PharMolix/UniProtQA huggingface dataset:
Protein: COBQ_PSET1
Sequence: MVQGTTSDAGKSTLVAALCRVFANRGLNVAPFKPQNMALNSAVTDDGGEIGRAQALQAIAAKVAPETDFNPILLKPNSDTGAQVIIHGKAMSNMEAGAYHDYKKVAMDAVLTSHNRLAKRFDLLLVEGAGSPAEINLRANDIANMGYAEAVDCPVIIIADIDKGGVFAHLVGTLALLSESEQARVKGFVINRFRGDISLLQSGLDWLEQYTGKPVLGVLPYLHDLALDAEDAIAIDNTLTNASVNIAVLLVPHISNHTDFDALRLHPNININYVAHTQAIPDVDLTILPGSKNVLSDLAFLKNEGWDTQIKRHLRYGGKVLGICGGMQMLGNSINDPLGVESSLQQMPGLALSDFTSTLTAQKILSNVTATMQLNNQQILCSGYEIHAGISQGEALNKPFLSFNEHPNGFTADGFISDDNAIAGTYLHGLFDQASATLQILKWLKADTVINPVNINQHREQQLERLAAMCETHLNIAHIIKIYEGHNHERTK
What is the function of this protein?
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide.  NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
What are the official names of this protein?
Cobyric acid synthase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CobQ family. CobQ subfamily.
Protein: ARGI2_HUMAN
Sequence: MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
What is the function of this protein?
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis.  Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS).  Arginine metabolism is a critical regulator of innate and adaptive immune responses.  Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970).  May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549).  May contribute to the immune evasion of H. pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity).  In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294).  Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666).  Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082).  Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324).  Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189).
What are the official names of this protein?
Arginase-2, mitochondrial, Arginase II, Kidney-type arginase, Non-hepatic arginase, Type II arginase.
What is the protein family that this protein belongs to?
Belongs to the arginase family.
Protein: RL33_BRASO
Sequence: MAKAVTIKVKLVSSADTGFYYVAKKNSRTMTEKMVKKKYDPVARKHVEFREAKIK
What are the official names of this protein?
50S ribosomal protein L33.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL33 family.
Protein: FMT_RUEST
Sequence: MRVIFMGTPEFSVPVLDALVEAGHEIAAVYCQPPRPAGRGKKDRPTPVHARAEALGLEVRHPVSLKGSEEQQAFAALNADVAVVVAYGLILPQAVLDAPRAGCLNIHASLLPRWRGAAPIHRAIMAGDTHTGICIMQMEAGLDTGPVLLRKETEIGGEETTAALHDRLSLMGARMIVDALATLPDLKAEPQPEAGVTYASKIDKAEAQIDWSVAAEEVDRKIRGLSPFPGAWFEVDGQRLKVLASRLAEGTGAVGTVLDDKLTVACGSGAVELLRLQRAGKAAQDREVFLRGFTLAKGTNLLTAQDAE
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: RL2_EDWI9
Sequence: MAIVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKTGGRNNNGRITTRHIGGGHKQQYRLIDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGERRYILAAKGLKAGDQIQSGVDAAIKAGNTLPMRNIPVGSTVHNVEMKPGKGGQLARSAGAYVQIVARDGAYVTLRLRSGEMRKIPADCRATLGEVGNAEHMLRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQTKGKKTRSNKRTDKFIVRRRSKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: DCTR_ECOLI
Sequence: MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVIIDTLMNNVFHSNFLTQIERLKPVHVIIFSPFNIKRCLGKVPVTFVPRTITIIDFVALINGSYCSVPEAAVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNLKRINELVRHQHIDYLV
What is the function of this protein?
May act as a transcriptional regulator of dctA.
What are the official names of this protein?
HTH-type transcriptional regulator DctR.
Protein: SYA_XANOM
Sequence: MNAPAKFSTSQIRSDFLAFFEGRGHTIVPSAPLVPGNDPTLLFTNSGMVQFKDVFLGAEKRSYVRAADVQRCLRAGGKHNDLDSVGYTARHHTFFEMLGNWSFGDYFKKDAIAWAWELLTQIWKLPTDRLLVTVYHTDEEAFALWRDMIGIPESRIVRIGDNKGAPYASDNFWQMADTGPCGPCTEIFFDHGDHIAGGPPGSPDEDGDRFIEIWNLVFMQFDRQPDGTLVPLPAPCVDTGMGLERLAAILQHVHTNYEIDLFQALIGKASALTGITDLENKSLRVIADHIRACSFLIVDGVLPSNEGRGYVLRRIIRRALRHGWMLGVRQPFFSKMVPTLVELMGEAYPELVVAKDTVARALLAEEERFAETLDAGMKIFDEVASRSQDIIPGADAFRLYDTYGFPVDLTADIARERGMRVDMEGFECAMERQRETARAAGKFGGGVALPADLVASMSPTVFLGYEAYDADALRVVALLKQGRPVERAQAGDEVIVFTDRTPFYAESGGQVGDSGQLNGPGVLIEVADTQKFAGQFHGHVGRISEGTLALGDVLAGGIDVQRRGKTILNHSATHLLHAALREVLGTHVQQKGSLVAPDRLRFDFSHFQPITADELAVIERKVNAEVRTNHGVEVHNMAMQEALDFGAMALFGEKYGENVRVLKMGGYSTELCGGTHVTRTGDIGLFKITSEGGVSSGVRRIEAVTGQGALDYVADEERRLLEAAHLLGGNATEVVDKVRALTERQKRLQRELESLKAKLASGATADLGAAAIDVAGVKVVAVRLEGFDAKALRDAMDRLKQQLGDSVIVLAGASGGKVALVSGVNGSPTGKVKAGELLSNIASQIGGKGGGRPDLAQGGGEDGPALATALDGVPLWVKQHLG
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: USB1_NEUCR
Sequence: MKRPLVDYDSGSGSESECGSSSDGPKSSSTNIPPQLKKRRNGDIGTRAPPSAPASTPIAPLGRSSGTHTIPPKPAPKSTSSLPPISDRFNDLYASNTRTAVSDDPSLHQGRQRQVPHIPGNWPSHVYIDWDPSSGDRELLSSLVDKLQTRVAAAAQRYPDLEGVKISTALRDPELPVDKPLHISLSAPLTLTSKNKDAFLDDVTRALRSSGVSPFVVDFSGGVNWYRSEESTRSFLVLRVREVQNTGMTTADSSPNPRLTTLLQRCNKTAKEYGQPPLYDSQDMGYRFHVTIAWTHARPSESLKQLTDSIFDDCKTMYSENMSIRDKLCTGSSFRVETVKVKIGNHVTRFELPDKGLALPVKTT
What is the function of this protein?
3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (By similarity).  Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (By similarity).
What are the official names of this protein?
U6 snRNA phosphodiesterase 1, 3'-5' RNA exonuclease USB1.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. USB1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: KDSB_SYNP6
Sequence: MVRILAVIPARYASERLPGKVLLPIAGRPMLQWVYEATIASNVFDQVAIATEDPRVVEAAAAFGAEAILTSADLASGTDRVAEASLHFPDCKVIANVQGDQPFVTPGLLQALVSPYRAGELPEMTTVGGPYDPAQDADDPNTVKVVCDQRGNALYFSRSAIPYPRTVVHDLPVYHHFGLYAFRRDFLAQYRQLPPTPLERCESLEQLRVLEQGYRIRVVPCADKVIEVNTADDLERANAWASQR
What is the function of this protein?
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
What are the official names of this protein?
3-deoxy-manno-octulosonate cytidylyltransferase, CMP-2-keto-3-deoxyoctulosonic acid synthase, CKS, CMP-KDO synthase.
What is the protein family that this protein belongs to?
Belongs to the KdsB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS3_ANAD2
Sequence: MGQKVHPIGFRLGVIRSWDSKWYEEKNYAKWLHEDIKLREFVKEKLGQAGISRIEIERAANKVKINVHTARPGIVIGKRGAGIETIKKDLQGLTDNEVYLNVVEVRKAETDAQLVAENIATQLERRIAFRRAMKKSVQTALKFGAKGIRVACSGRLGGSEMARYEWYREGRVPLHTLRADIDYGFAEAKTTYGKIGCKVWIMRGEVLPQSAAARAPRTTGGARP
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DBP5_EMENI
Sequence: MASDAPTGGSLADRISNPAETTEPVADKAQLDGAASNQGGSDLAEPEYNVEVKLSDLQADPNNPLYSVKNFEDLGLDPRILQGLSAMNFRKPSKIQERALPLLMGNPPKNLVGQSQSGTGKTAAFVLNILSRLDLSSEQAQKTPQALILAPTRELARQIVGVIQVMGKFLDGLHIGTAVPADTNARPTRMEASVVVGTPGTVMDMIKKRIMVAAKLKVIVLDEADNMLDQQGLGDQCIRVKALLPRDIQVVLFSATFPAHVHQYASKFAPAANELTLQHEELTVEGIKQLYLDCASEEDKYRTLVQLYGLLTVGSSIIFVKTRASAVEIERRMVAEGHTVASLTGGIEGSQRDQIIDQFRAGHAKVLITTNVLARGIDVSTVSMVINYDIPELHQPPNRPRQADFQTYLHRIGRTGRFGRVGVSISFVSNREEWEMLNQIQKYFNTDIQRIDTKDWDEVEDIIKKTIKNTRAQAGFR
What is the function of this protein?
ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus.  May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex.  May also be involved in early transcription (By similarity).
What are the official names of this protein?
ATP-dependent RNA helicase dbp5.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.
Protein: RECQ2_ARATH
Sequence: MESEAIQEDLQNLDVELKDVQGQISALIEHQDRLYERKSELKTLLKALAASGSPVASSGGSSAIENWSETFEWDSRADDVRFNVFGISKYRANQKEIINAIMTGRDVLVIMAAGGGKSLCYQLPAMLRGGTTLVVSPLLSLIQDQVMGLAALGISAYMLTSTSGKENEKFVYKALEKGEDDLKILYVTPEKVSKSKRFMSKLEKCHNAGRLSLISIDEAHCCSQWGHDFRPDYKNLSILKTQFPKVPMVALTATATQKVQNDLIEMLHIPKCVKFVSSVNRPNLFYSVREKSAVGKLVVDEIAEFIRESYSNNESGIVYCFSRKECEQIAGDLRERGISADYYHADMDANMREKVHMRWSKNKLQVIVGTVAFGMGINKPDVRFVIHHSLSKSMETYYQESGRAGRDGLPSECILFFRSADVPRQSSMVFYEYSGLQNLYDIVRYCQSKTKCRRSAFFRHFGEPSQDCNGMCDNCALSSEVKEVDVSDLSKLVVSMVQETQAKDQRVTMLQLGDKLRNKHKDLIAELKRDEVEHLVIKLIVDSVLKEEFQHTPYSTNAYVTMGPLANQLLQGRKTIKMETSSRQTKKLKRSITFSGLELKLDELRKEISAADGSILPHTVLSTQQIGSISSQKPVSLQELESIIGKLKTEKYGDRILEEVMRHEAVSEQLVEDPTKEETCKSRLRKRAKTQKDVVLVESSGEEEA
What is the function of this protein?
3'-5' DNA helicase that may play a role in the repair of DNA (PubMed:18419780, PubMed:19755539).  Its DNA unwinding activity in vitro is dependent on magnesium, and ATP or dATP (PubMed:18419780, PubMed:19755539).  Can use GTP/dGTP, CTP/dCTP or UTP/dUTP as nucleotide cofactors (PubMed:18419780, PubMed:19755539).  Catalyzes Holliday junction branch migration and replication fork regression (PubMed:19755539, PubMed:23771268).  Disrupts D-loop structures (PubMed:18419780).
What are the official names of this protein?
ATP-dependent DNA helicase Q-like 2, RecQ-like protein 2, AtRQ2, AtRecQ2, AtRecQl2.
What is the protein family that this protein belongs to?
Belongs to the helicase family. RecQ subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: SPRE_HUMAN
Sequence: MEGGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYDK
What is the function of this protein?
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
What are the official names of this protein?
Sepiapterin reductase, SPR.
What is the protein family that this protein belongs to?
Belongs to the sepiapterin reductase family.
Protein: THB_MOUSE
Sequence: MTPNSMTENGLPAWDKQKPRPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSPHLIQATWTSSIFHLDPDDVNDQSISSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
What is the function of this protein?
Nuclear hormone receptor that can act as a repressor or activator of transcription.  High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
What are the official names of this protein?
Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS9_ACIET
Sequence: MIGEWNNGTGRRKSSVARVFLKKGSGKITVNGKDIQQYFGRETSIMIAKQPLALTNHVETFDIQINVHGGGESGQAGAARHGITRALIDYDATLKPALSQAGFVTRDAREVERKKVGLHSARRAKQFSKR
What are the official names of this protein?
30S ribosomal protein S9.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: RS182_ROSCS
Sequence: MTFRNGGRLMRGRGGRRKVCEFSRLGILPDYKDPERLRRFLGPTGKILPRRRTGLTAKMQRRLTIAIKRARHMALLPFVERSVTDRRR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18 2.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: TBL21_ARATH
Sequence: MELPLFAILQRTPRVAITLAFVLFVLTIVPALYTLLADPILPPSISSFETDHTRLSHLNSSSNQIPSPVNGSIPTPPYHTPSKHRKSSFHRIPKPKKGPISSPTDHIPLRQRSSSFDQIPSPMNSPVPAPPHRNSSADQSPSPVNGPIPAPLNHTSLRHLNSSSDDHSSPVTTSPSRTRIRDDEQMCDLFTGEWVPNEEAPYYTNTTCWAIHEHQNCMKYGRPDTGFMRWRWKPESCDLPIFDPQEFLEMVRGKAMGFVGDSISRNQVQSLLCLLSRVEYPEDISPSPDTDFKVWNYTSYNFTLHVMWSPFLVKATKPDPKSNFFSLYLDEYDTKWTSQLDQLDYLVISSGHWFSRPVIFYENQQISGCQYCALPNTTELPLTYGYRKALRISLKAIIENFKGLAFLRSFSPQHFEGGAWNEGGDCVRTQPYRRNETIPEADLKVHDIQREEFRAAEEDGMKKSGLRLKLMDTTQAMLLRPDGHPGRYGHLQNPNVTLRNDCIHWCLPGPIDTLNDILLQMMKTDN
What is the function of this protein?
May act as a bridging protein that binds pectin and other cell wall polysaccharides.  Probably involved in maintaining esterification of pectins (By similarity).  May be involved in the specific O-acetylation of cell wall polymers (By similarity).
What are the official names of this protein?
Protein trichome birefringence-like 21.
What is the protein family that this protein belongs to?
Belongs to the PC-esterase family. TBL subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: MURD_ENTHR
Sequence: MTGNEKNFNHSKTKKVLVLGLAKSGFSAAKLLHELGALVTVNDGKPFDEKPEAQELLSLGVKVIAGSHPIELLDEEFSLMVKNPGIPYSHPFVQKAQELGIPVITEVELAYEVAECPIIGITGTNGKTTTTTMTGLLLNAGDLPGTARLAGNIGYPASSVAQEATADDKIVMELSSFQLMGITDFRPHVAVVTNIYEAHIDYHKTRKEYVKAKWHLQQNMTEKDYLILNWNQEELRELSKKTKATVLPFATEQKLPKGACSLDGSIYYNQEKIMDITELGVPGSHNVENALAAISVAKLYGISNEAIKNALHHFHGVPHRTQYVGEFQGRKFYNDSKATNILATKMALSGFQLDQLVLIAGGLDRGNSFDELIPALKGIKALITFGETQNRLEDAGKKAGIPVIKTAENAEAAVPIALELSEEGDSILLSPANASWDQYPNFEIRGERFMEAVNKLTIQK
What is the function of this protein?
Cell wall formation.  Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
What are the official names of this protein?
UDP-N-acetylmuramoylalanine--D-glutamate ligase, D-glutamic acid-adding enzyme, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUP85_MOUSE
Sequence: MEELDCEPAVTWIPGVNSKKKQMCFDWGPGEMLLCETSFNQTGKSEKVPSCPFIYIIRKDVDVYSQILRKLFNESHGIFVGLQKIEEELSGKSRKAQLVRVSKNYRSVIRACMEEMHQVAIAAKDPASGRQFSSQVSILSAMELIWNLCEILFIEVAPAGPLLLHLLDWVRLHVCEVDSLSADVLGGDNPSKHENFWDLVTVLVLQGRLDEARQMLAKEADANPSCAGMCRVLGDLMRTMPILSPGNTQTLTELELKWQHWREECERHLQDNTFAANPRLESLCKIMLGDEAALLEQKELLSNWYHFLVTRLLYSNPTVKPIDLHFYAQSSLDMFLGGESSPEPLDNILMAAFEFDIHQVIKECSIALSNWWFVAHLTDLLDHCRLLQSHNLYFGSNMREFLLLEYASGLFAHHSLWQLGVDYFDYCPELGRVSLELHIERIPLNTEQKALKVLRICEQRQMTEQVKSICKILAMKAVRNNRLGSALSWSIRAKDAAFATLVSDRFLRDYCERGCFSDLDLIDNLGSAMMLSDRLTFLGKYREFHRLYGEKRFGDAASLLLSLMTSQIAPRSFWMTLLTDALPLLEQKQVIFSAEQTYELMRCLEDLASGRPECGEPDAQRLQDDDIETTKVEMLRLALARNLARAIIREGSLEGS
What is the function of this protein?
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance.  As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus.  The Nup107-160 complex seems to be required for spindle assembly during mitosis.  NUP85 is required for membrane clustering of CCL2-activated CCR2.  Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade.  Involved in nephrogenesis.
What are the official names of this protein?
Nuclear pore complex protein Nup85, 85 kDa nucleoporin, FROUNT, Nucleoporin Nup85, Pericentrin-1.
What is the protein family that this protein belongs to?
Belongs to the nucleoporin Nup85 family.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells.
Protein: FABH_CHLPD
Sequence: MKAAITATAKYLPQSVLSNHDLEQMLETNDEWIRSRTGIGERRIMNDPSKATAYMCGEVALQLLEARKMKPEEIEVIIVATMTPDMLFPATACFVQGIIGATNAWAFDINAACSGFLFALSTASRLIESGAHKKVMVIGGDKMSSVIDYTNRSTAILFGDGAAGVILEPSTNDNYGILDARLYSDGASGTSHLLMAAGGSLNPATHETVDKRMHFLHQDGKQVFKSAVTSMADVAAEIMTRNNLSAEDISFLVPHQANQRIINATAERMGLDQEKVYSNVARYGNTTAGTIPICLAELNEQEQLKTGSNLVLVSFGAGYTWGGIYIKWQ
What is the function of this protein?
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.  Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production.  Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities.  Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
What are the official names of this protein?
Beta-ketoacyl-[acyl-carrier-protein] synthase III, Beta-ketoacyl-ACP synthase III, KAS III, 3-oxoacyl-[acyl-carrier-protein] synthase 3, 3-oxoacyl-[acyl-carrier-protein] synthase III.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. FabH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNLI2_METBF
Sequence: MTSFREFAETCQAIEKISSTIDTTSRVADLLKKVDVEELPIATHFIMSEVFPAWSGEQLGIGTSLLYVSLSKASGMPVKSIESLIRTTGDIGDTALLILKEKRKNQVTFSSFFEEQPELSITEVYNRFKIASEASGKGSQDIKIKNLQFLFTSSTPREAKYISRLALEELRIGVGEGVVRDAIAKAFSVPVDVVEHAFMVTNDLGIVAATAKDGGVEALESLGIEINRPIKMMLSQISPDIVADIKEMKEAAIEWKFDGARVQVHKAGDSVMLFSRKLENVTNSLPDLVEIIRKHVKAESAILDGEAVAVDENGRPRAFQEILKRFRRKYDVEEKALGIPIQLNLFDIMYLNGKTLIDLPLIERRKALESCVESSVEDSKSISVDKQVITGDLDLIEKIYKEALDAGHEGVMVKNPNSFYSPGKRGKNWLKKKPLMETLDLVVVGAEWGFGRRANLLGSYTVACYDPKTLRFLQVGKVGTGLTDDQLKELTEILSGLMEGGEAGGIFAIRPKIVLEIAFEEIQKSPNYDSGFALRFPRFIRIRDDKDPEEADTIQRIGKVYSQQLKRL
What is the function of this protein?
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
What are the official names of this protein?
DNA ligase 2, Polydeoxyribonucleotide synthase [ATP] 2.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent DNA ligase family.
Protein: UBP16_MACFA
Sequence: MGKKRTKGKTVPIDDSSETLEPMCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDKAEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYICDNEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENMAKENPPMNSPSQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGIVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSIPSFVDRIFGGELTSTIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTMEDEDQDSEEEKDNDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDNEYEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQEKMIESVTDNQKPTEEVDMKNINMDNDLEVLTSSPTECTRNLNGAYLTEASNGEVDISNGFKNLNLNAALHPDEINIEILNDSHTPGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANMKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL
What is the function of this protein?
Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator.  Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis.  In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes.  Regulates Hox gene expression via histone H2A deubiquitination.  Prefers nucleosomal substrates.  Does not deubiquitinate histone H2B.
What are the official names of this protein?
Ubiquitin carboxyl-terminal hydrolase 16, Deubiquitinating enzyme 16, Ubiquitin thioesterase 16, Ubiquitin-specific-processing protease 16.
What is the protein family that this protein belongs to?
Belongs to the peptidase C19 family. USP16 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: MSL9_ARATH
Sequence: MAERRVSNGEEVVINVSDKEDSKDPRASPSFNPLASPDSDAGIEKSKPVPPISIPTPEIYKFSGSVHKPPKIPSPEGLVRRKSLSRSIYSKPKSRFGEQQSFRYDSTREENGGRSLREQFGAGSFARGSFDRASPNNKSNRSVASAALSKVAEEEPDENEEIYKKVKLHRVKRSGMKPLAFLELVVFMAILGALIVSLTIDVVNKHTIWGLEFWKWCVLVMVTLSGMLVTNWFMHFVVFIIEKNYLLRKKVLYFVHGLKKNVQVFIWFSLVLIAWICLFDGDVKRTRKTKRFLDFITWTIVSLLVGSILFLVKTFALKVLASKFNVRNFFERIQESVFHQYVLQTLSGPPLIEEAENVGRVPSTGHLSFTRTKDGKVKDKKVIDMGKVHRMKQEKVSAWTMRVLIEAVGTSGISTISSTLDEVNNKKERTDKEITNEMEAVAAAYDVFNNVAKPNHNYIEEDDLLRFMIKEEVDLVLPLIEDADTGKITRKTFTEWVVNVYTSRKTIGHSLNDTKTAVKQLDKLITGILTVITFIVWMVLLDIASTKLLLVFSSQFLGLAFMIGSTCKNIFESFMFVFVMHPYDVGDRCVVDGVMLLVEEIDLLTTVFLKIDNEKVFYPNSVLISKPISNFYRSPDMGDYVDFGIAFSTPAEKIGCLKGKIGEYLVANSQHWYPEAQVMVRAIENMNKLVLNILVQHTINFQVYVEKSLRRTALIIAIKRILEDLEIDYTLLPQDVNLTGHK
What is the function of this protein?
Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer.
What are the official names of this protein?
Mechanosensitive ion channel protein 9, Mechanosensitive channel of small conductance-like 9, MscS-Like protein 9, AtMSL9.
What is the protein family that this protein belongs to?
Belongs to the MscS (TC 1.A.23) family.
Protein: AVR7_CHICK
Sequence: MVHATSPLLLLLLLSLALVAPGLSARKCSLTGEWDNNLGSNMTIGAVNDNGEFNGTYITAVADNPGNIKLSPLLGIQHKRACQPTFGFTVHWNFSESTSVFVGQCFIDRSGKEVLKTKWLQRLAVDDISDDWKATRVGYNNFTRQRTVEE
What are the official names of this protein?
Avidin-related protein 7.
What is the protein family that this protein belongs to?
Belongs to the avidin/streptavidin family.
What are the subcellular locations of this protein?
Secreted.