PharMolix/UniProtQA huggingface dataset:
Protein: APPX_ECOLI
Sequence: MWYLLWFVGILLMCSLSTLVLVWLDPRLKS
What is the function of this protein?
Might be part of cytochrome bd-II oxidase (appB and appC).  Able to restore reductant resistance to a cydX deletion mutant upon overexpression.  CydX and this protein may have some functional overlap.
What are the official names of this protein?
Putative cytochrome bd-II ubiquinol oxidase subunit AppX.
What is the protein family that this protein belongs to?
Belongs to the cytochrome ubiquinol oxidase subunit X family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein. Note=In sucrose cushions fractionates with the outer membrane, in sarcosyl fractionation with the inner membrane. May have its C-terminus in the cytoplasm (PubMed:21778229).
Protein: AROA_SHEAM
Sequence: MDQLRLEPVSRVNGVVNIPGSKSISNRALLLATLASGETTLVNLLDSDDIRHMLNALKSLGVNFTLSDDKTVCTLNGLGGPIQTDKAFELFLGNAGTAMRPLCAALTLGTGEFTLTGEPRMEERPIGDLVDALRQLGADIRYLKNDGFPPLTINATGLAGGVVEIDGSLSSQFLTALLMVAPLAKGAVTIAVKGELVSKPYIDITLDLMAKFGVTVVNDNYQRFEIASGQHYVSPGKVLVEGDASSASYFLAAGAIGGGEVKVTGVGRLAVQGDVKFADALAAMGADIEWGEDYIIARGSKLHGIDMDMNHIPDAAMTIATAALFAEGTTRMSNIYNWRIKETDRLAAMATELRKVGAKVEEGHDYIQITPPVKPVHAEIDTYNDHRMAMCFSLLAFADCGVTINDPGCTSKTFPDYFNRFANLAKPD
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_PSEA7
Sequence: MNQDQLKQAVAQAAVDHILPHLDSKSIVGVGTGSTANFFIDALARHKAEFDGAVASSEATAKRLKEHGIPVYELNTVSELEFYVDGADESNERLELIKGGGAALTREKIVAAVARTFICIADASKLVPILGQFPLPVEVIPMARSHVARQLVKLGGDPVYREGVLTDNGNIILDVHNLRIDSPVELEEKINAIVGVVTNGLFAARPADLLLLGTADGVQTLKA
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: MECA2_BACCR
Sequence: MRLERLNYNKIKIFLTFDDLSERGLTKEDLWRNAPKVQQLFRDMMQEANKELGFEADGPIAVEVFSLQAQGMVVIVTKENQEMDTDDEFRDEFIEMQVTLDESEHILYEFATLDDVINLSNRLYNLGVTGGKLYTWDERFYLWVEEEEQIQLLKADFIAILAEYGNPSTATIYRIMEYGKELMDVNAIEQIHNYFVKKQNLS
What is the function of this protein?
Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.  Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease.  When overexpressed, inhibits sporulation.  Also involved in Spx degradation by ClpC (By similarity).
What are the official names of this protein?
Adapter protein MecA 2.
What is the protein family that this protein belongs to?
Belongs to the MecA family.
Protein: ARPC5_RAT
Sequence: MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV
What is the function of this protein?
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF).  The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility.  In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA.  The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, p16-ARC.
What is the protein family that this protein belongs to?
Belongs to the ARPC5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cell projection. Nucleus.
Protein: APCD1_HUMAN
Sequence: MSWPRRLLLRYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFITRSYRFYHNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHNVQVICHTEAVAEKLGQQVNRTCPGFLADGGPWVQDVAYDLWREENGCECTKAVNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDIHTDATQRMFYRPSSYQPPLQNAKNHDHACIACRIIYRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVCKHPTFSIYARGRYSRGVLSSRVMGGTEFVFKVNHMKVTPMDAATASLLNVFNGNECGAEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDARGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASSSPRAEDLAEDSGSSLYGRAPGRHTWSLLLAALACLVPLLHWNIRR
What is the function of this protein?
Negative regulator of the Wnt signaling pathway.  Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin.  May act via its interaction with Wnt and LRP proteins.  May play a role in colorectal tumorigenesis.
What are the official names of this protein?
Protein APCDD1, Adenomatosis polyposis coli down-regulated 1 protein.
What is the protein family that this protein belongs to?
Belongs to the APCDD1 family.
Protein: LIPA_BARBK
Sequence: MVTVVDKVTSMRVRHPEKAHRPDTSIQKKPDWIRVKAPTSQVYKETHGIVRANKLVTVCEEAGCPNVGECWSQRHASFMILGEICTRACAFCNVATGIPLAVDDDEPERVADAVAQMGLKHVVITSVDRDDLADGGAQHFAKVIYAIRRKSLGTTIEVLTPDFRHKDHALEIVVAAKPDVFNHNLETVPSKYLKVRPGARYFHSIRLLQRVKEIDPMIFTKSGIMVGFGEERNEILQLMDDLRSADVDFMTIGQYLQPTRKHHPVIRFLPPDEFESFAKIGKAKGFLHMASSPLTRSSHHAGDDFEILKKARAQKFS
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_STRTD
Sequence: MTKLVVGLGNPGSKYHETRHNVGFMAIDLMAKELGLTFSEEKTFKAEVASTFLNGEKVYFVKPTTFMNLSGLAVRALLAYYNIPMEDFIVIYDDLDMEVGKLRFRQKGSAGGHNGIKSIIAETGTQEFDRIKIGIGRPQKGMTVVNHVLGKFSEDDYAMILLTLDKVETALHHYLKTNDFEDTMRRYNG
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSRR_SALCH
Sequence: MQLTSFTDYGLRALIYMASLPDGRMTSISEVTEVYGVSRNHMVKIINQLSRAGFVTAVRGKNGGIRLGKPANTICIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLKELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: GBP_MYTSE
Sequence: MKLTISILFCVILTLQYNGADGKLKDLFGKIHDSVHGTADKVKEDLNSLFHPNDKNQQGNNDASSNIHFADSEENTDAAKKPDEVTPATTTTTTAAPAVPNAPSDNPTTLAPSTTTKDGRENFSGGCVAGYMRTPDGRCKPTFYQ
What is the function of this protein?
Biogenic peptide that prevents the onset of metamorphosis from larva to pupa.  Has repressive activity against juvenile hormone esterase.  Induces cell proliferation at low concentrations and inhibits it at high concentrations.  Mediates the spreading of plasmatocytes to foreign surfaces.  May have a role in the regulation of dopamine concentrations.
What are the official names of this protein?
Growth-blocking peptide, long form, GBP.
What is the protein family that this protein belongs to?
Belongs to the GBP/PSP1/paralytic peptide family.
Protein: DEGM_BACB2
Sequence: MSGAVLLCLFFSINVGNIQWDLRYIPILLAFLYGGKRAGWGVAAIAVVGRIGQGGDLFLLGVVLIVLTALFYALCVNRFYMLPPRWSRIRYASLLVILPATIQTFGTLYLINYENHLSESWVAGWLYIVFLVVTVVLVTYLFETLLEKERIVAELVATEKDFTKGELAASIAHEVRNPLTVVKGFVQLLSEDKQHAEYHKLILSELDRAESIIYEFLNTTRPQTNATFHLNETAREVVALLTPYAQERSIQLTIGTCEQAIVNGNENKVKQALMNFVKNGIEASNEGDTVTIQLDRLKDRAQIEINDNGVGMSRQQLKQLGTAYFTTKESGNGIGTMVSIRIVEMMNGMVTFKSKPGKGTKVVLSLPIEKENE
What is the function of this protein?
Involved in a sensory transduction pathway that enhances the production of minor proteases.
What are the official names of this protein?
Sensor protein DegM.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NAGB_BACTN
Sequence: MRLIIQPDYQSVSQWAAHYVAAKIKAANPTPEKPFVLGCPTGSSPLGMYKALIDLNKKGIVSFQNVVTFNMDEYVGLPKEHPESYYSFMWNNFFSHIDIKKENTNILNGNAPDLDAECARYEEKIKSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRQKTLTTDTIIANSRFFDNDINKVPKTALTVGVGTVLSAKEVMIIVNGHNKARALYHAVEGSITQMWTISALQMHEKGIIVCDDAATEELKVGTYRYFKDIEAGHLDPESLIK
What is the function of this protein?
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
What are the official names of this protein?
Glucosamine-6-phosphate deaminase, GlcN6P deaminase, GNPDA, Glucosamine-6-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
Protein: RS8_CLOPS
Sequence: MVMTDPIADLLTRVRNANSVRHEVVEVPSSSVKKAIVNILLQEGYLKGVEEYNDGVVPMMRLTLKYGANNERVITGLKRISKPGLRVYCKKDEVPRVLNGLGIALISTSKGLVVDREARKLGLGGEVICYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: CYC_SHEEP
Sequence: MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFSYTDANKNKGITWGEETLMEYLENPKKYIPGTKMIFAGIKKKGEREDLIAYLKKATNE
What is the function of this protein?
Plays a role in apoptosis.  Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol.  Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: TM135_XENLA
Sequence: MAALSKSIPHSCYEIGHTWNPSCFGSYLQITQGAMEESFKIYAPLYLVAAILRRKNLDYYVHKLLPELLQSTSFLTANGSLYIAFFCILRKLLGRFYFWTPGFGAALPASYAAILIERKSRRGLLTIYMANQATEALFRMGVTRGYIKPIRHGEVLLFCITSALYMFFFRCRDGLKGFAFSALKFIVGKEEIPAHALLPENMYVKAEQKSKEHRGLSRNSLKRLMDIICKHGPRHRCCKHYEDNCISYCIKGFIRMFSIGYLIQCCLRIPSTFRHLFTKPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHALVAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKCPYFPHADSVIYAVSTAVCFHAAVMEVQNLRPSYWKFLQRLTKGRFALMNRKALDVFDSEASKNFNNFVPKLDPRFCIVKPELPLDFS
What is the function of this protein?
Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission.  May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L.  May be involved in peroxisome organization.
What are the official names of this protein?
Transmembrane protein 135, Peroxisomal membrane protein 52, PMP52.
What is the protein family that this protein belongs to?
Belongs to the TMEM135 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.
Protein: EX7S_VIBA3
Sequence: MATKKPENMSFEAAIEELDGLVDQLENGDLALDDALKKFERGISLARAGQSKLNDAEQRVSILLKNDENAELSDFNPQPE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLUC_BOVIN
Sequence: MKSLYFVAGLFVMLVQGSWQRSLQNTEEKSSSFPAPQTDPLGDPDQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVNIVEELRRRHADGSFSDEMNTVLDSLATRDFINWLLQTKITDRK
What is the function of this protein?
May modulate gastric acid secretion and the gastro-pyloro-duodenal activity.  May play an important role in intestinal mucosal growth in the early period of life.
What are the official names of this protein?
Pro-glucagon.
What is the protein family that this protein belongs to?
Belongs to the glucagon family.
What are the subcellular locations of this protein?
Secreted. SUBCELLULAR LOCATION: [Glucagon-like peptide 1]: Secreted.
Protein: MAP2_SACS2
Sequence: MTEDELNKLLLAGKIAAKARDEVSLDVKASAKVLDICEEVESIIIENKAFPSFPCNISINSEAAHYSPTINDEKRIPEGAVVKLDLGAHIDGFISDTAITISLDSRYQRLLDASKTALEAAITNFKAGLSIGEIGRVIEKVIRAQGYKPIRNLGGHLIRRYELHAGVFIPNVYERGLGVIQSDSVYAIEPFATDGGGEVVEGKSITIYSLKNPNIKGLSSRENELIDFIYTRFNYLPFSERWLKEFSTNVDELRNNIKNLVKKGALRGYPILIEIKKGVVSQFEHTVIVKGDSIIVSTKSL
What is the function of this protein?
Removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase, MAP, MetAP, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
Protein: P29_MYCPN
Sequence: MVNPVLVFDQVSLRYNGAPLLENINFTISPGEHICLLGKSGVGKTSLLNCITNTKTISKGTIYFNGIASNNKDYKQLKKQFSFLDQVPNLIDTDFVYDAIWREAKNNLKWWQRLFLVEPQSLREQIIQILEEVNLKEYVTYIIKDLSGGQKQRVEVAKLFFANSQVLLVDEPTTGLDLINAHKIMELIIQFARQKAMTLIFVTHDVEFALKYSDRIIALKNKALVLDQATNKLTKQKLMQIYHD
What is the function of this protein?
Part of a high-affinity transport system.
What are the official names of this protein?
Probable ABC transporter ATP-binding protein p29.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: RBFA_PELTS
Sequence: MSFRSERVAEAIKKEVSDMLRNELKDPRIGFVTITSVEVSKDLRYANIYASVFGSPDDQKETIEALKKAQGFIRGELGKRIRLRYTPEITFKLDQSIGRGSRVLALMEEVREKGGGQDE
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYSJ_ECOL6
Sequence: MTTQVPPSALLPLNPEQLARLQAATTDLTPTQLAWVSGYFWGVLNQQPAALAATPAPAAEMPGITIISASQTGNARRVAEALRDDLLAAKLNVKLVNAGDYKFKQIASEKLLIVVTSTQGEGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDSSYEFFCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDALKSRAPVAAPSQSVATGAVNEIHTSPYSKDAPLAASLSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVEGKTLPLNEALQWHFELTVNTANIVENYATLTRSETLLPLVGDKAKLQHYAATTPIVDMVRFSPAQLDAEALINLLRPLTPRLYSIASSQAEVENEVHVTVGVVRYDVEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPTNPETPVIMIGPGTGIAPFRAFMQQRAADEAPGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLTRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDANRMAKDVEQALLEVIAEFGGMDTEAADEFLSELRVERRYQRDVY
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.  The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
What are the official names of this protein?
Sulfite reductase [NADPH] flavoprotein alpha-component, SiR-FP.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Protein: GP101_MOUSE
Sequence: MPPSCTNSTQENNGSRVCLPLSKMPISVAHGIIRSVVLLVILGVAFLGNVVLGYVLHRKPNLLQVTNRFIFNLLVTDLLQVALVAPWVVSTAIPFFWPLNIHFCTALVSLTHLFAFASVNTIVVVSVDRYLTIIHPLSYPSKMTNRRSYILLYGTWIAAFLQSTPPLYGWGHATFDDRNAFCSMIWGASPAYTVVSVVSFLVIPLGVMIACYSVVFGAARRQQALLYKAKSHRLEVRVEDSVVHENEEGAKKRDEFQDKNEFQGQDGGGQAEAKGSSSMEESPMVAEGSSQKTGKGSLDFSAGIMEGKDSDEVSNGSMEGLEVITEFQASSAKADTGRIDANQCNIDVGEDDVEFGMDEIHFNDDVEAMRIPESSPPSRRNSTSDPPLPPCYECKAARVIFVIISTYVLSLGPYCFLAVLAVWVDIDTRVPQWVITIIIWLFFLQCCIHPYVYGYMHKSIKKEIQEVLKKLICKKSPPVEDSHPDLHETEAGTEGGIEGKAVPSHDSATSP
What is the function of this protein?
Orphan receptor.
What are the official names of this protein?
Probable G-protein coupled receptor 101.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YPHA_SHIFL
Sequence: MNTLRYFDFGAARPVLLLIARIAVVLIFIIFGFPKMMGFDGTVQYMASLGAPMPMLAAIIAVVMEVPAAILIVLGFFTRPLAVLFIFYTLGTAVIGHHYWDMTGDAVGPNMINFWKNVSIAGAFLLLAITGPGAISLDRR
What are the official names of this protein?
Inner membrane protein YphA.
What is the protein family that this protein belongs to?
Belongs to the DoxX family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCX47_MESMA
Sequence: MNYLIVISFALLLMTGVQSGRDAYIADSENCTYTCALNPYCNDLCTKNGAKSGYCQWAGRYGNACWCIDLPDKVPIRISGSCRGR
What is the function of this protein?
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.  This toxin expressed with the pET-14b vector has low inhibitory activity on sodium channels (11. 33% on rNav1. 2/SCN2A, 15. 96% on mNav1. 4/SCN4A and 5. 04% on hNav1. 5/SCN5A).  When expressed with the pET-28a vector, this toxin has higher inhibitory activities (44. 12% on rNav1. 2/SCN2A, 25. 40% on mNav1. 4/SCN4A and 65. 34% on hNav1. 5/SCN5A).
What are the official names of this protein?
Alpha-toxin BmalphaTx47.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: EAA3_HUMAN
Sequence: MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
What is the function of this protein?
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949, PubMed:33658209).  Can also transport L-cysteine (PubMed:21123949).  Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:33658209).  Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923).  Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949).  Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).  Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity).  Negatively regulated by ARL6IP5 (By similarity).
What are the official names of this protein?
Excitatory amino acid transporter 3, Excitatory amino-acid carrier 1, Neuronal and epithelial glutamate transporter, Sodium-dependent glutamate/aspartate transporter 3, Solute carrier family 1 member 1.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily.
Protein: PYLB_METAC
Sequence: MIKKMATEDLDRFGEKIIEGFQLSDDDLRALLSLESEEELEKLYYVARKVRNHYFGNRVFLNCFIYFSTYCKNQCAFCYYNCKNEINRYRLSREEIKETCKALKGAGFHMIDLTMGEDPYYYEEPDRFVELVQMVKNELGLPIMISPGVMDNATLLKAREKGANFFALYQETYDQELYEKLRVGQSFKGRYNTRRFAKEQGYCIEDGILTGVGNDIESTIKSLRGMKSNDPDMVRVMTFLPQEGTPLERFKENSNLSELKIIAILRLIFPKCLIPASLDLEGIDGMVHRLNAGANIVTSILPSDSKLEGVANYDRDLEERDRDIKSVIKRLEGMGMEPAPQAEFETVLRC
What is the function of this protein?
Catalyzes the isomerization of L-lysine to (2R,3R)-3-methylornithine via a radical-based mechanism (Probable).  Is required for the biosynthesis of pyrrolysine.
What are the official names of this protein?
3-methylornithine synthase, (2R,3R)-3-methylornithine synthase, (3R)-3-methyl-D-ornithine synthase, Pyrrolysine biosynthesis protein PylB.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. PylB family.
Protein: LBR_HUMAN
Sequence: MPSRKFADGEVVRGRWPGSSLYYEVEILSHDSTSQLYTVKYKDGTELELKENDIKPLTSFRQRKGGSTSSSPSRRRGSRSRSRSRSPGRPPKSARRSASASHQADIKEARREVEVKLTPLILKPFGNSISRYNGEPEHIERNDAPHKNTQEKFSLSQESSYIATQYSLRPRREEVKLKEIDSKEEKYVAKELAVRTFEVTPIRAKDLEFGGVPGVFLIMFGLPVFLFLLLLMCKQKDPSLLNFPPPLPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY
What is the function of this protein?
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis (PubMed:9630650, PubMed:12618959, PubMed:16784888, PubMed:21327084, PubMed:27336722).  Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation (By similarity).  Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation (By similarity).  Anchors the lamina and the heterochromatin to the inner nuclear membrane (PubMed:10828963).
What are the official names of this protein?
Delta(14)-sterol reductase LBR, Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, C14SR, Integral nuclear envelope inner membrane protein, LMN2R, Lamin-B receptor, Sterol C14-reductase.
What is the protein family that this protein belongs to?
Belongs to the ERG4/ERG24 family.
What are the subcellular locations of this protein?
Nucleus inner membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Cytoplasm. Nucleus. Note=Nucleus; nuclear rim.