PharMolix/UniProtQA huggingface dataset:
Protein: RB3GP_HUMAN
Sequence: MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKGIFTSGTWEEKSDEISFADFKFSVTHHYLVQESTDKEGKDELLEDVVPQSMQDLLGMNNDFPPRAHCLVRWYGLREFVVIAPAAHSDAVLSESKCNLLLSSVSIALGNTGCQVPLFVQIHHKWRRMYVGECQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRFTYVLQDWQQYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYSDLDPIQAPHWSVRVRKAENPQCLLGDFVTEFFKICRRKESTDEILGRSAFEEEGKETADITHALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLFPDAVSEKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHLWQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASDVTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAKLGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVVLKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPADLARHLLPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVEALIARARSLKAKFGTEKCEQEEEKEDLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVNAQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKALPQRMYSVLTKEDFRLAGAFSSDTSFF
What is the function of this protein?
Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18 (PubMed:9030515, PubMed:10859313, PubMed:24891604).  As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP (PubMed:10859313).  Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones (PubMed:15696165).  The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP (PubMed:24891604).  Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (PubMed:24891604).  Required for normal eye and brain development (PubMed:15696165, PubMed:23420520).  May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (PubMed:9030515, PubMed:9852129).
What are the official names of this protein?
Rab3 GTPase-activating protein catalytic subunit, RAB3 GTPase-activating protein 130 kDa subunit, Rab3-GAP p130, Rab3-GAP.
What is the protein family that this protein belongs to?
Belongs to the Rab3-GAP catalytic subunit family.
Protein: FAKD4_HUMAN
Sequence: MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKPFSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPSLTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK
What is the function of this protein?
Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6.  May play a role in cell cycle progression (PubMed:9383053).
What are the official names of this protein?
FAST kinase domain-containing protein 4, Cell cycle progression restoration protein 2, Cell cycle progression protein 2, Protein TBRG4, Transforming growth factor beta regulator 4.
What is the protein family that this protein belongs to?
Belongs to the FAST kinase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: SYM_BURP1
Sequence: MSASDLTSVQAGAPQGRRQILVTSALPYANGQIHIGHLVEYIQTDIWVRTMRMHGHEIYYIGADDTHGTPVMLRAEQEGVSPKQLIERVWREHKRDFDSFGVSFDNFYTTDSDENRVLSETIYLALKEAGFIAEREIEQAYDPVRQMFLPDRFIKGECPKCHAKDQYGDSCEVCGTTYQPTDLIHPYSVVSGAAPVRKTSTHYFFRLSDPRCEAFLREWVSGLAQPEATNKMREWLGEAGEAKLADWDISRDAPYFGFEIPGAPGKYFYVWLDAPVGYYASFKNLCERRGLDFDAWIRKDSTTEQYHFIGKDILYFHTLFWPAMLEFSGHRTPTNVFAHGFLTVDGAKMSKSRGTFITAQSYIDTGLNPEWLRYYFAAKLNATMEDIDLNLEDFQARVNSDLVGKYVNIASRAAGFLLKRFDGRVQASAMNHPLLATLRGAIPQIAAHYEAREYGRALRQTMELADAVNGYVDSAKPWELAKDPANAVALHETCSVSLEAFRLLSLALKPVLPRVAQGVEAFLGIAPLTWADAGTPLSPEQPVRAYQHLMTRVDPKQIDALLAANRGSLQGTAAAAEAGAANGNGAGSKNGKGAKAAAQPAASAANADDGASPIISIDDFAKIDLRIAKIVACQAVEGSDKLLQLTLDVGEERTRNVFSGIKSAYRPEQLVGKLTVMVANLAPRKMKFGLSEGMVLAASAADEKAEPGLYILEPHSGAKPGMRVK
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT2B1_HUMAN
Sequence: MGDMANNSVAYSGVKNSLKEANHDGDFGITLAELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEGEGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGDEKDKKKANLPKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIHNFMTHPEFRIEDSEPHIPLIDDTDAEDDAPTKRNSSPPPSPNKNNNAVDSGIHLTIEMNKSATSSSPGSPLHSLETSL
What is the function of this protein?
Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis (PubMed:35358416).  Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction.  Positively regulates bone mineralization through absorption of calcium from the intestine.  Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity).  Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511).  May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.
What are the official names of this protein?
Plasma membrane calcium-transporting ATPase 1, Plasma membrane calcium ATPase isoform 1, PMCA1, Plasma membrane calcium pump isoform 1.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Synapse. Presynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Note=Colocalizes with SV2A in photoreceptor synaptic terminals. Colocalizes with NPTN to the immunological synapse. Colocalizes with EPB41 to the basolateral membrane in enterocyte. Preferentially sorted to recycling synaptic vesicles.
Protein: COBD_LEPIC
Sequence: MPWGIAISILVDLILGDPKDLPHPVRAIGKLARALEKFFRNNCSSEEIAGILTSCLVYLISFIIPFLSVQFANQLHWILGELLSIMIIYTTIAIRDMIDHSKEVYDALVQTNLPLARKKVSKIVARDTENLSESEIIRACVESTAENLVDGITTPLFYAVFGGPAWAMLYRSINTLDSLFGYKNKKYLRFGSFPARIDDLANYLPARITSYILVLSSLFLGYNFKNSLYILQRDGKKHPSPNSGLTEAAVAGALEIQLGGVNLYSGVQNIKPKLGDPKKEFQIEQILQTNKLILLSSILTFIFYILIYSGAAYFL
What is the function of this protein?
Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
What are the official names of this protein?
Cobalamin biosynthesis protein CobD.
What is the protein family that this protein belongs to?
Belongs to the CobD/CbiB family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OBG_MYCGI
Sequence: MPRFIDRVVVHARAGNGGNGCASVHREKFKPLGGPDGGNGGRGGSVVFVVDPQVHTLLDFHFHPHVVAPSGKQGAGSNRDGAAGADLEVKVPDGTVVLDERGQILADLIGAGTRFEAAAGGRGGLGNAALASRARKAPGFALLGEQGEVRELTLELKTVADVGLVGFPSAGKSSLVSTISAAKPKIADYPFTTLAPNLGVVSAGEHTFTVADVPGLIPGASEGRGLGLDFLRHIERCAVLVHVVDCATLEPGRDPISDIEALEAEIAAYTPTLQGDSTLGDLAERPRAVVLNKIDVPEARELADFVREDVETRFGWPVFEISTVAREGLRPLIFALWDMVAAYRAAQPAAVPRRPVIRPIPVDETAFSVVPDGQGGFVVKGTRPQRWVAQTNFDNDEAVGYLGDRLARLGVEDELLKLGARPGCAVTIGDMTFDWEPQTPAGVDVHLSGRGTDVRLEQTDRVGADERKAARKARRQSDDGEE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PDXT_RENSM
Sequence: MTIGRTLRAGVLALQGDVREHLAALEACGAEAVPIRRASELADLDGLVLPGGESTAIDRLIRAFELSEPLKAFIASGKPVYGSCSGMILLADRIADPALDRDGAPQRTLGGLDVTVRRNAFGRQRDSFETELKFDSLSDSERPVHAVFIRAPWIEQAGSEVEVLAVVRIEGIDRAVAVRSGNLLATSFHPEVLVQESETSELRVHELLVSMMASRLSQDANQAESRK
What is the function of this protein?
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate.  The resulting ammonia molecule is channeled to the active site of PdxS.
What are the official names of this protein?
Pyridoxal 5'-phosphate synthase subunit PdxT, Pdx2, Pyridoxal 5'-phosphate synthase glutaminase subunit.
What is the protein family that this protein belongs to?
Belongs to the glutaminase PdxT/SNO family.
Protein: FHI2A_HUMAN
Sequence: MFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLLHHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFLENKMKSLASKGVPNVISEDTLKGQDSLSTDTGQSRQPEELSGATGMEQTELEDEPPHQMDHLSTSLDNLSVTSLPEASVVCPNQDYNLVNSLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAINWGLDSYSHKEDASAFPGKRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVFFILGEQREPETLAEISRHPLRHRLIEHCDHISDEISIMTLRMFEHLLQKPNEHILYNLVLRNLEERNYTEYKPLCPEDKDVVENGLIAGAVDLEEDPLFTDISPENTLPNQEWLSSSPPATPDHPKNDGKTEVHKIVNSFLCLVPDDAKSSYHVEGTGYDTYLRDAHRQFRDYCAICLRWEWPGSPKALEKCNLEAAFFEGHFLKVLFDRMGRILDQPYDVNLQVTSVLSRLSLFPHPHIHEYLLDPYVNLAPGCRSLFSVIVRVVGDLMLRIQRIQDFTPKLLLVRKRLLGLEPEGPIIDHITLLEGVIVLEEFCKELAAIAFVKYHASSTP
What is the function of this protein?
Required for proper functioning of the nervous system.
What are the official names of this protein?
FHF complex subunit HOOK interacting protein 2A, FHIP2A.
What is the protein family that this protein belongs to?
Belongs to the FHIP family.
Protein: RBFA_STAAC
Sequence: MSSMRAERVGEQMKKELMDIINNKVKDPRVGFITITDVVLTNDLSQAKVFLTVLGNDKEVENTFKALDKAKGFIKSELGSRMRLRIMPELMYEYDQSIEYGNKIERMIQDLHKQDR
What is the function of this protein?
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit.  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes).  Required for efficient processing of 16S rRNA.  May interact with the 5'-terminal helix region of 16S rRNA.
What are the official names of this protein?
Ribosome-binding factor A.
What is the protein family that this protein belongs to?
Belongs to the RbfA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GRPE_PROM5
Sequence: MIEEQSDNVENKDENVSMDNNISENLPIAEEQTNEDKKLPDDNNEKIDAEDLKNTITNNDARLEQLEKEHETLKSQYVRIAADFDNFRKRQSRDQDDLKIQLVSKALTAILPIVDNFERARQQLKPEGDEAQTLHRSYQGLYKQLVEVLKQQGVAPMRVVGQQFDPNLHEAVLREPSEEQNEDIIIEELQRGYHLEGKVLRHALVKVSMGPGQQISQESEEKDKVDKDIDSEGSISEEN
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE.  It is the nucleotide exchange factor for DnaK and may function as a thermosensor.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
What are the official names of this protein?
Protein GrpE, HSP-70 cofactor.
What is the protein family that this protein belongs to?
Belongs to the GrpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPOZ_STRPZ
Sequence: MMLKPSIDTLLDKVPSKYSLVILQAKRAHELEAGATPTQEFKSVKSTLQALEEIESGNVVIHPDPSAKREAVRAKIEAERLAKEEEERKIKEQIAKEKEEEGEKI
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: TX319_LYCSI
Sequence: MKFVLLFGVFLVTLFSYSSAEMLDDFDQAAEDELLSLIEKEEARAKECTPRFYDCSHDRHSCCRSELFKDVCTCFYPEGGDNEVCTCQQPKHLKYMEKAADKAKKFGGKIKKWFG
What are the official names of this protein?
U3-lycotoxin-Ls1a, Toxin-like structure LSTX-B19.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 19 (CSTX) family. 01 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YHJE_BACSU
Sequence: MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPLIVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLMLWVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGYDLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ
What are the official names of this protein?
Uncharacterized membrane protein YhjE.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GATA_CUPMC
Sequence: MPFSADSVTSLRQIADALAARSVSAEELAREYLARIEAGRALNAFVAVDPELTLAQARAADERRAQGQATPLTGVPIAHKDVFVTRGWKSTAGSKMLANYESPFDATVVERLAAAGMVTLGKTNMDEFAMGSSNENSFFGPVSNPWDTSRVPGGSSGGSAAAVAAGLAPAATGTDTGGSIRQPASFSGITGIKPTYGRVSRYGMIAFASSLDQGGPMAHSAEDCALLLNGMAGFDPKDSTSLTPELGGVTEDFTRLLGQPRAGATASQPLAGLRIGLPREYFGKGLSADVEQALRAALAEYEKLGATLVDVTLPKTELSIPVYYIIAPAEASSNLSRFDGVRYGHRAAQYGDLLDMYKKSRAEGFGPEVKRRIMVGTYVLSHGYYDAYYLQAQKIRRIIADDFQRAFTQCDVIMGPVAPTVAWKLGEKTADPVQMYLADIFTLSTSLAGLPGMSVPCGFGEGNMPVGLQLIGNYFDEAQLLQTAHAFQQATDWHLRRPA
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: TSAD_LISIN
Sequence: MGGLMKKNTLILGIESSCDETAASVVKNGCEIVSSVVASQIESHKRFGGVVPEIASRHHVEQITLVIEEALKQANVTMDDLDGVAVTEGPGLVGALLIGVNAAKTLAFMHNLPLVGVHHIAGHIYANRFETEFQFPLLSLVVSGGHTELVLMKADNEFEIIGETRDDAAGEAYDKVARTLGLAYPGGVQIDKLAKDGEDTFHFPRAMMDDGSFDFSFSGLKSSFINTLHNLRQRGEEPNPNDMAASFQASVVDVLVSKTIRAAKQHGVKQLLLAGGVAANQGLRERLIQEVKLELPDTELIIPPLSLCGDNAAMIAAAGTVSFLQGKRSNYDMNANPGLLLEDI
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC_THEMA
Sequence: MSVNLKGRSLLTLLDFSPEEIRYLLDISKQVKMENRSKLRTERFKGMTLAMIFEKRSTRTRLAFETAFAEEGGHPIFLSPNDIHLGAKESLEDTARVLGRMVDAIMFRGYKQETVEKLAEYSGVPVYNGLTDEFHPTQALADLMTIEENFGRLKGVKVVFMGDTRNNVATSLMIACAKMGMNFVACGPEELKPRSDVFKRCQEIVKETDGSVSFTSNLEEALAGADVVYTDVWASMGEEDKEKERMALLKPYQVNERVMEMTGKSETIFMHCLPAVKGQEVTYEVIEGKQSRVWDEAENRKHTIKAVMIATLL
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RNH_BUCAP
Sequence: MLKLVKMFSDGSCLGNPGSGGYGTILRYKLHEKILTSGFFLTTNNRMELMGVICGLESLKESCIVEITIDSQYVKQGITNWIATWEKKKWKTTKKKLIKNLDLWLRINAVIKNHHITWFWVKAHMGHLENERCDKIARQSAQSPSVKDFFYENNFYQNKNL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBK34_ARATH
Sequence: MSPSSKKFKKQSSSKSVKPPLEDNDPSLPSFTSLPDEIVLDCLQRVPRSYYLNLCRVSKTLRSLVRSPELSRLRTLLPKNSVYVSFSQNIINVPPDTIYRWFTLKKKTMKTAMKTFRYKLVKIPIPFPSHHSMYNSSAVGSEIYFVGGSFEPMSELWILDTRTGMFRQGPSMKVARTDEASVGVINGKIYVIGGCEDKIQVEVYDPKSRSWKTTKDPEEKTQRGLMTRLSAVSLDWKVYTVEVGRIGVYDPREAGVDGF
What are the official names of this protein?
F-box/kelch-repeat protein At2g22050.
Protein: LOLD_PSEPF
Sequence: MSEKAILSCRNLGKSYEEGPESVEVLANLQLELHPGERVAIVGKSGSGKSTLLNLLGGLDTPTKGGVWLDGEELSALSEKKRGLLRNRALGFVYQFHHLLPEFTALENVCMPLLIGKTAIPEARQRATALLERVGLGHRLEHKPAELSGGERQRVAIARALVNNPGLVMLDEPTGNLDSHTAEGIQDLMLELSTSMRTAFLVVTHDMNLARQMDRVLQLQEGCLTPI
What is the function of this protein?
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA.  Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
What are the official names of this protein?
Lipoprotein-releasing system ATP-binding protein LolD.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ATP6_CAPHI
Sequence: MNENLFTSFITPMMLGLPLVTLIILFPSLLFPSSNRLINNRLVSLQQWALQLMSKQMMSIHNTKGQTWTLMLMSLILFIGSTNLLGLLPHSFTPTTQLSMNLGMAIPLWAGAVITGFRNKTKASLAHFYPQGTPTPLIPMLVIIETISLFIQPMALAVRLTANITAGHLLIHLIGGATLALTSISPTTALITFIILILLTILEFELGTREAYVFTLLVSLYLHDNT
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, F-ATPase protein 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: ARGR_CHLPD
Sequence: MNKQLRQLKVREILCQHDVGNQHDLMRLLNSAGIRVAQATLSRDCNEIGVVRSRDSKGYRLVYSEKNPGWIIKGLVGVEVLSVKANETSIIIRTLPGRAHGVGSFLDELKSPMILGTIAGDDTVLVIPGSIKQISELVSYIKDNLSQNA
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MYL9_BOVIN
Sequence: MSSKRAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
What is the function of this protein?
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation.  Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity).  In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).
What are the official names of this protein?
Myosin regulatory light polypeptide 9, Myosin regulatory light chain 2, smooth muscle isoform, Myosin regulatory light chain 9.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts.
Protein: URE1_THEVB
Sequence: MSYRIDRQTYAETYGPTVGDRLRLADTDLIIEIEHDYTHYGDEVKFGGGKVIRDGMGQSPIANAEGAVDVVITNAVILDWWGVVKADVGIKDGKIYKIGKAGNPYTQEGVDIIIGPGTEAIAGEGMILTAGGIDAHIHFICPQQIATAIAAGITTMIGGGTGPATGTNATTCTPGPWNIYRMLQAADAFPVNLGFLGKGNSSQPQGLIEQVQAGVVGLKLHEDWGSTPNAIDTCLSVAEDYDIQVAIHTDTLNESGFVEDTIAAFKNRTIHAYHTEGAGGGHAPDIIKLCGQANVLPSSTNPTRPYTVNTLDEHLDMLMVCHHLDPSIPEDVAFAESRIRRETIAAEDILHDLGAFSIISSDSQAMGRVGESIIRTWQTAHKMKVQRGHLRDPQRPGVDHDNFRARRYVAKYTINPAITHGIAEYVGSVEVGKIADLCLWKPAFFGVKPELVIKGGVIAYAQMGDANASIPTPQPVHMQPMFASYGGCRTTTSVTFMSQAGIANNIPEQLGLQKTVLPVGHIRQLRKADLKLNDYLPHIEVDPETYEVRADGELLTCEPATVLPLAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.