PharMolix/UniProtQA huggingface dataset:
Protein: VENT1_XENLA
Sequence: MVQQGFSIDLILARSKEEATDGKDSMSSRPHIPCAPQPLPPTKYAKEMPRKKDGQDVQEHTTSFQCSLGEQVINRPSANPSLAAMHRSSGSSDEFSPPGSEDDSTESSGRSSQENDTEQREKSPKSDLQRRLRTAFTPQQISKLEQAFNKQRYLGAPERKKLATSLQLSEIQVKTWFQNRRMKLKRQIQDKQHSLVPPPVCYPQTFPYYPGGFPVPLNSGSFYQPRALPFQAPQHSYIPQPLHHHVRMSSHQEQYPPLFGAQYM
What is the function of this protein?
Transcriptional repressor.  Cooperates with vent2 in a ventral signaling pathway downstream of bmp4, which antagonizes the Spemann organizer and dorsal mesoderm formation, and leads to ventral mesoderm formation.  Acts downstream of bmp4 to repress transcription of foxa4-B/XFD-1'.  Binds to DNA with preference for the target sequence 5'-CTATT[T/C]G-3'.  Also binds 5'-TGCATTTTG-3' at a lower frequency, and occasionally 5'-TTGATC-3'.  Binds to the homeobox 2 (HBX2) repressor element in the promoter of the myf5 gene and represses myf5 transcription in the ventral domain.
What are the official names of this protein?
Homeobox protein vent1, Xvent-1.
What are the subcellular locations of this protein?
Nucleus.
Protein: STR3_STRTC
Sequence: MSSPAAQTPYALVPTDAEWERLDAQHNGIAKFLDHKLAPVDLGQPKKILEIGSGSGAWAIQAAKQFPDADVLAVDQNPLPARPLPSNIRFQQLNVLEPFPFPPGSFDIVHIRFVLCHLPNGYTVLPRIIELVAPGGWLLVDDIDFLHAFEGLDKAPGVKSGFTGLIKSMESHDADPHFGKTLKGLLESSSALSEVNVQKVELPINPTPEXPALGPLSRTMRQAFSNAVGAEKLNPDTVTKGGLTREVQQAFLNEMGGDAQDWSYSVHLYFSWSQKRV
What is the function of this protein?
Methyltransferase; part of the gene cluster that mediates the biosynthesis of strobilurin A, an antifungal polyketide that contains a key beta-methoxyacrylate toxophore that targets the complex III of the mitochondrial electron transport chain (PubMed:30258052).  Strobilurin biosynthesis begins with construction of benzoyl CoA by step-wise elimination of ammonia from phenylalanine by the phenylalanine ammonia-lyase str11, oxygenation by str8 and retro-Claisen reaction to form benzoic acid, which is activated to its CoA thiolester benzoyl CoA by the dedicated CoA ligase str10 (PubMed:30258052).  Benzoyl CoA forms the starter unit for the highly reducing polyketide synthase stpks1 that produces the polyketide prestrobilutin A (PubMed:30258052).  The FAD-dependent oxygenase str9 then catalyzes the key oxidative rearrangement responsible for the creation of the beta-methoxyacrylate toxophore (PubMed:30258052).  Str9 performs epoxidation of the 2,3 olefin of prestrobilutin A, followed by Meinwald rearrangement to furnish the aldehyde intermediate (Probable).  Rapid enolization of the aldehyde intermediate would give the beta-methoxyacrylate skeleton and methylations catalyzed by str2 and str3 complete the synthesis and lead to the production of strobilurin A (Probable).  The short-chain dehydrogenase stl2 and the dehydrogenase str4 play a role in the shunt pathway leading to the production of bolineol (PubMed:30258052).  The cluster encodes no obvious halogenase gene that could be involved in production of strobilurin B, nor any obvious dimethylallyl-transferase that could be involved in the production of strobilurin G (Probable).  It is possible that unknown proteins encoded in, or near, the cluster (such as str1 or stl1) may form new classes of halogenases or dimethylally-transferases, or that the responsible genes are located elsewhere on the genome (Probable).  Similarly, proteins encoded by str5/str6 hydrolases appear to have no chemical role in the biosynthesis of strobilurin A (Probable).  Finally, no obvious self-resistance gene is found within the cluster (Probable).
What are the official names of this protein?
Methyltransferase str3, Strobilurin A biosynthesis cluster protein r3.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
Protein: TM144_MOUSE
Sequence: MSSNATDLTTGYLSSAAAILLFGSNFVPLKKYDTGDGMFLQWVLCAAIWLVALVVNLILHCPKFWPFAMLGGCIWATGNIAVVPIIKTIGLGLGILIWGSFNTLTGWASSRFGWFGMDAEEVSKPMLNYVGAGLSVVSALTFLFIKSEIPNNPGSSDTTPLMTEPVINRTEDRSADSSWVDRLSTTYHRIVGCSLAVISGILYGSTFVPIIYIKDHSRRNDSMYAGASQYDLDYVFAHSSGIFLTSTVYFVAYCVAMKNRPKLYPEAVLPGLLSGVLWAIATCCWFIANHSLSAVISFPIITAGPGLIAALWGILIFKEIQGLRNYLLMMLAFCIILAGALCTAFSKV
What are the official names of this protein?
Transmembrane protein 144.
What is the protein family that this protein belongs to?
Belongs to the TMEM144 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: SELTB_DANRE
Sequence: METRCLYLLLVCVLSVNHATADNGSIKKMKMQYTGFPLLKFQICVSUGYRRVFEEYTRVLTQRYPDIRIEGENFLPQPLYRHIASFLSVFKLVVIGLIILGKNPFTYLHIETPGIWLWAQENKIYACTMVFFLSNMIENQCMSTGAFEVTLNDVPVWSKLQSGHLPSMQQLVQILENEMKLSVHMDSLPHRRA
What is the function of this protein?
Selenoprotein with thioredoxin reductase-like oxidoreductase activity.
What are the official names of this protein?
Thioredoxin reductase-like selenoprotein T1b.
What is the protein family that this protein belongs to?
Belongs to the SelWTH family. Selenoprotein T subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane.
Protein: MPK4_LEIME
Sequence: MTQLVPLAELPSGKKIYSVRGQRFEVDRQYDLVKVVGFGACGTVCSAVVNGSGERVAIKRLSRVFGDLREGKRILREMEIMTSLKHNNLIRLHHFMRPQSKETFEDIYLVMDLYDTDLNRIIRSRQKLTDEHLQYFMIQAFRGLHYLHSAKVMHRDLKPSNLLVNADCALAICDFGLARDDQVMSSSDLTQYVVTRWYRPPEVLGMGSNQYTSAVDVWSLGLIFAELMVGRALLPGTDYIGQLVMIVNLLGSPSIDDMEFLSSEAKAFILSQPHRPALSFRDLFPMATEEATDLLSKLLVFHPARRLTAKQVMEHPYFSKYRDAAEEADAPDPFVWNHSHIETKEQLREDLWRVVEAHSQLNE
What is the function of this protein?
Essential for the two main proliferating life stages, the promastigotes and amastigotes, of the parasite.
What are the official names of this protein?
Mitogen-activated protein kinase 4, LmxMPK4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: SYY1_VIBVU
Sequence: MNSQLLFDDLAQRGLIAQTTDLEQLIALFRQPQTLYCGFDPTAGSLHIGHLVPLIMLKRFQDAGHQGIALIGGATGMIGDPSFKASERSLNSAETVAAWVNALATQIQQLMTPHLTQPLVMVNNADWMQSIGVIAFFRDIGKHFSVNAMIQRESVKQRLARPDQGISFTEFSYSLLQSYDFAQLNQTHQCALQIGGNDQWGNIVSGIDLTRRLNGTNVHGLTLPLITKSDGTKFGKTEGGAIWLDAAKTSPYMFYQFWLNCDDADVYRFLRYYTFLSVEQIEQLEATDKAQVGKPSAQRILAEEMTRFVHGQAGLESAQRISQALFSGQLNQLNLAELKQLEQDGLPCRQLAHVSDVVTLLLETGLASSKRQAREWLENGAIRINGERWHELTLAQTFALYDQYYIVQRGKKQFAMVKLAQV
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase 1, Tyrosyl-tRNA synthetase 1, TyrRS 1.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MAT2B_BOVIN
Sequence: MVGREKELSIHFVPGDCRLVEEEVNIPNRRVLITGATGLLGRAVYKEFQQNNWHAVGCGFRRARPKFEQVNLLDSNAVHHIIYDFQPHVIVHCAAERRPDVVENHPDAASQLNVDASGNLAKEAAAIGAFLIYISSDYVFDGTNPPYREEDIPNPLNLYGKTKLEGEKAVLENNLGAAVLRIPVLYGEVERLEESAVTIMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVVGAQRPRNAQLDCSRLETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
What is the function of this protein?
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP.  Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.  Can bind NADP (in vitro).
What are the official names of this protein?
Methionine adenosyltransferase 2 subunit beta, Methionine adenosyltransferase II beta, MAT II beta.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
Protein: ENV_SIVV1
Sequence: MTKFLGIFIVLGIGIGIGISTKQQWITVFYGVPVWKNSSVQAFCMTPTTRLWATTNCIPDDHDYTEVPLNITEPFEAWADRNPLVAQAGSNIHLLFEQTLKPCVKLSPLCIKMNCVELKGSATSTPATSTTAGTKLPCVRNKTDSNLQSCNDTIIEKEMNDEAASNCTFAMAGYIRDQKKNYSVVWNDAEIFCKRSTSHNGTKECYMIHCNDSVIKEACDKTYWDELRLRYCAPAGYALLKCNDWDYAGFKPECSNVSVVHCTTLMNTTVTTGLLLNGSYSENRTQIWQKHGVSNDSVLILLNKHYNLTVTCKRPGNKTVLPVTIMAGLVFHSQKYNTRLRQAWCHFQGNWKGAWKEVQEEIVKLPKERYQGTNDTNKIFLQRQFGDPEAANLWFNCQGEFFYCKMDWFLNYLNNLTVDADHNHCKNNAGKGRSPGPCVQRTYVACHIRSVINDWYTISKKTYAPPREGHLQCTSTVTGMTVELNYNNQNRTNVTLSPQIETIWAAELGRYKLVEITPIGFAPTEVRRYTGGQERQKRVPFVLGFLGFLGAAGTAMGAAATALTVQSQHLLAGILQQQKNLLAAVGAQQQMLKLTIWGVKNLNARVTALEKYLADQARLNAWGCAWKQVCHTTVPWTWNNTPEWNNMTWLEWEKQIEGLEGNITKQLEQAREQEEKNLDAYQKLSDWSSFWSWFDFSKWLNILKIGFLAVIGVIGLRLLYTLYTCIARVRQGYSPLSPQIHIHPWKGQPDNAGEPEEGGRTGKSKSTH
What is the function of this protein?
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers.  Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells.  Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells.  This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
What are the official names of this protein?
Envelope glycoprotein gp160, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein gp41]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein. Note=It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag. SUBCELLULAR LOCATION: [Surface protein gp120]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Host endosome membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity).
Protein: SLD2_CANGA
Sequence: MDMDVQQVKLKIKRWEHAFIAEHNRPPDKDDIRPLTEMKQLYKLYSVLKSKERKAEPIQKQQTPRKDSNMVLGPTPQIYGKAVSIFEMKVSPLKVEETPTTEVEEDIESEIESSVNRRNSDEASANEEKLGIHSVKKRLFESPKKTENTTHLAVPQVTRYGPNSPLKLAQTVSIRQHLLTPKKKKAEPKSLYTPSPLLKRNSSKTLYELAHEHLQYVEEIKELDQQFKSEIVPIRHGNGQDIGDESDEVPEKKKRRTGVLRRLQFDEDENDRTIKKDLHKELLKLKSRKVKEFLGKEDNEPSEEEEEEQQKSEPLPVKKKKPKKYNLVSNNFRRLKLPKKNRNPRFGRRR
What is the function of this protein?
Has a role in the initiation of DNA replication.  Required at S-phase checkpoint (By similarity).
What are the official names of this protein?
DNA replication regulator SLD2.
What is the protein family that this protein belongs to?
Belongs to the SLD2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: VM1_BOTPI
Sequence: TYIEVAVVADHRMFKKYNSNLNTIRKWVHEMVNSMNGVYRSMDVHLSLANLEVWSKKDLINVQKDSRETLKSFGEWRERDLLPRISHDNAQLLTAIVFDQQTIGRAYIGGMCDPRHSVGVVMDHSKINLQVAVTMAHELGHNLGMEHDENQCHCDAPSCVMXXXXXXXXXXXXXXCXXXXXXXXXTKHNPQCILNEPL
What is the function of this protein?
Zinc metalloprotease that preferentially degrades Aalpha chain of fibrinogen (FGA) (at a dose of 5 ug, whereas at a dose of 10 ug, both FGA and FGB are completely degraded).  Degrades fibrin gel in a dose-dependent manner, as well blood clots formed in vitro (thrombolytic activity).  Induces hemorrhage (in the dorsal skin of mice), with an MHD of 50 ug.  The basal membrane components collagen (all chains of type IV) (COL4A4), fibronectin (FN1), laminin and nidogen are all degraded by this toxin.
What are the official names of this protein?
Snake venom metalloproteinase BpirMP, SVMP, Alpha-fibrinogenase, Fibrinolytic metalloproteinase, Zinc metalloproteinase.
What is the protein family that this protein belongs to?
Belongs to the venom metalloproteinase (M12B) family. P-I subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CPI2_CAEEL
Sequence: MKAILVFALIAISIISVNAGMMTGGSVEQDASQKEYSDKAWKAVKGINDQASNNGPYYYAPIKVTKASTQVVAGISTKLEVLVGESNCKKGELQAHEITSSNCQIKDGGSRALYQVTIWEKPWENFEQFTVEKIRDVTADEQF
What is the function of this protein?
Cysteine protease inhibitor which inhibits members of the peptidase C1 family (PubMed:12704112, PubMed:15664654).  Does not inhibit asparaginyl endopeptidase (PubMed:15664654).  Required for the uptake and/or processing of yolk proteins during the development of oocytes, probably by regulating the catalytic activity of cysteine proteases cpl-1 and cpz-1 (PubMed:16857685).  May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation (PubMed:24001183).
What are the official names of this protein?
Cystatin cpi-2, Ce-cpi-2a, Cysele2.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cytoplasmic granule. Note=Localizes to the sheath cell cytoplasm surrounding germ cells and oocytes. Localizes to yolk granules in the developing oocyte.
Protein: Y2047_MYCTO
Sequence: MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIRDATAVESAMTGADVVAHCAWVRGRNDHINIDGTANVLKAMAETGTGRIVFTSSGHQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEAPEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAPQPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR
What are the official names of this protein?
Uncharacterized protein MT2107.
What is the protein family that this protein belongs to?
Belongs to the PEP-utilizing enzyme family.
Protein: NU5M_CARSF
Sequence: MNLFSSSILLSLTLLITPFIITTTKKYETHAYPYYVKNSIACAFMTSLVPMLMFLYTNQEMIISNWHWMTIHTMKLCLS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VASN_XENTR
Sequence: MWHLLVWIILLATAQQMITEGCPAGCQCNTPQTVFCLARKNSNFPRSVPPDTLNLYVFENGISSIEESSFIGLNGLHLLDLSHNQLSSLPGGVFRNLANLSNLDLTSNQLTEISADTFQGLSRLERLYLNGNRIRSIHPEAFKGIESLLELKLSNNQLVTPPAFSLPHLLLLDLSYNAIPVIQQGVFNAGNIESLRLAGLGLKEVPEELLSGLKNLHELDLSDNQLDKVPPGLHGLTKLNIAGNVGFSQIQVDDLSNLPALQELDLSGLSLQTLPKGLFRSSKRLRAVSLAQNPFNCVCSLGWLSEWMRVSGVVLLRPDETRCHFPPKNAGKTLRQLRDSEYGCPAPTTIQMPSTMPPSTTTGPPTTTKHLQTEAPTTASTTTTTIPHQEQEEDTQPFQFDFEDTLCPPQTCLNGGSCHLDPTGQLECECPPGFQGTYCETGPVTPAVVTEMYIEQVKIIEVTVSSIRVDLQSYSQNKEKLRAIRLTVRNLYGADRRPMIYKLPPTLPEYTVRALSSNSSYWVCLGSQGEGGPEEDLCTETHTLGEPPKHSPQVTQSQEGNLTLVLVPAVAAGILLSAAVAAAACYARRRKGKGHSVEDGGPLEMDGVKKGLDGKGEVKKLSEDPTGPEKTGAESEEPLMDSTRIGNNNDAPTGRLPHSYF
What is the function of this protein?
May act as an inhibitor of TGF-beta signaling.
What are the official names of this protein?
Vasorin.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RS18_WOLWR
Sequence: MMKRRNSFNNSYVSVNNRTGFRRSKVCPLAASKDEDIDYKNIDLLSKFTSDYGRILPRRLTGVCAKKQRKLRLAIIRARFLALIPYCTKKV
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: FETP_HAEDU
Sequence: MARMVFCEYLKKEAEGLDFQLYPGELGKRIFNSISKQAWAEWIKKQTMLVNEKKLNMMNPEHRQLLEAEMVNFLFEGKDVHIDGYVPVQTNTKA
What is the function of this protein?
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
What are the official names of this protein?
Probable Fe(2+)-trafficking protein.
What is the protein family that this protein belongs to?
Belongs to the Fe(2+)-trafficking protein family.
Protein: CEX1_ASPNA
Sequence: MSSTTSSSRSDLEKVPVPQVTPRDSDSDKGSLSPEPSTLEAQSSEKPPHHIFTRSRKLQMVCIVSLAAIFSPLSSNIYFPALDDVSKSLNISMSLATLTITVYMIVQGLAPSFWGSMSDATGRRPVFIGTFIVYLVANIALAESKNYGELMAFRALQAAGSAATISIGAGVIGDITNSEERGSLVGIFGGVRMLGQGIGPVFGGIFTQYLGYRSIFWFLTIAGGVSLLSILVLLPETLRPIAGNGTVKLNGIHKPFIYTITGQTGVVEGAQPEAKKTKTSWKSVFAPLTFLVEKDVFITLFFGSIVYTVWSMVTSSTTDLFSEVYGLSSLDIGLTFLGNGFGCMSGSYLVGYLMDYNHRLTEREYCEKHGYPAGTRVNLKSHPDFPIEVARMRNTWWVIAIFIVTVALYGVSLRTHLAVPIILQYFIAFCSTGLFTINSALVIDLYPGASASATAVNNLMRCLLGAGGVAIVQPILDALKPDYTFLLLAGITLVMTPLLYVEDRWGPGWRHARERRLKAKANGN
What is the function of this protein?
Transmembrane transporter that exports citrate across the cell membrane.
What are the official names of this protein?
Citrate exporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OPGG_SHESA
Sequence: MVSLLRCQSFKPSSSLICSLALSAAFALSSSAFAEETKPAENKPATPVVSPPKATAQPANKNQVRFTKTGTFDGDSVVKLARKLASKPYVVLKDPLPAGLAKLTYDEYRDIRFNPISSIWRDQGLPFQMQMFHRGFYFQDLIEIAIVEANQATHLAYEPKYFTAGEVITQALPNDDIGYSGFRIHNQLNTNGVYDELMVFQGASYFRALGKGNSYGLSARGLALKTADPEGEEFPIFRAFWVERPSYDSNLIVVHALLDSPSVAGAYRFSVRPGDNTQIDVEATLFPRVELSKVGLAPSTSMFLHSLNGRHDTDDFRPEVHDSDGLLMFNGRGEHLWRPLANPRQLQVSAFSDNSPQGFGLIQRERNYASYQDLEAHYERRPSLWIEPVGNWGQGAVVLTEIPTESEIHDNIVSFWKPRQPIPAGSEYHFAYRMSWGEEPVAKTNSVVVSRTASGRADIAKATPRRLFVVDYHLNGAMPDELPLAKVESSGGVISNVVIARNAANNGYRLAFELEPEDKELIELRAELKFSTPRQVETWLYRWTL
What is the function of this protein?
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
What are the official names of this protein?
Glucans biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the OpgD/OpgG family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PCKGC_RAT
Sequence: MPPQLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM
What is the function of this protein?
Cytosolic phosphoenolpyruvate carboxykinase that catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) and acts as the rate-limiting enzyme in gluconeogenesis (PubMed:4186849, PubMed:30193097, PubMed:26322521, PubMed:26709450, PubMed:28345895, PubMed:31461616).  Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle (PubMed:30193097).  At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed:30193097).  At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate (PubMed:30193097).  Acts as a regulator of formation and maintenance of memory CD8(+) T-cells: up-regulated in these cells, where it generates phosphoenolpyruvate, via gluconeogenesis (By similarity).  The resultant phosphoenolpyruvate flows to glycogen and pentose phosphate pathway, which is essential for memory CD8(+) T-cells homeostasis (By similarity).  In addition to the phosphoenolpyruvate carboxykinase activity, also acts as a protein kinase when phosphorylated at Ser-90: phosphorylation at Ser-90 by AKT1 reduces the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as donor (By similarity).  The protein kinase activity regulates lipogenesis: upon phosphorylation at Ser-90, translocates to the endoplasmic reticulum and catalyzes phosphorylation of INSIG proteins (INSIG1 and INSIG2), thereby disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins (SREBF1/SREBP1 or SREBF2/SREBP2) and subsequent transcription of downstream lipogenesis-related genes (By similarity).
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase, cytosolic [GTP], PEPCK-C, Serine-protein kinase PCK1.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Endoplasmic reticulum. Note=Phosphorylation at Ser-90 promotes translocation to the endoplasmic reticulum.
Protein: OTU1_DROME
Sequence: MTGSFSVKLKSKKGQFIVNDLNEHTTLGELKTKIVQATDIEATQLHVLVGYPPKPLDLSQQQEQRALKAVGINSGETLIVEEKAAPAPAAPVPGGTTVEDDEALARRLQAEEEAQLLQETAGGPVAQAADYQLPVAPTESGPNGDFNGILLKKVVPADNSCLFTSIRFVLNGKVDNEGSEMMRHIIAQEVAADPQSYNDAVLGKSNAEYCAWIQKADSWGGAIEVSILSNYYGIEIDVVDIQNAIINRFGEDKNFGLRVFLLFDGIHYDPLYMETSPSAAPATIFPVEELGVYQQAEQLANEAQSSRQYTNVDKFTLRCMQCDVRLVGQVQAQEHAKQTGHKNFGEI
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.
What are the official names of this protein?
Ubiquitin thioesterase OTU1.
Protein: DECA_DROPS
Sequence: MRAWILLLAVLATSQPIVQVASTEDTSISQRFIAAIAPTRTEPSAASAAAAAATATATATATTALAKAFNPFNELLYKSSDSDSDNNNNNYKNRNNNNNNLNKGPRNNKNKGNKHSKSDANRQFNEVHKPRTDQLENSKNKPKQLVNKTNKMAVKDQKHHQPQQQQQQHHKPATTTALTSTESHQSPIETIFVDDPALALEEEVASINVPANAGAIIEEQEPSTYSKKELIKDKLKPDPSTLVEIENSLLSLFNMKRPPKIDRSKIIIPEAMKKLYAEIMGHELDSVNIPRPGLLTKSANTVRSFTHKDSKIDDRFPHHHRFRLHFDVKSIPAEEKLKAAELQLTRDALAQAAVASTSANRTRYQVLVYDITRVGVRGQREPSYLLLDTKTVRLNSTDTVSLDVQPAVDRWLATPQKNYGLLVEVRTMRSLKPAPHHHVRLRRSADEAHEQWQHKQPLLFAYTDDGRHKARSIRDVSGGGGGGGGAGEGGKGNGGGRNRRHQRRPARRKNHEETCRRHSLYVDFADVGWDDWIVAPPGYDAYYCHGKCPFPLADHFNSTNHAVVQTLVNNLNPGKVPKACCVPTQLDSVAMLYLNDQSTVVLKNYQEMTVVGCGCR
What is the function of this protein?
Acts as an extracellular morphogen to establish at least two cellular response thresholds within the dorsal half of the drosophila embryo.  Required for the proper development of the embryonic dorsal hypoderm, for viability of larvae and for cell viability of the epithelial cells in the imaginal disks.  Acts together with scw (By similarity).
What are the official names of this protein?
Protein decapentaplegic, Protein DPP-C.
What is the protein family that this protein belongs to?
Belongs to the TGF-beta family.
What are the subcellular locations of this protein?
Secreted. Note=Is internalized by receptor- mediated endocytosis.
Protein: CAT4_STAAU
Sequence: MTFNIIKLENWDRKEYFEHYFNQQTTYSITKEIDITLFKDMSKKKGYEIYPSLIYAIMEVVNKNKVFRTGINSENKLGYWDKLNPLYTVFNKQTEKFTNIWTESDNNFTSFYNNYKNDLLEYKDKEEMFPKKPIPENTLPISMIPWIDFSSFNLNIGNNSNFLLPIITIGKFYSENNKIYIPVALQLHHAVCDGYHASLFINEFQDIIKKVDDWI
What is the function of this protein?
This enzyme is an effector of chloramphenicol resistance in bacteria.
What are the official names of this protein?
Chloramphenicol acetyltransferase, CAT.
What is the protein family that this protein belongs to?
Belongs to the chloramphenicol acetyltransferase family.