PharMolix/UniProtQA huggingface dataset:
Protein: MSHD_CELFN
Sequence: MSSDIEAPTSLTSMRGALPPAVADDVRALHLTTVRHDGVPPLSEQPLLWLSDQEAPVVHVLAWHAVTGGAQELVGYAQVDVGSSTTARAELVVAPGHRRRGTGRSLLAHAAQEAASIPGRRLHVWAHGDLPAARATAAATGLVVVRELWRMAVDVTQHPPGAPQLPPGVAVRAFVPGQDEDAWRRVNARAFAHHPEQGRMTSADLRARESEPWFDPAGFLLAERDGQLLGSVWTKVHPGSEAPDGAPGEEVGEIYVVGVDPDAQGLGMGRALTALGLAHLRDRGLRTVILYTGAENTVAVHTYRRAGFARTAVDVMYGPPPAGSPAHGTPLVRVTDTPSSPGDATMGS
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: URK_SHEB2
Sequence: MNSQQCVIIAIAGASASGKSLIAKTIFDELRRDLGTDQIGVINEDAYYRDQSHLSMDERVLTNYDHPKALDHQLLCTHLQLLKSGEAVDIPCYSYTEHTRIAETLTMTPKKVIILEGILLLTDPKLRALMDASVFMDTPLDICFLRRLTRDVAERGRTMESVISQYKKTVRPMFLQFIEPSKQYADIIVPRGGKNRIATDILKTRIQHLLAK
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPTA_HERA2
Sequence: MDERRLIRVSKYLSKHLRHQPERLGLTLEPGGWVGVEQLLAACAANNVAISLAELHEVVEQNNKQRFGFDPTGQKIRAHQGHSVTVDLGLVAQQPPIILYHGTAKHNLAIILRDGLRPMQRQHVHLSRDRATALQVGARHGQAVILIVQADELFQAGQAFFCSDNGVWLTTAIDPAYLALER
What is the function of this protein?
Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P).  May function as an ADP-ribosylase.
What are the official names of this protein?
Probable RNA 2'-phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the KptA/TPT1 family.
Protein: HSCB_SHEB2
Sequence: MNYFELFKFSPAFDIDTALLAERYRELQRAVHPDKFANDTEQQKLLSVQRTAQVNDGFQTLKDPIRRAEHMLSLRGIELSHETTTVKDTGFLMQQMEWREALEDIRDSDDPQASIDELYQSFAQYRAQLTQQLTQLLTSEQAEDALLAADQVRKLKFMAKLHDELTRVEDALLD
What is the function of this protein?
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Seems to help targeting proteins to be folded toward HscA.
What are the official names of this protein?
Co-chaperone protein HscB homolog.
What is the protein family that this protein belongs to?
Belongs to the HscB family.
Protein: Y1388_STRPQ
Sequence: MTAILITGYRSFEIGIFDHKDPRVSIIKQAIRKDLIGYLENGVDWFIFTGNLGFEQWALEVANELKEEYPLQIATIFLFETHGDKWNEKNQEVLSQFRAVDFVKYYFPNYEQPTQFSQYYQFLLEKTEGAYVFYDTENETNLKYFLKKAKDMPYYQLLLLTFDRLNDMSQS
What are the official names of this protein?
UPF0398 protein SPs0474.
What is the protein family that this protein belongs to?
Belongs to the UPF0398 family.
Protein: SELA_DESDA
Sequence: MNNLFRSIPAVDLCLTALGQADPSLVEAPRGLMRDLITEFWDKKRHEIREGHCKKNEQLTLDACLPGLMTHVRAGLRSRFRAALNATGVVVHTNMGRSVLAKEAREAVITAATGYCNLELDMQSGGRGSRHALVEDLLCRLTGAEAALVVNNNAAAVLLVLDTFCKGGEVVVSRGELVEIGGSFRIPEVMEKSGATLREVGATNRTHLHDYSAAINENTRALMRVHTSNYRIVGFHSAVPLPELAALARRHDLPLIEDLGSGSLTDFSSCGLPDEPTVPSVLAQGADIATFSGDKVLGGPQAGIITGRKDMVDTLKRNPLTRALRCDKLCLAGLEATLRLYLDPEKARQKIPTLRMICRPAEELARAARTLAAALRKGLAGSSASCLVSLRADVSRVGGGAFPQYDLPTTLVCLKPENCSATALKAALLRTDPPLIGRLEDDSFCLDPRTLSAEDRPTLLRVLREALALAAKEII
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_CUPNH
Sequence: MSDTSNTPDNDGGKTAGGKPAAARTEAKAPPKSARRRSRELALQGLYQWLLNRNDIGAIQAHLHDAQGFNKADREHFDALLNGAVREEARLTAAFEPFLDRKVEELSPVERAALLVGSYELVHCLDIPYKVVINEAVELTKTFGGVEGYKYVNGVLDKLAAQVRAAEVAARR
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RET1_BOVIN
Sequence: MPVDFTGYWKMLANENFEEYLRALDVNVALRKIANLLKPDKEIVQEGDHMIIRTLSTFRNYIMDFQVGKEFEEDLTGIDDRKCMTTVSWDGDKLECVQKGEKEGRGWTQWIEGDELHLEMRVEGVVCKQVFKKVN
What is the function of this protein?
Cytoplasmic retinol-binding protein (PubMed:7744071).  Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis.
What are the official names of this protein?
Retinol-binding protein 1, Cellular retinol-binding protein, CRBP, Cellular retinol-binding protein I, CRBP-I.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm. Lipid droplet.
Protein: Y009_MYCGE
Sequence: MEYFDAHCHLNCEPLLSEIEKSIANFKLINLKANVVGTDLDNSKIAVELAKKYPDLLKATIGIHPNDVHLVDFKKTKKQLNELLINNRNFISCIGEYGFDYHYTTEFIELQNKFFEMQFEIAETNKLVHMLHIRDAHEKIYEILTRLKPTQPVIFHCFSQDINIAKKLLSLKDLNIDIFFSIPGIVTFKNAQALHEALKIIPSELLLSETDSPWLTPSPFRGKVNWPEYVVHTVSTVAEIKKIEIAEMKRIIVKNAKKLFWH
What are the official names of this protein?
Uncharacterized metal-dependent hydrolase MG009.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
Protein: SPT5_AERPE
Sequence: MEGGVDARFYAILVTSGAEVNVATIIAERARALGLDIRSIIVPPRIKGYVILEAHDPGDVYDATRGLRHVKRRRPLILKFEEVMKLVKPEVEIPALKPGQVVEIVAGAFKGMKARVIDVNQSKGQVTVSLLEPLFRATATIPIDEVRPVEE
What is the function of this protein?
Stimulates transcription elongation.
What are the official names of this protein?
Transcription elongation factor Spt5.
What is the protein family that this protein belongs to?
Belongs to the archaeal Spt5 family.
Protein: VKT2_CYRSC
Sequence: MGTARFLSAVLLLSVLLMVTFPALLSAEYHDGRVDICSLPSDSGDCLRFFEMWYFDGTTCTKFVYGGYGGNDNRFPTEKACMKRCAKA
What is the function of this protein?
Dual-function toxin that inhibits both serine proteases and voltage-gated potassium channels (Kv).
What are the official names of this protein?
Kunitz-type U15-theraphotoxin-Hs1a, U15-TRTX-Hs1a, Huwentoxin HW11c22, Kunitz-type serine protease inhibitor HWTX-XI-IS2.
What is the protein family that this protein belongs to?
Belongs to the venom Kunitz-type family. 03 (sub-Kunitz) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CPSF1_HUMAN
Sequence: MYAVYKQAHPPTGLEFSMYCNFFNNSERNLVVAGTSQLYVYRLNRDAEALTKNDRSTEGKAHREKLELAASFSFFGNVMSMASVQLAGAKRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLVYGTRLVVLPFRRESLAEEHEGLVGEGQRSSFLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIGGVVVFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQATFISYDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSLLLKYTEKLQEPPASAVREAADKEEPPSKKKRVDATAGWSAAGKSVPQDEVDEIEVYGSEAQSGTQLATYSFEVCDSILNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGHGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEDNPKGEGTEQEPSTTPEADDDGRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLALHKPPLHHQSKVITLCLYRDLSGMFTTESRLGGARDELGGRSGPEAEGLGSETSPTVDDEEEMLYGDSGSLFSPSKEEARRSSQPPADRDPAPFRAEPTHWCLLVRENGTMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEARREEATRQGELPLVKEVLLVALGSRQSRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGGGAEEGAGARGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMAIDGPVDSFAPFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCARIPRMTGEEKEFETIERDERYIHPQQEAFSIQLISPVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVTAHF
What is the function of this protein?
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition.  This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727).  May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity).
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor 160 kDa subunit, CPSF 160 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the CPSF1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: SRG5_CAEEL
Sequence: MSQNSSFSDIFEDGCDLTYDPLPENLKYLTQLFYMVPGIIIHFRILSIMLFQHRKIYMIQSFFIIFSMDSIASLTQLILDLFIQRVIIYIPQLCPSLYPLFEHYVLFPNIIFSIYNYMRAAKSIIQIFLTVNRMTCVLAPLRYSQIWRRFIPVTIAFITLSPFLVIWNVIISETFPVSIFGGFTLAYTKRVRWASLSMFQMIFMAISLTITVFTTSITLFKMRRLENRLKSSERTLCFASFYMSAAFFSAALFQSYFAFFSITAAYTDLVYFLQGFAFDVLNVGSPIVMVLISGQLRYHVIPVKSMAPKHSTVVSVTSVIRKT
What are the official names of this protein?
Serpentine receptor class gamma-5, Protein srg-5.
What is the protein family that this protein belongs to?
Belongs to the nematode receptor-like protein srg family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL22_ALKEH
Sequence: METSAKLKFSRLSPQKARLVADQVRGLPVEKALEILEFSPKKAAAIVRKVLDSAVANAEHNDGADIDALRVARIFVDEGPMLKRIRPRAKGRANRILKRTSHITVTVAEQQ
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: RL15_ECOBW
Sequence: MRLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFEGGQMPLYRRLPKFGFTSRKAAITAEIRLSDLAKVEGGVVDLNTLKAANIIGIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: PR2_PETCR
Sequence: MGAVTTDVEVASSVPAQTIYKGFLLDMDNIIPKVLPQAIKSIEIISGDGGAGTIKKVTLGEVSQFTVVKQRIDEIDAEALKYSYSIIEGDLLLGIIESITSKFTVVPTDGGCIVKNTTIYTPIGDAVIPEENVKEATEQSGMVFKAIEAYLLANPGAY
What are the official names of this protein?
Pathogenesis-related protein 2.
What is the protein family that this protein belongs to?
Belongs to the BetVI family.
Protein: OXDA_CRIGR
Sequence: MRVVVIGAGVIGLSTALCIHERFSPVQPLHMKIYADRFTPFTTSDVAAGFWQPYLSDPRNPQEVEWNQQTFDYLLSHIHSPNAEKMGLSLISGYNLFKEEVPDPFWRNTVLGFRKLTPREMDIFPDYGYGWFNTSLTLEGKSYLPWLTERLTERGVKLFHRKVESFEEVARGGADVIINCTGVWAGALQADTSLQPGRGQIIQVEAPWMKHFILTHDPRLGIYNSPYIIPGSKTVTLGGVFQLGNWNELNSVHDHNTIWKSCCKLEPTLKNAKIVGELTGFRPVRHQVRLKKKQLHFGSSSVEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKKLSRMPASHL
What is the function of this protein?
Regulates the level of the neuromodulator D-serine in the brain.  Has high activity towards D-DOPA and contributes to dopamine synthesis.  Could act as a detoxifying agent which removes D-amino acids accumulated during aging.  Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups.  Does not act on acidic amino acids (By similarity).
What are the official names of this protein?
D-amino-acid oxidase, DAAO, DAMOX, DAO.
What is the protein family that this protein belongs to?
Belongs to the DAMOX/DASOX family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: CP17A_HUMAN
Sequence: MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
What is the function of this protein?
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938).  Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways.  A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage.  The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (PubMed:9452426, PubMed:25301938) (Probable).  Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938).  Has 16-alpha hydroxylase activity.  Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA.  Also 16-alpha hydroxylates androgens, relevant for estriol synthesis (PubMed:27339894, PubMed:25301938).  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:9452426, PubMed:27339894, PubMed:22266943, PubMed:25301938).
What are the official names of this protein?
Steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane. Microsome membrane.
Protein: ADDB_THEP3
Sequence: MGIRFIYGRAGTGKTYFCLREIKEKINDGNSHPLILLVPEQFTFEAEKYLLETVEKDRKMRAQVLSFKTLANRVFTEVGGLTRQHVNSCGRSMVIYKIMEDLKENLKVYYKASRQQGFIKKISEVITEFKRFEVTPEKLMDTAESIQKEGLREKLRELSLIYGKFDELLHQKYIDEEDALTLLAEKLEYSEQFKGAEFWIDGFTGFTPKQYKVLEKLLKKAARVSVTLTMDTSKDSIDNTDLFYTTKKTEDKLLKICYENNISYEKPVDLNEGVPKRFEKNEEMAFLEKHLFSYPYKIYSKDTKNISLFKAVNVYSEVEETAREIIRLVRDENLRYSDIVVTARDLKRYHKLIKTIFSHYGIPHFIDLKLDIKNNPIIVYITSLFEIYLKNWSYESVFRHLKTGFTNLNKEDISFLENYVLANGIKGGKWKEEWKYSFRNRLDKLFDDQDEKEALEKVNTIKNGISEPLNKFYKDFSNANTVREACEILYNFLVERDIPQRIENLIREFKENKEFEIANQYSQIWDIVVDVLDQMVEVMGEEKINIDLFSKILDIGFEAYQIGSIPPALDEVLVTSVDRMKSHNAKALFVIGANDGIFPASSFEEGILTDEDRQILTSYEVELDRDTKAKVFEEQFLVYTALTSTSKFLRISYPIADHEGRSLRPSIIISRFKRIFPQITQFSNVIEMDTDEENLHRVSSPDPTFNEMIKSFKEWDIKDKINSLWLDVYNWYSNKEVWRKRIEKVLEGFNYSNQVRVIPSAKIKRLYKDEINFSVSRLEKYAACPFAYFVQYGLKAKERKIYSFDPPDLGIFMHNVLNEVSKALEKEDKTWEDLDREYCDEVVNIVVDNMLKGVSEHILKSSPRYEYLSKRLTRVLSNAVWVISEHIKRSSFIPSGHEVAFGENQMYPPIKIILSNGEEINLIGRIDRVDVFEKGEESYIRIIDYKSGNKELKLEDVFYGLELQLLIYLDAILESADKENTDIKPAGIFYFRIDDPIVKADKDITDEELQKEILKKLRLDGLVLKDAEIIKEMDKSINGTSYIIPASINKDGTIGKKTKGATKEQFELLRKHVKNMIKDLAEQMINGNISITPYRKGKETACKYCPYSSVCKFETNFEGNKYMFIKEQKEEEIWNMLQKEVNKDGDKVD
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease AddB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 1 subfamily.
Protein: GLNE_SALPA
Sequence: MTPLSSPLSQYCQTVVERLPEGFTETSLSAQAKSVLTFSDFALDSVIAHPEWLAELESASPQADEWRHYAGWLQEALAGVCDDASLMRELRLFRRRIMVRIAWAQTLSLVDDETILQQLSHLAETLIVGARDWLYAACCREWGTPCNPQGVPQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGETRGGRRELDNAQFFTRLGQRLIKALDQPTMDGFVYRVDMRLRPFGDSGPLVLSFAALEDYYQEQGRDWERYAMVKARLMGDNDDAWSRELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLKDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRSLLPTLDAIAALHLLPENDVAQLRMAYLFLRRLENLLQSINDEQTQTLPADDLNRARLAWGMKAENWPQLVGELTDHMANVRRVFNELIGDDEADTPQEEERSEPWREVWQDALQEDDSTPVLAHLADEDRRQVLTLIADFRKELDKRPIGPRGRQVLDQLMPHLLANVCSREDAAVTLSRITPLLAGIVTRTTYLELLSEFPGALKHLIMLCAASPMIASQLARYPLLLDELLDPGTLYQPTATDAYRDELRQYLLRVPEEDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWTQMVARYGQPAHLDERQGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDVMTNGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSADAFADYQQHEAWTWEHQALVRARVVYGDPQLTSQFDAVRRTIMTTARDGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFIAQYLVLRYAHEKPKLTRWSDNVRILELLAQNGIMDEHEAQALTVAYTTLRDELHHLALQELPGHVAQTCFSKERALVQASWRKWLVAV
What is the function of this protein?
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia.  When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity.  Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity.  The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
What are the official names of this protein?
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme, ATP:glutamine synthetase adenylyltransferase, ATase.
What is the protein family that this protein belongs to?
Belongs to the GlnE family.
Protein: SYM_ALBFT
Sequence: MPRQLFVTTALPYANGNFHIGHIMEYIQADIWVRYQRMMGNAVHFVCADDCHGAPIMIAAEKVGKTPQQFVADIASGRKPYLDGFHIGFDNWHSTDGAENHELAQAIYRDLKAAGLISTRVIAQFFDTEKNMFLPDRFIKGECPKCGAKDQYGDNCEECGAVYSPTELKNPYSALSGVTPVLRDSEHYFFKLSDPRCVEFLEQWTTDTNPRGQSRLQAEVYNKIKEWLLPDAEGKRDLGDWDISRDAPYFGIEIPDAPGKYFYVWLDAPIGYLAALKNRFIKLAGDATTGAQHYDDFMADPATEQYHFIGKDIITFHTLFWPAMLHFSGRKTPNAVFVHGFLTVNSEKMSKSRGTGLDPLKYLSLGMNPEWLRYYLATKLTARNEDVEFSPEDFMARVNSDLVGKYINIASRAAGFIAKRFGGQLGVISDDGAALLKQIQIERTSIEQLYEAREFAKALRETMLLADRVNEYVDANKPWELAKQTGMETRLHDVCTVCIEAFRALTAYLKPVLPLLAAQVEVFLNIEPLSFASVSQTLGAVHRIGDYKHLMQRVDIKQLEALFEAQAPVEPDNIATESVAPGGEGMAPVISMDDFSKIDLRIAKIVNCETVSGSTKLLRLTLDVGETNTRNVFSGIASSYQPEQLIGKLTVMVANLAPRKMKFGISDGMVLAASHADEKAQPGIYILEPFAGAQPGMRVH
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYGB_STRR6
Sequence: MTKNLLVELGLEELPAYVVTPSEKQLGEKMAAFLKENRLSFEAIQTFSTPRRLAVRVTGLSDKQSDLTEDFKGPAKKIALDSDGNFTKAAQGFVRGKGLTVEDIEFREIKGEEYVYVTKEEVGQAVEAIVPGVVDVLKSLTFPVSMHWAGNSFEYIRPVHTLTVLLDEQEFDLDFLDIKGGRVSRGHRFLGKETKIQSALSYEEDLRKQFVIADPCEREQMIVDQIKKIEAKHGVRIEIDADLLNEVLNLVEYPTAFMGSFDAKYLEVPEEVLVTSMKEHQRYFVVRDQDGKLLPNFISVRNGNAERLKNVIKGNEKVLVARLEDGEFFWREDQKLVISDLVEKLNNVTFHEKIGSLREHMIRTGQITVLLAEKAGLSVDETVDLARAAAIYKFDLLTGMVGEFDELQGIMGEKYTLLAGETPAVAAAIREHYMPTSAEGELPESKVGAVLAIADKLDTILSFFSVGLIPSGSNDPYALRRATQGVVRILDAFGWHIAMDELIDSLYALKFDSLTYENKAEVMDFIKARVDKMMGSTPKDIKEAVLAGSNFVVADMLEAASALVEVSKEEDFKPSVESLSRAFNLAEKAEGVATVDSALFENDQEKALAEAVETLVLSGPASQQLKQLFALSPVIDAFFENTMVMAEDQAVRQNRLAILSQLTKKAAKFACFNQINTK
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNJ1_STRP3
Sequence: MTNISLKPNEVGVFAIGGLGEIGKNTYGIEYQDEIIIVDAGIKFPEDDLLGIDYVIPDYSYIVDNLDRVKALVITHGHEDHIGGIPFLLKQANIPIYAGPLALALIRGKLEEHGLWREATVYEINHNTELTFKNMSVTFFKTTHSIPEPVGIVIHTPQGKIICTGDFKFDFTPVGDPADLQRMAALGEEGVLCLLSDSTNAEIPTFTNSEKVVGQSILKIIEGIHGRIIFASFASNIYRLQQAAEAAVKTGRKIAVFGRSMEKAIVNGIELGYIKVPKGTFIEPSELKNLHASEVLIMCTGSQGESMAALARIANGTHRQVTLQPGDTVIFSSSPIPGNTTSVNKLINTIQEAGVDVIHGKVNNIHTSGHGGQQEQKLMLSLIKPKYFMPVHGEYRMQKIHAGLAMDIGIPKENIFIMENGDVLALTSDSARIAGHFNAQDIYVDGNGIGDIGAAVLRDRRDLSEDGVVLAVATVDFNTQMILAGPDILSRGFIYMRESGDLIRESQRVLFNAIRIALKNKDASIQSVNGAIVNALRPFLYEKTEREPIIIPMVLTPDKH
What is the function of this protein?
An RNase that has 5'-3' exonuclease and possibly endonuclease activity.  Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity).  Has an overlapping but not completely redundant role with RNase J2 in the decay of mRNA.
What are the official names of this protein?
Ribonuclease J 1, RNase J 1.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM1_SERP5
Sequence: MTLLALGINHKTAPVSLRERVTFSPESIEQALTSLLQQPLVQGGVVLSTCNRTELYLSVEQQEHIHEQLVSWLCEYHHLRPEEVSKSLYWHHGNEAVSHLMRVASGLDSLVLGEPQILGQVKKAFAESQRGQSLSGELERLFQKSFSVAKRVRTETEIGASAVSVAFAACTLARQIFESLAELNVLLVGAGETIELVARHLREHKVRHMIIANRTRERAQLLADEVGAEVITLPEIDERLADADIIISSTASPLPIIGKGMVERALKARRNQPMLLVDIAVPRDIEPEVGKLANAYLYSVDDLHAIIQSNLAQRKAAAVQAESIVQQESINFMAWLRSQGAVETIRDYRSQADQIRAEMEAKALAAIAQGADVEQVIHELAHRLTNRLIHAPTKSLQQAAGDGDVERLQLLRDSLGLDQH
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.