PharMolix/UniProtQA huggingface dataset:
Protein: RL10_EHRCJ
Sequence: MKRSDKELHLSKVEGLFSKFKYFIIANFQGMVANDFFSLRKELKMANSGLMVVKNSLSRIALKKMGREELSAKFFGSIFIVYSDDIILISKILAKFMKDNKSKISLLCAYDSNEILDSEKVLYFASLPSLRELHAQIMSMISYNIPVRLALCLKALGNKE
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: COX2_PERAM
Sequence: MTTWANMNLQDSASPIMEQLIYFHDHALMIIIMILMVVSYMMIAMVFNKYINRFLLEGQMIELAWTIAPAVILIFIAVPSLRLLYLMDEINTPTVTLKTIGHQWYWSYEYSDFAKVEFDSYMIPQDEMDHSMFRLLDVDNRAVLPMNTFIRIIVTAADVLHSWTIPSLGVKADATPGRLNQVSFLINRPGVLYGQCSEICGANHSFMPIVIESISTNGFINWILKMNM
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MOAC_OLEA2
Sequence: MSSGFSHMDGDGSITMVDVGDKKDTRRTAIVRGKVEMAPATLDMLVKQALPKGDVLTTAKVAGIQAAKRTWELIPLCHPLFLSYVDVRFTVDESLPGVVVEAEARTTGQTGVEMEALVAAQVAAMTIYDMCKAVQKDIVLRDCRLVYKSGGKSGEFRAC
What is the function of this protein?
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
What are the official names of this protein?
Cyclic pyranopterin monophosphate synthase, Molybdenum cofactor biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the MoaC family.
Protein: AROB_CHLTR
Sequence: MIELVTDSPHPIHLVDSLQNPKLFASLSTDFPLIFITNTKLNALILPPLLDLARSLGFSVETLTIPEGEETKTGDTFLSLHQQLTDLNVPRQATLIGVGGGVILDIAGFVAATHCRGMPFIAIPTTLVAMIDASIGGKNGINLNHIKNRIGSFYLPKAVWICPRKLSFLPQQELHHGIAECIKHAYIADSAILPLLQDPNALKKEDKLSLLIKKNCLCKASVVQQDVRDYAKRQILNFGHTLGHALEMLFIGKIPHSCAISVGMVLETKLSLSLGVARSPAILHSLIQDLLRYQLPVSLKDLYMRAQIPPHNCDQILSALTYDKKKQNTPLPPFVMIEEIGLAASFDGRFCQTISKHILTKVLEEEFYAMHNN
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHO88_YEAST
Sequence: MNPQVSNIIIMLVMMQLSRRIDMEDPTIIMYIRILYCSSIGISWIIYQMARKRIVAKNDMTTMKYVEPGNAMSGEGEKLQVTTVRDYDLKEIDSAIKSIYTGMAMMGFMHLYLKYTNPLFMQSISPVKSALEHNEVKIHLFGKPATGDLKRPFKAPSLFGGMGQTGPKTDKKSIEEAERAGNAGVKAE
What is the function of this protein?
Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum.  SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs (PubMed:27905431).  Involved in inorganic phosphate uptake (PubMed:8709965).  Also involved in telomere length regulation and maintenance (PubMed:16552446).
What are the official names of this protein?
SRP-independent targeting protein 3, Inorganic phosphate transport protein PHO88, Phosphate metabolism protein PHO88.
What is the protein family that this protein belongs to?
Belongs to the PHO88 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion.
Protein: CDN1A_FELCA
Sequence: MSEPSRDAHQIPHGSKACRRLFGPVDSEQLRRDCDALMAGCVQEARERWNFDFVTETPLEGDFAWERVWGLGLPKLYLPAGPRGGRDDLGGGKRPSTSSTLLPGTAREDHLDLSLSCTLMPHSPERPEASPGAPGTSQGRKRRQTSMTDFYHSKRRLIFSKRKP
What is the function of this protein?
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity).  Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity).  Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity).  At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).  Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity).  Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, p21.
What is the protein family that this protein belongs to?
Belongs to the CDI family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SCYL1_HUMAN
Sequence: MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAKGPMKLGARKLD
What is the function of this protein?
Isoform 6 acts as transcriptional activator.  It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region.  It also binds to the TERT promoter region.
What are the official names of this protein?
N-terminal kinase-like protein, Coated vesicle-associated kinase of 90 kDa, SCY1-like protein 1, Telomerase regulation-associated protein, Telomerase transcriptional element-interacting factor, Teratoma-associated tyrosine kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis- Golgi in an ARF1-independent manner. SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle. SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle. SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner. SUBCELLULAR LOCATION: [Isoform 6]: Nucleus.
Protein: PEPVL_STAES
Sequence: MWKEKVLEYENQMIEDLKGLLSIESIRDDSKATADAPVGPGPREALDYMYNLGKRDGFSTHDVDHIAGRIEAGKGEDVLGILCHVDVVPAGDGWDSNPFQPVVTDNAIIARGTLDDKGPTIAAYYAVKILNEMKVDWKKRIHIIIGTDEESDWKCTDRYFKTEEMPALGFAPDAEFPAIHGEKGITTFDLVQNEVTEDTDEPDYELLKFESGQRYNMVPDYAKAEVLVKENMTDVIQNFENFLQQNQLQGESTVDSGILILTIEGKAVHGMDPSLGVNAGLFLLKFLASLNLNKSAKDFVEFNERYLFESHFGEKMGMKFHTDIMGDVTTNIGVISYDKEKAGRYGINLRYPEGFKFEDAIDRFRSEINELGFNLELGKVQKPHYVDKNDPFVKTLVNAYRNQTGDMTEPYTIGGGTYARNLDKGVAFGAMFADSEDLMHQKNEYITKKQLINATSIYLEAIYALCVED
What are the official names of this protein?
Putative dipeptidase SE_1424.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family.
Protein: VATA3_METHJ
Sequence: MGEKNGVIIRVTGPVVEAEGMAGSRMYESVRVGNDGLIGEIIILEGDRATIQVYEETIGLTPGEPVVRTYLPLSVELGPGLIGTMYDGIQRPLEEILKNTGDMIERGSSAPALDRTKKYRFYPLAKSGDMVREGDRIGCVRESVSVNHYILIPPGLSGTIHFIAEQGEYVITDTIVILDTGEEKKELTMIQRWPVRDPRPVRERLDPVEPLLTGQRIIDTLFPLARGGTAAIPGPFGSGKTVVQQQLAKWVNADIIIYIGCGERGNEMADVLEQFPTLKDPRTGHALSSRMVLIANTSNMPVAAREASVYTGITIAEYYRDMGYHVALMADSTSRWAEAMREISGRLEEMPGEEGYPAYLSSRLADFYERAGRVSLLGSGDHEGSISVIGAVSPPGGDFSEPVTQNTLRIVKVFWALDADLAYQRHFPAINWLMSYSLYSPIAGIWWEEHIGPEFIRMKQEMMEILQRENELEEIIRLVGPETLPESDRLLLLKAEILRESYLMQYAFDEFDTFTGPKKQYRMLKAIFTFFSQAERALETGISVSRLRGLPVIESFARMGTASPEEEDPLFESIARDTDAIRDLKEVL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain 3, V-ATPase subunit A 3.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: PURA_NATPD
Sequence: MTVTIVGSQLGDEGKGGIVDVYGDAVDVVVRYQGGDNAGHTVVHEGDEYKLSLVPSGAVRGKVGVLGNGCVVNPETLFEELDALRERGLTPDVRVAERAHAILPYHRVLDGIEEDVKSDDDLAAGTTGRGIGPTYEDKAGRRGVRIGDLLDAETLRARLEYVVPQKRALVEDVYNLEIGDDIDADAFDVEALFEQYREFGRRLDEEGMTVNCGEFLNEHLDNGDEIMFEGAQGTSIDIDHGIYPYVTSSNPTAGAAAVGTGVGPTVVGRGEVVGIVKAYLSRVGTGPLPTELGSVDGQTPNNGGRPDESDLATYIRDEGGEYGTVTGRPRRVGWLDMPMLRHAARANGFTGLAVNHLDVLAGLEEVKVGHAYTLDGEQLLTMPATTEQWADCEAEFRSFDGWPDVDWGAVADEGYEALPENARTYLDYIADELDAPIYAVGVGPGREETVVVESPL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTPD_ACTFR
Sequence: SVAVAGAVIKGAALTFNILQ
What is the function of this protein?
Pore-forming toxin (PFT) that consists of a crown-shaped octamer or nonamer that forms cation-selective hydrophilic pores of about 1. 5 nm (inside) and 13 nm (outside) and causes cytolysis (By similarity).  It causes cardiac stimulation (By similarity).  Also causes hemolysis (HC(50)=0. 4 nM) (PubMed:31295915).  Interestingly, the Phe-16 is crucial for hemolysis (By similarity).  Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers (By similarity).  It is probable that a dimeric form is an assembly intermediate before the complete oligomerization (By similarity).  The formation of stable pores occurs only in vesicles composed of DOPC/SM (there is no oligomerization when the PFT is treated with vesicles of DOPC or SM alone) (By similarity).  The transmembrane pore displays 8 lateral perforations, one at each subunit-subunit interface, partially occupied by the acyl-chain region of a bridging lipid (By similarity).  Each pore contains 24 lipid molecules, firmly bound to each subunit, that is, 3 lipids (L1, L2, L3, L4 and/or L5) are associated to each subunit (By similarity).  Lipid L1 bridges 2 subunits, whereas lipids L2 and L3 bind to sites at single subunit (By similarity).
What are the official names of this protein?
DELTA-actitoxin-Afr1d, DELTA-AITX-Afr1d, Alpha-helical pore-forming toxin, PFT, Cytolysin, Fragaceatoxin D, fraD.
What is the protein family that this protein belongs to?
Belongs to the actinoporin family. Sea anemone subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst. Target cell membrane. Note=Forms an alpha-helical membrane channel in the prey.
Protein: IF4A_EMENI
Sequence: MASNDKGLEEIPDSQIESNYDEITDSFDSMELKPELLRGVYAYGFERPSAIQQRAILPIVKGNDVIAQAQSGTGKTATFSISALQKLDPNVKACQALIVAPTRELAQQIQKVVIAIGDFMNIQCHACIGGTAVRDDMNALREGPQIVVGTPGRIHDMIQRRVLKTDQMKMFILDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKQELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMEQAQRDVIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase eIF4A, Eukaryotic initiation factor 4A, eIF-4A, Translation initiation factor 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_ACIC5
Sequence: MPKMKTHRGAAKRFKKTGTGKIKRGQSKMRHILTSKETKTKRKLTASAYVSDADHAKVARMIPYA
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: FUCM_SHIDS
Sequence: MLKTISPLISPELLKVLAEMGHGDEIIFSDAHFPAHSMGPQVIRADGLLVSDLLQAIIPLFELDSYAPPLVMMAAVEGDTLDPEVERRYRNALSLQAPCPDIIRINRFAFYERAQKAFAIVITGERAKYGNILLKKGVTP
What is the function of this protein?
Involved in the anomeric conversion of L-fucose.
What are the official names of this protein?
L-fucose mutarotase, Fucose 1-epimerase, Type-2 mutarotase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. FucU mutarotase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NOEB_RHIME
Sequence: MKRIVLLLSPLVILLSPIIDAFQGVYIDPRSDAGYAVIACVAIIGLALGMIATFCYKRGAVGNVVTAGTLAVTLFLFGDLSYGVFWRLADHIGMEGAAALAFAGLVVLILILFKLMAAVPRMMAAFAVALLGSTVLDRGLITEASAEEPAPAVIYIVTDEMIGISGIDTRLPHGAEAKAALSRVFQKHGFRLHSKAFSRHILTQVSVPAALNMDYSYNFPGDRSHYAYPGEVTKFKVLSLFNLWHRQGLSVNVFQSAHLDFCKTEALVDCHTFASFDGSRFIQRQRTEGGPYRDVPPASASLADVKALVEGNRQSLAMAAVGFVASNLLETKETALQEWHPRSYDQLAFPYWLGQFQNMILDKGRGNAFFAHFLFPHSPSVYNKDCKPTNRWVERSYLTEVRGLAGQELDEARVKEYGFYFAQTLCLAKQLDKFFNAVLSDKRFQDATIVVHGDHGSRISAGRNVETMSPRDYVDNYSALYAVRKPGVATGTDYKLHSVQWLNASLFRGNVSEVAPTVVGSIQGKSDDPAVYAPITDPDHVAIMPMHDFDASH
What is the function of this protein?
Not known; does not seem to participate in nod factor synthesis but required for nodulation on some specific Medicago species such as M. littoralis.
What are the official names of this protein?
Nodulation protein NoeB.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CITD_LACAC
Sequence: MEIKTTAVAGTLESSDIQIMISKGSDGIKIDLESEVKKAYGDQIEKVITETLKKYGLDNVNIKATDKGALDCVIKARTLAAAQRATETQDKPDLEVL
What is the function of this protein?
Covalent carrier of the coenzyme of citrate lyase.
What are the official names of this protein?
Citrate lyase acyl carrier protein, Citrate lyase gamma chain.
What is the protein family that this protein belongs to?
Belongs to the CitD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P23D2_HUMAN
Sequence: MYGYRRLRSPRDSQTEPQNDNEGETSLATTQMNPPKRRQVEQGPSTGAKKPSISGAPHLNSYQSLELPQNQQDSGTEELMIVLEQGTEVRLSLEEVILILAPETVLQLTLENTVLVIVPEHVLRSEDGLQSPVQIQYIIPSVDDFSLEFHAQDGDISDMRRENVPFSPAEEGKAAPLYQQPLMIPQANHMAGISPSFLVTPLCIPRCRAAFPQCYPLPPTPSPVGRPRPADSSFSLHGMELLCTSSLRPMPPSPSPGPQVYHRVHHRPPSRARRCLFRK
What are the official names of this protein?
Proline-rich protein 23D2.
What is the protein family that this protein belongs to?
Belongs to the PRR23 family.
Protein: IF5A_METKA
Sequence: MDVAVKKVEVRQLKKGKYIMIDDEPCKIVEYTTSSPGKHGSAKARIVAVGLFDGKKRTLTKPVDAKVDVPVIERKTAQVVSDMGDTVQLMDMETYETFEVQKPEDEELASQLEPGTMVEYMEAAGKRKIVGIKEEE
What is the function of this protein?
Functions by promoting the formation of the first peptide bond.
What are the official names of this protein?
Translation initiation factor 5A, Hypusine-containing protein, eIF-5A.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL22_HAEDU
Sequence: METIAKHRYARTSAQKARLVADLIRGKKVAQALEILTFTNKKASALVKKVLESAIANAEHNDGADVDDLKVAKIFVDEGPSMKRVMPRAKGRADRILKRTSHITVVVSDR
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RMF_ECOLI
Sequence: MKRQKRDRLERAHQRGYQAGIAGRSKEMCPYQTLNQRSQWLGGWREAMADRVVMA
What is the function of this protein?
During stationary phase, converts 70S ribosomes to an immature dimeric form (90S ribosomes) which are converted to inactive 100S ribosomes (a process called ribosomal hibernation) by the hibernation promoting factor HPF (PubMed:7677746, PubMed:18174192).  Inactivates ribosomes by covering the peptidyl transferase (PTase) center of the 23S rRNA and the entrance of peptide exit tunnel (PubMed:12473202, PubMed:15066119).  However crystallization with T. thermophilus 70S ribosomes shows it binds near the 3'-end of the 16S rRNA near the anti-Shine-Dalgarno sequence, where it would sterically hinder translation inititation (PubMed:22605777).  In this crystal binding of RMF induces movement of the 30S head domain away from the rest of the ribosome, presumably so they would more easily form dimers (PubMed:22605777).  Also involved in protection against heat stress, but this role is not dependent on the maintenance of ribosome dimers (PubMed:15278243).
What are the official names of this protein?
Ribosome modulation factor, RMF, Hibernation factor RMF, Protein E.
What is the protein family that this protein belongs to?
Belongs to the ribosome modulation factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECDB_LYMDI
Sequence: SELTVEDVEPLNNADKNKVVIXI
What is the function of this protein?
Stimulates synthesis of ecdysteroid in the testes of larvae and pupae.
What are the official names of this protein?
Testis ecdysiotropin peptide B, TE.
Protein: RECO_LEPBA
Sequence: MAIRKEIGIIIQSKDIGESDRLISLAGETQVRMNFISKGIRKSKRRAIISTELGCLVEVDYYDQVEKDWKSTKEIHLIKRYDELKKDYVGTLFVLYLTELTSQLYPDGENHPFLYQLLSGSLEVSNENGFRKEILPFFKLRALTHMGHFPTEFYCHTCGEEVLTKAKAYFSVDSREFLCSDCHPITKDHLPVLKLFHTMLSKKFSNVLVIFPKEAEYREGDMILNQFLRSLLGRELKSYFEFYKTIGDL
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: RNY_MYCMS
Sequence: MNDDIIILLSVFCGIFFICFIICSSIALYLWKSKSRKRLVEQYTKEAKQAKKQILANGYKEISEAKMLFLKRSELEKNELDRVKEQLELRSNDLKRNQEIVESKSQRLDASLLDLEKRKFLLDKKEEYLIKILEDASGLTKSQAKELLIKQVKNKSEKELISILKNAELQAHSSSKMIANNIIISAMERIKVELTSQRTTNIVKLPSDDLKGRIIGKDGRNMKAFEQIGGVDIVVDETPNTVVVSSFNPIRREIATRTLEQLIIDGRIQPIKIENELKKQEQELEYIIQETGLSTIKELNINDIDIELVKLIGKLKFRTSYGQNVLAHSIEVAKLSGAIASELGLDVEKAIRAGLLHDIGKAIDFEKQGSHVVLGAEIAKKYNEDPIIINCIESHHEDKEKESEIAAIVAIADSISASRPGARYNAIDEFILRMTEIEKIGNSIPGVAKTYALQSGRQIRLIVNPLVASDLDLAMILEKMKEEIKNKVIIPGEITITVIRERKETDVLK
What is the function of this protein?
Endoribonuclease that initiates mRNA decay.
What are the official names of this protein?
Ribonuclease Y, RNase Y.
What is the protein family that this protein belongs to?
Belongs to the RNase Y family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ARGB_MYCMM
Sequence: MTIETLSTQSKAQVLAEALPWLKQLHGRVVVIKYGGNAMTDDTLRQAFAADMAFLRNCGIHPVVVHGGGPQITAMLGKLGIEGDFKGGFRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGVTGEDAQLFTAVRRSVNVDGVATDIGLVGDVDHVNAAALMDLIAAHRIPVISTLAPDAEGVVHNINADTAAAALAEALGAEKLLMLTDVEGLYTSWPERDSLVREIDTAALEQLLPRLEAGMIPKVEACLRAVTGGVPSAHVIDGRVEHCVLVELFTNAGTGTKVVSA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURD_VIBA3
Sequence: MERWQNIQNVVVVGLGITGLSVVKHLVKYQPQTHVRVIDTRELPPGKESLPESVELHSGSWNSQWLAEADLVVANPGIALATSEIQDVIQAGTPVVGDIELFGWAVNKPAVAITGSNGKSTVTDLTGVLAKAAGLNVGVGGNIGIPALDLLELDADLYVLELSSFQLETTSSLNLAAAAFLNLSEDHMDRYQGMADYRDAKLRIFNNAQYAIVNREDKETYPDHSMPLVTFGLDDQEFGVATIDGTEWLTDNGKPVLPSQDLTLVGRHNVANALVSLALLKQVGIDYNKSLEALKAYNGLTHRCQVVANKREIKWVNDSKATNVASTLAALSGLEYQGTLYLLVGGVGKGADFSELKPVLAQLDRVQLCCFGEDAAQFMPLHPSAKTFDTMRDIIESISAQLVSGDMVMLSPACASFDQFNNFMARGDAFTELAHEYA
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FADJ_ECOLI
Sequence: MEMTSAFTLNVRLDNIAVITIDVPGEKMNTLKAEFASQVRAIIKQLRENKELRGVVFVSAKPDNFIAGADINMIGNCKTAQEAEALARQGQQLMAEIHALPIQVIAAIHGACLGGGLELALACHGRVCTDDPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALEMILTGKQLRAKQALKLGLVDDVVPHSILLEAAVELAKKERPSSRPLPVRERILAGPLGRALLFKMVGKKTEHKTQGNYPATERILEVVETGLAQGTSSGYDAEARAFGELAMTPQSQALRSIFFASTDVKKDPGSDAPPAPLNSVGILGGGLMGGGIAYVTACKAGIPVRIKDINPQGINHALKYSWDQLEGKVRRRHLKASERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQNCAAHTIFASNTSSLPIGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATTVKLAKKQGKTPIVVRDKAGFYVNRILAPYINEAIRMLTQGERVEHIDAALVKFGFPVGPIQLLDEVGIDTGTKIIPVLEAAYGERFSAPANVVSSILNDDRKGRKNGRGFYLYGQKGRKSKKQVDPAIYPLIGTQGQGRISAPQVAERCVMLMLNEAVRCVDEQVIRSVRDGDIGAVFGIGFPPFLGGPFRYIDSLGAGEVVAIMQRLATQYGSRFTPCERLVEMGARGESFWKTTATDLQ
What is the function of this protein?
Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA.  Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.  Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long-chain fatty acids.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.