PharMolix/UniProtQA huggingface dataset:
Protein: PTA1_SCHPO
Sequence: MEVSETDEHLTRLNQARDIVKTDQSLFPEIVRNILSVANYSDIRYKKWMANFLWFGFSSKNVKFEQKLDLAVTCLDTIVSLYAVDNEEVKKDVISCSCTIYPLVFLHCCTSPNDSSTWDTLTKLKNEIINDFDKGNKPLLISCIKFISCVILTQVPGIRDPRLVTKSDVSLSKVPTHHPFINSNILRIEANDLIEKIFSILFSDSLNVLYITSVLNILPVLVKRRKELAPKIIGSLLEFHLPNPKDEIELSNESKLAIRCIEKNLKLILLHLAKSTGASSSSVEKIHAYLSGQIYHTKVDESLKKRQYEGNISAASKRVKSSAVQSLVERMQPQLSSHDGLQNNPLISIFASQTAINPLANFDVTSIPVEVATEIVLTSLLKIDKNYFHQQINMLRERVRSLSEPESLGLDQQVDEDEDEDYEPPEVDVQTINASVEREAARLEGSAPSNVVTDAFELPTPDSLSPMAILEYFHGALSRLFDYAPQFERSIVSSSNLQNLTLENVDNTVWDKRHWAILLPRLCTRGLLNYQPVTSGEESGDASFTLSSFVRGQLFTYVASNWRSSTNLILNWLSEEWYNDRLMLENPDCHEYEDVKWEGPQYEKWALKVIDSILPYLEAKDKVFMIFMSELPELTDAIVDKIKFVCLDPDKTKLGFMTFQYLIMFRLTCT
What is the function of this protein?
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.
What are the official names of this protein?
mRNA cleavage and polyadenylation specificity factor complex subunit pta1.
What is the protein family that this protein belongs to?
To yeast PTA1.
What are the subcellular locations of this protein?
Nucleus.
Protein: JAP1A_RANDY
Sequence: MFTLKKSLLLLFFLGVINVSLCEEERDADEEERRDDPEERDVEVEKRFFPLALLCKVFKKC
What is the function of this protein?
Antimicrobial peptide.  Has low activity against the Gram-positive bacterium S. aureus (MIC>100 uM) and the Gram-negative bacterium E. coli (MIC=25 uM).  Lacks hemolytic activity against human erythrocytes.
What are the official names of this protein?
Japonicin-1CDYa.
What is the protein family that this protein belongs to?
Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: PUP_MYCBP
Sequence: MAQEQTKRGGGGGDDDDIAGSTAAGQERREKLTEETDDLLDEIDDVLEENAEDFVRAYVQKGGQ
What is the function of this protein?
Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation.  The tagging system is termed pupylation.
What are the official names of this protein?
Prokaryotic ubiquitin-like protein Pup, Bacterial ubiquitin-like modifier.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic ubiquitin-like protein family.
Protein: GM_HHV6Z
Sequence: MASSRVDTINLRIWLVSIICAALSFINVTVHLIAINFPNLGFPCAYFEINDLKAVNLSANNEIYQMTHQLYINPVQIICYVLIMAILFLLIIIYYIVCCAKVFSSNKTSNVNQTTRDITWMGDTSSCFQFILIMDTFQLFVTALSFRLVALGAFAYSIFFVCFTTFNVTLITQFQSADKSFFAFQKIHPNLKGTVQFKTVVINLSELMLGYSTMFLGITTCLGVGNSIYIRSITVAFSSINTFLVMACIYSIVIEAVLVRYVKPLFGYYVGMFCGAVGLSFPILQYETFFESEWSTGLIINLSVVAIISIGFIICRLVRYLVKKKRRYKQLLNAESSSLMDENE
What is the function of this protein?
Envelope glycoprotein important for virion assembly and egress.  Plays a role in the correct incorporation of gH-gL into virion membrane.  Directs the glycoprotein N (gN) to the host trans-Golgi network.
What are the official names of this protein?
Envelope glycoprotein M, gM.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae glycoprotein M family.
What are the subcellular locations of this protein?
Virion membrane; Multi-pass membrane protein. Host Golgi apparatus, host trans-Golgi network. Host endosome membrane; Multi-pass membrane protein. Host nucleus inner membrane; Multi-pass membrane protein. Note=During virion morphogenesis, this protein accumulates in the trans-Golgi network where secondary envelopment occurs.
Protein: RS3A_RAT
Sequence: MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKKPKFELGKLMELHGEGGSSGKTTGDETGAKVERADGYEPPVQESV
What is the function of this protein?
Component of the small ribosomal subunit.  The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.  Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit.  During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity).  May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity).
What are the official names of this protein?
40S ribosomal protein S3a, V-fos transformation effector protein.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Protein: KZ_DROME
Sequence: MGKKVHNAKARQNPQTIVDNSAVKKIQIDVDAVAGGNQVGYDEANALVLPSEKRATKIKVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKRVAHEMNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLKSTPASVIKSWSSMNNKVLRFKRALITKQIHNRQALIDQWNSDPHFLLEEYQNLLYDVALSELTPLWPPVDKKEPQRQ
What are the official names of this protein?
Probable ATP-dependent RNA helicase kurz.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DEAH subfamily.
Protein: PLOD_DROME
Sequence: MRIQQSALLLLLLAVTSQGDAESNWNDKIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWKGGDMQKPGGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAEKYCWPDKSLANDYPEVEGKASRFLNSGAFIGYAPQVFALLVDPIEDTADDQLYFTKIFLDETKRAKLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGNYLARTFNGVCLLCQENLLDLEETNLPVISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLLIYSNVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLHQSDYIFFVDADAHIDDGEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHVTSIYLVKKTAFDAISFKHKEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTVTRPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGWSDGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMNFMVRYRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTHYHEGLLVTNGTRYIMISFIDP
What is the function of this protein?
Forms hydroxylysine residues in collagen type IV (By similarity).  Required for the secretion of collagen type IV (vkg) from haemocytes, fat body and follicle cells (PubMed:23369713, PubMed:20888931).
What are the official names of this protein?
Procollagen-lysine,2-oxoglutarate 5-dioxygenase, Procollagen lysyl hydroxylase.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Secreted, extracellular space. Note=Detected in the ER of fat body cells and haemocytes. Also detected in small puncta in the extracellular space, particularly in the region surrounding the haemocytes.
Protein: LEU1_STRMK
Sequence: MTTIERITTPRIRIFDTTLRDGEQSPGCSMSPPQKLVMARALDELGVDIIETGFPASSQSDREAMALIGRELRRPSLSLAVLSRCLQADIETSARALEAAANPRLHVFLSTSPLHREHKLRMTREQVLESVRKHVSLARSYIDDVEFSAEDATRTELDYLIEVARVAIAAGATTINLPDTVGFTTPEEIRAMFQQVIAGVADVPNAANVIFSAHCHNDLGLAVANSLAAIEGGARQVECTVNGIGERAGNCSLEEIAMVLKVRQAFYEQDSSINTPRIVGTSQLLQRLVGMPVQRNKAIVGANAFAHESGIHQHGMLRHRGTYEIMRPEDVGWEDSQMVLGRHSGRAAVEARLRALGFWLDEDELKLVFEQFKGLCEQQRVVTDADLQTLMQGGSNAQGYRLASMTISDVGSRANALVELSDPDGNRVAETAQGDGPVDALFGALSAATGVQLMLDSYHVHSVGIGADARGEANLSVRHEGVEYDGTGTSKDIIEASALAWLDVANRLLRQRQATAHNSTDVPTPATA
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: PTP17_STYPL
Sequence: WRMIWEHECCVIAVLTRLTEKKKVKCAQYWSETDNKSSKYGEITVKLRETSSCGDYVRRQFELTKNNMTREVVQFQFIAWPDHGIPVTTSSLFRFHKAVVFSQPHTAGPIVV
What are the official names of this protein?
Tyrosine-protein phosphatase 17.
What is the protein family that this protein belongs to?
Belongs to the protein-tyrosine phosphatase family.
Protein: FUT1_RABIT
Sequence: MWPPSRRQLCLAFLLVCALSAFSFLLHLHQDLFRNGLALSLPCLERQPVPAPVAIVCLPVTSPASNASSCAGRPAAPSGIWTIHPDGRFGNQMGQYATLLALAQLNGRRAFILPAMHAALAPVFRITLPVLAPEVNRRTSWKQLLLHDWMSEEYSRLEDPFLKFTGFPCSWTFFHHVREQIRREFTLHDHLREEAQRLLGKLRLGRTGARPRTFVGVHVRRGDYLQVMPQRWKGVVGDRAYLQQAMDWFRARHEAPIFVVTSNGMKWCWENIDASRGDVVFAGNGLESSPAKDFALLTQCNHTVMTIGTFGFWAAYLAGGDTVYLANFTLPDSEFLKIFKPEAAFLPEWVGINADLSPVRTLSGSWRPWRFLG
What is the function of this protein?
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens.  H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (By similarity).  Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).
What are the official names of this protein?
Galactoside alpha-(1,2)-fucosyltransferase 1, Alpha(1,2)FT 1, Fucosyltransferase 1, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1, Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1, Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 11 family.
What are the subcellular locations of this protein?
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Protein: G3P2_METBF
Sequence: MAKAKIAVNGYGTIGKRVADAVRAQDDMEVVGISKTKPNYEAAVAHRLGYDIYAPAANLEAFEKAGMPAAGSIEEMLEKADLVVDCTPGGIGEKNKPIYEKVGIKAIWQGGESHPIAGFSFNAESNYEQAVGRDLTRVVSCNTTALCRAISTIDRELGVNKVRASLSRRAVDPNEIKKGPVDAIVLNPVKLPSHHGPDVRSVLPHINITTAAIKVPTTLMHVHTVNMEVNKDCTAEDVKNIFGSQSRIRLVGQGITSTAEIIEFARDIGRPRHDMWELCIWPESITVTDKELYFFHAVHQESIVVPENVDAIRAMMELESDGAKSIEKTNKAIGLYNK
What are the official names of this protein?
Glyceraldehyde-3-phosphate dehydrogenase 2, GAPDH 2, NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase 2.
What is the protein family that this protein belongs to?
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC2_RAT
Sequence: MLMSLTDSKEGKNRSGVRMFKDDDFLIPASGESWDRLRLTCSQPFTRHQSFGLAFLRVRSSLDSLSDPVKDPSSPGSSGLNQNSSDKLESDPSPWLTNPSIRRTFFPDPQTSTKEISALKGMLKQLQPGPLGRAARMVLSAAHKAPPASVVSPNNSHGEPDSSHPERAEPRAEEPNRKNNASRGKRRKVQEQRRPLSSSSSQPNRRATGRTKQRQQRPQAKSDGSGVQATGQCPICTGSFSIEALPRHAATCGESSPPQPASPTSLSSSESVLRCLHVALTPVPLIPKPNWTEIVNKKLKFPPTLLRAIQEGQLGLVQQLLESGSDPSGAGPGGPLRNVEESEDRSWREALNLAIRLGHEVITDVLLANVKFDFRQIHEALLVAVDTNQPAVVRRLLARLEREKGRKVDTKSFSLAFFDSSIDGSRFAPGVTPLTLACQKDLYEIAQLLMDQGHTIARPHPVSCACLECSNARRYDLLKFSLSRINTYRGIASRAHLSLASEDAMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFELLGMCRNQSEVTAVLNDLGEDSETEPEAEGLGQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLAGWRGSTTIWKLFVAFLIFLTMPFLCIGYWLAPKSRLGRLLKIPVLKFLLHSASYLWFLIFLLGESLVMETQLSTFKGRSQSVWETSLHMIWVTGFLWFECKEVWIEGLRSYLLDWWNFLDVVILSLYLASFALRLLLAGLAYMHCRDASDSSTCRYFTTAERSEWRTEDPQFLAEVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMIDDMIRFMFILMIILTAFLCGLNNIYVPYQETEKLGNFNETFQFLFWTMFGMEEHSVVDMPQFLVPEFVGRAMYGIFTIVMVIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYFREGLTLPVPFNILPSPKAAFYLLRRIFRFICCGSSCCKAKKSDYPPIPTFTNPGARAGPGEGEHVSYRLRVIKALVQRYIETARREFEETRRKDLGNRLTELTKTVSRLQSEVASVQKTVAAGGALRPPDGASILSRYITRVRNSFQNLGPPAPDTPAELTMPGIVETEVSLEDSLDATGEAGTPASGESSSSSSAHVLVHREQEAEGAGDLPLGEDLETKGES
What is the function of this protein?
Thought to form a receptor-activated calcium permeant cation channel.  Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.  Is not activated by intracellular calcium store depletion.
What are the official names of this protein?
Short transient receptor potential channel 2, TrpC2, Transient receptor protein 2, TRP-2, rTrp2.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC2 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: PXPA_STAHJ
Sequence: MRIDLNCDLGEAFGNYSFGGDNQIIPLITSANIACGFHAGDENVMYDTIKLVKDNGVGIGAHPGLPDLKGFGRRNMDITPKEIYNLVVYQLGALDGFCKVHQTRINHVKPHGALYNMGAKDKNIAHAIAQAVYDFDSSLILVGLSNTLLITEAESLGLRTASEVFADRRYEDNGQLVSRKEADAVITNTEEALDQVLKMVIENKVVSKNGKEIDLKADTICVHGDGAHALEFVSQIREKLTKEGIDIQSL
What is the function of this protein?
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
What are the official names of this protein?
5-oxoprolinase subunit A, 5-OPase subunit A, 5-oxoprolinase (ATP-hydrolyzing) subunit A.
What is the protein family that this protein belongs to?
Belongs to the LamB/PxpA family.
Protein: SYF2_RAT
Sequence: MAAVTEVVVPADGAEARPLAAEELAAQKREQRLRKFRELHLKRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELQEEEKKKECAARGEDYEKVKLLEISAEDAERWERRKKKKNPDLGFSDYAAAQLRQYHRLTKQIKPDMESYERQREKHGEDFFPTSNSLLHGTHVPSSEEIDRMVLDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERGTAV
What is the function of this protein?
Involved in pre-mRNA splicing as component of the spliceosome.
What are the official names of this protein?
Pre-mRNA-splicing factor SYF2.
What is the protein family that this protein belongs to?
Belongs to the SYF2 family.
Protein: BIOB_ECOLI
Sequence: MAHRPRWTLSQVTELFEKPLLDLLFEAQQVHRQHFDPRQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLEAERLMEVEQVLESARKAKAAGSTRFCMGAAWKNPHERDMPYLEQMVQGVKAMGLEACMTLGTLSESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVRDAGIKVCSGGIVGLGETVKDRAGLLLQLANLPTPPESVPINMLVKVKGTPLADNDDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPEEDKDLQLFRKLGLNPQQTAVLAGDNEQQQRLEQALMTPDTDEYYNAAAL
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: MLTC_EDWI9
Sequence: MKKVLALALIAPLLISCSGKKPDSNGEEYIKDTNGFDILMGQFAHNIENIWGINEVLIAGPKDYVKYSDRYLTRSHINFETGQITIETIATLNPAETLRQAIVTTLLMGDDPSSIDLYSDANDIKPSREPFLYGQVLDNTGQPIRWSGRANSFADYLLQNKLMKRTSGLHVIYSVTIQLVPNHLDKRAHKYLDMVRRASERYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVMQHTAGKDVFVSKGKWGTPSRSYLFDPEKNIDTGTAYLAILQNTYLGGIQNTTSRRYAVITAYNGGAGSVLRIFSSDKGQAVNIINQMSPGDVYEALTQRHPSAESRRYLYKVNNTQKNYRRIR
What is the function of this protein?
Murein-degrading enzyme.  May play a role in recycling of muropeptides during cell elongation and/or cell division.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase C, Murein lyase C.
What is the protein family that this protein belongs to?
Belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TGT_VIBPA
Sequence: MKLKFDLKKKNGNARRGQLTFERGTVQTPAFMPVGTYGTVKGMTPEEVKGTGAEILLGNTFHLWLRPGQEVMKMHGDLHDFMNWHGPILTDSGGFQVFSLGKMRTITEKGVHFRNPVNGDKIFMDAEKSMEIQKDLGSDIVMIFDECTPYPATHNEAKKSMEMSLRWAQRSRDHFDKLENPNNLFGIVQGGVYEDLRDVSVKGLTEIGFDGYAVGGLAVGEPKEDMHRILEHTCPQLPEDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVTGGVIKIRNAKHKTDTTPLDPHCDCYTCQNYSKSYLHHLERCNEILGARLNTIHNLRYYQRLMESIRKAIDEDRFDEFVQEFYARRDREVPPLSKA
What is the function of this protein?
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr).  Catalysis occurs through a double-displacement mechanism.  The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate.  The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product.  After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase, Guanine insertion enzyme, tRNA-guanine transglycosylase.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family.
Protein: NDRG2_MACFA
Sequence: MAELQEVQITEEKPLLPGQTPEAAKIHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTVIGVGVGAGAYILSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSSLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC
What is the function of this protein?
Contributes to the regulation of the Wnt signaling pathway.  Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor.  May be involved in dendritic cell and neuron differentiation (By similarity).
What are the official names of this protein?
Protein NDRG2, N-myc downstream-regulated gene 2 protein.
What is the protein family that this protein belongs to?
Belongs to the NDRG family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).
Protein: GATB_BACHK
Sequence: MNLETIIGLEVHVELKTNSKIFSASPTEFGAEPNTQTSVIDLGYPGVLPTLNKEAVNFAMKAAMALNCEIATETKFDRKNYFYPDNPKAYQISQFDKPIGENGWIEIEVDGKKKRIGITRLHLEEDAGKSTHTADGSLVDYNRQGMPLIEIVSEPDMRTPEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPVGQEKFGTKAELKNLNSFTYVQKGLEHEQVRQEKELLSGGIIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDLVELYIDDAWKEEVRASIPELPDARKARYVAELGLPAYDAHVLTLTKEMSDFFEATVADGADAKLTSNWLMGEVLAYLNKQQKELKDVALTPAGLSKMVQLIEKGTISSKIAKKVFNELIEKGGDPEEIVKAKGLVQISDEGTLRKVVTEILDNNEQSIEDFKNGKDRAIGFLVGQIMKATKGQANPPLVNKILLEEINKR
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: Y1198_PYRAB
Sequence: MEVIEVVYEDGVFKPLKKIKLKEGTRGVVVVRLPKQISEIAKKYRIKVREDVLEEFLEERR
What is the function of this protein?
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.
What are the official names of this protein?
Putative antitoxin PYRAB11980.
What is the protein family that this protein belongs to?
Belongs to the UPF0165 family.
Protein: GLPE_ECOL5
Sequence: MDQFECINVADAHQKLQEKEAVLVDIRDPQSFAMGHAAQAFHLTNDTLGAFMRDNDFDTPVMVMCYHGNSSKGAAQYLLQQGYDVVYSIDGGFEAWQRQFPAEVAYGA
What is the function of this protein?
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
What are the official names of this protein?
Thiosulfate sulfurtransferase GlpE.
What is the protein family that this protein belongs to?
Belongs to the GlpE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUSA_ECOK1
Sequence: MNTYSITLPWPPSNNRYYRHNRGRTHVSAEGQAYRDNVARIIKNAMLDIGLAMPVKIRIECHMPDRRRRDLDNLQKAAFDALTKAGFWLDDAQVVDYRVVKMPVTKGGRLELTITEMGNE
What is the function of this protein?
Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair.  Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides.  Corrects the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC (By similarity).
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RusA, Holliday junction nuclease RusA, Holliday junction resolvase.
What is the protein family that this protein belongs to?
Belongs to the RusA family.
Protein: EGG1_CAERE
Sequence: MSQQPGSDRRVNFAQEEPMTLGEKISHRMDQFKEMVSSGCCSCASRCPSVAIVLILALVILGILAAIPLTLMLTSSAQRMSTDSTDLSPYSIRHPKFWPKTDKIHFNDLDGIPMSSLFPPNVSTCSGFGFACTGAVHMIIPSSKRCDGIKDCQDGSDEENCKECQSVFSCRSHVEEDSKTKRKTKVLPTLICLTAEKLCNDVQDCPDGSDESVCKSTCSKDQFKCTGNNACLPTSAKCDGVNDCTDGSDEKNCNECQKGAHKCGKQCIKASHVCDGVAQCADRSDEKECDCKSCSGSDKALCEDGTCIKRTQVCDGKKDCTDGMDEENCPGSCSIEAFSTKTKQLTCSDEKRYTESEACSGVVEACEQSCPKCHPKLTFTCPAVGGSQKRCIRRSKVCDGINDCDDGADEKNCTPIKECGIENASQFTCDRKCLDASRRCDGVWDCEDKSDEQNCQQCSSGSIRCAADKKCLPAYTRCNGVAECSDGSDEQKCSCEECLGAHSNTYMCNESNRCLKRDEVCSPYSMCPNATYTDKAYCAALVLKNSGRFPY
What is the function of this protein?
Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial (By similarity).  Seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte (PubMed:16360684).  Conversely, shown to be dispensable for fertilization but required for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane (By similarity).  Appears to recruit or maintain together to the unfertilized oocyte cortex several proteins including chs-1, kinase mbk-2 and pseudophosphatases egg-3, and possibly egg-4 (By similarity).
What are the official names of this protein?
LDL receptor repeat-containing protein egg-1.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the cell membrane of developing oocytes. Plasma membrane localization requires extracellular matrix protein cbd-1. After fertilization, localizes to endosomes in zygotes.
Protein: PA2B2_CRODM
Sequence: SLLQFNKMIKFETRKNAIPFYAF
What is the function of this protein?
Snake venom phospholipase A2 (PLA2) that shows presynaptic neurotoxicity.  PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
What are the official names of this protein?
Basic phospholipase A2 CB2, svPLA2, Phosphatidylcholine 2-acylhydrolase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase A2 family. Group II subfamily.
What are the subcellular locations of this protein?
Secreted.