PharMolix/UniProtQA huggingface dataset:
Protein: CLU_ASPCL
Sequence: MSQTNGNMEHSKETPQSQEVEQLTNGNHPEEQQEEEENNGGLFQISVKLPHEPHKIQVMVSSQEQVQDVRQSIVELPGTFQYTCFHLEFNGKRINDFVELSEVEDLKADSEIVLVEDPYTEKEARMHTVRIRDLVGAAGDRVDNLQGLDAGLSLHDSVTAEAAASEEKEHSLSKYDITASPSLKTILPRDEAPLPKTVKSISLSAWNPPPYHLRQKGHLLYLQVATNEGEQFQVTSHVSGFYVNKCSNAKFDPSPRTIPKKVSAHSLLTLISKISPSFNTAFEALQESNNQKDLLTTFPFQNAIPNSPWLVPPPSSNVNVHQADITRSQESYLISGVDNAETLRDWNEEFQTTRELPRETVQDRVFRERLTSKLFADYNEAAARGAVLVARGEVAPLNPTEDRDAQIFVYNNIFYSFGADGVGTFASEGGDEAARVAVGKDVLGIKAVNQLDINGLFTPGTVVVDYLGKRIVGQSIVPGIFKQREPGEHQIDYGGVEGKDVVATHPDFVSVFEKMSKALRIKKHAVWDKDSKRHDLEGSVETKGLLGTDGRKYVLDLYRVTPLDVMWQEEPNSEEYPHRMSVLRLELVEAYWRSKMSQYVKAEVERRRAVKAEAEKEKPAESSESKEQDSEEKTEEKTEESSDQERVDISGFQLALNPDVCSGQVPQTDEEKQQWAEDEKEVRDACDFLRSKVMPELVQDLHDGDVGFPMDGQSLGQLLHKRGINIRYLGKLAQLSKEKGARLDALTTLLIQEMIARAFKHIANRFMRNVPAPFVASCVAHLLNCLLGADVNANPRAEIDASLREFYPEGDFTFETVTPETLRAEIEQQVALRYRFTLESEWFASLRHLQLLRDIAIKLGLQLGAREYAFTKDQLPPKVPVVNGANNAAQDEGKKKKKKGADKSPSRAIVEEKPAVSIVPDDIVNVVPLVKDASPRSSLAEEALEAGRISLMQNQKQLGQELILESLSLHEQIYGILHPEVAKLYHQLSMLYYQTDEKEAAVELARKAVIVTERTLGVDSADTILAYLNLSLFEHASGNTKTALVYIKHAMDLWKIIYGPNHPDSITTMNNAAVMLQHLKQYADSRKWFEASLSVCESLFGKQSINTATILFQLAQALALDQDSKGAVGKMRDAYNIFLSQLGPDDRNTKEAETWLEQLTQNAVSIAKHAKDIQARRLRRINMNPRVTTLGTKVQPQVGQTAPEASGAKNAANASLDSRSIDELLKFIEGGDTSSSRSKQKKRAAASNPKLRGSKKSSA
What is the function of this protein?
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.
What are the official names of this protein?
Clustered mitochondria protein homolog, Protein TIF31 homolog.
What is the protein family that this protein belongs to?
Belongs to the CLU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUSB_YERPN
Sequence: MKPAARRRARECAVQALYSWQLSKNDIADVELQFLSEQDVKDVDIAYFRELLSGVAVNAASLDALMAPFLSRQLEELGQVERAVLRIALFELSKRDDVPYKVAINEAIELAKTFGAEDSHKFVNGVLDKVAPTVRKRK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: LEU3_DEIRA
Sequence: MPKVITLPGDGIGPEVTAAAVQVLREVAPDVTVEEHAIGGGAYDAHGEPFPTSTRDALKEADAVLLGTVGGAHDSAWNQLPRHLRPESGLLALRKALGCYANLRPVRVQPGLEHLSPLKAELARGVDILIVRELLGGIYFDQDRKIEGDTAYNTMRYTTSEVERVAKVAFWAAEQRKGRVTSVDKANVLEVSELWRRDVQALRDRDYRSIHLNHEYVDSVAMLIVADPSRYDVILTENLFGDILSDLAAVIPGSLGLMPSASLGDGAGLFEPIHGSAPDIAGQGVANPAAAIMSVGMLLRHGLERSEAANQVDRAVALALREQPTRDLGGSADTQTFTRAVLKALGSSPSVG
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HTRA2_DROAN
Sequence: MALRGSHRLDDFIRRCSALTLFHSQAPSRRVSHCGRDRRQQQDPPGQGRQEQQESGGGHWSRFGWRSLIRFFVPFSLGAVASSLVIKREELTPTITAKAMSGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVSNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAERRKKGAAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKHLDIVILRGVKQMHVTITPEDP
What is the function of this protein?
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein.  Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism.  Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity).
What are the official names of this protein?
Serine protease HTRA2, mitochondrial, High temperature requirement protein A2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S1C family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment. The extramitochondrial protein does not diffuse throughout the cytosol but stays near the mitochondria.
Protein: RPOZ_STRA3
Sequence: MLKPSIDTLLDKVPSKYSLVILQAKRAHELEAGEKATQDFKSVKSTLRALEEIESGNVVIHPDPSAKRASVRARIEAERLAKEEEERKIKEQIAKEKEDGEKI
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PSBD_CUSOB
Sequence: MTITLGQSTKNDKDLFDTMDDWLRRDRFLFVGWSGLLLFPCAYFALGGWFTGTTFVTSWYTHGLASSYLEGCNFLTAAVSTPANSLAHSLLLLWGPEAQGDFTRWCKLGGLWTFVALHGAFGLIGFMLRQFELARSVQLRPYNAIAFSAPIAVFVSVFFIYPLGQSGWFFAPSFGVAAIFRFILFFQGFHNWTLNPFHMMGVAGVLGAALLCAIHGATVENTLFEDGDGANTFRAFNPTQSEETYSMVTANRFWSQIFGVAFSNKRWLHFFMLFVPVTGLWMSALGVVGLALNLRAYDFVSQEIRASEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFPEEVLPRGNAL
What is the function of this protein?
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.  The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.  D2 is needed for assembly of a stable PSII complex.
What are the official names of this protein?
Photosystem II D2 protein, PSII D2 protein, Photosystem Q(A) protein.
What is the protein family that this protein belongs to?
Belongs to the reaction center PufL/M/PsbA/D family.
What are the subcellular locations of this protein?
Plastid membrane; Multi-pass membrane protein.
Protein: RSMH_FERNB
Sequence: MNRVYNDHHIPVLLNEVVENLIWKPDGVYVDCTVGEGGHTRAIAERVLPYGGRVIGIDVDSEVLQIAEHNLLSYPNVQLFKFSYVELPVLLSLLQVHKVDGLLVDLGVSTYQLKAEGRGFSFNQDEPLDMRMNLENNLTAYHIVNTYPEEKLADIIYNYGEENFSRRIARAIVQNRPIQTTRQLVEVIKRALPYKEVHNRKRHFATKTFQAIRIEVNKEIENISKFLEFAPDYLNSGGRLAIISFHSLEDRIVKHVFKNDKRLKPIGDFISPTTFEVAENPRARSAKLRLAERV
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYC_HUMAN
Sequence: MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIWGEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE
What is the function of this protein?
Plays a role in apoptosis.  Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol.  Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
What are the official names of this protein?
Cytochrome c.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Protein: ACKA_HAEIN
Sequence: MSKLVLILNCGSSSLKFAILDPATGEEKLSGLAEAFFLPEARIKWKLNGEKGNADLGAGAAHTEALNFIASNILNDELKNSIAAIGHRIVHGGEKYTQSVIVTDEVVKGIEDAAQFAPLHNPAHLIGIREAFKAFPHLKDKNVVVFDTAFHQTMPEEAFLYALPYSLYKEHGVRRYGAHGTSHYFVSREVAKYVGKPADQVNAIICHLGNGGSVSVVRNGQCIDTSMGLTPLEGLVMGTRCGDIDPAIVFYLYKTLGMSMDQIEETLVKKSGLLGLTEVTSDCRYAEDNYDDESKPETRRALNVYSYRLAKYIGAYMAVLGDDHLDAIAFTGGIGENSAHVRELALNHLKLFGIKIDNERNLATRFGKDGVITTDDSAFKAIVLPTNEELVIAQDTAKLCF
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: H4_DICDI
Sequence: MSSAQSRGGKTGGKVGGKVGAKRHKKTQKEHINGITKPAIRRLARRGGVKRISFPIYEETRNVLRTFLTNVIRDSVAYTEHAGRRTVTAMDVVYALKRQGRTLYGFNS
What is the function of this protein?
Core component of nucleosome.  Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.  Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.  DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
What are the official names of this protein?
Histone H4.
What is the protein family that this protein belongs to?
Belongs to the histone H4 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome.
Protein: TM2D2_DANRE
Sequence: MPQISVNYILLCGQFLLFFTVLLLQCLEGIHSQNSTEPPGNRVTTSKPVLFSEQPEENVTESGSVIPTETSNHTEQYEYNPPSPVVLCRYLPEEFIFCQDPVDHGGNVSAFQELGYGCVKFGGQVYKDVNHTQVLCTALDGIECAGPREFLRGNEPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKLLTLGGLGIWWFVDLILLITGGLTPSDSSNWCTFY
What are the official names of this protein?
TM2 domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the TM2 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: MIAA_CALS8
Sequence: MQKIPLIVIAGLTATGKTDVAIELAQLIDGEIVSADSMCVYKYMDIGTAKPTKEQRQIVKHYVIDVVFPNEDYNVALFQKDATKAIDEIYQKGKIPLLVGGTGFYIKSIVDDIEFPEMGDSKQVRQNLYKELEEKGNMYLYEMLKNVDSKAAQSVHPNNVKRVIRYLEIYFLTGKKPTDFLEKVRKKGSKKYNILPLCFVMERSLLKERIDARVEKMFKIGLVDEVKMLLEMGYSKDLKSMQGLGYKQVIPYIEGNITLEEAKEELKLRTKQFAKRQSIWFKYQGDFIYLDVGNLEFKEVVKKCFELCKSVV
What is the function of this protein?
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
What are the official names of this protein?
tRNA dimethylallyltransferase, Dimethylallyl diphosphate:tRNA dimethylallyltransferase, DMAPP:tRNA dimethylallyltransferase, DMATase, Isopentenyl-diphosphate:tRNA isopentenyltransferase, IPP transferase, IPPT, IPTase.
What is the protein family that this protein belongs to?
Belongs to the IPP transferase family.
Protein: Y827_HAEIN
Sequence: MSANFTDKNGRQSKGVLLLRTLAMPSDTNANGDIFGGWIMSQMDMGGAILAKEIAHGRVVTVAVESMNFIKPISVGDVVCCYGQCLKVGRSSIKIKVEVWVKKVASEPIGERYCVTDAVFTFVAVDNNGRSRTIPRENNQELEKALALISEQPL
What are the official names of this protein?
Uncharacterized acyl-CoA thioester hydrolase HI_0827.
What is the protein family that this protein belongs to?
Belongs to the acyl coenzyme A hydrolase family.
Protein: RS10_CHLAD
Sequence: MAKQKVRIRLKAYDHKILDQSARQIVEAAERTGALVAGPVPLPTKIERYSVIRSGFIDKDSQEQFEIRTHKRLIDVLDPSQQTINALMKLNLPAGVDIEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: ARSR_STAAU
Sequence: MSYKELSTILKILSDSSRLEILDLLSCGELCACDLLEHFQFSQPTLSHHMKSLVDNELVTTRKDGNKHWYQLNHAILDDIIQNLNIINTSNQRCVCKNVKSGDC
What is the function of this protein?
Transcriptional repressor for the ars operon.  ArsR is a trans-acting regulatory protein which controls its own expression.  The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
What are the official names of this protein?
Arsenical resistance operon repressor.
Protein: GCSPA_PYRFU
Sequence: MGKHYIPNSAHKEEMLKEIGFSSIEELFADVPEGFIREFNVPEGKSEYEVFMEMNEILSKNKTVLEMPTFLGAGTYFHYVPAHVKYLIERSEFLTSYTPYQAEISQGMLQALFEYQSLIAELVGLPVVNSSMYDWGSALGEAALMTVRLHRGKRLKFVVPKHTHPERMQVLKTYTRGANLEIVEVKWNDRGQVDLEDLKEKVNDAAGVYVEIPNFFGLLEENIQEIGEIAHEAGAYFVVGVDPTILGVVEAPGELGADIVVGEASYFGSPMNFGGPRAGIFATRNDPKFIRQMPGRIIGMTKDAEGKRAFVMTLQTREQHIRRAKATSNICSNEALVAVAAAIHIASLGPKGMQELGEVILKNTAYLKKRLSEVAEIPFDGVNFKDVLVKFEKPYQEIHEHLLQKNIHGGYYVKPHFPELGESALFAATETTRKEWIDALIDALREVL
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.  The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
What are the official names of this protein?
Probable glycine dehydrogenase (decarboxylating) subunit 1, Glycine cleavage system P-protein subunit 1, Glycine decarboxylase subunit 1, Glycine dehydrogenase (aminomethyl-transferring) subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GcvP family. N-terminal subunit subfamily.
Protein: CH10_STRP2
Sequence: MLKPLGDRVLLKIEEKEQTVGGFVLAGSAQEKTKTAQVVATGQGVRTLNGDLVAPSVKTGDRVLVEAHAGLDVKDGDEKYIIVGEANILAIIEE
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: M4K2_HUMAN
Sequence: MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKELPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFERCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
What is the function of this protein?
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway.  Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway.  Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin.  To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation.  The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8.  Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation.  Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3.  May play a role in the regulation of vesicle targeting or fusion.  regulation of vesicle targeting or fusion.
What are the official names of this protein?
Mitogen-activated protein kinase kinase kinase kinase 2, B lymphocyte serine/threonine-protein kinase, Germinal center kinase, GC kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Basolateral cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Protein: KATG_MYCTE
Sequence: MPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNLKVLHQNPAVADPMGAAFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIRMAWHAAGTYRIHDGRGGAGGGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWADLIVFAGNCALESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAAVQMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGAGPADLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTNTPTKWDNSFLEILYGYEWELTKSPAGAWQYTAKDGAGAGTIPDPFGGPGRSPTMLATDLSLRVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDMGPVARYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASLKSQIRASGLTVSQLVSTAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKVIRTLEEIQESFNSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQEQTDVESFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPEMTVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPADDGTYQGKDGSGKVKWTGSRVDLVFGSNSELRALVEVYGADDAQPKFVQDFVAAWDKVMNLDRFDVR
What is the function of this protein?
Catalyzes the oxidative activation of the antitubercular pro-drug isoniazid (INH) to generate an isonicotinoyl radical that then reacts nonenzymatically with NAD to form an isonicotinoyl-NAD adduct which inhibits InhA.
What are the official names of this protein?
Catalase-peroxidase, CP, Peroxidase/catalase.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Protein: AEE19_ARATH
Sequence: MPKVVALYMPPSVEYVISVFSVLRCGEAFLPLDPSWPRERVLSLISSSNISLVIACGLSSVESHWLVERNVCPVLLFSMDEKLSVETGCSSFVWPCKKERQRKFCYLMYTSGSTGKPKGVCGTEQGLLNRFLWMQELYPVVGEQRFAFKTSVGFIDHIQEFLGAILSSTALVIPPFTLLKENMISIIDFLEEYSISRLLAVPSMIRAILPTLQHRGHNNKLQSCLKLVVLSGEPFPVSLWDSLHSLLPETCFLNLYGSTEVSGDCTYFDCSELPRLLKTEEIGSVPIGKSISNCKVVLLGDEDKPYEGEICVSGLCLSQGYMHSSIESEGYVKLHNNSLCNHLTNDCGSQLYYRTGDYGRQLSSGDLIFIGRRDRTVKLNGKRMALEEIETTLELNPDIAEAVVLLSRDETELASLKAFVVLNKESNSSDGIIFSIRNWMGGKLPPVMIPNHFVLVEKLPLTSSGKVDYEALARLKCPTTGAQDMMQSNGTNSLLQNIKKAVCDALLVKEVSDDDDFFAIGGDSLAAAHLSHSLGIDMRLIYQFRSPSRLLIYLSEKEGKLREDMQHNTTQKLDHKIESQNGNGLVSRTVPLHSGVTSGPTPSKLQCEKNNSPKRLKIDYEKFSPKRMKENKLWDSGFSQIQCAFSRCNKVHSPESCSNEEANREYWSLEIPRNQMVSMQEIWKVHMESCVDASPLVVLKDSKTYLFIGSHSRKFSCIDAKSGSMYWETILEGRIEGSAMVVGDFSQVVIGCYKGKLYFLDFSTGSLCWKFQACGEIKCQPVVDTSSQLIWCGSHDHTLYALDYRSQCCVYKLQCGGSIFASPAIDEGHSSLYVASTSGRVIAVSIKDSPFHTLWLFELEAPIFGSLCITPSTQNVICCLVDGQVIAMSPSGTIIWRYRTGGPIFAGPCMSHVLPSQVLVCCRNGCVYSLEPESGCLVWEDNIGDPITASAYIDENLHFESHELLASDRLVTVCSSSGRVHVLRVRPSILSRDSHDSKVGEITRMELQADIFSSPVMIGGRIFVGCRDDYVHCLSLESCR
What are the official names of this protein?
Putative acyl-activating enzyme 19.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: UPPP_KORCO
Sequence: MEIAQALILGIVQGLTEWLPISSSGHLVLLQIILLSRSSAAFIALVHAGTLLAVIVAFRRDVFNVIKSFLEGISELPKGSAFSSPERKLPLYILIGTVPVAVLGLALAKYVDEIFGSSKIVGVGLLITAALLYSTKWAGGERPLDLRRALIVGLAQSIAIFPGISRSGATISTALLSGLKREEAIRYSFLLSIPALTGFLILELIVSPAHEILNPEGLVGLLSSFITGLIAIKFLLSIIRRGRLHLFSYYCVIVGIAILSLL
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
What are the official names of this protein?
Undecaprenyl-diphosphatase, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: IFGF1_PENRF
Sequence: MTILVLGGRGKTASRLAALLDAAKTPFLVGSSSTSQESPYNSSHFNWYEKTTWDNPFAEIGKHGLQPISAVYLVGPPTMDMVPPMIQFVDLACSKGVQRFVLVSASNIEKGDHSMGQVHAYLDSLPGVEYVALRPTWFMENLLEDPQRTWIKNESQVVSATGEGKIPFISADDIASVAFHCLTEWGSHKTEYIIQGPELLSYGQVAEILTSILGKKITHRSLSEAEYTNILVDEIGMPADFAAMSAAMEVDVKNSPQETLNGSVEEVTGNPPRFFRTFAEHEKQKWV
What is the function of this protein?
Festuclavine synthase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28620689).  The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689).  The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689).  The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217).  The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217).  The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689).  Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689).  Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217).  The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).
What are the official names of this protein?
Festuclavine synthase I, Festuclavine dehydrogenase ifgF1, Isofumigaclavine biosynthesis cluster A protein F1.
What is the protein family that this protein belongs to?
Belongs to the fgaFS/easG family.
Protein: HSDL2_RAT
Sequence: MLPNTGKLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTTQRHPKLLGTIYTAAEEIEAAGGKALPCVVDVRDEQQINSAVEKAVERFGGIDILVNNASAISLTNTLETPTKRVDLMMSVNTRGTYLTSKACIPFLKKSKVAHILNLSPPLNLNPMWFKQHCAYTIAKYGMSMCVLGMAEEFRGEIAVNALWPRTAIHTAAMDMLGGAGVESQCRKVDIIADAAYSIFKRPKSFTGNFIIDENILKEEGIKDFDIYAITPGHPLLPDFFLDEHPDAVMEEKESYDPVPEVKEEKLQLQEQPQLQEQPQLQEKPQLQEQPQLQEKPQLQEQPQLQEQPQLQEQPQQQPQLQEQPQLQEKPQLQEQPQQQEKPQPQQQPQQQPQQRPQQRPQPQPQPQPLLQSVLPPKPHFGAVEETFRIVKDSLSDEVVRATQAVYQFELSGEDGGTWFLDLKSKGGKVGHGEPSDRADVVMSMATEDFVKMFSGKLKPTMAFMSGKLKIKGNIALAIKLEKLMTHMNSRL
What is the function of this protein?
Has apparently no steroid dehydrogenase activity.
What are the official names of this protein?
Hydroxysteroid dehydrogenase-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
What are the subcellular locations of this protein?
Peroxisome.