PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_LEVBA
Sequence: MAKKKSKKTPDNVLAQNRKARHDYTVLETVEAGIALTGTEIKSVRERRVNLQDGFAQIRNNEAWLMNVHISEYVQGNRFNHDPLRNRKLLLHKKEIRRLGQATMDKGVTLVPLRMYLKHGFAKVLIGVAQGKREFDKRETIKRREQDRQIARVMKHY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PMEA_EMENI
Sequence: MRVQSYLSLFSLVGAALCAPREHFKRTARTSAPAGCLTVGGSGTYSTIGAAFAALGSSSSEACIYISAGTYKEQLTFQYAGPLTLYGETTDTSSYKKNTVTITHTISSPEAGSLVASATVNAAMDNFTMYNINVVNGYGKGAQAVALAASGERQGYYGCQFLGYQDTLYARVGVQYYSNCYIEGAVDYIFGDASAWFGECDIVSNGAGYITAMSRETASDPAWYCFDHCNIYGKSGLDLTGDVYLGRPWRVLARVIYQNSELSDIINAAGWTTMAEGATPLYYEIGNTGDGADTSKRLYLSEISAAVTKATVLGSDWTDWLDWSY
What is the function of this protein?
Involved in maceration and soft-rotting of plant tissue.  Active against citrus pectin.
What are the official names of this protein?
Pectinesterase A, Pectin methylesterase A.
What is the protein family that this protein belongs to?
Belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted.
Protein: 3MGH_STAA9
Sequence: MDFVNNDTRQIAKNLLGVKVIYQDTTQTYTGYIVETEAYLGLNDRAAHGYGGKITPKVTSLYKRGGTIYAHVMHTHLLINFVTKSEGIPEGVLIRAIEPEEGLSAMFRNRGKKGYEVTNGPGKWTKAFNIPRAIDGATLNDCRLSIDTKNRKYPKDIIASPRIGIPNKGDWTHKSLRYTVKGNPFVSRMRKSDCMFPEDTWK
What are the official names of this protein?
Putative 3-methyladenine DNA glycosylase.
What is the protein family that this protein belongs to?
Belongs to the DNA glycosylase MPG family.
Protein: RLMH_STAA1
Sequence: MKITILAVGKLKEKYWKQAIAEYEKRLGPYTKIDIIEVPDEKAPENMSDKEIEQVKEKEGQRILAKIKPQSTVITLEIQGKMLSSEGLAQELNQRMTQGQSDFVFVIGGSNGLHKDVLQRSNYALSFSKMTFPHQMMRVVLIEQVYRAFKIMRGEAYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH1_SPHTD
Sequence: MAENKWLRNGFVWIVLIIAVVALWVTFMKDGGSAREENFADVAADIRQGRVARIVMTEGSNDIQVQYIGEEEPRSSRLPPDVNIYQALEQYGLSGADVEIRVNPASQWGNWLSALTFILPTLFLIGIVIFMMRQAQGTNNQAISFGKSRARMFTGNKPTVTFADVAGVEEAKEELVEVVEFLKYPDKFASLGARIPRGVLLVGPPGTGKTLLSRAVAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFDQAKRNAPCIVFIDEIDAVGRQRGAGLGGSHDEREQTLNQILVEMDGFDSTTNVIVIAATNRPDVLDPALLRPGRFDRQVVLDRPDIAGRRAILEVHSRGKPLESDVDLEELARQTPGFSGADLENLVNEAAILAARRNKKTIGRRELTEAIDRVIAGPERKSRVLSEREKLMTAYHEAGHALVARMLPHADPVHKVSIVARGMMGGYTRVLPEEDRFFWTKKQFEDQLAVFMGGHVAEELVFQEISTGAANDIERATNLARRMVTEYGMSKTLGPLAFGRKEELVFLGREINEQRNYSDEVAYMIDQEIRSLIDTAYKRAHEILSQHMDKLEAIAMLLMEAETIDGHELEALFDEPRPRPQLVGPPVTRPAALAHKTEEADRGGERSPHPQPHPSPTMRPQPAS
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH 1.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: CSRA_SHEB9
Sequence: MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQSEKSGTPSEGGNF
What is the function of this protein?
A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability.  Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems.  Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA.  Its function is antagonized by small RNA(s).
What are the official names of this protein?
Translational regulator CsrA, Carbon storage regulator.
What is the protein family that this protein belongs to?
Belongs to the CsrA/RsmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_YERPN
Sequence: MATNAKPVYQRILLKLSGEALQGAEGFGIDASVLDRMAQEVKELVELGIQVGVVIGGGNLFRGAGLAQAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDNYSWAEAISLLRHNRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPVKNPDATLYEQLTYQDVLEQELKVMDLAAFTLARDHNLPIRVFNMNKPGALRRVVMGENEGTLIAK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL27_HELMI
Sequence: MLVMNLQYFAHKKGVGSSRNGRDSEAKRLGVKRSDGQAVLSGNILVRQRGTKIHPGNNVGLGSDDTLFALIDGVVKFERKGRDKKQVSVYAV
What are the official names of this protein?
50S ribosomal protein L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: GCSH_RIPO1
Sequence: MDLEYPDDLRYLDSHEYVRLDGEIATIGLSAFAIEQLGDIVHLELPEVGEALEKGESFGAIESVKAAEDLYPPVSGTVIDRNEEMIENPDQLADDPYGDGWLIKVRVSNLDAELDDTLSASEYQAQLEGDDD
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: RS20_CHLFF
Sequence: MAPKKTTKKGGPKKRPSAEKRILTAQKRNLINQSFKSKAKTMMKKFEAALKAGDQTSISSGLQLVYSVADKAVKRGVFKSNKAARIKARATLRANAKV
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: YABA_STRPI
Sequence: MDKKELFDALDDFSQQLLVTLADVEAIKKNLKSLVEENTALRLENSKLRERLGEVEADAPVKAKHVRESVRRIYRDGFHVCNDFYGQRREQDEECMFCDELLYRE
What is the function of this protein?
Involved in initiation control of chromosome replication.
What are the official names of this protein?
Initiation-control protein YabA.
What is the protein family that this protein belongs to?
Belongs to the YabA family.
Protein: DAPF_BRUA4
Sequence: MATKAAFAKMNGLGNQIIVADMRGRADRITPEAAIRLAGDSETAFDQIMAIHDPRTAGTDNYIAIINCDGTEAQACGNGTRCVVQALAAETGRQAFTFETRAGILTATEHEDGLISVDMGKPRFDWQDIPLAEEFRDTRMIELQVGPIDAPVLHSPSVASMGNPHAIFWVDRDVWSYELEKFGPLLEHHPIFPERANISIAHVTSPETIDLRTWERGAGLTRACGSAACAAAVSAVRTRRTGRTVTVNVPGGPLRIEWRDDDHVMMTGPAEWEFSGTFDPATGEWSRDAQNDKPTDRGAA
What is the function of this protein?
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
What are the official names of this protein?
Diaminopimelate epimerase, DAP epimerase, PLP-independent amino acid racemase.
What is the protein family that this protein belongs to?
Belongs to the diaminopimelate epimerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y5481_STRCO
Sequence: MYEQLFSPTVQHTLDLVGIFVFAISGALLAVRKNFDVFGIAVLAEVTALGGGLFRDLVIGAVPPAAFTDLGYFLTPLLATLLVFFLHPHVERLQTGVNIFDAAGLGLFCVAGTTKAYDYGLGLTASACLGLTTAVGGGVLRDVLANEVPSLLRWDRDLYAVPAIVGSAMVALCIRYEALTPFTSGLAVVTAFVLRLLALRFHWRAPRAWNRRSTVVEGD
What are the official names of this protein?
UPF0126 membrane protein SCO5481.
What is the protein family that this protein belongs to?
Belongs to the UPF0126 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: APT_CLOPS
Sequence: MSLKDKIRVIEDFPKKGISFKDITTLIADGEGLRDSVDQMAEFFKDKNIDVVVGPEARGFIFGVPVAYALGVGFIPVRKPGKLPGDTVRVEYDLEYGKDALEIHKDAIKPGMRVAIVDDLLATGGTIAAVAKLVEQAGGEVAGLAFTIELTELKGRDKLKGYEVTSLVDYDV
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKA_CAMJE
Sequence: MKKFDKLGLDNIKEIFHNLSYDELNAHEKANNEGLSTDNDTFCVDTGIFTGRSPKDKYFVKQDPSSKYIAWGKVNQPITKELFDKLLTKAKQELSGKKIYVQDVFCGASLQSRKAVRFVTEIAWQAHFVKNMFIRPSQEELENFKADFIVYNACKCINEDYKQDGLNSEVFVIFNVEENIAVIGGTWYGGEMKKGIFSMMNYWLPLENKLSMHCSANVGEKDDVALFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDEGVFNFEGGCYAKTINLDPEHEPEIYGAIKRNALLENVVLRADKSVDYADASKTENTRVSYPIEHIENHEPSLKAGHPKNIIFLSADAFGILPPVSKLSKEQAMYYFLSGYTAKVAGTERGITEPQATFSACFGEPFMPLHPTVYARLLGEKIEKHEVNVYLVNTGWSGGSYGVGKRMSIKATRACINAILDGSITKCEFENFEVFDLAIPKALEGVESVLLNPINTWLDKNAYIATRDKLAHMFIQNFKRYEDVKEGIEFSKFGPKI
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_CHLPD
Sequence: MSKKQQPQTFVQAIHNRKARFEFHILETMVAGIELLGSEVKSVRQGKASLNESYAMIHHGEVWLENMQITPYEHNHLDTLEAKRSRKLLLNREEIRKLETKINEKGLTLVPLKAFFNNRGILKIEIALAKGKKLYDKRETIKSRDAERQLQQLKKTY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: PGK_PSEA6
Sequence: MSIINMTDLDLAGKRVLIRQDLNVPVKGGKVTSDARIKASLGTLKHALEAGAKVMVMSHLGRPTEGEYDSAFSLQPVVDYLNDVLECSVSLASDYLNGVDVKAGELVVLENVRFNVGEKKDDEALSKQYAALCDVYVMDAFGTAHRAQASTHGAGKFAPVACAGPLLAGELEALGKALHNPARPMLAIVGGSKVSTKLTVLESLSNKVDQLIVGGGIANTFIAATGNNVGKSLYEADLIPEANRLLAAAKDAGGNIPVPVDVVTGKEFSEQAQATLKAVSDVADDDMIFDIGPQTATELAELIKNAGTIVWNGPVGVFEFDQFGEGTKAIAMAIAQSNAFSIAGGGDTLAAVDKYGIEDKISYISTGGGAFLEFLEGKALPAVTMLEARGA
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFTU_FRASN
Sequence: MAKQKFERTKPHVNIGTIGHIDHGKTTLTAAITKVLHDAHPDLNPFTPFDQIDKAPEEKARGITISIAHVEYQTDARHYAHVDCPGHADYIKNMITGAAQMDGAILVVSATDGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEILELVELEVRELLNTYEFPGDDVPVIRVSALKALEGDKEWGEKLLELMAAVDASIPEPERDIDRPFLMPIEDVFTITGRGTVVTGRIERGIVKVNETVEIVGIKPETTTTTVTGVEMFRKLLDEGQAGDNVGLLLRGIKREDVERGQVIVKPKSITPHTVFEARVYILNKDEGGRHTPFFKNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTEMTVELIQPIAMEEGLRFAIREGGRTVGAGQVLKVIK
What is the function of this protein?
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
What are the official names of this protein?
Elongation factor Tu, EF-Tu.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y8453_DICDI
Sequence: MKRIISSSKSLKQLSNIGYGSKKQIHCKSVVDSDSDSDSDSDSDSDSDSNSNSNSNSNSNSNSNSNSNSNSNSNNNNNNTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSVFSELILKLIAERVILINNYNIEKIEEIKGIPELMKSITSTTAETKNNYYSGSYYSSR
What are the official names of this protein?
Putative uncharacterized protein DDB_G0283223.
Protein: GCSH_XANCB
Sequence: MSEIPGDLKFLKSHEWARVEGNGRVTVGISDHAQGLLGDLVYVELPAVGDTVQAGNGAAVVESVKAASDVYSPVTGTVVEVNASLSDKPETINEDAYGEGWIFVVEIDDKEQLNELLAPDDYAELLEDDAH
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
What are the official names of this protein?
Glycine cleavage system H protein.
What is the protein family that this protein belongs to?
Belongs to the GcvH family.
Protein: 3L21_AUSSU
Sequence: MKTLLLTLVVVTIVCLDVGNSFSCYKTPDVKSEPCAPGENLCYTKTWCDRFCSIRGKVIELGCAATCPPAEPRKDITCCSTDNCNPHPAH
What is the function of this protein?
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
What are the official names of this protein?
Long neurotoxin 1, LNTX-1.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CJ143_HUMAN
Sequence: MDSLALGRWRQRRAEDLQVPGDVKRVCRRLEASGHERGCHQVNACALASWGPEDRELPSRGCLPAPRPESGQGRLSTGISQNGGRSSAQPCPRCIAGESGHFSHTKNH
What are the official names of this protein?
Uncharacterized protein C10orf143.
Protein: ORYK_ASPOR
Sequence: MDIYEAASQGRIDAIKFAVEQGCDVDGPNEDGKTPLWFAVQSGQPEACRFLMSLGAGRGPQNPSLLEVAVGGGYADIVALLWPHCNAEREHRSLKTAISLGFHEIADFLIETGAFEYQDSEVSGTESLIEDGSPERESTVFQQWERFLFVRRGQKLPLHRVFFDYALLLATKAGRNAGLRLVEFLLGESMPDVNCKIMINGQFETPLTAAAEKGNLEILATLIDHPNIDLTICGKYNWPAFLHLLASPLSISTERGRVIARRLAYKAVYNRLFIDSREIRLQGAFQNVLRFGDDGLVKQVIDLVRGAAGTLILPLLIRANEVDGLTWVLNCDGVSSKKPPPAFWVLLCQYFKRYQDQDALGLFTSVTEFLVEKKIWNQAILKCLHACNFSFIQQFFYPLSEAPPKEVTEETLSPGFENLLFSNADLNGSDPHPNGLGRLELEIIPHAFFDDPSSAAQKISLRSALPSASPNPSNPHLYSYQMELIRLEQQNKRRLFFAGDTRCPLSWAAKSHNAPLVNALLRSPQVNVNFQDPSDRTPLLYAIAVNDRPIVERLLNHRDIDLNLRDAEGRTAIFYAAQGGDLSIVQLLIGTQNVDFSIRNKNGKNVKEFAKKAKLKQDIVAALSN
What is the function of this protein?
Ankyrin repeat domain-containing protein; part of the gene cluster that mediates the biosynthesis of oryzines, natural products with an unusual maleidride backbone (PubMed:30104550).  The two subunits of the fungal fatty acid synthase oryfasA and oryfasB probably form octenoic acid (Probable).  This fatty acid is most likely activated by the acyl-CoA ligase oryP to give octenyl-CoA before the citrate synthase-like protein oryE catalyzes condensation with oxaloacetate to form tricarboxylic acid (Probable).  The next steps of the pathways are conjectural, but a favorite possible route has been proposed, beginning with decarboxylation and concomitant dehydration by the decarboxylase oryM, followed by tautomerization, which may lead to the production of a diene intermediate (Probable).  Reduction of this diene intermediate could give the known metabolite piliformic acid (Probable).  On the pathway to oryzine B and oryzine A, however, hydroxylation of the diene by the alpha-ketoglutarate-dependent dioxygenase oryG and lactonisation by the lactonohydrolases oryH or oryL could give oryzine B directly (Probable).  Finally, enoyl reduction by the dehydrogenase oryD would then convert oryzine B into oryzine A (Probable).
What are the official names of this protein?
Ankyrin repeat domain-containing protein oryK, Oryzines biosynthesis cluster protein K.
Protein: HBBC_GYMUN
Sequence: VEWSSSERSTITSLWGKVIPAEIGPVAFARVLIVYPWTQRYFGNFGDLSNIAAISGNAKVAAHGKVVLDGVDKAVKNLDNIKGAYTSLSLLHSEKLNVDPDNFKLLGDCLTIVLATKFGAEFTPKVQAVWQKFLIVLIHALSRQYF
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin cathodic subunit beta, Hemoglobin cathodic beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: PLAS_THAOC
Sequence: AQTVEVKMGADGGLLVFEPAKAGPHNVVFDEDNIPPGV
What is the function of this protein?
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.
What are the official names of this protein?
Plastocyanin.
What is the protein family that this protein belongs to?
Belongs to the plastocyanin family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Lumenal side. Note=Loosely bound to the inner thylakoid membrane surface in chloroplasts (By similarity).
Protein: CCDB4_ECOLX
Sequence: MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEVADLSHRENDIKNAINLMFWGI
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system, functioning in plasmid maintainence.  Responsible for the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system.  Half-life of over 2 hours.  Interferes with the activity of DNA gyrase, inducing it to form a covalent GyrA-DNA complex that cannot be resolved, thus promoting breakage of plasmid and chromosomal DNA.  Toxicity is inhibited by labile antitoxin CcdA, which blocks the activity of CcdB; CcdA also removes bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation.  Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdA (By similarity).
What are the official names of this protein?
Toxin CcdB, Cytotoxic protein CcdB, Protein LetD.
What is the protein family that this protein belongs to?
Belongs to the CcdB toxin family.
Protein: NCBP1_YEAST
Sequence: MFNRKRRGDFDEDENYRDFRPRMPKRQRIPPVVQLCKEMMPDIRTIGESVKAFEDDIKFLSEAIMNEYGHEDYFNNALLSTLNAVVVEQPQKQAAIALLTMVVNSKNNVAGKSIINYFFEELQKWCKQTYNDEFKSTSNETGPWNKIKLILRFLSILSPMFLVDELINIYKSLFELSIELNNLDPGNRVPLSEAIYTNTLLNIPYLFFFNRNNDGLRTKVEELLAYVEQNYLVKTTDINLLREYNGEPPYEMVELVRVVLPNVKKALINNLEQLNELFPDWNHLLTPQTGDEGFNDALTLPSVDDLKSFVRLNKNFGSVDSMWKTPRYAFHVYLPNSAGNFETVVPISTYAGQLFNDIIIDLVESLEFNRKEVARQVITLDLFFKAGIFTEPGESIAQLIATYEENPLAPTFKIEDLAIETILGLIFKLPSVSQPFAYFYTLLVDICQNSPKAIAPVFGRAFRFFYSHLDSLDFELKLRYLDWFSIQMSNFNFSWKWNEWEDDSIKFGKYFYNPKVNFAKNLIQKELRLTSNFSEVEDSLPQEFTKYLDTSYIPRDQLINYYQSLFTGYTVEEDSVRKNDLYFRQEGVPMENTVRKILDYTHKANNSREVTELESILGELKNEYGSIISDFNRFVIILLVQAVTDSGSRSLSHANKYINDLKEDLKTIFAKIELDIETKEYIIIEAVLTFWNANPQTGFLVADAFKYAGLLTSRTIFTFIFNETGLKNNGLIEATAIEAVFRNLSQQISEENESGNNFEFVFERLCTIANSTIDLLDVNADEDIEIPKVNGEMDIDDIEDDKLDLKWKYFTVIGFIKSILRRYSHEYRELADKFIANIDNAIPHESTRRTISNWIQETKEV
What is the function of this protein?
Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs.  The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation.  Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus.  The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation.  Affects replication of the positive-strand RNA virus BMV.
What are the official names of this protein?
Nuclear cap-binding protein complex subunit 1, 80 kDa nuclear cap-binding protein, CBP80, NCBP 80 kDa subunit, Glycolysis regulation protein 3, Protein SUT1, Suppressor of TOP1 protein.
What is the protein family that this protein belongs to?
Belongs to the NCBP1 family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, perinuclear region. Note=Predominantly nuclear, is able to exit the nucleus in an RNA-dependent manner.
Protein: VLDW_STRHL
Sequence: MTGSVPIVDLEAWRAADEENRASLAEIIDGALHTVGTFLLAGHGVPAELTARMRTAGRSFFDLPWEKKEPHAVQRPHDNGWRGLVKHRTDTIEGTGGAPDLHEAFHMGPTHRTGDDAFDALYYPANKWPAELPELRETALAYTAHMTRVAGAVMEMLAGVLGLEPAFFTSRCEHATWTQSVNWYPSLDTVGQTAEGQMRVGPHTDFGTITLLDRQQGVSGLEVWSEEDGWFAPPFVEGTLLVNLGDLMHQWTDGRWRSLRHRVLAPSASAPQEELVSLVYFFDADPEAELVPLAAPVGGGAGMPTVNVGETILKKNIQMLTDLKGHGLFQGELSLSRPGSADSPGSSPADDHPSRPGRHPAQGPQ
What is the function of this protein?
Involved in the biosynthesis of validamycin B, a component of the antifungal and antibiotic validamycin complex used as a crop protectant.  Catalyzes the regioselective hydroxylation of validamycin A (4-O-beta-D-glucopyranosyl-validoxylamine A) at the C-6 position to yield validamycin B.  To a lesser extent, also able to convert validoxylamine A to its hydroxylated derivative.
What are the official names of this protein?
Validamycin A dioxygenase, Alpha-ketoglutarate/Fe(II)-dependent dioxygenase VldW, Validamycin B synthase.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: CINA_STRR6
Sequence: MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEVRLLSLLEIASQRSSLVILTGGLGATEDDLTKQTLAKFLGKALVFDPQAQEKLDIFFALRPDYARTPNNERQAQIVEGAIPLPNETGLAVGGKLEVDGVTYVVLPGPPSELKPMVLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILADLIDNQIDPTLAPYAKTGEVTLRLSTKASSQEEANQALDILENQILDCQTFEGISLRDFCYGYGEETSLASIVVEELKRQGKTIAAAESLTAGLFQATVANFSGVSSIFEGGFVTYSLEEKSRMLDIPAKNLEEHGVVSEFTAQKMAEQARSKTQSDFGISLTGVAGPDSLEGHPVGTVFIGLAQDQGTEVIKVNIGGRSRADVRHIAVMHAFNLVRKALLSD
What are the official names of this protein?
Putative competence-damage inducible protein.
What is the protein family that this protein belongs to?
Belongs to the CinA family.
Protein: RL25_CHLL2
Sequence: METIALGVEPRVIRKKEAAKLRKNGIVPAVIYHKGEETVAVSVNEIALNKLVHSAESHIIDLQFPDGKTLRSFIKDVQFDPVSDRIIHTDFQLFAADEVVEMEVPVAISGDSIGVEKGGKILILRHALTIQGLPANMPDHVTIDVTNLDMGHIIHVREIPMDAYTGLSIMDEPETPVISIAPPKKDAEAETESAAG
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.