PharMolix/UniProtQA huggingface dataset:
Protein: IF4A_LEIMA
Sequence: MAQNDKIAPQDQDSFLDDQPGVRPIPSFDDMPLHQNLLRGIYSYGFEKPSSIQQRAIAPFTRGGDIIAQAQSGTGKTGAFSIGLLQRLDFRHNLIQGLVLSPTRELALQTAEVISRIGEFLSNSSKFCETFVGGTRVQDDLRKLQAGVIVAVGTPGRVSDVIKRGALRTESLRVLVLDEADEMLSQGFADQIYEIFRFLPKDIQVALFSATMPEEVLELTKKFMRDPVRILVKRESLTLEGIKQFFIAVEEEHKLDTLMDLYETVSIAQSVIFANTRRKVDWIAEKLNQSNHTVSSMHAEMPKSDRERVMNTFRSGSSRVLVTTDLVARGIDVHHVNIVINFDLPTNKENYLHRIGRGGRYGRKGVAINFVTEKDVELLHEIEAHYHTQIDELPVDFAAYLGE
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
Probable eukaryotic initiation factor 4A, eIF-4A, ATP-dependent RNA helicase eIF4A.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein: Y1243_ZYMMO
Sequence: MRHLITISQPAIPQDVTNKDGHKAKKQLRCKGIYPFLWMFFFAAALPLQATQPIEVTRFHKSDMATTGIVNIMPHDPTLRNTLEYQRYTASIARNLTRIGFQVTDNPQQAEYTMMYDVMRGTHYRDNGQTPPRDTRPHGGISLGGGYGGGGGFGGGGVGWGGGGSGISIGGGGGGGRGFGGGGGGISAGISVPVGNGYHTSNKVETILTAQLSRRDTHQAIWEGRARTEAKSNKAESTPDIAVDRLATAMFGQFPGESGETEKVK
What are the official names of this protein?
Uncharacterized protein ZMO1243.
Protein: PAPIL_HALPP
Sequence: GFWKKVGSAAWGGVKAAAKGAAVGGLNALAKHIQ
What is the function of this protein?
Has strong antibacterial activity against the Gram-positive bacteria M. luteus, S. aureus, B. megaterium, A. viridans and E. faecalis, and against the Gram-negative bacteria K. pneumoniae, E. coli DH5alpha, S. typhimurium, P. aeruginosa and E. aerogenes.  Lacks hemolytic activity against sheep erythrocytes.
What are the official names of this protein?
Papillosin.
Protein: YEAH_ECODH
Sequence: MTWFIDRRLNGKNKSMVNRQRFLRRYKAQIKQSISEAINKRSVTDVDSGESVSIPTEDISEPMFHQGRGGLRHRVHPGNDHFVQNDRIERPQGGGGGSGSGQGQASQDGEGQDEFVFQISKDEYLDLLFEDLALPNLKQNQQRQLTEYKTHRAGYTANGVPANISVVRSLQNSLARRTAMTAGKRRELHALEENLAIISNSEPAQLLEEERLRKEIAELRAKIERVPFIDTFDLRYKNYEKRPDPSSQAVMFCLMDVSGSMDQSTKDMAKRFYILLYLFLSRTYKNVEVVYIRHHTQAKEVDEHEFFYSQETGGTIVSSALKLMDEVVKERYNPAQWNIYAAQASDGDNWADDSPLCHEILAKKLLPVVRYYSYIEITRRAHQTLWREYEHLQSTFDNFAMQHIRDQDDIYPVFRELFHKQNATAKG
What are the official names of this protein?
UPF0229 protein YeaH.
What is the protein family that this protein belongs to?
Belongs to the UPF0229 family.
Protein: PUP_KINRD
Sequence: MSGHEQQRPSRREEDVEETPVVPAQAGAQAKESDADVDALLDEIDEVLESNSEEFVRGFVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: CH605_BRADU
Sequence: MAHKQVLFHSAAREKILRGASLLADAVRVTLGPKSKSVLIQKGWGAPIVCNDGVTIAKEFDLKDAEENLGAQVLRQLAEKTGDVVGDGTSTSTILAHAILSDGVRNVVAGASAIDLKRGLDRGTQAAIAALRAMATPVKSRAEKVQVATISAHNDASIGELVADAIEKVGGDGVISVEESKTTETLLDVVEGMKFDRGFLSPYFITDADRMESVLQDPYVLLCDHKIGALRDLVPLLEQVAKSGQPLLIIAEDIEGEALATLIVNQLRGVLKACAVKAPGFGDRRKAMLEDIAILTGAQVISEEIGLNLENATLQQLGRAARVVADKENTTLIGSGGDRTRIDARLGQIRVEIEKTTSDYDREKLEERLAKLSGGVAVIRVGAPTEAEMKAKKEALDDAISSTKAAVAEGIVPGGGLALLRAVAAVAKEEAACEGDERTGVQILRRALEAPARQIAENSAADGGVVVARMLEGEGSIGFDASRKVYVDLVAAGIVDPVKVVRTALENAVSVASVLLLTEATMTEIPEPKRERLPEPDLAVQ
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 5, 60 kDa chaperonin 5, Chaperonin-60 5, Cpn60 5.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHLL_TRIEI
Sequence: MKLSVYGKGGIGKSTTSCNISVALAKRGKKVLQIGCDPKHDSTFTLTGFLIPTIIDTLQEKDYHYEDIWPEDVIYKGYGGVDCVEAGGPPAGAGCGGYVVGETVKLLKELNAFDEYDVILFDVLGDVVCGGFAAPLNYSDYCMIVTDNGFDALFAANRIAASVREKARTHTLRLAGLIGNRTSKRDLINKYVEAVPMPVLEVLPLIEDIRVSRVKGKTLFEMAETDPSLQYVCNYYLNIADQILALPEGVVPSESPDRDLFALLSDFYLNPSKSHVMSEDEELDLMMV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
What are the official names of this protein?
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein, DPOR subunit L, LI-POR subunit L.
What is the protein family that this protein belongs to?
Belongs to the NifH/BchL/ChlL family.
Protein: Y4279_DICDI
Sequence: MYKLATLEFIKKAKTLKLLSQKTQTTSKIQTFSSIKLLI
What are the official names of this protein?
Putative uncharacterized protein DDB_G0292228.
Protein: DNLJ_FRAT1
Sequence: MTPNEFFSIKYHILAKAELKAYIDKLADYLSQQSYLYHTLDKPIISDSDYDKLFRLLQDLVNDNPQFKPINSVLDRVGGEVLAGFETIKHKKKMTSLANVFSLEELRDFYDKIEYDIELECEPKMDGLAISIFYKNGKFDYAVTRGDGIQGEKVSENVKTIRNVPLKLNTSNPPEELEVRGEIILDKQSFLSLNEYMQTHENKTFANPRNAAAGSIRMLDSKVVAKRPLKLYSYGIGYFSKDFVYPETQFELMQLLQSFGFTISDNMFLAKNFSEVEEYHHKMSHQRADLAYDIDGLVFKVNNIKLQDTIGYTARGPKWAIAYKFPAEEVESEVLNVEFQVGRTGAITPVARLKPVAVGGVIVSNATLHNINEIKRKDIRVGDRVIVRRAGDVIPEVVKSLPQYRKSDAQMVEMPTNCPVCDSKIENVNDQAIYRCTGGWHCQAQTTERLKHFVSRKAMDIDKLGAKLIEQLVAANLIKYPADIYKLNFEQLTGLERMAAKSSQNVLDSITKSKEPSLARFIFAIGIKDIGEVSSDALANHFGSLESFRDAKFEELIEINDIGEIMANNIVSFWHDSLNIKIVEEFLAIGIKIQNPVKVEHAYNESFTGKTVVITGSFENYGRTELTQLLKSIGAKVTSSVSKKTDMVICGDNAGSKLTKAQELGVEVILEDNLKDLL
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: FLGA2_HALVD
Sequence: MFNNITDDDRGQVGIGTLIVFIAMVLVAAIAAGVLVNTAGFLQATAEDAGEQSVNKVTNRVEVLNTHGTVGGEEDIDNITLTVRLAAGSDAVDMNETSIKYLSGDSVVTLTNQTVTSGANSATNDSAEGVADSDEFGLSEVTDDDGSFGVLNSMNDRYEVTIDTAAIETSDGDNTNLIGGLSTGEQVTLEITSRTGGTTQVILTMPQQLAGKTQNEPVEL
What is the function of this protein?
Flagellin that plays both structural and regulatory roles in flagella biosynthesis.  Does not constitute a major flagellin in terms of abundance contrary to FlgA1: may regulate the flagella-dependent swimming motility depending on the relative abundance of FlgA1.  Not involved in PibD-dependent surface adhesion.
What are the official names of this protein?
Flagellin A2.
What is the protein family that this protein belongs to?
Belongs to the archaeal flagellin family.
What are the subcellular locations of this protein?
Archaeal flagellum.
Protein: PH3H_STRC4
Sequence: MQGPHAQMTDAAYEIRRSEIAALSTDLAPEDPIPVVEYTEWEHEVWRTVCVDLTARHRTDAAAEYLESAEQLAVPLDHVPQLRDVSGRLGSISGFTFQSAPALVPLREFCGGLANSVFHSTQYLRHPRSPFYTEDPDLLHDLVGHGNVLASDRFARLYRLAGNAAARVHSTEALQFIGKVFWFTLECGVVRERGERKAYGATLVSSYGELDHFRSADFRPLDIKSLADVEYDISTYQPILFEADSMDEVEDTVGSFWDTCDDDSIAALLGGTSRSVTPH
What is the function of this protein?
In vitro, catalyzes the highly regiospecific C-3 hydroxylation of L-phenylalanine (L-Phe) to yield 3-hydroxy-L-phenylalanine (meta-Tyr), an amino acid found in bacterial secondary metabolites such as sanglifehrin A and some pacidamycins.  Tetrahydrobiopterin (BH4) seems to be the physiological pterin, however the hydroxylase is also able to use 6-methyltetrahydropterin (6-MePH4).
What are the official names of this protein?
Phenylalanine 3-hydroxylase, Phe3H, Fe-dependent phenylalanine hydroxylase, Phenylalanine 3-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Protein: HSL64_DICDI
Sequence: MTLFSSISSMSSSMTSSKSSFASFGNGTRVSSNSIACSVDCDGKGVSSGSDLTGGAKSGGDCGGKGRPNNHGHGHENCHGGKGPGNSC
What are the official names of this protein?
HssA/B-like protein 64.
What is the protein family that this protein belongs to?
Belongs to the hssA/B family.
Protein: ILVD_RUEPO
Sequence: MPMYRSRTSTHGRNMAGARGLWRATGMTDGDFGKPIIAIVNSFTQFVPGHVHLKDLGQMVAREVEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREVIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAIFVSGGPMEAGKIDIADLEMTKIDLVDAMVAAANDKFTDEQVQHIEENACPTCGSCSGMFTANSMNCLAEALGLALPGNGSTLATHSDRKALFLEAGRRIVEITKRHYEGEEKGLLPREIATFEAFENAMSLDIAMGGSTNTVLHLLAIAHEGEVDFTMTDMDRLSRKVPCLCKVAPNTANVHMEDVHRAGGIFSILGELSRAGLLHDDCGTVHSASMGEAIAKWDIKVANNPEAESLFKAAPGGVRTTQAFSQSNRYKDLDTDREGGVIRSKEHAFSQDGGLAVLFGNIAEDGCIVKTAGVDASILQFTGTAHVCESQDDAVNNILTGKVKEGDVVVIRYEGPRGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVEDGDRIEIDIPNRRIHLAVSDEVLAARRAAQEAKGWHPAKPRKRKVSTALKAYAKLTTSAAKGAVRQV
What is the function of this protein?
Functions in the biosynthesis of branched-chain amino acids.  Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
What are the official names of this protein?
Dihydroxy-acid dehydratase, DAD.
What is the protein family that this protein belongs to?
Belongs to the IlvD/Edd family.
Protein: CYB_MYZSE
Sequence: MNLKHPTRKDHILIKVVNNLLIDLPTPSNLSIMWNWGSLLGIFLIIPIITGLFLAMHYTPHMNLAFESIYHIMYDVNMGWLIRFIHVNGASFFFIFLYLHMARGMYYYSFHYKEVWLIGCTIYVVSMATAFMGYILPWGQMSLWGATVITNMLTTIPYLGQYLVQWIWGGFAVGNPTLNRFFVLHFILPFIILALSIIHLIFLHSKGSTNPLGMNSNAYKIPFHPYYSSKDLMFLLLLMMIMMVIIFWNPFLFMDAENSLEANFMKTPVHIKPEWYFLWVYTLLRSIPNKLGGVLTMVFSILILFLLPFISNFNYITSMSMINKLLFWSFVVNMLILTWIGGMPVVPLFETMGLTSTFLYFIIILIYSNSFLMINKS
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: TLE4_XENLA
Sequence: MIRDLSKMYPQTRHPAPPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHAHGLPVPLTPHPSGLQPPAIPSIGSSAGLLALSSALGGQSHLPIKDEKKHHDSDHQRDRDSIKSSSVSPSASFRAAEKHRNSTDYSSESKKQKTEEKDIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKPRLLKKDAPISPASIASSSSTPSSKSKEHSHNEKSTTPVSKSNTPTPRTDAPTPGSNSSGLRPVPGKPPGVDPLTGLRTPMAVPCPYPTPFGIVPHAGMNGDLTSPGPAYASLHSISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPGIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
What is the function of this protein?
Transcriptional corepressor.  Functions with ripply2. 2/bowline to down regulate transcription of tbx6-dependent gene expression.  Represses transcription of siamois and nodal3.
What are the official names of this protein?
Transducin-like enhancer protein 4, Enhancer of split groucho-like protein 2, ESG2, xESG2, Grg-4, XGrg-4, Groucho-related protein 4.
What is the protein family that this protein belongs to?
Belongs to the WD repeat Groucho/TLE family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MTAL3_KLULA
Sequence: MAQVDVTRWVIHPSGSYESETRKRKLREEKRRKLNEIKRASLVLNDSDFKNFEHWLVTSKGVGEYEQVFDFNFDAYTTRGKPAVDSSTSYSDNIFIDGDKNCKIDTKTISFLDRKYQSNNQTKIESEKQMHVITLKNEQLIEECKNIRERLLELIREGTGYIFVRGWTGYRVNTIILKCHCKQDKCHQILKPRCNVKKHHDPDNLKQFNCFSSFSVHFNVKLNTIKICFCHKSKHETLPITIIPASLRQYISTNLCFTARECFECLKRTPVYLEFTKSFDAKAIVRKIWKEISESQWNLDPDSKRSASKILKRFQNTGDVALLPVDNCSADLNISLQKAKPIAFIYERIISEIQHDVTEIVIDSTFCLSTDYKQYFVVVASFFGKGVPVGFMATETNNVDHLTILWFLRSVLQKLPKVKCINSDWSLAEIKAINLLKCSNQICLFHTLTAIRCKRLASKKNMTESLFHQQFQSLLNYEWVDDNIFDPTRYEEKYQEKVSEYQIREIVRLVRIAICDHILLHSAGLNKVFQDSDSENVKVLKLYEYHLKQLYVITVQKFSLPCYFCYLFNQYYNFTSFQIMSRVGKPTFFSVLRTSMMCESYFNQLKSWNLSGSRNYRFDTLIYILLNKEVAKIKESIRITKKFEKEYDSNCLVQNHRKHLPTWRKQWIIEWKNILQELNCLQEKDVFNECQQYGTNMTTWICGCNDAKVSPSSTCIHLVSLYKQKFPFYHGYTLQRFGKRNNGVPLVQHESLQSDTKIESTENMSFEISDVTINGVCNTTKQMSDANCRKLDYETEIDMISENKHSEIDDESEGKLRIFNFFLADEETRLLITQCPSFKSIIEEMTYIKQRTQSEPQWKAKTNKPEKGFKYDSWIRCLKYYQCYADVKANGNFPLPF
What is the function of this protein?
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion.  Required for efficient mating as an alpha-cell.
What are the official names of this protein?
Mating-type protein ALPHA3, Protein MAT-alpha-3, Protein HML-alpha-3.
Protein: ASSY_BUCAT
Sequence: MIRKKNNKVVLAYSGGLDTSAIIPWLKENYNFEVVAFVADIGQSKKDLNGIEKKSLESGASSCHVFDLKEEFIENYVYPVLKTGALYEGSYLLGTAMARPIIAKKQVELALNIGANSLCHGATGKGNDQVRFEMAYAALAPNLNVIAPWREWNLNSRESLLKYLDKKNISTTATLEKIYSKDENSWHISTEGGLLENPWNQSNEDCWSWTVNPEDAPEKPEYVSLQLKEGCVVSVNNQKLNPLKCVEELNSLGAKHGIGRIDIIENRLIGMKSRGCYETPGGTIIMTAIKAIEQLVLDRESFRWREKIGLEMSSIVYDGRWFSPIRKSLQAAADSLSLEITGEVILKLYKGSVTAVQKKSPNSLYSEEYATFGEDKVYKQSDADGFIRLFSLSSKIRAQNMLK
What are the official names of this protein?
Argininosuccinate synthase, Citrulline--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the argininosuccinate synthase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD_OCEIH
Sequence: MATLLNGKELSEELKQKMKIEVDELKEKGLTPHLTVILVGDNPASKSYVKGKEKACAVTGISSNLIELPENISQDELLQIIDEQNNDDSVHGILVQLPLPDQMDEQKIIHAISPAKDVDGFHPINVGKMMTGEDTFIPCTPYGILTMLRSKDISLEGKHAVIIGRSNIVGKPIGLLLLQENATVTYTHSRTKNLQEITKQADILIVAIGRAHAINADYIKEDAVVIDVGINRKDDGKLTGDVDFESAEQKASYITPVPRGVGPMTITMLLKNTIKAAKGLNDVER
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: THIM_METVS
Sequence: MKFIAENLTKLRTISPLVQNITNYVVMNSTANTLLALGASPVMAHAKEELEEMIAISSALVVNIGTLDEYWIPSMEKAVKIASDLKKPIILDPVGAGATKLRTNTALKLLDIGNVSVLRGNFGEISALLGEHGKTKGVDSAVYDNNEALNISKNASKEFNTVSTVTGPIDYVSNGKEIYSISNGHEMLSKVTGTGCASTSIIGAFLAVEEPLKASVSGLVTYGISAEMAFEESFYPGTFQAKLYDWLYRIDEKLILEKAKVNRIDI
What is the function of this protein?
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
What are the official names of this protein?
Hydroxyethylthiazole kinase, 4-methyl-5-beta-hydroxyethylthiazole kinase, TH kinase, Thz kinase.
What is the protein family that this protein belongs to?
Belongs to the Thz kinase family.
Protein: PA2HF_TRIST
Sequence: MRTLWIMAVLLVGVEGGVIELTKMFVQEMGKNALTSYSLYGCNCGPGGRRKPMDATDSCCHVHKCCYKKLTDCDPIKDRYSYSWVNKAIVCGEDNPCLKEMCECDKAVAIRFRENLDTYDKKKKINLKLFCKKTSEQC
What is the function of this protein?
Snake venom phospholipase A2 homolog that lacks catalytic activity (PubMed:12959640).  It shows myotoxic and weak anticoagulant activities (PubMed:12959640).  A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e. g.  fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity).  This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity).  The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity).  Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity).  This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i. e.  calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity).
What are the official names of this protein?
Basic phospholipase A2 homolog Ts-K49b, svPLA2 homolog.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily. K49 sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SECG_MYCBO
Sequence: MELALQITLIVTSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSGSTVVEKNLDRLTLFVTGIWLVSIIGVALLIKYR
What is the function of this protein?
Involved in protein export.  Participates in an early event of protein translocation (By similarity).
What are the official names of this protein?
Probable protein-export membrane protein SecG.
What is the protein family that this protein belongs to?
Belongs to the SecG family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RBSD_LACGA
Sequence: MKKTGVMNSNISRVIADMGHMDWLGVGDAGTPVPAETEKIDLSVRPGLPSFIDVLEEVLKELEVQKIYIAEEIKTENPKQLEAIKKTLPNVEIEFIPHSELKKDLKTSKAFIRTGEETPYSNVILESGVTF
What is the function of this protein?
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
What are the official names of this protein?
D-ribose pyranase.
What is the protein family that this protein belongs to?
Belongs to the RbsD / FucU family. RbsD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SH3R1_BOVIN
Sequence: MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEQLPSNILLVRLLDGIKQRPWKPGPVGGSGTNGTSALRAQSSAVVTCSPKDGPSSQGGPQPRAQAWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIVLRRQVDENWYHGEVGGVHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDQPPGPGVAAGEGALATTPSSTTTKQPDGKKNTKKRHSFTSLSMASKASQAAQQRHSMEISPPVLISSSNPAAAARIGELAGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPAEAPYPAALATLNPPLPPPPLQAATPTGTAVAAAAGMGPRPTAGPTDQTTHPRPQPRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTSASQGKVPMLTTGPASRGGVLANPPSTGGPAQKPPGNGVAGGPGVPTAVVSAAHVQTSPQAKVLLHASGQMTVNQARSAARTVSAHSQERPTAAVTPIQVQSTPGQSHHPLVSPQPPAPLGPPAHAAASGLGRVGGPLACATAPASIPAASLEPEPSSRPATLLPGTPTSPDSGSAARPDKDGKKEKKGLLKLLSGASTKRKPRGSPPASPTLDAELGAELSCGPPGPPCACPGPCDGDTMAPGPQRRASSLDSAPVAPPPRQPCSSLGPAASEVRPAVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
What is the function of this protein?
Has E3 ubiquitin-protein ligase activity.  In the absence of an external substrate, it can catalyze self-ubiquitination.  Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis.  Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway.  Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation.  Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells.  Plays a crucial role in the migration of neocortical neurons in the developing brain.  Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly.
What are the official names of this protein?
E3 ubiquitin-protein ligase SH3RF1, Plenty of SH3s, Protein POSH, RING-type E3 ubiquitin transferase SH3RF1, SH3 domain-containing RING finger protein 1.
What is the protein family that this protein belongs to?
Belongs to the SH3RF family.
What are the subcellular locations of this protein?
Cytoplasm, perinuclear region. Cell projection, lamellipodium. Golgi apparatus, trans-Golgi network. Note=Colocalizes, with AKT2, in lamellipodia. Colocalizes, with HERP1, in trans-Golgi network.
Protein: GLPK_RHOP2
Sequence: MPFVMAIDQGTTSSRAILFRGDISIAASAQQEFPQHFPASGWVEHEPEDIWASTLATCRAAMEKAGATAADIAAIGITNQRETVVVWDAASGKAIHRAIVWQDRRTAEVCTRMKADGYEPMITDKTGLIIDPYFSGTKVAWLLDNVPGARARAERGELKFGTIDCWLLWRLTGGRVHATDATNASRTLLFNIHTGDWDDELLQLLRVPRSMLPEVKDSSAHFGDSAYELFGAPIAIRGIAGDQQAATIGQACFSPGMIKSTYGTGCFALLITGATPVKSHNKLLTTIAYQLGGKRTYALEGSIFVAGSAVQWLRDGLGIIKHASETGPLADKSDSMQSVYLVPAFVGLGAPYWNPRVRGALFGMTRNTGPAELAHAALESVCYQTYDLWAAMRADWSGADAAPPVLRVDGGMAASDWTMQRLADLLDAPVDRPVIQETTALGAAYLAGLSAGVFPEPQKFADNWRLDHRFRPAMSQATRERKLAGWGRAVKGLLASDEGEG
What is the function of this protein?
Key enzyme in the regulation of glycerol uptake and metabolism.  Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
What are the official names of this protein?
Glycerol kinase, ATP:glycerol 3-phosphotransferase, Glycerokinase, GK.
What is the protein family that this protein belongs to?
Belongs to the FGGY kinase family.
Protein: EIF3F_SCHPO
Sequence: MALGTKHVLHLTKPSSRSSPLNIVIEPAVLFSILDHSTRKSENNQRVIGTLLGTRSEDGREIEIKSCFAVPHNESSEQVEVEMEYHRAMYHLHLKANPREVVVGWYATSPDLDAFSALIQNLYASPAEPGTAPLGTYPHPCVHLTVNTDVSSPLAIKTYVSSPVGITERLADSCAFVPTPFTIRDDEAVRSGLKAVAAPKNDPSRLASLFTDLQQLRRSTLELLSMIERVSDYVQNVIDGSSPANVAVGRYLMKCFSLIPCVEGQDFEKIFSSHLQDVLVVVYLANTLRTQVDIASRLNLLP
What is the function of this protein?
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit F, eIF3f.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit F family.
Protein: SPEE_SALSV
Sequence: MAENTMWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVETITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFTLVIDDGVNFVNQTHQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQDEALDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNDALRHLSSEIIQARFHAAGLKCRYYNPAIHVAAFALPQYLHDALSAQ
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.