PharMolix/UniProtQA huggingface dataset:
Protein: ATPE_PROM2
Sequence: MAISLKVLAPNKNVYQGEAEEVILPSTTGQLGILPGHISLVTAIDIGVLRLRMNSQWKSIALMGGFAEIESDEVIVLVNNAEIGSEINVQNAEQDLKEAKLAISKFSENEKNPEKIKALKQVSKAEARIQAAKN
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: DRTS_PLACH
Sequence: MEDISEIFDIYAICACCKVLNSNEKAGCFSNKTFKGLGNEGGLPWKCNSVDMKHFSSVTSYVNETNYMRLKWKRDRYMEKNNVKLNTDGIPSVDKLQNIVVMGKASWESIPSKFKPLQNRINIILSRTLKKEDLAKEYNNVIIINSVDDLFPILKCIKYYKCFIIGGASVYKEFLDRNLIKKIYFTRINNAYTCDVLFPDINEDLFKITSISDVYSSNNTTLDFVIYSKTKEIHEEINPNDELFNNTFLGVCDEKNTNFDDEDDYTYFSFNKHKDNIKKNSEHAHHFKIYNSIKYKHHPEYQYLNIIYDIIMHGNKQDDRTGVGVLSKFGYMMKFNLSEYFPLLTTKKLFVRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTDMHADYKDKGVDQLKNIINLIKNDPTCRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQPAEFIHVLGNAHVYNNHVESLKVQLNRTPYPFPTLKLNPEIKNIEDFTISDFTVQNYVHHDKISMDMAA
What is the function of this protein?
Bifunctional enzyme.  Involved in de novo dTMP biosynthesis.  Key enzyme in folate metabolism.  Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
What are the official names of this protein?
Bifunctional dihydrofolate reductase-thymidylate synthase, DHFR-TS.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the thymidylate synthase family.
Protein: PYRH_CAMJE
Sequence: MQERKRVLVKFSGEALAGENGFGIENSILKFIASEIKELIKNQIEVGIVIGGGNIIRGVSAAKGGLIKRTSGDHMGMLATVINAIAIQEALESSGLEVRVQSAIQMEAFCETYIMRRAQRHLEKGRVVVFAAGTGNPYFTTDTTAILRAVEIDADMVIKATKVNGVYDKDPKQFDDAVFLNTLSYDEAMQDNIKVMDDTAIALAKDNKLPIVVCNMFEEGNLLKIIQGDTSLCSTVKNN
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIP_RHOGL
Sequence: QDKIDPKMVQYQDSPKDGNKCSTCVNFEAPSSCKIVAGKISPNGWCIAYAPMEDKKG
What is the function of this protein?
Specific class of high-redox-potential 4Fe-4S ferredoxins.  Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.
What are the official names of this protein?
High-potential iron-sulfur protein, HiPIP.
What is the protein family that this protein belongs to?
Belongs to the high-potential iron-sulfur protein (HiPIP) family.
Protein: MNN1_CANAL
Sequence: MIQKLIKNRQRSKWVLFTGASLWIFFILDFMNSNYYNTESHISSYSIYNVYDNLHEETESPPKSALSSSLLEPSTNQQTSDFKNHLLYKSLISSLFQNTTKQTKDLNSNIYDDIFSNHKLETVLGTLSFKERCDLYFKNVFAEDVNWHFNPDTRYDMHFDKNTKEFKDFIKVKELVIQEKFDKMKEKFKEEDYNRELSKLKKSMFTDFLNEKFEQEIVNRLSTFRIFNKCYITNDETPQINKINQFITNQQKLVQDIHRDESGNFYKSKIDKLKLTNKEALVDLMVTKSSTFEHRVYPWISKEYPVYERWTGKVYHEPPNYYEILNHDPMQKTPKKIQQSNNAAQPFLKQFKNKFNGRGIVLTIGNQHSDYAVSLIHLLRALDNKLPIQIVYYDDVNEESKRKIVTAAQEDFRSLPHSFEKVAHLFGDKYINSQGKGLQPQEVWFVNAYNSIHKNYRGKFSRFGNKLLASLFNSFSEFMLIDVDTVLMQPPEYFFQLKNYQTTGTYFFKDRSVLQRRTVEDGKFFERMGPSTVDQMMFDIPIMTNYTTTRELFRGLQHYMESGLVMINKDKHLNSILMITQINLIGPITGKVWGDKELFWLGFAINGDEEYYFDDNFAAAIGELTPPQDRARKDGTWHHSKEICSPHPGHVSGDDNHSLLWINSGFRFCHQADEVNFEKEAKKKTRLKHLHTADQFRTFYYNPLRITHAVVPPLDQDLQDRKNAMDEPTSGWLWESGYCKRYMWCAYSSVGGPQKRPDEKDDTVDNNETKDNTLDGILVEYNQDEIALFNYLGDIWVGTE
What is the function of this protein?
Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose.  Implicated in late Golgi modifications (By similarity).
What are the official names of this protein?
Putative alpha-1,3-mannosyltransferase MNN1.
What is the protein family that this protein belongs to?
Belongs to the MNN1/MNT family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single- pass type II membrane protein.
Protein: HRCA_STRSV
Sequence: MVTERQNEILNLIIDIFTKTHEPVGSKALQDSINSSSATIRNDMAALEKQGLLEKAHTSSGRKPSVAGFQYFVKHSLSFDRLAENELYEVIKAFDHEFFNLEDILQQAADLLTKLSGCTVVALDVEPSRQRLTAFDIVVLSQHTALAVFTLDESNTITSQFMIPRNFLKEDLDRLKGLVRERFLGQTVLDIHYKIRTEIPQIIQRYFTTTDNVIQLFEHIFGDIFKENVILSGKVQLLEFSDLTAYQFFDDPQKVAFEIRDSLAEDQMQSVRVADSRESCLADLTLISSKFLIPYRGFGVLAVVGPVNLDYQRLVSQMNVVNRVLTMKLTDFYRYLSSNHYEVH
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: DEOC_LISMF
Sequence: MTIAKMIDHTALKPDTTKEQILTLTKEAREYGFASVCVNPTWVKLSAEQLAGAESVVCTVIGFPLGANTPEVKAFEVKDAIQNGAKEVDMVINIGALKDKDDELVERDIRAVVYAAKGKALVKVIIETCLLTDEEKVRACEIAVKAGTDFVKTSTGFSTGGATAEDIALMRKTVGPNIGVKASGGVRTKEDVEKMIEAGATRIGASAGVAIVSGEKPAKPDNY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CENPA_XENLA
Sequence: MRPGSTPPSRRKSRPPRRVSPPLPTTSRTSPRRPHAQQQRRASRASPKKRFRPGTRALMEIRKYQKSTELLIRKAPFSRLVREVCMTYACGMNYNWQSMALMALQEASEAFLVRLFEDSYLCSLHAKRVTLYVQDIQLARRIRGVNEGLG
What is the function of this protein?
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes.  Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore.  The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3.  May serve as an epigenetic mark that propagates centromere identity through replication and cell division.  Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis.
What are the official names of this protein?
Histone H3-like centromeric protein A, Centromere protein A, CENP-A.
What is the protein family that this protein belongs to?
Belongs to the histone H3 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.
Protein: ENO_PSYCK
Sequence: MYAEETNNVTAIKDIRAREILDSRGNPTIEADVILADGTIGRAAAPSGASTGSREALELRDGDQSRYMGKGVKKAVANVNSQIRSALMDKDVTAQQAIDDAMIALDGTENKDNLGANAILAVSLAVAKAAAKSQSLPLHQYIADLRNQTSLTMPVPMMNIINGGEHADNTVDIQEFMIEPVGFSSFSEALRAGTEIFHSLKSVLKSQGLNTAVGDEGGFAPNLRSNEEAITVIMQAIEQVGYTAGKDIHLALDCAATEFYKDGKYVLAGEGNKSFDSQGFSDYLVGLARQYPIISIEDGLDESDWDGWKYLTEQIGDKVQLVGDDLFVTNPAILQEGIDKKIANAILIKFNQIGTLSETLDAIYLAKKNGYATVISHRSGETEDSTIADLAVGTAAGQIKTGSLCRSDRVAKYNQLLRIEQQVRASYRGREEFIGLRG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL23_LEPBJ
Sequence: MNLQDVILTPVVTEKSQDLETIGANSKKGTRMVKYTVKVHVDANKTLIKEAFKKIFKVTPSSVNVQVYRGKIKRFRNMPAPRPHWKKAVVTFRDGASIDFAKEA
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: RS7_ACIBY
Sequence: MPRRRVVAAREILPDPKFSSQTIAKFMNHVMQDGKKSIAESIVYGALERVQEKNKVDPVEFFETTLEKVRPMVEVKARRVGGATYQVPMEVRPSRRTALAMRWLVDAAAKRSEKTMALRLAGELLDAAEGKGAAIKKREDVHRMAEANKAFSHYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: PDXA_YERPB
Sequence: MHNHNNRLVITPGEPAGVGPDLAIALAQQDWPVELVVCADPALLLARASQLNLPLQLREYQADQPAIAQQAGSLTILPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELRVALATTHLPLLAVPGAITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQQGINLIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFITALNLAIKMINNSNE
What is the function of this protein?
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
What are the official names of this protein?
4-hydroxythreonine-4-phosphate dehydrogenase, 4-(phosphohydroxy)-L-threonine dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the PdxA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SMG9_MOUSE
Sequence: MSESGHSQPGLYGIERRRRWKEPGSSGPQNLSGPGGRERDYIAPWERERRDGSEDPSTNVMQKTPIILSKPPAERSKQPPPSTAPAAPPAPAPLEKPIVLMKPREEGKGPVAGTGASTPEGTAPPPPTAPAPPKGEKEGQRPTQPVYQIQNRGMGTAAPTAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQGTGKSMVMSLLSANTPEEDQRAYVFRAQSAEMKERGGNQTSGIDFFITQERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFTDLSLYRFLQTAEMVKPSTPSPSHESSSSAGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMIDQLMAHSHLRYKGTLSMLQCNVFPGLPPDFLDAEVNLFLVPFMDSEAENENPPRAGPGSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTILTEKNWFHYAARIWDGVKKSSALAEYSRLLA
What is the function of this protein?
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.  Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity).  Plays a role in brain, heart, and eye development (PubMed:27018474).
What are the official names of this protein?
Nonsense-mediated mRNA decay factor SMG9.
What is the protein family that this protein belongs to?
Belongs to the SMG9 family.
Protein: BB13_SCHCO
Sequence: MASSVLARPGPSTVLPAMTRPPPPMAHRAAATPSFARSSQPQLTDDAVLALLANAEHTEAGEETTARGWCVVA
What is the function of this protein?
Activates B-regulated development.
What are the official names of this protein?
Mating-type pheromone BBP1(3).
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: RL20_XANOP
Sequence: MARVKRGVQARRRHKKILTLAKGYYNARRKVFRVAKQAVIKAQQYAYIGRKQKKRNFRSLWITRINAAARINGLSYSRFMNGLLKAGITLDRKVLADIAVHDAAGFTALAEKAKGALAA
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: PSRP_ECO27
Sequence: MDNAVDRHVFYISDGTAITAEVLGHAVMSQFPVTISSITLPFVENESRARAVKDQIDAIYHQTGVRPLVFYSIVLPEIRAIILQSEGFCQDIVQALVAPLQQEMKLDPTPIAHRTHGLNPNNLNKYDARIAAIDYTLAHDDGISLRNLDQAQVILLGVSRCGKTPTSLYLAMQFGIRAANYPFIADDMDNLVLPASLKPLQHKLFGLTIDPERLAAIREERRENSRYASLRQCRMEVAEVEALYRKNQIPWINSTNYSVEEIATKILDIMGLSRRMY
What is the function of this protein?
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
What are the official names of this protein?
Phosphoenolpyruvate synthase regulatory protein, PEP synthase regulatory protein, PSRP, Pyruvate, water dikinase regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Protein: NPIB7_HUMAN
Sequence: MRLRFWLLIWLLLGFISHQPTPVINSLAVYRHRETDFGVGVRDHPGQHGKTPSPQKLDNLIIIIIGFLRRYTFNVLFCTSCLCVSFLKTIFWSRNGHDGSMDVQQRAWRSNRSRQKGLRSICMHTKKRVSSFRGNKIGLKDVITLRRHVETKVRAKIRKRKVTTKINRHDKINGKRKTARKQKMFQRAQELRRRAEDYHKCKIPPSARKPLCNWVRMAAAEHCHSSGLPYWLYLTAETLKNRMGRQPPPPTQQHSITDNSLSLKTPPECLLTPLPPSVDDNIKECPLAPLPPSPLPPSVDDNLKECLFVPLPPSPLPPSVDDNLKECLFVPLPPSPLPPSVDDNLKTPPLATQEAEVEKPPKPKRWRVDEVEQSPKPKRQREAEAQQLPKPKRRRLSKLRTRHCTQAWAIRINP
What are the official names of this protein?
Nuclear pore complex-interacting protein family member B7, Nuclear pore complex-interacting protein-like 1.
What is the protein family that this protein belongs to?
Belongs to the NPIP family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP8_PAPHA
Sequence: MPQLDTSTWFTIIMAMLPTLYLITQLKLLSMNYYQPPLTKNPNLQTHNTCWRPKWTKTYLPHSQPQQS
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain.  Minor subunit located with subunit a in the membrane (By similarity).
What are the official names of this protein?
ATP synthase protein 8, A6L, F-ATPase subunit 8.
What is the protein family that this protein belongs to?
Belongs to the ATPase protein 8 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: RISB_DEIGD
Sequence: MNRIEGHLLAADLRFAIVSTRWNHLIVDRLVEGAELAFVQHGGKSENLDHFIVPGSHELPLVARRLAETGKYDAVVCLGAVIRGDTDHYKFVAGGAASGILNSALHTGVPIAFGVLTTETVEQALNRAGIKAGNKGAEATLAMIETVNLLRQIR
What is the function of this protein?
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate.  This is the penultimate step in the biosynthesis of riboflavin.
What are the official names of this protein?
6,7-dimethyl-8-ribityllumazine synthase, DMRL synthase, LS, Lumazine synthase.
What is the protein family that this protein belongs to?
Belongs to the DMRL synthase family.
Protein: PLOD3_HUMAN
Sequence: MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP
What is the function of this protein?
Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968).  Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:9582318, PubMed:9724729, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968).  Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968).  Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968).  Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660).  Essential for normal biosynthesis and secretion of type IV collagens (PubMed:18834968) (Probable).  Essential for normal formation of basement membranes (By similarity).
What are the official names of this protein?
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum. Endoplasmic reticulum lumen. Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Secreted. Secreted, extracellular space. Note=The majority of the secreted protein is associated with the extracellular matrix.
Protein: ATPG2_PHOPR
Sequence: MANAKEIRTKIASVQNTQKITSAMEMVAASKMRKVQDNMAATRPYAENMRKVISHVASGSLEYKHPYLEEREAKRVAYIIISSDRGLCGGLNSNLFKRALTDMRQWQEKNVEVDLTLIGSKAISFFHRFGNVIAQTSGLGDKPKLEDLLGAVTAMLEHFDDGKIDRLYLVYNEFVNTMVQNPRITQLLPHPDKDESQDSKPNDATSRWDYIYEPDPKDILNALMLRYIESQVYQGTVESIACEQAARMVAMKSATDNAGDIINDLQLVYNKARQSAITQELSEIVAGAQAV
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
What are the official names of this protein?
ATP synthase gamma chain 2, ATP synthase F1 sector gamma subunit 2, F-ATPase gamma subunit 2.
What is the protein family that this protein belongs to?
Belongs to the ATPase gamma chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: NPC2_BOVIN
Sequence: MRFLTVAFLFLALSASALAEPVKFKDCGSWVGVIKEVNVSPCPTQPCKLHRGQSYSVNVTFTSNTQSQSSKAVVHGIVMGIPVPFPIPESDGCKSGIRCPIEKDKTYNYVNKLPVKNEYPSIKVVVEWELTDDKNQRFFCWQIPIEVEA
What is the function of this protein?
Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:29580834, PubMed:17552909).  Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (By similarity).  May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126).  NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17573352).  Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (By similarity).  The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity).
What are the official names of this protein?
NPC intracellular cholesterol transporter 2, EPV20, Epididymal secretory protein E1, Niemann Pick type C2 protein homolog.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Lysosome. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes.
Protein: MNS1_ARATH
Sequence: MARSRSISGYGIWKYLNPAYYLRRPRRLALLFIVFVSVSMLVWDRINLAREHEVEVFKLNEEVSRLEQMLEELNGGVGNKPLKTLKDAPEDPVDKQRRQKVKEAMIHAWSSYEKYAWGKDELQPRTKDGTDSFGGLGATMVDSLDTLYIMGLDEQFQKAREWVASSLDFDKDYDASMFETTIRVVGGLLSAYDLSGDKMFLEKAKDIADRLLPAWNTPTGIPYNIINLRNGNAHNPSWAAGGDSILADSGTEQLEFIALSQRTGDPKYQQKVEKVITELNKNFPADGLLPIYINPDNANPSYSTTTFGAMGDSFYEYLLKVWVQGNKTSAVKPYRDMWEKSMKGLLSLVKKSTPSSFTYICEKNGNNLIDKMDELACFAPGMLALGASGYGPDEEKKFLSLAGELAWTCYNFYQSTPTKLAGENYFFTAGQDMSVGTSWNILRPETVESLFYLWRLTGNKTYQEWGWNIFQAFEKNSRVESGYVGLKDVNTGAKDNKMQSFFLAETLKYLYLLFSPSSVISLDEWVFNTEAHPLKIVARNDPRKPTIALRQRKFGHQINV
What is the function of this protein?
Class I alpha-mannosidase essential for early N-glycan processing.  Progressively trims alpha-1,2-linked mannose residues.  Produces Man(5)GlcNAc(2) from Man(8)GlcNAc(2), but only Man(6)GlcNAc(2) from Man(9)GlcNAc(2).  Has difficulty acting on the terminal mannose of the b-branch.  Involved in root development and cell wall biosynthesis.
What are the official names of this protein?
Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1, AtMANIb, Alpha-mannosidase IB.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 47 family.
What are the subcellular locations of this protein?
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein: G3PC_MESCR
Sequence: MAKVKVGINGFGRIGRLVARVILQRDDCELVAVNDPFISTDYMTYMFKYDSVHGQCKSHEIKLKDEKTLLFGETPVAVFGCRNPEEIPWGQAGADFVVESTGVFTDKDKAAAHLKGGAKKVVISAPSKDAPMFVVGVNEHEYKSDLNIVSNASCTTNCLAPLAKVINDRFGIVEGLMTTVHAMTATQKTVDGPSMKDWRGGRAASFNIIPSSTGAAKAVGKVLPALNGKLTGMAFRVPTCDVSVVDLTVRIEKAASYEQIKAAIKEESEGKLKGILGYTEDDLVSTDFIGDNRSSIFDAKAGISLNDNFVKLVSWYDNEWGYSTRVVDLIMHISKCQ
What is the function of this protein?
Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.  Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity).
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase, cytosolic.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.