PharMolix/UniProtQA huggingface dataset:
Protein: ACCA_SORC5
Sequence: MAASILPFEKPVAELIEKVRELRALAAADPRFEPELAQLEDNTGRLAREIFAGLTPMQKVLLSRHANRPYTLDYIKRLFTDWVELKGDRRFADDCSIVGGLATYHGRSVVVVGHQKGRGAKENVKRNFGMPHPEGYRKAIRLYEMADRFGLPILTFIDTMGAYPGIGAEERGQSEAIGAALAAMARVGVPIVATVIGEGGSGGALALGVANRVLVLEFSCYSVISPEGCAAILWKDGSRADEAAARLKITAPDLLQLGVVDTIVEEPTGGAHQDHDDAAARLDKALWATLTSMDGLGPEELVDDRYRRFRGLGSFVG
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, ACCase subunit alpha, Acetyl-CoA carboxylase carboxyltransferase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FHI2A_BOVIN
Sequence: MFSKFTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLVILVQEENEREFGETGPCMEYLLHHKILETLYTLGKADCPPGMKQQVLVFYTKLLGKIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFLENKFKSLVSQGGPNAISEDVLKSQDSLSTDTGQSCQAEEPLGASGTEHTDLGDQPSHQMGDLSTSLENLSVTALPEATVVRPNQDYNLVNSLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLTQSTCLCELLTDRLASLYKALPQSVDPLDIETVEAVNWGLDSYSHKEDASAFPGKRALISFLSWFDYCDQLIKEAQKTAAVALAKAVHERFFIGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDILLQEMVFFILGEQREPETLAEISRHPLRHRLIEHCDHISDEISIMTLRMFEHLLQKPNEHILYNLVLRNLEERNYTEYKPVCPEDKDVVENGLIAGAVDLEEDPLFTDISPDNTLSNQEWLSSSPPATPDHPKTDGKTEVHKIVNSFLCLVPDEAKSSYHVEGTGYDTYLRDAHRQFRDYCAICLRWEWPGSPKALERCNLEAAFFEGHFLKVLFDRMGRILDQPYDVNLQVTSVLSRLSLFPHPHIHEYLLDPYVNLASGCRSLFSVIVRVVGDLMVRIQRIQDFTPKLLLVRKRLLGLEPEGPVIDHITLLEGVIVLEEFCKELAAIAFVKYHAASTP
What is the function of this protein?
May be required for proper functioning of the nervous system.
What are the official names of this protein?
FHF complex subunit HOOK interacting protein 2A, FHIP2A.
What is the protein family that this protein belongs to?
Belongs to the FHIP family.
Protein: HOA1_NOCFA
Sequence: MAYSAELDIRVTDTSLRDGSHHKRHQFTATEVRDIVAALDGAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELVTIAAQTAKQAKIAVLMLPGVGVKEDIKVSQDNGASICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHTQPPEVLAKQARIMADAGCQCVYIVDSAGALVLEQVSDRVAAVVAELGDDAQVGFHGHENLDLAVANSIYAIRAGATQIDGSARRFGAGAGNTPVEALVGVCDKLGIRTGIDFFAIADAAEDVVRPAMPQECLLDRQALMMGYAGVYSSFLKHAERQAERYGVSAAEMLVRAGRRKLVGGQEDQLIDIALELQREQQTATV
What are the official names of this protein?
4-hydroxy-2-oxovalerate aldolase 1, HOA 1, 4-hydroxy-2-keto-pentanoic acid aldolase 1, 4-hydroxy-2-oxopentanoate aldolase 1.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
Protein: TATA_MYCA1
Sequence: MGSLSPWHWAILAVVVILLFGAKKLPDAARSLGKSMRIFKSELREMQSENKTETSALGAQSESSAANPTPVQSQRVDPPAPSEQGHSEARPAS
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: BIOB_METPB
Sequence: MSDTVVSLASSQAPDAVRQDIRHDWTLAEIQAIHDMPLLDLVHRAGTVHRAHNDPADIQRAALLSIKTGGCPEDCAYCPQSAHHKGANLPRERLMPVDAVLKEAAAAKANGAHRFCMGAAWRKPKDGPEFDAVLEMVRGVRGLGMEACVTLGMLTQSQAQRLAEAGLTSYNHNLDTGPEFYGDIISTRTYDDRLQTLEHVRQAGIGVCCGGIVGMGERVRDRAEMLLVLANHAPHPESVPINALVAVEGTPLEDRPPIDPLDLVRMCATARIVMPKARVRLSAGRKSLTREAQILCFLAGANSIFYGERLLTTANNEADADAELLRDIGVPVPEVTLAAAE
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: ING3_RAT
Sequence: MLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASIKKDYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDAPSQPVNNHHAHSHTPVEKRKYNPTSHHTATDHIPEKKFKSEALLSTLTSDASKENTLGCRNNNSTASCNNAYNVNSSQPLASYNIGSLSSGAGAGAITMAAAQAVQATAQMKEGRRTSSLKASYEAFKNNDFQLGKEFSMPRETAGYSSSSALMTTLTQNASSSAADSRSGRKSKNNTKSSSQQSSSSSSSSSSSSLSLCSSSSTVVQEVSQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWFCPQCTAAMKRRGSRHK
What is the function of this protein?
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A.  This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription.  This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.  NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.  Component of a SWR1-like complex that specifically mediates the removal of histone H2A. Z/H2AZ1 from the nucleosome (By similarity).
What are the official names of this protein?
Inhibitor of growth protein 3.
What is the protein family that this protein belongs to?
Belongs to the ING family.
What are the subcellular locations of this protein?
Nucleus.
Protein: BFOB_ASPBC
Sequence: MLALYLIAGLLVGLLVYRLHLDPLSHIPGPFLAKFIPICNIRMLHTGRIVFTFRELHDTYGPVVRIGPSELSFATVTAFDSIYGFEGEKKFTIYGSRRGVVSSASGTDESLGNATSKESRRKLRPLITSTLNELMASSAEEYCHLALTEQLAAHRVGQDGSTPISLSTLNYRYLWQLANMVAFGNRGQEAHRETFNPHIRWPSPFVSFIDLLFIFCSRATIQQHARTAYKAWQAIRFVCRQTTQGPQVDFIADDSTFPDNLHRRLRQAAEKAGLDDVSDFTLLVNSMILRFSVYGTSDHMINAVFYYLLRHPQCLKRLEKEVLNAGTSVEELSDNRLAKLPYLNACINETFRISPAFNGGILQRVSCGATVDGVYVPPGVAVTVDNYTLGRSKQYWENPDAFCPERWLESSDKNVFKASRPFLIGSRQCPGRQMAYQMFRILVAKLVYLYSMELVNKDFDIERDTFCGLHWADLEVDAILKPRTDVLGY
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of bifonsecin B, a dimeric gamma-naphthopyrone (PubMed:31067027).  The first step in the biosynthesis of bifonsecin B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31067027).  YWA1 is then methylated by bfoE at position C-6 to yield foncesin which is further methylated at position C-8 by bfoD to produce fonsecin B (Probable).  A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase bfoB which catalyzes the oxidative dimerization of fonsecin B to bifonsecin B (PubMed:31067027).  Bfob also catalyzes the oxidative dimerization of rubrofusarin B into nigerone (PubMed:31067027).  The stereoselectivity of bfoB is influenced by the two natural monomeric substrates; homodimerization of fonsecin B yields a stereochemically pure biaryl, M-foncerine B, while rubrofusarin B yields a mixture of enantiomers M- and P-nigerone (PubMed:31067027).
What are the official names of this protein?
Cytochrome P450 monooxygenase bfoB, Bifonsecin B biosynthesis cluster protein B.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: ARAA_BIFAA
Sequence: MAMENPFEGKEIWFGVGSQDLYGEEALRQVAQQTGEMVDFLNATGKIPAKIVLKPTLKSSDGVKAFMTEASANPNVIGVITWCHTFSPAKMWIRGLEVLTKPLLQLATQHHKEIPWETIDMDFMNLNQAAHGDREFGYIVSRLGIPRKIVVGHYTDPEVAEKVGTWARACAGWDASQNMKVMRWGDNMRNVAVTEGDKTEAERVFGASINTWAVNDLVAAYEKVKDSQVKDLIEDYKAKYDVAPELLDSRYDELFIAAKEEAAMVNMMRENGCTAGVDNFEDLGTLPQLPGVGPQRFPSEYGWGFSAEGDWKTSVLVRIGAVMGYGLEGGASLMEDYSYNFVPGNEFDMGSHMLEVSPSIGTIAKPKLAIYPLGIGGKSDPVRLVFSGKPADAVVVSMADERERFRLLMDEVTIVEPQGSLKNLPCARAVWKPKPDLKTAVQCWITAGGSHHTCMTTSVGREAWEDFARIAGVELAVIDENTNARQFEKELELSEMYHRLNNRH
What is the function of this protein?
Catalyzes the conversion of L-arabinose to L-ribulose.
What are the official names of this protein?
L-arabinose isomerase.
What is the protein family that this protein belongs to?
Belongs to the arabinose isomerase family.
Protein: CCA_METB6
Sequence: MSGRLPFEEQLLSGQLRPSAEEREYIAGVARRLLDAINASGKATGMVVGSIARNTWVKGDRDLDVFLLFSPEMPREALETEGLALARSIARAFTPMFHEKYAEHPYINANVEGIDVDLVPCYNVASAEHIQSAVDRTPFHTRYITDKINGLTDDVLLLKQFAKAGGIYGSDQMTEGFSGYLCELLVLHYGGFAPLLAAAAEWRPPVIIDIGKHAAKKFDEPLVVIDPVDPRRNVAAAVSLDRMAEFVELARGYRDAPSEEFFRIRKEYPCCPADLAALLASRGTSLYAVTFATPPFIEEIVVPQLKRSTGAISDLLDRSGFAVHHAHYRMGPGRCMLLFELIIDELPPIRRHEGPPVWNRVNAEKFREKYRTSPLPGPFIENGRYVTEVPREFTRAGDLISSPAILSVGTGRHVRESLGKDWCVLEGADCWQEEFSGFIATFFSRRSPLVRIERDRPGRE
What is the function of this protein?
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template.  Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
What are the official names of this protein?
CCA-adding enzyme, CCA tRNA nucleotidyltransferase, tRNA CCA-pyrophosphorylase, tRNA adenylyl-/cytidylyl- transferase, tRNA nucleotidyltransferase, tRNA-NT.
What is the protein family that this protein belongs to?
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
Protein: ACCA2_BURTA
Sequence: MTNVTYLDFEKAIGELDAKIDALRCSEDESAIDLSEEINRLSARSEKLTKELYERLTPWQIVQVARHPARPYTLDYVNFIFTDFHELHGDRSYADDQSIVGGLARFNDRPCVVVGHQKGRNTKERAMRNFGYPRPEGYRKALRLFKLAEKFRLPIFTFIDTPGAWPGIDAEEHNQSEAIGRNLMEMASLQTPIITTVIGEGGSGGALAIGVGDVSIMLQFSTYSVISPESCSSILWKNPNYAEQAANALGLTAHRLKALGLIDKIANEPVGGAHRDPQQMALMLKRVLQESLRNVESLDAKQLLVRRHERLMHYGKFRETAV
What is the function of this protein?
Confers resistance to the endogenous polyketide antibiotic thailandamide.  Can replace the endogenous gene in S. typhimurium, conferring slow growth and resistance to thailandamide (PubMed:29914944).  Can also replace the endogenous gene in E. coli, conferring resistance to thailandamide (PubMed:29975047).
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha 2, ACCase subunit alpha 2, Acetyl-CoA carboxylase carboxyltransferase subunit alpha 2.
What is the protein family that this protein belongs to?
Belongs to the AccA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MFPA_CUCSA
Sequence: MGSNAKGRTVMEVGTDGVAIITIINPPVNSLSFDVLFSLRDSYEQALRRDDVKAIVVTGAKGKFSGGFDITAFGVLQGGKGEQPNVRNISIEMITDIFEAARKPAVAAIDGLALGGGLEVAMACHARISTPTAQLGLPELQLGIIPGFGGTQRLPRLVGLSKALEMMLTSKPIKGQEAHSLGLVDAIVPPEELINTARRWALEILERRRPWVHSLHRTDKLESLAEARKIFNLARAQAKKQYPNLKHTIACIDAVETGVVSGPRAGLWKEAEEFQGLLHSDTCKSLIHIFFAQRSTTKVPGVTDLGLVPRQIKKVAIVGGGLMGSGIATALILSNYHVVLKEVNDKFLQAGIDRVRANLQSRVKKGNMTNEKFEKSISLLKGVLNYESFKDVDMVIEAVIENVSLKQQIFSDLEKYCPPHCMLATNTSTIDLELIGERIKSRDRIIGAHFFSPAHIMPLLEIVRTKHTAAQVIVDLLDVGKNIKKTPVVVGNCTGFAVNRMFFPYSQAAILLAEHGVDPYQIDRAISKFGMPMGPFRLCDLVGFGVAAATASQFVQAFPERTYKSMLIPLMQEDKNAGESTRKGFYVYDKNRKAGPNPELKKYIEKARNSSGVSVDPKLTKLPEKDIVEMIFFPVVNEACRVLAEGIAVKAADLDIAGVMGMGFPSYRGGLMFWADSLGSNYIYSRLEEWSKQYGGFFKPCGYLAERAVQGATLSAPGGHAKPRM
What are the official names of this protein?
Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a.
What is the protein family that this protein belongs to?
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
What are the subcellular locations of this protein?
Glyoxysome.
Protein: RL4_CHLTR
Sequence: MVLLSKFDFSGKESGKFELPDAFFTEGKEQSVKDYLVAIQANKRQWSACTRGRSEVSHSTKKPFRQKGTGNARQGCLAAPQFRGGGIVFGPKPKFDQHIRINKKERRAAIRLLLAQKIQTGKLIVAENSVFVSSLDAPKTKEALRFLKECNVECRGVLFVDGLAHVGSNENLRLSVRNLSAVRGFTYGENISGYDIAAARNIVVSEKALELLVESLVSTTKD
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: PME51_ARATH
Sequence: MSSILILLFSLFLFSSPSSSSRHHHHHNSGDTSPVNPSSSLAAQIRLACNATRYPDQCVSSLSEQGRVPPDPKPIQIIHSAISFSFQNLKTAQSKIKSIVDSSVGNLNRTNAANTCLQLLTYSEHRTQSTDQALTRGKIKDARAWMSAALVYQYDSWSALKYVNDTSQVGETMSFLDGLIHVTSNALSMMVSYDNFGDNVASWTYPATERDGFWEKTGPGLGLDPSTGLNLGFPSGLKEDVTVCKDGKCGYKTVQDAVNAAPEDNGMRKFVIKISEGVYEENVIVPFEKKNVVFIGDGMGKTVITGSLNAGMPGITTYNTATVGVVGDGFMARDLTFQNTAGPDAHQAVAFRSDSDFSLIENCEFLGNQDTLYAHGLRQFYKNCRIQGNVDFIFGNSAAVFQDCEILIAPRQINPEKGEKNAVTAQGRIDPSQSTGFVFLNCLINGTEEYMKLFKANPKVHKNFLGRPWKDYSRTVFIGCNLEALITPDGWLPWSGDFALKTLYYGESKNTGPGSDRSQRVSWSSQIPDEHVHVYSVANFIQADEWASMSA
What is the function of this protein?
Acts in the modification of cell walls via demethylesterification of cell wall pectin.
What are the official names of this protein?
Probable pectinesterase/pectinesterase inhibitor 51.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the pectinesterase family.
What are the subcellular locations of this protein?
Secreted, cell wall.
Protein: ENO_SINMW
Sequence: MTAIIDIIGREILDSRGNPTVEVDVHLEDGSFGRAAVPSGASTGAHEAVELRDGGTRYLGKGVERAVDAVNGEIFEAIGGLDAENQIQIDRTMFELDGTPNKSRLGANAILGVSLAVAKAAAEAAGLPLYRYVGGPNAHLLPVPMMNIINGGAHADNPIDFQEFMIMPVGAETLKDAVRMGSEVFHTLKKQLAADGHNTNVGDEGGFAPGLASAPAALDFIMKSIEKAGYRPGEDMYVALDCASTEFFKDGKYVLEGEGRTLEPGAMAEYLAELAGKYPIVSIEDGMAEDDWDGWKALTDLIGNKCQLVGDDLFVTNSARLRDGIKMGVANSILVKVNQIGSLSETLDAVETAHKARYTAVMSHRSGETEDSTIADLAVATNCGQIKTGSLARSDRLAKYNQLIRIEEQLGPQAQYAGRSILRG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: RL32_UREPA
Sequence: MAVQQRRVSKSRKGMRRSHDHLTISNTVACNECGKALLPHRACRDCKTYRSIKLSIK
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: DNAK_ENTFA
Sequence: MSKIIGIDLGTTNSAVAVLEGGEAKIIANPEGNRTTPSVVSFKNGEIQVGEVAKRQAVTNPNTISSIKRHMGEAGYKVDVEGKSYTPQEVSAMILQYLKGFAEDYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGLDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLSTAGDNNLGGDDFDNKIIDYMVAEFKKENGIDLANDKMALQRLKDAAEKAKKDLSGVTSTQISLPFITAGEAGPLHLEMNLTRAKFDELTSDLVERTKVPVRQALKDAGLNPSEIDEVILVGGSTRIPAVVEAVRKETNKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGVPQIEVSFDIDKNGIVNVRAKDLGTQKEQTITIKSSSGLSDDEIERMVKDAEANAEADKQRKEEVDLRNDADALLFTVDKTLKELEGKVDAEEVKKAEDARDELKAAIEANDIEQMKAKRDSLNEIVQNLTVKLYEQAAQQQAQENPEAAQGGADDVVDADFEEVNGDDK
What is the function of this protein?
Acts as a chaperone.
What are the official names of this protein?
Chaperone protein DnaK, HSP70, Heat shock 70 kDa protein, Heat shock protein 70.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: ROT21_LITRO
Sequence: AGGLDDLLEPVLNSADNLVHGL
What is the function of this protein?
Lacks antimicrobial activity.  Does not inhibit the formation of NO by neuronal nitric oxide.
What are the official names of this protein?
Rothein 2.1.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Rothein subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RLMN_HELPH
Sequence: MKASIYDFTLDELSQLLKPSFRAKQLYLWLYAKYKTSFKDMQNNFSKDFIAYLEREFTLRTIEITHVRKSVDGSKKYLFKSLRDNHTFEAVLLKMKDKKIDEKTNAILEGEKYTVCVSCQIGCQVGCSFCFTQKGGFVRNLKASEIIQQALLIKEDNNLPIEKALNIVFMGMGEPLNNLDEVCKAIEIFNTGMQISPRRITVSTSGVADKIPILAGKNLGVQLAISLHAVDDKTRSSLMPLNKKYNIECVLNEVRKWPLEQRKRVMFEYLLIKDLNDSLDCAKKLLKLLNGIKSKVNLILFNPHEGSKFERPSLESARMFADFLNSKGLLCTIRESKALDIEAACGQLREKKLSQQI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RT17_BOVIN
Sequence: MSVVRSSVHAKWIVGKVIGTAMQKTAKVRVTRLVLDPYLLKYFNKRKTYFAHDALQQCTVGDIVLLKALPVPRTKHVKHELAEIVFKVGQVVDPVTGKRCAGTTYLESPVDLETTPLAKNLEELSLSTTQ
What are the official names of this protein?
28S ribosomal protein S17, mitochondrial, MRP-S17, S17mt.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: APTX_CANLF
Sequence: MMRMCWLVRQDNQHQRIKLPHLEAVMVGRGPETKIIDKKCSRQQVQLKAECNKGYVKVKQVGVNPTSIDSVIIGKDQEAKLQPGQVLHMVNELYPYIVEFEEEAESPGLETHRKRKRSGNSDSIERDAAQEAESSTGLEPGSDSSQCSVPLNKGKDAPTKKESLGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWASVSSLKAVTGEHLELLKHMHTVGEKMIADFAGSSKLRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQHAGRVSVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRRHWPK
What is the function of this protein?
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair.  Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species.  Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined.  Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity).  Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).
What are the official names of this protein?
Aprataxin, Forkhead-associated domain histidine triad-like protein, FHA-HIT.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization (By similarity).
Protein: MTNA_ANADF
Sequence: MNPQPLRPVIYDEGRDVVRVLDQRRLPSEEVWLDLASCDEVVQAIKDLTVRGAPAIGVAAAYGLALESRRGAEPARLREASERLVHARPTAVNLAWAVRRMSRRLGLGPAALLEEAHAIRDEDEAACRRIGALGAALLPPRASVLTHCNAGALATAGYGTALGVVRAAVEGGNPVTVFADETRPFLQGARLTAWELKRDGIPVTLLTDNMAGWLMAQGEIACVVVGADRIAANGDVANKIGTYALAVLAAYHHLPFYVAAPWSTVDLATPDGSAIPIEERGDEEVVTLAGQRIAPAGVPARYPAFDVTPEPLVTAIITERGVVRRPFAPGLAALAAR
What is the function of this protein?
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
What are the official names of this protein?
Methylthioribose-1-phosphate isomerase, M1Pi, MTR-1-P isomerase, S-methyl-5-thioribose-1-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Protein: CBLB_XENTR
Sequence: MASSSSSSSSTNSSAVTGRLPGARSANPRKARILGLFDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQERRNLTKLSLIFSHMLAEIKAIFPSGQFQGDNFRITKADAAEFWRKFFGERTIVPWKIFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWTSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTDLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESDGQGCPFCRCEIKGTEPIVVDPFDPRDENRCCSFNDSLCTPMLDFDDDDLREECLIMNRLASLRKMNERQNSPVTSPGSSPLSQRRKTPPDPLQIPHLNLPPVPPRLDLIQKGLARSPCASPTGSPKSSPCMVRKQDKPLPAPPPPLREPPPPPERPPPIPPDSRTCRHLHHTENVPCRDQSTQHDAWCTRDISGASQPSICRVAHDGSPKLGVPSSSVLNGRHSRMSTEAGFIRHKHHKRRESPLETIRVYNGLSGNEEYDVPPRLSPPPPPPTITIHPAIKCPLLVNSVSDKVRNSAEEDDSEYKIPSSHPVSSRLPLHCHSIKHFPRLCENGQCLSNGTHNGISEIKKLKQPDQGDVIATSTVPVPLPSARTSARENHPHGSSLTRTPSDYDLLVPHPGEESFDSSPPSQPPPPPPARTCVPEHAMPTASGCRPNSDVDLFLPHSDPCPEAPLPPARRGPGEAKSNRLSQEYDQLPSCPDCPQAPARPPKPVPRRTAPEIHHRRHYNCDSLAENVDAKIAKLMGEGFPFEEVKRALEIAQNNVDVARSILREFAFPPPVCPRLHL
What is the function of this protein?
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
What are the official names of this protein?
E3 ubiquitin-protein ligase CBL-B, RING-type E3 ubiquitin transferase CBL-B, SH3-binding protein CBL-B, Signal transduction protein CBL-B.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR10_MESCR
Sequence: MATSSLSTIVFSPLALSNSSSFPNKPQVSNLSLHSSLSNLRRTLSHSSPSSSSSSNVRVFAAPEVLESQETGPESYVEEGSETSALGIGADSDQMAPKQKIRIKLRSYWVPLIEDSCKQIMDAARTTNAKTMGPVPLPTKKRIFCVLKSPHVHKDARFHFEIRTHQRLIDILYPTAQTIDSLMQLDLPAGVDVEVKL
What are the official names of this protein?
30S ribosomal protein S10, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: GASP3_MOUSE
Sequence: MTGSKNKARAQAKLEKRASAQARAVAEREAANANRGAGKSRDKGKGKAGSKSDAVAEVKAGSKGKVVAETKEGARPESKALVKGTSDFNHRTENKFARSTRKDKPSSDNWFWAGEDSGINSWFWKGEELSNNSVAKCENKPSTSIQARAEEPAPRTSHKSRSGAEEEEEENVIGNWFWEGDDTGFDTDPKPVFKIVKPQPVDEINEKDRPKDWSEVTIWPKAPAVTPAVLGYRSQDSSEARSSSYIVLASNEEETSTACTKNTRSSLQSIPEYPFGSDPCIQTLDEIRQQIKIREENGIKPFACPCKLECYLDSPEFEKLVNILKSTTDPLIHKIAQIAMGIHKVHPFAQEFINEVGVVTLIESLLSFSSPEVSIKKAVITLNSSGDDRYNKVEFHVKHMCKETVSFPLNSPGQQSGLKIIGQLTTESVHHYIVVSYFSELFHLLSQGNRKTRNLVLKVFLNMSENPKAARDMINMKALAALKLIFNQKEAKANLVSAVAIFINIKEHIRKGSIVVVDHLSYNTLTAIFREVKGIIERM
What is the function of this protein?
Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis.  Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP.
What are the official names of this protein?
G protein-coupled receptor associated sorting protein 3, Protein BHLHb9, bHLHb9.
What is the protein family that this protein belongs to?
Belongs to the GPRASP family.
Protein: OPSB_ANOCA
Sequence: MNGTEGINFYVPLSNKTGLVRSPFEYPQYYLAEPWKYKVVCCYIFFLIFTGLPINILTLLVTFKHKKLRQPLNYILVNLAVADLFMACFGFTVTFYTAWNGYFIFGPIGCAIEGFFATLGGQVALWSLVVLAIERYIVVCKPMGNFRFSATHALMGISFTWFMSFSCAAPPLLGWSRYIPEGMQCSCGPDYYTLNPDYHNESYVLYMFGVHFVIPVVVIFFSYGRLICKVREAAAQQQESASTQKAEREVTRMVILMVLGFLLAWTPYAMVAFWIFTNKGVDFSATLMSVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTICCGKNPFGDEDVSSSVSQSKTEVSSVSSSQVSPA
What is the function of this protein?
Visual pigments are the light-absorbing molecules that mediate vision.  They consist of an apoprotein, opsin, covalently linked to cis-retinal.  This opsin uses a vitamin A2 chromophore.
What are the official names of this protein?
Blue-sensitive opsin, Blue photoreceptor pigment, RH2 opsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.