PharMolix/UniProtQA huggingface dataset:
Protein: Y8359_DICDI
Sequence: MNINRNNINDSNRHSTSFNDNFDSFGNQNGFINNNSNNNNNNKNNNNNKNNNNNNNNNDYNNNNNRSSNNGDNCNNNNINKNNYNNNYNNNNSFDNNNFNNNNNKGFNDSNNNNHTNNNINPKNNFDRSSNKGFGPLNDNFILSPIKNIFRGDFCNESIVLKPIKENIKINNNNNNNKDNNNSNFNNNNTNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNNNYDYNNNTNFNNNNTNNNNNYNNYNNNNNNNNNTNFNNNTNNTNNKNKNNSNNTTNNTNNYNKNNNNNNNNNKNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNINNKNNNNLNNYDNYRCNYQNSRIPNSACSTPLSSISPTQQETFLKFNESGGGLNNNTNFNNQTFGNNNKNQNNDNNLNNNDNDKNNYYDNQYNSNIDNIGNSDDSIGGQTNKNKNKNKNKNNNNNNNNNNNNNNNNNNNNNSNNDQKTSSSLDTMIDENWDQHKEKHNKKHENGDISESKPKKKIKSKYDLNIENSLKILTNFNNLNEKVEDVIQMDPVEKEFQNDLRIYSIVREISVSELETKSNNELIDISRILGLPVHKNHRSEIFFKLFNYLNFFKKKMEKKIEQRGLELKDILINSRPSEYNDYSFQNQKKQKTEQREHKDILANRIQNQIQEQVQNQIQFLIQNYNQNQNQNQKQNQNQNQKNQNHQPQPPLQPQRQRYFPQDKPQNQNNQPPLQHQHQYQYQYQNQDQYQDHDHEHEHDHDQNQNQNQNQHQSRNQNQDQYQDHDHEHEHDHDQNQNQNQYQSQNQQNQNQNQNQNLIQIQNHNRDIANYSLSNRDSNSRNEDNSCDFNYNSSCNNININNNNNNNNNNNNNNNNYYNYNQNQNQNQSQNHNRGILDNRINSNNSLSSRDSNGRNRDNSCDFNNYKKSSNNSNSNNNNNINNNNNNNNNNNNNNNNNNNKNNNNNNNNKNNNSNNNSYTCNNNSNNSFNNLSSIDRGYNNHNTNPNNPNNNPNNPNNNPNNPNNPNNPNNNTSNTSNTSNTNNTNNTNNTNTSNYNSNNSNSNNSNSDNINSNNINTNINTNINSNTNSNSNTNNINNINSNNINNINNINSNNNNNNPNPNTNSNNINTASNDSNSNNINTNSNNINPNINSDSNNNFNNNNNSNNNNINSNSNIFNNINSSIDRSNSNGFNNNNSNDQRNIDSSSNSDIVDVDSDDDSSGVFIVDDTSSNKSNRASSVKTLGTSSLAIKHEYDSRNKSSLNFFSDQTTLEDGNTSFDEKVLYIKRVLINDFRSKNHIVDMGKAIGIDVPPKDTKANVLTLMIAFVNDYLDQKKKRLESNSSWDPNGGNYIDHNEFFKTPTPGQRQVYNDDINDDNGNNNNNNSNNNINTNNNININTNINTNTNNNTNNNTNINTNANTNTNTYSNTNINNNTNTNSNGFNGNNIDNGSLNNNNFNNNSNNIDNGSLNNSNNIDNCSLNNNSNNNNNSNSNSNSNNNNNNNNYYNNNNNNNNNYNNYNGSYNCNNNNNSYYYNNNSSNNNNNSYNNNNNYYNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNRYDCNNNNNYSNNNSNSNSNNNSNYSNNSYDCNNDNNNNIFSNSNGHNDNDIGNDFDNDNDNDSYIDDDNNVYDNNDGDYNNNKNNNYNNNNNNNNNNNNSNNNNNNNNNNRSNYYGNEDNNINCIDTNGNGNGNIYSCSNSNSNSYSNSNSNSNSNSNSNSNNNSNNSNNSNNSNSNSNNNINNNNINNNNTNNNNNNNSYICNNNNNNNNNNNNKNNNNNNNNNNNNNNNNNSLYGKDNEGFSNQINDNFNFYKSQGNNILEDFNLNNFQTNDKILKEMIDKLNNYGISIKPKIGKGNSQMIVNEGERENKERLFWSVFRDKSLLDKIVSYLAECIQGKPKLTSFKYYNIVHIKWMLDNDYIELIQDKVFRNETLLFGAYKSEDMTKEEVVSILFKKVNQKNCKNSEEIEKQLKFYQLLVHRFGNEIFKGINGGIQGLLELAITAKNSIALIVLFSMIESNYTLTDEILLNSFKCTIKVNSFSMIKLITFKIIKKDYQIIRNYQEVTNTTFEQIFQSIINPSIKIINFLIDIGIVMFSFKRDDSPPICFDSILVKSNSNTLASEISTRKKNLRFVKEYKTIIGESGFINSNCGVISIEMDKHEPHPSRPSIFNKNSLKEIINACYLNINFNYDKNSPLLKRQIETLFLFYPVFYSTVEVISIITNRIEAVRNCFSKEQLSLKLKHLIKIYPEDSIQFKGINCLVSFYLSFDFQSKFYCLYLHYLIFGNFISNINSDVLNVLPKDFDLNYFEKSLKYGSSIYCAKFKNEIARNFPKLVKDKKFFILFKHCDKNSVASRYKKLEFFRTIINQQSHSTERCNFALFCLLISTNDLELIEAACNEFTVFKEGFSYDFRDKQSNLYKYCNQMYFKVKITIIDFIKTVEVSHFTLQNYLYLFKDFEKDFQVKHFKSSEVFIHYCQTFLSNYRGNNGQLVFIDTHVGDNMDLKSYNSFWNIVAFLIRNPLNINFKIIDPYTLFFNITLKISNINVDNNNNSAVMNSNQRDYEIFNNIFENIKYVITNYQPNGYIVYYKPSSLFGGDLYWCNKLIDWIFDNAKDDIINKRCKIEESDLIKCGKFNYLFYERGYYYFDSIRNRYLPFSGHPILDSGRLGNINLLHLFLNTSGLQIFEKEANREDRVRKQKGKKDKESSSSGSSIGNPSSSGGSDFYNLDDSENESDSENNNEIEDDMKSIYRFKEDFTSILMNASRYGRLNIFQYLYFNYPFLVSKRSWIAADNLVSKATRFGLLQNTTFQNIGKTAEDNGKSSYSLNFLINFILRFL
What are the official names of this protein?
Putative uncharacterized protein DDB_G0282133.
Protein: GLUP_BRUA2
Sequence: MATSIPTNNPLHTETSSQKNYGFALTSLTLLFFMWGFITCLNDILIPHLKNVFQLNYTQSMLIQFCFFGAYFIVSLPAGQLVKRISYKRGIVVGLIVAAIGCALFIPAASYRVYALFLGALFVLASGVTILQVAANPYVTILGKPETAASRLTLTQAFNSLGTTVAPVFGAVLILSAATDATVNAEADAVRFPYLLLALAFTVLAIIFAILKPPDVQEDEPALSDKKEGSAWQYRHLVLGAIGIFVYVGAEVSVGSFLVNFLSDPTVAGLSETDAAHHVAYFWGGAMVGRFIGSAAMRYIDDGKALAFNAFVAIILLFITVATTGHIAMWSVLAIGLFNSIMFPTIFSLALHGLGSHTSQGSGILCLAIVGGAIVPLIQGALADAIGIHLAFLMPIICYAYIAFYGLIGSKS
What is the function of this protein?
Intake of glucose and galactose.
What are the official names of this protein?
Glucose/galactose transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARP5L_RAT
Sequence: MARNTLSSRFRRVDIDEFDENKFVDEHEEAAAASGEPGPDPCEVDGLLRQGDMLRAFHAALRNSPINTKNQAVKERAQGIVLKVLTNFKSSEIEQAVQSLDRNGIDLLMKYIYKGFEKPTENSSAVLLQWHEKALAVGGLGSIIRVLTARKTV
What is the function of this protein?
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
What are the official names of this protein?
Actin-related protein 2/3 complex subunit 5-like protein, Arp2/3 complex 16 kDa subunit 2, ARC16-2.
What is the protein family that this protein belongs to?
Belongs to the ARPC5 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: PGK_DICT6
Sequence: MAKKTILDLQDEELKGKRVLVRVDFNVPIKNGVITDDRRIREALPTIKYLIDRGAKVILVSHLGRPKGFQDDLRLDPVAKRLSELLGKPVKKLNDCIGEEVEKEISNMKEGDVVLLENIRFYKEEEANDPEFAKKLAKLADLYVNDAFGTAHRAHASTAGVAQYIPGVAGLLMKKEIEIMGKALESPERPFICILGGAKVSDKIGVIKNLMTKVDGFLIGGGMMFTFLKALGYETGKSIVEDDKLELAKEIMNMAKERGVEFLLPKDAVVVKEIKEDAPTSIKDVDKFEKDDIGVDIGPKTIELFREEILKARTIIWNGPMGIFEIPAFANGTRRIAEAIAENKNCISIVGGGDSAAAIQMLGLEDKFTHISTGGGASLEFLEGKELPGVAVLQDK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS5_BACCR
Sequence: MIAIIDYGMGNIRSVEQALKYIGAEYIVTSDKKEILRSDGVILPGVGAFPKAMDVLEERDLVCVLKEVCDIGKPLLGICLGMQLLFERSEELKDCSGLGLLPGEIRKLKVSYKIPHMGWNELRKEREFPLWNGLVDGSFVYYVHSYYADCPDEIVCGVSDYGMQVPGFVAKGNVFGAQFHPEKSGEIGMQILKNFQGVVEAWKSSQLSI
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR.  The resulting ammonia molecule is channeled to the active site of HisF.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisH, IGP synthase glutaminase subunit, IGP synthase subunit HisH, ImGP synthase subunit HisH, IGPS subunit HisH.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GTRA_BPSFX
Sequence: MLKLFAKYTSIGVLNTLIHWVVFGVCIYAAHTNQAMANFAGFVVAVSFSFFANAKFTFKASTTTMRYMLYVGFMGTLSATVGWVADRCSLPPIVTLVTFSAISLVCGFVYSKFIVFRDAK
What is the function of this protein?
Involved in O antigen modification.  Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity).
What are the official names of this protein?
Bactoprenol-linked glucose translocase.
What is the protein family that this protein belongs to?
Belongs to the GtrA family.
What are the subcellular locations of this protein?
Host membrane; Multi-pass membrane protein.
Protein: LEU1_TRIV2
Sequence: MTTKPERIIIFDTTLRDGEQCPGATLNIDEKLAIAKQLARLGVDIIEAGFAFASPGDFEAVHKIAQTVGTENGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKKTRPEVIAIAEEMVAYAKSFTDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTINIPDTVGYTTPSEFGAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMAMHVRRQYFNPFLGRHPDSEEPLTNIDTKQIYKTSRLVSNLTGMLVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRTRLKELGFELSETELNKAFVKFKEVADKKKEISDWDLEAIVNDEIQQAPDLFRVELVQVSCGSNARPTATVTLRTPDGEELTDAAIGTGPVDAVYKAINRVVNVPNQLIEFSVQSVTAGIDAIGEVTIRLRYESRVFSGHAANTDIIVASAQAYVNALNRLYASLQTQDKQTEVTA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: RELL1_CHICK
Sequence: MAPPAASGIPSIAPSLGPTAVWLGNRSDLGDVQALASRDLPTTTVTAGNNNKPEHLEYVAFVLVPVFFIMGLLGILICHVLKKKGYRCTTEAEEVEEEEKPDEKIEMNETAHENSDTVGQIINYIMKNEANADVLKAMVADSSVFEPESPMSPNAPGSPTSPGSPLSPGAASLKHNCKGHHLHTVGGVIEKDVCSRCSHKRWHHIKPAHKSKEHRRSRLGEVTVLSVGRFRVTKVEHKSNSKERKSLMSVTGVEGLNGDMPATPVKQEAKEAPATPVKEGTQERRSSE
What are the official names of this protein?
RELT-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the RELT family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: TFB5_USTMA
Sequence: MKAYKGMLLTCDAAVKQLILSLDERNRFIIMDLDETHLLISPDRIDWLRAELEVELEKNTYTLEP
What is the function of this protein?
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.  In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment.  In transcription, TFIIH has an essential role in transcription initiation.  When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.  Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
What are the official names of this protein?
General transcription and DNA repair factor IIH subunit TFB5, TFIIH subunit TFB5, RNA polymerase II transcription factor B subunit 5.
What is the protein family that this protein belongs to?
Belongs to the TFB5 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RNH2_CHLPN
Sequence: MNTSISEIQRFLSMIAFEKELVSEDFSVVAGIDEAGRGPLAGPVVASACILPKGKVFPGVNDSKKLSPKQRAQVRDALMQDPEVCFGIGVISVERIDQVNILEATKEAMLQAISSLPISPDILLVDGLYLPHDIPCKKIIQGDAKSASIAAASILAKEHRDDLMLQLHRLYPEYGFDRHKGYGTSLHVEAIRRYGPSPCHRKSFSPIKQMCAIV
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DFA2_THEVB
Sequence: MLTETRPRDVQVAEIAPGVLVLRSRTWDRLKFEVEYGRQQGTTSNSYLIQAPQPALLDPPGESFTQIYLQELQRHIDLNQLRYLILSHVNSNRLATVKVLLEKAPQITLVCSKAGAVTLRSAIGEQLHLWIARADTPLELGGDRQLMFIAAATPRWPDGLITVDPQNQIVFSDKLFGAHVCGDSLYDEQWKKLDEDRAYYFECLHAAQTRQVESILDRLAELTPPPRLYAPAHGPIVKFSRSRLFQDYRDWCQAQAEQETKVALFYASAYGNTAILANAIAQGLTAAGVQVEAVNCETTPPAEMQALIHSSDGFIIGSPTLGGHMPTQVQTALGFILAEGSQTKLAGVFGSYGWSGEAIDDIEQKLLDAGYTLGFETLRVKFTPTATDLEKCQIAANEFAQALKKLRKSRTVRPSSLAEAQVDRTEQAVNRVVGSLCVLTTLPEGCFHLTQAAAILVSSVSQASFNPPGITVSLPQEWAESLCLVGDRFVLNILKEGSPLVRQFQQAQRLGEQQLATLGLKSAESGAPILLDALAYLECTVESRMNCGNHWLIYAVVESGELLQTSGLTAIQHRKTSS
What is the function of this protein?
Mediates electron transfer from NADH to oxygen, reducing it to water.  This modular protein has 3 redox cofactors, in other organisms the same activity requires 2 or 3 proteins (By similarity).
What are the official names of this protein?
Putative diflavin flavoprotein A 2.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the flavodoxin reductase family.
Protein: DNLI4_SCHPO
Sequence: MDEAKETVFTKPQNHSSTLEFYDFVTTLLEPLSRIGKTRKSKTSNLDPYELKRKILLDYFNKWRQHVGPDLYPLLRLMLPDLDRERGSYGFKEFGLGKLFIRAMHLSPTSEDAKSLKNWRGSESKHTGDFSTMLQDILQRRAYRTFPGAFTVGDVNALLDQLADASSEDTRVNILEQFYRSLSPLELRWLIPILLKVRKYGTSEKFILSVFHPDAARLYRLCSSLKRICWELYDPSRSLDETETDVEVFSCFQPQLANFKKKDLHQTLEAMGNKPFWIEEKLDGERIQLHMSSGKFQFYSRNARSYTYAYGSSYFDEQSRLTQYIIGAFDKRISQIILDGEMVTWDPVLETVIPYGSLRSIFEDSSSHSSYSPYYVVFDILYLNGKSLVKYSLESRRRILEKVIVRESHRMSILPYKVGSTIEDIEAELRNVIQEGSEGLVIKKPSGSYHLGERMDDWIKVKPYYLQGFGEDLDCLILGGYFGRGKQSGKINSFLCGLRMDYTPKDHSEKFQSFVRVGGGFTYFDRDIIRKETEGKWLPWSSDALEYMELAGTKQDFEKPDMWIHPKDSLVLQIKAAEVVVSNRFKTNYTLRFPRLEKVRLDRSWKDALTINEFFTLKNAVEKQDNVSFHVNKKRKVSQKREKQKKFLYDEPTFKKEASPHSDVLKNLHFVVLPPTELHETKAGLQQIIIENGGLIHQGVGNFGKERLFLVADRVSTRVSIERSKNMCTIIRSQWVMDSVNNQRLMPQWSYLLFSKDEKYSWKTALESLSAKSLSNLLVELKQLDLSKEYSKISDDTSILNLTISKEEASFVGAFPFLKFTVFLDLKGIENSELYDVRMGQYRLTKCILLWNGATIEKDISSKKLTHVVMFVEDSTRLEQLTKACELYQIEPKFVNFEWVVNEWKKASTNILG
What is the function of this protein?
Involved in ds DNA break repair.
What are the official names of this protein?
DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y777_STRP3
Sequence: MYSIKCDDNKVMPRERLMRLGAESLSNQELLAILLRTGNKEKHVLELSSYLLSHLDSLADFKKMSLQELQHLAGIGKVKAIEIKAMIELVSRILATDKTLTDSVLTSVQVAEKIMAALGDKKQEHLVVLYLDNQNRIFEEKTIFIGTVRRSLAEPREILYYACKNMATSLIVIHNHPSGNIEPSSNDYCFTEKIKRSCEDLGIICLDHIIVSYKDYYSFREKSTLF
What are the official names of this protein?
UPF0758 protein SpyM3_0777.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: RUTR_ECO57
Sequence: MTQGAVKTTGKRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFREDFAPLAAIKEYIRLKLEVSRDYPQASRLFCMEMLAGAPLLMDELTGDLKSLIDEKSALIAGWVKSGKLAPIDPQHLIFMIWASTQHYADFAPQVEAVTGATLRDEVFFNQTVENVQRIIIEGIRPR
What is the function of this protein?
Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines.  It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX) (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator RutR, Rut operon repressor.
Protein: HSLU_MAGMM
Sequence: MSEFTPREIVSELDRYIIGQNMAKRAVAIALRNRWRRQRLSAEMREEVYPKNILMIGPTGVGKTEIARRLAKLARAPFIKVEATKFTEVGYVGRDVESIVRDLVEMGITMVTEEAKVKVQFQAEDQAEERLLDILLPLPSTGQGEGSAHFGLFGQMEGSSVKPEPTAQQKESRQKMRKMLREGKLDDREIDIDLKEQRRVPMMEVITPQGMEGINLQDMLGGLMGGRTKTRRVKVGEAMKLLTEEEAGKLVDQDTVQQVAIERVEQSGIVFLDELDKVCARGSETRGGDVSREGVQRDLLPLVEGTTVSTKYGMVKSDHILFIASGAFQLAKPSDLLPELQGRLPIRVELESLGKGEFVRILTEPENALTRQYAALMGVENIELVFTDEGIEALAEIATRVNETAENIGARRLHTVMEKLLDELSFSAPDRGGERVVIDAAYVNRQLSDLAADEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUVB_PROM3
Sequence: MAIVSSSAGRADSQPPAAKSRVVDASPLPEEASPAREDGLRPKRLEDYIGQRELKQVLGIAVKAAMGRGDALDHVLLYGPPGLGKTTMAMVLAEELGVKCRVTSAPALERPRDIVGLLVNLQPREVLFIDEIHRLTRVAEELLYPAMEDRRLDLTVGKGSTARTRALELPPFTLVGATTRAGALSSPLRDRFGLIQRLEFYGLEDLQAIVERAAGLLRLQLTAQACQEIARRCRGTPRIANRLLRRVRDVASVCGGESLIDAALVDEALTLHRVDARGLDASDRRLLDLLLESHGGGPVGLETLAAALGEDPATLEAVVEPFLLQLGFLQRTPRGRVVTGAGRRHLGWPELP
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: FER_SCOJA
Sequence: ATYKVKLVTPDGPVEFDCPDDVYILDQAEEEGHELPYSCRAGSCSSCAGKVSAGTVDQSDGNFLDDDQMADGFVLTCVAYPQSDVIIETHKEEELTG
What is the function of this protein?
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
What are the official names of this protein?
Ferredoxin.
What is the protein family that this protein belongs to?
Belongs to the 2Fe2S plant-type ferredoxin family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: ACBP_SCHPO
Sequence: MSSTFEQAAADVKELKETPNSDELLKLYALFKQATVGDNNTEKPGLLDLKGKFKWNAWEELKGKSKEDAASEYISFVDELKTKYGMK
What is the function of this protein?
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.
What are the official names of this protein?
Putative acyl-CoA-binding protein, ACBP.
What is the protein family that this protein belongs to?
Belongs to the ACBP family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RAD14_SCHPO
Sequence: MENSSIVKSPNPTIEEQRNEIEKLKNLTGIEEVHVDGAKVNKRKRTFDEQSEITKDYIEYDFSKIEDTKGGYLLEEKKVEDLREKPAERELREQEERQKKLRLAPLNLDPETAPKCFECDSIELDTKYFDIFHCRVCHTCREKYPDKYSLLTKTECKLDYLLTEPELQDQELLPRLLKANPHQQGWSNMMLYLRYQVEEFAKKKWGSMEALDAEFERREVQKKEMKEKKFEKQLLELRKRTRTSNYSRMSIREKRKHVHSYDEEFEKPNEPGVIVQRCKCGLEIEQLEI
What is the function of this protein?
Involved in nucleotide excision repair (NER).  Functional in repair of ultraviolet radiation induced damages and in mitotic mutation avoidance.  Binds damaged DNA.  Binds specifically to base-base mismatches or small insertion/deletion loops with unpaired nucleotides.  Maintains GT repeat stability.  Functions as a part of the short-patch excision repair system.
What are the official names of this protein?
DNA repair protein rad14, XP-A family homolog rhp14.
What is the protein family that this protein belongs to?
Belongs to the XPA family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATC4_SCHPO
Sequence: MGSKALITSPDISSGQLYIKLPTFFHLYVWPFALFVYPYIGYVYQNKLYSEEVRYLTYIAVGTIHALFWLAGEWNTKVYCLMTCRKTDKVEQATHILVTPSKIGESSSVEPITKLVLPDSQTIQYSFSFQRKRFIYEPEKGCFANITFPMDEPSTIGTLKKSTGLTNIQSEIFLYRYGKNCFDIPIPTFGTLFKEHAVAPFFVFQIFCCVLWCLDDYWYFSLFSMFMIIALECSVVWQRQRTLTEFRTMSIKPYEIQVYRNKHWFPISTEDLLPNDVVSVLHNKEDSGLPCDLLLLSGSCVVNEAMLSGESTPLVKESIELRPEEAVIDVDELDKNAVLFGGTRVLQVTQSPFCKLKTPDNGVPAIVLRTGFETSQGSLVRTMVFSSEKVTANNRESLYFILFLLVFAIAASGYVWHVGSKTERSRYKLMLDCVMIITSVVPSELPMELSMAVNASLGALSKYYIYCTEPFRIPLSGHLDICCFDKTGTLTEEHMVVQGIAGVNRKDPYSLEKLSDASNDAILAIATAHTLVLLEQEGETPKVVGDPMEKATVENLGWSIEKKNFVSAPEGSVFYKGKVQIIRNFQFSSALKRQSSVSNVRVSGGSFKTFVSVKGAPEVIATMLREVPKDYEKIYKDYGRKGSRVLALGYKYFKNYIPENQVSDLSRESIESDLVFAGFLIFTSPLKEDARQTVQMLNNSSHRCMMITGDNPLTAVYVAEQVGIVEKPTLVLDIKHENEKILEWKSTDDTINLPMNPHKSLEASLYEKYDLCITGRALSQIINPDVIMSIFTHAWVYARVSPSQKEFMISTLKHNGYITLMCGDGTNDVGALKQAHVGVALLNASEEDMLEMQERARNQKLMGVYEKQIQLAKRFNLPTPPVPPALCHAFPPGPNNPHREKTQEGLNKVLEDLETKKASDVQLTEAEKAAERRANLANKMFDTLANASDDEAPKLKLGDASVAAPFTSKLAVVSSITNIVRQGRCTLVALVQMHKILALNCLITAYSLSVLHLDGIKFGDTQYTISGMLMSVCFYCVSRARPLETLSKERPQAGIFNTYIIGSVLGQFAIHIVTLIYITRVVYLYEDPLEKVDLEETFKPSLLNTAIYLLQLIQQVSTFAINYQGRPFREALSENKGMYYGLLGIAFVAIAGVTEFSPELNAKLQLVKMAYNFQIQLLATMVVDYAACWIIEELMKKYFRDNKPKEIVLRN
What is the function of this protein?
Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum.  Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane.  Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (By similarity).  Involved in controlling nuclear calcium ion levels.  Required for cytokinesis and stabilizing microtubules (PubMed:12058018).  Required for assembly of the forespore membrane (PubMed:16394583).  Involved in calcium transport to the endoplasmic reticulum (PubMed:22132152).
What are the official names of this protein?
Endoplasmic reticulum transmembrane helix translocase, P-type ATPase cta4, P5A-type ATPase cta4, Sporulation protein essential for vegetative growth 4.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: THIO_HORSE
Sequence: MVKQIESKSAFQEALNSAGEKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVVFLEVDVDDCQDVAAECEVKCMPTFQFFKKGQKVDEFSGANKEKLEATIKGLI
What is the function of this protein?
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity).  Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide.  Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity.  Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity).
What are the official names of this protein?
Thioredoxin, Trx.
What is the protein family that this protein belongs to?
Belongs to the thioredoxin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Secreted. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA). Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus. Secreted by a leaderless secretory pathway.
Protein: K2C6A_HUMAN
Sequence: MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAISGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSSGYGGASGVGSGLGLGGGSSYSYGSGLGVGGGFSSSSGRAIGGGLSSVGGGSSTIKYTTTSSSSRKSYKH
What is the function of this protein?
Epidermis-specific type I keratin involved in wound healing.  Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration.  Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
What are the official names of this protein?
Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Cytokeratin-6D, CK-6D, Keratin-6A, K6A, Type-II keratin Kb6.
What is the protein family that this protein belongs to?
Belongs to the intermediate filament family.