PharMolix/UniProtQA huggingface dataset:
Protein: ZNT1_MOUSE
Sequence: MGCWGRNRGRLLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAVERFIEPHEMQQPLVVLSVGVAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKGARKAGRAGVEAGAPPGRAPDQEETNTLVANTSNSNGLKADQAEPEKLRSDDPVDVQVNGNLIQESDNLEAEDNRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFNWKGCTEDDFCTNPCFPDPCKSSVEIINSTQAPMRDAGPCWVLYLDPTLCIIMVCILLYTTYPLLKESALILLQTVPKQIDIKHLVKELRDVDGVEEVHELHVWQLAGSRIIATAHIKCEDPASYMQVAKTIKDVFHNHGIHATTIQPEFASVGSKSSVLPCELACRTQCALKQCCGTRPQVHSGKDAEKAPTVSISCLELSENLEKKARRTKAEGSLPAVVIEIKNVPNKQPESSL
What is the function of this protein?
Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (Probable).  Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism.  By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells.  By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (PubMed:15451416).  In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles.  In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (By similarity).
What are the official names of this protein?
Proton-coupled zinc antiporter SLC30A1, Solute carrier family 30 member 1, Zinc transporter 1, ZnT-1.
What is the protein family that this protein belongs to?
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PDXY_ACTP2
Sequence: MKNILSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWKGIVMPKEQIGEIIQGIDEIGELAKCDAVLSGYIGSAEQVTEIVNAFHTVKSRNPNAIYLCDPVMGHPDKGRIVADGVKEGLIKQAMAHADIITPNLVELRELSGLRVENFEQAIEAVKVILTKGPKKVLVKHLSKVGKQADKFEMFFATEEGIWHISRPLYQFDKEPVGVGDLTAGLFLANLLNGKSDIEAFEHTANAVNDVMEVTANSGVYELQIIAAREFILTPRSQYKAIKIV
What is the function of this protein?
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP).  Catalyzes the phosphorylation of pyridoxal to PLP.
What are the official names of this protein?
Pyridoxal kinase PdxY, PL kinase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxine kinase family. PdxY subfamily.
Protein: TNNC1_HOMAM
Sequence: MDTLDEDQVQALQKAFNSFDTDDKGFITPDTVGVILRMMGVKISDRHLQEVISETDEDGSGEIEFEEFAALAAKFLSEEDEEALKKELKEAFRIYDRGGNGYITVHTLKEILRELDNKLTEDNLDSIIEEVDEDGSGTIDFNEFMKMMNG
What is the function of this protein?
Troponin is the central regulatory protein of striated muscle contraction.  Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C.  The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
What are the official names of this protein?
Troponin C, isoform 1.
What is the protein family that this protein belongs to?
Belongs to the troponin C family.
Protein: NU4LM_LYNCA
Sequence: MSMVYINIFMAFTVSLMGLLVYRSHLMSSLLCLEGMMLSLFIMMTMAILNNHFTLASMAPIILLVFAACEAALGLSLLVMVSNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: IHFB_CERS4
Sequence: MIRSELIQKIADENPHLTQRHVERIVNTVFEEIIEALARGDRVELRGFGAFSVKARDARVGRNPRTGEAVEVEDKKVPFFKTGKLLRDRLNAK
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: GAUTA_ARATH
Sequence: MRRRGGDSFRRAGRRKISNVVWWVLSGIALLLFFLILSKAGHIEPRPSIPKRRYRNDKFVEGMNMTEEMLSPTSVARQVNDQIALAKAFVVIAKESKNLQFAWDLSAQIRNSQLLLSSAATRRSPLTVLESESTIRDMAVLLYQAQQLHYDSATMIMRLKASIQALEEQMSSVSEKSSKYGQIAAEEVPKSLYCLGVRLTTEWFQNLDLQRTLKERSRVDSKLTDNSLYHFCVFSDNIIATSVVVNSTALNSKAPEKVVFHLVTNEINYAAMKAWFAINMDNLRGVTVEVQKFEDFSWLNASYVPVLKQLQDSDTQSYYFSGHNDDGRTPIKFRNPKYLSMLNHLRFYIPEVFPALKKVVFLDDDVVVQKDLSSLFSIDLNKNVNGAVETCMETFHRYHKYLNYSHPLIRSHFDPDACGWAFGMNVFDLVEWRKRNVTGIYHYWQEKNVDRTLWKLGTLPPGLLTFYGLTEALEASWHILGLGYTNVDARVIEKGAVLHFNGNLKPWLKIGIEKYKPLWERYVDYTSPFMQQCNFH
What is the function of this protein?
May be involved in pectin and/or xylans biosynthesis in cell walls.
What are the official names of this protein?
Probable galacturonosyltransferase 10, Like glycosyl transferase 4.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 8 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: F16PA_RHOPB
Sequence: MHQGLTLSRHTNEYAGTDKLRLAVAAAIDAIAAASIDISELIGRGPLAGITGEAQGSSNADGDVQKDLDVRCDEMILAGLQKIPYAALASEESETLVLGDPGAPISVAFDPLDGSSNIDTNMTVGTIFSIVPNKQGEAPFSAPGNVQLAAGFVVYGPQTSLVLTLGNGVDIFTLDRRDRTYKCIRQQVQIPEHTAEFAINASNHRHWEQPVRDFVEECLAGADGPRSKDFNMRWIGSLVAEAYRILTRGGIFLYPGDSRPGYGDGRLRLLYECHPMAFIIEQAGGGASTGRERVLDLAAKSIHQRAPLIMGSVDKVQRIELLHNDPAAATITAPLFGHRGLFRV
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VSPH1_VIPAA
Sequence: MVLIRVLANLLVLQLSYAQKSSELVIGGDECNINEHPFLVALHTARSKRFYCAGTLINQEWVLTAARCDRKNIRIILGVHSKNVPNEDEQMRVPKEKFFCLSSKTYTRWDKDIMLIRLKRPVNDSTHIAPLSLPSSPPSVGSVCRIMGWGTITTTKVTYPDVPHCADINMFDYSVCQKVYRKLPEKSRTLCAGILQGGIDSCKVDNGGPLICNGQIQGIVSWGGYPCAQPHKPALYTNVFDYTDWIQSIIAGNITATCPP
What is the function of this protein?
This is the first member of the serine protease family that has strong anticoagulant activity and lacks enzymatic activity.  It inhibits activities of three blood coagulation complexes: (1) prothrombinase complex (composed of blood coagulation factors Va and Xa (F5 and F10)) (IC(50)=164. 1 nM), (2) intrinsic tenase complex (composed of factors VIIIa and IXa (F8 and F9)), and (3) extrinsic tenase complex (composed of tissue factor and factor VIIa (F7)).  The toxin has also been observed to bind prothrombin, factor FVa, non-activated and activated forms of factors FVII (F7) (FVII and FVIIa), factor FVIIIa (F8), factors FIX and FIXa (F9) and factors FX and FXa (F10).  The toxin inhibits the activity of the intrinsic tenase complex mainly by competing with FIXa (F9) for binding to FVIIIa (F8).
What are the official names of this protein?
Vaa serine proteinase homolog 1, VaaSPH-1, Enzymatically inactive serine proteinase-like protein SPH-1, Snake venom serine protease homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family. Snake venom subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: Y1568_NEIMF
Sequence: MSIQSGEILETVKMVADQNFDVRTITIGIDLHDCISTDIDVLNQNIYNKITTVGKDLVATAKYLSAKYGVPIVNQRISVTPIAQIAAASKADSYVSVAQTLDKAAKAIGVSFIGGFSALVQKGMSPSDEVLIRSIPEAMKTTDIVCSSINVGSTRAGINMDAVKLAGETIKRTAEITPEGFGCAKIVVFCNAVEDNPFMAGAFHGSGEADAVINVGVSGPGVVKAALENSDATTLTEVAEVVKKTAFKITRVGELIGREASKMLNIPFGILDLSLAPTPAVGDSVARILEEMGLSVCGTHGTTAALALLNDAVKKGGMMASSAVGGLSGAFIPVSEDEGMIAAAEAGVLTLDKLEAMTAVCSVGLDMIAVPGDTPAHTISGIIADEAAIGMINSKTTAVRIIPVTGKTVGDSVEFGGLLGYAPVMPVKEGSCEVFVNRGGRIPAPVQSMKN
What are the official names of this protein?
UPF0210 protein NMC1568.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: HISX_MYCTU
Sequence: MTAPPPVLTRIDLRGAELTAAELRAALPRGGADVEAVLPTVRPIVAAVAERGAEAALDFGASFDGVRPHAIRVPDAALDAALAGLDCDVCEALQVMVERTRAVHSGQRRTDVTTTLGPGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQAAGVDSLVVASPPQAQWDGMPHPTILAAARLLGVDEVWAVGGAQAVALLAYGGTDTDGAALTPVDMITGPGNIYVTAAKRLCRSRVGIDAEAGPTEIAILADHTADPVHVAADLISQAEHDELAASVLVTPSEDLADATDAELAGQLQTTVHRERVTAALTGRQSAIVLVDDVDAAVLVVNAYAAEHLEIQTADAPQVASRIRSAGAIFVGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVSGHVITLATAEDLPAHGEAVRRRFER
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: CUPB_DICDI
Sequence: MINIEDISKSSNQSEEKQLKSTSSKPKYSFAAKSLFKGSNNITPYYLSTSNTFQCVASESIQTWLLSDDGHIFTSSGNFVLDVSSGGYFVELVQLNSNSKTQIWTIDTTNNKIQNQGNGKYLDIDNLNICVAPLNGNATQQWTTFRRAPIPTGNWGYFQSKQMDSNNNYWGLSVLNNSKSYNTSVVMNKVQAKSKGQIWQMTNDGHILSRLDGSLVLDIGPSINGSTTNYYLDTNVYKANDLKQQWGINENNQIFNQYYPNLCIGFVGELGVDSTVNCVLAQPSSASDINFQWITNPTYSLNEIVSEVPEPFPAYTSGDLLASYQYLSNIATSNFTDDIRSLYTGINVSLQSFLSIVTNATCPSSIHSTEDFSNVQNQIKTELIYAIDVRLVFENYSGFYSKLFSQGSSNLTNLANLINVDMSSNQMVNANYTDAITSVFYSLISEIPVGGSIIANIGQSAVEWGELISQSNYQGASTYQVELSQLYSHLNTNYENEMANAQSMKDTILQDWGMMSKTYALCFLPTNDPSSLNINGLNFEKISDVASVAYEIAMIQMLLPTTYQIYFTPAGYWVPYSDGDFAYSDNSGTYIMATIEYSNSYPPKELTDKLWNNGVSKQEFFWSAYGWNLATSLTYYNMANKFGNIYKLAFPTIKNFTGVPMQFVMTNDGDNLCNFPVKTHFAKFFSIYYSCGDLGHHYFDIAVNDINDNKVANFTVDINLEAIEGSYVSIKTGSLVVQPGYAVGNPICNQGSYSLMFSASILIPIYKSE
What is the function of this protein?
May play an important role in stabilizing and/or regulating the cell membrane during Ca(2+) stress or certain stages of development.
What are the official names of this protein?
Calcium up-regulated protein B.
What is the protein family that this protein belongs to?
Belongs to the cup family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Associates with the cell membrane during Ca(2+) stress and cell aggregation.
Protein: WHIA_HALH5
Sequence: MSFAATTKKELTQLETDLCCSKAELAALIRMNGSLSFVNKQLGLDVTTENAAIARRIYTLIKKVFPMMFVELLVRKKMRLKKNNVYLVRLKQEAETLLKELKIIGEGFQIHRTISTDIVSATCCRRAYLRGAFLAGGSINHPETSSYHLEIFSLYEEHNESLCELMNSFQLNAKKLERKKGFITYIKESEKITEFLNIIGAHQALLYFEDVRIMKDMRNSVNRLVNCETANLNKTVGAALRQVENIKFLDQEIGLDALPTKLREIAELRLKHQDVTLKELGEMVESGKVSKSGVNHRLRKIDELAEKLRAGVPAESSSPR
What is the function of this protein?
Involved in cell division and chromosome segregation.
What are the official names of this protein?
Probable cell division protein WhiA.
What is the protein family that this protein belongs to?
Belongs to the WhiA family.
Protein: SPT22_BOVIN
Sequence: MKRNLNENSTRSTAGCLPVPLFNQKKRNRQPLTSNPCTNDPGISNASDNYDFPPLPSDWAWEAVNPELPPLTKTVNTGQIPHSVSNSLRSQDSLSKPIQSNAGSSKSDWSYRDGNKNTSLKTWDKNDFKPQCKRRNLMTNNGINSGPINLGAQQQKQLRVSESTNLPNQRESEALRQTKSSEIPGSTMRSLDKNSTLQAFKPNFQQNQFKKKMLDGFQEVNTLKKEASSYQLKLREKDNSLRIISAVIESMKYWREHVQKTVLLFEILAVLDSAVRPGPYCSKTFLMRDGKHTLPCVFYEIDRELPRLIRGRVHRCVGNYDQKKNIFKCVSVRPASASEQKTFQAFVKIVDAEMRYYTSVMNEV
What is the function of this protein?
Meiosis-specific protein required for homologous recombination in meiosis I.
What are the official names of this protein?
Spermatogenesis-associated protein 22.
What are the subcellular locations of this protein?
Chromosome. Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB.
Protein: RPRM_BOVIN
Sequence: MNPALGNQTDVAGLFLANSSEALERAMRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY
What is the function of this protein?
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle.  Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
What are the official names of this protein?
Protein reprimo.
What is the protein family that this protein belongs to?
Belongs to the reprimo family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Single-pass membrane protein.
Protein: PURA_COREF
Sequence: MAAIVIVGAQWGDEGKGKATDILGGLVDYVVKPNGGNNAGHTVVVGGEKYELKLLPAGVLSETATPILGNGVVINLEALFEEIDGLEARGADASRLRISANAHLVAPYHQIMDRVQERFLGKRAIGTTGRGIGPTYQDKVGRVGIRVQDIFDESILRQKIESALDVKNQVLVKMYNRKAIVAEETVQYFLSYADRLRPMVIDATLELNKALDEGKHVLMEGGQATMLDVDHGTYPFVTSSNPTAGGACVGSGVGPTRITSTLGIIKAYTTRVGAGPFPTELFDKWGEYLQTVGGEVGVNTGRKRRCGWYDSVIARYASRVNGFTDYFLTKLDVLTGIGEIPICVAYEVDGVRHDEMPMTQSDFHHAKPIFETMPAWDEDITGCRTFEELPQKAQDYVRRLEELSGARFSYIGVGPGRDQTIVLHDVMES
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14E_SULIL
Sequence: MPAIEVGRICVKVKGREAGSKCVIVDIIDDNFVLVTGPKDISGVKRRRVNILHLEPTDKKIDIQKGASDEEVRKKIEEAGLTEYMKERIKIKIPTL
What are the official names of this protein?
50S ribosomal protein L14e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL14 family.
Protein: NU3C_PROM2
Sequence: MFLLSGYEYFLGFLLIAAAVPILALVTNLIVAPKGRNGERKLTYESGMEPIGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFNRLGLLAFIEALIFIAILVIALAYAWRKGALEWS
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.  Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 3, NAD(P)H dehydrogenase subunit 3, NADH-plastoquinone oxidoreductase subunit 3, NDH-1 subunit 3, NDH-C.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.
Protein: CESS_CONGE
Sequence: MTRSAMQMGRLTLVLCLLLLLLLTTQACFIRNCPKGGKRDVDERYLFKACMSCSFGQCVGPRICCGPRGCEMGTAEANRCIEEDEDPIPCQVVGQHCDLNNPGNIHGNCVANGICCVDDTCTIHTGCL
What is the function of this protein?
Targets vasopressin-oxytocin related receptors (PubMed:32155768).  Is more active on fish receptors than on their human counterparts, supporting an evolved role of this conopressin in the envenomation process (PubMed:32155768).  Acts as an agonist on zebrafish vasopressin receptors V1a1R (EC(50)=10. 6 nM), V1a2R (EC(50)=44. 06 nM, partial agonist), V2R (EC(50)=299. 2 nM) and oxytocin receptor (EC(50)=353. 73 nM, partial agonist) (PubMed:32155768).  Shows a weaker activity on human receptors AVPR1B (EC(50)=51. 92 nM), AVPR1A (EC(50)=123. 78 nM), AVPR2 (EC(50)=299. 2 nM) and oxytocin (OXTR) receptor (EC(50)=455. 66 nM, partial agonist).  In vivo, exhibits grooming and scratching behavior in mice, following intracerebral injection (PubMed:3680228).
What are the official names of this protein?
Conopressin-conophysin.
What is the protein family that this protein belongs to?
Belongs to the vasopressin/oxytocin family.
What are the subcellular locations of this protein?
Secreted.
Protein: VP2_RHDV3
Sequence: MAFLMSEFIGLGLAGAGVLSNALLRRQELQLQKQALENGLVLKADQLGRLGFNPNEVKNVIVGNSFSSNVRLSNMHNDASVVNAYNVYNPASNGIRKKIKSLNNSVKIYNTTGESSV
What is the function of this protein?
Minor structural protein present in one or two copies per virion.  Does not seem to play a role in capsid assembly, but is essential for production of infectious virus (By similarity).
What are the official names of this protein?
Protein VP2, Minor capsid protein.
What is the protein family that this protein belongs to?
Belongs to the lagovirus VP2 protein family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: NHAA1_KINRD
Sequence: MPSAPQRPLFSRGSWPEARRLADVLRQETTGGLLLLVFTVIALVWANVAGNSYEEVRQFHLGPAALHLDLSIEHWAADGLLAIFFFVTGLELKKEFVAGDLRSPRAAALPIAAAVGGMAVPALLFVLVNVLHPDSPEGALVGWATPTATDIAFALGILAVVGSHLPSALRTFLLTLAVVDDLLGITVIAIFYTEQVHWTPLLLALLTLAAFTVAVQRRVRSWWLLVPLALATWALVHASGIHATVAGVLLGLVVPVLRSEEHGGPEAGPGLSEHFEHRWRPLSTGFAVPVFALFSAGVAIGGVSGFTAAVQDPVALGVIAGLVLGKPIGIVGTTWLLAKLTRAELDENLRWVDVLGMAMLAGMGFTVSLLIGSLAFGEGTAAGEHVTLGVLVGSLLSAVLAAVVLSRRNRVYRRIEAEERVDADGNGVPDVYER
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA 1, Sodium/proton antiporter NhaA 1.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SSRP_BACP2
Sequence: MPKGEGKVVSQNKKANHDYFIEETYEAGLVLQGTEIKSIRAGKVNLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLLHRKQISKLIGATKEEGYSLVPLKLYLKNGFAKVLIGIGKGKKKYDKREDLKKKDAKREIERAFRDRQKQF
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: YLAC_ECOLI
Sequence: MTEIQRLLTETIESLNTREKRDNKPRFSISFIRKHPGLFIGMYVAFFATLAVMLQSETLSGSVWLLVVLFILLNGFFFFDVYPRYRYEDIDVLDFRVCYNGEWYNTRFVPAALVEAILNSPRVADVHKEQLQKMIVRKGELSFYDIFTLARAESTS
What are the official names of this protein?
Inner membrane protein YlaC.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NFI1L_DANRE
Sequence: MAEPSGRYQQLPCEEEPEAGPQVAADAPPPYSSIAADSAAFFDYKDDAAFPNPPSYNVATSLPSYDEAERTKTETSVPLVSGRDDDFVARDDFEDADQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKWILIVRFSTYFPGYFDGQYWLWWVFLVLGFLLFLRGFINYAKIRKMADSFSTLPRTRVLFIY
What is the function of this protein?
May play a role in Golgi structure maintenance.
What are the official names of this protein?
NEDD4 family-interacting protein 1-like.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi- pass membrane protein.
Protein: NUCB1_HUMAN
Sequence: MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL
What is the function of this protein?
Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity).  Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity).
What are the official names of this protein?
Nucleobindin-1, CALNUC.
What is the protein family that this protein belongs to?
Belongs to the nucleobindin family.
What are the subcellular locations of this protein?
Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side. Cytoplasm. Secreted. Note=A small fraction of the protein may be cytoplasmic.
Protein: RL331_MYCTA
Sequence: MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLELKKFCPNCGKHQAHRETR
What are the official names of this protein?
50S ribosomal protein L33 1.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: TATB_SODGM
Sequence: MFDIGFGELMLLFVIGLVVLGPERLPVAVRTVTGWIRAIRSMASTVQNELTQELKLQELQDSLKKVEEASKNNLSPELKASMEELREAAESMKKYFKGINSAALDPTEPHTIHNPLVTDPEALHDGVTPAEGDRQAEAPLMAPSVKASAPADSVANPGEPIAAAAIGQPAAASVDAASTSPSAKVSAPADSAANLATQAATPAAPAPAPEEPGRAATATGPASSTSPLNNDR
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides.  TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
What are the official names of this protein?
Sec-independent protein translocase protein TatB.
What is the protein family that this protein belongs to?
Belongs to the TatB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ILVC_ANADE
Sequence: MATIYYDKDANLDLLKKRKVAIIGYGSQGHAHALNLRDSGVDVRVGLAAGSKSKAKAEGAGLRVLSVAEASKEADVIMVLIPDQTQKKVYDEEIAPHLSKGKALLFAHGFNIHFVQVRPPPDVDVLLVAPKGPGHMVRRQYQDGRGIPGLVAVHQDATGQAKAVGLAYARGIGCTRAGVLETTFKEETETDLFGEQAVLCGGAAALVKNGFEVLVEAGYQPESAYFECLHELKLIVDLMYEGGLAWMRHSISDTAEYGDYTRGPRVVDGRSKDEMRKILKEIQGGHFAKEFILENQAGGPTMARYRAAEAAHPIEEVGKRLRDMMSWIREAKKDSSDPGSR
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: BIOB_FRAAA
Sequence: MTAHIAPATVPPSAPAAAGQDPAALLAHARREVLEAGRGLDEAGVLAVLRLPDEYLGDALALAHEVRMRWCGPEVEVEGIISLKTGGCPEDCHFCSQSGKFDSPVRSAWLDVPSLVEAARQTAATGATEFCIVAAVRGPDARLMSQVREGVAAIRAAVDINVACSLGMLTQDQVDELTAIGVHRYNHNLETSRSHFPKVVTTHSWEERWETCEMVRAAGMELCCGAILGVGESLEQRAELAAQLAVLEPDEVPLNFLNPRPGTPFGDYPPVQPRDALRAIAAFRLALPRTILRYSGGREITLGDLEAQGMLGGINAVIVGNYLTTLGRPAESDLKMLADLSMPIKSLQATL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.