PharMolix/UniProtQA huggingface dataset:
Protein: MATK_PIPCE
Sequence: MEKFKRYLETFRSEQKYFLYPLLFQEYIYALGHDHGLNGPIPYESIENLGYGDKSSSLIVKRLIIRMHKQNHFLISCNENDFQQNRLLGRKNNLDSKIISEAFSIIVEIPFSFQLVSCLEKKREIAKSHNLRSIHSIFPFFEDNIFYLYHISDVLIPYPIHPEILVQTLRYWIQDVPSLHLLRIFLYEYCHSGSFISKKKFFSFSKKENERLSLFIYNSYVYEWESIFLFIRKQSSHLRSISWEALLERVHFYGKIEHLVVVLCNDFQKALWVFKDCFMHYVRYQGKSLLISKGTDLLMKKWKYHFIYLWQCNFHLWSQPHRIHINQLDNRSFHFLGYASSVRINLSVVKSQILENSFLMETSVKKFETTVPIISLIGSLSKEKFCNLSGHPTSKAIWADSSDSDIMERFGRVCRNLSHYYSGCSKKQILYRIKYILRLSCARTLARKHKSTVRVFLKRLGSGFLKEFLAEEEQVLSFFFPRSYPTSYRSNKDKERIWYLDITHTNDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RPOA_MYCSS
Sequence: MLISQRPTLSEETVADNRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTDIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHNPEMHIATLNDKGKLEVELVVERGRGYVPAVQNKASGAEIGRIPVDSIYSPVLKVTYKVEATRVEQRTDFDKLILDVETKNSITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPATFDPSEVAGYDAATGTWNSDAGYDLEDNQDYAETEQL
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
Protein: SECA_BURO1
Sequence: MTTGFLQKIFGSRNQRLVKQYQKTVATINALETQIEKLTDDQLRGKTDEFRQRVAAGESLDKLLPEAFAVCREASRRVLKMRHFDVQMIGGMVLHYGKIAEMRTGEGKTLVATLPVYLNALAGRGVHVVTVNDYLAQRDAEWMARLYNFLGLSVGINLSGMEHDQKQQAYAADITYGTNNEFGFDYLRDNMVYETDARVQRALNFAVVDEVDSILIDEARTPLIISGQAEDHTELYVRMNALPPLLERQIGEEKADGTGVEKPGDYTLDEKARQVFLTESGHEKAERLLAEWGLIGEGESLYAPQNITLMHHVYAALRAHTLFHKDQHYVVQNGEVVIVDEFTGRLMAGRRWSDGLHQAVEAKEHVKIQSENQTLASITFQNYFRMYAKLAGMTGTADTEAYEFNEIYGLETVVIPTNRPPKRIDKQDQIYKTAKERYDAVIRDIRDCYERGQPVLVGTTSIENSELLSHLLKQVGLPHEVLNAKQHEREAAIVAEAGRPKRITIATNMAGRGTDIVLGGNAEKQAAFIEADDAIPADEKARRIQKLHDEWETLHEEVKAAGGLHIIGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSLDDPLLRIFAGDRVRSIMDRLKMPEGEAIEAGIVTRSIESAQRKVEARNFDIRKQLLEYDDVSNDQRKVIYQQRNELLEAHDITETITAMRHGVITEVVRQFVPEGSIEEQWDVPELEEALRNDWQLDLAIQEMVNESSSITAEEILDAVMTAADEQYEAKVAMVGRESFSAFERSVMLQTVDRLWREHLAALDHLRQGIHLRGYAQKNPKQEYKREAFELFAAMLDAIKQEVTRIVMNVQIQSPEQLEEAAEQIEERGGHLENVEYQHADYADAGAPVANVTAAAAATATADMVGSAMTHSGPGGEMPKVGRNDPCPCGSGKKYKQCHGKLS
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
Protein: HGD_RHOPS
Sequence: MNVNAAPEIVGRASQGVTPGYMSGFGNSFETEALPGALPVGRNSPQRAAYGLYAEQLSGSPFTAPRGANERSWLYRIRPSVKHSGRFAKADMGLWRSAPCLEHDMPIAQLRWDAPPMPTEEVTFVQGVRTMTTAGDVNTQAGMAAHMYLISRSMVDQHFYNADGELMFVPQQGRLRLVTEFGVIAIEPAEIAVIPRGVKFRVELVDGPARGYLCENYGGAFTLPERGPIGANCLANSRDFLTPVASYEDKDTPTELFVKWGGALWRTSLPHSPIDVVAWHGNYAPYKYDLRTFSPVGAIGFDHPDPSIFTVLTSPSETAGTANIDFVIFPERWMVAENTFRPPWYHMNIMSEFMGLIYGVYDAKPQGFAPGGASLHNMMLPHGPDREAFDHASNGELKPVKLTGTMAFMLETRYPQRVTEYAATADTLQDDYADCWRGLEKRFDPSRP
What is the function of this protein?
Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine.  Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
What are the official names of this protein?
Homogentisate 1,2-dioxygenase, HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase.
What is the protein family that this protein belongs to?
Belongs to the homogentisate dioxygenase family.
Protein: RL11_BRUAB
Sequence: MAKKVAGQLKLQVPAGAANPSPPIGPALGQRGINIMEFCKAFNAASQEMEKGSPIPVLITYYQDKSFTFVMKTPPVTYFLKKAANLKSGSKTPGKASAGTITRDKVRAIAEAKMKDLNAADVEAAMRMIEGSARSMGLEVVG
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: TP1C_LITCL
Sequence: FLPFLASLLTKVL
What is the function of this protein?
Antibacterial activity against Gram-positive bacterium S. aureus.
What are the official names of this protein?
Temporin-1Cc.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ARGB_CITBB
Sequence: MQQLIEKASTLMEALPYIRRFSGKTIVIKYGGHAMADEKLRKSFALDVILLKYIGINTVVVHGGGPQINETLKRYGIVSEFVKGMRVTDKETMGVVEMVLTGQVNREVVGYINQNGGRAAGLSGKDGDLLICEKLLQEVKSEDGSTETVDIGFVGDVVEVNPAILQALEKGGFIPVIAPVGVGRAGESYNINADVVAGKVAAALNAEKLILLTDVSGVKSKEGELLSSIPLADVPALIDNGTVTGGMIPKVTCCTDALAAGVKKAHIVDGRIEHAILLEIFTNVGIGTEIQA
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
What are the official names of this protein?
Acetylglutamate kinase, N-acetyl-L-glutamate 5-phosphotransferase, NAG kinase, NAGK.
What is the protein family that this protein belongs to?
Belongs to the acetylglutamate kinase family. ArgB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLMS_METTH
Sequence: MCGIVACILKDGSAAPVLLECVRRLEYRGYDSVGIATSDPMIRIKKDSGKIDEVDAELDLADLPGTMGIAHVRWATHGLPTAENAHPHTDCSGEIAVVHNGIIENYLEVKEELESEGHIFRSETDTEVIPHLIEKYMDEGMDLEAATATALRKLRGAYAIAAVSSREPGRIVGARKESPLIVGVGEGEYFLASDVPAILNHTSRVIYLDDGEMVILDGDLRVTDMEGNTVEKEVHSIDWSADMAEKGGYDHFMLKEIHEEPSAVRDTLTEWDEVLGVVEEIGEVERICFVACGTSYHASLVGKYLFESLLGIPTDVILASEFRYSAGALNDRTLAIFISQSGETADTLNALRAANSRAKTLAIVNVLGSSATREAQHVLYTRAGPEIGVAATKTYVSQLTVIYMLVAAMGAPELMDRLERVPEFMERALEDEDGIKELAATCSDVSDFFFIGRGFAYPTALEGALKLKEITYIHGEGYAAGELKHGPLALIDNGVPVVAISPPGPCHDKTLSNVEEVRARGARVIGVGSISDESLRKEADDFIGLDPEVDDVISPLVYIVPLQLLSYHVSVERGLDPDKPKNLAKCVTVE
What is the function of this protein?
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
What are the official names of this protein?
Glutamine--fructose-6-phosphate aminotransferase [isomerizing], D-fructose-6-phosphate amidotransferase, GFAT, Glucosamine-6-phosphate synthase, Hexosephosphate aminotransferase, L-glutamine--D-fructose-6-phosphate amidotransferase.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJFL_ECOLI
Sequence: MHILDSLLAFSAYFFIGVAMVIIFLFIYSKITPHNEWQLIKNNNTAASLAFSGTLLGYVIPLSSAAINAVSIPDYFAWGGIALVIQLLVFAGVRLYMPALSEKIINHNTAAGMFMGTAALAGGIFNAACMTW
What are the official names of this protein?
UPF0719 inner membrane protein YjfL.
What is the protein family that this protein belongs to?
Belongs to the UPF0719 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: IOLG_PSESM
Sequence: MALKLGVIGTGAIGQDHIRRCSKTLVGSQVVAVTDINLEQAANVVRDLGIGAEVYADGHALIAAPDVEAVLVCSWGPSHEEYVLAAIAAGKPVFCEKPLAVTAEGCRHIVEAEIASGRRLVQVGFMRPYDQGYRALKSVIDSGQIGEPLMLHCAHRNPRVGENYKTDMAITDTLIHELNVLRWLLNDDYVSVQVVFPRKSGKALAHMKDPQIVMLETARGTRIDVEVFVNCQYGYDIQCEVVGESGIARLPEPSQVQLRREAKLSNAILMDWKDRFIAAYDVELQDFIDGVKAGTIYGPSAWDGYAAAVAADACVLAQNNGAVVPITLAMRPAFYA
What is the function of this protein?
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
What are the official names of this protein?
Inositol 2-dehydrogenase, Myo-inositol 2-dehydrogenase, MI 2-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the Gfo/Idh/MocA family.
Protein: LSPA_SULDN
Sequence: MHNKTVRHLTILILTIAGIFIIDQNIKSLFVDGYRYYSDCIDLILVYNKGVAFSMFAFLDESLKYIQLVLVFGVFGYMLYLNQLCYAIPAGLMLGGAFSNIYDRFIHGGVVDMVYWHCGFDFAVFNFADVMIDVAVVWILLLNFKPKFCKNHS
What is the function of this protein?
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
What are the official names of this protein?
Lipoprotein signal peptidase, Prolipoprotein signal peptidase, Signal peptidase II, SPase II.
What is the protein family that this protein belongs to?
Belongs to the peptidase A8 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: LYPA2_MOUSE
Sequence: MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRTVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
What is the function of this protein?
Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (By similarity).  Deacylates GAP43 (By similarity).  Mediates depalmitoylation of ZDHHC6 (By similarity).  Has lysophospholipase activity (PubMed:10064901).  Hydrolyzes prostaglandin glycerol esters (PG-Gs) (PubMed:25301951).  Hydrolyzes PG-Gs in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (By similarity).  Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (By similarity).
What are the official names of this protein?
Acyl-protein thioesterase 2, APT-2, Lysophospholipase 2, Lysophospholipase II, LPL-II, LysoPLA II, mLyso II, Palmitoyl-protein hydrolase.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RABP1_MOUSE
Sequence: MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLPTWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE
What is the function of this protein?
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
What are the official names of this protein?
Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP71_HCMVT
Sequence: MSQASSSPGEGPSSEAAAISEAEAASGS
What is the function of this protein?
Stimulates viral immediate-early (IE) transcription.  Counteracts the DAXX-mediated repression of viral transcription.  Displaces a DAXX-binding protein, ATRX, from nuclear domain 10 sites (ND10) shortly after infection (By similarity).
What are the official names of this protein?
71 kDa phosphoprotein, pp71, 71 kDa upper matrix phosphoprotein, Phosphoprotein UL82, ppUL82, Tegument protein UL82.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae pp71 family.
What are the subcellular locations of this protein?
Virion tegument. Host nucleus. Note=Present in the nucleus shortly after infection as well as during the late phase of viral morphogenesis. Detected at nuclear domain 10 (ND10). Also found in dense bodies (By similarity).
Protein: RIMK_ECO81
Sequence: MKIAILSRDGTLYSCKRLREAAIQRGHLVEILDPLSCYMNINPAASSIHYKGRKLPHFDAVIPRIGTAITFYGTAALRQFEMLGSYPLNESVAIARARDKLRSMQLLARQGIDLPVTGIAHSPDDTSDLIDMVGGAPLVVKLVEGTQGIGVVLAETRQAAESVIDAFRGLNAHILVQEYIKEAQGCDIRCLVVGDEVVAAIERRAKEGDFRSNLHRGGAASVASITPQEREIAIKAARTMALDVAGVDILRANRGPLVMEVNASPGLEGIEKTTGIDIASKMIRWIERHATTEYCLKTGG
What is the function of this protein?
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF).  Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate.  The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH.
What are the official names of this protein?
Ribosomal protein S6--L-glutamate ligase, Poly-alpha-glutamate synthase, Ribosomal protein S6 modification protein.
What is the protein family that this protein belongs to?
Belongs to the RimK family.
Protein: TIP21_ORYSJ
Sequence: MVKLAFGSLGDSFSATSVKAYVAEFIATLLFVFAGVGSAIAYGQLTNGGALDPAGLVAIAIAHALALFVGVSVAANISGGHLNPAVTFGLAVGGHITILTGLFYWIAQLLGASIACLLLKFVTHGKAIPTHGVAGISELEGVVMEIVITFALVYTVYATAADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVAAGNFAGNWVYWVGPLIGGGLAGLVYGDVFIGSYQPVADQDYA
What is the function of this protein?
Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.  May be involved in transport from the vacuolar compartment to the cytoplasm (By similarity).
What are the official names of this protein?
Probable aquaporin TIP2-1, Tonoplast intrinsic protein 2-1, OsTIP2;1.
What is the protein family that this protein belongs to?
Belongs to the MIP/aquaporin (TC 1.A.8) family. TIP (TC 1.A.8.10) subfamily.
What are the subcellular locations of this protein?
Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast.
Protein: GCST_LISMF
Sequence: MTELLKTPIHPLYAKYGAKTIDFGGWDLPVQFAGIKAEHEAVRTDAGLFDVSHMGEILVKGPDSTSYLQYLLTNDIEKIKIGKAQYNIMCYETGGTVDDLVVYKKSETEYILVVNAANTDKDFEWMVKNIRGDVSVTNVSSEYGQLALQGPSAEKILAKLTDVDLSSISFFGFVEDADVAGVKTIISRSGYTGEDGFEIYMPSADAGKVFEAILAEGVAPIGLGARDTLRLEAVLALYGQELSKDITPLEAGLNFAVKLKKEADFIGKEALIKQKEAGLNRKLVGIELIERGIPRHDYPVFLNEEEIGIVTSGTQSPTLGTNIGLALIDTAYTEIGQEVEVGIRNKKIKAKIVPTPFYKRAK
What is the function of this protein?
The glycine cleavage system catalyzes the degradation of glycine.
What are the official names of this protein?
Aminomethyltransferase, Glycine cleavage system T protein.
What is the protein family that this protein belongs to?
Belongs to the GcvT family.
Protein: PDE6D_CANLF
Sequence: MSAKDERAREILKGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSAEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
What is the function of this protein?
Promotes the release of prenylated target proteins from cellular membranes (By similarity).  Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (By similarity).  Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity).  Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity).  Increases the affinity of ARL3 for GTP by several orders of magnitude.  Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).
What are the official names of this protein?
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, GMP-PDE delta.
What is the protein family that this protein belongs to?
Belongs to the PDE6D/unc-119 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, cilium basal body.
Protein: CSN3_XENLA
Sequence: MASALEQFVNSVRQLSSQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSIPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGICVIRQAIDKMQMNANQLTSIHGDLCQLSLLAKCFKPALAYLDVDMMDICKENGAYDAKPFLCYYYYGGMIYTGLKNFERAMYFYEQAITTPAMAVSHIMLEAYKKYILVSLILHGKVQQLPKYTSQVVGRFIKPLSNAYHELAQVYSTNNPAELRNLVSKHNETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGAQEAEKYVLYMIEDGEIFASINQKDGMVCFHDSPEKYNNPAMLHNIDQEMLRCIDLDDRLKAMDQEITVNPQFVQKSMGSQEDDSGSKPSSYS
What is the function of this protein?
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity).  The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
What are the official names of this protein?
COP9 signalosome complex subunit 3, Signalosome subunit 3.
What is the protein family that this protein belongs to?
Belongs to the CSN3 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: GSS1_ZYMTI
Sequence: MDKFSQSPPLRDDLVRGSSLNWTKEKENILKGPFNYLESHPGKDIRSQLIAAFNAWLDVPEESLNVIRRVVAMLHTASLLIDDVEDNSQLRRGIPVAHNVFGTAQTINSANYVYFCALKELAILNNPAVIQIYTEELVNLHRGQGMDLFWRDTLTCPSEDDYLEMVGNKTGGLFRLAIKLMCAESPSHNAHPDPFQRNDYVPLVNTIGLLFQILDDYKNLSDTIYTQNKGLCEDLTEGKFSFPIIHAIRADPGNLVLINILKQKTTDDEVKKYAVAYMDRAGSFSYTRKVLRGLTKKALTQVDEVDAGRGRGEQMKTILEKLRVDRNHQRGVLTPAAGGASIA
What is the function of this protein?
Geranylgeranyl pyrophosphate synthase; part of the gene cluster 4 that mediates the biosynthesis of an isoprenoid secondary metabolite.
What are the official names of this protein?
Geranylgeranyl pyrophosphate synthase 1, GGPP synthase 1, GGPPSase 1, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase.
What is the protein family that this protein belongs to?
Belongs to the FPP/GGPP synthase family.
Protein: MSCL_STAES
Sequence: MLKEFKEFALKGNVLDLAIAVVMGAAFNKIVTSLVQYIIMPLIGKLFGSVNFAEDWSFWGIKYGLFIQSIIDFIIIAFALFIFVKIANTVMKKEEKEEEVEENTVLLTEIRDLLKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: SRG2B_HUMAN
Sequence: MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTCSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELLQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTVRECYGF
What is the function of this protein?
May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692, PubMed:31822692).  In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692).
What are the official names of this protein?
SLIT-ROBO Rho GTPase-activating protein 2B, SLIT-ROBO Rho GTPase activating protein 2 pseudogene 2.
Protein: HIS4_RHOCS
Sequence: MNIYPAIDLKDGQAVRLLRGDMDQATVFNPDPAAQAAAFQDQGFRWLHLVDLNGAFAGRPVNADAVSRILERVTIPVQLGGGIRDMATIEEWLGRGIRRVILGTVALRDPDLVKDACRAFPGRICVGIDARDGHVAVEGWATTSDVRALDLALRFEDAGVAAIVYTDINRDGAMGGVNVEATADLAVHLTTPVIASGGVHALSDLLALKAEAETGIEGVIVGRALYDGRIDPRQALALTAGPEDARC
What are the official names of this protein?
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DM7B_DROME
Sequence: MAKRGKKGGIPRAEMVQVASANRDENQVTELKKADYLPYLFNLVMPKMFFKSPNRIVMARLYPDVHKHDQQSAEYFEGFQAPCFDLPASLFPDNAPIDKIVFMPTVMLPMGFEAGGVFGPGVLPRDCYPVDLIRTEHEGPMPPLFVGLRSMNISLASMIDSFLDMYDNPEGEDAFVYEMHATDHHYDDDITEELMLRPDFTLSVAYSLPATMRLPSPYPYPCVQAQDNIYTPDLSKVLMLMPHQLNITVSILSTVNNPHVPSVAFATMCDEEECPTFDLPTDVFPICEGVNRPIFLPKRFMPKGFEACCVFKPGSLSELWFIKRIGRFGTPQQQHNCTITPPLFVGKYSRDGECTDMIEEIRMNFDKKARESAKSIASLTLETLGGLSRHITSTKGFLVMESDKPTPPAGAYSVESYEEASEDGCIAKVTKECASKITDTRDDGINTADYQSQFPELEPEPEPEPEDEGEDVANKKKCLSCFKIDSDIDVMSHAIAELTVAELSMLGEENPVPGVDTELALDQLREVLENRGEIRSNTDDLMRDHIYRMERDLMLALRQPIRKCCECTVNF
What are the official names of this protein?
DM7 family protein CG15332.
What is the protein family that this protein belongs to?
Belongs to the DM7 family.
Protein: FZ10A_XENLA
Sequence: MDVSGVTGLLRGTALLLVLAAALCSAISSINPDRSGDGRCQAIEIPMCKDIGYNMTRMPNLMGHENQKEAAIQLHEFAPLVEYGCHSHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCSKLPNKNDPNYLCMEAPNNGTDETPRGSSMLPPIFRPQRPSSGHEIYPKDPTSRSSCENSGKFHHVEKSASCAPLCSSSVDVYWSKDDKKFAFIWIAIWSILCFFSSAFTVLTFLVDPLRFKYPERPIIFLSMCYCVYSVGYIIRLFAGADSIACDRDSGQLYVIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTIMILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLIIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDFWKILATQDKCKMDSQTKTLDCTMTSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTVQSWQNVFSKRLKKRNRSKPASVITSAGIYKKPQHPPKVHHGKYESALQSPTCV
What is the function of this protein?
Receptor for Wnt proteins.  Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.  A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase.  Both pathways seem to involve interactions with G-proteins.  May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.  Activated by Wnt8.  Could have an antagonizing activity in the morphogenesis during development.
What are the official names of this protein?
Frizzled-10-A, Fz-10A, Xfz10-A.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor Fz/Smo family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y3655_SHEFN
Sequence: MEKVFERLMYASRWIMAPIYLGLSLILFALGIKFFQEIFHIIPNIFSIKEVDLVLITLSLIDITLVGGLLIMVMFSGYENFVSQLDVGENSEKLNWLGKMDAGSLKNKVAASIVAISSIHLLKVFMNAENIANDKIMWYLLIHITFVLSAFAMGYLDKITRK
What are the official names of this protein?
UPF0114 protein Sfri_3655.
What is the protein family that this protein belongs to?
Belongs to the UPF0114 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YBEM_ECOLI
Sequence: MMTTILTIHVPSTPGRAWNMLVALQAGNIVARYAKLHLYDAFAIQESRRVDAGNEIAPLLEVEGMKVGLMTCYDLRFPELALAQALQGAEILVLPAAWVRGPLKEHHWSTLLAARALDTTCYMVAAGECGNKNIGQSRIIDPFGVTIAAASEMPALIMAEVTPERVRQVRAQLPVLNNRRFAPPQLL
What is the function of this protein?
Pseudogene resulting from a nucleotide deletion that introduces a premature stop codon at position 66.  This is the C-terminal fragment.  The intact protein (AC A0A140NCB4) hydrolyzes deaminated glutathione (dGSH, 2-oxoglutaramate) to alpha-ketoglutarate (alpha-KG) and cysteinylglycine, has less activity against alpha-ketoglutaramate (a-KGM) and no activity on glutathione or L-glutamine (By similarity).  May function as a metabolite repair enzyme (By similarity).
What are the official names of this protein?
Putative protein YbeM.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.