PharMolix/UniProtQA huggingface dataset:
Protein: ENTP8_BOVIN
Sequence: MGLTWKQRVFTALLGAAAVSGLTALLLVLVGTMNVLLPPDTKFGIVFDAGSSHTSLFVYQWPANKENDTGIVSQALACQAEGPGISSYASNPARVGESLQGCLEEALALIPKAKHHETPMFLGATAGMRLLSRKNRSQAEDVFAAVSRALGQSPVDFRGAELLTGQDEGAFGWITINYILGLLVKYSFSGEWIRPLEETLVGALDMGGASTQITFVPGGPILDKTAQATFRLYGADHTVYTHSYLCFGRDQALSRVLAELVQASTGLLIRHPCYHSGYRGTLALASLYESPCAPAAPPDLSQNLTVEGTGNPGACVEALRKLFNFSSCDGREDCAFAGVYQPPVQGQFYAFSNFYYTFNFLNLTSKPSLSGANATIWEFCLRPWKLVEASAPPGQDRWLRDYCASGLYILTLLVEGYGFSEETWGGIEFRQQAGGADIGWTLGYMLNLTNLIPAEAPAQGWAQSFGVWAAGVVFVVLTLAATLGAVAVQVFWLQD
What is the function of this protein?
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity.  Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides.  Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity).
What are the official names of this protein?
Ectonucleoside triphosphate diphosphohydrolase 8, E-NTPDase 8, NTPDase 8, NTPDase8.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SECA1_RHOBA
Sequence: MSILERLWDLLGLVFGSTFERVGSLATSVFGSANARQVAKLQESADRITAMEPKFAAMSDEELRDQTVLFRKRLREGETLDDIMEEAFAVCREGGKRFLGMRHYDVQLIGGMVLHSGAIGEMVTGEGKTLVATLPAYLNALEAKGVHVITVNDYLARRDMEWMAPLYMNLGLTVDAIQSGMSTSEKQAAYQCDITYGTNNEFGFDYLRDNMRPAAKGDDRFPSEVQQCQGPLNYAIIDEVDNILIDEARTPLIISGPADLDLGRYGEADRVARQLKKEEHFTVDEKQHNVTLTDEGVRAAEELAGVESFYTAGNMEWPHLIDNALKAHYLYKLDVNYVVKDKQVVIVDEFTGRLMDGRQWSDGLHQAVEAKEGVPIKQETQTFATASLQNIFKMYKKLSGMTGTAMTEADEFWKIYKLDVVAIPTHRGLQRIEHPDLIYLTEKDKFKAIADDVERTHKWDVVVLKDGTEIWGNIKSETDSVVELLPKGEKQTESFSHEKIVAIERAGRPVLVGTVSIEKSERLSALLERRGIKHDVLNAKQHGREADIVSQAGRIGAVTIATNMAGRGTDIILGGNPETLAWSQLQHKYPTRLEVPDAEWKALVDEIDERENMSAEGKIVREIGGLYVLGTERHESRRIDLQLRGRCGRQGDPGGSRFFLSLEDDLMRIFAGDFVKSMMERMGMKEGEAIESSLVTRRIAAAQKKVEERNFEIRKSLLEYDEVMDEQRKRVYRYRQNLLDGHSSREMLLTLIHNEIQSQVETFLDPNYGVDTFSTFAGGKLGCQLDARDFQNMDFEMADTYAKDQAERASEVTVAEAVEENLPESMEDEWNWKAMATWANTHLGTNYQDHQLKNKDREEMIDELIAHAHKQIEETDLSEGEPLLEADYGLRVLCAWMRHKFGIETTPEEFRDVEDRRKVTEELNRRAEAAYTEKEAEYPVLTGISRFTDKQGAQVSLDREGLVDWVHGRFNHELSVDEVKLNRDDLKVQLIQYSKQTASASGGMHAQAAEKVEDLFGRADADVTASLASGQSGKLEALATWLQEELGNRNTAEDLSRMNRAELTLAVNGAVDDKFHPEMRRMERQILLNIVDDSWKNHLLTMDHLRSSVGLKGYAQMDPKVEYKREGMRLFESMWDSIGERVTDLIFRMESFNDDFIRSTWVDARTRHDDAHEAGRSAQQAAQMESNTAAQRAAAGSEGRAEGSVDTVRVEEPRIGRNAPCPCGSGKKYKSCCMRRDG
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA 1.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: RUVA_CROS8
Sequence: MIGRLRGIVLEKQPPLVLLEAGGVGYEVHMPMTCFYELPETGKEAVVFTHFVVREDAQLLFGFNNKQERTLFRELIKVNGVGPKLALAILSGMSAQQFVNAVEREEPAALVKLPGIGKKTAERLVVEMKDRFKGLHGDLFTPAADLVLTSPASPAVDDAEAEAVAALVSLGYKPQEASRMVSKVAQADASSETLIREALRAAL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: CBBX_GUITH
Sequence: MIAFISNYITFKTNRTYKNNICQLHCQSLNDNDIEARKIKEEAERRKQQAERNRMQKQMKIDRLNAIPEDAEAGTVEEFMYKDGVKEILEKLDNDLVGLVPVKSRVREIAALLVVDKLRRNLGLDTSVPSLHMCFTGAPGTGKTTVAMRMGQILQRMGYCRSGHLVVATRDDLVGQYVGHTAPKTKEVIKKAMGGVLLIDEAYYLYNASNDRDYGQESIEILLNVMEENREDLVVVLAGYKDRMDKFFSFIPGMSSRVGNHIEFPNYEAEELLSIAKVMCRDLEYEMSKDAEPIFFEYIKKRMTMPYFSNARTVRNAVDRARMRAAIRLFNQATSGNSNGLVSKKQLMTLEKEDFVSVEELIARGDNAIVE
What is the function of this protein?
Seems to be necessary for the expression of RuBisCO.
What are the official names of this protein?
Protein cbbX homolog, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the CbxX/CfxQ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: IHFA_COLP3
Sequence: MALTKAEVAEHLFEKVGLSKRDAKDMVEIFFEEIRETLESGDQVKLSGFGNFDLRLKSERPGRNPKTGEDIPISARKVVTFRPGQKLKSRVEDGNSD
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit alpha, IHF-alpha.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: FTHS_NEIG1
Sequence: MSFKTDAETAQSSTMRPIGEIAAKLGLNVDNIEPYGHYKAKINPAEAFKLPQKQGRLILVTAINPTPAGEGKTTVTIGLADALRHIGKDSVIALREPSLGPVFGVKGGAAGGGYAQVLPMEDINLHFTGDFHAIGAANNLLAAMLDNHIYQGNELNIDPKRVLWRRVVDMNDRQLRNIIDGMGKPVDGVMRPDGFDITVASEVMAVFCLAKDISDLKERFGNILVAYAKDGSPVYAKDLKAHGAMAALLKDAIKPNLVQTIEGTPAFVHGGPFANIAHGCNSVTATRLAKHLADYAVTEAGFGADLGAEKFCDIKCRLAGLKPDAAVVVATVRALKYNGGVERANLGEENLEALAKGLPNLLKHISNLKNVFGLPVVVALNRFVSDSDAELAMIEKACAEHGVEVSLTEVWGKGGAGGADLARKVVNAIDNQPNNFGFAYDVELGIKDKIRAIAQKVYGAEDVDFSAEASAEIASLEKLGLDKMPICMAKTQYSLSDNAKLLGCPEGFRIAVRGITVSAGAGFIVALCGNMMKMPGLPKVPAAEKIDVDEHGVIHGLF
What are the official names of this protein?
Formate--tetrahydrofolate ligase, Formyltetrahydrofolate synthetase, FHS, FTHFS.
What is the protein family that this protein belongs to?
Belongs to the formate--tetrahydrofolate ligase family.
Protein: SYP_BACC3
Sequence: MKQSMVFSPTLREVPADAEIKSHQLLLRAGFMRQNASGIYSFLPFGLKVLHKVERIVREEMERAGAVELLMPAMQAAELWQESGRWYSYGSELMRMKDRNAREFALGATHEEVITDLVRDEVKSYKKLPLTLYQIQTKFRDEQRPRFGLLRGREFLMKDAYSFHATQESLDEVYDRLYKAYSNIFARCGLNFRAVIADSGAMGGKDTHEFMVLSDVGEDTIAYSDTSDYAANIEMAPVVATYTKSDEAEKELEKVATPDQKAIEEVSAFLNIEADKCIKSMVFKVDEKLVVVLVRGDHEVNDVKVKNVYGASVVELASHEEVKELLNCEVGSLGPIGVNGDIEIIADHAVASIVNGCSGANEEGFHYVNVNPERDFKVSQYTDLRFIQEGDQSPDGNGTILFARGIEVGHVFKLGTRYSEAMNATFLDENGKTQPLIMGCYGIGVSRTVAAIAEQFNDENGLVWPKAVAPFHVHVIPVNMKSDAQREMGENIYNSLQEQGYEVLLDDRAERAGVKFADADLFGLPVRVTVGKKADEGIVEVKVRATGESEEVKVEELQTYIANILK
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK20_ACOCL
Sequence: MTRVRRGYIARRRRTKIRLFAATFRGAHSRLTRAATQQKMRALVSAHRDRGKQKRDFRRLWITRINAVTRENGVCYSYSRLMHNLYKRQLLLNRKILAQIAILNKNCLHIISNEIIK
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MUT7_DROME
Sequence: MARKSHMYNAIPAGFESDEENMENLMSNLKIKRLEDITTGAGIDGCNFDATLDAKAEEFFKLFREKWNMYSKKKSPHLRQEFGRALMGHQDPLLLALKIFANCPDSSNIKTKSLSHFVLDTVCKLHKDFPHLGEGCDPNTSMIAFNFVKTSGLLALNNAVIHAYSLRQIRDLLLPKLRELLDNGLYKEVTQWSISLQLTHEFDMLELAFPLIAIEKLPLAEEYLDHATQQRLPFVKFLDSLLHKEKSVLELCEHLLDRYKNLKISHNVLSYRPMAKIVARLAKKYGFDDAVTPNYKFTKTCSYLHYLYREYEKTRMNLASFREVVSVHAFNHELRTDFVKYLASAGAHSEAIYWYTEFNIDPKDCPLEIETQVSQNGAGKASGWESPGKERCPSSRCDMYLTMDLPDECLIIVNKADEFDRMLYHLQQECVIYLDSEWMQSVCGDNQLCVLQIATGHNVYLIDCLARESLRSEHWRLLGANIFNNVNIRKVGFSMVSDLSVLQRSLPLQLRLQMPHHYLDLRNLWLELKKQRFGVELPFGNVNRAGDALTDLSLACLGKKLNKSNQCSNWANRPLRREQILYAAIDARCLMLIYNTLIERVSFIQAVIEKSIASNNFLRRGAHVK
What is the function of this protein?
Possesses 3'-5' exoribonuclease activity.  Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation.
What are the official names of this protein?
Exonuclease mut-7 homolog, Exonuclease 3'-5' domain-containing protein 3 homolog, Protein nibbler.
What is the protein family that this protein belongs to?
Belongs to the mut-7 family.
Protein: RECG_PASMU
Sequence: MTIQFLDAVPLTTLSGVGAAISDKLGRIGIHNLQDLLFHLPIRYEDRTRITPIHDLRPDAYATIEGLVQTCEVQFGKRPILNVSLSDGTSKIMLRFFNFNAGMKNSLQPGARVKAFGEVKRGRFMAEIHHPEYQIIRDNAPLILEETLTPIYSTTEGIKQNSLRKLTDQALAVLENIQIAEILPNEFNPHPFSLKEAIRFLHRPPPDVSLEALEKGTHPAQQRLIFEELLAHNLAMQKVRIGTQQFSAYPLSYQTDLKQRFLAQLPFTPTDAQVRVTQEIEQDLTHPFPMMRLVQGDVGSGKTLVAALAALLAIDNGKQVALMAPTEILAEQHATNFRRWFESLGIEVGWLAGKVKGKARQTELEKIRTGQVQMVVGTHALFQDEVEFSDLALVIVDEQHRFGVHQRLMLREKGKQADHYPHQLIMTATPIPRTLAMTVYADLDTSIIDELPPGRTPITTVAISEERRAEVIARVNHACVNEKRQAYWVCTLIDESEVLEAQAAEAIAEDLRKILPHLRIGLVHGRMKPAEKQDIMQAFKQAEIDLLVATTVIEVGVDVPNASLMIIENAERLGLSQLHQLRGRVGRGTTASFCVLMYKPPLGKISQKRLQVLRDTQDGFVISEKDLEIRGPGEVLGTKQTGVAEFKVANLMRDRKMIPTVQYYARRLIVEQPEVATKLIQRWINQREIYTHV
What is the function of this protein?
Critical role in recombination and DNA repair.  Helps process Holliday junction intermediates to mature products by catalyzing branch migration.  Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity.  Unwinds branched duplex DNA (Y-DNA) (By similarity).
What are the official names of this protein?
ATP-dependent DNA helicase RecG.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecG subfamily.
Protein: DHX15_HUMAN
Sequence: MSKRHRLDLGEDYPSGKKRAGTDGKDRDRDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHAGHAGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDRIIAKLQSKEYSQY
What is the function of this protein?
RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19432882, PubMed:19103666, PubMed:32179686, PubMed:24990078, PubMed:24782566, PubMed:34161762).  Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666).  In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666).  Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24990078, PubMed:24782566, PubMed:34161762).  Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24990078, PubMed:24782566, PubMed:34161762).  Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762).  The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762).  Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase DHX15, ATP-dependent RNA helicase #46, DEAH box protein 15, Splicing factor Prp43, hPrp43.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.
What are the subcellular locations of this protein?
Nucleus. Nucleus, nucleolus.
Protein: SOTB_HAEIG
Sequence: MPLYLKAEKIQSWRVLIMACAGFIFNTTEFVPVAMLSDIAQSFDMQTADTGLMMTVYAWTVLIMSLPAMLATGNMERKSLLIKLFIIFIVGHILSVIAWNFWILLLARMCIALAHSVFWSITASLVMRISPKHKKTQALGMLAIGTALATILGLPIGRIVGQLVGWRVTFGIIAVLALSIMFLIIRLLPNLPSKNAGSIASLPLLAKRPLLLWLYVTTAIVISAHFTAYTYIEPFMIDVGHLDPNFATAVLLVFGFSGIAASLLFNRLYRFAPTKFIVVSMSLLMFSLLLLLFSTETIIAMFSLVFIWGIGISCIGLSLQMRVLKLAPDATDVATAIYSGIFNAGIGAGALFGNLATTYLGLNEIGYTGAALGLIGFIIFITTHLKYRHTFLLQNK
What is the function of this protein?
Involved in the efflux of sugars.  The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites.
What are the official names of this protein?
Probable sugar efflux transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL29_THET2
Sequence: MKLSEVRKQLEEARKLSPVELEKLVREKKRELMELRFQASIGQLSQNHKIRDLKRQIARLLTVLNEKRRQNA
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: MATK_NYPFR
Sequence: MEELQGYLERDRFRKQHFLYPLLFKEYIYTFAHDRGLNGSIFYESAEIFGYDNKSSSVLVKRLIIRMYQQNYLIYSVNDSNQNRFVGHNNYLYFHFYSQMILEVFTVIVEIPFLLRLVSSLERKIPKSQNLNLRSIHSIFPFLHEYPNWNSLITPNNSIFLFSKENKRLFRFLHNSYVSECEFVLVFLRKQSSYLRLTSSGAFLERTHFYGKIEHLHLIVVRRNYFQKTLWFFKDPFMHYVRYQGKAILVSKGTHLLMKKWKCHLVNFWQYYFHFWSQPYRIHINQLSNCSFYFLGYLSSVLINPSVVRNQMLENSYLIDTVTKXFDTRVPVISFIGSLAKAKFCTVSGHPISKPIWTDLSDCDIIDRFGRICRNLSNYLSGSSKKQSLYRIKYILRFSCARTLARKHKSMVRAFLQRLGSGLLEEFFTEEEQVVSLIFPKANSFSLHGSHRERIWYLDITCINDLVNYS
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL35_DEHM1
Sequence: MPKMKTRKTAAKRFHVTGTGKIMRSKGMKSHLRRNKSARVRRQFDEMSQVAGVDRARIQKLIPYGVS
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: KCNH1_HUMAN
Sequence: MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS
What is the function of this protein?
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660).  Channel properties are modulated by subunit assembly (PubMed:11943152).  Mediates IK(NI) current in myoblasts (PubMed:9738473).  Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642).
What are the official names of this protein?
Potassium voltage-gated channel subfamily H member 1, Ether-a-go-go potassium channel 1, EAG channel 1, h-eag, hEAG1, Voltage-gated potassium channel subunit Kv10.1.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Presynaptic cell membrane. Perikaryon. Postsynaptic density membrane. Early endosome membrane. Note=Perinuclear KCNH1 is located to NPC-free islands.
Protein: PRS30_RAT
Sequence: MESWARCIFLLLLQILTGGRGDILHSGAGKIVGGQDAPEGRWPWQVSLRTEKEGHICGGSLIHEVWVLTAAHCFRRPLNSSFYHVKVGGLTLSLTEPHSTLVAVRNIFVYPTYLWEDASSGDIALLRLDTPLQPSQFSPVCLPQAQAPLTPGTVCWVTGWGATHERELASVLQELAVPLLDSEDCERMYHIGETSLSGKRVIQSDMLCAGFVEGQKDSCQGDSGGPLVCAINSSWIQVGITSWGIGCARPNKPGVYTRVPDYVDWIQRTLAENHSDAYGCRSRASGAYPALLLVLLAFALPESL
What is the function of this protein?
Selectively cleaves synthetic peptide substrates of trypsin.  Activates the epithelial sodium channel ENaC.
What are the official names of this protein?
Serine protease 30, Distal intestinal serine protease, Transmembrane serine protease 1, TMSP-1, Transmembrane serine protease 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: MIAB_BORPD
Sequence: MQETSIKRAGASAAASAAPAATVPATASASARKLYIRTFGCQMNEYDSDKMADVLRGDQGLELTDNPEDADVILFNTCSVREKAQEKVFSDLGRVQHLKKLNPDLVIGVGGCVASQEGEAIVKRAPYVDVVFGPQTLHRLPELIRRRRASGASQVDISFPEIEKFDALPPPRIEGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPFDDVLVEVADLADQGVKEVTLLGQNVNAYRGPMGDTGEIADFATLLEYVHEIPGIERIRYTTSHPKEMTQRMVDAYANLPKLVSFLHLPVQAGSDRVLAAMKRGYTTLEFKSVVRRLRAARPGLTLSSDFIVGFPGETEEDFDKTMKLIEDVGFDTSFSFIYSRRPGTPAADLVDDTPQEVKLRRLQQLQALINAQAAAIAQAMVGTRQRLLVEGPSRRDPNELMGRTENNRIVNFPAPARLIGQMVDVIITDAYPNSLRARVADVDGLAQGNA
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF4A2_MACFA
Sequence: MSGGSADYNSREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADGMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
Eukaryotic initiation factor 4A-II, eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: TTCA_GEOUR
Sequence: MALIEDRLFTRIKNRVGRAIADYNLIEEGDRIAVAVSGGKDSYTLLHILETLRKRAPVRYEIMAINIDSGYPGFRADIIEEHLREHGFVAHMEKTDHYGIIKEKRRPDSSYCSICARLKRGVLYGLAQRYNCNKLALGHHMDDFIETLLLNQFFVGSLKAMAPSMLADNGLTTVIRPLVYVPEEDIIPFSRNNRFPVLCCCCPVCGSADQQRKRMKELLKTLEKENPFVKKSLLKALANVQPRYLLDRRVKY
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_COXB2
Sequence: MSLKIVFAGTPQFAVPTLRALIDSSHRVLAVYTQPDRPSGRGQKIMESPVKEIARQNEIPIIQPFSLRDEVEQEKLIAMNADVMVVVAYGLILPKKALNAFRLGCVNVHASLLPRWRGAAPIQRAILAGDRETGISIMQMNEGLDTGDVLAKSACVISSEDTAADLHDRLSLIGADLLLESLAKLEKGDIKLEKQDEASATYASKIQKQEALIDWRKSAVEIARQVRAFNPTPIAFTYFEGQPMRIWRATVVDEKTDFEPGVLVDADKKGISIAAGSGILRLHQLQLPGKRVCSAGDFINAHGDKLIPGKTVFG
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: PRVB1_MERGA
Sequence: AFAGILADADITAALAACKAEGTFKHGEFFTKIGLKGKSAADIKKVFGIIDQDKSDFVEEDELKLFLQNFSAGARALTDAETATFLKAGDSDGDGKIGVDEFAAMVKG
What is the function of this protein?
In muscle, parvalbumin is thought to be involved in relaxation after contraction.  It binds two calcium ions (By similarity).
What are the official names of this protein?
Parvalbumin beta 1.
What is the protein family that this protein belongs to?
Belongs to the parvalbumin family.
Protein: PSF3_CRYNB
Sequence: MEDDYFSITSILADNHKMSCTFALDAEGLGYLEGSTENDIHEGTKVELPFWLAQTLSVNQFTTFTLPLPYSSRVQSALVASPVSVKLSNLVGGNGWWYRWGKKLADMLEDEQATNIRNMLLRAFTGRLPTLQDLAAHHASADHTMPELSTSKAEMFRDGMEGDERELFSIGQDSGRLFKAWYDRKKGSR
What is the function of this protein?
The GINS complex plays an essential role in the initiation of DNA replication.
What are the official names of this protein?
DNA replication complex GINS protein PSF3.
What is the protein family that this protein belongs to?
Belongs to the GINS3/PSF3 family.
What are the subcellular locations of this protein?
Nucleus.