PharMolix/UniProtQA huggingface dataset:
Protein: RS10_BURP0
Sequence: MQQQKIRIRLKAFDYRLIDQSAAEIVDTAKRTGAIVRGPVPLPTRIQRFDILRSPHVNKTSRDQLEIRTHQRLMDIVDPTDKTVDALMKLDLPAGVDVEIKLQ
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: SCAF_PSHV1
Sequence: MVVAEQLEDVFVGGYLVIYASQDGAGEEYRLPKEVVARALPVEPGRVPVNINHDASCRVGSVISIVDVEKGLFFLGVVSGSLALAMFKYVARDLFRADDGDSPGGGAESETRSDEALPANTLSEREKFLYLLSNVLPSLSLSSARLADGYSPADDFFAHVALCELGKRDGTIAIYGSSPPEVLDAFSGLDDAAKRELARSAEEWTTSSRREEPVDEAMVSECLLRKFMNNAFLMDRGEYLRARRHLADVRRPKYLQAAETTCLSSANPRSSGKAAFSCEARGLDEAGAGAIGRAPESGMAASADQHAQDGIKIRLERSRSQIGPGAMSSVSQPAAAPYSGAMADSAAQVPSAQPPRIPCPPTGQTEMIYVPLGTYNDLVVSAAQARRGEDRRQQLSAPPPQHAQQIVQRETGINSSSPALAPAGRGSYASASHIMHQPAFQTQQPCWPQQQQYVQAPCGGHGIGYYGQAVSRRGGSSGDGAPTTRSTGAPGAGGLSMFGMQHAGPQTHFTAPLHGLPTGFPAHGSFLHAPGYLGAMPPIQVYAPQPQQHPPSLDTRIEALLAALEKERASEQGAAEGPQQSLVAGQNKKKALLKRSMEHQREEEEDDESAPEAPYFPGEAAASCKRQAKRQRAAAEGEEQVAPSFSDLIQGLAALHKDVAEMKASVAGIGAPQASQPTPVAQPEHEEPKQAPATVDASSSKKLKDSRRAAEKRRAADEFARIMSTE
What is the function of this protein?
Plays a major role in capsid assembly.  Acts as a scaffold protein by binding major capsid protein.  Multimerizes in the nucleus such as major capsid protein forms the icosahedral T=16 capsid.  Cleaved by assemblin after capsid completion.  The cleavages products are evicted from the capsid before or during DNA packaging.
What are the official names of this protein?
Capsid scaffolding protein, Capsid protein P40, Protease precursor, pPR.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae capsid scaffolding protein family.
What are the subcellular locations of this protein?
[Capsid scaffolding protein]: Host cytoplasm. SUBCELLULAR LOCATION: [Assemblin]: Host nucleus. SUBCELLULAR LOCATION: [Assembly protein]: Host nucleus.
Protein: FOLD_GEOKA
Sequence: MTAQIISGTEMARTIRTALADEAAQLKADGVEPGLAVILVGDDPASHSYVKGKQKACAEVGIRSFLYTFPAAIDEETLLAKIRELNVDPAVHGILVQLPLPDHICEWSVIETIAPEKDVDGFHPINVGKMMIGQRAFLPCTPHGILVMVQSAGIDIAGKHVVVVGRSNIVGKPVGQLFLREHATVTYTHSKTPDLAAITRQADILIVAVGKARLIGPEHIKPGAVVIDVGVNRLENGKLCGDVDFDAVKEVAGYITPVPGGVGPMTITMLLHNTIEAARQLAAK
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SPRNG_HUMAN
Sequence: MVNLAAMVWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRDRNLLQVHDHNQPIPWKVQFNLGNSSRPSNQCRNSIQGKHLITDELGYVCERKDLLVNGCCNVNVPSTKQYCCDGCWPNGCCSAYEYCVSCCLQPNKQLLLERFLNRAAVAFQNLFMAVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA
What is the function of this protein?
Positively regulates hepatic SREBP signaling pathway by modulating the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP.
What are the official names of this protein?
SREBP regulating gene protein, SREBF pathway regulator in Golgi 1.
What is the protein family that this protein belongs to?
Belongs to the SPRING family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass membrane protein.
Protein: ATPB_THEVB
Sequence: MVISAERTNVGFITQVIGPVVDIEFPSGKMPAIYNALRIQGKNAAGLDVAVTCEVQQLLGDNRVRAVAMSSTDGLVRGMEVVDTGAPISVPVGTATLGRIFNVLGEPVDEKGAVNATETLPIHRPAPSFTQLETKPSVFETGIKVIDLLTPYRRGGKIGLFGGAGVGKTVIMMELINNIATQHGGVSVFAGVGERTREGNDLYNEMIESGVIDKDDPSKSKIALVYGQMNEPPGARMRVGLSGLTMAEYFRDVNKQDVLLFIDNIFRFVQAGSEVSALLGRMPSAVGYQPTLGTDVGALQERITSTTEGSITSIQAVYVPADDLTDPAPATTFAHLDGTTVLSRSLAAKGIYPAVDPLGSTSNMLQPDIVGEEHYQTARAVQATLQRYKELQDIIAILGLDELSEEDRLTVARARKIERFLSQPFFVAEVFTGAPGKYVTLEETIKGFQMILSGELDDLPEQAFYMVGNIEEAKAKAEKLKA
What is the function of this protein?
The complex from the organism is particularly stable to disruption and remains functional after 6 hrs at 55 degrees Celsius.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: PX11B_MOUSE
Sequence: MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLEGHLSLGRKLLRLGNSTDALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQETSAYSRRMKVSGVGVSGGVETVGPGGPGTPGGSLPQLALKFRLRILLLARVLRGHPPLLLDVLRNACDLFIPLDKLGLWRCGPGIVGLCGLISSILSILTLICPWLRLKP
What is the function of this protein?
Involved in peroxisomal proliferation.  May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane.  Promotes membrane protrusion and elongation on the peroxisomal surface.
What are the official names of this protein?
Peroxisomal membrane protein 11B, Peroxin-11B, Peroxisomal biogenesis factor 11B, Protein PEX11 homolog beta, PEX11-beta.
What is the protein family that this protein belongs to?
Belongs to the peroxin-11 family.
What are the subcellular locations of this protein?
Peroxisome membrane; Single-pass membrane protein.
Protein: KAD_PSEA8
Sequence: MRVILLGAPGAGKGTQARFITEKFGIPQISTGDMLRAAVKAGSPLGQQVKGVMDSGGLVSDDIIIALIKERITEADCAKGFLFDGFPRTIPQAEALKDAGVTIDHVVEIAVDDEEIVSRIAGRRVHPASGRVYHTEHNPPKVAGKDDVTGEELIQREDDKEETVRHRLSVYHSQTKPLVDFYQKLSAAEGTPKYHSIAGVGSVEQITAKVLSALS
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
What are the official names of this protein?
Adenylate kinase, AK, ATP-AMP transphosphorylase, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_ECOLI
Sequence: MSMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFKVEGDTKPELELTLKYFQGKAVVESIQRVSRPGLRIYKRKDELPKVMAGLGIAVVSTSKGVMTDRAARQAGLGGEIICYVA
What is the function of this protein?
Protein S8 is a translational repressor protein, it controls the translation of the spc operon by binding to its mRNA.
What are the official names of this protein?
30S ribosomal protein S8, Small ribosomal subunit protein uS8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: CAZA2_NOTEU
Sequence: MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEEQVLITEHGDLGNGKFLDPKNRVSFKFDHLRKEATDPRPCEGENAIESWRHSVETAMRAYVKEHYPNGVCTVYGKTIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQESLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-2, CapZ alpha-2.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
Protein: YMGG_ECO27
Sequence: MKKKILAFGLISALFCSTPAMADMNRTTKGALLGAGVGLLTGNGVNGVLKGAAVGAGVGAVTEKGRDGKNARKGAKVGAAVGAVTGVLTGNGLEGAIKGAVIGGTGGAILGKMK
What are the official names of this protein?
UPF0757 protein YmgG.
What is the protein family that this protein belongs to?
Belongs to the UPF0757 family.
Protein: LEO1_DANRE
Sequence: MADMDELFGSDGDSDNEQRDSGSGSGSDSDHERPRSASNASGSESAQSDRDHDDDEDEDGGKPSNKELFGDDSEDEHGSQHSGSQHSGSRHSGSRHSGSRHSGSRHSGSQHSGSQSERSGNQSDATMHSDNEHSMSEAHRGEQDDEDDDDRGHRSDVGSPASGAGSRRSDRGSGSPGSEAGSPRSEAGSGHSDPGTPHTDGEGSGKDAHSGDEKWGGDGKSDQSEDEDKQQNSDDERERSDEEGERQKSESIKGSDSEDDFTRKKKKKIASDSDSDSDAETQGGKKPAANDLFGEADDISSDSDAEKPLTPGQPLDADDGMEGDQPEEEPAPETRIEVEIPKVSTDLGSDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRSRRDEEGNEVKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPESQRNEMIKKEEERLRASIRRESQQRRMREKQHQRGLNAGYLEPDRYDEDEEGEESISLAAIKSKYKGGGGLREERARIYSSDSDEGSDEDKAQRLMKAKRLDSDEEGENSGKRKAEEDEESASKKPKKYVISDEEDEDGDGERDGDRERGGDMDGDGDGDMEGDGDVDRDGDMDGDGEGDGEGDGEEDE
What is the function of this protein?
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II.  PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).  PAF1C seems to be required for multiple steps in cardiac formation.  Involved in heart development and required for differentiation of the atrioventricular boundary.  Required for neural crest cell development.
What are the official names of this protein?
RNA polymerase-associated protein LEO1.
What is the protein family that this protein belongs to?
Belongs to the LEO1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SYDND_BURA4
Sequence: MSMRTEYCGLVTEHLLGQTVSLCGWVQRRRDHGGVIFIDLRDREGLVQVVCDPDRAEMFATAEGVRNEFCVQIKGLVRNRPEGTVNAGLKSGKIEVLCHELNVLNASVTPPFQLDDDNLSETTRLTHRVLDLRRPQMQHNLRLRYRVAIEARKYLDEQGFIDIETPMLTKSTPEGARDYLVPSRVNAGQFFALPQSPQLFKQLLMVANFDRYYQITKCFRDEDLRADRQPEFTQIDCETSFLGEQEIRDLFEDMIRHIFKTTIDVELDAKFPVMPYSEAMARFGSDKPDLRVQLEFTELTDAMKDVDFKVFSTPANAKDGRVAALRVPKGGELSRGDIDGYTEFVRIYGAKGLAWIKVNEKAKGRDGLQSPIVKNLHDASIAAILERTGAEDGDIIFFAADRAKVVNDSLGALRLKIGHSEFGKANGLVQAGWKPLWVVDFPMFEYDDEDARYVAAHHPFTSPKDEHLEYLETDPGRCLAKAYDMVLNGWEIGGGSVRIHREEVQSKVFRALKIGAEEAQLKFGFLLDALQYGAPPHGGIAFGLDRIVTMMAGADSIRDVIAFPKTQRAQDLLTQAPSPVDERQLRELHIRLRQPEQPKA
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_STAA3
Sequence: MAVPKRRTSKTRKNKRRTHFKISVPGMTECPNCGEYKLSHRVCKNCGSYNGEEVAAK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: SHO1_YEASA
Sequence: MSISSKIRPTPRKPSRMATDHSFKMKNFYADPFAISSISLAIVSWVIAIGGSISSASTNESFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAFVYNTNSATNLVYADGPKKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGIRPSPLENSLHRARRRGNRNTTPYQNNVYNDAIRDSGYATQFDGYPQQQPSHTNYVSSTALAGFENTQPNTSEAVNLHLNTLQQRINSASNAKETNDNSNNQTNTNIGNTFDTDFSNGNTETTMGDTLGLYSDIGDDNFIYKAKALYPYDADDDDAYEISFEQNEILQVSDIEGRWWKARRANGETGIIPSNYVQLIDGPEEMHR
What is the function of this protein?
Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.  Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane.  PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures.  Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress.  Involved in the regulation of the mating pathway.  May be a receptor that feeds into the pseudohyphal growth pathway (By similarity).
What are the official names of this protein?
High osmolarity signaling protein SHO1, Osmosensor SHO1, Suppressor of SUA8-1 mutation, Synthetic high osmolarity-sensitive protein 1.
What is the protein family that this protein belongs to?
Belongs to the SHO1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bud. Bud neck. Cell projection. Note=Localizes at the tip of the mating projection during conjugation.
Protein: CUP6H_CORGL
Sequence: MRKTITVIAVLIVLALIGVGIVQYVNTSDDSDFIGQPGEPTGTETTEPPVQPDWCPAVEVIAAPGTWESAANDDPINPTANPLSFMLSITQPLQERYSADDVKVWTLPYTAQFRNINSQNEMSYDDSRNEGTAKMNEELINTHNECPATEFIIVGFSQGAVIAGDVAAQIGSEQGVIPADSVRGVALIADGRREPGVGQFPGTFVDGIGAEVTLQPLNLLVQPIVPGATMRGGRAGGFGVLNDRVQDICAPNDAICDAPVNVGNALDRALAMVSANGVHALYATNPDVFPGTTTNAWVVDWATNLIDNG
What is the function of this protein?
Esterase that may be involved in cell wall biosynthesis and/or maintenance.  Hydrolyzes pNP-butyrate (C4).
What are the official names of this protein?
Carboxylesterase Culp6 homolog.
What is the protein family that this protein belongs to?
Belongs to the cutinase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: RPOB_VIBC3
Sequence: MVYSYTEKKRIRKDFGTRPQVLDIPYLLSIQLDSFEKFIEQDPEGQYGLEAAFRSVFPIQSYNGNSELQYVSYRLGEPVFDVKECQIRGVTYSKPLRVKLRLVIFDKDAPAGTVKDIKEQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYRGSWLDFEFDPKDNLYVRIDRRRKLPASIILRVLGKTSAEILDIFFEKVNFEVKDQTLMMELVPERLRGETATFDIEADGKVYVEKGRRVTARHIRQLEKDGVNFIEVPVEYIVGKVSAKDYVNEATGELIITANQEISLEALANLSQAGYKKLEVLFTNDLDHGPFMSETLRVDSTTDRISALVEIYRMMRPGEPPTKEAAESLFESLFFSAERYDLSTVGRMKFNSSIGREDAEEQGTLDEVDIIEVMKKLISIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDNVMPQDLINAKPISAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRISALGPGGLTRERAGFEVRDVHVTHYGRLCPIETPEGPNIGLINSLSAFARCNEYGFLETPYRRVVNGVVTDEVDYLSAIEEGQFVIAQANAKLTEEGGFADELVTARQKGESGLHPREHVDYMDVATNQVVSIAASLIPFLEHDDANRALMGANMQRQAVPTLRSEKPLVGTGIERNVAVDSGVTAVAKRGGVIQSVDASRIVVKVNEEELIPGEAGIDIYNLTKYTRSNQNTCINQRPCVMPGEPVARGDVLADGPSTDLGELALGQNMRIAFMPWNGYNFEDSILVSERVVQDDRFTTIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVKGGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVPNSVAGTVIDVQVFTRDGVEKDKRALEIEQMQLKEAKKDLTEEFQILEGGLLARVRSVLLAGGYTEAKLSSIERKKWLEQTLENEELQNQLEQLAEQYDELKADFDKKFEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPVEDMPYDENGQPVDIVLNPLGVPSRMNIGQILEVHLGLAAKGIGDKINQMIKEQQELAKLREFLQKVYDLGDTRQRVDISELSDEDVRTLAHNLRAGLPVATPVFDGAPESSIKAMLELADLPASGQLTLFDGRTGDAFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHAMEPGMPESFNVLLKEIRSLGINIELEDE
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: MURI_NOSS1
Sequence: MYSSSSIEGNLYGFSAQEPQRAPIGVFDSGVGGLTVLRQIYRQLPNESVIYFGDTARLPYGIRSQAEILTFVRDILDWMQQQHVKMVVMACNTSSALALDIVREEYDFPILGVILPGAKAAVQQGKRIGVISTPATAKSNAYRQAIWEIDPNVEVWQVGCPEFVPLIEQNRIQDPYTTEVARAYLEPLIQQDIDTLVYGCTHYPLLAPVLRSLLPPQVKIIDPAVHVVTACTQELDLLGLSNTHPPLPTRFAVSGCPQQFSQSGVHWLGYTPLVEAVDFAGVPVSQLQQDLA
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: AHPD_CAUVC
Sequence: MSIEALRARLPDYAHDLGTNLALLVDDPALDPEARWGCFVASACAVGEPQTLRAIDAAATAAGLTAEANRAARKAAAMMAMTNVYFRAVHLMEGAAYQALPCRLRLNRLAHAGARGVTYDLSCVAVSAINGCGACLDSHEADLRGRGVEPTQIQAALRIAAVVSAVARTLAAEAALHPQNLEI
What is the function of this protein?
Antioxidant protein with alkyl hydroperoxidase activity.  Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
What are the official names of this protein?
Alkyl hydroperoxide reductase AhpD, Alkylhydroperoxidase AhpD.
What is the protein family that this protein belongs to?
Belongs to the AhpD family.
Protein: LEU1_BIFLS
Sequence: MGQDQSSVFDLAAVAAASNGGNNDPLLPPARFIGDPQKPSRMPYNKYASYSEQIPFDYPERTWPGKRLQRAPRWCSVDLRDGNQALVNPMDSERKLRFWNLLVSMGFKEIEVGFPSASETDFDFIRMLIERELIPDDVTIVVLTQCREHLIRRTYEALKGAKRAIVHFYNSVSVLQREVVFRKNKEEIKKLATDAAELCKDLENEAKGIDLYYEYSPESFTGTEPEYAVEVCNAVIGVIKPTPEHPMIINLPATVEMTTPNVFADEVEYVSTHLDDRDSVVLSLHPHNDEGMGVAATELAVLAGADRVEGCLLGNGERTGNVDLVTLGLNWLTQGIDPQLDLSNVPEIRKTVEYCNQIKISERHPYAGNFVFTAFSGSHQDAIKKGLEARQVAAERAGADLDSFVWLVPYLPIDPKDIGRTYEAIIRVNSQSGKGGMAYLLKTNHNLDLPKRLQIEFDKIVQNYADTTKKEVKDGDIWRLFKDEYLPVEQSGMTAAGVVVGDTHDASLEPWGRLKLLKVAVSSGEDGSDTVLKARLLDRGVNVGDDEPVEREASGIGNGPIAAFLNAISNFGVEASIMDYVEHTMSVGTDAMAASYVECQIGEADDAQIVWGVGIDSSITTSALKAIISAINRSQRQR
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: HSP72_MOUSE
Sequence: MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAYLGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGGSSGGPTIEEVD
What is the function of this protein?
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes.  Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation.  This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones.  The affinity for polypeptides is regulated by its nucleotide bound state.  In the ATP-bound form, it has a low affinity for substrate proteins.  However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins.  It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (By similarity).  Plays a role in spermatogenesis (PubMed:24557841).  In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841).
What are the official names of this protein?
Heat shock-related 70 kDa protein 2, Heat shock protein 70.2.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with SHCBP1L at spindle during the meiosis process (PubMed:24557841).
Protein: SYH_WOLPP
Sequence: MTNQTVRGTKDLLFDEWYKFKHIEQTASRISSLYGFLPVQTPIFEYTEVFTKTLGDSSDIITKEMYTFIDKGGKSITLRPEFTAAIVRLLIEKKLQAPIKLFSIGPAFRYERPQKGRQRQFHQINFEVFGIEDPKADIELISLAQHLLTEFGINKNVKLEINSLGDSETITQYREALISYLKKFQNDLSEDSQNRLIKNPLRILDSKDKTDKEIISDAPKISDYYTKESSYFFDQVLNGLQALGIPYTVNSKLVRGLDYYCHTVFEFVTEDLGAQGAVFAGGRYDNLVSSVGGKHTPAIGFAGGIERIMELINYAEKKERPIYIIPIGGEAEEHALTLASELRRNGLYVIYEYSGTLKTRMKKANQANAKVVLIFGDEELSSKTLKIKNMDTGEEKMIARDKTVENI
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIN_RHIME
Sequence: MAPKKAAPIAEPAVFAADAELDQAIDDLRGVLKKDGAADFGADFAAAGPLEQPMDFGSDFGSTDGAGFGGDFAAGFGGGLTETGAAGGFDAGSGFVGGDFDAAPIVGETAPGSGMTANMDLIMDIPIDVQIVLGTSRMQVSGLMALTEGATIALDRKIGEPVEIMVNGRVIGRGEITVLEGDVTRFGVKLLEIKGTKK
What is the function of this protein?
FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body.  This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).
What are the official names of this protein?
Flagellar motor switch protein FliN.
What is the protein family that this protein belongs to?
Belongs to the FliN/MopA/SpaO family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body.
Protein: MURG_POLSJ
Sequence: MSEHVRSAGPPQASTAPSGGSAVHEVTSVGARVALVMAGGTGGHIFPGLAVAEALRERGWRVHWLGGRGNAGHPSMESQLVPPRGFAFESIDFSGVRGKGPLTLVFLPLRLLKAFWQSIQVVRRVKPDVVVGLGGYIAFPAGMMSVLLGKPLVLHEQNSVAGMVNKVLAGVADRVFTAFPGVFRKAEWIGNPLRPAFIRQPDPATRFAGRAGPLKLLVVGGSLGAKALNELVPRALALMPPAQRPDVTHQSGIRQIDELRANYAAAGVQAELTPFIEDTAQAFADADLIICRAGASTVTEIAAVGAAALFVPFPSAVDDHQTTNARFLVDQGGGWLLQQRDMSAAALADMLQKTDRSALLQCALKAKTMQKTDATTRVVAACEELAR
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: MR1BB_DANRE
Sequence: MPENIAFLTNSTDLGHVGRALGSSARPAWAIAVLASVLIFTTVVDVLGNLLVIISVFRNRKLRNAGNVFVVSLAFADLVVAFYPYPLVLYAIFHDGWSLGETQCKISGFLMGLSVIGSVFNITGIAINRYCYICHSFAYGRLYSFRNTLLLVALIWALTVLAILPNFFVGSLSYDPRVYSCTFTQTASSSYTVVVVVVHFLVPIAVVTFCYLRIWVLVIQVRRKVKSEERSRVRPSDLRNFVTMFVVFVLFAICWAPLNLIGLVVAINPEVMAPRVPEWLFVVSYFMAYFNSCLNAIIYGLLNRNFRKEYVRIMTAVWIPRRFVTETSRAATDGMRSKPSPAINNNE
What is the function of this protein?
High affinity receptor for melatonin.  The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity).
What are the official names of this protein?
Melatonin receptor type 1B-B, Mel-1B-R-B, Mel1b receptor B, Melatonin receptor Mel1b Z2.6-4, zMel1b-1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.