PharMolix/UniProtQA huggingface dataset:
Protein: LEUD_ACTP2
Sequence: MAGLKQHSGLVVPLDAANVDTDAIIPKQFLQAITRVGFGKHLFHEWRYLDAEETRLNPDFVLNFPQYQGATILLTRKNLGCGSSREHAPWALADYGFKVMIAPSFADIFYNNSLNNHMLPIRLSEEEVEEIFQWVWANEGKQIHIDLEAMTVTVGDKIYRFELDEFRRHCLLNGLDNIGLTLQHEDAITAYESKIPAFLR
What is the function of this protein?
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
What are the official names of this protein?
3-isopropylmalate dehydratase small subunit, Alpha-IPM isomerase, IPMI, Isopropylmalate isomerase.
What is the protein family that this protein belongs to?
Belongs to the LeuD family. LeuD type 1 subfamily.
Protein: UPPS_VIBCH
Sequence: MQNLSLSQDVLPKHIAVIMDGNGRWAKAQGKPRVFGHKNGVAAVRKTISTSARLGIKAVTLFAFSSENWRRPEEEVGVLMELFMTVLSTEIKKLHKNNLRLRVIGDKSRFSERLQTKIAQAEQLTASNTGMVVNIAANYGGQWDILQATQALAEKVTQGELQPSDIDEDVFKQHLTMADLPDVDLLIRTSGECRISNFMLWQLAYAEMYFTPVFWPEFDENCLIEAVTWFVNRERRFGCTGEQVKALMEN
What is the function of this protein?
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP).  UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
What are the official names of this protein?
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), Ditrans,polycis-undecaprenylcistransferase, Undecaprenyl diphosphate synthase, UDS, Undecaprenyl pyrophosphate synthase, UPP synthase.
What is the protein family that this protein belongs to?
Belongs to the UPP synthase family.
Protein: LPXC_ECOHS
Sequence: MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSAVLA
What is the function of this protein?
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
What are the official names of this protein?
UDP-3-O-acyl-N-acetylglucosamine deacetylase, UDP-3-O-acyl-GlcNAc deacetylase, UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.
What is the protein family that this protein belongs to?
Belongs to the LpxC family.
Protein: THIE_YERPP
Sequence: MATPGFPSTEQRLGLYPVVDSLLWIERLLAAGVTTLQLRIKNADDAQVEQDIVAAIELGKRYQARLFINDYWQLAVKHGAYGVHLGQEDLEAADLAAIQQAGLRLGISTHDEHELAVAKTLRPSYIALGHIFPTQTKQMPSSPQGLASLSRQVKNTPDYPTVAIGGISIERVPHVLATGVGSVAVVSAITLASDWQRATAQLLHLIEGKELADEK
What is the function of this protein?
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
What are the official names of this protein?
Thiamine-phosphate synthase, TP synthase, TPS, Thiamine-phosphate pyrophosphorylase, TMP pyrophosphorylase, TMP-PPase.
What is the protein family that this protein belongs to?
Belongs to the thiamine-phosphate synthase family.
Protein: MRAY_FRATH
Sequence: MLIYLFEWLSHYFKGLEVFSSYISVRIIMISITSLLITLALGRPMISWLQKMQIGQIVRDDGPQSHFSKRNTPTMGGVLILSSVIISCLLWGNLTSIYLWILILVVIFFGAIGFFDDYLKLVLKHPKGLRAKHKFALQSIFSIVLAIVLFYLLSKNGQMSLSIPFSKSLYIPMGIVIFVVLAFFIINGSSNAVNLTDGLDGLAIVPVVLVAAGLGIYAYIETNSTLANYLLFNYLGNPGLAEVAVFCAAVCGSGLAFLWFNSHPAEVFMGDVGSLTLGAVLGVIAVMVRQELIFFIMGLLFVVEALSVMLQVGSYKLRNGKRIFRMAPIHHHFELKGWPETKVVIRFWIISLILFLIGFAAIKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RL34_BACCN
Sequence: MKRTYQPNKRKRSKVHGFRSRMSTANGRKVLAARRRKGRKVLSA
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: PSBF_PROM4
Sequence: MTNSSSPLQAVEVRTYPIFTVRWLAVHALAIPTVFFLGAIAAMQFIRR
What is the function of this protein?
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Cytochrome b559 subunit beta, PSII reaction center subunit VI.
What is the protein family that this protein belongs to?
Belongs to the PsbE/PsbF family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: MORC5_ARATH
Sequence: MAESGSTNPKSPSVVPDSTLGGLKRDLRNYHDGDDSNNLSIKKSKTTKMENNCREIVPLDVTPLSIVPPDTPKLSRQFWKAGDDDEAAPVPLYCSNDAAVRVHPQFLHANATSHKWALGALAELLDNSLDEVSNGATYVHVDSTINKRDGKSSILIVEDNGGGMNPSTFRECLSLGYSRKRNMANRVGQYGNGFKTSTMRLGADAIVFSRSRGINGNNPTQSIGMLSYTFLYETRKCEAIVPTVDYELVDNKWKEIVYNSTNEWLDNLETILRWSPYLSQQDLLDQFNHLEEQGTRIVIYNLWEDDEGKMELDFDTDPHDIQLRGVNRDEKNIDMAKTYPNSRHFLTYRHSLRSYASILYLKRPDNFRIILRGEDVEHHSVLDDMMKIEEKTYKPMRSPEWPDQEEMVASLKLGFVKDAHHHIDIQGFNVYHKNRLIKPFWRVWNAAGSDGRGVIGILEANFIQPAHNKQGFERTVVLAKLESRLVTHQKNYWSSRCHEIGYAPRRKQKNYESSVTETPRPFNNINVVKGSSSSTPVPVRVFRPNVEPSGRNQIPQVETRERSFDINPEIGAKNRSYYGLGISSFKETGSVNLEAELQKVKQESAKLVSELQRQKQLLELQLQESKAKIQNLEKAQREKEVLELQLKESKARIQNLENRQEGVSTIFQQERARRDVTEDGLRKKLREASDVIDGLRKQVDTFKGKRIL
What is the function of this protein?
Exhibits ATPase activity.  Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity.  Probably involved in DNA repair.  Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing.  May also be involved in the regulation of chromatin architecture to maintain gene silencing.
What are the official names of this protein?
Protein MICRORCHIDIA 5, AtMORC5, Protein CRT1-homolog 5, CRT1-h5.
What is the protein family that this protein belongs to?
Belongs to the MORC ATPase protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PSBN_CRYJA
Sequence: METATLVAISISCLLVSFTGYALYTAFGQPSEQLRDPFEEHED
What is the function of this protein?
May play a role in photosystem I and II biogenesis.
What are the official names of this protein?
Protein PsbN.
What is the protein family that this protein belongs to?
Belongs to the PsbN family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: DCYD_SERP5
Sequence: MNLQQKLAQFPRLDLVGSATPLEKLSRLSDYLGREIYIKRDDVTPMAMGGNKLRKLEFLAADALRQGADTLVTAGAIQSNHVRQTAAVAAKLGLHCVALLENPIDTQEENYLTNGNRLLLGLFNAQVEMCEALHDPQQQLADLATRLEAQGFRPYVVPVGGSNALGALGYVQCALEIAEQSQRSNVAFSSVVVASGSAGTHAGLAVGLQQLLPETELVGVTVSRKVIDQLPKVEQIQKALANSLAIDELAPITLWDDYFAPQYGMPNEEGLAAIQLLAQQEGVLLDPVYSGKAMAGLIDGVAQQRFRDDGPILFIHTGGAPALFAYHPQV
What is the function of this protein?
Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives.  It could be a defense mechanism against D-cysteine.
What are the official names of this protein?
D-cysteine desulfhydrase.
What is the protein family that this protein belongs to?
Belongs to the ACC deaminase/D-cysteine desulfhydrase family.
Protein: ACCD_SALHS
Sequence: MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMSARNRLHSLLDEGSLVELGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLHGMPVVAAAFEFAFMGGSMGSVVGARFVRAVEQALEDNCPLVCFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIVRRPEMRLKLASILAKLMNLPAPNPDAPREGVVVPPAPDQESEA
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VL2_HPV03
Sequence: MVAHRARRRKRASATQLYRTCKAAGTCPPDVIPKVEGTTLADRILQWGSLGVYLGGLGIGTGSGTGGRTGYAPISTRPGTVVDVSVPAKPPVVIEPVGPSDPSIVNLLEDSSIINSGSTIPTFTGTDGFEVISSATTTPAVLDITPASDNVVVSSTNFSNPAFTEPSLLEVPQNGEVSGHILISTPTSGTHGYEEIPMETFASPGTGTEPISSTPVPGVSRIAGPRLYSKAVTQVKVTDPAFLTRPRSLMTFDNPVFEPEDETIIFERPYSPSQVPDSDFLDILRLHRPALTSRRGTVRYSRVGQKLSMRTRSGKGLGARVHYYQDLSPIGPTEDIEMEPLIAPASASAYDSLYDVYADVDDADIGFTSGGRSDTLSRGRATVSPLSSTLSTKYGNVTIPFVSPVDVPLQPGPDILLPASAQWPFVPLSPVDTTHYVYIDGGDFYLWPVTFFLPRRRRRKRVSYFLADGTVAL
What is the function of this protein?
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers.  Plays a role in capsid stabilization through interaction with the major capsid protein L1.  Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network.  Mechanistically, the C-terminus of L2 possesses a cell-penetrating peptide that protudes from the host endosome, interacts with host cytoplasmic retromer cargo and thereby mediates the capsid delivery to the host trans-Golgi network.  Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus.  Mediates the viral genome import into the nucleus through binding to host importins.  Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection.  Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions.  During virion assembly, encapsidates the genome by direct interaction with the viral DNA.
What are the official names of this protein?
Minor capsid protein L2.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae L2 protein family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host early endosome. Host Golgi apparatus.
Protein: ALR_LACDA
Sequence: MITAVNRPAALHINLAAIKENTRQAKAHLKPGQKLFCVVKANAYGHGAARLAPVMEEAGADGFCVAMLDEGLELRRAQIVKPILVLGLQPAEEAALAAANDISLPVSSLDWLKKAEKVLRKEGLQLKIHLAIDSGMGRIGFSEDEDFKAVNEYLQGNDAFFVEGMFTHFASADSADASYFDYQVKRFKHMESLLTVKPKWIHVDNTAAILFDKDVASDIVRFGIGLYGLNPSSAPGSRDLEPAFALKPAMSFVSELTYVKQIHKGYGVGYGSTHIAEEDEWIGTVPVGYADGWIRKFQGFKVKVGDTYCPIVGRVCMDQFMVLLPKEVPAGTPVELISADPAAPNSLRRAADWLDTIHYEVACQFNDRLDRIYDNE
What is the function of this protein?
Catalyzes the interconversion of L-alanine and D-alanine.  May also act on other amino acids.
What are the official names of this protein?
Alanine racemase.
What is the protein family that this protein belongs to?
Belongs to the alanine racemase family.
Protein: RS8_STAA2
Sequence: MTMTDPIADMLTRVRNANMVRHEKLELPASNIKKEIAEILKSEGFIKNVEYVEDDKQGVLRLFLKYGQNDERVITGLKRISKPGLRVYAKASEMPKVLNGLGIALVSTSEGVITDKEARKRNVGGEIIAYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: ERA_LYSSC
Sequence: MLETRSGYKSGFISIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTRNKVQGVLTTTDSQMIFIDTPGIHKPKHKLGDFMLKVAKNTLREVDVIMFMVNAEQKLGKGDEFILEMLAGNSTPVFLVINKIDQIHPDELLGIIESYKERYEFAEIIPISALQGNNVESLLDTLPKYLPEGPQYYPADQVTDHPERFIIYELIREKVLHLTREEIPHSIAVVIDKIRRDEENNDKIHVAATIMVERDSQKGIVIGKRGALLKEVGTRARKDIEMLLGSKVYLELWVKVQKDWRNKSTHLRDFGFRDDEY
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell membrane; Peripheral membrane protein.
Protein: FUND2_MACMU
Sequence: METSAPRAGSQVVATTERHSAACRADPLRVSSRDKLTEMAASTQGNFDGNFESLDLAEFAKKQPWWRKLFGQESGPSAEKYSVATQLFIGGVTGWCTGFIFQNVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQMPTEVRSKAEEVVSFVKKNVLVTGGFFGGFLLGMAS
What is the function of this protein?
Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (By similarity).  May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (By similarity).
What are the official names of this protein?
FUN14 domain-containing protein 2, Hepatitis C virus core-binding protein 6.
What is the protein family that this protein belongs to?
Belongs to the FUN14 family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein. Nucleus.
Protein: ATP7_YEAST
Sequence: MSLAKSAANKLDWAKVISSLRITGSTATQLSSFKKRNDEARRQLLELQSQPTEVDFSHYRSVLKNTSVIDKIESYVKQYKPVKIDASKQLQVIESFEKHAMTNAKETESLVSKELKDLQSTLDNIQSARPFDELTVDDLTKIKPEIDAKVEEMVKKGKWDVPGYKDRFGNLNVM
What is the function of this protein?
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain.  F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk.  During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.  Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
What are the official names of this protein?
ATP synthase subunit d, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the ATPase d subunit family.
What are the subcellular locations of this protein?
Mitochondrion. Mitochondrion inner membrane.
Protein: MPA53_PHAAQ
Sequence: MAVQKYTVALFLAMALVAGPAASYAADAGTPPTPATPAVPGAAAGKATTHEQKLIEDINAAFKWWPASAPPADKYKTFETAFSKANIAGASTKGLDAAYSVVYNTAAGATPEAKYDSFVTALTEALRIMAGTLEVHAVKPATEEEVPSAKILRANSRSSTRSSRFKIAATVATPLSHSTAANSAPANDKFTVFEGAFNKAIKERHGGPTETYKFIPSLEAAVKQAYGATVARAPEVKYAVFEAGLTKAITAMSEAQKVAKPVRLSPQPPQVLPLAAGGAATVAAASDSRGGYKV
What are the official names of this protein?
Major pollen allergen Pha a 5.3, Allergen Pha a 5.
What is the protein family that this protein belongs to?
Belongs to the Poa p IX/Phl p VI allergen family.
Protein: PANX1_RAT
Sequence: MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILLYLPALFWRFAAAPHLCSDLKFIMEELDKVYNRAIKAAKSARDLDLRDGPGPPGVTENVGQSLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLVTFAVVLLACIYLSYYFSLSSLSDEFLCSIKSGVLRNDSTIPDSFQCKLIAVGIFQLLSLINLLVYALLVPVVIYTLFVPFRQKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDVIDGKVPMSLQTKGEDQGSQRMDFKDLDLSSETAANNGEKNSRQRLLNSSC
What is the function of this protein?
Structural component of the gap junctions and the hemichannels.  May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity).
What are the official names of this protein?
Pannexin-1.
What is the protein family that this protein belongs to?
Belongs to the pannexin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: RR8_NASOF
Sequence: MGKDTIADIITSIRNADMNRKGTVRIGSTNITESIVKILLREGFIENVRKHRENNQYFLILTLRHRRNKKESYKTILNLKRISRPGLRIYSNSQRIPRILGGIGIVILSTSQGIMTDREARLKRIGGEILCYIW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GLO2_FRATO
Sequence: MQIKRWFLNNSLRNYQYLLYDKSHAIVIDPLKSDIFAEFIAKNKLQLEAILITHKHGDHIAGVKKLLAIYPNAKVYAYTGNDLFKPDIYVKDGSFINLGFTSFRVMYIPGHIDDHVCFLFEQERALFCGDTLFNAGVGGVQAESADINQLYDSLVKITKLDGDIKPYPAHDYWLGNLDFALSILADDSYFNYYRNQVAELAAEDKPIVNLAEEAKLNIFIRAMSDKALLKALPDYSLGREMFVKLRQLKNNF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: RS18_METSB
Sequence: MTTTAAPRRPFFRRRKTCPFSGPNAPKIDYKDTRLLSRYISERGKIVPSRITAVSAKKQRELAQAIKRARFLGLLPYVIR
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: PANB_XYLFA
Sequence: MSIYTNSKPWTVPALAEAKRNGSKIVMLTAYDAGFARILDANGVDLVLVGDSLGMVVQGHDSTLPVSVHDMVYHTACVARGVRQAMLVVDLPFQADASPERALEAATPLLRVGAQMIKIEGAGHKLEVISYLVEREIPVCSHLGLTPQSVLRFGGYKVQGRGEEAGGRLRAEARAAVEAGATLLLLECVPSQLAAQITTDVSVPTIGIGAGAGCDGQVLVLHDLLGLDSGHPRPKFVKDFLAHGGSVAGAVRAYANAVRDGSFPDVEHTYTS
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRP_PHOPR
Sequence: MAKKPNKSDNTIAKNRTARHEFAIQDDYEAGLQLQGWEVKAIRNGKVNIAESYVFLRDGEAFISGVTITPLNAASTHVVADPTRTRKLLLNRKEIDKLLGAVNREGQTIVALSMYWKASWVKLKIGTARGKKLHDKRADSKSRDWARDKQRIMKHSTR
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MP63_MYCTU
Sequence: MKLTTMIKTAVAVVAMAAIATFAAPVALAAYPITGKLGSELTMTDTVGQVVLGWKVSDLKSSTAVIPGYPVAGQVWEATATVNAIRGSVTPAVSQFNARTADGINYRVLWQAAGPDTISGATIPQGEQSTGKIYFDVTGPSPTIVAMNNGMEDLLIWEP
What are the official names of this protein?
Immunogenic protein MPT63, 16 kDa immunoprotective extracellular protein, Antigen MPT63.
What are the subcellular locations of this protein?
Secreted.
Protein: PMS1_YEAST
Sequence: MTQIHQINDIDVHRITSGQVITDLTTAVKELVDNSIDANANQIEIIFKDYGLESIECSDNGDGIDPSNYEFLALKHYTSKIAKFQDVAKVQTLGFRGEALSSLCGIAKLSVITTTSPPKADKLEYDMVGHITSKTTTSRNKGTTVLVSQLFHNLPVRQKEFSKTFKRQFTKCLTVIQGYAIINAAIKFSVWNITPKGKKNLILSTMRNSSMRKNISSVFGAGGMRGLEEVDLVLDLNPFKNRMLGKYTDDPDFLDLDYKIRVKGYISQNSFGCGRNSKDRQFIYVNKRPVEYSTLLKCCNEVYKTFNNVQFPAVFLNLELPMSLIDVNVTPDKRVILLHNERAVIDIFKTTLSDYYNRQELALPKRMCSQSEQQAQKRLKTEVFDDRSTTHESDNENYHTARSESNQSNHAHFNSTTGVIDKSNGTELTSVMDGNYTNVTDVIGSECEVSVDSSVVLDEGNSSTPTKKLPSIKTDSQNLSDLNLNNFSNPEFQNITSPDKARSLEKVVEEPVYFDIDGEKFQEKAVLSQADGLVFVDNECHEHTNDCCHQERRGSTDTEQDDEADSIYAEIEPVEINVRTPLKNSRKSISKDNYRSLSDGLTHRKFEDEILEYNLSTKNFKEISKNGKQMSSIISKRKSEAQENIIKNKDELEDFEQGEKYLTLTVSKNDFKKMEVVGQFNLGFIIVTRKVDNKYDLFIVDQHASDEKYNFETLQAVTVFKSQKLIIPQPVELSVIDELVVLDNLPVFEKNGFKLKIDEEEEFGSRVKLLSLPTSKQTLFDLGDFNELIHLIKEDGGLRRDNIRCSKIRSMFAMRACRSSIMIGKPLNKKTMTRVVHNLSELDKPWNCPHGRPTMRHLMELRDWSSFSKDYEI
What is the function of this protein?
Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis.  Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches.  This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.  Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates.
What are the official names of this protein?
DNA mismatch repair protein PMS1, Postmeiotic segregation protein 1.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutL/HexB family.
What are the subcellular locations of this protein?
Nucleus.