PharMolix/UniProtQA huggingface dataset:
Protein: JCAD_MOUSE
Sequence: MYSVEDLLISHGYKPARDAAAPCEDKSERCRSTRTGPRAGQGLLNGYKDGATAHTHSRTSLGTGHVSNSENRISRPRGHREHQSTSRTPEARFLNQPSLAWSSQPQSGRDDIYWSRGRQEGSGSLCPRDWKELESRGMAQAYSLPVHVRENLWEVAGRTEHVMKNAIWEEELRMQDMSLESWKKPRELGRQASDGDGRKRPQEKFEGLYPFVHGEHTSQNRKKSQSLPRALSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSFPSPSEPMRNLEKASSSGPFPRPKFGKPLKTPCYSSHSQPRGEGGFQDHQHRDPRGSYPTRSKDPSHELGMLDPGLEPPVYVPPPSYRSPPQHIPNPYLEDPVPRHVSSNQSQQQVPEKPETSCPLPSGSLAARDLYDAMPGSPPQGLPPQPYPIATHGGSIQYIPFDDPRIRHIKLAQPPEFYEEAKLDDTSYNPGLLTTQEPAIGKRQYDDAPSVPRGPTPSPVNEQSSAFVHSSPRWLQGQLPLGIGPGGFHGQTEHHVMGGLTTNVTDIKAEGHASSPQPQSEGTCKTYTKLRKFETGVQSKKSSKKKSNATIFCLVSIPVKSESLVLATDTNNNDFKLVADKTRGLCQGSALQEQSLLSMSSTDLELQALMGSMAWRRTSPRQGLRESEDGQIDDPRILHLIKPKELQASSPWPGHQYRDQQTQTSFHEDSKSSQLLPATKPGEASNVAPTPTCPDTTASEVCLHTALAFSDQNQKPSVPHLQGQTSLSPSRNSAFSRTSSAINQASMSKGTSDQLPGANPVPKPEVVKGESTTGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESHGGSGSEDSEAEQPEDCADSRTKSWALQGTRTAQQPAGLALENVASPDRRLNDSQSWNEEPKPGHSSVHPQSLGPSQEEGSRGVPVQWADGSLTAEQKSQEDLNGMCERDFSPRPVSRIAPIDTKAAPLYCLSEPRGSQELTKFGDAVGSVQLGRETPTQVGNGGDTEVLPCVLLPLADKYRGHSTPDFRSLELTLGQEQNAYKLECLDLENTVEVLPSESLQERAERILGIEVAVESLLPSARRTEQSQLPEPDASACNPSSSREDSSHSLALPVGPKVATDAFYGRRKCGWTESPLFVGERAPQASICSDVDGFPTSQATSPEPGKKDEEAKAPFKSTLFHFMEKSTNVVGPEKRLRNPSKVVENLQEKLVSPPKKADSVHLIRMREVNSLSQMRCLSSKSADSVEEPDPLKVIKSSAWLSEGLTSLGGKDEAWQAGHLPSVSQNENGHPEVPRDKMSDQDLWCADSYDPSRVERV
What are the official names of this protein?
Junctional cadherin 5-associated protein, Junctional protein associated with coronary artery disease, JCAD.
What are the subcellular locations of this protein?
Cell junction, adherens junction. Note=Colocalizes with CDH5/VE-Cadherin in endothelial cells but not in epithelial cells.
Protein: PTAS_RICPR
Sequence: MKKQHIINETFLDEILAQKLGTTYIPPTEIKDSDFDKAAKHFINLLLRADGLKPIKTAVVHPIDKESLLGAVRAAQFNVIKPILIGPQHKIESVAKVNDVDLENYQVINAEHSHEAAKKAVELAKKREVAAIMKGALHTDELMSAVVYKENGLRTERRISHAFLMAVATFPKPFIITDAAINIRPTLEDKRDIVQNAIDLMHIIKEDKQVRVAVLSAVETVTSAIPTTLDAAALSKMADRGQITNAVVDGPLAFDNAISLFAAEAKGISSPVSGNADILVVPDLESGNMLAKQLKYLGQAVMAGIVLGARVPIILTSRADPIDMRVISCVLASFIYNQTKAKLHNSSKSII
What are the official names of this protein?
Phosphate acetyltransferase, Phosphotransacetylase.
What is the protein family that this protein belongs to?
Belongs to the phosphate acetyltransferase and butyryltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HRCA_MYCSS
Sequence: MGSADDRRFEVLRAIVADFVATKEPIGSKTLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLDDVKPLSSAERRAILKFLETGVDLDDVLRRAVRLLAQLTRQVAIVQYPTLSTSSVRHLEVVALTPARLLLVVITDTGRVDQRIVELGDAIDEHELATLRDLLGQALEGKRLSAASVAVSDLATHLSGSPGMSHRLADAVGRSATVLVETLVEHTEERLLLGGTANLTRNTADFGGSLRSVLEALEEQVVVLRLLAAQQEAGKVTVRIGHETEAEQMAGTSVVTTAYGSSGKVYGGMGVVGPTRMDYPGTIANVAAVALYIGEVLGTR
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: FADB_COLP3
Sequence: MIYQGKSLSAQLLEDGIVEFKFDAQGSVNKFDQATFEEYIAVVAAINNCSEAKGVIVTSGKSTFIVGADITEFLVSFSQPEDALASWAKKASDVFDSFEDIQLPTIAAINGIALGGGCEMTLACDYRVAATTASIGLPEVKLGLMPGFGGTVRLPRLIGFDNAATWMSTGKAFKPAAALAQGAIDAVVEPENLQAAAISMLKLAIDGKLDWRAKRQPKLEALKLSPTELIMSSTTCKGMIAAKAGKHYPAPMVMINTLIASANLDRTGAMAAENTGFAKLAKTDAATAQIGLFMADQVIKGKAKKASKLATKAVNKAAVLGAGIMGGGIAYQSAYKGTPIIMKDINDQALDLGLTTATGILTKQVERGRMNAKKMAGVLNNITPSLSYDSVKDVDIVVEAVVENPKVKGMVLAEVEGVIGEDAILTSNTSTISIDLLAQSVKRPQNFCGMHFFNPVNKMPLVEVIRGKDTSDETVAAVVAYAAKMGKSPIVVNDCPGFYVNRVLFPYFAGFSQLVLEGADFTAIDKVMEKQFGWPMGPAYLLDVVGVDTADHCTGVMSSGFPTRMKKIDNDPVSTLYANERLGQKNGKGFYDHIKDKRGRPMKVPAPVAYELLGQHCADKKDFSSEEIIARMMIPMVNEVVRCLEEGVVDTAAEADMGLIYGVGFPPFRGGAIRYLETLGLDNFIAMADKYTDLGEIYHVTDGLREMAKSGKSYFTTDVKLA
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: Y2991_ALBFT
Sequence: MHMPPHLPASPPLSWPQRLEALLKDLTNFPWKSTARTLRERYSEDRLGLTASSLTFTTTMALVPLVTVALAIFTAFPMFAKLQSVLQKWLVTSLIPDNIARQVLGYLTQFAGQASKLGGAGIALLLVTAVALILTIDHTLNGIWRVRTRRSLGQRVLVYWAALTLGPLVLGVSLSITSYAISASKGVVGVMPGGVQFLLDVLQFFMVAWGMAAMYHFVPNTWVKWSHAWAGGMFVSAGLELAKKLLALYLGKVPTYSVLYGAFATVPILLIWIYVAWIIVLLGAVIAAYLPSLTSGIQHRGRSHGLQFQLALETLQQLERVRSDAVKGLTMQQLAQLLRVDALQLEPVLETLSELDWIGLLNEEFKGEAARYVMLANPDATALAPLLDTLLLRREESTQNLWEKGRWPLLNVRDVL
What are the official names of this protein?
UPF0761 membrane protein Rfer_2991.
What is the protein family that this protein belongs to?
Belongs to the UPF0761 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PUR5_METNO
Sequence: MTGERGLTYAEAGVDIDAGNAMVEAIKPLVRSTRRPGADAEIGGFGGLFDLKAAGFKDPILVAANDGVGTKVKIAIETGRHDTIGIDLVAMCVNDIVVQGAEPLFFLDYYATGKLVPGVGADIVRGIAEGCRQAGCALIGGETAEMPGLYDGSDYDLAGFSVGAAERGALLPRPGIAPGDLVLGLPSSGVHSNGFSLVRRIVAASGLGWDAPAPFAPGRSLGEALLTPTRIYVRPLLAALKATGAGAIKALAHITGGGFPDNLPRVLPEGVGIALDLDEIAVPPVFGWLARTGKVAEAEMLRTFNCGIGMVVVVAADRIASVEAALREAGEAPVRLGRITPRGEAPVTFSGSLAL
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMM2_SHEB9
Sequence: MSRKYFGTDGVRGKVGDFPITPDFAMKLGWAAGTVLASTGTKEVLIGKDTRISGYMLESAMEAGFSAAGVNVALIGPMPTPAVAYLASTFRADAGVVISASHNPFYDNGIKFFSNSGTKLNDAQELEIEALLEKALNQNAMQCVASEKLGKVRRIDDAAGRYIEFCKGTFPNHLSLAGLKIVVDSAHGAAYHIAPNVYRELGAEVISINDKPNGVNINDHCGATHLDSLQTAVMVHEADLGIALDGDADRVMFVDHNGHVVDGDEILFILAQAAHSKGEMTGGVVGTLMSNLGLELALKQMDIPFVRAKVGDRYVVEQLKHTGWQLGGEGSGHILSLQHASTGDGIVASLQVLKAVLESQKSLSEIKAGMTKLPQVLINVRLATADADSILATTSVQQAVIKAEEFLGDQGRVLLRKSGTEPLIRVMVESTDNVMTQTQAEYIADAVRAA
What is the function of this protein?
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
What are the official names of this protein?
Phosphoglucosamine mutase 2.
What is the protein family that this protein belongs to?
Belongs to the phosphohexose mutase family.
Protein: MUTL_PECCP
Sequence: MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIERGGAKLIRIRDNGSGIGKDELTLALARHATSKIATLDDLEAIVSMGFRGEALASISSVSRLTLTSRTAEQSEAWQAYAEGRDMAVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFTHIDEVVRRIALARFDVAITLHHNGKLIRQYRAAPDKSQYERRLGNICGATFLQHALAVSWQHGDLTIHGWVADPVGAKQLPDMQYCYVNQRMMRDRLINHAIRQAYQDQLSDDQQPAYVLYLEIDPHQVDVNVHPAKHEVRFHQARLVHDFIYQAVMSVLQQASAPGLGMTSPETGKPVQWQQENRPAAGENHFAQPPRTDNSPSYGGKTPRAGHSGQAKESAYSGYQPENPYQKKQGDLYKALLQPADGAAGASNPSGEHISVPANRVMPPEVVVLSTVSHDSPPNRTAPDATTSSSKPRAPIESPLESQSNGFGRVLTVYPPCYALLEYHKGLAMLSLSVAERHLKAVQLTPSEEGLRAQPLLIPQRLTLSKSELSVLSAHHALLARFGIDVLVESQRATLRAVPLPLRQQNLQNLISELIGYLANYQTVETQQVEPGELASWMATRLQSEQESWSHSQAIQLLADVERLCPQLAKAPPSELLYMMDIHDAIKALKHE
What is the function of this protein?
This protein is involved in the repair of mismatches in DNA.  It is required for dam-dependent methyl-directed DNA mismatch repair.  May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
What are the official names of this protein?
DNA mismatch repair protein MutL.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
Protein: GUAA_DESVM
Sequence: MEAQTKVIIIDYGSQVTQLIARRVREAGVYSEIHPCIVTADQVRAMKPAAVILSGGPASVGEADAPTLEKGLLELGVPVLAICYGMQLLGHNLGGQLATSETREYGPADLTLLGDCPLWDGIDKSATTRVWMSHGDKVKTPPPGFAVVGRTATLDVAAMADDARRIYAVQFHPEVHHTEEGTRIINNFLFHVAKLKADWTMSSFVERAIKEMAETVGDRHVVCALSGGIDSTVVAVLLHKAIGKRLHCIFVDNGVLRLNEGQEVVDYLREHFDLNLKYVQAQRRFLDKLEGVEDPEQKRKIIGYTFIEVFDEEAKALGHVDFLAQGTLYPDVIESVSHKGPSAVIKSHHNVGGLPEKMNLKLIEPLRELFKDEVRKVAGELGLPDFIIWRHPFPGPGLAIRVIGEITEERLDILRKADKIVQAELMSSGWYRKVWQGFAVLLPLKTVGVMGDGRTYEHVIALRIVDSVDAMTADWARLPSELLERISSRIINEVKGVNRVVYDISSKPPSTIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: HIS4_TOLAT
Sequence: MIIPAIDLIDGKVVRLYQGDYGQKTEYSADPQGRFDDYVAQGATQLHLVDLDGAKDSTKRQLTVIRKLLANTKAPVQIGGGVRTEQDVKDLLDAGANRVVIGSTAVKDPVTVAGWVEKYGADKIVLALDVNIDAEGNRKIAVAGWQEDSGVTIEALLAHYLPVGLKHVLCTDISRDGTLQGSNVALYRDLAAQFPQINWQASGGIGGIADIEALKGSGVGGVILGRSLLEGKFTVKEAIACWQDA
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UBIE_AZOVD
Sequence: MNDPRKTESTTHFGYQSVPESQKARKVAEVFHSVAAKYDLMNDVLSGGLHRLWKRFTIELSGVRRGNRVLDIAGGTGDLTLQFSRLVGESGEVLLADINDSMLKVGRDRLLDRGVAGNVRFVQADAEKLPFPDNHFDVITIAFGLRNVTRKEDALRSMLRVLKPGGRLLVLEFSKPSNALLGKVYDAYSFAFMPLAGKLITNDADSYRYLAESIRMHPDQETLKSMMAGAGFERVTYHNMTGGIVALHRGLKP
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: MNME_LACJO
Sequence: MAQVLTQFDTIAAISTPIGEGGISIVRLSGEDAVAIANKLFKGADLTQVPSHTIHYGHIVDPKTKDVVDETMVSVLRAPKTFTREDMVEINCHGGMIVTNDILQLLLANGARMADPGEFTKRAFMNGRIDLTQAESVMDIVRAKTDKSRQVAMTQLAGGLLDKIRTMRQELLDTMAHEEVNIDYPEYDMDDLTSQEMKKKAEEVSKQIDQLLKTAQEGKIIRNGLATAIVGRPNVGKSSLLNYLTQDDKAIVTDIAGTTRDTLEEYVSVKGVPLKLIDTAGIHHTEDKVEKIGVERSKKAIAEADLVLLLLDASQDLTDEDKNLLNLTANKKRIIILNKQDLGTKISQEMIREITDNPIIVTSILKQENMAALENAIEQLFFSGIENSQNQILVTNQRQAGLLAKAKQSLEDVVNGIDDAMPLDLVQIDLKNAWDTLGEITGESAPDELITQLFSQFCLGK
What is the function of this protein?
Exhibits a very high intrinsic GTPase hydrolysis rate.  Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA modification GTPase MnmE.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NLR_MEGGA
Sequence: MKMCDMFQTADWKTEKHVPAIECDDAVAADAFFPVTVSLGKEIAHPNTTEHHIRWIRCYFKPEGDKFSYEVGSFEFTAHGECAKGPNEGPVYTNHTVTFQLKIKTPGVLVASSFCNIHGLWESSKAVALK
What is the function of this protein?
Non-heme iron protein.
What are the official names of this protein?
Neelaredoxin, Superoxide dismutase.
What is the protein family that this protein belongs to?
Belongs to the desulfoferrodoxin family.
Protein: CMOA_WOLSU
Sequence: MRDELFTEELKKQFEFDERVAGVFDDMLSRSIPYYALALELSADFALANLPKEGGWVYDLGCSTGSLLLEIERRAGAKNPRLIGIDNSEAMLSRARAKALGYGSRVDFIQGDILDFEYQKSEVILCHYTLQFIRPIHRAYLVQKLYDSLKPEGILIFSEKVVSEDRVLDHQMIERYYAYKREQGYSEVEIVKKREALENVLIPYTAKENEKMLLEAGFAHVETLFRWVNFATFIAKKGEA
What is the function of this protein?
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
What are the official names of this protein?
Carboxy-S-adenosyl-L-methionine synthase, Cx-SAM synthase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
Protein: Y1399_STACT
Sequence: MEFMEIFKKWAPEYDATVNGENEEYRDVFINYSEMLNELASTAEGRVLEIGAGTGNLTLMLKDKGREVSAIDPSDDMRAIANETKNLDVQYGHFFDIPFDQPFDYIVTSFAFHHVKPEEKSDAIKTMMHSLTDDGKLLILDTMFESEKYKQDLIKYYNNQEFYNLTEDLQTEYYTYIENLKDIVNDLGLNLDMVQKNKFAWLATISK
What is the function of this protein?
Could be a S-adenosyl-L-methionine-dependent methyltransferase.
What are the official names of this protein?
Uncharacterized methyltransferase Sca_1399.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. YrrT family.
Protein: Y2621_CALS4
Sequence: MGEDGKLYIVREEILSDSIKKTIKVKELLESGKAKTINEAVKQVGISRSAFYKYRDYVFPFSKFSKGKIITFSMVLEHMPGVLSSILDVVAKERGNVVTINQSIPSMGVASVTISIDTQYMEISIEDFIEELSKQPGVRKIEVLGE
What are the official names of this protein?
UPF0735 ACT domain-containing protein TTE2621.
What is the protein family that this protein belongs to?
Belongs to the UPF0735 family.
Protein: TAF12_DROME
Sequence: MSDLFTTFDSNGVAEHHLHHNHNSTSSASGLLHDPPMASPSQHSPMTNNSNSSSQNGGPVSGLGTGTGPISGGSKSSNHTSSAAGSENTPMLTKPRLTELVREVDTTTQLDEDVEELLLQIIDDFVEDTVKSTSAFAKHRKSNKIEVRDVQLHFERKYNMWIPGFGTDELRPYKRAAVTEAHKQRLALIRKTIKKY
What is the function of this protein?
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
What are the official names of this protein?
Transcription initiation factor TFIID subunit 12, TAFII30 alpha, Transcription initiation factor TFIID 28-alpha kDa/22 kDa subunits, p28-alpha/p22.
What is the protein family that this protein belongs to?
Belongs to the TAF12 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HUNB_SCACA
Sequence: WYSSMFAANIKQEPMSHHHHHSHHHGHHHMLQHSNSNRNASSPRQSPLPSPNPPSSSNLHLEQYLKQQHQQHQQQQQQPMDTLCAAAMTPSPSNNDQNSPLTPPGLPNPMQIIMPANMRPATQPTPTIATPTTTSSAIVALQTNDKLQALTPPMDVTPPKSPAKSQQSCAEPEKDHDLISNSSEDMKYMA
What is the function of this protein?
Gap class segmentation protein that controls development of head structures.
What are the official names of this protein?
Protein hunchback.
What is the protein family that this protein belongs to?
Belongs to the hunchback C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: SECF_PSEAE
Sequence: MNIKIGTINFMGIRNVAFAVTLILTVIALGSWFTKGINFGLDFTGGTLIELTYEQPADLGKVRGQLVGAGYEDAVVQSFGDARDVLVRMPSEDPELGKKVATALQQADAGNPANLKRVEYVGPQVGEELRDQGGLGMLLALGGILLYVGFRFQWKFALGAILSLVHDAIIVMGVLSFFQVTFDLTVLAAVLAVVGYSLNDTIVIFDRVRENFRVLRKADLVENLNISTSQTLLRTIATSVSTLLAIAALLFFGGDNLFGFSIALFVGVMAGTYSSIYIANVVLIWLNLTSEDLIPPQAKDTVDDRP
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
What are the official names of this protein?
Protein translocase subunit SecF.
What is the protein family that this protein belongs to?
Belongs to the SecD/SecF family. SecF subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SKAP_RAT
Sequence: MATHKAEAQETDFRTTGPPTDLEQCPFPPSSRKFPFESVAADSTEGWAVAAEHHLKRSGEDGGWEQPASGVEPSRPTTMASSKTVCDAQPHSMPSCGLSADTQTRATSKLPVKSKDAEMLRHLHTGGLEPDVTKVTKPRRENGQGKAAETASRRNIRSSYKPLSKQKPEEDLKDKNELLEAVNKQLHQKLTETQGELKDLTQKVELLEKFQDNCLAILESKGLNSGQETQESKQEPSTDPTDSMLLLETLKDELKLFNETAKKQMEELQALKVKLKLKEKERIQFLEQQTLGKDEASDFTIILEEMEQLLEM
What is the function of this protein?
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase.  Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture.  The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.  Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division.
What are the official names of this protein?
Small kinetochore-associated protein, SKAP, Kinetochore-localized astrin-binding protein, Kinastrin, Kinetochore-localized astrin/SPAG5-binding protein, TRAF4-associated factor 1.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore- microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends.
Protein: MALK_YERPN
Sequence: MANVTLSSVYKAFGEAVISRDINLEIDDGEFVVFVGPSGCGKSTLLRMIAGLEDITSGELLIGGKRMNEVPPSERGIGMVFQSYALYPHLSVAENMSFGLKLAGVKKAEIYQRVNQVAEVLQLAHLLDRRPKALSGGQRQRVAIGRTLVSEPDVFLLDEPLSNLDAALRVQMRIEISRLHKRLERTMIYVTHDQVEAMTLADKIVVLDAGNIAQVGKPLELYHYPANRFVAGFIGSPKMNFLPVKVTAAEPRQVQIELPNHQRVWLPVEGDQVQVGANMSLGIRPEHLLPSSASEVTLEGEIQVVEQLGNETQIHIQIPAIRQNLVYRQNDVVLVEEGATFSIGLPPHRCHLFREDGTACKRLYQELGV
What is the function of this protein?
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Maltose/maltodextrin import ATP-binding protein MalK.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: YIHI_ECOUT
Sequence: MKPSSSNSRSKGHAKARRKTREELDQEARDRKRQKKRRGHAPGSRAAGGNTTSGSKGQNAPKDPRIGSKTPIPLGVAEKVTKQHKPKSEKPMLSPQAELELLETDERLDALLERLEAGETLSAEEQSWVDVKLDRIDELMQKLGLSYDDDEEEEEDEKQEDMMRLLRGN
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: ATPB_STRPF
Sequence: MSSGKIAQVVGPVVDVMFASGDKLPEINNALIVYKDSDKKQKIVLEVALELGDGMVRTIAMESTDGLTRGLEVLDTGRAISVPVGKETLGRVFNVLGETIDLEEPFAEDVDRQPIHKKAPSFDELSTSSEILETGIKVIDLLAPYLKGGKVGLFGGAGVGKTVLIQELIHNIAQEHGGISVFTGVGERTREGNDLYWEMKESGVIEKTAMVFGQMNEPPGARMRVALTGLTIAEYFRDVEGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTQKGSVTSIQAIYVPADDYTDPAPATAFAHLDSTTNLERKLTQMGIYPAVDPLASSSRALSPEIVGEEHYAVATEVQRVLQRYRELQDIIAILGMDELSDEEKTLVGRARRIQFFLSQNFNVAEQFTGLPGSYVPVAETVRGFKEILEGKYDHLPEDAFRSVGPIEDVIKKAEKMGF
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PEX5_YEAST
Sequence: MDVGSCSVGNNPLAQLHKHTQQNKSLQFNQKNNGRLNESPLQGTNKPGISEAFISNVNAISQENMANMQRFINGEPLIDDKRRMEIGPSSGRLPPFSNVHSLQTSANPTQIKGVNDISHWSQEFQGSNSIQNRNADTGNSEKAWQRGSTTASSRFQYPNTMMNNYAYASMNSLSGSRLQSPAFMNQQQSGRSKEGVNEQEQQPWTDQFEKLEKEVSENLDINDEIEKEENVSEVEQNKPETVEKEEGVYGDQYQSDFQEVWDSIHKDAEEVLPSELVNDDLNLGEDYLKYLGGRVNGNIEYAFQSNNEYFNNPNAYKIGCLLMENGAKLSEAALAFEAAVKEKPDHVDAWLRLGLVQTQNEKELNGISALEECLKLDPKNLEAMKTLAISYINEGYDMSAFTMLDKWAETKYPEIWSRIKQQDDKFQKEKGFTHIDMNAHITKQFLQLANNLSTIDPEIQLCLGLLFYTKDDFDKTIDCFESALRVNPNDELMWNRLGASLANSNRSEEAIQAYHRALQLKPSFVRARYNLAVSSMNIGCFKEAAGYLLSVLSMHEVNTNNKKGDVGSLLNTYNDTVIETLKRVFIAMNRDDLLQEVKPGMDLKRFKGEFSF
What is the function of this protein?
Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:8265627, PubMed:7980572, PubMed:14562106, PubMed:35768507).  Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:9094717).  PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:35768507).
What are the official names of this protein?
Peroxisomal targeting signal receptor, PTS1 receptor, PTS1R, Peroxin-5.
What is the protein family that this protein belongs to?
Belongs to the peroxisomal targeting signal receptor family.
What are the subcellular locations of this protein?
Cytoplasm. Peroxisome membrane; Peripheral membrane protein. Note=Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).
Protein: MURE_LIGS1
Sequence: MALEITPALSLLDEHHLLKEVVNEQKLTFENVTYDSRKVSDNTLFFCKGNFKPSYLTSALEKGATAYVSEQKYAEGMDATGIIVTNVQKAMALLGAAFYGFPQNELFIIAYTGTKGKTTSAYFAEHILAKATDKKVALFSTIDRVLGNEPDQRFKSDLTTPESLDLFHDMRAAVNNGMTHLVMEVSSQAYKKNRVYGLTFDVGVFLNISPDHIGRNEHPTFDDYLHCKEQLLVNSKRCVINGETAYLRDVYYTAKATTEPEDIYVFARKGAQISDNIPVDIEYQNDFEDLHKSVIEVKGLSDKAQTLHVDGKYELSVPGDYNEGNATSAIIATLLAGAKGEDARKTLDRVHIPGRMEIIKTKNNGTIYVDYAHNYASLKALFAFLKQQTHAGRVIAVLGSPGDKGISRRPGFGKAVSEEVDHVILTTDDPGFEDPMKIAQEIDSYINHDNVKVEFELDREIAIEKAIKMSTNNDIVVLAGKGEDPYQKIKGVDVPYPSDVNVAKKIVEEL
What is the function of this protein?
Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramyl-tripeptide synthetase, UDP-MurNAc-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KGUA_BACSU
Sequence: MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSPREGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLEIEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMMDAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE
What is the function of this protein?
Essential for recycling GMP and indirectly, cGMP.
What are the official names of this protein?
Guanylate kinase, GMP kinase.
What is the protein family that this protein belongs to?
Belongs to the guanylate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLIR_BUCAI
Sequence: MLTFNSLQLITLISNFFWPMIRVLSFFSVAPIFKEKLINRKSKILLSGMISWLVWPFLPEVHTVLFSYFGFLLILQQILIGIVLGFTAQLLFATINLSGEIIGLQMGLSFATFFNNNSQIGTSIISRFLNILALFVFITLNMHLYLISIVIDSFYSMPIDGYFLNVNIFFILLKFSSSIFLNGLLLVLPIMIILLSISFVMSLLNRLSPQISIFSIGFPLNLILGMLMLYFLIPVMLPFLKKILDDLIFFMNNNLLHI
What is the function of this protein?
Role in flagellar biosynthesis.
What are the official names of this protein?
Flagellar biosynthetic protein FliR.
What is the protein family that this protein belongs to?
Belongs to the FliR/MopE/SpaR family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Bacterial flagellum basal body.
Protein: CIAO1_SCHJA
Sequence: MLNVREVQKLKASNKRLWSLSWNHKGSVLISSGEDRVIKLWAKCNDQLWGSSFSLPEAHKKSIRCVTWSPCGTYIASASFDGTVTIWKISEAHSAPEMEALVSLEGHTSEVKCVAWCPSGHLIATCGRDKSVWLWEFDDEEDVQCVSVLQPHSQDVKSVAWHPHGEVLVSTSYDNKINVYREELDDWTVFAQLSGHDSTVWKAEFSPSGDILASCSDDLCVKLWSWEGVCGKSSSWMCIATLSGYHTRTIFDLNWSPDSQLLASCGSDNRLCIYKMPANGLTHIGGKPCFEEPPVLWGHVPNAHSEDVNCVRWKPGNITDISHSESISNCHLFLTTASDDGYIKFWSIEYEL
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for the maturation of extramitochondrial Fe/S proteins.
What are the official names of this protein?
Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CIA1 family.