PharMolix/UniProtQA huggingface dataset:
Protein: CYTL_IXOSC
Sequence: MTSTFALVLLLGGMAVCVATGVFGGYSERANHQANPEFLNLAHYATSTWSAQQPGKTHFDTVAEVVKVETQVVAGTNYRLTLKVAESTCELTSTYNKDTCLPKADAAHRTCTTVVFENLQGDKSVSPFECEAA
What is the function of this protein?
Inhibitor of cysteine proteinases.  Inhibits host immune responses via its inhibition of host cathepsins (PubMed:19494265).  Contributes to the suppression of the host's immune response to tick salivary proteins and is important for successful feeding on hosts (PubMed:17698852).  Inhibits differentiation of host dendritic cells (PubMed:19494265, PubMed:25975355).  Inhibits proliferation of host T-cells in response to antigen stimulus (PubMed:19494265).  Down-regulates TLR2-mediated host responses to infection by B. burgdorferi and the production of the chemokine CCL3 by host dendritic cells (PubMed:25975355).  Down-regulates host responses to infection by B. burgdorferi and the production of IFNB1 by host dendritic cells (PubMed:25975355).  Down-regulates IL1B production by host mast cells, and this then leads to impaired activation of IL1R1, resulting in decreased IL9 production (PubMed:26078269).  Inhibits host inflammatory reactions and recruitment of host neutrophils (PubMed:16772304).  Inhibits papain and cathepsin-L (CTSL) (in vitro) (PubMed:16772304, PubMed:17698852, PubMed:20545851).  Inhibits cathepsin-S (CTSS) (in vitro) (PubMed:17698852, PubMed:20545851).  Inhibits CTSV and CTSC, but to a lesser degree (in vitro) (PubMed:16772304, PubMed:17698852).
What are the official names of this protein?
Salivary cystatin-L, Sialostatin-L, SialoL.
What is the protein family that this protein belongs to?
Belongs to the cystatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: TUSB_ECOK1
Sequence: MLHTLHRSPWLTDFAALLRLLSEGDELLLLQDGVTAAVDGNRYLESLRNAPIKVYALNEDLIARGLTGRISNDIIPIDYTDFVRLTVKHSSQMAW
What is the function of this protein?
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
What are the official names of this protein?
Protein TusB, tRNA 2-thiouridine synthesizing protein B.
What is the protein family that this protein belongs to?
Belongs to the DsrH/TusB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINC_BACCN
Sequence: MDEKKQQNITIKGTKDGLTLHLDDCCSFTELLQELDEKLSTHYYDGDGRSLIEVHVKVGNRYLTEVQQEEIRTLIRNKKNLVVDSIESDVITKAEAIAWKEETEIVPISKIVRSGQVLHVKGNLLLIGDVNPGGMVIAGGNIFVVGSLRGIAHAGYYGDKDAVIAASVMNPMQLRISDVTTRAPEEKEDGAETAECAYINEDNHIVVDRLQLLTHLRPNLTKLERGIV
What is the function of this protein?
Cell division inhibitor that blocks the formation of polar Z ring septums.  Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.  Prevents FtsZ polymerization.
What are the official names of this protein?
Probable septum site-determining protein MinC.
What is the protein family that this protein belongs to?
Belongs to the MinC family.
Protein: DNAK_COREF
Sequence: MGRAVGIDLGTTNSVVSVLEGGEPVVIANSEGSRTTPSVVAFAKNGEVLVGQSAKNQAVTNVDRTIRSVKRHIGTDWSVAIDDKNYTAQEISARILMKLKRDAEAYLGEEVTDAVITVPAYFEDSQRQATKEAGQIAGLNVLRIVNEPTAAALAYGLEKGEQEQTILVFDLGGGTFDVSLLEIGDGVVEVRATSGDNELGGDDWDQRIVDWLVEKFQSSHGIDLTKDKMALQRLREAAEKAKIELSASQNANINLPYITVDADKNPLFLDENLSRAEFQRITQDLLDRTKTPFNQVIKDAGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGREPNKGVNPDEVVAVGAALQAGVLRGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKRSETFTTAEDNQPSVQIQVFQGEREIASANKLLGSFELGGIAPAPRGVPQIEVTFDIDANGIVHVTAKDKGTGKENTITIQDGSGLSQEEIDRMIKDAEAHAEEDKKRREEQEIRNNAESLVYQTHKFVEENDGKISEELKGKVEEAAKGVEETLKGEDIDAIKTAVDKLNTESQEMGRAIYEAEAAAGATQADAGAEGAADDNVVDAEVVDEDVSEEKKDGDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: RL10E_SULTO
Sequence: MPLRPGRCYRHFSGPAYTRKEYIPGVPMPKITKFTMGNVNGNYDYELRLVALEKGQIRHNALEAARVLALKQLTNKTGSDQNFALIVLKYPHHVIRENKMMAFAGADRLQDGMRLSFGKPIGTAARIERLGDIIMIAKVKKEHLEIAKKAFEAAASKIPLKTKIDIVPIPKEAVVQ
What are the official names of this protein?
50S ribosomal protein L10e.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: SYH_LACP7
Sequence: MITQRPKGTLDWYGDNMYKRTLIEELARKLCKAYNIKEIITPVFEHTILFQRGVGETTDVVQKEMYTFLDKKDRSITLKPEGTAGAIRAYLENNLYAESGPTKLFYVTPAFRYEQPQSGRLRQHHQFGVEFVGSKSPLAEVELITLITTFLKEIGLKKAKLHINSIGCKNCRATYNEALLTYLRKHEDHLCSTCKERMQKNPLRVIDCKESACKEIVKDAPRTIEYLDEECKNHFEELQSLLHTLNIPFEIDTGIVRGLDYYTKTVFEFVNEDGFTLCGGGRYDGLVHEIDEKQDIPSVGFGMGIERILYFLEKEEVSLPPQPAIELYVGILGAEAKASAYQLVTKLRGEGIITETDYMDRSVKAQMKYANKIGAKNTVILGADELAKGLANVKNMETGEQTELPLEDIADFILKNA
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2347_LARHH
Sequence: MAGHSKWANIQHRKGRQDAKRGKIFTRLIKEITVAAKMGGADLGSNPRLRLAVDKAKAESMPKDNIENAIKRGAGLLDGVDYIECRYEGYGIGGAAVMVDCLTDNKTRTVADVRHAFSKFGGNMGTDGCVAFQFTHCGYLVFAPGTDEDALMEAALESGADDVVSNDDGSIEVITDPNSFSDIKDALEAKGFKAEMGEVTMRAQNETELSGDDAVRMQKLLDALEDLDDVQEVYTSAVLDA
What are the official names of this protein?
Probable transcriptional regulatory protein LHK_02347.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS23B_SCHPO
Sequence: MGKPAGLNAARKLRNHRREERWADAHYKKRLLGTAYKSSPFGGSSHAKGIVVEKIGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPHDGCLNFVDENDEVLLSGFGRKGKAKGDIPGVRFKVVKVAGVGLSALFHEKKEKPRA
What are the official names of this protein?
40S ribosomal protein S23-B.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: IRAM_ECOL6
Sequence: MKWIVIDTVIQPSCGISFSVIWSKIKLIIWYQSDAFLPPESIFTLTHTGIMLNNKVLPVTIYNVVPFNKTFWNLIKNSQECPTNTDNVLNECFNNRCTLQICPYGLKQQSP
What is the function of this protein?
Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
What are the official names of this protein?
Anti-adapter protein IraM.
What is the protein family that this protein belongs to?
Belongs to the IraM/RssC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HYPB_HYPLI
Sequence: MLKFVILVCSVACVFGAVVPGGMLPQLDGRIVGGFEADIEDFPWQVSIQRGGYHFCGGSIYSPEIIVTAAHCLEKIDASQLRVRVGGSYWDEEGSLLTVSNFKIHEKYDAMIMWYDVALLKLSSKLTYGATVKNIELAKETPPDNADAVVSGWGTIYENYPYMPVQLRSVDVKIVSREVCRSDEYGYGNAIGPTMICAYAVGKDACQGDSGGPLVVGEALVGVVSWGEGCAYPGFPGVYTDVSVVRSWITENAKSF
What is the function of this protein?
Protease that shows preferential cleavage after Arg and Lys residues.
What are the official names of this protein?
Hypodermin-B, HB.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TRPC_BACHK
Sequence: MGTILDKIVDQKKKEVAALYETYTPVKEKRKTRSLVKALEQFTVIAEVKRASPSKGDINLHVDVRKQVKTYEECGAGAVSVLTDGQFFKGSFYDLQTAREESSIPLLCKDFIIDKIQIDRAYEAGADIILLIVAALTKEKLKELYSYVLEKGLEAIVEVHDEQELEIAIQLNPHVIGINNRNLKTFEVDLSQTEKLGKRLNEEKLLWISESGIHSKEDIIRVKRAGAKGVLVGEALMTSSSIHTFFEDCKVNI
What are the official names of this protein?
Indole-3-glycerol phosphate synthase, IGPS.
What is the protein family that this protein belongs to?
Belongs to the TrpC family.
Protein: CYC_HIPAM
Sequence: MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQSPGFSYTDANKNKGITWGEETLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKQATNE
What is the function of this protein?
Plays a role in apoptosis.  Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol.  Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: CITC_HAEIN
Sequence: MQFERISTEQKKLSLIQTFLHQNALKLDEQIEYFVVGYNDNEQIVVCGGLAGNIIKCVAIDESLRGSGVALQLITELVDLAYTLKRPHLFIYTKPEYATLFKSCGFYIISDANPYVVLLENSATRLQKQCSLWEKMRVDGNRIGSIVMNANPFTLGHRYLIEQALQQCDHLHLFIVGEDASQFSYTERFEMIQQGIFDLSNITLHSGSDYIISRATFPNYFLKDQLITDESYFEIDLKLFRLHIAQALGITHRFVGTELNCPVTAEYNRQMHYWLMDAEMNAPKINVIEIPRKTASNHIISASTVRKHLAEKNWAQLAEFVPMTTLNYLQKCGRF
What is the function of this protein?
Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
What are the official names of this protein?
[Citrate [pro-3S]-lyase] ligase, Acetate:SH-citrate lyase ligase, Citrate lyase synthetase.
Protein: Y604_GEOTN
Sequence: MTHAHITSWFIMIILFLIAVSMQRSGAAKANIIKMVLRLFYIITIITGLLLLHSIASISGLYWLKALAGLWVIGAMEMVLVAGKKGKSMAAGWTQWVIALVVTLFLGLLLPLGFDLF
What are the official names of this protein?
UPF0344 protein GTNG_0604.
What is the protein family that this protein belongs to?
Belongs to the UPF0344 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MFNA_META3
Sequence: MDERAVLEELKKYRKMDLKYEDGAILGSMCTKPHPITKKISDMFFETNLGDPGLFRGTKKLEDEVINNIGKFLNNPNPFGYIISGGTEANITAMRAINNIAKAKRKNHKTTVIMPETAHFSFEKAREMMDLNLITPPLTKYYTMDLKYINDFIEDRNNKNDISVDGIVGIAGCTELGAIDNIKELSKIAEQNNIFLHVDAAFGGFVIPFLDDKYKLDNYCYEFDFSLNGVKSMTVDPHKMGLAPIPAGGILFRDKSFKKYLDVEAPYLTDIHQATIIGTRSGVGVASTWGVMKLFGEEGYKNLASECMDKTHYLVKEAKKLGFKPVIDPVLNIVALEDDNPEETSLKLRKMGWFISICKCVKALRIIVMPHVEKEHIDKFLGALTEVKKN
What is the function of this protein?
Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis.  Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
What are the official names of this protein?
Probable L-tyrosine/L-aspartate decarboxylase, TDC/ADC.
What is the protein family that this protein belongs to?
Belongs to the group II decarboxylase family. MfnA subfamily.
Protein: NRDR_CAUVC
Sequence: MRCPFCGHAESQVKDSRPSEDGAAIRRRRMCPECGGRFTTFERVQLRELIIVKRSGRRSPFDRDKLVRSVGLATQKRPVDPERVERMVNGIVRQLESMGETELPSSTVGEMVMKALKSLDDVAYVRYASVYRDFKETSDFAKFLTEEGLSDGGEEEL
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: YD509_YEAST
Sequence: MMFTFIFHIFNGFFHCFFKIFYFIFRFYRANLFFLWLYFLHLVMGNIVKVVTIHIHIRASLIIPPMASITKRHNVQYLILYKLLEKAIVFFSYTKKKKHKAPITLNFEEARKEYV
What are the official names of this protein?
Putative uncharacterized protein YDR509W.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: FOLD_PROM4
Sequence: MAHKLDGKQLAGEIEQRLSHEITLCLKKGVRPPGLAVIRVGDDPASQVYVSNKEKACRRAGIKSFGCHLDANSSFREIEEQIIKLNSNQEVDGILLQLPLPIGLDAGRLLKVIDPRKDADGLHTLNLGRLLKDEIGPRSCTPAGVMALLAANQIEIKGKNTVVIGRSILVGKPMALMLQAANATVTLVHSHTRDLIGFTKQAEILVVAAGKPQLIGLEHVKEKSVVVDVGIHRVFKDQNLGDAGGYKLCGDVRREEVDDFVSAITPVPGGVGPMTVAMLLVNTVNSWQQHCDLSLSLDDLLP
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: RL4_ECO7I
Sequence: MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: LSPA_RHIWR
Sequence: MADARSLHRPLGFGVAAIVLLLDQISKWAIMGPVALRERGLIEITGFFDLRWVENYGVSMGFLIAGSDRERWLLVAGTALIAAGIVAWIWREKAKGDVVALGLVLGGAIGNIADRTRLGYVADFLDPHIGDWHPFLVFNVADAAITIGVLILVLRALLVREPKVPAENVDAV
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: OMD_RAT
Sequence: MGCLRPIYVLFFCFVVRVYGQYEAYQWDEDYEQEPSEDYEPEFQFHQNIEYGAPFYQNILGCAKECFCPTNFPTSMYCDNRKLKTIPDIPMHIQQLNLQFNDIEAVTADSFINATHLKEINLSHNKIKSQKIDYGVFAKLSNLQQLHLDHNNLEEFPFPLPKSLERLLLGYNEISTLPTHAMDGLVNVTMLDLCYNHLSDSTLKGKILSKLEKLMQLNLCNNRLESMPPGLPLSLMYLSLENNSISSIPEDYFQKLPKLHALRISHNKLEDIPYDIFNLSNLIELNVGHNKLKQAFYIPRNLEHLYLQNNEIQSINVTMMCPSLDPLHHHHLTYLRVDQNKLKEPISSYIFFCFPRIHSIYYGEQRSTNGETIQLKTQVFRRYQDEEEEEEDDSQDHTLEGQEETEEHFNSHYYEMQAWQNTI
What is the function of this protein?
May be implicated in biomineralization processes.  Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin.
What are the official names of this protein?
Osteomodulin, Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, Osteoadherin, OSAD.
What is the protein family that this protein belongs to?
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: RUVB_SHEB8
Sequence: MIEADRLIQPQIQAQDESIDRAMRPKMLDEYTGQDDTRAQLKVFIQAAKNRNEALDHMLIYGPPGLGKTTLAMIVANEMGVNIKSTSGPVLEKAGDLAALLTNLESGDVLFIDEIHRLSPVVEEILYPAMEDYQLDIMIGEGPAARSIKLDLPPFTLVGATTRAGALTSPLRARFGIPLRLEFYNIKDLSTIVTRSAQVMELDIDAEGAFEIARRSRGTPRIANRLLRRVRDYAQVKHDGAVTKFVAEHALDLLDVDSEGFDYMDRKLLLAIIDKFMGGPVGLDNLAAAIGEERETIEDVLEPFLIQQGFIQRTPRGRIATVRAYQHFELIKPE
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: RIBA_AERHH
Sequence: MSSVTLVAKSKLPTPWGTFTLVGFQETGTGKDHAALVMGDITGDEPVLGRIHSECLTGDALFSLRCDCGFQLQAALENIAKAGRGVLLYVRQEGRGIGLLNKIRAYHLQDQGADTVEANVALGFAADMRDYTICADMLKQLEVKSLKLMTNNPRKMKAMESFGIPVAERVPLQEGRNPHNEFYLSTKANKLDHMFKK
What is the function of this protein?
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
What are the official names of this protein?
GTP cyclohydrolase-2, GTP cyclohydrolase II.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase II family.
Protein: MNMG_CHESB
Sequence: MIHKFDVVVVGGGHAGCEAAAAAARAGARTALVTMRRDTIGVMSCNPAIGGIGKGQLVREVDALDGLMGRVADAAGIQFRLLNRRKGPAVRGPRTQADRKLYRQAMQAVISEQENLQVIEAEVHTLGMEHGRITHVGLSGDSQINCAAVVLTTGTFLRGLIHIGQKKIPAGRVNEPAAKGLSASMEAAGFKLGRLKTGTPPRLDGRTIEWNMLGFQKADEDPVPFSLLSEKIQNPQITCGITRTTTDTHRIIQENLDKSAMYSGQIEGIGPRYCPSIEDKIVKFGERDGHQIFLEPEGLDDHTVYPNGLSTSLPEEVQHAFLKTIPGLANAHVLQPGYAIEYDHVDPRELEPSLETRRVRGLFLAGQINGTTGYEEAAAQGVIAGINAASVASGSTTVVPSRTDAYIGVMIDDLVTRGVTEPYRMFTSRAEFRLSLRADNADERLTPRAIEWGVASKVRRDRFYKAEQELSDARELTKARGLTPNEAARHGIAVNQDGVRRSAYDLLSFADINIERLKAIWPELGSIAPKTCERLETEARYAVYLDRQVADAERVRREEGRSIPDGIDFDSVPGLSNELKYKLRQRRPRTLAEAQRIDGMTPAALALILVAIRQGEKIRGAA
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTC5_YEAS2
Sequence: MGQSSSISSSNEEGSSHSKKFTNSKDILAYFNNKAQQQVTIPELVSFKGNLQIEDLNTPISHKALCNSLYFPQNHAMIVGIVTNMLRVLSNFPLMKSSYEPITGYGLLKCILLLNRARCAKFLKTKSYDQLKLLFISLSLQKTDKEELSEESENDGNKELTIKQIITGFDDVDTEMLCIPADFMLQFLTWLLILTVDCPTTNSKLDNTETHDQWGNFKVSALNLLRTMNPDVVGDIESHSITFQQFSTAIRTVMPNLLKPLENLMEHFFYLQHDLVDHDTNLSSIQDSKVMTPALLAQLSTGLPKELFIHKLQSLYIGRKSGFSMRSLQAKVFKWMAPSILVVSGMRITNSEEYAAEKNPRYRHFLEEFPKLKESDQMMDASHLNKRKTTFAVYIDDPWKVTNKDYFGDLNTRIIEISPRQDIYKVNQKGTIYFNTIGGGIGIGDKQPLIKPASKRYIPGNVSLTFDSTLEFAVFRNTGYGGSLDPGLLSMERKEENSPYELHFLIQDVEVWGCGGEKELEEQIKQLEWEEAESKRRQQINLRSLGEDRALLEMAGLVGQHQGGGSM
What is the function of this protein?
May be involved in a process influencing telomere capping.
What are the official names of this protein?
Restriction of telomere capping protein 5.
What is the protein family that this protein belongs to?
Belongs to the RTC5 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDUF4_RAT
Sequence: MGARMTRAFRNFNVEKRAEQEISKRKPSMAPKHPSTRSLLQEHLSQYPEIEEEVSRKDNKLLSLLRDVYVNSKDPVPSLPVKAIEPQQQPKEFRLPIGDQFDKNIKDIPKGKITVVEALTLLNNHKLSPETWTAEKIAQEYHLELEDVNSLLKYFVTFEVKIVPPEDRKAIQSK
What is the function of this protein?
May be involved in cell proliferation and survival of hormone-dependent tumor cells.  Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity).
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4, Hormone-regulated proliferation-associated protein of 20 kDa homolog, Protein HRPAP20.
What is the protein family that this protein belongs to?
Belongs to the NDUFAF4 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Lipid-anchor.
Protein: PHF2_HUMAN
Sequence: MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATPPQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYNPSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLTPNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL
What is the function of this protein?
Lysine demethylase that demethylates both histones and non-histone proteins (PubMed:20129925, PubMed:21167174, PubMed:21532585).  Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B (PubMed:21532585).  Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes (PubMed:21532585).  The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver.  PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (PubMed:21532585).  Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters (By similarity).
What are the official names of this protein?
Lysine-specific demethylase PHF2, GRC5, PHD finger protein 2.
What is the protein family that this protein belongs to?
Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Chromosome, centromere, kinetochore.
Protein: Y118_ARCFU
Sequence: MKKIELYTYDDAVKDMEEGATEAEVTARKWESILYALREIEEVALQLTPLCEKYIDFDCEGCPLTNFDLPCSEAISTYSLFCGDLKKLRMVAENMLSMILAAGRYEERRNSFFV
What are the official names of this protein?
Uncharacterized protein AF_0118.
Protein: DMR6_ARATH
Sequence: MAAKLISTGFRHTTLPENYVRPISDRPRLSEVSQLEDFPLIDLSSTDRSFLIQQIHQACARFGFFQVINHGVNKQIIDEMVSVAREFFSMSMEEKMKLYSDDPTKTTRLSTSFNVKKEEVNNWRDYLRLHCYPIHKYVNEWPSNPPSFKEIVSKYSREVREVGFKIEELISESLGLEKDYMKKVLGEQGQHMAVNYYPPCPEPELTYGLPAHTDPNALTILLQDTTVCGLQILIDGQWFAVNPHPDAFVINIGDQLQALSNGVYKSVWHRAVTNTENPRLSVASFLCPADCAVMSPAKPLWEAEDDETKPVYKDFTYAEYYKKFWSRNLDQEHCLENFLNN
What is the function of this protein?
(Microbial infection) Required for susceptibility to the oomycete Phytophthora capsici.
What are the official names of this protein?
Protein DOWNY MILDEW RESISTANCE 6, AtDMR6, 2-oxoglutarate (2OG)-Fe(II) oxygenase-like protein DMR6, Salicylate 3-hydroxylase DMR6, S3H DMR6, SA 3-hydroxylase DMR6, Salicylic acid 3-hydroxylase DMR6.
What is the protein family that this protein belongs to?
Belongs to the iron/ascorbate-dependent oxidoreductase family.
Protein: EX7S_MANSM
Sequence: MARKPKESSTVDFETTLNQLETIVTRLEAGDLPLEEALKEFENGIKLAKLGQERLQQAEQRIQILLQKSDTAELTDYQPTDE
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.