PharMolix/UniProtQA huggingface dataset:
Protein: U5S1_HUMAN
Sequence: MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHIVDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTFGDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKILAQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFVDMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKMYSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLWISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLKFNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNKKNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCDELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPYYFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAREFMIKTRRRKGLSEDVSISKFFDDPMLLELAKQDVVLNYPM
What is the function of this protein?
Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154).  Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
What are the official names of this protein?
116 kDa U5 small nuclear ribonucleoprotein component, Elongation factor Tu GTP-binding domain-containing protein 2, SNU114 homolog, hSNU114, U5 snRNP-specific protein, 116 kDa, U5-116 kDa.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
Protein: VP6_LDCPR
Sequence: MFAIDPLKHSKLYEEYGLYLRPHQINQEIKPTTIKKKELAPTIRSIRYASLLHSMLAKHAARHNGTLINPRMYADMITLGNTKVTVTKGTPKAQIDTLKMNGLTVVSKSRRNNKKKPVSDTTATTDENTNDIVTYKALTEMSTLVESFHLPSGLTLIVFDDEKYQSLIPDYINQLITYTQPHIIPTWQGIADFSDPYLRSYFRRPFELTASNLASPQKHNLSPLTRSIFNNTGREDAIIKKLYGYGEYIFIKYEGCLITWTGVYGAVAMMVNLPKRDLGLDAGDNFLKEYKQLLFYGVITDATPSGISAKSTVIKISPHKMMNPSGGALAVLSKFLEAVVSANVINATLVVYAEKGAGKTSFLSTYAERLSVASGQAVGHLSSDAYGRWLAKNKDVKEPSFEYDYVLSRDTDDTESYYEQRASELLTLHGISELAQYELLSVRKKVKMMNEMNEILIAQLENADTHSERNFYYMVSTGKNTPRTLIVEGHFNAQDATIARTDTTVLLRTINDTTQAMRDRQRSGVVQLFLRDTYYRLLPSLHTTVYPFEMLESIKRWKWVH
What is the function of this protein?
Minor inner capsid component.  Displays NTPase and RNA 5'-triphosphatase (RTPase) activities.  May function as a cofactor of polymerase VP2.  Associates with microtubules and plays a role in the formation, structural organization and morphology of viral inclusions, where the assembly of cores and the replication of viral RNA occur (By similarity).
What are the official names of this protein?
Microtubule-associated protein VP6.
What are the subcellular locations of this protein?
Virion. Host cytoplasm, host cytoskeleton.
Protein: THA8_ARATH
Sequence: MALSLSQTRPPSLSHSHTLSVIVPKRTFVSIRCGPRDNRGPLLKGRILSTEAIQSIQSLKRAHRTGVSLSLTLRPLRRLIKSDLISVLRELLRQDYCTLAVHVLSTLRTEYPPLDLVLYADIVNALTRNKEFDEIDRLIGEIDGIDQRSDDKALAKLIRAVVGAERRESVVRVYTLMRESGWGSESWEADEYVAEVLSKGLLRLGEPDLASQVSLKSSILKP
What is the function of this protein?
Essential protein required during embryogenesis (PubMed:15266054, PubMed:22495966).  Mediates group II organellar RNA introns splicing (e. g.  ycf3-2 and trnA) (PubMed:22495966).  Binds weakly to specific RNA (PubMed:22495966, PubMed:24047899).  Promotes the biogenesis of chloroplast thylakoid membranes (PubMed:22495966).
What are the official names of this protein?
Protein THYLAKOID ASSEMBLY 8, chloroplastic, At-THA8, AtTHA8, Protein EMBRYO DEFECTIVE 3123.
What is the protein family that this protein belongs to?
Belongs to the PPR family. P subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side.
Protein: SAP18_DROME
Sequence: MANVESMIVEEKTQVKQIDREKTCPMLLRVFCSTGRHHSVSEYMFGNVPTNELQIYTWQDATLHELTSLVRDVNPDTRKKGTYFDFAVVYPNFRSNHFQMREIGVTCTGQKGIDDNKTLAQAKFSIGDFLDISITPPNRLPPTARRQRPY
What is the function of this protein?
Involved in the tethering of the SIN3 complex to core histone proteins.  Interacts with bicoid (bcd) to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction.  Interacts with Trl and binds to Polycomb response elements at the bithorax complex.  May contribute to the regulation of other homeotic gene expressions.
What are the official names of this protein?
Histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, Bicoid-interacting protein 1, dSAP18.
What is the protein family that this protein belongs to?
Belongs to the SAP18 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
Protein: ARY_GALME
Sequence: MQTVLFLAALVSLAAAGYPQYHYDVETRKLDPSLLNIQTKVLSLLENWKQVNPDDEYYKIGKEYNVEANMESYTNREVVTEFLSLYKAGFIPKNEVFSIFYENQALEVIALYRLFYYAKDFETFYKTAAFARVWLNEGQFVYAFYLAVIHRADTRGIVLPAPYEIWPEYFMNSDVLSKIYRIQMQKGLIIPEQGPYYGILSKDNAYYFYANYSGPLTYEDNENLLSYFIEDIGWNSYYYYFHNRFPFWENGEQLIGPLKERRGEIYYYVYQKILARYYLERLANGLGEIPRFNWLDKYQTSYYPLLSSYQLPFAQRNDDYYLASGDNINDIQFIDTYEKTFLQLLQKGQFKAYKQEVDLYNSKSINFVGNYWQSNADLYEKVPKRNYWRSYEATARRVLGAAPRSSINYENMNIPTALDFYQTSLRDPAFYQLYAKILDYINEYKEYLEPYSQDVLHYVGVKINDVKVDKLVTYFEYFDWNATNAVYLSEQQLDTVSPSYIVRQPRLNNKPFTVNIDIKSDVESEVVVKIFLGPKYDGNGLPISLEDNWINFIELDWFTHKLTSGQNKIARKSEEFFFFKDDSVSLFKIYELLSNGQVPSYMVDRYIYLPRRLILPRGTQRGFPLQLFVVVYPYQAPVKEWESMRQYIVDNKPFGYPFDRPVTLPYYFNQPNMYFKDVYVYQEGEQYPYYNSYWSQNQVSNH
What is the function of this protein?
Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins (Probable).  Binds the A. niger cell wall component alpha-1,3-glucan, a fungal pathogen-associated molecular pattern (PAMP) that activates the host immune response (PubMed:34443685).
What are the official names of this protein?
Arylphorin, Lhp76.
What is the protein family that this protein belongs to?
Belongs to the hemocyanin family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted in the hemolymph.
Protein: MIAB_CLOBH
Sequence: MNEILNTKDINVIGEFFIETWGCQMNEEDSEKLSGMLKKEGYIRTEERENADVIIFNTCCVRENAELKVYGNLGILKGLKSKNPNLIIAVTGCMMQQKGMAETIKKKFPFVDIIIGTHNLHNFPNYLNEVKKKDTSVLKIQEKENSIIENMPIDRKNSMKAFVTIMYGCNNFCTYCIVPYVRGRERSRTPENIEAEIKKLISEGYKEITLLGQNVNSYGKDLEPNVTFAELLKRVNNIEGLERVRFMTSHPKDLTDDVIEAIAKCDKLCEQIHLPVQSGSSEILKKMNRHYDREKYLDVVSKIKKLIPNVALSTDIIVGFPGETEKDFEETLSLVKEVEYDSAFTFLYSIRKGTPAAKFEDQVPEDVKHKRFNRLVEVLNEISAKKNKAYEGKIEEVLVEGTSKNDENKLMGRTRTGKLVNFIGDKDSIGELVNVKIIKANSFSLTGEEI
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CNTA_ACIB2
Sequence: MSAVEKLPEDFCANPDVAWTFPKVFYTSSQVFEHEKEAIFAKSWICVAHSSELAQPNDYITRKVIGENIVIIRGKDSVLRAFYNVCPHRGHELLSGSGKAKNVITCPYHAWTFKLDGSLALARNCDHVESFDKENSSMVPLKVEEYAGFLFINMDENATCVEDQLPGFAERLNQACGVIKDLKLAARFVTETPANWKVIVDNYMECYHCGPAHPGFADSVQVDKYWHTTHQNWTLQYGFARSSEKSFKLDPSVTDPEFHGFWTWPCTMFNVPPGSNFMTVIYEFPVDAETTLQHYDIYFTNEELTQDQKDLIEWYRNVFRPEDLNLVESVQRGLKSRGYRGQGRIMTDKQRSGISEHGIAYFQHLVAQYHQ
What is the function of this protein?
Converts carnitine to trimethylamine and malic semialdehyde.
What are the official names of this protein?
Carnitine monooxygenase oxygenase subunit, Carnitine monooxygenase alpha subunit.
What is the protein family that this protein belongs to?
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily.
Protein: SAM5A_XENLA
Sequence: MGTVHARSLDPLPMNGPDFGSPDDADLVEVEPQKKQEILENKDVVVQRVHFEGLGRTKDDLVAHEIGQVFKAKNLIEVMRKSHEAREKLLRLGVFRNVEVLIDTCEGEDAVPNGLDVTFEVTELRRVTGSYNTMVGNNEGSMVLGLKLPNLFGRAEKMTFQFSYGTKETSYGLSFFKPQVGNFERNFSVNLYKVTGQFPWSSLRETDRGVSAEINFPIWKTSHTLKWEGVWRELGCLARTASFTIREESGHTLKSSLSHSMVIDSRNASILPKSGALLKINQELAGYTGGDVSFLKEDFELQLNRQLTWDSVLSTSLWGGMLVPIGDRPSSIADRFYLGGPTSVRGFSMYSIGPQSEGDYLGGEAYWAGGVHLYTPLPFRPGRGGFGDLFRTHFFLNAGNLCNLNYGEGPGAHLRRLAECIRWSYGAGLVLRLGNIARLELNYCIPMGVQSGDRICDGVQFGAGIRFL
What is the function of this protein?
May play a role in the maintenance of the structure of mitochondrial cristae.
What are the official names of this protein?
Sorting and assembly machinery component 50 homolog A.
What is the protein family that this protein belongs to?
Belongs to the SAM50/omp85 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: TRMFO_AZOC5
Sequence: MSQTSLQPVHVVGGGLAGSEAAFQLAERGVPVVLHEMRPVRGTEAHHTDGLAELVCSNSFRSDDAQTNAVGVLHAEMRRAGSLILRCADANQVPAGGALAVDRDGFSQAVTAALAEHPLVEIRREEVTAIPPEEWDNVIIATGPLTSPALAQAVLELTGESALAFFDAIAPIVHLDSIDLSKAWFQSRYDKVGPGGTGADYINCPLDKEQYEAFVDALLASEKVPLRDFEAKTPYFDGCLPIEVMAERGRETLRFGPLKPVGLTNPHNPDVKPHAVIQLRQDNKLGTLYNLVGFQTKMRHGEQVRVFRTIPGLENAEFARLGGLHRNTYLNSPRLLDGTLRLKAAPRLRFAGQITGCEGYVESAAVGLMAGRFAAAERRGEALVPPPATTAHGALLAHITGGHIETVDAGPRSFQPMNVNFGLFPQLDVSPKGADGKRLRGSEKTLAKKRLLAERALSDMSAWLDTPAAAA
What is the function of this protein?
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
What are the official names of this protein?
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO, Folate-dependent tRNA (uracil-5-)-methyltransferase, Folate-dependent tRNA(M-5-U54)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MnmG family. TrmFO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_RHOOB
Sequence: MSTPASAAPAALVRVPAGTTAGTAVREAGYPSKGPDVVVVVRDAEGGLRDLSWVPDADVDVEPVAANTDDGRSVIRHSAAHVLAQAVQQEFPEAKLGIGPPIKDGFYYDFAVERPFTPEDLANLEKRMKKIVKGSQRFSRRVVDSLEEARAELANEPFKLELIDDKSGIDDPEIMEVGGNELTIYDNLDPRTGEKVWGDLCRGPHIPTTKHIPAFKLTRSSAAYWRGNQDNADLQRIYGTAWESAEAQEQHLELLAEAERRDHRKLGSELDLFSFPDELGSGLPVFHPRGGIIRTEMEDYSRKRHVEEGYEFVNTPHITKGHLYEVSGHLDWYRDGMFPAMHIDEELNEDGTVRKPGQDYYLKPMNCPMHNLIFRSRGRSYRELPLRLFEFGSVYRYEKSGVVHGLTRVRGMTQDDAHIYCTREQMRDELATTLQFVLGLLKDYGLDDFYLELSTKNPDKFVGDDAVWEEATATLAEVAESSGLNLVPDPGGAAFYGPKISVQVQDALGRTWQMSTIQLDFNLPERFDLEYTASDGTKKRPVMIHRALFGSIERFFGVLTEHYAGAFPAWLAPVQVVGIPVAETFADHLFDVVKRLKAAGVRAEVDASDDRMQKKIFNNTAQKVPFMLLAGARDVEAGAVSFRFRDGTQVNGVPVDDAVRIVTDWIGRRENASPTAELLQSGREG
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ORSB_EMENI
Sequence: MTPPLLALEEHYYSTAIFNSIGETFQRTLQGVPGLADQLRSLGDGRLEAMNRGNISLQVVSHAFTPGGPSAEACRAGNDELAAEIAQISDPQRFAAFAVLPVADPTASAAELDRSVSELGFVGALIDNHADGKHFDGHDYDVLWAKACELDVPIYLHPTWPSARMAENFMGSYPVPVGISLGGPGWGWHPDVGLHVLKLFAAGVFDRFPRLKIIVGHMGEMLPYMLERASDMSTRWGGWGPRDRPLRQVWDENIWITTSGSWSLAPLKCILHNTKVERIMYSVDYPFESNERGLEWFKELEGSGLLTEEQLEMVAYRNAEDLLKVHMKKEQ
What is the function of this protein?
Decarboxylase; part of the gene cluster that mediates the biosynthesis of orsellinic acid, as well as of the cathepsin K inhibitors F9775 A and F9775 B (PubMed:19666480, PubMed:20174687).  The non-reducing polyketide synthase orsA produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units (PubMed:19666480, PubMed:20174687).  Further modifications by the decarboxylase orsB and the tyrosinase-like protein orsC lead to the production of F9775 A and F9775 B (PubMed:20174687).  The functions of orsD and orsE remain unclear since only orsB and orsC are required to convert orsellinic acid into F9775 A and F9775 B (PubMed:20174687).
What are the official names of this protein?
Decarboxylase orsB, Orsellinic acid/F9775 biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
Protein: PEPA4_HUMAN
Sequence: MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA
What is the function of this protein?
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
What are the official names of this protein?
Pepsin A-4, Pepsinogen-4.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RF3_STAEQ
Sequence: MNLKEEIESRKTFAIISHPDAGKTTLTEKLLYFSGAIREAGTVKGKKTGKFATSDWMKVEQERGISVTSSVMQFDYDDYKINILDTPGHEDFSEDTYRTLMAVDSAVMVIDCAKGIEPQTLKLFKVCKMRGIPIFTFINKLDRVGKEPFELLDEIEETLNIDTYPMNWPVGMGQNFFGIIDRHSKTIEPFRDEENLLHLNEDYELKEEHAIKNDSAFEQAIEEMMLVDEAGEAFDNEALLNGELTPVFFGSALANFGVQNFLNAYVDHAPMPNARQTKEEVDVSPFDTDFSGFIFKIQANMDPKHRDRIAFMRVVSGAFERGMDVTLQRTNKKQKITRSTSFMADDKETVNHAVAGDIIGLYDTGNYQIGDTLVGGKQKYSFQELPQFTPEIFMKVSAKNVMKQKHFHKGIEQLVQEGAIQYYKTLHTNQIILGAVGQLQFEVFEHRMNNEYNVDVVMEPVGRKIARWIENEEDIKDNMNTSRSILVKDRYDNYVFLFENEFATRWFEEKFSDIKLYSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABP9_CAEEL
Sequence: MLSAFFKTAHCALRNMPIQTDLVGKWNFVSSENFDEYLKEVGVGWAIRTIATKTKPALEFAVNGDEWTMNSNSTFKNYTLKWKLGTASDEKTADGRDVSSVFSIENDHLVQIETGKGGGKDSRIERYIENGKLVIVCTCNGVKCTRVYEKAA
What are the official names of this protein?
Fatty acid-binding protein homolog 9.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Protein: MOCS3_DROVI
Sequence: MIAAANCLETEKAKLRREIAELQAALNAKEQNLRDLQSRTAASHLDPEADLQHATREQYATLNNDDIARYSRQLILSDFGVSGQLKLKNSAVLIVGLGGLGCPAAQYLCSAGCGNLGLVDYDEVERSNLHRQTLHTVARCGMSKTESARIALLELNPHCRITCYPRLLNSSNAMHIMRAYDIVLDCSDNVATRYLLNDACTMLRKPLVSGSALKLDGQLTVYSYGAQGPCYRCIYPVPPPPEAVTNCGDGGVLGAVTGTIGAMQALEAIKIIIGLGDVLAGRMLIFDGSSCQFRNIKIRSKRPNCHVCSAQPLITGLIDYELFCGMNANDKDNAVKLLEPEERINVLDYQRLMKTKAHLLLDVRAPAEFEICQLPDSINVPLAHVLDDSYLQRFAQQLESKELPIFVVCRRGNDSQIAVQHMRTRLPEHSIRDLEGGLHAWTNQVDQSFPIY
What is the function of this protein?
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln).  Also essential during biosynthesis of the molybdenum cofactor.  Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A.  Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus.  The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A.  Subsequently, a transient disulfide bond is formed.  Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
What are the official names of this protein?
Adenylyltransferase and sulfurtransferase MOCS3, Molybdenum cofactor synthesis protein 3, Ubiquitin activating enzyme 4.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LFTR_RHIWR
Sequence: MKAIDPDLLLRAYSIGVFPMADSRAADDVYWVEPKKRGILPLDHFRLSRSLAKTIRSDRFAVTADRAFGEVVAECAAVTSQRPDTWINPAIEAAYADLHRRGHAHSIECWREGRLVGGLYGVRLGGAFFGESMFSRESNASKVALAWLVARLRAGGFRLLDCQFITDHLQSLGAIEVSRDDYVALLDVALGVVAGAGAAGGVAVAGAAAGWSAPDFFALDGGATDPDTRTVSGPISGCTIVQLLGQTS
What is the function of this protein?
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
What are the official names of this protein?
Leucyl/phenylalanyl-tRNA--protein transferase, L/F-transferase, Leucyltransferase, Phenyalanyltransferase.
What is the protein family that this protein belongs to?
Belongs to the L/F-transferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPE_NEOSM
Sequence: MLTLRAPAKINLFLLITGRNESGFHLLDSVFCFTHDLYDEIIIVPTSATENSVKFIGASQAIGADNSVSRVLRFVNDYAKRYFNVTLVKNLPVAAGIGGGSADAAALLRYFGGLHNISEVLLSQVALSVGFDTLACLYSHPCHVTGMGEKIVALPESKLVYPILLVCPNFPVSSAEVYKNFRERRSIFSAESNLAGDHQAFEDMLSLPNDLTDAAIEIAPVISDVLKSIKNCKGNKVTKLCGSGPTCIGVFDTVENLRDAHSELIRHHKWWVKIAHISL
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: YO093_YEAST
Sequence: MDFSIPPTLPLDLQSRLNELIQDYKDENLTRKGYETKRKQLLDKFEISQMRPYTPLRSPNSRKSKHLHRRNTSLASSITSLPNSIDRRHSIYRVTTINSTSANNTPRRRSKRYTASLQSSLPGSSDENGSVKDAVYNPMIPLLPRHTGAENTSSGDSAMTDSLPLILRGRFEHYDGQTAMISINSKGKETFITWDKLYLKAERVAHELNKSHLYKMDKILLWYNKNDVIEFTIALLGCFISGMAAVPVSFETYSLREILEIIKVTNSKFVLISNACHRQLDNLYSSSNHSKVKLVKNDVFQQIKFVKTDDLGTYTKAKKTSPTFDIPNISYIEFTRTPLGRLSGVVMKHNILINQFETMTKILNSRSMPHWKQKSQSIRKPFHKKIMATNSRFVILNSLDPTRSTGLIMGVLFNLFTGNLMISIDSSILQRPGGYENIIDKFRADILLNDQLQLKQVVINYLENPESAFSKKHKIDFSCIKSCLTSCTTIDTDVSEMVVHKWLKNLGCIDAPFCYSPMLTLLDFGGIFISIRDQLGNLENFPIHNSKLRLQNELFINREKLKLNEVECSITAMINSSSSFKDYLKLETFGFPIPDITLCVVNPDTNTLVQDLTVGEIWISSNHITDEFYQMDKVNEFVFKAKLNYSEMFSWAKYEMPTNEKSQAVTEQLDTILNICPANTYFMRTKLMGFVHNGKIYVLSLIEDMFLQNRLIRLPNWAHTSNLLYAKKGNQSAQPKGNTGAESTKAIDISSLSGETSSGYKRVVESHYLQQITETVVRTVNTVFEVAAFELQHHKEEHFLVMVVESSLAKTEEESKNGETTDTTLMKFAETQRNKLETKMNDLTDQIFRILWIFHKIQPMCILVVPRDTLPRRYCSLELANSTVEKKFLNNDLSAQFVKFQFDNVILDFLPHSAYYNESILSEHLSKLRKMALQEEYAMIEPAYRNGGPVKPKLALQCSGVDYRDESVDTRSHTKLTDFKSILEILEWRISNYGNETAFSDGTNTNLVNSSASNDNNVHKKVSWASFGKIVAGFLKKIVGSKIPLKHGDPIIIMCENSVEYVAMIMACLYCNLLVIPLPSVKESVIEEDLKGLVNIIQSYKVKRVFVDAKLHSLLNDNNVVNKCFKKYKSLIPKITVFSKVKTKNALTVSMFKNVLKQKFGAKPGTRIGMTPCVVWVNTEYDVTSNIHVTMTHSSLLNASKIVKETLQLRNNSPLFSICSHTSGLGFMFSCLLGIYTGASTCLFSLTDVLTDPKEFLIGLQNLNVKDLYLKLETLYALLDRASSLIEGFKNKKENINSAKNNTSGSLREDVFKGVRNIMIPFPNRPRIYTIENILKRYSTISLSCTQISYVYQHHFNPLISLRSYLDIPPVDLYLDPFSLREGIIREVNPNDVSAGNYIKIQDSGVVPVCTDVSVVNPETLLPCVDGEFGEIWCCSEANAFDYFVCNSSKNKLYKDPFITEQFKSKMKSEVNNTLSYLRTGDLGFIKNVSCTNSQGEVVNLNLLFVLGSIHESIEILGLTHFVSDLERTVKDVHSDIGSCLIAKAGGLLVCLIRCKERHNPILGNLTTLIVSELLNKHGVILDLCTFVRTKGISPKNSSMIMEVWAKNRASIMQAWFDQKIQIEAQFGINYGENISIYLLSDYEKDNI
What are the official names of this protein?
Uncharacterized protein YOR093C.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ACHA4_MUSPF
Sequence: MELGGPGAPPPPLLPPLLLLLGAGFLPASSPVETRAHAEERLLKTLFSGYNKWSRPVANISDVVLVHFGLSIAQLIDVDEKNQMMTTNVWVKQEWYDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAITHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMQSHVDQLGLWESGEWVIVDAAGTYNTRKYECCAEVYPDITYAFVIRRLPLFYTINLIVPCLLISCLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMVFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDVVPRLLLMKRPSVVKDNCRRLIESMHKVASAPGFWPEPEGEPGVVSGERSRGPSRSASFRGPRDEPAEPQPACASPSDRVPAPQPSEGDPGSPCPLPDSCRPPPSTRAPGLTEARSLSFQHVSSAAERVEGGVRCRSWSIQGCAPQDEAASVAGGPVTSSPAFPKASAAELLPPDQPSPCRCRCRKEPSPNAVRKACGTRVPARHLPLSPALARAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWVFVIVCLLGTAGLFLPPWLAGMI
What is the function of this protein?
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
What are the official names of this protein?
Neuronal acetylcholine receptor subunit alpha-4.
What is the protein family that this protein belongs to?
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
What are the subcellular locations of this protein?
Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Lipid-anchor. Cell membrane; Multi-pass membrane protein.
Protein: NAGK_ECOSE
Sequence: MYYGFDIGGTKIALGVFDSGRQLQWEKRVPTPRDSYDAFLDAVCELVAEADQRFGCKGSVGIGIPGMPETEDGTLYAANVPAASGKPLRADLSARLDRDVRLDNDANCFALSEAWDDEFTQYPLVMGLILGTGVGGGLIFNGKPITGKSYITGEFGHMRLPVDALTMMGLDFPLRRCGCGQHGCIENYLSGRGFAWLYQHYYHQPLQAPEIIALYDQGDEQARAHVERYLDLLAVCLGNILTIVDPDLVVIGGGLSNFPAITTQLADRLPRHLLPVARVPRIERARHGDAGGMRGAAFLHLTD
What is the function of this protein?
Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.
What are the official names of this protein?
N-acetyl-D-glucosamine kinase, GlcNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NagK subfamily.
Protein: TSAD_BRUA2
Sequence: MRVLGIETSCDETAAAIVERDDMGEGRILSNVVLSQIAEHEPYGGVVPEIAARAHVEALDRLVDRALNDAGLKLYEVDAVAATAGPGLIGGLIVGLMTAKALAMAAQKPFYAVNHLEGHALTARLTDGLPFPYLLLLVSGGHTQMVLVRGIGDYERLGTTIDDALGEAFDKTAKLLGLPYPGGPTVERMALQGDQKRFALPRPLKGEARLDFSFSGLKTAVRQTATELVPLTDQDVTDICASFQAAVADTLSDRVGRSLERFKTEFPDCATPSLVVAGGVAANKTLRAALENLCTRHGFAFIAPPLNLCTDNAAMIAWAGAERAATQAPDSLDIAPRSRWPLDEKSAPVFGTGRRGAKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.