PharMolix/UniProtQA huggingface dataset:
Protein: BRM1L_MOUSE
Sequence: MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDGDSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEYLEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSELEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDLDILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICIDRKDECPTSAVITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHS
What is the function of this protein?
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity.  When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth (By similarity).
What are the official names of this protein?
Breast cancer metastasis-suppressor 1-like protein.
What is the protein family that this protein belongs to?
Belongs to the BRMS1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOLE_YEAS6
Sequence: MHKGKKNYPNLITSFRMNLKKIILNHDRFSHPERWKTNALLRFTFVYIKFLFDLMIIKNPLRMVGKTNRDAVTALNSLQSNYANIMAIRQTGDRKNTMTLLEMHEWSRRIGYSASDFNKLNIVHITGTKGKGSTAAFTSSILGQYKEQLPRIGLYTSPHLKSVRERIRINGEPISEEKFAKYFFEVWDRLDSTTSSLDKFPHMIPGSKPGYFKFLTLLSFHTFIQEDCKSCVYEVGVGGELDSTNIIEKPIVCGVTLLGIDHTFMLGDTIEEIAWNKGGIFKSGAPAFTVEKQPPQGLTILKERAEERKTTLTEVPPFKQLENVKLGIAGEFQKSNASLAVMLASEILHTSNILEEKIKCSSNASIPEKFIIGLQNTKWEGRCQVLEKGKNVWYIDGAHTKDSMVAASTWFRDMVRLSKRKKILLFNQQSRDANALVNNLYSSVSPEITFDDVIFTTNVTWKSGSYSADLVSMNTSQEDVEKLKVQESLVKNWNKIDDNRAKTHVTASIEEANELIETLYDEPADIFVTGSLHLVGGLLVVFDRIDVK
What is the function of this protein?
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.  Required for methionine synthesis and maintenance of intact mitochondrial DNA.  Involved in telomere maintenance (By similarity).
What are the official names of this protein?
Folylpolyglutamate synthase, Folylpoly-gamma-glutamate synthetase, FPGS, Tetrahydrofolylpolyglutamate synthase, Tetrahydrofolate synthase.
What is the protein family that this protein belongs to?
Belongs to the folylpolyglutamate synthase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Mitochondrion matrix. Cytoplasm.
Protein: NRAM_I77AB
Sequence: MNPNQKIITIGSICMAIGIISLILQIGNIISIWVSHSIQTGSQNHTGICNQRIITYENSTWVNQTYVNISNTNVVAGKDTTSMTLAGNSSLCPIRGWAIYSKDNSIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPIGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDDGAVAVLKYNGIITETIKSWRKQILRTQESECVCVNGSCFTIMTDGPSDGPASYRIFKIEKGKITKSIELDAPNSHYEECSCYPDTGTVMCVCRDNWHGSNRPWVSFNQNLDYQIGYICSGVFGDNPRPKDGKGSCDPVNVDGADGVKGFSYRYGNGVWIGRTKSNSSRKGFEMIWDPNGWTDTDSNFLVKQDVVAMTDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPREKTTIWTSGSSISFCGVNSDTVNWSWPDGAELPFTIDK
What is the function of this protein?
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates.  Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release.  Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface.  These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.  Otherwise, infection would be limited to one round of replication.  Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors.  May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells.  Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport.  May additionally display a raft-association independent effect on budding.  Plays a role in the determination of host range restriction on replication and virulence.  Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
What are the official names of this protein?
Neuraminidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 34 family.
What are the subcellular locations of this protein?
Virion membrane. Host apical cell membrane; Single-pass type II membrane protein. Note=Preferentially accumulates at the apical plasma membrane in infected polarized epithelial cells, which is the virus assembly site. Uses lipid rafts for cell surface transport and apical sorting. In the virion, forms a mushroom-shaped spike on the surface of the membrane.
Protein: RUVC_ANAMF
Sequence: MMIIGIDPGLEFTGWGVVSSTNSQSVCLLDSGVISTRGISRESEKLYKIYVSLLSVLSLYKIDEASIEKVFINSNPRSSMSLCYARAASTISVMSRGIDIYEYSSTAIKKCITGSGMAPKEQVSFMVRSSLGIKQDVEINNHSSDAIAAALCHVYNTRNRNFALK
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: SAHH_GRAFK
Sequence: MSTKTVPYTAYKVKDIELAEYGRREIELAEAEMPGLMALRKEYGASKPLKGARIAGCLHMTIQTAVLIETLVELGANVTWSSCNIFSTQDHAAAAIAAAGIPVYAWKGLTEEEFNWCIEQTLFFGEDRKPLNMILDDGGDLTNMVLDEYPELAEGIKGLSEETTTGVHRLYERMKKGTLPMPAINVNDSVTKSKFDNKYGCRESAVDAIRRATDVMLAGKRVVVCGYGDVGKGTAQSFKGAGSIVTVTEIDPICALQAAMDGFEVKQLETVLPKADIVITTTGNKDIVRPEHFEAMKDKTIVANIGHFDNEIAVSWLNEKHGDSKVEIKPQVDKYTINGKDIILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELWKNTDEYKNEVYMLPKHLDEKVAKLHLERIGVELTELKQDQAEYIGVTVEGPYKPEYYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL13_BURO1
Sequence: MKTFSAKAHEVTREWYVIDATDKVLGRVASEVARRLRGKHKPEFTPHVDTGDFIIIINASKLKVTGNKTLDKKYYRHSGYPGGIYETTFGKMQERFPGRALEKAVKGMLPKGPLGYAMIKKLKVYAEATHPHSAQQPKALEI
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.
Protein: RRF_ORITB
Sequence: MNHEELINSLTKKMNGALQVLDADLKGLRVGQASAYFLDPVQVEAYNSRVPILQVATISVSDTKTILVQVWDKSLVKAVKKAIMEANLGVSIISDDNQIIRLQLPIPSEERRKELVKIAHKYQEKSKIIVRNIRRDGIELIKQMEQNTECSKDEAHIYSKEIQELTDKYCDKIDKIIKLKEQDIINL
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2722_YERP3
Sequence: MPQSSRYSDEHVEQLLSELVSVLEKHRTPTDLSLMVLGNMVTNLINTSIAPAQRKVLARSFAEALQASVREDKAH
What are the official names of this protein?
UPF0352 protein YpsIP31758_2722.
What is the protein family that this protein belongs to?
Belongs to the UPF0352 family.
Protein: H42_TETPY
Sequence: MAGGKGGKGMGKVGAKRHSRKSNKASIEGITKPAIRRLARRGGVKRISSFIYDDSRQVLKSFLENVVRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGG
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4, minor.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: SYGA_RHORT
Sequence: MAETPSFQSLILRLQQFWAAQGCVLLQPYDMEVGAGTFHPATTLRALGPEPWKAAYVQPSRRPTDGRYGENPNRLQHYYQFQVILKPSPADPQALYLDSLRALGIDPLKHDIRFVEDDWESPTLGAWGLGWEVWCDGMEVTQFTYFQQVGGFDCDPVPVEMTYGLERLAMYIQGVENVYDLDYNGAGVRYGDIFLQGEKEFSAHNFEYANTEALFRHFKDAEEECMALLAKGVPLPAYDQCIKASHRFNLLDARGVISVTERAAYIGRVRALAKGCCEGWLRARGHLPPLTGTEG
What are the official names of this protein?
Glycine--tRNA ligase alpha subunit, Glycyl-tRNA synthetase alpha subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIB_BRUME
Sequence: MRLLSLLTFSLFAVIGLAPAAQAKDKLTIYTYDSFVSEWGPGPKVKENFEKECDCEVNFVASADGVALLNRLKLEGSKTAADIVLGLDTNLTTEARASGFFAPSGIDQTNVKVPGNFKDDIFVPYDYGYFAVVYDSEKLPNPPKSLKELVEGDPAQKIVLQDPRTATPGLGMLLWMKSVYGDEAGAAWQKLQKRVLTVTPGWSEAYGLFTKGEAPMVLSYTTSPAYHMVVEKTNRYKALAYPEGNYLQIELAAQTTTGAKNPLAKKFLAFMTGPGFQDVIPETNWMFPAGKTSKPLPAAFDALPKPEKTLLIPPYEVAKNRRLWVNEWLAATSR
What is the function of this protein?
Part of the ABC transporter complex ThiBPQ involved in thiamine import.
What are the official names of this protein?
Thiamine-binding periplasmic protein.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 1 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: RLME_SHIB3
Sequence: MTGKKRSASSSRWLQEHFSDKYVQQAQKKGLRSRAWFKLDEIQQSDKLFKPGMTVVDLGAAPGGWSQYVVTQIGGKGRIIACDLLPMDPIVGVDFLQGDFRDELVMKALLERVGDSKVQVVMSDMAPNMSGTPAVDIPRAMYLVELALEMCRDVLAPGGSFVVKVFQGEGFDEYLREIRSLFTKVKVRKPDSSRARSREVYIVATGRKP
What is the function of this protein?
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase E, 23S rRNA Um2552 methyltransferase, rRNA (uridine-2'-O-)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TDCA_SHIFL
Sequence: MSTILLPKTQHLVVFQEVIRSGSIGSAAKELGLTQPAVSKIINDIEDYFGVELVVRKNTGVTLTPAGQLLLSRSESITREMKNMVNEISGMSSEAVVEVSFGFPSLIGFTFMSGMINKFKEVFPKAQVSMYEAQLSSFLPAIRDGRLDFAIGTLSAEMKLQDLHVEPLFESEFVLVASKSRTCTGTTTLESLKNEQWVLPQTNMGYYSELLTTLQRNGISIENIVKTDSVVTIYNLVLNADFLTVIPCDMTSPFGSNQFITIPVEETLPVAQYAAVWSKNYRIKKAASVLVELAKEYSSYNGCRRRQLIEVG
What is the function of this protein?
Transcriptional activator for the tdcABCDE operon.
What are the official names of this protein?
HTH-type transcriptional regulator TdcA, Tdc operon transcriptional activator.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: YG3O_YEAST
Sequence: MGKACLNKEVGTYECEGERDTYSFFTSLSDIQDSSSNEEQCGVGSILSEDSFTFEGSNVSIRLFSLDLNALNENENGSKNPVKFTIPPKIEQRKEARQREKRLRRVAVLPENSRNYLVESSMDSSREYSQPFFDWRHEMVEHGEESVKPCGCHKSRKAKCFKELEMENIEKGDIKKSLFYRDIIEWCRDYEVNKTREVCVPSIHEFYLHGNGSDNLF
What are the official names of this protein?
Uncharacterized protein YGR153W.
Protein: COABC_MYCTO
Sequence: MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAGHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLMASRIVDAIVTFLAGCSS
What is the function of this protein?
Catalyzes two sequential steps in the biosynthesis of coenzyme A.  In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.  In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
What are the official names of this protein?
Coenzyme A biosynthesis bifunctional protein CoaBC, DNA/pantothenate metabolism flavoprotein, Phosphopantothenoylcysteine synthetase/decarboxylase, PPCS-PPCDC.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PPC synthetase family.
Protein: MCHI_ECOLX
Sequence: MSYKKLYQLTAIFSLPLTILLVSLSSLRIVGEGNSYVDVFLSFIIFLGFIELIHGIRKILVWSGWKNGS
What is the function of this protein?
Protects a microcin H47-producer cell against microcin H47.
What are the official names of this protein?
Microcin H47 immunity protein MchI.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CCD97_HUMAN
Sequence: MEAVATATAAKEPDKGCIEPGPGHWGELSRTPVPSKPQDKVEAAEATPVALDSDTSGAENAAVSAMLHAVAASRLPVCSQQQGEPDLTEHEKVAILAQLYHEKPLVFLERFRTGLREEHLACFGHVRGDHRADFYCAEVARQGTARPRTLRTRLRNRRYAALRELIQGGEYFSDEQMRFRAPLLYEQYIGQYLTQEELSARTPTHQPPKPGSPGRPACPLSNLLLQSYEERELQQRLLQQQEEEEACLEEEEEEEDSDEEDQRSGKDSEAWVPDSEERLILREEFTSRMHQRFLDGKDGDFDYSTVDDNPDFDNLDIVARDEEERYFDEEEPEDAPSPELDGD
What are the official names of this protein?
Coiled-coil domain-containing protein 97.
Protein: GLGA_STRPS
Sequence: MKILFVAAEGAPFSKTGGLGDVIGALPKSLVKAGHEVAVILPYYDMVEAKFGNQIEDVLHFEVSVGWRRQYCGIKKTVLNGVTFYFIDNQYYFFRGHVYGDFDDGERFAFFQLAAIEAMERIDFIPDLLHVHDYHTAMIPFLLKEKYRWIQAYEDIETVLTIHNLEFQGQFSEGMLGDLFGVGFERYADGTLRWNNCLNWMKAGILYANRVSTVSPSYAHEIMTSQFGCNLDQILKMESGKVSGIVNGIDADLYNPQTDALLDYHFNQEDLSGKAKNKAKLQERVGLPVRADVPLVGIVSRLTRQKGFDVVVESLHHILQEDVQIVLLGTGDPAFEGAFSWFAQIYPDKLSTNITFDVKLAQEIYAACDLFLMPSRFEPCGLSQMMAMRYGTLPLVHEVGGLRDTVRAFNPIEGSGTGFSFDNLSPYWLNWTFQTALDLYRNHPDIWRNLQKQAMESDFSWDTACKSYLDLYHSLVN
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: Y529_METJA
Sequence: MAEYVFLIYLVDIKYQFRENMYKKLEIIERAILLNPQYIQAFREKLKITQSKLAKESGISQSHLSMLEKGKRPATKLIATAVTLGLLKCFSSNNVENPIIELLDALSLLKFEDTFAEFVSEIIEKGDKGYLRLIENYPVLIISKENLLNEMRSRLEVMDIERIELSRGRIKVIGKHLDNKYVEIFLDCSDIRRLEKKFMKKTGKKVIIQVFPKDEVPPIYSINKDCVIIHCW
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator MJ0529.
Protein: RL10_HAMD5
Sequence: MPLNLQDKKAIVDEVKEIAKGALSAVVADTRGVTVAKMTGLRKAAREAGVYMRVVRNTLMRRVVFSTDFECLQDTFVGPTLIAFSTEHPGAAARLFKEFAKLNKEFEIKAAAFEGTLIPVSDIDRLATLPTYEEAIARLMATLKEASVGKLVRTLAALKAKREAI
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: PLSB_PSEPF
Sequence: MTRSPFRRLVFGTLRRLLYLWVRSETINQSSFTLNLDRSRPVFYVLQNPSLTDLAVVDTECTKAGLPRPVLPVSVGSLIEPAAFFYLTPDPDWLGRQDKRGAPPTLTRLVSALSQNAAEDAQIIPVSVFWGQSPDSENSPWKLLFADSWAVTGRLRRLLSIMILGRKTRVQFSAPIHLRELIEHNKGHERTVRMAQRILRVHFRNLKAAVIGPDISHRRNLVKGLLNQPLVKQAILDEAERENISPEKAKAQALRYGNEIASDYTYTAIRFLEVVLSWFWNKIYDGIKVNHIEGVQKVAQGHEVIYVPCHRSHIDYLLLSYLLFRNGLTPPHIAAGINLNMPVIGSLLRRGGAFFMRRTFKGNPLYTSVFNEYLHTLFTKGFPVEYFVEGGRSRTGRMLQPKTGMLAITLRSFLRSSRMPIVFVPVYIGYERVLEGRTYLGELRGASKKKESIFDIFKVIGALKQRFGQVAVNFGEPIKLAEFLDSEQPGWRQQELGPQFKPAWLNETTNRLGEKVAQHLNEAAAINPVNLVALALLSTTRLALDDRAMARVLDLYLALLRKVPYSPHTTLPEGDGRALIEHVKDMDLLSEQNDALGKILYLDEQNAVLMTYYRNNVLHIFALPALLASFFQSTSRMSREQILRYTRALYPYLQSELFIRWTLDELDAVIDQWLEAFVEQGLLRFEKDVYLRPAPSSRHFVLLTLLSKSIAQTLQRFYMTVSLLLNSGQNSISAEELEDLCTVMAQRLSILHGLNAPEFFDKSLFRHFIQTLLDLDVLRRDEAGKLSYHELLGELAEGAAKRVLPAEIRLSIRQVALHRSEDAADQVAPPVQND
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, GPAT.
What is the protein family that this protein belongs to?
Belongs to the GPAT/DAPAT family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: HEM3_PAEMA
Sequence: MTKRTIVVGTRQSQLALTQTEQVIGDLKELCRAHGLPFEFEIKKIVTKGDRILDVTLSKIGGKGLFVKEIEQAMLDGEIDMAVHSMKDMPSVLPEGLINGGVPLRKDPRDALISRSGLHLHELPQGARVGTSTLRRSSQLLAYRPDLVLEPVRGNIDSRLRKLEEEGFDAIILAAAGLQRMGWENRVTAYLSADVCLPAVGQGALGIECRENDAELRDVLSLYNDPDTALTVAAERRFLAVLNGGCQVPIAAYANLERAGGQAPEEGGRAAASQAPAALRIRLTGMVGSADGRGYFEGECRREDPVAFGERIAGLLLAQGGRVT
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: PYRDB_EXIS2
Sequence: MNRLQVVLPGLNLKNPIIPASGCFGFGEEFAKLYDLSVLGGIMIKAATGEERYGNPTPRVAESGMGMLNAIGLQNPGVEGIIAQKLPFLRQFDTEIIANVAGSTPEEYEDVTRRISRDPVVKAIELNISCPNVKSGGLQFGTDPQMAAELTRRVKAVSEKPVYVKLSPNVTSIVEMAQAVEQAGADGLTMINTLVGMRIDVRTGQPILANRIGGLSGPAIKPVAVRMIHDVAQVVTIPIIGMGGVMEVDDVLEMIYAGASAVAIGTANFVNPFICQELITDLPKRMDELGIEHIMDIRGKAYGATLHRA
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit, DHOD B, DHODase B, DHOdehase B, Dihydroorotate oxidase B, Orotate reductase (NADH).
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4G2_HUMAN
Sequence: MESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD
What is the function of this protein?
Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection.  Cleaved by some caspases and viral proteases.
What are the official names of this protein?
Eukaryotic translation initiation factor 4 gamma 2, eIF-4-gamma 2, eIF-4G 2, eIF4G 2, Death-associated protein 5, DAP-5, p97.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic initiation factor 4G family.
Protein: NXRD1_MOUSE
Sequence: MEMLEDLESLRFEFGIPEEERYWLYLQGRYRGLMIKGCAHAAFFCKMFSTLSNLLQNLPRTIHPRTVSFDNAATEDELLTVGIIGCGHLGKQLTNVLLKTVPIPAENLQISTRRPESLGELRKLGVRCVYDNAAVASWAKVLFLCCLPAQLPNICLEIQSKLNKHCTVYSFVSAIPLPRLKSLLNHTNILRPQYQFAEDYDNIWGENEEVPIALQDTTIIRGTCPYNNLGGVILNVKWIEGLCYALINACTSRSVFHSQVLKLLNKLLLPMHLESCTTDPESCPQFNLTDFMSKSYVKNLYQKRPFPWFDLTTVQLKETPFSQHISATPSLQDHISLLYCEVFGLTISEEELPYISTVIRPLVEEK
What is the function of this protein?
Probable oxidoreductase.
What are the official names of this protein?
NADP-dependent oxidoreductase domain-containing protein 1, Pyrroline-5-carboxylate reductase-like protein C14orf148 homolog.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
Protein: RS6_YERP3
Sequence: MRHYEIVFMVHPDQSEQVPGMIERYSATITNAAGTIHRLEDWGRRQLAYPINKLHKAHYVLLNVEAPQEAIDELETNFRFNDAVIRSMVMRVKHAVTEASPMVKAKDERRERHDFASEANDDSEAGDSEE
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: ASNS_MOUSE
Sequence: MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQPIRVRKYPYLWLCYNGEIYNHKALQQRFEFEYQTNVDGEIILHLYDKGGIEKTICMLDGVFAFILLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVSLKHSTTPFLKVEPFLPGHYEVLDLKPNGKVASVEMVKYHHCTDEPLHAIYDSVEKLFPGFDLETVKNNLRILFDNAIKKRLMTDRRIGCLLSGGLDSSLVAASLLKQLKEAQVQYPLQTFAIGMEDSPDLLAARKVANYIGSEHHEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLKELYLFDVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPDMRIPKNGIEKHLLRETFEDCNLLPKEILWRPKEAFSDGITSVKNSWFKILQDYVEHQVDDEMMSAASQKFPFNTPKTKEGYFYRQIFERHYPGRADWLTHYWMPKWINATDPSARTLTHYKSAAKA
What are the official names of this protein?
Asparagine synthetase [glutamine-hydrolyzing], Glutamine-dependent asparagine synthetase.
Protein: TY21_PITAZ
Sequence: FPPWF
What are the official names of this protein?
Tryptophyllin-T2-1, Pha-T2-1, Tryptophyllin-11.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Tryptophillin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ACDH3_MYCVP
Sequence: MADKKSVAIVGSGNISTDLLYKLLRSEWLEPRWMIGIDPESEGLARARKLGLETSHEGVDWLLAQSELPDMVFEATSAYVHKAAAPRYAEAGIRAIDLTPAAVGPGVIPPANLRAHLDAPNVNMVTCGGQATIPMVYAVSRVVEVPYAEIVASVSSASAGPGTRANIDEFTKTTSAGVQNIGGAQRGKAIIILNPAEPPMIMRDTIFCAIPEHADHAAITQSIKDVVAEVQTYVPGYRLLNEPQFDEPSVVNGGNHVVTVFVEVEGAGDYLPPYAGNLDIMTAAATKVGEEIAKESLAATAGGAQA
What are the official names of this protein?
Acetaldehyde dehydrogenase 3, Acetaldehyde dehydrogenase [acetylating] 3.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: YM05_PARTE
Sequence: MKRFLNKINCSIKHNKSKFKLTFTKSKIRKNFKKMSIVKNVGSKNIEFHFNKKRSINTFLFTKVKKALNG
What are the official names of this protein?
Uncharacterized mitochondrial protein ORF5.
What are the subcellular locations of this protein?
Mitochondrion.