PharMolix/UniProtQA huggingface dataset:
Protein: HISX_STAAB
Sequence: MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVNQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIVYDVFAQAEHDELARTYVISEDAQVLKDLESRITKALPNVDRYDIVSKSIANQHYLIHASNFDDACHVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFEQIADSAQHIAHVEALYNHQQSILIRQS
What is the function of this protein?
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
What are the official names of this protein?
Histidinol dehydrogenase, HDH.
What is the protein family that this protein belongs to?
Belongs to the histidinol dehydrogenase family.
Protein: HIS6_CALS4
Sequence: MLAKRIIPCLDVKDGRVVKGINFVNLKDAGDPVEIAERYNELGADELVFLDITASYEKRKIMIDVVKRTSEKVFIPLTVGGGISDIDDIREVLKAGADKVSINTQAVKQPTLIRQAALRFGSQCVVVAIDAKKRPDGTGYNVYINGGRINTGLDAVEWAKKVKDLGAGEILLTSMDKDGTKDGYDIELTRLISEAVSIPVIASGGAGKPEHFKEVFTQGKADAALAASVFHYGELDIKELKRYLKDEGIPVRL
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU1_BUCPS
Sequence: MGEKIIIFDTTLRDGEQALQASLTTKKKLKIALSLEEMGIDIIEAGFPISSPGDFKSVETISKEFKSSIICSLARCVEKDIDIAAEAMRFAKHFRIHIFLGTSPLHVKSKLKKNFSEIIDMAIFAIKKAKRYTBDIEFSCEDAGRTPINQLCYIVENVIKAGATTINIPDTVGFTIPYEFNQIIKSLYNKVPNIDKVILSVHCHNGLGMATANSITAIQAGARQIEXTMNGMGERAGNTALEEVIIAIKLKKNNLNLHTNIKHKKIYKTRKLISEICNTVIPSNKAIIGTNAFSHSSGIHQDGILKNRKNYEIITPKSIGLKPIKLNLTSRSGRAAVKYHMTEMGYDEKLYKLDILYNSFLKLADRKGQVFDYELESLAFIDQKENTTEHFRLKKFNVQHQSTGITISSIELYCGKKIKTANTRTKKGLVNSIYITLNKITNLPIYLKNIQLITQKKPINIIISIKVQIEYKKRQFYGIGNSKDIVESTAQAMIHILNNIWKANKVNILLKNIKT
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: TRPD_VIBCH
Sequence: MQTIINKLYEQQGLTQAESQQLFDQIIRGEMDPVLMAAVLTALKIKGETPDEIAGAAKALLANANPFPRPDYDFADIVGTGGDGSNTINISTTAAFVAAACGVKVAKHGNRGVSSKSGSSDLLSSFGINLAMSAQDSRQALDDLGVAFLFAPQYHGGVRHAMPVRQTMKTRTIFNILGPLINPARPNIELMGVYSKDLVRPIAQTMLQMGLKRAAVVHGSGLDEVAIHGETQVAEIRQGELIEYTLTPEDFGVSRYPLDAIRGGEPEENRAIITQILTGNGTAAQMAAVAVNVALLLRLFGQEDLKANTQQAIAVMKSGQAYGLVQQLAQRG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: AMPA_STRCO
Sequence: MTALTLSTAAAPGLRADAIVIGVAKGAGGPSVAPGAEAVDKAYDGRLAAVLETLGASGAEGEVTKLPAPSGFKAPVVVAVGLGAEPEKDAGFDPEALRRAAGAAARALAGAKKAAFALPLAEAADAGVVAEGLLLGAYSFDAYKASAKEAKEAKGAKAKANGNGKAPLAEAALLGGKPRDKAYKAAIERATAVAEELNRARDLVNTPPNDLDPEAFAAVAQAAAKEHGIKVQVLDEKALVKGGYGGILGVGAGSASGPRLVKLSYTSPKAKKSLAFVGKGITYDSGGISLKPAGHNETMKCDMAGAAAVFAAVVAAARLGLEVNVTGWLALAENMPSGSATRPGDVLRMYSGKTVEVLNTDAEGRLVLADALWAASQDEPDAIIDVATLTGAMMLALGSRTYGIMANDDAFRSAVHEAAEESGEPAWPMPLPEHLRKGMDSPTADIANMGERMGGGLVAGLFLREFVGEGITWAHLDIAGPAFNEGGPFGYTPKGGTGTAVRTLVRVAELAAAGELG
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MATRX_MEASH
Sequence: MTEIYDFDKSAWDIKGPIAPIQPTTYSDGRLVPQVRVIDPGLGDRKDECSMYMFLLGVVEDSDPLGPPIGRAFGSLPLGVGRSTAKPEKLLKEATELDIVVRRTAGLNEKLVFYNNTPLTLLTPWRKVLTTGSVFNANQVCNAVNLIPLDTPQRFRVVYMSITRLSDNGYYTVPRRMLEFRSVNAVAFNLLVTLRIDKAIGPGKIIDNTEQLPEATFMVHIGNFRRKKSEVYSADYCKMKIEKMGLVFALGGIGGTSLHIRSTGKMSKTLHAQLGFKKTLCYPLMDINEDLNRLLWRSRCKIVRIQAVLQPSVPQEFRIYDDVIINDDQGLFKVL
What is the function of this protein?
The M protein has a crucial role in virus assembly and interacts with the RNP complex as well as with the viral membrane.
What are the official names of this protein?
Matrix protein.
What is the protein family that this protein belongs to?
Belongs to the morbillivirus/respirovirus/rubulavirus M protein family.
What are the subcellular locations of this protein?
Virion.
Protein: BGLR_PIG
Sequence: MVRGPAGAWAVLGPLLWGCGLALLQGGMLYPQESRSRERKELNGLWSFRADFSDNRRQGFEQQWYRKPLRESGPTLDMPVPSSFNDISQDGRLRSFIGWVWYEREAILPQRWTQDLGTRVVLRISSAHYYAIVWVNGVHVTEHEGGHLPFEADISKLVQTGPLSSCRITIAINNTLSPHTLPPGTILYKTDTSKYPKGYFVQNTNFDFFNYAGLHRPVLLYTTPTAYIDDITVTTDVDQDTGLVNYQIFVQGSDHFQLEVHLLDEEGRVVAKGTGGQGQLQVPSAHLWWPYLMHERPAYLYSLEVKLTAQTSAGPLSDFYTLPVGIRTVAVTERQFLINGKPFYFHGVNKHEDADIRGKGFDWSLLVKDFNLLRWLGANAFRTSHYPYAEEVMQLCDRYGIVVIDESPGVGIVLAQSFSNASLQHHLEVMEEMVRRDKNHPAVVMWSVANEPSSFLEQAAYYFKMLIGHTKALDPSRPVTFVTSSSYEKDLGVPYVDVICVNSYYSWYHDYGHMEVIQLQLATQFERWHEAYQKPIIQSEYGAETIIGFHEDPPLMFSEEYQKGLLQQYHVILDQKRKEYVVGELIWNFADFMTDQSPQRAIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYLQSAVMSQCVGNSPFTV
What is the function of this protein?
Plays an important role in the degradation of dermatan and keratan sulfates.
What are the official names of this protein?
Beta-glucuronidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 2 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: VPS28_SCHPO
Sequence: MTEYYDLNLLEKETSEENNFHTKNQQVREDLSILYSILVALEQLEKAFTKDAVSTSDFNSTCELLIQQWESCFSDERVTQAFGSFEDFCSKYRLQCPRAIKRIQEGISDERSQSNSTFSNAISTTAEPSIAMNDTTPQTVNPTKAPSNPSASIAKSIAGLVQNFITTLDAIRLNFIAKDQLHPLLSELIVSMDDLTESLKIQVSCRNKLVQWLIKINNMNITDQLNDVEKRELLYDLEQAYAECYSLL
What is the function of this protein?
Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
What are the official names of this protein?
Vacuolar protein sorting-associated protein 28 homolog, ESCRT-I complex subunit vps28.
What is the protein family that this protein belongs to?
Belongs to the VPS28 family.
What are the subcellular locations of this protein?
Endosome. Late endosome membrane; Peripheral membrane protein.
Protein: FABV_CLOPE
Sequence: MIVEPKFRGFICTTSHPIGCKKNVENQIEYVKENGKIEGAKRVLVLGASTGYGLASAIVASEACDAEVLGVSFEREAKGKRTASAGWYNIESLKKFVEGEGKKFISVNGDAFSNEVKSEVIDLIKENMGKVDLVIYSLAAPKRKDPVSGEVYSSCLKTVGAPFTSKTLDFHTGEIQNITINPATEEEIEGTRKVMGGEDWMLWIEALKEANVLENGVKTIAYSYIGPEVTYPIYREGTIGRAKNDLEKTAGEITKVLKSLNGEGYISVNKALVTQASSAIPIVSLYISILYKVMKEKGTHEGCIEQIYRMFKELYEGNLNLDSENRIRIDDLEMAEDVQKAIEEIWPQITSENVFELSDAEDFKKEFFKLFGFGLEGVDYSEDVDITTV
What is the function of this protein?
Involved in the fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
What are the official names of this protein?
Trans-2-enoyl-CoA reductase [NADH], TER.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.
Protein: RS21B_NOSS1
Sequence: MTQVVLGEHEGIDSALRRFKRQVSKAGILADVKYHRHFETPLERRKRKAVAARRKRRF
What are the official names of this protein?
30S ribosomal protein S21 B.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ALMA6_EMIHU
Sequence: MGCAGSTLRSGASFEDSRLAAIEDSRFHEVGHHAQFEDSRLAAIEDSRFHEVGHHAQFDEGGRFKQLPPANDDAKLLVADHPSLGVIRLDYDYPPALGDVDHPGSFYYDVFYRVVPGLTFELCQSGELPDDVKQRFIDAITWLDEQGVAGITGDCGFFMYFQALARSVTSKPVFMSSLCQLPAVVCAYAADEHIALFTANGESLKPMRELIKKECGVDPDDTRFVIVGCEDVPGFEAVANGDRVDVDSVLPHLVRLAEDTVAKHAGTAKPIRAILFECTELPPYSDAVRAATRLPVFDSITCCNSMLASLMDNPRFGVNNWHLSWDGAHTAHRFGDNVPPHLKGKLVNREHPENVARWNASLAERSSFSSAQQESIGRGSREL
What is the function of this protein?
Mediates cleavage of dimethylsulfonioproprionate (DMSP) into dimethyl sulfide (DMS) and acrylate.  DMS is the principal form by which sulfur is transported from oceans to the atmosphere and is a key component of the ocean sulfur cycle.
What are the official names of this protein?
Dimethylsulfonioproprionate lyase 6, DMSP lyase 6, Dimethylpropiothetin dethiomethylase 6.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family. ALMA1 subfamily.
Protein: DAPA_TOBAC
Sequence: MSSSIIGRCHFVADSIEAAGTKRRTTRWRSPRAAVIPSFHLPMRSNEVKNRTFADDIKALRLITAIKTPYLPDGRFDLEAYDTLVNLQIENGAEGVIVGGTTGEGQLMSWDEHIMLIGHTVNCFGGSIKVIGNTGSNSTREAIHATEQGFAVGMHAALHINPYYGKTSLEGLISHFESVLPMGPTIIYNVPSRTGQDIPPRVIQTMAKSPNLAGVKECVGNDRVEQYTSDGVVVWSGNDDECHVSRWDYGATGVISVTSNLVPGLMRELMFGGKNPALNSKLMPLMEWLFHEPNPIALNTALAQLGVVRPVFRLPYVPLTKAKREEFVKIVKEIGRENFIGERDVQILDDNDFILVGRY
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, chloroplastic, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: RS3_ALISL
Sequence: MGQKVHPNGIRLGIVKPWNATWFASSQEFADNLDGDFKVRQYLTKELKKASLSRIVIERPAKSIRVTIHTARPGVVIGKKGEDVEKLRAGVAKIAGVPAQINIAEVRKPELDAHLVADSIASQLERRVMFRRAMKRAVQNAMRLGAQGIKVQVGGRLGGAEIARSEWYREGRVPLHTLRADIDYATASAHTQYGVIGVKVWIFKGEVLGGMPAANAVEPKADKPKKQRRSRK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: PIMT1_NITOC
Sequence: MGMTSRRARERERLIQRLHEEGIRDPAVLKVIQETPRHIFVDEALSSRAYEDTALPIGFRQTISQPYIVARMTEALLAGGSLQKVLEVGTGSGYQTAILAGLAGLVYTVERIKPLLTQAQARFKHLGISNIRAKCADGLWGWPAYGPYQGILVAAAPREIPQTLLKQLAVGGRMVIPVGASSGTQSLMIVTRTADDFEMKTLERVSFVPLVGE
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase 1, L-isoaspartyl protein carboxyl methyltransferase 1, Protein L-isoaspartyl methyltransferase 1, Protein-beta-aspartate methyltransferase 1, PIMT 1.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FPG_HALH5
Sequence: MPELPEVETVRRTLAELVIGKTIEQVDVGWAKMIKRPDDVDQFKWLLKGQTIRSMGRRGKFLLFHLDDYTLVSHLRMEGRYGLYQQNESVAKHTHVRFVFGDGTELRYQDVRKFGTMHLFQSGREQMEPPLAKLGVEPFSDQFSAKLLTERLSKTSRKIKSALLDQGIIVGLGNIYVDEALFRARIHPERLAKDVTVAEVKILHQAILNTLTEAVNLGGSSIKSYVNGQGEMGMFQQRLDVYGRKGETCRQCGTPITKTVVGGRGTHFCSVCQK
What is the function of this protein?
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents.  Acts as DNA glycosylase that recognizes and removes damaged bases.  Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG).  Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.  Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
What are the official names of this protein?
Formamidopyrimidine-DNA glycosylase, Fapy-DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase MutM, AP lyase MutM.
What is the protein family that this protein belongs to?
Belongs to the FPG family.
Protein: DCTA_ESCF3
Sequence: MKTSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRAPDGKTHELSS
What is the function of this protein?
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
What are the official names of this protein?
C4-dicarboxylate transport protein.
What is the protein family that this protein belongs to?
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PSAI_DRIGR
Sequence: MTDLNLPSIFVPLVGLVFPAIAMASLSLHVQKNKIV
What is the function of this protein?
May help in the organization of the PsaL subunit.
What are the official names of this protein?
Photosystem I reaction center subunit VIII, PSI-I.
What is the protein family that this protein belongs to?
Belongs to the PsaI family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: URED1_BRASB
Sequence: MRSPQLSCSASEGRAVEAALSVEHAGGRSMLRRQHVGYPLHVTRGFYLDAARPDLLTLYLQSASGGLYAGDRIGLDLSVARGAAFHLTTQSATVVRDGRGRGAVQRLAVNVEAGAFCAVTSDPYVLFPGAELALASEATVADDAVLCMADGFAVHDPHARGRSFTEFSSRLRIRRPDGRLLLQDAGRISGEDLQGALGRFAAAANLVLIAPPDRLPPVKELQQAADRCGALAGASAAPNESGLVLRVLASDGGTLSCAMEAAFHVAAAGALGVALARRRK
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD 1.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DNAJ_SHEB9
Sequence: MSKRDYYEVLGVSRDTSEREIKKAYKRLAMKFHPDRNPGDKTAEANFKEIKEAYEILTDADKKAAYDQFGHAGVDPNRGGGGYGGGQGDFGDIFGDVFGDIFGGGRRGGQRQAARGSDLRYNLELSLEEAVKGLTKELRIPTLATCDLCEGSGAKKGTSATTCGTCHGQGQVQMRQGFFAVQQPCPTCHGRGKIIKDPCSKCHGDGRVEKSKTLSVKIPAGVDTGDRIRLAGEGEAGEFGAPPGDLYVQVSVREHAIFVRDGNNLYCEVPISFSKAALGGEIEVPTLDGKVSLKIPAETQTGRMFRLRGKGVKSVRSHAVGDLLCKVVMETPVNLNDRQKELLREFEATLTGESKKHSPKAEGFFDGVKKFFQDLNS
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: X_HBVC2
Sequence: MAARMCCQLDPARDVLCLRPVGAESRGRPVSGPFGPLPSPSSSAVPADHGAHLSLRGLPVCAFSSAGPCALRFTSARRMETTVNAHQVLPKVLYKRTLGLSAMSTTDLEAYFKDCLFKDWEELGEEIRLMIFVLGGCRHKLVCSPAPCNFFTSA
What is the function of this protein?
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription.  Does not seem to be essential for HBV infection.  May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma).  Most of cytosolic activities involve modulation of cytosolic calcium.  The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted.  May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential.  May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC).  Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation.  This host complex would otherwise bind to viral episomal DNA, and prevents its transcription.  Moderately stimulates transcription of many different viral and cellular transcription elements.  Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
What are the official names of this protein?
Protein X, HBx, Peptide X, pX.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus protein X family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Host mitochondrion. Note=Mainly cytoplasmic as only a fraction is detected in the nucleus. In cytoplasm, a minor fraction associates with mitochondria or proteasomes.
Protein: RS8_CUPPJ
Sequence: MSMSDPIADMLTRIRNAQGVQKASVVMPSSKLKVAIAKVLKDEGYIDDYAVQEDGGKAQLSIGLKYYAGRPVIERIERVSKPGLRVYKGRSDIPQVMNGLGVAIISTPQGLMTDRKARATGVGGEVLCYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: GARE1_DANRE
Sequence: MDLGSMLYNSFNNITWSTTTLPLDRLISSYRLPQIVKLDSGESVEGLRENDYLLIHSCRQWTTITAHSLEEGHYVIGPKIEIPVHYEGQFKLLEQDRDIKEPVQYYNSVEEVAKAFPERVYVMEEISFNFKMASGESNEDTEVYNITLSTGDELTLMGQAELLYAKSSREKSRFNTIFKRIGKLNSISKLGRGKMPCLICMNHRTNESISLPFQCRGRFSTCSQLELQMQEGEHTIRTIVEKTRLPVNVMVPSSPPRNPHDLHLIREGHRYKLVNIQTKTVVVCCALRSNKILPVHFPLHVSTALPRLLVPEGLLQGESWFETVVHRWFTYCQEQFDIDDYSRAVRDVRVDWIEDGKSPKKSSAGGTGSGSAICNSSGSGSNGCPSHLHLPSSLSSARDELTQSFHRLSVCVYGNNLHGNSEVNLQGCVSLCGDCAPAEPPDADYLFPELQENSSGSLKSDVPYEELWLDHVKNAGPVLDHNEGVRGNSLSSGCTTALPYPKAGPTSALLSADVNLPPPPVPPKSEAVKEECRLLDAPPIPPRSSKQAGSSSATVPYPSAKPRQKDTRSPSPTLSYYSSGLHSIGGEGESQIESDDQNHACYPCSWIRPDASESSKPLPCLNPSVNASFSRLSWPNDFCGADSYKGEDFQSLHCRSYSSYPRKRTPGTPKACPSGLLDFDKRANFEGKAVSSKVQQVTQSAQFCTKSTSYNMDMCRDKPTDECITKQSQSCPILPPRTPKCTDAKKDAEAATTDTADADAVELESKSCSPDGPHPGTTDVFSVSHPVATGLSWQPPSNLSGISIEEISKSLRFIGLSEDVVSLFVQEKIDGNLLLQLTEEILSEDFKLSKLQVKKLMQFINGWRPKM
What is the function of this protein?
Adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.  May promote cell proliferation (By similarity).
What are the official names of this protein?
GRB2-associated and regulator of MAPK protein 1, GRB2-associated and regulator of MAPK1.
What is the protein family that this protein belongs to?
Belongs to the GAREM family.
Protein: APOA1_CARSF
Sequence: MKAVVLTLAVLFLTGSQARHFWQQDEPQSPWDRVKDLATVYVDAIKDSGRDYVSQFEASALGKQLNLKLLDNWDSLTTSFSKLREQLGPVTQEFWDNLEKETEALRQEMNKDVEEMKTKVQPYLDEFQKKWQEEVELYRQKVEPLGSELREGARQKLQELQEKLSPLGEELRDRARTHVDSLRTQLAPYSEELRQRLASRLEALKESGGASLADYHAKASEQLSALSEKAKPALEDLRQGLLPVLESFKVSLLSALEEASKKLNAQ
What is the function of this protein?
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).  As part of the SPAP complex, activates spermatozoa motility (By similarity).
What are the official names of this protein?
Apolipoprotein A-I, Apo-AI, ApoA-I, Apolipoprotein A1.
What is the protein family that this protein belongs to?
Belongs to the apolipoprotein A1/A4/E family.
What are the subcellular locations of this protein?
Secreted.
Protein: EFP_BURPS
Sequence: MKTAQELRVGNVVMIGNDAWVVSKTEYNKSGRNAAVVKMKLKNLLNGGGQESVYKADDKFEVVVLDRKEVTYSYFADPMYVFMDADYNQYEVEAEMMGDALNYLEDGMACEVVFYNEKAISVELPTILVREITYTEPAVKGDTSSGKVLKNAKLATGFELQVPLFCNTGDKIEIDTRTNEYRSRA
What is the function of this protein?
Involved in peptide bond synthesis.  Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro.  Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
What are the official names of this protein?
Elongation factor P, EF-P.
What is the protein family that this protein belongs to?
Belongs to the elongation factor P family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK2_RHDSA
Sequence: MGIRIYRSYTPGTRNRSSSDFSEITKSKPEKSLLAKKTQKAGRNHRGVITVRHRGGGHKQRYRIVDFKRNKRDIEAKVASIQYDPNRNARIALLHYKDGEKRYILAPKNLSVGAQVSAGETAPLDVGNALPLSNIPLGTSVHNIELLPGKGGQIIRAAGTSAQIVAKEGNFVTLKLPSSEVRMVYKQCYATIGEVGNAEFKNLTLGKAGRKRWLGIRPTVRGVVMNPCDHPHGGGEGRSPIGRARPVTPWGAPALGMKTRRKNKYSDFCIIRRRK
What are the official names of this protein?
50S ribosomal protein L2, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CLPP_KORVE
Sequence: MLVPMVIEQTSRGERAYDIYSRLLRDNIIFLGTPIDDNVANLIIAQMLFLEAEDPEKDISLYINSPGGSITAGMAIYDTMQFIRPDVATICIGQCASMGATLLASGAPGKRYALPTSRILIHQPLMSGLSGQATDIDIHAREILRMREITNQLLAKHCNQRLEKVEKDVERDFIMNAQQAKEYGLVDDIIYKHK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit, Endopeptidase Clp.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUOC_RHILW
Sequence: MSEALTELASYLGEARGNLIAASQMKYGELTLTTTGENLIALLTFLRDDAKCGFVNLIDICGVDWPQRELRFDVVYHLLSPKQNVRIRVKVATDEDTPVPSACAVHPGADWFERETWDMYGVLFTGHPDLRRILTDYGFEGHPLRKDFPTTGFVEVRYDDAAKRVVYEPVELKQEFRNFDFMSPWEGTDYVLPGDEKAKQ
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit C, NADH dehydrogenase I subunit C, NDH-1 subunit C.
What is the protein family that this protein belongs to?
Belongs to the complex I 30 kDa subunit family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.