PharMolix/UniProtQA huggingface dataset:
Protein: F16PA_VIBVY
Sequence: MSGMRTLGEFIVEKQADFPHASGDLSSLLSSIRLAAKIVNREINKAGLVDITGAAGVENIQGEVQQKLDVYANEKFKSALEARDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVSPIGTPPTQEDFLQPGHKQVAAGYIIYGSSTMLVYTTGNGVNGFTYDPSLGTFCLSHENMMIPQNGNIYSINEGNYIRFPMGVKKYIKYCQENVPEDGRPYTSRYIGSLVADFHRNLLKGGIYLYPSTQSHPQGKLRLLYECNPMAFLIEQAGGLASDGVNRILDLKPTELHQRVPFFVGSTNMVKKVEEFLEVYRDEA
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 1, FBPase class 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPK5_PANVI
Sequence: GGETGSDAKAMWFGPRL
What is the function of this protein?
Myoactive.
What are the official names of this protein?
Pyrokinin-5, Panvi-PK-5, FXPRL-amide, PanVi-Capa-PK.
What is the protein family that this protein belongs to?
Belongs to the pyrokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SPP2_KLULA
Sequence: MNGISISLKSKNKVKKKSGTKKKKKPTVFGIADNDEKATEFKITSVEERKETIKKPLCITPTEPLRSSLNARPESGSLKSEDEQAVVFPEESESKFDFKGPSALRNNIPEKTNEEEYEEVPVEGFGTALLRGMGWDPSAENDSSSEKSTLLHEKPHPELVGIGAKLTTASNSLRTAFMPLIRRKKTANE
What is the function of this protein?
Involved in spliceosome maturation and the first step of pre-mRNA splicing.
What are the official names of this protein?
Pre-mRNA-splicing factor SPP2.
What is the protein family that this protein belongs to?
Belongs to the SPP2 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RL31_SHEAM
Sequence: MKPGIHPEYAQITATCTCGNVIKINSTVGKDLHLDVCGACHPFYTGTQKVVDTGGRIDKFNKRFGMLGKK
What is the function of this protein?
Binds the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L31.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Protein: RBL_GALCO
Sequence: MSPQTETKAGVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEERGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGEEDQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPVAYVKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLSHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDYIEKDRSRGIYFTQDWVSLPGVLPVASRGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLASEGGEIIREACKWSP
What is the function of this protein?
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process.  Both reactions occur simultaneously and in competition at the same active site.
What are the official names of this protein?
Ribulose bisphosphate carboxylase large chain, RuBisCO large subunit.
What is the protein family that this protein belongs to?
Belongs to the RuBisCO large chain family. Type I subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y207_STRPS
Sequence: MSHDHNHDHEERELITLVDEQGNETLFEILLTIDGKEEFGKNYVLLVPVNAEEDEDGQVEIQAYSFIENEDGTEGELQPIPEDSEDEWNMIEEVFNSFMEE
What are the official names of this protein?
UPF0473 protein SPCG_0207.
What is the protein family that this protein belongs to?
Belongs to the UPF0473 family.
Protein: NSRR_ECO7I
Sequence: MQLTSFTDYGLRALIYMASLPEGRMTSISEVTDVYGVSRNHMVKIINQLSRAGYVTAVRGKNGGIRLGKPASAIRIGDVVRELEPLSLVNCSSEFCHITPACRLKQALSKAVQSFLTELDNYTLADLVEENQPLYKLLLVE
What is the function of this protein?
Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress.  May require iron for activity.
What are the official names of this protein?
HTH-type transcriptional repressor NsrR.
Protein: NU4LC_MORIN
Sequence: MMLEHVLVLSAYLFSIGIYGLITSRNMVRALMCLELILNAVNINFVTFSDFFDSRQLKGNIFSIFVIAIAAAEAAIGPAIVSSIYRNRKSTRINQSNLLNK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic, NAD(P)H dehydrogenase subunit 4L, NADH-plastoquinone oxidoreductase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: TBL45_ARATH
Sequence: MAAVQCLTFLFLFLLQNATSASPLPLFRRPIQSNHSNFVKHPRRSQVVFPVNHSSCDLFAGEWVRDETYPLYRSKECGRGIIDPGFDCQTYGRPDSDYLKFRWKPFNCNVPRFNGVKFLQEMRDKTIMFVGDSLGRNQWESLICMISSSAPSINTHIIHEDPLSTFKILDYNVKVSFYRAPYLVDIDKINGKTTLKLDEISVDASNAWRTADVLLFNTGHWWSHTGSLRGWEQMETGGRYYGDMDRLVALRKGLGTWSSWVLRYINSPLTRVFFLSVSPTHYNPNEWTSRSKTSTITQGGKSCYGQTTPFSGTTYPTSSYVNQKKVIDDVVKEMKSHVSLMDITMLSALRVDGHPSIYSGDLNPSLKRNPDRSSDCSHWCLPGLPDTWNQLFYAALLY
What is the function of this protein?
May act as a bridging protein that binds pectin and other cell wall polysaccharides.  Probably involved in maintaining esterification of pectins (By similarity).  May be involved in the specific O-acetylation of cell wall polymers (By similarity).
What are the official names of this protein?
Protein trichome birefringence-like 45.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: IF5A3_ARATH
Sequence: MSDDEHHFESSDAGASKTYPQQAGNIRKGGHIVIKGRPCKVVEVSTSKTGKHGHAKCHFVAIDIFTSKKLEDIVPSSHNCDVPHVNRVDYQLIDISEDGFVSLLTDNGSTKDDLKLPTDEALLTQLKNGFEEGKDIVVSVMSAMGEEQMCALKEVGPK
What is the function of this protein?
The precise role of eIF-5A in protein biosynthesis is not known but it may function as a bimodular protein capable of binding to both RNA and proteins.  Involved in supporting growth and plays a regulatory role in the response to sub-lethal osmotic and nutrient stress.
What are the official names of this protein?
Eukaryotic translation initiation factor 5A-3, AtELF5A-3, eIF-5A-3.
What is the protein family that this protein belongs to?
Belongs to the eIF-5A family.
Protein: ARLY_CERS5
Sequence: MSDAPVSSSAANAMWGGRFAAGPDAIMQAINASIGFDKRLYAQDIRGSRAHAAMLAAQGILSSRDAEAIGEGLLTVLSEIEAGGFPFRVGLEDIHMNVEARLKELIGEPAGRLHTARSRNDQVAVDFRLWVRDQCDAAITGIEALMQAFVAQAEAGADWVMPGFTHLQTAQPVTWGHHMLAYVEMLARDRSRFADARARMNECPLGAAALAGTGFPIDRHMTAAALGFDRPTANSLDSVSDRDFALEFLSASAICALHLSRFAEELVIWSSAQFRFVRLSDRWTTGSSIMPQKKNPDAAELLRAKLGRVLGAAVALFTVMKGLPLTYSKDMQEDKEQVFDAADTLMLGLAAMTGMVADMQANRESLAAAAASGFSTATDLADWLVRELDLPFRDAHHVTGTLVARAEARGCDLPDLTLAEMQEVHPGIREDVFAVLGVANSVRSRTSYGGTAPDNVRAQAARWKELLGGTA
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT1B1_ARTSF
Sequence: MADKKPDEQFVGSGPKETKWQSFKGFVWNSETSQFMGRTAGSWAKITIFYVIFYTLLAGFFAGMLMIFYQTLDFKIPKWQNKDSLIGANPGLGFRPMPPEAQVDSTLIQFKHGIKGDWQYWVHSLTEFLEPYETLTSSGQEFTNCDFDKPPQEGKACNFNVELLGDHCTKENNFGYELGKPCVLIKLTDFGWRPEVYNSSAEVPEDMPADLKSYIKDIETGNKTHMNMVWLSCEGETANDKEKIGTITYTPFRGFPAYYYPYLNVPGYLTPVVALQFGSLQNGQAVNVECKAWANNISRDRQRRLGSVHFEIRMD
What is the function of this protein?
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.  The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
What are the official names of this protein?
Sodium/potassium-transporting ATPase subunit beta, Sodium/potassium-dependent ATPase beta subunit.
What is the protein family that this protein belongs to?
Belongs to the X(+)/potassium ATPases subunit beta family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein.
Protein: FET5_YEAST
Sequence: MLFYSFVWSVLAASVALAKTHKLNYTASWVTANPDGLHEKRMIGFNGEWPLPDIHVEKGDRVELYLTNGFQDNTATSLHFHGLFQNTSLGNQLQMDGPSMVTQCPIVPGQTYLYNFTVPEQVGTFWYHAHMGAQYGDGMRGAFIIHDPEEPFEYDHERVITLSDHYHENYKTVTKEFLSRYNPTGAEPIPQNILFNNTMNVTLDFTPGETYLFRFLNVGLFVSQYIILEDHEMSIVEVDGVYVKPNFTDSIYLSAGQRMSVLIKAKDKMPTRNYAMMQIMDETMLDVVPPELQLNQTIQMRYGHSLPEARALNIEDCDLDRATNDFYLEPLIERDLLAHYDHQIVMDVRMVNLGDGVKYAFFNNITYVTPKVPTLTTLLTSGKLASDPRIYGDNINAQLLKHNDIIEVVLNNYDSGRHPFHLHGHNFQIVQKSPGFHVDEAYDESEQDEMTVPYNESAPLQPFPERPMVRDTVVLEPSGHVVLRFRADNPGVWYFHCHVDWHLQQGLASVFIEAPVLLQEREKLNENYLDICKAADIPVVGNAAGHSNDWFDLKGLPRQPEPLPKGFTTEGYLALIISTIIGVWGLYSIAQYGIGEVIPNDEKVYHTLREILAENEIEVSRG
What is the function of this protein?
Iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake.  May be required to oxidize Fe(2+) and release it from the transporter.  Essential component of copper-dependent iron transport.
What are the official names of this protein?
Iron transport multicopper oxidase FET5.
What is the protein family that this protein belongs to?
Belongs to the multicopper oxidase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: ACCD_SULSY
Sequence: MGLKDFVDKLKNIKKSRIKIEEGAWIKCDKCKNILYIEDLLKNLKICPHCGYTFRMNAKERVDSLLDKVYSYDLFPKIKPVDIIGFKDTKRYKDRLKEAQEKTGLNDAIIIAHGNIYDREVVLASMDFNFMGGSMGSVVGAKFVRGVEFAIEKSIPFISVAASGGARMQESIVSLMQMAKTAIAIDRLNKAGILYISVLTDPTMGGVSASFAFLGDIIIAEPESLIGFAGPRVIEQTIRQQLPEGFQRAEFLLEKGQIDMVVDRKNLKKTIYTLIRHTHG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LIMKB_DICDI
Sequence: MDSRCGVCKYIISDCERYVSDNTFYHVKCFICKICKCELPPCFRGKHASLMCGDCEIKLNAPKCFKSHFPIHSVSVVARNKEFHNNCFTCISCNEIIKGGFQYSDELFYCSKCDIIKPPPLPPPLIYKAPIATSKATTSITSPLPTKIPILSTANLIPPLSSSSPLATQISPKTSTIATTTVETTTAETTLPSPFKISQLKNSGDNIYSLSSPSSSSSSSSSSSSSSSSPPNTFNKSSDFLRNPLNNNVKSSSSSIGGNFVNKSQQQQQPIDSCSKSSISISPSSPRPTEDDIKEQVFLLQKQSVQLQIQQQLQQRQIEQLNKNQLGVQKPLNQQPQQQQQQFKPQSPNLSNNDTLDSFSNLNQSLPPPPLINTTTFSNPLLKTKNQSFPTPPTSHIIKENQSQQIPKPSSIDEVDQLPLPPPPITPIPSPSSSSIIINNQQQQQQESQLPPPPPTSIIIDQSILLPPPPPSTEILPQQQSPKLYKPRPKPIVLPPPPLDMEQLPLPPPPLLSSQINQSLKSTQHNQTTSPTIEIPIPPPLPIQKQSIPTRKPQLPQSSNPSPPSPPSPQPSSNIPPLSPKQQQEQQVEPIFSPTGSIIPTPPPPPPIFKMKPLRPQKFRAPTNYIPSLSLHRANKLSNSTEDHIKPPESLVLESSRIEKFEPTINGRKLTELLKHQTFDDIVGEVLNKRISIYKQLVKDDVIFGDVIAAGASGKVYKGIYKGRDVAIKVYSSENFCFNIDEFDREVTIMSLIDSDHPNFTRFYGANKQNKKYLFHVSELVKSGSLRDLLLDKEKPLLYFTQLSIASDIANAMKHLHSIGVIHRDLKSLNVLITEDFTAKVIDFGTSRNVDLAKHMTMNLGTSCYMSPELFKGNGYDETCDVYAFGIVLWEIIARKEPYENINSWSIPVMVAKGDRPTIPADCPSEYSKLIKACWTDKPKKRPSFKEICDTLKKISESLTLKRNKK
What are the official names of this protein?
Probable LIM domain-containing serine/threonine-protein kinase DDB_G0286997.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Protein: TMCA_METKA
Sequence: MPDKAEVFFDEGVLDFADVDEIVLDVGEEALAEALAHRHRRMIVFQGDEGKAEAAGVVTAGAADVLFDVRDRPISVLYVTDSLKEDTYARERYEEFRRVLEGFAEEANFEYELEALTFSGSKRALGTTWDLMVIDLSYDLDPDAIGRLVETVRGGGLVIFQTPPFDRWRNMWTAFHKSLVTPPYTLDHVGKRFNRRFIRKLKEHDGVWIVDTDEWTAEPEPSEDVDLEVEVKRRERPDLDPPDDAVLPEELYRMCATEDQFRALIRFEELLESNGKTALILTADRGRGKSALLGIAVAGAGVTTDVYDVVVTASEPENVAVLFEFLLEALRELGVEYDVERDDKGNIVYVETDDFVVEYERPSEASEIECDLMVVDEAASIHVPILERILDNNDKVVYSSTIHGYEGAGRGFSVRFLQNVRKRRDVRLIEFKMHEPIRYDSDDPIERWLFDTLLLDAEPADLDKEDLECVKEMRVEFEKPDLRYWFEDPEGEEELRQFIGIYVMAHYRNRPSDVMVLADAPHHEAYALKTETGKIVTALQVAREGTIPRDVITKMRRGYRPPGNVIPDLMVQHHDALDFPRMKGLRIVRIATHPDIMRHGLGSRALKELAKIAKKKDYDWIGTGFGANEELTRFWLRNGFVPVHISPNRNPVSGEYSVAVIRPISEEAEEIINRANFEFRIKLADWLGETHRDLEPEVARLLFEPMSSLRYRPTLTEGQLRRLKKYADMVHTYEIAADAVRELAKAYFLDTEDRPELSEEEELLLITKCLQRWKWADVADVLGEEVPDLMRSLRDLVGLLYEEYKEDLQRSAAVEGIRKAVERLADKGLTGTVIVEVEEGEPKEVIIRREERLEL
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
What are the official names of this protein?
tRNA(Met) cytidine acetyltransferase TmcA.
What is the protein family that this protein belongs to?
Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EFG_BARQU
Sequence: MAREYKIEDYRNFGIMAHIDAGKTTMTERILFYTGKNHKIGETHDGASTMDWMEQEQERGITITSAATTTFWKGPDGRKRRFNIIDTPGHVDFTIEVERSLRVLDGAIALLDANAGVEPQTETVWRQAEKYRVPRMVFVNKMDKIGADFYRSVEMVGSRLGAKALVLQLPIGAENDFEGVVDLVYMRALRWDGSIGAPATVSEIPSDLKEKAEEYREKLIEMAVEVDEVATESYLEGVMPTDEQLVALIRKGTIEVQFHPVLCGTAFKNKGVQPLLDAVISYLPSPVDVPAISGIDVKTEDEVTRESSDDAPLSMLAFKIMNDPFVGSLTFCRIYSGKVQKGISLENTVKKKRERLGRMLQMHSNSREDIEEAFAGDIVALAGLKETTTGDTLCDPLRPVVLERMEFPEPVIEIAIEPKTKADQEKMGIALNRLAAEDPSFRVKSDEESGQTIIAGMGELHLDIIVDRMRREFKVEANIGQPQVAYRESITKAAEIDYTHKKQSGGAGQFARVKIIFEPHDGDDFIFESKIVGGAVPKEYIPGVQKGIESVMGSGPLAGFPMLGVKATLVDGGYHDVDSSVLAFEIAARAAFRDGAKKAGAQLLEPIMKVEVVTPEDYVGDVIGDLNSRRGQISGTEARSVSTVVNAMVPLANMFGYVNSLRSMSQGRAQYTMQFDHYEPVPSAVALEIQKKYA
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YHP4_SCHPO
Sequence: MPLFLEEHAEYLKRYLEQALEPISDADASVLSDYAMALLRHDSSEEEVRQLCYSQLEDFLRQETIPFVDKIFDVLREKSYLEGASNMPSTGMVTEEVSRYSPTSSMIPATNSMETNFNNSLPAVGKTNTFPSQVPNMFGPPLYHPAATAPSEFMPSIPGFGNLPNPAMPPIPFLPFNPAAQPPFPPPFKMRGKRGFGMRHEHNSELRRHSPGNRRFNPYKAYPQPHLGHRFSRNAGNDPTSTALEVRNIPEEHFNEENIRSFFSKFGVLEKVELNPTHHSCVLEFTSHEAANNAWSSPEPIFNNRFIKIFWYNPSKGFHNRPKKFASHKSPTTSDSSNVESSEDVDPASLLQNEEFHKLIEERQRQHEERLKRINANKKALEELNQKKRELAQQQLKEQELLMQKIKETDRSGNKRLMLLETQHSLLKAEADCLGLPVSNVSESPAASNGSHHPYASGLPQRGTNTFFRGRGRGRGDMFASMSIDNRPTKLRVINVSPEKNEALLQYLFTVGGYEEITEPSTTERLISFQNRNSAEKFFGGVRNVEKLQELELAWVPKTAVTTNTTSMETGESNTSDNMNIEVEEGRWR
What are the official names of this protein?
Uncharacterized RNA-binding protein C902.04.
Protein: BABA1_MOUSE
Sequence: MEVAEANSPTEEEEEEEEEGEETISEPRPHTRSNPEGAEDRALGAQASVGSRSEGEGEAATADGGAASVPGAGPKPWQVPASASEVQIRTPRVNCPEKVIICLDLSEEMSVPKLESFNGSRTNALNVSQKMVEMFVRTKHKIDKSHEFALVVVNDDSAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDIVYIHNGTEEKEEDMSWKDMFAFMGSLDTKGASYKYEVALAGPALELHNCMAKLLAHPLQRPCQTHASYSLLEEDEEAGEEEATV
What is the function of this protein?
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs).  The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.  In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs.  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates.  In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component.  The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.  Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression.  Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination.
What are the official names of this protein?
BRISC and BRCA1-A complex member 1, Mediator of RAP80 interactions and targeting subunit of 40 kDa, New component of the BRCA1-A complex.
What is the protein family that this protein belongs to?
Belongs to the BABAM1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein: PVK2_DERCR
Sequence: GSLTGLISMPRT
What is the function of this protein?
Mediates visceral muscle contractile activity (myotropic activity).
What are the official names of this protein?
Periviscerokinin-2, DerCr-PVK-2.
What is the protein family that this protein belongs to?
Belongs to the periviscerokinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ZAPB_SHEB5
Sequence: MSLELLSKLETKIQAALETIELLKMELEEEKQKASTLSEHNQQLNAQNQQLQEELTSWNEKVTGLVGLLNSEI
What is the function of this protein?
Non-essential, abundant cell division factor that is required for proper Z-ring formation.  It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle.  Its recruitment to the Z-ring requires functional FtsA or ZipA.
What are the official names of this protein?
Cell division protein ZapB.
What is the protein family that this protein belongs to?
Belongs to the ZapB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the septum at mid- cell, in a FtsZ-like pattern.
Protein: RL23_CARHZ
Sequence: MKNPRDIIIRPLITEKSMDLAQENKYTFIVDKNANKIEIKNAIEELFKVKVEKVNTIRVKGKMKRVGRFVGRTPEYKKAIVKLRAGDKIELFEGV
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PILB_ACIAD
Sequence: MISESQGGLMSAFTTPPKFSGFIRRLVEEGYVNAQNMQQALEKAKKFKQDIVPYLIDNFSISPLTIAEIISLEFGEPLLDLGVFDPALFLKDKIDEKLIQKYRIMPLVHRGHVLYVATSNPTNIEAMDAIRFNSKLKVEPIIVEHDKLERLLSEHFVEETHFNFDTEELDLDVEVDPHTTDDDDEDDKLKDEAPIVKYINKLLIDAIRMSASDLHFEPYEKSYRVRYRVDGVLRLIATPPLQLATRLASRLKVMSQMDISEKRVPQDGRIKLKMSKSKTIDFRVNSLPTLFGEKIVLRILDPASAMLGIDALGYEPEQKALFMEALNKPQGMLLITGPTGSGKTVSLYTGLNILNTEHANISTAEDPVEINLEGVNQVNVNPKVGLTFAAALRSFLRQDPDIIMVGEIRDLETAEIAIKAAQTGHLVMSTLHTNNAAETLTRLRNMGVASFNIATSVNLVIAQRLARRLCSQCKRPIQVPERSLLEMGFTPEDLAQPEFQIFEPVGCHDCREGYKGRVGIYEVMKITPEISKIIMEDGNALEIAATAETLGFNNLRRSGLKKVMQGVTSLQEINRVTSE
What is the function of this protein?
ATPase component of the type IV pilus (T4P) (By similarity).  Acts as a molecular motor to provide the energy that is required for biogenesis of the pilus and the extrusion of substrates generated in the cytoplasm (By similarity).  PilB is required for optimal T4P extension and, consequently, efficient natural transformation.  May promote processive T4P extension (PubMed:34145281).
What are the official names of this protein?
Type IV pilus assembly ATPase PilB.
What is the protein family that this protein belongs to?
Belongs to the GSP E family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIM1_CLOB1
Sequence: MKNKNVIQKMREKTPLIHCITNYVTINDCANILLSFGASPAMCEAYDEVYDFVSISSALYINLGTLTKEQETAAVLASISAKNHNVPVVIDPVGCPAIKRKVEVINRIAEVGRIDIIKGNIGEIKFLAGMDSETRGVDSLDNGENALDACTQLAKKYNCIVAATGEKDFVSDGKRGSVIKNGTEMLTKVTGAGCMLGALCAATCANFEDKLVSTTAAILSMNIAGEKAYEEAQLPGSFRIALIDNIYMISDEEIWERGNVEWK
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase 1, 4-methyl-5-beta-hydroxyethylthiazole kinase 1, TH kinase 1, Thz kinase 1.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: TRUA_BUCAP
Sequence: MKEKKNKKFALGVEYDGSYYHGWQSQKGLSTIQSEIEKALSKIANHQVNVICAGRTDSGVHSIGQVIHFTSISFRSDFSWIVGVNSYLSKNISVKWIKEVSENFNARYSAISRSYRYIIYNHKCRSAIFRNRSNHVYKELNVDKMYFEAQSLLGEHDFSSFRSSGCQSRSPFRTITDLNIRRLKNLVIIDITANSFLYHMVRNIVGSLIQINDNTKKNYIKKILDKKDRNYAGPTVSARGLYLFFVKYPMCFNLPIFKDDFII
What is the function of this protein?
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase A, tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I.
What is the protein family that this protein belongs to?
Belongs to the tRNA pseudouridine synthase TruA family.
Protein: QUEA_LYSSC
Sequence: MRVEDFDFELPEELIAQTPLVDRTASRLMVVTPGSNEVEHQHFAHVLEELRTGDCLVLNDTRVLPARLMGVKEETGAHIEVLLLKQLPGTDEWETLVKPAKRVKVGTVITFGDGLLTATCTGELDHGGRTFEFHYDGIFFEILEQLGEMPLPPYIREKLEDKDRYQTVYAKERGSAAAPTAGLHFTEELLEQVKAKGVEVVFITLHVGLGTFRPVSVDSIENHEMHAEFYSVTEEAADTINRVKRNGGKIIAVGTTSTRTLETIGSKYDGEVRAEQGWTSIFIYPGYTFTVVDGLITNFHLPKSTLVMLVSTLATRETILSAYQQAVEEKYRFFSFGDAMFIRPKE
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPI8_YEAST
Sequence: MRIAMHLPLLLLYIFLLPLSGANNTDAAHEVIATNTNNWAVLVSTSRFWFNYRHMANVLSMYRTVKRLGIPDSQIILMLSDDVACNSRNLFPGSVFNNKDHAIDLYGDSVEVDYRGYEVTVENFIRLLTDRWTEDHPKSKRLLTDENSNIFIYMTGHGGDDFLKFQDAEEIASEDIADAFQQMYEKKRYNEIFFMIDTCQANTMYSKFYSPNILAVGSSEMDESSYSHHSDVEIGVAVIDRFTYYCLDFLEQIDKNSTLTLQDLFDSFTFEKIHSHVGVRTDLFDRNPSEVLITDFFANVQNVIPDDSKPLSVSHYHHYKDHIDTAQYELNNNVLDLALETYRKNNQSSKIEKKIKDIKSTSVLDVDIDSNECFFTSFKQSATIILALIVTILWFMLRGNTAKATYDLYTN
What is the function of this protein?
Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI.  During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
What are the official names of this protein?
GPI-anchor transamidase, GPI transamidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C13 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.