PharMolix/UniProtQA huggingface dataset:
Protein: RTN3_PONAB
Sequence: MAEPSAATQSPSISSSSSGAEPSAPGGGGSPGACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE
What is the function of this protein?
May be involved in membrane trafficking in the early secretory pathway.  Inhibits BACE1 activity and amyloid precursor protein processing.  May induce caspase-8 cascade and apoptosis.  May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress.  Induces the formation of endoplasmic reticulum tubules.  Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition.
What are the official names of this protein?
Reticulon-3.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: ORF12_TTVV3
Sequence: MAWYWWRRRRRRGWWKPRRRRWRRRRARRRGPARRHRARRRSTDPNAPRETPRSKKKRPKKTQIQQSNSEDSSPGSTPVKKQKTKRRRYRRARYKNNFSSSSSSSDSSESSSSPLPKKSSKSGGGTASTPYYLPMHKQGLYV
What are the official names of this protein?
ORF1/2 protein.
Protein: METAS_ECOL5
Sequence: MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEYFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
What is the function of this protein?
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
What are the official names of this protein?
Homoserine O-succinyltransferase, HST, Homoserine transsuccinylase, HTS.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTHS1_LACAC
Sequence: MKSDIEIAQETKELPIEEIAAKVNLKKEDLEPYGQDKAKINWKAINRIRKNDKLGKLILVTSISPTPAGEGKSTITIGLGDAIHNQLHKNTLIALREPSMGPVFGLKGGATGGGRAQIIPMEDINLHFTGDMHALTAAIDTLAALVDNYIYQDNSLNIDPERILLKRGLDVNDRALRKITVGQGSKFNGIEHKASFAITVANELMAILCLANDINDLKARIGDMLVGYTQDDQPVYVKQLGFQGAIAALLSNALKPNLVQTLEHTPALVHGGPFANIAHGANSVMATNLALHLSDYVLTEAGFGSDLGGQKFMDFVSKHLDKTPDAAVVVATVRALKYQALGSTDKLDEENLDALKTGFKNLERHMNNMRSYNVPVIVLINRFDTDTDKELELLKELVEKQGIKAEVVTYHNEGSKGGSRAAQEVINLADSGKAELISTYNEDDDIKSKIKKIATKIYHADGVEYTDKAEEQIKELAKIGKDKLPVIIAKTQYSFSDDKKKLGAPGGFNLHVKGVSLKNGARFIVVTTGNVLDMPGLPKHPAALDIDVDNDGKISGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase 1, Formyltetrahydrofolate synthetase 1, FHS 1, FTHFS 1.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: PHNC1_PSESM
Sequence: MTLRLSAIDLRHSNGTLALRGLDLSIERGERVAIIGPSGAGKTTLLNLLASALPPSAGQLEVLGVNPWQLSSRQRQQLRSRIALIHQAPPLPARQRVVTAVSAGKLGQWGLGKSLLNLLHPLDVPGARAVLARLDLADKLFERCQQLSGGQLQRVGIARALYQAPELLLADEPVSAMDPRLADHTLALLCQHAIEHNVTLVASLHAVELALAHFPRIIGVRDGRIHFDLPAGEVERQHLDTLYANEQLSPQQVCEVAETVWAPRC
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC 1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: JMJ2_SCHPO
Sequence: MSKSTFHQTSPSFVQYTHATDKLKPAPHGMNTRGNNLSSMSKNTGQRKQRSKSIHGLPVAPVFYPDKEEFQDSIGYINKIAPIGEKYGIIKIVPPAGWNPPMQLDMNKFSFRTRRQDLHMMDLRFREIVSYDERVYRFFCNLGMELPESFFISNTSIDLYSLMRCIDSHASLSEKELKVHVWKRILRELSIPFTNASLKEASDLYLRYIFPFEDFVRKYQTSEDQCFETDLFPKFFTKDEHSNISIKDQKTSKQFNPETNESVGILQNQESKRNEQIKQQYMPADNFGSNDNHSHNKKRRLSSLSTNNNHLCDNCHKPVNCEVEDTCKEAYCTKCIINPYEFGFETGNYYTLSNFEKYCDNFKKNYFSKFKDSEITEDIVEKEYWKLVKDNNTSLEVEYGADLSTLDQGSAFPSLAKNPVNPYSKDTWNLNVIASTNGSLLSYIDNPVSGITCPWLYVGMCFSTFCWHVEDNYTYSVNYQHYGDTKLWYGIPGDQAERFERAALDIAPDLVKKQKDLLYQLATMINPDELQKRGVDVYFIDQGPNEFVITFPKSFHAGINHGFNINEAVNFAPKDWLLNGFSLNGVLKYQSLLKPPVLSHDMLVYNLATNPASEISVSELRPWVHEAVKRELGIRIMIRGRYDLKEILYRELMEDAENWQCQHCKAFSYFSQVACSCKSITVCPLHIEYLCKCDLSNKTLRLKVDDNELQKLLSY
What are the official names of this protein?
Jumonji/ARID domain-containing protein 2.
Protein: T22D1_BOVIN
Sequence: MKSQWCRPVAMDLGVYQLRHFSISFLSSLLGTENASVRLDNSSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGPTA
What is the function of this protein?
Transcriptional repressor (By similarity).  Acts on the C-type natriuretic peptide (CNP) promoter (By similarity).
What are the official names of this protein?
TSC22 domain family protein 1.
What is the protein family that this protein belongs to?
Belongs to the TSC-22/Dip/Bun family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: KDPA_YERPB
Sequence: MVASGFLLIASFMVVLFVLSRPLGGFLARLIEGEPFSALQKVEAGLWRCSGVKNAEMNGWQYALAILCFNLLGIVLLFVLLMTQGSLPLNPEHLPGMSWHLALNTAVSFVTNTNWQAYSGENTLSYLSQMAGLTVQNFLSAATGIAVAFALIRAFARHSATTLGNAWVDLVRITLYVLLPIALIIALIFVSQGVLQNLDGYLHITTLEGVQQTLPMGPVASQEAIKVLGTNGGGFFGANSAHPFENPTAFSNFVQMLAIFLIPCALCFAFGQVVGDNRQGHALIWAMSLIFIVAVVVVMYAELAGNPHLSPLGADSNSNMEGKESRFGILATSLYAVVTTAASCGAVNAMHDSFTALGGMIPLWLMQIGEVVFGGVGSGLYGMLLFVLLTVFIAGLMIGRTPEYLGKKIDVFDMKMTALAILVTPTIVLLGTALALCTEAGRAGILNPGAHGFSEVLYAFSSAANNNGSAFAGLSVNTPFYNLLLAAAMFIGRFGVILPVLAIASSLVAKKRQPAGNGTLPTGGPLFIGLLIGTVLLVGALTFIPALALGPVAEHLQVWLAH
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
What are the official names of this protein?
Potassium-transporting ATPase potassium-binding subunit, ATP phosphohydrolase [potassium-transporting] A chain, Potassium-binding and translocating subunit A, Potassium-translocating ATPase A chain.
What is the protein family that this protein belongs to?
Belongs to the KdpA family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: KAD_CUPTR
Sequence: MRLILLGAPGAGKGTQAKFICEKFGIPQISTGDMLRAAVKAGTPLGVEAKKVMDAGGLVSDDIIIGLVKDRLKQDDCKSGYLFDGFPRTIPQAEAMKDAGVAIDYVLEIDVPFDAIIERMSGRRVHVASGRTYHLKYNPPKTEGVDDETGEPLIQRDDDKEETVKKRLDVYSQQTRPLVDYYSAWAANGDPAAKVAPPKYRKILGVGNVDEITARVFEALK
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B2KB7_SICCD
Sequence: WIMGHMVNAIEQVDEFLNLGANAIEFDIDFDKDGIAQITHHGIPCDCGRKCTKKAIFTEYLDNIRQVTTPDDPKFREQLVLLALDLKLQRISSAKAYRAGEDVAKKLLDHYWQRGNSRARAYILLNIPLVEDYEFIRAFKDTLKNEGYESYNDKVGINFTGNEDLDKIRDVLEILGIHKQVWQADGITSCFARGTERLKEALEKRDTPGYNYINKVYAWTLVRKSIMRRSLRLGVDGVMSNNPDRVIKVLKEKEFADKFRLATYNDNPWEKFRG
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SdSicTox-betaIIB1bvii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PHM8_YEAST
Sequence: MTIAKDYRTIYRNQIKKQIRLNQEHLQSLTHLGSQINFEVDPPKLPDPDPARKVFFFDIDNTLYRKSTKVQLLMQQSLSNFFKYELGFDDDEAERLIESYYQEYGLSVKGLIKNKQIDDVLQYNTFIDDSLPLQDYLKPDWKLRELLINLKKKKLGKFDKLWLFTNSYKNHAIRCVKILGIADLFDGITYCHYDRPIEEEFICKPDPKFFETAKLQSGLSSFANAWFIDDNESNVRSALSMGMGHVIHLIEDYQYESENIVTKDHKNKQQFSILKDILEIPLIMDVEVYRPSSIAIKEMEELEEEGEAVNWSNQQINVQSS
What is the function of this protein?
May be involved in phosphate metabolism.
What are the official names of this protein?
Phosphate metabolism protein 8.
What is the protein family that this protein belongs to?
Belongs to the SSM1 family.
Protein: FABZ_RHIL3
Sequence: MTEEATTTLSSADIIEIMKLLPHRYPFLMVDKIIEIDGDNTAIGIKNVTVNEPHFTGHFPESPIMPGVLLIEGMAQTAGAICAKKDGQPGNLVYFMTIENARFRKPVVPGDRVEFHVRKHKQRGNIWKFHCDAKVDGALVAEADIGAMIVRKDQA
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURR_ALISL
Sequence: MATIKDVAKLASVSTTTVSHVINKTRFVAEATQKRVWEAVEELNYAPSAVARSLKCNTTRTIGMLVTQSFNPFFAEMMHGVENYCYKQGYTLFMCNTEGDLDKQKHYLRMLAEKRVDGLLVMCSDLNEQLLAQLEKNTELPMVIMDWGPDSPHTDKIIDNSEEGGYLATKHLIENGHTKIGCVTGQLDKATCKERIHGFYRALSEANLTSNPDWIFEGDFECSSASKSVEKMLQMEDKPTALFCFNDIMALAAISKIQQTGLRVPEDISIIGYDNIELSAYFSPPLTTIHQPKRRVGKTAVEILLERIKDKHHERRIFEMHPEVVTRKSVHKL
What is the function of this protein?
Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression.  PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
What are the official names of this protein?
HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor.
Protein: STHA_ECO45
Sequence: MPHSYDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYQNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNARFVDEHTLALDCPDGSVETLTAEKFVIACGSRPYHPTDVDFTHPRIYDSDSILSMHHEPRHVLIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALQNIGLETDSRGQLKVNSMYQTAQPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
What is the function of this protein?
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
What are the official names of this protein?
Soluble pyridine nucleotide transhydrogenase, STH, NAD(P)(+) transhydrogenase [B-specific].
What is the protein family that this protein belongs to?
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MUTL_ECOL5
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGCGIKKDELALALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTAEQQEAWQAYAEGRDMDVTVKPAAHPVGTTLEVLDLFYNTPARRKFLRTEKTEFNHIDEIIRRIALARFDVTISLSHNGKIVRQYRAVPEGGQKERRLGAICGTAFLEQALAIEWQHGDLTLRGWVADPNHTTPALAEIQYCYVNGRMMRDRLINHAIRQACEDKLGADQQPAFVLYLEIDPHQVDVNVHPAKHEVRFHQSRLVHDFIYQGVLSVLQQQLETPLPLDDEPQPAPRAIPENRVAAGRNHFAEPAVREPVAPRYSPAPASGSRPAASWPNAQPGYQKQQGEVYRQLLQTPAPMQKPKAPEPQEPALAANSQSFGRVLTIVHSDCALLERDGNISLLSLPVAERWLRQAQLTPGEVPVCAQPLLIPLRLKVSGEEKSALEKAQSALAELGIDFQSDAQHVTIRAVPLPLRQQNLQILIPELIGYLAKQSVFEPGNIAQWIARNLMSEHAQWSMAQAITLLADVERLCPQLVKTPPGGLLQSVDLHPAIKALKDE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: LIPA_PLAKH
Sequence: MRVLTPSLYIYAFFIFCVRFKCGNRTTVASAIRASYDMPPKELRVGDMLKKTSQPNCNYRTRGKCRKFFFVWKLDKMRDAHLGVQAKRRKNHLRSGSATYEASLGEHQLKGKRKESATNVEKEKKEKEQQEERLPVPKVGNKMPEKKPDWFHVPAPTGKKYNKLKEDLKKLKLHTVCEEAQCPNIGECWNIGTATIMLLGDTCTRGCKFCSIKTSSKPLAPDANEPFNTAKAICEWDINYVVLTSVDRDDLPDGGASHFAKTIELIKFSRPEILIECLVSDFQGNVDSIRKLANSGMEVYAHNIETVRRLQKFVRDRRANYEQSLRVLKIAKEINPMLYTKTSIMLGLGETKEEVLEAMSDVRQHNIDVITFGQYLRPTKNHLNVVEYVSPQMFDFYKEEGMKMGFKYIASGPLVRSSYKAGEYFMKSLVEQRRGAKTHAQG
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, apicoplast, Lipoate synthase, LS, Lip-syn, Lipoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Plastid, apicoplast.
Protein: RS5_PASMU
Sequence: MANIEKQAGELQEKLIAVNRVSKTVKGGRIMSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMINVALNEGTLQHPIKGAHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVRNVLSKAYGSTNPINVVRATIDALANMKSPEMVAAKRGKTVDEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: RS8_STAA8
Sequence: MTMTDPIADMLTRVRNANMVRHEKLELPASNIKKEIAEILKSEGFIKNVEYVEDDKQGVLRLFLKYGQNDERVITGLKRISKPGLRVYAKASEMPKVLNGLGIALVSTSEGVITDKEARKRNVGGEIIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: LDH_DEIRA
Sequence: MKVGVVGTGFVGSTAAFALVLRGSCSELVLVDRDEDRAQAEAEDIAHAAPVSHGTRVWHGGHSELADAQVVILTAGANQKPGESRLDLLEKNADIFRELVPQITRAAPDAVLLVTSNPVDLLTDLATQLAPGQPVIGSGTVLDSARFRHLMAQHAGVDGTHAHGYVLGEHGDSEVLAWSSAMVAGMPVADFMQAQNLPWNEQVRAKIDEGTRNAAASIIEGKRATYYGIGAALARITEAVLRDRRAVLTVSAPTPEYGVSLSLPRVVGRQGVLSTLHPKLTGDEQQKLEQSAGVLRGFKQQLGL
What is the function of this protein?
Catalyzes the conversion of lactate to pyruvate.
What are the official names of this protein?
L-lactate dehydrogenase, L-LDH, 2-ketoacid:NAD-dependent dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. LDH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TGT_STRPI
Sequence: MSDSPIKYRLIKKEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEMGSGIILSNTYHLWLRPGDELIARAGGLHKFMNWDQPILTDSGGFQVYSLADSRNITEEGVTFKNHLNGSKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLKAHRRPHDQGLFGIVQGAGFEDLRRQSAHDLVSMDFPGYSIGGLAVGETHEEMNAVLDFTTQLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTSQGRLVVKNAQFAEDFTPLDPECDCYTCKNYTRAYLRHLLKADETFGIRLTSYHNLYFLLNLMKQVRQAIMDDNLLEFREYFVEKYGYNKSGRNF
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: Y4316_ARATH
Sequence: MDDVTPDELEAVSVLLRLPNPVFFDQEEEEEDEEEEYDEESVCEDDLEVKSCMQTNENKGKKRKVAEQLMDSDVKDNQYRLMLGKEPVKKMMDALGKTEKLGTKGLNVSVYGPNGENHKMVLKIWIKGTPVLTSGWKNFVKSYKLEKHVDFLTIWMFRHKKTREICFAIDSTRFPVKGTLSKRILQEVFKNP
What are the official names of this protein?
Putative B3 domain-containing protein At4g03160.
What are the subcellular locations of this protein?
Nucleus.
Protein: CONG2_LUPAL
Sequence: MAKNMAQIFPFIAVFLSCSFIFVLSSSQNSQSLYHNPQSTSSSSSKPSLLVLPIQQDASTGLHWANIHKRTPLMQVPVLLDLNGKHLWVTCSYHYSSSTYQAPFCHSTQCSRANSHHCFTCTDSATSRPGCHNNTCALMSSNPVTQEAGFGELAQDVLAIHSTHGSKLGPMVRVLQYLFSCAPSFLAQKGLPNNVQGPLGLGHAPISLQNQLFSHFGLKRQFAMCLSRYPTSNGAILFGDIYDLDNNYIHNSIDVLIDMVYTPLRISQQGEYFMQVNAIRVNKHMVVPTKNPSMLSSYHGDSRIGGAMITTTNPYTILHHSIFEVFTQVFANNMPKEAQVESVGPFGLCYDSRKLSGGIPSVEFVMDSHDDVWRISDENLMVQAQNGVSCLGFVDGGMHTRTEIVLGTHQLEENMVVFDLERSRVEFNSNSLKSHGKTCANIFDLNNA
What is the function of this protein?
Sulfur-rich seed storage protein that remains undegraded at germination.
What are the official names of this protein?
Gamma conglutin 2, Conglutin gamma 48.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted, extracellular space. Note=Present in the extracellular spaces of germinating cotyledons and in the young roots.
Protein: RLMF_SHEAM
Sequence: MAPFFSAMTSKKQSQGLPKGPHPDNAHRDGYDFSALVASHPPLKPFVRANAYGNLSIDFALPEAVKALNCALLKHHYGISRWDIPKGFLCPPIPGRVDYLHHLEDLLRQTPGTDGLPLLDIGTGANGIYALLAASRFGRAVVATDIAKASLTNVATILKANPGLEKRISLRFQSNPRHILTGVTQTNEQFAACVCNPPFHASAAEAALGTNRKLEGLAKSRGQRHISGPGKPQTLNFGGQDAELWCDGGERSFLLRLIDESARLPDLCVWFTTLVSKSDNLRPCKRRLEQRGASEIKVIEMQQGQKITRILAWRFESVT
What is the function of this protein?
Specifically methylates the adenine in position 1618 of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase F, 23S rRNA mA1618 methyltransferase, rRNA adenine N-6-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. METTL16/RlmF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVA_MYCGA
Sequence: MITSVYAKIEYVTNTKMLFVANNWGYWVNVKPNSGFSRTDNNVLVFLHELTFLAQNNAINKELYAFKSLKEKEWFKALLTINGIGPKTAMNVMVNKQEEVLTLIKNNDLNGLLRLENINKKVATMLLASDIASKHYLKNQIVVSDKVEPQIDDDEKIDDSKDLNDDELLSEIVIEAIDCLISLGYKQEQIKTALAEIDLKNESINDSADLVAVIIKQIGLRTSEVS
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: RL10_BOVIN
Sequence: MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGHMVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFENMVAEKRLIPDGCGVKYIPNRGPLDKWRALHS
What is the function of this protein?
Component of the large ribosomal subunit.  Plays a role in the formation of actively translating ribosomes.  May play a role in the embryonic brain development.
What are the official names of this protein?
60S ribosomal protein L10, Protein QM homolog, Ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: PSBF_PIPCE
Sequence: MTIDRTYPIFTVRWLAVHGLAVPTVSFLGSISAMQFIQR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: QUEC_BACC3
Sequence: MKKEKAVVVFSGGQDSTTCLFWAIEQFAEVEAVTFNYNQRHKLEIDCAAEIAKELGIKHTVLDMSLLNQLAPNALTRTDMEITHEEGELPSTFVDGRNLLFLSFAAVLAKQVGARHIVTGVCETDFSGYPDCRDVFVKSLNVTLNLSMDYPFVIHTPLMWIDKAETWKLSDELGAFEFVREKTLTCYNGIIGDGCGECPACQLRKAGLDTYLQEREGASN
What is the function of this protein?
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
What are the official names of this protein?
7-cyano-7-deazaguanine synthase, 7-cyano-7-carbaguanine synthase, PreQ(0) synthase, Queuosine biosynthesis protein QueC.
What is the protein family that this protein belongs to?
Belongs to the QueC family.
Protein: SYC_BART1
Sequence: MMKELRFYNTLTRKKENFIPIDPTKVRLYVCGPTVYDYAHIGNARPLIVFDILFRLLRHVYGSDHVLYARNITDVDDKINARAACEYPNLPLNEAIRQLTERTYFQFQQDTIALGCLLPTSQPRATEHLEEMRALIERLLEKGHAYKAENHILFSISSIKNPPHYGAFANRSLDEMRAGARIDVAAYKREEMDFVLWKPSAEGEPGWKSPGGIPVLGRPGWHIECSAMSMAKLLAPYGGGLTCDDPIANIFDIHGGGLDLIFPHHENEIAQSCSAFGTERMANFWMHNGFLQVEGKKMSKSFGNFITIRSVLENNFLEFNGALAYEIKQNWAGLSARFSMLQTHYREPLNWTAQRLMQSSSELYRWYELLRDKKSMMENNEAIEDTLIDALSDDLNTPKAFTLLRKFYKAGDALALANGMNLLGLLRQEWIKEIDCPLFIKKTSLDSKFIEQCIAERLRLIHNKEWGAADKIRNELAAEGILLKDGKDPQSGKRITVWEIKRF
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.