PharMolix/UniProtQA huggingface dataset:
Protein: ING2_MOUSE
Sequence: MLGQQQQQQLYSSAALLTGERSRLLSCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSESRDLCHMTNGIDDCDDQPPKEKRSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKERRAR
What is the function of this protein?
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53.  Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones.  ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).
What are the official names of this protein?
Inhibitor of growth protein 2, Inhibitor of growth 1-like protein, p33ING2.
What is the protein family that this protein belongs to?
Belongs to the ING family.
What are the subcellular locations of this protein?
Nucleus. Note=Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm (By similarity).
Protein: SYW_LACLA
Sequence: MTKPTILTGDRPTGKLHIGHYVGSLQNRVKMQNEDKYNMFVFLADQQALTDHAKEPELIRQSVGDVALDYLAAGLDPEKSTIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQKAFGESIPAGFLVYPVSQAADITAFKATHVPVGNDQKPMIEQTREIVRSFNNAYHTDVLVEPEGIYPENEAAGRLPGLDGNAKMSKSLGNGIFLADDMDTLKKKVMSMYTDPDHIKVEDPGKIEGNMVFHYLDVFGKAEDAEQISEMKAQYQAGGLGDVKTKRFLLDVLDRELSPIRERRIEFAQNMDYVYDMLKAGSLKAQAVASQTLDEVKSAMGINYFK
What is the function of this protein?
Catalyzes the attachment of tryptophan to tRNA(Trp).
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAIE_SALG2
Sequence: MSYYAFEGLIPVVHPDAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLILEAGSNLQDGCIMHGYCDTDTIVHENGHIGHGAILHGCVVGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFQGEARQLLVGSPARVLRQVTDQELHWKRLNTKEYQDLAIRCRTGLSETKPLTQVEENRPRLKGTTDVKPKSAQ
What is the function of this protein?
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
What are the official names of this protein?
Carnitine operon protein CaiE.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
Protein: HISZ_HALH5
Sequence: MSKPFMFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASSLKDRAYPLRLAYQSNVYRAQQNEGGKPAEFEQLGVELIGDGTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMDVVGNEQRADRLRRFLYEKNYVGYREHVKSLNLSTIDKSRLMNLLSLRGGRAAIEEARGLIQTEKGKTALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLGVPLCSGGRYDELLSKFHRPAQATGFGVRIDLLVEALNGEIISNGHEQTCILFSNERRFEAIELARKKRANGEAVVLQDLAGVTDVDAMSSNYQDVIYCIGTAGRGGEDA
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
Protein: AGALD_ASPOR
Sequence: MLPKIFYLSLLPAALGHPHLQPRLDNGLARTPQMGWNTYNHYSCSPNETIVRSNAQALVDLGLASLGYRYVTTDCGWTVADRLSDGSLTWNETLFPKGFPALGKYLHDLDLLFGVYQDSGIKLCGSPPDNVGSLYHEDQDARTFASWEVDSLKYDNCYSDAATGYPNVNYEPSTSPQPRFANMSRALAAQNRSMVFQVCEWGIDFPARWAPALGHSWRIGNDIIPHWRAIYRTLNQAVPQTSFAGPGQWPDLDMLFVGNDILSIPEEQTHFSLWAILKSPLTIGAALKDDNTSINDESLQILKQEEVIGYNQDSLGVSASLRRRWTEEGYEVWSGPLSGGRTVAALINWKDEARELTLDLPDIGLQFAGTVKNIWDGTTAQNVKTSYTAKVQSHGTILLELQDTTASGQYPTDTFATSTDSSTTFESIYGVTTSFRYNITVKLSEASSSGDVNIQSTASNKTITAQVSASGTEASAQIPLLAGSSNSITIVSPQSVDAITITPPNGTYFPNTAFTTTGDADTVSCGAGYCQPVGSKIGNISTNGTARAVIPATAGTKYLAIDYINNDVAFDSAWDWGSNSRNLTVSVNGNKPVRIEVPLSGQHSELFGPGKGWWDTATIGVLTEGWKDGDNDVVIGNEGGESGFTSYGPDFVGLRVL
What is the function of this protein?
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
What are the official names of this protein?
Probable alpha-galactosidase D, Melibiase D.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 27 family.
What are the subcellular locations of this protein?
Secreted.
Protein: HBSAG_HBVD7
Sequence: MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWDFNPNKDTWPDANKVGAGAFGLGFTPPHGGLLGWSPQAQGIIQTLPANPPPASTNRQTGRQPTPLSPPLRNTHPQAMQWNSTTFHQTLQDPRVRGLYFPAGGSSSGTVNPVPTTASPISSIFSRIGDPALNMENITSGLLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGTTVCLGQNSQSPTSNHSPTSCPPTCPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLPVCPLIPGSSTTSVGPCRTCTTTVQGTSMYPSCCCTKPSDGNCTCIPIPSSWAFGKFLWEWASARFSWLSLLVPFVQWFVGLSPTVWLSVIWMMWYWGPSLYRILSPFLPLLPIFFCLWVYI
What is the function of this protein?
The middle envelope protein plays an important role in the budding of the virion.  It is involved in the induction of budding in a nucleocapsid independent way.  In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
What are the official names of this protein?
Large envelope protein, L glycoprotein, L-HBsAg, LHB, Large S protein, Large surface protein, Major surface antigen.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus major surface antigen family.
What are the subcellular locations of this protein?
Virion membrane.
Protein: Y2649_STAAC
Sequence: MKKLAVILTLVGGLYFAFKKYQERVNQAPNIEY
What are the official names of this protein?
Uncharacterized protein SACOL2649.
Protein: YLYA_BACMT
Sequence: MLIRYKKAFEKIAMGLLSFMPNEKDLKKLQQTMKQYETEEDRQLFLWKEEEDIIGLIGVLVVNEYEVEIHHISVNPSHRHQGIGKSMVKALRDIYPDKELIPNENTAAFIEKCEICHGSE
What are the official names of this protein?
Uncharacterized N-acetyltransferase in lysA 3'region, ORF3.
Protein: Y454_MYCPN
Sequence: MGFFKLLFKLAFLAVLTVAIAYLFLAIFYFGTVSPSFKLAQPMDVFNRFFSKEALDTVTTSGVGATVTAPKAAAASQSHALILAAEQVANNANKLDPRFPIDGSLFSQIPGYVDFLKKPNIPAFLEKVGPYLTKYIIPLGMALVSGLIGALIINFILSKITRAIIKKRRKAKRAQQSRVDDYYYDEAPRRRRR
What are the official names of this protein?
Uncharacterized protein MG319 homolog.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MFTF_MYCTU
Sequence: MTATRLPDGFAVQVDRRVRVLGDGSALLGGSPTRLLRLAPAARGLLCDGRLKVRDEVSAELARILLDATVAHPRPPSGPSHRDVTVVIPVRNNASGLRRLVTSLRGLRVIVVDDGSACPVESDDFVGAHCDIEVLHHPHSKGPAAARNTGLAACTTDFVAFLDSDVTPRRGWLESLLGHFCDPTVALVAPRIVSLVEGENPVARYEALHSSLDLGQREAPVLPHSTVSYVPSAAIVCRSSAIRDVGGFDETMHSGEDVDLCWRLIEAGARLRYEPIALVAHDHRTQLRDWIARKAFYGGSAAPLAVRHPDKTAPLVISGGALMAWILMSIGTGLGRLASLVIAVLTGRRIARAMRCAETSFLDVLAVATRGLWAAALQLASAICRHYWPLALLAAILSRRCRRVVLIAAVVDGVVDWLRRREGADDDAEPIGPLTYLVLKRVDDLAYGAGLWYGVVRERNIGALKPQIRT
What is the function of this protein?
Involved in the biosynthesis of the enzyme cofactor mycofactocin (MFT).  Acts as a glycosyltransferase that catalyzes the oligoglycosylation of pre-mycofactocin (PMFT), adding up to nine beta-1,4-linked glucose residues.
What are the official names of this protein?
Pre-mycofactocin glycosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HIS2_MYCTO
Sequence: MQQSLAVKTFEDLFAELGDRARTRPADSTTVAALDGGVHALGKKLLEEAGEVWLAAEHESNDALAEEISQLLYWTQVLMISRGLSLDDVYRKL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMB_ASPFC
Sequence: MTPPPPKRQKRDEYRKATAEATSQSGASDVAEIKLPKKKYYRQRAHANPFSDHHLKYPLSPAHMDWSSHYPAFVDPDPSHINLAGARRLLKDVEVVDIGCGFGGLLIGLAPLLPESLIVGMEIRVSVLEYVTTRIQALRAQQQKLRAATATATAASETPSQQQAQIDGKQANANAAADAASPAPSTDTEHMPTTLVPGSYENISAIRSNTMKFFPNFFARHQLSKIFICFPDPHFKARKHKARIISETLNAEYAYALRPGGLLYTITDVEEYHHWILRHFGVELGAEEESEEKSTSPNANANAGVRELFERVSEEELEKDECVRVMKEATEEGKKVARNKGNKYVAVFRRKTDPEWPA
What is the function of this protein?
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
What are the official names of this protein?
tRNA (guanine-N(7)-)-methyltransferase, Transfer RNA methyltransferase 8, tRNA (guanine(46)-N(7))-methyltransferase, tRNA(m7G46)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y754_BURA4
Sequence: MSKPSDRINLTNQFLIAMPNMADPTFSGTVVYLCDHSERGALGLVINRPTDIDLESLFNRIDLKLDIEPLLHIPVYFGGPVQTERGFVLHEPVEGANYNSSMSVEGGLEMTTSKDVLEAVATGTGPKRFLLTLGHAGWGAGQLEEEISRNGWLTVAADPRIVFDTPAEERFEAALGLLGVSSSMLSGEAGHA
What are the official names of this protein?
UPF0301 protein BamMC406_0754.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: XERS_STRA5
Sequence: MKRELLLEKIDELKEIMPWYVLEYYQSKLSVPYSFTTLYEYLKEYRRFLEWLLDSGVANCHHIAEIELSVLENLTKKDMEAFILYLRERPLLNANTRQNGVSQTTINRTLSALSSLFKYLTEEVENADGEPYFYRNVMKKVSTKKKKETLASRAENIKQKLFLGNETIEFLEYIDCEYQNKLSKRALAFFNKNKERDLAIIALLLASGVRLSEAVNLDLKDINLNVMVIDVTRKGGKRDSVNVASFAKPYLANYLDIRKNRYKAENQDIALFLSEYRGVPNRIDASSVEKMVAKYSQDFKVRVTPHKLRHTLATRLYDATKSQVLVSHQLGHASTQVTDLYTHIVNDEQKNALDKL
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.
What are the official names of this protein?
Tyrosine recombinase XerS.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerS subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 030L_IIV3
Sequence: MHPTLKSNAGEWSQPIVNLFYSNFSGNCKALLQYIDNAGITDHIPIKFINVDNPTMRSVVSAKISHVPALVVLQDDQMSLYVAESVWEWFDNYRTPPPLADGATVDSQASENGEKEAQPTPPKEGLLTVLELAKQMRKEREQQT
What are the official names of this protein?
uncharacterized protein 030L.
Protein: PSA3_HUMAN
Sequence: MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM
What is the function of this protein?
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.  This complex plays numerous essential roles within the cell by associating with different regulatory particles.  Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins.  The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required.  Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation.  This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).  Binds to the C-terminus of CDKN1A and thereby mediates its degradation.  Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.
What are the official names of this protein?
Proteasome subunit alpha type-3, Macropain subunit C8, Multicatalytic endopeptidase complex subunit C8, Proteasome component C8.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1A family.
Protein: TPH1_CHICK
Sequence: MIEDNKENKDHAPERGRTAIIFSLKNEVGGLVKALKLFQEKHVNLVHIESRKSKRRNSEFEIFVDCDSNREQLNEIFQLLKSHVSIVSMNPTEHFNVQEDGDMENIPWYPKKISDLDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPEIEFTEEEIKTWGTVYRELNKLYPTHACREYLKNLPLLTKYCGYREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDEAVQKLATCYFFTVEFGLCKQEGQLRVYGAGLLSSISELKHSLSGSAKVKPFDPKVTCKQECLITTFQEVYFVSESFEEAKEKMREFAKTIKRPFGVKYNPYTQSVQILKDTKSIASVVNELRHELDIVSDALSKMGKQLEV
What is the function of this protein?
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
What are the official names of this protein?
Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Protein: YBEY_BORHD
Sequence: MIKEELNLWAEGVEFKHWDAYYNFILSVLNFLCIEEYELSVVLCNNEYIQKLNSAFRQKSEPTDVLSFNYLEENGQINHKIQGDLIISLEYLEFSSLEFNVEMYDELQRNTIHGILHLIGYTHETNDFQNEEMLVIQEKVLRETRRVF
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CFA53_MOUSE
Sequence: MYSQQFGTVPREFKGPTPKAVIIRAKPPKAQRAEQHLKRIQRSYHKYHTTLASIKSNEENRLKCDWIQRNNHKTFDSLVQARVQDAMQGFVINTEERRNKLRELLASEENEYFSEMQLKGETIEEKKDKMRERTKLLREKKEKERQEFVAEKLDQQFRERCEELRTKLASIHEKKVVEERNAQIEFNKELKRQKLVEEHLFARLWEEDRLAKERREAQEEKRQRELVQNTRLGLDAQVTSIQAQRQGARRMKEEEARILEQNKAQIKREDEQEKLQKQKRRQETRSSLKKAVQDKIESMQREYREDLDLNMKLVGRALQDLQDEADKKKQKREEMGREQKIYNDYLMQRREEEKAQEKELNRLLEDIKAKKLAEKDRELALQRAARKQLMNEVMNTRKLQVQERLQRKLREQEELALHEQRISESLKVLHQEDMEDFARRCALAEEYRNQLQMQIAHQQQAREAEKEEERQEFEAGLAANKACLDKIQRILSENQALSQNVHPMRRGYPDKPPL
What is the function of this protein?
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (By similarity).  May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis (By similarity).
What are the official names of this protein?
Cilia- and flagella-associated protein 53, Coiled-coil domain-containing protein 11.
What is the protein family that this protein belongs to?
Belongs to the CFAP53 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, cilium axoneme.
Protein: SRS1B_DANRE
Sequence: MSGGVIRGPAGNNDCRIYVGNLPPDIRTKDVEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGGGRGGGGGGGVGAPRGRYGPPSRRSEYRVIVSGLPPSGSWQDLKDHMREAGDVCYADVFRDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSNSRSRSYSPRRSRGSPRYSPRHSRSRSRT
What is the function of this protein?
May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.
What are the official names of this protein?
Serine/arginine-rich splicing factor 1B, Splicing factor, arginine/serine-rich 1, Splicing factor, arginine/serine-rich 1B.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
Protein: VPS10_SCHJY
Sequence: MLHHCVLHIICALFFFLPLGGADSNYAISKLGTASKSQKSLIVNFSKSRNILLLDATGTLLLSQDDGTSWQDAVSNSDPAVVEQLYQHPFEDDIVYAITKESDILVSEDAGLTWFTVTMPPKTVIEAQPFEFNARQSQSVILNAARCESGSIWTGVTCYPFTYYTYDNFRNLDSVHDSIVSCTFAVGTVEFAGQDEDQMLCLIRENDVDLQAPFNQQLISVSKGFESIDYVVFDPYYGSLGTESVVAVGQYLVAAVVDVNSKKLKLHYSTDGQIWVPITFINAPSIGSLTVTRSTSLTLGVDVESTNLKNPVGEFYTISPSDAYAVRRLNDTNRDTRGYVDVIELDYLNNTILANTVANTEDLYKRASRQKELVTKISHDGGFSWTQLERPVDLECEGDDAEDCHLHLHLGITETKFGSLSPDRLPGVIMALGSVGTHLQPLSDSDLFISEDAGRSWYLSLQGPHYYSSSAYGSVFVAVKANENSKLIYYSLDFGREWESLEVEASFRALEIIPPKSLDSLTFLIRAKVKKEESFIAIDFSSILSRECTFDEKKVANGDFELWYPFVMDDTPQCLMGRIEYYLRKKRAVSCVVRNEVPVHSFVEQICTCESKDYECSTYFEPSDHFTCEVNPESLDPLCRVDPDATLQLKPYRILLGNSCVPKKKEEKEKSISMKCPKLDHRKDIHMYHHKIQDTISNIVYMEGTGEPDSTTELLLTSSQKVLFSYDFGEEWLEFDEKKNPSFYGIYPHAFLKDTAFLLTKDRKIYFTNNKGRSFYRLDAPSPPNVVGYPVFNFHSLHPNWVMYMGSENCDDSFYEDCRSVVYLSFDSGASWQKLPDELEYCSWVLGERLLVEDKLLFCNRRRAAADSIGYDLVASTDFFETEASSIRENVLGFLLADEYVVIAALTDDETSLSMHVSVNGRNFSPCIFPQNIQVHSQQAYTILSSKTRALFIHVTLSSRKGAEWGSVLKSNSNGTYFVNVLDKVNRNELGYVDFEKVEGLESIALANVVLNSDEAFNGEEKRLGTLITFNDGIDWERLYLIDAKKHYPHCDSKCSLHFHGFTERSVFSDPTSSSAATGIIFGIGSYSYYLEPYETSQTFISRDGGVHWELIFDSPHQWAFVDSGSLLVAVPSTNKTNILYYSEDEGRSWIAYQFAEDTYLIEDLSTAPSGNSQRILVLAKGKKSSETISFTVDFSHLRSRVCVFDFNDQRDFASWTPAGRDGKPMCLFGHKTAFYRRKPGRDCFIGNTPYVSDTIISNCQCTRMDYECNYNYERIAGGTCRLVSGAEPPLQQEEQCAAEGAIEWMEPTAYKRIPLTTCEGGLVLDESTTHPCPGKEDDYHKIHPGTPVWLIIMLVLLSVFLSTIVGAWVYTKAQSYLVGAIRLGEDPADETVFAKLMTRIESVVTAVPIFFSAAYHLVRSVFVRQDRSMSLDDYDNFEGMEDAAFLEVDDIETSE
What is the function of this protein?
Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.  Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
What are the official names of this protein?
Vacuolar protein sorting/targeting protein 10, Carboxypeptidase Y receptor, CPY receptor, Sortilin vps10, Vacuolar carboxypeptidase sorting receptor vps10.
What is the protein family that this protein belongs to?
Belongs to the VPS10-related sortilin family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Prevacuolar compartment membrane; Single-pass type I membrane protein. Note=Cycles between the Golgi apparatus and the prevacuolar compartment.
Protein: SC5AB_MOUSE
Sequence: MESATISPQPPQSDSLEAFPQKSMEPADIAVLVLYFLFVLAVGLWSTVRTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAAVGISVAAYELNGLFSVLMLAWVFLPIYIAGQVTTMPEYLRRRFGGNRISITLAVLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITALYTVAGGLAAVIYTDALQTVIMLIGAFILMGYSFAAVGGMEGLKDQYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGILFGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLMAAYLKVLPLFLMVFPGMVSRVLFPDQVACAHPDICQRVCSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHIRPRASERELMIVGRIFVFALVLVSILWIPIVQASQGGQLFIYIQSISSYLQPPVAMVFIMGCFWKRTNEKGAFSGLILGLLLGLVRLILDFVYAQPRCDQPDDRPAVVKDVHYLYFSMILSFTTLITVVTVSWFTETPSKEMVSRLTWFTRHEPVAQKDSAPPETPLSLTLSQNGTTEAPGTSIQLETVQESTTKACGDGVSPRHSKVVRAILWLCGMEKNKEEPPSKAEPVIVSLEENPLVKTLLDVNCIVCISCAIFLWGYFA
What is the function of this protein?
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1.  Exclusively responsible for apical MI transport and absorption in intestine.  Can also transport D-chiro-inositol (DCI) but not L-fucose (By similarity).  Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity).  May induce apoptosis through the TNF-alpha, PDCD1 pathway (By similarity).  May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity).
What are the official names of this protein?
Sodium/myo-inositol cotransporter 2, Na(+)/myo-inositol cotransporter 2, Sodium-dependent glucose cotransporter, Sodium/glucose cotransporter KST1, Sodium/myo-inositol transporter 2, SMIT2, Solute carrier family 5 member 11.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein.
Protein: NSRR_SHIF8
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKPASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: NUOK_PARL1
Sequence: MAIGLEHYLTVAAILFTLGIFGIFLNRKNVIVILMSIELMLLAVNINLVAFSTHLGDLAGQVFALFVLTVAAAEAAIGLAILVVFFRNRGSIAVEDINMMKG
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECF_ACTP7
Sequence: MPLSRLIINNFRNLQSLDLELSPNFNFIVGHNGSGKTSLLEAIFYLGHGRSFKSHISNRIIHYQAEDFVLHARIDEGQHQWSVGIQKKRSGDTLLKINGEDGNKISDLAHLLPMQVITPEGLTLLNGGPTFRRAFLDWGLFHQYTEFYSCWANLKRLLKQRNAALHQVRSYAELKPWDIELAKLAEIVSQMRASYAEALRPEIEKTCQFFLPELEIGVSFHQGWEKGTDYAEILAQGFERDKAMGYTMIGPQKADFRFRANGLPVEDVLSRGQLKLLMCVLRLAQGEYLVAQKERQCLFLIDDFASELDPIKRELLAHRLRESGSQVFVTAITKDQLNQMQWQESEQDSLFQVQQGMLTK
What is the function of this protein?
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility.  RecF binds preferentially to single-stranded, linear DNA.  It also seems to bind ATP.
What are the official names of this protein?
DNA replication and repair protein RecF.
What is the protein family that this protein belongs to?
Belongs to the RecF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_SHEDO
Sequence: MKAAKNNVYTVSRLNGEVRQILEGQIGKIWLNGEISNFSSPSSGHWYLTLKDTHSQIRCAMFKGRNQSVNFRPVNGQQVLVKGAISVYEPRGDYQLLLESMLPAGDGLLAQEYEALKMKLAAEGLFASETKRALPSNIQRIGIITSATGAALRDVLHVLQRRDASIEVVVYPTQVQGTSASDNICRAIELANKRLEVDVLLLTRGGGSLEDLWCFNNEMLAHSIYNSALPVVSAVGHEVDTTISDYVADVRAPTPSAGAELLSQDKGNKAQKLALMLSRLAQGMRHYQLSQDKHFVNLQHRLNQQDPKRRLQQLEQQFDEFQLRLDNAFKHRLSRLTLRHERLSAQLQRQSPEHKLRLAHQALTHVSGRFDDAIKDTLGSAEQRLKQAVHQLEAMSPLATLSRGYSISSNANGKVITDASKVKVGDSLHTRLAKGQLVSTVIDVEM
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIPA_SORC5
Sequence: MAQFSPKPEWLKVRAPGGDTYHHLKETFRKLDLHTVCEEARCPNVGECWREGTATVMLLGDVCTRGCRFCAVTTGDPRGAVDVREPEHVARAIARLSLQYVVMTMVNRDDLLDGGAEHVARTVSRLHALRPDLLIETLVGDFQGHMSAVDMVVDAGPDVFAHNVEVVRRITRVIRDVRSSYDQSLAVLRRAKERQRRLAADAAEAGAPAPRRLTKSSIMVGIGETDDEVLEALRDLREAGVDIVTIGQYLRPSSKHAPVQRFVEPETFAAFERAALEMGFLYAASAPLVRSSYKAAEVFVRSLMDRGGAALPASPGAAAVEALLEERLAVARREAARLTAELDPDEPRPPVAPAPASASPARLVPAASLIRR
What is the function of this protein?
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
What are the official names of this protein?
Lipoyl synthase, Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Lipoyl synthase family.
What are the subcellular locations of this protein?
Cytoplasm.