PharMolix/UniProtQA huggingface dataset:
Protein: PEPT_LATSS
Sequence: MAKYEKLIPRFLEYITTETRSDENATTIPSTQTQVVFLHKLMDDLKEIGLSDVKYNEKNGYVTALLPSNIDKKVPTMGFLSHVDTADFNAKGVNPQTIENYDGESIIKLDEAGQFVLDPKEFPNMKNYKGQTLITTDGSTLLGSDDKSGVAEIITAMDYFIQHPEIKHGDIKIGLGPDEEIGTGADHFDAEDFATDFAYTMDGGPIGQLEYETFNAAAMKVDIQGKNVHPSEAKDIMINALQVAVDFQDAFPRDEVPEKTDGRQGFYHLLSLDGTVDEAHMAYIIRDFDRDGLETRKAFAAKVAEDMNAKYGEGRVKATIKDQYYNMAEVLKDHMDVVDLAKDAMEAIDIKPLIEPVRGGTDGSKISFMGIPTPNIFAGAENMHGRYEFVSVQTMEKAVDTMIKMNELNVERN
What is the function of this protein?
Cleaves the N-terminal amino acid of tripeptides.
What are the official names of this protein?
Peptidase T, Aminotripeptidase, Tripeptidase, Tripeptide aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M20B family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MRP4_RAT
Sequence: MLPVHTEVKPNPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRAKKDARKPSLTKAIVKCYWKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHTAYGYAAVLSLCTLILAILHHLYFYHVQCAGMRIRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLSNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKNFLLLDELPERKAQEPSDGKAIVHVQDFTAFWDKALDTPTLQGLSFTARPGELLAVVGPVGAGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEKERYEKVIKACALKKDFQLLEDGDRLVIGDRGARLSGGQKARVNLATAVYQDADIYLLDDPLSAVDAEVGKHLFQLCICQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSPVPGTPTLRNRTFSEASIWSQQSSRPSLKDGVPDAQDAENTQAAQPEESRSEGRIGFKAYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNVTGTLDLSWYLGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGSLVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECRKRPPPGWPHEGVIVFDNVNFTYSLDGPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLLQNPESLFYKMVQQLGKGEAAALTETAKQVYFRRNYPDIAFSSPAVMSTSNGQPSALTIFETAL
What is the function of this protein?
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells.  Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins.  Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4).  The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4.  Mediates the cotransport of bile acids with reduced glutathione (GSH).  Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules.
What are the official names of this protein?
ATP-binding cassette subfamily C member 4, Multidrug resistance-associated protein 4.
What are the subcellular locations of this protein?
Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Its localization to the basolateral or apical membranes is tissue-dependent.
Protein: URE2_MYCTU
Sequence: MIPGEIFYGSGDIEMNAAALSRLQMRIINAGDRPVQVGSHVHLPQANRALSFDRATAHGYRLDIPAATAVRFEPGIPQIVGLVPLGGRREVPGLTLNPPGRLDR
What are the official names of this protein?
Urease subunit beta, Urea amidohydrolase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the urease beta subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GGH1_ARATH
Sequence: MIDNNCLYKEELNRNSYSGLAKEASESILLPSESGFDGSRSPVCSSPDPNLNYRPVIGILSHPGDGASGRLTNDTSSTYIAASYVKFAEAGGARVIPLIYNEPEEVLFQKLELVNGVIFTGGWAKKYDYFEIVKKIFTKALERNDAGEHFPVYGICLGFELMSIIISQNRDILERFDAEDNASSLQFVDNVNNDGTLFQRFPPELLKKLSTDCLVMQKHKYGITPANFQANPALSSFFEILTTCIDENSKTYVSTVKAKRYPITGFQWHPEKNAFEWGSSAIPHSEDAIQVTQHAASYLVSEARKSLNRPESQKVLSNLIYNYKPTYCGYAGRGYDEVYIFTQPRSRF
What is the function of this protein?
Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole.  Is important for polyglutamyl tail length determination before vacuolar exit.  Plays a role in folate stability and intracellular folate content.
What are the official names of this protein?
Gamma-glutamyl hydrolase 1, AtGGH1, Conjugase, GH, Gamma-Glu-X carboxypeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C26 family.
What are the subcellular locations of this protein?
Vacuole. Secreted, extracellular space. Secreted, cell wall. Note=Extracellular or cell-wall bound.
Protein: BETI_ECODH
Sequence: MPKLGMQSIRRRQLIDATLEAINEVGMHDATIAQIARRAGVSTGIISHYFRDKNGLLEATMRDITSQLRDAVLNRLHALPQGSAEQRLQAIVGGNFDETQVSSAAMKAWLAFWASSMHQPMLYRLQQVSSRRLLSNLVSEFRRELPREQAQEAGYGLAALIDGLWLRAALSGKPLDKTRANSLTRHFITQHLPTD
What is the function of this protein?
Repressor involved in the biosynthesis of the osmoprotectant glycine betaine.  It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).
What are the official names of this protein?
HTH-type transcriptional regulator BetI.
Protein: UD3A1_XENLA
Sequence: MAVGRKSLILSLLIQHFVLLHGAKILTVCFLGGSHYLWMDEISRILHNNGQEVTMFLQIADGLLPDYQMQESPYRLITWSLDKNYLKEFSEFFRDSKYNFKDCDELSSYLGLMTHFSRQCKMIFNQTSIMNLLKEEKYDLAVIDSFNPCTFLVSEKLGIPFIATHPFPVKSPWHSGIPNQLSYMPVYQSQLTDHMDFFERVKNVFMYIASAVLERKIYSLFDDVIEEHFPACSRPSFEELYKKTALWMYLTDFTIEFPHPFFPNVLYIGGVLAKPAKPVSEELEDFIAQSGEHGFIIVTFGSMVPSNPLTEFVKEMNDGFSKIPQKVIWRYRISEWPKVLQLAPNVKIMNWISQNDLLGHPKARLLVTHGGVNSIQEAIYHGVPMVAIPLFFDQFDNAVRIKAKHLGTFIPKDQLKAEKLANAIRDVIGGESYKNSAMHLSLIQRSQPFPKDQQIVRWVEHIVKVGGTDHLIPYSYQQPLYQQYLLDVFLFVCVCVIGACYLTVKLLKMFIQKLCSFRKLKQN
What is the function of this protein?
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion.  They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
What are the official names of this protein?
UDP-glucuronosyltransferase 3A1, UDPGT 3A1.
What is the protein family that this protein belongs to?
Belongs to the UDP-glycosyltransferase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL18_MYCS5
Sequence: MNLSRNKARKVKQKRLRAKSELSRAASKPRLSVFKSHANFYAQLIDDQKRVTLASVSSLKSGKYGGNVAAAKELGLLMGQKILDLKLETVAFDRNGYLYHGRVKAFADAVREKGVKF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: GET1_CANGA
Sequence: MSWVVAIAVVFVVVLKVLEYSTSYHDLVLQSLFFKNSPISVKFETLVKERRSIQEENKSISAQDNYAKWTKNNRKLDKLDKEITELGAQLKAHNEQIKGHLKKVKLLLLTVPFLCFKLWKGKHIVYNLPHHQMFPQLVAGVWSQGWLYLAILPLQLAKSIVTGSSFAIETASFPHMGVSLGIWLWALNSVISNIEFMTMQLWAKPVSKPSKKLEIVTDEIKVD
What is the function of this protein?
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum.  Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.  The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
What are the official names of this protein?
Golgi to ER traffic protein 1, Guided entry of tail-anchored proteins 1.
What is the protein family that this protein belongs to?
Belongs to the WRB/GET1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Protein: TP8L3_MOUSE
Sequence: MDSDSGEQSEGEPGTAAGPHVFSSKNLALQAQKKILSKIASKTVANMLIDDTSSEIFDELYKVTEIHTHNKKEAHKIMKDAIKVAIKIGILYRNKQFSQEEVIIVEKLRKKLNQTAMTMVSFYEVEYTFDTNVLSKLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYGPHGNCRPNLKRICEGINKLLDDKIL
What is the function of this protein?
Acts as a lipid transfer protein.  Preferentially captures and shuttles two lipid second messengers, i. e. , phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane.  Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways.  May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
What are the official names of this protein?
Tumor necrosis factor alpha-induced protein 8-like protein 3, TNF alpha-induced protein 8-like protein 3, TNFAIP8-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the TNFAIP8 family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane. Note=On PDGF activation, translocates from cytoplasm to plasma membrane.
Protein: RSMA_MESH7
Sequence: MQKPVPKKHLGQNFLKDRKIAEKIVENIDLKNKEIIEIGCGTGFLTNFLLERAKFVTCYEIDRNLIPILEKKFKNKNLRIINEDFLLAELEFKEKKTIIANLPYYITSKILFKIFANFEKFDKIILMVQNEVADRIVAKPKTPTYSKLSLASQYIADVKKLFVVGPDSFFPKPKVNSAVVLFDFRENLEAKKMEEFFWFTKKCFQFKRKTLYNNLIFFLNKQQIEKIYNFFQFAQNIRPQQLDLVTYIRLADFYFNNIF
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATS7_RAT
Sequence: MHRGLNLLLILCALAPHVLGPASGLPTEGRAGLDIVHPVRVDAGGSFLSYELWPRVLRKRDVSAAQASSAFYQLQYQGRELLFNLTTNPYLLAPGFVSEIRRRSNLSNVHIQTSVPTCHLLGDVQDPELEGGFAAISACDGLRGVFQLSNEDYFIEPLDEVPAQPGHAQPHMVYKHKRSGQQDDSRTSGTCGVQGSPELKHQREHWEQRQQKRRQQRSISKEKWVETLVVADSKMVEYHGQPQVESYVLTIMNMVAGLYHDPSIGNPIHITVVRLIILEDEEKDLKITHHADDTLKNFCRWQKNVNMKGDDHPQHHDTAILLTRKDLCATMNHPCETLGLSHVAGLCHPQLSCSVSEDTGLPLAFTVAHELGHSFGIQHDGTGNDCESIGKRPFIMSPQLLYDRGIPLTWSRCSREYITRFLDRGWGLCLDDRPSKGVINFPSVLPGVLYDVNHQCRLQYGPSSAYCEDVDNVCYTLWCSVGTTCHSKMDAAVDGTSCGKNKWCLNGECVPEGFQPETVDGGWSGWSAWSVCSRSCGVGVRSSERQCTQPVPKNKGKYCVGERKRYRLCNLQACPPDRPSFRHTQCSQFDSMLYKGKLHKWVPVLNDENPCELHCRPFNYSNREKLRDAVMDGTPCYQGRISRDICIDGICKKVGCDFELDSGAEEDRCGVCRGDGSTCHTVSRTFKEAEGMGYVDVGLIPAGAREILIEEVAEAANFLALRSEDPDKYFLNGGWTIQWNGDYQVAGTTFTYTRKGNWETLTSPGPTTEPVWIQLLFQERNPGVHYKYTIQRASHSEAQPPEFSWHYGPWSKCPVTCGTGVQRQSLYCMEKQAGIVDEGHCDHLSRPRDRKRKCNEEPCPARWWVGDWQPCSRSCGPGGFFRRAVFCTRSVGLDEQRALEPSACGHLPRPLAEIPCYHYVACPSSWGVGNWSQCSVTCGAGIRQRSVLCINNTGVPCDGAERPITETFCFLQPCQYSTYIVDTGASGSGSSSPELFNEVDFDPHQPVPRPSPASSPKPVSISNAIDEEDPELDPPGPVFVDDFYYDYNFINFHEDLSYGSFEESHSDLVDIGGQTVPPHIRPTEPPSDSPVPTAGAPGAEEEGIQGSWSPSPLLSEASHSPPVLLENTPVNPLANFLTEEESPIGAPELGLPSVSWPPASVDGMVTSVAPGNPDELLVREDTQSQPSTPWSDRNKLSKDGNPLGPTSPALPKSPFPTQPSSPSNSTTQASLSPDAVEVSTGWNVALDPVLEADLKPVHAPTDPGLLDQIQTPHTEGTQSPGLLPRPAQETQTNSSKDPAVQPLQPSLVEDGAPTDLLPAKNASWQVGNWSQCSTTCGLGAIWRLVRCSSGNDEDCTLSSRPQPARHCHLRPCAAWRAGNWSKCSRNCGGGSATRDVQCVDTRDLRPLRPFHCQPGPTKPPTRQLCGTQPCLPWYTSSWRECSEACGGGEQQRLVTCPEPGLCEESLRPNNTRPCNTHPCTQWVVGPWGQCSAPCGGGVQRRLVKCVNTQTGLAEEDSDLCSHEAWPESSRPCATEDCELVEPSRCERDRLPFNFCETLRLLGRCQLPTIRAQCCRSCPPLSRGVPSRGHQRVARR
What is the function of this protein?
Metalloprotease that may play a role in the degradation of COMP.
What are the official names of this protein?
A disintegrin and metalloproteinase with thrombospondin motifs 7, ADAM-TS 7, ADAM-TS7, ADAMTS-7, COMPase.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix. Note=Also found associated with the external cell surface.
Protein: NQRD_SHESW
Sequence: MSDAKELKQVLTGPIVNNNPIALQILGVCSALAVTSKLETALVMALALTAVTAFSNLFISLIRNHIPSSVRIIVQMTIIASLVIVVDQLLQAYAYQISKQLSVFVGLIITNCIVMGRAEAYAMKTPPMMSFMDGIGNGLGYGVILLAVGFVRELFGNGSLFGVQILHKISEGGWYQPNGMLLLPPSAFFLIGILIWIIRTYKPEQVEAKG
What is the function of this protein?
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm.  NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
What are the official names of this protein?
Na(+)-translocating NADH-quinone reductase subunit D, Na(+)-NQR subunit D, Na(+)-translocating NQR subunit D, NQR complex subunit D, NQR-1 subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrDE/RnfAE family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HSLU_SULSY
Sequence: MEIDKELTPKQIVEELNKYIVGQYEAKKAVAVALRNRWRRQKLPEDLRDEVIPKNILMIGPTGVGKTEIARRLANLVKAPFIKVEATKFTEVGYVGRDVESIIRELVDVSFKMVKAEKMEEVREKAKAIAEEKILDYLVPKKPKRYGTLIEEEEESPAREKFREMLKNGQLDDKVVEIDVEEKVSAVVGGVVVPGLEDIESQLKELFSNLGPSKRKKRRLTVKEALKIIENEEAEKLIDMDEVQTLAVKRAENLGIVFIDEIDKVAARGSSKSGPDVSREGVQRDLLPIVEGTVVSTKYGPVKTDHILFIAAGAFHLAKPSDLIPELQGRFPIRVELKALTKDDFVKILTEPKNALIKQYIALMSTEGVELEFTEDAIQEIAQIAEEVNERTENIGARRLHTILERIMEDYSFNAPDLKGQKIVIDSKLVREKLGNVITNEDLTRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMP11_RAT
Sequence: MARAACLLRAISRALLLPLPLLLLLLLLLPPQLMARARPPENHRHRPVKRVPQLLPAALPNSLPSVPASHWVPGPASSSRPLRCGVPDPPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALRVWSEVTPLTFTEVHEGRADIMIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDKGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQLTPTSPTPTLSSQAGTDTNEIALQEPEVPPEVCETSFDAVSTIRGELFFFKAGFVWRLRSGQLQPGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVHAALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRTTDWRGVPSEIDAAFQDAEGYAYFLRGHLYWKFDPVKVKVLESFPRPIGPDFFDCAEPANTFR
What is the function of this protein?
May play an important role in the progression of epithelial malignancies.
What are the official names of this protein?
Stromelysin-3, SL-3, ST3, Matrix metalloproteinase-11, MMP-11.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: RPPH_CERSK
Sequence: MERTIDPLTLPYRPCVGIVLINREGLIFAGQRIDSPVPAWQMPQGGIDEGEKPREAALRELWEETGIPAERVEFVAKAPDWVTYDLPPELLGRVWGGKYRGQRQKWFLYRYLGTDEEVGIGTDHAEFSCWRWIGAEEMVAAIVPFKRAVYEEVVATFRPHLA
What is the function of this protein?
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
What are the official names of this protein?
RNA pyrophosphohydrolase, (Di)nucleoside polyphosphate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the Nudix hydrolase family. RppH subfamily.
Protein: RL2_ALBFT
Sequence: MAVIKMKPTSPGRRGVVKISRDHLYKGEPFAPLLEPQFQHAGRNNNGHITTRHKGGGHKHHYRVVDFLRTKDGIPAKVERIEYDPNRSAHIALVCYADGERRYIIAPRGLEVGASIMSGAEAPIRVGNTLPIRNIPVGSIVHCIELQIGKGAQIVRSAGTSATLLAREGIYAQVRMRSGEVRKIHIECRATLGQVANEEHSLRRLGKAGAKRWKGIRPTVRGVVMNPVDHPHGGGEGKTGEGRHPVDPWGNLTKGYRTRNNKRTQVMIVSRRKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DUS_AQUAE
Sequence: MNFKKGEVILAPMASYTHSAFRRLCRRLGADRTYTELISAVGVLRNGIPMKLAYFTEEERPIHIQVFGSNPEEIAQASVVIAKELKPDFIDINFGCSVPKVLRNKAAGYMLQCPPLMGEVVKETVEALKPYGIPVSAKIRLGFEKDEVERIVEELQKAGVSLIAIHARTAKQGFSGKALWHRIKEAKKVASVPIIGSGDVKSWRDIERMFEETECDGVMVGRAALSNPWIFKEFKEKRDIEVGLKERMDFILEELSMMTEYMSREKACAEIKSQIVQILKGVPNSRELKTYIVHAENCKELVKRIEEAKERELLYA
What is the function of this protein?
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
What are the official names of this protein?
Probable tRNA-dihydrouridine synthase.
What is the protein family that this protein belongs to?
Belongs to the Dus family.
Protein: LIVH_ECO57
Sequence: MSEQFLYFLQQMFNGVTLGSTYALIAIGYTMVYGIIGMINFAHGEVYMIGSYVSFMIIAALMMMGIDTGWLLVAAGFVGAIVIASAYGWSIERVAYRPVRNSKRLIALISAIGMSIFLQNYVSLTEGSRDVALPSLFNGQWVVGHSENFSASITTMQAVIWIVTFLAMLALTIFIRYSRMGRACRACAEDLKMASLLGINTDRVIALTFVIGAAMAAVAGVLLGQFYGVINPYIGFMAGMKAFTAAVLGGIGSIPGAMIGGLILGIAEALSSAYLSTEYKDVVSFALLILVLLVMPTGILGRPEVEKV
What is the function of this protein?
Part of the binding-protein-dependent transport system for branched-chain amino acids.  Probably responsible for the translocation of the substrates across the membrane (By similarity).
What are the official names of this protein?
High-affinity branched-chain amino acid transport system permease protein LivH, LIV-I protein H.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYY_LIMRD
Sequence: MDILNELEWRGAINQVTDEEGLRKLTSEDKIALYCGTDPTGDSLHIGHLIPFMILKRFQLAGHHPVIIIGGGTGAIGDPSGRKSERQLQTMDQVHHNEEALTAQMKKLFGTENFTIVNNYEWLSKISLLDFLRDYGKLFNINTMLNKEVVASRLDAGISFTEFTYQILQSVDFLHLYRHNDVQLQIGGSDQWGNITAGIDLIHKVEGPDTKVYGLTIPLMLKADGTKFGKTAGGAIWLDPEKTSPYEFYQFWINQDDRDVIKYLKYFTFLSKEEIDDLAEKVEKEPWKREAQRRLAQEVTKFVHGQEAVEEAERISKALFSGDVADLSVAEIEQGFKNMPSVDVENKKENIIIWLTDNGIEPSRRQARQDVSSGAIRINGEKVDDVDAEIDPQAHFAGKFVIVRKGKKHYYLARVK
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: 468L_IIV6
Sequence: MEMATKKCNIFGVDSIGEPEGVVKKALDESLSLLDIFKFIEITNFDLDPIMTNWFWQVMVNNHSTHLGRVVLEWFGYEGEDSNQKQKFIDMLKRNKIPYKQLKHTDNEIELYPSIKEEMTLLPHKGAIASSKWLVMEPFNIKMAMLRLNTKNADIIKRYYIKMEELIRLYAQYTTLFQKREKETMSREMLDLRLMMEDMKITNHRQENMLIESHNMLRSMGVEIKDIRHENNDLLDQNNELLERVDDVLQKVNTVQKKLDISVEDRAPQPDKNTRRERFLLLKRNNDTFPYYTIRAQEINARKALKRQRNMYTDVTVLLDIVCHPNTKTFYVRIKDDLKSKGVEFNLCEINISNSNIDEAILVKEMMKINDKKRDV
What are the official names of this protein?
Putative MSV199 domain-containing protein 468L.
Protein: NEC2_HUMAN
Sequence: MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
What is the function of this protein?
Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues.  Responsible for the release of glucagon from proglucagon in pancreatic A cells.
What are the official names of this protein?
Neuroendocrine convertase 2, NEC 2, KEX2-like endoprotease 2, Prohormone convertase 2, Proprotein convertase 2, PC2.
What is the protein family that this protein belongs to?
Belongs to the peptidase S8 family. Furin subfamily.
What are the subcellular locations of this protein?
Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Localized in the secretion granules.
Protein: KTHY_BRUME
Sequence: MSGLFITFEGGEGAGKSTQIALLASHLRNHGFDPVITREPGGSPGAEAIRHVILSGNAETYGPAMEALLFAAARADHVDQLIRPTLAEGRIVLCDRFIDSSRAYQGVTGNLDATYMAAIERIAIDGAMPDLTLVLDICAERGLSRAGKRRGSDTADRFEKEDIAVHEARRQAFLEIARQEPARCKVIDADRSQEKIADEIRSVVDTILTEKGLL
What is the function of this protein?
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
What are the official names of this protein?
Thymidylate kinase, dTMP kinase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate kinase family.
Protein: RAD50_METMP
Sequence: MIIKNIKMENFRSHRNTSINFSKGITSIIGQNGSGKSSIFQAMNFALFAPRGNNFRIENLMQQGAASFSVELEFEMMGNTYLVKRKRFQHKTDDKLYVNGKLNAESASEINKKIEEILEIDNSVFSNAIYIKQGEIANLIQMTPRDRKEVIGKLLGIEKYEKASEKMNIVKKSYEETLLKLEGELTQEPEILENLEKLKNEVSESEILKEEILKKYENLEKLKLEKNSEILQMEEKFAENNQLKENLKDIISEIKNINLEIQNFKNSLNLVAEESKNISENEENYKKYLELELKIKELNNKLIGHKSNYESYNKLKTIEESLLKELGVLKESLKDNKKNPDELKENLKENDEKILILDKIKEKIKELEFIEKQIYEIKIHKKTVETLFDSVKIYDDSIKTFEELKTKKNSYENLLKEKFDLEKKLQNETDEKTKLISELTDFEKIEEKINLENELKEKYEDLSEKIDKLNEIVLKKESKISEYKNSKAELEKTKDSCHVCQSKITEEKKQELLEKYNSEIQNEQLSTESLKKQLEIILNKKEKMKVKLNEIDSFKLKYGELKEKKNYSLKVEESIIETTEKLNELTGKINEYSSLNDEISLIENKLKNLENDYKNCNYSSQFLTKNDESEFLTKKLELSKIIGDYDSSKIENEKKSLENLKDELKNTIYNLEREINLKKELKNIQNDISSKIGIVECYVKWETEKSDFENKLSECKENYEKYMESLAVLKNYSKTYSVEINNLNEFLNQKIAEKQQFCEKLLETRTEIEKNIQTVNYNPELHENAKRLYENILNEFNDILRTLERISSELKLKNENISYLNEKIQNLSNKKEEKKKIEEFKEYLDKIKREIFSKDGFQKYLREKYIPLIQRHTNQIFQEFELPYSHIQLKDDYSLIVDGLPVETLSGGEQIAVSLALRLGISKAVCNNIECIILDEPTAYLDEDRRKNLLNIFKNIKTINQMAIITHHQELEQIADNIVKVRKIGENSKVSLE
What is the function of this protein?
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair.  The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA.  Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
What are the official names of this protein?
DNA double-strand break repair Rad50 ATPase.
What is the protein family that this protein belongs to?
Belongs to the SMC family. RAD50 subfamily.
Protein: RS18_METS4
Sequence: MAFGAGGGGGRRPFFRRRKTCPFSGPNAPKIDYKDVKLLSRYVSERGKIVPSRITAVSAKKQRELAQAIKRARFLGFLPYVIR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.