PharMolix/UniProtQA huggingface dataset:
Protein: PYRH_YERPP
Sequence: MATNAKPVYQRILLKLSGEALQGAEGFGIDASVLDRMAQEVKELVELGIQVGVVIGGGNLFRGAGLAQAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDNYSWAEAISLLRHNRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVKNPDATLYEQLTYQDVLEQELKVMDLAAFTLARDHNLPIRVFNMNKPGALRRVVMGENEGTLIAK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_STAA2
Sequence: MTKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITNEIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQIRSDLGRENVMYVHCTLLPYIKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECRDADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKYVSLQDAYLSVVESLKHAGYPFAKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRASEGKISAIKYARENNVPFFGICLGMQLATVEFSRNVLGLEGAHSAELDPATPYPIIDLLPEQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMVISGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: SYA_BLOPB
Sequence: MYKNIDDIRQEFLNFFKKKGHKIISSSTLIPNSDQTLLFTNSGMNQFKNIFLGIDKPLFKRVATAQRCVRAGGKHNDLNNVGYTERHLTFFEMLGNFSFGDYFKNEAIQFAWELLTDVNWFNLSKNKLWVTVHNCDGESYDIWSNQIDIPNEHIVKIGSNTNDFCDSDNFWQMGNIGPCGPCSEIFYDRGDRFQGGPPGSLEEFGERYVEIWNLVFIQFDRQENGRLLSLPMLSVDTGMGLERITSILQGVNSNFSIDVFKKLISSISRIMKINDIYINRSVYVIADHIRACSFLIQDGVLPANEGRGYVLRRIIRRAILHGKKLGVNDIFFYKLVSPLIKYMQHIADILHEKKDFIAEILLSEEKLFQDTLKRGLELLEKQLIRLKGNCLNGEIAFNLYDTYGFPFELTQDVCLKRGIHVDQEGFDQAMLTQKKYTKELNKFDISYEKLSLCNVSSIFVGYDKLICKSRVMALFQNNKSINKIYTKEEGIVILNNTPFYGESGGQIGDCGQLNTISGFFQVSNTKKYGQTIGHLGIVNSGTISVGEEIVAQVDQHKRKCISLNHSATHLLRAALSQVLGSHVTQKGSLVNDRYLRFDFYHHATMTTTQMNTVENIVNEQIWKNAPITVDVMPIELARNSGAVILINKQYDKKVRVLKIGNFSTELCGGTHAEHTGEIGVFMITKECSIAAGIRRVEAVTNNVALSAIHQYKMLLKNIFQSTQSDDKNILSKIHEFKCRYQKLEKEIDTLRNQQIIQQSLSFIKDVYYIKDVRILVKQVVNMTSKTLFNMTDCIKHQLKSGVIVLINLNTNKKINLVVAVTKDLIERNRINALSLVHYIIKILGGKGGGRPDFAQAGINNMATTSKISIEVNSLLHNIL
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_COXB2
Sequence: MSGGVKLIAGLGNPGDQYARTRHNVGAWFLETLAQQRNQSLAKENKFHGFVAKCNDYWLLKPTTFMNESGQAVAALARFYKIKPSEILIAHDELDFPAGDIRLKEGGGHGGHNGLRNIIQHLGSSDFYRLRIGINHPGHKDRVTPYVLSPPSENDRIAILAAIEKGLRLIPELVQGDFQKVMRELHS
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCSPA_RHORT
Sequence: MRYLPHSEADRAAMLATIGAASVEDLFRDVPREALDQAAFDALPDHGGEMEVERALSALAARNLTAGSVPCFLGAGSYRHHVPAAVDALIQRGEFLTSYTPYQAEVSQGTLQYLFEFQTQVALITGMEVANASMYDGATACAEAAAMAVRITRRRKVLMAGGLHPHYTATTQTLLACLGHEGEGLPPDPLALGDLIGRVGSDTACVIVQNPDFFGRLRDLSPLAEACHAAGALLVVAVCEPVSLGLVAPPGAMGADIVVAEGHALGSPTGFGGPGVGLFATREKYLRQMPGRLAGETLDESGKRGYVLTLSTREQHIRREKATSNICTNSGLIALAFTIHMTLLGEAGFTRLAWINHANAVALAEKLARVKGVKVLPETFFNEFTLRLPKPAAEVVEALAARSILAGVPVSRFLPTYPELANLLLVNATELTTPEDADALVAALKEVL
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: IOJAC_ARATH
Sequence: MASSTGLTVAGALLAGDFRLPAVSSLIPRKTSSSLSCLSNRDLSSPYNCCWRLSRGKILTSLSNSRKFAVGKEAEDGFLSNVSEDTDEMFDDLFNKYGKVVFRSTDVKSPTAEVDDDAESLAFAVELAKVASDVKAGDIKVLFVKPLVYWTRFFIIATAFSRPQIDAIGSRMRDLAEKKYGKVANGDVKPNSWTLLDFGDVVIHLFLPPQRTFYNLEDFYGNAMQIELPFEDQSQPRN
What is the function of this protein?
May be a ribosome silencing factor (Potential).  Involved in plastid biogenesis (By similarity).
What are the official names of this protein?
Protein Iojap, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the Iojap/RsfS family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: JMD6A_XENLA
Sequence: MNHKSKKRIKEAKRSARPELKDSQDWCRHNYCEVFSLNPSTVRDNVERADDAHLSIEEFIDRYEKPYKPVVIVNATADWPAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIDYMEGTRDDSPLYIFDSSYGEHPKRKKLLEDYEVPKYFRDDLFQFAGEKRRPPYRWFVMGPARSGTGIHIDPLGTSAWNSLVHGHKRWCLFPTNTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPSWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTAIAVTQNFASCSNFPVVWHKTVRGRPKLSRKWYRILKQERPELAALADTVDLQEATGIASDSSSDSSSSSSSSSSESCSEDDLSSGAEMMSHRKKKRKICSVMENGDSTTQDDCVSKERSSSR
What is the function of this protein?
Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase.  Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2.  Regulates RNA splicing by mediating 5-hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65.  Hydroxylates its own N-terminus, which is required for homooligomerization.  In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA.  Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation.  Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code.  However, histone arginine demethylation may not constitute the primary activity in vivo.  In collaboration with brd4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes.  Demethylates other arginine methylated-proteins such as esr1.  Has no histone lysine demethylase activity (By similarity).  Required for differentiation of multiple organs during embryogenesis.  Acts as a key regulator of hematopoietic differentiation (By similarity).
What are the official names of this protein?
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A, Histone arginine demethylase JMJD6-A, JmjC domain-containing protein 6-A, Jumonji domain-containing protein 6-A, Lysyl-hydroxylase JMJD6-A, Peptide-lysine 5-dioxygenase JMJD6-A, Phosphatidylserine receptor-A, Protein PTDSR-A.
What is the protein family that this protein belongs to?
Belongs to the JMJD6 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm.
Protein: CD40L_MACMU
Sequence: MIETYNQPSPRSAATGLPVRMKIFMYLLTIFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEEKKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL
What is the function of this protein?
Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
What are the official names of this protein?
CD40 ligand, CD40-L, Tumor necrosis factor ligand superfamily member 5.
What is the protein family that this protein belongs to?
Belongs to the tumor necrosis factor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Cell surface. SUBCELLULAR LOCATION: [CD40 ligand, soluble form]: Secreted. Note=Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and a matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
Protein: SLA1_SCHPO
Sequence: MANLPIIGIYKVLYSYEPQEINPGEEIPENEREISIVEDEIVCLLEKGEDDWYLVKRNVNSNDDDEEIGIVPSNYITEAEPSTKMKALYDYTQQSVDEISFQADQTLDCYGDTDSDWILVGFNNNFGLAPRNYVEGMDASSAPASQEPSASGVNAPTVSAPNSMVSPPPSFQPPSAAAPATSLPSDYNPPPPPPPPPAVEDQAADANEPDDYYSSGRAVSPEIPPTYTPKQADPLPAPPPPPPPTLPPQSTNTSQLPMPSRNVNNLGSQVNIPPPPATPSQPPRPPTNASTRSTGTSSSMAHSYDSPPSPSSPSDAYGDPNQHLKLRTDSHDDSRAYDSSSSMGNPAYEKWEVREVVGKKKKRTGILAINNKSIVLTFTKTMDAAQVWPVTDLVNYSSERKHVFIEFNSDSGITSLHLHASSNTNADNIIRALGDVAGSARAAGLREIAAASGSPMPKLPSDSALHRLNAASDAAGVNGGRTGDYEMSTVYGDRSARAEDHKPKDSSAGQKMGTVLYDFIAEAADELTVKANMRVVIVNDTASSDWWKCSVDGKEGVVPSNFIKPDTEGDAKSPPSSSKSGQGSSLSRRASKHESKHKRDSKHEARPESKHESHRESKSAEKDKKDKKDKKEDSKRSRSHSVSKPDSSKLRTWTDRTGAFKVEAEFLGYSDDKIHLHKTNGVKISVPSAKMSYKDLDYVELMTGKKVYSRTERKKDTQKQSHDHGHSHSKSHDREKEKEKKKDREHRKHRETEEEDEGPPPQPARPESTRPALAPPSSSHSNDKYDVIQERPKISYDWFDFFLRCGVDFTVCNRYTHNFNNEHLDEACIPSLNPDTLRTLGLKEGDIIRVMNHVNELNGVSTKPASAITPETKSTVNQIMSGGEALAAPVAVPAPIPAPVAEPAPPAAPAKEVVEKAPSPPATRPKSTTPQKFDDDAWANKPVTEPPVRASSVTVEPARVTESMNKMNISEEAKKPEAPSRPRTAPIPEPEEQKKAPVEKKDAEKSVQAPIPAQPTGNITIQNAYFTAPQPMAADPFQSPLYVQPTGFQPPPSALPIQPTGYMQPIPVQATGYQPLMVQPTGLQPHMTGVMPQVTGVMPQMTGVVPQMTGVMPQMTGVQVQKTGAMPQQPVNYGYQVAGMQPQATGIISQPTGIRAQATGIMTQPTGLHTQATGMMQPTGMQPQATGIMPQATGMMQPTGMQPQVTGIMPQSMPMQPQMTGVQVQKTGMVAQPMLSQYTGYQQNYTPTAMPAADGYGMQPSMNDTQAYYNMNAQTPVNYGFAGGQDTSFGYEQQQMYSPMQQQQQQYYGTEMQPDMGYQQPMMSNYYDPMQMQQQTPYGYNQTGMEGYSEYGYAQPAGNMANPMSYDPVSNASLYMPSDYNQQTQPANYYDSSFGGAQGANEAGKKASIYQATPDNPFGF
What is the function of this protein?
Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis.  The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton.  Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins.  Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
What are the official names of this protein?
Actin cytoskeleton-regulatory complex protein sla1.
What is the protein family that this protein belongs to?
Belongs to the SLA1 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches.
Protein: SLO1_YEAST
Sequence: MSAENISTGSPTGKQPSSEVNLGEREAGTKNERMMRQTKLLKDTLDLLWNKTLEQQEVCEQLKQENDYLEDYIGNLMRSSNVLEK
What are the official names of this protein?
SCOCO-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SLO1 family.
Protein: CMOB_TRIL1
Sequence: MNYYDALYPQLVAMGQERWAAQLQSTLSKQLLLERYGDMPEWLSALEALPQIQPSCIDLQDSVTIGSGSDLGRISSEELITLLQAFHPWRKGPYSLFGVEIETEWRSDWKWDRLLPHIQPLAGRRVLDVGCGNGYHGWRMRGVGADFVLGIEPFLVSVMQFQVMQRYLRDPQHQVIPIGVEDLPANLACFDSVFSMGVLYHRRSPLDHILELKGCLRPGGQLILETLIVEGDQETVFMPPGRYAKMRNVWFLPSIPAMTLWLQRCGFTEIACVNTNRTSHGEQHATDWMRFESLADYLDPDDESKTIEGHPAPLRAIFIATRP
What is the function of this protein?
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
What are the official names of this protein?
tRNA U34 carboxymethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Protein: EPAB2_RAT
Sequence: MWPSLSNELFPPPTEVWLQTVSSDPEAQGWGAWGRTEKTSLVPSAGSDKEAEENEDSSFLLSLLEPENLAKSPVYNQELEAIRLKLWTMEHAEVLPEPPSVQRKATEEERAEARELLSPETIGCFFPGAPKENVEADHRSVYVGNVDYGGSAAELEAYFSPCGEIHRVTILCDKFSGHPKGYAYIEFASKSSVQAAVRLDESTFRGRVIKVLPKRTNFPGISSTDRGGLRTHSSSRAAFLQGSLQRKPRLRPHGQSRGRGRASPWFSPY
What is the function of this protein?
Binds the poly(A) tail of mRNA.
What are the official names of this protein?
Embryonic polyadenylate-binding protein 2, Embryonic poly(A)-binding protein 2, ePABP-2, ePABP2, Embryonic poly(A)-binding protein type II, Poly(A)-binding protein nuclear-like 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RBFA_NOVAD
Sequence: MAKQQTSPETRSVRLLKVGEQVRHILSELLARQEVHDDVLSAHTVSVTEVRMSPDLRHATVFIKALLGEDEDLVLKALRTNTAFFQREVAQRLRLKYAARLKFLADESFDVASKIETLLADPKVQRDLRDQESDG
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_PSEA7
Sequence: MMDINEIREYLPHRYPFLLVDRVVELDIEGKRIRAYKNVSINEPFFNGHFPEHPIMPGVLIIEAMAQAAGILGFKMLDVKPADGTLYYFVGSDKLRFRQPVLPGDQLQLHAKFISVKRSIWKFDCHATVDDKPVCSAEIICAERKL
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YEGS_PSEAB
Sequence: MDKDKVLLVLHGKQAGNEEVRAAVAAQREAGRELAVRVTWEDGDARRIVEEALAAGFATLVAGGGDGTLREVAEALARGRGEASLAILPLGTANDFARAAGIPLEPAAALALLDQTARPIDLGAVNGKLFLNMATGGFGSKVTANTSEDLKKVLGGAAYLLTGLTRFSEVHAAQGRFSAPDFQWEGEFLALGIGNGRQAGGGHVLCPQARVDDGLLDVSILPTPQDMVGTLGTLLGGGNGVESLFVRARVPWLEVEAAEGLDVNLDGEPLEGRKLRFSVSPGALRVHLPAGSPLLREPPRED
What is the function of this protein?
Probably phosphorylates lipids; the in vivo substrate is unknown.
What are the official names of this protein?
Probable lipid kinase YegS-like.
What is the protein family that this protein belongs to?
Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS13_SHESW
Sequence: MARIAGINIPDQKHTVIALTAIFGIGRTRARAICAATAIAETAKIKELSEAQIDTLREEVAKYLVEGDLRREISMNIKRLMDLGCYRGLRHRRSLPLRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MURG2_BACAN
Sequence: MKKIVFTGGGSAGHVTPNLAIIPYLKEDNWDISYIGSHQGIEKTIIEKEDIPYYSIASGKLRRYFDLKNIKDPFLVMKGVMDAYVRIRKLKPDVIFSKGGFVSVPVVIGGWLNRVPVLLHESDMTPGLANKIALRFASKIFVTFEEAAKHLPKEKVIYTGSPVREEVLKGDREKALAFLGFSRKKPVITIMGGSLGAKKINETVREALPELLRKYQIVHLCGKGNLDDSLQNKEGYRQFEYVHGELPDILAITDFVISRAGSNAIFEFLTLQKPMLLIPLSKFASRGDQILNAESFERQGYASVLYEEDVTVNSLIKHVEELSHNNEAYKTALKKYNGKEAIQTIIHHISEA
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 2, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 2.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: VE2_OVPVD
Sequence: MSAAKEQLLAAQETQMTLIEKDSTDLKDHIDSWGPVRREHGLLYAARHKGLIWLGLNPVPPCSVKCLEARQAIEMQLLGNSLKESPWCNEPWSLCDLSWGRYQAPPAETLKKGARLVEVEYDGSSTNKTWYTAWNSLYLRKPDEEGWETATGGADADGLFYTTMSGTRVYYELFERDAARYSTTGTWTVRDNDRTYHSHSAPSHSRETIEGLWNSGGRERGRPTNSPDRAVLHTPPGGNTVHGPVRACENRGRSINRPTPYSTPQSPRSGVGPDTTSPLPSPVPQNPRCVSLPDGFGRGEEDNPPSPDQHDVIPNPQPKEPRFSLFGSSGGLPCLLISGTGNQVKCYSFRVKRWHRDKYHHCTTTWWAVGEQGSERPGDATVIVTFKDQSQRSMFLQQVPLPPGMSAHGVTMTVDF
What is the function of this protein?
Plays a role in the initiation of viral DNA replication.  A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity.  Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA.  E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome.  Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box.  Repression occurs by sterically hindering the assembly of the transcription initiation complex.
What are the official names of this protein?
Regulatory protein E2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E2 protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: MNMG_HELP2
Sequence: MVKESDILVIGGGHAGIEASLIAAKMGARVHLITMLIDTIGLASCNPAIGGLGKGHLTKEVDVLGGAMGIITDNSGLQYRVLNASKGPAVRGTRAQIDMDTYRILARNLVLNTPNLSVSQEMTESLIVENGEIVGVTTNINNTYKAKKVIITTGTFLKGVVHIGEHQNQNGRFGENASNSLALNLRELGFKVERLKTGTCPRVAGNSIDFEGLEEHFGDTNPPYFSYKTKDFNPTQLSCFITYTNPITHQIIRDNFHRAPLFSGQIEGIGPRYCPSIEDKINRFSEKERHQLFLEPQTIHKSEYYINGLSTSLPLDVQEKVIHSIKGLENALITRYGYAIEYDFIQPTELTHTLETKKIKGLYLAGQINGTTGYEEAAAQGLMAGINAVLALKNQAPFILKRNEAYIGVLIDDLVTKGTNEPYRMFTSRAEYRLLLREDNTLFRLGEHAYRLGLMEEDFYKELKKDQQAIQENLKRLRECVLTPSKEVLKRLNELDENPINDKVDGVSLLARDSFNLEKMRSFFSFLAPLNERVLEQIKIECKYNIYIEKQHENIAKMDSMLKVSIPKDFVFKGIPGLSLEAVEKLEKFRPKSLFEASEISGITPANLDVLHLYIHLRKNS
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS6_NITOC
Sequence: MSLAKRIIPCLDVANGRVVKGVRFVNIRDAGDPVEIARRYDEQGADEITFLDITASSDNRDTMVHVVEEVAAQVFIPLTVGGGIRYLEDIRRLLIAGADKVGINTAAVQRPELVREAAERFGSQCIVVAIDAKQVSSADEPPQWEVFTHGGRKETGLDAVAWARQMVEFGAGEILLTSMDRDGTREGFDLPLTRTISEAIPVPVIASGGVGTLEHLVAGILEGKADAVLAASIFHFGEYTIAEAKEHLSAHGIEMRQ
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KHSE_STRGC
Sequence: MKIIVPATSANIGPGFDSVGVAVSKYLTIEVLEERDEWLIEHDLNPRIPKDKRNLLIKVALQLAPNLQPYRLKMTSDIPLARGLGSSSSVIVAGIELANQLGKLDLTDDEKLDWANKIEGHPDNVAPAIFGNLVISSVFKGAVSSVRADFPECSFIAYVPKYELKTRDSRSVLPFKFSYKEAVAASSIANVAIAALLQGDLVKAGRAIESDRFHERFRQKLVREFPNIKKLAKKHGAYATYLSGAGPTIMILAPKDRAKLIQTRIEGCKYNGEVFILDVDRDGVRVEF
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD2_LACBS
Sequence: MGASEELEYLKSLVSQLNGKIAAIEAKAKGSPSPTPAQQLRTILIGPPGAGKGTQAPKIRDEFCVCHLATGDMLREQVQQKTPLGIEAKKIMDAGGLVSDDIMVGIIKDQLENNKSCKNGFVLDGFPRTIPQAQKLDGMLAERKEKIDSVVQLLIDDQLLISRITGRLVHPASGRSYHKEFNPPKKRNVDDVTGEPLIQRSDDNVETLTKRLRTFHSQTGPVVDYYKVKGLWHGIDAAQSPSVVWENLRSIFVSKK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
What are the official names of this protein?
Adenylate kinase, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate kinase cytosolic and mitochondrial, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Mitochondrion intermembrane space. Note=Predominantly mitochondrial.
Protein: BCSB3_KOMXY
Sequence: MKMVSLIALLVFATGAQAAPIASKAPAHQPTGSDLPPLPAAAPVAPAAQPSAQAVDPASAAPASDAGSASNADAILDNAENAAGVGTDVATVHTYSLQELGAQSALTMRGAAPLQGLQFGIPADQLVTSARLVVSGAMSPNLQPDNSAVTITLNEQYIGTLRPDPTHPAFGPLSFDINPIFFVSGNRLNFNFASGSKGCADPTNGLQWASVSEHSQLQITTIPLPPRRQLARLPQPFFDKTVRQKVVIPFVLAQTFDPEVLKASGIIASWFGQQTDFRGVNFPVFSTIPQTGNAIVVGVADELPAALGRPSVSGPTLMEVANPSDPNGTVLLVTGRDRDEVITASKGIGFGSSALPVASRMDVAPIDVAPRLANDAPSFIPTSRPVRLGELVPVSALQGEGYTPGVLSVPFRVSPDLYTWRDRPYKLNVRFRAPDGPILDVARSHLDVGINNTYLQSYSLREQSSVVDQLLRRVGVGTQNAGVEQHTLTIPPWMVFGQDQLQFYFDAAPLAQPGCRPGPSLIHMSVDPDSTIDLSNAYHITRMPNLAYMASAGYPFTTYADLSRSAVVLPDHPNGTVVSAYLDLMGFMGATTWYPVSGVDIVSADHVSDVADRNLIVLSTLSNSADVSALLANSAYQISDGRLHMGLRSTLSGVWNIFQDPMSVMSNTHPTEVETTLSGGVGAMVEAESPLASGRTVLALLSGDGQGLDNLVQILGQRKNQAKVQGDLVLAHGDDLTSYRSSPLYTVGTVPLWLIPDWYMHNHPFRVIVVGLVGCLLVVAVLVRALFRHAMFRRRQLQEERQKS
What is the function of this protein?
Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
What are the official names of this protein?
Cyclic di-GMP-binding protein, CDGBP, Cellulose synthase regulatory subunit, Cellulose synthase protein B.
What is the protein family that this protein belongs to?
Belongs to the AcsB/BcsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein.