PharMolix/UniProtQA huggingface dataset:
Protein: RS171_BACTN
Sequence: MISLMEARNLRKERTGVVLSNKMEKTITVAAKFKEKHPIYGKFVSKTKKYHAHDEKNECNIGDTVRIMETRPLSKTKRWRLVEIIERAK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17 1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: URED_ACTP2
Sequence: MQSKLLLSTKLTSQGKTQLDQYFVSPPFKVMTLPAYDDAWQNGLNAMQMSSSPGLLAGDLLDIEISLADNTALSLNTQAFTRVQSMNEGDYATQKTCIKLGKNSRLFYLPHPLVLHKDSGFKQTTEIEMSEQSELIYGEIVAIGRVLNGERFAFRHFASYLRISYQNQPLVTDRIQWLPAKMALTSLSQMEDFSHQGSLTYVNLAKNAVEIKAMVSELQALAAEQKNMLIGVSQLNEGGLMVRVLAHRADIIQHLFERIGQVLKAQSNIV
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NDHI_SYNS9
Sequence: MFGFLKQVGDYTRDAVDAARNLAQGFAVTFDHMQRRPVTVQYPYEKLIPSERYRGRIHYEFDKCIACEVCVRVCPINLPVVDWVMNKATKKKELRNYSIDFGVCIFCGNCVEYCPTNCLSMTEEYELAAFDRHSLNYDNVALGRLPTSVTTDPSVQPLRELVYLPAGEMDPHTVSADRPRAGKLPAEVLETLAPVKDEGQSSKAVLKEDA
What is the function of this protein?
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain.  The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone.  Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NAD(P)H-quinone oxidoreductase subunit I, NAD(P)H dehydrogenase I subunit I, NDH-1 subunit I, NDH-I.
What is the protein family that this protein belongs to?
Belongs to the complex I 23 kDa subunit family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Peripheral membrane protein.
Protein: HPRK_XANC8
Sequence: MNTSITARELFDQQRDKLALRWVAGQKGEHREIQAGSNNARRPSLAGYLNVIYPNKVQILGTEELAWLDSLDARQRWETIEKIIQVQPLALAISKNQSCPEDLRAAADESNTPLWISPKRGHELLNHLSYHLARTLAPRVTLHGVFMEIYSIGVLITGEAGSGKSELALELLSRGHRLVADDAPEFTQIAPDVLDGTCPELLQDLLEVRGLGVLNVRDMFGDTAVKKNKYLRLIVHLTRPMTEPTPSGYERLTGDSGSRHVLDLDVPLITLPVMPGRNLAVLTEAATRLHILRTKGIDPAAMFIARHSNLLERRTP
What is the function of this protein?
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS).  HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
What are the official names of this protein?
HPr kinase/phosphorylase, HPrK/P, HPr(Ser) kinase/phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the HPrK/P family.
Protein: UBIA_ACIET
Sequence: MSAVAPRSRLSLYLDLIRWNRPAGWLVLVWPTLAALWVAADGFPGWHLLAVFVAGTVLMRSAGCTINDIADRDFDRHVKRTTQRPITSGQLGVREAALVGVVLTLVAFVLVLTTRWEAVAWSVPAVLFTILYPFTKRFFAMPQAFLGIAFNFGIVIAFAAVQGRVPATAWVLWLANLFLVLAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAAIMGFFVLCLGLTAWVLAPYGLGWPLWLGLGVAAAQVAWHFTLIKDRTREGCFTAFSKSHWIGAAIFAGVALGYLLR
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ATPF_ORYNI
Sequence: MKNVTHSFVFLAHWPSAGSFGLNTDILATNLINLTVVVGVLIYFGKGVLKDLLDNRKQRILSTIRNSEELRRGTIEQLEKARIRLQKVELEADEYRMNGYSEIEREKANLINATSISLEQLEKSKNETLYFEKQRAMNQVRQRVFQQAVQGALGTLNSCLNTELHFRTIRANISILGAMEWKS
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, chloroplastic, ATP synthase F(0) sector subunit b, ATPase subunit I.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MURB_ANAMM
Sequence: MSYGFVAYNLPKVQGTYRRGVKMHNATWFNVGGVAEVVFKPSSVEDLAAFVRDTNLPISVVGVASNLIVRDGIVKGVVVKLGREFSYINCNGNIITAGCATLLSNLAVAAQESGISGLEFFVGIPGTVGGAIEMNAGAYGGDVASVLRSVRAVNEHGEICTLSNDDMRYSYREHGLVGKWIFVDATFVGACGDRDAIKGTMREFIARRNDSQPVRGRTGGSTFKNPEGHQAWELIDKAGCRGLQIGGAQVSEKHCNFLLNCGGATAKDLEDLGNEIRCRVHSMFGIKLEWEIRFLGCGL
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylenolpyruvoylglucosamine reductase, UDP-N-acetylmuramate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the MurB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROC_ECO45
Sequence: MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLEIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQKIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: KMCP1_MACFA
Sequence: MSALNWKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALYSGIAPAMLRQSSYGTIKIGTYQSLKRLFVERPEDETLLINVICGILSGVISSTIANPTDVLKIRMQAQSSTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLQDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIILFVTYEQLKKLDL
What is the function of this protein?
Probable transporter.
What are the official names of this protein?
Kidney mitochondrial carrier protein 1, Solute carrier family 25 member 30.
What is the protein family that this protein belongs to?
Belongs to the mitochondrial carrier (TC 2.A.29) family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: T23O_HUMAN
Sequence: MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
What is the function of this protein?
Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine.  Catalyzes the oxidative cleavage of the indole moiety.
What are the official names of this protein?
Tryptophan 2,3-dioxygenase, TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase.
What is the protein family that this protein belongs to?
Belongs to the tryptophan 2,3-dioxygenase family.
Protein: SYI_BACSU
Sequence: MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERTKDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIETALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEYEAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDGKGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASACGFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDFIIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHSYPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFTHPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSVDYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLIKLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSMQTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEKFDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVSELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEIVEKYYQK
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RP35_RABPU
Sequence: MQHPREENSIVVELEPSLATFIKQGFNNLVKWPLLNIGIVLSNTSTAVNEEWLTAVEHIPTMKIFYKHIHKILTREMGFLVYLKRSQSERDNYITLYDFDYYIIDKDTNSVTMVDKPTELKETLLHVFQEYRLKSSQTIELIAFSSGTVINEDIVSKLTFLDVEVFNREYNNVKTIIDPDFVSRSPFIVISPMGKLTFFVEVYSWFDFKSCFKDIIDFLEGALIANIHNHMIKVGDCDETVSSYNPESGMLFVNDLMTMNIVNFFGCNSRLESYHRFDMTKVDVELFIKALSDACKKILSASNRL
What is the function of this protein?
Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates.  Responsible for the transcription of early, intermediate and late genes.  DNA-dependent RNA polymerase associates with the early transcription factor (ETF) thereby allowing the early genes transcription.  Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase 35 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the poxviridae DNA-directed RNA polymerase 35 kDa subunit family.
What are the subcellular locations of this protein?
Virion. Note=All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome. This is necessary because viral early mRNAs are synthesized within minutes after virus entry into the cell and are extruded through pores in the core particle (By similarity).
Protein: FLIT_DICCH
Sequence: MENLSPLLIEYQGLLKLIRNIKAMALNGLWDDVVEQEIVYIQSIERISQINVPANIPSTVQLQFRQLLQDILDTESQVKELLQNRMQELAVLIQQSQNQKSINNTYAEFSDDILPGKPQP
What is the function of this protein?
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD.  As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons.  As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
What are the official names of this protein?
Flagellar protein FliT.
What is the protein family that this protein belongs to?
Belongs to the FliT family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: YPT1_SCHPO
Sequence: MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTFELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDVTDQDSFNNVKQWLQEIDRYAVEGVNRLLVGNKSDMVDKKVVEYSVAKEFADSLNIPFLETSAKDSTNVEQAFLTMSRQIKERMGNNTFASSNAKSSVKVGQGTNVSQSSSNCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.  Ypt1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi.  Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.  Also involved in the recycling of membrane proteins.
What are the official names of this protein?
GTP-binding protein ypt1.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side.
Protein: DEOC_LACLM
Sequence: MQINKYIDHTILKADAPKSKVQQIIDEAKKYDFMSVCINPTWVNYASQELKDSDVKVCTVIGFPLGANTSELKAFEAKNAIENGADEIDMVINIGAAKSKDWDLVESDIADVNAVKGDKLLKVIIETSLLTDEEKIKACQIAKAVGADFVKTSTGFSTGGAAVHDVKLMRQTVGPDMGVKASGGVHNLEEAKAMIDAGATRLGVSAGVAIMEGLTSNDSY
What is the function of this protein?
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
What are the official names of this protein?
Deoxyribose-phosphate aldolase, DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase.
What is the protein family that this protein belongs to?
Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: THPR_GEOSE
Sequence: MKRSHYFIAVPLTSEAKQAISRFSGDASSSLPFRTWVHEEDYHITLAFLGDVPPGKMAPLCEAMAAVAAKSAPFSLALAGLGTFGERTAPRIFWQGVKEEAALNELRRDVYEACLSLGFSLDRRPFAPHITIARKWQGEAPFQPEALRSLPAASTVFSVPEIVLYRTNMEKTPKYETIAAFPLLGAPDGRTGEGMGQLLKLRDYISRYETDVYHYVPEFIRLKQWQWEQAKARWEAERDADGARREPGETWDFLLDKPSWWERLIGRWRRGPEPEMDEERSPAPSLSRAATLDELKWQFLDDLFELQGMPAGRL
What is the function of this protein?
Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
What are the official names of this protein?
RNA 2',3'-cyclic phosphodiesterase, RNA 2',3'-CPDase.
What is the protein family that this protein belongs to?
Belongs to the 2H phosphoesterase superfamily. ThpR family.
Protein: PDXH_BAUCH
Sequence: MNKQSINIAQIRREYTHKRLRRADLTLEPMELFERWFRQASTAQLLDLTVVSVATVDQTGQPYQRLVLLKHFDAKGMVFYTNLGSRKAQHLAHNARISLHFPWHALERQVMVLGTAKQLALKEVMHYFSSRPRNSQISAWASSQSSLIDTRDTLVSTFLKFNNYFHQGKVPLPSFWGGYRVHIDSMEFWQGGAYRLHDRFIYQRIASGWRIDRLAP
What is the function of this protein?
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
What are the official names of this protein?
Pyridoxine/pyridoxamine 5'-phosphate oxidase, PNP/PMP oxidase, PNPOx, Pyridoxal 5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Protein: CIAO1_MONBE
Sequence: MACSCLLMASMQTLPGPGAFRTENGTLYLAFQEYYEAPQDPHNMADALSQTLSNSSLSQTLLSQTLISHTFLSQTLLSNSSLSHSLTLSQNSQTLLSQTLLSQTLLSLLSLTLSHSLKTLSNSFFSLKLFSLKLLDVFSLSHTRTSTREDGGDGQDGHEDRVWDVKWSPTGAVLASSSGDQTVRLWTREARDWVCLSTLEGPQKGTIRSLSWGREGNYLAAASFDSTTCVWEKGPSGFECFATLEGHENEVKGVAFSASGDYIATWFADEEEFDCAAILAEHSQDVKAVAWHPTRDLLASCSYDNTIRFYRADPDNADWICCDTLSDNQSTVWKICFNADGSRLAAVGDDRTLRVYQAFPPGNPQGAALPAHSSIYAPCLRNTLHSAINRLVCSDFAGIVTPSASDDKWKCIATITGQHTRPIYSVDWDPETNILATAGGDNIVRLFRETAVQPDTNTPSYELIGQFQAHDQDLNGLAWAPNQPDLQHRLLATCADDGLHVGNHKS
What is the function of this protein?
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery.  Required for the maturation of extramitochondrial Fe/S proteins.
What are the official names of this protein?
Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CIA1 family.
Protein: CDII_DICD3
Sequence: MLAWNNLVEMLGCSKASNEFIYLPQKLNELPVFEEGVLGDRSYYSFFNSGVLFLLEDDLVNQISLYIQADEGFSAYTGELPLPVNSRESEIIQVLGTPSGSGGGKMDMLLGYVNRWIKYKTESHTLHIQFDQNDQLCRVTLMQ
What is the function of this protein?
Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system.  CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion.  Protects cells against the DNase activity of CdiA, its cognate toxin protein, but not against non-cognate CdiA from E. coli strain 536 / UPEC.
What are the official names of this protein?
Immunity protein CdiI.
Protein: CDH1_YEAST
Sequence: MSTNLNPFMNNTPSSSPLKGSESKRVSKRPISSSSSASLLSSPSRRSRPSTVYGDRYIPSRTDIDFNSIVSISSMASVPALNPSSTEDQVEYQKERQAHETYNTLLKNELFGEMLSKDTVGSESSIDRIKNTRPSTRGNVHAENTTRHGYELERVSTPPPEAAGLEEFSPHSTPVTPRRLFTSQQDEITRPSSNSVRGASLLTYQQRKGRRLSAASLLQSQFFDSMSPVRPDSKQLLLSPGKQFRQIAKVPYRVLDAPSLADDFYYSLIDWSSTDVLAVALGKSIFLTDNNTGDVVHLCDTENEYTSLSWIGAGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWNNHVLTSGSRDHRILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSKSPILTFDEHKAAVKAMAWSPHKRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDPIAILKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKLFDKPKAKVQPNSLIFDAFNQIR
What is the function of this protein?
Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C).  During telophase and in the subsequent G1 phase of the cell cycle, recognizes and binds proteins containing a destruction box (D-box) and an additional degradation signal termed the KEN box including ASE1, CDC20, the B-type cyclins CLB2 and CLB3, the polo-like kinase CDC5 and HSL1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis.  Required for exit from mitosis, cytokinesis and formation of prereplicative complexes in G1.  Probably is the target of a BUB2-dependent spindle checkpoint pathway.
What are the official names of this protein?
APC/C activator protein CDH1, CDC20 homolog 1, Homolog of CDC twenty 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat CDC20/Fizzy family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Nuclear import and export are mediated by the importin PSE1 and the exportin MSN5.
Protein: THIG_PELPB
Sequence: MDALQLGSYTFSSRLILGTGKFSNATVMLEAVRASGAQLITVALRRFNREQAEDDLFGPLSAIEGVTLMPNTSGASTAAEAIRAAHIARELSGSPFIKVEIHPNPQHLMPDPIETLEAARVLASEGFLVMPYITADPVLAKRLEDVGCASVMPLGSAIGSGQGVATAAMIEIIIRESGIPVIVDAGLRSPSEAANAMEMGCSAVLVNSAVAVAGNPPEMAEAFAEAVAAGRKAFRAGLMQKSGSAIATSPLTAFLGAKG
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS12_SOLM1
Sequence: MPTINQLIRKERAKVSKRRKTPALQACPQRRGVCTRVYTTTPKKPNSALRKVARVRLTNGIEVTSYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHIIRGTLDTSGVSDRRQSRSKYGAKRPK
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: RIBB_SHIFL
Sequence: MNQTLLSSFGTPFERVENALAALREGRGVMVLDDEDRENEGDMIFPAETMTVEQMALTIRHGSGIVCLCITEDRRKQLDLPMMVENNTSAYGTGFTVTIEAAEGVTTGVSAADRITTVRAAIADGAKPSDLNRPGHVFPLRAQAGGVLTRGGHTEATIDLMTLAGFKPAGVLCELTNDDGTMARAPECIEFANKHNMALVTIEDLVAYRQAHERKAS
What is the function of this protein?
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
What are the official names of this protein?
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase.
What is the protein family that this protein belongs to?
Belongs to the DHBP synthase family.
Protein: SYR_BORPD
Sequence: MLPEQQQQLISLIQAAVASVLPDAQAQVLLERPKVAAHGDVATNIAMQLAKPARRNPRELAQGIVDALMAETAARALVENAEIAGPGFINFRITAAARQAVIQAVAEQGEAYGHAPATGEKVLVEFVSANPTGPLHVGHARQAALGDAICRLYAATGRDVTREFYYNDAGNQIQNLAVSVQARARGIAPDSPDYPADGYKGDYIVDIAQDFIARKTLQAADGAAVTASGDVDNLDDIRVFAVAYLRREQDLDLQAFGLAFDNYYLESSLYTSGRVEQTVQALVAKGHTYEQDGALWLRTTELGTGDDKDRVMRKSEGGYTYFVPDVAYHKAKWERGFRHAVNIQGSDHHGTVARVRAGLQALEEGIPKDYPAYVLHKMVKVMRGGEEVKISKRAGSYVTLRDLIDWVGRDAVRYFLIQRRADTEFVFDIDLALSKSDENPVYYIQYAHARICSMIANAGADDARIAQADTALLTAPTEFALMQRLASFPQIVAQAAQELAPHHIAFWLRDCASDFHAWYNAERVLVDDEPLKLARLRLAATTRQVLANGLALLGVSAPQRM
What are the official names of this protein?
Arginine--tRNA ligase, Arginyl-tRNA synthetase, ArgRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DJC16_PONAB
Sequence: MEVRKLSISWQFLIVLVLILQILSALDFDPYKVLGVSRTASQADIKKAYKKLAREWHPDKNKDPGAEDKFIQISKAYEILSNEEKRSNYDQYGDAGENQGYQKQQQQREYRFRHFHENFYFDESFFHFPFNSERRDSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPVWKEVVQELEELGVGIGVVHAGYERRLAHHLGAHSTPSILGIINGKISFFRNAVVRENLRQFVESLLPGNLVEKVTGKNYVRFLSGWQQENKPHVLLFDQTPIVPLLYKLTAFAYKDYLSFGYVYVGLRGTEEMTRRYNINIYAPTLLVFKEHINKPADVIQARGMKKQIIDDFITQNKHLLAARLTSQKLFHELCPVRRSHRQRKYCVVLLTAETTKLSKPFEAFLSFALANTQDTVRFVHVYSNRQQEFAGTLLPDGEAFQGKSAVSILERRNTAGRVVYKTLEDPWTGSESDKFILLGYLDQLRKDPALLSSEAVLPDLTDELAPVFLLRWFYSACDYISDCWDSIFHNNWREMMPLLSLIFSALFILFGTVIVQAFSDSSDERESSPPDKEEAQEKTGKTEPSFTKENSSKIPKKGFVEVTELTDVTYTSNLVRLRPGHMNVVLILSNSTKTSLLQKFALEVYTFTGSSCLHFSFLSLDKHREWLEYLLEFAQDAAPIPNQYDKHFMERDYTGYVLALNGHKKYFCLFKPQKTVEEEEAIGSCSDVDSSLYLGESRGKPSCGLGSRPIKGKLSKLSLWMERLLEGSLQRFYIPSWPELD
What is the function of this protein?
Plays an important role in regulating the size of autophagosomes during the formation process.
What are the official names of this protein?
DnaJ homolog subfamily C member 16, Endoplasmic reticulum DNA J domain-containing protein 8, ER-resident protein ERdj8, ERdj8.
What are the subcellular locations of this protein?
Membrane; Single-pass type IV membrane protein.
Protein: PUR5_ERWT9
Sequence: MTDKTSLSYKDAGVDIDAGNALVDRIKGVVKKTRRPEVMGGLGGFGALCALPQKYREPILVSGTDGVGTKLRLAMDLKRHDAIGIDLVAMCVNDLVVSGAEPLFFLDYYATGKLDVDTAASVITGIAEGCSQSGCALVGGETAEMPGMYHGEDYDVAGFCVGVVEKSEIIDGSKVAEGDVLIALGSSGPHSNGYSLVRKILAFSNTDPETTQLEGKPLADHLLAPTRIYVKNILSLIEQVDVHAIAHLTGGGFWENIPRVLPDNTQAVLDESSWEWPAVFGWMQQAGNVSRFEMYRTFNCGVGMVIALSAADADKALRLMNDAGEKAWKIGVIKASDSEERVVINA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.