PharMolix/UniProtQA huggingface dataset:
Protein: RBM24_RAT
Sequence: MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQYSAAAAAAAAAAAYDQYPYAASPAATGYVTTGGYSYAVQQPITAAAPGTAAAAAAAAAAAAAFGQYQPQQLQTDRMQ
What is the function of this protein?
Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:27289039).  Plays a major role in pre-mRNA alternative splicing regulation (By similarity).  Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (By similarity).  Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity).  Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (By similarity).  Plays a role in the regulation of mRNA stability (By similarity).  Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (By similarity).  Involved in myogenic differentiation by regulating MYOG levels (By similarity).  Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (By similarity).  Promotes also the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (By similarity).  Plays a role in the regulation of mRNA translation (By similarity).  Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (By similarity).  Binds to a huge amount of mRNAs (By similarity).  Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity).  Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (PubMed:27289039).
What are the official names of this protein?
RNA-binding protein 24, RNA-binding motif protein 24.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm.
Protein: ATPA_ATRBE
Sequence: MVTIRADEISNIIRERIEQYNREVKIVNTGTVLQVGDGIARIHGLDEVMAGELVEFEEGTIGIALNLESNNVGVVLMGDGLLIQEGSSVKATGRIAQIPVSEAYLGRVVNALAKPIDGRGEISASEFRLIESAAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQQGQNVICVYVAIGQKASSVAQVVTTLQERGAMEYTIVVAETADSPATLQYLAPYTGASLAEYFMYRERHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSSSLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNSGIRPAINVGISVSRVGSAAQIKAMKQVAGKLKLELAQFAELEAFAQFASDLDKATQNQLARGQRLRELLKQSQSAPLTVEEQIMTIYTGTNGYLDSLEVGQVRKFLVELRTYLKTNKPQFQEIISSTKTFTEEAEALLKEAIQEQMKRFILQEQA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, chloroplastic, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein.
Protein: RL14_WOLWR
Sequence: MIQKNTLLEVADNSGARAVLCIGLLGGRKSASIGDTVIVSTKSITPRGKVEKGKVYRAVVVRVKSPIRKSDGSVIRFSSNAVVLINDQGEPLGTRVFGPVKKLSSGSFMKIMSLAVEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: IRAP_ECODH
Sequence: MKNLIAELLFKLAQKEEESKELCAQVEALEIIVTAMLRNMAQNDQQRLIDQVEGALYEVKPDASIPDDDTELLRDYVKKLLKHPRQ
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation.  Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway.
What are the official names of this protein?
Anti-adapter protein IraP.
What is the protein family that this protein belongs to?
Belongs to the IraP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_LEPIN
Sequence: MSRTKFIFVTGGVSSSLGKGVTVAALGCLLESRGYTVSLQKMDPYINIDPGTMSPYQHGEVYVTADGAETDLDLGYYERFTHSKLTRKNSVSTGQIYNTVIQRERKGDYLGRTVQVVPHITNEIRNRMYIVAREENPDFIIVEIGGTVGDIESIPFLEAIRQMRYEHGSSNVLFVHLTLVPTITAAGEAKTKPTQHSVKELLGLGIQPDILVCRVSQPMTKEMKNKLSLFCNVKEENVISASDISTSIYEIPKMYKEEKLDEVVLKTMGMELRESNFSEWDKMVKGLLTTKQTVQIAVVGKYISLQDAYRSIYESLSHGGIAHDTKVEFIKVDPENLNKDSYVEILKKVHGILVPGGFGDRGIEGKILAIQYARTNGIPFLGICLGMQCAVVEYGRNVLGLKDANSTEIRPDTEHPVISLLEEQNDIEQMGGTMRLGSYPCKVKENTLSYSEYKSILIHERHRHRFEFTNRYRKQYEENGMIIAGTSPDDNLVEIVEIPKHNWFIGVQFHPEFQSKPTLPHPLFAGFIRASVKYSKKG
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: RNH3_LACLS
Sequence: MNIVLKLSSNACQQLSEKYKSYEQTSKNPYIRFFAKVGKTSISVYTSGKVVFQGSDAEKIASEFGHVAQVVPKKQTNLIGTDEVGNGSYFGGLMVTASFVSDNHLKFLKEMGVADSKKLTDEKICQIAPKLIEEIPHVALVVEPEKYNEVIASGYNAVSIKVALHNQAIYLLEKQLGSQPESIVIDAFTTEANYKKYVSAEKNHPLTNVTLLTKAEDQFLAVAVSSIISRYKFLENLKKLSKESSFTLPSGAENLSDKVAAQIIKSQGIDALNHLAKLHFANTQKAMKIAQL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HIII, RNase HIII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. RnhC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPYK1_YEAST
Sequence: MSRLERLTSLNVVAGSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV
What are the official names of this protein?
Pyruvate kinase 1, PK 1, cell division cycle protein 19.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
Protein: RL27_GLAP5
Sequence: MATKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGSNVGMGKDHTLFATADGKVKFEVKGEKNRKYVSIIAE
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: DAPB1_PSEMX
Sequence: MKPTSLLLAATVLMSTPITSALAASATPPDVAKKPHVVKAPHGAERNDEYYWLRDDKRENKEMLAYLNAENAYTDAVMAPLKPLEDKLYDEVVARIKQDDASVPYRERGWWYYARFVTGKDYPVHARRKDGPGVDAVSIQAANAAGDFAGEQVLLDVNALGAGKDYYNVGDYEVSQDNRLLAYADDTNGRRQYTIRFKNLDTGELLPDTVTNAEPNLVWSDDGRTLFYVDKDPETLLSKRVKAHVLGTPASQDALVYEEEDDSFYMGIGRSRDDKFICISVESTVSSEMRCTPAASPGVFTVLAPRERDVEYQADHLGDRWVIRTNADGATNFKIVTAPTDSTSRKDWKDWVAHRDDVFVEGFELFDGFSVVAERANALESLRVIKADGSSDYVKADESAYSMGLSANPETGTDWLRYSYTSMTTPATTYEINTKTGERRQLKQQPVPGYDASKYVTERVWAPARDGKTKIPVTLVYRKDVARDGKAPMLQYAYGSYGASMDPNFSITNVSLLDRGVVYALAHIRGGQEMGRAWYDDGKLYNKINTFTDFIDVTDYLVKEGYAAKDRVAAMGGSAGGLLMGAVSNMAPEKYKVILTLVPFVDVVTTMLDPTIPLTTNEYDEWGNPEEKGYYDYILTYSPYDNLQAKAYPAMFVGTGLWDSQVQYWEPAKYVARLRDLNTGKGPVVFRTNMEAGHGGKSGRFRQYRERAEMFAFMLDQLGVASK
What is the function of this protein?
Sequentially removes dipeptide units (NH3-P2-P1-) from the amino termini of peptides and proteins.  Is able to catalyze the removal of Asp-Arg from the amino termini of angiotensins I and II.  Has slight endopeptidase activity on N-terminally blocked peptide derivatives which contain arginine residues at the P1 position.  Does not hydrolyze Ala-Ala-Ala and Ala-Ala-Ala-Ala substrates or isulin beta chain.
What are the official names of this protein?
Dipeptidyl aminopeptidase BI, DAP BI.
What is the protein family that this protein belongs to?
Belongs to the peptidase S9A family.
Protein: FLMC2_ECOLX
Sequence: MSSPHQDSLLPRFAQGEEGHETTTKFPCLVCVDRVSHTVDIHLSDTKIAVRDSLQRRTQGGGGFHGLRIR
What are the official names of this protein?
Protein FlmC homolog.
Protein: HFQ_XYLF2
Sequence: MAKGQSLQDPFLNALRRERVPVSVYLVNGIKLQGTIESFDQFVVLLRNTVSQMVYKHAISTVVPARNVRVGPGGGYVHSGSDTLQINDDEVE
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: NCAP_I93A0
Sequence: MASQGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNRYLEEHPSAGKDPKKTGGPIYKRVDGRWMRELVLYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDTTYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGIGTMVMELIRMIKRGINDRNFWRGENGRKTRSAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFSARSALILRGSVAHKSCLPACVYGPAVSSGYNFEKEGYSLVGIDPFKLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRLLSFIRGTKVSPRGKLSTRGVQIASNENMDNMESSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFEKSTVMAAFTGNTEGRTSDMRAEIIRMMEGAKPEEVSFRGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: EFG_FRAAA
Sequence: MPSDAPSSLASTRNIGIMAHIDAGKTTTTERILFYTGVNYKIGEVHEGGATMDWMEQEQERGITITSAATTCIWRDHTINIIDTPGHVDFTVEVERSLRVLDGAVAVFDAVAGVEPQSETVWKQADRYNVPRIAFVNKMDRVGAEFHRCVDMMVERLDATPAVIQLPWGVESDFRGVIDLIRMKGLLWKSEDKGASYEVVDIPRDHLEAAQEWRDKLLETVAENDDELMELYLEGEEPSEEQLMAGLRRGTLASKINPVLCGSAFKNKGVQPMLDAVVDFLPNPLDIGATIGHSVSDEDAEVRREPSEDEPFSALAFKIMSDPYVGKLTYIRVYSGRLTGGSPVLNSTKDRKERIGRILQMHANHREDRDGVGAGQIVAVVGLKNTTTGDTLCDPNAPVILESMTFPAPVIHVAIEPKTKADQQKLGTAIQRLAEEDPTFQVRTDEETGQTIIAGMGELHLDVLVDRMRREYGVEANVGKPQVAYRETIRRKVEKVDYTHKKQTGGSGQYARVIINLEPSGGDGGGYEFENKVTGGRIPREYIPSVDAGCQEAMEFGVLAGYPLVDVKVTLLDGQYHDVDSSELAFKIAGSMAFKDAARKADPVLLEPLMAVEVTTPEDHMGDVIGDLNSRRGQIQAMEERGGSRIVRAQVPLSEMFGYVGDLRSKTSGRASYSMQFDSYAEVPGNVAKEIIAKARGE
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPG_CAMJR
Sequence: MEYKRFKTRQIKVGNVLIGGDAPISVQSMLFTKTRDIEGSLEQINRLYFAGANIVRLACLDMADARALKEIKAKSPLPLIVDIHFNHNLAVYCAEFIDGVRINPGNIGSKENIKEVVKACKERGIPIRIGINHGSIEKQFSDKFGYGVDAMLESAMYNIKLLEDLDFFDIKISMKTSDAQKTIEAYERLRPLCDYPFHLGVTEAGTKFHSTVKSSIALGNLLLKGIGDTMRVSMTGELEEEIRVARAILQDSGVQKSGVNIISCPTCGRIQSDLLSAIKIVEEKTKHIKEPLNISVMGCVVNALGEAKGADVAIAFGKNQGLVIRHGEVVAKLKESELVDRFLAEVEDEVKSRAVKE
What is the function of this protein?
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin), 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the IspG family.
Protein: TYSY_CORGB
Sequence: MTVPTPYEDLLRKIAEEGSHKDDRTGTGTTSLFGQQIRFDLNEGFPLLTTKKVHFHSVVGELLWFLQGDSNVKWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPTPDGRHIDQISGALETLRNNPDSRRNIVSAWNVSELENMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFIWTGGDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFEYSFDDITVSGYDPHPLIRGKVAV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FMT_EHRCR
Sequence: MKIIFMGSPEFSVPALCALLEEKDHEVIAVYTRLPKPAGRRGKVLTKTPIHIIAEQNNIEVNTPKSLKHDYEQEKIFALNPDVIVVVAYGLIIPEAVLSIPKYGCINIHPSLLPRWRGAAPIHYAILSGDEQTGVTIMQMNELWDEGDILLQRDIPIDEQDNIDTLSQKLSNLGSSMLIEVLNNIDHLVPIKQNANDATYTNKIIDFHIDCNEEAQVICRKIRALYPKAFLFFNDKRLRILKANYCPDSDLQNLKPGTVINSHMHIKCKNGVLIPLIVQLEGKNPCSINDFIHGYSISNSSIT
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: MURQ_BACCR
Sequence: MLENLSTEHRNEKTMNLDEMSIKEVLQSMNEEDRTVALAVEKEIEQIEKVVQTVIKSFEEEGRLIYIGAGTSGRLGILDAVECPPTFGTDDKMVQGFIAGGLKAFTKAVEGAEDREELAEEDLKSIGLNEKDTVIGIAASGRTPYVIGGLKYAQSVGASTASISCNKNAEISKYANLNVEVETGAEILTGSTRLKAGTAQKLVLNMISTASMIGVGKVYKNLMVDVQSTNEKLVERSKRIIVEATGASYEVAAEYYEKAERNVKAAIVMVLLQCEYGEALEKLKYAKGFVKKAL
What is the function of this protein?
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
What are the official names of this protein?
N-acetylmuramic acid 6-phosphate etherase, MurNAc-6-P etherase, N-acetylmuramic acid 6-phosphate hydrolase, N-acetylmuramic acid 6-phosphate lyase.
What is the protein family that this protein belongs to?
Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
Protein: YJU2B_HUMAN
Sequence: MGERKGVNKYYPPDFNPEKHGSLNRYHNSHPLRERARKLSQGILIIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGAQRKEERWDMADNEQVLTTEHEKKQKLETDAMFRLEHGEADRSTLKKALPTLSHIQEAQSAWKDDFALNSMLRRRFREKKKAIQEEEERDQALQAKASLTIPLVPETEDDRKLAALLKFHTLDSYEDKQKLKRTEIISRSWFPSAPGSASSSKVSGVLKKLAQSRRTALATSPITVGDLGIVRRRSRDVPESPQHAADTPKSGEPRVPEEAAQDRPMSPGDCPPETTETPKCSSPRGQEGSRQDKPLSPAGSSQEAADTPDTRHPCSLGSSLVADYSDSESE
What is the function of this protein?
May be involved in mRNA splicing.
What are the official names of this protein?
Probable splicing factor YJU2B, Coiled-coil domain-containing protein 130.
What is the protein family that this protein belongs to?
Belongs to the CWC16 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: NTH_HUMAN
Sequence: MCSPQESGMTALSARMLTRSRSLGPGAGPRGCREEPGPLRRREAAAEARKSHSPVKRPRKAQRLRVAYEGSDSEKGEGAEPLKVPVWEPQDWQQQLVNIRAMRNKKDAPVDHLGTEHCYDSSAPPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDATLGKLIYPVGFWRSKVKYIKQTSAILQQHYGGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIANRLRWTKKATKSPEETRAALEEWLPRELWHEINGLLVGFGQQTCLPVHPRCHACLNQALCPAAQGL
What is the function of this protein?
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage (PubMed:9927729).  The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site.  The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination.  Primarily recognizes and repairs oxidative base damage of pyrimidines.  Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity.  Acts preferentially on DNA damage opposite guanine residues in DNA.  Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
What are the official names of this protein?
Endonuclease III-like protein 1, hNTH1, Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase, DNA glycosylase/AP lyase.
What is the protein family that this protein belongs to?
Belongs to the Nth/MutY family.
What are the subcellular locations of this protein?
Nucleus. Mitochondrion.
Protein: RL20_BURP6
Sequence: MPRVKRGVTARARHKKIINLAKGYRGRRNNVYRIAKQAVMRAGQYAYRDRRNKKRVFRALWITRINAAVRQHDMTYSVFINGLKKASIELDRKVLADMAVFDKAAFAAIVKQVKAAVAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NU6M_CARAU
Sequence: MTYFMFLLLMALVVGLVAVASNPTPYFAALGLVVAAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPEAWGSRSVLGYVLVYLLGVGLVAGFFWGGWYEGSWVVVDGLKEFSVLRGDVSGVAVMYSSGGGMLVICAWVLLLTLLVVLELTRGLSRGALRAV
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: GTSE1_MOUSE
Sequence: MDAGSKKEDFLLLEDEKFDFDLSLSSSSTNEDDEVFFGPVGHKERCIAASLDLNRRVPGQPLAPGSGSPCTLSPLTGEKFVEVYKEAHLLALQIESHSRREVAQAATPQNPVNQGKETFVQDSQLKVSLFEKEQKRDRSPMSLKRETFCLPSSRVQPPMGEPQLLASPGLLSSPVSAGPAQTQSNQGLPCSSQPLPRESSTSQPPSQAGPQKRITSKLQPPRALPVRGRNLHLATEKLKKEVPASIQRTKLVNEKGSQSDVLQDKPSTAPDAASREGHPGKRSLPIPGKLGLKKTLLKPPGYTGNLTRKSSTSGSASSLESGVYRSSVAGKAKSSEQRSSIPASGSQRRTSTSKSGRIGPAASRQALPAAPARVFGRQANKADAAQTVAEQPKVPTLSPLTQQPQTPEQRGPRLDPDTETPQLNKTVSIKRRDSYLSCKTEAVSTTTNPFKVPQFSVGESPGGVTPKFSRTHRLQSWTPASRVVSSTPVRRSSGTTPQGLPGSMRTPLSTRRMSVLPTPASRRLSSLPLMAPQSMPRALVSPLCVPARRLSSEPRRRSTVRAELTQESSGSGSGGQAQGLSSDESSSPPSSVPQALNFSPEKSASPPPQGSSTGAAQGEAEPPEDTLPSEVHGGGCSHTPSEGLLLDLKLDQLTITPEAGGRDLADCPLIDFSNTPESNTALGPSSWPLIDLIMNTPDMGRNDVGKPAKAELGQLIDLGSPLIQLSPEADKENVDSPLLKF
What is the function of this protein?
May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis.  Overexpression delays G2/M phase progression.
What are the official names of this protein?
G2 and S phase-expressed protein 1, GTSE-1, Protein B99.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Note=Associated with microtubules.
Protein: AC4CH_SHIBS
Sequence: MQPNDITFSQRFQDDILAGRKTITIRDESESHFKTGDVLRVGRFEDDGYFCTIEVTATSTVTLDTLTEKHAEQENMTLTELIKVIADIYPGQTQFYVIEFKCL
What is the function of this protein?
Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).
What are the official names of this protein?
N(4)-acetylcytidine amidohydrolase, ac4C amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the N(4)-acetylcytidine amidohydrolase family.
Protein: BESF_STREN
Sequence: MKLSKAVWALVLTVVTWASAFPAIRVGLDGYGVAGLSLSRLTVASVALAIAAGPLGVRRPRARDLPMIALCGATGMSAYQVLLNWGEVHVPAGTASLLIAIAPVFSVLLAAVFLGERMTWAQIAGSAVAISGAAVIAVAGGHARYTTSAWVVLAAAVVQGVYHFATKPLLARYTGLEVACYAMWAGTVFLLPLLPAMVHGFATAPVAATASTVYLGLLPSAIGFVSWGYAVARLSVASSTASLYLVPPVALVVAFVWLGEVPPPLALVGGALGIAGVMLINRRTLGRRREASTPGRR
What is the function of this protein?
Probably involved in the export of terminal alkyne-containing amino acids, namely L-propargylglycine (Pra) and L-beta-ethynylserine, that are antibiotics synthesized by enzymes encoded in the same gene cluster.
What are the official names of this protein?
Probable terminal-alkyne amino-acid exporter.
What is the protein family that this protein belongs to?
Belongs to the EamA transporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: FYV10_CANGA
Sequence: MAETTSLINEPDVDFHLKLNQHSFNIPYEQLQRNSRYLNRLIEKEIDELNSHYERLNIALGSGNIEGDKKALQELKDIIRSVEIFEKRLQKRVNEEVPILKRLEVRINFFKELENAKQQVADITPLMEWYLKFTNILIGDYLTRHTTSNSSPELGLPGVTFLEQEGIQDLLDTDILLTGNRISTALVDNHDLRPLLDWINDSKSYLKKNGSRLEFEARFQQYIELLKASEYEEAIKCFQDYLLKFVNTNFNELTHASGLLLSINYCKEIMKAKASERSAILTKDDGNPLENEIRAYKYFFHKKPKIVEQQHVKPVDLSYMNLSQNTDFEKYMLLLDDKRWGLLNELFLKDYYSLYGISQNDPLLIYLSLGISTLKTRECLHHRRVAKSSSPLVDKKVEEEVLQNSCPVCDKTFAPIAESLPFAHHTQSQLFDDPIMLPNGNIYEAKRLKRLAKYLVDIKAIELGETEVIDPIDKQIYNEADFITMYPT
What is the function of this protein?
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
What are the official names of this protein?
Protein FYV10.
What is the protein family that this protein belongs to?
Belongs to the FYV10 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NADD_PECAS
Sequence: MPSLTAFFGGTFDPIHYGHLQPVTALAKLVGLTQVVLMPNNVPPHRQQPEASSRQRFHMAELAVEGNPLFTVDDRELQRQTPSYTIDTLEALRAEKGHDAPLGFIIGQDSLLTLHHWHRWQDLLGVCHLLVCARPGYRSTLETPELQQWLDDHLTHAPEDLHQQPHGRIFLADTPLVTISATDIRQRRQQGLDCHDLLPPVVLRYINEHGLYQ
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.