PharMolix/UniProtQA huggingface dataset:
Protein: TPIS_SALHS
Sequence: MRHPLVMGNWKLNGSRHMVNELVANLRKELTGVAGCDVAIAPPEMYIDLAKRAAAGSHIMLGAQNVDLNLSGAFTGETSAEMLKDIGAQYIIIGHSERRTYHKESDELIAKKFAVLKEQGLTPVLCIGETEAENEAGKTEEVCARQIDAVLKTQGAAAFEGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAKADAKIAEQVIIQYGGSVNASNAAELFAQPDIDGALVGGASLKADAFAVIVKAAEAAKQA
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK36_SOLTU
Sequence: MKIRASVRKICEKCRLIRRRGRIIVICSNPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CYT1_OLISA
Sequence: NEGKAKCGNTAGSKLTFKSADECTKTGQK
What is the function of this protein?
Cytolysin that shows moderate hemolysis and moderate myonecrosis.
What are the official names of this protein?
Cytolysin Oshem 1, Small basic hemolytic peptide.
Protein: TLR6_MOUSE
Sequence: MSQDRKPIVGSFHFVCALALIVGSMTPFSNELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISCCPMASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQIPNTTVLHLVFHPNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKMLSISDTPFIHMVCPPSPSSFTFLNFTQNVFTDSVFQGCSTLKRLQTLILQRNGLKNFFKVALMTKNMSSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTCELRDFVKNIGWVAREVVEGWPDSYRCDYPESSKGTALRDFHMSPLSCDTVLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEKDDIRVCLHERNFVPGKSIVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPILQNNIPSRYHKLRALMAQRTYLEWPTEKGKRGLFWANLRASFIMKLALVNEDDVKT
What is the function of this protein?
Participates in the innate immune response to Gram-positive bacteria and fungi.  Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:19931471).  In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.  Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B. burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.  In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42.  In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36.  This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion (PubMed:20037584, PubMed:23812099).
What are the official names of this protein?
Toll-like receptor 6.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
Protein: GPMA_RHOPB
Sequence: MTDRLLVLVRHGQSEWNLKNLFTGWKDPGLTEKGVAEAIEAGKKLKAQGLVFDVAFTSVLTRAQTTLDLMLNELGQTGLPTSKNLALNERDYGDLSGLNKDDARKKWGEEQVHVWRRSYDVPPPGGESLKDTLARALPYYVQEILPCVLRGERTLVAAHGNSLRALIMVLEKLTPESILKRELGTGAPVIYRLNADSTVASKLDLAE
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: CSPLH_SELML
Sequence: MDASHPAVYPVGVPPTAVDPPPRVRMKDYEGMPSTLGGLVLRSGQFACAVTALSIMISIPDFSSVTAFCYLVAAMALQLLWSVSLAVVDGYALLLRRTLHNPVLLSLLVIGDWVTSTLSLAAACSSAGITVLIDSDLAQCAHNHCGRYEAAVAMAFLTWFLVSLSFFFSFWLLATR
What are the official names of this protein?
CASP-like protein 5A1, SmCASPL5A1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PP4P2_MOUSE
Sequence: MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPGTSGIPVINCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMICIFIAVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHGFA
What is the function of this protein?
Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity).  Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity).  Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (PubMed:29378918).
What are the official names of this protein?
Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase, Type 2 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase II, Transmembrane protein 55A.
What are the subcellular locations of this protein?
Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein.
Protein: MRH4_VANPO
Sequence: MMTSRLPSCFGLRFYAKRAATIRAKPSKLASSVGIGAKRSKKTVKKKGKEVDIFNYGKYVGLKERDPGSETKGKELLDKLSSFDQLKILPEVRNSIKNIIKDETLSKKAKESEDVIPSPIQLIAMKKLSRTLMDPKLQHHAIAAETGSGKTMAYLIPLFDYLKRQETEFPEDWEFMQDKAIIRSVIFLPTHELVDQVYNTVKKTENDLKFHVYKWDSGTKYPEIVEKLKNRIDILITTPAKLLNLFNIRMISRADRLLSEVKFVVLDEADTLLDKSWVEDTHRAIRSLPNTNHLLFCSATIPNDFNDTLERLFPNTIPITTPRLHKLPKSVDFKIIDSSINPFKGSKIKALAQTLYAIANDSSEPGFEKRCIVFTNEKKDVPYIVEKLKVTYGHDCIGLTSNDSVEERLEKIHDFITPPKPITMKKETPKIENEDSVEVEGSNITIGDFSSKTSVKNSNSESSLKVLVSTDLMARGLNFQGVRNLVLYDVPQTSIDLIHRVGRTARMQQRGRVFMITDKKTKSWAKALPKVIKKNMTLK
What is the function of this protein?
ATP-binding RNA helicase involved in mitochondrial RNA metabolism.  Required for maintenance of mitochondrial DNA (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase MRH4, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. MRH4 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: CLF1_DEBHA
Sequence: MNTDGLSREKVSDSQITSEQILQDAFQLKDEPLNRPKQSIQDLDELRSFQLTKRKEYEQQLNKNRLNFGQWLRYAKWEVKHNHDFPRARSIFERALEVNVQHIPFWTHYIQFELSHKNITHARNLLDRAVTTLPRVDKLWFLYVQTEETLKNYQMVRIIFERWLSWNPNPSAWDAYINYEKRYDEYDNAREIYIRYVQIHSSGEIWLKWIDFEMNDVPIDPEQVKRIRNVFELSVDSMLASEALRGDISLAEIINKWSLWEISVKEYERARAIFQLMLKSDTIQEIITPEQRNQIYSSYTEFEKSYGDKDTIESSIMIKRKLKYEEEVNKSPSDYDSWWSYISILQQEDNNEVTRETFERAIKVIPTDAFKSTVWRRYIYIWVKYAFWEEFTMGSIENGRNIWNKALKVIPHKRFTFAKIWISFAQFEIRNDPENGLASARKILGRSIGQSSTVKPKRKLFKFYIELEQKLGEWDRVRKLYEKWLELSLVGENNLSTINSLLTYIDFEKNIQEHQRCISLFELGVRLAEDDKIFTKVNPLEYMLMQFINYYKEEMRYAEARSLYRKLVERVSTPKVWISFALFESSIPTDSQLKAFEESTEEEFEFSIDETHRETTRSVFREANDFFKHNNLKEDRAVVIEAWKQYEEANGSEESLRDITKKLPVIVKRRRLIEGEEEEYLDYIFPEDEEAKPSKISGLNAFLANAQKWMANQN
What is the function of this protein?
Involved in pre-mRNA splicing and cell cycle progression.  Required for the spliceosome assembly and initiation of the DNA replication (By similarity).
What are the official names of this protein?
Pre-mRNA-splicing factor CLF1.
What is the protein family that this protein belongs to?
Belongs to the crooked-neck family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GALT5_RAT
Sequence: MNKIRKFFRGSGRVLAFIFVASVIWLLFDMAALRLSFSEINTGILKEDIMRREQTGFRVEADQMTILSPSSRGMRPPRNGAGGKESFRKAENRVLKVEENVDQVQRKGKMQFLLGRGKAVSLWHRTHVQTLPVTLPMQKTQGRDSKPEVSSLHMMSKQTTVLGSEKDSFTVSRGVPLNKTAEHTETLDKKQEAPENYNLSSDTSKQASQRALNVTISVRTDRSKQQSQTVTKSSIQFASLPILKPEEVTVTKKTEAQGKDLKYEAHKARPLLKFTADVGHLKKQSTNETGLGVLPEADGAKVAPGKKLNFSESQIVIITKEEGQKTDTKEVPNSKIQTVFPKLLGESQGKHIPRSQSQTLSSPLAPKRAVSQSKPTLAEELHTARSNLTAKATTVGHQQSHANISENPGKHHVLRIDVTLSPRDLNAPGQFGRPVVVPPGKKKEAEQRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNDLPTTSIIMCFVDEVWSALLRSVHSVLNRSPPHLIKEILLVDDFSTKDYLKANLDKYMSQFPKVRILRLKERHGLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLNRKKVACPVIEVINDKDMSYMTVDNFQRGVFTWPMNFGWRTIPPDVIAKNGIKETDIIRCPVMAGGLFSIDKSYFYELGTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDEYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCQSFKWYLDNVFPDLKAPVVRASGVFINLALGKCVSIKNITVVLEDCDGSSELQQFNYTWVRLIKHGEWCVAPIPDKGSLTLYPCDNRNNRLKWLHRSASAFHPELVDHIVFESYQQLLCMEGNFSQKTLKLAACNPTEPQQKWKFEKYYDV
What is the function of this protein?
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.  Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2, Muc1b, rMuc-2 or mG-Muc substrates.
What are the official names of this protein?
Polypeptide N-acetylgalactosaminyltransferase 5, Polypeptide GalNAc transferase 5, GalNAc-T5, pp-GaNTase 5, Protein-UDP acetylgalactosaminyltransferase 5, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: ATPL_MAGSA
Sequence: MEASAAKFIGAGLAAIGMIGSGIGVGNIWANLIATVGRNPSAKANVELYGWIGFAVTEAIALFALVVALMVLFA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: R4RL1_HUMAN
Sequence: MLRKGCCVELLLLLVAAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTTDRAARKEHHSPHGPTRSKGHPHGPRPGHRKPGKNCTNPRNRNQISKAGAGKQAPELPDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSASSLGASLLAWTLGLAVTLR
What is the function of this protein?
Cell surface receptor.  Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system.  Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum.  Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG.  Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans.  Binds heparin (By similarity).  Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200).  Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
What are the official names of this protein?
Reticulon-4 receptor-like 1, Nogo receptor-like 2, Nogo-66 receptor homolog 2, Nogo-66 receptor-related protein 3, NgR3.
What is the protein family that this protein belongs to?
Belongs to the Nogo receptor family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Perikaryon. Cell projection. Note=Localized to the surface of neurons, including axons.
Protein: PPN1_CAEEL
Sequence: MRLLLFSAALLLCSVPTWAFSLSSFFGSDVAQKPYLHPNSPPERDPASSRMKRQAYQVYVDGDVSVTVDKSGQKETGNWGPWVPENECSRSCGGGVQLEKRQCSGDCTGASVRYISCNLNACESGTDFRAEQCSKFNDEALDGNYHKWTPYKGKNKCELVCKPESGNFYYKWADKVVDGTKCDSKSNDICVDGECLPVGCDGKLGSSLKFDKCGKCDGDGSTCKTIEGRFDERNLSPGYHDIIKLPEGATNIKIQEARKSTNNLALKNGSDHFYLNGNGLIQVEKEVEVGGTIFVYDDAEPETLSAQGPLSEELTVALLFRKGSRDTAIKYEFSIPLEEEVDYMYKFDNWTPCSVSCGKGVQTRNLYCIDGKNKGRVEDDLCEENNATKPEFEKSCETVDCEAEWFTGDWESCSSTCGDQGQQYRVVYCHQVFANGRRVTVEDGNCTVERPPVKQTCNRFACPEWQAGPWSACSEKCGDAFQYRSVTCRSEKEGEEGKLLAADACPADEQEKFDTERTCNLGPCEGLTFVTGEWNLCTRCNDTEETREVTCKDSQGRAYPLEKCLVDNSTEIPTDTRSCATQPPCEYEWTVSEWSKCTTECGHGHKTRRVICAIHQNGGLEVVDEGHCQAEKPEGKTNCTNEEKCTGTWYTSSWSECTAECGGGSQDRVAVCLNYDKKPVPEWCDEAVKPSEKQDCNVDDCPTCVDSEFGCCPDNSTFATGEFNFGCSNCSETEFGCCADNVTVATGPNSKGCEEFVESPLNLEADVANADAEASGDAPELCSVTNENGEAVDVECATIAPITALLGDGELIGNDTDASNETIHCSKTEFGCCPDWYTAASGKGNEGCPSFTLGGCNETQFGCCHDDVTLARGANLEGCGEPSCAASLYGCCKDRKTIAFGPHYSGCERSSFPCELSDFGCCPDGETAALGKNGTGCGENCLTTKFGCCPDGKTTAKGSHNEGCGCEFAQYGCCPDGKSVAKGAGFYGCPESCAQSQFGCCPDGKTRARGENKEGCPCQYTRYGCCPDGETTALGPRNDGCDNCRYAKHGCCPDGETKALGPDGAGCPPTTTPPFLMGGTVAPHKIAACNQTQESGTVCGAGYKLAWHYDTTEGRCNQFWYGGCGGNDNNFASQDMCETICVEPPGKGRCYLPRVDGPLRCDQLQPRYYYDHSKKHCVAFWWRGCLGNANNFNSFEECSMFCKDVGPYDAPTTAAPPPPPQQNAQQYLPTPEVQQIEIQSAEQPQPQQPQQQQQQQQQQPQQPRQSMEDICRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRCFFVHGAQPSAARQEQAQPAAQPAQPAQPSNIVSPPQQSASPVVVPSNSKQRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVKPASEAASAGIDGAAGINSVCDEAKDTGPCTNFVTKWYYNKADGTCNRFHYGGCQGTNNRFDNEQQCKAACQNHKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCPKDDQTTTTSQPEELPSLPLVQEDPQPRPAFSLKQSFAHSRRRDAPFARSVSARHHTPDSEEERVDCYAVPDPGSCGDYRLVWHYSATSNSCRQFYYGGCAGNTNRFETRDKCETSCVAKIEERVESVSEASKSLEEVRLTDPRMDSHFGYHDPEVDQIEEEAEYVIVDTGALPELCMLPEQRGSCYDNILRWRFDSEKSQCVTFMYSGCNPNANHFTSQETCERACGKWRNVAVCELPAEHGDCQLAIPRWYHDPKTSQCQMMMWTGCGGNGNAFSSKADCESLCRVETLWSNNTDFCTLERSAGPCTDSISMWYFDSTHLDCKPFTYGGCRGNQNRFVSKEQCQQSCRPGDTKSEDICTLRPEPGPCRLGLEKYFYDPVIQSCHMFHYGGCEGNANRFDSELDCFRRCSSVKVEASESERVGQLTSASTPVIYIVNKTAIFVGNTFRIRCNSYGVLPITWYKNGGLLQFGSRITEENDDTLEIVDALTADAGVYTCIAGQDSTMSEGVEVVIKRLPGHRTTSRPMLTPSKNFSLGTPPTPSPSTVSTTPFRIYTPGSAPSDARVSRPTSNSCMDVGNASTCDLIVKNGLCGKKRYGTFCCHTCTRVHNFKF
What is the function of this protein?
Plays a role in post embryonic distal cell tip migration (PubMed:19297413).  Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo (PubMed:11076767).
What are the official names of this protein?
Papilin, Abnormal cell migration protein 6.
What is the protein family that this protein belongs to?
Belongs to the papilin family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix, basement membrane.
Protein: PHB1_HUMAN
Sequence: MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
What is the function of this protein?
In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity).  Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity).
What are the official names of this protein?
Prohibitin 1.
What is the protein family that this protein belongs to?
Belongs to the prohibitin family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane.
Protein: RIMM_STRPF
Sequence: MEYFNVGKIVNTQGLQGEMRVLSVSDFAEERFKKGSQLALFDDKDRFVQEVTIVSHRKQKHFDIIKLKDMYHINAIEKYKGYTLKVSKDNQGDLQEGEFYYHQIIGMAVYEKDRLIGYVKEILQPGANDVWVVKRQGKRDLLLPYIPPVVLNVDVPNKRVDVELMEGLDDED
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y640_METJA
Sequence: MNLKKVVNEIRNFEGILRKIAIKDVVETFDFNDEDYEFDIIVDFGDDAAVIGIDGDNAILLAADGIWGKLLEADPWWAGYCSVLVNCKDIAAMGGKCVGMTNIISIKDKDICREVLKGVKDGVKKFGVPMVGGHTHPDAMCNVLDVSITGIAKKDCILRSDNAKIGDKIIFAYDLVGQIYKSFPLNWDTTTMKSKKLVRAQMDALVQIAENKLANSCKDISNPGAIGTLGMLLEVSRKGGVVDITKIPKPEEIDLIHWLKVYPGSGYVLTAKEENFKEIKDIFEDVEMTAEICGEVIAEKKLYITDGENKEVVFDFEKEFICGC
What are the official names of this protein?
Uncharacterized protein MJ0640.
Protein: PYRB2_PEA
Sequence: MTASSSLFSCSMHMEVLTPKISKWPKNFVSCHSKISYVETNYLKSTCYPISRFFCINNLKKTRQRDGIHCFSEGQKFQLDDVVEAQQFDRDILNAIFEVARDMEKIERNSPESQILKGYLMATLFYEPSTRTRLSFESAMRRLGGEVLTTENAREFSSAAKGETLEDTIRTVEGYSDLIVLRHFESGAARRAATIAGIPIVNAGDGPGQHPSQALLDVYTIEREIGKLDGIKVGLVGDLANGRTVRSLTYLLAKYKDVKIYFVSPEVVKMKDDIKDYLTSKGVDWEESSDLVEVASECDVVYQTRIQKERFGERLDLYEKARGKFIVNQNILNAMQRHAVIMHPLPRLDEITVDVDADPRAAYFRQAKYGLYIRMALLKLLLVGW
What are the official names of this protein?
Aspartate carbamoyltransferase 2, chloroplastic, Aspartate transcarbamylase 2, ATCase 2.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RL24_MESH7
Sequence: MGKIRKNDTVVVLSGDDKGKQGAVLELIPAKKAAIVKGVNIKTKHRKPSNKNTNGEIITFEAPILLSKLALVAKKATKDKPAIPTRVGFKIENKKKIRIAKKTGKAI
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: FIP1_PONAB
Sequence: MSAGEVERLVSELSGGTGGDEEEEWLYGDENEVERPEEENASANPPSGIEDETAENGVPKPKVTETEDDSDSDSDDDEDDVHVTIGDIKTGAPQYGSYGTAPVNLNIKTGGRVYGTTGTKVKGVDLDAPGSINGVPLLEVDLDSFEDKPWRKPGADLSDYFNYGFNEDTWKAYCEKQKRIRMGLEVIPVTSTTNKITAEDCTMEVTPGAEIQDGRFNLFKVQQGRTGNSEKETALPSAKAEFTSPPSLFKTGLPPSRNSTSSQSQTSTASRKANSSVGKWQDRYGRAESPDLRRLPGAIDVIGQTITISRVEGRRRANENSNIQVLSERSATAVDNNFSKPPPFFPPGAPPTHLPPPPFLPPPPTVSTAPPLIPPPGIPITVPPPGFPPPPGAPPPSLIPTIESGHSSGYDSRSARAFPYGNVAFPHLPGSAPSWPSLVDTSKQWDYYARREKDRDRERDRDRERDRDRDRERERTRERERERDHSPTPSVFNSDEERYRYREYAERGYERHRASREKEERHRERRHREKEETRHKSSRSNSRRRHESEEGDSHRRHKHKKSKRSKEGKEAGSEPAPEQESTEATPAE
What is the function of this protein?
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition.  FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition.  Binds to U-rich RNA sequence elements surrounding the poly(A) site.  May act to tether poly(A) polymerase to the CPSF complex (By similarity).
What are the official names of this protein?
Pre-mRNA 3'-end-processing factor FIP1, FIP1-like 1 protein.
What is the protein family that this protein belongs to?
Belongs to the FIP1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEUD_DESVH
Sequence: MRYAGTAHKVGDHIDTDAIIPARFLVTTDAQKLGENCMEGLEHGWVARVKSGDIMVGGRNFGCGSSREHAPIAILGAGMPVVVAHSFARIFYRNGFNMGLLLLEVGDDVDKIADGDDIEVDAASGVITNRTTGATITCAPVPQSMRELLDTGGLVPYVRARLERENG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: NU2C1_ORYSI
Sequence: MIWHVQNENFILDSTRIFMKAFHLLLFQGSFIFPECILIFGLILLLMIDLTSDQKDRPWFYFISSTSLVISITALLFRWREEPIISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVALECFSLCSYLLSGYTKRDLRSNEATMKYLLMGGASSSILVYGFSWLYGLSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGLGFKLSLAPFHQWTPDVYEGSPTPVVAFLSVTSKVAALALATRILDIPFYFSSNEWHLLLEILAILSMILGNLLAITQTSMKRMLAYSSIGQIGYVIIGIIVGDSNDGYASMITYMLFYISMNLGTFACIVLFGLRTGTDNIRDYAGLYTKDPFLALSLALCLLSLGGLPPLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVLSIYYYLKIVKLLMTGRNQEITPYVRNYRRSPLRSNNSIELSMTVCVIASTILGISMNPILAIAQDTLF
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 2 A, chloroplastic, NAD(P)H dehydrogenase, subunit 2 A, NADH-plastoquinone oxidoreductase subunit 2 A.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: CLPX_ACAM1
Sequence: MSKYDSHLKCSFCGKSQEQVRKLIAGPGVYICDECVDLCNEILDEELFDTASSMPAASRAPVAERKRSQSAPLSLNQIPKPRDIKSYLDEHVIGQDEAKKVLSVAVYNHYKRLSISQASADSVAELDDAIELQKSNILLIGPTGCGKTLLAQTLAQMLDVPFAVADATTLTEAGYVGEDVENILLRLLQVADLDVEEAQRGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKMLEGTVANVPPQGGRKHPYQDCIQIDTTNILFICGGAFVGLDKIIEQRTGKKAMGFIQDGELRAKEQRTADMLRDLEAEDLVKFGMIPEFTGRIPVMSVIDALDEDVLCQILTEPRNALVKQYQKLLRMDRVELEFQPDAIRAIAQEAYRRRTGARALRAIVEEIMLDVMYELPSQSRKELTQCLITRSMVEQRSTAELLVHPSAISTPESA
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.