PharMolix/UniProtQA huggingface dataset:
Protein: RECA_STRPI
Sequence: MAKKPKKLEEISKKFGAEREKALNDALKLIEKDFGKGSIMRLGERAEQKVQVMSSGSLALDIALGSGGYPKGRIIEIYGPESSGKTTVALHAVAQAQKEGGIAAFIDAEHALDPAYAAALGVNIDELLLSQPDSGEQGLEIAGKLIDSGAVDLVVVDSVAALVPRAEIDGDIGDSHVGLQARMMSQAMRKLGASINKTKTIAIFINQLREKVGVMFGNPETTPGGRALKFYASVRLDVRGNTQIKGTGDQKETNVGKETKIKVVKNKVAPPFKEAVVEIMYGEGISKTGELLKIASDLDIIKKAGAWYSYKDEKIGQGSENAKKYLAEHPEIFDEIDKQVRSKFGLIDGEEVSEQDTENKKDEPKKEEAVNEEVPLDLGDELEIEIEE
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FTSH_PIRSD
Sequence: MSSDNGSGRQGGDRGGSTGYNLLMYLGFGAIIATLVALYVLQMFQTSLDYTDLERLVAASQYEKDESKLTAGSPGYIDVKVEARNTLRRMRVSNLRKVELGPTAVRGQIDLVELKPVGTSGDRWEPDSKTLRQNVEFRTNLSDKGSNRDDIETAIRNSNIPFRHADPPGPWEQHSQLIIGMLLAAMLIYIVVRRLSAAGSPMSFGRSRGKLYAQEELGITFNDVAGIDEAVEEVREVVDFLRSPEKYQKLGGRIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSLSGSDFVEMFVGVGAARVRDMFQQAEAKAPCIIFIDELDALGKSRGAGIMGGHDEREQTLNALLVEMDGFGSNSGVIVMAATNRPETLDPALLRPGRFDRHVLVDRPDIKGREDILKVHVKNVKLDPTVDLHKVAAITPGFVGADLANLVNEAALLAARAEKTAVGMNEFNEGVERVTAGLEKKQRVMNEDEKLRVAYHESGHALVAYSLPNTDPVHKVSIIPRGLAALGYTMQRPEGDRFLMTQSELESRIQVLLAGTIAEEIIFTDISTGAQNDLERATDIARRMCMEFGMSRLGRVNYRESNRSAFLASGGSGEERVRSVSEQTLREIDQEVRRIIDESIEKVRHILDVRRGALVSLTNRLMEVESVDSDELKRIIDETSPGPLVVPGTLPANTMRSTTEPVITAPATERSG
What is the function of this protein?
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins.  Plays a role in the quality control of integral membrane proteins.
What are the official names of this protein?
ATP-dependent zinc metalloprotease FtsH.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the peptidase M41 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side.
Protein: MA6D1_BOVIN
Sequence: MAWPCISRLCCLARRWNQLDRSDVAVPLTLHSYSDLESEEPIPGGVPSRRGPSPAGSRDPGRDVPLTQYQRDFGVWTAPSGSRDATQGRGPGASSRRTKPSATPGRGVYVLPIGDADAAAVATTSYRQEFQAWTGVKPSRSTKVKPAKVITTHSSGWDGSPRAGFQAPEVRKKFAPNPSAIFQASAPRILNV
What is the function of this protein?
May have microtubule-stabilizing activity.
What are the official names of this protein?
MAP6 domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the STOP family.
What are the subcellular locations of this protein?
Golgi apparatus. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.
Protein: NU2M_CAEEL
Sequence: MIVFISLFTLFLTLLSILTNNVIVWWSIFLLMTVVFILLNKSSKSYTSIFNYFVIQESLGLLFLLCSGGLLQFFIILLKIGVAPLHFWIFNVTNNIFNYGLMWFLTFQKLPFLTILLQIFWLSSVYILLFGLLICYVQIFVMKSYKNLLIISSTESFNWIVLGVFFSMFNTFYLFIYYFVLMVLLISKFSKTSGYNFINWETTLVFLNIPFSVSFFVKIFSLSEIFKYDSFFTLFLLFTMFLSVLAFSFWLINLSMKNNEETSNNNKMNYFIIFPLMVISII
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ALG10_ASHGO
Sequence: MGGEATASEKELQEREDQLSQQIQDEIVMGCVVNLALWPVLLGAAAYVAYKYNCSWVPYPFIDEKFHVGQTVRYLAGRWREWDSKITTPPGLYVIGWAVQRTVGLLVGWNTLSLLRLSNVIGGLVVWPWFVLRPLYFFNALAFWPATLSVFPLLTSYYFLYYTDVWSTILIVGSLTLAVTVPFGERASIWASAICGLLSCLFRQTNIVWNAFVLVVVLERRTMIHKGFNSLRINNYLKLIIHGIENWNSLVLPYAVNFALFLIFLLYNGSVTLGDKSSHVAGFHLVQMFYCLLFITFFSVPVWFCRSFLLNYVSRTVVYPIWTIFEILGIMMIIRFFTVVHPYLLADNRHIAFYLFKKLIGRNRFLKYFVMAPIYHFSTFVYLEAVRPTVFFFHPILPIEVKSPVDLPLQFTHISWSALIICTLLTVVPSPLFEPRYYILPYIFWRIFLLVSPEPFFAVPTEMTYRFGNTRRLAVEFLWFILINAITIVIFATNAFAWETEASLQRIIW
What is the function of this protein?
Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
What are the official names of this protein?
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Alpha-1,2-glucosyltransferase ALG10-A, Alpha-2-glucosyltransferase ALG10, Asparagine-linked glycosylation protein 10, Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10.
What is the protein family that this protein belongs to?
Belongs to the ALG10 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: VAMP7_RAT
Sequence: MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFGFLNEVKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENQSLDRVTETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLARAMCVKNVKLTAIIVVVSIVFIYIIVSPLCGGFTWPSCVKK
What is the function of this protein?
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome.  Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion.  Required for calcium regulated lysosomal exocytosis.  Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi.  Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells.  Required for focal exocytosis of late endocytic vesicles during phagosome formation.
What are the official names of this protein?
Vesicle-associated membrane protein 7, VAMP-7, Synaptobrevin-like protein 1.
What is the protein family that this protein belongs to?
Belongs to the synaptobrevin family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein. Synapse, synaptosome. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney.
Protein: UXUA_ALKCK
Sequence: MRMTFRWYGENNDSVTLEQIKQIPGVEGLVWALHDKVAGEVWPLEDIMQVKEQADRYGFHLDVVESINVHEDIKLGLPTRDAYIENYKESIRNVAKVGAKVICYNFMPVFDWTRTDLFKEMEDGSTALFYEKAKVDNMDPRELVRQTTSNAAFTMPGWEPERLAHIEKSLKAYENVTEDDLWEHLQYFLEQVLPVAEEHGIQMAIHPDDPPWSVFGLPRIITSEAAVERFLQLSNSPAHGITLCSGSLGANPENDIPKIIRRFHDRIPFAHIRNVKIYENGDFIETSHRSQDGSVNIADVVKAYHENGFTGYVRPDHGRHIWNEKCRPGYGLYDRALGIMHLWGLWDAYELEAKRRQS
What is the function of this protein?
Catalyzes the dehydration of D-mannonate.
What are the official names of this protein?
Mannonate dehydratase, D-mannonate hydro-lyase.
What is the protein family that this protein belongs to?
Belongs to the mannonate dehydratase family.
Protein: ELP1_MOUSE
Sequence: MRNLKLHRTLEFRDIQAPGKPQCFCLRAEQGTVLIGSERGLTEVDPVRREVKTEISLVAEGFLPEDGSGCIVGIQDLLDQESVCVATASGDVIVCNLSTQQLECVGSVASGISVMSWSPDQELLLLATAQQTLIMMTKDFEVIAEEQIHQDDFGEGKFVTVGWGSKQTQFHGSEGRPTAFPVQLPENALPWDDRRPHITWRGDGQYFAVSVVCRQTEARKIRVWNREFALQSTSESVPGLGPALAWKPSGSLIASTQDKPNQQDVVFFEKNGLLHGHFTLPFLKDEVKVNDLLWNADSSVLAIWLEDLPKEDSSTLKSYVQLWTVGNYHWYLKQSLPFSTTGKNQIVSLLWDPVTPCRLHVLCTGWRYLCCDWHWTTDRSSGNSANDLANVAVIDGNRVLVTVFRQTVVPPPMCTYRLLIPHPVNQVIFSAHLGNDLAVLDASNQISVYKCGDKPNMDSTVKLGAVGGNGFKVPLTTPHLEKRYSIQFGNNEEEEEEEVNALQLSFLTWVEDDTFLAISYSHSSSQSIIHHLTVTHSEVDEEQGQLDVSSSVTVDGVVIGLCCCSKTKSLAVQLADGQVLKYLWESPSLAVEPWKNSEGIPVRFVHPCTQMEVATIGGEECVLGLTDRCRFFINDTEVASNITSFAVCDDFLLVTTHSHTCQVFSLSGASLKMLQAALSGSHEASGEILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKLMFKEAFECMRKLRINLNLIHDHNPKVFLENVETFVKQIDSVNHINLFFTELREEDVTKTMYPPPITKSVQVSTHPDGKKLDLICDAMRAAMEAINPRKFCLSILTSHVKKTTPELEIVLQKVQELQGNLPFDPESVSVEEALKYLLLLVDVNELFNHSLGTYDFNLVLMVAEKSQKDPKEYLPFLNTLKKMETNYQRFTIDKYLKRYEKALGHLSKCGPEYFTECLNLIKDKNLYKEALKLYRPDSPQYQAVSMAYGEHLMQEHLYEPAGLVFARCGAQEKALEAFLACGSWQQALCVAAQLQMSKDKVAGLARTLAGKLVEQRKHSEAATVLEQYAQDYEEAVLLLLEGSAWEEALRLVYKYDRVDIIETSVKPSILEAQKNYMDFLDSETATFIRHKNRLQVVRALRRQAPQVHVDHEVAHGPESDLFSETSSIMSGSEMSGRYSHSNSRISARSSKNRRKAERKKHSLKEGSPLEGLALLEALSEVVQSVEKLKDEVRAILKVLFLFEFEEQAKELQRAFESTLQLMERAVPEIWTPAGQQSSTTPVLGPSSTANSITASYQQQKTCVPALDAGVYMPPKMDPRSQWKLSLLE
What is the function of this protein?
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity).  The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:23717213).  Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:22854966).  ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity).  May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity).
What are the official names of this protein?
Elongator complex protein 1, ELP1, IkappaB kinase complex-associated protein, IKK complex-associated protein.
What is the protein family that this protein belongs to?
Belongs to the ELP1/IKA1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FKBP3_YARLI
Sequence: MSNNANNCLPLASYTLAVFPGIPVAPIEQDFPVSVRITMAAIDPARIEGDEEEPATLRILKPADNFDDEDDEDDEDEDDDDEDDEVSAEDMAQIKKLIAANEDGLDEVEGGDDDEDDDEDDEMEFEEDDEDDDDEGEIEDFVVCTLSPKFGYQQTLDLVITPGEQIMFEVTGSYAIHLSGNYIEHPYDMEDEDELLALGEDDEDDEDELDEGEYDLSPDEDEVINGDERLVELMEQDDEDDEDDEDEEEEPVVEPKKILKRAAEEKKQEKAAKKAKVAFTKNLEQGPTPSEPKPKLVTRQLEGGVKIEDRTVGEGPSAKVGSKVGVRYVGKLANGKVFDSNSKGKPFYFSVGKGEVIRGWDIGVQGMKVKGERRIIIPPGMAYGKQKLPGIPPNSQLTFDVKVVNIK
What is the function of this protein?
PPIases accelerate the folding of proteins.  It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
What are the official names of this protein?
FK506-binding protein 3, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase.
What is the protein family that this protein belongs to?
Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: HIS4_RHORT
Sequence: MILFPAIDLKDGQCVRLRKGEMDQATVFNDSPADQAAAFALAGCRWIHVVDLNGAFAGRPVNAPAVEAILAAVDLPVQLGGGIRDLAAIDLWLDKGVRRVILGTVALRDPQLVREACKRHPGRIAVGIDARGGMVAVEGWAETSAVSALDLALRFEDAGVAAIVHTDIDRDGLLAGPNLDATAALAERLTTPVIVSGGVASLDDLRAIRARAAAGLEGVISGRALYDGRIDLAEALAVLAD
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MPRA_MYCLE
Sequence: MRILAVDDDRAVRESLRRSLSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRTKPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGESRLIHTVRGVGYVLRETPP
What is the function of this protein?
Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host.  Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).
What are the official names of this protein?
Response regulator MprA, Mycobacterial persistence regulator A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RF3_LATSS
Sequence: MTPTELKTAVERRRTFAIISHPDAGKTTITEQLLLFGGVIRQAGTVKGKKSGQFAKSDWMDIEKQRGISVTSSVMQFDYAGKRINILDTPGHEDFSEDTYRTLMAVDAAVMVIDSAKGIEPQTKKLFKVCKMRGIPIFTFMNKLDRDGREPLDLIAELEELLDIEGCAMNWPIGMGKDLRGLYDIANKRIEMYRPEDEANPYLALDEEGKIAGDNPLKEDSVYTQALDDIELIGEAGNAYDPAKIATGDQTPIFFGSALTNFGVKTFLEAFVDMAPAPEAHQTQEETQVEPTNEDFSGFIFKIQANMNPAHRDRIAFVRVCSGEFQRGIDVTLTRTGKKMRLNNSTEFMADAREQVTSAVAGDIVGLYDTGNFQIGDTIHTGKEAISFEKLPQFTPELFMRVTAKNVMKQKSFHKGIQQLVQEGAIQLYKTYTTSDYILGAVGQLQFEVFQYRMQHEYNSEVIMEPIGSRTARWIDPEKLDQSMSSSRNLLVKDIHDQPLFLFENKFAERWFQDKYPEVKLTAKL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TUSA_SHIDS
Sequence: MTDLFSSPDHTLDALGLRCPEPVMMVRKTVRNMQPGETLLIIADDPATTRDIPGFCTFMEHELVAKETDGLPYRYLIRKGG
What is the function of this protein?
Sulfur carrier protein involved in sulfur trafficking in the cell.  Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA.  Interacts with IscS and stimulates its cysteine desulfurase activity.  Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation.  Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.
What are the official names of this protein?
Sulfur carrier protein TusA, Sulfur mediator TusA, Sulfur transfer protein TusA, tRNA 2-thiouridine synthesizing protein A.
What is the protein family that this protein belongs to?
Belongs to the sulfur carrier protein TusA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MINE_SHISS
Sequence: MALLDFFLSRKKNTANIAKERLQIIVAERRRSDAEPHYLPQLRKDILEVICKYVQIDPEMVTVQLEQKDGDISILELNVTLPEAEELK
What is the function of this protein?
Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites.  This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.
What are the official names of this protein?
Cell division topological specificity factor.
What is the protein family that this protein belongs to?
Belongs to the MinE family.
Protein: PRMA_RHOPS
Sequence: MTETASTRASFVIGDEAAARRVTDLLGESFDDGELAIAAFERPDRSWEVSLHFGEMPNLDGVRALVAQAAGDAAAAAMTVESIAAKDWVAASLEGLVPVPAGRFVVHGSHDRARIPSNKLGIEIEAALAFGTGHHGTTRGCLTLLDLVLRAGPPRSVLDLGTGTGVLAIAAAKALRQPVLATDIDRQSVAVAKENARLNGVGNLVEAVHATGFSAPVFAAWGPFDLVLANILANPLRQLSTPMSQHLAPSALVILSGLLQPQAQSVIAAYRARGCVLLRQIVIEGWSSLLLAKTF
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUP98_CAEEL
Sequence: MFGQNKSFGSSSFGGGSSGSGLFGQNNQNNQNKGLFGQPANNSGTTGLFGAAQNKPAGSIFGAASNTSSIFGSPQQPQNNQSSLFGGGQNNANRSIFGSTSSAAPASSSLFGNNANNTGTSSIFGSNNNAPSGGGLFGASTVSGTTVKFEPPISSDTMMRNGTTQTISTKHMCISAMSKYDGKSIEELRVEDYIANRKAPGTGTTSTGGGLFGASNTTNQAGSSGLFGSSNAQQKTSLFGGASTSSPFGGNTSTANTGSSLFGNNNANTSAASGSLFGAKPAGSSLFGSTATTGASTFGQTTGSSLFGNQQPQTNTGGSLFGNTQNQNQSGSLFGNTGTTGTGLFGQAQQQPQQQSSGFSFGGAPAATNAFGQPAAANTGGSLFGNTSTANTGSSLFGAKPATSTGFTFGATQPTTTNAFGSTNTGGGLFGNNAAKPGGLFGNTTNTGTGGGLFGSQPQASSGGLFGSNTQATQPLNTGFGNLAQPQIVMQQQVAPVPVIGVTADVLQMQANMKSLKSQLTNAPYGDSPLLKYNANPEIDGKSSPASTQRQLRFLAAKKGALSSSSDAQDSSFIIPPISKVMSDLSPAVTRSADVTKDLNYTSKEAPPSLARGLRNSTFNPNMSLTNRSVHESSALDKTIDSALDASMNGTSNRLGVRGSVRRSNLKQLDMSLLADSSRVGRESRVADPDALPRISESERRQDVVTSTPAVDPVQAVIQRHNDRNRDPPSLNLDTTCDEHTGLEPVSAATSSAASVVSTPSEETVNVNSAAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHFSKYGLADDDEPMDGSPPQQALQASSPLQVIDMNTSARDVNNQVQRKKVHKATDAHHQEIILERVPAPAALGDVVPIIRRVNRKGLGGGTLDDSREESCIGNMTTEFNESGHDSIIEEGQQPEKKPKLELLADLEYESSRFIRNLQELKVMPKANDPAHRFHGGGHSAKMIGYGKSKLIDIGIVKGRSSHVGWSETGCLVWSAQPRHNQVLFGTIDRTSDVNENTLISMLDVNVHVSETSRKGPSSQSNSVKSSLTSNFVTYSDSYSSMFAKYIDVAQAGGYDGHVSVWKLISALFPYERREGWSFERGEEIGEWLRTEAVKSVPDDRSADTSSNGVWNQLCLGDIDKAFQIAIDNNQPQLATMLQTSAVCPEATVHCFKAQLDNWKKCETLHLIPKETLKCYVLMSGLSHYEWDQDGKNHSINCLDGLNWIQALGLHVWYLRAWTGLEESYDAYQKDVNAGRAASNRGDLPGELIKLACESQHSVEVVLDCAAGENPNDYFLQWHVWSLLYSVGYRTMSKTSETRLHRNYSSQLEASSLSKYALFVLQHIDDDEERSTAVRSLLDRIARFTDNDMFDSISEQFDIPSEWIADAQFSIAKSVDDSTQLFELAVAAKNYLEICRLFVDDIAPTAVVAGDHDALKAACAMVRPFENQIPEWGATGMVYTDYCRLINLIENDAEEELLQDVLESLETRLHAPTISKNSLQKLSLQTIGRVLFEYRADKNTLPEWTKLLGHRQMFKIFRDRSSWGIERFTIEFD
What is the function of this protein?
Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC) (PubMed:20335358, PubMed:28122936).  Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution (PubMed:28122936).  Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase (PubMed:22238360).  Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes (PubMed:20335358).  Binds nos-2 mRNA, probably indirectly, and promotes its accumulation in P granules (PubMed:20335358).
What are the official names of this protein?
Nuclear pore complex protein Nup98-Nup96.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin GLFG family.
What are the subcellular locations of this protein?
[Nuclear pore complex protein Nup98]: Cytoplasmic granule. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=P granule localization dependent on nucleoporins npp-7, npp-8 and npp-9 which are involved in P granule integrity. SUBCELLULAR LOCATION: [Nuclear pore complex protein Nup96]: Nucleus, nuclear pore complex. Nucleus envelope. Chromosome. Note=Requires mel-28 for chromatin association during early steps of nuclear pore complex assembly.
Protein: DAPB_PSEPK
Sequence: MRRIAVMGAAGRMGKTLIEAVQQTPGAGLTAAIDRPDSSLVGADAGELAALGRIGVLLSDDLAKVADEFDVLIDFTHPSVTLKNLAFCRKHGKAMIIGTTGFTVEEKQLLAEAGKDIPIVFAANFSVGVNLSLKLLDMAARVLGDDVDIEIIEAHHRHKVDAPSGTALRMGEVVANALGRDLQEVAVYGREGQTGARDRKTIGFATVRAGDVVGDHTVLFAAEGERLEITHKASSRMTFAKGAVRAALWLDGREPGLYDMQDVLELR
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSM1_YEAST
Sequence: MTKKLPSELKQTRKSIQTACEFCHTKHIQCDVGRPCQNCLKRNIGKFCRDKKRKSRKRIEKHGTQPYLNLGKRLVIHDVPSKTVSPSSVHLQRDFLSSDQEKPGKTPAHNTNIQYTYNINDNFQSAGSIPRITNFNTNNRQTVLENTSNNISASQAVHLMNDPIIPTVRKSTLNLKSHFLEQHKAMQQPLATNCLVATSNVPVHSGMDDSNKSDDDVDDETNIHFDSMWCNDEYMKLKDIVDISTPFLPNNSQIFSLQESEYPNPSASTRGNSSLHLTNLLNSTKSVNDQKDSSIGHSTSTFNTYDEVVSRPFISLDMLHLNRGANANTHPSHNAKLESECDSSSHSDADLEKHDTDFISPSKFRELVKTPQDLYDNKCLIKPHNYKLAYTKLLTTLRKKFLEGAEIDKSASVKDEHSTQKHNLRYDLEVIIRSILERYAPIFISLTSNMIEEDLLLQEVTLQRALLDLENMAKLVSCTPMCIWRRSGEICFVSNEFYSLTGFNKNLLLDRTSFIFEYLDHKSVSNYFQIFNELLAFGYNDINKRKKLLMLNACSSTSSKITEGFSFTTDGKAIFTKCNLLLSNGLYLKCACCWTVKRDSFNIPILVMGQFLPIFEMD
What is the function of this protein?
Transcription factor which regulates nonfermentable carbon utilization (By similarity).  Binds specifically to 5'-CGGN(8)CGG-3' and 5'-CGGN(9)CGG-3' sequences in the promoter region.
What are the official names of this protein?
Glucose starvation modulator protein 1.
What is the protein family that this protein belongs to?
Belongs to the ERT1/acuK family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BBS4_MOUSE
Sequence: MAEVKLGMKTQVPASVESQKPRSKKAPDFPIVEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQCADNLKQVARSLFLLGKHKAATEVYNEAAKLNQKDWEICHNLGVCYTYLKQFNKAQDQLHSALQLNKHDLTYIMLGKIHLLQGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGVYQKAFEHLGNALTYDPANYKAILAAGSMMQTHGDFDVALTKYRVVACAIPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENARRAYVEAVRLDKCNPLVNLNYAVLLYNQGEKKSALAQYQEMEKKVNFLKDNSPLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKTKHRTNSGSKSATLQQPLGSIQALGQAMSSAAAYRKILSGAVGAQLPKPPSLPLEPEPEPTVEASPTEASEQKKEK
What is the function of this protein?
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia.  The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.  This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome.  Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane.  Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.  The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation.  Required for proper BBSome complex assembly and its ciliary localization.  Required for microtubule anchoring at the centrosome but not for microtubule nucleation.  May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome (By similarity).
What are the official names of this protein?
Bardet-Biedl syndrome 4 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the BBS4 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium, flagellum. Cell projection, cilium. Note=Localizes to the pericentriolar material. Centrosomal localization requires dynein (By similarity). Localizes to the connecting cilium of photoreceptor cells (PubMed:23943788).
Protein: RRF_MYXXD
Sequence: MSGDVVAELKGRIDKSLEGLRTDLTRVRTGRASIAILEGVRVDYYGTPTPLSGVASVNAPEPRLITIKPWEKSVLKDIEKALREANLGINPMNDGEMIRLPFPPLTEERRKDIAKQVKTKGEEFKVTIRNLRRDANEVLKTQLKDKKITEDDHKRITEVVQKQTDAGITQVDEIVKKKEKEVMEV
What is the function of this protein?
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.  May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
What are the official names of this protein?
Ribosome-recycling factor, RRF, Ribosome-releasing factor.
What is the protein family that this protein belongs to?
Belongs to the RRF family.
What are the subcellular locations of this protein?
Cytoplasm.