PharMolix/UniProtQA huggingface dataset:
Protein: PHNC_ECOL5
Sequence: MQTIIRVEKLAKTFNQHQALHAVDLNIHHGEMVALLGPSGSGKSTLLRHLSGLITGDKSAGSHIELLGRTVQREGRLARDIRKSRANTGYIFQQFNLVNRLSVLENVLIGALGSTPFWRTCFSWFTREQKQRALQALTRVGMVHFAHQRVSTLSGGQQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYALRYCERIVALRQGHVFYDGSSQQFDNERFDHLYRSINRVEENAKAA
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: AVT3C_ARATH
Sequence: MGFQNEASSSSYTLKIPPPAREDSPLLGKGPPLSSQFKTFANVFIAVVGAGVLGLPYAFKRTGWLMGVLLLVSVSVLTHHCMMLLVYTRRKLDSFNAGISKIGSFGDLGFAVCGSLGRIVVDLFIILSQAGFCVGYLIFIGTTLANLSDPESPTSLRHQFTRLGSEFLGVSSKSLYIWGCFPFQLGLNSIKTLTHLAPLSIFADIVDLGAMAVVIVEDSMIILKQRPDVVAFGGMSLFLYGMGVAVYSFEGVGMVLPLESEMKDKDKFGKVLALGMGFISLIYIAFGILGYLAFGEDTMDIITANLGAGLVSTVVQLGLCINLFFTFPLMMNPVFEIVERRFSRGMYSAWLRWVLVLAVTLVALFVPNFADFLSLVGSSTCCVLGFVLPALFHLLVFKEEMGWLQWSSDTAIVVLGVVLAVSGTWSSLSEIFSVKV
What is the function of this protein?
Translocates preferentially neutral amino acids from the vacuole to the cytoplasm.
What are the official names of this protein?
Amino acid transporter AVT3C, AtAvt3C, Aromatic and neutral amino acid transporter-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.8) subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein.
Protein: METE_MYCA1
Sequence: MTPQAFTATVVGSPRIGPKRELKRATEGYWAGRTGRAELEKVAATLRRDTWAGLAAAGLDSVPVNTFSYYDQMLDTAVMLDALPERARQVSDDLDRYFAAARGNSDVAPLEMTKWFDTNYHYIVPEIAPTTKFALNPDKVLSELKEALAQGIPARPVVIGPITFLLLSKGVDGAGGPIERLEELVPIYAELLSLLADNGAQWVQLDEPALVTDMCADAPALAEAVYNKLGSAANRPAIYVATYFGDPGASLAGLARTPVEAIGVDLVYGPDTAVAAVPELAGKTVVAGVVDGRNVWRTDLAAALDKLTTLLGSAARVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGREKVAEVVTLARALRDGREAVADEIAASNAAVASRKSDPRLHNDRVRARIDSIVASGSHRGDPAQRRASQDARLHLPPLPTTTIGSYPQTSAIRKARAALRSGEIDQAEYERRMKKEIADVITLQEQLGLDVLVHGEPERNDMVQYFAEQLEGFFATQNGWVQSYGSRCVRPPILYGDVVRTHPMTVEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQAAGIAVIQVDEPALRELLPLRRADQEEYLRWAVGAFRLATSGVADSTQIHTHLCYSEFGEVIGAIADLDADVTSLEAARSHMEVLDDLNAVGFSNSVGPGVYDIHSPRVPSTAEIAESLRAALRAVPAERLWVNPDCGLKTRNPDEVSASLKNMVAAAHEVRAGV
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: KDSA_PROMH
Sequence: MQHKVVSIGDIKVANNLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLDIPYVFKASFDKANRSSIHSYRGPGLDEGMKIFQELKETFGVKIITDVHEPSQAQPVSEVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVEKFKEGGNDQVILCDRGSNFGYDNLVVDMLGFHVMMQASEGAPVIFDVTHSLQCRDPFGAASGGRRGQVAELARAGMAVGLAGLFLEAHPDPDHARCDGPSALPLAKLEPFLAQIKAIDSLVKSFPELDTSK
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPK14_ARATH
Sequence: MAMLVDPPNGIRQEGKHYYTMWQTLFEIDTKYVPIKPIGRGAYGVVCSSINSETNERVAIKKIHNVFENRIDALRTLRELKLLRHVRHENVISLKDVMLPTHRYSFRDVYLVYELMDSDLNQIIKSSQSLSDDHCKYFLFQLLRGLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTYEQFMTEYVVTRWYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLIINVVGSQQDWDLQFIDNQKARRFIKSLPFSKGTHFSHIYPHANPLAIDLLQRMLVFDPTKRISVSDALLHPYMEGLLEPECNPSENVPVSSLEIDENMEGDMIREMMWEEMLHYLPRA
What are the official names of this protein?
Mitogen-activated protein kinase 14, AtMPK14, MAP kinase 14.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Protein: YQGF_DESRM
Sequence: MRIMGLDVGDKTIGVALSDPLGWTAQGLEVIRRDTIEKDMNRLAQIISEYSVERILVGMPKNMNGTVGSQGEKVLAFIEKVKEKIDLPIKTWDERLSTVAAEKMLIQADVSRGKRKKVIDKMAAAVILQGYLDSGAK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDPA_KLEP7
Sequence: MSLDIDQIALHQLIKRDEQNLELVLRESLLEPNATVVEMMAELHRVYSAKSKAYGLFNEESELAQALRLQRQGEEEFLAFSRAATGRLRDELAKYPFAEGGIVLFCQYRYLAVEYLLVAVLNNLSSMRVNEELDIRSTHYLDINHADIVARIDLTEWETNPESTRYLTFLKGRVGRKVADFFMDFLGASEGLNAKAQNRGLLQAVDDFAADAQLDKSERQNVRQQVYAYCNEQLQAGEEIELESLSKELAGVSEKSFQEFTAEQGYELEESFPADRSTLRQLTKFAGSGGGLTINFDAMLLGERVFWDPATDTLTIKGTPPNLRDQLQRRTSGGN
What are the official names of this protein?
Nucleoid-associated protein KPN78578_25800.
What is the protein family that this protein belongs to?
Belongs to the YejK family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: EXL1_CAEEL
Sequence: MPTFSLWLPAGSNNVHPCGDPYAHHLFMRCLYHAKHDPTMKFDVKTTNVNKTSQEFKNTGLRRMPGISAEESGETQTFETEDDILDFLEYLKPERGDDEEAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPRLSAKDRAKLVREEPVFSFSV
What is the function of this protein?
Probable chloride channel.
What are the official names of this protein?
Chloride intracellular channel exl-1, Exc-4-like protein.
What is the protein family that this protein belongs to?
Belongs to the chloride channel CLIC family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Lysosome membrane. Golgi apparatus membrane. Note=Can be translocated to membranes, possibly as integral membrane proteins, with chloride channel activity (By similarity). Localizes to lysosomal membranes in the intestine, and to Golgi apparatus in neurons and muscle. It also localizes to dense bodies, a transmembrane structure which links the muscle cytoskeleton to the neighboring hypodermis.
Protein: PHS_VIBC3
Sequence: MLDELRCEACSAGAIGLTSEEQQQLLSELDGWALIHRDGIAQLEKRYRFKNFKQAWAFSNQIAELAEQEFHHPAILLEWGNVTVTWWSHSIKGLHKNDFICAAKCDALT
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: AMA3_ALLMI
Sequence: MALENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRAMHMKEYPDYKYRP
What are the official names of this protein?
SRY-related protein AMA3.
What are the subcellular locations of this protein?
Nucleus.
Protein: RGS20_MOUSE
Sequence: MRTANGGPRARASPSASPADPGLPEGSERTEMRMRQMCGGSETQGPAPSQQGGRGSNACCFCWCCCCTCSCLTVRNQEDQRPQRASHEIRTDIPACEESPTPTLEEVCAWAQSFDNLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKREANKSTIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMVDPSQHIFDDAQLQIYTLMHRDSYPRFMNSTVYKDLLTSLAEKTVEA
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.  Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities.  The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein.  Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
What are the official names of this protein?
Regulator of G-protein signaling 20, RGS20, Regulator of G-protein signaling Z1.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation.
Protein: BIOF_AERS4
Sequence: MNGLAVKGPFVLGAALAERELAALLRRRTATDGSVGGRLQVAGRDYLNFSANDYLGLADHSTIKAAFKEGIDCYGTGSGASPLVTGYSRAHQQLEETLADWLGVEAVLLFNCGFSANQAVLKALLGKDHLLWQDRLNHASLQEMGSQLPCKMKRFGHNDMTALERQLEPNRGLIVSEGVFSMDGDQGPWPELARLAAQSGNWLMIDDAHGLGVLGPEGRGTLAAQGVAPASVHIQMGTFGKALGVAGAFVGGSRELVDYLVNFARHYVYSTHMPTAQACAVSKSIELVRAADESRAHLARLITRFRQGTAALGWQLGASDTPIQPLLVGESSAALQLAARLRDRGVWVSAIRPPTVPVGTARLRITLSAAHREQDVDRLLKALGPCSGSASWEGIHHG
What is the function of this protein?
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
What are the official names of this protein?
8-amino-7-oxononanoate synthase, AONS, 7-keto-8-amino-pelargonic acid synthase, 7-KAP synthase, KAPA synthase, 8-amino-7-ketopelargonate synthase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Protein: PEPE_SHIF8
Sequence: MELLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTEKTAAVLAPLGVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATLGGPNTTYVFKAGEEAVPLEAGHRF
What is the function of this protein?
Hydrolyzes dipeptides containing N-terminal aspartate residues.  May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
What are the official names of this protein?
Peptidase E, Alpha-aspartyl dipeptidase, Asp-specific dipeptidase, Dipeptidase E.
What is the protein family that this protein belongs to?
Belongs to the peptidase S51 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBBA_MYCMM
Sequence: MTRLDSVERAVADIGAGKAVIVIDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVPLDGAVCDRLGLLPMYAVNQDKHGTAYTVTVDAKNGVGTGISASDRATTMRLLADPASVAEDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAREGRGVVLYMRGHEGRGIGLLHKLQAYQLQDAGDDTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDRMGHDLTGLDDFHESVHLPGEFGGAL
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
Riboflavin biosynthesis protein RibBA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Protein: Y684_MYCPN
Sequence: MFSFFKQIFKSLKKFFFLLFGIIFVLFSIIFLETSILQLSNNLVNTYTALVQKTNSSDIVAPAIFKESSPVYKTELKEEKRHFSKIKLTEKKINFIWPYQESDFGSDSEKKDSTTKSSDNNPRKGDVNDKDKLFLARKRGILKAYGEANIAEKRIYKGLAVSFQNTYSFTGTDQESNNLNQNTVSDPQNLIYDKEGNLLGYFVDGLILDGIPLRAGIARFPGDKGKGEDKKTTKKKSEIKQASSATTVLQPLAAQAKMTDAKETTNNEEPKKDSNVEEQYTTNNKDKVWFKSDETQAGSSSGESETSKLSTSYLFTGGQEAANWFPNLYANVPIVLPISPGSQFWLETNPFKEIIEVFQKEKEEKEKQSFSLTFTLDTSKLSHLDKEEFDWLEKQAETISSGSSFGDYNLKKKINSLKSFELNINKDWLKNKVKAEKETILDSLPGFSNSDKNTIFSTQSGDAKSGTQSNPSSLIALRSSVSFKPQLQQTNVALAQQQQDKQESSADDGVKDPTFSDVQTEFDKIGTENHTPQKNLNNVYAALLHQWKSIFQEDLVKKVTALLEKYRDAFLKAKALKELEFSRQNLAIATNVSSEESASFLVSNKDSQKYNDLSIIEGINFKSWLAKEKSNPLDMVYGGKSNSEGFLEKVEYEFKPTQTDEKKKAAAKTTQGTTDSLTQLADASSSSSSSSTGDTKSTSTKFQIYPKLANILAQAQLPEASSIPDTLTNAIKQWSTLDKKGFEALDDTGKSKAANNYVALLSYFTPEFQDPNELVVTNRQKLDIPIIFKNGVNPLTLPTDQQSLVVQTPEAHGAVVSQQWLFKHDKEVLPLEGEYSWKEALENPKNLPNWLNDLPDKYKFSINGLTFAILGVGESVETGYPVLSTNSPLPNSQDEGLIFLNEQGYRSVLFAVPAASEENYYAFKSDDIKAKFPGQDPIQVVASKLKGYLNVPDSDLAFNVKDISKFQYLTTARNYFPDLVQNYLAIASVVIAAFLSILALYLTILLIKSFIKKNQTEFSIIRAGGFSTAKFIAGMSVFAGIVALASSFFGVLFAFLLERQVKGIISRYWFIALPANSFNWISFFGSMLLIFVIFQFISWIAFKQLFSKPVNVLIDQGNETKFSVFLHLLKRKSYTMTPLGKFRVSLIISRLSRLFTYVGLSSIALLLIGIAGTIPQKFGAAQSNTVLNRNFNYRLNLQTPTEQSGWYAIQPYSRFGQTDDSLGIKALYKDKGDQIQQQQQQQQQQGNDKEHPYNLKELKISDRGGNPIKHNGKEIELGNLLLPSFGGAQQLNTDENFFRHASLSKWLIDFPIRVGGANINPWEIVEKSIPKQITQLLSASSDQFLIAVLTDDYFNNLNNNGFLTRNPRTNFIQLDAARVLTQINVFNPGGVKFNEQFLKFLTKVYGDPELSYQDSKLTYGIVPVDPQIEETYTYVQGPFGFKETELNPDSPYTLTGISPDSKFVNLTDSGGNSLRSLISSDSEMNVIVNAGFQYANNTKIGDFIFIQPKNTATRYSEKFLKSPPKTPTVKFRVVGVSTDAFGQELYINQNIANRLLKLNGFDGRGVIKDVVKDGQSTDDSGGTSSGGGSCGGGSTSSTTKDKYKIEYVKPTGYVPFNGVFSKELNPSLVSKALVLNSNIGVWGNFTDFGNNFTNLVKGKENKIITSILPSDPDILKQLAKEKGENGVDSMTYENLRKKVIEKYTSEWSSTQSLASGARGIFGDNIMVPALKLDAAGASAQIIRNNAEVLFNTVNQVDGFLLGTIIPFIFITCVVLGISMLEEMKRIFISLKSIGYKDSQNLVSLLCFFIPAFVLSLLISIAILAGLLVGVQALVFGVAQVFLTNVFEFLPYMVGIVLFGATIFVIGSYFWIKLRSAELKEGF
What are the official names of this protein?
Uncharacterized ABC transporter permease MG468 homolog.
What is the protein family that this protein belongs to?
Belongs to the ABC-4 integral membrane protein family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TINC_DROME
Sequence: MGGKHQGSGAGASSGGGSLNSSLCNSVMTNATTASSSLTQQQQQLQAKYIKSKRHQSRYTSLQHSGHDSGSYLHLNSLWSIWYGVMLTLFQGYLAMHGAYRFLGCSLIPWKIEPVAELNLQIVLSGVVFILLPVFFTSAVFKVGNLANDGIKLATGARERRCTLSPHDGLEEESRGGTLRALWTHGGPTAAFVHIVIALCLLLPRLLLEARIIENGLLPKEQIWATELDFVVINRRNLMAMSVVGATPFPRHHQPSNQQQSHHQHGRLNLTANSLEQDEEDYFNDTMFTAIRGVPAGGNNNLFDLRPDRMANGRKAAKTTATTRTTTTANKLDAGKGQYFEVPDLINQDIDEEERQELEEAIRGEEDDGDEGVGVGEEGTVIMPDFDELAPRTAVGTSTTTAKASSDADKLNVENWQQLGTLGKADASSSSSSTTSTTTTTTTSTTTTAATTTSTRGTSTTTTTTTIKPMEITTSRQSAHHHHGKSRKHHKHHNKQRQQQPPRRHHVASHEQAILESFPEEETTTRDSSIHRVRPEVLPELPIPSTPVSASNSKIIAIKAKNQKRRISKRAAGVEIEPEYLLGDANINSSEFVAKSNEEEPEESEDFELEDGDFQAVPALTPAPPAEPNGPKSGQDYVRLDGFAGMLQLFFGIDKPIDVAIFSQPPSAEFVNLLCALLVWSVRYPAVFWNTSKAFACVFSLQMVVAALDIILGYVGISNLYKLQIYAEAMPVHQPGLILNAVVTLALYLLSTALVLASSMVMYLYGHGRLATRMRDRSIITLKTHQTWIYFAHCASLCFVLALAVVKAPLLNDLSATYKNNLHCPTFLAALVGVTHLLLWIVIWLCLTIKRRWHFKLPPLDSTYGGLLGKSSAQPLLMSSGQRTGSNSSSSGCNSTSTTVNGGDSKPDMMSTATSTELGMGMGMGIGGGINGGMGGTGMGLAAQEDIYWPKLTPSSPKLKVTFNEVTSTSDDVLLIGDQEQTDGKRHTSRGASVCFASATGEVDDGEYATLRAATAGAVVGITMGSMKRGLSNTSVGVSLLHLSEYDELPPPPPANLHHQQQQQQQQQQRQAHSFAHGHPHDYANLSGLGGISDDNISEEGKLLACVRDDSITYASTSDLEPPQPSAQAPPPPPPLPIKGAPVPQPPAVMPHSAGIYGRAPQAMPEMMQLSPEHHHNPLQHSLQHPQHHPLQQQQQKQQTPQHPLQQQGNPHQHLVSPLAPVTVAVHTNEAHIASSSTPRCLRRADSGVPNEALTPRSDTTSTTESTNTTSPPERAPSESSSGVHSGEERELEVIIRPRANSKPPPRPPQPPIQEEPYGRCTNMRMSSFNADPAATSSAVINSATLPPQRSVPEQKFDYTAHCSTMPLPVGCHSQQLAGSGNGYASTSAMTSSMGGGGMPPLPPSQVSSFMTPNSMHYANASVALGNVSGQQQPHTTLPNGVRYSNPHFLRRLPHVTKAAESPYGHLGYGAGHHAFAKLPHETHPTIPEDRDSANYSMASDQDCGLYVTAQLH
What is the function of this protein?
Involved in eye morphogenesis.  May be essential for the normal differentiation of ommatidial cells.
What are the official names of this protein?
Protein tincar.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: WEE1_HUMAN
Sequence: MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
What is the function of this protein?
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'.  Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase.  Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur.  Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated.  A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
What are the official names of this protein?
Wee1-like protein kinase, WEE1hu, Wee1A kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SP16H_MOUSE
Sequence: MAVTLDKDAYYRRVKRLYSNWRKGEDEYASIDAIVVSVGVDEEIVYAKSTALQTWLFGYELTDTIMVFCDDKIIFMASKKKVEFLKQIANTKGNENANGAPAITLLVREKNESNKSSFDKMIDAIKESKSGKKIGVFSKDKFPGEFMKSWSDCLNKEGFDKVDISAVVAYTIAVKEDGELNLMKKAASITSEVFNKFFKERVMEIVDADEKVRHSKLAESVEKAIEEKKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVVSDKNHMHFGAITCAMGIRFKSYCSNLVRTLMVDPTQEVQENYNFLLQLQEELLKELRHGVKICDVYNSVMDVVKKQKPELLNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKEGKKPEEKTYALFIGDTVLVDEDGPATILTSVKKKVKNVGIFLKNEDDEEEEEEKDEAEDLLGRGSRAALLTERTRNEMTAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQQIQKARKSNVSYKNPSLMPKEPHIREMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEGDYTYLRINFYCPGSALGRNEGNIFPNPEATFVKEITYRASNMKAPGEQTVPALNLQNAFRIIKEVQKRYKTREAEEKEKEGIVKQDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEAHVNGFRFTSVRGDKVDILYNNIKHALFQPCDGEMIIVLHFHLKNAVMFGKKRHTDVQFYTEVGEITTDLGKHQHMHDRDDLYAEQMEREMRHKLKTAFKNFIEKVEALTKEELEFEVPFRDLGFNGAPYRSTCLLQPTSSALVNATEWPPFVVTLDEVELIHFERVQFHLKNFDMVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSLNWTKIMKTIVDDPEGFFEQGGWSFLEPEGEGSDAEDGDSESEIEDETFNPSEDDYEEEEEDSDEDYSSEAEESDYSKESLGSEEESGKDWDELEEEARKADRESRYEEEEEQSRSMSRKRKASVHSSGRGSNRGSRHSSAPPKKKRK
What is the function of this protein?
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes.  The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair.  During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure.  It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.  The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II).
What are the official names of this protein?
FACT complex subunit SPT16, Chromatin-specific transcription elongation factor 140 kDa subunit, FACT 140 kDa subunit, FACTp140, Facilitates chromatin transcription complex subunit SPT16.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24 family. SPT16 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Protein: CAH6_HUMAN
Sequence: MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
What is the function of this protein?
Reversible hydration of carbon dioxide.  Its role in saliva is unknown.
What are the official names of this protein?
Carbonic anhydrase 6, Carbonate dehydratase VI, Carbonic anhydrase VI, CA-VI, Salivary carbonic anhydrase, Secreted carbonic anhydrase.
What is the protein family that this protein belongs to?
Belongs to the alpha-carbonic anhydrase family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZIPA_SHISS
Sequence: MMQDLRLILIIVGAIAIIALLVHGFWTSRKERSSMFRDRPLKRMKSKRDDDSYDEDVEDDEGVGEVRVHRVNHAPANAQEHEAARPSPQHQYQPPYASAQPRQPIQQPPEAQVPPQHAPRPAQPMQQPAYQPQPEQPLQQPVSPQVAPAPQPVHSAPQPAQQAFQPAEPVAAPQPEPVAEPAPVMDKPKRKEAVIIMNVAAHHGSELNGELLLNSIQQAGFIFGDMNIYHRHLSPDGSGPALFSLANMVKPGTFDPEMKDFTTPGVTIFMQVPSYGDELQNFKLMLQSAQHIADEVGGVVLDDQRRMMTPQKLREYQDIIREVKDANA
What is the function of this protein?
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring.  Also required for the recruitment to the septal ring of downstream cell division proteins.
What are the official names of this protein?
Cell division protein ZipA.
What is the protein family that this protein belongs to?
Belongs to the ZipA family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type I membrane protein. Note=Localizes to the Z ring in an FtsZ-dependent manner.
Protein: RBL_NITS1
Sequence: MASKTYQAGVKEYRQTYWQPDYVPLDTDILACFKITPQAGVDREEAAAAVAAESSTGTWTTVWTDLLTDMDYYKGRAYRIEDVPGDDACFYAFIAYPIDLFEEGSVVNVFTSLVGNVFGFKAIRALRLEDVRFPIAYVKTCGGPPSGIQVERDKMNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGSLDFTKDDENINSQPFMRWRDRFEFVQEATLKAEAETGERKGHYLNVTAPTPEEMYKRAEFAKEIGAPIIMHDYLAGGLCANAGLANWCRNNGMLLHVHRAMHAVLDRNPHHGIHFRVLTKILRLSGGDHLHTGTVVGKLEGDRASTLGWIDLLRESFVPEDRSRGIFFDQDWGSMPGAFAVASGGIHVWHMPALVAIFGDDSVLQFGGGTLGHPWGNAAGAHANRVALEACVQARNEGRQIEKEGREILTAAAQHSPELKIAMETWKEIKFEFDTVDKLDIAHK
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
Protein: TRMB_HAEI8
Sequence: MTQTFADQKRKTVETAEFTEDGRYKRKVRSFVLRTGRLSEFQRNMMNDNWGTLGLDYQTEPFDFAKIYGNDNPIVLEIGFGMGKSLVDMAFANPDKNYLGIEVHTPGVGACIAYAVEKGVTNLRVICHDATEILRDSIADGALGGLQLFFPDPWHKAKHHKRRIVQPHFVTQVIQKLGKNGFIHMATDWENYAEQMLEVLSANTDLVNTSKNGDYIPRPDFRPLTKFEARGYKLGHGVWDLYFVKK
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
Protein: RL5_CHLL3
Sequence: MAQKTETAIPSNSKARFETLYREKVTKALSERFGYKNVMNIPRLQKISINIGVGEAASEPKLLETAIQELAQITGQKPQIRKSKKAISNFKLREGQAIGCRVTLRRKAMYEFFDRFVSLAVPRIRDFRGLSDTSFDGRGNYTIGVREQIIFPEIDIDKIPKICGMDISFVTSAKTDEEAYVLLAELGMPFKKKN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.