PharMolix/UniProtQA huggingface dataset:
Protein: SLIK1_MOUSE
Sequence: MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNGQDEHATPGAVPNGGTKIPGNWQLKIKPTPPIATGSARNKPPVHGLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIANIENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFRKDFMLLSNEEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGLLLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADGSHRVYDCGSHSLSD
What is the function of this protein?
It is involved in synaptogenesis and promotes excitatory synapse differentiation (By similarity).  Enhances neuronal dendrite outgrowth (PubMed:14550773).
What are the official names of this protein?
SLIT and NTRK-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the SLITRK family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Secreted. Synapse.
Protein: APAG_WOLWR
Sequence: MIEYTLTTNFVEVTVLPIYIEEQSIPYENCYVWMYNVKIKNKSQSTIQLLSRHWQIIDYKGKVNEIAGVGVIGEQPVIKSGEVFKYTSGTYLNVPSGIMQGKYEFLNEESIKVFEVMIPPFSLDSPYIKTRPH
What are the official names of this protein?
Protein ApaG.
Protein: FAEB1_ASPOR
Sequence: MLVMQLLLPFLASTAAAAAAIDSTSSSNGSDHHGSSFQAECESFKAKINVTNANVHSVTYVPAGVNISMADNPSICGGDEDPITSTFAFCRIALNVTTSSKSQIFMEAWLPSNYSGRFLSTGNGGLGGCVKYDDMAYAAGYGFATVGTNNGHFGNNGVSFYQNTEVVEDFAYRALHTGVVVGKELTKNFYPQGYNKSYYLGCSTGGRQGWKSVQTFPDDFDGVVAGAPAFNFINLTSWGARFLTLTGDSSAETFVTETQWTAVHNEIIRQCDSLDGAKDGIIEDPDLCQPIIEALLCNATQSSTSGTCLTGAQVKTVNGVFSATYGLNGSFLYPRMQPGSELAAYSSYYSGTPFAYAEDWYRYVVFNNTNWDVATWTVQDAAIANAQDPYQISTWNGDLSPFQKKGGKVLHYHGMEDAIISSESSKVYYKHVADTMNLSPSELDSFYRFFPISGMAHCANADGPSAIGQGTGTFAGNNPQDNVLLAMVQWVEEGVAPDFVRGAKLNGSTVEYRRKHCKYPKRNRYVGPGSYTDENAWECV
What is the function of this protein?
Involved in degradation of plant cell walls.  Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin.
What are the official names of this protein?
Probable feruloyl esterase B-1, Ferulic acid esterase B-1, FAEB-1.
What is the protein family that this protein belongs to?
Belongs to the tannase family.
What are the subcellular locations of this protein?
Secreted.
Protein: TSAD_RHORT
Sequence: MSMPFRVLGIETSCDETAAAVVEPAADGRGGRIMAEALLSQVEEHRPYGGVVPEIAARSHLDHVDSLVIRALGEAGLTVHDIDAVAATGGPGLIGGVIVGVMTAKAIAQVAGKPFIAVNHLEGHALTVRMTAGIDFPYLLLLASGGHCQLLAVEGVGRAKRLGTTIDDAAGEAFDKVAKMLGLGYPGGPAVERAARRGDPRRFRLPRPLLDRPGCDLSFSGLKTAVRQTVEKLPPGPLSEGDIADLCASFQAAVADCLADRCRVAAGIFSARHGRGRPLVVAGGVAANASLRAALTEVARQADMTFVAPPLALCTDNAAMIAWVGVERLRLGLVDTMDFKPRPRWPLDPDAPKAAGAGGVKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF1_DESVV
Sequence: MFAKLENLELKFEDLEQQLSSAEVFNDQDRYRKLTKAHADLKQVVDAFRRYKEMKQNLADNKELLGDSDHEIRAMAHEEIKAIEAALPDIEQELKILLLPRDPMDDKNILLEIRAGTGGEEASLFAADLFRMYTRYAEIMGWKVEVLSASDSDTGGYKEIIALIAGDKVYSRLKYESGTHRVQRVPATEAQGRIHTSAATVAVMPEAEEVDVDIRPDDLRIDVYRASGAGGQHVNKTESAVRITHLPTGIVVACQDEKSQHKNKAKAMKVLISRVLQAEQERAHSVIADARRALVGSGDRSERIRTYNYPQSRITDHRINLTLYSLDKVMEGELAPLVDALVTHAQTEALKAQADAS
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GP46_BPSP1
Sequence: MMTEDQKFKYLTKIEELEAGCFSDWTKEDITGDLKYLKKGIIEESIELIRAVNGLTYSEELHDFTQEIIEELDISPL
What is the function of this protein?
Acts as a host growth inhibitor by inhibiting DNA-binding of microbial histone-like protein HU, thereby preventing chromosome segregation and causing filamentous cell morphology and growth defects in the host.
What are the official names of this protein?
Inhibitor of histone-like protein HU, Gene 46 protein, Gp46, Gene product 46.
Protein: CYB_TAMRF
Sequence: MTNIRKTHPLIKIINHSFIDLPAPSNISAWWNFGSLLGICLIIQILTGLFLAMHYTSDTMTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTYFETWNIGVILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVMVHLLFLHETGSNNPSGLISDSDKIPFHPYYTIKDILGILLLVLALMTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILMLFPVLHMSKQRSMMFRPLSQCMFWILVADLFTLTWIGGQPVEYPFIIIGQLASILYFMIILLILPTISLFENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: MAT2B_DANRE
Sequence: MPGFNYGGDQDEVYTPYRRVLVTGATGLLGRAVYKEFKNNDWDALGCGYNRARPFFLKCNLLDEDAVRGVIQSFQPHVIVHCAAERRPDVVERHTEAAMNLNVHACATLAKEAGGSFLIYISTDYVFDGRNPPYGENDAPNPLNLYGKSKLEGEREILRHCPGAAVLRVPILFGEVEKVEESAVTVLFERVQEGAESCTIDHCQQRFPTYTNDVARVCRNMAERALQDQSLRGIFHYSAKEQMTKYEMTCAIADAFNLPSSHLIPMTEQPAGAGAQRPQNAQLECSRLELLGLSVESTPFKNAIRDSLWPFQHDKRWRQTVFH
What is the function of this protein?
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP.  Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.  Can bind NADP (in vitro).
What are the official names of this protein?
Methionine adenosyltransferase 2 subunit beta, Methionine adenosyltransferase II beta, MAT II beta.
What is the protein family that this protein belongs to?
Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
Protein: RS4_METM6
Sequence: MGDPRRLGKKYDTPNHPWIGERIQKEREISQKYGLVNKKELWKMETQLRNYRRQARKLISDTTTQGGKEAVQLFNVLKRYAILVEQEPTLDHVLSLDIESILERRLQTIVYRKGLAKTAKQARQFIVHGHIAVNGKRVTAPAYLVSVAENDAIEYVPNSPMASENHPERTAAVSEENQ
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: PUB33_ARATH
Sequence: MALVSPIPAMGERAGSMRFHGIGSPGSRSSRSGIMDEPVSRLIDEKIFVAVDKHVAKSKSTLIWALQNTGGKKICLIHVHQPSQMIPLMGAKFPVGAVKEEEVRVFREKEREKVHMILDDYLRICQQRGVRAEKMFIEMESIENGIVQLISELGIRKLVMGAAADRHYSRRMTDLKSRKAIFVRREAPTLCQIWFTCKGYLIHTREATMDDTESEYASPRPSISASDLLQTFSTPESEHQHISRVQSTDSVQQLVSNGSSTEQSGRVSDGSLNTDEEERESDGSEVTGSATVMSSGHSSPSSFPDGVDDSFNVKIRKATSEAHSSKQEAFAETLRRQKAEKNALDAIRRAKQSESAYSEELKRRKDTEIAVAKEKERFITIKNEQEVIMEELQSAMAQKAMLESQIAKSDGTMEKLNQKLDIAVKLLQKLRDEREELQTERDRALREAEELRSHAETSTLQLPQYFTDFSFSEIEEATNHFDSTLKIGEGGYGSIYVGLLRHTQVAIKMLNPNSSQGPVEYQQEVDVLSKMRHPNIITLIGACPEGWSLVYEYLPGGSLEDRLTCKDNSPPLSWQNRVRIATEICAALVFLHSNKAHSLVHGDLKPANILLDSNLVSKLSDFGTCSLLHPNGSKSVRTDVTGTVAYLDPEASSSGELTPKSDVYSFGIILLRLLTGRPALRISNEVKYALDNGTLNDLLDPLAGDWPFVQAEQLARLALRCCETVSENRPDLGTEVWRVLEPMRASSGGSSSFHLGRNEHRIAPPYFICPIFQEVMQDPHVAADGFTYEAEAIRAWLDSEHDTSPMTNVKLSHTSLIANHALRSAIQEWLQHHL
What is the function of this protein?
Functions as an E3 ubiquitin ligase.
What are the official names of this protein?
U-box domain-containing protein 33, Plant U-box protein 33.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Protein: H31_RAT
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H3.1.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: MYCC_MYCTT
Sequence: MAIDEQIPRVQRALIQSSTPGVLQFTETREVPKLLPDQVLVRVVAVALNPCDWKMPTNFPCPGAGVGADFSGTVVRVGDDVRPGKFDVKLGDRVAGAVHASNRLKPQDGTFAEYIAVRADALWRIPDGMDFHVAAAIGLCVVGTVGLAAFHERHLNLPGSPEQPVKPRAGGQPPWVLVYGGSTASGTMAIQILKLAGFRVVTTCSPANFALVESYGADKAFDYHSPNLGESIRAYTNNSLSFVMDIIASANSLRQCYASIGRAGGHYVGFELVPDELAGIRKAVRASWVLGIRLLGYEIALDRGYGSPPDPELGMWGRAWFKRTEDLVWGGKIRPHPIELDTESGFDGIVAGVERLKRGEVSGKKLVYLIR
What is the function of this protein?
Trans-enoyl reductase; part of the gene cluster that mediates the biosynthesis of myceliothermophins, mycotoxins that contain a trans-fused decalin ring system connected to a conjugated 3-pyrrolin-2-one moiety and that have potential anti-tumor properties (PubMed:27960349).  The polyketide synthase module (PKS) of the PKS-NRPS mycA is responsible for the synthesis of the octaketide backbone (PubMed:27960349).  The downstream nonribosomal peptide synthetase (NRPS) module then amidates the carboxyl end of the octaketide with a leucine (PubMed:27960349).  A reductase-like domain (R) at the C-terminus catalyzes the reductive release of the polyketide-amino acid intermediate (PubMed:27960349).  Because mycA lacks a designated enoylreductase (ER) domain, the required activity is provided the enoyl reductase mycC (PubMed:27960349).  Following mycA-catalyzed construction and release of aminoacyl polyketide aldehyde, Knoevenagel condensation yields the expected ketone (PubMed:27960349).  This C18 keto acyclic precursor is the substrate of the Diels-Alderase mycB, that catalyzes the Diels-Alder cycloaddition to produce myceliothermophin E (PubMed:27960349).  A yet unknown oxygenase involved in the production of myceliothermophin A, via substitution with a hydroxyl group at the C21, has still to be identified (PubMed:27960349).
What are the official names of this protein?
Trans-enoyl reductase mycC, Myceliothermophin biosynthesis cluster protein C.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family.
Protein: OBG_CLONN
Sequence: MFIDTAKILVKSGNGGNGCISFRREKYVAMGGPNGGDGGNGGSVILVADRNLTTLLDFTYRRKYVADNGEDGGNSKCFGKKGEDLYIKVPIGTVVKDVETGKTMVDLAKEGDSYIVARGGKGGKGNYHFATPTRQAPNFAEPGMPGEERMINLEIKLLADVGLIGFPNVGKSTLLSMVSKAKPKIANYHFTTLKPNLGVVKIEGANAFVMADIPGIIEGASEGVGLGLDFLRHIERTRLLVHVVDISGVEGRNPIEDFKKINEELKNYSVKLWDRPQIVVANKIDMLYDEEVFETFKKEVNKLGFDKVFKISAATRDGVDDLIKEVTRQLSMIPITEMEIPEEERFMPEEKRFTYTIRVEDGVYVVEGSFVDRLLKSVNVNDPDSLRYFHKVLRNKGILDELKEMGIQDEDTVRLNDFEFDFLL
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HMGCL_PSEMV
Sequence: MQAVKVFEVGPRDGLQNERQPLSVAARVGLIGELAGTGLRHIEAGAFVSPRWVPQMAGSDEVLRQLPSNDGVSYTALVPNRQGFEAAQRAGCREVAVFAAASEAFSRNNINCSIDESFERFTPVLRAANEASIRVRGYVSCVLGCPFSGAVAPEAVAKVARRLYELGCYEISLGDTIGAGRPDETAQLFELCARQLPVAALAGHFHDTWGMAIANVHAALAQGVRTFDSSVAGLGGCPYSPGASGNVATEDLLYLLHGLGYSTGVDLEAVAQVGVRISAQLGTANRSRAGLALAARSAREH
What is the function of this protein?
Involved in the catabolism of branched amino acids such as leucine.
What are the official names of this protein?
Hydroxymethylglutaryl-CoA lyase, HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA lyase family.
Protein: ARGB_MYCBT
Sequence: MSRIEALPTHIKAQVLAEALPWLKQLHGKVVVVKYGGNAMTDDTLRRAFAADMAFLRNCGIHPVVVHGGGPQITAMLRRLGIEGDFKGGFRVTTPEVLDVARMVLFGQVGRELVNLINAHGPYAVGITGEDAQLFTAVRRSVTVDGVATDIGLVGDVDQVNTAAMLDLVAAGRIPVVSTLAPDADGVVHNINADTAAAAVAEALGAEKLLMLTDIDGLYTRWPDRDSLVSEIDTGTLAQLLPTLESGMVPKVEACLRAVIGGVPSAHIIDGRVTHCVLVELFTDAGTGTKVVRG
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL24_STRMK
Sequence: MANRIKKGDQVVVNAGKDKGKQGEVVRVDGDRVVVANVNIVKRHTKPNPQAGVAGGVVEREASIHISNVNVLNPASGKGERVGFKVLEDGRKLRVFRSSGEALDA
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: MYBF_ARATH
Sequence: MGRCGRSNDGVIGGVRPYVRSPVPRLRWTPELHRSFVHAVDLLGGQYKATPKLVLKIMDVKGLTISHVKSHLQMYRGSRITLLGKPEESSSPSSRRRRRQDNEEDHLHDNLSVHARNDCLLGFHSFNFREQTSATDNDDDDFLNIMNMERTKTFAGNGESIKFQSHHSLEAENTKNIWKNTWRENEHEEEEELSLSLSLNHPHNHQQRWKSNASSSLSETSEAVSSSSGPFIFRDCFASSKIDLNLNLSFSLLHS
What is the function of this protein?
Putative transcription factor.
What are the official names of this protein?
Putative Myb family transcription factor At1g14600.
What are the subcellular locations of this protein?
Nucleus.
Protein: GHRA_SALCH
Sequence: MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAVFVLGAGVDAILSKLNAHPEMLDASIPLFRLEDTGMGLQMQEYAVSQVLHWFRRFDDYQALKNQALWKPLPEYTREEFSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGVESYVGREELRAFLNQTRVLINLLPNTTQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAALDSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQVDRARGY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
What are the official names of this protein?
Glyoxylate/hydroxypyruvate reductase A, 2-ketoacid reductase.
What is the protein family that this protein belongs to?
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_RHIMO
Sequence: MTNIRKSHPLFKIINDSFIDLPAPSSISSWWNFGSLLGVCLAVQILTGLFLAMHYTPDTATAFYSVTHICRDVNYGWVLRYLHANGASMFFICLFLHVGRGIYYGSYTFSETWNIGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTTLVEWVWGGFSVDKATLTRFFALHFLLPFIISAMVMVHLLFLHETGSNNPTGIPSDVDMIPFHPYYTIKDILGLVLMLMALLSLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVVALVLSILVLAVIPLLHTSKQRSMTFRPLSQCLFWLLVADLLTLTWIGGQPVEHPFIIIGQLASILYFLIILVLMPLASIAENHLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: AOSL_PLEHO
Sequence: MTWKNFGFEIFGEKYGQEELEKRIKDEHTPPPDSPVFGGLKLKLKKEKFKTLFTLGTTLKGFRRATHTVGTGGIGEITIVNDPKFPEHEFFTAGRTFPARLRHANLKYPDDAGADARSFSIKFADSDSDGPLDIVMNTGEANIFWNSPSLEDFVPVEEGDAAEEYVYKNPYYYYNLVEALRRAPDTFAHLYYYSQVTMPFKAKDGKVRYCRYRALPGDVDIKEEDESGRLTEEEQRKIWIFSRHENEKRPDDYLRKEYVERLQKGPVNYRLQIQIHEASPDDTATIFHAGILWDKETHPWFDLAKVSIKTPLSPDVLEKTAFNIANQPASLGLLEAKSPEDYNSIGELRVAVYTWVQHLRKLKIGSLVPAGQNAIYNVEVETGDREHAGTDATITIRITGAKGRTDYLKLDKWFHNDFEAGSKEQYTVQGFDVGDIQLIELHSDGGGYWSGDPDWFVNRVIIISSTQDRVYSFPCFRWVIKDMVLFPGEATLPFNEVPAIVSEQRQKELEQRKLTYQWDYVSDDMPGNIKAKTHDDLPRDVQFTDEKSRSYQESRKAALVNLGIGSLFTMFENWDSYDDYHILYRNWILGGTPNMADRWHEDRWFGYQFLNGANPVILTRCDALPSNFPVTNEHVNASLDRGKNLDEEIKDGHIYIVDFKVLVGAKSYGGPVLEDIGYKVPDHLKHDEADIRYCAAPLALFYVNKLGHLMPIAIQINQEPGPENPIWTPHEENEHDWMMAKFWLGVAESNFHQLNTHLLRTHLTTESFALSTWRNLASAHPVFKLLQPHIYGVLAIDTIGRKELIGSGGIVDQSLSLGGGGHVTFMEKCFKEVNLQDYHLPNALKKRGVDDPSKLPGFYYRDDGLALWEAIETFIGEIIAIFYKNDDDVKRDNEIQSWIYDVHKNGWRVNPGHQDHGVPASFESREQLKEVLTSLVFTFSCQHAAVNFSQKDHYGFTPNAPAVLRHPPPKKKGEATLQSILSTLPSKSQAAKAIATVYILTKFSEDERYLGNYSATAWEDKDALDAINRFQDKLEDISKKIKQRNENLEVPYIYLLPERIPNGTAI
What is the function of this protein?
Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction; first the lipoxygenase reaction that converts polyunsaturated fatty acids such as arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) into a (8R)-hydroperoxide intermediate ((8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate) followed by the allene oxide synthase reaction that converts the hydroperoxide intermediate ((8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate) into the allene oxide (8,9-epoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate) (PubMed:9302294, PubMed:10559269).  Shows preference for C20 or C22 highly polyunsaturated fatty acids and no activity with C18 fatty acids in vitro (PubMed:10559269).  Fatty acid allene oxides are intermediates in the formation of cyclopentenones or hydrolytic products in marine systems, most notably the prostanoid-related clavulones (PubMed:29909837).
What are the official names of this protein?
Allene oxide synthase-lipoxygenase protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the lipoxygenase family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane; Peripheral membrane protein. Note=Calcium binding promotes binding to membranes.
Protein: Y2898_MYCTU
Sequence: MTTLKTMTRVQLGAMGEALAVDYLTSMGLRILNRNWRCRYGELDVIACDAATRTVVFVEVKTRTGDGYGGLAHAVTERKVRRLRRLAGLWLADQEERWAAVRIDVIGVRVGPKNSGRTPELTHLQGIG
What are the official names of this protein?
UPF0102 protein Rv2898c.
What is the protein family that this protein belongs to?
Belongs to the UPF0102 family.
Protein: KANL1_MOUSE
Sequence: MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILISANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPAKESLKLQGVFSKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKKLTKSSTHSDHDNSSSLNGGKRSLTSSSLQGGEVGGPDSGNLKGGMTNCTLPHRSLDIQHTTLYSNNSTANKSSVNSMDQPALQGSSRLSPSTDSSSNLTNVKLEVKKSPLSSILFSALDSDTRITALLRRQADIEIRARRLQKRLQVVQAKQVERHLQHQLGGFLETTLSKLPNLESLRSRSQLMLTRKAEAALRKAASESATSEGLSNFLKSDSISEELERFTASGIANLRCSEQAFDSDVTDSSSGGESDIEEEELTRADPEQCHVPLKRRSEWRWAADRAAIVSRWNWLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEAPFPDHTTDLLSLSSEVKTDHGRDKLIESVSQPSENHGILVSNITESLSTKSCGAPRPVNGVVNSLQPVLADQVPGDSSDAEEQLHKKQRLNLVSSSDGTCVAARTRPVLTCKKRRLVRPSSIVPLSKKVHRNVRSGCDVNPSCALCGSGSVNTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKSQWQNKPFDKIKPTKKFSLKHRATMPCSLSDPVRKDRHKLVNSFLTTAMLKHHTDMSSPSYLTATHHPPHSPLVRQLSTSSDTSTPTSSGSQVAASTSQPVRRRRGESSFDINNIVIPMSVAATTRVEKLQYKEILTPSWREVDVQSLKGSPDEENEEIEDLSDAAFAALHAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSHSLSEFSHGQSPRSPISPELHSAPLTPVARDSLRHLASEDTRCSTPELGLDEQSVQPWERRTFPLAYSPQAECEEQLDAQDTAARCTRRTSGSKTGREAEVAPTSPPVVPLKSRHLAATVTAQRPAHR
What is the function of this protein?
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
What are the official names of this protein?
KAT8 regulatory NSL complex subunit 1, NSL complex protein NSL1, Non-specific lethal 1 homolog.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore.
Protein: RS5_OENOB
Sequence: MAEYINPNALGDLEENVVSINRVTKVVKGGRRLRFSALVIVGDRNGHVGFGTGKAQEVPEAIRKAVEDAKRHLIKVPTVGTTIPHQVLGVDGGGKVLLKPASEGSGVAAGGSTRPIMELAGIPDVTAKSLGSSTAVNVVRATFDGLKNLKEAKVVAALRGVSLGE
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: CSTN1_HUMAN
Sequence: MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDSTLSY
What is the function of this protein?
In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP (PubMed:15037614).
What are the official names of this protein?
Calsyntenin-1, Alcadein-alpha, Alc-alpha, Alzheimer-related cadherin-like protein, Non-classical cadherin XB31alpha.
What is the protein family that this protein belongs to?
Belongs to the calsyntenin family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane. Cell projection, neuron projection. Postsynaptic cell membrane; Single-pass type I membrane protein. Nucleus. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1.