PharMolix/UniProtQA huggingface dataset:
Protein: TTI2_MOUSE
Sequence: MKLDSAEEKSGVGCSLPAEGSPPALEPAFSKILNRLSRPKSSGQGGARNAALKDLGALIEAAEGDRFFEGSGSGGSLRGMPEILGQVVRALEKFAAPEEKADGVEEHPEVPEKATEVGSLFLKLLGKVEAAKSSPDCPAWKTGLRHMSGPVYIFAITHRLKQPWTSPASQHVAGEVLSLLLRVTECSSVAGFLCGENEDDRGRFAVVLGLLKPHLNKETWKKNPAVKHVFSWTLQQVTQPWLNQHLEKILPPSLLISDDYQTENKILGVQCLHHIVVTVPAADLLQYNRAQVLYHALFNHLYMPEHHLIQAVLLCLLDLFPVLEKALHWKGDTARVTTHCHEVLQLILTHMEPEHRLLLRRTYARHLPAFVKRLGILTVRHLKRLEQVILGYLEVYDEPEDETRLKILETLKLVMQYTWPRIPCRVVVLLKALLKLICDISRDTIPTTEAAKSTMLQEATDCLILLDHCSQGQVKGLLAKIAVSCEDSTVVSCIRKVQQGSADSPGDDTEGD
What is the function of this protein?
Regulator of the DNA damage response (DDR).  Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins.  The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC).  Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity).
What are the official names of this protein?
TELO2-interacting protein 2.
What is the protein family that this protein belongs to?
Belongs to the TTI2 family.
Protein: TAL_CELJU
Sequence: MTSKLEQLKQFTDVVADTGDIEAIRLYKPLDATTNPSLVYKAAQMPQYQALLDTSINGAKSITNSAEQLSAASDNLAVGIGLEILKLVPGRISTEVDARLSFDTNASIAKARHLISLYEKGGVDKSRVLIKLASTWEGIRAAEILEKEGINCNLTLLFGFNQAAACADAGVFLISPFVGRILDWYKANTNKKEYAAEEDPGVVSVRRIYNYYKQHGYNTVVMGASFRNIGEIEALAGCDRLTISPQLLQELDQDKGELKRVLSPDNRGEAIAKLIDTEASFRFGLNQDAMATEKLAEGIRGFVKDQINLENLLKSRAQ
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_ECO55
Sequence: MTDKIRTLQGRVVSDKMEKSIVVAIERFVKHPIYGKFIKRTTKLHVHDENNECGIGDVVEIRECRPLSKTKSWTLVRVVEKAVL
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: RL11_HAMD5
Sequence: MAKKIQAIVKLQVSAGMANPSPPVGPALGQQGVNIMEFCKAFNAKTEPLEKGLPIPVVITVYADRSFTFETKTVPAAVLLLKAAGVKSGSPKPNTNKIGKVTKTQVREIAETKQADMTGTSIDANIQSILGTARSMGLEVEE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: NHAA_PARD8
Sequence: MDRTINVILKPLRRFAIQKPNASLLLFAATIVAMVLANSPWADRYHQLLAFPIDLQAGQFNFFAHHGETMSMLAFVNDALMAVFFFVIGLEIKQEVLIGELSSVRKALLPIIAACGGMIVPVLFYMLVCNTPPEVNGAAIPMATDIAFALAVLGLLGKRVPLSMRIFLTALAVVDDIGGIIIIALFYSGHIAFEPLLISLIVLALLYVGGKFRVHNRLFFYIGGFIVWLLFLESGIHPTIAGVLIAFTVPARPVVKLDDFTCDMTGYLNMLDYTEVRQSRKAEVLTPTQIQVLNNIHTLADKTISPLQTIADKLHPLVNYVILPLFAFVNAGVTFGDIQPQTLVNVPLAVFVGLFVGKTLGIFSFSYLFACTPFASMPTGMSKRNLFGVSMLGGIGFTVALFIANLSFDGSTAAGADLLNQAKLGVFTGSFISGLCGYLVLKWVLPKEKVETI
What is the function of this protein?
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
What are the official names of this protein?
Na(+)/H(+) antiporter NhaA, Sodium/proton antiporter NhaA.
What is the protein family that this protein belongs to?
Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUSB_AGRRK
Sequence: MSNQDNERPAKTANQRGAARLAAVQALYQMDIGGTGVLEVVAEYEAHRLGQELDGDTYLKADASWFRSIVSGVVREQTRLDPLIGSALQDDWALSRLDSTVRAILRAGTFEILDRKDVPVAVIVTEYVEIAHAFFDDDEPKLVNAVLDRIAKQVRGEAKK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: PLRG1_HUMAN
Sequence: MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPTSKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSESAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346).  Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257).  As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
What are the official names of this protein?
Pleiotropic regulator 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PRL1/PRL2 family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: AMN1_CANGA
Sequence: MVLPDSNIMKNGSIKRLRDSQIENSPYSRPIKKITPNSSHEDLSATISNEGSLNFTPRTSRQESLYNMKKIFQKTYSQTKLGLFSSKKQVNTLETAIPTTPKQQLPTPTTSPEKNNILWSTPNSLTSLRTISNDLDDCRNRNLITDFSELSIINSSSSSIYSTQQSHPIFEIPEIVDNIVKQLYLIENEQDLLNGHHKKDVNRENTSTVVSCLAVSKTWNKVSKGYLMRDLKFTKSTSLTNFLSQCSTKKTTPQSLILHKMSDINNNNSRGLEIIIDPKQLRHLEYYVCPNILPPVNWFQSLTKLEKLILPGNKLINDSYLIQICRYLPNLKVLDLRACDNITDAGIVAVGTHCKQLVSCNIGRHRNGSSITGLSVVALAKNTMIRTLGLAGCDITDASMWELAQKCGKNIERLSLNNCNKLTNFSLPMLFAFNYFPNLNVLEIQNIAKITDVRHMVRYKIWKRSQRIPILIKGCDRITKLIHEEERQIKAQSLKTARKDMTLWVNQLENE
What is the function of this protein?
Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints.  Required for daughter cell separation and chromosome stability.  Involved in copper sensitivity.
What are the official names of this protein?
Antagonist of mitotic exit network protein 1.
What is the protein family that this protein belongs to?
Belongs to the AMN1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PURQ_THEVB
Sequence: MSEGLNVGIVVFPGSNCDRDVAYVTREILQWPTQLLWHEETDLGDYDLIVLPGGFSFGDYLRCGAIARFSPIMAAVKDHAAAGKWVLGICNGFQILTEAKLLPGALVRNRDLHFICDRVHLRLEAKERPWLRAYGDKTVIRLPIAHGEGCYYADATTLAELEANRQVLFRYADAQGNVTPESNPNGSLNNIAGICNAAGNVLGMMPHPERAADPALSHSPSEHTLDGLQLFQSLLLASAFA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurQ, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRH_SYNJA
Sequence: MKYRRILLKLSGEALMGERPYGIDPEVLQSIASEVASVVRAGVQVAIVVGGGNIWRGRKEAAAQGMDQASADYVGMLATVINALTLQDAIERAGIPTRVQTAIAMQEVAEPYIRRRAIRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDAEVIFKATKVDGVYDADPKTHPQARRYDVLSYQDVLTRDLRVMDSTAIALCKENQLPIVVFDLTTPGNIYRVVQGEPIGTWIGQTTPKSNGIPARLAQESGS
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PRX2_PENRO
Sequence: MATSTETISSLAQPFVHLENPINSPLVKETIRPRNDTTITPPPTQWSYLCHPRVKEVQDEVDGYFLENWKFPSFKAVRTFLDAKFSEVTCLYFPLALDDRIHFACRLLTVLFLIDDVLEHMSFADGEAYNNRLIPISRGDVLPDRTKPEEFILYDLWESMRAHDAELANEVLEPTFVFMRAQTDRARLSIHELGHYLEYREKDVGKALLSALMRFSMGLRLSADELQDMKALEANCAKQLSVVNDIYSYDKEEEASRTGHKEGAFLCSAVKVLAEESKLGIPATKRVLWSMTREWETVHDEIVAEKIASPDGCSEAAKAYMKGLEYQMSGNEQWSKTTRRYN
What is the function of this protein?
Aristolochene synthase; part of the gene cluster that mediates the biosynthesis of PR-toxin, a bicyclic sesquiterpene belonging to the eremophilane class and acting as a mycotoxin (PubMed:24239699, PubMed:27921136).  The first step of the pathway is catalyzed by the aristolochene synthase which performs the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene (PubMed:8440737, PubMed:15186158, PubMed:24239699).  Following the formation of aristolochene, the non-oxygenated aristolochene is converted to the trioxygenated intermediate eremofortin B, via 7-epi-neopetasone (PubMed:24239699, PubMed:26274339).  This conversion appears to involve three enzymes, a hydroxysterol oxidase-like enzyme, the quinone-oxidase prx3 that forms the quinone-type-structure in the bicyclic nucleus of aristolochene with the C8-oxo group and the C-3 hydroxyl group, and the P450 monooxygenase ORF6 that introduces the epoxide at the double bond between carbons 1 and 2 (PubMed:24239699, PubMed:27921136).  No monoxy or dioxy-intermediates have been reported to be released to the broth, so these three early oxidative reactions may be coupled together (PubMed:24239699).  Eremofortin B is further oxidized by another P450 monooxygenase, that introduces a second epoxide between carbons 7 and 11 prior to acetylation to eremofortin A by the acetyltransferase ORF8 (PubMed:16345540, PubMed:24239699, PubMed:27921136).  The second epoxidation may be performed by a second P450 monooxygenase (PubMed:24239699).  After the acetylation step, the conversion of eremofortin A to eremofortin C and then to PR-toxin requires only two enzymes (PubMed:24239699).  First the conversion of eremofortin A to eremofortin C proceeds by oxidation of the side chain of the molecule at C-12 and is catalyzed by the short-chain oxidoreductase prx1 (PubMed:16345540, PubMed:24239699).  The cytochrome P450 monooxygenase ORF5 also plays a role in this step (PubMed:27921136).  The primary alcohol formed at C-12 is finally oxidized by the short-chain alcohol dehydrogenase prx4 that forms PR-toxin (PubMed:16345540, PubMed:24239699).
What are the official names of this protein?
Aristolochene synthase, AS, PR-toxin biosynthesis protein 2, Sesquiterpene cyclase.
What is the protein family that this protein belongs to?
Belongs to the terpene synthase family.
Protein: RGS20_HUMAN
Sequence: MPQLSQDNQECLQKHFSRPSIWTQFLPLFRAQRYNTDIHQITENEGDLRAVPDIKSFPPAQLPDSPAAPKLFGLLSSPLSSLARFFSHLLRRPPPEAPRRRLDFSPLLPALPAARLSRGHEELPGRLSLLLGAALALPGRPSGGRPLRPPHPVAKPREEDATAGQSSPMPQMGSERMEMRKRQMPAAQDTPGAAPGQPGAGSRGSNACCFCWCCCCSCSCLTVRNQEDQRPTIASHELRADLPTWEESPAPTLEEVNAWAQSFDKLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKNIIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMVEPSQHIFDDAQLQIYTLMHRDSYPRFMNSAVYKDLLQSLSEKSIEA
What is the function of this protein?
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.  Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities.  The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein.  Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
What are the official names of this protein?
Regulator of G-protein signaling 20, RGS20, Gz-selective GTPase-activating protein, G(z)GAP, Gz-GAP, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1.
What are the subcellular locations of this protein?
Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation.
Protein: SYGB_GEOMG
Sequence: MKELFLEIGTEEIPAGFIPKAMADMEALLAKELENARISFDDIRTLGTPRRLALTVKGLPTVQPDAEITAMGPARNVAFDAEGKPTRAAEGFARGQGVDVASLTLVATEKGEYVAAVRKESGRPVPELLAEILPRLVANIPFRKSMRWGALDVRFARPIHWIVALFDGVVVPFTFGNIESGTISRGHRFMANQPFPVRDFAHYLEECERHFVIPDPERRQEIIRREIHRVAKAAGGHLLPDEGLLEEVSFLCEYPSAVHGTFSAEFLKVPREVLITSMRSHQRYFSIVDDAGKLMPGFITINNTLTEDPTVVVKGNERVLRARLSDARFFFEEDQKVKLETRVESLKNVVYQQKLGTSFEKMERFRALAEGLADLLNPAVKVKVSQAAFLCKADLVSGMVGEFPEVQGIMGREYALIEGEDAEVAAAIAEHYLPTQAGGELPASDIGAFVSMADKLDTICGCFGVGLIPTGSADPYALRRSALGIINIILDKGYRLSLEEQVDKALGLLAAKLTRPAVDVKADVLEFFRGRFVNLMADRHASDAVDAAVAAGCADLVDAAARIAALSEFRSHPDFEPLAVAFKRVGNIVKEGVDAPVDTALFQDAAEGLLNDAVQGVAVSVREKIATGAYLEALTEIAALRGPVDTFFDKVMVMAEDERVRTNRLALLTGIARMLGAIADFAKIAA
What are the official names of this protein?
Glycine--tRNA ligase beta subunit, Glycyl-tRNA synthetase beta subunit, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THIE_DESHY
Sequence: MAVDYSLYLVTDRILVGPKDFLLSIRKALEGGVTLLQLREKETNSREFYDIGVKVKELAAEFGVPLIINDRVDLALALDADGVHVGQQDLPLAKVRNIIGPDKILGYSVSSLEEALQGERMGADYLGAGPVFPTGSKKDAAEAIGLAKLKEIKAGVSLPVVGIGGIGAANLRAVKETGIDGVSVISAILSQEDPCAAAKGLMDLWRN
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: BASP1_HUMAN
Sequence: MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE
What are the official names of this protein?
Brain acid soluble protein 1, 22 kDa neuronal tissue-enriched acidic protein, Neuronal axonal membrane protein NAP-22.
What is the protein family that this protein belongs to?
Belongs to the BASP1 family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor. Cell projection, growth cone. Note=Associated with the membranes of growth cones that form the tips of elongating axons.
Protein: SYP_SALTI
Sequence: MRTSQYLLSTLKETPADAEVISHQLMLRAGMIRKLASGLYTWLPTGLRVLKKVENIVREEMNNAGAIEVSMPVVQPADLWQESGRWEQYGPELLRFVDRGERPFVLGPTHEEVITDLVRNELSSYKQLPLNFFQIQTKFRDEVRPRFGVMRSREFLMKDAYSFHTSQESLQETYDAMYAAYSRIFSRMGLDFRAVQADTGSIGGNASHEFQVLAQSGEDDIVFSDVSDYAANIELAEAIAPQTPRAAATQEMTLVDTPNAKTIAELVEQFNLPIEKTVKTLLVKAVKDSKSPLVALLVRGDHELNEVKAEKLPHVASPLTFATEEEIRAVINAGPGSLGPVNMPIPVIIDRTVAAMSDFAAGANIDGKHYFGINWDRDVATPVVADIRNVVAGDPSPDGQGTLLIKRGIEVGHIFQLGTKYSEALKASVQGEDGRNQILTMGCYGIGVTRVVAAAIEQNFDERGIVWPDAIAPFQVAILPMNMHKSFRVQELAEKLYSELRAQGIEVLMDDRKERPGVMFADMELIGIPHTIVIGDRNLDNDDIEYKYRRSGEKSLIKTGDIVDYLVKAIKG
What is the function of this protein?
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).  As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine.  One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro).  The misacylated Cys-tRNA(Pro) is not edited by ProRS.
What are the official names of this protein?
Proline--tRNA ligase, Prolyl-tRNA synthetase, ProRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CYB_POTPR
Sequence: MTNIRKSHPLMKIINNAFIDLPAPSNISSWWNFGSLLGICLIFQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWVIRYLHANGASMFFICLFIHVGRGLYYGSYMFLETWNIGVILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVITALAVVHLLFLHETGSNNPTGISSDMDKIPFHPYYTLKDILGALFMMLILLILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVASILILILMPMLHTSKQRSMMFRPLSQCLFWMLVADLITLTWIGGQPVEHPFIIIGQLASILYFLIILVLMPITSIIENNLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: GLGC_SALCH
Sequence: MVSLEKNDRVMLARQLPLKSVALILAGGRGTRLKDLTNKRAKPAVHFGGKFRIIDFALSNCLNSGIRRIGVITQYQSHTLVQHIQRGWSLFSEEMNEFVDLLPAQQRMKGENWYRGTADAVTQNLDIIRRYKAEYVVILAGDHIYKQDYSRMLIDHVEKGARCTVACMPVPIKEATAFGVMAVDESDKIIDFVEKPANPPAMPGDASKALASMGIYVFDADYLYELLAADDKDDASSHDFGKDIIPKITREGMAYAHPFPLSCVQSDPQAEPYWRDVGTLEAYWKANLDLASVTPELDMYDQNWPIRTHMESLPPAKFVQDRSGSHGMTLNSLVSGGCIISGSVVVQSVLFPRVRINSFCNIDSAVLLPEVWVGRSCRLRRCVIDRACIIPEGMVIGENAEEDARRFYRSEEGIVLVTREMLRKLQVKQER
What is the function of this protein?
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen.  Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
What are the official names of this protein?
Glucose-1-phosphate adenylyltransferase, ADP-glucose pyrophosphorylase, ADPGlc PPase, ADP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
Protein: VDAC1_RABIT
Sequence: MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVTGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDVDFDIAGPSIRGALVLGYEGWLAGYQMNFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA
What is the function of this protein?
Forms a channel through the mitochondrial outer membrane and also the plasma membrane.  The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis.  It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV.  The open state has a weak anion selectivity whereas the closed state is cation-selective.  Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol.  In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis.  May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.  May mediate ATP export from cells.
What are the official names of this protein?
Voltage-dependent anion-selective channel protein 1, VDAC-1, Outer mitochondrial membrane protein porin 1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic mitochondrial porin family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
Protein: ATPF_LEUMM
Sequence: MLGITTLAALPLGNMLFIIIAFLLLMLILKKVAYGPLTKVLDERADKISSDIDGAEVARQEAEKLASQRQAELAETRQNATKVVNDAKASAQKQSDLIVSAANDRAASVSQQAQTDAQKLKEDAISGAKNDVAALSVAIASKLMQKELSLNDQQALIDAYISDLETK
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: AK1A1_MOUSE
Sequence: MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols.  Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity) (PubMed:22820017, PubMed:15769935, PubMed:20410296).  Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (PubMed:20410296, PubMed:15769935, PubMed:22820017).  Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes.  Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity).  Involved in the detoxification of lipid-derived aldehydes like acrolein (By similarity).  Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).  Displays no reductase activity towards retinoids (By similarity).
What are the official names of this protein?
Aldo-keto reductase family 1 member A1, Alcohol dehydrogenase [NADP(+)], Aldehyde reductase, Glucuronate reductase, Glucuronolactone reductase.
What is the protein family that this protein belongs to?
Belongs to the aldo/keto reductase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Apical cell membrane.