PharMolix/UniProtQA huggingface dataset:
Protein: KAE1B_METAC
Sequence: MKNTFILGIEGTAWNLSAAIVTETEIIAEVTETYKPEVGGIHPREAAQHHAKYAASVIKRLLAEAKEKGVEPSDLDGIAFSQGPGLGPCLRTIATAARMLSLSLDIPLIGVNHCIAHIEIGIWRTPARDPVVLYVSGANSQVISFMEGRYRVFGETLDIGLGNALDKFARRAGLPHPGGPKIEACAKDAKRYIPLPYVIKGMDLSFSGLSTASSEALKKASLEDVCYSYQETAFAMVVEVAERALAHTGKNEVLLAGGVGANTRLREMLNEMCEARGAKFYVPEKRFMGDNGTMIAYTGLLMYKSGNTLTLEDSRVNPNFRTDDVNVTWIKEEEMKKVPEISPEAFLRAPPGERLDNGAEAVIYLDEGPEGKKVLVKERVPKLYRHKEIDERIRRERNRTEARLISEARRAGVPTPIIYDIEEFKLKMQFIEGVPIKYLITPELSEKVGELVGRLHSSGIVHGDLTTSNLLLAGERLYLIDFGLAYFDKSLEARGVDVHVLFQTFESTHRGHETLVKAFEKGYGSTFIDSKDVLKRVEEIKKRARYA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  The Kae1 domain likely plays a direct catalytic role in this reaction.  The Bud32 domain probably displays kinase activity that regulates Kae1 function.
What are the official names of this protein?
Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URK_CHLSY
Sequence: MSTYPIIIGVAGGSASGKTSVAQAILQRVGADRIAHIDHDRYYKDLSHLPLEERAKFNFDHPDALDNDLLVAHLDALCAGQSVDLPTYDYATYVRLPQTERIEPRPVILVEGILIFYEPVLRRRMQIKLFVDTDADLRFIRRLRRDIVERGRSVESVIEQYLATVRPMHLEFVEPTKRYADVIFPGGGRNPIAIDMVVARIEAALQATP
What are the official names of this protein?
Uridine kinase, Cytidine monophosphokinase, Uridine monophosphokinase.
What is the protein family that this protein belongs to?
Belongs to the uridine kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNW_BACMK
Sequence: MNENHYLLLTPGPLTTTKTVKEVMLYDWCTWDVEYNTMVQDVRNRLVSLATKEEEKYTTVLMQGSGTFSVEAVIGSVIPRKGKLLVCTNGAYGKRIVQMAEMLHIDVVVSQTEEWEPTNIAEVEQLLQQDKEITHIVVVHCETTTGIINPIVDVCKLGKKYGKVTLVDAMSSFGGIEIDIAELQIDFLISSANKCIQGVPGFGFVIANRDELLKCKGQARSLSLDLYDQWETMEEQNGKWRFTSPTHVVHAFYQALLELEEEGGVRARYNRYYSNQKLLVHKMKEMGFKPLVDEKYQSPIITSFIYPEAGFEFLQLYNELKRYGFVIYPGKISKVDTFRIGNIGDVHEDDINRLVDSIAKGVVIG
What is the function of this protein?
Involved in phosphonate degradation.
What are the official names of this protein?
2-aminoethylphosphonate--pyruvate transaminase, 2-aminoethylphosphonate aminotransferase, AEP transaminase, AEPT.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.
Protein: NKTR_MOUSE
Sequence: MGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFILKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDGVHVVFGLVISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKLTKDVFEKKRKKPTCSEGSDSSSRSSSSSESSSESEVERETIRRRRHKRRPKVRHAKKRRKEMSSSEEPRRKRTVSPEGYSERSDVNEKRSVDSNTKREKPVVRPEEIPPVPENRFLLRRDMPAITVEPEQNIPDVAPVVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSHSESKDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSDGHHKKHRKEKKFKHKKKAKKQKHCRRHRQTKKRRIVMPDLEPSRSPTHRMKSSCVRERRSRASSSSSHHSSKRDWSKSDQDDGSASTHSSRDSYRSKSHSRSDSRGSSRSRAVSKSSSRSLNRSKSRSSSRSGPRRTSISPKKPAQLSENKPVKTEPLRPSVPQNGNVLVQPVAAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPVQSTYSLTNIKATVSSSSYHKREKPSESDGSAYSKYSDRSSGSSGRSGSKSSRSRSSSRSYTRSRSRSLPTSRSLSRSPSSRSHSPNKYSDGSQHSRSSSYTSVSSDDGRRAMFRSNRKKSVTSHKRHRSNSEKTLHSKYVRGREKSSRHRKYSESRSSLDYSSDSDQSHVQVYSAPEKEKQGKVEALNDKQGKGREEGKPKPEWECPRSKKRTPKDHSRDDSVSKGKNCAGSKWDSESNSEQDVTKSRKSDPRRGSEKEEGEASSDSESEVGQSHIKAKPPAKPPTSTFLPGSDGAWKSRRPQSSASESESSCSNLGNIRGEPQKQKHSKDDLKGDHTKRAREKSKAKKDKKHKAPKRKQAFHWQPPLEFGDDEEEEMNGKQVTQDPKEKRHVSEKCEAVKDGIPNVEKTCDEGSSPSKPKKGTLEQDPLAEGGHDPSSCPAPLKVEDNTASSPPSAQHLEEHGPGGGEDVLQTDDNMEICTPDRTSPAKGEVVSPLANHRLDSPEVNIIPEQDECMAHPRAGGEQESSMSESKTLGESGVKQDSSTSVTSPVETSGKKEGAEKSQMNLTDKWKPLQGVGNLSVSTATTSSALDVKALSTVPEVKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDDQTPSRDGDSQSRSPHRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRDWYSRGRTRSRSSSYGSFHSHRTSSRSRSRSSSYDLHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSGRSYGSDSESDRSYSHHRSPSESSRYS
What is the function of this protein?
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.  Component of a putative tumor-recognition complex involved in the function of NK cells.
What are the official names of this protein?
NK-tumor recognition protein, NK-TR protein, Natural-killer cells cyclophilin-related protein, Peptidyl-prolyl cis-trans isomerase NKTR, PPIase.
What are the subcellular locations of this protein?
Cell membrane.
Protein: NCAP_I53A0
Sequence: MASQGTKRSYEQMETGGERQNATEIRASVGRMVGGIGRFYIQMCTELKLSDYEGRLIQNSITIERMILSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRRDGKWMRELILYDKEEIRRIWRQANNGEDATAGLTHLMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRAMMDQVRESRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGIDPFRLLQNSQVFSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTRVVPRGQMSTRGVQIASNENMETMDSSTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATIMAAFTGNTEGRTSDMRTEIIRMMENARPEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDN
What is the function of this protein?
Encapsidates the negative strand viral RNA, protecting it from nucleases.  The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication.  The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex.  NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway.  Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins.  It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export.  M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals.  Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein.  Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
What are the official names of this protein?
Nucleoprotein, Nucleocapsid protein, Protein N.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses nucleoprotein family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: IPA14_SHIFL
Sequence: MIKSTNIQAIGSGIMHQINNVYSLTPLSLPMELTPSCNEFYLKTWSEWEKNGTPGEQRNIAFNRLKICLQNQEAELNLSELDLKTLPDLPPQITTLEIRKNLLTHLPDLPPMLKVIHAQFNQLESLPALPETLEELNAGDNKIKELPFLPENLTHLRVHNNRLHILPLLPPELKLLVVSGNRLDSIPPFPDKLEGLALANNFIEQLPELPFSMNRAVLMNNNLTTLPESVLRLAQNAFVNVAGNPLSGHTMRTLQQITTGPDYSGPQIFFSMGNSATISAPEHSLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYSQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLSENGSNHIA
What is the function of this protein?
E3 ubiquitin-protein ligase effector that inhibits host cell innate immunity during bacterial infection by catalyzing 'Lys-48'-linked polyubiquitination and subsequent degradation of host RNF31/HOIP (PubMed:27572974).  Host RNF31/HOIP is the catalytic component of the LUBAC complex, which conjugates linear ('Met-1'-linked) polyubiquitin chains at the surface of bacteria invading the host cytosol to form the ubiquitin coat surrounding bacteria (PubMed:27572974).  The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:27572974, PubMed:28481331).  By promoting degradation of host RNF31/HOIP, IpaH1. 4 prevents formation of the bacterial ubiquitin coat and activation of host cell innate immunity (PubMed:27572974, PubMed:28481331).
What are the official names of this protein?
E3 ubiquitin-protein ligase IpaH1.4.
What is the protein family that this protein belongs to?
Belongs to the LRR-containing bacterial E3 ligase family.
What are the subcellular locations of this protein?
Secreted. Host cytoplasm. Note=Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cytoplasm.
Protein: RL34_BURL3
Sequence: MKRTYQPSVTRRKRTHGFRVRMKTAGGRKVINARRAKGRKRLAI
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: NADK_FLAPJ
Sequence: MKIAVFGQFYQNSTSPIIARLFAFLNQNNIQVVIEEKFAAILIENKSIANTYQKFSSHKDLDKSFEMLISVGGDGTFLRATTLVRNSGIPILGINAGRLGFLATVQQENIETFLQLVLEKKYTISKRTLLSLKCASKIEEIKDLNFAMNEITVSRKDTTSMITIETYLNGEYLNSYWADGLIISTPTGSTGYSMSCGGPILTPEANCLVITPIAPHNLNARPLVIPDNTEIKLKVSGREENYLVSLDSRIASVKNEDILTIKKTPFKINMIEIPEETFLKTLRNKLLWGEDKRN
What is the function of this protein?
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP.  Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
What are the official names of this protein?
NAD kinase, ATP-dependent NAD kinase.
What is the protein family that this protein belongs to?
Belongs to the NAD kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_CLOBK
Sequence: MEDLKVTPLRGVYEEYGGKIVDFAGYELPTQFKGFLHEHHTVREKAGLFDVSHMGEVMVTGKDAGKFIQYLMTNDINILKDNEVLYTFMCNEDGGVIDDLLVYKFAENEFFLVINASNKDKDVKWIMDHKGDFDVEIVDESDSIAQLALQGPLAEEILQKIVDIDLQEIKFFKLKRDVLVNGKKCLVSRTGYTGEDGFEIYCKPEDAKGLWHAILNAGKEEGVQPIGLGARDTLRFEASLLLYGNEMDETITPLEVGMGFFVKLKVEEDFIGKDALIKQKAEGVTRKLVGFELLDKGIPRHGYEVIKDGKVIGHVTTGYKSPTLNKAIGLALVEEQYSKIGTEFNIKVRKKELKAVAIDKRFYTKKTKTK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: GUNC_BUTFI
Sequence: MKKVLVNQVGFLCNAPKKAVLNFQANEFSVVDGNGKKAFDGKVEHFGTDEISGEDTYVADFSALTEEGKYKIVADGQESVLFSISNDAYDKLMKDICKCFYYLRCGDALSKEFAGEYYHKPCHMTKATVYGEDVEPVDVTGGWHDAGDYGRYSTAGAVAVAHLLYGVRFFKGLLDVHYDIPKVAGDKGNLPEILAEVKVELDFLMKMQRENGSVWHKVTTFNHAPFLMPEDDREELFLFSVSSLATADIAAVFALAYTVYKEYDAEYADKLMQKSLLAYKWLLDNPDELLFFNPDGSNTGQYDEAEDISNRFWAACALYEATSDGKYYSDAQELKNRLEEFDKNAQKKGYQGNVFTCLGWAEVAGLGSLSLLLKREENALCSLARNSFVAEADRLVKVSKENGFGLCMGENDFIWGSNMELLKYMMVLSTAIRIDNKPEYKLALEAGLDYILGCNSMDISYVTGNGEKAFKNPHLRPTAVDDIEEPWPGLVSGGPNSGLHDERAQTLRGKGLPPMKCYIDHIDCYSLNEITIYWNSPLVFALSGILE
What is the function of this protein?
Glycoside hydrolase that rapidly hydrolyzes short-chain cellodextrins to yield either cellobiose or cellobiose and glucose as end products; cellobiose is not hydrolyzed further.  Also shows limited activity against endoglucanase specific substrates (carboxymethylcellulose (CMC), lichenan, laminarin and xylan).
What are the official names of this protein?
Cellodextrinase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 9 (cellulase E) family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRHO_FRAT1
Sequence: MGIYMSQIVVCAMYKFVTLEDFEAMRQPLLDTMIKNNVKGTLLLANEGINGTVAGTRESIDNLLAYLKADPRLVDIDYKESYHQEMPFYRSKVKLKKEIVTLGIDEIDPNKICGKYVEPKDWNDLISDPETVLIDTRNEYEIEIGTFKNAINPHTENFREFPQYVDENLDPKKHKKVAMFCTGGIRCEKSTALLKAKGFDEVYHLKGGILKYLEEVPKEKSMWQGECFVFDSRVAVNHDLEKGNYDQCFACRMPITEDDKKRPEYVKGISCHHCYDKVTEKQKARFAEREKQSQLAAEKGFSHVGDEAKKLAQLNKQKKQQAKEAARKKAQQ
What is the function of this protein?
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
What are the official names of this protein?
tRNA uridine(34) hydroxylase, tRNA hydroxylation protein O.
What is the protein family that this protein belongs to?
Belongs to the TrhO family.
Protein: SSPI_BACAN
Sequence: MSFNLRGAVLANVSGNTQDQLQETIVDAIQSGEEKMLPGLGVLFEVIWKNADENEKHEMLETLEQGLKK
What are the official names of this protein?
Small, acid-soluble spore protein I, SASP I.
What is the protein family that this protein belongs to?
Belongs to the SspI family.
What are the subcellular locations of this protein?
Spore core.
Protein: ATP19_YEAST
Sequence: MGAAYHFMGKAIPPHQLAIGTLGLLGLLVVPNPFKSAKPKTVDIKTDNKDEEKFIENYLKKHSEKQDA
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane.  The K chain binds the dimeric form by interacting with the G and E chains.
What are the official names of this protein?
ATP synthase subunit K, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATP19 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: DCUP_HELPG
Sequence: MIFIDACFRKETPYTPIWMMRQAGRYLSEYQESRKKAGSFLELCKNSDLATEVTLQPVEILGVDAAILFSDILVVPLEMGLNLEFIPKKGPHFLETITDLKSVESLKVGAYKQLNYVYDTISQTRQKLSKEKALIGFCGSPWTLATYMIEGEGSKSYAKSKKMLYSEPEILKALLEKLSLELIEYLSLQIQAGVNAVMIFDSWASALEKEAYLKFSWDYLKKISKELKKRYPHIPVILFPKGIGAYLDSIDGEFDVFGVDWGTPLTAAKKILGGKYVLQGNLEPTRLYDKNALEEGVETILKVMGNQGHIFNLGHGMLPDLPRENAKYLVQLVHAKTRR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_WOLPP
Sequence: MTNLLEKFNEQQIQRLAKEMPAFCPGDDLKVTFKVVDSTGERIQIFEGVCISKRNRGLHSSFSVRKVSHGESIVSQFFVYSPALISVQVMRKGKVRRAKLYYLCKLFGKAARIKERTTYVKKKSK
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: DNAK_THEFY
Sequence: MARAVGIDLGTTNSVVAVLEGGEPTVIANAEGARTTPSVVAFAKNGEVLVGEIAKRQAVTNVERTIRSVKRHMGTDWKTHIDGKDFTPQQISAFVLQKLKRDAEAYLGEEVTDAVITVPAYFSDAERQATKDAGKIAGLNVLRIINEPTSAALAYHLEKEGEATILVFDLGGGTFDVSLLDVGDGVVEVKATHGDNHLGGDDWDQAVVDWLVERFKSSNGIDLSKDKMAMQRLREAAEKAKIELSSSTETSINLPYITASAEGPLHLDEKLTRAEFQRLTSHLLERTKGPFFQVIKDAGISVDQIDHVVLVGGSTRMPAVVDLVRELTGGKEPNKGVNPDEVVAVGAALQAGVLKGDVKDVLLLDVTPLSLGIETKGGVFTKLIERNTAIPTKRSEIFTTAEDNQPSVQIQVYQGEREIAKYNKKLGVFDLTGIPPAPRGVPQIEVTFDIDANGIVNVTAKDLGTGKEQSVTITGGSALPKEDIERMIREAEEYAEQDRKRREEAETRNNAESLVYQTEKVISENEDKIPEDVKNETKEALDGLKKALEGSDIEAIRSASEKVALASQKIGSAIYSQSQQASGAAAGGQQNAEDAEVVDAEIVDEEPKREGNS
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: Y1036_HAEIN
Sequence: MELSQTALFIGSIINLNALVLILRAWLQFARVDYYNPVSTFAVKMTDPVLKPLRKIAPTVKNIDTSALLLIFIIGMLKGIIYFGLSVNVLLVLGVLTVLKSIGLAIFYVLFIGAVLSWFNRGNNSISYAFYQLSEPLLKPIRRLLPTLGMIDFSPMVVMFILLFLNNFMLDLLGGLWIIAG
What are the official names of this protein?
Uncharacterized protein HI_1036.
What is the protein family that this protein belongs to?
Belongs to the YggT family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MATRX_PI3B
Sequence: MSITNSAIYTFPESSFSDNGNIEPLPLKVNEQRKAVPHIRVVRIGDPPKHGSRYLDVFLLGFFEMERSKDRYGSVSDLDDDPSYKVCGSGSLPLGLARYTGNDQELLQAATKLDIEVRRTVKATEMIVYTVQNIKPELYPWSSRLRKGMLFDANKVALAPQCLPLDRGIKFRVIFVNCTAIGSITLFKIPKSMALLSLPNTISINLQVHIKTGIQTDSKGVVQILDEKGEKSLNFMVHLGLIKRKMGRMYSVEYCKQKIEKMRLLFSLGLVGGISLHVNATGSISKTLASQLAFKREICYPLMDLNPHLNLVIWASSVEITRVDAIFQPSLPGEFRYYPNIIAKGVGKIRQ
What is the function of this protein?
Plays a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus/respirovirus/rubulavirus M protein family.
What are the subcellular locations of this protein?
Virion.
Protein: PRIO_SIGHI
Sequence: MANLGYWLLALFVATWTDVGLCKKRPKPGGWNTGGSRYPGQGNPGGNRYPPQGGGTWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQYNNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSAVLFSSPPMILLISFLIFLIVG
What is the function of this protein?
Its primary physiological function is unclear.  Has cytoprotective activity against internal or environmental stresses.  May play a role in neuronal development and synaptic plasticity.  May be required for neuronal myelin sheath maintenance.  May play a role in iron uptake and iron homeostasis.  Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).  Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts.  Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
What are the official names of this protein?
Major prion protein, PrP.
What is the protein family that this protein belongs to?
Belongs to the prion family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Protein: PYTD_ASPTN
Sequence: MGLFLNKIVIPGYFSHLRSMVGSLSRGISRKATLEYYAQVADEETAKAVDGWTCKSEAEKSVALFEEISFLVHKIIVRCLMGQDFYDHHVRELYDLLRTMEANVGSIWHTVLPGWVAHGPARRLWRCRQRVQEIFDFRLRERERSPEEWKKRLDYISYTLQDPATAHLSRFYGAHHTLLMFAAHTSTVASISWILLEWKSPHRLQRLREELATHALEQSPFLDALVKETGRHYSGNSDVRWARKPKTLRTEVASVPESRITIPEGTIVSISPYLTHHDPATWDNADTYLPERWLADPDLAKKMNEGGQLRYIPFGAGSHRCPGEKMAILIAKIAVARIVQSCDLAWGEGSSENTLGGLDFSKVGSPWLKGDVQVRFQV
What is the function of this protein?
Cytochrome P450 monooxygenase pytD; part of the gene cluster that mediates the biosynthesis of pyranterreones, a family of antioxidative compounds (PubMed:32077283).  The first step of pyranonigrins biosynthesis is performed by the hybrid PKS-NRPS synthetase pytA that condenses 4 malonyl-CoA units ato the acetyl starter unit by the modular PKS of pytA (PubMed:32077283).  The acyl chain is then connected to an L-serine through the amide bond by the modular NRPS of pytA (PubMed:32077283).  A tetramic acid is formed and released from the PKS-NRPS pytA to give pyranterreone 5 with the help of the thioesterase pytI (PubMed:32077283).  Pyranterreone 5 could be methylated by pytC to afford pyranterreone 6 (Probable).  Both pyranterreones 5 and 6 are subsequently oxidized by the FAD-linked oxidoreductase pytB and the cytochrome P450 monooxygenase pytD to form the fused gamma-pyrone core, resulting in pyranterreones 7 and 11, respectively (PubMed:32077283).  The hydroxy group at C-8 of pyranterreones 7 and 11 are dehydrated by the aspartyl protease pytH to form a delta-7 double bond to give pyranterreones 3 and 1, 2 accordingly (PubMed:32077283).  The exo-methylene of pyranterreone 3 could be reduced into a pendant methyl by reductase pytE to provide pyranterreone 4, also known as cordylactam (Probable).  Pyranterreone 4 can be reconverted to pyranterreone 3 through pytB-catalyzed dehydrogenation or further oxidized to pyranterreones 9 and 10 (Probable).
What are the official names of this protein?
Cytochrome P450 monooxygenase pytD, Pyranterreones biosynthesis cluster protein D.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: YO121_YEAST
Sequence: MFNLSTYYNHTRNTQKQLLEYFERRPIWMYNPFFALFLRYVIDSFKVLSRQSKYFPVRFDSIGIHRFWQDNITSLDVPANNNVSGLNVIFLRNFKDNRFLQ
What are the official names of this protein?
Putative uncharacterized protein YOR121C.
Protein: ANXA1_RODSP
Sequence: MAMVSEFINQACYLEKQEQEYIEIVKSYKGGPAHAVSPYPSFDPSSDVAALHKGIMVNGVDEATILDLLTKRYNAQRHHLKAVYIQETGEPLDETLKKALTGHIQELLLAMIKTPAQFDGNELRAAMKAVGTDEETLIEILWTRSNQQIREITSVYREELKKDIAKYQTSDTSGEFRDALLALAKGNRCEDMSVNQDIADTDARALYQAAERRNGTDVNVFNTILTTKKYPHLRNKFQNYRKYTEEDMKKALDIELKGQIEKCLTTIAKCGTSTPAFFAEKLYEAMKGAGTRHKTLIRIMVSRSEIDSDQIKVFYQKKYGVPLCQAILDETKGAYEKILVALEGGN
What is the function of this protein?
Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades.  Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors.  Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration.  Promotes resolution of inflammation and wound healing.  Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
What are the official names of this protein?
Annexin A1, Annexin I, Annexin-1, Calpactin II, Calpactin-2, Lipocortin I.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium. Basolateral cell membrane. Lateral cell membrane. Cell membrane; Peripheral membrane protein. Apical cell membrane. Membrane; Peripheral membrane protein. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Secreted. Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted, extracellular exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup. Note=Colocalizes with actin fibers at phagocytic cups. Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles. Secretion is increased in response to wounding and inflammation (By similarity). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity). Detected in gelatinase granules in resting neutrophils. Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect. Displays calcium-dependent binding to phospholipid membranes (By similarity).
Protein: YDJC_LISMC
Sequence: MKIIFNADDFGISPGAVYGILESYKRGVVKSTTLLANSPAFDLAVEVAKENPGLDIGAHLTLTFGSPVLQGLETLTDDDGRFRRNYTSLENGLADVDMNEVERELTAQIEKILDAGITISHFDTHHSIEPLIYPVQHKLAEKYGVSIRRHSDVSDFGAIKTPDLFATEFYADGVSFETIKKLVQKHIGTNDVVEVMTHPAFIDETLREISSYVEPRIKEVSILTSRELQAYLGQQEVEIISFRDL
What is the function of this protein?
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
What are the official names of this protein?
Carbohydrate deacetylase.
What is the protein family that this protein belongs to?
Belongs to the YdjC deacetylase family.