PharMolix/UniProtQA huggingface dataset:
Protein: RLMKL_AERS4
Sequence: MKEFFATCPKGLENLLADELTTLGAEQVRETVAGVHFKGELAIGYKACLWSRFASRIVLVLSEFQMNDDLDLYLGAHTIPWEEHFSGTSTIAVDFTGTNPAIRNTQYGALKIKDAIVDRFTKRGHVRPDVDKKAPDIRIMAHLGKGKANITLDLSGPALHQRFYRQGTGEAPLKENLACAMIARSGWAGEPMMDPMCGSGTLLIEAAFIAADMAPALRRERFGFDRWLQHDSELWQSLMMEAQVRAKRGMQRCEVKLFGCDADPRVLMKARDNAKAAGVAHLITFKQADVTQLENPLPMPAVVEGEVSQEEARQVGMLISNPPYGERLGEFPALLEVHQALGDALRRGFQGWRVSILSASPELLSCLRLRADKQYRLFNGALECQLRNYQIALDSVASQKEVAQDFANRLRKNLKTLEKWASKEGIDCYRLYDADLPEYNAAIDRYQDYLVVQEYAAPKDIPAQKTRQRLLDMVQAAIKVTGMDGEKVILKVRERQEGKQQYQKLAAEQHRMEVQEYGARLWVNLYDYLDTGLFLDHRQTRRMLGQMAKGKRFLNLFAYTGSATVHAGLGGASETTTVDMSHTYLNWAQDNMRLNSLVGRQHKFVQADCLKWLSEADDQYDLIFIDPPTFSNSKRMDESFDVQRDHLLLMQHLKRLLAADGTLVFSNNKRHFKMDLAGLEAAGLKAQNITSKTRPKDFERNQHIHNCWIITHAEAPAEA
What is the function of this protein?
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase K/L.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RlmKL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYFB_XYLFT
Sequence: MKFSENWLRNHAPIQANRDVLVATLTAIGLEVENVAVLGEALDLILVARIVNVVPHPESDLLQICQVDVAQDTLLQIVCGASNVRPGLVVPLALLGAKIGALTIKSTTLRGIESNGMLCSAKELGLDTEASGLMELPEDAPIGTPLADYLALPDASIEIKLTPNRADCFSVRGIAFDVAAACASEVTPFHIDEIPAVSARTLPVELHAGANAPRYCGCVIEGIDPAAPTPVWMAERLRRSGIRPVSLLVDITQYVMLELGQPMHAFDVDTLRGPIGVRLSRNDEALKLLDGRTVVLDNDFLVVTDADQPIALAGLIGGWETRITDTTINVFLEAAHFAPAAIMGRGRKLGLHTDASHRFERGVDPALPPQAIAFATRLILELAGGKPGSLIHVQLPEYLPAPASILLRRTRIARLLGIVIDDAEVERILQALGMQVTTQAEGWRVVAPSRRFDIAIEEDLIEELVRIRGYEHLPTALPVGASHIAMPSETRLDMTSVRRQLIARELQETINYAFIDAELLRRWQLNTGQVMLMNPLSAELAVMRPRLLPGLVAALGRNIARQLERVRLFELGNVFTASDEAGAAPLETRHVAAAVCGDAFALQWGEQVRKVDFYDLKGDLESLAAASGAVLTFHSSAQPWGHPGRSADVWCDDMCIGWIGQLHPALTQTLEINVDVIAFELALEPLVRRALPRAHALSRFPFVRRDLACVVPEHVTWSELAITVRDVIGPLLRDVKLFDRYVGKGIEPGFKSLAIGLILQDDTRTLIDRDVDDIMTKVVMAIQQRHDVRIRS
What are the official names of this protein?
Phenylalanine--tRNA ligase beta subunit, Phenylalanyl-tRNA synthetase beta subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ECP_GORGO
Sequence: MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRVINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCLHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCRYADRPGRRFYVVACDNRDPQDSPRYPVVPVHLDTTI
What is the function of this protein?
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity.  Possesses a wide variety of biological activities.  Exhibits antibacterial activity (By similarity).
What are the official names of this protein?
Eosinophil cationic protein, ECP, Ribonuclease 3, RNase 3.
What is the protein family that this protein belongs to?
Belongs to the pancreatic ribonuclease family.
What are the subcellular locations of this protein?
Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
Protein: YEAL_ECOSM
Sequence: MFDVTLLILLGLAALGFISHNTTVAVSILVLIIVRVTPLSTFFPWIEKQGLSIGIIILTIGVMAPIASGTLPPSTLIHSFLNWKSLVAIAVGVIVSWLGGRGVTLMGSQPQLVAGLLVGTVLGVALFRGVPVGPLIAAGLVSLIVGKQ
What are the official names of this protein?
UPF0756 membrane protein YeaL.
What is the protein family that this protein belongs to?
Belongs to the UPF0756 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: COBS_CARHZ
Sequence: MLTTFLLGLTFFTRIPVPGKLNFSEEKFNRAPIFLPAYGLVTGGILALIIELFGRSFPGFFWAGVIIAGQIYLSGALHIDGLLDSLDAIYSNRDREKRLEILKDSRVGSMAVAFFGAFLILKYGSYASFTPKVQAFTVLISEIILRGTGYLVIYSFPYVGSSLGRGFKDNASTAGLIFTLGQTLIFTLGAAAFFNFSLIKILIILLLAYLFAFVVAARWQQFFGGLTGDNYGGIMELTGLFVPVAVLLINNIGVV
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: OMP7_STAAC
Sequence: MKFKSLITTTLALGVLASTGANFNNNEASAAAKPLDKSSSSLHHGYSKVHVPYAITVNGTSQNILSSLTFNKNQNISYKDLEDRVKSVLKSDRGISDIDLRLSKQAKYTVYFKNGTKKVIDLKAGIYTADLINTSEIKAININVDTKKQVEDKKKDKANYQVPYTITVNGTSQNILSNLTFNKNQNISYKDLEDKVKSVLESNRGITDVDLRLSKQAKYTVNFKNGTKKVIDLKSGIYTANLINSSDIKSININVDTKKHIENKAKRNYQVPYSINLNGTSTNILSNLSFSNKPWTNYKNLTSQIKSVLKHDRGISEQDLKYAKKAYYTVYFKNGGKRILQLNSKNYTANLVHAKDVKRIEITVKTGTKAKADRYVPYTIAVNGTSTPILSDLKFTGDPRVGYKDISKKVKSVLKHDRGIGERELKYAKKATYTVHFKNGTKKVININSNISQLNLLYVQDIKKIDIDVKTGTKAKADSYVPYTIAVNGTSTPILSKLKISNKQLISYKYLNDKVKSVLKSERGISDLDLKFAKQAKYTVYFKNGKKQVVNLKSDIFTPNLFSAKDIKKIDIDVKQYTKSKKNNKSNNVKFPVTINKFENIVSNEFVFYNASKITINDLSIKLKSAMANDQGITKHDIGLAERAVYKVYFKNGSSKYVDLKTEYKDERVFKATDIKKVDIELKF
What is the function of this protein?
Binds various plasma and ECM-proteins.
What are the official names of this protein?
77 kDa membrane protein.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: PURA_RHIE6
Sequence: MTNVVVVGSQWGDEGKGKIVDWLSERADIVVRYQGGHNAGHTLVIDGTSYKLSLLPSGVVRPGKMAVIGNGVVVDPHALIAEIEKLAGQGVTITPDNLRVADNATLILSLHRELDAMREDAASNSGTKIGTTRRGIGPAYEDKVGRRAIRVMDLADLDSLPGKVDRILTHHNALRRGLGVAEVSHQTIMDELTSVAERVLPFRDTVWLFLDKERRRGARILFEGAQGSLLDIDHGTYPFVTSSNTVAGQAAAGSGMGPGSLGYILGITKAYTTRVGEGPFPTELKDEIGEFLGQKGHEFGVVTGRKRRCGWFDAALVRQSVATNGITGIALTKLDVLDGLEELKICVGYMLDGEQIDHLPASQGAQARVEPIYITLEGWKESTVGARSWADLPAQAIKYVRQVEELIGAPVALLSTSPERDDTILVTDPFED
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOK_BLOFL
Sequence: MIPLSHGLGITIILFALGLLGMIVRRNFLFILLGLEIMIHSAALAFVVVGAYLGQEDGQIMYMLVVTLAASESAIALALLLRLHRYCHTLNVDSINEIVE
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUSB_STRZJ
Sequence: MTSPLLESRRQLRKCAFQALMSLEFGTDVETACRFAYTHDREDTAVQLPAFLIDLVSGVQAKKEELDKQITQHLKAGWTIERLTLVERNLLRLGVFEITSFDTPQLVAVNEAIELAKDFSDQKSARFINGLLSQFVTEEQ
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: HEMAT_BACSU
Sequence: MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLGDAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQEMFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLKAIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSRSVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEMVKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSEDTKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISKEQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE
What is the function of this protein?
Heme-containing signal transducer responsible for aerotaxis, the migratory response toward or away from oxygen.
What are the official names of this protein?
Heme-based aerotactic transducer HemAT.
What is the protein family that this protein belongs to?
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
Protein: DCUP_DELAS
Sequence: MSFAPLTNDTFLRACRRQATDYTPLWLMRQAGRYLPEYKATRARAGSFMGLATNVDYATEVTLQPLERFPLDAAILFSDILTVPDAMGLGLSFAEGEGPRFAKVVRDEAAVAELAVPDMDKLRYVFDAVTSIRRALDGRVPLIGFSGSPWTLACYMVEGKGSDDYRLVKSLMYARPDLMHRILAINADSVAAYLNAQIDAGAQAVMVFDSWGGVLADGAFQEFSLAYTKRVLAGLNRTGADGQDVPRIVFTKGGGIWLPDMKDLDCEVLGLDWTANLARARAIVGGEVGGPGKALQGNIDPNVLFAPPERVAEQARAVLDSFGAPHTDRTTTGPTHIFNLGHGISQFTPPEHVAALVETVHSHSRALRQR
What is the function of this protein?
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
What are the official names of this protein?
Uroporphyrinogen decarboxylase, UPD, URO-D.
What is the protein family that this protein belongs to?
Belongs to the uroporphyrinogen decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBX7_CAEEL
Sequence: MYFQILVLMSEGYGRSLFSEKHFPHDRQLLPPFTTTMSLGSFFSFPASSAFFDRKKDDGVIDNPNVELVNRNLWSTFLECGTEMIITKKGRRMFPLVKLKLSGLDKNSNYTIIMEMISVDKLRYKFWNGNWIVAGVGEHHPLPTCFVHPQSPRSGEWWMTDGVDFKMAKLSNNPFNNDGHIVLNSMHRYNPRFHIVRADSSGQPILASLKTFSFKETEFIAVTAYQNDVVTKCKIDNNPFAKGFRNIDTVRKRKMNQIISTPPASEDEEPEVKRTKSEIEAVMFSDPKVPQMSLQLISQWQEALLSTIVQIPITNQKSSSERKSGFGVVDLLGSS
What are the official names of this protein?
Putative T-box protein 7.
What are the subcellular locations of this protein?
Nucleus.
Protein: TPP1_MACFA
Sequence: MGLQACLLGLFALILSGKCSYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNLERLSELVQAVSDPNSPQYGKYLTLENVADLVRPSPLTLHMVQKWLLAAGAQKCHSVITQDFLTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPRPYQLPQALAPHVDFVGGLHRFPPTSSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVTRVVGQQGRGRAGIEASLDVQYLMSAGANISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDEEDSLSSAYIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYVTTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVAKFLSSSPHLPPSGYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGLLSLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTHGCHASCLDEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
What is the function of this protein?
Lysosomal serine protease with tripeptidyl-peptidase I activity.  May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases.  Requires substrates with an unsubstituted N-terminus (By similarity).
What are the official names of this protein?
Tripeptidyl-peptidase 1, TPP-1, Tripeptidyl aminopeptidase, Tripeptidyl-peptidase I, TPP-I.
What are the subcellular locations of this protein?
Lysosome. Melanosome.
Protein: UBL5_MESAU
Sequence: MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ
What are the official names of this protein?
Ubiquitin-like protein 5, Beacon protein.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL10_BRUMB
Sequence: MDRAEKREFVAWLNGAFKESGSVVVAHYTGLTVAQMSDLRSKMRDAGGSVKVAKNRLAKIALQGTESEGIADLFTGQTVVAYANDPITAPKVAVEFAKANDKLVILGGAMGATTLNADGVKSLASLPSLDELRAKLVGMIQTPAQRLAVLTSAPAGQIARVIGAHARKNEAA
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: APG_ARATH
Sequence: MKRSSLVDSCSYSRIFRSIFCLLSFCIFFLTTTNAQVMHRRLWPWPLWPRPYPQPWPMNPPTPDPSPKPVAPPGPSSKPVAPPGPSPCPSPPPKPQPKPPPAPSPSPCPSPPPKPQPKPVPPPACPPTPPKPQPKPAPPPEPKPAPPPAPKPVPCPSPPKPPAPTPKPVPPHGPPPKPAPAPTPAPSPKPAPSPPKPENKTIPAVFFFGDSVFDTGNNNNLETKIKSNYRPYGMDFKFRVATGRFSNGMVASDYLAKYMGVKEIVPAYLDPKIQPNDLLTGVSFASGGAGYNPTTSEAANAIPMLDQLTYFQDYIEKVNRLVRQEKSQYKLAGLEKTNQLISKGVAIVVGGSNDLIITYFGSGAQRLKNDIDSYTTIIADSAASFVLQLYGYGARRIGVIGTPPLGCVPSQRLKKKKICNEELNYASQLFNSKLLLILGQLSKTLPNSTFVYMDIYTIISQMLETPAAYGFEETKKPCCKTGLLSAGALCKKSTSKICPNTSSYLFWDGVHPTQRAYKTINKVLIKEYLHVLSK
What are the official names of this protein?
Anther-specific proline-rich protein APG.
What is the protein family that this protein belongs to?
Belongs to the 'GDSL' lipolytic enzyme family.
Protein: SSB2_ECOLX
Sequence: MAVRGINKVILVGRLGKDPEVRYIPNGGAVANLQVATSETWRDKQTGKMREQTEWHRVVLFGKLAEVAGEYLRKGAQVYIEGQLRTRSWEDNGITRYVTEILVKTTGTMQMLGRAAGAQTQPEEGQQFSAQPQPEPQSEAGTKKGGAKTKGRGRKVAQPEPQLQPPEGDDYGFSDDIPF
What is the function of this protein?
May contribute to the conjugative processing of DNA.  It has a functional relationship with Psi (plasmid-mediated sos inhibition) proteins.
What are the official names of this protein?
Plasmid-derived single-stranded DNA-binding protein, SSB, Helix-destabilizing protein.
Protein: ZNTC_DICDI
Sequence: MDIVNDLVSSISSISSEAAEEEAIRDELRNDKGGLIAGIFVLTLTASFVPWFLTKAKITNLVSVVSILTCLSAGVIIGAGFNHILPDAAEEFQSYVEAVAPDNKYGDFPFAHTITIVTMFALICVDKILVSGGLDGEADHNHMDLSQHNHPSPHAAGEIDLNIYTNGDDDDDDVNEDQEEDSTKDDEKEHGHGHGHGHGHNSSNSSSNGHGHGLKKKKKSKKEHGHGHNHDHSSNGHSHKDEKDSEKVNVSSKSKAWVFLVALSLHSIFDGLGLGSETQKDSFYGLLIAVLAHKFLDGLVLGIAIKYAYFSFKFSCIALVFAAAMTPLGIGIGMAISSAYESSTDAYLVKGIILSITCGSFIYISLIELLPSGLCQKGWPKLKLAVAFLGYSVMAILALWV
What is the function of this protein?
May transport divalent cations (By similarity).  May participate, with dstA, in the regulation of the differentiation of stalk cells during development.
What are the official names of this protein?
Protein zntC.
What is the protein family that this protein belongs to?
Belongs to the ZIP transporter (TC 2.A.5) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PEPA_ASPFC
Sequence: MVVFSKVTAVVVGLSTIVSAVPVVQPRKGFTINQVARPVTNKKTVNLPAVYANALTKYGGTVPDSVKAAASSGSAVTTPEQYDSEYLTPVKVGGTTLNLDFDTGSADLWVFSSELSASQSSGHAIYKPSANAQKLNGYTWKIQYGDGSSASGDVYKDTVTVGGVTAQSQAVEAASHISSQFVQDKDNDGLLGLAFSSINTVSPRPQTTFFDTVKSQLDSPLFAVTLKYHAPGTYDFGYIDNSKFQGELTYTDVDSSQGFWMFTADGYGVGNGAPNSNSISGIADTGTTLLLLDDSVVADYYRQVSGAKNSNQYGGYVFPCSTKLPSFTTVIGGYNAVVPGEYINYAPVTDGSSTCYGGIQSNSGLGFSIFGDIFLKSQYVVFDSQGPRLGFAPQA
What is the function of this protein?
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates.  The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site.  Shows a broad primary substrate specificity.  Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A.
What are the official names of this protein?
Aspergillopepsin-1, Aspartic protease pepA, Aspergillopepsin I, Aspergillopeptidase A.
What is the protein family that this protein belongs to?
Belongs to the peptidase A1 family.
What are the subcellular locations of this protein?
Secreted.
Protein: NUOC_CUPTR
Sequence: MAKLDTLKAALEKALGKRVQNLVEATGELTLIVKADDYLDVAQILRDDPSLRFEQLIDLCGVDYLEYADGAWDGPRFAAVSQLLSVTHNWRLRLRAFASDDDFPVLPSLINVWNSVNWFEREAFDFYGIVFDGHPDLRRILTDYGFVGHPFRKDFPVSGFVEMRYDPDQKRVIYQPVTIEPRELTPRVIREDKYGGVEH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: GUAC_SERP5
Sequence: MRIEEDLKLGFKDVLIRPKRSTLKSRSEVELERQFTFKHSGLSWSGVPIIAANMDSVGTFSMAEALASFDVLTAVHKHYTLEQWAAFVQRVPASVLRHVMVSTGTSEADFVKMQQILALSPGLKFICIDVANGYSEHFVAFLQKAREACPNHVICAGNVVTGEMVEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGQIVSDGGCSVPGDVAKAFGGGADFVMLGGMLAGHDECEGTVVEENGEKFMLFYGMSSESAMKRHVGGVAQYRAAEGKTVKLPLRGEVEFTVRDILGGLRSACTYVGAERLKELTKRTTFIRVAEQENRVFGSN
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Protein: MUTS2_THET8
Sequence: MRDVLEVLEFPRVRALLAERAKTPLGRELALALAPLPREEAEKRHELTGEALSYPYALPEAGTLREAYGRALAGARLSGPELLKAAKALEEAMALKEELLPLKNALSQVAEGIGDHTPFLERVRKALDEEGAVKDEASPRLAQIRRELRPLRQQILDRLYALMDRHREAFQDRFVTLRRERYCVPVRAGMAQKVPGILLDESESGATLFIEPFSVVKLNNRLQALRLKEEEEVNRILRDLSERLAKDEGVPKTLEALGLLDLVQAQAALARDLGLSRPAFGERYELYRAFHPLIPDAVRNSFALDEKNRILLISGPNMGGKTALLKTLGLAVLMAQSGLFVAAEKALLAWPDRVYADIGDEQSLQENLSTFAGHLRRLREMLEEATSHSLVLIDELGSGTDPEEGAALSQAILEALLERGVKGMVTTHLSPLKAFAQGREGIQNASMRFDLEALRPTYELVLGVPGRSYALAIARRLALPEEVLKRAEALLPEGGRLEALLERLEAERLALEAERERLRRELSQVERLRKALAEREARFEEERAERLKALEEEVRAELLKVEAELKALKEKARTEGKRDALRELMALRERYAKKAPPPPPPPGLAPGVLVEVPSLGKRGRVVELRGEEVLVQVGPLKMSLKPQEVKPLPEAEPGKPLLAKPRREVKEVDLRGLTVAEALLEVDQALEEARALGLSTLRLLHGKGTGALRQAIREALRRDKRVESFADAPPGEGGHGVTVVALRP
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.  Cleaves the phosphate backbone of oligodeoxynucleotides non-sequence-specifically at the 3' side of the phosphates.  Preferably incises the branched DNA structures, especially the D-loop structure over the Holliday junction.  Has ATPase activity.  Binds to dsDNA but not to ssDNA.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: R27A1_ENTH1
Sequence: MATRFRQTRRRRGHVSMGYGRIGKHRKQRGGRGNAGGQHHRKTWFTTFHPDYFGKHGMRVFHLKANKYYCPSINVDSLWSLVGKDVQAQYKNAKVGEEVPVIDCVKHGYFKVLGKGFLPKQPVIVRARYFSEKAQQKIKAVGGACELTA
What is the function of this protein?
Component of the large ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
What are the official names of this protein?
60S ribosomal protein L27a-1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: RNPA_GEOTN
Sequence: MKKKYRIKKNEEFQEVFRRGVSTANRQFVVYTLDRPEQPYFRIGLSVSKKLGKAVVRNQIKRYVRQCFLELKEEVVPGKDYVIIARQPVAEMGYAEVKKSLLHVLRKAGGLKKRGRTTDLA
What is the function of this protein?
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.  It can also cleave other RNA substrates such as 4. 5S RNA.  The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
What are the official names of this protein?
Ribonuclease P protein component, RNase P protein, RNaseP protein, Protein C5.
What is the protein family that this protein belongs to?
Belongs to the RnpA family.
Protein: CUL2_PONAB
Sequence: MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
What is the function of this protein?
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins.  CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.  The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.  The functional specificity of the ECS complex depends on the substrate recognition component.  ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).  A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation.  ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity).  ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity).
What are the official names of this protein?
Cullin-2, CUL-2.
What is the protein family that this protein belongs to?
Belongs to the cullin family.
Protein: CYCL_CLITE
Sequence: HEPCGESCVFIPCITTVVGCSCKNKVCYD
What is the function of this protein?
Probably participates in a plant defense mechanism.
What are the official names of this protein?
Cyclotide cter-L.
What is the protein family that this protein belongs to?
Belongs to the cyclotide family. Bracelet subfamily.
Protein: NU4LM_VICPA
Sequence: MSMVYMNIMLAFTMSLIGLLMYRSHLMSSLLCLEGMMLSLFVMASLMILSTHFTLASMMPIILLVFAACEAALGLALLVMISNTYGTDYVQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS13_DROME
Sequence: MGRMHAPGKGISQSALPYRRTVPSWLKLNADDVKEQIKKLGKKGLTPSKIGIILRDSHGVAQVRFVNGNKILRIMKSVGLKPDIPEDLYHMIKKAVAIRKHLERNRKDKDGKFRLILVESRIHRLARYYKTKSVLPPNWKYESSTASALVA
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
What are the official names of this protein?
40S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.