PharMolix/UniProtQA huggingface dataset:
Protein: GLMU_SORC5
Sequence: MATQPTPLTAVVLAAGQGTRMKSARPKVLHELCGRPMLHYVVDAALAAGASDVVVVVGHGRDEVSAALDKAFGAQGKKVRTALQPQQRGTGDAVRCAMPHIDATSEAILILCGDTPLLDPEQLTQLRGALDRAGDAPIAMLTAEVSDPTGYGRILRDASGRVIGIREHKDATAEERAITEVNPGVYLARSGFLGRALAGLTTDNAQGELYLTDIVAQAAKAGGAAAVVARDVGSLVGINDRAQLAAAEEVLYGRIADRLRKSGVTIRTSARIDAGVLVEPDAVIEHAVVLRGRTRVGAGARIDVGSVLTDVVVEAGASVKPYTVASQSSIGAGAQIGPFSHLRPESQIEADAHIGNFVETKKTVVRKGAKANHLAYLGDGDIGEGANVGAGTIFCNYDGFRKHRTEIGAGAFIGSDSQIVAPVKIGAGAYVATGTTVTRDVPDEALAIGRVKQENKEGYATRLKARLKDAAKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MURC_CAMJD
Sequence: MQNIHFIGIGGIGISALARFLKEKGFKISGSDLKESKITKELEKEGVKVSIPHHKDNILNKDLVIYSAAIKEENPEFKYAKELGIKCLSRKEALPLILEDKRVFAVAGAHGKSTTSSILASLLDDASVIIGAILKEFGSNMIYKESQNLIFEADESDSSFLNSNPYLAIVTNAEAEHLDHYGNEVSKLHHAYAEFLDTAKIRVINAEDEFLKNYKNESIKLYPSKDIKNCTMCIENFKPFTSFELKDLGEFKIFGMGYHLALDASLAILAALNFLDIETIGARLKNYQGIKKRFDILHADENLVLIDDYGHHPTEIKATLSAAQEYAKLGGYKKITAIFEPHRYTRLAVNLKEFAKAFEGVDELVILPVYAAGEEPIEIDLKAVFPKALFVENIQREGKFLVASKGQVFEEGLIIGFGAGDISNKLRQKNE
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_DESPS
Sequence: MAVTKEDVIDFIAGMSVLELSELIGEFEEKFGVSAAAPVAVAAAGVAAEAVEEKTEFDVILASAGSEKIKVIKEVRAITGLGLKEAKSLVESAPAALKEGVSKDEAAELKAKLEAVGATAEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: CH602_MYCVP
Sequence: MSKIIAYDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEKAVEKVTETLLKSAKEVETKEQIAATAAISAGDTQIGELIAEAMDKVGNEGVITVEESNTFGLQLELTEGMRFDKGYISGYFVTDAERQEAVLEDPYILLVSSKVSTVKDLLPLLEKVIQAGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAMLQDIAILTGGQVVSEEVGLSLETADVALLGTARKVVVTKDETTIVEGAGDSDAIAGRVAQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQSAPSLDELNLTGDEATGANIVRVALSAPLKQIAFNGGLEPGVVAEKVTNLPAGHGLNAATGEYEDLLKAGVADPVKVTRSALQNAASIAALFLTTEAVVADKPEKAAAPAGDPTGGMGGMDF
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Secreted, capsule. Cell surface. Secreted, cell wall.
Protein: Y756_METJA
Sequence: MKKLLMVILGIALIGMAYAFPPWMAYQTQTTENTDINPVDILKTAEVVQHTTPFGYNLSHLEIDGKIVGVLWKDVDLSKLEVGEPFNTPFGEKYPLYYDRELVGFIFTNHPASHYGYGMRGGYGCHCHCGCCCWQQ
What are the official names of this protein?
Uncharacterized protein MJ0756.
Protein: RPOB_PHYAS
Sequence: MAYRNVKYGKKVERRNYSKIIYDVDLPNLIEIQNKSFNWFLKDGIEELLQDFCPIESYNGDLKIYFGECYSTGPKYSVEESKTKDASYVIQLFVKATLENTLTGETKKSSVLLTELPLITDTGTFIINGKERVAVSQIVRSSSVYYSSTFDVKLNKNLYSGQVIPARGAWIEYEEGSKEILYVKLDRSKKIPLSNFIYALGFNNREIIEKVFGKSPLLNSSFVKEEDMDTGNALIELYSKIRQGEKVPVDTARDFIRKRLFDQKKYDLTTVGRYKFNKKLDVLARAEKTYLVHDFVNLETKEIILPKHTFLTKDKIEILRKNRHFLLQELFDAQHNLENETDEEILTYKKDPQSRELYIKTNILNFRTGEIIFPKDTLVTDEVIKRLRKSIQLLDGKVIEFFLRSKDVYQKDLERTGVFNEILEVYLSKDEHDNLQHKVQIVGNNQKETKKHITLSDIIASISYYLNLYEGIGNVDDIDHLGNRRLRLIGELLKNQFRIGLTRAEKHIKDMISVSKFSEVGPGELVNFGFLNGVIKTFFANSRLSQFMDQINPLAELTQKRRVSALGVGGINRDRAGVEVRDVHNSHYGRLCPIETPEGPSIGLIASLAIYAKVDDYGFIQTPFFKVFVQNGASYVSNQIEYLTADQEKEEIIASSGYELNSDATFQKDKVIARKNGEIGIYPKEQVTYADISPKQIVSIATASIPFLEHNDSSRALMGSNMQRQAVPLLVTESPIVGTGIEYRAAKDSGSLIIASQPGIVTYVDAKKIVTSDQEGNKKEYQLTTFEKSNQDTLILQKPIVSLGDNIQKGDILVDGPSTNQGELALGRNILVAFMTWEGYNYEDAIIISEELVKNDVYTSVHINKYSVQTRELKKGSGKEEITREVPNVGADAIKNLDERGIIIPGSEVKEGDILVGKITPQGNVDPTPQEKLIQIVIGEKAREYKDSSLRVPYGEGGIVQSVQYFSRKNGDILPPGVNENIRVFIAKKRKISEGDKMAGRHGNKGVISRILPKEDLPFMEDGTTIDVMLNPLGVPSRMNIGQILEIHLGMSAKNLNIKVATPVFDGVNDQDLKEISQEANLELDGKKVLYDGRTGEPYENRISVGVMYMIKLSHMVDDKLHARNVGPYTLVTQQPMRGKIREGGQRYGEMENWAVHAHGAAYTLQEFLTIKSDDIIGRNQTYSAIVQGKQLPKPNIPESFRVLIKELQALGLYVELIKTDTKENEVNKSLIDYKKEGYN
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: CABP5_BOVIN
Sequence: MQFPMGPACIFLRKGIAEKQRERPLGPDEIEELREAFLEFDKDRDGFISCKDLGNLMRTMGYMPTEMELIELGQQIRMNLGGRVDFDDFVELMTPKLLAETAGMIGVQEMRDAFKEFDANGDGEITLGELQQAMQRLLGDKLTSQEISEVVQEADINGDGTVDFEEFVKMMSR
What is the function of this protein?
Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity).  Involved in the transmission of light signals (By similarity).  May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity).  May play a role in the extension and network organization of neurites (By similarity).
What are the official names of this protein?
Calcium-binding protein 5, CaBP5.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ASA1_KLULA
Sequence: MPFTLRYHTCGVTSLLHWNDEQDVPTLISGDEKGSILVWNLLSRKPYYKYTCRGQIVSFQQLNDLIIATSKDHTLRILKFPSTLTTKEGFPDYSLPELELIYEIPVNTLNFANTAVEQVDTNNYRLWCCNTQDSETIDIYEFDLRDSKSLKRIHRALSLYEVISGLVDPSTMKFDKLGTTMKFIIYEGIIYLGFESGFVIGLRLTQGLHIVYISSANYPEPVLDLTVGKDLGKVISSSTNSSLGLHTPNINTESHNNVSSKDVVVDDSTIHSEMVNIPINKVSHIQQVDNLLIAASWSGRTVVFDINGNKVLASILKERGQVLIDDNPYGNASLPENSTKVKISAMTCIPKFNTVNPSCTSEGTRRRWIRFYKETWCLIGYADGSIKATEVTFDNLITA
What is the function of this protein?
Component of the ASTRA complex involved in chromatin remodeling.
What are the official names of this protein?
ASTRA-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat ASA1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PTH_SYMTH
Sequence: MAKLIVGLGNPGPRYAATRHNAGWMLLDAFARKHGVAIEQRGFEGLYGELRWGAEAEKVILLKPLTYMNLSGRSVAQAARFYRIAPADILVLFDDLDLEPGRLRLRAKGSAGGHNGVKSVIAELGTAEFPRLRIGIGRPAPGWEVIDWVLAPFGPDDAAAVAAALPRAVEAVECFLTEGILAAMNRYNT
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFPL_SALPB
Sequence: MPRANEIKKGMVLNYNGKLLIVKDIDIQSPTARGAATLYKMRFSDVRTGLKVEERFKGDDIVDTVTLSRRGVDFSYVDGNEYVFMDKEDYTPYTFTKDQIEEELLFMPEGGMPDMQVLTWDGQLLALELPQTVDLEIVETAPGIKGASASARNKPATLSTGLVIQVPEYLSAGEKIRIHIEERRYMGRAD
What are the official names of this protein?
Elongation factor P-like protein.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
Protein: Y1588_MYCTO
Sequence: MLANSREELVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHTLINQLDTQASEEELGGTLCCALANRLRITKPDAALRIADAADLGPRRALTGEPLAPQLTATATAQRQGLIGEAHIKVIRALFRPPARRGGCVHPPGRRSRPGRQSRSISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL
What are the official names of this protein?
Uncharacterized protein MT1623.
What is the protein family that this protein belongs to?
Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.
Protein: MURA2_PROMA
Sequence: MQVLESQKLSGHIRVSGAKNSSLVLMAAALLADRSVFLSNVPLLTDVEVMSKLLVSMGVELRRNKNQLEIMTSGLSLFSKDLSCEAFHSLRASFFCIGPLLARFGEAKIPLPGGCRIGARPIDEHIQALKALGARVEIQNDYVVAKAISPQKRLIGARIRFNCKSVGATETILMAATLSQGTTILENTAEEPEIQDLATMLNEMGAKIQGAGTSQITIEGVDRLKGCSYTVMPDRIEAGTFLVAAAITRSPLTISPVVPEHLEAVILKLQECGCLIEYSGNTLSVIPRKNLQAVDITTRPFPGFPTDLQAPFMALMTTVKGISKIQETVFENRMQHVGELQRMGATIVLEGNTAVVIGGNNLKATSVTGGDLRSCAAMVLASLAANGTSVIQGLEHLDRGYEDFAEKLNAVGANISRTHSVPLSSQE
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2, Enoylpyruvate transferase 2, UDP-N-acetylglucosamine enolpyruvyl transferase 2, EPT 2.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_STAA8
Sequence: MSKVHVFDHPLIQHKLSYIRDVNTGTKEFRELVDEVGMLMAYEVTRDLELQDVDIETPVTKMTAKRLAGKKLAIVPILRAGLGMTDGILSLVPAARVGHIGLYRDPETLKAVEYFAKLPQDITERQIIVVDPMLATGASAIEAITSLKKRGAKNIRFMCLIAAPEGVEKMHEAHPDVDIYIAALDEKLNDKAYITPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: CRBN_DROME
Sequence: MDEEENSEINSVQARDEDVQLEDQQSQGLQDRQVDVIEQAWNNAMPDEPSPPAEDAFQDPLATDGEGGDALEAMVENVLQDDTASEGSHPSSDMSLESPGSEDDSDLESLPHWMIPQNRLRSAVDMMVSQARNRDGGIAALLSGDNFLQRVRSMVFSQERRRSRTSEETSQEAAEQPVDPPPQQPPRPPIDIGFDTNLPAEHSYFGNHLSRVPGVDYLEVGSVHHMLIFLHQHILFPGEVLPFMIDGRMFDEDMPGLDGLIFGVSFPRLQPPEDNPHKLYGVTCQIYERGESGRGLVFYKSRALQRIVINCDDIKGSPQYIARNPTSKCFSKVKILPEYFLPEPLQTVDMGSMARFRDIPSMRDKYRRFQLSTTTWPSDACQEYSFSSIVERARQRLESQKIDTMPKCPIQLSFWLVRNLHLTEKMMRLTFLTDSVNTRLQLIKSTFKDETLFFCRYCNSSLALCSDLFAMSKHGVQTQYCNPEGYIHETNTVYRVISHAIGYSGEPSTKFSWFPGYQWHIILCKFCAQHVGWEFKAVHPNLTPKVFFGLAGSSVRIGKASEYSPFNGTTYVVRNMMRMISSDME
What is the function of this protein?
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (Probable).  Has an essential role in mediating growth by negatively regulating insulin signaling (PubMed:27702999).  It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae (PubMed:29530986).
What are the official names of this protein?
Protein cereblon, Protein ohgata.
What is the protein family that this protein belongs to?
Belongs to the CRBN family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ATPD_SHIB3
Sequence: MSEFITVARPYAKAAFDFAVEHQSVERWQDMLAFAAEVTKNEQMAELLSGALAPETLAESFIAVCGEQLDENGQNLIRVMAENGRLNALPDVLEQFIHLRAVSEATAEVDVISAAALSEQQLAKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: BACR2_HALMA
Sequence: MLPLQVSSLGVEGEGIWLALGTVGMLLGMVYFMAKGWDVQDPEQEEFYVITILIAGIAASSYLSMFFGFGLTEVELVNGRVIDVYWARYADWLFTTPLLLLDIGLLAGASNRDMASLITIDAFMIVTGLAATLMKVPVARYAFWTISTIAMLFVLYYLVVVVGEAASDASEEAQSTFNVLRNIILVAWAIYPVAWLVGTEGLGLVGLFGETLLFMILDLTAKIGFGFILLRSRAIVGGDSAPTPSAEAAD
What is the function of this protein?
Light-driven proton pump.
What are the official names of this protein?
Bacteriorhodopsin-II, HmBRII.
What is the protein family that this protein belongs to?
Belongs to the archaeal/bacterial/fungal opsin family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TPIS_MESM1
Sequence: MRKKIIIGNWKMNKTKTEAENFVKEFNKITSELNLKLDKNLVAGLALPFTSLGIKKEGNFANLVIAAQNFHQNNSGAFTGEISAEMLLDLGVKMVVLGHSERREFFHETDEIVNMKMHQAIKNNLVPIVCVGETELQYNSNKSKEVIKNQIEKSLKNLSDFSKIIIAYEPIWAIGTGKTATVEYAQEMCKYIRSLTNEKTIIQYGGSVKPNNIKELLSQKDIDGALVGGASLNVKDFIDLIK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
Protein: RS16_XANAC
Sequence: MVKIRLTRGGAKKRPFYHIIVTDVRSARDGRNIERLGYYNPVAQGAEPRIVLDVARVDHWVGNGAQLTDKVRNLYREAKSQAAAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: OMCBC_CHLTH
Sequence: MNKLIRRAVTIFAVTSVASLFASGVLETSMAESLSTNVISLADTKAKDNTSHKSKKARKNHSKETPVDRKEVAPVHESKATGPKQDSCFGRMYTVKVNDDRNVEITQAVPEYATVGSPYPIEITATGKRDCVDVIITQQLPCEAEFVRSDPATTPTADGKLVWKIDRLGQGEKSKITVWVKPLKEGCCFTAATVCACPEIRSVTKCGQPAICVKQEGPENACLRCPVVYKINVVNQGTATARNVVVENPVPDGYAHSSGQRVLTFTLGDMQPGEHRTITVEFCPLKRGRATNIATVSYCGGHKNTASVTTVINEPCVQVSIAGADWSYVCKPVEYVISVSNPGDLVLRDVVVEDTLSPGVTVLEAAGAQISCNKVVWTVKELNPGESLQYKVLVRAQTPGQFTNNVVVKSCSDCGTCTSCAEATTYWKGVAATHMCVVDTCDPVCVGENTVYRICVTNRGSAEDTNVSLMLKFSKELQPVSFSGPTKGTITGNTVVFDSLPRLGSKETVEFSVTLKAVSAGDARGEAILSSDTLTVPVSDTENTHIY
What is the function of this protein?
In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin.  It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity).
What are the official names of this protein?
Large cysteine-rich periplasmic protein OmcB, serovar C, Large-CRP, 60 kDa CRP, 60 kDa outer membrane protein, Cysteine-rich outer membrane protein.
What are the subcellular locations of this protein?
Periplasm.
Protein: SPEE_ACET2
Sequence: MELWFTEYQTPTLGITCKTKKTLHSEKTEYQELAVIETEQFGRMLLLDGIIQTTVADEFVYHEMIAHVPLFTHKNPKKALVVGGGDGGSIREIVKHPSIEKAVLCEIDRRVIEVSKEYLPEISCALDNEKVEVVVGDGIKYVKEHKNEFDVIIIDSTDPIGPAEGLFAIDFYRAVYDCLKEDGIFVAQTESPFIDKELITRIIRDVKSLFPITRLYTCAIPTYPTGYWCFTMGSKKYDPLETDIDSIPDIDTKYYCPQIHRAAFILPKFAKELIK
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDC_RAT
Sequence: MPSANASRKGQEKPREIVDAAEDYAKERYGVSSMIQSQEKPDRVLVRVKDLTVQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIIDVEGIVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEVEGEEDGRATVNQDTRLDNRIIDLRTSTSQAIFHLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKSNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMDDEEDLSTPNEKLLGRLVKEKYDTDFYVLDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP
What is the function of this protein?
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
What are the official names of this protein?
Aspartate--tRNA ligase, cytoplasmic, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZAPA_SALTI
Sequence: MSAQPVDIQIFGRSLRVNCPPDQRDALNQAADDLNQRLQDLKVRTRVTNTEQLVFIAALNISYELTQEKAKTRDYAASMEQRIRMLQQTIEQALLDQGRITEKTGQNFE
What is the function of this protein?
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.  It is recruited early at mid-cell but it is not essential for cell division.
What are the official names of this protein?
Cell division protein ZapA, Z ring-associated protein ZapA.
What is the protein family that this protein belongs to?
Belongs to the ZapA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes at mid-cell.
Protein: GLYA_LACLS
Sequence: MIFDKEDFESFDPELWAAIHAEEIRQQQNIELIASENIVSKAVMAAQGSVLTNKYAEGYPGKRYYGGTEAVDVVENLAIDRAKELFGAKFVNVQPHSGSQANAAAYMALIQPGDTVLGMDLNAGGHLTHGASVNFSGKTYHFVPYGVNPQTELLDYEEILKIAKEVQPKLIVAGASAYSRLIDFAKFRQITDSVGAKLMVDMAHIAGLVATDAHPNPLPYADVVTTTTHKTLRGPRGGMILTNDEVLAKKINSAIFPGTQGGPLEHVIAAKAVAFKEALDPEFATYIEQVIKNTQAMADEFAKVEGLRLIAGGSDNHLLNLKVLDLGINGKEAQDLLDSVHITLNKEAIPDETLSPFKTSGVRIGAAAITSRGFKEAEARKVAQLVSNALVNHDNQEKLEEVRKAALELTHQFPL
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTL_HUMAN
Sequence: MLFNSVLRQPQLGVLRNGWSSQYPLQSLLTGYQCSGNDEHTSYGETGVPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTESQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGFYRQVNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFLYPGSSTRKLGYSSLILDSTGSTLFANCTDDNIYMFNMTGLKTSPVAIFNGHQNSTFYVKSSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCPSDFTKIATCSDDNTLKIWRLNRGLEEKPGGDKLSTVGWASQKKKESRPGLVTVTSSQSTPAKAPRAKCNPSNSSPSSAACAPSCAGDLPLPSNTPTFSIKTSPAKARSPINRRGSVSSVSPKPPSSFKMSIRNWVTRTPSSSPPITPPASETKIMSPRKALIPVSQKSSQAEACSESRNRVKRRLDSSCLESVKQKCVKSCNCVTELDGQVENLHLDLCCLAGNQEDLSKDSLGPTKSSKIEGAGTSISEPPSPISPYASESCGTLPLPLRPCGEGSEMVGKENSSPENKNWLLAMAAKRKAENPSPRSPSSQTPNSRRQSGKKLPSPVTITPSSMRKICTYFHRKSQEDFCGPEHSTEL
What is the function of this protein?
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.  The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2 (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613, PubMed:27906959).  CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480).  CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548).  KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445).  Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation.  In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613).  The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1 (PubMed:26431207).
What are the official names of this protein?
Denticleless protein homolog, DDB1- and CUL4-associated factor 2, Lethal(2) denticleless protein homolog, Retinoic acid-regulated nuclear matrix-associated protein.
What is the protein family that this protein belongs to?
Belongs to the WD repeat cdt2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome. Note=Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.
Protein: FTCD_DICDI
Sequence: MNKLVECVPNFSEGRDQTIIDAISKAIRDTAGCTLLDVDPGKSTNRTVYTFVGCPDSIVNGAINATKVAFKLIDMTKHHGEHPRMGALDVCPFVPVRNVTMEECVNCSKEFGKRISEEIGVPIFLYEEASTQSYRKQLKQIRQGEYEGLEEKLKEEKWKPDFGPAKFIPSYGASVTGARSFLIAYNVNILGTKEQAHRIALNVREAGRGDNEPGRLKFLKGIGWFVDEYNLAQVSMNLDNYRETGVHTVFEECSKDARELNLGVAGSEIVGLVPLEAILMAADYYIAKENLFIIDEALKVRLAIERLGLSSCSFFDPKKRIIDYMVQEDLKVTQPLASMSVRGFVELLGSRTPAPGGGSASALIAAMGAGLGAMTGWMTFGKKKFEALDSIMRELLPPLDKAMRDLIPYIDADTNAFNDYIKAMGTPKGPQRDIAIDKALKQAINIPLSTMKISNTCWGPLLKMAQYGNLASKSDLEVGCKSLETGIWGAHRNVSINLLDCKDAQFVESTTKEANEILKNAQESLQKVLEILSNRKE
What is the function of this protein?
Folate-dependent enzyme, that displays both transferase and deaminase activity.  Serves to channel one-carbon units from formiminoglutamate to the folate pool.
What are the official names of this protein?
Formimidoyltransferase-cyclodeaminase, Formiminotransferase-cyclodeaminase, FTCD, p60.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the formiminotransferase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Protein: ULAE_SALTY
Sequence: MLSKQIPLGIYEKALPAGECWLERLRLAKTLGFDFVEMSVDETDARLARLDWSREQRLALVSAVAETGVRVPSMCLSAHRRFPLGSEDDAIRAQGLEIMRKAIQFAQDVGIRVIQLAGYDVYYQQANDETRCRFRDGLKESVDMASRAQVTLAMEIMDYPLMNSISKALGYAHYLNNPWFQLYPDIGNLSAWDNDVQMELQAGIGHIVAVHVKDTKPGVFKNVPFGEGVVDFERCFETLKQSGYCGPYLIEMWSETAENPAAEVAKARDWVKARMASAGLVEAA
What is the function of this protein?
Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate.  Is involved in the anaerobic L-ascorbate utilization.
What are the official names of this protein?
L-ribulose-5-phosphate 3-epimerase UlaE, L-ascorbate utilization protein E, L-xylulose-5-phosphate 3-epimerase.
What is the protein family that this protein belongs to?
Belongs to the L-ribulose-5-phosphate 3-epimerase family.