PharMolix/UniProtQA huggingface dataset:
Protein: LIPB_ALBFT
Sequence: MAMDLLRHRLGRIDYLPAYEAMQVFTAARTPETPDELWICEHPPVYTQGLAGKAEHVFNPGTIPVVQTNRGGQVTYHGPGQVVAYPLLDLKRAGYFIKEYVYRIEEAVIRTLVEFGVTGHRVAGAPGIYVRLDDPGSHALLPQRPMKSGLANPSFGGLGKIAALGLKVSRNCTYHGVALNVAMDLEPYTRINPCGYAGLQTVDLSTIGVCAGWDEVAELLGDKLTRYLAP
What is the function of this protein?
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes.  Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
What are the official names of this protein?
Octanoyltransferase, Lipoate-protein ligase B, Lipoyl/octanoyl transferase, Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase.
What is the protein family that this protein belongs to?
Belongs to the LipB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_SYMTH
Sequence: MAELVSVAILGYLLGSIPVGFLMGKLRGIDVRRYGSGATGGTNVLRTLGPWAALFTVLCDIGKGLLAAYLGERLAGEWGFVAAGLLASLGHSYPVWLRFRGGKSVATSGGVMLLHYPLAVLVGIAAGALAVVPTRWVSLGSLTASLAVVLQLFLLDAPLSHRLLVVALAVVIYVRHWENMKRIAAGTENRLGVKARPRA
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: NCAP_I76AE
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWMRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYEFEREGYSLVGIDPFRLLQNSQVFSLIRPKENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQLSTRGVQIASNENMEAMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMESARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: RS18_SHESM
Sequence: MARYFRRRKFCRFTAEGVAEIDYKDIVTLKNYITESGKIVPSRITGTSAKYQRQLARAIKRARYLSLLPYTDLHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: PRM1_YEAS7
Sequence: MSGFKCYLQLGDRLSQIWLNKYTLVLLLAMLKLLFFSKSIQHAIEVSETYILSNCYSIDSLYSKMTDNTPHYLGIMGNYLIEKGMEETVKATLETLSLIVYASEGLVNFAIDLYLGTYACLIVSAVDGTVDVATNTTEKLISLVNDTVSSVANELDTGLNDISKIINKVIKAASKVENFFTGDDDDSNMTSSIKSVNLTISALHNLYIPSSINDKLEELSAKTPDFAQVKNTTKNLISVPFNEVRKNIKAVNASNIIGDTSVLYVPPVSLDNSTGICSSNQSEILAFYSILGQVLKIATVVCITVLICFAVGAMAPVAWNEIKLWRRLCGMRDHYMLSRQDSYTSFSSENTHELKDPFRDPPIQNGQYDVIASYQQCFQTWNTRIAGWMTNLVTFGKSPENIDPKTKQKIEWVVAYMTSERALCVLGIGLLGILVCICQFVMIALLKHKISHSLTSNDGDGVQNLLKSSTAVDIENQMSLWSVQTNKYINTTETNINQEVFGWINTTTLSVNNTVATMISDIDTTLADVFNGTLLYNPMKTVVGCAIENKLYTIEKAMTWIHDKAQLHIPRINGTQIKQALAKQADNSTIPTASSTSAATENLLENLVNDMREGLLKILRAYHRITLGELTVALVILAVWLVQLPIALVILRLRLRKATFD
What is the function of this protein?
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
What are the official names of this protein?
Plasma membrane fusion protein PRM1, Pheromone-regulated membrane protein 1.
What is the protein family that this protein belongs to?
Belongs to the PRM1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Localizes at sites of cell fusion during mating.
Protein: Y085_OSHVF
Sequence: MSFYRGRINKGSGLFKSFPSNGEYIKKITPGIGEYFYKKHKFSGDSGLKQLSAQAWRDKLDEDDLLEYGSATYNASLPGDIIRRFFYFQFYNNVVTHPLLDLISIRRDHEAPFSDRNESKIKLDPAKRLPLGLRLADVFARWFDIYDLGWLKTLWNTYSDTGLSEIHRTYDIIFVHIVNRVAKVNPELMNFRTGDYDEILRCMRAIHAFAVLTDDVYDLYEKELIEPIRDRYEEILSAYMEEDDIPHYGLWDTVYYEGYTNLLEYVNLLIGDQTRASDTRQLSMPLITDICHLLKYIDINKGSYYRLERMLNRVDKVEKESPSYDNNIPTTRSERKKRRVGPIITTDRVYNYKGSWVDPQDDMYVVYDALRRKYKTMFFTQNTIEITTIERVSERYSLDFIERDDDGVGMTDTIKTILEDHRFNTLMKEVSKSDNTLNMLVNGNVEPVECKFASITMGEDDSVLESVNLELTVSDKYYLDDAMVFYIYVYNTLTNKNIPTAATLETLRDGPFSKPVPLKVKDVIDGYMQKHHGLGVISEKYTVEDYLLICLSDLYERDVPKFLDIYLQNRRDGYEIAENIKAILILLTSPAVSKYVYRKLMGDLLTDEDAIQYAGRAEVVTELSGVVKGNRELGFVNRYIKQGIYRASPYNVFKTDLEYLLSVLADE
What are the official names of this protein?
Uncharacterized protein ORF85.
Protein: SKI8_HUMAN
Sequence: MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCPI
What is the function of this protein?
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.  PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.  PAF1C is required for transcription of Hox and Wnt target genes.  PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.  PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3).  PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription.  PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors.  In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription.  Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3).  Required for Hox gene transcription (PubMed:16307923, PubMed:19952111, PubMed:20178742).  Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C (PubMed:16024656).
What are the official names of this protein?
SKI8 subunit of superkiller complex protein, Meiotic recombination REC14 protein homolog, SKI8 homolog, Ski8, WD repeat-containing protein 61.
Protein: UCK1B_XENLA
Sequence: MASAGSLDVPERGHQRPFLIGVSGGTASGKSTVCEKIMELLGQNEVDHRQRKVVILSQDRFYKVLTPEQKARALKGQYNFDHPDAFDNELMDRTLTQILDGQIVAVPMYDFITHSRLPETTTVYPADVVLFEGILAFYNQEIRDMFQLKLFVDTDSDVRLSRRVLRDMKRGRDLEQILTQYTTFVKPAFEEFSLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWQRGVQNGRSQKRTLPGQGDSGGLLLQGKRTHLESSSRPH
What is the function of this protein?
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate.  Does not phosphorylate deoxyribonucleosides or purine ribonucleosides.  Can use ATP or GTP as a phosphate donor.
What are the official names of this protein?
Uridine-cytidine kinase 1-B, UCK 1-B, Cytidine monophosphokinase 1-B, Uridine monophosphokinase 1-B.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
Protein: SYME_ECO55
Sequence: MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESELMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
What is the function of this protein?
Involved in the degradation and recycling of damaged RNA.  It is itself a target for degradation by the ATP-dependent protease Lon.
What are the official names of this protein?
Endoribonuclease SymE.
What is the protein family that this protein belongs to?
Belongs to the SymE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAC1_ARTBC
Sequence: MKRLGLAALYIGSALAWPEPHGPPSRNVPRDDFPMFNPLPSTDLNTRLIRCEYPSMKGWTYSNKKNGDWLKYVGSKPGEITEYNIDTDNDKYVPQGITRKYHLEVTDESVNMDGTMFDQAKVFNKQYPGPWIQITVTNKLKHNGTAIHWHGIRMMENMFNDGVPGVTQCPIPPGSSMTYRFKASQYGSSWYHSHYSLQYADGLFGPMTIHGPTSAGYDKAVDPLLMTDHLHSSAFEEYHKELEGKPPAMDSIILNGKGDYDQTGDLKKKYRTVLKPGKKYLLRLINTSVATTFVFSIDGHKFQVVGSDFVPIEPYVTDHIAVGIGQRYHVILEGLSEEEAKKNGRYWVRTTPAKGCSKFAPGRGTDDRTGVIYYNKDDGVSPTTEIGAFSLDCRDEPLEKLVPKVKWTVPDPGLNMVGAFEKPADVQLGKWHRPGYPDTDNLVSNWEFGPSPMWINYSEPIIKNLDKDSFPSTWVVYPADDYVNDKWVYLVITGKKLKPLSSQVAVAHPIHLHGHDFVLLQQSMEPWDSTEVNLKLDNPPRREVTLLPAGGFIVIAFKPDNPGSWLLHCHIAWHASAGLALQVLERKEDLKALTLNNPDFDFMQENCRKWDAWHSDKTNYWNPSGHFQDDSGV
What are the official names of this protein?
Laccase ARB_05828, Benzenediol:oxygen oxidoreductase ARB_05828, Diphenol oxidase ARB_05828, Urishiol oxidase ARB_05828.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Secreted.
Protein: CLP1_DROPE
Sequence: MSDHQSRGQDFSLEADSELRFEIEQKDAKVLVTLVNGFAELFGTELVKKKKYEFGMGAKVAIFTYQGCVLHVTGKMDVCYISKETPMVQYVNCHAALEQFRTEAEEKDRRGPVAMVVGPTDVGKSTLCRILLNYAVRVGRRPLYADLDVGQGAIAISGNVATILIERPASVEEGFPKTAPLVYHFGHKSPSGNSVLYNAVVSKMAEVTLQSLNGNKRTKSSGIIVNTCGWVKGHGYAHLLHAARAYGACAIFVLDQERLYNELLRDVPSSVHVVLLPKSGGVVERSKELRHECRDQRIKEYFYGNARAPFYPFSFEVKFQELRLYKIGAPPLPDSCMPIGMKAEDNKTKVVAVTPTPALIHHVLALSFAESVDDDVIGTNIAGFCCVTEVDMERQVVMLLSPQPRPLPPNALLLWSELQFMDNHT
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
Protein CLP1 homolog.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y1362_LACH4
Sequence: MNLGLAIFLIIIALLVGAVAGFYGARAYMKKYFKENPPISEDMIVAMMSQMGQKPSNKKVHQVMNMMKHQQK
What are the official names of this protein?
UPF0154 protein lhv_1362.
What is the protein family that this protein belongs to?
Belongs to the UPF0154 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: Y523_STRZT
Sequence: MEIKFTIKQVVAVGIGAALFVVIGMINIPTPVPNTSIQLQYAVQALLSIIFGPIIGLLVGLIGHAIKDSLVGYGLWWTWIIASGLFGLVVGLFRKYVRVINGVFDWKDILIFNLIQLLANALVWGVLAPLGDVVIYQEAAEKVFAQGIVAGIANGVSVAIAGTLLLLAYAGTQTRAGSLKKD
What are the official names of this protein?
UPF0397 protein SPT_0523.
What is the protein family that this protein belongs to?
Belongs to the UPF0397 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2580_AERPE
Sequence: MRRIGLEALERVLYPVIPVVVTAEHQGRVGGMLAAWWMQASFTPPILAVAIAPERYTYKLVRESGVFAFNLLDFKLVDKAPFLGDVSERLLPGKIREAGLNIVRGEVLGAPLIAEASAAVELELVDVVEAGDHDVFLGEAKAVYTVDDFRGGMWSLETYRPLMYLGRTRRPGPVYRVYLTPRGWERREIEFAGGKLKPLAEKRVRLISRVEEAVKASSSREEAVDAVRRILSEEGLDPSDAEYLVEDALRRAKSYRRRGQSSS
What are the official names of this protein?
Uncharacterized protein APE_2580.
What is the protein family that this protein belongs to?
Belongs to the flavoredoxin family.
Protein: PF36_PLAYO
Sequence: MRKALYSLLFYMCICLYIYTPVFMANLKEIEVGNYFICNLRDYPTGNCSVDHDYNKTIKLLCPIVNNKNNSNKTYDPSYCFKYDGIKDEFIINNKQAYIHNTLPGVILTNNIENDTYNLSIYPPFVVKEDVTIVCICDSEKGNEGITPYLKINIKKTHGLNNDLEGDYIKGCDYGNNQGKYKFLTKPVKYTSNPICEIDAYPGDVVGINCNSYTTKMQGARLEPEGCFAMVYFSILTMKFIKTNVNNIMPNAKYYPDLASHPGNQNSKIFLTSYLLIPNEVDRDILIYCNCSYNGNKGLAIYRIFSTKAS
What is the function of this protein?
Involved in sporozoite infection of hepatocytes and replication therein.
What are the official names of this protein?
Sporozoite surface protein P36.
What are the subcellular locations of this protein?
Cell surface. Cell membrane. Note=Present on the surface of sporozoite.
Protein: TPS1_PHYDL
Sequence: MALAKESSIVVSSSPDVTHNITRPVASYHPNVWGDRFLLSSSDQVQLTMKARDDKVVVDELKKEVRRKLKEASNDYIRLLQTVDVIQRLGLAYHFEEEIDQALRYLFETFHDYSEDSQDMYANSLSFRLLRQHGYRISCEIFEKFKDANGGFKIPNIEGVMGMLEFYEATHLRVRGEDILDHGFVFSRNYLKSVLPSLSNPLAAQVDRALNQNSNRRGLPRLEARHFMSVYEQYASHDQALLKLAKLNFNILQSLHKVELSEISRWWKGVDIARNFPYARDRIVELYFWVLGVYFEPQYAVGRKITTKVIAIASLLDDTFDAYGTFEELRIFAEAVERWSVSCLDQLPEYMKLLYKTMLEVSDEIEEEMTKLGTPFRIAYGIEAIKTFARSYFLEAKWREEKYKPTTEEYMGLATKTCGYKSLIITSFLAMGDIPKREHFDWVLSDPDFVMASCIICRLADDIVGHEFEQTRDHIPSSVECYTQEHKTSKEDAVNELYDRLESAWKDLNEGFLRPTKIPAALLYRVLNYCRIIEVMYSRGDWYTHVGPEMQGFVRQLLVDPVPE
What is the function of this protein?
Sesquiterpene synthase converting farnesyl diphosphate to alpha copaene and delta-cadinene as the major products.
What are the official names of this protein?
Bifunctional sesquiterpene synthase 1, Alpha-copaene synthase, Delta-cadinene synthase, Terpene synthase 1, LdTPS1.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: ITK_HUMAN
Sequence: MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAESGL
What is the function of this protein?
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response.  Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells.  When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK.  Phosphorylation leads to ITK autophosphorylation and full activation.  Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates.  In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty.  Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2.  Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281).  Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity).  Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase ITK/TSK, Interleukin-2-inducible T-cell kinase, IL-2-inducible T-cell kinase, Kinase EMT, T-cell-specific kinase, Tyrosine-protein kinase Lyk.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Protein: UL16P_HCMVA
Sequence: MERRRGTVPLGWVFFVLCLSASSSCAVDLGSKSSNSTCRLNVTELASIHPGETWTLHGMCISICYYENVTEDEIIGVAFTWQHNESVVDLWLYQNDTVIRNFSDITTNILQDGLKMRTVPVTKLYTSRMVTNLTVGRYDCLRCENGTTKIIERLYVRLGSLYPRPPGSGLAKHPSVSADEELSATLARDIVLVSAITLFFFLLALRIPQRLCQRLRIRLPHRYQRLRTED
What is the function of this protein?
Plays a role in escape from host immune response.  Blocks the interaction between the host KLRK1 receptor with the ligands ULBP1 and ULBP2.  ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines.  The sequestration of diverse KLRK1 ligands in the endoplasmic reticulum and cis-Golgi apparatus of cells by UL16 inhibits the activation of NK cells.
What are the official names of this protein?
Protein UL16.
What is the protein family that this protein belongs to?
Belongs to the HHV-5 UL16 protein family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein.
Protein: GCS2_ECO7I
Sequence: MPLPDFHVSEPFTLGIELEMQVVNPPSYDLSQDSSMLIDAVKNKITVGEVKHDITESMLELATDVCRDINQAAGQFSAMQKVVLQAAADHHLEICGGGTHPFQKWQRQEVCDNERYQRTLENFGYLIQQATVFGQHVHVGCASGDDAIYLLHGLSRFVPHFIALSAASPYMQGTDTRFASSRPNIFSAFPDNGPMPWVSNWQQFEALFRCLSYTTMIDSIKDLHWDIRPSPHFGTVEVRVMDTPLTLSHAVNMAGLIQATAHWLLTERPFKHQEKDYLLYKFNRFQACRYGLEGVITDPHTGDRRPLTEDTLRLLEKIAPSAHKMGASSAIEALHRQVVSGLNEAQLMRDFVADGGSLIGLVKKHCEIWAGD
What is the function of this protein?
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
What are the official names of this protein?
Putative glutamate--cysteine ligase 2, Gamma-glutamylcysteine synthetase 2, GCS 2, Gamma-GCS 2.
What is the protein family that this protein belongs to?
Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
Protein: EDEM3_HUMAN
Sequence: MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
What is the function of this protein?
Involved in endoplasmic reticulum-associated degradation (ERAD).  Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans (PubMed:25092655).  May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952).  May have alpha 1,2-mannosidase activity (By similarity).
What are the official names of this protein?
ER degradation-enhancing alpha-mannosidase-like protein 3, Alpha-1,2-mannosidase EDEM3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
Protein: TSAD_CLOBH
Sequence: MKESINILAIESSCDETSAAVVVNGREVLSNIIASQISTHEKFGGVVPEVASRKHIEVISAVVQEALDEANFTLDDIDAIGVTYGPGLVGALLVGLQYAKGLAFATGKPLIGVNHIEGHISANFIEYKDLKPPFMCLVVSGGHTFIVYMKDYGEFEVLGETRDDAAGEAFDKVARAIGLGYPGGPKIDKISKEGNEEAIKFPRANFHNDTLDFSFSGIKSAVLNYLNKKEMKGEEINKADVAASFQKSVVDVLVDNTIKACMSKKVDKIAVAGGVASNSCLRETLVRECKKKGIEVLIPPFILCTDNAAMIGSAAYFEYIKGRRTSLDINAVPNLKLGER
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MQO_ECOBW
Sequence: MKKVTAMLFSMAVGLNAVSMAAKAKASEEQETDVLLIGGGIMSATLGTYLRELEPEWSMTMVERLEGVAQESSNGWNNAGTGHSALMELNYTPQNADGSISIEKAVAINEAFQISRQFWAHQVERGVLRTPRSFINTVPHMSFVWGEDNVNFLRARYAALQQSSLFRGMRYSEDHAQIKEWAPLVMEGRDPQQKVAATRTEIGTDVNYGEITRQLIASLQKKSNFSLQLSSEVRALKRNDDNTWTVTVADLKNGTAQNIRAKFVFIGAGGAALKLLQESGIPEAKDYAGFPVGGQFLVSENPDVVNHHLAKVYGKASVGAPPMSVPHIDTRVLDGKRVVLFGPFATFSTKFLKNGSLWDLMSSTTTSNVMPMMHVGLDNFDLVKYLVSQVMLSEEDRFEALKEYYPQAKKEDWRLWQAGQRVQIIKRDAEKGGVLRLGTEVVSDQQGTIAALLGASPGASTAAPIMLNLLEKVFGDRVSSPQWQATLKAIVPSYGRKLNGDVAATERELQYTSEVLGLNYDKPQAADSTPKPQLKPQPVQKEVADIAL
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: TAGU_BACAA
Sequence: MKKKILFWVLGILGVLIIGGGIYAYNVYSSVSNTLKEVHQPLKRDQNNSNVGEKVSKSEPVSILLLGADERGEDKGRSDSLMVITLNPKNNSMKTVSIPRDTYTEIVGKGKSDKINHAYAFGGVDMSVATVENFLNVPINYYIEVNMEGFKDIVDAVGGVDVKNDLEFTQDGHHFAKGNIHLTGDQALAFTRMRKQDPRGDFGRQMRQRQVMQGVIKKGASFSSLTGYGDVLSAIQKNVKTNLTQDQMFDMQKNYKDCLKNSEDIQIPGDGHKAADGIWYYYVPDAAKQDLTNKLRTHLEVTK
What is the function of this protein?
May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG).
What are the official names of this protein?
Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagU.
What is the protein family that this protein belongs to?
Belongs to the LytR/CpsA/Psr (LCP) family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: DAD3_ASHGO
Sequence: MSDALSTLQRSVLEKYRTLADCLHELNDTLVELNTDSDTNPEQVLAQMREIEVKIALVGTLLKGSVYSLVLQRNMGKQAPGGKAK
What is the function of this protein?
Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.  The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).
What are the official names of this protein?
DASH complex subunit DAD3, Outer kinetochore protein DAD3.
What is the protein family that this protein belongs to?
Belongs to the DASH complex DAD3 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Associates with the mitotic spindle and the kinetochore.