PharMolix/UniProtQA huggingface dataset:
Protein: PNP_PROMM
Sequence: MQGQTQSISFDGREIRLTTGRYAPQAGGSVMMECGDTAVLVTATRSTGREGIDFLPLICDYEERLYAAGRIPGSFMRREGRPPERATLIARLIDRPMRPLFPSWMRDDLQIVATCLSLDERVPADVLAVTGASMATLLASIPFQGPMAAVRVGLLGDDFVLNPSYREIERGDLDLVVAGTPDGVVMVEAGANQLPQGDVIEAIDFGYEAVCELIKAQQTILKDAGIKQVQPEPPTQDQDTKLSTYLEKNCSKSIGEVLKQFEQTKAERDSKLDAIKAKTAEAIDSLKEDDAVRKSVNANSKVLSNNFKALTKKLMREQIIKQGKRVDGRKLDEVRPISSAAGVLPKRVHGSGLFQRGLTQVLSTATLGTPSDAQEMDDLNPGPEKTYLHHYNFPPYSVGETRPMRSPGRREVGHGSLAERAIIPVLPPKDSFPYVLRVVSEVLSSNGSTSMGSVCGSTLALMDAGVPLKAPVSGAAMGLIKEDAEIRILTDIQGIEDFLGDMDFKVAGTKDGITALQMDMKITGLPVKTIAEAVNQARPARIHILEKMLEAIDAPRTTLSPHAPRLLSFRIDPELIGTVIGPGGRTIKGITERTNTKIDIEDGGIVTIASHDGAAAEAAQRIIEGLTRKVNEGEVFTGTITRIIPIGAFVEILPGKEGMIHISQLSEARVEKVDDVVKVGDQVTVRIREIDNRGRINLTLRGVPQNGEETQSEPAPTPVAPLN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACEK_POLSJ
Sequence: MFPQRLDSTIAYDIAKAMMDGFNRHYQLFRTESARAKHRFETADWHGQQRAQRERIEFYDLRVREASTRLEREFKAGEQSMDVWHQVKLHYIGLLVNHHQPELAETFFNSVTTKILHRSYFQNDFIFVRPAVSTEYIENEEPTAQPTYRAYYPTRDNLREIIVRLVRDFDLRLEFEDLERDAGYVLEAVSERLSDVKLRANFQIQVLSGLFFRNKGAYVVGKIINGFNEVPLALPILHSKSGKLVIDAALFGEDDLLILFSFARAYFMVDMGIPSAYVQFLRSMMPHMPRAEIYNALGLAKQGKTLFYRDFLHHLRHSTDKFRIAPGIKGMVMLVFDLPSFPYVFKVIKDYYPPQKDTSREQIKGKYLLVKQHDRVGRMADTQEYSEVAFPRARFDDELIAEIEKFAPSQLEISDRDRDGNTEVIIKHVYIERRMIPLNIYLQEAFDAGVGEPAAKNQIERAVVEYGNAIKDLVAANIFPGDMLWKNFGITRHGKVVFYDYDEIEYITDCKFRRVPAPRNDEEEMSGEVWYSVGPKDVFPETFAPFLLGNDAVREVFMKHHGDLLDAEFWQSHQARIQAGHVHDVFPYEREKRFTRRHSPGRNDHELLTHLPPEPMLTGLSGMTP
What is the function of this protein?
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue.  This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon.  When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
What are the official names of this protein?
Isocitrate dehydrogenase kinase/phosphatase, IDH kinase/phosphatase, IDHK/P.
What is the protein family that this protein belongs to?
Belongs to the AceK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KUP_BURA4
Sequence: MNDTIQATDAAHAHSTHQHSMRALAIAAIGVVFGDIGTSPLYALKEAFSPAHGIPLTESSILGVISLLFWAIILVVGIKYLLFVMRADNNGEGGVLALMALSLRPLDSKTRVAGALMALGIFGACMFYGDAVITPAISVMSAVEGLEIATPHLSHLVLPITIVILIALFWIQRHGTALVGKLFGPIMVVWFVVIAALGVYHIARVPGIIAAINPYYAASFMADHLLQAYVVLGSVVLVLTGAEALYADMGHFGAKPIRLAAYGLVMPSLVLNYFGQGALLIQNPKAIENPFFLLAPEWALLPLVVLSTVATVIASQAVISGAYSLTSQAIQLGYVPRMKVLHTSELAIGQIYVPVVNWLLLFVILCIVIGFKSSDNLAAAYGIAVTATMVITTVLACVVMVKVWNWNRLLVGAIIAIFLAIDLGFFGANLLKVAQGGWLPLGIGALLFFLLMTWYKGRHIVKERTAADGIPLEPFLQGLLAHPPHRVSGTAIYLTGNDKLVPVSLLHNLKHNKVLHERTIFLTFVTRDIPYVRDDTRLSSRDAGGGLYIVKAQYGFNETPDVKAVLEEFGRSHDMTFELMDTSFFLARETVVPTHLPGMSIWRERVFAWMHQNAAKPTDFFSIPANRVVELGTKIEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARGA_YERPE
Sequence: MKERSTELVQGFRHSVPYINAHRGKTFVVMLGGEAIEHENFSSIVNDIGLLHSLGIRLVVVYGARPQIDSNLADHNYEPIYHKHTRVTDARTLEMVKQAAGLLQLDITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGVDDGVDYCHSGRIRRIDEEAIHRQLDNGAIVLLGPVAVSVTGESFNLTSEEVATQLAIKLKAEKMIGFCSSQGVTDSEGNIISELFPNDAQKRIEDLEQDGDYNSGTVRFLRGAVKACRSGVRRSHLLSYQEDGALIQELFSRDGIGTQIVMESAEQVRRATINDIGGILELIRPLEQQGILVRRSREQLEMEIDKFTIIERDNLTIACAALYPFPDEHIGEMACVAVHPDYRSSSRGEMLLNRITNQARQMGLKKLFVLTTRSIHWFQERGFTPAEVDVLPIQKQELYNYQRRSKILLADL
What are the official names of this protein?
Amino-acid acetyltransferase, N-acetylglutamate synthase, AGS, NAGS.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. ArgA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL23_STAA8
Sequence: MEARDILKRPVITEKSSEAMAEDKYTFDVDTRVNKTQVKMAVEEIFNVKVASVNIMNYKPKKKRMGRYQGYTNKRRKAIVTLKEGSIDLFN
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: NODZ_HYPPI
Sequence: MITASTSVFGGLILAFIFSLLYKNKKTRIPAEIDRVRTGGFLAHIRAFGCRLGTRVDDIRNGYNKFNKNGKPFVIQDSTFIPQVVIPPQYLGWLKEQPEKALSAETVRLEQLGLRYLVPSSDPEMVHLLTDVVCRYLTRNFQRVQERLYEELHMSTDEIMGLEATEWRQICLHEAMETILRRMISCVLIGLPWCRDEECLKSWTGFLHCMAIAGTILGAVTPWFLRPLLGLLLKPPVGYMRRRSLRYLTPIFTERWKKIEKHEKSSLTTRELPDDFVTWCIQEVRNGAAEVTMLDLLSADPTIGYWEKLVEEATTAFRTDEDWIHAGTVSKLAYTDSAIRESLRRNPFSIRNVTREVIGKDGLTLPSGTRLPQGTWITTALANIHHDARFYSNPTEYQPFRFVARDAFHTEGKEGSEKVLQPSEAILTSTIDERLLTFGYGRRACPGRWFASHILKMLIAYITINYDIQPLTGPPKKVKFADFTVPSPSIKIIVRRKNLAYLRQRER
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes nodulisporic acids (NA).  Nodulisporic acid A (NAA) and its chemically modified derivatives are of particular significance because of their highly potent insecticidal activity against blood-feeding arthropods and lack of observable adverse effects on mammals, in particular the tremogenicity associated with the paspaline-derived IDTs is not observed (PubMed:29283570).  The geranylgeranyl diphosphate (GGPP) synthase ggs1, localized outside of the cluster, is proposed to catalyze the first step in nodulisporic acid biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (PubMed:29283570).  Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase nodC then forms 3-geranylgeranylindole (3-GGI) (PubMed:29283570).  Epoxidation by the FAD-dependent monooxygenase nodM leads to a single-epoxidized-GGI that is substrate of the terpene cyclase nodB for cyclization to yield emindole SB (PubMed:29283570).  The terminal methyl carbon, C28, of emindole SB is then oxidized by the cytochrome P450 monooxygenase nodW to produce nodulisporic acid F (NAF), the pentacyclic core of NAA (PubMed:29283570).  NAF is converted to nodulisporic acid E (NAE) via prenylation.  This step is probably performed by one of the indole diterpene prenyltransferases nodD1 or nodD2 (Probable).  Several oxidation steps performed by the FAD-linked oxidoreductase nodO and one of the cytochrome P450 monooxygenase nodR, nodX or nodZ further convert NAE to nodulisporic acid D (NAD) (Probable).  NAD is substrate of cytochrome P450 monooxygenase nodJ to produce the precursor of nodulisporic acid C (NAC), converted to NAC by one of the indole diterpene prenyltransferases nodD1 or nodD2 (Probable).  The FAD-dependent monooxygenase nodY2 then oxidizes NAC to nodulisporic acid B (NAB) (Probable).  Finally NAB is converted to NAA by one of the cytochrome P450 monooxygenases nodR, nodX or nodZ (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase nodZ, Nodulisporic acid biosynthesis cluster protein Z.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FUB10_FUSO4
Sequence: MAGDFSNRAPWKRSACDRCRAQKLRCHRDSGHSTDACLRCLKSGIECVTSKARPTGRPPSRQVQPTVSVEQGDTSSSSHTTDSSPSAGGTDINSMMNFEYDLSLDNILDSIGMQHSDFIVNDNILVDISPLSSQSTSQHSVAQAQTVDPSTIQSTTSYQFNSLPSTSSMDSALPIRSDHVELLLSRLHSKLSAQLYSIRSSPWDVKGTLNLSLAHQGIGQDFENCESHPLVQVSQACTELEKLLSGLRAPASAEHTPSSFSYTPAVPPRLRTTQLLIALSCYIQIVSIYGIIFSKVFDYLLSTSKTSIGSYQSSPLTLYIGGLPIPPNETLSGNLLVHLIEHQLHQIEQLMGLPEHYRVSSRAKDTKDGELGLFGSQHSQSLLNAAIQLGEDRDGNHDDIRCVRALKVVMRQIKDF
What is the function of this protein?
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of fusaric acid, a mycotoxin with low to moderate toxicity to animals and humans, but with high phytotoxic properties (PubMed:25372119).
What are the official names of this protein?
Fusaric acid cluster transcription factor FUB10, Fusaric acid biosynthesis protein 10.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOLD_LEUMM
Sequence: MTEILDGKAVAKTINEQTKARVAKQKRPVTLAVIYDPSNDGSQLYVGMKSRQAAKLGIVTRDIPISTDATTESVIQLVEELNDDESITGILVQSPLAKGIKERQIFSAVAPHKDADGLGATVQGMLFGDSLENYTVAATPQGVMTLLAQYNISLKGKNAVVVGRSQLFGRPMFALLTNADATVTLAHRYTEPTTLKALLKNADIVVVGVGIPNFIQGEDLKKGATVIDVGMNVVDGKATGDVNFSSAQGIAGYITPVPGGVGPMTIATLLENTVTLAEQHQ
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: SYK_MESH7
Sequence: MKIMSKLNDQQQFRRDKLKNLVKNGFNFPSSTFEHDNLVEINEKFSQKSKEFFLENQVKIAFAGRLIRQRGPFFIIFSQNLQIQAYISKKFQKKNEFIFANLDLGDIIEVSGYLFKTQTGQLSIKVNNFSLLTKSLHPLPDQYYGIENPDEKYRKRYLDLLVNSESAKTFRLRSKIISLIRTFFDSQGFLEVDTPVLHPVLGGASAKPFITYYNSLSQNFYLRIATELPLKKLLVAGFDRVYEIGKIFRNEGFDSTHNPEFTSIEFYQAYANLEKIMDQTENLFRFLFEKLNLDPANFDFSNKKINFLEKFARYDMIEITSKLMNFDLKSANFADLVEKAKKEGVKIEPFFKKGHLINKFFEKFVEPTLINPTFIIGHPIEISPLAKSNPNNPNFTLRAELFICGKEFANMFDELNDPIDQLSRFQAQIIEKNQGNQEASEIDNEFVQALEYGMPPAGGCGIGIDRLTMLLTKNESIREVILFPQLKPKKD
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_VIBVY
Sequence: MAKKVEAYIKLQVAAGMANPSPPVGPALGQRGVNIMEFCKAFNAKTESMEKGLPVPVVITVYSDRSFTFVTKTPPAAVLLKKAAGIKSGSGRPNTEKVGTVTDAQIQEIAEAKAADMTGADIEAMKRSIAGTARSMGLVVEG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: SSY5_YEAS7
Sequence: MVRFFGLNKKKNEEKENTDLPADNEQNAAETSSSNVSGNEERIDPNSHDANPENANNDDASTTFGSSIQSSSIFSRGRMTYGTGASSSMATSEMRSHSSGHSGSKNSKNLQGFKDVGKPLRAVSFLNPVKEEESQDTQNTLDVSSSTSSTLATSGNARENSFTSRRSITLEYIHKSLSELEENLVDIMDDIHQDVISISKAVIEAIEYFKEFLPTTRDRIPYRISLEKSSSLRKINKIVLHFLDNLLVSDAFSNSRSILLRRFYFFLKKLNLITDDDLISESGVLPCLSVFCIGSHCNLPSMDKLGMILDELTKMDSSIISDQEGAFIAPILRGITPKSSILTIMFGLPNLQHEHYEMIKVLYSLFPDVHMYCVKDYIKKAASAVGSIPSHTAATIDTIAPTKFQFSPPYAVSENPLELPISMSLSTETSAKITGTLGGYLFPQTGSDKKFSQFASCSFAITCAHVVLSEKQDYPNVMVPSNVLQTSYKKVLTKESDRYPDGSVEKTAFLEEVQRIDQNLNWQKSNKFGQVVWGERAIVDHRLSDFAIIKVNSSFKCQNTLGNGLKSFPDPTLRFQNLHVKRKIFKMKPGMKVFKIGASTGYTSGELNSTKLVYWADGKLQSSEFVVASPTPLFASAGDSGAWILTKLEDRLGLGLVGMLHSYDGEQRQFGLFTPIGDILERLHAVTKIQWDIDPQLDG
What is the function of this protein?
Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2.  Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs.  SSY5 binds as an inactive protease complex to STP1.  In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1 (By similarity).
What are the official names of this protein?
SPS-sensor serine protease component SSY5, Endoprotease SSY5.
What is the protein family that this protein belongs to?
Belongs to the peptidase S64 family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: CAIE_SHIDS
Sequence: MSYYAFEGLIPVVHPTAFVHPSAVLIGYVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFHGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQMEENRPRLQGTTDVTPKR
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: SPNO_SACSN
Sequence: MSSSVEAEASAAAPLGSNNTRRFVDSALSACNGMIPTTEFHCWLADRLGENSFETNRIPFDRLSKWKFDASTENLVHADGRFFTVEGLQVETNYGAAPSWHQPIINQAEVGILGILVKEIDGVLHCLMSAKMEPGNVNVLQLSPTVQATRSNYTQAHRGSVPPYVDYFLGRGRGRVLVDVLQSEQGSWFYRKRNRNMVVEVQEEVPVLPDFCWLTLGQVLALLRQDNIVNMDTRTVLSCIPFHDSATGPELAASEEPFRQAVARSLSHGIDSSSISEAVGWFEEAKARYRLRATRVPLSRVDKWYRTDTEIAHQDGKYFAVIAVSVSATNREVASWTQPMIEPREQGEIALLVKRIGGVLHGLVHARVEAGYKWTAEIAPTVQCSVANYQSTPSNDWPPFLDDVLTADPETVRYESILSEEGGRFYQAQNRYRIIEVHEDFAARPPSDFRWMTLGQLGELLRSTHFLNIQARSLVASLHSLWALGR
What is the function of this protein?
Involved in the biosynthesis of forosamine ((4-dimethylamino)-2,3,4,6-tetradeoxy-alpha-D-threo-hexopyranose), a highly deoxygenated sugar component of several bioactive natural products such as the insecticidal spinosyns A and D (PubMed:11358695, PubMed:18345667).  Catalyzes the removal of the hydroxyl group at position C-2 of the hexose ring of dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose, and the oxidation of the hydroxyl group at position C-3 to form a carbonyl functionality (PubMed:18345667).  The product of the reaction, dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose, is a highly unstable diketosugar, which spontaneously forms dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose (PubMed:18345667).
What are the official names of this protein?
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase, 2,3-dehydratase, dTDP-4-keto-6-deoxy-D-glucose 2,3-dehydratase.
What is the protein family that this protein belongs to?
Belongs to the hexose 2,3-dehydratase family.
Protein: Y3775_BACMK
Sequence: MASETVSNHQEKALALLQADAEKILRLIKVQMDNLTMPQCPLYEEVLDTQMFGLSREVDFAVRLGLIGEEQGKAMLGELERELSALHEAFTNKQQ
What are the official names of this protein?
UPF0358 protein BcerKBAB4_3775.
What is the protein family that this protein belongs to?
Belongs to the UPF0358 family.
Protein: PROP_STAAW
Sequence: MDFNKENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFSPVENADIRQMLTFAALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQIIRFYYIDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLSTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGFLVITFLHLSTAGKSLKGSYPNVDNEQDRAYYAEHPKEALWWVKERKN
What is the function of this protein?
May be a proton symporter involved in the uptake of osmolytes such as proline and glycine betaine.
What are the official names of this protein?
Putative proline/betaine transporter.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RL14_LEIXX
Sequence: MIQQESRLKVADNTGAKELLTIRVLGGSGRRYAGLGDVIVATVKDAIPGGNVKKGDVVKAVIVRTRKNTRRTDGSYIKFDENAAVILKNDGDPRGTRIFGPVGRELRDKKFMKIISLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: ADA15_RAT
Sequence: MRLALLWALGLLGAGSPRPSPPLPNIGGTEEEQQASPERTQSRSLENQVVQDSPPINLTEVLQTGLPETLRIGLELDGENHILELQQNRDLVPGRPTLVWYQPDGTRMVSEGHSLENCCYRGRVQGRPSSWVSLCACSGIRGLVVLSPERSYTLELGPGDLQRPLIVSRIQDLLLPGHTCAPSWHAFVPTEAAPDLLLEQHHLRRLKRDVVTETKIVELVIVADNSEVRKYPDFQQLLNRTLEVALLLDTFFQPLNVRVALVGLEAWTQRDLIEMSSNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQNSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDSPGNSCPCPGPAPAKSCIMEASTDFLPGLNFSNCSRWALEKALLDGMGSCLFEWPPSRAPMSSLCGNMFVDPGEQCDCGFPDECTDPCCDYFTCQLRPGAQCASDGPCCQNCKLQPAGWQCRLPTDDCDLPEFCLGDSSQCPPDIRLGDGEPCASGEAVCMHGRCASYTRQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRSPSGSYMPCNLRDAICGQLQCQWGRNQPLLGSVQDQLSEVLEANGTQLNCSWVDLDLGNDVAQPLLALPGTACGPGLVCIGHRCQPVDLLGAQECRSKCHGHGVCDSSRHCHCDEGWAPPDCMTQLRATSSLTTGLLLSLLLLLVLVLLGASYWYRARLHQRLCQLKGSSCQYRAAQSGPPERPGPPQRAQQMPGTKQANVSFPVPPSRPLPPNPVPKKLQAELADRSNPPTRPLPADPVVWRPKPQGPTKPPPPRKPLPANPQGRPPLGDLPGPGDGSLQLVVPSRPAPPPPAASSLYL
What is the function of this protein?
Active metalloproteinase with gelatinolytic and collagenolytic activity.  Plays a role in the wound healing process.  Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation.  Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells.  Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation.  Cleaves E-cadherin in response to growth factor deprivation.  Plays a role in glomerular cell migration.  Plays a role in pathological neovascularization.  May play a role in cartilage remodeling.  May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction.  May play a role in sperm-egg binding through its disintegrin domain (By similarity).
What are the official names of this protein?
Disintegrin and metalloproteinase domain-containing protein 15, ADAM 15, CRII-7, Metalloprotease RGD disintegrin protein, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, MDC-15, Metargidin.
What are the subcellular locations of this protein?
Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity).
Protein: TBB2_SOLTU
Sequence: MREILHIQGGQCGNQIGSKFWEVICDEHGVDPTGRYKGTAAESDLQLERINVYFNEASGGRYVPRAVLMDLEPGTMDSIRSGPYGQIFRPDNLVFGQSGAGNNWAKGHYTEGAELIDAVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKVREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPLPRLHFFMVGFAPLTSRGSQQYISLTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPTGLKMASTFVGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDPVAEYQQYQDATADDEEEYDDEAADDHHQYES
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta-2 chain, Beta-2-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RL27_RALSO
Sequence: MAQKKGGGSTRNGRDSESKRLGVKVYGGQAINAGGIIIRQRGTRTHAGVNVGMGKDHTLFALVDGHVKFATRGEGKKQFVDVVPAA
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: PLIN3_MOUSE
Sequence: MSSNGTDAPAEAQAAMEEPVVQPSVVDRVAGLPLISSTYGMVSAAYTSTKENYPHVRTVCDVAEKGVKTLTTAAVSTAQPILSKLEPQIATASEYAHRGLDRLQESLPILQQPTEKVLADTKELVSSTVSGAQEMVSSSVSSAKETVATRVTGAVDVTLGAVQNSVDKTKSAMTSGVQSVMGSRVGQMVISGVDRVLVKSEAWADNRLPLTEAELALIATPPEDSDMASLQQQRQEQNYFVRLGSLSERLRNHAYEHSLGKLQNARQKAQETLQQLTSVLGLMESVKQGVDQRLGEGQEKLHQMWLSWNQKTPQDAEKDPAKPEQVEARALSMFRDITQQLQSMCVALGASIQGLPSHVREQAQQARSQVNDLQATFSGIHSFQDLSAGVLAQTRERIARAREALDNTVEYVAQNTPAMWLVGPFAPGITEKTPEGK
What is the function of this protein?
Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.  Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
What are the official names of this protein?
Perilipin-3, Cargo selection protein TIP47, Mannose-6-phosphate receptor-binding protein 1.
What is the protein family that this protein belongs to?
Belongs to the perilipin family.
What are the subcellular locations of this protein?
Lipid droplet. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails.
Protein: ACPS_LIGS1
Sequence: MIYGNGIDIQEIRKIQKAQEKRESFAKRILTVNELAIFEKYKGNRKYEFLAGRFSAKEAFSKAYGTGIGKKVGFQDIEILNDNQTGRPEIVKFPGDNKLQAKISISHSGEYVVTEVILEKLTWQTKMKKFLIKQK
What is the function of this protein?
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
What are the official names of this protein?
Holo-[acyl-carrier-protein] synthase, Holo-ACP synthase, 4'-phosphopantetheinyl transferase AcpS.
What is the protein family that this protein belongs to?
Belongs to the P-Pant transferase superfamily. AcpS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADAL_BOVIN
Sequence: MMEAEEQPWKTTFYSKLPKVELHAHLNGSISSNTIRKLIAKKPDLKIHDQMTMIDKGEKRTLEECLQMFQIIHLLTTTPEDVLMVTKDVIKEFADDGVKYLELRSTPRGEDATGMTKKTYVESILEGIKQSKEENVDIDVRYLISIDRRGGSSAAKEAVKLAEEFFLSAEDTVLGLDLSGDPSAGQAKDFLEPLLEAKKSGLKLALHLSEIPNQKTETQVLLNLFPDRIGHGTFLSSSEEGSPDLVDFVRQHQIPLELCLTSNVKSQTVPAYDQHHFGFWYSVAHPAVICTDDKGVFATRLSQEYQLVAETFHLTQSQVWDLSYESISYIFASDSTKADLRKKWSHLKPHF
What is the function of this protein?
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine.  Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).
What are the official names of this protein?
Adenosine deaminase-like protein.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.