PharMolix/UniProtQA huggingface dataset:
Protein: RARA_TAKRU
Sequence: MAGKGNPVPGPHLNGFPVPTYSYFFPHMLGSLSPPALPGLPISGYSTPSPATIETQSTSSEEIVPSPPSPPPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHREKNCIINKVTRNRCQYCRLQKCLEVGMSKESVRNDRNKKKKDEKKPECIENYVLSPDTEQMINRVRKAHQETFPSLCQLGKYTTTNSSERRVALDVDLWDKFSELSTKCIIKTVEFAKQLPGFVTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLLCGDRQDLEQAEKVDILQEPLLEALKIYVRRRRPHKPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLESGATGSRPSGAPPGSCSPSLSPSSAQSSPPTQSP
What is the function of this protein?
Receptor for retinoic acid.  Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes.  The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity).
What are the official names of this protein?
Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCSPB_BACCQ
Sequence: MKNQDQALIFEVSKEGRIGYSLPKLDVEEVKLEDVFESDYIRVEDAELPEVSELDIMRHYTALSNRNHGVDSGFYPLGSCTMKYNPKINESVARFAGFANIHPLQDEKTVQGAMELMYDLQEHLIEITGMDTVTLQPAAGAHGEWTGLMLIRAYHEANGDFNRTKVIVPDSAHGTNPASATVAGFETITVKSNEHGLVDLEDLKRVVNEETAALMLTNPNTLGLFEENILEMAEIVHNAGGKLYYDGANLNAVLSQARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKADLIPYLPKPILEKTENGYHFNYDRPEAIGRVKPFYGNFGINVRAYTYIRSMGPDGLRAVTEYAVLNANYMMRRLAPFYDLPFDRHCKHEFVLSGRRQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDGFIDKMIQIAKEVEENPEVVQEAPHTTVIKRLDETMAARKPVLRYEKPAPVQV
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 2, Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. C-terminal subunit subfamily.
Protein: SYT_CHLTE
Sequence: MSEITDDRQQVIITLPDGSERTYSSGVTGLEIAESIGKKLAEAALAFTIDGKPRDLDTPVTENARVSIITFDSPEGKEIFWHSSSHLMAHAIEELFPGAKFGAGPAIEQGFYYDIACEHRFNEEDLRAIEAKMLEISKRNLSINREEMPREQAIEYFSNERKDPYKVEILEDTLKDVPTVSVYHQDGFADLCSGPHLPSTGKVKAVLLTNISSSYWRGDSSRETMQRIYGITFPSDKLLKEHIARLEEARKRDHRKLGAELGLFMLTPEVGSGLPIWLPNGAIIRNELETFLKAEQRKRGYVPVYTPHIGNIELYKRSGHYPYYSDSQFPPLTYKDETGREEQYLLKPMNCPHHHLIYSQTLRSYRDLPIRLTEFGTVYRHEQSGELNGLVRARGFTQDDSHIYCRPDQLVDEICNAIDLTRFVFNTLGFDEVETRLSLHDPENQSKYGGTAEVWGQAEKDVKEAADRMGIKYFIGIGEASFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQKHRPVVIHRAPFGSMERFIGVLIEHTAGNFPLWLAPVQAVVLPIAEEVHDYAREVYAKLHEAGIRTELDLRSEKIGKKIREAELSKIPAMLVIGRNEQEKGEVSLRRHRKGDEGSFGVDELIARLCEERDRRF
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F16PA_VIBCM
Sequence: MQKMRTLGEFIVEKQHDFPHASGELSSLLASIRLAAKIVNREINKAGLADIIGASGNDNIQGEEQQKLDLYANEKFKAALEARDQVCGVASEEEDEAVAFSKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVSPVGTPPTQEDFLQPGNKQVAAGYVIYGSSTMLVYTTGNGVNGFTYDPSLGTFYLSHENMRIPENGKIYSINEGNYIRFPTGVKKYIKFCQENVPEEGRPYTSRYIGSLVADFHRNLLKGGIYLYPSTQSHPNGKLRLLYECNPMAFLIEQAGGLASDGARRIMDIKPTELHQRVPFFVGSKNMVHKVETFLETYPD
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEPA_SHISS
Sequence: MNKTAIALLALLASSASLAATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYFGHPDLVMFIQRLSSQVSNLGMGTVLIGDMGMPAGGRFNGGHASHQTGLDVDIFLQLPKTRWTSAQLLRPQALDLVSRDGKHVVSTLWKPEIFSLIKLAAQDKDVTRIFVNPAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPSGDGCGAELQSWFAPLKPGTTKPEKKTPPPLPPSCQALLDEHVI
What is the function of this protein?
Murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino-pimelyl amide bond that connects peptidoglycan strands.  Likely plays a role in the removal of murein from the sacculus.
What are the official names of this protein?
Penicillin-insensitive murein endopeptidase, D-alanyl-D-alanine-endopeptidase, DD-endopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M74 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: TSKS_RAT
Sequence: MASVVVKTIWQSKEIHEAGDPPAGVESRAQLVPEAPGGVTSPAKGITKKKKAVSFHGVEPRMSHEPMHWCLNLKRSSACTNVSLLNLAAMEPDSSGTDSTTEDSGPLALPGPPASPTTPWAPEDPDITELLSGVNSGLVRAKDSITSLKEKTTRVNQHVQTLQSECSVLSENLERRRQEAEELEGYCSQLKGPRPDVLTQENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQELEQKLEAGLSRHGLGPTTPIQGCSGPPGSPEEPPRPRGLPSNGWGMAIRAGEGPSLSEQELQKVSSGLEELRREVSSLAARWHQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQSARGLQELRGRADELCTMVERSAVSVASLRSELEALGPVKPILEELGRQLQNSRRGPDHVLNLDRPAQGPCPRCASQGQQLSTESLQQLLERALTPLVDEVKQKGLAPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEAVRAKNLLLTDKMKPEEKVATLDYMHLKMCSLHDQLSHLPLEGSTGAMGGGSTGGAPPKRGGPGSEQ
What is the function of this protein?
May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
What are the official names of this protein?
Testis-specific serine kinase substrate, Testis-specific kinase substrate, STK22 substrate 1.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrates in spermatid centrioles during flagellogenesis.
Protein: SYE_MYCUA
Sequence: MTSSSVRVRFCPSPTGIPHVGMVRTALFNWAYARHTGGTFVFRIEDTDAARDSEESYLALLDALRWLGLDWDEGPEVDGPYGPYRQSQRTEIYHDVVAKLLTAGEAYYAFSTPEEVEARHIAAGRNPKLGYDNFDRQLTDSQRAAYLAEGRKPVVRLRMPDTDLAWHDLVRGPTTFAAGSVPDFALTRATGDPLYTLVNPCDDALMKITHVLRGEDLLPSTPRQIALYQALMCIGIAERVPEFAHLPTVLGEETKKLSKRDPQSNLFAHRDRGFIPEGLLNYLALLGWAIADDHDLFSLDEMVAAFDVADVNSNPARFDQKKADAINAEHIRMLDVADFTARLRAYLDTHGHQLALDDAAFAVAAELVQTRIVVLEDAWALLKFLNDDRYAIDPKAAAKELGPDAGPVLDAAIAALDGAADWTTADIEAALKTALIGGMALKPRKAFGPIRVAATGTTVSPPLFESLELLGRERSLGRLRSARDQVGSP
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM3_SULIA
Sequence: MKIRIAARGSKLSRIQVDMLGEKLKKIGIEYEIIDIKTKADLFSTEPLSKLGKGVFEKEVNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEKNLDKLDSNITIGTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYHRLNVYDFTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHSPIGVLFKKEGKEFYGIASYSDGKKKITVSISKPGDPYTIGSELGLLLKKEMKNENIIP
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Probable porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: CSK2A_DROME
Sequence: MTLPSAARVYTDVNAHKPDEYWDYENYVVDWGNQDDYQLVRKLGRGKYSEVFEAINITTTEKCVVKILKPVKKKKIKREIKILENLRGGTNIITLLAVVKDPVSRTPALIFEHVNNTDFKQLYQTLTDYEIRYYLFELLKALDYCHSMGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELYAYLDKYNIDLDPRFHDILQRHSRKRWERFVHSDNQHLVSPEALDFLDKLLRYDHVDRLTAREAMAHPYFLPIVNGQMNPNNQQ
What is the function of this protein?
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.  The alpha chain contains the catalytic site.  May participate in Wnt signaling.
What are the official names of this protein?
Casein kinase II subunit alpha, CK II subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: STS1_DEBHA
Sequence: MMSTGFSWGTQALSESTEVNSGLGDLPTSIPRYTPNLKPVNNNHHSNGKKRRYSEDQESKVVKPTGNRKHYTTPSTYYKSKKSRTPKIMGQKLPINRLVEALDHTSLQRLLESLIHEHPEISNTIDKISPKPTLTDSIELIKQKFNSIMHHLPYKCDTESDYSYLRIKTHLNEFLNCLSDFILNFLPPIETNVFNSLKFLDEVTDLIHTLPNFSNSEFQYTKSMAYEQISNTWLIVLNHKMRPDDGTNNNNTSNTNEALSSSSSPSPVAQCNMENSAQLIKIIDELNLQQKLAKHDNMSIGKFKLVVEFVNSEIENYENFNHTVTNNGGILNDLITVDYSNFSIAARTSH
What is the function of this protein?
Involved in ubiquitin-mediated protein degradation.  Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates.  Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
What are the official names of this protein?
Tethering factor for nuclear proteasome STS1.
What is the protein family that this protein belongs to?
Belongs to the cut8/STS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: NDRG3_HUMAN
Sequence: MDELQDVQLTEIKPLLNDKNGTRNFQDFDCQEHDIETTHGVVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQEGAPSFPTGYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLVLINVDPCAKGWIDWAASKLSGLTTNVVDIILAHHFGQEELQANLDLIQTYRMHIAQDINQDNLQLFLNSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVGDNSPAVEAVVECNSRLNPINTTLLKMADCGGLPQVVQPGKLTEAFKYFLQGMGYIPSASMTRLARSRTHSTSSSLGSGESPFSRSVTSNQSDGTQESCESPDVLDRHQTMEVSC
What are the official names of this protein?
Protein NDRG3, N-myc downstream-regulated gene 3 protein.
What is the protein family that this protein belongs to?
Belongs to the NDRG family.
Protein: FTMG_ASPFM
Sequence: METLDAIQLPYLGVVGASLIVILGIILLFPLGSDPFITINQHPRDLFQTKAKQQFEYNAAALLNEGLQTGHSAFRLVTNMVTYLILKDQYAEEIKNDSRFGAHEAVDPVLLVDLPGLESMFQGSLHNQVPPMAVRALNKELVHLTPSLSEEAMNCLQTRWTDSTEWHGVSIPETVLALIAQMTTRALLGPELCRNPEWLDIAKSFTTNRAIAVAAVQSWPSFLQPVIHWFLPPCRALRRQIQCARNIILPALERERRAYCSDQPTKREFSNLVFIDQYAKGARYDATMAQLRIIAVAFQTTSDLVEKVIARLCKHPELIEPLREEVVSVVGNRGLHRHSLRKLTLMESVMKETQRLEPAVIIGMFRLAKEKVTLKDGTVVPKGTNIAFANDLRFDPEMYLEPETFDGYRFQRMREDPAKIDLAPFTKTRMSHLAFGHGKHACPGRFLACDEAKLILCHILLNYDIRAVEGSPPELRARGMFVQLDPGAMMSVRRRRGTETAPHG
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumitremorgins, indole alkaloids that carry not only intriguing chemical structures, but also interesting biological and pharmacological activities (PubMed:19226505, PubMed:23649274).  The biosynthesis of fumitremorgin-type alkaloids begins by condensation of the two amino acids L-tryptophan and L-proline to brevianamide F, catalyzed by the non-ribosomal peptide synthetase ftmA (PubMed:16755625).  Brevianamide F is then prenylated by the prenyltransferase ftmPT1/ftmB in the presence of dimethylallyl diphosphate, resulting in the formation of tryprostatin B (PubMed:16000710, PubMed:21105662, PubMed:23090579).  The three cytochrome P450 monooxygenases, ftmP450-1/ftmC, ftmP450-2/ftmE and ftmP450-3/FtmG, are responsible for the conversion of tryprostatin B to 6-hydroxytryprostatin B, tryprostatin A to fumitremorgin C and fumitremorgin C to 12,13-dihydroxyfumitremorgin C, respectively (PubMed:19226505).  The putative methyltransferase ftmMT/ftmD is expected for the conversion of 6-hydroxytryprostatin B to tryprostatin A (Probable).  FtmPT2/FtmH catalyzes the prenylation of 12,13-dihydroxyfumitre-morgin C in the presence of dimethylallyl diphosphate, resulting in the formation of fumitremorgin B (PubMed:18683158).  Fumitremorgin B is further converted to verruculogen by ftmOx1/ftmF via the insertion of an endoperoxide bond between the two prenyl moieties (PubMed:19763315).  In some fungal species, verruculogen is further converted to fumitremorgin A, but the enzymes involved in this step have not been identified yet (Probable).
What are the official names of this protein?
Fumitremorgin C monooxygenase, Cytochrome P450 monooxygenase ftmP450-3, Fumitremorgin biosynthesis protein G.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL29_FRATW
Sequence: MKRKDTLKDYRGKSIDQLQEAKIELLQQLFSLRMQKGTGQLKKNHLFKSAKRDIARINTIISEKNK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: ICAM3_HUMAN
Sequence: MATMVPSVLWPRACWTLLVCCLLTPGVQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSHFVPVFVAVLLTLGVVTIVLALMYVFREHQRSGSYHVREESTYLPLTSMQPTEAMGEEPSRAE
What is the function of this protein?
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173).  ICAM3 is also a ligand for integrin alpha-D/beta-2.  In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
What are the official names of this protein?
Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. ICAM family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: PDXJ_EHRRW
Sequence: MSSIALGVNIDHIATLRNARNTEYPDLVEIANIAVNNGADFITVHLREDRRHIRDSDVFRLKDNLNVPLNLEIAAIDEMLAIAIAVQPECVCLVPEKRQELTTEGGLDVKNMFTYLMPFITQLHNHNIKVTLFVEPDINQINYAKKLSVDNIELHTGVYCNHNTQNELNRILEAAKHCYTNKIECHAGHGLDYQSAATIARVPYISALNIGHFLICEAVLHGIGTSIYKMKKVITNPL
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CALM2_PETHY
Sequence: MAEQLTEEQIAEFKEAFSLFDKDGDGCITTKELGTVMRSLGQNPTEAELQDMISEVDADQNGTIDFPEFLNLMARKMKDTDSEEELKEAFKVFDKDQNGYISAADVRHVMTNLGEKLTDEEVDEMIREADMDGDGQVNYEEFVRMMLAK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-2, CaM-2.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: ITP_EBVA8
Sequence: MASAMESDSGGGSGGADAQPPLAEVDGGLARVTRQLLLSGDDPAARLRALMPLELGIFGLGDLAQPVLVRDFLNTLTLMSGHAYPAAVLRHHAYYLLRAASFSRRSFGLGHLEAALDVLASSLPPTTASPATDDPLDGSRLIAETRALAATYRRIIEEGSGEVLAVSGPTATFAFVEELVADTYLARWDAFPREGLSFYAFNAAKTTLGRWLVTVYAETNRYPWAAAGQGQPTAADIKAMAVELVEHSGGGAGGGEGEESGGGGLFHRPESLSSVVASLPLARRRAVEILGVYAEASGGQTPPVAAVPVLAFDAARLRLLEPSGALFYDYVYEALLWDQTYGVPDSVIEAFLAGMAAEMEALAARVQEAAGSRASFSPAAIEQVATVLLSAGLNETVAGDYAMMLASVPRVSRSRWRWLEATAALLESLSGFALHFFRLLPTASPTSRFARVARAAYLRAEAEAVDRRARRTSGPSTPAAAPAATAVGVGAAADPWDAVTPLRIFIVPPPAAEYEQVAGDLSSELLRSLLWVRYSRLWQAPAPAPALPCKPPLLPGEQGRRQWTAAVAAAPRTDVEAYCRSLRAGQTARADPAYVRSPFFPAAFIEFQIWPALRRVLSNELPKTRSLAALRWLVSFGSDLALPSPELTRARRPLELIYATVWEIYDGAPPMPGESPQAVGLRPLNLEGEGKAGDAGAEGAEDEEGGGPWGLSSHDAVLRIMDAVREVSGIISETISASERAAEAPPLAWPTSLFSLLFTLRYSTTAESLGLATRRFLVSGETLSEDISRLTGAAWRLCSRPLLYDAETGRVQIPLATEEEEEAVVAVKEKSVSSSPRHYSTDLQTLKSVVEGIQDVCRDAAARWALATADTATLRRRLLVPALRESRGIADHPLWAHTSEPLRPDLEELNERVEHALELGYSLTGALRRSVAYRFRDYTFARLFQPPAIDAERAEAIVRRDARPPPVFTPAPRRLPQGGADTPPPLSMDDILYLGKSICKALVDVLDHHPAAPETTPIKTYTPAMDLNPEQITVTPRSPSVLAAFARTARVQTHHLVPALTDDSPSPVGQTPPPFRILPAKKLAAILLGNGRNASKRRASRDLSPPPHGRWRAVLDSSPFSFSSSDFSDQDEGEGGEADLRGVPGGGGEGAYEEDRERPSDIDTAARAQKVETSCPRRRSPRTTPSPSRRASGGGGPDRGEAEAHTYPPYLSAAAAASRVRPRTRRGATRRPPRPTAEDE
What is the function of this protein?
Plays an essential role in cytoplasmic secondary envelopment during viral egress.  Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs.  Modulates tegumentation and capsid accumulation at the viral assembly complex.
What are the official names of this protein?
Inner tegument protein.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae inner tegument protein family.
What are the subcellular locations of this protein?
Virion tegument. Host cytoplasm. Host nucleus. Host Golgi apparatus, host trans-Golgi network.
Protein: MURG_LACJO
Sequence: MRVIFSGGGTGGHIYPIMALIERLKERKLVTNDEILFVGTDRGLESKIVPAAGVPFKTLKIKGFDRKHPLKNFETIELFIKATKEAKQIIKNFKPDVVVGTGGYVSGAIVYEAAKMHVPTIIHESNSVVGLANKFLAHYVDKICYTFDDAAKQFSEKKKLVKTGNPRSQQVLGLNKENIDIAKKWDLNPNMPTVLIFGGSRGALAINQIVEKSLSELETKPYQVIWATGQLYYGDVKKKLAGKEVNSNIKIVPYIDNMPGLLPQMTCVVARSGATSLAEFTALGVPVILIPSPNVTHNHQMKNALDMEKAGAALVIAENDLNPNNFVSSIDHILLDTNYAKKMSEASKKLGVPDASDQVISVMESLIKNK
What is the function of this protein?
Cell wall formation.  Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
What are the official names of this protein?
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase, Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 28 family. MurG subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DAPE_WOLTR
Sequence: MKIDPVELTKKLISFKSITPRDDGAIEHIAAILEKSGFDCEILEFGDNKTKVKNLYAKYINGVQNLCFAGHVDVVPPGQLKDWISDPFSPEVRDGLLYGRGATDMKSGIAAFITAMVDLVAEKFRFNGSISALITSAEESTEEYGTKAVLKWMESKHKKIDYCVVAEPTSSEKLGDTIKIGRRGSATFELICHGKQGHVAYPDLADNPIYKMISILNRIKDTTFDGGNKYFQPSNCEITTIDVGNSTDNVILDSITAGFNIRYNNMQTPDGLYKLIDEICFSVTNDYKLSMHSSRGAFLSTPDRNTDVMFDAINKVTNIDAVLATSGGTSDAAFIKDVCPVIEFGMINKTSHQVNECVLVNDIHKLTAIYKEFIKSYFYPTNRILNQINVIGNVPDSPLLA
What is the function of this protein?
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
What are the official names of this protein?
Succinyl-diaminopimelate desuccinylase, SDAP desuccinylase, N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20A family. DapE subfamily.
Protein: CETZ3_HALVD
Sequence: MKLALIGIGQAGGKVVDALVDYERRTKTGFVVDAIAVNSARADLRGLRTAPESRQVLVGLTRVKGHGVGADNELGAEVIAEDVGEVLSMIDDLPVHEIDAFLVVAGLGGGTGSGGAPVIARELKHIYTEPVYGLGILPARDEGGIYTLNAARSFQTFVREVDNLIVFDNDAWRKTGESLEAGYGSLNAELARRLGVLFSAGEGDGSGAVAESVVDASEIINTLGSGGVSTIGYAAVELDRPKRGLLSRLSGGKAEADDGGDSTNRITSLVRRAALGRLTLPCEISGAERGLVVVAGPSDVLSRRGIERARTWLEDETGTMEIRGGDYPIDSNFVAAVVLLSGVYDVPRVKELQAVAIETQRDMLAKRESSAASLDDLVSTGDDRIEPLF
What is the function of this protein?
Involved in cell shape control.
What are the official names of this protein?
Tubulin-like protein CetZ3, Cell-structure-related euryarchaeota tubulin/FtsZ homolog 3.
What is the protein family that this protein belongs to?
Belongs to the CetZ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_BRUAB
Sequence: MAQLIDGKKLAEDVVSTVKTETEKLVAATGVVPGIAVVIVGEDPASQVYVASKSRKAKECGFHSVQHDLPETASEQELLNLIEGLNNDPAIHGILVQLPLPGHIDSGRVIQTIAPEKDVDGFHFINVGKLGTGEVETAFVPCTPAGAMIMIERVHGRDLSGLNAVVIGRSNIVGKPMFNLLLAANATVTVAHSRTKDLPAIARNADILVAAVGRPQMVKGDWVKPGATVIDVGINRIPAPERGEGKTRLVGDVDFAEAEKVAGAITPVPGGVGPMTIAMLMANTLTAACRSAGMKKPVF
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: Y120_LACLA
Sequence: MMNMQSMMKQAQKLQKQMQVSQEEIANTTFVGKSAQDLVTVEFSGDRTLKSLDIKPDVIDPEDPETLQDMVTDAVNDALSQIEKVTEQKLGKFTKGLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein LL0120.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: HYPB_RHILV
Sequence: MCTVCGCGTSAIEGHTHEVGDDGHGHHHHDGHHDHDHDHDHHRGDHEHDDHHHAEDGSVHYSKGIAGVHVPGMSQERIIQVEKDILSKNDAYAAENRRHFERQGVFALNFVSSPGSGKTSLLVRTIKDLKDRLSISVIEGDQQTSNDAARIRETGARAIQINTGKGCHLDAHMVGHAVEDLAPEPGSALFIENVGNLVCPAAFDLGEAHKVVVLSVTEGEDKPLKYPDMFAAADLMILNKADLLPHLDFNTGFCIANALRVNPRLQTLTVSARTGEGMEAFYAWLEVSAARRAIRSKVA
What is the function of this protein?
Involved in the maturation of [NiFe] hydrogenases.  Required for nickel insertion into the metal center of the hydrogenase.  Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion (By similarity).  Is able to bind 4 nickel ions per subunit.  Can also bind zinc (PubMed:7928968).
What are the official names of this protein?
Hydrogenase maturation factor HypB.
What is the protein family that this protein belongs to?
Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.
Protein: PNP_STRTD
Sequence: MAKQTFEMTFEGRPLVVEVGQVAKQANGAVVVRYGDTTVLSVAVMSKKMATADFFPLQVNYEEKMYAAGKFPGGFSKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSYDENASAPMAAMFGSSLALSISDIPFNGPIAGVQVAYAAEDFIINPSASDKEVSHLDLIVAGTKEAINMVEAGAQELSEDIMLQALLKGHEAIQELVDFQNYIVAAVGKEKAEVELFQVNADLKAEIEAVYYDQLAKAVQVEEKLAREAATKAVKEEVLASYQERFAEDEDKETILRDVVEILEQMEHAEVRRLITEDKVRPDGRRVDEIRPLDAEIDFLPKVHGSGLFTRGQTQALSVLTLAPMSDTQLVDGLDPEYKKRFLHHYNFPQYSVGKTGRYGAPGRREIGHGVLGERALAQVLPSVEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGTNYTVLTDIQGLEDHFGDMDFKVAGTRLGITALQMDIKISGITPAILEEALAQAKVARFEILDVIESAIAEPRSELAPTAPKIDSIQIPVDKIKVVIGKGGETIDKIIAETGVTIDIDEEGLVQIFSSDQDAIDRAKTIISDLVREAKVGEVYTVPVVRIEKFGAFVHLFNKTDALVHISELAWKHTEHVEDVVKVGDMVTVKIIKIDEKGRVDASIKTLLPKPEKNEDGENGEEHRHCCCSHHKPDHHSESMEAPKKSDESETKE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.