PharMolix/UniProtQA huggingface dataset:
Protein: OLCI_PENCN
Sequence: MDLVSFAFSGPATHADQAPLYIDAKRPSRSLSEAPFRRLVRSLVAGFKAYGVERGDTVLVQLDNLVIHSALLFGIVGAGGVYMGCSPSSPRHELDHFVSLVEPRLILTVASALSVVRDVCTNKGISWSQICLVDDQSVDHLVSFAQNQSYNPQATPPVRDEGVHFDLKDMVSFGESDWMRIYDEATARITPAAMFSTSGTSGLPKAAIRTHHTIISHHQTVHYDVPYPVTRLMALPMSHSFGDFWSNLFPIRYGHPLYVMPRFDLSTFLNVVHRYNITETYLVPAMVHILNQSTLPVRESLGSLFYIGVSGAPIDADSLQRCQKLLNPQACIGQLWGMTEVGVIFQNRYGDQRYPGSIGKLLENYDIRLVRLDDGTTIHGESTPGELYVRGPGIMLAYQGRDDGIDAQGWFRTGDIAYSEDEHYHIVGRTKELIKVRGYSVAPAEIEAVLLKDPRVHDTMVIGITLPDGSTEVPRAYVVCALGQARPTADEVSALALKNLASYKALDGGVIFVESLPRTGIGKPHRSKLSHLDAQRTKLAALLSPV
What is the function of this protein?
Nicotinic acid-CoA ligase; part of the gene cluster that mediates the biosynthesis of 15-deoxyoxalicine B (PubMed:30090271).  The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase olcI (PubMed:30090271).  Nicotinyl-CoA is then a substrate of polyketide synthase olcA to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase olcH to yield geranylgeranyl-HPPO (PubMed:30090271).  Geranylgeranyl pyrophosphate is provided by the cluster-specific geranylgeranyl pyrophosphate synthase olcC (PubMed:30090271).  The FAD-dependent monooxygenase olcE catalyzes the epoxidation of geranylgeranyl-HPPO and the terpene cyclase olcD catalyzes the cyclization of the terpenoid component, resulting in the formation of the tricyclic terpene moiety seen in predecaturin E (PubMed:30090271).  The cytochrome P450 monooxygenase then catalyzes the allylic oxidation of predecaturin E, which is followed by spirocylization with concomitant loss of one molecule of water to form decaturin E (PubMed:30090271).  Decaturin E is the substrate of the cytochrome P450 monooxygenase olcJ which hydroxylates it at the C-29 position to form decaturin F (PubMed:30090271).  The short-chain dehydrogenase/reductase olcF may catalyze the oxidation of decaturin F to generate the 29-hydroxyl-27-one intermediate, and subsequent hemiacetal formation probably leads to the formation of decaturin C (Probable).  The dioxygenase olcK may be a peroxisomal enzyme that catalyzes the hydroxylation of decaturin C into decaturin A once decaturin C is shuttled into the peroxisome by the MFS transporter olcL (Probable).  Finally the cytochrome P450 monooxygenase olcB catalyzes the oxidative rearrangement to yield 15-deoxyoxalicine B (PubMed:30090271).  In the absence of olcJ, decaturin E may be shunted to a pathway in which it is oxidized to a ketone, possibly by olcF, to form decaturin D, which undergoes further allylic oxidation to yield decaturin G (PubMed:30090271).  Moreover, in the absence of oclK or oclL, oclB can convert decaturin C into 15-deoxyoxalicine A (PubMed:30090271).
What are the official names of this protein?
Nicotinic acid-CoA ligase olcI, 15-deoxyoxalicine B biosynthesis cluster protein I.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: LIP_THELA
Sequence: MRSSLVLFFVSAWTALASPIRREVSQDLFNQFNLFAQYSAAAYCGKNNDAPAGTNITCTGNACPEVEKADATFLYSFEDSGVGDVTGFLALDNTNKLIVLSFRGSRSIENWIGNLNFDLKEINDICSGCRGHDGFTSSWRSVADTLRQKVEDAVREHPDYRVVFTGHSLGGALATVAGADLRGNGYDIDVFSYGAPRVGNRAFAEFLTVQTGGTLYRITHTNDIVPRLPPREFGYSHSSPEYWIKSGTLVPVTRNDIVKIEGIDATGGNNQPNIPDIPAHLWYFGLIGTCL
What are the official names of this protein?
Lipase, Triacylglycerol lipase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. Lipase family.
Protein: REGQ_LAMBD
Sequence: MRLESVAKFHSPKSPMMSDSPRATASDSLSGTDVMAAMGMAQSQAGFGMAAFCGKHELSQNDKQKAINYLMQFAHKVSGKYRGVAKLEGNTKAKVLQVLATFAYADYCRSAATPGARCRDCHGTGRAVDIAKTELWGRVVEKECGRCKGVGYSRMPASAAYRAVTMLIPNLTQPTWSRTVKPLYDALVVQCHKEESIADNILNAVTR
What is the function of this protein?
Mediates the switch from middle to viral late gene expression by associating with host RNA polymerase (RNAP) so that the latter can read without pausing and through transcription terminators preceding late genes (PubMed:18832144, PubMed:10384296, PubMed:31455742).  Competes with host factor sigma 70 for binding to RPOB, the beta-subunit of host RNAP (PubMed:18832144).  To join the elongation complex, binds a specific DNA Q-binding element (QBE) and interacts with RNAP that is paused during early elongation (PubMed:10384296).  Participates in the lysis-lysogeny decision by activating the expression of the late lytic genes (PubMed:25092034).
What are the official names of this protein?
Antitermination protein Q.
What is the protein family that this protein belongs to?
Belongs to the phage antitermination Q type 2 family.
Protein: YNFB_SALG2
Sequence: MNNTLSKRLCLTAMLTLAAVVYTTSAFAETSKLVIESGDSAQSRQEAAMEKEQWNDTRSLRQKVNTRAEKEWDKADAAFDNRDKCEQSANINAYWEPNTLRCLDRRTGRVITP
What are the official names of this protein?
UPF0482 protein YnfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0482 family.
Protein: YCIZ_ECOL6
Sequence: MSEFDAQRVAERIDIVLDILVAGDYHSAIHNLEILKAELLRQVAESTPDIPKAPWEI
What are the official names of this protein?
UPF0509 protein YciZ.
What is the protein family that this protein belongs to?
Belongs to the UPF0509 family.
Protein: RMLA_ACTS5
Sequence: MRGILLAGGTGSRLRPVTWAVSKQLMPVYDKPMIYYPLATLVSCGIREILVITTETEAAQFQRLLGDGSQWGLRLEFAVQQRPGGIAEAFLIGEEFLAGGPVALMLGDNLLHGVDFRPCVQRARETAGGHVFGVAVADPSAYGVVEFDAAGRVLSIEEKPVRPRSPYAVPGFYLYDADVVETARSLRPSARGELEITEVNQAYLRRGALSVTLLGRGAVWLDTGTLADCMRAVDYVRAIDEGQGIKIGCVEEAAWRAGFLDTAQLRALAEPLMSSGYGQYLLALTGDGLSRTPQWPALTAAAG
What is the function of this protein?
Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose.
What are the official names of this protein?
Glucose-1-phosphate thymidylyltransferase, dTDP-glucose pyrophosphorylase, dTDP-glucose synthase.
What is the protein family that this protein belongs to?
Belongs to the glucose-1-phosphate thymidylyltransferase family.
Protein: TRN1_COCOF
Sequence: MANLRESSRDKSRWSLEGMTALVTGGSKGIGEAVVEELAMLGARVHTCARDETQLQESLREWQAKGFQVTTSVCDVSSRDQREKLMETVSSLFQGKLNILVNNAGTCITKPTIDYTSEDFSFLMSTNLESSFHLSQLAHPLLKSSGLGSIVLISSVASVVHVNVGSIYGATKGAMNQLARNLACEWASDSIKVNSVCPGFISTPLASNYFRNEEFKKEVENIIPTGRVGEANEVSSLVAYLCLPAASYVTGQTICVDGGFSVNGFTFKSLPLR
What is the function of this protein?
Oxidoreductase having both tropinone reductase I and II activities.  Involved in the tropane alkaloids calystegines and cochlearine biosynthesis.  Can use tropinone and nortropinone as substrates and produces both tropine and pseudotropine.  Able to oxidize pseudotropine in the reverse reaction.
What are the official names of this protein?
Tropinone reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family. SDR65C subfamily.
Protein: MUTH_SHEAM
Sequence: MNTPLPPQSLDELLRRAKMMAGLSLGQLAAGLGWPVPANLKRDKGWIGQLIEQELGATAGSRPEQDFLHLGVELKTIPIDRSGKPLETTYVCVAPLMDTHGLRWEQSLVKHKLERVLWVPVEGERDIPVADRRIGTAILWQPTPQQSASLRQDWEEIMEFIALGKVHRLSARHGEVLQLRPKAANAAAKTECIMEDGTVGLTNPRGFYLKIPFTQAILRQAFDY
What is the function of this protein?
Sequence-specific endonuclease that cleaves unmethylated GATC sequences.  It is involved in DNA mismatch repair.
What are the official names of this protein?
DNA mismatch repair protein MutH, Methyl-directed mismatch repair protein.
What is the protein family that this protein belongs to?
Belongs to the MutH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIDHC_BACTN
Sequence: MPSKKETLTVIVIMALFLLLTAACIGLRSEHLLMAALYLVLFFAGLPTRKLAVALLPFAIFGISYDWMRICPNYEVNPIDVAGLYNLEKSLFGVMDNGVLVTPCEYFAVHHWAVADVFAGIFYLCWVPVPILFGLCLYFKKERKTYLRFALVFLFVNLIGFAGYYIHPAAPPWYAINYGFEPILNTPGNVAGLGRFDEIFGVTIFDSIYGRNANVFAAVPSLHAAYMVVALVYAIIGKCRWYVIALFSVIMAGIWGTAIYSCHHYIIDVLLGISCALLGWLFFEYGLMKIRGFRNFFDRYYQYIK
What is the function of this protein?
Catalyzes the addition of a phosphorylinositol group onto dihydroceramide to form phosphoinositol dihydroceramide (PI-DHC), an essential step in sphingolipid biosynthesis.
What are the official names of this protein?
Phosphoinositol dihydroceramide synthase, PI-DHC synthase.
Protein: CDC4_YEAST
Sequence: MGSFPLAEFPLRDIPVPYSYRVSGGIASSGSVTALVTAAGTHRNSSTAKTVETEDGEEDIDEYQRKRAAGSGESTPERSDFKRVKHDNHKTLHPVNLQNTGAASVDNDGLHNLTDISNDAEKLLMSVDDGSAAPSTLSVNMGVASHNVAAPTTVNAATITGSDVSNNVNSATINNPMEEGALPLSPTASSPGTTTPLAKTTKTINNNNNIADLIESKDSIISPEYLSDEIFSAINNNLPHAYFKNLLFRLVANMDRSELSDLGTLIKDNLKRDLITSLPFEISLKIFNYLQFEDIINSLGVSQNWNKIIRKSTSLWKKLLISENFVSPKGFNSLNLKLSQKYPKLSQQDRLRLSFLENIFILKNWYNPKFVPQRTTLRGHMTSVITCLQFEDNYVITGADDKMIRVYDSINKKFLLQLSGHDGGVWALKYAHGGILVSGSTDRTVRVWDIKKGCCTHVFKGHNSTVRCLDIVEYKNIKYIVTGSRDNTLHVWKLPKESSVPDHGEEHDYPLVFHTPEENPYFVGVLRGHMASVRTVSGHGNIVVSGSYDNTLIVWDVAQMKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIWNNGECSYATNSASPCAKILGAMYTLQGHTALVGLLRLSDKFLVSAAADGSIRGWDANDYSRKFSYHHTNLSAITTFYVSDNILVSGSENQFNIYNLRSGKLVHANILKDADQIWSVNFKGKTLVAAVEKDGQSFLEILDFSKASKINYVSNPVNSSSSSLESISTSLGLTRTTIIP
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.  Recognizes and binds to phosphorylated target proteins.  Directs ubiquitination of the phosphorylated CDK inhibitor SIC1.  Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus.  Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle.  It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation.  Required for HTA1-HTB1 locus transcription activation.  Required for G1/S and G2/M transition.
What are the official names of this protein?
Cell division control protein 4, E3 ubiquitin ligase complex SCF subunit CDC4, F-box protein CDC4.
What are the subcellular locations of this protein?
Nucleus.
Protein: Y6475_DICDI
Sequence: MKYGVKYEIDQSIPNDLPDFPFIDEKDYPSERWEITLKDQDTIIFSFNFLYIGKFLNEIKRYCKNRIITFETNIPKENNFYLLYHFIIWKNKNNWCEDSKVLIFKNSMIFIFCETRIKIDIDNNEIIIKSNPKTDTTLELKMSKFLENLKEKPLQVKNYYYFFTILSKVSNSVLINDDGFDIWIYSLEYPLFIIAKNGTGKTRFLKKVFTNSGILKCKQSIYLNEFMVLSFSNGVNNEEVKFFEEFLNVYKAHSMLSTLNNKGFLTKYIWNSINEVLKSNNLPFSLLPSDLKSDRLLFKMDDVTLYYHDLSSGEKTLFIVFALIVFYQDNYSGIADEEVLLLLDEIETTLHAQSLRVLFNAIHKQRNNLKIIMSTHNSTSLRIASEYGFHYYLLEKSLTISDGNSVKIKELKSHENAISYVSDGMLSVVDSSKLVFVEDDDDSKFYEIAYKKLFNYPHTTRLVFCNAGIKNNSQHDLNQVSLILKKMDGNDENVKSIQKLINTLKETNTIGGKTSVKEKVKLLSEKSVTEESFRLGNSQIIGLLDKDDGKNEGEFLITIDYYSYEMFLCSPLVLFYMIKNEFLKTSPDSHLSTITTTTPSSQEINTNLSQQDMVCFVIEKLIEKEVETKNRETNKTWKEYLDIFYEGIRSTTLFDVKLENQAIIKVPEIFINGFGKKGKGHNLFDTLVRIFAFGLNMQESTEKLKIKTLEAFEKMSTDNIPSCLRDTFLKVMNYSLKKITNNNNNNNNNNNNNKIKN
What are the official names of this protein?
Uncharacterized protein DDB_G0284767.
Protein: FDHD_CUPNH
Sequence: MMRCMQSPEVHPAAAGDAEPPTHSTFAVSRWRRGELMLSPDEVAEEVPVALVYNGISHAVMLATPADLEDFALGFSLSEGIVTRASDVYDIEIDTREHGIAVQLEIASEAFMRLKDRRRSLAGRTGCGLCGTESLEQVMRLPAPVRSDASFHTDVIQAAFVQLQLRQELQQHTGATHAAAWLRADGHVSLVREDVGRHNALDKLAGALASSGEDISSGAVLVTSRASYEMVLKTAAIGAGVLAAVSAPTALAVRLAEQASITLAGFVRAGAHVVYAHPQRLQHEASLA
What is the function of this protein?
Required for formate dehydrogenase (FDH) activity.  Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.
What are the official names of this protein?
Sulfur carrier protein FdhD.
What is the protein family that this protein belongs to?
Belongs to the FdhD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DAPB_HAEIG
Sequence: MTLKIAIAGAGGRMGRQLIQAVHSAEGVELGAAFERKGSSLVGTDAGELAGIGHLGVAVSDDLESQKDKFDLLIDFTRPEGTLEHIAFCVANNKKMVIGTTGFDENGKTAIKAASDKIAIVFASNFSVGVNLVFKLLEKAAKVMGDYCDIEVIEAHHRHKVDAPSGTALSMGEHIAKTLGRDLKTHGVFCREGITGERKRDEIGFSTIRASDVVGEHTVWFADIGERVEISHKASSRMTFANGAVRAGKWLENKANGLFDMTDVLDLNNL
What is the function of this protein?
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate reductase, HTPA reductase.
What is the protein family that this protein belongs to?
Belongs to the DapB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPR2_HUMAN
Sequence: MEVQVSQASLGFELTSVEKSLREWSRLSREVIAWLCPSSPNFILNFPPPPSASSVSMVQLFSSPFGYQSPSGHSEEEREGNMKSAKPQVNHSQHGESQRALSPLQSTLSSAASPSQAYETYIENGLICLKHKIRNIEKKKLKLEDYKDRLKSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKTFSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKTQLSKTESVKESESLMEFAQPEIQPQEFLNRRYMTEVDYSNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSWTTPMCEEQDSKQPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPNDQLLPRKLNTEPKDVPKPVHQPVGSSSTLPKDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAKGSEQGFQSPPASSSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVHSQETAANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFDTYRGLPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNSGDSGQGDSRSMTPVDVPVTNPAATILPVHVYPLPQQMRVAFSAARTSNLAPGTLDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMKNEEVLVSAYANDGAPDHETASNHAILQLFQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQD
What is the function of this protein?
Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581).  Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587).  May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity).  Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112).  May be involved in apoptosis (PubMed:14593112).
What are the official names of this protein?
Caprin-2, C1q domain-containing protein 1, Cytoplasmic activation/proliferation-associated protein 2, Gastric cancer multidrug resistance-associated protein, Protein EEG-1, RNA granule protein 140.
What is the protein family that this protein belongs to?
Belongs to the caprin family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm. SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm. SUBCELLULAR LOCATION: [Isoform 5]: Mitochondrion. Note=Colocalizes with aggregated mitochondria. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
Protein: RLMM_SHIBS
Sequence: MNKVVLLCRPGFEKECAAEITDKAGQREIFGFARVKENSGYVIYECYQPDDGDKLIRELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELLKFCRKFTVPLRAALRDAGVLANYETPKRPVVHVFFIAPGCCYTGYSYSNNNSPFYMGIPRLKFPAEAPSRSTLKLEEAFHVFIPADEWDERLANGMWAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFKFRPTRSNISWMVCDMVEKPAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYIQAQLDEHGINAQIQARQLYHDREEVTVHVRRIWAAVGGRRDER
What is the function of this protein?
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase M, 23S rRNA (cytidine2498-2'-O)-methyltransferase, 23S rRNA 2'-O-ribose methyltransferase RlmM.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR2_ACOCL
Sequence: MTKRYWNINLEEMMEAGVHFGHGTRKWNPRMAPYISAKRKGIHITNLTRTARFLSEACDLLFDAASGGKHFLIVGTKKKAADSVASAAIRARCHYVNKKWLGGMSTNWSTTETRLQNFRDLRAEQKAGKIDRLPKRDAAMLKRQLSTLQTYLGGIKYMTGLPDIVIIVDQQEDYTALRECVILGIPTICLIDTNSDPDLADISIPANDDAIASIRLILNKLVFAICEGRSSYIRNR
What are the official names of this protein?
30S ribosomal protein S2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GREA_STRT1
Sequence: MAEKTYVMTLAEKKQLEAELEEYKLVRRPEVVERIKIARSYGDLSENSEYEAAKDEQAFIEGQIQILETKIRYAEIVDSDAVANDEVAIGKTVVVQEVGTSDKDTYHIVGAAGADIFSGKISNESPIAQALIGKKVGDKVAIESPAGSYSVEILSVEKTS
What is the function of this protein?
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites.  The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes.  Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus.  GreA releases sequences of 2 to 3 nucleotides.
What are the official names of this protein?
Transcription elongation factor GreA, Transcript cleavage factor GreA.
What is the protein family that this protein belongs to?
Belongs to the GreA/GreB family.
Protein: RS6_TROWT
Sequence: MLGSPLREYELLVSLGSEFEPEAESRVRSLFTPVEPEGVTVKHLDVLGIRKFAYEIKGRNDGVCVVVRFLANAGSIAEIGRQMRLTEDVIRTKLLRVGRK
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: SELO_ECO24
Sequence: MTLSFITRWRDELPATYTALSPTPLNNARLIWHNTELANTLSIPSSLFKNGAGVWGGETLLPGMSPLAQVYSGHQFGVWAGQLGDGRGILLGEQLLADGTTMDWHLKGAGLTPYSRMGDGRAVLRSTIRESLASEAMHYLGIPTTRALSIVTSDSPVYRETVEPGAMLMRVAPSHLRFGHFEHFYYRREPEKVRQLADFAIRHYWSYLEDDEDKYRLWFSDVVARTASLIAQWQTVGFAHGVMNTDNMSLLGLTLDYGPFGFLDDYEPGFICNHSDHQGRYSFDNQPAVALWNLHRLAQTLSPFVAVDALNEALDSYQQVLLTHYGQRMRQKLGFMTEQKEDNALLNELFSLMARERSDYTRTFRMLSLTEQHSAASPLRDEFIDRAAFDDWFARYRGRLQQDEVSDSERQQLMQSVNPALVLRNWLAQRAIEAAEKGDMTELHRLHEALRNPFSDRDDDYVSRPPDWGKRLEVSCSS
What is the function of this protein?
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
What are the official names of this protein?
Protein adenylyltransferase SelO.
What is the protein family that this protein belongs to?
Belongs to the SELO family.
Protein: RL18_PECAS
Sequence: MDKKAARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAASTVEKAIAEQLKSTGNKDAATAIGKAIAERALEKGIKNVSFDRSGFQYHGRVQALADAAREAGLQF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: AURKC_HUMAN
Sequence: MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
What is the function of this protein?
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.  The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.  Also plays a role in meiosis and more particularly in spermatogenesis.  Has redundant cellular functions with AURKB and can rescue an AURKB knockdown.  Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'.  AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity.  Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
What are the official names of this protein?
Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3, ARK-3, Aurora-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
Protein: MRS2I_ORYSJ
Sequence: MAAAVVVAGEAAAAAAAAGAGGKKRGASRSWILFDAAGEERVLDADKYAIMHRVDINARDLRILDPLLSYPSTILGRERAIVLNLEHIKAIITAEEVLLRDPLDDNVIPVVEELRRRLAPSSATQHDVEGAEEDESPFEFRALEVTLEAICSFLGARTTELESAAYPALDELTSKISSRNLDRVRKLKSGMTRLNARVQKVRDELEQLLDDDDDMADLYLSRKLAGAASPVSGSGGPNWFPASPTIGSKISRASRASAPTIHGNENDVEELEMLLEAYFMQIDGTLNKLTTLREYIDDTEDYINIQLDNHRNQLIQLELFLSSGTVCLSLYSLVAGIFGMNIPYTWNDNHGYVFKWVVLVSGLFCAFMFVSIVAYARHKGLVGS
What is the function of this protein?
Magnesium transporter that may mediate the influx of magnesium.
What are the official names of this protein?
Magnesium transporter MRS2-I.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: ANKR9_HUMAN
Sequence: MPWDARRPGGGADGGPEASGAARSRAQKQCRKSSFAFYQAVRDLLPVWLLEDMRASEAFHWDERGRAAAYSPSEALLYALVHDHQAYAHYLLATFPRRALAPPSAGFRCCAAPGPHVALAVRYNRVGILRRILRTLRDFPAEERARVLDRRGCSRVEGGGTSLHVACELARPECLFLLLGHGASPGLRDGGGLTPLELLLRQLGRDAGATPSAAGAPASAPGEPRQRRLLLLDLLALYTPVGAAGSARQELLGDRPRWQRLLGEDKFQWLAGLAPPSLFARAMQVLVTAISPGRFPEALDELPLPPFLQPLDLTGKG
What is the function of this protein?
Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:30293565).  Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly (PubMed:30293565, PubMed:31337707).  Implicated in different cellular processes, like copper homeostasis and cell proliferation (PubMed:24522796, PubMed:30293565).
What are the official names of this protein?
Ankyrin repeat domain-containing protein 9.
What are the subcellular locations of this protein?
Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Detected in long filamentous cytosolic structures where it colocalizes with IMPDH2 (PubMed:31337707). Under basal conditions ANKRD9 is mainly in vesicle-like structures, upon nutrient limitation (guanine nucleotides deficiency) ANKRD9 loses its vesicular pattern and assembles with IMPDH2 into rodlike filaments (PubMed:31337707).