PharMolix/UniProtQA huggingface dataset:
Protein: BANP_HUMAN
Sequence: MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRLEINCQDPSIKTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENVISNAVPGRRQNTIVVKVPGQEDSHHEDGESGSEASDSVSSCGQAGSQSIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELPQPQPQPQALHYALANAQQVQIHQIGEDGQVQVGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQLLEATRIPCLLAPSVFKASSGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQVQYVQLAPVSDHTAGAQTAEALQPTLQPEMQLEHGAIQIQ
What is the function of this protein?
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function.  Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer.  Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels.  Promotes TP53 activation, which causes cell cycle arrest (By similarity).
What are the official names of this protein?
Protein BANP, BEN domain-containing protein 1, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein.
What is the protein family that this protein belongs to?
Belongs to the BANP/SMAR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NDK_METEP
Sequence: MANERTFSILKPDATRRNITGAVNAVIEAAGLRIVGQRRIRMTREQAEKFYEVHKERPFFGELVEFMTSGPVVVQVLEGENAVAKYREVMGATNPAQAADGTIRKQFAESVGENTVHGSDSADNARLEIAQFFNEADIAA
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_MYCPA
Sequence: MARLVGVDLPRDKRMEIALTYIYGVGRTRSNEILAATGIDRDLRTRDLTDDQLTHLRDYIEANLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGLPVRGQRTKTNARTRKGPKRTIAGKKKAR
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: YDFW_ECOLI
Sequence: MDNARIDLRSKYYVKPKADHPWLTRRTQSHQQVKPPKLPKKKPDPDKKD
What is the function of this protein?
May be involved in H(2) production during fermentative growth.
What are the official names of this protein?
Protein YdfW.
Protein: PAND_CHLPB
Sequence: MRVHLLKSKIHNAVVTSGDLQYEGSITIDSELLDLANMIPNEKVLCVNNNNGERFETYIIEGKAGSREIQLNGAAARCALPGDEIIIMTFAEIEAREAKSFKPMILIVDKHNNPKRRHLVGEEDNPL
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YVBK_BACSU
Sequence: MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTAWAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEIGTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL
What is the function of this protein?
Probable N-acetyltransferase.
What are the official names of this protein?
Uncharacterized N-acetyltransferase YvbK.
Protein: BOD1_XENTR
Sequence: MAESGSGAGSGSSSVGGVSNPTSLAPGDSQLIALIVEQLKSRGQFDGFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNADMNKNQLRNGLRQSVIQSGMLEAGVDRIISQVVDPKLNHIFRPQIEKAIQEYLAAQTKEEPAPPLPPGPPEPQEQEPPGPSQSVS
What is the function of this protein?
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
What are the official names of this protein?
Biorientation of chromosomes in cell division protein 1, Biorientation defective protein 1, Protein FAM44B.
What is the protein family that this protein belongs to?
Belongs to the BOD1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=Localizes at the centrosomes throughout the cell cycle, only dissociating during cytokinesis. Localizes at the kinetochore from prometaphase until anaphase.
Protein: NRAM_I57A0
Sequence: MNPNQKIITIGSVSLTIATVCFLMQIAILATTVTLHFKQHKCDSPASNQVMPCEPIIIERNITEIVYLNNTTIEKEICPEVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPGKCYQFALGQGTTLDNKHSNGTIHDRIPHRTLLMNELGVPFHLGTKQVCVAWSSSSCHDGKAWLHVCVTGDDRNATASFIYDGRLVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIKEGKIVHIGPLSGSAQHIEECSCYPRYPDVRCICRDNWKGSNRPVIDINMEDYSIDSSYVCSGLVGDTPRNDDSSSNSNCRDPNNERGNPGVKGWAFDNGDDVWMGRTISKDLRSGYETFKVIGGWSTPNSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCINRCFYVELIRGRPQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: GHRB_YERPB
Sequence: MKPSIVLYKSIPTDLHQRLAQHFTVNSFDGLTPDNQPELLAALQQAEGLIGSGGKIDQDFLQLAPNLRAASTISVGYDNFDVEALSQRGIALMHTPTVLTETVADTMMALMLSTARRVVELAERVKAGEWQESIGDDWFGVDVHHKTIGILGMGRIGMALAQRAHFGFSMPVLYTSRRPHEAAEQRFGARHCSLDTLLAEADFLCITLPMTEQTYHMIGREQLAKMKSSAILINAGRGPVVDEQALIAALQDGTIHAAGLDVFEQEPLPVDSPLLTLRNVVAVPHIGSATHETRYNMAACAVDNLINALTGTVKENCVNPQVLITH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase B.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COMC_DICDI
Sequence: MIKKYLFLFFIFLIFNFVLSIQPPLSEYNCLKNFVTKFKLSTKFPTNSTGGYDFCSIVSCNPVNGSINGFLSLQSESTTPTTVTVVGTDLSCLPFNNLNLQNFLISTTLLYTKFFTSCSTLAINSDSITSITQVLAPYETFTIVSKKLNGALKMSNFINQKSILITNSNSTSGYTLVNDALAENKIKLETPNFSGLLSVPDLTGYTSLGYPAFYFSDALEVTSLALANIKTIGAVSSRLYFPSTKTIQFPTSYHNDTSYLTIQGKFTKPTAVIDLSKFVNCRNIQILNYDKTFNINGEIPIKTSPFTDIYYTDGNITKIPIGGTSFVTWSTEQSITIKKSGLSGTLPPLSGVIPTYYDFSGNSISGTLSNTWCNTNIIVTDNLMTGTLPSCIVCHLNNSEVAKKFTGNKFTNLVTSNPPCTTFAPKIKVDKSQKTIILTGTDFGTYTSGWILNTTLSCEKLWTKVTYGSNYTCTYPSTTTLDKVSYFWINFNTPGRNYTFPAISQVPTPNSIIVGTSNSVTISGTFFSTYIGYVTQSISVGSISCTVGTSSFSSITCTLDSAPSTNTEQKLIITTNSLIKEAYISTVVGFNNNKLCPNDCTSSTRGICYMNNGTCKCNSGYVGLDCSGLQCKVPNCSNGGTCNTTVGLCVCDSSHQSLDCSLDFKQCPKGLNSLICSGGGNSCNNQTGICTCNSSHQGLNCSINYKQCPIGSNSLICSGGGNSCNNQTGICKCDSSHQGSDCANDFIQCPLKNSIPCSGHGICNNKTGDCTCDSGFTNQDCSGYTCTSNNCNGHGVCDTSKGICQCYPEWQDIDCQTPFKNCLDPTCSNNGICKNTTGICECNSSHQGLTCSIDFNQCPIGSNSLICSGGSGNICNNQTGICTCDSSHQGPDCGTDFIKCPTQNLTPCNGFGNCNNITGSCSCDQNHQSEDCNIVYKECPIINSLICNGFDNSCNNQTGVCTCDDLHQGLDCGLEYKPCINNCNGNGVCNNQTSICTCYEAYQGETCQFQINQCPNNCTTGGDCDTITGICNCYPLRINNDCSGYECLDPNCGDHGICNDMNGLCICDKGYRGDNCIYVDHYASSVIPTKEEGGTVLIYGLFGEINNDPNVQVGNSNCLISNITSNSIECIIGKGSGIKDISVTQNGFEWIGKSMFNYIKSKQSCPNNCNSNGICNDLQGKCECYPGFTGHDCNSLSKTDLISPSTPKVNENTANGIIENGENKFEIMVITLQEKTFTNGVLKQYNLENNWKLLEIINDENNNIFKFKQNLTDSSEISINLEIIKKDRIINFADYSFEISKDSIKVSINISNYIYSNSLNYLQLHLKSNAYKTNKTSSDDEFDCNLDDGSDAKIDNQDLENSNINHENFVTIIKDNKILNGRYIDHVISDGISTFISSRTIEKDSNSITVGLNLPHCKNCLIDPDFSVLLSTDFKENCSDSNSNNYIIPVSITVSIGGAAVLVGSAIFFYRKKFIENTLKIQLKRLSKNNSSGSDGGNTQS
What is the function of this protein?
Regulates aggregation via a pathway that involves lagC and tgrD1/lagD.  Inhibits lagC and activates lagD expression.
What are the official names of this protein?
EGF-like domain-containing protein comC, Communication mutant protein C.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PEX11_DICDI
Sequence: MAGILSKPNYNQFLESLIKLLAQTSGKDKIAKILQYGAKLLGYIFLKRSKHWVDVMKKLETTSGSARKVWRLGNTLAEQQKILALFKVKNPFAFLNILALIRQSGMYFYWVFDHLILGTNIGLCKFDTVKLGWYSSVSWFFGLLCSIIIDLNTLAIMLKKEKSLRLTITQNKINANNNNIDTHTITSEVENKAIIDQFNEVIKKKNEIYLNCAKNGSDLIIASTLLKIYPFSQGTIGISGIISALIGAYQMWPK
What is the function of this protein?
Involved in peroxisomal proliferation.  Could participate in peroxisomal elongation or fission.  May be involved in parceling of peroxisomes into regular quanta (By similarity).
What are the official names of this protein?
Peroxisomal membrane protein 11 homolog, Peroxin-11.
What is the protein family that this protein belongs to?
Belongs to the peroxin-11 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Multi-pass membrane protein.
Protein: TTPAL_MOUSE
Sequence: MSEESDSLRTSPSVASLSENELPLPPPDPPGYVCSLTEDLVTKAREELQEKPEWRLRDVQALRDMVRKEYPYLSTSLDDAFLLRFLRARKFDYDRALQLLVNYHGCRRSWPEVFSNLRPSALKDVLNSGFLTVLPHTDPRGCHVLCIRPDRWIPSNYPITENIRAVYLTLEKLIQSEETQVNGIVILADYKGVSLSKASHFGPFIAKKVIGILQDGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRNILPKEYGGTAGELDTASWNAVLLASEEDFVKEFCQPMPACDNLLGQPLLPEGLISDAQCDDSMRAMKSQLYSCY
What is the function of this protein?
May act as a protein that binds a hydrophobic ligand.
What are the official names of this protein?
Alpha-tocopherol transfer protein-like.
Protein: AROC_PASMU
Sequence: MAGNTIGQLFQVTTFGESHGIALGCIVDGVPPGLSLSEADIQPDLDRRKPGTSRYTTPRREDDEVQILSGVFEGKTTGTSIGMIIKNADQRSQDYGDIKDRFRPGHADFTYQQKYGIRDYRGGGRSSARETAMRVAAGAIAKKYLREHFGVEVRGFLAQIGDVAIAPQVIEQIDWQQVNSNPFFCPDPSAVEKFDELIRQLKKEGDSIGAKLTVVAENVPVGLGEPVFDRLDADLAHALMGINAVKAVEIGDGFAVVNQRGSAHRDEMTPEGFLSNHAGGILGGISSGQPIVATIALKPTSSITIPGRSVNLANEPVEVITKGRHDPCVGIRAVPIAEAMVAIVLLDHLLRHKAQNR
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: NKG2F_HUMAN
Sequence: MNKQRGTYSEVSLAQDPKRQQRKLKGNKISISGTKQEIFQVELNLQNASSDHQGNDKTYHCKGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPCIGVLEQNNFSLNRRMQKARHCGHCPEEWITYSNSCYYIGKERRTWEERVCWPVLRRTLICFL
What is the function of this protein?
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.
What are the official names of this protein?
NKG2-F type II integral membrane protein, NK cell receptor F, NKG2-F-activating NK receptor.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: TACY_LISMH
Sequence: MKKIMLVFITLILISLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEINYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNSVDNPIE
What is the function of this protein?
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes.  After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex.  Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.  Acts as major virulence factor required for the escape of bacteria from phagosomal vacuoles and entry into the host cytosol.  Can be reversibly inactivated by oxidation.
What are the official names of this protein?
Listeriolysin O, LLO, Thiol-activated cytolysin.
What is the protein family that this protein belongs to?
Belongs to the cholesterol-dependent cytolysin family.
What are the subcellular locations of this protein?
Secreted. Host membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein that then inserts into the host membrane and forms pores formed by transmembrane beta-strands.
Protein: RUVC_CHLPD
Sequence: MVVLGVDPGSLKTGYGVVRQDSSGFSVLTCGVIRLHSGKSHAERIGQIYRELEEIINSTKPRRVALETVFLSKNAQSALKLGQVRGAVIALSMNTDLELHEYAPREVKSAVTGRGSASKEQVAFMVTRMLQVTGHITSYDVTDALGLALCDLLRIGNRAAQEPAQGISRGNKNWTGFVRAFPEMVVR
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: UXAC_CORGL
Sequence: MTTSHASHPDRLLPADPGTRDIARRLLAHVEDLPIISPHGHLEASMFVKDEAFPDPTSLLISPDHYLTRMMHSAGVDLADLRVGGHEGKSAREAWRIFMSHWDLYAGTATGYWVEQEFEHVFGINAERLNVGTPEHADAIFDELTDILAKPDFRPRALAEQFNLEVLATTDDPLDDLADHKALADDPTFSPRVLPTFRPDAYTKMYNAGWAEKTTKLIDTAGDGKAGWEGYLQAMRNRRQYFINHGATSADHGLHDTDTTPLSHKDAQKILDKGLAGTATLAEMHAFEANTTYRFAEMSQEDGLVMTIHPGVYRNHSASAQKKFGADIGADIPFQMEFTNGLRPLLSDFGENKDLISDSSFNRWLRTVSLGSTQDADMAAASNLAANSKMARQNTRDILDAVSDGGVMLGRNGALVLGPVVGTLHIKFIAPLNKRVERVMYKTGLSEAAAAEQCALEDRLREEMAHALYQWNPGRDENYDLVINTGSMTYEQIVDLVVETYARKYPLHVRIIPNGKDQ
What are the official names of this protein?
Uronate isomerase, Glucuronate isomerase, Uronic isomerase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
Protein: MED6_KLULA
Sequence: MSLPPLDELQWKSPEWIQTFGLHTDNVLDYFSESPFFDKTSNNQVVKMQQQFSQQSQVPGSMPLGSSSGIGAAAGAGTVSPSDRSLIWERYPVHAMLEKELMKMKGIEYILVLVREPDLWIIRKQQRDGPTKTTTLRDYYVIGSAVYQSPTVYKIIQNRLLSTNYHLSHSLSQLNKLVEFHPAQGASFLRPEDPLCSSVAAATTSGSTASHTVASSVSVPETGPINAETSGATAAATSIDPDRRQDSFNTEIMDKLMATSIKANPVYI
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 6, Mediator complex subunit 6.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 6 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DER_METCA
Sequence: MLPVVALIGRTNVGKSTLFNYLTRTRDALVADFPGLTRDRQYGRVQRGERDYFVVDTGGIIEAAEGIDDQAMKQVDHVLDEADVILFLVDVHAGMTAGDELIADRLRRINKPVLLVANKIDGTQALIAGAEFHAFGLGEPLLISAAHGTGVHALLERVEALLPESGETGETEAEGGIRIAVVGRPNVGKSTLVNRILGEERVVVYDQPGTTRDSIYIPFERRGERYTLIDTAGIRRRARVNEGVEKFSVIKSFQAIEKAHVVIYLVDASEGLTDQDANLLGMVLEIGRGLLIGFNKWDGLEPEQREKVKRQIDVKLPFLEFAKKYFISALHGTGVGVLMDAVKPIYQSAMLDLSASRLTQVLQDCLTAHPPPLVRGRRIKLKYAHQGGHNPPVVVIHGNQTEDLPAAYRRYLGNEFRNAFKLQGVPLKLVFKSAENPFQGRRNELTERQIRKRRRMIRHVKKR
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: MURB_GEOSL
Sequence: MNDRLAARLEAEVRGEILRDEPMARHTSLRVGGPADFFVTPADPDDMRALLAILAETGTPWLAVGGGYNLLIRDGGFRGVVISSARMTSLERLEGNRAVVGAGVANGRLTAFLRNEGLAGLEFLCGIPGTVGGALAMNAGAHGGAILDRVEEILTIGTAGFECKGRELLDYGYRYLKLQPGEIIIGATFVLDSDDPRRISERIDGCRAHRTASQQVGFPNAGSFFKNPPGQAAWRLIEDAGLRGARVGGAQVSEVHTNFLVNRGGATAADFLALAARIKDAVKLKSGTALEEEVKIFGDE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBIB_MYCLE
Sequence: MTSSDSHRSAPSPEHGTASTIEILPVAGLPEFRPGDDLSAALAAAAPWLRDGDVVVVTSKVVSKCEGRLVPAPEDTRGRNELRRKLINDETIRVLARKGRTLIIENGLGLVQAAAGVDGSNVGRGELALLPVNPDASAAVLRIGLRAMLGVNVAVVITDTMGRAWRNGQTDVAIGAAGLAVLHNYSGAVDRYGNELVVTEIAVADEVAAATDLVKGKLTAMPVAVVRGLSPTDDGSTAQHLLRNGPDDLFWLGTTEALELGRQQAQLLRRSVRQFSDEPIAAELIETAVAEALTAPAPHHTRPVRFVWLQTPAVRTRLLDRMADKWRLDLASDALPADAIAQRVARGQILYDAPEVIIPFMVPDGAHAYPDAARASAEHTMFIVAVGAAVQALLVALAVRGLGSCWIGSTIFADDLVRAELELPADWEPLGAIAIGYAHEPTDLREPVRVADLLLRK
What is the function of this protein?
Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.
What are the official names of this protein?
Bifunctional F420 biosynthesis protein FbiB.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the CofE family.
Protein: BIOD_BRUA1
Sequence: MNSRLIVTGTDTGIGKTVFSAALCHALGAVYWKPVQSGLEEETDSEIVARLAQASPQRILPEAWRLNTPASPHLSARLDGVEIRPEEMHIPATSLPLVIEGAGGLLVPLNDKTLFADLFAIWRIPAILCARAALGTINHTLLSLEAMRSRDIPVLGVAFISEANEDTETTIAHLGRVKRLGRLPLLDDLSPEKLHHSFARNFHIDDFAGVAR
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2744_HALH5
Sequence: MVMATTLFLLAGLAEIGGGYLIWLWLRDGKPVYLGLFGAVALALYGVIATFQAFPSFGRVYAAYGGVFIFLAVLWGWWIDGKAPDTYDWIGAVICLVGVGIMLWAPRP
What are the official names of this protein?
UPF0060 membrane protein BH2744.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
Protein: ATPG_ACEWD
Sequence: MAENVQDIKRRIKSVNSTMQITHAMELVASAKLRKSRELAEGRRPYFEAMIESIGRIVEKSGNARNIFMDQREVKKTAYIIITGDKGLAGGYNVNVAKLVEEHITDKENAVLFTVGSRGRDHFRNREYHIQGEYLGISERPNFFNAKEVTAIVMEGFKNGEYDEVYIAYTKFVSTITQHAQMMKLLPLSAEELITSGKVKTTEETKEEKSKMSDRELTIMTYEPEPEELLKYLIPNFVSSTVYGSMIESAASEQGARRTAMESATTNANEMIDGLTLQYNRVRQAAITQEISEIVGGAEALN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain, sodium ion specific, F-ATPase gamma subunit, sodium ion specific, Na(+)-translocating ATPase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: CILP1_MOUSE
Sequence: MAAIKTWVFSFLVLEVTTVLGRQTMLAQSVRRVQPVKRTPKTLAKPADSQESPGEWTTWFNIDHPGGQGDYERLDAIRFYYGERVCARPLRLEARTTDWMPAGSTGQVVHGSPREGFWCLNREQRPGQNCSNYTVRFLCPPGSLRGDAEHIWSSWSPWSKCSAACGHTGVQTRTRTCLAQTVSLCSEATEEGQLCMSQACTACDLTCPMGQVNADCDACMCQDFMLHGAISLPGGGPAPGAAVYLLAKAPKMLTRTDSSGRFRVPGLCPDGKTILKITKTKFAPIMITMPKTSLKSATINAEFVRAETPYIVMNPEMKARRAGQSVSLCCKATGKPSPDKYFWYHNNTLLDPSLYKHESKLVLRNLQQDQAGEYFCKAQSDAGAVKSKVTQLTVIAHDETPCNPTPESYLIRLPHDCFQNASNSFYYDVGRCPIKTCAGQQDNGIRCRDAVENCCGISRTEEREIQCSGYTLPTKVAVECSCQRCAETRSIVRGRVTATDNGEPMRFGHVYMGNNRVSMTGYKGTFTLHIPQDTERLVLTFVDRLQKFVNTTKVLPFNKKGSAVFHEIKMLRQKEPITLEAMETNIIPLGEVIGEDPVAELEIPSKSFYRQNGEPFTGKVKASVTFLDPRNISTATAAQSDLNFINDEGDTFPLRTYGMFSVDFRDEATSESLNAGKVKVHLDSTQVKMPEHVPAMKLWSLNPDTGLWEEEGDFKFESQRRNKREERTFLVGNMEIRERRLFNLDVPESRRCFIKVRTYRSERFLPSEQIQGVVVSVINLEPRTGFSSNPRAWGRFDSVITGPNGACLPAFCDDQSPDAYSVYVLASLSGEELEAVESSPKFNPNAIGVPQPYLNKLKYRRTDHEDPRVKKTAFQISMAKPRPNSAEESNGPIYAFENLRACEEAPPSAAHFRFYQIEGDRYDYNTVPFNEDDPMSWTEDYLAWWPKPMEFRACYIKVKIVGPLEVNVRSRNMGGTHRQTVGKLYGIRDVKSTRDRDQPNVSSACLEFKCSGMLYDQDRVDRTLVKVIPQGSCHRASVNSMLHEYLVNHLPLAVNNDTSEYTMLAPLDPLGHNYGIYTVTDQDPRTAKEIALGRCFDGTSDGSSRIMKSNVGVALTFNCAERQVGRQSAFQYLQSTPARSPATGTVQGRVPAMRQQRASRGGLRRRGSMAPLRFSGVAQQPLSN
What is the function of this protein?
Probably plays a role in cartilage scaffolding.  May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions.  Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation.  May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1.  Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity).
What are the official names of this protein?
Cartilage intermediate layer protein 1, CILP-1.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.