PharMolix/UniProtQA huggingface dataset:
Protein: EFG_CYTH3
Sequence: MARDLKFTRNIGIAAHIDAGKTTTTERILYYAGVNHKIGEVHEGGATMDWMAQEQERGITITSAATTVGWKYRDNQYHVNIIDTPGHVDFTVEVNRSLRVLDGLVFLFSAVDGVEPQSETNWRLANNYKVARLGFVNKMDRSGADFLNVCKQVKEMLGSNAVPLQLPIGSEDNFQGVVDLVNNRAIVWNEADKGMTFTEVPIPADMVDETLEYREKLLEAVADYDETLMEKFFEDPNSISETEILTALRKAVLDMKIVPMLCGSSFKNKGVQTMLDYVMELLPSPLDKDDLVGINPDTDKEVVRKPVETDPFCALAFKIATDPFVGRLCFVRSYSGLLESGSYVYNTRSGNKERISRIFQMHANKQNQIDRLHCGDIGAVVGFKDIKTGDTLCDEKNKIILESMVFPEPVIGYAIEPKTQADVDKMGVAIAKLVEEDPTLHVHTDQETGQTILRGMGELHLEIIIDRMRREFKVEINQGAPQVAYKESLTKSTEHREVFKKQSGGRGKFADIVFELSPREDDKLGLEFENKIVGGVIPKEFIPSIQKGFEEAMKNGVIAGFPVESMKVRLNHGSFHDVDSDALSFELAARQGFKEAAKNAGAKIMEPIMSVEVVTPEEYTGPVTGDLNRRRGMMKGMDSKMGAQVIKADVPLSELFGYVTDLRTISSGRATASLTFSHYEFVPANLAETIVAKVKGTAVSK
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FIMA_DICNV
Sequence: MKSLQKGFTLIELMIVVAIIGILAAFAIPAYNDYIARTQVSEGVSLADGLKIRIADNLQDGKCTSEGDPASGEVGNTDMGKYALATIEGTPDANLAGLTPKDPNGCKVKIEYGKGTAGDNISPLIKGQMLVLNQLVNGSYDKDSSSTVKPKFLPKALKEATP
What is the function of this protein?
Major component of the type IV fimbriae that plays an essential role in twitching motility, natural transformation, and protease secretion.
What are the official names of this protein?
Type IV major fimbrial protein FimA.
What is the protein family that this protein belongs to?
Belongs to the N-Me-Phe pilin family.
What are the subcellular locations of this protein?
Fimbrium. Membrane; Single-pass membrane protein.
Protein: RL19_THIDA
Sequence: MNIIEQLEQEEIARLGKTVPDFAPGDTVVVQVKVKEGNRERLQAYEGVVIAKRNRGLNSAFTVRKISAGEGVERTFQTYSPLVASVEVKRRGDVRRAKLYYLRERSGKSARIKEKLPARKASVAAE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: CAPSD_CSMV
Sequence: MSPASSWKRKRPSSSSAQASKKRRVYRPAVSRSLARREPLQVQDFVWDTDVAFNRGGGCYLLTSYARGSAENQRKTAETITYKVAVNLGCAISGTMQQYCISSRPVCWIVYDAAPTGSAVTPKDIFGYPEGLVNWPTTWKVARAVSHRFIVKRRWVFTMESNGSRFDRDYTNLPAAIPQSLPVLNKFAKQLGVRTEWKNAEGGDFGDIKSGALYLVMAPANGAVFVARGNVRVYFKSVGNQ
What is the function of this protein?
Encapsidates the viral genome into characteristic twinned ('geminate') particles.  Binds the genomic viral ssDNA and shuttles it into and out of the cell nucleus.  Plays a role in protection of the genome from degradation, virus acquisition and transmission by insect vectors, infectivity, and systemic movement.  The CP of monopartite geminiviruses is absolutely essential for virus movement (By similarity).
What are the official names of this protein?
Capsid protein, Coat protein, CP.
What is the protein family that this protein belongs to?
Belongs to the geminiviridae capsid protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Note=It is actively transported into the host cell nucleus. It may be exported out of the nucleus through a nuclear export signal for cell- to-cell movement and spread (By similarity).
Protein: TRA6_BURM1
Sequence: MAMRVETNPLEAAYAALLENGLDGAGEALRILVNEAAKIERSAFLGARPYERTETRRDYANGFKPKTVLTRHGELTFQVPQVRSSDFYPSALEKGTRTDQAVNLALAEMYVQGVSTRRVIDVLQRLLGPEISLSSAQVSRAAAKLDEGLRAWRERPLGETPYLFLDARYEKVRLEGRIVDCAVLIAVGIEASGKRRVLGCEVATSEAEINWRRFLESLLARGLKGVTLIIADDHAGLKAARRAVLPSVPWQRCQFHLQQNAGALTTRQEARKTVAAQMRAIFNAPDRTEAERLLKAALTLWCKEHPKLAEWAETAIPESLTVFDFPAAHRIRLRTTNGLERINRELRRRTRVASIFPNPDSCLRLVSALLAELDDEWMTGKVYLNFNP
What is the function of this protein?
Required for the transposition of the insertion element.
What are the official names of this protein?
Transposase for insertion sequence element IS406.
What is the protein family that this protein belongs to?
Belongs to the transposase mutator family.
Protein: XYLA_ECOL6
Sequence: MQAYFDQLDRVRYEGSKSSNPLAFRHYNPDELVLGKRMEEHLRFAACYWHTFCWNGADMFGVGAFNRPWQQPGEALALAKRKADVAFEFFHKLHVPFYCFHDVDVSPEGASLKEYINNFAQMVDVLAGKQEESGVKLLWGTANCFTNPRYGAGAATNPDPEVFSWAATQVVTAMEATHKLGGENYVLWGGREGYETLLNTDLRQEREQLGRFMQMVVEHKHKIGFQGTLLIEPKPQEPTKHQYDYDAATVYGFLKQFGLEKEIKLNIEANHATLAGHSFHHEIATAIALGLFGSVDANRGDAQLGWDTDQFPNSVEENALVMYEILKAGGFTTGGLNFDAKVRRQSTDKYDLFYGHIGAMDTMALALKIAARMIEDGELDKRIAQRYSGWNSELGQQILKGQMSLADLAKYAQEHNLSPVHQSGRQEQLENLVNHYLFDK
What are the official names of this protein?
Xylose isomerase.
What is the protein family that this protein belongs to?
Belongs to the xylose isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLRX1_SALTI
Sequence: MFTVIFGRPGCPYCVRAKELAEKLSKERDDFNYRYIDIHAEGITKADLEKTVGKPVETVPQIFVDQKHIGGCTDFEAWAKENLNLFA
What is the function of this protein?
The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.  In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase (By similarity).
What are the official names of this protein?
Glutaredoxin 1, Grx1.
What is the protein family that this protein belongs to?
Belongs to the glutaredoxin family.
Protein: EFEB_SHIF8
Sequence: MQYKDENGVNEPSRRRLLKGIGALAGSCPVAHAQKTQSAPGTLSPDARNEKQPFYGEHQAGILTPQQAAMMLVAFDVLASDKADLERLFRLLTQRFAFLSQGGAAPETPNPRLPPLDSGILGGYIAPDNLTITLSVGHSLFDERFGLAPQMPKKLQKMTRFPNDSLDAALCHGDVLLQICANTQDTVNHALRDIIKHTPDLLSVRWKREGFISDHAARSKGKETPINLLGFKDGTANPDSQNDKLMQKVVWVTADQQEPAWTIGGSYQAVRLIQFRVEFWDRTPLKEQQTIFGRDKQTGAPLGMQHEHDVPDYASDPEGKVIALDSHIRLANPRTAESESSLMLRRGYSYSLGVTNSGQLDMGLLFVCYQHDLEKGFLTVQKRLNGEALEEYVKPIGGGYFFSLPGVKDANDYLGRALLQV
What is the function of this protein?
Involved in the recovery of exogenous heme iron.  Extracts iron from heme while preserving the protoporphyrin ring intact.
What are the official names of this protein?
Deferrochelatase, Peroxidase EfeB.
What is the protein family that this protein belongs to?
Belongs to the DyP-type peroxidase family. EfeB subfamily.
What are the subcellular locations of this protein?
Periplasm.
Protein: RLMH_THET2
Sequence: MRLRVVAVGRPRLAYARLGVEEYARRMRRYAPLDLVFVRKGEELLPKAEGHRKVVLDERGRLLTTEELYRRLLVWEGERVAFLVGGAEGHPEAVREEADLLLSLSPLTLQHELALLVLMEQLYRVLTLRAGHPYHRP
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BIOD_NITHX
Sequence: MSTRIVVTGTDTGIGKTVFSAALAGALDGFYWKPIQAGLDDETDTQTVLRLSGLAAERVLPEAYRLRTPASPHLAAELDGVTIEHQALLVPEKDRPLVVEGAGGLLVPLTRTITYLDLMARWRIPVVLCARTALGTINHSLLSVEALRARGVAMLGIAFIGEENVESERIITEMGKVRRLGRLPHVAPLTRDTLREAFADGFAIDDFLKGPA
What is the function of this protein?
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
What are the official names of this protein?
ATP-dependent dethiobiotin synthetase BioD, DTB synthetase, DTBS, Dethiobiotin synthase.
What is the protein family that this protein belongs to?
Belongs to the dethiobiotin synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DSBB1_PSEAE
Sequence: MPLASPRQLFLLAFLACVAIMGGALYLEHVVGLEACPLCVVQRIFFILIGLTCLAGAIQGPGLRGRRIYSVLVFLLALGGGATAARQVWLQTVPLDQLPACLPSLDYMMQALPFQEVIRLVLHGTADCAQVSWTLFTLSIPEWSLLAFVAYLGFSIVQFLRRA
What is the function of this protein?
Required for disulfide bond formation in some periplasmic proteins.  Acts by oxidizing the DsbA protein (By similarity).
What are the official names of this protein?
Disulfide bond formation protein B 1, Disulfide oxidoreductase 1.
What is the protein family that this protein belongs to?
Belongs to the DsbB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RR15_CRYJA
Sequence: MIKNLSVRPSLIPREQRGSVESQVCYLTGRIKRLTEHLDLHGRDYSSQRGLWKIVGKRKRLLIYLFKKDRLRYKSLIGQLDMRGPR
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: MAP21_ASPFN
Sequence: MAAQASEDLQKLDLNGQGGAAKADAPTAGQAEAGEAEDDSDDDADEGNAAPEGGANGAAKKKKKRKSKKKKKGGAKVQSEPPRVPLSQLFAGKQYPEGEIVEYKDDNLYRTTNEEKRYLDRMNNDFLQEYRQGAEVHRQVRQYAQKTIKPGQTLTEIAEGIEESVRALTGHQGLEEGDNLKGGMGFPCGLSINHCAAHYTPNAGNKMVLQQGDVMKVDFGAHINGRIVDSAFTVAFDPVYDPLLEAVKDATNTGIREAGIDVRMSDIGAAIQEAMESYEVELNGTMHPVKCIRNLNGHNIDQHVIHGGKSVPIVKGGDQTKMEEGEVFAIETFGSTGKGYVREDMETSHYALVPNASPVPLRLSSAKNLLNVINKNFGTLPFCRRYLDRLGQDKYLLGLNNLVSSGIVQDYPPLCDIKGSYTAQYEHTIVLRPNVKEVISRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-1, MAP 2-1, MetAP 2-1, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTPX_NEIMA
Sequence: MKRIFLFLATNIAVLVVINIVLAVLGINSQGGTGSLLAYSAVVGFTGSIISLLMSKFIAKQSVGAEVIDTPRTEEEAWLLNTVEAQARQWNLKTPEVAIYHSPEPNAFATGASRNSSLIAVSTGLLDHMTRDEVEAVLAHEMAHVGNGDMVTLTLIQGVVNTFVVFLSRIIANLIARNNDGSQSQGTYFLVSMVFQILFGFLASLIVMWFSRQREYRADAGAAKLVGAPKMISALQRLKGNPVDLPEEMNAMGIAGDTRDSLLSTHPSLDNRIARLKSL
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VE8E2_HPV31
Sequence: MAILKWKRSRWYSSDEISFAGIVTKLPTANNTTTSNSKTCALGTSEGVRRATTSTKRPRTEPEHRNTHHPNKLLRGDSVDSVNCGVISAAACTNQTRAVSCPATTPIIHLKGDANILKCLRYRLSKYKQLYEQVSSTWHWTCTDGKHKNAIVTLTYISTSQRDDFLNTVKIPNTVSVSTGYMTI
What is the function of this protein?
Plays a role in limiting the replication of viral DNA in keratinocytes.  Recruits the host NCoR/SMRT complex to viral replication foci to mediate repression of both viral replication and transcription.
What are the official names of this protein?
Protein E8^E2C.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E8^E2C protein family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: GATD_METST
Sequence: MAYEEYLKDFLEISNITVGDTVKVTKPHIEHEGMLLEKPDYSNENTIILKLDSGYNIGIDIKDAKIEKISEGKKPQIELDPVDKKISDKKKNLSILSTGGTVASVIDYKTGAVHPAFTADDLLRATPELVDYANINAKAIFNILSENMTPEYWKKTATTIYDEINNGADGIIIAHGTDTMHYTASALSFMIDSPVPIVLTGAQRSSDRPSSDAFTNLMASVNAAKSDIAEVTICMHGTEDDSYCDLHRGTRARKMHTSRRDTFTSINMNPLARIENNKVTINDTQVKYTKRNEKELSLNTNLADKVALIKMYPGISPEIIDIYVDKNYDGIVIEGTGLGHCSDDVITSITRATSEDIPVVMTSQCLFGRTNMNVYSSGRRLLQNNVIGVGDMLPETAYTKLLWAAGQTDNVSEIYEIMKTNLKGEMDTTLSQNYFIKN
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).  The GatDE system is specific for glutamate and does not act on aspartate.
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit D, Glu-ADT subunit D.
What is the protein family that this protein belongs to?
Belongs to the asparaginase 1 family. GatD subfamily.
Protein: NPIIC_ARTOC
Sequence: MQLIAFLAALGVPVAFAATIPSVPLNHSMIDVKLSAAGNSMVKATITNNGDRALNLLRFNTIMDEHPTRKVMVYQNGAEVQFTGMLPRYMMSNLTPDYFVSLGPKASVEHSFDLAATHDLSRGGKITVMAQGTVPTAEEHGTTITGHTVYESNKITMEVDGNKAAAVVQAMGKVKAGSIDKRSKVVTSSCHGNQLQVLQTALANSARLSQAAAKAAQSNPRKLQEYFKATDSGTVQKVVSRFMSVARESSSNSAGGTTYYCNDSMGGCHPGVLAYTLPSQNLVVNCPIYYSDIPALNKRCHGQDQATTTLHEFTHNPAVVSPFAQDLGYGYDRVAALPASKAIQNADTYALFANAIYVGC
What is the function of this protein?
Probable secreted metalloprotease that shows high activities on basic nuclear substrates such as histone and protamine (By similarity).  May be involved in virulence.
What are the official names of this protein?
Probable neutral protease 2 homolog MCYG_04257, Deuterolysin MCYG_04257.
What is the protein family that this protein belongs to?
Belongs to the peptidase M35 family.
What are the subcellular locations of this protein?
Secreted.
Protein: PAF1_ARATH
Sequence: MASYRPPYPPLPQPPSQNSLAPPPPPPSLPPPVPPPPPSHQPYSYPPPPPPPPHAYYQQGPHYPQFNQLQAPPPPPPPSAPPPLVPDPPRHQGPNDHEKGASKQVGRRERAKPDPSKHHHRSHLPHSKKIETEEERRLRKKRELEKQRQDEKHRQQMKNSHKSQMPKGHTEEKKPTPLLTTDRVENRLKKPTTFICKLKFRNELPDPSAQLKLMTIKRDKDQFTKYTITSLEKLWKPKIFVEPDLGIPLDLLDLSVYNPPKVKAPLAPEDEELLRDDDAVTPIKKDGIRRKERPTDKGMSWLVKTQYISSINNESARQSLTEKQAKELREMKGGINILHNLNNRERQIKDIEASFEACKSRPVHATNKNLQPVEVLPLLPYFDRYDEQFVVANFDGAPIADSEFFGKLDPSIRDAHESRAILKSYVVAGSDTANPEKFLAYMVPSLDELSKDIHDENEEISYTWVREYLWDVQPNANDPGTYLVSFDNGTASYLPLPMRLNLRKKRAREGRSSDEIEHFPVPSRVTVRRRSTVSVIEHKDSGVYSSRVGASSSKMRRLEDEGGLGRSWKHEPEQDANQYSDGNEDDYSE
What is the function of this protein?
Component of the PAF1 complex (PAF1C) which is involved in histone modifications such as methylation on histone H3 'Lys-4' (H3K4me3) (PubMed:20363855).  Involved in regulation of flowering time.  Required for the expression of the flowering repressors and MAD-box genes FLC, AGL27/FLM and AGL31/MAF2.  Required for histone H3 trimethylation on 'Lys-4' H3K4me3 at the FLC and AGL27/FLM loci (PubMed:15520273).  Involved in the control of seed dormancy and germination (PubMed:21799800).
What are the official names of this protein?
Protein PAF1 homolog, Protein EARLY FLOWERING 7, Protein VERNALIZATION INDEPENDENCE 2.
What is the protein family that this protein belongs to?
Belongs to the PAF1 family.
Protein: DNAJ_SHEON
Sequence: MSKRDYYEVLGVGRDASEREIKKAYKRLAMKFHPDRNPGDKAAEASFKEVKEAYEILTDANKKAAYDQFGHAGVDPNRGGGGGYGGAGDFGDIFGDVFGDIFGGGRRGGGQRQAARGSDLRYNLELSLEEAVKGLTKELRIPTLASCDVCDGSGAKKGTSATTCTTCHGQGQVQMRQGFFTVQQPCPTCHGRGKIIKDPCAKCHGDGRVEKTKTLSVKIPAGVDTGDRIRLAGEGEAGEFGAPAGDLYVQVSVREHAIFVRDGNNLYCEVPISFSKAALGGEIEVPTLDGKVSLKIPAETQTGRMFRLRGKGVKSVRSHAVGDLLCKVVMETPVNLNERQKELLREFEATLTGESKKHSPKAEGFFDGVKKFFQDLNS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GATB_SCHJY
Sequence: MSSLARWIITIGLEVHVQLSTKLKLFSRALAENHKAPNSAVSFFDISLPGTLPIVNPEAIRLATKAALVCNCEIAPSLEFDRKHYVYSDQRAGFQITQKRRPLGTNGFVRLNAALDGVEKDQLVEIKCLQLEQDTGKTVNELNEDLVLLDFNRANVPLIEVVTAPCFHSPHDAACFLRKLQTILRLANVSDAKMELGNMRCDVNVSVASAENPTKQLATVELKNLPSIRYVEIASELEAKRQIELLNNGSSPVPETRSYDVEKNATVFLRKKRGPSDYMYLPEADIPEITLTSAYVDDVRKSIGPSVDELLETLLQKKYFNLQDAKALLQTEDGLSYYQVLVGELEKVTSSMSPDVQLKAEKLIPFWLVNEYVGDCANAPDEKRDLDTIPPADLAFLLGNLANGTLSAYAAKHILQLAVQDPKKNSIYKLVNENANAEFDENTLKDLVNELIQANGDKVNALKVGKDGVLNWFIGNVMRRSSGKAKPDEIKRLINNTVLCENSSK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial, Glu-AdT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: ILVC_SOLM1
Sequence: MKIYYDQDADLSLLADKTVAIIGYGSQGHAHAQNLRDSGVKVVIGQRPGGPNWELAKENGFTPMSAAEAAAAADLIMILVPDQHQKAVYEKDVLPHLKPGKMLLFAHGFNIHFQQIVPPADVDVAMVAPKGPGHLVRRVYTEGAGVPCLIAIHQNATGKAMETALAYAKGVGGTRGGVLTTTFKEETETDLFGEQAVLCGGAAELVKAGFETLCEAGYQPEIAYFECLHELKLIVDLMYEGGLSRMRYSISDTAEYGDYVSGPRVVTDETRAEMRQILKEIQDGTFARDFIMENMSGRAHFLSMRRINAEHPIEKVGAKLRGMMSWLKK
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: CS012_MOUSE
Sequence: MPIMVDDIMRLLCSISQERKMKAAVKHSGKGAMVAGAMAFVGGLVGGPPGIAVGGTVGGLLGAWMTSGQFKPVPQILMELPPAEQRKLVNEAMAIIGNLDWTDAVQLTALVMSNQAMQQRLLAMLTTYVTKELQAEIRYED
What are the official names of this protein?
Protein C19orf12 homolog.
What is the protein family that this protein belongs to?
Belongs to the C19orf12 family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In response to oxidative stress, relocates to the cytosol forming aggregates that partially co-localize with mitochondria.
Protein: TAM41_HUMAN
Sequence: MALQTLQSSWVTFRKILSHFPEELSLAFVYGSGVYRQAGPSSDQKNAMLDFVFTVDDPVAWHSKNLKKNWSHYSFLKVLGPKIITSIQNNYGAGVYYNSLIMCNGRLIKYGVISTNVLIEDLLNWNNLYIAGRLQKPVKIISVNEDVTLRSALDRNLKSAVTAAFLMLPESFSEEDLFIEIAGLSYSGDFRMVVGEDKTKVLNIVKPNIAHFRELYGSILQENPQVVYKSQQGWLEIDKSPEGQFTQLMTLPKTLQQQINHIMDPPGKNRDVEETLFQVAHDPDCGDVVRLGLSAIVRPSSIRQSTKGIFTAGKSFGNPCVTYLLTEWLPHSWLQCKALYLLGACEMLSFDGHKLGYCSKVQTGITAAEPGGRTMSDHWQCCWKLYCPSEFSETLPVCRVFPSYCFIYQSYRCIGLQKQQHLCSPSSSPSLRQLLPSVLVGYFCCYCHFSKW
What is the function of this protein?
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
What are the official names of this protein?
Phosphatidate cytidylyltransferase, mitochondrial, CDP-diacylglycerol synthase, CDP-DAG synthase, Mitochondrial translocator assembly and maintenance protein 41 homolog, TAM41.
What is the protein family that this protein belongs to?
Belongs to the TAM41 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein: ISCS_PSEA8
Sequence: MKLPIYLDYSATTPVDPRVAQKMSECLLMDGNFGNPASRSHVFGWKAEEAVENARRQVAELVNADPREIVWTSGATESDNLAIKGVAHFYSGKGKHIITSKIEHKAVLDTCRQLEREGFEVTYLEPGEDGLITSALVEAALRDDTILVSVMHVNNEIGTVNDIAAIGELTRSRGVLFHVDAAQSTGKVEIDLDKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEGQMHGGGHERGMRSGTLATHQIVGMGEAFRIAKEEMAQENARVLALRDRFFAQIDGLEELYINGSMTSRVPHNLNVSFNYVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTFGRFTTEEEIDYAAKKVVEAVSKLRELSPLWDMYKEGVDLSQVEWQAH
What is the function of this protein?
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis.  Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.  Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
What are the official names of this protein?
Cysteine desulfurase IscS.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSUG_CHLSY
Sequence: MLRIAEEVTTALEEGRAVVALESTLISHGLPYPHNLAVAEGLEAEVRAAGAVPATIGLIEGVPVIGLNGNELERLAVGGDRVRKLSRRDIGAAIVDHADGATTVAATMALAAAAGIEVFATGGIGGVHRGATHSWDVSADLTELGRTPVLVVCAGAKAILDLPATLEYLETQGVPVVGYQTVEFPAFYTPHSGLTVAAVAADALAAARMWRIQRRYHTFAAPGGMLLCVPPPERHALEREAVEAAIGRALARAEAEGVRGPAVTPFLLAAMAEETSGESIETNIALLRNNTRVAAEVAVRISELG
What is the function of this protein?
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil.  Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
What are the official names of this protein?
Pseudouridine-5'-phosphate glycosidase, PsiMP glycosidase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine-5'-phosphate glycosidase family.
Protein: MCE_SHEVK
Sequence: MEAVSMDKPFMYFDEIDNELEYDPKTSEEKPKKLPYQGQLKLLLCELFFLSKLQRHGILDGCTIVYVGSAPGTHIKYLRDHFLSMGLVIRWILIDGRQHDTILNGLRDVTLITKFVDESYIRVLKKQLYQSKIVLISDVRSKRGGNEPSTFDLLSNYALQNIMVSILKPAASSLKWRCPFPDQWVKDFYIPHGNEMLQPFAPKYSAEIVNNIYSGNPIKL
What is the function of this protein?
Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities.  Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation.  At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap.  At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail.  In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.
What are the official names of this protein?
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, Poly(A) polymerase regulatory subunit, Poly(A) polymerase small subunit, PAP-S, VP39.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Poxvirus/kinetoplastid 2'-O-MTase family.
What are the subcellular locations of this protein?
Virion. Note=Localizes to the virion core.
Protein: RL7_SHESR
Sequence: MSITKDQILEAFAAMSVMEVVELIEAMEEKFGVSAAAAVVAGGAADAGAAAEEQTEFTVMLTAHGDNKVAVIKAIRGATGLGLKEAKAMSEAAPVAVKEGVSKEEAEALKKELVEAGATVEIK
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.  Is thus essential for accurate translation.
What are the official names of this protein?
50S ribosomal protein L7/L12.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL12 family.