Protein: SIRP_LEPMC
Sequence: MHITKDIDTIFHRSLEGLTGDDHSPESRRDFPMSQSSGCRNGTDATVCHIFERIASQFPESVAAEDGGRNITYGELHYASNHLANHLSQIGIQSGQKIVIISNRSLEMIVALLGIMKSGACVVPIDFETWSQDRIQTTLETTQCRYAISTKCIEIPNQELILFQEGDLQHVLDNRRDQPASFSTRGFQLPSADDLAYTIFTSGTTSKPKGVMVPHSAIAHYVQQVSDEAPFNLNVQASSRVLLVFSVAFDACLGVVLSTICNGGTLILATSMNFATVATTCTILPLTPTILSTLRPGAEYDSIKSIFLGGESPSPNLLRPWLNGERRIFNCYGPTETTCTSLIKEVLPDEPNHLRYTVAGSSVVLLDGNLREVSEGEIAISGPGLAVGYFNNQALTAEKFIVYKGVRHYLTGDYGRKTSFGIDFLGRKDRVVKNRGFLINLEAEVEAVITNMKLANSAAALMHEGRLIMFVTPETIDVSSLRSRLLEIRDSFLVPDRIYAICSFPITSNGKVDLASLRQLLQEEKFTGVATHQSSPSSNLYVVLEGFSKVLGLPPSALCGSSSFLDNGGNSLSAVSLASHLRERGLSITVREIFESDTAQRICDTLSATILSTSDSEEADLESLRENVVRAGYPLTPRMEVAYMTAIQVNMIQSTIKMPSMNYIQLSITFDLSSGLFKPEVFRRAWEIIVQRHSILRATFIPALEATVIAADPTMDWREQLVDSSEWDSAVADAREKILCSMAPLDAEYLKPRSIFRLITEPKSRTEFIWTIHHSLVDGWSIAVIMRDLQCILSQEELPKVAQFTSVATVQKALAQRSLSRGKQQSWEEKMQNYIPAPRLRLPKPQGWARAARAERRQLLGVHRSQVQRFVQEYRVSDASIFLASWALVLSKYLSTDRVLFGVVLSGRNLPMAAVDQVVGPLLDTVPFPVNTTSTQSTAEFLRTIHGTLHEMNESPWEMKLQKSSMGPESLETLVALQYDLPDSTWNVDPKTWPSPQSMKHNETTELPLHILIDMQNGGDLEARYLYDCSHFEAAMIDQMLSHFSNMLKAILMHPTVELVKSSMMNQLEINDLLYSSPHMHDAYDGPQSLKQAFEEVVDTWPDAIAVESVSDSISYKELDHRSSAISNALLPLVGPGQIVGILSDGSVSWITAILAVLKAGAAYCPIDIALPEERIKVMLRESRCSLLLCTTEDLCELWANHSDLTCFSIGRLLSETLQTPERLPERCSPHDPAAVIFTSGSTGVPKGILLEHIGILSLLDFPNARLRSGPGRRNAQFLSLGFDCCVNEVFATLCYGATLVLRDPLDPVQHIKRVHATMCTPSFLATLDVNDFPNLELIALAGEPVPQKLVDTWGHNRVLLNVYSPSECTISTVYPQLYPGVQVTLGSPVPRQAIYILDKDLNPVPVGVPGEICISGIQVTRGYLNRPEETLVKFLPNPFQKGWRLYRSGDLGRLTNSHEIEYIGRIDNQVKVRGFRIELEEIESTIAALNPEVRQAAVIVVNDVLIGFVTPSSLDTLAIQAIISRHLPSYCRPSYFVALDNMPMSSNQKIDRKKLVSMKAERNHFTKVPIEGTTERIIQEIWKDLIPELGEVSALDNFLQIGGHSLLQARLTRQLGMALGNRIPLRIVIQNPVLRDLALAIDKHILDGGSEDISRGQPEQNTVLSHLEEEMYTVHMLSSEPSAWNIPYIARLTGPLNLAAFEASWNNIIRSNSILRARYQIKDGILTRSISTSISPVTRRYCKVTDDALLDIVNRAFDLANDQPIRLDLCLDRPTMSYVVLNMSHMIGDRSTMGEILRLLEEEYAQMILNDNFNLHEPLSESLPYSVWTAMRRKREVDAGLTHVLQKSLNPSLINPPLFGTFKQELACSAHRDKRIEGDLFSSLKNLRGRFKASGHQLAIAAIGLTLHRLSHREDFIIAAPIEDRTEAGTENMFGLFLDRLLIPLRFNLHSPHSADDLIHMVKSASEQAMANYIPFADLKNVLGMVGKSHSLCEIMVTYHASDLQGPNLTGVDALGIPVQPKGVKFPLMLEFSEFPESIGIDLAYDSHAIDNATMDEFEVQLMAAFRYLADETCSSTCTTYPPRLFPLIWSQKDTNTVAPISEDQEMIDLVREAMAECVGLNRCDISCSRSFFELGGSSVDCLRLQDRLIKSGVSVSLSSIIHLQTAELIAGAVE
What is the function of this protein?
Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of sirodesmin PL, an epipolythiodioxopiperazine (ETP) characterized by a disulfide bridged cyclic dipeptide and that acts as a phytotoxin which is involved in the blackleg didease of canola (PubMed:15387811, PubMed:18272357, PubMed:19762440).  SirD catalyzes the O-prenylation of L-tyrosine (L-Tyr) in the presence of dimethylallyl diphosphate (DMAPP) to yield 4-O-dimethylallyl-L-Tyr, and therefore represents probably the first pathway-specific enzyme in the biosynthesis of sirodesmin PL (PubMed:19762440, PubMed:21038099, PubMed:24083562).  4-O-dimethylallyl-L-Tyr, then undergoes condensation with L-Ser in a reaction catalyzed by the non-ribosomal peptide synthase sirP to form the diketopiperazine (DKP) backbone (PubMed:18272357).  Further bishydroxylation of the DKP performed by the cytochrome P450 monooxygenase sirC leads to the production of the intermediate phomamide (PubMed:27390873).  This step is essential to form the reactive thiol group required for toxicity of sirodesmin PL (PubMed:27390873).  The next steps of sirodesmin biosynthesis are not well understood yet, but some predictions could be made from intermediate compounds identification (PubMed:18272357).  Phomamide is converted into phomalizarine via oxidation, probably by sirT (PubMed:18272357).  Further oxidation, methylation (by sirM or sirN) and reduction steps convert phomalizarine to deacetyl sirodesmin (PubMed:18272357).  Finally, acetyltransferase sirH probably acetylates deacetyl sirodesmin to produce sirodesmin PL (PubMed:18272357).
What are the official names of this protein?
Nonribosomal peptide synthetase sirP, NRPS sirP, Sirodesmin biosynthesis protein P.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.