PharMolix/UniProtQA huggingface dataset:
Protein: UBC_MOUSE
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSVTTKKVKQEDRRTFLTTVSKKSPPCACSWV
What is the function of this protein?
Exists either covalently attached to another protein, or free (unanchored).  When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains).  Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B.  Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.  Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed.  When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
What are the official names of this protein?
Polyubiquitin-C.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin family.
What are the subcellular locations of this protein?
[Ubiquitin]: Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein.
Protein: PKS1_METRA
Sequence: MNHVTIKQSDTRADPFRVFIFGDQSSCNLSNLQLLLFKKSNVYLASFIDQVNLTLRHEIARLTAAERQSFPAFSSVQNLVARALKKDTSVALESTLATIYHLCCFINYFGDGQEAYPTGPTTHVSGLCIGALAAAAVSSSKSLAELVQAGIDAVRVSLKVGLLVARTAALFSHQESNGTSSSPWSYALPDSQLPLALAEEAIESYQAKTNIPPLSLPYISAKGQNSWTVSGPPAIVQHFLETSQFEKTLRLTPLAVHAPYHAPHIFSAIDVQHIIRAVGPVSSFSSKLSFISSSSSRNLPTGLKFQDLLYRAVEDILILPLDLREAAENIRLVLEATDNVQQCALFPISTGVGPSLKQSFSPAMASRVSIVDCIMERVAADAGPKSTSGPKPSESKIAIIGMSGRFPESADVEAFWDLLHQGLDVHRPVPPDRFNGELYYDVTGKRKNTCKVMHGCWINDPGLFDAKFFNISPKEAEQSDPGQRLALATAYEALEAAGVVADRTPSTQRDRVGVFYGMTSDDYREVSCGQNVDTYFIPGGNRAFTPGKINYFFKYCGPSVSVDTACSSSLAAIHLACNSIWRNECDTAIAGGTNVMSNPDSFVGLDRGYFLSRTGNCHTFDDDADGYCRADAVGTVILKRLEDAIADHDPILGVISGALTNHSADAVSITRPHSGAQEEIFSKLLTESGVHPHQVSYIEMHGTGTQAGDATEMTSVLNCFAPSTSPRRLPHESLHLGSTKANVGHSESASGVSALIKVLLMMEKNIIPPHCGIKGKINHKFPTDLDERNVHIAKTATQWNRRNELNNIRRAFVNNFSAAGGNTALLVEDYPLRIADSAQQDARTAHVVTVSAKSIKSLKGNLENLKKFVQKQAFTEGFLPKLSYTTTSRRMHHPFRVAIPAANSEQLLCALDEELKHDSYTCSSESPVAFVFSGQGSQYSAMGQHLLHFTIFRDEVHAYDILAQRHGFPSIMPLIDGSVDIEDLEPLVVQLGTVCVQMALASLWMALGMRPAYVVGHSLGHYAALKVAGVLTASDTIYLVAMRARLLQNKCSRGSHAMLAIRSSAAEIQAHLDEGIHDIACINGPQDTVVSGCIDDIDRLSQKLMDKGIKATRVNVPFAFHSAQVDPILDELEAIASQVEFHAPRVAIGCPLLGKTFTAGETPSLEAKHIRRHCRETVNFLDVLRSAKDDGFVSEKTAWIEIGPHTVCSNLVKANINQDITAVPSLMRNKDGWQVLASSVATLYRHGLSVAWDEYHHDFEACKQVLRLPAYSWDNKLYWIDYVHDWLLTRGDPPVQAAAPLPAPPSSFSTASVHRMVHESVEKGKLTLTAECEFTNEQLREVVYGHVVNGNRVCSSSLYTDFGVTLGSYILEKYRPDLQGHAVDVQDMVVNKALVHKEGPTMLLRIDVVLDTTDSKAASMSIYSVNSKGNKTADHAQSSLHFEQPKVWLKSWDSTQYYVERSIEWLKEKADQGLNSRMSSGVIYKLFSSLVDYSTAYKGMQEAIVNTEDFEATALVRFQVDEGNFRCNPMWVDSCGQLAGFLMNGHAKTPKDQVFINHGWQYFRTVRKFSRDKTYRTYVRMRCVEGTTYAGDVYIFDDEGIVGVCGSITFQGIPRKVLNTAMPPPKSQNEAPVRSGPAKPAAKPPRSASSEHSGHFARHANIEPLKLDAALKSATTARNPMLPVFKIVAEEIGIPSASVDNGLVFADYGVDSLLSLSISGRLREELDLDVESSAFETCATLADLAAQLGLDTFSSDQSSGQSSSSGGLSPRSDSIGEITSSVTTPPSLSPRGSVSGSQCKDVCAILAEEIGVSMGEITNDTDLGALGMDSLMSLAVLSRLREELELDLEGDFFVSHPNFSSFKHMFQQGHGDEVEPEPSAELKQYRATSTLLQGNPKSALYTLFLLPDGSGSSFSYAPINAVRKDVCVFGLNCPWLKSAEKLVQFGLKGLATLYVEEIRRRAPHGPYNLGGWSAGGICAYEAAIQFTREGETVERLILLDSPNPIGLEKLPARLFDFVNGLGLFGDGKAPDWLLAHFLAFIDALDEWKPVPWDKALGGNSPPPMTYILWAEDGICKGTDARPEYRDDDPREMKWLLENRTNFGGNNWDVLLGQQSLSIERIQDANHFTMLRKGKNTERVAAFIRSTFG
What is the function of this protein?
Polyketide synthase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress (PubMed:25445307, PubMed:28447400, PubMed:29958281).  The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA (PubMed:29958281).  The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment (PubMed:20382249, PubMed:25445307, PubMed:28447400).
What are the official names of this protein?
Polyketide synthase 1, Conidial pigment biosynthesis polyketide synthase.
Protein: TBCC1_CHICK
Sequence: MAAAVSLWPRTEPLLLGALPVPPPARLGPHYLRKMAAYARARAAEGCYPRLSWPRWRHIACGKLQLGRGLAWLYFERFHDLLPPPDPPRRLQRAEAEAACGSAEELERERGKLSVDTLRFLLFLYLQQLNKASLRTSLIGEEWPSHRARAAGLPGRAAGQSKNWNDQDHLAFLLTHLSDMLELLLEPEQLGASSHATHNSLVSYEAVCALSFLIEGTVNNSRTIHPLHELALWQPCHGQNGYSKISKTFSFPKLENWLRSCLIINPFGMTACLRSGKKLAWAQQVEGTTRRAKIACNTRVVPEVSPMVIMSQVYKQTLAKSSDTLVGAHVRIHRCNESFIYLLSPLCSVTIEKCRNSTFVLGPVEASVHVHSCDNIKVITVCHCLSLSSTTGCTFHILTPTQPLILAGNQAISFAPFHTHYPMLEDHMAQVGLATVPNYWDSPMMVCKEGSDASVFRLLSPLDFYTFVIPFEMEGDTTETPGGLPHAYQKALNQREQKVQIWQKMVKEACLTKDQRKQFQMLVESKFYEWLIQTGNRQQLDSLVPPAVGSKQAAG
What is the function of this protein?
May play a role in the regulation of centrosome and Golgi apparatus positioning.
What are the official names of this protein?
TBCC domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the TBCC family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Protein: HSCA_ACIET
Sequence: MALLQISEPGQSPDPHQRRVAIGIDLGTTHSLVAAVRNGVAECLPDAQGRVLLPSVVRYLGGGGRQIGYEAAAAQMQDPANTVSSVKRFMGRGLGDITGREKLPYDFIAAADSGGMLSLSTAAGVKSPVEVSAEILATLRYRAEDSFDSDLYGAVITVPAYFDDAQRQATKDAAHLAGLNLLRLINEPTAAAIAYGLDNGAEGVYAVYDLGGGTFDISVLRLAQGVFEVIATGGDSALGGDDYDAALAEWVMQQTGVRASTPEDKTSVRLAARACKEALTATDNVAFTADVAGATVQFDVKREDFAAVTAELTQRSLAAVRRTLRDAQIERDEVKGVVLVGGSTRMPVVRAAVAEFFGREPLTNLNPDEVVAIGAAIQANQLAGNDAAGDLLLLDVIPLSLGIETMGGLVERIIGRNETIPTAKAQDFTTYKDGQTALAIHVVQGERDLVQDCRSLARFELRGIPPMAAGAARIRVTFTVDADGLLSVAAREQASGVEARIDVKPSYGLSDEQIARMLQEGFATAQQDMQTRALVEARVDADRLLIATQSALDVDGDVLAAAERTAIDDLMHALRATLETSTDAAAVEAAAQALAKGTEAFAAQRMNRGIRQALAGKNVSAL
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: TTCA_ROSDO
Sequence: MLDHSDEIHPLFHGAPKTTEFRKLRKRLVRQTRDAIERYGMIEKDARWLVCLSGGKDSYTLLAVLYELKWRGLLPVELLACNLDQGQPGFPATVLPEFLKKMEVPHRVEYQDTYSIVMDKVPQGRTLCALCSRLRRGHLYRIAREEGCSAVVLGHHRDDILETFFMNLFHGGRLATMPPKLVNEEGDLFVYRPLAHVSEADCDRFSTAMGYPIIPCDLCGSQDGLQRQQVKAILEGWEKNSPGRRQVMFKALMNTRPSHLLDTALFDFAGLARK
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DPO4_METMJ
Sequence: MTTGSRIVLHVDMDSFFASIEVRRDPSLAGRPVIVGADPKGGAGRGVVSTCSYEARRYGVHSGMPISRAFDLCPHGVYLPVDRPFYASVSVEIMALLSRHAGRIEQVSIDEAYLDVSDAGSFPAAGALAAAIKREVREETGLTCSVGVAPGKAVAKIASDFQKPDGLTIVRPDEVAGFLASLPVGRIPGIGKKTGEDLRQAGILTVGDLARRDVQEVIARLGRSGVRVHHLARGIDDGEVQGREGCKSISRETTFEADTADPPVLAGTLAELADDVAETLRADNLRCRTVTVKVRYRGFQTHTRSRTLPRFTSDPETIRRAASGLLLPFLNGEPVRLIGVRLSMLEGGCTRQASIDEFFS
What is the function of this protein?
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis.  Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends.  These misaligned primers can be extended by PolIV.  Exhibits no 3'-5' exonuclease (proofreading) activity.  May be involved in translesional synthesis.
What are the official names of this protein?
DNA polymerase IV, Pol IV.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-Y family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PIMT_SHEWM
Sequence: MSRVATTAALNLAKSLRDAGIRDEAVLQAVANTPRELFLDAALGHKAYENTALPIGMGQTISQPYIVARMTELLLEHKPKKVLEIGTGSGYQAAILAQLSPELCTVERIKSLQIQARQRLKRLDLHNISFKYGDGWKGWPNKGPFDAIMVTAAAATVPEALLGQLVDNGVLIIPVGDTSQQLLKVVRHGEQFSSEVVEIVRFVPLVNGELA
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CA14B_CONQU
Sequence: SDGRNTAANDKASDLMALRDGCCPNPSCSVNNPDICGGGR
What is the function of this protein?
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity).  Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity).
What are the official names of this protein?
Alpha-conotoxin-like Qc1.4b.
What is the protein family that this protein belongs to?
Belongs to the conotoxin A superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: GLMU_HAEI8
Sequence: MTKKALSAVILAAGKGTRMYSDLPKVLHTIAGKPMVKHVIDIAHQLGSENIHLIYGHGGDLMRTHLANEQVNWVLQTEQLGTAHAVQQAAPFFKDNENIVVLYGDAPLITKETLEKLIEAKPENGIALLTVNLDNPTGYGRIIRENGNVVAIVEQKDANAEQLNIKEVNTGVMVSDGASFKKWLARVGNNNAQGEYYLTDLIALANQDNCQVVAVQATDVMEVEGANNRLQLAALERYFQNKQASKLLLEGVMIYDPARFDLRGTLEHGKDVEIDVNVIIEGNVKLGDCVKIGAGCVLKNVVIGNDVEIKPYSVLEDSIVGEKAAIGPFSRLRPGAELAAETHVGNFVEIKKSTVGKGSKVNHLTYVGDSEIGSNCNIGAGVITCNYDGANKFKTIIGDDVFVGSDTQLVAPVKVANGATIGAGTTITRDVGENELVITRVAQRHIQGWQRPIKKK
What is the function of this protein?
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc).  The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
What are the official names of this protein?
Bifunctional protein GlmU.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSG1_YEAST
Sequence: MGKKKSKNQLNTGGVPNGVHNTKKEAALPPLGNKLGSASFTAINTLTKPALFSFYDDDITKNEGNVYDKALLSNASQLEMVPPSATARHERSLYAKIINTIAAFFILFIAGILFPMISECLFDNDQLAKGDIVSFLKHGIEIKNKIVAEPDMVPDWAVFGTEGVIFGSIVPFIDSFVRYQHQPKTRSSVYKNTLGSFIRCANTLLGLIFGIRKLEWSSSLQAAGAWSLLNIVLWLFFDGTLTVFFPGLVIGALSAFTCSQCFSQLSLALYFIDFYFFGFLMFSKLGRYLFN
What is the function of this protein?
Stabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation.  Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation.
What are the official names of this protein?
Protein NSG1, INSIG homolog 1.
What is the protein family that this protein belongs to?
Belongs to the INSIG family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: MOT13_HUMAN
Sequence: MARRTEPPDGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALSLHLVACGALLRPPSLAEDPAVGGPRAQLTSLLHHGPFLRYTVALTLINTGYFIPYLHLVAHLQDLDWDPLPAAFLLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSLALFPVAQAPTALVALAVAYGFTSGALAPLAFSVLPELIGTRRIYCGLGLLQMIESIGGLLGPPLSGYLRDVTGNYTASFVVAGAFLLSGSGILLTLPHFFCFSTTTSGPQDLVTEALDTKVPLPKEGLEED
What is the function of this protein?
Proton-linked monocarboxylate transporter.  May catalyze the transport of monocarboxylates across the plasma membrane.
What are the official names of this protein?
Monocarboxylate transporter 13, MCT 13, Solute carrier family 16 member 13.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein: DHML_METEA
Sequence: MLGKSQFDDLFEKMSRKVAGHTSRRGFIGRVGTAVAGVALVPLLPVDRRGRVSRANAAESAGDPRGKWKPQDNDVQSCDYWRHCSIDGNICDCSGGSLTSCPPGTKLASSSWVASCYNPTDKQSYLISYRDCCGANVSGRCACLNTEGELPVYRPEFGNDIIWCFGAEDDAMTYHCTISPIVGKAS
What is the function of this protein?
Methylamine dehydrogenase carries out the oxidation of methylamine.  Electrons are passed from methylamine dehydrogenase to amicyanin.
What are the official names of this protein?
Methylamine dehydrogenase light chain, MADH, Methylamine dehydrogenase (amicyanin).
What is the protein family that this protein belongs to?
Belongs to the aromatic amine dehydrogenase light chain family.
What are the subcellular locations of this protein?
Periplasm.
Protein: PYRG_STAAM
Sequence: MTKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITNEIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQIRSDLGRENVMYVHCTLLPYIKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECRDADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKYVSLQDAYLSVVESLKHAGYPFAKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRASEGKISAIKYARENNVPFFGICLGMQLATVEFSRNVLGLEGAHSAELDPATPYPIIDLLPEQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMVISGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: LPXK_CAUSK
Sequence: MKLATPRWWYLREGAPSPITRALLTPLSWIWAAQTARRIARTTPRGADCAVICVGNFTVGGVGKTPIVRELLLTLTKRGRRAHGLARGYGGKLKGPVRVEPSRHTVAEVGDEPLMLAQDFPMWVSRDRVLGARKAAASGAEVVVMDDGHQNPDLRKTLSLVVVDGETREDEWPFGDGRVFPAGPMREPLNVSLGRTDAVIVLLPADLPEADPRLLALFGDTPVLIARLEPAAPPPKGRQVGFAGIGKPWKVERALKAAGCHLVDFAPYPDHGQYDEATLNFLWERAQTYSAGLVTTEKDWVRLPQAWRDRVTPWPVRARFEDEGALGALLESVGL
What is the function of this protein?
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
What are the official names of this protein?
Tetraacyldisaccharide 4'-kinase, Lipid A 4'-kinase.
What is the protein family that this protein belongs to?
Belongs to the LpxK family.
Protein: VAT1_MOUSE
Sequence: MSAEREAAEAATVAAATEAGAETGTGAGEGAPSQPPTVEVASDPQPPPAPEASASASAPPLRCLVLTGFGGYDKVKLQSRPAVPPAPGPGQLTLRVRACGLNFADLMGRQGLYDRLPPLPVTPGMEGAGVVVAVGEGVGDRKAGDRVMVLNRSGMWQEEVTVPSAQTFLMPEAMTFEEAAALLVNYITAYMVLFDFGNLRPGHSVLVHMAAGGVGMAALQLCRTVENVTVFGTASASKHEVLKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYHLLKPMGKVVTYGMANLLTGPKRNLMAMARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVNSVVTRLVALYNQGHIKPRIDSVWPFEKVADAMKQMQEKKNIGKVLLVPGPEKET
What is the function of this protein?
Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms.  Has no effect on cell proliferation (By similarity).  Possesses ATPase activity.  Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity).
What are the official names of this protein?
Synaptic vesicle membrane protein VAT-1 homolog.
What is the protein family that this protein belongs to?
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Mitochondrion outer membrane; Peripheral membrane protein. Note=The majority is localized in the cytoplasm a small amount is associated with mitochondria.
Protein: RNPH_VIBVU
Sequence: MRPNDRAADQVRPIKITRNYTAYAEGSVLVEFGNTKVLCNATVEESVPRWLKGQGKGWVTAEYGMLPRATHSRTRREAANGKQGGRTMEIQRLIARSLRAVVDLEAMGEFMITVDCDVIQADGGTRTASISGASVAMADAFQHLVDSGKLKANPMKGHVAAVSVGILGEDVLCDLEYVEDSAADTDMNVVMTEEGKMIEIQGTAEGEPFSHEQLLALLESAKKGISEIVAAQKAALAN
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: PRMA_HAEIE
Sequence: MAWIQIRLNSTNEKAEQMSDFLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALFDAETDMAEIVRLLKEAKHLDSNTAYKIEQIEDKDWEREWMDNFHPMQFGKRLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTALCLEWLDGLDLKDKSVIDFGCGSGILAIAALKLGAKSAVGIDIDPQAILASRNNAEQNGVADRLQLFLSDEKPSDLKADVVVANILAGPLKELYPIISQLVKPNGDLGLSGILETQAQSVCDAYTQTFALEPVAAREEWCRITGKLKTL
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX3_ONCNE
Sequence: MAHQAHAYHMVDPSPWPLTGAIAALLLTSGTAVWFHFHSLTLLTLGNVLLLLTMYQWWRDIIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHASLAPTPELGGCWPPTGITTLDPFEVPLLNTAVLLASGVTVTWAHHSIMEGERKQTIQALTLTILLGFYFTFLQGMEYYEAPFTIADGVYGSTFFVATGFHGLHVIIGSTFLAVCLLRQVQYHFTSEHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 3, Cytochrome c oxidase polypeptide III.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 3 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: IHFB_AZOSB
Sequence: MTKSELIAQLAARFPQLVAKDADYAVKMILDAMSDALARGDRIEIRGFGSFALNYRPPRVGRNPKSGEKVHVPEKYVPHFKAGKELRERVDIVE
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: NELL1_HUMAN
Sequence: MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLPPGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDLQELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQNN
What is the function of this protein?
Plays a role in the control of cell growth and differentiation.  Promotes osteoblast cell differentiation and terminal mineralization.
What are the official names of this protein?
Protein kinase C-binding protein NELL1, NEL-like protein 1, Nel-related protein 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus envelope. Secreted. Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.
Protein: TAL1_CYBJA
Sequence: HGIHCBTLL
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase-1, Transaldolase I.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.