNSVTPVEKRPEPTAKYIYKVHFSSVPENEDSSLKRHITPPHGHSPYPSERKNIHGGSRACSNHHSLSSPQAQALHVGDDRRPSRLSQPWEGDFQEDHNANLRQKVEREGQGQGLSGNSGRTRSAFSSLQNIPESLRRQSNVELGEAQEVHPGGRSKVEDPGRKAGASDIRGYLDRSVSYPRPEGKMNAVDSVHSADSRYEESPAPALPQTSGASQRRLSSSSSAAPQYRKPHCSVLEKVSRIEEREQGRHRPLSVGSSAYGPGYRPGRTGPTPSTSSSDLDDPKAGSVHFSESTEHLRNGEQNPPNGEAKQEEASRPQCSHLIRRAPADGRGPPARGGEPSRPEARLLRSQSTFQLYSEAEREASWSEDRPGTPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLEPGTPATSRPWRPRPASAHVGMRSPEAAVPSSSPHTPRERHSVTPAAPQAARRGPRRRLTVEQKKRSYSEPEKMNEVGVSEEAEPTPCGPPRPAQPRFSESTVADRRRIFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTGAACTPEAGLRERAQSAYLQAGPAAPDGPGLASACSLSSLREPEALPRKEHTHPSAADGPQAPRDRSSSFASGRLVGERRRWDPQVPRQLLSGANCEPRGVQRMDGAPGGPPSWGMVAGKAGKSKSAEDLLERSDTLAVPVHVRSRSSPTSDKKGQDVLLREGSNFGFVKDPCCLAGPGPRSLSCSDKGQNELALPLHHPTPCWNGSGCKATVASSAPPESSGAADHLKQRRAPGPRPLSAGMHGHFPDARAASLSSPLPSPVPSASPVPSSYRSQLAMDQQTGQQPPSSPASAVTQPTSPRSPELSSPAYGLGEGMWKRTSLPQRPPPPWVKWAHAVREDGLAEDTLAPEFANLKHYRNQPSRPSSCSTSDPDTPGRISLRISESALQPSPPPRGDYDDEVFMKDLHPKVTSSPTFEALPPPPPPSPPSEEPLVNGTDDFPPPPPPQALCEVLLDGEASTEAGSGPCRIPRVMVTREGHVPGAAHSEGSQIMTATPPQTSAKGSEAESNTPSSASAQPQLNGSPGKQLCPSQTRNLTYEPVERTQDLGKKTHAEPQKTSEDIRTEALAKEIVHQDKSLADILDPDSRMKTTMDLMEGLFPGDASVLMDSGAKRKALDITARRAGCEAKASDHKEAVSVLVNCPAYYSVSAAKAELLNKIKDMPEELQEEEGQEDVNEKKAELIGSLTHKLESLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYKMFIGDLDKVVNLLLSLSGRLARVENVLRGLGEDASKEERSSLNEKRKVLAGQHEDARELKENLDRRERVVLDILANYLSAEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVRCLLESLPSDFRPKAGAISLPPALTGHATPGGTSVFGGVFPTLTSPL
What is the function of this protein?
Controls cell shape changes in the neuroepithelium during neural tube closure (PubMed:10589677, PubMed:14680628).  Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (PubMed:14680628, PubMed:16249236, PubMed:16684770, PubMed:22493320).  Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity).
What are the official names of this protein?
Protein Shroom3.
What is the protein family that this protein belongs to?
Belongs to the shroom family.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin in stress fibers and adherens junctions.
Protein: UVRC_SHEHH
Sequence: MSDVFNANQFLKTVTSSPGVYRMYDAKAVVIYVGKAKDLKKRLSSYFRKNLTNVKTQALVSHIANIDVTVTHSETDALILENDYIKQYMPKYNVLLRDDKSYPYILLSNHKHPRLAYHRGPKRDKGLYFGPYPNGGAVRESLHLLQKIFPIRQCDDLYYKSRSRPCLQYQIGRCSAPCVGKVSLEDYQEQVRLATLFLKGKDHQVMSVLVGKMEQAASDMRYEQAALYRDQITALRRVSEQQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFMLQFYLNSDSQRLTPKEILISEPFEEQDELAKAIQAAQNKKVEIKTQVRGERASFLRLALTNATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDISHTMGESTVASCVVFNREGPSKADYRRYNITGITPGDDYAAMKQAITRRFDKISSSGKIPDILFIDGGIGQLRIAQKVVDEKFVALDNAPTLIGVAKGEGRKPGLETLIYGENEESFTLPADSGALHLIQHIRDESHRFAITGHRNKRQKTRNTSTLESIAGVGPKRRKALLQYLGGLQEVKGASVSELVKVPGISLEMAQTIHDALRG
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LHX1_CHICK
Sequence: MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLNNSNTAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKETGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELLPNGPFSFYGDYQSEYYGPGANYEFFPQGPPSSQAQTPVELPFGAAGGPPGTPLGALEHPLPGHHPPGEAQRFPDMLAHPAGDSPSPEPTLPGSLHSMSAEVFGPSPPFSSISVNGGANYGNHLSHPPEMNEAAVW
What is the function of this protein?
Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.  Acts in conjunction with ISL-2.
What are the official names of this protein?
LIM/homeobox protein Lhx1, LIM homeobox protein 1, Homeobox protein Lim-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: DDL_VEREI
Sequence: MSLFDPHLDGASLGKVAVLMGGVSAEREVSLLSGAGVLRALRARAVDAHAFDTAQGDLGALKREGYARCFIALHGRHGEDGTVQGALELLGIAYTGSGVMASSMALDKTMSKRIWRSEGLPTPDWRLVTSGAEAGQALQTLGAPMIVKPAREGSTIGLSKVHQAQQCASAYLLAARYDPEVLCEQFIAGDELTCTVLDQGRRASAQALPLIRIVAPDGNYDYQHKYFSDATRYHCPSGLPEAQERAIGRLAEQAFSALGCRGWARADIMLRASDQQPFLLEINTAPGMTDHSLVPMSARAAGISYEDLCLRLLAMATLDTPPGALSGAARA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_BACLD
Sequence: MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEDGVHVFKEKGRIADLRAAVDANVKSQAGIGHTRWATHGEPSRLNAHPHQSASGRFTLVHNGVIENYVQLTREYLHDVTLKSDTDTEVVVQVIEQFVNNGLDTEEAFRQTLMLLKGSYAIALFDHENKETIYVAKNKSPLLVGLGDNFNVVASDAMAMLQVTNEYVELMDKEMVIVTDKKVVIKNLDGELMSRASYIAELDASDIEKGTYPHYMLKEIDEQPLVMRKIIQTYQDENGKLSIPGDISNAVAEADRVYIIACGTSYHAGLVGKQFIETWAKVPAEVHVASEFSYNMPLLSEKPLFIFISQSGETADSRAVLVQVKKLGHKALTLTNVPGSTLSREADYTLLLNAGPEIAVASTKAYTAQIAVLAILAAVTAESRGKELGFDLVKELGIIGNAMEALCDQKDEMEMIAREYLTVTRNAFFIGRGLDYFVCLEGSLKLKEISYIQAEGFAGGELKHGTIALIEDGTPVIALATQEHVNLSIRGNVKEVTARGANPCVISLKGLEEADDRFVLPEVHPELAPLVSVIPLQLIAYYAALHRGCDVDKPRNLAKSVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VP24_NPVOP
Sequence: MANADSLDARAFSYAPDASFEVIIITNAPNDHDGYLELNAAARLLAPFQKNISALWTSAAPSHKLVRNNKNYLHVFGLFKYLQNYNFNAKPHPPEYYTVKSVICDLIAGAQGKTFDPLCEIKTQLCAIQESLNEAIVTLNSHATAEPAPGAPCDARELVETLHSEYSQKLTFATDTILDNVKSIKDLVCLNK
What are the official names of this protein?
Capsid protein p24.
What is the protein family that this protein belongs to?
Belongs to the baculoviridae p24 family.
What are the subcellular locations of this protein?
Virion.
Protein: KHSE_BURCM
Sequence: MAVFTAVSDSDLAQWMRHYELGDVLAFRGIPSGIENSNFFLTTTRGEYVLTIFEKLTAEQLPFYLDLMRHLASHGVPVPDPIPRDDGALFGLLHGKPAAIVTKLDGAAELAPGIEHCIEVGQMLARLHLAGRDYARYQPNLRSLPWWRENVPAIVPFVSDAQRTLLEGELAHQAAFFASDDYAALPSGPCHCDLFRDNVLFAHAAPGTGHDVRLGGFFDFYFAGCDKWLFDVAVTVNDWCVDLATGVLDVARADALLRAYQTVRPFTAPERRHWSDMLRAGAYRFWVSRLYDFYLPRAAEMLKPHDPGHFERILRERIANTPALPETHTACN
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the pseudomonas-type ThrB family.
Protein: MS116_CANAL
Sequence: MLKQLSRSLGIRSSPIVANLIRSKQVCTRGFHISLVKQNTSSKVNEITDITSDSLKVKEDAAGSDLPSTKTDKKSKSESFQPVKFEDFKGKGYIHDSIINSLHKNDFKELTPIQQKSLVPIFNTEKGLVCRAKTGTGKTLAFAVPTLQYAYKNRGKGVSTVVLVPTRDLAFQIEEEYRKLISHLKYNERPNLELIIGGQRTSFNPRRPAEIVIATPGRLEKELQTDRKLAKCFSNVTYRIYDEADRLLDVGFESVLNEIDGLLYKVRTTPKPIKSLLFSATVDEAISEFSKKHIHPEYEFLNTVTKDDLEIPENIHQQLIECTDGIDKVNVSLSELHGIMKQHNDYKVIVFLPTKTAVDWFYEYITNALDDELFELFSKPPRVFMLHGGRSVRQRSAALKGFKVAKKGILISTDVAARGIDVKDVTNVMQMFPSVEIADYIHKVGRTGRAGKKGKASLFATPAELPYVSLLKRKRKVKFQEVIQSEKLNSSNIIDQIESPLDSTKEFLATMVGYLQQLQSAHRLDYDSLVIENMELYRKLVRDDKAMLESRILSRIGKGISAHVKRRYFTRTRYQSHDDAEFDSYSDFSRSGMSQRPRSNDRSSKMTFNGRGKYGNNRNNDWSYQNKNRYNNNNNRQTERSYDSDRKSHNDWKYEKKFEHRRIRDHDE
What is the function of this protein?
ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns.  Also required for efficient mitochondrial translation (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase MSS116, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: UBIA_COXBR
Sequence: MINLRQQMPHYLRLMRFDKPVGIFLLLWPTLWAVWIAAKGAPSFKIAVIFIAGSVVMRAAGCIVNDFADRHLDKHVQRTQMRPLASGSVSVTEAMLLFAVLSLIAFTLVLLLNRLTVELAVIGILLALVYPFLKRFTHLPQLWLGVAFSWSIPMAFAATVGHVPAVAWLLFFAAVLWPIVYDTQYAMIDREDDVKVGIKSTAILFGRYDRLMIGLLQGSVLLTFGLLGWYLRFNYWFYLGLLVALGLMCYQQFLIRHRKPPDCFAAFRNNNWVGFFIFLGILLTHRN
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CCD89_RAT
Sequence: MPQKEKTLRMDTPPPDEILGRQNENLENEDDELGFKEMDGLREALANLRGLSEEEKGEKAMLRSRIQEQSQLICILKRRSDEALERCQILELLNSELEEKRMQEMEKMKVQNEQVQKLESRFMTLAANHELMIRFKDEHKSENIKLKEENEKLRQENNSLFSQALKDQENKVLQLTAHNKALVEELEVLKQRCAHEAGQARAREEELLALQNQQACEHAKETEQLRSQLQSIKQQHRQATEQMGKDQEANINMNQELQARLHTVMREKEELLQLSMERGKVLQNKQAEIRQLEEKLETAAMAKKHALERFEQEAVAVDSNLRVRELQRKVDGIQKAYDDLRLQSEAFKKHSLDLLSKERELNAKLRHLFP
What are the official names of this protein?
Coiled-coil domain-containing protein 89, Bc8 orange-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the CCDC89 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1.
Protein: CR3L1_MOUSE
Sequence: MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFVENMEDFSNDLFSSFFDDPVLDEKSALLDMELDSPAPGIQAEHSYSLSGDSAPQSPLVPVKMEDTTQDVEHGAWALGNKLCSIMVKQEQSPELPVDPLAASSAMAAAAAMATPPLLGLSPMPRLPIPHQAPGEMTQLPVIKAEPPEMSQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTAISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETYTSENNELWKKVETLETANRTLLQQLQKLQTLVTSKISRPYKMAATQTGTCLMVAALCFVLVLGSLVPCLPAFSSGSMTVKEDPIAADSVYAASQMPSRSLLFYDDGAGSWEDGRGALLPVEPPEGWELKPGGPAEQRPQDHLRHDRADSIHETTKYLRETWPEDTDDNGTSPNFSHPEWFHDRDLGPNTTIKLS
What is the function of this protein?
Transcription factor involved in unfolded protein response (UPR).  Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity).  In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane.  In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2.  The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes.  Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins.  Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription.  Does not regulate COL1A1 in other tissues, such as skin (PubMed:19767743).  Required to protect astrocytes from ER stress-induced cell death.  In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (PubMed:15665855).  Inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity).  Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (By similarity).
What are the official names of this protein?
Cyclic AMP-responsive element-binding protein 3-like protein 1, cAMP-responsive element-binding protein 3-like protein 1, Old astrocyte specifically-induced substance, OASIS.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. ATF subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Nucleus. Note=Upon ER stress, transported into the nucleus.
Protein: BIOB_GLAP5
Sequence: MTTYSLRLKAKNELTPHPTAQYWRKCQVEELFDLPFMDLVFRAAEIHRQHFDPNAIQLSTLLSIKTGGCAEDCEYCPQSARYDTGVEKQSMLDVNYIVEKAQIAKARGASRFCMGAAWRGPKPKDIETVSAIIKAVKSLGLETCGTFGMLEEGMAEDLKEAGLDYYNHNLDTDPERYHQVIHTRSHDDRMDTLGKVRSAGLKICCGGIVGMNETRAERAGLIASLANLDPQPESVPINQLVKVAGTPLENAEDLDWTEFVRTIAVARITMPKSYVRLSAGRSNMPEAMQALCFMAGANSIFYGDKLLTTENPEEDGDRVLMEKLNLYPLSCSNVE
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: HSLU_SHIFL
Sequence: MSEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDAAVKMVRVQAIEKNRYRAEELAEERILDVLIPPAKNNWGQTEQQQEPSAARQAFRKKLREGQLDDKEIEIDLAAAPMGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKARKLKIKDAMKLLIEEEAAKLVNPEELKQDAIDAVEQHGIVFIDEIDKICKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFERILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNESTENIGARRLHTVLERLMEEISYDASDLSGQNITIDADYVSKHLDALVADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Heat shock protein HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL17_CAMLR
Sequence: MRHRHGYRKLGRTSTHRAALLKNLTIAIIKAGKIETTLPKAKELRGYVERLITRARKGDFNAHRAVFASLQDKEATNKLVTEIAPKFADRNGGYTRIIKTRIRRGDAAEMAFIEFVA
What are the official names of this protein?
50S ribosomal protein L17.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL17 family.
Protein: RPO11_ARCFU
Sequence: MEVKIIDIGEDYVRLVIKGEGHTYLNLLQHYLVEDEDVIVARYNIPHPLIGEPEIYIKTSGVDPLEAVKRANEKIIAACNTLLEQL
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit L.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y311_TREPA
Sequence: MTGELMLRLPCWSSFCEKTHPPLHPGTSLSSTASIACATHPHHTKGV
What are the official names of this protein?
Uncharacterized protein TP_0311.
Protein: OBG_AERHH
Sequence: MKFVDEVQIRVDAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDVYLVADENLNTLIDYRFERFHAAERGENGQSANCTGRRGKDRILRVPVGTRASDEDTGELLGDLTHHEQKLLVAKGGFHGLGNTRFKSSVNRAPRQKSNGTPGEVRTLKLELLLLADVGMLGLPNAGKSTFIRAVSAARPKVADYPFTTLVPNLGVVRGENSRSFVIADIPGLIEGAAEGAGLGIRFLKHLERCRVLIHLVDICPVDGSDPAENAVTIVRELEKYSPELASKPRWLVFNKMDLILEEEAQEVMDRVKTALNHEGPVYAITAISKEGTKKVCYDILDLLDTMPRQLAEDAKDAIEKVEFKWDDYHKNQLAKAEADALAASKAFDESLDDDEWDDEDDDGVEVIYVRD
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATG5_YEAST
Sequence: MNDIKQLLWNGELNVLVSIDPSFLMKGSPREIAVLRIRVPRETYLVNYMPLIWNKIKSFLSFDPLTDSEKYFWFEHNKTPIPWNYPVGVLFDCLAGKSATFTTSFENQVKDVLTFLRIHLVMGDSLPPTIIPIASSKTQAEKFWFHQWKQVCFILNGSSKAIMSLSVNEARKFWGSVITRNFQDFIEISNKISSSRPRHIPLIIQTSRTSGTFRISQPTISMTGVNPTLKDIEGDILDVKEGINGNDVMVICQGIEIPWHMLLYDLYSKLRSFDGFLYITLVPIKGGDKASSEL
What is the function of this protein?
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.  Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation.  Required for selective autophagic degradation of the nucleus (nucleophagy).  Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production.  Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function.  The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.  ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity.  Plays a role in the regulation of filamentous growth and chronological longevity.
What are the official names of this protein?
Autophagy protein 5.
What is the protein family that this protein belongs to?
Belongs to the ATG5 family.
What are the subcellular locations of this protein?
Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localizes to the isolation membrane (IM), a membrane sac which is generated from the pre-autophagosomal structure (PAS). Ultimately, the IM expands to become a mature autophagosome. Localizes also to a dot at the junction between the IM and the vacuolar membrane, termed the vacuole-IM contact site (VICS). Correct localization to the PAS requires ATG21.
Protein: CLPC_STAS1
Sequence: MLFGRLTERAQRVLAHAQEEAIRLNHSNIGTEHLLLGLMKEPEGIAAKVLETFEITEEKVVEEVEKLIGHGQEQMGALHYTPRAKKVIELSMDEARKLHHNFVGTEHILLGLIRENEGVAARVFANLDLNITKARAQVVKALGSPEMSNKNAQANKSNNTPTLDSLARDLTVIAKDGTLDPVIGRDKEITRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQAIVNNEVPETLKGKRVMSLDMGTVVAGTKYRGEFEERLKKVMEEIHQAGNVILFIDELHTLVGAGGAEGAIDASNILKPALARGELQCIGATTLDEYRKNIEKDAALERRFQPVQVDEPTVEDTIEILKGLRDRYEAHHRINISDEALVSAAKLSHRYVSDRFLPDKAIDLIDEASSKVRLKSHTTPPNLKEIEQQIEQVKNEKDAAVHAQEFENAANLRDKQTKLEKQYEEANTNWKNTQNGDNTSLSEEDIGEVIAGWTGIPLTKINETESDRLLNLEDTLHNRVIGQKDAVTSISKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESMFGEDDAMIRVDMSEFMEKHAVSRLVGAPPGYVGHDDGGQLTEKVRRKPYSVILFDEIEKAHPDVFNILLQVLDDGHLTDTKGRRVDFRNTVIIMTSNVGAQELQDQRFAGFGGATEGQDYESIRKTMMKELKNAFRPEFLNRVDDIIVFHKLSKDELKQIVTMMVNKLTNRLSEQDINISVTEAAKEKIAEEGYDPEYGARPLIRAIQKTVEDNLSELILDGNQIEGKEVKIDHDGKEFKYDITERQDSAKDKETSES
What is the function of this protein?
Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpC.
What is the protein family that this protein belongs to?
Belongs to the ClpA/ClpB family. ClpC subfamily.
Protein: Y1317_BACP2
Sequence: MTRIGVEPSLSDVEELLKQKGYDVVRIQNEQQMDQCDCYVVTGLDSNVLGISDTTTKASVITASGMTADEICQEVEQRVQ
What are the official names of this protein?
UPF0180 protein BPUM_1317.
What is the protein family that this protein belongs to?
Belongs to the UPF0180 family.