PharMolix/UniProtQA huggingface dataset:
Protein: SYS_GLOVI
Sequence: MLDPKLLRDDPAKLIERLNTRGGDFTEVIEQLVALDSQRRASQTAFNRAQAEGNQIGKQVGERLRRGTAVGDPEVLALKQRGIDLKATLALLQDQERELAERFAALLPTLPNVPRPEVPIGKDENDNREMRFWGTPPIFDFEPAAHWDLGERLGLMNFARATLVAQARFVTLMGDGALLERALIAFMLDRHRAHGYIEILPPYLVNTASMTGTGQLPKFAEDSFRCRDDDLWLIPTAEVPVTNLYRDEILTDMQLPIHHCAFTPCFRREAGSYGRDTRGLIRLHQFHKVELVKFCRPEHSPTEHEKLVADAEDVLQQLELPYRVIELCTGDLGFGAARCFDLEVWLPSQNRYREISSCSNFEDFQARRANLRFKAPDKKGTEFVHTLNGSGLAVGRTFAAILENYQNRDGTVRVPEALKPYVRRDVLSR
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERA_BRUME
Sequence: MNNGTSPAGGETEATQTRSGFVALIGAPNAGKSTLVNQLVGTKVSIVTHKVQTTRALVRGIFIEGPAQIVLVDTPGIFRPKRRLDRAMVTTAWGGAKDADIILVIIDAQGGFNENAEALLESMKDVRQKKVLVLNKVDRVDPPVLLSLAQKANGLVPFDRTFMISALNGSGCKDLAKYLAESVPNGPWYYPEDQISDMPMRQLAAEITREKLYLRLHEELPYASTVETERWEERKDGSVRIEQVIYVERESQKKIVLGHKGETVKAIGQAARKEISEILEQTVHQFLFVKVRENWGNDPERYREMGLDFPT
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: PA1_KLEPN
Sequence: MRISLACLAALCALPAGVMAQDASVHDKPAVRGSIIANLLQDHDNPFLLYPYESNYLLYTWTSDLNKEAIRSYDWAENARKDEVKFQLSLAFPLWRGILGDNSLLGASYTQKSWWQLSNSKESAPFRETNYEPQLFLGFATDYQFAGWTLRDIEMGYNHDSNGRSDPTSRSWNRLYARLMAQNGNWLVEVKPWYVVGSTDDNPDITKYMGYYRLKVGYQLGEAILSAQGQYNWNTGYGGAELGVSYPITKHVRAYTQIYSGYGESLIDYNFNQTRVGVGLMLNDLF
What is the function of this protein?
Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3. 1. 1. 4) and phospholipase A1 (EC 3. 1. 1. 32) activities.
What are the official names of this protein?
Phospholipase A1, Detergent-resistant phospholipase A, DR-phospholipase A, Outer membrane phospholipase A, OM PLA, Phosphatidylcholine 1-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A1 family.
What are the subcellular locations of this protein?
Cell outer membrane; Multi-pass membrane protein. Note=One of the very few enzymes located there.
Protein: YHBP_ECOL6
Sequence: METLTAISRWLAKQHVVTWCVQQEGELWCANAFYLFDAQKVAFYILTEEKTRHAQMSGPQAAIAGTVNGQPKTVALIRGVQFKGEIRRLEGEESDLARKAYNRRFPVARMLSAPVWEIRLDEIKFTDNTLGFGKKLVWQR
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: ARC_RHOJR
Sequence: MSSTENPDSVAAARELEALRAEASALRRQLAESPEQLREMESRVDSLSIRNTKLMDTLKEARQQLIALREEVDRLGQPPSGYGVLLGVHDDQTVDVFTSGRKMRLTCSPNVDAETLKLGQTVRLNEALTIVEAGNFERVGEISTLREVLDDGQRALVVGHADEERIVWLAEPLATVYEDSERESIAYDAESPTRKLRPGDSLLVDTKAGYAFERIPKAEVEDLVLEEVPDVHYDDIGGLGRQIEQIRDAVELPFLHKDLFHEYELRPPKGVLLYGPPGCGKTLIAKAVANSLAKKIAEARGQDSKEAKSYFLNIKGPELLNKFVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGSGVSSDVETTVVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAESAQDIFSKYLVETLPVHSDDIAEFGGDRTACIRVMIERVVDRMYAESEENRFLEVTYANGDKEVLYFKDFNSGAMIQNIVDRAKKYAIKSVLDTGAPGLRVQHLFDSIVDEFSENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKNASASRAIDTESNTGQYL
What is the function of this protein?
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle.  May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis.  Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
What are the official names of this protein?
Proteasome-associated ATPase, AAA ATPase forming ring-shaped complexes, ARC, Proteasomal ATPase.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
Protein: PSBB_ANTAG
Sequence: MGLPWYRVHTVVLNDPGRLIAVHLMHTALVSGWAGSMALYELAVFDPSDPVLDPMWRQGMFVIPFMTRLGITKSWGGWSITGETVTNAGIWSYEGVAAVHIVLSGLLFLAAIWHWVYWDLELFRDERTGKPSLDLPKIFGIHLFLSGVLCFGFGAFHVTGLFGPGIWVSDPYGLTGKVEPVAPAWGAEGFDPFVPGGIASHHIAAGILGILAGLFHLSVRPPQRLYKGLRMGNVETVLSSSIAAVFFAAFVVAGTMWYGSAATPIELFGPTRYQWDQGFFQQEIDRRIRSSKAENLSLSEAWSKIPEKLAFYDYIGNNPAKGGLFRAGAMDNGDGIAVGWLGHAVFKDKEGHELFVRRMPTFFETFPVVLVDEEGIVRADIPFRRAESKYSVEQVGVIVEFYGGELDGVSFSDPVTVKKYARRAQLGEIFEFDRATLKSDGVFRSSPRGWFTFGHATFALLFFFGHIWHGARTLFRDVFAGIDSDLDAQVEFGAFEKLGDPTTKRQVV
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII.  PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
What are the official names of this protein?
Photosystem II CP47 reaction center protein, PSII 47 kDa protein, Protein CP-47.
What is the protein family that this protein belongs to?
Belongs to the PsbB/PsbC family. PsbB subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: RECR_HAHCH
Sequence: MSSSLTPAIDQLVRCLRYLPGVGAKTATRMALNLLERDQGRAADLAIAISDALTRVKRCSRCQNFCEAELCSICESPKRDDRVLCVVESPTDVLAIEQTSDYSGRYFVLMGHLSPIDGIGPEDIGVDKLKQLLQESAVSELILATNPTVEGEATAHFIAHIAKDLNIPVSRIAHGIPLGGELGMIDSGTLSHALQGRKPFA
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: ATG13_ASPFU
Sequence: MHQHPRSPAPAAPTSSTRSNRSTDHRELDTDPSSPSSDVRMHNGRGLGIEPETEPSEQVQRNTQPAKEAMAKLNQIITFNVEIEDTDILREQLRIWRTCDAIENRPPPLIIETYLETKGLTNNQSLVILDENGKRWDVLEALTASGQASPVRPPHSNSDDVILERWRVELGSASSKPPSDLGSILPTVYKKSIVLFRSLFTYSKFLPAWKFAKRNGRLRSNPALQIRYRILDGRTASDRRQVDHLTVPLYEGNTKVVETYSFGVTDSPAGPFSVEVTYRTNCDFRVDDSEALLSSRFMGADDEIFRPSFPSRDANRRASNAEPGSAPLEKRTVEEPDPGRAYGSLSTFHHVGPATGASPISALRAARESVTSSPSPPSSASRRPLSAARAAPTGRAAALAAEASPSPLRRPSISFQPFKAPPLSASPSLIDPPLGASPRSRPIVSAPSSEPKHMPPPSVAASGRKTGQAASENAIASSNSASPRPAPIARYSSAFSHRRGRPSSGGINKIEDDASSGKASATSSGAQPGSGLLAEVTGTSADSLHADDENISEFLKMLDLRKDLLSPSNLSNLDAVARRTTVTSAALTRFQRMRDSNAALSESMSSSLLLQRSSNASSKQLSGVPPMVAGASVSTASSPGKPISPHTPHTPAIPSRLSSNSIVDYNDHGHSDGRLLHGGPTSLPEDTTGEETALVHRPPTVTAIDIPTSPRLFPPTYRRSSSAAQNRRSVVADEEEIFPFNMRSVSLGAEERTNVSLSTLHRRHEYHNAATNPEQQQESQRASSSSDQGPTALPSPAKRETRSQGDATVSGQTPELSSSANHNLYQPRLGQFRSRGSFGGAHSLSSGSSSLARGGGIPTYLTERDNDRDGNASGSNSGNSTTEERRGFGRRVSAGRNYPPHPSQVEEDEPLLFAMSDFGASRRSFEEGRQGNHGADFGGSRRGSGRRGAGVPGFHVWS
What is the function of this protein?
Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy.  Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation.  Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy.  Finally, atg13 is also required for glycogen storage during stationary phase (By similarity).
What are the official names of this protein?
Autophagy-related protein 13.
What is the protein family that this protein belongs to?
Belongs to the ATG13 family. Fungi subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Preautophagosomal structure.
Protein: PXPA_BURCM
Sequence: MEIDLNADLGEGCGSDEALLDLVTSANIACGWHAGGANAMRDCVRWAVQKGVSIGAHPSFHDPENFGRKEMQLPAGDIYAGVLYQLGALSAIAQAEGGRIAHVKPHGALYNQAARDPLIADAVVSAIHDFDPSLAVFGLANSVFVAAARHAGLAAVEEVFADRGYRADGSLVPRSQPGALIDDENAVLARTLDMVRERKVRAVSGEWVPLNAQTVCLHGDGPHALAFAKRIRTALEAAGVDVVAPGALQADEDA
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: CCNL1_DANRE
Sequence: MSLGMLSPHLNTPPPNNQGILIGDKVYSEVFLAIDNSIIPEDRLSTTPSMLDGLDHETETDLRILGCERIQSAGILLRLPQVAMATGQVIFQRFFFSKSFVKHNFEIVAMACVNLASKIEESPRRVRDVINVFHHLKQGKGKKSTPLILDQNYINTKNQVIKAERRILKELGFCVHVKHPHKIIVMYLQVLECEKNQMLVQTAWNYMNDALRTSAFVRFEPETIACACIYLAARVLQIPLPSKPHWFLLFGATKEDIKEICINTMKLYSREKPHSEQLERQVEKRKIFLEEARLKARGQNPNGTPALASINGFSPASKPSSPRDVKMDDKSPNSKLKEPENRQLFAKSPLNGSIKKEDGKVFQNGKNHSRSRSRSTSRSPHRHRRSHSGTYSSHSSHSPSPRQKARRPSPISQLRTDRDRPSETSRHSNKRRRSRSRSRSNSRERVRDRDHIKHKQERSGSGHHWDHRDRERDRSRDHGRNKRQSRSHSGHSHSRHRR
What is the function of this protein?
Involved in pre-mRNA splicing.
What are the official names of this protein?
Cyclin-L1.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin L subfamily.
What are the subcellular locations of this protein?
Nucleus speckle. Nucleus, nucleoplasm. Note=Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
Protein: SPXH_STAA8
Sequence: MAGELRIMENKSREDINLSPVSKIEIYSFFDPFSSDCFKLSAILSKLRIEYNQYIRIRHILNPSLKVLTKCQAQSTSNFDNIALAYKAAELQGRVRAERFIHLMQNEIIPKRDIITESMICDCIQNAGIDLEVFKDDLQKSKLTESLKIDLHIAREMEIEQAPSLVFFSEDVHEEGLKVEGLYPYHIYTYIINELMGKPIEKNLPPKLETYIQQQQLVTMEELLTIYEWPEKLLNKELKKLAIQQKIEKLKYPDGDFWKSKMPKIKSK
What is the function of this protein?
Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions (PubMed:22194450, PubMed:32117138).  Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP (By similarity).  Involved in disulfide stress regulation (PubMed:21947404).
What are the official names of this protein?
ClpXP adapter protein SpxH.
What is the protein family that this protein belongs to?
Belongs to the SpxH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SDH31_ORYSJ
Sequence: MEKYHSNSRFAPFRDAPFALRGALGSSGSSFSSIDSLRRSSTLEQARGYTSRPLGAVRPKMLPSGCRPLHTSHPLSAPVANRPLSPHLPLKKPQLSATFSISHRIFGAALGAAIISIPLATKFSLMFDV
What is the function of this protein?
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
What are the official names of this protein?
Succinate dehydrogenase subunit 3-1, mitochondrial.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: PDLI2_MOUSE
Sequence: MALTVDVAGPAPWGFRISGGRDFHTPIIVTKVTERGKAEAADLRPGDIIVAINGQSAENMLHAEAQSKIRQSASPLRLQLDRSQTASPGQTNGEGSLEVLATRFQGSLRTHRDSQSSQRSACFSPVSLSPRPCSPFSTPPPTSPVALSKEDMIGCSFQSLTHSPGLAAAHHLTYPGHPTSQQAGHSSPSDSAVRVLLHSPGRPSSPRFSSLDLEEDSEVFKMLQENRQGRAAPRQSSSFRLLQEALEAEERGGTPAFVPSSLSSQASLPTSRALATPPKLHTCEKCSVNISNQAVRIQEGRYRHPGCYTCADCGLNLKMRGHFWVGNELYCEKHARQRYSMPGTLNSRA
What is the function of this protein?
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment.  Necessary for the migratory capacity of epithelial cells.  Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth.  May contribute to tumor cell migratory capacity (By similarity).
What are the official names of this protein?
PDZ and LIM domain protein 2, PDZ-LIM protein mystique.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes at the cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN) (By similarity).
Protein: Y283_CROS8
Sequence: MERFIENAMYASRWLLAPVYFGLSLALLALTVKFFQEIIHVLPNILTIAEADLILLLLSLVDMTLVGGLLVMVMFSGYENFVSQLDIHEGKEKLSWLGKMDASSLKNKVAASIVAISSIHLLRVFMDAKNVPDNKLMWYVIIHLTFVLSAFVMGYLDKISRSKGY
What are the official names of this protein?
UPF0114 protein ESA_00283.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ATL16_ARATH
Sequence: MDLSNRRNPLRDLSFPPPPPPPIFHRASSTGTSFPILAVAVIGILATAFLLVSYYVFVIKCCLNWHRIDILGRFSLSRRRRNDQDPLMVYSPELRSRGLDESVIRAIPIFKFKKRYDQNDGVFTGEGEEEEEKRSQECSVCLSEFQDEEKLRIIPNCSHLFHIDCIDVWLQNNANCPLCRTRVSCDTSFPPDRVSAPSTSPENLVMLRGENEYVVIELGSSIGSDRDSPRHGRLLTGQERSNSGYLLNENTQNSISPSPKKLDRGGLPRKFRKLHKMTSMGDECIDIRRGKDEQFGSIQPIRRSISMDSSADRQLYLAVQEAIRKNREVLVVGDGGGCSSSSGNVSNSKVKRSFFSFGSSRRSRSSSKLPLYFEP
What are the official names of this protein?
RING-H2 finger protein ATL16, RING-type E3 ubiquitin transferase ATL16.
What is the protein family that this protein belongs to?
Belongs to the RING-type zinc finger family. ATL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: WZYE_ECO57
Sequence: MSLLQFSGLFVVWLLCTLFIATLTWFEFRRVRFNFNVFFSLLFLLTFFFGFPLTSVLVFRFDVGVAPPEILLQALLSAGCFYAVYYVTYKTRLRKRVADVPRRPLFTMNRVETNLTWVILMGIALVSVGIFFMHNGFLLFRLNSYSQIFSSEVSGVALKRFFYFFIPAMLVVYFLRQDSKAWLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGMNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYDNIDFQGLAPIVRDFYVFIPSWLWPGRPSMVLNSANYFTWEVLNNHSGLAISPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNRETNRYKAAILHSFCFGAIFNMIVLAREGLDSFVSRVVFFIVVFGACLMIAKLLYWLFESAGLIHKRTKSSLRTQVEG
What is the function of this protein?
Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
What are the official names of this protein?
Probable ECA polymerase.
What is the protein family that this protein belongs to?
Belongs to the WzyE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL20_HELMI
Sequence: MARVKTGPMSRKRHKKILKLARGYRNAHSKLFRTAHQSVMKALSYAYAHRKKKKGDFRKIWITRINAAARMNGISYSVMMNGLKKAGVAVNRKMLADLAVNDLPAFAKLVDVAKAKGNA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: NIPA3_MOUSE
Sequence: MGVQLRLPPGEPCHEGYVLSLVCSNSSRASCEITNVSESLPYPVVYTNLNSSKTNFSISASVENKYNLYVGLVLAISSSVFIGSSFILKKKGLLQLADKGITRAGQGGHSYLKEWLWWAGLLSMGAGEAANFAAYAFAPATLVTPLGALSVLISAILSSYFLNERLNIHGKIGCILSVLGSTVMVIHAPQEGEVTSLHEMEMKLRDPGFVSFAVIISVISLVLILIVAPKKGQTNILVYIAICSLIGAFSVSSVKGLGIAIKELLERKPVYKDPLFFILLTMLALSVTTQINYLNKALDTFNTSLVTPIYYVFFTSMVVTCSAILFQEWYGMKAGDIIGTLSGFFTIINGIFLLHAFKNTNITWSELMSTAKKEALSPNGNQNSYVLLENADFSASGYDDDITLFSRTNDQSSHKL
What is the function of this protein?
Acts as a Mg(2+) transporter.  Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+).
What are the official names of this protein?
Magnesium transporter NIPA3, NIPA-like protein 1, Non-imprinted in Prader-Willi/Angelman syndrome region protein 3 homolog.
What is the protein family that this protein belongs to?
Belongs to the NIPA family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: VP6_ROTH6
Sequence: MDVLYSLSKTLKDARDKIVEGTLYSNVSDLIQQFNQMIITMNGTEFQTGGIGNLPIRNWNFGFGLLGTTLLNLDANYVETARNTIDYFVDFVDNVCMDEMVRESQRNGIAPQSDSLRKLSGIKFKRINFDNSSEYIENWNLQNRRQRTGFTFHKPNIFPYSASFTLNRSQPAHDNLMGTMWLNAGSEIQVAGFDYSCAINAPANTQQFEHIVQLRRVLTTATITLLPDAERFSFPRVINSADGATTWYFNPVILRPNNVEVEFLLNGQIINTYQARFGTIIARNFDTIRLSFQLMRPPNMTPAVAALFPNAQPFEHHATVGLTLRIESAVCESVLADASETMLANVTSVRQEYAIPVGPVFPPGMNWTDLITNYSPSREDNLQRVFTVASIRSMLVK
What is the function of this protein?
Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices.  This capsid constitutes the middle concentric layer of the viral mature particle.  The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus.  Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes.  VP6 is required for the transcription activity of the DLP.
What are the official names of this protein?
Intermediate capsid protein VP6.
What is the protein family that this protein belongs to?
Belongs to the rotavirus VP6 family.
What are the subcellular locations of this protein?
Virion. Note=Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Protein: ILVD_SHEB5
Sequence: MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVASAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAGADSNVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVMALAKRYYHQDDESALPRNIANFKAFENAMTLDIAMGGSSNTVLHLLAAAQEADVDFTMADIDRMSRLVPHLCKVAPSTPKYHMEDVHRAGGVMGILGELDRTGLLHTDVFHVAADNDGTPGSGTLKSVLAQYDVMQTQDEKVKHFFMAGPAGIPTTKAFSQDCRWPSLDNDRQEGCIRSREFAFSQEGGLAVLSGNVAENGCIVKTAGVDESNLTFVGSARVYESQDDAVAGILGGEVVAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPKRSIKLAVSDVELNARREKMHSLGPMAWKPIGRQRYVSLALKAYAMLATSADKGAVRDRSKLED
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: RL27_GEOSL
Sequence: MAHKKGVGSTRNGRDSESKRLGCKKFGGETVKAGNIIYRQRGTQIHPGTNVGCGKDYTLFALIDGVVKFERLGRDRKKVSVYPAN
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: AKAP5_BOVIN
Sequence: MEITVSEIQVESKDETRSAEVRPQDERQEEKASMLCFKRRKKAAKAMKPKASSKAADAAKKCPPEARASDQPQRPGGAWDSIKRLVTRRKRSESSKQQKPFKAKLQSEINAEDANPSKKKAKSRLKIPCIKFSKGEKRSNHSKIIEDSDRSVKVQEAENLVTKTQTQSDDQATKSKSPQDVREDVSQKGDDEVCESNVNNSITSPGEKVISVELELDMGHSAIQRGTLILEKDTEMLEEKQSIQPQHVSPLEASDTEQELPVGSEVPPSSAVPDQQILEEARNGVLESGPDWKEHESREIVVEESKPKDTELSQELDFQENEITAEKPKPEESKRMEPIAIIITDTEISEFDVKKSKNVPKPFLISIENEQVGVFANDSGFEGRTSEQYETLLIETASSLVKNAIQLSIEQLVNEMASDDNTINNRLQ
What is the function of this protein?
Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors.  Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.  Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses.
What are the official names of this protein?
A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 75 kDa, AKAP 75, P75, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein.
What are the subcellular locations of this protein?
Postsynaptic recycling endosome membrane; Lipid-anchor. Note=Associates with lipid rafts.
Protein: LEPA_DELAS
Sequence: MNHIRNFSIIAHIDHGKSTLADRLIQRCGGLADRDMEAQVLDSMDIEKERGITIKAQTAALQYKAKDGQVYNLNLIDTPGHVDFSYEVSRSLSACEGALLVVDASQGVEAQTVANCYTALELGVEVTAVLNKMDLPQADPENARAEIEDVIGIDASDAIPCSAKTGMGIEEILEAVVAKVPPPKGDPNGQLRAMIIDSWFDTYVGVVMLVRVVDGELKRGERFKMMASGAAYEANNLGVFTPADVPRDVLRAGEVGYIIAGIKELKAAKVGDTITLEKKLPNNLGPATEALPGFKEIKPQVFAGLYPTEASEYDQLRDALEKLQLNDSSLQFEPEVSQALGFGFRCGFLGLLHMEIVQERLEREFDQDLITTAPSVVYEVVKGDGEVIQVENPSKMPDAGRIEEVREPIVTVHLYMPQDYVGPVMTLANQKRGVQINMQYHGRQVMLTYEMPLGEIVLDFFDKLKSVSRGYASMDYEFKEYRASDVVKVDILLNGEKVDALSIIVHRSQATYRGRAVVAKMREIISRQMFDVAIQAAIGANIIARETVKAMRKNVLAKCYGGDITRKRKLLEKQKAGKKRMKQIGSVEVPQEAFLAILQVED
What is the function of this protein?
Required for accurate and efficient protein synthesis under certain stress conditions.  May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes.  Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly.  Binds to ribosomes in a GTP-dependent manner.
What are the official names of this protein?
Elongation factor 4, EF-4, Ribosomal back-translocase LepA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: Y1243_RENSM
Sequence: MTSGQSTSTPRRRRGALLPTLIILVLAIIAFVFFANVYTEVLWFNQLGFGGIFWQQNISKAIIFVAAFLVMSIAVYFSIRIAYRARPVYAPDSQVQDNLNHYQAQLEPVRKVVMIGVPIVFGVFAGAAALGQWQKVLLFLFQVPFGQTDPQFGMDISFYTNTLPFFGFLSGFLIAVVLISGIAALLTHYLYGAIRLQERGIFTSRAARVQLAVMAALFLIILGVNFFLDRFATLQNNGALRSGAMYTDVNAVIPTKAILAVAAGIVAILFIVAAVVGRWRLPVIGAAMLIITSIVAGGIYPWVIQQFQVGPSEASVEKPYIQRNIDMTRSAYGINDVEVIPYKASTTATPGALRQDATTTANIRLLDPNLMSQTFGQLEQYRPYYGFQKTLNVDRYTVDGKSQDTVIALRELNSGGIPAEQQTWYNKKLVYTHGYGVVAAYGNTATADGKPVFMQSGVPTNGKLGDDNSYQPRIYFGQSTTDYSIVGAGEGTASVELDRPQGGDNSSDSKNTFSGNGGPDVGNWFNRLAYSIKFQSTDLLLSDGVNSKSQILYDRTPVQRVQKVAPYLTIDGNPYPAIVDGKVKWIVDGYTTSNAYPYSQQQPLDSATSDSLTQRSGSGALAGSINYIRNSVKATVDAFDGSVNLYAWDDKDPILKTWQNIFPATIKPISEMSGALLSHIRYPEDLFKVQRELLGRYHVTNATEFYNNTNAWSVPNDPTTGDNTKQPPYYMSLQMPGQNAPAFSLTSNLIPQQVGANTRNVLYGYLAADADAGSTQGVKSDSYGKLRLLSLPTDTQVPGPGQVFNKFVSDPSVSSSLNLLKQGQSQVVNGNLLTLPVGDGLLYVQPVYVQSSTGGSSYPTLQKVLVAFGDKIAFAATLSAALDQLFGGDSGAVTGDKDKPTTPGTGGTGGNTGTPGENPDAKAALAKSLQDANQAIKDGQDALSKGDFTAYGTAQKKLNDAITAALAAEGKLDVTAPGSTGAPTGSAPPSTPPTAGSSTGSPTP
What are the official names of this protein?
UPF0182 protein RSal33209_1243.
What is the protein family that this protein belongs to?
Belongs to the UPF0182 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PSBT_STAER
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPKVPDRGSK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: RS5_BURP6
Sequence: MAKMQAKVQADERDDGLREKMISVNRVTKVVKGGRILGFAALTVVGDGDGRVGMGKGKAKEVPVAVQKAMEQARRNMFKVPLKNGTLQHEVHGKHGASTVLLAPAKDGTGVIAGGPMRAVFDVMGVQNVVAKSHGSTNPYNLVRATLDGLRKQSTPADIAAKRGKSVEEILG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.