PharMolix/UniProtQA huggingface dataset:
Protein: TIM54_ASPOR
Sequence: MPNFRLKLPSRNWMIFLTVTGSFTAALVYDRKQKKRAQQKWCDLVAHLSKESLPVDQTRRKLTVFLSAPPGDGLRVAREHFKEYVKPILVAAALDYQVIEGRREGEIRAGLAERIRKFRRKSGEPSTVVEETGIEEVVADAREKIGVVEEPVPKGDLIIGRNTWKEYIRGLHEGWLGPLDPPQPPLSTDVPSPSEGAETNGSPDDTPTAENSEKKEEPEKKDEKPSKPTGPTPAYITPADYSSQSLPRSLPQSLDGSVPIQFPHILGFLNTPIRIYRYLNQRYLADSVGREVAGIVLASTTRPYSDGSFSTDSELTPAGIDGAPASDNLLGGNYEQKTLLEEEEKDWHKSAHKKDEANPDKEREWVDSVVLDPRIAARMQRYVLSPEDEARSQRIAEGAEYILGEERPTPVPFWQRMWIKYGYGEDEETLKRKPIIGNIDGEDDQ
What is the function of this protein?
Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane.  The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
What are the official names of this protein?
Mitochondrial import inner membrane translocase subunit tim54.
What is the protein family that this protein belongs to?
Belongs to the TIM54 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Single-pass membrane protein.
Protein: NRPC1_ARATH
Sequence: METKMEIEFTKKPYIEDVGPLKIKSINFSVLSDLEVMKAAEVQVWNIGLYDHSFKPYENGLLDPRMGPPNKKSICTTCEGNFQNCPGHYGYLKLDLPVYNVGYFNFILDILKCICKRCSNMLLDEKLYEDHLRKMRNPRMEPLKKTELAKAVVKKCSTMASQRIITCKKCGYLNGMVKKIAAQFGIGISHDRSKIHGGEIDECKSAISHTKQSTAAINPLTYVLDPNLVLGLFKRMSDKDCELLYIAYRPENLIITCMLVPPLSIRPSVMIGGIQSNENDLTARLKQIILGNASLHKILSQPTSSPKNMQVWDTVQIEVARYINSEVRGCQNQPEEHPLSGILQRLKGKGGRFRANLSGKRVEFTGRTVISPDPNLKITEVGIPILMAQILTFPECVSRHNIEKLRQCVRNGPNKYPGARNVRYPDGSSRTLVGDYRKRIADELAIGCIVDRHLQEGDVVLFNRQPSLHRMSIMCHRARIMPWRTLRFNESVCNPYNADFDGDEMNMHVPQTEEARTEAITLMGVQNNLCTPKNGEILVASTQDFLTSSFLITRKDTFYDRAAFSLICSYMGDGMDSIDLPTPTILKPIELWTGKQIFSVLLRPNASIRVYVTLNVKEKNFKKGEHGFDETMCINDGWVYFRNSELISGQLGKATLGNGNKDGLYSILLRDYNSHAAAVCMNRLAKLSARWIGIHGFSIGIDDVQPGEELSKERKDSIQFGYDQCHRKIEEFNRGNLQLKAGLDGAKSLEAEITGILNTIREATGKACMSGLHWRNSPLIMSQCGSKGSPINISQMVACVGQQTVNGHRAPDGFIDRSLPHFPRMSKSPAAKGFVANSFYSGLTATEFFFHTMGGREGLVDTAVKTASTGYMSRRLMKALEDLLVHYDNTVRNASGCILQFTYGDDGMDPALMEGKDGAPLNFNRLFLKVQATCPPRSHHTYLSSEELSQKFEEELVRHDKSRVCTDAFVKSLREFVSLLGVKSASPPQVLYKASGVTDKQLEVFVKICVFRYREKKIEAGTAIGTIGAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRINEIINASKNISTPVISAELENPLELTSARWVKGRIEKTTLGQVAESIEVLMTSTSASVRIILDNKIIEEACLSITPWSVKNSILKTPRIKLNDNDIRVLDTGLDITPVVDKSRAHFNLHNLKNVLPNIIVNGIKTVERVVVAEDMDKSKQIDGKTKWKLFVEGTNLLAVMGTPGINGRTTTSNNVVEVSKTLGIEAARTTIIDEIGTVMGNHGMSIDIRHMMLLADVMTYRGEVLGIQRTGIQKMDKSVLMQASFERTGDHLFSAAASGKVDNIEGVTECVIMGIPMKLGTGILKVLQRTDDLPKLKYGPDPIIS
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Forms the polymerase active center together with the second largest subunit.  A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III.  A bridging helix emanates from NRPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.
What are the official names of this protein?
DNA-directed RNA polymerase III subunit 1, DNA-directed RNA polymerase III subunit RPC1, DNA polymerase I subunit C1, Nuclear RNA polymerase C1.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS14_PROM0
Sequence: MAKKSMIAREVKRKKLVKKYAAKRKSLLDEFNAAKDPMERLEIHRKIQGLPRNSAPNRVRNRCWATGKPRGVYRDFGLCRNQLRQRAHNGELPGLVKSSW
What is the function of this protein?
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
What are the official names of this protein?
30S ribosomal protein S14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS14 family.
Protein: NS7B_CVFE3
Sequence: MIVVVLVCIFLANGIKATAVQPDLHEHPVLTWDLLQHFVGNTLYITTHQVLALPLGSRVECESVDGFNCTRPGFQNSAHDHIDFYFDLSNPFYSFVDNFYIVVEGNQKINLRLVGAVPKQKRLKLSYKATRCLKLVFPRNYWSSRCLLLYRMVSTCNGRYKQPHCILGSLDLIWQC
What are the official names of this protein?
Non-structural protein 7b, ns7b, Accessory protein 7b.
Protein: RSMH_TRIEI
Sequence: MNHIPVLSSELISGLVIRPRGLYLDATLGFGGHTKLILAAAPEVKVVAIDQDKQALDSSQTLLASYNSNIQFCHSNFADYDPQNLKFDGILADLGINSVQLDTPERGFSFRHQGKLDMRMNQQQTITAAKIINHWEEVKLANIFYTYGEERLSRRIARKIIESRPLETTTELAEVVANCVPYKYRYGRIHPATRVFQALRIEVNQELSRLETFLKNAPHWLKIGGRIGIISFHSLEDRLVKHSLRNASILKVLTKKPIQPQDNEVAINPRARSAKLRLAEKLS
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RIMP_FLAPJ
Sequence: MAFKEKVKELLEQGLAEYPNLFLIDLNINDSNKIIITLDGDNGVQLQDCINISRSIDNNLDREEVDFALEVASAGVSLPLKLVRQYKKNIGRTLKIKTATQTIEALLLEVSDQDITVEWSSREPKKIGKGKETVVHNEKIAYAAIQEAIVIIIF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPIA_VIBCH
Sequence: MTQDEMKKAAGWAALKYVEKGSIVGVGTGSTVNHFIDALGTIKDEIKGAVSSSIASTAKLEALGIRVYDCNDVSELDIYVDGADEINPERDMIKGGGAALTREKIVAAIAKKFVCIVDGTKAVDVLGNFPLPVEVIPMARSYVARELVKLGGDPVYREGVITDNGNVILDVYNMKITHPKDLESKINGIAGVVTVGLFAHRGADVVITGTPQGAKIEE
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: YHAM_SALEP
Sequence: MFESKINPLWQSFILAVQEEVKPALGCTEPISLALAAAAAAAELDGTVERIDAWVSPNLMKNGMGVTVPGTGMVGLPIAAALGALGGDAKAGLEVLKDASAKAVADAKAMLAAGHVAVMLQEPCNDILFSRAKVYSGDSWACVTIVGDHTNIVRIETNKGVVFTQADNAQEEEKNSPLGVLSHTSLEEILAFVNAVPFDAIRFILDAARLNGALSQEGLRGSWGLHIGSTLAKQCDRGLLAKDLSTAILIRTSAASDARMGGATLPAMSNSGSGNQGITATVPVMVVAEHVGADDERLARALMLSHLSAIYIHHQLPRLSALCAATTAAMGAAAGMAWLIDGRYDTIAMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHNVEQSIANLCSLACRSMQQTDKQIIEIMASKAH
What are the official names of this protein?
UPF0597 protein YhaM.
What is the protein family that this protein belongs to?
Belongs to the UPF0597 family.
Protein: TAF4_SCHPO
Sequence: MDLNNPPSKRFGDDDDIPANKRPKNEEYPEIPGYLGNRKPSYTQNPNSGPGKLHYASPRPNNVSSSVGVASGGDRQEADQLQDALISCGIQLKEEELNLSTSFYDPSSLNTFALTTEDRSRKSDFLNSFVLMQTVSNIVNLHRLKSMDSDIHALISMAVRDYLANLLQKMIVESHHRTSQLHTDNYKQVDNVRQTLANFAYKEYESEERRRTVLNIRRAEHEARLAELNSASTNEEGSSRRRKEQSSSAAAKNISEDAQNRMTNATASIMAGSALPSGGKKYSWMATDMTPMTPAVGGGFGIRKKDSNSLKPSSRDGVLPLQQEEKGIITIRDALAVLEMDREGAGRIFGRGAKAMMRAYIRLKD
What is the function of this protein?
Functions as a component of the DNA-binding general transcription factor complex TFIID.  Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation.  TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by taf1), facilitation of DNA opening and initiation of transcription (By similarity).
What are the official names of this protein?
Transcription initiation factor TFIID subunit 4, TBP-associated factor 4.
What is the protein family that this protein belongs to?
Belongs to the TAF4 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GAB1_HUMAN
Sequence: MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
What is the function of this protein?
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases.  Plays a role in FGFR1 signaling.  Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).  Involved in the MET/HGF-signaling pathway (PubMed:29408807).
What are the official names of this protein?
GRB2-associated-binding protein 1, GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1.
What is the protein family that this protein belongs to?
Belongs to the GAB family.
Protein: MUKF_VIBA3
Sequence: MSEMTQTAEEQPIDELVGWVKQHDFSLNLPPERLAFLIAIAVLSNERFDEELGEGELHDAFTIVTRLFEDTGEASAFRANNAINELVKQKLISRFTSEITDGASIYRLSPLAIGISDYYLRHRQFSKLKLSIQLSMVADEMAKAIEAAQKGGTPGHWRRNVYGVLKYSVGEIFDQIDLNQRVMDEQQQTVKQQIADLLNKDWREAINNCESLLSETSATLKELQDTLQAAGDELQTQILDIQEIVYGDDELEFVGETLFGLQMKLDRITSWGQQAIDLWIGYDRHVHKFIRTAIDMDKNRAFSQRLRQSVTDYFDAPWLLTYADAEKLTDLRDEALVLRDDEVMGQAPIDVEYEEFEQVNDLLSERIGDMLKAHKQQGAPIDLGLVLRDYLAAHPRTHHFDLARIVVDQAVRLGYSESDYQAIQPDWQAINDFGAKVQANVINKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: NCLN_DANRE
Sequence: MFEEAGEVLENMLKVSFPLSLVLFLVLVCPLRAEAAHEFSVYRMQQYDLQGQTYGSRNAILNTEARTVEAEVLSRRCVMMRLADFSYEKYQKALRQSAGAVVIILPHNMSTLPQDIVQQFMELEPELLATETIVPVYFALEDEELLSIYTQTQISSSSQGSSSAAEVLLHTATANGFQMVTSGAQSKAVSDWAITSLEGRLTGSGGEDLPTIVLVAHYDSFGVAPWLSYGADSNGSGVAILLELARLFSRLYSYKRTHAGYNLLFFLSGGGKFNYQGTKRWLEDNLDHTDASLLQDNVAFVLCLDTLGNSDNLHLHVSKPPKEGSPQYTLLKELETVVAHQHPDLKFAMVHKKINLADDTLAWEHERFGIRRLPAFTLSHLESHRSPARHSIMDMRSVSPSLEGAGEATTGPHVDLGKLSRNTKVIAETLARVIYNLTEKGVTGDLEIFTEQMQVQEDQLASLVDWLTAQPRAAQLLDKDSSIINTLEHQLSRYLKDVKRHLVRADKRDPEFVFYDQLKQTMNAYRVKPAIFDLLLAVCIASYLGVLYLAIQNFGLLYGFLRRVTAPRVKQH
What is the function of this protein?
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes.  The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity).  Antagonizes Nodal signaling and subsequent organization of axial structures during mesodermal patterning.  Ectopic expression results in cyclopia, due to a defect in mesendoderm patterning (PubMed:15257293).
What are the official names of this protein?
BOS complex subunit ncln, Nicalin-1, Nicastrin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the nicastrin family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: RE104_YEAST
Sequence: MSIEEEDTNKITCTQDFLHQYFVTERVSIQFGLNNKTVKRINKDEFDKAVNCIMSWTNYPKPGLKRTASTYLLSNSFKKSATVSLPFILGDPVCMPKRVESNNNDTCLLYSDTLYDDPLIQRNDQAGDEIEDEFSFTLLRSEVNEIRPISSSSTAQILQSDYSALMYERQASNGSIFQFSSP
What is the function of this protein?
Potential transcriptional regulator that is required to activate expression of a number of early meiotic genes including HOP1.
What are the official names of this protein?
Meiotic recombination protein REC104.
Protein: ECFA1_STAAW
Sequence: MEDKNSVIVFKNVSFQYQSDASFTLKDVSFSIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQTITDDNFEKLRKDIGIVFQNPDNQFVGSIVKYDVAFGLENHAVPHDEMHRRVGEALKQVDMLERADYEPNALSGGQKQRVAIASVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAMEADHVIVMNKGTVYKEGTAIEIFDHAEELTTIGLDLPFPIKINQMLGYQTSFLTYEGLVDQL
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA1, ECF transporter A component EcfA1.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RBFA_AZOSB
Sequence: MPKEYSRSQRVVEQIRRELAELIRLEVKDPRVGFITLTDVEISPDYAHAKVFFTSMTGEESVPEILQGLRRASGFLRRELGRRVRIHTTPELHFHYDRSVEEGSRLSRLIDDAVREDEIRHRDDDN
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NRDJ_STRCO
Sequence: MTETASGPARSSRAKGTKAGKGLRVERVHTTPGVHPYDEVAWERRDVVMTNWRDGSVNFEQRGVEFPEFWSVNAVNIVTSKYFRGAVGTPQREVSLKQLIDRIVKTYRKAGEDNKYFASPADAEIFEHELAYALLHQIFSFNSPVWFNVGTPQPQQVSACFILSVDDSMESILDWYKEEGMIFKGGSGAGLNLSRIRSSKELLSSGGNASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEDFIQTKVKEEEKIRALRDAGFDMDLGGDDITSVQYQNANNSVRVNDTFMKAVQDGGKFGLTSRMTGEVIEEVDAKALFRKMAEAAWACADPGIQYDDTINAWHTCPESGRINGSNPCSEYMHLDNTSCNLASLNLMKFLKDDGKGNQSFDAERFSKVVELVITAMDISICFADFPTQKIGENTRAFRQLGIGYANLGALLMATGHAYDSDGGRALAGAITSLMTGTSYRRSAELAAIVGPYDGYARNAKPHLRVMKQHSDENAKAVRMDDLDTPIWAAATEAWQDVLRLGEKNGFRNSQASVIAPTGTIGLAMSCDTTGLEPDLALVKFKKLVGGGSMQIVNGTVPQALRRLGYQEEQIEAIVAHIAENGNVIDAPGLKPEHYEVFDCAMGERSISAMGHVRMMAAIQPWISGALSKTVNLPESATVEDVEEVYFEAWKMGVKALAIYRDNCKVGQPLSAKTKTVKDTEKAEITEKTEAAIRETVEKVVEYRPVRKRLPKGRPGITTSFTVGGAEGYMTANSYPDDGLGEVFLKMSKQGSTLAGMMDAFSIAVSVGLQYGVPLETYVSKFTNMRFEPAGMTDDPDVRMAQSIVDYIFRRLALDFLPFETRSALGIHSAEERQRHLETGSYEPSDDELDVEGLAQSAPRAQELVAVATPKAEAEAAKPAPQQAHTSAELVEMQLGIQADAPLCFSCGTKMQRAGSCYICEGCGSTSGCS
What is the function of this protein?
Catalyzes the reduction of ribonucleotides to deoxyribonucleotides.  May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
What are the official names of this protein?
Vitamin B12-dependent ribonucleotide reductase, Ribonucleoside-diphosphate reductase NrdJ.
What is the protein family that this protein belongs to?
Belongs to the ribonucleoside diphosphate reductase class-2 family.
Protein: THIC_SYNJA
Sequence: MRSEWVARRRGQANVTQMHFARQGVITEEMDYVARRENLPPELIRSEVARGRMIIPANINHTNLEPMCIGIASRCKVNANIGASPSSSGLAEELEKLKLAIKYGADTVMDLSTGGGDLDEIRTAIIQASPVPIGTVPIYQALESVHGNVEKLSAEDILHIIEKQAQQGVDYMTIHAGILIEYLPLVRNRLTGIVSRGGGILARWMLAHHKQNPLYTHFRDIIEIFKKYDVSFSLGDALRPGCLHDASDEAQMAELKTLGQLTRMAWEHDVQVMVEGPGHVPMDQIEFNVRKQMEECDEAPFYVLGPLVTDIAAGYDHISSAIGAALAGWYGAAMLCYVTPKEHLGLPNAEDVRNGLIAYKIAAHAADIARHRPGARDRDDEMSRARYNFDWNRQFELSLDPERAREYHDETLPADIYKTAEFCSMCGPKFCPMQTKMDAEALSELERFLAKQPTA
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: RSMG_PARL1
Sequence: MTQHIVSGGPQVVDSESFSALTNVSRETLDRLLSYEALLRKWQKSINLVSNGSLPELWRRHMLDSAQLVCLVPESARRWIDLGSGGGFPGLVIAILLRERPGFQMHLVESDQRKCVFMREVARVTGAPATVHTVRIEAFAQGAEAGDVVSARALAPLDRLFGWAAPLFGPETIGLFLKGQGLQDELTLARESWIFDAEFSPSQSDPEGSVLKVRGLHGPDGQPHRR
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL11_CROS8
Sequence: MAKKVQAYVKLQVAAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTDSMEKGLPIPVVITVYADRSFTFVTKTPPAAVLLKKAAGIKSGSGKPNKDKVGTITRAQLQEIAQTKAADMTGADIEAMTRSIEGTARSMGLVVED
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: BETI_BURM1
Sequence: MPKVGMREIRRAQLIDATLRSIDEAGLPGTTLASVAQRANISTGIVSHYFGDKDGLLEATMRHVLRDLWSATTRRRTAARKDPRSRLRAIVAANFDDTQIAAPVMKTWLAFWSQSMHDPMLKRLQHVNTRRLHSNLCAEFAKALPRAKAREAASGLAALIDGLWLRGALAGGPIDTRAALKLAHDYIDLLLASD
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: CDD_PECCP
Sequence: MHPRFENAFRQLPASLQAALRPLIDKPDFAAMLTADDVNAVCEASQLDADALAFALLPLAAACAQAPISNFQVGAIAQGLSGNFYFGANMEFSAVQLQQTVHAEQSAVSHAWMRNERGLRAVTVNYTPCGHCRQFMNELRDAASLRIQLPGRQPATLSHYLPDSFGPVDLQIDTLLMDDINHGATLQNMNALARQALDAANRSHAPYSKAISGIVLETSSGNTYTGRYAENAAFNPSLPPLQTALNLMNLAGEDLSTVKHAVVVERRNAVVSHWAISQIMLAELGCTDVEHHFIEE
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: LIP_STAES
Sequence: MKTRQNKYSIRKFSVGASSILIAALLFMGGGSAQAAEQQQDKGTVENSTTQSIGDGNEKLSEQQSTQNKNVNEKSNVNSITENESLHNETPKNEDWIQQQKDSQNDNKSESVVEQNKENEAFVQNHSEEKPQQEQVELEKHASENNQTLHSKAAQSNEDVKTKPSQLDNTAAKQEDSQKENLSKQDTQSSKTTDLLRATAQNQSKDSQSTEEINKEVNNDTQQVTAKNDDAKVESFNLNSKEEPLKVDKQANPTTDKDKSSKNDKGSQDGLANLESNAVATTNKQSKQQVSEKNEDQTNKSAKQKQYKNNDPIILVHGFNGFTDDINPSVLTHYWGGDKMNIRQDLEENGYEAYEASISAFGSNYDRAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYEGVYKDWKPGQKIHLVGHSMGGQTIRQLEELLRHGNPEEVEYQKQHGGEISPLYQGGHDNMVSSITTLGTPHNGTHASDLLGNEAIVRQLAYDVGKMYGNKDSRVDFGLEHWGLKQKPNESYIQYVKRVQNSKLWKSKDSGLHDLTRDGATDLNRKTSLNPNIVYKTYTGESTHKTLAGKQKADLNMFLPFTITGNLIGKAKEKEWRENDGLVSVISSQHPFNQKYVEATDKNQKGVWQVTPTKHDWDHVDFVGQDSTDTKRTRDELQQFWHGLAEDLVQSEQLTSTNK
What are the official names of this protein?
Lipase, Glycerol ester hydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted.
Protein: ACTP_YERPB
Sequence: MKIRHWSALSLFVLPALAQAEALTGEVHRQPLNIQAIVMFLLFVGGTLYITYWASKRTRSRQDYYTAGGRITGFQNGLAIAGDYMSAASFLGISALVYASGYDGLIYSIGFLIGWPIILFLIAERLRNLGRYTFADVASYRLQQRPIRTLSACGSLVVVALYLIAQMVGAGKLIQLLFGLNYHVAVVLVGILMVLYVLFGGMLATTWVQIIKAVMLLSGATFMAIMVMKSVNFNFNTLFSEAVKVHPKGLSIMSPGGLVSDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFIIGFGAILLVGPNQTFKDAAGALLGGNNMAAVHLANAVGGSFFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVIKKGKANERDELRVSKITVIILGIVAIGLGILFEKQNIAFMVGLAFSIAASCNFPIIIISMYWDKLTTRGAMIGGWLGLSTAVILMILGPTIWVTILGHEKPIYPYEYPALFSMIAAFVGTWFFSITDNSETGKQERLLFKSQFVRSQTGLGASKGGAH
What is the function of this protein?
Transports acetate.
What are the official names of this protein?
Cation/acetate symporter ActP, Acetate permease, Acetate transporter ActP.
What is the protein family that this protein belongs to?
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: MFS4B_RAT
Sequence: MEFRGSGATAVEQHLLQSETPGKNGLQATSSDQVGRTLRWFTTVVLNAAFLGMGVSAAVLGPTFPDLARNVNRNISSLSEIFVGRALGYLGGSVVGGVLFDCMNHFLLLGLSHLLTAAGLYLTPFCKTAALLTAMMSITGVSFGVLDTGGNVLILDLWGDKGAPHIQALHFSFALGAFLAPLLAKLAWGTTASAQNHTEPQLDRSALNRSFEAASDSVLAVPDDMNLLWAYASIGTYVLVLSVFLFAPFFKKRSKQKKSAASAQGARRAKYHRALLCLLFLFFFFYVGAEVTYGSYVFSFATTHVGMEESEAAGLNSIFWGTFAACRGLAIFFATLLQPGTMMVLCNIGSLASSFFLVLFDKSPLCLWIASSVYGASMAATFPSGISWIEQYTTLTGKSAAFILVGAALGLMATPALSGILQGHYPDLPVILYMCLGSAVLTTVLFPVMYKVATLPLDRKQEKSINSEGQKILLSSSRLIKEAK
What is the function of this protein?
May function as a sodium-dependent glucose transporter (PubMed:12590146).  Potential channels for urea in the inner medulla of kidney (PubMed:26423860).
What are the official names of this protein?
Sodium-dependent glucose transporter 1, rNaGLT1, Major facilitator superfamily domain-containing protein 4B.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily.
What are the subcellular locations of this protein?
Apical cell membrane; Multi-pass membrane protein.
Protein: Y1385_MYCBO
Sequence: MASLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEATEVAAKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVTGGRFI
What are the official names of this protein?
Uncharacterized oxidoreductase Mb1385.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: RL25_SYNC1
Sequence: MAQTELNVSQREGLGKGTARSLRREGLIPAVMYGKGVENCSLVVEPKQLAAIIGSEAGLNSLITLKGEGAFDGKVVILKDMQVDPIRQTPLHVDFQAIDLNAKTHVLVPLVVVGKSEGEKQGGNLQIIRHEVELVCLPANIPANIEVDVTALNIGDALHVQDVQLPEGVEIPQDVNFTVVTVTGRTAEVEEEGAEVVEEGEEAAEAGE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.