PharMolix/UniProtQA huggingface dataset:
Protein: E2F7_RAT
Sequence: MEVNCLTLKDLISPRQTRLDFAVEDAETAQKENIFVDRSRMTPKTPMKNEPIDLSKQRIFTPERSPITPVKLVDRQPQVEPWTPTANLKMLISAASPDIRDREKKKELFRPIENKGDAFVNSLQLDVVGDSAVDDYEKRRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRTLQRLGEEQKYEEQMACLQQKELDLMEYRFGERRKDGSPDPRDQHLLDFSESDYPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDTPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSIDEELLDVSASVLPELKKETYGQIRVCAKERLARYGSFNTVQTSEKIQRKVNSEPSSPQGGKQGPAYSLEIGSLAAIYRQKVEDSSQGEAFVNKRAAPPASVLDPTLPVDSEYCVKPLAQPVFSVAQTDLQAFSAQNGLNGQVGVPVPSAASDAETLKSALLASQPLVYVPSTSLFMLYGSVQEALSPESRSEEDGSGSDVPADLSLAPTAQKRLCEERNPLEDDEPAVKRQSREFEDSPLSLVMPKKPSNSTDLAFPVTTGNGRATPLEDACVKGQLPAAEDASGRAVPNGFIASECGNPSRNPDTEKSSNDNEITKDPSLLQYLYVQSPAGLNGFNMLLPGGQTPHAVAPSSAAMPSFGVPCMFLPSPGLGPFPVLYSPAIPGPISSAPGTLPNTGPMNFGLSTLASASHLLISPAAMVNPKSSTLPSADPQLRCQPPLNPNPVMPGSHGVIHPESPGYMRHPVSMVKAEQSPAPATPKSIQRRHRETFFKTPGSLGDPAFRRERNQSRNTSSAQRRLEISSSGPD
What is the function of this protein?
Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response.  Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'.  Directly represses transcription of classical E2F transcription factors such as E2F1.  Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes.  Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3).  Required for placental development by promoting polyploidization of trophoblast giant cells.  Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication.  Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.  Acts as a negative regulator of keratinocyte differentiation (By similarity).
What are the official names of this protein?
Transcription factor E2F7, E2F-7.
What is the protein family that this protein belongs to?
Belongs to the E2F/DP family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSAE_SYNS9
Sequence: MAISRGAKVRIKRPESYWFNEVGTVATIDTSGIRYPVVVRFEKVNYSGMQGVDGGINTNNFAESELESA
What is the function of this protein?
Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase.
What are the official names of this protein?
Photosystem I reaction center subunit IV.
What is the protein family that this protein belongs to?
Belongs to the PsaE family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: DYIN_DROME
Sequence: MDRKAELERKKAKLAALREEKDRRRREKEIKDMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVAPVSEVLSSLSSVNSMTSDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSDEV
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.  The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).
What are the official names of this protein?
Cytoplasmic dynein 1 intermediate chain, DH IC, Dynein intermediate chain, cytosolic, Protein short wing.
What is the protein family that this protein belongs to?
Belongs to the dynein intermediate chain family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. SUBCELLULAR LOCATION: [Isoform 2c]: Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around lysosomes. SUBCELLULAR LOCATION: [Isoform 2a]: Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around the nucleus. SUBCELLULAR LOCATION: [Isoform 2b]: Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around the nucleus.
Protein: LEUD_SYNAS
Sequence: MKFTGKVWKFGDNIDTDAIIPARYLNTFDPQALAAHCMEDADPDFPKKVSAGDIIVAGENFGCGSSREHAPIAIKAAGVSCVIAKSFARIFYRNAFNMGLPIFESAELFDRVDEGQTITVDGDSGVILLEGAQTPLSIQPIPPFMQELIADGGLMKHLARKNRG
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 2 subfamily.
Protein: PKG20_BPPRD
Sequence: MVNWELLKNPINWLIVILMLTIAGMAATLVCNHFGKNAVTSE
What is the function of this protein?
Together with P22, forms the internal part of the portal complex embeded in the virion internal membrane and which plays critical roles in genome packaging and genome ejection.  Both proteins multimerize as a single ring-shaped heterdodecamer arranged around a central channel and interact with the P6/P9 external part of the portal.
What are the official names of this protein?
Packaging protein P20.
What are the subcellular locations of this protein?
Virion membrane; Single-pass membrane protein. Note=Part of the capsid inner membrane. Binds the portal complex at the capsid vertex.
Protein: MED21_ANOGA
Sequence: MADRLTQLQDTVNQQAEHFCNSIGILQQCSVPSKFAGFERTGSQTPQQQVHQQQQLPQQQQQQQQPQQQEDFPQLFSTLISRCAKDIDTLIESLPSEESSIELQVQSLQRLEAENKESAEKLEEIVRKGELLLEKIQAALSDIAQSQLDMQYSS
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
What are the official names of this protein?
Mediator of RNA polymerase II transcription subunit 21, Mediator complex subunit 21.
What is the protein family that this protein belongs to?
Belongs to the Mediator complex subunit 21 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SNF12_YEAST
Sequence: MSKVMKPSNGKGSRKSSKAATPDTKNFFHAKKKDPVNQDKANNASQITPTVPHSHPSDMVIPDHLAELIPELYSFQQLVDSEKRLDHFIHLRNLHMKRMVAQWERSKLSQEFLYPHLNFPNVKFLRIFISNVSENQPWQMDTNNEADLMALENATWTMRIEGRLLDNVQANDPAREKFSSFIESIVVDFKNKENDNVPSTKFNAAPEENATEGPSDKKLNLNLPLQFSLPNGDNSTTTNTDQNNATMGEETAKKDMSSTTPKLESVKWQYDPNNPVDFDGLDIKRVGSENVECTISILRKSSPEEPFMSYSPQLTAIIGLKSGTSHDAIFSIYKYIHLNELLTNDESAFENLMGNRNNHNSNTSTSKMLDAASSQVSIVKLDTQLITLLPSSLKESSPDTMKLTDLLSLINSTHLLPLQPIEIDYTVRVDKASTYGELVLDIEVPDVNALKFNNTQRESQIGAAELNENARELEQIKPKIALQDKEITSVLSNLHESNKRYRFFKKISEDPVKALNECIASTSNALKVLSGDEGYNEDMVRRANFYKENEAMLRENIEVILSNGRM
What is the function of this protein?
Involved in transcriptional activation.  Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes.  It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
What are the official names of this protein?
Transcription regulatory protein SNF12, SWI/SNF complex component SWP73.
What is the protein family that this protein belongs to?
To yeast RSC6.
What are the subcellular locations of this protein?
Nucleus.
Protein: FA76A_HUMAN
Sequence: MAALYACTKCHQRFPFEALSQGQQLCKECRIAHPVVKCTYCRTEYQQESKTNTICKKCAQNVQLYGTPKPCQYCNIIAAFIGNKCQRCTNSEKKYGPPYSCEQCKQQCAFDRKDDRKKVDGKLLCWLCTLSYKRVLQKTKEQRKHLSSSSRAGHQEKEQYSRLSGGGHYNSQKTLSTSSIQNEIPKKKSKFESITTNGDSFSPDLALDSPGTDHFVIIAQLKEEVATLKKMLHQKDQMILEKEKKITELKADFQYQESQMRAKMNQMEKTHKEVTEQLQAKNRELLKQAAALSKSKKSEKSGAITSP
What are the official names of this protein?
Protein FAM76A.
What is the protein family that this protein belongs to?
Belongs to the FAM76 family.
Protein: AT2B1_PIG
Sequence: MGDMANNSVAYGGVKNSLKEANHDGDFGITLADVRALMELRSTDALRKIQESYGDVYGICTRLKTSPVEGLSGNPADIERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKIPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNCSPPPSPNKNNNAVDSGIYLTIEMNKSATSSSPGSPLHSLETSL
What is the function of this protein?
Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis.  Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction.  Positively regulates bone mineralization through absorption of calcium from the intestine.  Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity).  Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (By similarity).  May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
What are the official names of this protein?
Plasma membrane calcium-transporting ATPase 1, Plasma membrane calcium ATPase isoform 1, PMCA1, Plasma membrane calcium pump isoform 1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Synapse. Presynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Colocalizes with SV2A in photoreceptor synaptic terminals. Colocalizes with NPTN to the immunological synapse. Colocalizes with EPB41 to the basolateral membrane in enterocyte. Preferentially sorted to recycling synaptic vesicles.
Protein: TPS5_SOLLC
Sequence: MVSILSNIGMMVVTFKRPSLFTSLRRRSANNIIITKHSHPISTTRRSGNYKPTMWDFQFIQSLHNPYEGDKYMKRLNKLKKEVKKMMMTVEGSHDEELEKLELIDNLERLGVSYHFKDEIMQIMRSINININIAPPDSLYTTALKFRLLRQHGFHISQDILNDFKDENGNLKQSICKDTKDILNSSKDEHDNLKQSTCNNTKGLLKLYEASFLSIENESFLRNTTKSTLAHLMRYVDQNRCGEEDNMIVELVVHALELPRHWMVPRLETRWYISIYERMSNANPLLLELAKLDFNIVQATHQQDLRILSRWWKNTGLAEKLPFSRDILVENMFWAVGALFEPQHSYFRRLITKVIVFISIIDDIYDVYGTLDELELFTLAIQRWDTKAMEQLPDYMKVCYLALINIINEVAYEVLKNHDINVLPYLTKSWADLCKSYLQEAKWYHNGYKPNLEEYMDNARISIGVPMVLVHSLFLVTNQITKEALDSLTNYPDIIRWSATIFRLNDDLGTSSDELKRGDVSKSIQCYMNEKGASEEEAIEHIEFLIQETWEAMNTAQSKNSPLSETFIEVAKNITKASHFMYLHSDVKSSISKILFEPIIISNVAFALK
What is the function of this protein?
Involved in monoterpene (C10) biosynthesis in glandular trichomes (PubMed:17440821).  Converts geranyl diphosphate to linalool in glandular trichomes in response to jasmonate (JA) (PubMed:17440821).  Can convert farnesyl diphosphate to nerolidol in vitro (PubMed:17440821).
What are the official names of this protein?
(R)-linalool synthase TPS5, chloroplastic, Monoterpene synthase 1, LeMTS1, Terpenoid synthase 5.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family. Tpsb subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PCDG4_HUMAN
Sequence: MHFILDPEDPGAPQASTEGKPKHRRLRGGVVMAAPPARPDHTRLLQICLLLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLGLAPRELAERGVRIVSRGRTQLFALNPRSGTLVTAGRIDREELCDRSPNCVTNLEILLEDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAFDPDVGVNSLQGYQLNSNGYFSLDVQSGADGIKYPELVLERALDREEEAVHHLVLTAFDGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVRENVPVGTRLLTVKATDPDEGANGDVTYSFRKVRDKISQLFQLNSLSGDITILGGLDYEDSGFYDIDVEAHDGPGLRARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPDNLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFPHASYSAYIPENNPRGASILSMTAQDPDSGDNARITYSLAEDTFQGAPLSSYVSINSNTGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTGVELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRDALKQRLVVVVQDHGQPPLSATVTLTVAVADSIPDVLADLGSLKPSADPDDSGLTLYLVVAVAAVSCVFLAFVTVLLALKLRRWHKSRLLHAEGSRLAGVPASHFVGVDGVRAFLQTYSHEVSLTADSRKSHLIFSQPSYADTLISRESCEKSEPLLITQDLLETKGDPNLQQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
What is the function of this protein?
Potential calcium-dependent cell-adhesion protein.  May be involved in the establishment and maintenance of specific neuronal connections in the brain.
What are the official names of this protein?
Protocadherin gamma-A4, PCDH-gamma-A4.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: EFGM_CAEEL
Sequence: MSPLGRFSAVAQSRRQLNNVLRRFASNEAPSSVVVPGVRPIERIRNIGISAHIDSGKTTVTERILYYAGRIDSMHEVRGKDDVGATMDFMDLERQRGITIQSAATYVDWHGTNINIIDTPGHVDFTVEVERALRVLDGAVLVLCGVGGVQSQTFTVNRQLARYNVPFICFVNKMDRNGATPLKALDGLRNKLNHNAALIHLPIGKDSNFNGIVDLVEGHALYYEGEGGLIVRKDEIPKDLRVEAEDRRQELIEHIANVDETLGEMFLNDQTPNVQQIHEAIRRTVVKRAFVPVLSGSALKNKGVQTMINSVVKYLPDPSEVVNRATVKTETTGDEKGIILSPKRNNDKPFVGLAFKLEAGKYGQLTYFRVYQGQLSKGDTVYASRDGRKVRVQRLVRMHAADMEEITTAYAGDICATFGLDCHSGETFSTDQNLAPHCESMHIPEPVISMAIKPVNRKDADNFIKALTRFTKEDPTFRREYNQEAKETIVSGMGELHLEIYAQRMKSEYNCPVELGKPTVAYRECLGSPYKFHFRHKKQTGGQGQFGEIEGVIDPLPSDRNTVVEFSDETFGNNIPKNLFPALKKGLDAIVAEGPLIKSRIAGIHVRIQDGSTHAVDSTEIAMINTMQNMMRESFEKANWLLLEPIMKVEATVPTEFQGNVVTSLTQRNALITTTDSTEGYATVICEAPLSDMFGYTSELRSLTEGKGEFSMEYSRYAPTTLEAQDRVQAEWRQLHGIADPNEKGKKKKK
What is the function of this protein?
Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, mitochondrial, EF-Gmt, Elongation factor G 1, mitochondrial, mEF-G 1, Elongation factor G1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: METK_BACAA
Sequence: MTKKRHLFTSESVTEGHPDKICDQISDSILDAILSKDANARVACETTVTTGLVLVAGEITTSTYVDIPKIVRETIQGIGYTRAKYGFDAETCAVLTSIDEQSADIAMGVDQALEAREGQMTDAEIEAIGAGDQGLMFGFACNETQELMPLPISLAHKLARRLTEVRKNDTLSYLRPDGKTQVTVEYDENGKPVRVDTIVISTQHHPDVTWEEIDRDLKEHVIKAVVPAELIDGETKFFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGAFSGKDATKVDRSAAYAARYVAKNIVAAGLAEKAEVQLAYAIGVAQPVSISVDTFGTGKVSEDVLVELVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRTDVDLSWERTDKAAALKEQAGL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDTA_CAMJE
Sequence: MQKIIVFILCCFMTFFLYACSSKFENVNPLGRSFGEFEDTDPLKLGLEPTFPTNQEIPSLISGADLVPITPITPPLTRTSNSANNNAANGINPRFKDEAFNDVLIFENRPAVSDFLTILGPSGAALTVWALAQGNWIWGYTLIDSKGFGDARVWQLLLYPNDFAMIKNAKTNTCLNAYGNGIVHYPCDASNHAQMWKLIPMSNTAVQIKNLGNGKCIQAPITNLYGDFHKVFKIFTVECAKKDNFDQQWFLTTPPFTAKPLYRQGEVR
What is the function of this protein?
CDTs are cytotoxins which induce cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells.
What are the official names of this protein?
Cytolethal distending toxin subunit A, CDT A.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: HIS1_PSYIN
Sequence: MPEQRLRIAIQKKGRLSEDTVKLLKACGVKVNLNTQRLIAHSDNMAIDILRVRDDDIPGLIMDGVVDLGFIGQNVLEEENMMRTVAKEPTAHKVVKELAFGACRFSIAVDQDFDYQGAKSLANLRIATTYVHILKRFMEEQNIPYTSCMLTGSVEVAPRAGLADAICDLVSTGATLEANGLKEVEVIYRSTAVLIQRADPLNQQKQDLVNRLLTRIDGVQSAKECKYIMLHAPTANLEAIKSLLPGSEQPTVMQLSGSSDHVALHVVSKENLFWETMEQLKTLGASSILVLPIEKMME
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DCOR_SOLLC
Sequence: MAGQTVIVSGLNPAAILQSTIGGAPVAAAAENGHTRKVVPLSKDALQDFMVSIITQKLQDDKQPFYVLDLGEVVSLMEQWNSALPNIRPFYAVKCNPEPSFLSMLSAMGSNFDCASRAEIEYVLSHGISPDRIVFANPCKPESDIIFAEKIGVNLTTYDSEDEVYKIRKHHPKCELLLRIKPMTDGNARCPMGPKYGALPEEIEPLLRTAQAARLTVSGVSFHIGSGDADSNAYLGAIAAAKQVFETAAQLGMPKMTVLDIGGGFTSGHQFTTAAPAVKSALETHFHDFPELTIIAEPGRFFAETAFTLATTIIGKRVRGELKEYWINDGLYGSMNCVLYDHATVTATPLACMSNRNNLNCGGSKTFPSTVFGPTCDALDTVLRDYQLPELQVNDWLIFPNMGAYTKAAGSNFNGFNTSAIVTHLAYAYPN
What is the function of this protein?
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine.  Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
What are the official names of this protein?
Ornithine decarboxylase, ODC, LeODC.
What is the protein family that this protein belongs to?
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Protein: NU5M_STRPU
Sequence: MVISPSLIISSLNLGILTILLGSIFFFSKSYFSKGNVNFPLIKTTSACLSVNNDKEETIEYNSGPFAMAILKVLAFLSVLSLLVTCNNSIQSINITLSLWLSNTPLNISLNFIYDQYFLVFLSVALIVTWSIMEFSFYYMTEDPNSSAFFRLLTIFLLNMLILTCSNSLFLIFLGWEGGGFLSFLLISWWTTRNDASSSALEAVITNRIGNIGLITFMALSALNFNSSNLTNILSSNENLTPLLPFLLFGLILAAAGKSAQFGLHPWLPALLEGPTPVSALLHSSTMVVAGVFLLVRTSELFSSPLITHSLVLILGGTTALFAASTAIAQHDIKKIIAYSTTSQLGLMVTAIGIGQPALAFFHICTHAFFKAMLFLCSGSVIHSLSDEQDLRKMGGLSKLLPVTSSCLILGSLALMAPLLAGFYSKDLILEATSASVLNLLGIVLSIVATMLTAVYSFRIIFFCFSLSPSCSSPFSHSEENFNLNNALLRLATGTIASGWFFSNLLFAPPSFNVTSLAKGTPLIVPIIGVAALFMSLISSTSNSIGSNAHSATTSQWFFVDAVHLSIITMSLALSFFSSRTLDRGWQENIGPQGIAPTSTALSKISQAGQIGLIKRYILSSMASVLVILALSLLILS
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 5, NADH dehydrogenase subunit 5.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 5 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: YEHE_ECOLI
Sequence: MNKYWLSGIIFLAYGLASPAFSSETATLAINGRISPPTCSMAMVNGQPQQHCGQLTYNVDTRHLFSSPVKGVTTEVVVAGSDSKRRIVLNRYD
What are the official names of this protein?
Uncharacterized protein YehE.
Protein: RL9_MYCA1
Sequence: MKLILTADVDHLGAVGDTVEVKDGYGRNFLLPRGLAIVASRGAQKQADDIRRARETKAVRDLDHANELKTAIEALGPVTLPVKTAGDSGKLFGSVTAGDVVAAIKKAGGPNLDKRIVRLPKAHIKALGTHPVAVHLHPEVDVEVALEVVPQS
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: EFG1P_COCIM
Sequence: MSLHEPEAQPSLKKRRRDSFSNADPKRVKRLHSGTQRLHYHDIGPSVNELKTRIRDVKRLLAKRIDDLPADVRVAKERELAECQRDLEKAEVKKQRSKMIQKYHFVRFLERKRATKELKRLKGQLHKLENDDRLDPNARENSIETLNRKISASEIDLNYTIYSPLTEKYISLYPNERRKQQPMEPEESNVIRTNSGEKPPLWYTVKQSMADGTLELLRDGKLGIGLSGEKKDSNNADVSLKSNTMSLLVHRKQKKPKSKIKVDGDEDAKRSSARSVQEGTRNENKRTSKEDVQGEDDDAESESDGGFFE
What is the function of this protein?
Involved in rRNA processing.
What are the official names of this protein?
rRNA-processing protein EFG1.
What is the protein family that this protein belongs to?
Belongs to the EFG1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RL34_WOLTR
Sequence: MKRTFQPKNLIRKRRHGFRSRMATRAGRKILNRRRSLGCKKLCA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: GSA1_BACC4
Sequence: MNFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVIYDEVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQEGLYEKLDELGAMLEKGILEQAAKHNIDITLNRLKGALTVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGVNLAPSKYEAWFLTTEHTKEDIEYTIEAVGRAFAALADNK
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 1, GSA 1, Glutamate-1-semialdehyde aminotransferase 1, GSA-AT 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.