PharMolix/UniProtQA huggingface dataset:
Protein: IFNG_CAPHI
Sequence: MKYTSSFLALLLSVLLGFSGSYGQGPFFKEIENLKEYFNASNPDVAKGGPLFSEILKNWKEESDKKIIQSQIVSFYFKLFENLKDNQVIQRSMDIIKQDMFQKFLNGSSEKLEDFKKLIQIPVDDLQIQRKAINELIKVMNDLSPKSNLRKRKRSQNLFRGRRASM
What is the function of this protein?
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.  Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.  Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes.  Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription.  Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits.  In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading.  Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference.  Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity).  Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).
What are the official names of this protein?
Interferon gamma, IFN-gamma.
What is the protein family that this protein belongs to?
Belongs to the type II (or gamma) interferon family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS16_ECO7I
Sequence: MVTIRLARHGAKKRPFYQVVVADSRNARNGRFIERVGFFNPIASEKEEGTRLDLDRIAHWVGQGATISDRVAALIKEVNKAA
What are the official names of this protein?
30S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
Protein: FRS4_ARATH
Sequence: MEFETHEDAYLFYKDYAKSVGFGTAKLSSRRSRASKEFIDAKFSCIRYGSKQQSDDAINPRASPKIGCKASMHVKRRPDGKWYVYSFVKEHNHDLLPEQAHYFRSHRNTELVKSNDSRLRRKKNTPLTDCKHLSAYHDLDFIDGYMRNQHDKGRRLVLDTGDAEILLEFLMRMQEENPKFFFAVDFSEDHLLRNVFWVDAKGIEDYKSFSDVVSFETSYFVSKYKVPLVLFVGVNHHVQPVLLGCGLLADDTVYTYVWLMQSWLVAMGGQKPKVMLTDQNNAIKAAIAAVLPETRHCYCLWHVLDQLPRNLDYWSMWQDTFMKKLFKCIYRSWSEEEFDRRWLKLIDKFHLRDVPWMRSLYEERKFWAPTFMRGITFAGLSMRCRSESVNSLFDRYVHPETSLKEFLEGYGLMLEDRYEEEAKADFDAWHEAPELKSPSPFEKQMLLVYSHEIFRRFQLEVLGAAACHLTKESEEGTTYSVKDFDDEQKYLVDWDEFKSDIYCSCRSFEYKGYLCRHAIVVLQMSGVFTIPINYVLQRWTNAARNRHQISRNLELVQSNIRRFNDLCRRAIILGEEGSLSQESYDIAMFAMKEAFKQCAVTINTIKHPARCEEAAIQAGDPVQEENQYGSTSTQIGPEPNIHAGNVPWQAETRREKRSSLNNTSKKAKHVAQSETVGEGSQEGFQHVADPRQSQAVLAGQFHNTMPGVFQNLINTNFQNIPATNMHQNNPPG
What is the function of this protein?
Putative transcription activator involved in regulating light control of development.
What are the official names of this protein?
Protein FAR1-RELATED SEQUENCE 4.
What is the protein family that this protein belongs to?
Belongs to the FHY3/FAR1 family.
What are the subcellular locations of this protein?
Nucleus. Note=The nuclear localization is independent of the light treatment.
Protein: GLYOX_BACSU
Sequence: MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTSAAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSEEDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKAAKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNAFLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLESVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILLAPATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI
What is the function of this protein?
Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide.  Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine (PubMed:9827558, PubMed:11744710, PubMed:19864430).  Can also oxidize the herbicide glyphosate (N-phosphonomethylglycine) (PubMed:19864430).  Displays lower activities on D-alanine, D-valine, D-proline and D-methionine (PubMed:9827558, PubMed:11744710).  Does not act on L-amino acids and other D-amino acids (PubMed:9827558).  Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (PubMed:12627963).
What are the official names of this protein?
Glycine oxidase, GO.
What is the protein family that this protein belongs to?
Belongs to the DAO family. ThiO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HBA1_TRENE
Sequence: SLSDKDKAAVRALWSKIGKSSDAIGNDALSRMIVVYPQTKIYFSHWPDVTPGSPNIKAHGKKVMGGIALAVSKIDDLKTGLMELSEQHAYKLRVDPSNFKILNHCILVVISTMFPKEFTPEAHVSLDKFLSGVALALAERYR
What is the function of this protein?
Involved in oxygen transport from gills to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit alpha-1, Alpha-1-globin, Hemoglobin alpha-1 chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: MAP21_LEPMJ
Sequence: MGSKSPNGEDRGPNGPSAKKAVASINPPKSAAASGLLRGALEDQDEDGDDDEGKIGADMNVSEKTANGTKKRRRNNKKKKSAQAAQQTAPPRVEIATLFHNRPYPEGEIVEYGINDENLVRTTDEEFRHLAVANNMNDEFLRDYRKAAEVHRQVRQYAQTIAKPGISMTELAREIEDGVRALVGHQGIETGDSLKAGMGFPTGLCINNVAAHWTPNPGAREVVLQHDDVLSIDFGVHVNGRIVDSAFTVAFNPMYDKLLTAVKAATNTGLKESGIDARMDYISETIQEVMESYEVMINGKPLPVKALSSLSGHNILRYKIHGDKQVPFVKTRTSQRMEEGDVFAIETFGSTGIGRTRDDVGVYGYSRNENVSTAGVHLASAKSLLKAIDENFGTLPFSRNYLERIGVKNYHLGMRSLIASGVVECYAPLVDTPGSYVAQFEHTVLLRPNCKEIISRGDDY
What is the function of this protein?
Cotranslationally removes the N-terminal methionine from nascent proteins.  The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
What are the official names of this protein?
Methionine aminopeptidase 2-1, MAP 2-1, MetAP 2-1, Peptidase M.
What is the protein family that this protein belongs to?
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PAPE_TITSE
Sequence: MNRKTLLVIFFVTLLIAEEVNSFRLGGFLKKIWRSKLVKRLRSKGKQLLKEALAPEPAPEPAPEPAPEAAPEAAPEPAAAAPERRRRR
What are the official names of this protein?
Pape peptide.
What are the subcellular locations of this protein?
Secreted.
Protein: CGR1_PHANO
Sequence: MSEAVETQPPAADTVSAVKGMKKNGKQWHDNKTAFRPRANQTSWDKRTAERKALAATKAKEKELKEEKETERQRRIDAIKTKRAAKEERERFQKMEEKMHKRRVERLKRREKRNKMLKS
What is the function of this protein?
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
What are the official names of this protein?
rRNA-processing protein CGR1.
What is the protein family that this protein belongs to?
Belongs to the CGR1 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: DEOR_ECOLI
Sequence: METRREERIGQLLQELKRSDKLHLKDAAALLGVSEMTIRRDLNNHSAPVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKRRAAKLAATLVEPDQTLFFDCGTTTPWIIEAIDNEIPFTAVCYSLNTFLALKEKPHCRAFLCGGEFHASNAIFKPIDFQQTLNNFCPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQKHVLVVDHSKFGKVRPARMGDLKRFDIVVSDCCPEDEYVKYAQTQRIKLMY
What is the function of this protein?
This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes.  It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore-forming protein).  The inducer is deoxyribose-5-phosphate.
What are the official names of this protein?
Deoxyribose operon repressor.
Protein: NTPES_BACSU
Sequence: MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVHLSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGNPLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADFPIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEGQVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGIDAIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSWKVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKDDPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIKNVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDVIDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGGGGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLLAKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLDDAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGNHEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQTFTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVKAIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIVAQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELEDVKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAGIDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYTFTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGEDLGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANTPFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADTAIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDRKKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGGSDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILLAGFLISALGTAMYLHQRRKQNRANQA
What is the function of this protein?
Catalyzes the release of inorganic phosphate from 2',3'-cyclic nucleotides through consecutive 2',3'-phosphodiesterase and 3'- (or 2') nucleotidase activities.  Also possesses a 5'-nucleotidase activity.  Does not catalyze the release of inorganic phosphate from 3',5'-cyclic nucleotides.  Probably plays a role in the cellular reprocessing of nucleotides present in the medium, under conditions of phosphate shortage.
What are the official names of this protein?
Trifunctional nucleotide phosphoesterase protein YfkN.
What is the protein family that this protein belongs to?
Belongs to the 5'-nucleotidase family.
What are the subcellular locations of this protein?
Secreted, cell wall; Peptidoglycan-anchor. Note=Anchored to the cell wall by sortase SrtD.
Protein: GMHA_SHEAM
Sequence: MLERIKDSFTESIQTKIDAAEALPDSIAKAAEMMVACLLGGNKILACGNGGSAGDAQHFSAELLNRYEVERPPLPAIALTTDSSTLTAIANDYSYDEVFSKQILALGQPGDILLAISTSGNSSNVIKAMEAALSRDMTIVALTGKDGGAMAGLLGASDVEIRVPSNVTARIQEVHLLVIHCLCDNIDRTLFPQDENA
What is the function of this protein?
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
What are the official names of this protein?
Phosphoheptose isomerase, Sedoheptulose 7-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the SIS family. GmhA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENC_THEVB
Sequence: MRWQWRIYEEPLQEPLTTAQGVWRSRSGIYLRLEDEQGQVGYGEIAPLPGWGSETLNADIALCQQLPGHLTPEIMATIPEALPAAQFGFATAWQSVGRLPYRVRPWPICALLGSGQAALEQWQQSWQRGQTTFKWKVGVMSPEEEQAILKALLAALPPGAKLRLDANGSWDRATANRWFAWLDRHGNGKIEYVEQPLPPDQWQALLSLAQTVTTAIALDESVVSAAEVQRWVDRGWPGFFVIKTALFGDPDSLSLLLRRGLEPQRLVFSSALEGAIARTAIFHLLETWQPCHALGFGVDRWRSAPLLTTLTAYERLWERLDQ
What is the function of this protein?
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:24872444).  Does not show N-succinylamino acid racemase (NSAR) activity with N-succinyl-L-phenylglycine as substrate (PubMed:24872444).
What are the official names of this protein?
o-succinylbenzoate synthase, OSB synthase, OSBS, 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase, o-succinylbenzoic acid synthase.
What is the protein family that this protein belongs to?
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Protein: ARCH_MYCTO
Sequence: MLHRDDHINPPRPRGLDVPCARLRATNPLRALARCVQAGKPGTSSGHRSVPHTADLRIEAWAPTRDGCIRQAVLGTVESFLDLESAHAVHTRLRRLTADRDDDLLVAVLEEVIYLLDTVGETPVDLRLRDVDGGVDVTFATTDASTLVQVGAVPKAVSLNELRFSQGRHGWRCAVTLDV
What is the function of this protein?
Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB.  Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation.  Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
What are the official names of this protein?
Probable protein archease.
What is the protein family that this protein belongs to?
Belongs to the archease family.
Protein: CEP55_RAT
Sequence: MSSRSPKDLIKSKWGSRPSSSKSDTALEKFKGEIAAFKTSLDEITNGKGKVANKDRSKLLEKIQVLEAEREKNVYYLMEKDKEIQRLKDHLRSRYSSSSLLEQLEEKTKECEKKQQLLESLSRETDILKKQLSATTKRLSELESKASTLHLSQSVPANCFNSSMNSIHEKEMQLKDALEKNQQWLVYDQQREAYVKGLLAKIFELEKRTETAAASLPQQMKKTESEGYLQEEKQKYDHLLENAKKDLEVERQTVTQLRLELDEFRRKYEETQKEVEDLNQLLSSQRKADIQHLEEDKHKTEKIQKLREESSVFKGKLEEERKKSEELLSQVRILYDSLLKHQEEQSRVALLERQMQACTLDFENEKLDRQNMQHQLYVILKELRKAKSQITQLESLKQLHGFTFTEQPFPLQGEPENRVKATSPKSPTAVLNESLVECPKCSVQYPATEHRDLLVHVEYCMK
What is the function of this protein?
Plays a role in mitotic exit and cytokinesis.  Recruits PDCD6IP and TSG101 to midbody during cytokinesis.  Required for successful completion of cytokinesis.  Not required for microtubule nucleation.  Plays a role in the development of the brain and kidney.
What are the official names of this protein?
Centrosomal protein of 55 kDa, Cep55.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis.
Protein: KBRAS_DROME
Sequence: MLNAKIGKVGKVLVCGMKGVGKTALIEQLVYGHVNPETELHPTIEDIYVASVDTGRGGARETLRIYDTAGLQGEQQQLPRHYLQFPDAFVLVYDPMDPRSLDMLADIKADIEKHKEKKEIPVVVLANVRARAAPNPVEKVMDRANIWCQRERIKHYTVNAMERPSLYEPFTTLCARLHPMQTKSTFPQLRQVMQNRQKSEA
What is the function of this protein?
Atypical Ras-like protein that may act as a regulator of NF-kappa-B activity, possibly by preventing the degradation of NF-kappa-B inhibitor cactus.
What are the official names of this protein?
NF-kappa-B inhibitor-interacting Ras-like protein, Kappa B-Ras, KappaB-Ras.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
Protein: RL16_HAES1
Sequence: MLQPKRTKFRKVHKGRNRGIAAGTEVSFGTFGLKAVGRGRLTARQIEAARRAMTRAVKRQGKIWIRVFPDKPITEKPLEVRMGKGKGNVEYWVALIQPGKVMYEMDGVSEEVARHAFALAAAKLPIKTTFVTKTVM
What is the function of this protein?
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
What are the official names of this protein?
50S ribosomal protein L16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL16 family.
Protein: YBEY_JANMA
Sequence: MLQKNKLSLSVQYPDKRLQDIITRPKLRSWVKAALLAPAQITLRFVDAAEGKDLNRNYRGKDYATNVLTFAYTEDEDSETTQADIILCTDVLQLEAAEQEKSVEEHAAHLVVHGVLHAQGYDHESDEEAEEMEALEIEILADLGFRNPYINL
What is the function of this protein?
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
What are the official names of this protein?
Endoribonuclease YbeY.
What is the protein family that this protein belongs to?
Belongs to the endoribonuclease YbeY family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMI_XYLFT
Sequence: MSTPGTLHIVATPIGNLGDLSPRAQHILRTVTMICAEDTRHTRQLLAHFGIERPLLALHAHNEDTLAERIITRLISGESLALVSDAGTPLISDPGFLLVRAARAAGIRVTPVPGPSALIAALSVSGLPSNRFTFEGFLPAKPTARRDRLTHLAHEPRTLIFYEASHRIAECLTDLATIFGSMRIAVVARELTKIFETVLDGTLATLQTQVANDENQRKGEFVIIVQGAADQDAAKITEGRRIYALLKEHLPPSSAAKLAAEITGAPRKALYGG
What is the function of this protein?
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase I, 16S rRNA 2'-O-ribose C1402 methyltransferase, rRNA (cytidine-2'-O-)-methyltransferase RsmI.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSB_XANC8
Sequence: MRNWRWLLLVLAVLLAWLQYRFWFGPGNSGEVMMLEAQVAHQTRDNEGLRQRNQALAAEVKDLKDGEAAIEERARSELGMIKPGETFYRVVEDAPLLPPAAQEAAPPAQPPAASADPVDHP
What is the function of this protein?
Essential cell division protein.  May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
What are the official names of this protein?
Cell division protein FtsB.
What is the protein family that this protein belongs to?
Belongs to the FtsB family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein. Note=Localizes to the division septum.
Protein: AROD_LACLA
Sequence: MRKTKIVVPIMLTELAELEKVSVSDYRTADIVEWRADFLSADEILEMAPKFFEKFKESKILFTLRTVREGGNIQVSEKKYLQILKEILTYNPAYIDVEFFTHGPSFAALKDFRDKMVLSYHNFDEVPSDLTNRLIKMHEEGTAFVKVAVMPERECDVLDLLQITRDMTLEYGDHFISMAMGDLGRLSRISGYLTGSCWTFASLENSSAPGQISLKETEYILDILEK
What is the function of this protein?
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
What are the official names of this protein?
3-dehydroquinate dehydratase, 3-dehydroquinase, Type I DHQase, Type I dehydroquinase, DHQ1.
What is the protein family that this protein belongs to?
Belongs to the type-I 3-dehydroquinase family.
Protein: NOB1_CAEEL
Sequence: MISVMQQMINNDSPEDSKESITSVQQTPFFWPSAAAAIPSIQGESRSERESETGSSPQLAPSSTGMVMPGTAGMYGFGPSRMPTANEFGMMMNPVYTDFYQNPLASTGWYSYGQPYQFTANYSIPSLDGNLSDITIPTTAGSSAATTPNAAMHLPWAISHDGKKKRQPYKKDQISRLEYEYSVNQYLTNKRRSELSAQLMLDEKQVKVWFQNRRMKDKKLRQRHSGPFPHGAPVTPCIERLIN
What is the function of this protein?
Transcription factor, involved in posterior embryonic patterning, morphogenetic movements of the posterior hypodermis, and cell fate specification (PubMed:21408209, PubMed:10781051, PubMed:16824957, PubMed:20824072).  Binds to the 5'-TAGT-3' motif in regulatory elements of genes, including Meis protein psa-3 and microRNA mir-57 (PubMed:16824957, PubMed:20824072).  Involved in a negative regulatory loop with mir-57 to specify posterior cell identities (PubMed:20824072).  Required for asymmetric division of the T hypodermal cell, acting via the regulation of asymmetric expression of psa-3 in cooperation with ceh-20 and the Wnt-MAPK pathway (PubMed:16824957).  Involved in the regulation of the onset of non-apoptotic cell death in the linker cell, acting together with the Wnt signaling pathway (PubMed:27472063).  Involved in promoting embryogenesis, in concert with orphan nuclear receptor nhr-25 (PubMed:15314147).  May regulate expression of transcription factor dmd-3 (PubMed:21408209).
What are the official names of this protein?
Homeobox protein nob-1.
What is the protein family that this protein belongs to?
Belongs to the abd-b homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GCYB2_RAT
Sequence: MEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEEGADGAMLLHYYSDRHGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKAHRQIRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSHSTAVRASVLFGKGPLRDTFQPVYPERLWVEEEVFCDAFPFHIVFDEALRVKQAGVNIQKYVPGILTQKFALDEYFSIIHPQVTFNISSICKFINSQFVLKTRKEMMPKARKSQPMLKLRGQMIWMESLRCMIFMCSPNVRSLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEGRKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALKNKGFEIVRRGEIEVKGKGKMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSPAVPRNTDHQQQVYKGDPADASNEVTLAGSPVAGRNSTDAVNNQPSPDETKTSVVASGPVLSAFCVVL
What are the official names of this protein?
Guanylate cyclase soluble subunit beta-2, GCS-beta-2.
What is the protein family that this protein belongs to?
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_EXIS2
Sequence: MNITVLTLFPEMFTALNHSIVARAQEEKRIELNYVNFRDYSTNRHGRVDDSPYGGGAGMLLMPQPIFDAIADLPEAKRRIIALTPTGRRFDQRLAEEWSKETDLVFLCGHYEGFDQRVHDELVTDEVSLGDFVLTGGELAAMTMIDATVRLLPDVLGKAASHEDDSFSTGLLEYPHYTRPADFRGLTVPEVLLSGNHARIETWRREQALRRTLERRPDLLETADLSETDRRYLQSISGLSND
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RM46_BOVIN
Sequence: MAAPTRRTVLGLARCWRRFESPWSLGSRSLTLAAAPSNSASPWRLLGALCLQRPPLVSKQLTPMQEEMAALLQQMEIERSLYSDHELRALDEAEQLEKKKSDLYEEKDEKNILLVQDLEDMWEQKFLQFKPGARITDADVKNDRSSLHRKLDRNLILLVKDKLGDQDVWMLPQAEWQPGETLRQTAERTLATLSENNLEAKFLGNAPCGHYKFKFPQAVRAEGSLGAKIFFFKALLLTGDFSPAVEKGRHVWASKEELGDYLKPKYLAQVRRFLLDL
What are the official names of this protein?
39S ribosomal protein L46, mitochondrial, L46mt, MRP-L46.
What is the protein family that this protein belongs to?
Belongs to the mitochondrion-specific ribosomal protein mL46 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: SYDND_ROSDO
Sequence: MHMYRSHTCADLSAQDVGKTVRLSGWVHRVRDHGGVLFIDLRDHYGITQVLCDPDSPVFEQMEQVRAEWCIRVDGVVKARDASLINPKISTGEIELFVKDLEVLGASEELPLQVFGDQEYPEETRLKYRYLDLRRANMQANMKLRSDVVASLRQQMWKADFREFQTPIITASSPEGARDFLVPSRLHPGRFYALPQAPQQFKQLLMVSGFDKYFQIAPCFRDEDPRADRSPTDFYQLDIEMSFVTQQDVFDVIQPVLTQVFEQFGNGKAVDQEWPQISYKDAALWYGSDKPDLRNPIKMQSVSEHFAGSGFAIFANLLEQEGTEIRAIPAPGGGSRKFCDRMNAFAQKEGLPGMGYIFWRDQGAGMEAAGPLAKNIGPERTEAIRQQLGLGVGDAAFFLGGKPKAFETVAGKARNHIGMELGLTDQNRFAFAWIVDFPIYEKDSETGRIDFEHNPFSMPQGGLEALQGDPLSVVGYQYDLSCNGYELVSGAIRNHKPEIMFKAFEIAGYGEDEVRKRFGGMVNAFQYGAPPHGGCAAGIDRIVMLLAEEANIREVILFPMNQRAEDLMMSAPSEPESEQLMELGLRVIPKD
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL18_STRP1
Sequence: MISKPDKNKIRQKRHRRVRGKLSGTADRPRLNVFRSNTGIYAQVIDDVAGVTLASASTLDKDVSKGTKTEQAVVVGKLVAERAVAKGISEVVFDRGGYLYHGRVKALADAARENGLKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: ENDON_BPLP2
Sequence: MKYNVDTVRESGWYNKKEWLAVRDYVRQRDKMTCVRCGAFGAKKYEVDHIVELTWENLDDWNIALNPDNLQLLCKSCHNKKTSEYKRGKGVSLW
What is the function of this protein?
Probable HNH endonuclease.
What are the official names of this protein?
Probable HNH endonuclease, Gene product 3, gp3.
What is the protein family that this protein belongs to?
Belongs to the skunalikevirus HNH endonuclease family.