PharMolix/UniProtQA huggingface dataset:
Protein: SMCO4_ARGMO
Sequence: MAGRNKAKPRLSKKEKEERRKDMAEVQEKVFSVVVPVVVAFTVVIMLIVYLKTRPRTDF
What are the official names of this protein?
Single-pass membrane and coiled-coil domain-containing protein 4 homolog.
What is the protein family that this protein belongs to?
Belongs to the SMCO4 family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RNC_STRP1
Sequence: MKQLEELLSTSFDIQFNDLTLLETAFTHTSYANEHRLLNVSHNERLEFLGDAVLQLIISEYLFAKYPKKTEGDMSKLRSMIVREESLAGFSRFCSFDAYIKLGKGEEKSGGRRRDTILGDLFEAFLGALLLDKGIDAVRRFLKQVMIPQVEKGNFERVKDYKTCLQEFLQTKGDVAIDYQVISEKGPAHAKQFEVSIVVNGAVLSKGLGKSKKLAEQDAAKNALAQLSEV
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  In this organism endogenous ribonuclease 3 and Cas9 are required for correct coprocessing of pre-crRNA and the trans-encoded small RNA (tracrRNA).  Cas9, crRNA and tracrRNA are required for cleavage of invading DNA (PubMed:21455174, PubMed:24270795).
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCH1_TERTT
Sequence: MKPTPAELYANLISSTGEDLQRPGLQGTPARAATAFEYLTSGYKQSVQEVVNDALFPSDSNDMVVVRDIELFSLCEHHMLPFIGKAHVGYIPTGKVLGLSKVARIIDMYARRLQIQEQLTHQVASTIAEVTGAAGVGVIIEAKHLCMMMRGVEKQNSVMKTSAMLGSFRANLSTRSEFLALLNN
What are the official names of this protein?
GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP-CH-I.
What is the protein family that this protein belongs to?
Belongs to the GTP cyclohydrolase I family.
Protein: PHS_ACIC5
Sequence: MAQLTPKAIEERLSSLPAWKLQAPEIERVVEFSDFVAAMAFVNKVAEKAELAGHHPDIDIRYNRVRLALVTHDAGGLTERDFDLAASIEALL
What are the official names of this protein?
Putative pterin-4-alpha-carbinolamine dehydratase, PHS, 4-alpha-hydroxy-tetrahydropterin dehydratase, Pterin carbinolamine dehydratase, PCD.
What is the protein family that this protein belongs to?
Belongs to the pterin-4-alpha-carbinolamine dehydratase family.
Protein: THIE_ALBFT
Sequence: MVGASTLAHDVRLQALRLYLVTDQFCAGGRTLADVVAAAVQGGVTCVQLREKQLNTRDFLAQALALKDLLAPHGIPLVINDRIDVALACGAQGVHLGQSDMPVTQARRLLPPEVFIGWSVETLEDVARSAELPVDYLGVSPIFATPTKTDTLPPWGLEGLRQVRRATTVPLVAIGGIHVGNAREVLLAGADGLAVVSALCAAQDPCVAALRLRQLIDAV
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: MTNC_PROMM
Sequence: MITHILLDIEGTTCPTSFVSDTLFPYADTHLEGFLNEHIENNEVQSLIDEAWHEWQADEDPSSKDLLSKAFRENSSEIENICSYLHHLITIDRKSSALKDLQGRIWREGYEKGDISSSLYPETIEVLNKLKQQDYILAVYSSGSISAQKLLYRHTTNGDQTALFSHWFDTRTGNKKESKSYSDISIAMNIPVEKVMFVSDSCAECNAAKKAGMSVLFSLREGNPEQDPHDHQPIKDLRCLFDYLL
What is the function of this protein?
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
What are the official names of this protein?
Enolase-phosphatase E1, 2,3-diketo-5-methylthio-1-phosphopentane phosphatase.
What is the protein family that this protein belongs to?
Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
Protein: KTHY_HALOH
Sequence: MRGLFITLEGIEGSGKSTQIEMLYKRLKKDGFDVIITREPGGTPIGKEIRKLLLDPDNIMGAKAEFLLYAADRAQHVVELIKPALESGKVVLADRFIDSSIAYQGYGRGLDIDVVKTVNEWVIDGCWPDLTFVLDLDVEKGLERARGYSPDNQGDRLERELVTFHRRVRQAYHQLAEDRRFIMLDADRSREEIHREIYHKVKGCLIK
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: HEM3_CUTAK
Sequence: MSAIRLGTRASTLATTQSEMVAGLLRSEGLDVNLTTITTHGDTSTASLAAMGGIGVFASAIRAALLEGEADIAVHSFKDLPTGRPLGLAIGAVPARADPRDALVARDGLTLHDLPQEASVGTGSPRRAAQLLAVRPDLTIVDIRGNVDTRLGRVKGLGRYAKNGGKEDLDAVVLAASGLARLGHSGAVTEFLDPSVVLPAPAQGALAVECRTADSRHGKLAKALARIDDRRTRLAATAERAVLSHLEAGCAAPIGALAQLKPVSGKSLQVLTLDVVVAAVDGSRTVREQVSVELPAEVEPALAAAHTLGVTAAEELLDDGAADVADLKASGSTR
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: LEUD_BRUSU
Sequence: MDKFTKLTGVAAPLPIVNIDTDMIIPKDYLKTIKRTGLGKGLFAEMRFNEDGSENPDFVLNKPGYRKAQILVAGDNFGCGSSREHAPWALLDYGIRCVISTSFADIFYNNCFKNGILPIKVAQEDLDKLMDDASRGANATLTIDLETKQIHGPDGGTISFDLDDFKRHCLLNGLDDIGLTMEKAKSIDTFEAKNAEERPWA
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: RIMP_ECOK1
Sequence: MGLSTLEQKLTEMITAPVEALGFELVGIEFIRGRTSTLRIYIDSEDGINVDDCADVSHQVSAVLDVEDPITVAYNLEVSSPGLDRPLFTAEHYARFVGEEVTLVLRMAVQNRRKWQGVIKAVDGEMITVTVEGKDEVFALSNIQKANLVPHF
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAG15_MOUSE
Sequence: MDRHLCTCRETQLRSGLLLPLFLLMMLADLTLPAQRHPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKKTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRATQFPDGVDVRVPGFGETFSMEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQMYGGPVVLVAHSMGNVYMLYFLQRQPQVWKDKYIHAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTWSHEKVFVYTPTTNYTLRDYHRFFRDIGFEDGWFMRQDTEGLVEAMTPPGVELHCLYGTGVPTPNSFYYESFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHRVSLQELPGSEHIEMLANATTLAYLKRVLLEP
What is the function of this protein?
Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:16837646, PubMed:17626977, PubMed:11790796, PubMed:16106046, PubMed:16880524, PubMed:19017977, PubMed:20410020).  Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity).  Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:20410020).  Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (PubMed:16837646, PubMed:17626977).  Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:16837646, PubMed:17626977).  Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:27993948).  Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (PubMed:16880524, PubMed:19017977).  At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity).
What are the official names of this protein?
Phospholipase A2 group XV, 1-O-acylceramide synthase, ACS, LCAT-like lysophospholipase, LLPL, Lysophospholipase 3, Lysosomal phospholipase A and acyltransferase, Lysosomal phospholipase A2, LPLA2.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
What are the subcellular locations of this protein?
Secreted. Lysosome. Membrane; Peripheral membrane protein.
Protein: E2AK1_RAT
Sequence: MLGGGSVDGERDTDDDAAGAVAAPPAIDFPAEVSDPKYDESDVPAELQVFKEPLQQPTFPFLVANQLLLVSLLEHLSHVHEPNPLHSKQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCQDNSYMQKIRSREIALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVLQPQDRVPIQLPSLEVLSEHEGDRNQGGVKDNESSSSIIFAELTPEKENPLAESDVKNENNNLVSYRANLVIRSSSESESSIELQEDGLNESPLRPVVKHQLPLGHSSDVEGNFTSTDESSEDNLNLLGQTEARYHLMLHIQMQLCELSLWDWIAERNNRSRECVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACADIIQKSADWTNRNGKGTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNAAQRPSALQLLQSELFQTTGNVNLTLQMKIMEQEKEIEELKKQLSLLSQDKGLKR
What is the function of this protein?
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions.  Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock.  EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming.  Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity.  This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR.  Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions.  In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties.  It thereby plays an essential protective role for RBC survival in anemias of iron deficiency.  Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity).
What are the official names of this protein?
Eukaryotic translation initiation factor 2-alpha kinase 1, Heme-controlled repressor, HCR, Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase, Heme-regulated inhibitor, Hemin-sensitive initiation factor 2-alpha kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: BRX1_XENLA
Sequence: MSAYKRKRGSLPEVATNTKKAKKQLAGSEQEATAGEEFIVPPPVSEGKWKNKERVLIFSSRGINFRTRHLMQDLRSLMPHSRAETKMDRKDKLFVVNEVCEMKNCNKCIYFEAKKKQDLYMWLSNSPEGPSAKFLVQNIHTLAELKMSGNCLKGSRPILSFDPAFDREPQYALLKELLTQIFGTPRYHPRSQPFVDHIFTFSIADNRIWFRNYQIIEEDAALVEIGPRFVLNLIKIFKGSFGGPTLYENPHYQSPNMHRRMIRLATAAKVKEKQQVKEVQKLKKEEDRPVIPVDPTEAVFYTPAEEKPQVIETEPPAPKPKMKRKDKQFKRQRMAKKRM
What is the function of this protein?
Required for biogenesis of the 60S ribosomal subunit.
What are the official names of this protein?
Ribosome biogenesis protein BRX1 homolog, Brix domain-containing protein 2, Bx24.
What is the protein family that this protein belongs to?
Belongs to the BRX1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: NU4LC_LEPVR
Sequence: MILEHVLVLSAYLFLIGLYGLITSRNMVRALMCLELILNAVNMNFVTFSDFFDNSQLKGDIFCIFVIAIAAAEAAIGLAIVSSIYRNRKSTRINQSTLLNK
What is the function of this protein?
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic, NAD(P)H dehydrogenase subunit 4L, NADH-plastoquinone oxidoreductase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: SH3L1_PONAB
Sequence: MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
What is the function of this protein?
Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs.  May function as a ubiquitin ligase-substrate adapter.  Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs.
What are the official names of this protein?
Adapter SH3BGRL, SH3 domain-binding glutamic acid-rich-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SH3BGR family.
Protein: YCCT_ESCF3
Sequence: MKAGTLTLLIALCLPISVSATTLRLSSEVDLLVLDGKKVSSSLLRGADSIELENGPHQLVFRVEKTIQMPGHGERLYISPPLVASFNTQLISQVNFRLPSLLNEQETAHFDAAPRLELLDGDAMPIPVKLDILAITSVAKPIDYEGEVERYNKSAKRASLPQFATMMADDSTLLSGVSELDAIPPQSQVLTEQRLKYWFKQADPQTRNNFLQWAEKQPSS
What are the official names of this protein?
UPF0319 protein YccT.
What is the protein family that this protein belongs to?
Belongs to the UPF0319 family.
Protein: RS2_CHLAA
Sequence: MTQALPRVVTIRELLEAGAHFGHPTNRWNPKMKPYIFTARNGIHIIDLQKTVTGLSRAYQFITELTARGEKVLFVGTKKQAQEAVMEEAVRSGQFYINQRWLGGTLTNFATIKRRLKLLSDLEEQRDRGDFARLTKAEAAKLEEKIVRLNRVFAGLKGMDRLPGAVFIIDPRKEELAVREAVKEGIPIVAMVDTNCDPDPIDYVIPCNDDAIRGIRLMAGKIADAAIEGTRRREMSQE
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: CO1A2_BOVIN
Sequence: MLSFVDTRTLLLLAVTSCLATCQSLQEATARKGPSGDRGPRGERGPPGPPGRDGDDGIPGPPGPPGPPGPPGLGGNFAAQFDAKGGGPGPMGLMGPRGPPGASGAPGPQGFQGPPGEPGEPGQTGPAGARGPPGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGELGPVGNPGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLPGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGAVGQPGPPGPSGEEGKRGSTGEIGPAGPPGPPGLRGNPGSRGLPGADGRAGVMGPAGSRGATGPAGVRGPNGDSGRPGEPGLMGPRGFPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPSGDPGKAGEKGHAGLAGARGAPGPDGNNGAQGPPGLQGVQGGKGEQGPAGPPGFQGLPGPAGTAGEAGKPGERGIPGEFGLPGPAGARGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAPGTAGPSGPSGLPGERGAAGIPGGKGEKGETGLRGDIGSPGRDGARGAPGAIGAPGPAGANGDRGEAGPAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGTKGPKGENGPVGPTGPVGAAGPSGPNGPPGPAGSRGDGGPPGATGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRSGETGASGPPGFVGEKGPSGEPGTAGPPGTPGPQGLLGAPGFLGLPGSRGERGLPGVAGSVGEPGPLGIAGPPGARGPPGNVGNPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNAGPVGAAGAPGPQGPVGPVGKHGNRGEPGPAGAVGPAGAVGPRGPSGPQGIRGDKGEPGDKGPRGLPGLKGHNGLQGLPGLAGHHGDQGAPGAVGPAGPRGPAGPSGPAGKDGRIGQPGAVGPAGIRGSQGSQGPAGPPGPPGPPGPPGPSGGGYEFGFDGDFYRADQPRSPTSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPEDIPVKNWYRNSKAKKHVWVGETINGGTQFEYNVEGVTTKEMATQLAFMRLLANHASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWQKTIIEYKTNKPSRLPILDIAPLDIGGADQEIRLNIGPVCFK
What is the function of this protein?
Type I collagen is a member of group I collagen (fibrillar forming collagen).
What are the official names of this protein?
Collagen alpha-2(I) chain, Alpha-2 type I collagen.
What is the protein family that this protein belongs to?
Belongs to the fibrillar collagen family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: TPMT_ALIFM
Sequence: MEHEFWQKKWASNVIGFHLPDTNPILTQYWSALEPKRNETVFVPLCGKSMDLDWLAERHHSVTGVELSQIAVRAFFAERLYTPTVTQLSSTLELYEFDEFTIYSGDYFVAPIEAADLIYDRAALVALPKEMREEYTQVLRSRLKEGGRILLVTLDYDQNEMAGPPFSVPEEEVRALFSGMKITRLQRDEADAEHPKIKKGLSRFAEEVWLIEN
What are the official names of this protein?
Thiopurine S-methyltransferase, Thiopurine methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KPYM_HUMAN
Sequence: MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
What is the function of this protein?
Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth (PubMed:18337823).  In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity (PubMed:20847263).
What are the official names of this protein?
Pyruvate kinase PKM, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Threonine-protein kinase PKM2, Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, Tyrosine-protein kinase PKM2, p58.
What is the protein family that this protein belongs to?
Belongs to the pyruvate kinase family.
What are the subcellular locations of this protein?
[Isoform M2]: Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to various signals, such as EGF receptor activation or apoptotic stimuli (PubMed:17308100, PubMed:22056988, PubMed:24120661). Nuclear translocation is promoted by acetylation by EP300 (PubMed:24120661). Deacetylation by SIRT6 promotes its nuclear export in a process dependent of XPO4, thereby suppressing its ability to activate transcription and promote tumorigenesis (PubMed:26787900). SUBCELLULAR LOCATION: [Isoform M1]: Cytoplasm.
Protein: GLCV_SACS2
Sequence: MVRIIVKNVSKVFKKGKVVALDNVNINIENGERFGILGPSGAGKTTFMRIIAGLDVPSTGELYFDDRLVASNGKLIVPPEDRKIGMVFQTWALYPNLTAFENIAFPLTNMKMSKEEIRKRVEEVAKILDIHHVLNHFPRELSGGQQQRVALARALVKDPSLLLLDEPFSNLDARMRDSARALVKEVQSRLGVTLLVVSHDPADIFAIADRVGVLVKGKLVQVGKPEDLYDNPVSIQVASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEKN
What is the function of this protein?
Part of the ABC transporter complex GlcSTUV involved in glucose uptake (Probable).  Responsible for energy coupling to the transport system (PubMed:12823973, PubMed:14607117).  In vitro, as a free subunit, exhibits a constitutive ATPase activity (PubMed:11807278).
What are the official names of this protein?
Glucose import ATP-binding protein GlcV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: MSC1_SCHPO
Sequence: MRKNSSHENQSSENIIEFPYVDFEELNVHSNIFSELEHAKPSTQQQQQQQNISNETTSTGPRICISRDEFKAVNLLTKEEINVRVTPKKEEFSRGLDFISDLYDQTARKSGAVRVIPPDNWKCPLTINTTTFKFLTRKNNPSSMSLVSNYPLDAISSQQKFHGNDKTLEKNSAKATINKSNSTAETSSTATVEPYDSNDLYRIFDRPDAVVLSYIFVLGKAVDLLQIKQWLQLSKQKNLLEFEFWSQAAQHYKLDVNSLRNAYNLYAETGVTTRTGNDGGSPINRPAKRVKRQNHIPKCKLCAQEGSSLVTCCICQSNYHYACVEAPFAPFSDIHYWTCNSCIPSSLKILWKEVDYHCISSFLQSSNELASSLKKQLPSFLAQTPLTLPSNTKTPPASARQSSRRTRSTSGKGFETKISINLDSDIKLLNTLSPLETFFWCCSFPSTASTSSPFSYYPESLPTPLLGRAVNTTAFPTSRQNAYYNDPWNLYFIHFSKLSPLRFTPPGILTSTISLGQPLTCQGWQRDSMSLFGMHYHHYGAQRIWYVIPEVDGPKYEKLLNDLSPSFIQEKPETLIKSKILLPISMLISNGIQVLTFVQNSNEFVITSPNTYYTVLDTGFSLSESVPFATKEWIQDMHAENSFNMYKNLHISAPFSLDHILLANATLDKTVHSAYWLMTCLKDRVDRELTLRNEFRKRHPLLTWIPTPLESSVMACAFCKTFAYLASIEEKNGTKTACLSHKDECFPNTDSDLTVLVRYDDNALLAAYSKVVERAHKADTWLENYKEALGSDNSRPSLKVLKTLLNEAETICCPLQEVSLVRNLVKTAQQWLDKFAIIFKKKSMVKKEKRKPKRGSATHSHLESPSEEVEDLNSSNINEADLLINLVEEAEQFTFDFPEMAVAFEKAESLKIFREKANAMKERSLSYEECLAIVEEGESLQLKTPELLYFKQYMEKTEWIDSFNQISQKTDSTMEELVELIERGEKIGLTSDNENMATALLLKEKSENWMKQVEGLLSQETLSTSKLFQLKSEANSICINRGLLEQLNEVLQKSENFHTQLVSLISRARDPDYYSRPTIEEAKTVLAESENLTNKPEEYTVAQKLLTQTYEWVRRGKRLFGKANAPLEIFNQHLEFVEQRNTNAMVDEGSDAPFHVGNEYYVIAGSDPSDFHYCFCRQPEAGMMIECELCHEWYHAKCMKMSKKKLRADEKFICPICDYRVEVPRHSHRPPLIELQKMVDDIPTLPFQPIEIELLKRVVKQAEEFKNKMQSEVCDPTQLSEKDVPLLQFYLRKLEGSEILFTEELNVFRQKLHEFMPVAPQPPPFIGESRSNRKPRPTKRQREIMEQVESGKLTSAEGAAAIAATQTRNQNNFISKPFNVHTLSTTLSPWAMKSLAQAAISPNPMPSAHDLLPTSNPAELFTNISPEIKELSVDSTSTLGGLNSSHLVSDQNASVICLCRQPFAISDGTVQCHNCLEWFHYECVGLSSDIVSTLSNYACPDCCSKEGKLYPWNTRPRSTPSVWLSQAYSPSVLQGTTENVAFLNKAFSASANLFDVLPVSNTPSHFSKMDYVLEDRKPDLFTETYLSM
What is the function of this protein?
Has a role in regulating chromatin structure via global deacetylation of histone H3.  This function is associated with the activity of a histone deacetylase.
What are the official names of this protein?
Multicopy suppressor of chk1 protein 1.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with chromatin.
Protein: PURT_MYCVP
Sequence: MTTIGTPLSPRATKVMLLGSGELGREVLIALQRLGVETIAVDRYDNAPGQQVAHHARTIAMTDPDQLRALIEAERPDLVVPEIEAIATPALEALEAEGVTTVIPTARAARLTMDREGIRRLAAETLGLPTSPYRFCDSLEELTAAIEGGIGYPCVVKPVMSSSGKGQSKIDGPEGVAAAWEYAMSGSRVSNTRIIVEGFVDFDYEITLLTVRARGADGEIETRFCEPIGHRQVSGDYVESWQPHPMPGTALERARQIAGAVTRDLGGQGIFGVELFVKGDQVWFSEVSPRPHDTGMVTMVTQWQNEFELHARAILGLPVDTTLKSPGASAVIYGGVDAEGVVFDGVDLALRVPHTDIRLFGKPESFVNRRMGVALAFADDVDTARRNAAEAAGRVTPRAV
What is the function of this protein?
Involved in the de novo purine biosynthesis.  Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR).  Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
What are the official names of this protein?
Formate-dependent phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase 2, Formate-dependent GAR transformylase, GAR transformylase 2, GART 2, Non-folate glycinamide ribonucleotide transformylase, Phosphoribosylglycinamide formyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the PurK/PurT family.
Protein: Y9263_DICDI
Sequence: MELLIPLSLLGLYLFSGTRDSVHKGEVKDDLKEKPIKVNFNLTDSTKVDHKTHLKQYSSLKPGDTLEIL
What are the official names of this protein?
Putative uncharacterized protein DDB_G0277463.
What are the subcellular locations of this protein?
Secreted.