PharMolix/UniProtQA huggingface dataset:
Protein: DAD1_CANLF
Sequence: MSASVASVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAGNGSLRNRSNNVFTLVRCFSSLVTLFYSRSPPREVPRGACIALFCERGN
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity.
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, Oligosaccharyl transferase subunit DAD1, Defender against cell death 1, DAD-1.
What is the protein family that this protein belongs to?
Belongs to the DAD/OST2 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: SYL_MYCGA
Sequence: MYNHNLIEKKWAKIWNDQKIYSFQIDKNKPKYYILDMFPYPSGKGLHVGHVKAYMATDVISRWKNALGFNVLHPIGWDAFGLPAEQYAIQTNNHPAKFTQENINNFRTQLKRLGFNYDYRLEVDTTNKNYFKWTQWIFKKLYEHDLAYQADIEVNWCEQLGTVLANEEVLTDENGNKISERGSYPVIKKKMRQWVLKITAFADQLIDDLENLNWPNSIKAMQVNWINKSVGASIKFEIDQLDNQTIEVFSSRADTLFGASFLALSFDHPLVKQKLITDKNNAIEQFIKDNSIDQRVRYQGINTNYFAIHPITKKKIPIYLADYILSDYGTGAVMGVPAHDERDYQFAKQYDLEIIPVIKADQYPYLLDGEHINSEFNNGLNNEQAIQKTIAYLREHNLGDQKINYKLRDWIFSRQRYWGEPFPVLFDEEDNIYLLKDSELPVELPQLSDFSPNKDGLPPLANADDQWLHPIIDQKKYRREINTMPQWAGSCWYYLAYLLKLTDLNQADGDQNYLALNSEKAKELFDHFMPVDLYVGGQEHAVLHLLYARFWYKFLHHIKIVSSTEPFSQLINQGMILGEDNTKMSKSKGNIINPDDLVLSHGADTIRTYVMFMGPLNASLAWNSNALNGTRKFLERVYNLFDRVEINDSINQNLNYDYHNFLKKINKHLENFEFNLVVSEMMIFINACYKQTQVNKEMITNFLIVLSFFAPYLAEELNSKLNNPTLLYKMRLAQWDEAYLVKNTTTISCSINGKFKLVHEFDLDSDEQEVANYFLNQDLIKRNLENKKLVKTIFVKNKVINFIIK
What are the official names of this protein?
Leucine--tRNA ligase, Leucyl-tRNA synthetase, LeuRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERF1_CAEEL
Sequence: MSAPAAGATAGGDDAADRNVEMWKIKRLIKSLELARGNGTSMISLIIPPKDQVARIQRMLAEEYGTASNIKSRVNRLSVLGAITSVQGRLKLYNKVPPNGLVVYCGTIMTDEGKEKKVNIDFEPFKAINTSLYLCDNKFHTEALQGLLADDNKFGFIIMDGNGCLFGTLQGNTREVLHKFTVDLPKKHGRGGQSAVRFARLRNEKRHNYVRKVAENSVEQFIKNDKVTVAGLILAGSADFKTELGQSDMFDQRLQAKMIKTVDIAYGGENGFNQAIELAADTLASVKFIQEKKLIGGYFDEISQDTGKYVFGVKDTLAALEMGAIETLICWENLDIVRYKMKNSLGEDILLNLRPDEEKDKSHFTDSETGQDMEIIETMPLLEWFANNYKNFGAALEIVTDKSQEGAQFVRGFGGIGGLLRYRVDLAHVDLEDELDNIDLDDYSRAAVVSHWAPYSFLLLFKLVSSFFFINLFINYPALSNYNISLSQSSSSLIAISHTTLYSKFLFHFIEFAPRVPHYCRFVWSVDAFSSAGKASHVCQHTEKETFHARNEDAIGGLFNRTKVEARATHSHSMTSTLSLPSVDVSTRNSNDF
What is the function of this protein?
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
What are the official names of this protein?
Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, eRF1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic release factor 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYT_JANMA
Sequence: MITVRLPDGSQREFDTPVTVAQVAANIGTGLAKAALAGKVNGDVVDTSYLIEKDSDLAIITDKDAEGIDVIRHSTAHLLAYAVKELFPDAQVTIGPVIDNGFYYDFSYKRPFTPEDLVAIEKKMTELAKKDEPVTRKVMPRDEAVAYFKSIGEAYKAEIIESIPADQEVSLYTEGKFTDLCRGPHVPSTGKLKVFKLMKLAGAYWRGDSKNEMLQRIYGTAWAKKEEQEAYLHMLEEAEKRDHRKLGKQLDFFHFQEEAPGLIFWHPKGWSIWQQVEQYMRKVYQDNDYQEVKAPQILDRGLWEKTGHWDNYRENMFVTESENRSYALKPMNCPGHVQIYNSDMRSYRDLPLRYGEFGQCHRNEPSGALHGMMRVRGFTQDDGHIFCTEEQIAEEVTAFHAQAMAVYAAFGFENIDVKLALRPDSRIGTEESWDIAEESLRSALRACGVSWTELPGEGAFYGPKIEYHLKDSLGRAWQVGTVQIDPSMPGRLGAEYVAVDNTRKTPIMLHRAIVGSLERFIGILIEHYAGALPLWLAPVQIAVLNISDAQAEYAQAVAQNLKKQGFRVHLDLRNEKITYKIREHSVQKLPYIIVIGDKERDAGTVAVRARGNVDLGVMPVDLLVDRLNSEIDAKA
What is the function of this protein?
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).  Also edits incorrectly charged L-seryl-tRNA(Thr).
What are the official names of this protein?
Threonine--tRNA ligase, Threonyl-tRNA synthetase, ThrRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFA_TRIL1
Sequence: MREQLEQMRQQALSAIAAATTEEMLNEVRVRYLGRKGELTGLMKGLGSLPADERPKVGQLVNTVKDEVEALIEQTMNRAREEATAKRLATERIDISLPGRGRRQGSKHPVTLVIEEVSEIFAGLGFSVAEGPEIEHDWYNFEALNFPPEHPARDMQDTFFVENELLLRTHTSPVQIRTMLKQKPPVRIIAPGTVYRCDSDATHSPMFHQIEGLMVDSQVSFADLKGILTTFTNQLFGQKTGVRLRPSFFPFTEPSAEVDIACVICGGSGCRVCKQTGWLEILGAGMVDPEVFRHVGYDPETISGFAFGMGIERIAMLKYGISDMRLLFENDVRFLKQF
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NORW_ECODH
Sequence: MSNGIVIIGSGFAARQLVKNIRKQDATIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAEQFNLHLFPQTWVTDIDAEARVVKSQNNQWQYDKLVLATGASAFVPPVPGRELMLTLNSQQEYRACETQLRDARRVLIVGGGLIGSELAMDFCRAGKAVTLIDNAASILASLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGIQATLDRQRNIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNTDIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTERQGMVARGVDDADQLRAFVVSEDRMKEAFGLLKTLPM
What is the function of this protein?
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase.  Reduces the rubredoxin moiety of NO reductase (By similarity).
What are the official names of this protein?
Nitric oxide reductase FlRd-NAD(+) reductase, Flavorubredoxin reductase, FlRd-reductase, FlavoRb reductase.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRI_VIBC1
Sequence: MAKETQLQVEAIKNGTVIDHIPAQIGIKVLKLFDMHNSSQRVTIGLNLPSSALGHKDLLKIENVFINEEQASKLALYAPHATVNQIENYEVVKKLALELPEKVNNVFECPNSNCITHNEPVASSFQVFEKKEEIRLKCKYCEKVFAREIVTER
What is the function of this protein?
Involved in allosteric regulation of aspartate carbamoyltransferase.
What are the official names of this protein?
Aspartate carbamoyltransferase regulatory chain.
What is the protein family that this protein belongs to?
Belongs to the PyrI family.
Protein: PURL_RUEPO
Sequence: MQEPAITPDLIAAHGLKPEEYDMILEIIGREPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTSGPQVICGPGENAGVVDIGDGQAVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIASMNALSFGEPSHPKTRQLVNGVVEGIGGYGNCFGVPCVGGEVRFHPAYNGNCLVNAFAAGLADSDKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVGDPFTEKRLMEATLELMQTGAVISIQDMGAAGLTCSAVEMGDKGGLGVRLDLENVPQREENMTAYEMMLSESQERMLMVLKPELEAEARAVFEKWDLDFAIVGETIAEDRFLIMHHGEVKADLVLSKLSSTAPEYDRPWVPTPAAEPLAEVPQIDPIDGLRALLASPNYGGKQWVYEQYDTMVMADSARTPGLGAGIVRVHGTDKALAFTSDVTPRYVRANPEEGGKQAVAEAYRNLTAVGARPLATTDNLNFGNPEKPEIMGQFVGAIKGIGAACAALDMPIVSGNVSLYNETDGTAILPTPTIGAVGLLASTDEIIGKEVREGHVALVVGETTGHLGQSALLAEVFNREDGDAPHVDLEAERRNGDFIRANRALIKACTDLGDGGLALAAFELAEGAGVGLHLDDAPTEILFGEDQARYLVACNFDQAEALMSAAGQTGVTVTSVGRFTGDTVRIGGSEALLADLAATFRASFAAAVA
What is the function of this protein?
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway.  Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.  The FGAM synthase complex is composed of three subunits.  PurQ produces an ammonia molecule by converting glutamine to glutamate.  PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner.  PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
What are the official names of this protein?
Phosphoribosylformylglycinamidine synthase subunit PurL, FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II.
What is the protein family that this protein belongs to?
Belongs to the FGAMS family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1228_PARMW
Sequence: MPETNGTEADSSGPRPGLRLELQAIDLDRDGHGLARWQGWVVVVPGLLPGERAKVQLQQRQKSRWLSRISERLDSSPTRRRPPCILAQDCGGCTLQHLEESAQRNWKQNQLHQTMLRLGGIDHPQAPALTDQRGLGYRNRGLIPLRRGEDDRLRMGYFRRGSHRIVNLSRCPVLDPRLDALVEPLKQDLDTSGLSADHDLSHSQGLRHLGLRIGHHTGEVLITVVSSQQLPALQRLAQQWIERWDPVKGVTLNLQPRRTNQILGATTTVLAGAPTIRELFCGLQLQLSTTTFFQINTPQAERIVACIVSWLSQAELAGPIVDAYCGIGTISLPLAAQGHHVVGLEINPDSIDQARSNADANGLGARTEFQAGDVANLLKETLATCSALVVDPPRRGLESSVIEAILSDPPGLLAYLSCDMATQARDLKRLLQPEGPYRLEQLQPVDFFPQTTHLENLAFLRRVSS
What are the official names of this protein?
Uncharacterized RNA methyltransferase SYNW1228.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
Protein: OTX2_HUMAN
Sequence: MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL
What is the function of this protein?
Transcription factor probably involved in the development of the brain and the sense organs.  Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
What are the official names of this protein?
Homeobox protein OTX2, Orthodenticle homolog 2.
What is the protein family that this protein belongs to?
Belongs to the paired homeobox family. Bicoid subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: GUAA_ECOUT
Sequence: MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPRAPQYVFEAGVPVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVVNDSALVRGIEDALTADGKPLLDVWMSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVLDMFGDHFGLNIVHVPAEDRFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: Y072_AFV2P
Sequence: MIERKYDVDGKEVIVKIEILGAVPPQVVFEIVADKDTLSKYIDGNTLSFAIDIDDIFDAIRETLAPKKVLRD
What are the official names of this protein?
Uncharacterized protein ORF72.
Protein: KRR1_YEAST
Sequence: MVSTHNRDKPWDTDDIDKWKIEEFKEEDNASGQPFAEESSFMTLFPKYRESYLKTIWNDVTRALDKHNIACVLDLVEGSMTVKTTRKTYDPAIILKARDLIKLLARSVPFPQAVKILQDDMACDVIKIGNFVTNKERFVKRRQRLVGPNGNTLKALELLTKCYILVQGNTVSAMGPFKGLKEVRRVVEDCMKNIHPIYHIKELMIKRELAKRPELANEDWSRFLPMFKKRNVARKKPKKIRNVEKKVYTPFPPAQLPRKVDLEIESGEYFLSKREKQMKKLNEQKEKQMEREIERQEERAKDFIAPEEEAYKPNQN
What is the function of this protein?
Required for 40S ribosome biogenesis.  Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.  Essential for vegetative growth.
What are the official names of this protein?
KRR1 small subunit processome component, KRR-R motif-containing protein 1, Ribosomal RNA assembly protein KRR1.
What is the protein family that this protein belongs to?
Belongs to the KRR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: YBD4_ENCCU
Sequence: MKQHTLQLEGVTLDVPNQNLSSNEKYARLINGLTADFKSGNVYAFMGTSGSGKTTTLETIAGLVPSGSRTGGRILVDGQERNPDEFPYEFAYGDQLGYIIDELTVEEFVYYYVVSSLPEESKERVREKMDEVLENLLNIGHIRHNKMKNISGGEQKRANLARTFTKMLLLEGELKVVLLDEPTSELDAGLALKLGEFLRDYARRSNSIVLVTVHQPGAELYNTFDNLLFMNNGEKLYLGPSRDFIKFLGTKGIHNDGGPETNMEFLFSLFTKGSKMSKKYEKQLEQIAKEMNEEKKEEKKLRTSDDTEINFIPNLYVSFQMAIRQIIIDWRNREILYSLAMPIAMALFLVTGKYIYKDFSIATIKASMLSLSLYYVMNPSGLMNDKHYVTEESNRKLYGAAEVWFSSLISDTLVSILKYCIFFGIIYAFGLISMDHAFLGQVLMYTLGGTVSSMLFRSMASPLSTLGKVFNTTMVLMFQLSGALLGAGALLGALTLWISVIPEGSIPQEEIDAFISNFFDSTGSTGSTSIFSKVGSWVIRFICLVPKVVRSFLRILFLMFHPFAFFHSSILDAEKSSYKLFF
What are the official names of this protein?
ABC transporter-like protein ECU11_1340.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ARNF_SODGM
Sequence: MGYGWALFSVALVSAAQLLLKWVMMHLPPLGALRLWLDPAYAEPLALLMGGLLAYVCSMGCWFMALRRLPLNKAYPLLSLSYVLVAACALMIPEFNERFTFSRLMGVALICGGLLLICLPAGGKGDTPRR
What is the function of this protein?
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
What are the official names of this protein?
Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF, L-Ara4N-phosphoundecaprenol flippase subunit ArnF, Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF.
What is the protein family that this protein belongs to?
Belongs to the ArnF family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DNLJ_ACIC5
Sequence: MSHASAAQQIESLRESIRHHEYLYYVQDQPEIDDLAFDELMRKLQRLEAEHPELITPDSPTQRVGGKPKEGFAKVAHSRPMLSLDNVNSEEELRDWERRVREQAGQNAEIEYVCEYKLDGLSMALHYRDGQLARGLTRGDGEIGEDVTTNVRTIRSVPLSIADGKLQQAKMPANFEVRGEVVMPFTAFEKLNEEREAQGLAPAANPRNAAAGTIRTLEPNIVAQRRLDFYAYFALTEKGEDAFGEQEEALDALATLGFRVNQHRHAAKSIETVVEFVNRAEEHRSRLGYEIDGVVVKVNSAVLQRRLGYTGRAPRWAVAYKFAARSGVTQVEDIQVQVGRTGKLTPVAWLAPVQVGGTTVTRATLHNADEIERLGLRIGDFVRIERGGDVIPKVVEVVDDAEHPRGTKHFHFPHACPACGSEVVRTPGEADYRCVNTDCPARLRESLLHFASRGVMNIEGMGEAIVMQLLGRGLVKTVSDIYSLTEEQLVSLERMGKKSATALLGEIDKSRQAPLDRVLFGLGIRFVGERTAQALAEEYGSMDALMQASREELERVNDVGPRVSEAIREFFDEPRNRDLVERLREAGLRFTGEKRKKTSQLAGLTFVLTGTLPGLSRDEAKGKIENAGGHVSGSVSKKTNYVVAGADAGSKLEKANSLGVPVIDEAALIKMLETEQA
What is the function of this protein?
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.  It is essential for DNA replication and repair of damaged DNA.
What are the official names of this protein?
DNA ligase, Polydeoxyribonucleotide synthase [NAD(+)].
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
Protein: IF4A_DEBHA
Sequence: MASEGITEIDSGLIETNYDNVVYTFDDLNLKPNIVRGIFGYGYESPSAIQQRAILPITEGRDVLAQAQSGTGKTATFTISALQRIDENEKSTQALILAPTRELALQIQNVITHIGLYLNVTVHASIGGTSMKDDIEAFKSGVQIVVGTPGRVFDMIERRFFKTDKVKMFILDEADEMLSSGFKEQIYNIFRLLPETTQVVLLSATMPQDVLEVTTKFMNNPVRILVKKDELTLEGIKQFYINVEQEDYKFDCLCDLYDSISVTQAVIFCNTRSKVEFLTTKLKGENFTVSAIHADLPQADRDTIMNEFRSGSSRILISTDLLARGIDVQQVSLVINYDLPANKENYIHRIGRGGRFGRKGVAINFVTDQDVGMMREIEKFYSTQIEEMPADIGALFN
What is the function of this protein?
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome.  In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase eIF4A, Eukaryotic initiation factor 4A, eIF-4A, Translation initiation factor 1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. eIF4A subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLK_PSEA7
Sequence: MNNDKNGSSGGLALIGDIGGTNARFALWRGQRLESIAVLACADYPRPELAVRDYLARVGESLANIDSVCLACAGPVGAGDFRFTNNHWSINRAAFREELGLDHLLLVNDFSTMAWAASRLGADELVQVRPGSAQADRARLIIGPGTGLGVGSLLPLGEGRWEVLPCEGGHVDLPVTSARDFAVWESLRERYGHVSAERVLSGNGLLALYEISCALDGIPVRATSAAEVGALALAGDAQADAVLEHFFLWLARVAGNAALTVGALGGVYITGGIVPRFRERFLASGFAGAFASRGKTSGAYLQDVPVWIMTAEHPGLLGAGVALQQALDAESRTGVRATA
What are the official names of this protein?
Glucokinase, Glucose kinase.
What is the protein family that this protein belongs to?
Belongs to the bacterial glucokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYH_THEFY
Sequence: MSEQRIIRPTPISGFPEWTPRIRSVELRWLDHIRRGFERYGFSSVETPSVEVLDVLLSKGETSQEIYTLQRLQADADDSSDARLGLHFDLTVPFARYVAQHFNDLVFPFKRYQIQRVWRGERPQEGRFREFTQCDIDVINVDRIPLHFDAELPRIVHEVLTGLDIPAWTLNINNRKVLQGFYEGLGITDPLAVIRAVDKLHKIGADAVREILIDQAGLSSDQAAACLELAEIRGSDTTVVDAVAKLGVSHPTLTAGLDELGEVLDELSDLPSGSVVADLSIARGLDYYTGTVYEATFNDDPGYGSICAGGRYENLAGQFIRRSLPGVGISIGLTRIFAKLVSEGRITGGRFCPTDVLVVLPSDERRSAALAVAAQLRERGFNTEVYHQAAKIGKQIQYAVKKDIPFVWFPPFDDGRPHEVKNLATGEQVEADPASWNG
What are the official names of this protein?
Histidine--tRNA ligase, Histidyl-tRNA synthetase, HisRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_STAAW
Sequence: MKILLIGYGAMNQRVARLAEEKGHEIVGVIENTPKATTPYQQYQHIADVKDADVAIDFSNPNLLFPLLDEEFHLPLVVATTGEKEKLLNKLDELSQNIPVFFSANMSYGVHALTKILAAAVPLLDEFDIELTEAHHNKKVDAPSGTLEKLYDVIVSLKENVTPVYDRHELNEKRQPQDIGIHSIRGGTIVGEHEVLFAGTDETIQITHRAQSKDIFANGAIQAAERLVNKPNGFYTFDNL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ETHE1_HUMAN
Sequence: MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCGVQTPTA
What is the function of this protein?
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix.  Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues.  ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH).  Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase.  First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).
What are the official names of this protein?
Persulfide dioxygenase ETHE1, mitochondrial, Ethylmalonic encephalopathy protein 1, Hepatoma subtracted clone one protein, Sulfur dioxygenase ETHE1.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Mitochondrion matrix.
Protein: METN_FRATO
Sequence: MIQIKNLKKEYRTNNTSNLVLDNINLEIKQGEIFGIIGHSGAGKSSLLRCLNLLEQPTDGSIFIADENITKKNSKQLREFRKKVAMIFQHFNLLSSRNVFENIALPLEIQGIPKSEIKKRVFELLDLVELPNKANAYPQELSGGQKQKVAIARALALNPLVLLSDEATSALDPTSTKQILALLKRLNKELGLTIVLITHEMDVVRKICDRVAIIDKGRIAEMGKTLDVFLNPQAPVTRSFVETSIHTKVPDFIAKKLQDNPYSYDNTYPVVQLTFYGDKGKMPIIAEISRQFNATASIIQANIETIQDQIVGIAICHITGERQDWENALRFLSNQDVNLKVLGYATADNI
What is the function of this protein?
Part of the ABC transporter complex MetNIQ involved in methionine import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Methionine import ATP-binding protein MetN.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RNH2A_YEAST
Sequence: MVPPTVEASLESPYTKSYFSPVPSALLEQNDSPIIMGIDEAGRGPVLGPMVYAVAYSTQKYQDETIIPNYEFDDSKKLTDPIRRMLFSKIYQDNEELTQIGYATTCITPLDISRGMSKFPPTRNYNLNEQAHDVTMALIDGVIKQNVKLSHVYVDTVGPPASYQKKLEQRFPGVKFTVAKKADSLYCMVSVASVVAKVTRDILVESLKRDPDEILGSGYPSDPKTVAWLKRNQTSLMGWPANMVRFSWQTCQTLLDDASKNSIPIKWEEQYMDSRKNAAQKTKQLQLQMVAKPVRRKRLRTLDNWYR
What is the function of this protein?
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids.  Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication.  Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
What are the official names of this protein?
Ribonuclease H2 subunit A, RNase H2 subunit A, RNase H(201), RNase H(35), Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family. Eukaryotic subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PUR7_LEIXX
Sequence: MTEMPGWKHVYSGKVRDLFVPETAEGLTETDTVLVVASDRVSAFDHVLEPGIPGKGELLTALSLWWFDRLDAPNHLIPDHTLEGERARERIPAAVSGRSMLVKPLDMFPIECVVRGYLTGSGWQEYQESQSVCGLPLPAGLSDGDRLPEPIYTPAWKAPLGEHDENISYERTIELVGAETAGTLRELSLAVYGRGAAIAEKRGVIIADTKFEFGAERETGEITLADEVLTSDSSRYWDAAATSDVYTPKERMASFDKQIVRDWLAANWDRTGTPPALPAEIVERTAGRYRALVERLTGA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: CAZA1_PONAB
Sequence: MADFDDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFALYNMDQFTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEVDGGLKSWRESCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAKEFIKIIENAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
What is the function of this protein?
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends.  Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.  May play a role in the formation of epithelial cell junctions (By similarity).  Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure.  The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
What are the official names of this protein?
F-actin-capping protein subunit alpha-1, CapZ alpha-1.
What is the protein family that this protein belongs to?
Belongs to the F-actin-capping protein alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y4013_DESHY
Sequence: MRIAIVGGQNHNQETYGKLLGKTGRVEIHFYDGIPKKHNKRNLEKLIKDVDLVIVILGACSHASMWDTKKAAKKCHKEVLFSRGIGISSIVKQIAGKLAYTA
What are the official names of this protein?
UPF0751 protein DSY4013.
What is the protein family that this protein belongs to?
Belongs to the UPF0751 family.
Protein: CRCB_PSYA2
Sequence: MQWLAIGLGAAFGACLRGWLARFNPLHHWIPLGTLGANVLGGLLIGLALVWFERMGSGLSPNIRLFVITGFLGGLTTFSTFSAEVFTFIHHGRLLAALGLVGLHVGMTLLATALGFYCFKLVL
What is the function of this protein?
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
What are the official names of this protein?
Putative fluoride ion transporter CrcB.
What is the protein family that this protein belongs to?
Belongs to the CrcB (TC 9.B.71) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.