Protein: PKS12_GIBZE
Sequence: MEVFVFGDQSTRFAPPLKDLLLKGNSPYLTHFVKQVHALLRREISSLPAVQQKLFPNFADIQELVSKSDWGSGNPALTSALACFYHLCSFIHFYDGQGRTFPSENSRIIGLCVGSLAAAAVSCSTSLSELVSAGVDAVRVALHVGLRVWRTTSLFDVPDRPSATWSIIVPEAVLPRESAQDRLDSFIIEMGLARSSVPYISSVAHHNMTISGPPSVLEKFIHSISTSPKDSLPVPIYAPYHASHLYSMDDVDEVLSLSAPSFASESIIPLISSSSGDELQPLKYADLLRCCVSDMLIQPLDLTKVSQAVAQLLEVSSSTRAIIKPIATSVSNSLVSALEPTLAERCAVDNSMGPKASTSHSSAETQTESSSKNSKIAIVAMSGRFPDAADLGEFWDLLYKGRDVHRQIPEDRFNAELHYDATGRRKNTSKVMNGCFIKEPGLFDARFFNMSPKEAEQSDPGQRMALETAYEALEMAGIVPDRTPSTQRDRVGVFYGMTSDDWREVNSGQNVDTYFIPGGNRAFTPGRLNYFFKFSGPSASVDTACSSSLAALHLACNSLWRNDCDTAIAGGTNVMTNPDNFAGLDRGHFLSRTGNCNTFDDGADGYCRADGVGTIILKRLEDAEADNDPILGVILGAYTNHSAEAVSITRPHAGAQEYIFSKLLRESGTDPYNVSYIEMHGTGTQAGDATEMTSVLKTFAPTSGFGGRLPHQNLHLGSVKANVGHGESASGIIALIKTLLMMEKNMIPPHCGIKTKINHHFPTDLTQRNVHIAKVPTSWTRSGQANPRIAFVNNFSAAGGNSAVLLQDAPRPSVVSDVTDPRSSHVVTMSARSADSLRKNLANLKELVEGQGDSEVDFLSKLSYTTTARRMHHQFRASVTAQTREQLLKGLDSAIERQDVKRIPAAAPSVGFVFSGQGAQYRGMGKEYFTSFTAFRSEIMSYDSIAQAQGFPSILPLIRGEVEADSLSPVEIQLGLTCLQMALAKLWKSFGVEPGFVLGHSLGHYAALHVAGVLSANDTIYLTGIRAQLLVDKCQAGTHSMLAVRASLLQIQQFLDANIHEVACVNGPREVVISGRVADIDQLVGLLSADNIKATRVKVPFAFHSAQVDPILSDLDTAASRVTFHSPQIPVLCALDSSVISPGNHGVIGPLHLQRHCRETVNFEGALHAAEREKIINKTSTLWIEIGPHVVCSTFLKSSLGPSTPTIASLRRNDDCWKVLADGLSSLYSSGLTIDWNEYHRDFKASHQVLRLPCYSWEHKNYWIQYKYDWSLTKGDPPIAPNSSVEAVSALSTPSVQKILQETSLDQVLTIVAETDLASPLLSEVAQGHRVNGVKVCTSSVYADVGLTLGKYILDNYRTDLEGYAVDVHGIEVHKPLLLKEDMNGTPQATPFRIEVRYPIQSTTALMSISTTGPNGQHIKHANCELRLEHPSQWEAEWDRQAYLINRSVNYLLQRSAQGLDSMLATGMVYKVFSSLVDYADGYKGLQEVVLHSQELEGTAKVRFQTPSGGFVCNPMWIDSCGQTTGFMMNCHQTTPNDYVYVNHGWKSMRLAKAFREDGTYRTYIRMRPIDSTKFAGDLYILDEDDTVVGVYGDITFQGLPRRVLNTVLPSANAVPVDAPMGRRDVPPSRMDVPPVRSGEGPPTSAPTQQAIALPFAADTSMDSRLRPLLRILSEEIGLGLDVLSDDELDFADHGVDSLLSLTITGRMREELGLDVESTAFMNCPTLGSFKLFLGLVDQDNKSSSGSDGSGRSSPAPGIESGATTPPMSEEDQDKIVSSHSLHQFQASSTLLQGSPSKARSTLFLLPDGSGSATSYASLPPISPDGDVAVYGLNCPWLKDASYLVEFGLKGLTELYVNEILRRKPQGPYNLGGWSAGGICAYEAALILTRAGHQVDRLILIDSPNPVGLEKLPPRLYDFLNSQNVFGSDNPHSTAGTSVKAPEWLLAHFLAFIDALDAYVAVPWDSGLVGLASPLPAPPQTYMLWAEDGVCKDSDSARPEYRDDDPREMRWLLENRTNFGPNGWEALLGGKEGLFMDRIAEANHFSMLKRGRNAEYVSAFLARALDN
What is the function of this protein?
Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:16278459, PubMed:15809006, PubMed:15780665, PubMed:16879655).  The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488).  The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881).  The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488).  Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488).  Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).
What are the official names of this protein?
Non-reducing polyketide synthase PKS12, Aurofusarin biosynthesis cluster protein PKS12.