PharMolix/UniProtQA huggingface dataset:
Protein: VATC1_RAT
Sequence: MTEFWLISAPGEKTCQQTWEKLHAATTKNNNLAVSSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLASGVDLVTYITRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGSLLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSEDQDSYLCNVTLFKKAVDDFRHKARENKFIVRDFQYNEEEMRADKEEMNRLSTDKKKQFGPLVRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAMLLQPNKKSVKKLREVLHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK
What is the function of this protein?
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585).  V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32165585).  Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
What are the official names of this protein?
V-type proton ATPase subunit C 1, V-ATPase subunit C 1, Vacuolar proton pump subunit C 1.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase C subunit family.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein.
Protein: HEM3_SULIK
Sequence: MKIRIAARGSKLSRIQVDMLGEKLKKIGIEYEIIDIKTKADLFSTEPLSKLGKGVFEKEVNEAVLEGKADIAVHSMKDILSEINPSLEIFAVLERDPPYDILIAEKNLDKLDSNITIGTSSIRRKNFLKYIKPEINTKDIRGNVDTRIRKYLSKEYQGLILAEASLKRLNMTMNYHRLNVYDFTPEANQGIIVALGRKKDEKIKEIFKEINHKDTLDEALAERAVISLVGGGCHSPIGVLFKKEGKEFYGIASYSDGKKKITVSISKPGDPYTIGSELGLLLKKEMKNEDIIP
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Probable porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: TPIS_CLOTE
Sequence: MKGVYGLRKAIIAGNWKMHNTIDESVKLVEELIPKVKEAECEVVVCPPFICLPKIREITEGTNIKVGAQNMYFEEKGAFTGEVSPLMLEKLNIDYVIIGHSERRQYFKETDQTVNKKLKAAFEHNLIPILCVGETLDEKENGVTEEVVSKQVKLGLFELKEEQVEKLVIAYEPIWAIGTGKTATSEEANEVIALIRSTVKSLYGDKVAESLRIQYGGSVKPSTIKEQMSMSDIDGALVGGASLKANDFSAIVNYK
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPF_COLP3
Sequence: MRIGHGFDVHKFGGKGPLVLGGVKIPFELGFIAHSDGDVAIHALCDAILGALCLADIGNHFPDTDGQYENISSRILLRHVVSLMTDKGFQLGNADITIVAQAPKMAPHLVAMRTCLSEDLKTTIEQVNVKATTTEKLGYTGRKEGISVHAVVLLIAIEHPLPLIEEIQNI
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: LECM2_BITAR
Sequence: MGRFIFVSFGLLVVFLSLSGIGADQECLPGWSFYEGHCYKVFDEYKNWTDAEQYCTEQENGGHLVSFHNREEVDFVVKLGYTILKADIVWIGLRDFWRECHWGWSNGAQLDYKGWNDEPNCFIAYTVGNKWLRRKCSSTQQFVCKSPA
What is the function of this protein?
Mannose-binding lectin which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids.  May be a calcium-dependent lectin (By similarity).
What are the official names of this protein?
C-type lectin 2, CTL-2.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: 3SBB_HEMHA
Sequence: LKCKNKVVPFLKCKNKVVPFLCYKMTLKKVTPKIKRG
What is the function of this protein?
Hemextin AB complex: specifically inhibits the activation of FX (F10) by the TF-FVIIa complex (extrinsic tenase complex (ETC)) (IC(50)= 100 nM, Ki=50 nM) by non-competitively inhibiting the enzymatic activity of FVIIa.
What are the official names of this protein?
Hemextin B, Hemachatus extrinsic tenase inhibitor B.
What is the protein family that this protein belongs to?
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type IB cytotoxin sub-subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RSMH_COREF
Sequence: MDDYSIAGNHGHVPVMRDRMAALIADHVREMGDRAVIVDATLGAGGHAEHFLTVFPEAHVIGLDRDENALRDAGERLARFGDRFLGVKTRFDGLSQVLATGEGDILDLARKEGISGALFDLGVSSMQLDQVERGFAYRTDAPLDMRMDPTQGITAADILNTYSHGDIARVLKTYGDERFAGKIASAVLKEREKEPFTTSARLVELLYDTIPAATRRTGGHPAKRTFQALRVEVNRELESLSNVLPQITDALNVGGRAVFMSYQSHEDKLVKRFFTELTTSKTPPGLPVDLPGTAPRFRQVTRGAETASEAEIEENPRAAPVKVRAIERIAEHTENTEN
What is the function of this protein?
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase H, 16S rRNA m(4)C1402 methyltransferase, rRNA (cytosine-N(4)-)-methyltransferase RsmH.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RsmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MDM1_YEAST
Sequence: MPKFPQFRLILVLFYLISMIQWSVITFSLGFFLNVCIFAYFVFFKSLPDLPKPQPRFVDIVPESSNTVDVDKELKSVEGLIQDGNAQIGKELESIVNLIIKDFVQPWFTKIDKNSDAEFLKVIKWRLLQTLLVVKDKLMKNDSASLIVLKLLPIFNKHFSTFCDAREAVLSDLTLERHKSANIDLQIAVEFNKNYKIHKSLSLKPNALQKEIEKSIRKTVIGLLPHLFDNDELDSLLVFTLMTEVLTTCIISPLIFKFTDPDSWNLRIVSLSQNYFEEKHKVHKIRRMLSKELQDHRKVMNDVANKDVGEPSSEKLELNAEYTGKQFEHYLNQLDSLLDLSDIKYVAYSLALKIYQLKENEHLTKENLKYKKRLLLSLNLIESKLSFPGSEIDTASKKLAREANYPDLNMDNGIVLKEMASFLTSITLKDIVDDSEFLPFFESFLGSVPETQGSTFLEYSQTIESFKNPLEDATSEDIISGYSGISTMQLQEISSKFFHNNNLQNMKLLDEGLVKNIILFRNSFQINNDEDTFILARKSVLLLQTEAIKYLDDRFLPLFKKTPSFLKMLSTSHIISTDIYAHFLSRIGGVNNPEQNKIIKDNVKTDFMNPVRIFANPGITDALDNIVNGSGSKPHKSRISSNPRYSQLFGSENDNIFKDKLFDDENDNTSEISVVEDQLDHPRNMEKVSVSSGNSGLNPSQFYGSNNFRDNIASLTISIDQIEKELELLRHLILKADLTNNQMQLKILKKSQRTLLKELEMKELLKQQYMVQENGNSLFRKTKIYIRSYFSENSSNGLKEITYYIINIHHFNNGQVSSWDMARRYNEFFELNTYLKKNFRDLMRQLQDLFPSKVKMSLKYHVTKTLLYEERKQKLEKYLRELLSISEICEDNIFRRFLTDPTPFKLNKEYMHDDILEEPLHEPIGSSNSTSNSSSVVDLQSSEDGGELNFYEDERHFFTDSGYPFYSQNKSFVKQICDLFISLFALNKANAGWLRGRAIITVLQQLLGSTIEKYIKVSIQKLRSEDQVFEAIVTFKNMLWGDNGLFERKRNETAEATRSEGERLRTEQLALTSLQRLFADTCGRVVGLRDSHEAAGRVHAMLQNPYLNASLLLEALDAILLDIICND
What is the function of this protein?
Essential for mitotic growth.  Mediates organelle inheritance.
What are the official names of this protein?
Structural protein MDM1, Mitochondrial distribution and morphology protein 1.
What is the protein family that this protein belongs to?
Belongs to the sorting nexin family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LTOR1_BOVIN
Sequence: MGCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPVPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP
What is the function of this protein?
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.  Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag.  Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.  LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes.  Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes.  May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes.  May also play a role in RHOA activation (By similarity).  Involved in the control of embryonic stem cells differentiation; together with FLCN it is necessary to recruit and activate RRAGC/RagC and RRAGD/RagD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity).
What are the official names of this protein?
Ragulator complex protein LAMTOR1, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1.
What is the protein family that this protein belongs to?
Belongs to the LAMTOR1 family.
What are the subcellular locations of this protein?
Late endosome membrane; Lipid- anchor; Cytoplasmic side. Lysosome membrane; Lipid-anchor; Cytoplasmic side. Cell membrane; Lipid- anchor.
Protein: RS3_BARHE
Sequence: MGQKINPIGLRLGVNRTWDSRWYADSGEYGRLLHEDLKIRLYVLEELKQAAVSKIVIERPHKKCRVTIYSARPGLIIGKKGADIEKLRRKLSEMTNAETSLNIVEIHKPEIDATIIAQSIAQQLERRVAFRRAMKRAVQSALRLGAEGIRINCSGRLGGAEIARMEWYREGRVPLHTLRSDVDYGTAEAKTAYGICGVKVWVFKGEILEYDPMASERRAAEVDHSGSSSNRRRENA
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: MOG_ECO57
Sequence: MNTLRIGLVSISDRASSGVYQDKGIPALEEWLTSALTTPFELETRLIPDEQAIIEQTLCELVDEMSCHLVLTTGGTGPARRDVTPDATLAVADREMPGFGEQMRQISLHFVPTAILSRQVGVIRKQALILNLPGQPKSIKETLEGVKDAEGNVVVHGIFASVPYCIQLLEGPYVETAPEVVAAFRPKSARRDVSE
What is the function of this protein?
Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor.
What are the official names of this protein?
Molybdopterin adenylyltransferase, MPT adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MoaB/Mog family.
Protein: KCNA5_HUMAN
Sequence: MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
What is the function of this protein?
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.  Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient.  The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.  Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714).  Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714).  Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714).  May play a role in regulating the secretion of insulin in normal pancreatic islets.  Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461).
What are the official names of this protein?
Potassium voltage-gated channel subfamily A member 5, HPCN1, Voltage-gated potassium channel HK2, Voltage-gated potassium channel subunit Kv1.5.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CL20A_HUMAN
Sequence: MLPRALLLSFCAAALQLVSSKRDLVLVKEALSWYDAQQHCRLHYTDLADLQPSGLWKLYSLMTSTPAWIGLFFDASTSGLRWSSGSTFTALEWGQKLPEFGVGFCATLYTWLKLPSIGAASCTAQKPFLCYCDPDVGHLISTKPSLSLTTSPKPAVVQISGQTFMRFDQVMTWSSALLYCRSHHTDLADLQMVTDETGKEALRSIMSETEAWIGLYLNANSGSLSWSSDLGASIPSWLQVPMMVRGLCTALGIYMTYSPKVYSVNCSSLLPFFCFYDSSTGHRASAELPPLFHTSPTEMTEETTPRPGRAVASVGSGTDRRDTAAATEAQHLSSESKEKTSAQKSGHPFGILKADFTISTLMDPEEMKDQFLRQIQEVLKLTLGHEQFRLKWVSFEVNKK
What are the official names of this protein?
Putative C-type lectin domain family 20 member A.
Protein: SYY_XANAC
Sequence: MTTIEESLALIGRGTEEILKLDQLQARLATGKPLRVKAGFDPTAPDLHLGHTVLLNKMRQFQQLGHQVIFLIGDFTGMIGDPSGKNATRKPLSREDVLANARTYEEQVFKILDRERTEVRFNSEWFGQMSAADMIKLSAQHTVARMLERDDFAKRFGSQQPIAIHEFLYPLVQGYDSVALKADVELGGTDQKFNLLMGRGLQEHYGQAPQIVLTMPLLEGLDGVAKMSKSLGNYIGINEPAIDIVTKTMKIGDALTWRWIDLLSFDISMAEAARLKEEVASGELHPREVKLRLARELATRFHDAATAEQAIAGWHAVVTGQGDTGLLPLQEVVVPAEGLRLAGLLTAAGLTPSNSEATRKLKERAVKIDGEVVEDPGRVFTQGFEGVIQVGKRNFARVSLVTG
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_POLNA
Sequence: MLIHPEINPVALQLGPLAIHWYGLTYLAAFGLFFFLASLRLRHEPYASITGPGAWSRRDIEDILFLGVMGVVIGGRLGYCLFYKPGYYLTHPLEIFAVWQGGMSFHGGMLGVLVSQWWFARSRQRPWLQVMDFIAPCVPTGLAAGRVGNFINGELWGRFSAPDLPWGMVFAHSGSMLPRHPSQVYQFLMEGLLLFVLLWLYARKPRKMGQVSGAFLVGYGVFRFIAEFFREPDDFLGILALGMSMGQWLCVPMIAAGIWLWIWASNRTSRR
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYFA_CHLTR
Sequence: MTIQEELEAVKQQFSCDVSLAHSSKDLFDVKVKYLGKKGIFRGFADQLRKYPIEQKATVGASINACKQYVEEVLLERGKAVLAKEEAEEFLKEKIDISLPGSEEAALGGKHVIKKVLDDVVDIFVRFGFCVREAPNIESEKNNFSLLNFEEDHPARQMQDTFYLDPTTVLRTHTSNVQSRELARNKPPVRIVAPGECFRNEDVSARSHVIFHQVEAFCVDKDISFSDLTSMLAGFYHIFFGRKVELRFRHSYFPFVEPGIEVDISCECHGAGCSLCKHAGWLEVAGAGMIHPNVLRKASIDPEEYSGYALGMGIERLAMLKYGISDIRLFSENDLRFLRQFS
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDSA_VIBVU
Sequence: MMEQKIVQIGDIPVANDKPFTLFAGMNVLESRDLAMQICEHYVKVTDKLGIPYVFKASFDKANRSSVHSYRGPGLEEGMKIFQELKDTFGVKIITDVHTEAQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFMSPGQVGNIVEKFAECGNDKIILCERGSCHGYDNLVVDMLGFGVMKKASKGSPIIFDVTHSLQMRDPSGAASGGRREQTVELAKAGLATGIAGLFIEAHPNPDQARCDGPSALPLDKLEPFLAQMKALDDLVKSFASIDIR
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENV_FLVC6
Sequence: MEGPTHPKPSKDKTFSWDLIILVGVLLRLDAGMANPSPHQVYNITWTITNLVTGIKANATSMLGTLTDTFPTIYFDLCDIIGNTWNPSDQEPFPGYGCDQPMRRWQQRNTAFYVCPGHANRKQCGGPQDGFCAVWGCETTGETYWKPTSSWDYITVKKGVTQGIYQCNGGGWCGPCYDKAVHSSTTGASEGGRCNPLILQFTQKGRQTSWDGPKSWGLRLYRSGYDPIALFSVSRQVMTITPPQAMGPNPVLPDQKPPSRQSQIESRVIPHHPQGNGGTPGITLVNASIAPLSTPVTPASPKRIGTGNRLINLVQGTYLTLNVTNPNKTKDCWLCLVSRPPYYEGIAVLGNYSNQTNPPPSCLSVPQHKLTISEVSGQGLCIATVPKTHQALCNKTQKGHRGTHYLVAPNGTYWACNTGLTPCISMAVLNWTSDFCVLTELWPRITYHEPEYIYSHFENKPRFKRDPISLTVALMLGGITVGGMARNRNRDCGLLETAQFRQLQMAMHTDIQALEESISALEKSLTSLSEVVLQNRRGLDILFLQEGGLCTALKEECCFYADHTGLVRDNMAKLRERLKQRQQLFDSQQDGLEGWFNKSPWFTTLISSIMGPLMILLLILLFGPCILNRLVQFVKDRISVVQTLVLTQQYQRLGQWRLRPTVSPQLNV
What is the function of this protein?
The transmembrane protein (TM) acts as a class I viral fusion protein.  Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state.  During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain.  The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.  Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm (By similarity).
What are the official names of this protein?
Envelope glycoprotein, Env polyprotein.
What are the subcellular locations of this protein?
[Transmembrane protein]: Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: [Surface protein]: Virion membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein. Note=The surface protein is not anchored to the viral envelope, but associates with the extravirion surface through its binding to TM. Both proteins are thought to be concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag (By similarity). SUBCELLULAR LOCATION: [R-peptide]: Host cell membrane; Peripheral membrane protein. Note=The R-peptide is membrane-associated through its palmitate.
Protein: O10A7_HUMAN
Sequence: MICENHTRVTEFILLGFTNNPEMQVSLFIFFLAIYTVTLLGNFLIVTVTSVDLALQTPMYFFLQNLSLLEVCFTLVMVPKMLVDLVSPRKIISFVGCGTQMYFFFFFGSSECFLLSMMAYDRFVAICNPLHYSVIMNRSLCLWMAIGSWMSGVPVSMLQTAWMMALPFCGPNAVDHFFCDGPPVLKLVTVDTTMYEMQALASTLLFIMFPFCLILVSYTRIIITILRMSSATGRQKAFSTCSSHLIVVSLFYGTASLTYLRPKSNQSPESKKLVSLSYTVITPMLNPIIYGLRNNEVKGAVKRTITQKVLQKLDVF
What is the function of this protein?
Odorant receptor.
What are the official names of this protein?
Olfactory receptor 10A7, Olfactory receptor OR12-6.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: AOC2_MOUSE
Sequence: MNLKVLLLLLGLSFLTVFALVYVLLTRQGSFSQSPRCPSIPPRIHPWTHPSQSQLFADLTPEELTAVMSFLTKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPMQKTEFVQIWRHLKEVELPKAPTFLASVLNYNGSTLAPLHSTASGFHAGDRATWIALYHNISGLGVFLHPVGLELLLDHGALDPADWVVQQVFYLGHYYADLAQLEWEFKVGRLEVIRVPLPTPGGASSLRPRVTPDPPLPPLQFSLQGPQYNIQGNSVTSPLWTFTFGHGVFSGLRIFDIRFKGERVAYEVSVQECLTVYGADSPKTMTIRYLDSSYGLGLNSRALVRGVDCPYQATMVDIHVLVGTGSVQLLPGAVCVFEEAQGLPLRRHHNGIGGHFYGGLASSSLVVRSVSSVGNYDYIWDFMLHPTGALEARVHATGYINTAFMSGGAESLLFGNRVGERVLGAVHTHAFHFKLDLDVAGLKNWVIAEDAVFKPVAAPWNPELQLQRPQLTRQVLSREDLAAFPWGSPLPRYLYLATNQTNAWGHQRGYRIQIHSPPGVHVPLESSEERALSWGRYQLVVTQRKEAEPHSSSIYYQNDMRSPATVFADFINNETLLGEDLVAWVTASFLHIPHAEDIPNTVTVGNRVGFLLRPYNFFNEDPSIFSPGSVYFERDQDAGLCSINPVACTQQLADCVPNLPSFSYEGL
What is the function of this protein?
Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine.  May play a role in adipogenesis.  May be a critical modulator of signal transmission in retina (By similarity).
What are the official names of this protein?
Retina-specific copper amine oxidase, RAO, Amine oxidase [copper-containing].
What is the protein family that this protein belongs to?
Belongs to the copper/topaquinone oxidase family.
Protein: METK_METM5
Sequence: MANIVVKRLERTPIDETPVEIVERKGIGHPDSICDGIAESVSVALCKMYKEKMGVVLHHNTDQVELVGGYAYPELGGGCMVSPIYVLLSGRATMEVLDKKSGKIIKLPVNTTAVNAARDYLKKAIRNMDLEKDVVVDCRIGQGSVDLVEVFDRKRSEIPHANDTSFGVGHAPLSTTEKIVLETEKLLNSDALKAEIPAVGEDIKVMGLREGKKITLTIAMAAVDKYVNSCADYVKVKELAKAKVEENAKKYLDSHELEVCINTADDDEDCIFLTVTGTSAEMGDDGSVGRGNRANGLITPFRPMSMEATSGKNPINHIGKIYNILSNIIAEDVAKIEGVRECQIRILSQIGKPITEPKILDIEMIPENGFELEELSPKAKEVAQKWLENISEVTERIVSGNVTTF
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase 2 family.
Protein: YTFE_ECO24
Sequence: MAYRDQPLGELALSIPRASALFRKYDMDYCCGGKQTLARAAARKELDVEVIEAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKVERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMGPISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDLMDHISLENNVLFPRALAGE
What is the function of this protein?
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
What are the official names of this protein?
Iron-sulfur cluster repair protein YtfE.
What is the protein family that this protein belongs to?
Belongs to the RIC family. YtfE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPPA_PSYA2
Sequence: MDIILASGSPRRRELLSRAQLEFTIISVDIDETPYQDELPKDYIVRMVAAKAEAAATQLNIQLKNNEAHSSKSLLSQPIILLTSDTIGVLPDGKTVLIKPSNREDAYHMWQQMSDSTHEVWTAVQATQLSLHSKHTDEFDTEPVWQIINQKQIIERTEVTFIALTPEMMSDYWDGGEPADKAGGYGIQGLGAAWVSRINGSYTNVVGLPLAQTLALIKEMTNTAMLENFDA
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.