PharMolix/UniProtQA huggingface dataset:
Protein: SYN_STRP6
Sequence: MSKKLISIVNVKDYVGQEVTIGAWVANKSGKGKIAFVQLRDGSAFFQGVAFKPNFIEKYGEESGLEKFDVIKRLNQETSVYVTGIVKEDERSKFGYELDITDLEIIGESHEYPVTPKEHGTDFLMDNRHLWLRSRKQMAVMQIRNAIIYATYEFFDQNGFIKFDSPILSENAAEDSTELFETDYFGKPAFLSQSGQLYLEAGAMALGRVFDFGPVFRAEKSKTRRHLTEFWMMDAEYSFLSHEESLDLQEAYVKALIQGVLDRAPQALDILERDVEALKRYITEPFKRVSYDDAITLLQEHEADEDTDYEHLEHGDDFGSPHETWISNYFGVPTFVVNYPASFKAFYMKPVPGNPERVLCADLLAPEGYGEIIGGSMREDNYDALVAKMDELGMDKSEYDFYLDLRKYGSVPHGGFGIGIERMVTFVAGTKHIREAIPFPRMLHRIRP
What are the official names of this protein?
Asparagine--tRNA ligase, Asparaginyl-tRNA synthetase, AsnRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPL_OLEA2
Sequence: MIALNTLAILSVASLAFAADGGAGDGLVLFGAAIGMAIAAAGCGIGQGMGLKAACEGTARNPEAGGKIMVTLILGLAFVESLAIYALVVNLMLLFR
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, ATP synthase F(0) sector subunit c, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: VF117_ASFK5
Sequence: MGYTIQLDKDGDYYWDDDSHDPYMRANAAAFHAAPHAAAFNAAAPHAAAFNAAAPHAAAFNAAAPHAAAFNTATHHAFHEPFIKLNLTDKNIFNGLGFILIVIFIYLLLITLQQMLTRHIYNTVQHCVKAHLDSKNLQSR
What are the official names of this protein?
Uncharacterized protein B117L, pB117L.
What is the protein family that this protein belongs to?
Belongs to the asfivirus B117L family.
What are the subcellular locations of this protein?
Host membrane; Single-pass membrane protein. Virion.
Protein: Y2546_BURCH
Sequence: MDARLLEIIVCPICKGPLHYDRAAQELICNADKLAYPIRDGIPVMLVDEARQTVEGTPVDPAGR
What are the official names of this protein?
UPF0434 protein Bcen2424_2546.
What is the protein family that this protein belongs to?
Belongs to the UPF0434 family.
Protein: RIMM_CAMJE
Sequence: MSEKDFVQVAKLGKTVGLKGYVKLHNLSDFSSQFKKDATFFIKNTKEMLKIKHYNANNSTVLFENYEDIEKAKELTNLILFQSIEKSRQTCKLKKDEFFYFDILECEVFEEDKRLGKVVDILETGASYLFEIQSDEKWVEKKYPKIFFIPYLDKFVKNIDIEKRQIFCTQDAFLILENS
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GCST_SALCH
Sequence: MAQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQLDEHHAVRTDAGMFDVSHMTIVDLHGSRTREFLRYLLANDVAKLTKTGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPYAIDITVRDDLSLIAVQGPNAQEKAATLFTDEQRHAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIAMPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEMDEGISPLAANMGWTIAWEPADRDFIGREALEMQREKGHEQLVGLVMTEKGVLRNELPVRFTDAQGNQQEGIITSGTFSPTLGYSIALARVPAGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: MYH7_CANLF
Sequence: MVDAEMAAFGAAAPFLRKSEKERLEAQTRPFDLKKDVFVPDDKEEFVKAKIVSREGGKVTAETENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDSEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVAYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGWLQKNKDPLNETVVALYQKSSLKLLSNLFANYAGADAPVEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVIDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLSRMEYKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFARIKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKGLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKGLNEE
What is the function of this protein?
Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction.  Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
What are the official names of this protein?
Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
What are the subcellular locations of this protein?
Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere. Note=Thick filaments of the myofibrils.
Protein: LCYE_SOLLC
Sequence: MECVGVQNVGAMAVLTRPRLNRWSGGELCQEKSIFLAYEQYESKCNSSSGSDSCVVDKEDFADEEDYIKAGGSQLVFVQMQQKKDMDQQSKLSDELRQISAGQTVLDLVVIGCGPAGLALAAESAKLGLNVGLVGPDLPFTNNYGVWEDEFKDLGLQACIEHVWRDTIVYLDDDEPILIGRAYGRVSRHFLHEELLKRCVEAGVLYLNSKVDRIVEATNGQSLVECEGDVVIPCRFVTVASGAASGKFLQYELGSPRVSVQTAYGVEVEVDNNPFDPSLMVFMDYRDYLRHDAQSLEAKYPTFLYAMPMSPTRVFFEETCLASKDAMPFDLLKKKLMLRLNTLGVRIKEIYEEEWSYIPVGGSLPNTEQKTLAFGAAASMVHPATGYSVVRSLSEAPKCASVLANILRQHYSKNMLTSSSIPSISTQAWNTLWPQERKRQRSFFLFGLALILQLDIEGIRSFFRAFFRVPKWMWQGFLGSSLSSADLMLFAFYMFIIAPNDMRKGLIRHLLSDPTGATLIRTYLTF
What is the function of this protein?
Catalyzes the single cyclization reaction which converts lycopene to delta-carotene and neurosporene to alpha-zeacarotene.  Required for lutein biosynthesis.
What are the official names of this protein?
Lycopene epsilon cyclase, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the lycopene cyclase family.
What are the subcellular locations of this protein?
Plastid, chloroplast membrane; Multi-pass membrane protein.
Protein: RL3_PARMW
Sequence: MSIGILGKKLGMSQFFDEQGRAVPVTLIEAGPCRITQLKSSDTDGYAAVQIGFGDTREKLINKPAKGHLNKTGETLLRHLREYRVDGLDGFELGGSITVGDFEAGQKVDVSGDTIGRGFSGYQKRHGFSRGPMTHGSKNHREPGSIGPGTTPGRIYPGKRMAGRYGGKKITTRGLTILKVDSERNLLVVKGSVPGKPGALLNIRPALRVGAKPAKGGQ
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: EX7S_CLOBK
Sequence: MGRKKESFENMLEKLETIVDSMDNGEITLEDSMKSYEEGIKLCNKLYKVLKDAEGKIKILEDNKEEDFENS
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YQGF_WOLTR
Sequence: MLYRDPYEFLKSIPKDKCIMCLDMGEKQIGIAFSDKTQLIATAHSVYYRKNISKDLGYLNRIFKKNEAGSIVIGLPLEIDGQKSEWCKTIIKFANKMIKKYKVSTYLQDESLSTSIAAHTLKISGVSTTKSKRIDDKISACIILQRTLDKINVIK
What is the function of this protein?
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
What are the official names of this protein?
Putative pre-16S rRNA nuclease.
What is the protein family that this protein belongs to?
Belongs to the YqgF nuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL9_STRT1
Sequence: MKVIFLQDVKGKGKKGEIKEVPLGYAQNFLIKKNLAKEATKQAIGELKGKQKSEEKHAAELLAEAKRVKEQLEKEENRLQFTEKVGPDGRTFGSITAKKIAEELQKQFGIKIDKRHIELEHPIRAIGLIEVPVKLHKEVNAQIKLNIKNSAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: UBP8_MOUSE
Sequence: MPAVASVPKELYLSSSLKDLNKKTEVKPEKTSTKNYIHSAQKIFKTAEECRLDRDEERAYVLYMKYVAVYNLIKKRPDFKQQQDYYLSILGPANIKKAIEEAERLSESLKLRYEEAEVRKQLEEKDRREEEQLQQQKRQEMGREDSGAAAKRSVENLLDSKTKTQRINGEKSEGAAAAERGAITAKELYTMMMDKNTSLIIMDARKIQDYQHSCILDSLSVPEEAISPGVTASWIEANLSDDSKDTWKKRGSVDYVVLLDWFSSAKDLLLGTTLRSLKDALFKWESKTVLRHEPLVLEGGYENWLLCYPQFTTNAKVTPPPRSRAEEVSVSLDFTYPSLEEPVPSKLPTQMPPPPIETNEKALLVTDQDEKLRLSTQPALAGPGAAPRAEASPIIQPAPATKSVPQVDRTKKPSVKLPEDHRIKSENTDQSGRVLSDRSTKPVFPSPTTMLTDEEKARIHQETALLMEKNKQEKELWDKQQKEQKEKLRREEQERKAGKTQDADERDSTENQHKAKDGQEKKDSKQTKTEDRELSADGAQEATGTQRQSKSEHEASDAKVPVEGKRCPTSEAQKRPADVSPASVSGELNAGKAQREPLTRARSEEMGRIVPGLPLGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKVKPQVPAERDREPSKLKRSYSSPDITQALQEEEKRRPAVTPMVNRENKPPCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNEHLDDLQAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCRRRSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNSLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVRSSAAYILFYTSLGPRITDVAT
What is the function of this protein?
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation.  Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains.  Catalytic activity is enhanced in the M phase.  Involved in cell proliferation.  Required to enter into S phase in response to serum stimulation.  May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1.  Probably regulates the stability of STAM2 and RASGRF1.  Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability.  The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle.  Deubiquitinates EPS15 and controls tyrosine kinase stability.  Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling.  Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.  Deubiquitinates BIRC6/bruce and KIF23/MKLP1 (By similarity).  Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (By similarity).
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 8, Deubiquitinating enzyme 8, Ubiquitin isopeptidase Y, mUBPy, Ubiquitin thioesterase 8, Ubiquitin-specific-processing protease 8.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.
Protein: PA2GA_MOUSE
Sequence: MKVLLLLAASIMAFGSIQVQGNIAQFGEMIRLKTGKRAELSYAFYGCHCGLGGKGSPKDATDRCCVTHDCCYKSLEKSGCGTKLLKYKYSHQGGQITCSANQNSCQKRLCQCDKAAAECFARNKKTYSLKYQFYPNMFCKGKKPKC
What is the function of this protein?
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (PubMed:8425615, PubMed:10358193, PubMed:11694541).  Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines.  Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance.  Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (PubMed:11694541).  Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes.  Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity).  Plays a stem cell regulator role in the intestinal crypt.  Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS).  Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (PubMed:27292189).  May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation.  Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity).  Independent of its catalytic activity, acts as a ligand for integrins.  Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1.  Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1.  Induces cell proliferation in an integrin-dependent manner (By similarity).
What are the official names of this protein?
Phospholipase A2, membrane associated, Enhancing factor, EF, GIIC sPLA2, Group IIA phospholipase A2, Phosphatidylcholine 2-acylhydrolase 2A.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family.
What are the subcellular locations of this protein?
Secreted. Cell membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: TRMHL_STAES
Sequence: MEDIVIVGRHAVKEAIISGHAINKILIQDGIKKQQINDILKNAKSQKLIVQTVPKSKLDFLANAPHQGVAALVAPYEYANFDEFLQKQKKKARYSTVIILDGLEDPHNLGSILRTADASGVDAVIIPKRRSVALTQTVAKASTGAIQHVPVIRVTNLSKTIDELKDNGFWIAGTEANNATDYRDLQADMSLGIVIGSEGQGMSRLVSDKCDFHIKIPMVGHVNSLNASVAASLMMYEVYRKRHQLEEKS
What are the official names of this protein?
Putative TrmH family tRNA/rRNA methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Protein: S29P2_HUMAN
Sequence: MDEERSSMLPTMAAGPNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTLLKESTQGVSSVFREITASSAISILIKPEQETDPLPVVSRNVSADAKCKKERKKKKQVTNIISFDDEEDEQNSGDMFKKTPGAGESSEDNSDHSSVNIMSAFESPFGPNSNGSQSSNSWKIDSLSLNREFGYQKLDVKSIDDEDVDENEDDVYGNSSGRKHRGHSESPEKNGAHSVTQAGVQWHDLSSLQPLPPGFK
What are the official names of this protein?
Putative protein SNX29P2, RUN domain-containing protein 2C, Sorting nexin 29 protein pseudogene 2.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
Protein: RL158_PLAVT
Sequence: MRGAHYVAIVLLVAAGGQTAAGFDQDEPQHAPDNGYMASVDLRNEFLQSRALQASRNPKDDLMFSAGDEERTPLARSNYLKKVTIPDSIINTANAMRMEGKQVRL
What is the function of this protein?
Secreted effector that partially suppresses the host cell death induced by cell death-inducing proteins.
What are the official names of this protein?
Secreted RxLR effector protein 158.
What is the protein family that this protein belongs to?
Belongs to the RxLR effector family.
What are the subcellular locations of this protein?
Secreted. Host nucleus. Host cytoplasm.
Protein: LEXA_BRUME
Sequence: MLTRKQHELLLFIHERLKETGIPPSFDEMKEALDLASKSGIHRLITALEERGFIRRLPNRARALEVLRLPDSIAPGLSPQKKFAPSVIEGSLGKVASVQPVRPAPAPQNSEAPATVSVPVMGRIAAGVPISAIQNQTHMLSLPPEMIGAGEHYALEVKGDSMIDAGIFDGDTIIIKRGDTANPGEIVVALVDEEEATLKRFRREGASIALEAANPAYETRIFGPDRVHVQGKLVGLIRRY
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: TALDO_DROME
Sequence: MGSDRTLKKQKMSVLQELKKITTIVADTGDFEAINIYKPTDATTNPSLILSASSMERYQPLVQKAVEYAKGKKGSVSEQVAEAMDYLCVLFGTEILKVVPGRVSTEIDARLSFDTKKSVEKALKLIALYKSLGVDKERILIKLASTWEGIKAAEILENEHGVHCNLTLLFSFAQAVACAEAGVTLISPFVGRILDWYVANTDTKKFEALKDPGVISVTNIYNYYKKFGYKTLVMGASFRNVGEIKALAGCDLLTISPALLKELENETESVVTYLSVSNAKLQDIEKITVDESRFRWLLNEDAMATDKLSEGIRKFAVDTVKLENLIKTYLK
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Probable transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VANX_STRCO
Sequence: MTGDFAFVDELVSGIRWDAKYATWDNFTGKPVDGYLANRIVGTKALCAALGRAQERAEDLGFGLLLWDGYRPQRAVDCFLRWSQQPEDGRTKARHYPNIGRAEMFDRGYVAARSGHSRGATVDLTLYHLTTGELAAMGGGHDLMDPISHHDARDVPRAEAANRRHLRSIMAACGFASYACEWWHYTLKEEPHPDTYFDFPIA
What is the function of this protein?
Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.  May play a role in immunity or defense against glycopeptide antibiotics (perhaps at a moderate level) in the soil environment.  Might confer vancomycin resistance to S. coelicolor.
What are the official names of this protein?
D-alanyl-D-alanine dipeptidase, D-Ala-D-Ala dipeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M15D family.
Protein: HSPC4_RICFE
Sequence: MFNKLMEVLMSFNLPRIRNKSELQHHTNKQSYVDDVFNNFFNEIASFSYPTHYNNKILSPRTDITENESEYHLEVELPGVTQDNIDLKIDSNILTIDGKKEQSTEKKDHNYHMKERYYGSFSRSISLPSNVDEEHVTANFKDGILSIKIPKKEQSKAKKIKIS
What are the official names of this protein?
Small heat shock protein C4.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
Protein: GCY4_CAEEL
Sequence: MRQLNYYIFISTILTYNLTHGQGPRPVIRVGITAALKTENGSIGWAYTGGAVPLALQYLKSHGYMLNFDFEFHVEYTECDLANTVRAGLNFMKTNNYDVIIGPPCAPALKMMGTLSTIYKKPVLGWGFVSESEISDMNRFPFVASVLPSTKTLGVVTSKLLEIYGWDRVALLYFKNELDYCSSVVNDVEKSLYNESKSVQIVMKAEIDGSNSESTSATLQVVKTRARVILFCAHAGGEKRFYLIQAGLLGMNSSEYVHVMLSMRSVGFGVQTSVGKKPLTLSGLPPIWESFTVNPDGMEDLAKSVAAKMIVIDTSSEVRDKTFLQYMTKNIVYAIREPPLSCKVPECLITNATGMGAYARHLFDVFYMYGMAVSSLNSTDPNVYGNLSLLIPKFTTAFEGMTGEVKLNEDLARKPLYQVYGLNSEYDQISLIDISLINDTVNVVFNYADGNTEVWHFWGGTRPPDTPVCGFLGKSCPLPIFEQYRALVIVAIAVTILILLAIIICMSSKIRNRRVEQSRLHSEWQIHAIKLRLPMHRRASKSSQESETESASETENFTSKSGDTMTSEFKETYTIQYLENDLVLTTAHQVQELSQAEMMKFVKLRKLDHENLNKFIGLSIDGSRFVSVWKMCSRGSLQDIISKGSFSMDYFFMFCMIRDIAEGLHYIHKSFLRHHGNLRSATCLVNDSWQVKLADFGLQFLQDEEEKPFKKNMLWAAPEVIRGSLSIEQMDSSADIYSFAIVASEILTKREAWDLSRRKEGYEEIKYAVKKGGQFVLRPDLHIDIEVNQTLLALVKDCWCENPEERPSAENVCKVLFDMTPNTEDNLMDHVFSMLEEYTSSLEVEVGERTKELTLEKKKSDILLGRMLPKQVAERLKAGQAVEPESFDLVTVFFSDLVKFTDLASKCSPFQVVNLLNDVFSNFDSIIEKHDVYKVESIGDGFLCVSGLPNRNGMEHIRQIVGMSLCFMEFCRNFRIPHLPRERVELRVGINSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLVNNYPYQFETNSRGEVIIKGKGVMETYWLLGKMSLSNQSTPPITKVNHKPRKIASFTDSELTNYSFRSVSPYVENLSDNDDEEIRRVLRREMMRVEV
What is the function of this protein?
Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).  Regulates chemotaxis responses toward Br(1-) and I(1-) salt ions in ASE right (ASER) sensory neuron (PubMed:19523832).
What are the official names of this protein?
Receptor-type guanylate cyclase gcy-4.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: PROA_PROMA
Sequence: MEKQILVPSPTDELVNRALEVKSASVSLSQCSNDQRQSALILMTEALSLRSSEILKANSDDVHRAEQEGLNQALLSRLKLTEEKLRISIEGIRQVASLSDPIGIRQLHRELNTNLYLQRVTVPLGVIGVIFESRPDAVMQIASLAIRSGNGAILKGGSEASLTNIEIVKAMKEGLSKSDIQPESICLLKTRQESLGLLGLDGIVDLIIPRGSNELVRFIQDNTRIPVLGHADGICHLYIDSAVNLNQALDIAIDSKCQYPAACNAIETLLLHKDIAASFLKLAIPAFEKLGVTLLGDELSQSFGIITKAEESDWSTEYLDLKLSVKVVSSVDEAMLHIRRYGSRHTDAIATTNKEIARRFLRTVDSSGVYHNCSTRFADGFRYGFGAEVGISTQTLPPRGPVGLDGLVTYRYFLEGDGHIAEDFSNGKKTFSHIDL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate.  The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
What are the official names of this protein?
Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the gamma-glutamyl phosphate reductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFA2_YEAST
Sequence: MQPITTASTQATQKDKSSEKKDNYIIKGLFWDPACVIA
What is the function of this protein?
The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha).  It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A.
What are the official names of this protein?
Mating hormone A-factor 2.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: SYM_SALTO
Sequence: MLVMSHVLAAVAWPYANGPRHIGHVSGFGVPSDVFARYMRMAGHDVLMVSGTDEHGTPIQVQADAEGVTPRELADRYNRVIVADLHGLGLTYDLFTRTTTGNHYAVVQELFEGMYRNGYIVSKTTMGAISPSTGRTLPDRYIEGTCPICGYESARGDQCDSCGNQLDPIDLRNPKSKINGETPKFVETEHFFLDLPALAGVLGQWLDTREGWRPNVLRFSKNLLDDLQPRAITRDLEWGVPIPLDGWRERGDKRIYVWFDAVIGYLSASIEWARRSGDPQAWRRWWSADGPGKDAPSHYFMGKDNIVFHSVIWPALLAGYSGEGSHDGQPGELGRLNLPTEVVSSEFLTMEGRKFSSSRRVVIYVRDFLERYDADALRYFIAVAGPESNDTDFTWAEFLRRNNDELVAGWGNLVNRSISMAAKNFGAIPPVDPAGLTEADETLLAVARAGFDTVGELIGRHRQKQAIGEAMKVVAEANRYLSEQAPWKLKGEADRPRMGTVLHVALQVVSDANTLLTPFLPHSAQKIHQLLGGTGVHAPMPVIEEVEDLDGGPAYPVLTGDYTVGARWESVPLAVGRALDPPKPVFRKLDPSIVDEELARLAG
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.