PharMolix/UniProtQA huggingface dataset:
Protein: URIC_RAT
Sequence: MAHYHDDYGKNDEVEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLRSKKDYLHGDNSDIIPTDTIKNTVHVLAKFKGIKSIETFAMNICEHFLSSFSHVTRAHVYVEEVPWKRFEKNGVKHVHAFIHTPTGTHFCDVEQVRNGPPIIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCKWRYQNRDVDFEATWGAVRDIVLKKFAGPYDRGEYSPSVQKTLYDIQVLTLSQLPEIEDMEISLPNIHYFNIDMSKMGLINKEEVLLPLDNPYGKITGTVRRKLPSRL
What is the function of this protein?
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
What are the official names of this protein?
Uricase, Urate oxidase.
What is the protein family that this protein belongs to?
Belongs to the uricase family.
What are the subcellular locations of this protein?
Peroxisome.
Protein: LRGA_STAAB
Sequence: MVVKQQKDASKPAHFFHQVIVIALVLFVSKIIESFMPIPMPASVIGLVLLFVLLCTGAVKLGEVEKVGTTLTNNIGLLFVPAGISVVNSLGVISQAPFLIIGLIIVSTILLLICTGYVTQIIMKVTSRSKGDKVTKKIKIEEAQAHD
What is the function of this protein?
Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB.  The LrgAB and CidAB proteins may affect the proton motive force of the membrane.  May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses.
What are the official names of this protein?
Antiholin-like protein LrgA.
What is the protein family that this protein belongs to?
Belongs to the CidA/LrgA family. LrgA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y1291_METJA
Sequence: MNKSGMSLIITMLLLIGTAIVIGAAYYAWSNKVFSDTTEKITPTIKSSIGNIIKPIEISTIETYYFTNLDLNGDSRITNNPEERFIQTIKLEFINNIDEDLNVNTRIYCLTPNVSWASVNIDDSSNNLLLDRDENPYNYSGQYVYFNGTVYYSSMKFYDENGKLFYAAASNGNALNTSNLLDLIDLNCPTESFLLKGNSKTDINYYILINNTKVPNTIIFEIIASTKYGDVEKKITFEIS
What are the official names of this protein?
Uncharacterized protein MJ1291.
Protein: PGAP3_MOUSE
Sequence: MAKRTAPLLLLTLAVGLAGGSQGDREPVYRDCVLRCEERNCSGDALKHFRSRQPIYMSLAGWTCRDDCKYECMWFTVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSVYLCCVRTVGLQHPSVASAFGALLLLLLTGHISYLSLVHFDYGYNMMANVAIGLVNLAWWLVWCLRNRQRLPHTRRCMVVVVLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHTLFFRFLEDDSLYLLKESGAMFKLD
What is the function of this protein?
Involved in the lipid remodeling steps of GPI-anchor maturation.  Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins.  Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (By similarity).
What are the official names of this protein?
Post-GPI attachment to proteins factor 3, PER1-like domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the PGAP3 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Mainly localizes to Golgi apparatus.
Protein: MYOF_DICDI
Sequence: MEPLPLENEDNQLNSNKSTTVSSKNFSNIFHNNIHNKDVVGLTDMCFLENVEENELMNNLQNRFNKDHIYTYIGEQVISVNPFSNKANIYTEQVLKSYQNMYMYEVSPHIYALAQDTYKKLLLSKESQCVIITGESGSGKTEASKIFLNYISKVCSGNLENIQGIMRLIIESNIVLESFGNAKTLRNDNSSRFGKFIEIEFDGKGSPISGKISQFLLEKSRVHSRAIGERSFHVFYQFLTDKRITSKLGLSNDPTQYKYLKDSMCFSISSINDSKDFQKVLESLKQLAWTEQEMESIWRVLGAILLIGNIEFSNDVEKSNVDAVYISTPETLKKVSQLLQCSEDSLEKSLISRSLTLGAGKRQSSIKVLLNQTQAKETRDAFSKVLYDRLFTSIIDKINSTISSKSNNGSNYIIESTIGILDIYGFEIFENNSFEQFIINYSNEKLQQLFINLVLRQEQEEYLKEGIEWKTIDNYFDNTPIIDLIEGQPVGLLKLLEEACLIGQSTPELLIQKFNQFFSKNKHFESFETSNNLSIESQSFTLKHYASPVTYNLDSFIYKNKDPLYQDLIFTMESSKDKFILSLFNKDFQKNSLGVKKIPITAATQFKNAINDLIGKLNTCQPHYIRCIKSNEDKRSNHFDYEAVRHQVRYLNMLETIRVRKAGYCHKQHYTRFLGRYKMISKETWPFWNGTPKDGVMAIVRAASAIQNSTSECQFGKKKLFIKSASTLFHFEELRQKILPSIVITIQRVWRGYKVRKWYKQELQRLREEKEEIQKQIKRKNSANLIQTYYLRYKVLTYIKKLKPWSVGPHYNKGHIMPTLWLRRTPIDSLMQSIHIIWWAKVKVTSLSMEARSLVRQKILALDLFGMGYSRKKEWDCRRKFQADYLSDDSNPKKSQFSESVQAMFQKGGDKEILFADNVIKINKRGKSQLRSLIITDQHIYKYDTKKYTQKKVGLKLHSIVALSTSNKKDTFLAIHFKQPIRDLYIDLGCDFVEKVSEVCTNLVQQVYKLTGTTIPLVFRDPLTFNNSRDSRNNGTDFVVSFSQYPKGKEQRQSTFVKGKGNTAIVYYNLD
What is the function of this protein?
Myosin is a protein that binds to actin and has ATPase activity that is activated by actin.
What are the official names of this protein?
Myosin IF heavy chain.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Protein: KPRH_STRCO
Sequence: MRDIAVFSGSAHPDLAEEVCAQLGVPLSPTRVSRFANDCLEVQLMANCRERDVFLVQPLVTPVQEHLVELLMMCDAARGASAGRITVVMPHYSYARSDKKDAPRISLGGRLVADLLVAAGASRVLAMTLHSPQVHGFFSVPVDHLHALRELAAHFRQYDLSRATVVSPDLGNAKEAAAFARMLGAQVAAGAKQRYADDRVSISSVIGDVAGRDVIVLDDEIAKGSTVLELLDRLRESGPRTIRLACTHGLFAAGALGRLSEQPDVLEIVCTNTVPVPADDHTDKLRILSIAPALAEAVRRIHNGESVSALFDARPAG
What are the official names of this protein?
Putative ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, P-Rib-PP synthase, PRPP synthase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family.
Protein: PFPA_RICCO
Sequence: MDSDFGIPRELSDLQKLRSLYKPELPPCLQGTTVRVELGDGTTACSEAGAHTISRSFPHTYGQPLAHFLRATAKVADAHIISEHPAMRVGVVFCGRQSPGGHNVVWGLHNALKIHNPNSTLLGFLGGSEGLFAQKTLEVTDDILSTYKNQGGYDLLGRTKDQIRTTEQVHAALTTCKNLKLDGLVIIGGVTSNTDAAQLAETFAEAKCPTKVVGVPVTLNGDLKNQFVETNVGFDTICKVNSQLISNVCTDALSAEKYYYFIRLMGRKASHVALECTLQSHPNMVILGEEVAASKLTLFDLTKQVCDAVQARAEQDKYHGVILLPEGLIESIPEVYALLKEIHGLLRQGVSPNNISSQLSPWASALFEFLPPFIKKQLLLYPESDDSAQLSQIETEKLLAHLVEAEMNKRLKEGTYKGKKFNAICHFFGYQARGSLPSKFDCDYAYVLGHICYHVLAAGLNGYMATATNLKNPVNKWRCGAAPIAAMMTVKRWAQNPGATSIGKPAIHPAAVDLKGKAYELLRLNAVKFLMDDLYRNPGPLQFEGPGADAKPITLCVEDQDYMGRIKKLQEYLDKVRTIVKPGCSQEVLKAALSVMASVTDVLLTMSSTSLDGQKPL
What is the function of this protein?
Regulatory subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase.
What are the official names of this protein?
Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha, PFP, 6-phosphofructokinase, pyrophosphate dependent, PPi-PFK, Pyrophosphate-dependent 6-phosphofructose-1-kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPA_MACCJ
Sequence: MNIHFKGTGVAVTTPFNGQTIDYNLFEDHLNFLINNNVEALIINGTTGEGSTLTEDEKLKTIEIAVRVAHGRVPVIAGTGTNNTQATIEHSLKAKALGVDSIMLITPYYNKTNQRGLLAHFTTIADAVELPVLLYNVPARTNMTIEQETVAALAEHPYIYGIKDATGDINYMKTLKSVVPDDFALYSGNDDAVLPFYEAGGDGVISVIANAIPAEFSDIYRTYQVNRHEAERQFNNLLPLINALSVDVNPIPIKALVAYIGYANGELRLPLVPMLEQDTKQLIELYNRIAKGSDLS
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACP_STRPQ
Sequence: MAVFEKVQEIIVEELGKETEEVTLETTFDDLDADSLDVFQVISEIEDAFDIQIETEEGLNTVGDLVAYVEEKSK
What is the function of this protein?
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
What are the official names of this protein?
Acyl carrier protein, ACP.
What is the protein family that this protein belongs to?
Belongs to the acyl carrier protein (ACP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAN3_ASPNC
Sequence: MATTGKSATLEDARHGTGSPKMKGRENAKDTLCRNVTIYGRCRYEDKGCAFNHDPHKVNSGYQSDSNKKRLNVDSPSFTPSILSSNGSSPTSQSATMKKMATISPKAASAAPFQPRSISSRSNSSTPTTRPGTMTPDWSVAEVQEFVPQGFDTAHIGSLQGNGTAGVPSTSAFDPFVTAPNPLSAANAVGPVQANPFSHDTAAALNGAAFFANQSGFQQPVQYHMYAPIGPHSQNTLGYQRNVHDLFLPNDLREEMQKKAAATLQTLPNTQLPAQVDYFHSLVPLDLNHQKNATIFGFPSWVYKAQSSKDGNFYALRRLEGFRLTNEKAIRSVQAWKRVCNGSVVTVHDAFTSRSFQDSSLIFVTDYHPLSKTLAEQHLGAGNRFQGRHNTHIPEQVLWGYMTQIANALKAIHASQLAARIIDPSKILLTGRNRIRLNACAIMDVVQFDTQRSLAELQRQDLVNFGQLIVTLGANQPNVMHNPTKAMEHFTRAYTAQLKNSVFWLLNGLQKDQERNIDIFITGISSTLMSTFDSALHLDDQLTSDLSRELENGRLVRLMTKLNFVNERPEYEHDRQWSENGERYFLKIFRDYVFHQVDAQGDPVVDLGHVLMCLNKLDAGTDEKITLISRDEQSCFVVSYKELKKALESSFQALLKPSASRRLH
What is the function of this protein?
Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover.  PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1.  PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex.  Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by xrn1.  May also be involved in post-transcriptional maturation of mRNA poly(A) tails.  pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit pan2 to mRNA via its interaction with RNA and with pab1.
What are the official names of this protein?
PAN2-PAN3 deadenylation complex subunit PAN3, PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. PAN3 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NCBP2_DROAN
Sequence: MSTSVDLSSYRDQHFKGSRSEQERSLRDSTTLYVGNLSFYTTEEQIHELFSRCGDVRVIVMGLDKYKKTPCGFCFVEYYTRAEAEAAMRFVNGTRLDDRLIRVDWDAGFIEGRQYGRGKTGGQVRDEYRTDYDAGRGGYGKLLSQKIAPNTDNR
What is the function of this protein?
Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi).  The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing.  Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production.  In the CBC complex, Cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires Cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure (By similarity).
What are the official names of this protein?
Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, NCBP 20 kDa subunit, CBP20.
What is the protein family that this protein belongs to?
Belongs to the RRM NCBP2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YQ41_CAEEL
Sequence: MLRSLSNQNLRTIFFLISTTNSKAAVMRCLDFHSVPQERTVKKFLLEDSHLMRVEVCNLCARNLEICECGSQQEKCELIYGNLKKWLELILNCYRNIIIQTKKSMFEELPSSCPMSKGILKQKLLDEMADDEMWMIMIMSFRL
What are the official names of this protein?
Uncharacterized protein C13B9.1.
Protein: CHI1_SOLTU
Sequence: EFTTLFLLFSVLLLSASAEQCGSQAGGALCASGLCCSKFGWCGDTNDYCGPGNCQSQCPGGPGPSGDLGGVISNSMFDQMLNHRNDNACQGKGNFYSYNAFISAAGSFPGFGTTGDITARKREIAAFFAQTSHETTGGWPTAPDGPYAWGYCFLREQGSPGDYCTPSSQWPCAPGRKYFGRGPIQISHNYNYGPCGRAIGVDLLNNPDLVATDSVISFKSAIWFWMTPQSPKPSCHDVITGRWQPSGVDQAANRVPGFGVITNIINGGLECGHGSDSRVQDRIGFYRRYCGILGVSPGDNLDCGNQRSFGNGLLVDTM
What is the function of this protein?
Defense against chitin-containing fungal pathogens.
What are the official names of this protein?
Endochitinase 1.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.
What are the subcellular locations of this protein?
Vacuole. Note=Vacuolar and protoplast.
Protein: UBR7_MOUSE
Sequence: MAGAESPTECQAELEPVVSLVDVLEEDEELENEACAVLGGSDSEKCSYSQGSVGRQALYACSTCTPEGEEPAGICLACSYECHGSHKLFELYTKRNFRCDCGNSKFKNLECKLFPDKSKVNSCNKYNDNFFGLYCVCKRPYPDPEDEVPDEMIQCVVCEDWFHGRHLGAIPPESGDFQEMVCQACMRRCSFLWAYAAQLAVTRISAEDDGLLPNATGMGDEDVSKPENGAPQDNGLKEDAPEHGRDSVNEVKAEQKNEPCSSSSSESDLQTVFKKENIKTEPQSSCRLQELQAKQFVKKDAATYWPLNWRSKLCTCQDCMKMYGELDVLFLTDECDTVLAYENKGKNDQATDRRDPLMDTLSSMNRVQQVELICEYNDLKTELKDYLKRFADEGTVVKREDIQQFFEEFQSKKRRRVDGLQYYCS
What is the function of this protein?
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway.  Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
What are the official names of this protein?
Putative E3 ubiquitin-protein ligase UBR7, N-recognin-7, RING-type E3 ubiquitin transferase UBR7.
Protein: RLMM_ECO57
Sequence: MNKVVLLCRPGFEKECAAEITDKAGQREIFGFARVKENAGYVIYECYQPDDGDKLIRELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELLKFCRKFTVPLRAALRDAGVLANYETPKRPVVHVFFIAPGCCYTGYSYSNNNSPFYMGIPRLKFPADAPSRSTLKLEEAFHVFIPADEWDERLANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFKFRPTRSNISWMVCDMVEKPAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYIQAQLDEHGINAQIQARQLYHDREEVTVHVRRIWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METXA_DEFDS
Sequence: MKENSVGLVKTKYVTFKDDFYFESGRILSPITVAYETYGKLNEKKDNAILICHALTGSAHAAGYNSPDDQKPGWWDDMIGPGKAFDTDKYFIICSNFLGSCYGTTGPASIDPSTGKPYGLKFPVFTVKDMVKLQKKLIDYLGIEKLLCVAGGSMGGMQALEWAVTFPEKTYSIIPIATAGRITPMAIAFNTIGRFAIMKDPNWMNGDYYGKTFPRDGLAIARMAGHITYMSDKSFHKKFGRRYATFGGIYDFFGYFEVENYLRYNGYKFTERFDANSYLYIIKAMDIFDLSYGYGSYEEAIGRIEADSLFITFTSDFLFPSYQTEEIVNIMKNHGKNPEWVNIESDYGHDAFLLEFDTQTSCIKEFLSKIYNKVANQ
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. MetX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYG_CHIRA
Sequence: MADFDMVLKCWGPMEADHATHGSLVLTRLFTEHPETLKLFPKFAGIAHGDLAGDAGVSAHGATVLNKLGDLLKARGAHAALLKPLSSSHATKHKIPIINFKLIAEVIGKVMEEKAGLDAAGQTALRNVMAIIITDMEADYKELGFTE
What is the function of this protein?
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
What are the official names of this protein?
Myoglobin.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: IRC19_KOMPG
Sequence: MSNGPAKYTIINRLVQPILPIKKQLLEENPNHSLRLLSLYRRHLRLRPFISPRADIKQFYTDLVRLRFKEDIELRRKHFTTPYTPLDKDSIIERVIRTLEIVNNGCVDSPNSIERQIIRNILDVEYANKNIKMVPLMSVEYFKEELWKGRELDVVSEPKLYDWVNKIDISNKSKKKNEQLNLLTALRNHYRSVASFNEVQKTLL
What is the function of this protein?
Involved in sporulation and maintenance of the mitochondrial DNA.  Is probably involved in a pathway contributing to genomic integrity (By similarity).
What are the official names of this protein?
Increased recombination centers protein 19.
What is the protein family that this protein belongs to?
Belongs to the IRC19 family.
Protein: RL19_BURCJ
Sequence: MNLIAKLEQEEIERALAGKTIPDFAPGDTVIVNVNVVEGNRKRVQAYEGVVIAIRNRGLNSNFIVRKISSGEGVERTFQTYSPLLASIVVKRRGDVRRAKLYYLRERSGKSARIKEKLVSKDRAAAASQE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: ALE1_YEAST
Sequence: MYNPVDAVLTKIITNYGIDSFTLRYAICLLGSFPLNAILKRIPEKRIGLKCCFIISMSMFYLFGVLNLVSGFRTLFISTMFTYLISRFYRSKFMPHLNFMFVMGHLAINHIHAQFLNEQTQTTVDITSSQMVLAMKLTSFAWSYYDGSCTSESDFKDLTEHQKSRAVRGHPPLLKFLAYAFFYSTLLTGPSFDYADFDSWLNCEMFRDLPESKKPMRRHHPGERRQIPKNGKLALWKVVQGLAWMILSTLGMKHFPVKYVLDKDGFPTRSFIFRIHYLFLLGFIHRFKYYAAWTISEGSCILCGLGYNGYDSKTQKIRWDRVRNIDIWTVETAQNTREMLEAWNMNTNKWLKYSVYLRVTKKGKKPGFRSTLFTFLTSAFWHGTRPGYYLTFATGALYQTCGKIYRRNFRPIFLREDGVTPLPSKKIYDLVGIYAIKLAFGYMVQPFIILDLKPSLMVWGSVYFYVHIIVAFSFFLFRGPYAKQVTEFFKSKQPKEIFIRKQKKLEKDISASSPNLGGILKAKIEHEKGKTAEEEEMNLGIPPIELEKWDNAKEDWEDFCKDYKEWRNKNGLEIEEENLSKAFERFKQEFSNAASGSGERVRKMSFSGYSPKPISKKEE
What is the function of this protein?
Broad specificity membrane-bound O-acyltransferase that mediates the incorporation of unsaturated acyl chains into the sn-2 position of various lysophospholipids.  Preferentially acylates lysophosphocholine (LPC), but also lysophosphoethanolamine (LPE), lysophosphatidylglycerol (LPG), lysophosphatidic acid (LPA), lysophosphoethanolamine (LPE), lysophosphoinositol (LPI), and lysophosphoserine (LPS) (PubMed:17996202, PubMed:17652094, PubMed:17726007, PubMed:17675291, PubMed:17890783).  Prefers an acyl residue to an alkyl residue at the sn-1 position of lysophospholipid acceptors.  Accepts acyl chains in acyl-CoA from C-2 to C-20, and shows strong preference for unsaturated acyl-CoAs with 16-20 carbons (PubMed:17890783).  Together with SLC1, plays a central role in phosphatidic acid (PA) biosynthesis.  PA is the intermediate, from which all glycerophospholipids are synthesized (PubMed:17890783).  Can also introduce an acyl chain at the sn-1 position of the lysophosphatidylcholine analog 1-hydroxy-2-hexadecyl-sn-glycero-3-phosphocholine (HHPC) (PubMed:29782033).
What are the official names of this protein?
Lysophospholipid acyltransferase, LPLAT, 1-acyl-sn-glycerol-3-phosphate acyltransferase, AGPAT, Lysophosphatidic acid acyltransferase, LPAAT, Lysophosphatidylcholine acyltransferase, LPCAT, Lysophosphatidylethanolamine acyltransferase, LPEAT, Lysophosphatidylserine acyltransferase, LPSAT, Sphingolipid compensation protein 4.
What is the protein family that this protein belongs to?
Belongs to the membrane-bound acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TVB65_HUMAN
Sequence: MSIGLLCCAALSLLWAGPVNAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVGAGITDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSY
What is the function of this protein?
V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).  Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.  Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).  Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.  In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.  The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462).  The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement.  This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells.  Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).
What are the official names of this protein?
T cell receptor beta variable 6-5.
What are the subcellular locations of this protein?
Cell membrane.
Protein: G3P_PANVR
Sequence: SKIGINGFGRIGRLVLRAALEMGAQVVAVNDPFIALEYMVYMFKYDSTHGMFKGEVKAEDGALVVDGKKITVFNEMKPENIPWSKAGAEYIVESTGVFTTIEKASAHFKGGAKKVIISAPSADAPMFVCGVNLEKYSKDMKVVSNASCTTNCLAPVAKVLHENFEIVEGLMTTVHAVTATQKTVDGPSAKDWRGGRGAAQNIIPSSTGAAKAVGKVIPELDGKLTGMAFRVPTPNVSVVDLTVRLGKECSYDDIKAAMKAASEGPLQGVLGYTEDDVVSCDFTGDNRSSIFDAKAGIQLSKTFVKVVSWYDNEFGYSQRVIDLIKHMQKVDSA
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, GAPDH.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REV1_SCHPO
Sequence: MAFNQRKRRRPVGIADFDEANDEAYESVGFHDYADYFSRKQRKLQNQNAALYKSIDEDSKSDLFHGLAIAINGYTKPSYTELRQMIVSNGGTFIQYVDGKTSISYLVCSFLTPSKARQWKHQKVVKPEWIVDCIKQKKILPWINYRTFQASSAQATLSFVASKPSQPEGNLEDIQTSSQEEEHDNEKDKTKESKAKGFLDDLSGLSASSLHNYQLLKNPNVRNSTTQNQDFLENFFSSSRLHHLSTWKADFKNEIQAMTTASEPVRPIMKDKSKKSRFLLHVDFDCFFASVSTRFSHELRLKPVAVAHGIKNSEIASCNYEARKFGIKNGMYVGTAKNLCPSLRVVDYDFGAYESVSREFYTILVNTLHDYIKVISIDEALLDITSSVSSFQDCFEIAESIRSQVREKTNCEVSVGIGPNVLLARLALRKAKPHNVYSLSIENVFDVLSPLSVQDLPGVGSSQAQKLFNLYGVRTIGQLQRIEKFNLQETFGVNYGLHLYNISRGIDTDIINNETPRRSISVDVNWGVRFVFQEDGIDFLKRLLHELLSRMGKCQVLLHQIQLRILKRADGAPFSPPKYLGAGEVTSFTKSSTFTSATNSFDLIWKKVTSMYKTINVDPGDVRGIGLQALKIIKDNSKIRKDYRSIQSITSRNKVSLKGASVDISSKDKEIISQKKQLSPKLIPSTPYDLPSSSQISSSALAQLPPSMQSDIQQQLRLQKRSITEYPSQLDPLFMVELPTPIRNEVNDNHEIAMNKRLSLKSHADNKIDERGKKKIRQENAFDKLLQISKKSKTINKPNVDYLTLKELPKDLQKQILKESNLQKSDLISEVKLEKPHIVTFQHVQSLEDLRGLLTKWYSKASKGPNIHDVNYFANYVCRVIREEKNLGKAQMMLKWLYQLNRKECNKPWEKAIDKIIETVQGECLQRNIPPLMIF
What is the function of this protein?
Deoxycytidyl transferase involved in DNA repair.  Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction.  May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion.  Required for normal induction of mutations by physical and chemical agents.  Involved in mitochondrial DNA mutagenesis (By similarity).
What are the official names of this protein?
DNA repair protein rev1, Reversionless protein 1.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Mitochondrion. Cytoplasm, cytoskeleton, spindle.
Protein: LEA2_ARATH
Sequence: MARSLANAKIQSVFGSEKLSNAVFRRGFAAAAKTALDGSVSTAEMKKRAGEASSEKAPWVPDPKTGYYRPETVSEEIDPAELRAILLNNKQ
What are the official names of this protein?
Late embryogenis abundant protein 2.
What is the protein family that this protein belongs to?
Belongs to the LEA type 3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: HFQ_BREBN
Sequence: MKQTINIQDTFLNHLRKENIAVTIYLVNGFQLRGYIKAFDNFTIVIDSEGKQQLVYKHAISTFTPQRPVSLMSQENNQQ
What is the function of this protein?
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations.  Also binds with high specificity to tRNAs.
What are the official names of this protein?
RNA-binding protein Hfq.
What is the protein family that this protein belongs to?
Belongs to the Hfq family.
Protein: CSPL1_PINCO
Sequence: MNVSHPAVHPVGVPPALGGQAVPPRMRMRVRMEYLVFQGMPLPGSLGGLMLRLGQFCSALIAFSVMVSIRDFSVTAFCYLLAATVLQCLWSLALAVIDVYALLVKRSLRNPLLVSIFVVGDGVTATLTFAAACASAGVVVLIGNDISMCKSNPCANYEAAIIMAFLSWFMVSISFVLTFWMLATL
What are the official names of this protein?
CASP-like protein 5A1, PcCASPL5A1.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.