PharMolix/UniProtQA huggingface dataset:
Protein: CENPS_BOVIN
Sequence: MEEEEWSEEQQRFSYLQRLKAAVHYTVGCLCEEVASDKDMQFSKQTIAAISEVTFGQCENFAKDLEMFARHAKRSTINTEDVKLLARRSHSLLKYITEKNEDIAQLNLEKKAKKKKKLEDENRNSVESAEAGVEESEN
What is the function of this protein?
DNA-binding component of the Fanconi anemia (FA) core complex.  Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage.  In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA.  Stabilizes FANCM.  In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks.  In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression.  As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.  DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded.  Does not bind DNA on its own.
What are the official names of this protein?
Centromere protein S, CENP-S, Apoptosis-inducing TAF9-like domain-containing protein 1 homolog, FANCM-interacting histone fold protein 1.
What is the protein family that this protein belongs to?
Belongs to the TAF9 family. CENP-S/MHF1 subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPS is more stably bound at the kinetochore than CENPX. During S phase, rapidly recruited to DNA interstrand cross-links that block replication. Recruited to DNA damage sites about 20 minutes following UV irradiation, reaching a plateau after approximately 40 minutes.
Protein: COXX_POLAQ
Sequence: MSTSNSSIPASMPRWRQYWVLTKPRVTQLAVFCAVIGMFLATPGMVPYPVLFGGIAGIWLLAGAAFAVNCLIEQAVDAKMKRTSWRPSATGEVTPFHIIIFSIILGSLGMIILWNFCNPLTMWLTLATFVGYAVIYTWLLKPATPQNIVIGGLSGAMPPALGWAAVTNGLSAEAWLLVLIIFVWTPPHFWALALYRRDDYVQSGLPMLPVTHGERFTLLNILLYTLILIAATLLPYIYGMSGIIYLISAIVLGLMFLAYVIALFVSYSDALAKKTFRFSITYLSLLFAALLIDHYFL
What is the function of this protein?
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
What are the official names of this protein?
Protoheme IX farnesyltransferase, Heme B farnesyltransferase, Heme O synthase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: VP302_LYCMC
Sequence: MLKLVILLCVIESIYSLSCPCQWNKSLRDSCRIPENCLAGTTKDVCGCCDVCAKIEGESCGGPWNIGGSCAVGLTCVKVDKRNFHSKGVCKLN
What are the official names of this protein?
Venom protein 302.
What are the subcellular locations of this protein?
Secreted.
Protein: LCL3_PENRW
Sequence: MRWPPWSSESTNDEQKQTPSSWLSSAANKPSSILDWTAFTELRTIIPTVVLTSGILIAVRFHRRYLRRIPDAPSISSSYLRRRSIFGQVTSVGDGDNFRIFHTPGGRMAGWGWLPWKKVPTVKKDLKDKTIHIRLAGVDAPELAHFGRPEQPFARDAHTWLTSYLSNRRVRALVHRQDQYSRVVASVFVRRAFDFPPFRRRDVSYEMLKRGLATVYEAKIGSEFGGDKMEKKYRKAEWWAKKRARGLWKDYRRVGSGWESPREYKNRMGMGDPLPIEKGNGKGNGKGKIGQK
What are the official names of this protein?
Probable endonuclease lcl3.
What is the protein family that this protein belongs to?
Belongs to the LCL3 family.
What are the subcellular locations of this protein?
Mitochondrion. Membrane; Single- pass membrane protein.
Protein: METE_ENT38
Sequence: MTVINHTLGFPRVGLRRELKKAQESYWAGQSTREDLLAVGRELRARHWDQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVPARHQNKDGSVDIDTLFRLGRGRAPTGEPAAAAEMTKWFNTNYHYMVPEFVKGQQFKLTWTQLLDEVDEALALGHNIKPVLLGPVTYLWLGKVKGEQFDRLSLLNDILPVYQQVLAELAKRGVEWVQIDEPALVLELPQEWLDAFKPAYDALTGQTKLLLTTYFEGVTPNLDTITALPVQGLHVDLVHGKDEVAELNKRLPSDWLLSAGLVNGRNVWRADLTEKYAQIKDIVGKRDVWVASSCSLLHSPIDLSVETRLDAEVKSWFAFALQKCEELALLRDALNSGDTAKLVEWSAPIQARRHSTRVHNAAVEKRLAAITAKDSQRENAYEVRAEAQRARFNLPAWPTTTIGSFPQTTEIRGLRLDFKKGNLDANNYRTGIAEHIKQAIIEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPVVIGDVSRPEAITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVTRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLQWGVEAFRINAAVAKNDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEEFDYPNEIGPGVYDIHSPNVPSVEWIEALLAKAAQRIPAERLWVNPDCGLKTRGWPETRAALANMVKAAQNLRQG
What is the function of this protein?
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
What are the official names of this protein?
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme.
What is the protein family that this protein belongs to?
Belongs to the vitamin-B12 independent methionine synthase family.
Protein: ACDH3_NOCFA
Sequence: MNHMSDPTTVKVAVIGSGNIGTDLMIKVIRHSRVLEMGAMVGIDPDSDGLARARRLGVPTTSDGVEGLLALPGFADIEVIFDATSAKAHAANAALLQPLGKRLIDLTPAALGPFVVPAVNVDEHRDAPNVNMVTCGGQATIPIVAAVSRVAPVAYAEIVASIASKSAGPGTRANIDEFTETTAHAVETVGGARRGKAIIILNPAEPPLIMRDTVLCLATAPDPATRSAIRESIEEMVARVAGYVPGYRLKQQIQITEIPPDQPVHTLAADGGPAPTHQVSVFLEVEGAAHYLPSYAGNLDIMTSAALRYAESIAATVTAAPADQGATR
What are the official names of this protein?
Acetaldehyde dehydrogenase 3, Acetaldehyde dehydrogenase [acetylating] 3.
What is the protein family that this protein belongs to?
Belongs to the acetaldehyde dehydrogenase family.
Protein: GET3_LACTC
Sequence: MDLIAEPNLKELINSTTHKWIFVGGKGGVGKTTSSCSISIQMALAQPKKQFLLISTDPAHNLSDAFGEKFGKDARKVTGMDNLSCMEIDPSAALKDMNDMSVAQNDKNDGFSDLLQGGGLAELTGSIPGIDEALSFMEVMKHIKRQEEGEGEKYDTVIFDTAPTGHTLRFLQLPQTLSQLLQKFGEIAGRFGPMLNSLTGGGQNMDIMGKVDELKANVEKIREQFTNPDMTTFVCVCISEFLSLYETERLIQELMSYEMDVNSIIVNQLLFADDDAEHNCRRCQARWNMQKKYLDQIGELYDDFHVVKMPLCAGEIRGLNNLKKFSQFLNKEYDPVADNKIIYELEEQK
What is the function of this protein?
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion.  This process is regulated by ATP binding and hydrolysis.  ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins.  ATP hydrolysis is required for insertion.  Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting.  Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.  Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
What are the official names of this protein?
ATPase GET3, Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3.
What is the protein family that this protein belongs to?
Belongs to the arsA ATPase family.
What are the subcellular locations of this protein?
Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Note=GET1 and GET2 are required for targeting GET3 to the endoplasmic reticulum.
Protein: UTP25_PICGU
Sequence: MQESGACRKKPAMPSRNAGSHLVVMKRIQRNGDGAMKRQKHGRRELREVKRTSRRSAKSEDFSGAEDENNGENETEVAVNNSESGEQEGVDDTGMAYNALLTLLGSEKPEKPTKRRKNDEAGVEEINEDDLEIHLTKSDDESDEENEPEVASDDEESDEKFNAFDFHFNQPSEDYMEKASQSVTSKWNNTTKETIDEYVVSTSTPSCMNKESVKLGISSIKKRVRDVYSEKHPSKISGIDASLLDSMLNYKSVLYPYKHYNNTFYRELYSMHAINHVFKTRDNILKNTEKIKHAQEMALEGKSHEDKEYRDQGFTRPKVLILLPTRNAAYEVVENILKYSGSEQQENKKKFKAQFNSNDVPPETKPQDFRDAFKGNNNDFFCLGMKFTRKSAKLYSSFYSSDIIIASPLGLSMILENPDKKKRQYDFLSSIEVFIVDRATQIEAQNWAHVNLVLKYLNKVPKEFHDADFSRIRMWYINDQAPLVRQTLVFCEYTTPPITSLVSSKSVNIGGRVRYKPIYTSKNCIMNSIGLRLKQIFQRFSSSSPMEDSENRFKFFINSMLPSLLSSTSYSDGILVYIPSYFDYVRIKNYMRNSTKFTFEGIDEYSTQSKLTRYRQQFISGKVKILLYTERLHYFRRFEINGVKTLLMYGVPSNPLFYKELVRCIGKSVFKEVADIDLSFVKVMYSQWDAIALERIVGGDRAPVLCSGTNEMYEFR
What is the function of this protein?
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
What are the official names of this protein?
U3 small nucleolar RNA-associated protein 25, U3 snoRNA-associated protein 25, U three protein 25.
What is the protein family that this protein belongs to?
Belongs to the UTP25 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DF285_ARATH
Sequence: MTNLYFKTAFLLSLLLLSFSYQSKLIEAKEDKECNDSKCLPNPSRINLEEGNIKRIDVNHGGICDTYLECGGLACSDYRRACCVNGKCVCRKQGQTLPDCPN
What are the official names of this protein?
Defensin-like protein 285.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: EDN1_HUMAN
Sequence: MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW
What is the function of this protein?
Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).  Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031).  Also binds the DEAR/FBXW7-AS1 receptor (PubMed:17446437).
What are the official names of this protein?
Endothelin-1, Preproendothelin-1, PPET1.
What is the protein family that this protein belongs to?
Belongs to the endothelin/sarafotoxin family.
What are the subcellular locations of this protein?
Secreted.
Protein: MURC_BURMS
Sequence: MKHIVKHIHFVGIGGAGMSGIAEVLVNLGYQVSGSDLARNAVTERLEALGARVSIGHDAANIEGANAVVVSTAVRSDNPEVLAARRLRVPIVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAAGGLDPTFVIGGRLTSAGANARLGMGDFIVAEADESDASFLNLYPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGSAVVCIDDANVRQIVPLISKPVVRYGFAADAQVRAENVEARDGRMHFTVRREGREPLPVVLNLPGLHNVQNALAAIAIATDLDVADAAIQQALAEFNGVGRRFQRYGEIAAAGGGAYTLIDDYGHHPVEMAATIAAARGAFPGRRLVLAFQPHRYTRTRDCFDDFVNVLSTVDALVLTEVYAAGEAPISTANGDALSRALRAAGKVEPVFVATVDEVPDALAKLARDGDVVITMGAGSIGGVPGKLAQDTQQKG
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FABZ_VEREI
Sequence: MDIHAIVKQLPHRYPFLLVDKVIELERNTRIKAIKNVTCNEPYFMGHFPGRPVMPGVLILEALAQAAGLLAFDAMGKVPDENNLYYLVGIDGARFKRPVEPGDQLILAITIDRVRGGIWKFKGLASVGDEVACEAELMCTMRSVGEPDRS
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RTCA_SULIN
Sequence: MIEIDGSFGEGGGQILRTSLTLSIITGKPFRIFNIRANRPNPGLQRQHLWAVKAMKMISNAETKGDEVGSKELIFVPHEIKGNTNIDMDVGTAGSVTLIIQTVLPAIINKNVRIRIKGGTDVPKSPTIDYIRLVYLEILRKIGIEAKLNLIKRGHYPEGGGEVIIENVNGNPSAFSLLELGKLTIIKGISHVSSLPAHIAERQMNSAREILSKLGVPIEIETDVRQGEVSKGSGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARILINNLNTKASVDIHMSDMLMIFASLYGGEYIGAELTSHAYTNMEIIKKFLDIKIDVSGKRPFRFKAKIF
What is the function of this protein?
Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.  The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product.  The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
What are the official names of this protein?
RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase.
What is the protein family that this protein belongs to?
Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OLA1_BOVIN
Sequence: MPPKKGGDGIKPPPIIGRFGTSLKIGIVGLPNVGKSTFFNVLTNSQASAENFPFCTIDPNESRVPVPDERFDFLCQYHKPASKIPAFLNVVDIAGLVKGAHNGQGLGNAFLSHISACDGIFHLTRAFEDDDITHVEGSVDPVRDIEIIHEELQLKDEEMVGPIIDKLEKVAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPGALVIPFSGALELRLQELSAEERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGDIIFFKFNTPQQPKKK
What is the function of this protein?
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency.  Has lower affinity for GTP.
What are the official names of this protein?
Obg-like ATPase 1.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.
Protein: GRP1_HUMAN
Sequence: MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVRKRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQLEKSNHVLAQMEQGDCS
What is the function of this protein?
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103).  Activates the Erk/MAP kinase cascade (PubMed:15899849).  Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103).  Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860).  Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses.  May also function in differentiation of other cell types (PubMed:12845332).
What are the official names of this protein?
RAS guanyl-releasing protein 1, Calcium and DAG-regulated guanine nucleotide exchange factor II, CalDAG-GEFII, Ras guanyl-releasing protein.
What is the protein family that this protein belongs to?
Belongs to the RASGRP family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin- dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity).
Protein: RL25_BARHE
Sequence: MSKSYTLKAEIRERVGKGSSRELRRNGLIPAVIYGDKQPPLAIAVSYKDIFYKIHAGGFRTTVATLAIDKQKIMVLPKDYQLDPVRDFPLHVDFLRISAKSIVEVNIPVHFLNEDSAPGLKKGGVLNIVRHEIECTAPANAIPEAIEIDLSSYSIGDSIHISAVQLPKDVNPVIQDRDFTIATIVAPADMDVSDEVSEQENNEESE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: MTNA_DROAN
Sequence: MSLQSIKYSRGSLDILDQLLLPVQSKYVAVRGVEDGWKVINKMQVRGAPAIAIVGCLSLAVEIYPEEFESKKRLRQEVEGKLNYLVSARPTAVNMKIAADELLALANDLTKDETIDVAGMKERFLNATEAMLEKDIADNQAIGSHGAQAILKRVAEAAGAQTGTAGPVRVLTHCNTGSLATAGYGTALGVVRQLAELGKLEHVYCTETRPYNQGARLTAYELVHEKFPATLVLDSMVAALLRAKNVAGVVVGADRVAANGDTANKIGTYQIAVVAKHHGVPFYVAAPLTSIDLAIPGGDHIIIEERPDREMTHVGEHRIAAPGINCWNPAFDVTPASLITGIITERGVFKPEELKEAITKLLES
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase, Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: CHAC1_DANRE
Sequence: MKPQDIVAGKSSLWIFGYGSLVWKPDFKYKRSKVGYIKGYKRRFWHGDNFHRGDDEMPGRVVTLIEEDDVCTWGVAFEVTGSQMEESLKYLNVREAVRGGYLTRAVDFFPRGTNQPPVQALVYIATPDNPIYLGPASTEEIASQIAVCKGNSGHNIEYLLRLAEFMRVSCPDVDDPHLFSIEAALLATIRPILLAA
What is the function of this protein?
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide.  Acts specifically on glutathione, but not on other gamma-glutamyl peptides.  Glutathione depletion is an important factor for apoptosis initiation and execution.  Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade.  Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
What are the official names of this protein?
Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, Cation transport regulator-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
Protein: DISA_CLOD6
Sequence: MENFLDNKNMLYALKMISPGTPLRLGLNNVLRAKTGGLIVIATNEDVMKIVDGGFAINAEYSPSYLYELAKMDGAIVLSGDVKKILFANAQLIPDYFIETSETGTRHRTAERVAKQTGAIVIGISQRRNVITVYRGNEKYVVEDISKIFTKANQAIQTLEKYKTVLDQAVTNLNALEFNDLVTIYDVALVMQKMEMVMRVTSIIEKYVIELGDEGTLVSMQLEELMGTTRIDQKLIFKDYNKENTEIKELMKKVKNLNSEELIELVNMAKLLGYSGFSESMDMPIKTRGYRILSKIHRLPTAIIENLVNYFENFQQILDASIEELDEVEGIGEIRATYIKNGLIKMKQLVLLDRHI
What is the function of this protein?
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:25965978).  c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation.  The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
What are the official names of this protein?
DNA integrity scanning protein DisA, Cyclic di-AMP synthase, c-di-AMP synthase, Diadenylate cyclase.
What is the protein family that this protein belongs to?
Belongs to the DisA family.
Protein: SYC_CHLPN
Sequence: MAFSHIEGLYFYNTASQKKELFFPNHTPVRLYTCGPTVYDYAHIGNFRTYVFEDILKRTLVFFGYSVTHVMNITDVEDKTIAGASKKNIPLQEYTQPYTEAFFEDLDTLNIARADFYPHATHYIPQMIQAITKLLEQGIAYIGQDASVYFSLNRFPNYGKLSHLDLSSLRCCSRISADEYDKENPSDFVLWKAYNPERDGVIYWESPFGKGRPGWHLECSIMAMELLGDSLDIHAGGVDNIFPHHENEIAQSEALSGKPFARYWLHSEHLLIDGKKMSKSLGNFLTLRDLLHQEFTGQEVRYMLLQSHYRTQLNFTEEALLACRHALRRLKDFVSRLEGVDLPGESPLPRTLDSSSQFIEAFSRALANDLNVSTGFASLFDFVHEINTLIDQGHFSKADSLYILDTLKKVDTVLGVLPLTTSVCIPETVMQLVAEREEARKTKNWAMADTLRDEILAAGFLVEDSKSGPKVKPL
What are the official names of this protein?
Cysteine--tRNA ligase, Cysteinyl-tRNA synthetase, CysRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LPXH_ECOLC
Sequence: MATLFIADLHLCVEEPAITAGFLRFLAGEARKADALYILGDLFEAWIGDDDPNPLHRKMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHELIANQQPAFRVVLGAWHTEGSMVKVTADDVELIHFPF
What is the function of this protein?
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom.  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
UDP-2,3-diacylglucosamine hydrolase, UDP-2,3-diacylglucosamine diphosphatase.
What is the protein family that this protein belongs to?
Belongs to the LpxH family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: DNAK_BAUCH
Sequence: MGKIIGIDLGTTNSCIAIVEGTKTRVLENSEGDRTTPSIVAYTQDGEILVGQPAKRQSATNPKNTLFAIKRLIGRRFEDEEVQRDVDIMPYKIIAADNGDAWLEIKGQKIAPPQVSAEILKKMKKTAEDYLGESVTEAVITVPAYFNDTQRQATKDAGRIAGLEVKRIINEPTAAALAYGLDKEIGNRTIAVYDLGGGTFDISIIEIDDVDGEKTFEVLATNGDTHLGGEDFDSRLINYLVDEFKKDQGIDLRNDPLAMQRLKEAAEKAKIELSAAQQTDVNLPYITADSTGPKHMNLKITRAKLESLVEDLVNRTMDPLKVALTDASLSISDIKDVILVGGQTRMPLVQKKVTDFFCKEPRKDVNPDEAVAIGAAVQGGVLSGNVKDVLLLDVTPLSLGIETMGGVMTALIAKNTTIPTKHSQIFSTAEDNQSAVTIHVLQGERKRAMDNKSLGQFNLDGIAPAMRGIPQIEVTFDIDADGILHVSAKDNNSGREQKITIKASSGLSEEEIKKMVREAEANAESDRKFEELVQTRNQADNLMHSTRKQLAEYGNQLLQEDRNAIENAIQSLNTALKGESKTDIETNIQSLIQVSSKLLKLTQQQNQATNDNVKTDGNVVDAEFEEVKDKK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: MYB52_ARATH
Sequence: MMCSRGHWRPAEDEKLRELVEQFGPHNWNAIAQKLSGRSGKSCRLRWFNQLDPRINRNPFTEEEEERLLASHRIHGNRWSVIARFFPGRTDNAVKNHWHVIMARRGRERSKLRPRGLGHDGTVAATGMIGNYKDCDKERRLATTTAINFPYQFSHINHFQVLKEFLTGKIGFRNSTTPIQEGAIDQTKRPMEFYNFLQVNTDSKIHELIDNSRKDEEEDVDQNNRIPNENCVPFFDFLSVGNSASQGLC
What is the function of this protein?
Transcription factor that confers sensitivity to abscisic acid (ABA) and salt, but tolerance to drought (PubMed:21399993).  Regulates secondary cell wall (SCW) biosynthesis, especially in interfascicular and xylary fibers (PubMed:18952777, PubMed:23781226).
What are the official names of this protein?
Transcription factor MYB52, Myb-related protein 52, AtMYB52, Protein ABA-HYPERSENSITIVE 1.
What are the subcellular locations of this protein?
Nucleus.