PharMolix/UniProtQA huggingface dataset:
Protein: NUOCD_CHRSD
Sequence: MSAAQSPTAQHAHAEDPVVQALFARFGQHVFVAQATHTGMPVLWLDREYLLEVLNFLRDMPEPFEMLFDLHGIDERLRSHREDLPPADFTVFYQLMSISRNRDIMLKVALSERDLEVPSVAGVYPNANWYEREVWDMFGIDFRGHPHLTRLLMPPTWNGHPLRKDYPARATEFDPYTLTVEGQSTEQEALRFDPEAWGMQRQSENTDYMFLNLGPNHPSAHGAFRIALQLDGEVVVDCVPDIGYHHRGAEKMAERQSWHSYIPYTDRIDYTGGVMNNLPYVMAVEKLAGIEVTDRAKTIRVMMAEMFRINSHLLFLGTYLQDLGAMTPVFFTFTDRQKAYEVIEGITGFRMHPAWYRIGGTAHDLPRGWDKLVQGFLDWMPKRLVEYERAMMENAIIRERTKQVAAFTTREALEWGVTGPNLRATGCDFDLRKQRPYSGYENFDFEVPLGANGDVFDRGQLRIDEMRQSLRIIQQCVDHMPAGDYKADHPLTTPPPREKMLQHIETLITHFLQVSWGPVLKPNESLSMIEATKGINSYYLTADGNTMSYRTRIRTPSFPHLQQIPAAVRGALVPDLIAHLGSIDFVMADVDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C/D, NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: NUOI_ROSDO
Sequence: MTQVDYTRAAKYFLLQDFWVGMKLGMKYFFAPKATLNYPHEKGPLSPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIDAEPRDDGSRRTTRYDIDMTKCIYCGFCEEACPVDAIVEGPNFEFSTETREELYYDKDRLLANGERWEAEIARNLEMDAPYR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit I, NADH dehydrogenase I subunit I, NDH-1 subunit I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ZNUA_BACSU
Sequence: MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFYPMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPSAEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEVKNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYLAKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEIGAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS
What is the function of this protein?
Part of the high-affinity ABC transporter complex ZnuABC involved in zinc import (Probable).  ZnuABC-mediated zinc transport is required for comF expression and competence development.
What are the official names of this protein?
High-affinity zinc uptake system binding-protein ZnuA.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 9 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Membrane raft; Lipid-anchor. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.
Protein: VES_ECOUT
Sequence: MEYFDMRKMSVNLWRNAAGETREICTFPPAKRDFYWRASITSIAANGEFSLFPGMERIVTLLEGGEMFLESADRFNHTLKPLQPFSFAADLVVKAKLTAGQMSMDFNIMTRLDVCKAKVRIAERTFTTFGSRGGVVFVINGAWQLGDKLLTTDQGACWFDGRHTLRLLQPQGKLLFSEINWLAGHSPDQVQ
What are the official names of this protein?
Protein Ves.
What is the protein family that this protein belongs to?
Belongs to the Ves family.
Protein: Y1043_BACC7
Sequence: MTKNIHDVAYELQKAIAENDDFKTLKESYAAVQADAASKNLFDEFRTMQLSLQQKMMQGQEITEEDNQQAQEVVVRIQQDAKITKLMETEQRLNVVIGDVNKIIMKPLEELYSAQQQA
What are the official names of this protein?
UPF0342 protein BCAH187_A1043.
What is the protein family that this protein belongs to?
Belongs to the UPF0342 family.
Protein: Y2141_STRE4
Sequence: MLTFLIPTAKEMKPVPPCYPHQLPQKSLPILEAMAELSLEELARAYSIRIEAASKEAKRLKAIAQGQSSAYPAYQLFNGLMYRHLKRDNLSKDQQDYLSKQVYITSSFYGIIPTDEKIAEHRHDFHTKVTINGQSLKHYWRPIYDQFAKDHKQIISLLSNEFRDVFSKEYQKLWISPKFMEERSGQLKTHSTISKKARGAFLTACLENNVQTKEALKQLSFAGFCYNEELSTETNYYYIKKES
What are the official names of this protein?
UPF0246 protein SEQ_2141.
What is the protein family that this protein belongs to?
Belongs to the UPF0246 family.
Protein: AMPA_BRUA4
Sequence: MSKRPSISFSDFAAPEKGVSIVLVAKGGGFADEAAQAAGGAEKIKRIAEISGFTGALGKTAEAIETTSSGVDKIVLVGVGEPGKLGNDDWLKIGGAAFSRIGKAERATVTLALPETTIAGDEAADLALGMILRSYKFERYKTRKNNEENGDPKHAAKISICVADPHTAKRAFEVAEAVADGVIQARNLVNEPANILGPVEFAQEAEKLEKLGVKIEVLGEKEMKKLGMGALLGVAQGSVRPPRLVIMEWQGAKSKEKPVAFVGKGVVFDTGGISIKPAAGMEDMKGDMGGAAAVTGLMRALAGRKAKVNAIGIIGLVENMPDGNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALHYTNDRFKPRFIINLATLTGAVMVALGQYHAGLFSNDDELADQLYDAGQLTGEKLWRLPLGTEYDKMIDSKFADMKNSAGRYGGSITAAQFLKRFVGETAWAHLDVAGTAMGSPANEYSQTWASGYGVRLLDRLVRDHFES
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UGPA_SALTI
Sequence: MSSSRPVFRSRWLPYLLVAPQLVITVIFFIWPAGEALWYSLQSVDPFGFSSQFVGLENFVALFHDSYYLDAFWTTIKFSALVTFSGLLVSLFFAALVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLGEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFRLSLPLIAPVSFFLLVVNLVYAFFDTFPVIDAATAGGPVQATTTLIYKIYCEGFTGLDLSASAAQSVVLMFLVIILTVVQFRYVESKVRYQ
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Probably responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
sn-glycerol-3-phosphate transport system permease protein UgpA.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SUV91_PONAB
Sequence: MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
What is the function of this protein?
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate.  H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones.  Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.  H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.  SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length.  Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes.  The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.  Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity).
What are the official names of this protein?
Histone-lysine N-methyltransferase SUV39H1, Suppressor of variegation 3-9 homolog 1, Su(var)3-9 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus lamina. Nucleus, nucleoplasm. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Protein: RF1_HYDCU
Sequence: MKESIRSKLENLVERLDEVNHLISDPEIINNQNKFRNLTKEHSQLTPVVETFNQFIQNQGDLQEAKDMIKSGDPDLKEMGQEELPELEKQQATLEAELQKMLLPKDPNDDANIFLEIRAGTGGDEAAIFAGDLFRMYSRYAETMRWQVEVINSQEGEHGGYKEIIARIIGDGAYSRLKFESGAHRVQRVPATETQGRVHTSAATVVIMPEAQDVEQIDLNPADLKVDTFRASGAGGQHVNKTDSAIRITHIPTGTVVECQDERSQHKNRARAMSLLASRIMDERQRIHDQEIAQERKSLVGSGDRSERIRTYNYPQGRVTDHRINLTLYKLDEIMQGGLQQVVDPLINEYQAEQLAALSEDSA
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DBP8_ASPNC
Sequence: MAPSSSPEPVVDESHESSDSEVEQTELQSRAPKRRRLSESSTDSYVAPAPLPTLSRIKKKGADEENKPATSDKDEPVLIKDALEIGLNDAQNSFASLNVAPWLIGSLTTMAVRKPTAIQKACIPEILNGRDCIGGSRTGSGKTIAFSVPMLQKWAEDPFGIFGLVLTPTRELALQIYEQIKAISAPQSMKPLLITGGTDMRPQAVALAQRPHVVIATPGRLADHINTSGSDTIRGLKRVRMVVLDEADRLLAPGHGSMLPDVETCLSALPPSSERQTLLFTATLTPEVRALKSMPRPSTKPPIFVTEISTENNASIPPTLKQTYLKVPMTHREAFLHVLLSTEANASKPAIIFCNHTKTADLLERMLRRLSHRVTSLHSLLPQSERNANLARFRASAARLLVATDVASRGLDIPSVELVVNFDVPRNPDDYVHRVGRTARAGRKGESVTLVGQRDVSLVLAIEERVGRQMEEWSEEGVSVEGRVVRTGVLKEVGEAKREAAGEIEEGRDVLGRKRNKLKKVR
What is the function of this protein?
ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites.  Required for vegetative growth (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase dbp8.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: METN_THEFY
Sequence: MINAVDLHKVYQLKGREVVALRGVSLHVPQGEIYGVVGPSGAGKSTLLRCINLLERPDRGEIWVDGRNLTALPPPQLRAARRGIGMIHQHFALLSSRTVAGNVAFPLEIAGVPRAERRRRVAELLELVGLADKAAAYPAQLSGGQKQRVGIARALAPRPTVLLSDEATSALDPATTASILDLLRDLNRELGLTILLITHEMDVVKRICDAVAIMDRGSVVETGRTVDLLRTPGSLLARSLFAPPPVSGDGVVTLTWVDQAEEPLISQLTRLFDVDVSILGGALEEVAGHAVGRLTVRITGERSAEALTYLTDRNVLVEEVP
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: AQP1_LACBS
Sequence: MHPQVASLFDNVYEDLAAATLEFIGTAFFLLFGLGGIQASTAEDTASGQPPASGIEHVLYISTCMGLSLVVSAWLFFRVTGGLFNPNISFALLLVGGLKPLRFVLFCIAQLTGAIAGAAIVRGLTSAPLSVNNVLQQGTSAAQGVFIEMFITAALVLSVLMLAAEKHEATPFAPVGIGLTLFACHLFAVYYTGAAMNSARAFGPAVISGFPEPQHWVYWVGPFLGSLLGAGFYATLKHYKYWHLNPDQATSDYRKSPSDPVALLKSTAETFINVGDEETRNGCASNEEGVRATGDEKSSNATSSRTNFSPV
What is the function of this protein?
Water channel required to facilitate the transport of water across membranes (PubMed:21352231).  Enables also low but statistically significant ammonium permeability (PubMed:21352231).  May be involved in fungal nitrogen (ammonium) support of the plant host in symbiosis (PubMed:21352231).
What are the official names of this protein?
Aquaporin Lacbi1:392091.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein: THIC_NITWN
Sequence: MNIRSNPDTTRPAVTTGALPSSRKMFSAPDAAPDLRVPLREILLSEGAGEPNLPVYDTSGPYTDPNVIIDVNAGLPRTRLAWVKERGGVEEYDGREIKPEDNGNVGASHAAAAFKAHHKPLRGIGDAPITQLEFARAGIITKEMIYVAERENLGRKKQLERAEAALADGEAFGASVPAFITPEFVREEIARGRAIIPSNINHAELEPMIIGRNFLVKINANIGNSAVTSSVEEEVDKMVWAIRWGADTVMDLSTGRNIHTTREWILRNSPVPIGTVPIYQALEKCDGDPVKLTWELYRDTLVEQCEQGVDYFTIHAGVRLPYIHLTADRVTGIVSRGGSIMAKWCLAHHKESFLYTHFEEICDLMRKYDVSFSLGDGLRPGSIADANDRAQFAELETLGELTQIAWKKGCQVMIEGPGHVPMHKIKINMDKQLKECGEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPNRDDVKTGVITYKIAAHAADLAKGHPAAQLRDDALSRARFDFRWQDQFNLGLDPDTAVAFHDETLPKDAHKVAHFCSMCGPKFCSMKITQDVRDYAATLGDNEKAALYPDTAPKANDAAGVPEPSYRDQGMKEMSARFKEMGGNVYLDAEKVKESNRVL
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: RNPA_SALPK
Sequence: MVKLAFSRELRLLTPAHFTFVFQQPQRAGTPQITILGRLNSLGHPRIGLTVAKKNVRRAHERNRIKRLTRESFRLRQHELPAMDFVVVAKKGVADLDNRALSEALEKLWRRHCRLARGS
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: 3L21_DENVI
Sequence: RTCYKTPSVKPETCPHGENICYTETWCDAWCSQRGKREELGCAATCPKVKAGVGIKCCSTDNCDPFPVKNPR
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Alpha-elapitoxin-Dv2b, Alpha-EPTX-Dv2b, Long neurotoxin 1, Neurotoxin 4.7.3/4.9.3.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: TPIS_SHIBS
Sequence: MRHPLVMGNWKLNGSRHMVHELVSNLRKELAGVAGCAVAIAPPEMYIDMAKREAEGSHIMLGAQNVDLNLSGAFTGETSAAMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLKEQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKVDANIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGASLKADAFAVIVKAAEAAKQA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPO12_SULIY
Sequence: MAVYRCGKCWKTFTDEQLKVLPGVRCPYCGYKIIFMVRKPTIKIVKAI
What is the function of this protein?
DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit Rpo12, DNA-directed RNA polymerase subunit P.
What is the protein family that this protein belongs to?
Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2RX7_HUMAN
Sequence: MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
What is the function of this protein?
Receptor for ATP that acts as a ligand-gated ion channel.  Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules.  Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.  In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).
What are the official names of this protein?
P2X purinoceptor 7, P2X7, ATP receptor, P2Z receptor, Purinergic receptor.
What is the protein family that this protein belongs to?
Belongs to the P2X receptor family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATP6_SPIOL
Sequence: SPLEQFSILMLIPM
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RAPA_PSEAE
Sequence: MDMAQYQPGQRWISDSEAELGLGTILAQDGRLLTVLYPATGDTRQYALRNAPLTRVRFAPGDEVTHFEGWKMTVREVEESEGLLVYHGLTAQNEQRTLPETQLSNFIQFRLASDRLFAGQIDPLPWFSLRYHTLERRSQLLQSSLWGLGGARAQPIAHQLHIAREVADRMAPRVLLADEVGLGKTIEAGLIIHRQLLSGRAGRVLILVPENLQHQWLVEMRRRFNLQVALFDKERFAESDASNPFEDTQLALVALEWLKEDERAQDALFAAGWDLLVVDEAHHLVWHQDQVSAEYALVEQLAEIIPGVLLLTATPEQLGQDSHFARLRLLDPNRFHDLEAFRRESEQYRPVAEAVQELLDHGSLSAGARKAIHGFLGSEGDELLASVEGGDEEARSRLVRELLDRHGTGRVLFRNTRAAVQGFPQRELHAYPLPMPSQYEELPAGEHPDLYPEVNFQQQWEDGDDNNRWWRFDPRVEWLIDTLKMLKQFKVLVICAHAETALDLEDALRLRSGISATVFHEGMSILERDRAAAYFADEEFGAQVLICSEIGSEGRNFQFAHHLVLFDLPAHPDLLEQRIGRLDRIGQRHTIQLHVPHLENSAQQRLFQWYHQALNAFLNTCPTGNALQHEFGPRLLPLLDGGEDKAWDALLAEGRARREALEAELHSGRDRLLELNSGGAGEGEALVEAIEEQDDDFALPIYMERLFDAYGIHSEDHSENALILKPSEKMLDAGFPLGDDEGVTITYDRAQALAREDMQFLTWEHPMVQGGMDLVLSGSMGNTSVALIKNKALKPGTVLLELLFVSEAVAPRALQLGRWLPPQALRCLLDANGNDLAGRVSLETLNDQLESVPRVSANKFVQAQRDVLAKQFDVAEGKIVPRHEERVARAKQQFAAAMDEELARLTALKAVNPSVRDSELDSLRTQREEGLALLDKASLRLEAIRILVAG
What is the function of this protein?
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations.  Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA.  Does not activate transcription on linear DNA.  Probably not involved in DNA repair.
What are the official names of this protein?
RNA polymerase-associated protein RapA, ATP-dependent helicase HepA.
What is the protein family that this protein belongs to?
Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
Protein: U2_TIBVC
Sequence: MATQAHLLVSYYYDISSEGVPGVPINTICHGLEFDYMGNNTTDDLEKVFLGSILRADLRGSGYYSYIRLVNEGKICLKIAFDQSLNWTLSGEKEFKSDFRVGSGTISVTFKCYWLRVSEKIWKGSLYKFDTTKNPQVLVYRLLEPKKQR
What are the official names of this protein?
Protein U2.
What is the protein family that this protein belongs to?
Belongs to the tibrovirus protein U2 family.
Protein: T161A_MOUSE
Sequence: MAVLGVQLVVTLFTATLMHRLAPHCSFARWLLCNGSLFRYIHPSEEELRALSGKLRPRVRKERWANGLHDEKPLSVPRDAHFQLQTCPLTAVDALVLRFFLEYQWFVDFAVYSVGVYLFTEAYYFVLGPVQETNIAVFWCLLTLAFSLKVFLMVTRLYFSTKEGGERSVCLSFAFLFLLLAMLVQVVREETLELGLEPGLASMTQHLEPILKKQDWDWTLPVIKLAIRLGLAVLGSLLGAFLIFPGLRLAQTHQDALTLSADRPLLQLLLHTSFLSPLCTLWLWTKPVARDFLYQAPTRNMTFSVPSEGAFDSLRLWVLVALCLLRLAVTRPHLQAYLCLAKARVEQLRKEAGRIEAREIQQRVVRVYCYVTVVSLQYLTPLILTLHCTLLLKTLGGYSWALSSTPPPLAPSQPSEALIPVDPAGDEAQQTAAQVAGILGGLLTPLFLRGMLAYIIWWTAACQLLSSLFGLYFHQHLAAS
What is the function of this protein?
May play a role in protection against oxidative stress.  Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis (By similarity).
What are the official names of this protein?
Transmembrane protein 161A.
What is the protein family that this protein belongs to?
Belongs to the TMEM161 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TRPD_GEODF
Sequence: MIKKAIARVVEREDLSQSEMIQVMDQIMSGEATPAQIAAFITALRMKGETVAEIAGAARVMRDRATRIRVGKNVLDLDRDDINIDLETILDVVGTGGDGTNTFNISTTVSFVVAACGVKVAKHGNRSVSSACGSADVVEALGISLEVTPETVENCINEAGIGFLYAPALHGAMKFAIGPRKEIGIRTIFNILGPLTNPAGAPCQVLGVYREELVEKLAHVLKNLGCRRGFVVYGMDGMDEITLTTETRMAEVTPEEVKAWLFKPEDLGFARCTMDDLRGGDAVANAVTVRGILEGEKGPKRDVVLINAAFGLVAAGRAANPAEGVKLAVEALDSGAALAKLEKLKALTNA
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: FPPS_MYCTU
Sequence: MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA
What is the function of this protein?
Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP).  May be used for squalene and possibly sterol biosynthesis.
What are the official names of this protein?
(2E,6E)-farnesyl diphosphate synthase, E,E-FPP synthase, FPP synthase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.