PharMolix/UniProtQA huggingface dataset:
Protein: RISB_BARQU
Sequence: MTKEIHKKLHVLIVEARFYDGISDALLKGAVRTLQKAGASYDIVTVPGALEIPGAIAFAEKNSKVFYNGYVALGCVIRGETYHFEIVANDSCRALMDLTVHKHLAIGNGILTVEDEKQAWVRANQDEKNKGGFAAEAALCMIALKKRFGDNH
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: YHBP_SALHS
Sequence: MDTLTAIGRWLAKQHVVTWCVHHEGELWCANAFYLFDAQNVALYLLTDDKTRHAQMSGACAPVAGTVNGQPKTVARIRGVQFKGEIRRLEGQESDAARKAYLRRFPVARVLPAPVWEIRLDEIKFTDNTLGFGKKLHWLRDSRAQQA
What are the official names of this protein?
UPF0306 protein YhbP.
What is the protein family that this protein belongs to?
Belongs to the UPF0306 family.
Protein: GSA1_LACP7
Sequence: MTRSEELFKEALKVIPGGVNSPVRAFGSVGESPRFIKRAEGAHLYDVDGKEYIDYICSWGPMILGHNHPDILESVVQACQNGLSFGAVTEMEVKMAKLICELVPSIEMVRMVNSGTEAVMSAIRVARGYTGRNKIIKFNGCYHGHSDGLLVKAGSGVMTAGVPDSLGVPKGCTEDTLTANYNDITGVQELFNQYRSDIAAVIVEPVAANMGVVLPKEGFLHGLRKLCNENGTVLIFDEVITGFRLGIDGAQGYYGVTPDLTTYGKIIGAGMPVGAYGGRKEIMEVVAPLGAVYQAGTLSGNPVAMTAGYTQLTILKENPDYYTKLNQMGELLFGDIEMKFRRAGIPFQMNHVGSLGSLFFAKEEVYDYQSAKASDTEQYKAYFKYMLNKGIYLAPAQFEAMFLSVAHGEEEIKQTLDTMDGFLESVR
What are the official names of this protein?
Glutamate-1-semialdehyde 2,1-aminomutase 1, GSA 1, Glutamate-1-semialdehyde aminotransferase 1, GSA-AT 1.
What is the protein family that this protein belongs to?
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRTL_ECOLI
Sequence: MRSFDQGSTRAPARERCRRQRPEGRSAQR
What are the official names of this protein?
Protamine-like protein.
Protein: IPSG_PANLE
Sequence: ASPPEVNCSQYNRKGSGIACSKQLKPICGIDHKTYSNECMFCLLNQNKQFQIRKLYDDKCQIECTNYSAICTMEYFPLCGSDGKVYSNKCSFCNEVVKRRGTLFLAKYGQCK
What is the function of this protein?
This inhibitor is composed of two homologous actively inhibiting halves: one which inhibits trypsin, the other which inhibits elastase.
What are the official names of this protein?
Double-headed protease inhibitor, submandibular gland.
What are the subcellular locations of this protein?
Secreted.
Protein: DRS31_PHYTB
Sequence: GLFKTLIKGAGKMLGHVAKQFLGSQGQPES
What is the function of this protein?
Has antimicrobial activity.
What are the official names of this protein?
Dermaseptin-3.1TR.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: CSN5_KLULA
Sequence: MSSIKFHEKSLKEVTRWIQANEDINTETSLSSSSDSSTTIPVIDHLPARIPYATDLKRNPCHFQKCLISRLATTKMLSHAVDGGDIEVMGMLVGYTSNDMIVVKDCYSLPVQGTETRVNAHMESYEYMVQYLDAFVTKEDKIVGWYHSHPGYGCWLSNIDIQTQSLNQNYQDPYLAIVVDPKKSLSGNTLDIGAFRTLPSKDNNEHVDYYPLNIQLYQNSLDVNISKLKLKFKVDPAIQNNPNEPELMKELHECVENWFHAKKVMKSTVGFNAIGSTVVNETEIGNEDFTHERSNSISSTSSLTTRHTTDVEMDDQESAQSSLDIPANVIPGMQFQEAEIKHEYELKKKKLLLLKVKQYQKLRTYRQLFNASE
What is the function of this protein?
Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.  The CNS complex is involved in the regulation of the mating pheromone response.
What are the official names of this protein?
COP9 signalosome complex subunit 5.
What is the protein family that this protein belongs to?
Belongs to the peptidase M67A family. CSN5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y396_STAAB
Sequence: MEYIKKLLCTMSVLLLIIFIGGCGNMKDEQKKEEQTNKTDSKEEQIKKSFAKTLDMYPIKNLEDLYDKEGYRDGEFKKGDKGTWTISTDFAKSNKPGEMDSEGMVLHLNRNTRTATGYYTIRTTYDEVGKMTREKNYRVELKNNKIVLLDKVEDENLKHKIENFKFFGQYADFKDLKNYKNGRITINENVPYYEAEYKINNSDGNVKKLRENYPITAKKSPILKLHIDGDIKGSSVGYKQIEYTFSKEKEDETFMSDFLNFGPTKGGNND
What are the official names of this protein?
Uncharacterized lipoprotein SAB0396.
What is the protein family that this protein belongs to?
Belongs to the staphylococcal tandem lipoprotein family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor.
Protein: SSRP_BACFN
Sequence: MKLAPINIKNKRATFDYELIDTYTAGIVLTGTEIKSIRLGKASLVDTFCYFAKGELWVKNMHIAEYFYGSYNNHAARRDRKLLLSKKELNKLERGTKDAGFTIVPVRLFINERGLAKVVVALAKGKKQYDKREALKEKDDRRDMDRMFKR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: ACKA_KOCRD
Sequence: MLVLVVNCGSSSIKYQVREVTPEGSEPSPYTSSMPAINENIPLATATAGMAGDQVITKGLIENIGTSEIQDHTQALEILARRLDEELGGRTIDAAGHRVVHGGERFSAPVLVNNEIIRAIERLAPLAPLHNPAHALGLRAIQKTYPGMPQVCVFDTAFHRTMPEKAWRYAIPEQWYEMDGMRRYGFHGTSHDYVTGKACEFLGIPREQFNTVVAHLGNGASVTAIREGRSYDTSMGYTPLAGLVMGTRSGDLDPSVVTAMLERKPGMSAQDMNRILNNESGLQGICGDSDMRAVEQRADSGDERAQLALDMAAYRLAKYIGGYHVAVGGAQALIFTAGIGENSPGFRALVCDQLGALGVRLDASRNEHPEGNVARISFPDSAVEVLVVATDEERAIAEATAALVWERVKN
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTCA_TRIV2
Sequence: MIVTQDKALANVFRQMATGAFPPVVETFERNKTIFFPGDPAERVYFLLKGAVKLSRVYEAGEEITVALLRENSVFGVLSLLTGNKSDRFYHAVAFTPVELLSAPIEQVEQALKENPELSMLMLRGLSSRILQTEMMIETLAHRDMGSRLVSFLLILCRDFGVPCADGITIDLKLSHQAIAEAIGSTRVTVTRLLGDLREKKMISIHKKKITVHKPVTLSRQFT
What is the function of this protein?
Has affinity for the xisA upstream region.  Binds to a 66 bp region containing three repeats of the consensus recognition sequence 5'-ACATT-3'.
What are the official names of this protein?
Global nitrogen regulator, DNA-binding protein VF1, Nitrogen-responsive regulatory protein.
Protein: RS7B_AQUAE
Sequence: MPRKGPVPPREIPPDPKYGDVLVQKLINKVMKDGKKSVAEWIVYTALEEAAKEVNMHPVELLHKVIEKLKPEWEVRPRRVGGATYQVPIEVPERRQISLAIKWLVQAARERPRGRGQYTMIERLKAELLDALNERGGAYKKKEETHRMAHANMVFSHFRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity).
What are the official names of this protein?
30S ribosomal protein S7-2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: RSD_ECOLC
Sequence: MLNQLDNLTERVRGSNKLVDRWLHVRKHLLVAYYNLVGIKPGKESYMRLNEKALDDFCQSLVDYLSAGHFSIYERILHKLEGNGQLARAAKIWPQLEANTQQIMDYYDSSLETAIDHDNYLEFQQVLSDIGEALEARFVLEDKLILLVLDAARVKHPA
What is the function of this protein?
Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA.  May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
What are the official names of this protein?
Regulator of sigma D.
What is the protein family that this protein belongs to?
Belongs to the Rsd/AlgQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UGPC_BRUSU
Sequence: MSKIVLDNVRKSYGGNIEVIKGVSLEIADGEFVVLVGPSGCGKSTLLRMIAGLESITSGTISIGERVVNNVEPAERDIAMVFQNYALYPHMTVRENLAYGLKNRKTPKEEIERRIAKAAKALEIEQFLERKPRQLSGGQRQRVAMGRAIVREPAAFLFDEPLSNLDAKLRVQMRVEIKRLQRSLGTTSVYVTHDQMEAMTMADRLVVLNAGHIEQVGTPIELYEKPASTFVATFIGSPSMNLLQSPESAAWQPGRAITLPSGGYTFGVRPEDIRILEEGDQDADGFNAQVRIEAVELVGAESYIHAALSDGKPLIFRVAGRSTHNIDEMVRVGASATDVHIFGADGRRVSD
What is the function of this protein?
Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
sn-glycerol-3-phosphate import ATP-binding protein UgpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LAPB_ECOL6
Sequence: MLELLFLLLPVAAAYGWYMGRRSAQQNKQDEANRLSRDYVAGVNFLLSNQQDKAVDLFLDMLKEDTGTVEAHLTLGNLFRSRGEVDRAIRIHQTLMESASLTYEQRLLAIQQLGRDYMAAGLYDRAEDMFNQLTDETDFRIGALQQLLQIYQATSEWQKAIDVAERLVKLGKDKQRVEIAHFYCELALQHMASDDLDRAMTLLKKGAAADKNSARVSIMMGRVFMAKGEYAKAVESLQRVISQDRELVSETLEMLQTCYQQLGKTAEWAEFLQRAVEENTGADAELMLADIIEARDGSEAAQVYITRQLQRHPTMRVFHKLMDYHLNEAEEGRAKESLMVLRDMVGEKVRSKPRYRCQKCGFTAYTLYWHCPSCRAWSTIKPIRGLDGL
What is the function of this protein?
Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis.  May act by modulating the proteolytic activity of FtsH towards LpxC.  May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.
What are the official names of this protein?
Lipopolysaccharide assembly protein B.
What is the protein family that this protein belongs to?
Belongs to the LapB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein; Cytoplasmic side.
Protein: SYK_BORBU
Sequence: MKTAHWADFYAEKIKKEKGPKNLYTVASGITPSGTVHIGNFREVISVDLVARALRDSGSKVRFIYSWDNYDVFRKVPKNMPEQELLTTYLRQAITRVPDTRSHKTSYARANEIEFEKYLPVVGINPEFIDQSKQYTSNAYASQIKFALDHKKELSEALNEYRTSKLEENWYPISVFCTKCNRDTTTVNNYDNHYSVEYSCECGNQESLDIRTTWAIKLPWRIDWPMRWKYEKVDFEPAGKDHHSSGGSFDTSKNIVKIFQGSPPVTFQYDFISIKGRGGKISSSSGDVISLKDVLEVYTPEVTRFLFAATKPNTEFSISFDLDVIKIYEDYDKFERIYYGVEDVKEEKKRAFKRIYELSQPYMPSKRIPYQVGFRHLSVISQIFENNINKILNYLKNVQEDQKDKLINKINCAINWIRDFAPEDFKFSLRSKFDNMEILEENSKKAINELLDFLKKNFEVATEQDIQNEIYKISRENNIEPALFFKQIYKILIDKEKGPKLAGFIKIIGIDRFEKITSKYV
What are the official names of this protein?
Lysine--tRNA ligase, Lysyl-tRNA synthetase, LysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHR7_CAEEL
Sequence: MQSYTNRICAVCGDTPAKIHYGVLACFGCKGFFRRAVKDGRNKYVCRFEKNCEVTKFERNACRYCRFRKCLLVGMNPDYVRPDREKSKKGKTVLSKKKSVSRSLSYRLADPSDWTSFLSPSSRKQLSEIGKLAETCSTSTNFDGIGNFSLKSLIADRSLARKTGDSEAMDCSNSPRQLNEQFLGIERIVQCVDYIDRFLVMLEEEHCRKFSVEDKSALISDTMIHLLLFESTSRFVAKGAPGLEDLKLSLAQLPICTTHLTQKIADVFETYLRKPPSIIEYSVLKAYIVLSAESTVLSNSLNESLSLARENLSELLFKVIKHSRNKTSISAANSLSTILHFVYESRNLASRIRQSQQPFFVRDSDPKIPFHKILTDIINPEVSDLLLTTANCRKLSTQMGSSLSSVPPVPPPSDTVPLFHFSPPSLSPCQISAPPPPQQQYTDYSQMPSTSSYPANSSPFQSPYRPNSLSSFPKIPLEMTKSIEEFLRPNGMTTDEMNKPLEKNWADGFRLTPVFNKDIVSQFFPELSNINQHHPF
What is the function of this protein?
Orphan nuclear receptor.
What are the official names of this protein?
Nuclear hormone receptor family member nhr-7.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family.
What are the subcellular locations of this protein?
Nucleus.
Protein: FOLD_CROS5
Sequence: MSSETASLLNGKALAQKIQGELKTTVEKLQGNIGRPPGLAVIMVGDNPASAVYVRNKEKACAKVGIASFGRHLPTETPQEEVEALIHQLNADERVDGILVQLPLPPHLDTVKLLHAIAPEKDADGLHPMNLGHLIRGEEGLRSCTPWGVMRLLEEYNLDVAGKHAVVVGRSILVGKPLALMLLEKNATVSIAHSRTPDLGEITRQGDIIIAAVGKPNLITGEMVKPEAIAIDVGINRIMTKDGASKLVGDFEFNSVSQVSSYITPVPGGVGPMTVAMLLQNTVLSYQKH
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: HELD_ECOLI
Sequence: MELKATTLGKRLAQHPYDRAVILNAGIKVSGDRHEYLIPFNQLLAIHCKRGLVWGELEFVLPDEKVVRLHGTEWGETQRFYHHLDAHWRRWSGEMSEIASGVLRQQLDLIATRTGENKWLTREQTSGVQQQIRQALSALPLPVNRLEEFDNCREAWRKCQAWLKDIESARLQHNQAYTEAMLTEYADFFRQVESSPLNPAQARAVVNGEHSLLVLAGAGSGKTSVLVARAGWLLARGEASPEQILLLAFGRKAAEEMDERIRERLHTEDITARTFHALALHIIQQGSKKVPIVSKLENDTAARHELFIAEWRKQCSEKKAQAKGWRQWLTEEMQWSVPEGNFWDDEKLQRRLASRLDRWVSLMRMHGGAQAEMIASAPEEIRDLFSKRIKLMAPLLKAWKGALKAENAVDFSGLIHQAIVILEKGRFISPWKHILVDEFQDISPQRAALLAALRKQNSQTTLFAVGDDWQAIYRFSGAQMSLTTAFHENFGEGERCDLDTTYRFNSRIGEVANRFIQQNPGQLKKPLNSLTNGDKKAVTLLDESQLDALLDKLSGYAKPEERILILARYHHMRPASLEKAATRWPKLQIDFMTIHASKGQQADYVIIVGLQEGSDGFPAAARESIMEEALLPPVEDFPDAEERRLMYVALTRARHRVWALFNKENPSPFVEILKNLDVPVARKP
What is the function of this protein?
Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP.
What are the official names of this protein?
DNA helicase IV, 75 kDa helicase, DNA 3'-5' helicase IV.
What is the protein family that this protein belongs to?
Belongs to the helicase family. UvrD subfamily.
Protein: RRP1_SCHPO
Sequence: MSAPSPFIKKLAANDRKTRDKALESLQRFLSQKKKFERLDFLKLWKGLFYCMWMADKPLYQQKLSDNLAALVPIVWIDNRILFQSTFWETMGREWTGIDILRTDKFYLLMRRFCAAAFRDIQTRSKTALLDKVVAEYNQMWMDGPFNTENLAFPNGILFHLADIWTEELRKVYPEDVPKADWYLPFDSTIKSSHNVVLRKTLPKRLDRVSEYTKDSQ
What is the function of this protein?
Required for 27S rRNA processing to 25S and 5. 8S.
What are the official names of this protein?
Ribosomal RNA-processing protein 1 homolog.
What is the protein family that this protein belongs to?
Belongs to the RRP1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: RM04_HUMAN
Sequence: MLQFVRAGARAWLRPTGSQGLSSLAEEAARATENPEQVASEGLPEPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLDILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSPLWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLELPTGDPQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIPAVGLNVHSMLKHQTLVLTLPTVAFLEDKLLWQDSRYRPLYPFSLPYSDFPRPLPHATQGPAATPYHC
What are the official names of this protein?
39S ribosomal protein L4, mitochondrial, L4mt, MRP-L4, Mitochondrial large ribosomal subunit protein uL4m.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYI_STRP2
Sequence: MKLKDTLNLGKTEFPMRAGLPTKEPVWQKEWEYAKLYQRRQELNQGKPHFTLHDGPPYANGNIHVGHAMNKISKDIIVRSKSMSGFYAPFIPGWDTHGLPIEQVLSKQGVKRKEMDLVEYLKLCREYALSQVDKQREDFKRLGVSGDWENPYVTLTPDYEAAQIRVFGEMANKGYIYRGAKPVYWSWSSESALAEAEIEYHDLVSTSLYYANKVKDGKGVLDTDTYIVVWTTTPFTITASRGLTVGADIDYVLVQPAGEARKFVVAAELLTSLSEKFGWADVQVLETYRGQELNHIVTEHPWDTAVEELVILGDHVTTDSGTGIVHTAPGFGEDDYNVGIANNLEVAVTVDERGIMMKNAGPEFEGQFYEKVVPTVIEKLGNLLLAQEEISHSYPFDWRTKKPIIWRAVPQWFASVSKFRQEILDEIEKVKFHSEWGKVRLYNMIRDRGDWVISRQRAWGVPLPIFYAEDGTAIMVAETIEHVAQLFEEHGSSIWWERDAKDLLPEGFTHPGSPNGEFKKETDIMDVWFDSGSSWNGVVVNRPELTYPADLYLEGSDQYRGWFNSSLITSVANHGVAPYKQILSQGFALDGKGEKMSKSLGNTIAPSDVEKQFGAEILRLWVTSVDSSNDVRISMDILSQVSETYRKIRNTLRFLIANTSDFNPAQDTVAYDELRSVDKYMTIRFNQLVKTIRDAYADFEFLTIYKALVNFINVDLSAFYLDFAKDVVYIEGAKSLERRQMQTVFYDILVKITKLLTPILPHTAEEIWSYLEFETEDFVQLSELPEVQTFANQEEILDTWAAFMDFRGQAQKALEEARNAKVIGKSLEAHLTVYPNEVVKTLLEAVNSNVAQLLIVSELTIAEGPAPEAALSFEDVAFTVERATGEVCDRCRRIDPTTAERSYQAVICDHCASIVEENFAEAVAEGFEEK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_NITOC
Sequence: MARLTVEDCIDNIDNRFLLVLAAAKRARQLAMGATPTVPWDKDKPTVVALREIAEGHIDVGVMDTASAREHAKESQVSEEEVREES
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: RPC6_YEAST
Sequence: MSGMIENGLQLSDNAKTLHSQMMSKGIGALFTQQELQKQMGIGSLTDLMSIVQELLDKNLIKLVKQNDELKFQGVLESEAQKKATMSAEEALVYSYIEASGREGIWSKTIKARTNLHQHVVLKCLKSLESQRYVKSVKSVKFPTRKIYMLYSLQPSVDITGGPWFTDGELDIEFINSLLTIVWRFISENTFPNGFKNFENGPKKNVFYAPNVKNYSTTQEILEFITAAQVANVELTPSNIRSLCEVLVYDDKLEKVTHDCYRVTLESILQMNQGEGEPEAGNKALEDEEEFSIFNYFKMFPASKHDKEVVYFDEWTI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Involved in recruitment of Pol III to the preinitiation complex.  Involved in the configuration of an initiation-competent form of RNA polymerase.
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC6, RNA polymerase III subunit C6, C34, DNA-directed RNA polymerase III 36 kDa polypeptide.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
What are the subcellular locations of this protein?
Nucleus.
Protein: LEU3_BORA1
Sequence: MTQKIAVLPGDGIGPEIVEQAVRVLQALNLPLELQEAKVGGAAFDAFEHPLPPATLGLAKSSHAVLFGAVGDWKYDSLPREFRPEQAILGLRRALGLFANLRPAILYPELASASSLKPEIVAGLDIIIIRELTGDIYFGTPRGVRSAPDGVFSGEREGYDTMRYAESEVRRIAHVGFETARKRNKKLCSVDKANVLETSQFWRDIVIEVAREYPDVELSHMYVDNAAMQLVRNPRQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLNASGQGLYEPSHGSAPDIAGQGIANPLATILSAAMLLRYSLNQPAQADRIEAAVRKVLAQGLRTADIHEAGTTKVSTSQMGDAVLKALA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT106_YEAST
Sequence: MSKLFLDELPESLSRKIGTVVRVLPSSLEIFEELYKYALNENSNDRSGRHKKPRIDVSSDLLKTDEISETNTIFKLEGVSVLSPLRKKLDLVFYLSNVDGSPVITLLKGNDRELSIYQLNKNIKMASFLPVPEKPNLIYLFMTYTSCEDNKFSEPVVMTLNKENTLNQFKNLGLLDSNVTDFEKCVEYIRKQAILTGFKISNPFVNSTLVDTDAEKINSFHLQCHRGTKEGTLYFLPDHIIFGFKKPILLFDASDIESITYSSITRLTFNASLVTKDGEKYEFSMIDQTEYAKIDDYVKRKQMKDKSMSEELKAKSKSKGQATDGTADQPSILQEATRQMQDEKKAGVFSDDDEENDQNFEAESDLSDGSGQESSDGAEDGEEAEEDDEEDDEEEDKKGQSALNRDNSFASINGQPEQELQYKEFKEPLELEDIPIEIDNDDDEDDEDGSGVEYD
What is the function of this protein?
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing.  Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA.  Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by directly recruiting the SWI/SNF and RSC chromatin remodeling complexes to the histone genes in a cell cycle dependent manner.  In cooperation with HIR and ASF1, creates a repressive structure at the core histone gene promoter and contributes to their repression outside of S phase.  Involved in regulation of Ty1 transposition.
What are the official names of this protein?
Histone chaperone RTT106, Regulator of Ty1 transposition protein 106.
What is the protein family that this protein belongs to?
Belongs to the RTT106 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Localizes to the promoter region of histones HTA1-HTB1, HHT1-HHF1, and HHT2-HHF2,.
Protein: SSRP_ACIB5
Sequence: MAKATVVKKHNGGTIAQNKRARHDYFIEEKFEAGMSLLGWEVKSLRAGRMSLTESYVIFKNGEAFLFGAQIQPLLSASTHIVPEATRTRKLLLSRRELEKLMGAVNQKGYSCVPLACYWKGHLVKLEIALVKGKQLHDKRATEKERDWQRDKARIFHK
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: UPPP1_BACAH
Sequence: MSDIIIAFILGIVEGLAEFLPISSTGHLILVGHLLGFEGERAKTFEIVIQLGAILAIAILYHKRLVSLCNIKPLLRKEKKFNAFHVFLGVFPAVVAGLLLHDVIKTYLFQPYTVVIGLVAGAILMIFAEVKKQEATSYSLDDLTYRQALTIGLFQCLAVYPGFSRAGSTISGGLLAKVNYKTASEFSFLIALPVMVGATGLDLLKSWTYLSVDDIPMFAVGFITSFIVAMLAVVTFLKLLEKIGLKPFAYYRILLAILFTVFVLL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase 1, Bacitracin resistance protein 1, Undecaprenyl pyrophosphate phosphatase 1.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS9_STAAB
Sequence: MTLAQVEYRGTGRRKNSVARVRLVPGEGNITVNNRDVREYLPFESLILDLNQPFDVTETKGNYDVLVNVHGGGFTGQAQAIRHGIARALLEADPEYRGSLKRAGLLTRDPRMKERKKPGLKAARRSPQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RL21_SHELP
Sequence: MYAVFQSGGKQHRVAEGHTVRLEKLEVATGETIEFDQVLLVADGETVHVGAPLVEGGKVVAEVISHGRGEKVTIVKFRRRKHHDKKMGHRQWFTEVKITAINA
What is the function of this protein?
This protein binds to 23S rRNA in the presence of protein L20.
What are the official names of this protein?
50S ribosomal protein L21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL21 family.