PharMolix/UniProtQA huggingface dataset:
Protein: ANXA1_HORSE
Sequence: MSMVSAFLKQAWFIENEEQEYIKAVKGSKGGPGSAVSPYPSFNPSSDVDALHKAITVKGVDEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEALKKALTGHLEDVALALLKTPARFDADELRAAMKGLGTDEDTLIEILTSRTNKEIREINRVYREELKRDLAKDITSDTSGDFQKALLSLAKGDRSEDFGVNDDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPHLRRVFQMYTKYSKHDMNKVLDLEMKGDVENCFTAIVKCATSKPMFFAEKLHNAMKGAGTRDKILIRIMVSRSEVDMNDIKACYQKLYGISLCQAILDETKGDYEKILVALCGRD
What is the function of this protein?
Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades.  Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors.  Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration.  Promotes resolution of inflammation and wound healing.  Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
What are the official names of this protein?
Annexin A1, Annexin I, Annexin-1, Calpactin II, Calpactin-2, Lipocortin I.
What is the protein family that this protein belongs to?
Belongs to the annexin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Cell projection, cilium. Basolateral cell membrane. Lateral cell membrane. Cell membrane; Peripheral membrane protein. Apical cell membrane. Membrane; Peripheral membrane protein. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Secreted. Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted, extracellular exosome. Cytoplasmic vesicle, secretory vesicle lumen. Cell projection, phagocytic cup. Note=Colocalizes with actin fibers at phagocytic cups. Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles. Secretion is increased in response to wounding and inflammation (By similarity). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity). Detected in gelatinase granules in resting neutrophils. Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect. Displays calcium-dependent binding to phospholipid membranes (By similarity).
Protein: MCRI1_RAT
Sequence: MTSSPVSRVVYNGKRNSSPRSPTNSSEIFTPAHEENVRFIYEAWQGVERDLRSQLSSGERCLVEEYVEKVPNPSLKTFKPIDLSDLKRRNTQDAKKS
What is the function of this protein?
The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition.  Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s).  When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition.
What are the official names of this protein?
Mapk-regulated corepressor-interacting protein 1, Protein FAM195B.
What is the protein family that this protein belongs to?
Belongs to the MCRIP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, Stress granule.
Protein: FXR1_XENTR
Sequence: MEDLAVEVRGSNGAYYKGFVKDVHEDSLTVVFENNWQPERQVPFHEVRMPPLPDIKKEITEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPGNQNKSVTKSSFFKCTVDVPEDLREPCSNENVHKEFKKAVGACRVYFHAETNQLIILSACESTVKRVTILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGITAIELDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNETKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSSRGTEKEKGYATDESTASSVRGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKEELSDWSLAGEDERESRQQRDSRRRPGGRGRSGSAGRGRGGSRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHNTNRRRRSRRRRTDEDSSLMDGMTESDNASVNENGLDDSEQKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPKEPLAKGKKEKVKDVIEEHGPSEKVINGPRAASADKALKPQTTERNKASCQDGSKQEAILNGVS
What is the function of this protein?
Not involved in somite development.
What are the official names of this protein?
RNA-binding protein fxr1, XtFxr1p.
What is the protein family that this protein belongs to?
Belongs to the FMR1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Nuclear very early in embryonic development (at two hours post-fertilization), becoming cytoplasmic in later embryonic stages through to adulthood.
Protein: RL20_VIBC1
Sequence: MPRVKRGVQARARHKKVLKQAKGYYGARSRVYRVAFQAVTKAGQYAYRDRRAKKRQFRQLWIARINAASRQNGLSYSRFINGLKKASIEIDRKILADIAVFDKAAFAVLVEKAKAAL
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: GSHAB_LISMO
Sequence: MLDSFKEDPNLRKLLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDSVYEWLENLHNIVSLRSENELLWPSSNPPILPAEEDIPIAEYKTPDSPDRKYREHLAKGYGKKIQLLSGIHYNFSFPEALIDGLYANISLPEESKQDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFSKTKHEESLPDGSSALRDGISLRNSNAGYKNKEALFVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQTVESLAEHGVEYLEIRSIDLNPLEPNGISKDELDFIHLFLIKGLLSEDRELCANNQQLADENENNIALNGLAQPSIKNCDNEDIPLADAGLLELDKMSDFIKSLRPEDTKLRAIIEKQKERLLHPEKTIAAQVKQQVTKEGYVDFHLNQAKTYMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDVLDRAENFLRFQKGDHIEYVKQASKTSKDNYVSVLMMENKVVTKLVLAEHDIRVPFGDSFSDQALALEAFSLFEDKQIVVKPKSTNYGWGISIFKNKFTLEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELVEEKNTDPLRGTDHLKPLEKIRTGPEETLMLSMQNLSWDSIPKAEEIIYLRENSNVSTGGDSIDYTEEMDDYFKEIAIRATQVLDAKICGVDIIVPRETIDRDKHAIIELNFNPAMHMHCFPYQGEQKKIGDKILDFLFD
What is the function of this protein?
Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
What are the official names of this protein?
Glutathione biosynthesis bifunctional protein GshAB, Gamma-GCS-GS, GCS-GS.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
Protein: SSRP_NITOC
Sequence: MAKSKKKSSGTSSNVIALNRKARHDYFIEERYEAGLVLEGWEVKSLRAGRVQLNEGYCLLKGGEVWLFGVHLSPLNTVSTHIHPDPLRTRKLLLHAKELRKLIGAVERKGYALIPLTLYWKRGRVKLEIALAKGKQKYDKRATEKEKEWTRQKERLLKVHKFTRRGLPALAGRGIGILRKFVVFRQKSM
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: CLP1_ASPOR
Sequence: MSLPGLDLTQPSADNQFAPAPPTQVSLSKGSEWRFEVAFGTVIRVKLLAGTAELFGTELAPSQTYTFSGTKGAIYTWHGCTLEVGAGDTGPSVDGLAPGGLSGATPRGLGAGGCQSEYTAEETPMVEYANVHFALETMRQEAKATGKDGPRVLILGPENAGKTSVAKILTAYATKVERQPIVVNLDPTEGMLSVPGTLTATAFRTMMDVEEGWGSSPMSGPSAVPVKLPLVYFYPMQNPLEAEGSVYRPIVSRLALSVMGRMAEDEEARETGIIVDTPGALSQGKPGSLEMINHIVTEFSITTILVIGSERLYSLMMKNYDNKPTSSASAVASDERITVVKLSKSGGCVDRDAAFMKGVRESQIRTYFFGNPIPSTASAALSLSASSTTNVTLSPHAQQLDFNTLSIYNYTIASLEEDEDEYDPSQLGAGDSFLPGGGNDAEASQAQQDEPARATPLPGIVSSIESATPPVASNVPLKKVLPPAPSTLANSLIAITNAPTTASAAEVRDASIMGFLYVAEVDSEKGKIRALAPVGGRVPPRAIVWGKKWPGEVVGLVG
What is the function of this protein?
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
What are the official names of this protein?
mRNA cleavage and polyadenylation factor clp1.
What is the protein family that this protein belongs to?
Belongs to the Clp1 family. Clp1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PIMT_SACD2
Sequence: MDRLKLEGVGMTSKRTRDRLVERLLEQGVTSQFVLELIANTPRHLFLDEALSHRAYEDASLPIGFGQTLSQPYIVARMTEILLGAAGDPKRVLEIGTGSGYQTCILAQAVEHVWSVERIKPLQDKAKQRLRHLGLNNVTYKHADGGFGWPEQGPFDAILSAAAPRDIPKSLLQQLAHNGVLVIPVGADEQVLTLVIRDGEEDKFITQKLEPVKFVPLLSGVTR
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMAD9_MOUSE
Sequence: MHPSTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQSLCPAPPSSPGHVFPQSPCPTSYPHSPGSPSESDSPYQHSDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
What is the function of this protein?
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase.  SMAD9 is a receptor-regulated SMAD (R-SMAD).  Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4.  May play a role in osteoblast differentiation and maturation.
What are the official names of this protein?
Mothers against decapentaplegic homolog 9, MAD homolog 9, Mothers against DPP homolog 9, SMAD family member 9, SMAD 9, Smad9, Smad8.
What is the protein family that this protein belongs to?
Belongs to the dwarfin/SMAD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
Protein: RS9_XANOR
Sequence: MAITQNYGTGRRKSSTARVFLRKGTGKITVNDRPLDEFFGRETARMIVRQPLELTKNTESFDILVTASGGGTTGQAGAIRLGIARALVEYDETLKSELRKAGFMTRDAREVERKKVGLHKARRATQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: AROK_CAUVC
Sequence: MTETDQTPDTAPEAAPEVAPIVSDDLAPLRAKTIVLVGLMGVGKSSVGRRLANVLGLPFRDADNEVEAAAGRSISEIFAELGEPAFRDGERRVIARLLDEPPHVLATGGGAFVNAETRALINEKAVSVWLKADVELLARRVSRKDNRPLVRGKDPVKVLTELAEARYPAYAEAQVHVETGDTPHMVAVEAILTALRQAHA
What is the function of this protein?
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
What are the official names of this protein?
Shikimate kinase, SK.
What is the protein family that this protein belongs to?
Belongs to the shikimate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MSH2_SCHPO
Sequence: MSSRNASIANERTDEARMFNFYEKMPKDTNTVRVFDRGEFYVAIGEDASFVAQNAYHTTSVLKHHNVSNTSYCNLSPSLFIKFAEDVLSNLAKRVEIWGANSAKTGFELLKQASPGNMQMLEDLLVSENYQESTAISDSSVSSVLLAVTTRVKQDQRIIGVAFIDPILKKLGVSEFVDSDAYTNFEALIVQVGAKECIISQSGHESTNGNSAVSINTAEINRLRNIIEGCGALVTTIRSSEFSARDVELELSKVLDSPVTHALVPELGLQLAMASCNALLRYLGPALLNPDMEDDRENTSRKLHLYHHNLEQYMRLDIAAVRSLNLLPPPNGNAHKTMSLYGLLNHCRTAMGARNLRRWIVQPLLDAKSIERRHDLVSALVEDAEARQLLLDDDHLLRSIPDIPKLCRRLTRGSASLEDVVRIYQMAKALPKIVTVLDSLTSEHKDLVDKVYTNVLNNHCKNLEKLIELVETTIDLEALDSHQYIIRAEFDEELLDLRQRLDELQHSIFEEHKRVGSDLHQDTEKKLHLEQHHLYGWCLRLTRTEAGCLRGRSSHYTELSTQKNGVYFTTKRLHSLNNSYMDHQKSYRYHQNGLAREVIKIAATYGPPLEAIGQVIAHLDVILSFAHASTVAVIPYVRPNIVDSSIAQEKHGQSSNILDIVSLEDTPNFEEIRRTLENNHCARLYLKQARHPCLEAQDDVKFIPNDVNLEHGSSELLIITGPNMGGKSTYIRQVGVITVMAQIGCPVPCEVADLDIIDAILARVGASDSQLKGISTFMAEMLETATILRAATPRSLIIIDELGRGTSTTDGFGLAWAITEHIVTQIGCFCLFATHYHEMTKLSEEITTVKNLHVTAYVGDSESKDVALLYNVCEGASDRSFGIHVAKLAHFPPKIIEMASNKAAELEAEDSGAQGDTQEVKSKKEGMAIVRDIMRQWRSNVKPEMTQQQMMDQFQKVIGSFAQQINSNNWLQSRVSTNEVSS
What is the function of this protein?
Involved in post-replicative DNA-mismatch repair.  Binds to mismatch-containing DNA.  Required for correct termination of copy synthesis during mating-type switching.  Also required for proper chromosome organization during meiosis.
What are the official names of this protein?
DNA mismatch repair protein msh2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PHOP_ECO57
Sequence: MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLICRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
What is the function of this protein?
Member of the two-component regulatory system PhoQ/PhoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes.
What are the official names of this protein?
Transcriptional regulatory protein PhoP.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CRL_VIBVU
Sequence: MSEVTNNPTHNRLLAKLRAMGPYLRDPQSKEGLYYFDCLSVCIDDRKSPELREFWGWWMELEATEGGFTANYHIGKYDVEGNWLDLAIPKNALEEVNKTQNCFHLKLVKTLEENFQLSVAYHEQSVEFV
What is the function of this protein?
Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes.  Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32.
What are the official names of this protein?
Sigma factor-binding protein Crl.
What is the protein family that this protein belongs to?
Belongs to the Crl family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYW_METTH
Sequence: MIDPWGSAKLEYQDLIENFGVRPFSEVLDEVPEPSWLMRRGIIFGHRDYERIISAMKKGEDFAVVTGMMPSGRMHIGHKMIVDQLRWYDRMGAEIFIPIADMEAYSARGVDFEDSRRIAIEEYIAGYIALGLDLEKDNIHVYLQSENLMVEDLAYVLAGKVNFNELRAIYGFTGSTSMAHMYAPIIQVSDILHPQLDELGGPRPVIVPVGPDQDPHIRLTRDIAARFRDRYGFILPSSTYHRFMGGLTGGKMSSNRPKSAIFLSDTPEEAEAKIRNAKTGGRETLKEQRELGGVPEECIIYETLLYHMSGSDSRLEEIYESCRNGTLMCGECKNNTAEFIRKFFEELSVKREKALPAARRILEG
What are the official names of this protein?
Tryptophan--tRNA ligase, Tryptophanyl-tRNA synthetase, TrpRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHEB5_GEOMG
Sequence: MLPNQERKLRVLVVDDSSFMRMVIRSVLEKDPAIEVIAVAMDGVEGVEKALALRPDLITMDIEMPRLDGISALKEIMAKAPTRVLMVSTLTCEGAKATFDALDAGAIDYIPKNVTDSIDAQKAFKEELLRKVKGSGISILGRPLVSPSPRLVVPPRPVIIPRPAGQRYQYVGIGASTGGPVAVQEVLGRIPGNFPHGIVVAIHMPKAFTGPYAERLNTKCSLQVKEAKAGDIVQPGVVLVTPGGMHTALVRQGSTVAIRTIATAEYPQYIYIPSVDHMLTTFADACNGSLLGVILTGMGADGFKGMKHLKTKGGGTIVQDEATSTIYGMPRACIEGGVADTVLPLTQIGTEITKIAG
What is the function of this protein?
Involved in chemotaxis.  Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli.  Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR.  Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
What are the official names of this protein?
Protein-glutamate methylesterase/protein-glutamine glutaminase 5.
What is the protein family that this protein belongs to?
Belongs to the CheB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBG_ASHGO
Sequence: MTGEIISIQVGQCGNQVGKQFWGQLAREHGIGVDGQSLHPEDANVVREDDTNVFFRQNDHNRFTPRALLYDLEPSAIGDVQNCFPGFFNERNVWISKEELGAGNTWSIGYDYGLEKQDEFMNMIDKEIDATGNFEGFQLIHSVAGGTGSGLGSNLLEALSDRYHKKIVSTYSVFPSRESEVVVQPYNTILTLRRLIDNSDASVLFDNDALLNLTARVLRDSNTSYQQTNQLIASVMSSVTNSLRFPSYMYNSLPSIFSTLVPTPELHFLAPSFTPFTSDFVPGAKDFKRLSAYDVILDLFDKNNSMVTRDTDTPVYLAIYDALQGAVEQSDVTRAILKTQQRIKFAPWSPTSLHVNLGRKSPYNSSANSDYVSGMMLANTSSIVSVFQKTVSSFDVIFKRGAFLHKFQNGKMFQHGWDEFLESREVIQGVIDEYIAAEQENYLDDVLEEDGNFVGGDAEMIDIESNDDII
What is the function of this protein?
Tubulin is the major constituent of microtubules.  The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly (By similarity).
What are the official names of this protein?
Tubulin gamma chain, Gamma-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: RUVC_THET8
Sequence: MVVAGIDPGITHLGLGVVAVEGKGALKARLLHGEVVKTSPQEPAKERVGRIHARVLEVLHRFRPEAVAVEEQFFYRQNELAYKVGWALGAVLVAAFEAGVPVYAYGPMQVKQALAGHGHAAKEEVALMVRGILGLKEAPRPSHLADALAIALTHAFYARMGTAKPL
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair (Probable).  Endonuclease that resolves Holliday junction (HJ) intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The cleavage reactions can be uncoupled; the presence of a 5'-phosphate in a half-cut site is required for second strand cleavage (PubMed:23118486, PubMed:23980027, PubMed:31506434).  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange (PubMed:31506434).
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RECA_PARL1
Sequence: MSKNVVSLVKDDSDKKKALDAALSQIERSFGKGSIMRLGKNEQIVEIESVSTGSLGLDIALGIGGLPRGRIIEIYGPESSGKTTLALQTVAEAQKSGGVCAFVDAEHALDPIYARKLGVQLDDLLISQPDTGEQALEIADTLVRSGAVDVLVIDSVAALTPKAELEGEMGDSLPGLQARLMSQALRKLTGSISKSNTMVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGAIKDRDEVVGNQTRVKVVKNKVAPPFKQVEFDIMYGEGISKMGELVDLGSKAGIVEKSGSWFSYNSQRIGQGRENAKQFLRDNPEMAAEIEAAIRANAGLIAEKIMDVPGSERDGDEDAGDMEASA
What is the function of this protein?
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs.  It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
What are the official names of this protein?
Protein RecA, Recombinase A.
What is the protein family that this protein belongs to?
Belongs to the RecA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KAD2_XENLA
Sequence: MAPREAAPAERGSMMEGIRAILLGPPGAGKGTQAPKLAEKYCVCHLATGDMLRAMVASGSELGKRLKATMDAGKLVSDEMVVELIEKNLDTPPCKKGFLLDGFPRTVKQAEMLDELLEKRQEKLDSVIEFKVDDSLLVRRICGRLIHASSGRSYHEEFNPPKEPMKDDVTGEALIRRSDDNESTLKSRLEAYHTMTSPLVDYYQRHGIHTAVDAAQSPDVVFASILAAFSKAHCKDLVLFV
What is the function of this protein?
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP.  Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.  Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.  Plays a key role in hematopoiesis.
What are the official names of this protein?
Adenylate kinase 2, mitochondrial, AK 2, ATP-AMP transphosphorylase 2, ATP:AMP phosphotransferase, Adenylate monophosphate kinase.
What is the protein family that this protein belongs to?
Belongs to the adenylate kinase family. AK2 subfamily.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: HIS2_BACAC
Sequence: MENTFKLLFETIEERKRNPLPESYTNYLFSKGEDKILKKIGEECTEVIIASKNNDKEELVKEMVDVLYHCFVLLAEKNIPLEDIMEEVTERNGKLSRVGDRREIDTL
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COXZ_RHILW
Sequence: MSDNAPAPKKPARNNGAVVMMCLSFVFGMGAMSYAAVPLYRIFCQVTGYNGTTQRVDQVSSVVLDRTMRVTFDANVAPGLQWDFKPVEREVNPKIGETIQVHFTAENRSNETQRGQAVFNVTPGEAGVYFNKVQCFCFTETDLKPGEKLDMPVVFYIDPEIVKAVESKDIHTVTLSYTFYPKEGPKPLALNEGGAVKSEKKL
What is the function of this protein?
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
What are the official names of this protein?
Cytochrome c oxidase assembly protein CtaG.
What is the protein family that this protein belongs to?
Belongs to the COX11/CtaG family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
Protein: TRML4_MOUSE
Sequence: MAWRYSQLLLVPVQLVFLASVCCPGVWGSTVSEELHRMVGQSLSVQCQYKPKEESYVLKTWCRQTAPSKCTRVVTTSEPRKAARELQHTIWDDPEAGFFNITMTQLTEDDSAFYWCGPYYPSLREVTVLRNISLVVSPAPSTLPSQTIAPLPESTATIFMPFPVLTTSPEETTDSSINGTGHRNQSSSSPGWTSPGLLVSVQYGLLLLKALMLSVFCVLLCWRSGQGREYMAETMELSKLPHISKSLDTVSHISGYEKKANWY
What is the function of this protein?
Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages (PubMed:25848864).  Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes (PubMed:25848864).  Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production (PubMed:25848864).  Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus (PubMed:25848864).  Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs) (PubMed:22210914, PubMed:19155473, PubMed:25848864).  Does not bind nucleic acids (PubMed:25848864).  May participate in antigen presentation (PubMed:22210914).
What are the official names of this protein?
Trem-like transcript 4 protein, TLT-4, Triggering receptor expressed on myeloid cells-like protein 3, Triggering receptor expressed on myeloid cells-like protein 4.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: FPG_GEOKA
Sequence: MPELPEVETIRRTLLPLIVGKTIEDVRIFWPNIIRHPRDPEAFAARMIGQTVRGLERRGKFLKFLLDRDALISHLRMEGRYAVASALEPLEPHTHVVFCFTDGSELRYRDVRKFGTMHVYAKEEADRRPPLAELGPEPLSPAFSPAVLAERAVKTKRSVKALLLDQTVVAGFGNIYVDESLFRAGILPGRPAASLSSKEIERLHEEMVATIGEAVMKGGSTVRTYVNTQGEAGAFQHSLFVYGRKGEPCKRCGTPIEKTVVAGRGTHYCPRCQR
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.