PharMolix/UniProtQA huggingface dataset:
Protein: COX3_BRAFL
Sequence: MTGYQPHPWHLVEPSPWPLVGGSAAFTLTVGLVMWFHYNSISLMILGLVMIVATMIQWWRDVIREATFQGCHTSYVLSGLRRGMVLFIVSEVFFFLAFFWAFFHSSLAPTVELGVTWPPVGVHPLNAFAVPLLNTAVLLSSGVTVTWAHHALMEGKRTEAIQSLAITVMLGLYFTGLQAWEYYEAPFTIADSVYGSTFFVATGFHGLHVIIGSTFLMVCLGRQVFYHYTSSHHFGFEAAAWYWHFVDVVWLFLYVCIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SMC4_SCHPO
Sequence: MSDKGIFRTSSTPSIVDVTPDRGERPRKLVRSVLESPSQKDVASIVKIEQTPSRPFFNDFLKKRITDSLNERPNLLNKFMSAQDGTPSKSTGFNERSSQLVSEFTTTEDIENCEETTQVLPPRLVVYELRLTNFKSYAGTQIVGPFHPSFSSIVGPNGSGKSNVIDALLFVFGFRASKLRQSKASALIHKSATHPSLDSCDVEITFKEVNSDFTYVDGSELTVRRTAYKNNTSKYFVNGVESSFSAVSNLLKEKGIDLNHKRFLILQGEVESIAQMKPRAISEGDDGLLEYLEDIIGTSKYKPIIEENMQELSNSDDICAEKESRLKLVLSEKAKLEDSKNSVLSFLKDENELFMKQNQLYRTILYETRNKKTLVQNLLNSLEGKLQAHLEKFEQTERDISEKNEEVKSLREKAAKVKNDCTSEKKTRQSYEQQTVKIEEQLKFLLNKEKKLKKSIEALSFEKSEAENSLSSHDIDSQKLNSEIADLSLRLQQEELSLDDIRKSLQGKTEGISNAIEEKQKAMAPALEKINQLTSEKQILQVELDMLLNKENDLINDVESSQSSLDKLRNDAEENRNILSSKLKVLSDLKGEKKDVSKNIERKKETVHNTYRNLMSNRTKLEEMKASLSSSRSRGNVLESLQRLHESDNLNGFFGRLGDLATIDEAYDVAISTACPALNHIVVDNIETGQKCVAFLRSNNLGRASFIILKELAQKNLARIQTPENVPRLFDLLRFNDQKFAPAFYNVLQNTLVAKNLEQANRIAYGKTRWRVVTLSGQLIDKSGTMTGGGTRVKKGGMSSAITSDVSPASVETCDKQVQLEDTRYRQHLSELESLNQRFTEISERIPSAELEISKLQLDVSACDRLVAGEERRILQLKSDLKSIRNNNERKRNLQNKISNMDKEVEAININNEGLVTEIKTLQDKIMEIGGIRYRIQKSKVDDLHEQLKFVKDKLNKMSFKKKKNEQRSQSFQVELSNLTSEYDTTTESIATLKTELQSLNKYVDEHKSRLREFENALWDINSSIDELVKFIEFESKQMNSVKAERIELENQIQEQRTALSEVGNNENKYLKLMSNLKLHNLTEFCDQTTMDSTFPEYSEDELSSVDKSELVSNISVLKKKTEDREVDINVLSEYRRCNKEAEKRDSDYQSELQKRTDLKKVVTDLQSQRLDEFMYGFGIISMKLKEMYQIITMGGNAELELVDSLDPFSEGVLFSVMPPKKSWKNISNLSGGEKTLSSLALVFALHNYKPTPLYVMDEIDAALDFKNVSIVANYIKERTKNAQFIVISLRSNMFELSSRLVGIYKTANMTKSVTINNKEILTD
What is the function of this protein?
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.  The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
What are the official names of this protein?
Structural maintenance of chromosomes protein 4, Cell untimely torn protein 3, Chromosome segregation protein cut3.
What is the protein family that this protein belongs to?
Belongs to the SMC family. SMC4 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, condensin associates with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
Protein: RL10_CLOAB
Sequence: MVNKNRQLKEQKVAEIKEKMGKTEAMIMVKYQGLNVEEDTELRKALREAGVEYRVYKNSLAVRAINELGYEGIAQYLEGPIAIAMSYDDPTAPARIINDFAKTHKALELVAGYVQGEVFDVNKVKELASVPAKEVLIAKLLGSFKAPLSNFAYLLSAIKDKKEAEEQA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: SYH_LEPBJ
Sequence: MENQKNFLTTAPYKGTRDFYPEEMRLRNWMFSIMRETVLSFGYEEYDGPILESFDLYKAKSGEEIVERQLYDFIDKGERRVAIRPEMTPTLARMVAGNLRNLPRPVRWFSIPNLWRYEQPGKGRLREHWQLNVDLFGVDTHRAELEILLMADSILKKFGAPTGSYQIKVSHRKLLDSFLKNSLKLSDHQVHGVSKLLDKKSKISPETFEAEIKPLLNNFNEQFSLIETYLASNLETVSTIPGIDPDSIHFIRNLFQELGELGIDKQLVFDPSIIRGFDYYTGCIFEVFDTNPENRRSLYGGGRYDNLIGLFSKEQLSGIGFGLGDVTLKSFLENHNLIPDLSREKTLFLPIMDESIFVDTFKLSKELRENGILTETMLDSAKIGKQIQVAEKKGYRYVLFLGESEIRTETVQIKDLVSGEQKSLPRKGLSDILKKDFRL
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIBB_CITK8
Sequence: MNQTLLSSFGTPFERVEHALSALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMALTIRHGSGIVCLCITEDRRKQLDLPMMVENNTSAYGTGFTVTIEAAKGVTTGVSAADRVTTVRAAIADGAKPADLHRPGHVFPLRAQPGGVLTRGGHTEATIDLVTLAGFKPAGVLCELTNDDGTMARAPECIAFAGKHNMAVVTIEDLVAYRQAHERKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: SUB7B_COCP7
Sequence: MGFIKTLSLSLAAASAANAAKILSPSRPDDVIPNQYIVVMKDGVSGEAFGSHRAWVSDMHHTNLTRRALLNHGIKKTYDFMRMKGYSGVFDRDTIKDISQSPDVAFIEHDHVVRLTELVEQPDAPTWGLGRVSHQEPGNMDYVYDDTAGDGVWAYDIDTGVDIEHPDFEGRAVWGSNHVDDDDTDGNGHGTHVGGTIGSLTYGVAKKVRIIAVKVLDARGSGSNSGVIAGIDWSVNHAMENNVAERAVINLSLGGARSDTTNMAVANAVQAGLHVAVAAGNDNEDAENSSPASEPTVCTVAASNINDQKASFSNFGSVVDIYAPGEEILSLAPGGGTQTLSGTSMAAPHIAGMGAYLIALENITASAACDRIKELGLEVINNPGAGTTNKLTYNGNGQ
What is the function of this protein?
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
What are the official names of this protein?
Subtilisin-like protease CPC735_015300.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL15_WIGBR
Sequence: MYLNTISPMKKSNHSSKRKGRGIGSGKGKTSGRGHKGQRSRSGGKVRRGFEGGQMPLYRRLPKFGHNKSKKSFFKKEIKLSEFMKIKDSFIDLIVLKKNKIINSKIKIVKIIFSKNFNKKINIKNLKVSKNAKKEIEFFGGTIN
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: BGAL_ACTPL
Sequence: MILPNYFQDPNTLHVNTVEHHAYFIPHQQNETALSGKREQSDYFTLLNGQWDFNYFQSYHDLPDNFLDIAFEHKIPVPANWQNHGFDHHHYTNINYPFPFEPPFVPHQNPCGVYHRTLQLTPKHKRYLLNFEGVDSCLFVYVNKQFVGYSQISHNTSEFDVSDYLQAGTNHLTVVVLKWCDGSYLEDQDKFRMSGIFRDVYLLEREQNYLQDFFIQYELDDELRHANLKVETLFSRQPQAIEYQLLNPNGFTVFNQTDTHLNIEVEDIQLWNAEKPQLYTLILHTAEEVIVQKIGFRKVEIKDGILLFNQQPIKFKGVNRHDSDPKTGYAITYAQAHKDLQLMKQHNINAIRTAHYPNAPWFSELCDQYGFYLIGESDVESHGASMLTVKMPEPSILLNHQNDLQTERIRQDMIDNYCYFARDPLFKKAILDRQQANVERDKNRTSIIIWSLGNEAGYGANFEAAAAWIKQRDKSRLVHYESSIYQHSADNNDLSNLDFYSEMYGSTEDIDRYCATAQRKPFVLCEYSHAMGNSNGDAEDYWQAFHRHPQSCGGFVWEWCDHAPYRANGQFGYGGDFGESPHDGNFCMDGLVSPDRIPHSNLLELKNVNRPARAELIDNQIVIHNYLDFTDLADYLTIDYEFVENGVVTSGGNLSVSCKPHSSVILPIELPKNNGHLWLLNLDYRLNTATELLEAEHSLGFEQLNLFSENKLVLPKFTIEKSTFEVQEDHFRINVHNGQFSYQLDKQKGIFSRIEKAGKAIIQQPLDFNIWRAPTDNDRLIREAWQNAGYDKAYTRAYEIQWQQSEQAVEFSVKSAIVSISRGRILTLDIRYRIFNDGQISVEINAIRPTELPYLPRFGLRFWLAKAENTVEYFGYGEQESYVDKHHLANLGIYHTTAKQNHTDYVKPQENGSHYGCEYLKSENLFVSASQPFSFNLSPYTQEELTEKKHYYELQESDYSVLCIDYKMSGIGSNSCGPNLKDQYRLMESEFKIRFDLIFDKTIRQ
What are the official names of this protein?
Beta-galactosidase, Beta-gal, Lactase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
Protein: AMPP3_ASPFN
Sequence: MATVDDILTGKYPAKSHARRVAQLLQAHHGQGAPGVIYLEAQKTRLIEDNDEPMPFRQRRFFYYLSGCSLPDSYLIYDINADKLTLFIPPIDAEEVIWSGLPLSADEAMKLYDVDCVLAATEVNATLRSIGSAYGGNAVAFAIADQVSSGAEFQGFAETKLSVLKEAIEKARVVKDEYEIALLRKANDISAKAHIAAIRASKTAVNEREIEGAFIATCIAHGAREQSYHPIVACGANGATLHYGKNDDDLTDPATKQRKNNILIDAGGEYRAYCSDITRVFPLGGSFTKETRQIYEIVLQMQLECIAMLKGDVQWEDVHAHAHRVAIKGLLALGILSGSEDELFEKRISVAFFPHGLGHYLGMDTHDTGGNPNYGDKDTMFKYLRVRGRLPVGSVITVEPGIYFCRFIIDPYTQSPELGKYINTTVLERYWMVGGVRIEDNIHITKDGHENLTTAPKAIEEMESLAL
What is the function of this protein?
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
What are the official names of this protein?
Probable Xaa-Pro aminopeptidase pepP, Aminoacylproline aminopeptidase, Prolidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24B family.
Protein: RNH2_TREDE
Sequence: MLCGIDEAGRGPLAGPVTAAAVILPSSFDFSILKDSKKLTEKKREEVRKTIYADPNVIWAIGWASNYEIDEINILQATFLAMERAYEGLYLKLQEFCKLNNDKFIEPDIIVDGNFIPNIKNCSSIKALVKADDSVYEVMAASILAKTARDRMMIRYSWIYPEYGYEKHKGYGTKKHIEAIRFNGYSPIQRRSFFVKNL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHL1_BACCE
Sequence: MKGKLLKGVLSFGIGLGVLYGGSSVQADTSTDQNNTLKVMTHNVYMLSTNLYPNWGQSQRADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSNGNEWDKTLGSYSSSTPEDGGVAIVSKWPIVEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNDEYVLFGGDMNVNKINAENNSDSEYASMFKTLHASIPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSFIENKVLQPKSPQWTVTSWLKKYTYDDYSDHYPVAATISMK
What is the function of this protein?
Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
What are the official names of this protein?
Sphingomyelinase C, SMase, Cereolysin B, SMPLC, Sphingomyelin phosphodiesterase.
What is the protein family that this protein belongs to?
Belongs to the neutral sphingomyelinase family.
What are the subcellular locations of this protein?
Secreted.
Protein: ORN_CAEEL
Sequence: MSTLYHTCDKIEQRIIWIDCEMTGLDVEKQTLCEIALIVTDSELNTIATGPDIVIHQPKEVLDNMEEWPRNTFHENGLMEKIIASKYSMADAENEVIDFLKLHALPGKSPIAGNSIYMDRLFIKKYMPKLDKFAHYRCIDVSTIKGLVQRWYPDYKHPKKQCTHRAFDDIMESIAELKNYRESIFVKSTASSF
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Probable oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
Protein: RL9_CLOBM
Sequence: MKVILLKDVKSLGKKGDLVNASDGYARNYLIPKKLAEQATENNVHILNNKKEAERRQKLKELEEAQKLAKSLMGKEIKFKVKIGENGRLFGSITSKDISEKLKEQYNMDIDKKKIVAETIRQTGVYEAEIKIYPEVSTKVKVSVLEE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: RM11_MOUSE
Sequence: MSKLSRATRTLKKPEAGGVIRSIVRAGQAIPGPPLGPILGQRGVSINQFCKEFNEKTKDIKEGIPLPTKIFIKPDRTFELKIGQPTVSYFLKAAAGIEKGARHTGKEVAGLVSLKHVYEIACVKAKDDAFAMQDVPLSSVVRSIIGSARSLGIRVVKDLSAEELEAFQKERAVFLAAQKEADLAAQAEAAKK
What are the official names of this protein?
39S ribosomal protein L11, mitochondrial, L11mt, MRP-L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: RS20_PROM3
Sequence: MANNKSSKKRVQIAERNRLENKSYKSAMRTLMKRCFSACSNYSQQPGETAKANVKASIDSAFSKIDKAVKRGVLHRNTAAHQKSRLSAAVKQAIEPAPST
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: MK67I_DANRE
Sequence: MTEGKSSDKPAKRLLALNPKEDAEFQKKVQQVKKRPQTGQTLSPGVLYVGHLPRGLFEPQLKSYFEQFGKVLRLRVSRSKKTGGSKGYGFVEFECDEVAKIVAETMNNYLMGERIIKCHVIPPEKVHEKLFVGSIAGFKKPKYPAVTRYNKTHTEDDVKKVGTKLLSKESKLRKRLAAKGIDYDFPGFAAQIPAKKAPSEANVSVCSEDVTPVCTPSLLERRKSLRVEDDDVDDEIVIKVKPLPENSDDVEESEEESAEEDEGEEEEAA
What is the function of this protein?
Plays an essential role in early embryonic development.
What are the official names of this protein?
MKI67 FHA domain-interacting nucleolar phosphoprotein, Nucleolar phosphoprotein NOPP34-like protein.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: MQO_SODGM
Sequence: MKENFIAALGMTVSASAKQHQVVDNPPVDIILIGGGVMSATLGTYLKALEPGWTIHMYERLEKTAEESSNGWNNAGTGHAAFCELNYTTLSPAGSVDISKAVAVNESFEISRQFWAYLVKQKILTNPQSFINNVPHMSFVWGEDNIRFLRQRFDALQTSTLFRGMEYSENPQQIREWAPLVMDGRDTFQKVAATRMAMGTDVNFGEMTQQLLAALQQYPQFHLHLQHDVVDIKRNADQTWSVRVADHSNGGRQSTVCARHVFIGGGGASLTLLQKSGIPEVNGYAGFPVGGQFLVATNPEVVGHHHAKVYGKASVGAPPMSVPHIDTRILDGKQALLFGPFATFSSKFLKRGSWLDLFHSLTRQNLLPMLRVGLDNFGLMRYLIGQLLMSDKDRLNALREYYPQATMADWSLIEAGQRVQVIKKDAGKGGILQFGTEVVSSADGSLSVLLGASPGASTAAPIMLELLASMFKEQVTTDAWQRKLKEMVPSYGQTINGNLALTNEIRLSTSEVLGLTYIEAKPLPGEPADGKWEGLQKAM
What are the official names of this protein?
Probable malate:quinone oxidoreductase, MQO, Malate dehydrogenase [quinone].
What is the protein family that this protein belongs to?
Belongs to the MQO family.
Protein: Y609_HELPJ
Sequence: MEKLPKKRVSKTKSQKLIHSLTTQKNRAFLKKISANEMLLELEKGAFKKNEAYFISDEEDKNYVLVPDNVISLLAENARKAFEARLRAELERDIITQAPIDFEDVREVSLQLLENLRQKDGNLPNINTLNFVKQIKKEHPNLFFNFDNMFKQPPFNENNFENFDNSDEENF
What are the official names of this protein?
UPF0763 protein jhp_0609.
What is the protein family that this protein belongs to?
Belongs to the UPF0763 family.
Protein: EX7S_YERE8
Sequence: MPKKAASPETKAASFETSLSELEQIVTRLESGELPLEEALNEFERGVQLARIGQQTLLQAEQRVQVLLSDDVDAPLTPFTPDTE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y947_ARCFU
Sequence: MRRRRYLEKLEWVEREINFATEHAMSDEVRKRAVLYSIMTAVEVVMDIVAMLVKDLGKQVEDDYTNISKLLEECVIEESEAELLRRYNGLRNAIAHHYNHLDLSKVERALTQLDELYEVAVKLVKTADKLAG
What is the function of this protein?
Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase.  Probably neutralized by cognate antitoxin AF_0948.  Neutralization may be due to AMPylation by AF_0948.
What are the official names of this protein?
Putative RNase AF_0947, Putative toxin AF_0947.
What is the protein family that this protein belongs to?
Belongs to the HepT RNase toxin family.
Protein: ILVC_JANSC
Sequence: MRVYYDRDCDVNLIKDMKVAILGYGSQGHAHALNLRDSGAKNVVVALREGSASAAKAEGEGLKVMGIAEAAAWCDVIMFTMPDELQAETYKKYVHDNLKDGAAIAFAHGLNVHFGLIEPKPGVDVIMMAPKGPGHTVRGEYTKGGGVPCLVAVHQNASDRALEIGLSYCSAIGGGRSGIIETNFREECETDLFGEQAVLCGGLVELIRMGFETLVEAGYAPEMAYFECLHEVKLIVDLIYEGGIANMNYSISNTAEYGEYVSGPRILPYDETKARMKAVLRDIQTGAFVRDFMQENQAGQPYFKGTRRLNDEHQIEQVGETLRGMMPWISEGKMVDKAKN
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: RNZ_THEAC
Sequence: MASNIRIIFYGTGGSWPTPLRAMPGVGVKIDDVLNLFDCGEGTQKQIMKSSTSFMDIDNIFITHFHGDHFLGLLGLVQSMSFNNRTKQLNIFGPHGAIKILSNALNVGYYTLHFPLKIYELEPDRTYDLGKFLIRTMLNDHPVPALSYSIEERDLVRIDPEKAREKNIPSRIIEKIRENGSYVYKGNEYRIDDIAGGVRKGRRIVYTGDTRPMDRMIEFARNADVLIHDTTTDSSFEPMVNEFGHSSSRQAARIARQARVGRLYLYHYSPRITDTSVLLEDARKEFQETYESKDLMEYEVKVRRDVD
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: SCTN_SHISO
Sequence: MSYTKLLTQLSFPNRISGPILETSLSDVSIGEICNIQAGIESNEIVARAQVVGFHDEKTILSLIGNSRGLSRQTLIKPTAQFLHTQVGRGLLGAVVNPLGEVTDKFAVTDNSEILYRPVDNAPPLYSERAAIEKPFLTGIKVIDSLLTCGEGQRMGIFASAGCGKTFLMNMLIEHSGADIYVIGLIGERGREVTETVDYLKNSEKKSRCVLVYATSDYSSVDRCNAAYIATAIAEFFRTEGHKVALFIDSLTRYARALRDVALAAGESPARRGYPVSVFDSLPRLLERPGKLKAGGSITAFYTVLLEDDDFADPLAEEVRSILDGHIYLSRNLAQKGQFPAIDSLKSISRVFTQVVDEKHRIMAAAFRELLSEIEELRTIIDFGEYKPGENASQDKIYNKISVVESFLKQDYRLGFTYEQTMELIGETIR
What is the function of this protein?
ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (By similarity).  Acts as a molecular motor to provide the energy that is required for the export of proteins (By similarity).  Required for type III secretion apparatus (T3SA) formation, proper protein secretion, host cell invasion and virulence (By similarity).  May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (By similarity).
What are the official names of this protein?
Type 3 secretion system ATPase, T3SS ATPase.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPIA_ECOLI
Sequence: MFKSTLAAMAAVFALSALSPAAMAAKGDPHVLLTTSAGNIELELDKQKAPVSVQNFVDYVNSGFYNNTTFHRVIPGFMIQGGGFTEQMQQKKPNPPIKNEADNGLRNTRGTIAMARTADKDSATSQFFINVADNAFLDHGQRDFGYAVFGKVVKGMDVADKISQVPTHDVGPYQNVPSKPVVILSAKVLP
What is the function of this protein?
PPIases accelerate the folding of proteins (Probable).  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:2190212).
What are the official names of this protein?
Peptidyl-prolyl cis-trans isomerase A, PPIase A, Cyclophilin A, Rotamase A.
What is the protein family that this protein belongs to?
Belongs to the cyclophilin-type PPIase family.
What are the subcellular locations of this protein?
Periplasm.
Protein: DGCS_SHEON
Sequence: MDFGLATTLYPDEYNYQTDAYSPTSSPVDLVQVIQQLHASLDPRTVFACYGKVLGQHLPIQGVRLQSEQHKLSWGKRYGISLKRQIICGGTPLTLQYQLLTPLTPSQSICLQEIEPLLLQPLLNAMQYQEMSMQAMFDALTGLGNRHYYSQSLKNAVARAQRKQGSVSLIVLDLDNFKKLNDKYGHKCGDYILKEFGDIIRSSIRSTDQAFRIGGDEFVVIVQGNIHAAGLLCERIVSATNTHASFHQFGVSCSLGAAEASETMEAEQLYEQADKTLYQAKASGRNCYKLSPTQLS
What is the function of this protein?
Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (PubMed:33637573).  May be involved in the regulation of formation of solid surface-associated biofilms and pellicles according to environmental conditions (PubMed:33637573).
What are the official names of this protein?
Diguanylate cyclase DgcS, DGC.
Protein: RPIA_SHISS
Sequence: MTQDELKKAVGWAALQYVQPGTIVGVGTGSTAAHFIDALGTMKGQIEGAVSSSDASTEKLKSLGIHVFDLNEVDSLGIYVDGADEINGHMQMIKGGGAALTREKIIASVAEKFICIADASKQVDILGKFPLPVEVIPMARSAVARQLVKLGGRPEYRQGVVTDNGNVILDVHGMEILDPIAMENAINAIPGVVTVGLFANRGADVALIGTPDGVKTIVK
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: RS20_SYNS9
Sequence: MANNNSAKKRIEIAERNRLRNRTYKSSMRTLMKRCFSACDAYGSAPGEEAKASVQASLREAFSKIDKAVKVGVLHRNNGANQKSRLSSAVRKVLEPTS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: PG12A_HUMAN
Sequence: MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL
What is the function of this protein?
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.  Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.
What are the official names of this protein?
Group XIIA secretory phospholipase A2, GXII sPLA2, sPLA2-XII, Phosphatidylcholine 2-acylhydrolase 12A.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
Protein: RRF_BURCJ
Sequence: MSVADVKKGVEQKMQRSIEAFKNDLAKIRTGRAHTGLLDHVQVDYYGSMVPISQVANLTLVDARTIGVQPWEKNMVAKVEKAIREADLGLNPATAGDLIRVPMPALTEERRRELTKVVKSEGETAKVAIRNLRRDANEALKKLVKDKEISEDDERRASDDVQKLTDKHVAEVDKLVQTKEAEIMTV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ACTS_PIG
Sequence: MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
What is the function of this protein?
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
What are the official names of this protein?
Actin, alpha skeletal muscle, Alpha-actin-1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: GLPE_ECOSM
Sequence: MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAAQAFHLTNDTLGAFMRDNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.