PharMolix/UniProtQA huggingface dataset:
Protein: LSPA_HELPH
Sequence: MLKTTKKSLLVFMGGFFLIFGVDQAIKYAILEGFRYESLMVDIVLVFNKGVAFSLLSFLEGGLKYLQILLILGLFIFLIRQIELFKTHAIEFGMVFGAGVSNVLDRFVHGGVVDYVYYHYGFDFAIFNFADVMIDVGVGVLLLRQFFFKQKQNKIKA
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: S2538_CANAL
Sequence: MSSPPLSSPVPQVKTTQNGKSPDATVHLLAGAIAGLVSAVTLQPFDLLKTRLQQQQLTTKQEVRTTLTKELKKLTRVKDLWRGTLPSTLRTSIGAGLYFTTLSKMRTSWGEYKQSKDSSINLKSNSSILPKLTAMENLTTGFIARGIVGYITMPITIIKTRFESNLYNYNSMYEGISGIYLDDKKQQQQIRNPSINKGVGGGGSWKNFFKGSVATLARDCPYAGLYVLTYEAFKNDLIPLIIPNSSLSLSSSSSLSSSSSLFVFNDNNRSSIINSTAAVLAASTCTTITAPFDAIKTRLQLTNEEGGSMTTVLKKMLREDGGIKNLFRGLSLRLGRKGISAGISWCIYEELIKSNYFQSKFL
What is the function of this protein?
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix.  Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
What are the official names of this protein?
Mitochondrial glycine transporter, Solute carrier family 25 member 38 homolog.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SELO_METFK
Sequence: MLTFDNRFLRELPGDPETSNQLRQVYGACWSRVMPTSVSSPKLLAYSHEMLEALELSEEEIRSPAWVDALAGNGLMPGMEPYAACYGGHQFGHWAGQLGDGRAISLGEVVNRQGQRWELQLKGAGVTPYSRMADGRAVLRSSVREFLCSEAMHHLGIPTTRALSLVQTGDVVIRDMFYDGHPQAEKGAIVCRVSPSFIRFGNFEIFAMRDDKQTLQKLVDFTIDRDFPELRNYPEEERLAEWFAIICVRTARLIAQWMRVGFVHGVMNTDNMSILGLTIDYGPYGWVDNFDPGWTPNTTDAAGRRYCFGRQPDIARWNLERLAQALYTLKPEREIYDEGLMLYDQAYNNEWGAVLAAKFGFSAWRDEYEPLLNEVFGLMTQAEIDMTEFFRKLALVDAAQPDLGILQSAAYSPALWETFKPRFSDWLGQYAQATLADGRDPAERREAMNRVNPRYVLRNYLAQQAIDLADTGDTSMIEALMDVLRKPYDEQPGKERFAALRPDWARHKAGCSMLSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: NUSB_CHLSY
Sequence: MGRARLASQRHRVRIAALQILFEVDETDHAIDQVLERRLTDEPMSQESAEFLRRLVFGAWEHRSYLDRIIEEAAPNWPVAQMPGVDKAVLRIALFELLIDDVERTPIKAVINEAVELAKQFGSDNSSRFVNGVLGTVVTRYLADRDDTVEE
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: DEOD_BACC7
Sequence: MSVHIEAKQGEIAESILLPGDPLRAKYIAETFLEDVTCYNNVRGMLGFTGTYKGKRVSVQGTGMGVPSISIYVNELIQSYGVKNLIRVGTCGAIQKDVKVRDVIIAMTACTDSNMNRLTFPGFDFAPAANFDLLKKAYDAGTEKGLHVRVGNVLTADVFYRESMDMVKKLGDYGVLAVEMETTALYTLAAKYGVNALSVLTVSDHIFTGEETTSEERQTTFNEMIEIALDAAIQQ
What is the function of this protein?
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
What are the official names of this protein?
Purine nucleoside phosphorylase DeoD-type, PNP.
What is the protein family that this protein belongs to?
Belongs to the PNP/UDP phosphorylase family.
Protein: RSMA_PSYIN
Sequence: MNDKTHLGHTARKRFGQNFLHDDYIIDSIVGAIAPQWEDNIVEIGPGLGALTEPVASKVKCLNVIELDRDLAARLAEHPVLGDKLNITQADALQFDFGKLASTERPLRVFGNLPYNISTPLMFHLFEYADKISDMHFMLQKEVVNRLCAGPNCKAYGRLTVMAQYYCRIIPVLEVPPTAFKPAPKVDSAVVRLEPYDTPPFIAKSLKCLTQVCSMAFNQRRKTIRNGLRDLLSIEQLQEIGIDTTKRAENISVEEYVNIANYVFDLKENK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IF1_DEIGD
Sequence: MPEQREKRKKEESDVVRAEGVVEEALPNTTFRVKLDSGHDILAYISGKMRIHYIRILPGDRVVLEISPYDTSRGRIVYRK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_SYNY3
Sequence: MIQQQTYLNVADNSGARKLMCLRVLGTGNCTYGGIGDQIIAVVKDALPNMPIKKSDVVRAVIVRTKQPLRRASGMSIRFDDNAAVIINAEGNPRGTRVFGPVARELRDKNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: M3H33_BOMMX
Sequence: MNFKYIVAVSFLIASAYARSVQNDEQSLSQRDVLEEESLREIRGIGGKILSGLKTALKGAAKELASTYLHRKRTAEEHEVMKRLEAVMRDLDSLDYPEEASERETRGFNQDEIANLFTKKEKRILGPVLGLVGNALGGLIKKIG
What is the function of this protein?
Maximin-H3 shows antibacterial activity against both Gram-positive and Gram-negative bacteria.  It shows also antimicrobial activity against the fungus C. albicans.  Shows strong hemolytic activity.
What are the official names of this protein?
Maximins 3/H3 type 3.
What is the protein family that this protein belongs to?
Belongs to the bombinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SYFA_STAEQ
Sequence: MTQNDLMSELKQQALVDINEANDAQALQEVKVKYLGKKGSVSALMKNMKDLPNEEKPAYGQKVNELRQTIQSELDERQKLIKEEKLNQQLSEETIDVTLPSRHIEIGSKHPLTRTVEEIEDLFLGLGYEIVDGYEVEQDYYNFEALNLPKSHPARDMQDSFYITEEILMRTHTSPVQARTMEKRKGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNIKMSDLKGTLELVAKKLFGADREIRLRPSYFPFTEPSVEVDVSCFKCKGQGCNVCKHTGWIEILGAGMVHPNVLEMAGFDSKEYSGFAFGMGPDRIAMLKYGIEDIRHFYTNDVRFLDQFKAVEDRGEQ
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSRA_HALH5
Sequence: MEKRLERAMFAGGCFWCMVQPFDKQPGIESVVSGYAGGTVENPTYEQVKTGTTGHYEVVHITYVPELFPFEKLLSLYWPQIDPTDPDGQFHDRGPQYRTAIFYENEEQRALAERSREALEKSGKFKKPIVTSILPMATFYPAEEEHQQFYKKNPMAYKEDREKSGRDEFIYKHWGK
What is the function of this protein?
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation.  Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
What are the official names of this protein?
Peptide methionine sulfoxide reductase MsrA, Protein-methionine-S-oxide reductase, Peptide-methionine (S)-S-oxide reductase, Peptide Met(O) reductase.
What is the protein family that this protein belongs to?
Belongs to the MsrA Met sulfoxide reductase family.
Protein: CRCB1_STRAW
Sequence: MNWLLVIAGAMVGAPLRYVTDRMVQLRHDAVFPWGTFAINVTGCLVLGLLTGAASAGVASPHLELLLGTGLCGALTTYSTFSYETLRLTETGAGFYAAANAIASVAAGLGAAFAGVWFAQALWA
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB 1.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y118_TREPA
Sequence: MFADKSLSALNAACQRAQQDLQSHCCSLGEHIVRGGAACDISGLGVQDTDISRCHALQRQRDQVAESILDIKSILQRQEELAALGKRVSKVLHRHARQERDVLRSFVAQYYATYAHVGLPALEPIYARTAELESTLQDLRAKRDQLLETCTFGSILERVGLQAKSAVVQRRIRVLEAKIQKIITLCTPDVIAHPDVERMYHAGELSSALSAAYARLISDRGVYASNLQHSQELMDEQEALDARLRALDCGAKPLKRVAAFTAQVSELDEDINALCARIGAAYASCFFTEEGFAQPPLSQKTRPTVPDELSTLLRTVAEARMRVARAGYQVECAKLRQKLQSEQRVCESFCRSIEEYRRGIKEYEAMIESAQQNVALSKATVARLAQSLEEASERLTLFETSPEPIVLSSEVLSVPQEKASV
What are the official names of this protein?
Uncharacterized protein TP_0118.
Protein: RHEB_CROSI
Sequence: SSLTIQFVEGQFVDSYDPTIENTFTK
What is the function of this protein?
Activates protein kinase activity.
What are the official names of this protein?
GTP-binding protein Rheb homolog, Peptide 1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rheb family.
Protein: ATPL_GLOC7
Sequence: MDPMLASASVIAAALAVGLAAIGPGIGQGNASGQAVSGIARQPEAEGKIRGTLLLTLAFMESLTIYGLVISLVLLFANPFA
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: PPE25_MYCTU
Sequence: MDFGALPPEINSGRMYCGPGSGPMLAAAAAWDGVAVELGLAATGYASVIAELTGAPWVGAASLSMVAAATPYVAWLSQAAARAEQAGMQAAAAAAAYEAAFVMTVPPPVITANRVLVMTLIATNFFGQNSAAIAVAEAQYAEMWAQDAVAMYGYAAASASASRLIPFAAPPKTTNSAGVVAQVAAVAAMPGLLQRLSSAASVSWSNPNDWWLVRLLGSITPTERTTIVRLLGQSYFATGMAQFFASIAQQLTFGPGGTTAGSGGAWYPTPQFAGLGASRAVSASLARANKIGALSVPPSWVKTTALTESPVAHAVSANPTVGSSHGPHGLLRGLPLGSRITRRSGAFAHRYGFRHSVVARPPSAG
What are the official names of this protein?
Uncharacterized PPE family protein PPE25.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
Protein: PRP17_HUMAN
Sequence: MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD
What is the function of this protein?
Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:33220177).  Plays an important role in embryonic brain development; this function does not require proline isomerization (PubMed:33220177).
What are the official names of this protein?
Pre-mRNA-processing factor 17, Cell division cycle 40 homolog, EH-binding protein 3, Ehb3, PRP17 homolog, hPRP17.
Protein: NUOD_LEGPA
Sequence: MIELKNYTLNFGPQHPAAHGVLRLVLELEGETIVRADPHIGLLHRATEKLAETKPYIQSIGYMDRLDYVSMMCNEHAYVMAIEKLLGIEPPLRAKYIRTMFDEVTRILNHLLWLGATALDIGAMTVFLYCFREREDLFDCYEAVSGARMHATYYRPGGVARDLPDTMPQYKPSRWHNEREIEKKNHNRQGSLLDFLWAFTERFPRCVDEYETLLTDNRIWKQRTVDIGIVSPENALQWGFTGPMLRGSGIAWDLRKKQSYAAYDRVDFDIPVGKTGDCYDRYLVRVEELRQSNRIIRQCIEWLRKHPGPVKVDDYKVTPPRRVVMKHDMEALIHHFKLFTEGFCLPRGEVYSSVEAPKGEFGIYMVSDGANKPYRLKIRAPGFAHLSSFDDMVRGHMLADGVAILASQDIVFGEIDR
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit D, NADH dehydrogenase I subunit D, NDH-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the complex I 49 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: ACCD_BACCZ
Sequence: MLRDLFVKKKKYAAIPSEQVRKDVPDGVMTKCPKCKKIMYTKEVLKNLKVCVNCGYHHPMNAWERLDSILDEGSFREYDKEMVSLNPLEFPDYEEKLESDRKKTDLNEAVVTGEGTIDDMLVVVAVMDSRFRMGSMGSVVGEKIARAVEKAYDLQVPFIIFTASGGARMQEGILSLMQMAKTSVALKKHSNAGGLFISVMTHPTTGGVSASFASLGDYNLAEPGALIGFAGRRVIEQTVREKLPEDFQTAEFLLEHGQLDAVVHRDDMRESLRKILEVHQGGEMAVWQS
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PUR7_YEAST
Sequence: MSITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSKWSH
What is the function of this protein?
Catalyzes the reaction of 4-carboxy-5-aminoimidazole ribotide (CAIR) and aspartic acid with the formation of N-succinyl-5-amino-imidazole-4-carboxamide ribotide (SAICAR) in the purine biosynthesis pathway.
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: ITM2C_RAT
Sequence: MVKISFQPAVAGVKAEKADKAAASGPASASAPAAEILLTPAREERPPRHRSRKGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVLYEDSLSSQIRTRLELEEDVKIYLEENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVRDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV
What is the function of this protein?
Negative regulator of amyloid-beta peptide production.  May inhibit the processing of APP by blocking its access to alpha- and beta-secretase.  Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.  May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
What are the official names of this protein?
Integral membrane protein 2C.
What is the protein family that this protein belongs to?
Belongs to the ITM2 family.
What are the subcellular locations of this protein?
Lysosome membrane; Single-pass type II membrane protein. Cell membrane; Single- pass type II membrane protein.
Protein: APF7_GIBF5
Sequence: MILFSVSPVSIWVFVIYAVTIIIAIYRLFFHPYAKYPGPFLAKLTSWYSIYHTYYGDLHIDIWECHNKYELGNYVRYGPNRILVNTSEGLNAIYSQGKNTQKAKAYRKVSLVPGVHPTFSMIDNQGHAKLRRLVGQGLSNAHIRMYDQELRQSALLFASRLGEEIDRFEPNQPHGNHDGWTSPKNVASWSNYFTFDVMSHLVYGTSYDLLTDSENHWVIEGVLGQMRRISFLTMLPELEDMRFDRILFPDARRKAYRFSAKSREILEARKSKSEEMRHQDAKVDVFLRLLSAKDPETGESLSDKQLWAESNLLIIAGSDTSSTGLAASFFYLSRNPSAYDRVKQEVRSALTTSEDISQGPKLLSCTYLRACVLESLRLSPPLGGAMWRQTMPGGLFIAGSDHDFHIPGGCEVGTGVYAIHHNEEYYPEPFRFRPERWLPQEVGDEAVAKAQSAFQAFSLGPRSCPGKNLAMLEIPFALAAVMMDYDFRKVDSPLGGVGEGKGKFVGQYQTFWAFTSIKDGPYIQFKRREP
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF) (PubMed:25058475).  The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L-phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L-2-aminooctanedioic acid (PubMed:25058475).  L-Phenylalanine is the only proteinogenic amino acid directly used by apf1 (PubMed:24195442, PubMed:25058475).  The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster (PubMed:25058475).  Lysine is converted to delta-1-pyrroline-5-carboxylate (P5C) which is reduced to L-pipecolic acid (L-pip) by apf3 (PubMed:25058475).  L-pip is epimerized to D-pip, probably by apf1 activity, prior to incorporation (PubMed:25058475).  L-Tryptophan is N-oxidyzed by one of the cytochrome P450 monooxygenases (apf7 or apf8), and further methylated at the hydroxy group by the O-methyltransferase apf6 to yield N-methoxy-L-tryptophan (PubMed:25058475).  The synthesis of the fourth apf1 substrate is more complex (PubMed:25058475).  The fatty acid synthase apf5 is involved in the synthesis of the octanoic acid backbone of L-2-aminooctanedioic acid by fixing one acetyl-CoA unit and three malonyl-CoA units (PubMed:25058475).  Then one of the cytochrome P450 monooxygenases (apf7 or apf8) may oxidize this backbone to 2-oxooctanoic acid (PubMed:25058475).  The aminotransferase apf4 is predicted to catalyze the exchange of the keto group with an amino group (PubMed:25058475).  The next step would be the oxidation of 2-aminooctanoic acid by one of the cytochrome P450 monooxygenases (apf7 or apf8).  The last step is the oxidation of 2-amino-8-hydroxyoctanoic acid to 2-aminooctanedioic acid is catalyzed by the FAD-dependent monooxygenase apf9 (PubMed:25058475).
What are the official names of this protein?
Cytochrome P450 monooxygenase apf7, Apicidin F synthesis protein 7.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: GRPE_STAA1
Sequence: MTNKDESVEKNTESTVEETNIKQNIDDSVEQAEESKGHLQDEAIEETSDENVIEEIDPKDQKINELQQLADENEEKYLRLYAEFENYKRRIQKENEINKTYQAQRVLTDILPAIDNIERALQIEGDDETFKSLQKGVQMVHESLINALKDNGLEVIKTEGEAFDPNIHQAVVQDDNPDFESGEITQELQKGYKLKDRVLRPSMVKVNQ
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ADD_MYCTU
Sequence: MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPATDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQTPEALYRVAFECAQDLAADSVVYAEVRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSREIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDIDVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAFGYGWSDLARFTVNAMKSAFIPFDQRLAIIDEVIKPRFAALMGHSE
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: MARE1_PONAB
Sequence: MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLSSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGDDEAAELMQQVNVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY
What is the function of this protein?
Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton.  Promotes cytoplasmic microtubule nucleation and elongation.  Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation.  Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement.  Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules.  Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity).  May play a role in cell migration (By similarity).
What are the official names of this protein?
Microtubule-associated protein RP/EB family member 1, APC-binding protein EB1, End-binding protein 1, EB1.
What is the protein family that this protein belongs to?
Belongs to the MAPRE family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the microtubule growing distal tips. Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE.
Protein: RL27_BDEBA
Sequence: MASKKAGGSTKNGRDSQSKRLGVKRFGGEKVLPGTIIVRQRGTKFHLGNNVKMGRDYTIYSVVEGLVKFERFSKERFKVSVYPKAV
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: CALM1_BRALA
Sequence: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTSK
What is the function of this protein?
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).  Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
What are the official names of this protein?
Calmodulin-1, CaM 1.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: YBEY_SERP5
Sequence: MSQVILDLQLACADNSGLPDEATFQRWLEGVLPQFQEEAEVTIRLVDEAESNELNLTYRGMDKPTNVLSFPFEAPPGIELPLLGDLIICRQVVEREAAEQDKALEAHWAHMVVHGSLHLLGYDHIEDDEAEEMESLETEIMHGLGYPDPYLAEKDPL
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.