PharMolix/UniProtQA huggingface dataset:
Protein: PYRG_SULAC
Sequence: MTKYIIVTGGVLSSVGKGTIVASIGFLLKSSGYNVTAIKVDPYLNVDAGTMNPYMHGEVFVTDDGAETDLDLGHYERFIGINTTRYNNITAGRVYFEVIRKEREGKYLGQTVQIIPHVTDEIKGLVKKAVDDTNAEIAIIEIGGTVGDIEGLPFLEAVRQMKLEEEENLMFIHVALVEYLRVTGELKTKPLQHSVQELRRIGIQPDMIIARSILPLDEETKKKIALFTNVKPDYILSNYDVELTYEVPLILEKQNITKKIFNKLGLEPKEPKVAEWLEFVENMKNPSKEVKIALVGKYTKLKDSYLSIKEAIYHAAAKLRVKPTLVWVESSDLEKSEDEINKLKDVNGIIVLPGFGARGVEGKIQAIKFARENNIPFLGICFGMQLAIVEYARNVLGLKEANTTEVNPNTKYPIITLLDNQKKIVQVGGTMRLGAQKIILKEGTLAYSIYNSPHIYERHRHRYEVNPEYVDLLQKYGMIISGVSENGLVEIIELKNHKFFLGTQAHPEYKSRPLSPSPVFLNFLSVASA
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: OTC_PROM9
Sequence: MVKPNKLANNNYLSSFDMTTDEFINILDLAKNFKNKKINIDPNNKVLGLIFDKSSTRTRVSFQVAMSRLGGTTIDLNPITSQIGRGEPIKDTARVLSRYCDVIAIRTFNHSDLEEYAKWSTIPVINALTDLEHPCQALADFLTIQEEFIDFRNVVLTFIGDGNNVANSLILCGALLGVEVRIACPRGYEPNVSVINKALEIYKNKNLLKIIHDPYDAVLGANVLYTDVWSSMGEENQKEDKDKDFKGFTINSSLVRKANKDAIILHCLPAYRGKEISAEVFESKISRIFKQAENRLHVQQALLAGLLS
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAA2_BACFR
Sequence: MTMPDYDLIAILGPTASGKTPFAAALAAELNTEIISADSRQIYRGMDLGTGKDLEDYTINGRQIPYHLIDIADPGYKYNVFEYQRDFLTAYETIKQKGCLPVLCGGTGLYLESVLKGYRLIPVPENQELRVRLAEKSLEELTAILSSYKTLHNSTDVDTVKRAIRAIEIEEYYAKTPIEEREFPQLNSLIIGVDIDRELRREKITRRLKQRLDDGMVEEVRRLLAEGIQPDDLIYYGLEYKYLTLYAIGKMTYDEMFTGLETAIHQFAKRQMTWFRGMERRGFTIHWVDASLPMEEKINFVKQKLKEF
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase 2, Dimethylallyl diphosphate:tRNA dimethylallyltransferase 2, DMAPP:tRNA dimethylallyltransferase 2, DMATase 2, Isopentenyl-diphosphate:tRNA isopentenyltransferase 2, IPP transferase 2, IPPT 2, IPTase 2.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: OVOL3_MOUSE
Sequence: MPRVFLVRSRRPQPPNWSHLPDQLRGDAYVPDCSSLAVPPAHRSSGLRDTWAVSSQGTLTSAPKGPGTLGCPLCPKAFPLQRMLTRHLKCHSPARRHVCHYCGKGFHDAFDLKRHMRTHTGIRPFRCGACGKAFTQRCSLEAHLAKVHGQPASYAYRERREKLHVCEDCGFTSSRPDAYAQHRTLHRTT
What is the function of this protein?
May act as a transcription regulator.
What are the official names of this protein?
Putative transcription factor ovo-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FAD3_RHOJR
Sequence: MTEQPTTTPSALKRAAREFGELTAVADGDVRLTFTQLHDRVRDFAAALSSQDVRPGDHVAVWSPNTYHWVVAALGIHYAGATLVPINTRYTATEALDILERTKTTALVVAGNFLGTDRYASLRDESSTFDLPTVVRVPVDGGDAELPGVFDFDDFLALADEDTRAEADARAAAVSPDDVSDVMFTSGTTGRSKGVMSAHRQSVGIAQAWGECAEVTSDDNYLIINPFFHTFGYKAGFLVCLLNGATVVPMAVFDVPKVMATVHDEQITVLPGAPTIFQSILDHPDRPKYDLSSLRVAITGAAAVPVALVERMQSELSFDAVLTAYGQTEAVVVTMCRTDDDPVTVSTTSGRAIPGMEVRIGDQGEILVRGENVMLGYLDDPESTAKTIDADGWLHTGDVGTLDDRGYVDITDRLKDMYISGGFNVYPAEVENALARLDGVAESAVIGVPDERMGEVGRAYVVAKPGVTLAEDDVVAFCKERLANFKVPRSVRFVDSLPRNPSGKVMKNVLREEKK
What is the function of this protein?
Involved in the catabolism of the rings C and D of cholesterol.  Catalyzes the ATP-dependent CoA thioesterification of 3aalpha-H-4alpha(3'-propanoate)-7abeta-methylhexahydro-1,5-indanedione (HIP).
What are the official names of this protein?
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl:CoA ligase, HIP:CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: HIS2_METAC
Sequence: MPEADLSILNRVYDIILDRKENYDENSYVCKLLNHRKGMNKILEKVGEESIETILAVRNEDHKEIVSESSDLIFHLLVLLAANNVTLDEIAGELSARHEKMKRD
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HUTH_CERS4
Sequence: MEILVPGQATLAQLEAIWREGRRARLAPEARPAVEAAAARVAEAAAGTAPVYGVNTGFGKLASLKIAPADTAQLQRNLILSHCCGVGEPMPPSTARLMIALKLLSLGRGASGVRWEIVALLEGMLAAGVTPVIPAQGSVGASGDLAPLAHMAAVMIGEGEAEVGGRRLPGAAALAEAGLAPVALGPKEGLALINGTQFSTAYALAGLFEGWRAAQAALVISALSTDAIMGSTAPLRPEIHALRGHAGQIEAAATMRALLEGSAIRESHREGDQRVQDPYCIRCQPQVTGAAMDVLRMAAGTLATEANAATDNPLVLSDGRIVSGGNFHAEPVGFAADMIALALSEIGAIAQRRVALMVDPTLSFDLPPFLTPEPGLNSGLMIAEVTTAALMSENKHMAAPTVTDSTPTSANQEDHVSMAAHGARRLGRMVENLAVILGTEAICAAQGVEFRAPLATSAPLGAVLARLRAEVPRIAADRILAPDLAAAARLVRTGALARAAGLPFPAL
What are the official names of this protein?
Histidine ammonia-lyase, Histidase.
What is the protein family that this protein belongs to?
Belongs to the PAL/histidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL7_BACP2
Sequence: MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAAAGGAAAEEKTDFDLVLAGAGDQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIAKEEAEELKAKLEEVGASVEVK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.
Protein: DADA_VIBCH
Sequence: MMEVLVLGSGVVGLTSAWYLAQAGHDVTVVDRQPRGAEETSFANAGQISYGYSSPWAAPGIPQKALKWMLEKHAPLKIQPSLDPALLSWMGKMLLNCQLSRYQVNKSRMLAIANYSRECLKALNQTYSLDYQGRQRGTLQVFRDEKQLTAIEKDMQLLAQSGVRFELLNVAQCLTHEPGLAPVQEKLVGGLWLPDDETGDCYLFCQQLTELAKQQGVRFHFDCHIQQLVCEGKKIIGVQTDLGLLKADAYVVALGSYSTSLLKPLGIEIPVYPVKGYSLTLPIIDEKFAPQSTVMDETYKVALTRFSDRIRVAGTAELAGFDPAIPEARKATIEMVARDLFPHGGDFAKGQFWTGFRPMTPDGTPIIGATPYTNLYTNTGHGTLGWTMACGSASILADVLTHGESPLSRLGLDLFRYPKAS
What is the function of this protein?
Oxidative deamination of D-amino acids.
What are the official names of this protein?
D-amino acid dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the DadA oxidoreductase family.
Protein: DRS1_AGASP
Sequence: AVWKDFLKNIGKAAGKAVLNSVTDMVNE
What is the function of this protein?
Probable antimicrobial peptide which stimulates insulin-release in glucose-responsive BRIN-BD 11 cells.
What are the official names of this protein?
Dermaseptin-SP1, DRS-SP1, Dermaseptin-LI1, DRS-LI1, Insulinotropic peptide 1, FSIP.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CBID_PYRAE
Sequence: MNPFLKYGITTGLAAAAAAKAAALYSKGIVPKSVTVPTPIGLRVEVFVERVFQRGEIYCAEVRKFSGDNPDVLNGVIIRACVRPLNNGVVIKGGEGVGIVTRPGLPVPPGEHAINPVPRRMIEEAVREVLEGAEVLVEVPDGKLLAEKTMNPRLGIVGGISILGTTGIEAPVSADEFLGHIEAELSALRERRDIAILAQGNTSYKAAQAVFGDVVVKIGDMVGYAVEKAAALGYKAAYLFTMPGKLAKLALGAYNTHSAQCDGRVEAVLYALVKLRAPYEVLLEVSNAASVGEALAKAGDYAGGVIAIMARRAKEYLERFKIPVEIYVVNDKGEVLFSTT
What is the function of this protein?
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
What are the official names of this protein?
Cobalt-precorrin-5B C(1)-methyltransferase, Cobalt-precorrin-6A synthase.
What is the protein family that this protein belongs to?
Belongs to the CbiD family.
Protein: MUKE_HAES1
Sequence: MTDNIQDLLSIKLARAIANPLFPEVDSQLRSGKHIGQEYLDNYSFLADFQHELDSFYRRYNVELIRAPEGFFYLRPKATTLIARSVLSELEMLVGKVLCYLYLSPERLAQQGIFTVQEVHDELINLADETKLLKAINLRAGGSDLDKQKLAEKVRSAISRLRRLGMIHAVGDQHSGKFTISESVFRFGAEVRSGDDPLEAQLRLIREGEAATAQSLQEEKNGLKDNMDQSAVENEQYFENEENEGIA
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Probably acts via its interaction with MukB and MukF.
What are the official names of this protein?
Chromosome partition protein MukE.
What is the protein family that this protein belongs to?
Belongs to the MukE family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: HEM1_RHOOB
Sequence: MSVLLVGVSHRTAPVPVLERVAVTDTDRPKLTDKLLASSHISEAMIVSTCNRVEIYAVVDAFHGALAEVGELLADHSGLDLTDLHRHAYVRYSEAAAEHLFAVASGLDSMVIGEQQILGQIRTAYASSDAQQAAGRTLHELAQQALRVGKRVHSETGIDSAGASVVSVALDRAAGIVGAGGLTGRTAVVVGAGSMGGLSVAHLTRAGIGRIVVVNRTRERAEHLADTARSNGVAAEALELAELPDAMAQADVLVTCTGAVGAVVTLADTHRALAQPGRDSERPLVICDLGLPRDVEPAVSGLPGVTVLDMESLQRDPAAGAAASDADAARTIVAAELANYLAGQRLAEVTPTVTALRQRAADVVEAELMRLDSRLPGLDDPERDEVARTVRRVVDKLLHAPTVRVKQLASAPGGDSYAAALRELFELSPGSVEAVAKPTELGGADLGAIDITDGFIAGQDPRLRRFVADDNRGKESQA
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: MTB_GYMAC
Sequence: MDPCDCSKSGTCNCGGSCTCTNCSCTSCKKSCCPCCPSGCTKCASGCVCKGKTCDTSCCQ
What is the function of this protein?
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
What are the official names of this protein?
Metallothionein B, MT-B, MT-II.
What is the protein family that this protein belongs to?
Belongs to the metallothionein superfamily. Type 1 family.
Protein: DAPB_YERPY
Sequence: MTDSTIRIAIVGAGGRMGRQLIQAVTQMEGVVLGAAIERKGSTLVGSDAGELAGVGLLNVIVGDDLSQLTDNFDVLIDFTRPEGTLEHLAICRQHRKAMVIGTTGFDEAGKAAISEAAADIGIVFAANFSVGVNVVLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIADAMGRSLKDCAVYSREGYTGERKPGTIGFATVRAGDIVGEHTAMFADIGERVEITHKATSRMTFANGAVKSAIWLGKHDNGLFDMRDVLNLNEL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOH_CAMJD
Sequence: MSDFAFFALEALIKCIIIIAIFASLAGLATYAERKVLAYFQRRIGPDMVGPFGLIQLVADMIKLFTKEDIIPSNSQKFIFAIAPLISAICAFVSLAAIPMLPEFTLFGRVIQPIVADINVALLFVIGTSGLCFYAVFLGGLASNNKWSILGAARGLVAIISYESVGALALIAIVMLVGSFSLVDINNYQSDGFFSWLIFKQPLAFVLFIIALFIETNRTPLCLTENDAEIVAGYGTEYSGLRWGMFFIGEYASMIAGAILVTLLFLGGFNGFWIIPGWIMMIVKSSFIFFWYFWARAAFPQLRPDQVMKMCYLILIPLAVVNLLITALAVLL
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.  This subunit may bind ubiquinone.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit H, NADH dehydrogenase I subunit H, NDH-1 subunit H.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 1 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IRAM_SALTY
Sequence: MEWKVVDTVISPSTGVSFSCIHSLKNLRLTLWYQADVYMPPGSIIIPFNKGVLINDKLYPVTVYNVTRFNPVLWKSLKENSHCPGNCNPKSEACSYPFECLVSVCPFGLTRNIQIDNKKV
What is the function of this protein?
Involved in the stabilization of the sigma stress factor RpoS.
What are the official names of this protein?
Anti-adapter protein IraM, Sigma S-regulator RssC.
What is the protein family that this protein belongs to?
Belongs to the IraM/RssC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VF019_IIV3
Sequence: MTCLKKTGYIYAIENNFNLHVWIGRTTTRSIDECFQTHARLARSRPLCGFQQYMAVYGPENFSIRKIRTVRYTWTMELDLAEEEYSFLCDKGGSKSGAEGDLWSRMVVNDCPAVEFPSTSEVVKLALEHTVEAQPLVPDRFASLLLDERTLAVGTTIKEKLVNGKVYVSPLVLQWIWGHQCRDNFNHQLYHFFKVVNDHKIPHNYIGYREPLVSEFSEIQAEIDHLPTTELTVKRWLVMDAASFREALMLLPTPRCRLVRRYYLAMIECLRLYGCYIHELTHSELDLETQLEMDLKDLKFS
What are the official names of this protein?
Putative MSV199 domain-containing protein 093L.
What is the protein family that this protein belongs to?
Belongs to the IIV-6 019R family.
Protein: MUKB_ECO24
Sequence: MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPMSVQPTQLVTETLNERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFDLGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALRENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRLEEQNEVVAEAIERQEENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADCAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQLVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNSLNQLSEQCGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAYLSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQDIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQGLQNVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLNPQIDMGQRAPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVMVVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISPEKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGSDEAPSQAS
What is the function of this protein?
Plays a central role in chromosome condensation, segregation and cell cycle progression.  Functions as a homodimer, which is essential for chromosome partition.  Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes.  May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
What are the official names of this protein?
Chromosome partition protein MukB, Structural maintenance of chromosome-related protein.
What is the protein family that this protein belongs to?
Belongs to the SMC family. MukB subfamily.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: PK81H_PSEFD
Sequence: MSPMAIEPAGDPEHGAFDRNDNADAVVRSINETHVTYKRLGKTGLRVSVPILGCMSLGDKHWVPWALEEDKALPLLKGAFDLGLNCWDTANVYSNGKSEEIIGKAIKTYQLPRHKLVLLSKCGGYVGEAPNVKGDRYENAISRSKDYVNQGGLSRSAIFEQVEASLRRLDTTYLDVLQIHRFDPNTPIEETMKALHDLVSIGKVRYLGACSMYTYQFAQMQFVAEKNGWTKFVSMQNHYSLLYREEERDMIRFCNETGVGLIPWAPLASGMLTRPATQKVPEGDRAIINRVQEVAEKRGWRMSYVALSWINKRVSAPVIDFDRIDRIEEALATKDKELTAEEEKYVEELYKAKDVEGIPSQR
What is the function of this protein?
Aldo-keto reductase; part of the gene cluster that mediates the biosynthesis of an emodin derivative that may be involved in black Sigatoka disease of banana (PubMed:27388157, PubMed:30735556).  The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase PKS8-1 (Probable).  The atrochrysone carboxyl ACP thioesterase MYCFIDRAFT_190111 then breaks the thioester bond and releases the atrochrysone carboxylic acid from PKS8-1 (Probable).  The decarboxylase MYCFIDRAFT_34057 then catalyzes the concerted decarboxylation-elimination required to convert atochrysone carboxylic acid into emodin anthrone, which is further oxidized to emodin by the anthrone oxygenase MYCFIDRAFT_34418 (Probable).  The functions of the other tailoring enzymes as well as the final product of the cluster have still to be identified (Probable).
What are the official names of this protein?
Aldo-keto reductase MYCFIDRAFT_87468, PKS8-1 gene cluster protein MYCFIDRAFT_87468.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
Protein: F110C_MOUSE
Sequence: MRALPTLDSLARMRPPLGDPRAAEDTLTPRPANKSAVERLAADRAKYVRSTLGSSRGPVSEHRVPEAPGVQHRNPIPSALAPAPVARRAIARKPLRPDSLVIYRQKCEFVRGSDADCSRVGLMKKFFQGSGKDKMAVAPETTRVADEDKTTKETEATWTKSSQAAAARPASMLPPPTPVVAVKSPAEKTRVANEDKTTKETEATWTKSSQAAAARPASMLPPPTPVVAVKSPAEKTRVANEDKTTKETEATWTKSSQAAATRPASMLPPPTPVVAVKSPALPFEVAPRVPVGCSGVQLRVSRSKGLQRSQSDLSSRYSIAKAESDTFFKYCGLDPDVVEALGRENFSAGSDCVTLKVRSVSMAASDSSFSRHSEDGLQEEELLEQVPSTTSVVERNARIIKWLFTCKKAKETPSQKLQGPA
What is the function of this protein?
May play a role in microtubule organization.  May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.
What are the official names of this protein?
Protein FAM110C.
What is the protein family that this protein belongs to?
Belongs to the FAM110 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Colocalizes with microtubules during interphase. Detected at the mitotic spindle poles. Colocalizes with AKT1 at the cell cortex.
Protein: PMTR_ARATH
Sequence: MAFGRGRGNKRTSTSSYASTITMVIFVALCVFGVWMLSSNSVIPPQITQGSTRAAVAETERSDVSASSNGNDEPEPTKQESDEQQAFEDNPGKLPDDAVKSEDEQRKSAKEKSETTSSKTQTQETQQNNDDKISEEKEKDNGKENQTVQESEEGQMKKVVKEFEKEQKQQRDEDAGTQPKGTQGQEQGQGKEQPDVEQGNKQGQEQDSNTDVTFTDATKQEQPMETGQGETSETSKNEENGQPEEQNSGNEETGQQNEEKTTASEENGKGEKSMKDENGQQEEHTTAEEESGNKEEESTSKDENMEQQEERKDEKKHEQGSEASGFGSGIPKESAESQKSWKSQATESKDEKQRQTSESNTVERIMDGNAWVLCNATAGTDYIPCLDNEEAIMKLRSRRHFEHRERHCPEDPPTCLVPLPEGYKEAIKWPESRDKIWYHNVPHTKLAEVKGHQNWVKVTGEFLTFPGGGTQFIHGALHYIDFLQQSLKNIAWGKRTRVILDVGCGVASFGGFLFERDVIAMSLAPKDEHEAQVQFALERKIPAISAVMGSKRLPFPSRVFDLIHCARCRVPWHNEGGMLLLELNRMLRPGGYFVWSATPVYQKLEEDVQIWKEMSALTKSLCWELVTINKDKLNGIGAAIYQKPATNECYEKRKHNKPPLCKNNDDANAAWYVPLQACMHKVPTNVVERGSKWPVNWPRRLQTPPYWLNSSQMGIYGKPAPRDFTTDYEHWKHVVSKVYMNEIGISWSNVRNVMDMRAVYGGFAAALKDLQVWVMNVVNINSPDTLPIIYERGLFGIYHDWCESFSTYPRSYDLLHADHLFSKLRTRCNLVPVMAEVDRIVRPGGKLIVRDESNVIREVENMLKSLHWDVHLTFSKHQEGILSAQKGFWRPETSQ
What are the official names of this protein?
Probable methyltransferase PMT27.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Protein: PYRD_PROMM
Sequence: MAEPSPAKVYSTGGLYRRWLGAILANDQGLDPEQLTQAALSALSQTSLRRDWPGVSAVLAAIALDLQRHDLRLEQVLFGCRFLNPVGLAAGFDKNGVAASIWDRFGFGFAELGTVTWHGQTGNPRPRLFRLAAEQAALNRMGFNNNGAEVMRRTLEKQALPSPGQRPAVLGLNLGKSRITPLEQAPDDYALSLELLAPLADYAVINVSSPNTPGLRDLQDASQLRRLVERLRRLPGCPPLLVKIAPDLEDDAIDGLARLAYEEGLAGVIAVNTSLDRFGLDGRVLPKTGRTLAEEAGGLSGAPLRQRALEVLRRLRATAGPALPLIGVGGIDSPEAAWERISAGASLVQLYTGWIFKGPDLVPNILDGLIGQLDRHGFRHVSEAVGSGVPWQ
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: DDL_CLONN
Sequence: MKKKVAILFGGQSTEHEVSRVSASSVLKNIDLSKYDVYPIGITKDGKWFEYTGAIDKIESGEWEKDEFYKNPNGQEILFNREVDVVFPVMHGLYGEDGTIQGLCKLLTIPCVGPGVMSSAVCMDKVYTKYVLENFGVKQADYVVVNAHDYKNNKMDIISTIENKLGYDVFIKPSNSGSSVGISKAHNREELEAGLEEALKFDRKVLVEVALNAREIEVAVLGNDEPVAATPGEIVPANEFYDYEAKYSNAQSKLLLPANLSPEKLEKVKELAVRIFKMLDCAGMSRVDFLVDKETEEVYLNEINTIPGFTKISMYPKMWQAEGKAYGELISEIIELAVERDNK
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VRK1_MOUSE
Sequence: MPRVKAAQAGRPGPAKRRLAEQFAAGEVLTDMSRKEWKLGLPIGQGGFGCIYLADTNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLSHKNPDQVYLVDYGLAYRYCPDGVHKEYKEDPKRCHDGTLEFTSIDAHKGVAPSRRGDLEILGYCMIQWLSGCLPWEDNLKDPNYVRDSKIRYRDNVAALMEKCFPEKNKPGEIAKYMESVKLLEYTEKPLYQNLRDILLQGLKAIGSKDDGKLDFSAVENGSVKTRPASKKRKKEAEESAVCAVEDMECSDTQVQEAAQTRSVESQGAIHGSMSQPAAGCSSSDSSRRQQHLGLEQDMLRLDRRGSRTRKKAQK
What is the function of this protein?
Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation (PubMed:14645249, PubMed:9521809, PubMed:33076429).  Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation (By similarity).  Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2 (By similarity).  Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429).  Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (By similarity).  Phosphorylates ATF2 which activates its transcriptional activity (By similarity).
What are the official names of this protein?
Serine/threonine-protein kinase VRK1, Serine/threonine-protein kinase 51PK, Vaccinia-related kinase 1.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.