PharMolix/UniProtQA huggingface dataset:
Protein: RBL1_MOUSE
Sequence: MFEDEPHAEGAAAVAAAREALQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVIHWLACSLYVACRKSIIPTVGKGVMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKFEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRRDLLNPSFKGLPSDFHAPDFKAAEEPPCIIAVLCDLHDGLLVEAKGIKEHYFKPYISKLFDKKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTADTPFGKLTSQASVECNLQQHFEKKRSFAPSTPLTGRRYLQEKEAVTTPVASATQSVSRLQSIVAGLKSAPSEQLLNIFESCMRNPMGNIIKIVKGIGETFCQHYTQSTDKQPGSHIDFAVNRLKLAEILYYKILETIMVQETRRLHGMDMSVLLEQDIFHKSLMACCLEIVLFAYSSPRTFPWIIEVLDLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWTNNSALWEALHASANRVPSCEEVIFPNNFEIGNGGNVQGHLPMMPMSPIIHPRVKEVRTDSGSLRQDMQPLSPISVHERYSSPAAGSAKRRLFGDDPPKDTLMDKIMAEGTKLKIAPSSVTAESLSISPGQALLTMATTTVTGTTGRKVTVPLHGIANDAGEITLVPISMNPTQESTAESPVSLTAQSLIGTSPKQTHLTKAQDAHLTGVSKPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKSIPGGVVVYNGDCEMTDGDIEDATKTPNCSSEPVKEERGDLIKFYNTVYVGRVKSFALKYDLSNQDHIMDAPPLSPFPHIKQQPGSPRRISQQHSLYVSPHKNGAGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQKTKKRVIAISGDADSPAKRLCQENDDVLLKRLQDVVSERANH
What is the function of this protein?
Key regulator of entry into cell division (By similarity).  Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (PubMed:15750587).  Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (PubMed:15750587).  Controls histone H4 'Lys-20' trimethylation (PubMed:15750587).  Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (PubMed:15750587).  Potent inhibitor of E2F-mediated trans-activation (By similarity).  May act as a tumor suppressor (By similarity).
What are the official names of this protein?
Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1.
What is the protein family that this protein belongs to?
Belongs to the retinoblastoma protein (RB) family.
What are the subcellular locations of this protein?
Nucleus.
Protein: ODPB_SOLTU
Sequence: ISAVKEMTVRDALNSA
What is the function of this protein?
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).  It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
What are the official names of this protein?
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial, PDHE1-B.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: RT63_BOVIN
Sequence: MFLTALLCRGRIPGRQWIGKHRRPRTVSALAKQNMIRRLEIEAENHYWLSRPFLTAEQERGHAAARRAAAFEALKAAQAAKFPAHRRLEDQLDHLNVTRKWS
What are the official names of this protein?
Ribosomal protein 63, mitochondrial, Mitochondrial ribosomal protein 63, Mitochondrial ribosomal protein L57, bMRP63.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL63 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: PMI1_ARATH
Sequence: MAGEYSGSRSSNTQLLAELEALSENLYQKPQVSVGNRRTNSLALPRSSVPSLVTSADEVSTARAEDLTVSKPRARRLSLSPWRSRPKLEVEEEENVTQSNRIVKKPEESSSGSGVKEEKKGIWNWKPIRGLVRIGMQKLSCLLSVEVVAAQNLPASMNGLRLGVCVRKKETKDGAVQTMPCRVSQGSADFEETLFIKCHVYYSPANGKGSPAKFEARPFLFYLFAVDAKELEFGRHVVDLSELIQESVEKMNYEGARVRQWDMNWGLSGKAKGGELALKLGFQIMEKDGGAGIYSKQGEFGMKPSSKPKNFANSFGRKQSKTSFSVPSPKMTSRSEAWTPASGVESVSDFHGMEHLNLDEPEEKPEEKPVQKNDKPEQRAEDDQEEPDFEVVDKGVEFDDDLETEKSDGTIGERSVEMKEQHVNVDDPRHIMRLTELDSIAKQIKALESMMKDESDGGDGETESQRLDEEEQTVTKEFLQLLEDEETEKLKFYQHKMDISELRSGESVDDESENYLSDLGKGIGCVVQTRDGGYLVSMNPFDTVVMRKDTPKLVMQISKQIVVLPEAGPATGFELFHRMAGSGEELESKISSLMAIDELMGKTGEQVAFEGIASAIIQGRNKERANTSAARTVAAVKTMANAMSSGRRERIMTGIWNVEENPLTSAEEVLAVSLQKLEEMVVEGLKIQADMVDDEAPFEVSAAKGQKNPLESTIPLEEWQKEHRTQQKLTVLATVQLRDPTRRYEAVGGTVVVAVQAEEEEEKGLKVGSLHIGGVKKDAAEKRRLTAAQWLVEHGMGKKGKKKSNIKKKEKEEEEEEMLWSLSSRVMADMWLKSIRNPDVKLH
What is the function of this protein?
Necessary for chloroplast and nuclear photorelocation movements via the regulation of chloroplast-actin (cp-actin) filaments in mesophyll cells, and together with PMIR1, in pavement cells (PubMed:26324877).  Required component for both the low- and high-light-dependent chloroplast movement responses via an abscisic acid (ABA) pathway (PubMed:16113226, PubMed:25154696).  Involved in the ABA response pathway during seed germination.  Modulates ABA accumulation during periods of water deficit at the seedling stage (PubMed:25154696).
What are the official names of this protein?
Protein PLASTID MOVEMENT IMPAIRED 1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROS_AVISU
Sequence: DTVTSPDITAIVAVIGAVVLGLTSLTIIILFGFVWHQRWKSRKPASTGQIVLVKEDKELAQLRGMAETVGLANACYAVSTLPSQAEIESLPAFPRDKLNLHKLLGSGAFGEVYEGTALDILADGSGESRVAVKTLKRGATDQEKSEFLKEAHLMSKFDHPHILKLLGVCLLNEPQYLILELMEGGDLLSYLRGARKQKFQSPLLTLTDLLDICLDICKGCVYLEKMRFIHRDLAARNCLVSEKQYGSCSRVVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLIDGVFTNHSDVWAFGVLVWETLTLGQQPYPGLSNIEVLHHVRSGGRLESPNNCPDDIRDLMTRCWAQDPHNRPTFFYIQHKLQEIRHSPLCFSYFLGDKESVAPLRIQTAFFQPL
What are the official names of this protein?
Tyrosine-protein kinase transforming protein ros.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Protein: ABDH_ECOL5
Sequence: MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVNAAVRAADAAFAEWGQTTPKARAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINVLFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTAPSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGSPDDESTELGPLSSLAHLERVSKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTLFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVKH
What is the function of this protein?
Catalyzes the oxidation 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA).  This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4-aminobutanal.  Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
What are the official names of this protein?
Gamma-aminobutyraldehyde dehydrogenase, ABALDH, 1-pyrroline dehydrogenase, 4-aminobutanal dehydrogenase, 5-aminopentanal dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family. Gamma-aminobutyraldehyde dehydrogenase subfamily.
Protein: CYB_VULLA
Sequence: MTNIRKTHPLAKIVNDSFIDLPAPSNISAWWNFGSLLGVCLILQIMTGLFLAMHYTSDTATAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYVFMETWNVGIILLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFIFPFIIAALAMVHLLFLHETGSNNPSGITSDSDKIPFHPYYTIKDILGILLLLSVLMSLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVFSILILALIPHLHTSKQRGMMFRPLSQCLFWLLTADLLTLTWIGGQPVEHPFIVIGQIASILYFAILLILMPTISIIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: DCTA_SINMW
Sequence: MLPDWACHVEDIMIIEHSAEVRGKTPLYRHLYVQVLAAIAAGILLGHFYPDIGTQLKPLGDAFIRLVKMIIAPVIFLTVATGIAGMTDLAKVGRVAGKAMIYFLAFSTLALLVGLVVANLVQPGAGMHIDPASLDAKAVATYAQKAHEQSITGFLMNIIPTTLVGAFAEGDILQVLFISVLFGISLAIVGKKAEPVVDFLQALTLPIFRLVAILMKAAPIGAFGAMAFTIGKYGIASIANLAMLIGTFYLTSFLFVFVVLGAVARYNGFSILSLVRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATDTPLSYGDQILLLLVAMLSSKGAAGITGAGFITLAATLSVVPSVPVAGMALILGIDRFMSECRALTNFVGNAVATIVVAKWEGELDQAQLSAALGGEMQVETIPAVVVQPAE
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUSB_SHEON
Sequence: MKPSERRKARRLAVQAIYSWQLSGNNIADVEHEFLTEQSLDGVDVAYFRELFAGVATKKTQLDELIIPHLDRPIDEVSPVEKAIVRLAAYELTFRKDVPFKVAINEAIELAKAFGADESHKFVNGLLDKLVARK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: LEUD_CAUVC
Sequence: MKAFTRLDGRAAPLELANIDTDQIIPKQFLKTVEREGLAKGLFYDFRFDADGNEISDFVLNKPEYKSASVLIAGDNFGCGSSREHAPWALMDFGIMCVISTSFADIFNNNCFNNGLLPVVVSPEDLALLMDEAKGGNHMVSVDLEAQTVISPSGKTIGFDIDPVRKEKMLKGLDAIGETMMHGGDIDLFESKRAISQPWLEA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: TAAR1_RAT
Sequence: MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
What is the function of this protein?
Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR.  Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin.  Trace amines are biogenic amines present in very low levels in mammalian tissues.  Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative.  Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.  The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
What are the official names of this protein?
Trace amine-associated receptor 1, TaR-1, Trace amine receptor 1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y805_CHLTE
Sequence: MAMPNFGDMMKQLQEAGAKMQDLQKQLEKLVSEGEAGGGMVRAKVNGRQKLLELTIDPEIMDDVDMVQDLVVAAVNKALEASAQLAQSEIQKAAGGMINPADLMKQFGGQG
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein CT0805.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: DDI1_MOUSE
Sequence: MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGLRTPGRTPNHPRADFTGSGSAVPGTSSSRHPHQHQHHYHHHQRIPSTQQAHGLASGENMTFAQELDSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLMEQQRERTLREQEMFRLYSTNPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWGGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGTVQEESSDREVGGTIKHPVKGPGRKKH
What is the function of this protein?
Probable aspartic protease (By similarity).  Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2.  Required, with DDI2, for cellular survival following replication stress.  Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity).
What are the official names of this protein?
Protein DDI1 homolog 1.
What is the protein family that this protein belongs to?
Belongs to the DDI1 family.
Protein: PSBJ_PROM3
Sequence: MSTKLKGPDGRIPDRLPDGTPAVSWERRWTEGSLPLWLVATVGGMAVLSVLGLFFFGSFTGVGSA
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: LUXS_SHEPW
Sequence: MPLLDSFTVDHTRMNAPAVRVAKSMSTPKGDTITVFDLRFCVPNKQILSERGIHTLEHLFAGFMRDHLNGDNVEIIDISPMGCRTGFYMSLIGAPSESIVADAWLAAMQDVLAVVEQSEIPELNEYQCGTYEMHSLEQAKEIARSIISAGINVNRNDELTLSDEILNGL
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: Y1023_ACTP7
Sequence: MEYQFTHSIHGVVAKCSMDHEAFARWLNTEITENPKELINIFAEIEKCRAAYPNHYECVFEGKEYSLFLDCDEVMVKANNLDDAFDESQMEDGFQFYDQESIAFCGLEDFENFLKAYQKFSKTYH
What are the official names of this protein?
UPF0231 protein APP7_1023.
What is the protein family that this protein belongs to?
Belongs to the UPF0231 family.
Protein: GPR_OCEIH
Sequence: MEEQQIPFQVRTDLAIEAKDMYTESKPEETNDKEIKGVTFKERSVKDIKVSYVDIDEEGEKLLGKKPGSYVTIYADGVKKQDTDRQGQAAQVLAKELEDLMRKNNVTKESTCLVVGLGNWNVTPDALGPMTVEKVLVTSHLFRLQYETVAQGYRDVAAVTPGVMGVTGIETSDIIFGIVEKYKPDLVIAVDALASRSINRVNETIQLSDTGIHPGSGVGNKRKEISKKTLGIPVIAIGVPTVVDAVTITSDTIDYVLKHFGREWKEKDDPSKSLTPAGMSFGNRKLTDEDLPNMEKRKTVLGIVGELSDEEKRKLITEVLTPLGHNLMVTPKEVDGFMIDMAEVLANGINAALHEKVDVDNFANYSR
What is the function of this protein?
Initiates the rapid degradation of small, acid-soluble proteins during spore germination.
What are the official names of this protein?
Germination protease, GPR endopeptidase, Germination proteinase, Spore protease.
What is the protein family that this protein belongs to?
Belongs to the peptidase A25 family.
Protein: RL39_SULIM
Sequence: MSRNKPVAKKFRLAKALKANSPIPIWIVLKTRGRVRYNPLRRNWRRNDLKV
What are the official names of this protein?
50S ribosomal protein L39e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL39 family.
Protein: AL9A1_BOVIN
Sequence: MSTGTFVVSQPLNYRGGARVEPVDASGTEKAFEPASGRVIATFTCSGEKEVNLAVQDAKAAFKIWSQKSGMERCRILLEAARIIRERRDEIATMETINNGKSIFEARWDIDTSWQCLEYYAGLAGSMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIACWKSAPALACGNAMVFKPSPFTPVSVLLLAEIYTEAGVPPGLFNVVQGGAATGQFLCQHRDVAKVSFTGSVPTGSKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMKNAVKGALMANFLTQGEVCCNGTRVFVQKEILDQFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDVFVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGMCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF
What is the function of this protein?
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro).  Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency.
What are the official names of this protein?
4-trimethylaminobutyraldehyde dehydrogenase, TMABA-DH, TMABADH, Aldehyde dehydrogenase family 9 member A1.
What is the protein family that this protein belongs to?
Belongs to the aldehyde dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: HEM1_SALAI
Sequence: MKLLVVGASYRTAPVAALERLAVAPADLPHALARLVAQPYVSEAVLVSTCNRVEVYAAVSGFHGGLGDICAVLAESTGVPPAALADHLYVHFDAAAVKHAFRVATGLDSMVVGEAQILGQLRDAYHWASGADTTGRLLHELMQQALRVGKRAHSETGIDRAGQSVVTAALGLATELLNSDLAARPALVVGAGAMGSLGVATLSRLGAGPVAVTNRGADRAVRLAESYGATAVPIADLTATLSTVDIVVAATAAPEAVLTREVVTRALADRKPSRGPLVLLDLAVPRDVEPGVADLPGVQVIDIDRMAALVANGPAAADAAAVERIVATEVDAFLNWLRGADVAPTVAALRGRADNVVTVELGRLAQRRPDLTDDQRDEVARTVHRVVQRLLHQPTVRVRQLAAEPGGDQYAALLRELFDLEVPQTSPVGTVPEVVVPEAVPPLGGAAEDPSTGGQ
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase, GluTR.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: EMTA_SHIDS
Sequence: MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGVLLRTFSSDRKKAISKINDLDADEFLDHVARNHPAPQAPRYIYKLEQALDAM
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.  Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain.
What are the official names of this protein?
Endo-type membrane-bound lytic murein transglycosylase A, Peptidoglycan lytic endotransglycosylase.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: KUN1_RHIHE
Sequence: MKILQYALLACLLVSILGDDDDEENEGAAGSDDAGATPTALSKPAATSAEGNTAAKNSGGDIKQPKQELPEPSSKGQKKPRLPKRCLFKPEQGNCAGSRFLPRWWYNPETESCEPFTYPVCNKKNEAFVSCTLCMNMCMRNKRGREKAKWIRKVCRKSPKVKSG
What is the function of this protein?
Anticoagulant protein that may inhibit serine proteases.  The anticoagulant effect of this recombinant protein on blood clotting is found both in the recalcification time (RT) and the activated partial thromboplastin time (APTT) tests, indicating it acts in the common pathway of blood coagulation.
What are the official names of this protein?
Anticoagulant protein rhipilin-1.
What are the subcellular locations of this protein?
Secreted.
Protein: PPP6_HUMAN
Sequence: MAPLDLDKYVEIARLCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
What is the function of this protein?
Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700).  PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379).  N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194).  During mitosis, regulates spindle positioning (PubMed:27335426).  Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228).  Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (PubMed:29053956).  Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32753499, PubMed:32474700).  CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700).
What are the official names of this protein?
Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm.
Protein: HGD_PONAB
Sequence: MAQLKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLYRIPPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKVSQKKVDLVSGLHTLCGAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEICVIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDRQVPGGYTVIDKYQGKLFAAKQGVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPGGGSLHSTMTPHGPDADCFEKASKAKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLDENYHKCWEPLKSHFTPNFRNPAEPN
What is the function of this protein?
Catalyzes the conversion of homogentisate to maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: MDH_STRM5
Sequence: MKAPVRVAVTGAAGQIGYALLFRIASGEMLGKDQPVILQLLELPVDKAQAALKGVMMELEDCAFPLLAGMVGTDDAEVAFKDADIALLVGARPRGPGMERKDLLLENAKIFTAQGAALNKVASRDVKVLVVGNPANTNAYIAMKSAPDLKPENFTAMLRLDHNRALSQLSAKLGKPVGGMEKLVVWGNHSPTMYPDYRFATADGASIADAINDQEWNANTFIPTVGKRGAAIIEARGSSSAASAANAAIDHVRDWVLGSNGKWVTMGVPSDGSYGIPEGVIFGFAVTTENGKYTLVKDLPVDDFSQKYIDKTLAELEEERSGVAHLLG
What is the function of this protein?
Catalyzes the reversible oxidation of malate to oxaloacetate.
What are the official names of this protein?
Malate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Protein: PMIP_YARLI
Sequence: MRRFSTLSRRLQRVVPASSASTANTSPSPALYTGLEPKIKESQDSLIRAVFDNGDVWQDFSQKSVAKPKQSRSITGFINYLTNESDYETGLFMNDFLKTPAGFQKYTAASIEEAGQLIQQLLGALTQRDKLRHAITTFDRLSDVLCQVIDLAEFIRAAHPEQHFVQAAQEAHEQMYEYMNVLNTSVELYTVLDMVFKDSEIVNQLTHEEKVVGTLLLEDFKKSGVTLDDAGRENFVSLTTKISLLGRDFISSNHPKEDYITLTQGEAQGLDPQLAQQLSQGNSVYVPTGGVPGQLALRGMKNENSRKLLWSKMRESSDKSIESLEDLLVSRLELANLMGKESYADYLLSDKMAGNPENVMRFLNGLLDKTLPGAKKELSVLEQIKKQATGNPKSILQAWDKSYYASQLLYQKRNKTKTAHMLSEYFSVGTVVQGLSRIFDKIYGIRFVPTETKTGETWHHDVRRLDVVSETEGLIGIMYADLFQREGKSPNPAHFTVRCSREIYPDELAHMSSSPIAKVPTLNLNGKVFQIPTIALICDFTTPHDLYPSLLSYQEVETLFHEMGHAIHSMLGRTSLHNVCGTRCATDFVELPSVFMENFASNPESLALFARHYSSDSPLPYQQLERHLNEQSYFKDVEQYTQIKMAMLDQVLHGNILKSITNGHFNSQKLYDNLEKDRPLFPPSPSSWHGSFGHLFGYGASYYCYLLDRQMADIVWKKLFSKNPLSRDAGSRMKNEVLQWGGSRDPWECIAGVLEDPELAKGGSQAMEKIGNYDKH
What is the function of this protein?
Cleaves proteins, imported into the mitochondrion, to their mature size.  While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
What are the official names of this protein?
Mitochondrial intermediate peptidase, MIP, Octapeptidyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M3 family.
What are the subcellular locations of this protein?
Mitochondrion matrix.