PharMolix/UniProtQA huggingface dataset:
Protein: T161B_MOUSE
Sequence: MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPSEEELRILAGKQQKGKSKKDRKYNGHIENKPLTIPKDIDLHLETKSVTEVDTLALHYFPEYQWLVDFTVAATIVYLVTEVYYSFMKPTQEMNISLVWCLLVLSFAIKVLFSLTTHYFKVEDGGERSVCVTFGFFFFVKAMAVLIVTENYLEFGLETGFTNFSDSAMQFLEKQGLESQGPVSKLTFKFFLAVFCSLIGAFLTFPGLRLAQMHLDALNMATEKITQTLLHINFLAPLFMVLLWVKPITKDYIMNPPLGRESVPLMTEATFDTLRLWLIILLCVLRLAMMRSHLQAYLNLAQKCVDQMKKEAGRISTVELQKMVARVFYYLCVIALQYVAPLVMLLHMTLLLKTLGNHSWGIYPEAAFPLPVDNNLPANSAYPELPSPDGKMKVTVTQITVALSSLKNIFTPLLFRGLLSFLTWWIAACLFSTSLFGLFYHQYLTVA
What is the function of this protein?
Essential for maintaining normal cardiac rhythm in the developing heart and for neonatal survival (PubMed:33597309).  Inhibits potassium and calcium currents in the cardiomyocytes, this assists in timely action potential repolarization and thereby maintains normal cardiac rhythm (PubMed:33597309).
What are the official names of this protein?
Transmembrane protein 161B.
What is the protein family that this protein belongs to?
Belongs to the TMEM161 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y097_MYCTO
Sequence: MTLKVKGEGLGAQVTGVDPKNLDDITTDEIRDIVYTNKLVVLKDVHPSPREFIKLGRIIGQIVPYYEPMYHHEDHPEIFVSSTEEGQGVPKTGAFWHIDYMFMPEPFAFSMVLPLAVPGHDRGTYFIDLARVWQSLPAAKRDPARGTVSTHDPRRHIKIRPSDVYRPIGEVWDEINRTTPPIKWPTVIRHPKTGQEILYICATGTTKIEDKDGNPVDPEVLQELMAATGQLDPEYQSPFIHTQHYQVGDIILWDNRVLMHRAKHGSAAGTLTTYRLTMLDGLKTPGYAA
What are the official names of this protein?
Putative dioxygenase MT0106.
What is the protein family that this protein belongs to?
Belongs to the TfdA dioxygenase family.
Protein: RL15_BURMA
Sequence: MELNNLKPAEGAKHAKRRVGRGIGSGLGKTAGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFTSLTKEFVGEVRLGDLEKLPVDEIDLLALKQAGLVGELIKSAKIIATGELKRKIVVKGLGATKGARAAIEAAGGSFAE
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.
Protein: CRBN_BOVIN
Sequence: MAGEGDPEDAAHNMGNHLPLLPAEEEEEDEIEMEVEDQDNKEPKKPNIINFDTSLPTSHTYLGSDMEEFHGRTLHDDDSCPVIPVLPQVVMTLIPGQTLPLQLFSPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEVVKVKAIGRQRFKVLEIRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCRIFPSKPVSWEDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKEDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTDHSWFPGYAWTIAQCRICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDDISPDKVILCL
What is the function of this protein?
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2.  Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8.  Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons.  Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity).  May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity).
What are the official names of this protein?
Protein cereblon.
What is the protein family that this protein belongs to?
Belongs to the CRBN family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.
Protein: Y1420_SHELP
Sequence: MKFLVDVHAHTIASTHAYSTVHDYLAVAKEKGIKLFAITDHGPDMADAPHFWHFVNMRVLPRIVDGIGVLRGIEANIKNENGDIDFFGSYLNELDIVLAGFHEPVFQPSTQTTHTQALVNCIESGNVDIISHPGNPAYPIDIKRVAEVAATHNVALEINNSSFLTSRKGSLKNCTAIARAVKEAGGYLVLGSDSHVAFSLGGFDKAIELIQEVDFPIERILNHSPKALLEFLTSRGHKGMDEYAEIV
What are the official names of this protein?
Probable phosphatase Shew_1420.
What is the protein family that this protein belongs to?
Belongs to the PHP family.
Protein: RL1_PROM2
Sequence: MKKLSKRMASLSTKIEDRIYAPLEALSIIKENANAKFDETIEAHIRLGIDPKYTDQQLRTTVALPHGTGQSIRIAVITSGENVSKAKSAGADLFGEEDLVESINKGNMEFDLLIATPDMMPKVAKLGRVLGPRGLMPNPKAGTVTNDIGNAIKEFKAGKLEFRADKAGIVHVRFGKASFTKEALFENLKTLQESIDKNKPSGAKGKYWKSFYVTSTMGPSVQVDINAVQDYQAEG
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: PG137_VARV
Sequence: MTTVPVTDIQNDLITEFSEDNYPSNKNYEITLRQMSILTHVNNVVDREHNAAVVSSPEEISSQLNEDLFPDDDSPATIIERVQQPHTTIIDDTPPPTFRRELLISEQRQQREKRFNITVSKNAEAIMESRSMITSMPTQTPSLGVVYDKDKRIQMLEDEVVNLRNQQSNTKSSNNLDNFTRILFGKTPYKSTEVNKRIAIVNYANLNGSPLSVEDLDVCSEDEIDRIYKTIKQYHESRKRKIIVTNVIIIVINIIEQALLKLGFDEIKGLSTDITSEIIDVEIGDDCDAVASKLGIGNSPVLNIVLFILKIFVKRIKII
What is the function of this protein?
Required for viral crescent formation early during virus morphogenesis.
What are the official names of this protein?
Protein OPG137.
What is the protein family that this protein belongs to?
Belongs to the orthopoxvirus OPG137 family.
Protein: RL20_THEMA
Sequence: MRVKRAVHAKKKRKKYLKAAKGYRGALSRRYKLAKQMYVRSKWYSYVGRKQKKRDMRKLWITRINIAARNEGLKYSELIHGLKLAGVSINRKMLSELAVNDPEAFKEYVKIAKEALAS
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit (By similarity).
What are the official names of this protein?
50S ribosomal protein L20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
Protein: CORA_SALCH
Sequence: MLSAFQLEKNRLTRLEVEESQSLIDAVWVDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDEDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQAMVDGNAYELLLDLFETKIEQLADEIENIYSDLEKLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL
What is the function of this protein?
Mediates influx of magnesium ions (By similarity).  Alternates between open and closed states.  Activated by low cytoplasmic Mg(2+) levels.  Inactive when cytoplasmic Mg(2+) levels are high (By similarity).
What are the official names of this protein?
Magnesium transport protein CorA.
What is the protein family that this protein belongs to?
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SCX12_CENEX
Sequence: MNSLLMITTCLILVGTVWANDGYLFDKRKRCTLECIDKTGDKNCDRNCKKEGGSFGKCSYSACWCKGLPGITPISRTPGKTCRK
What is the function of this protein?
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
What are the official names of this protein?
Toxin Cex12.
What is the protein family that this protein belongs to?
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: MURE_HALH5
Sequence: MVKLVSLLDSLYGYKMIHEGNPDIHSIHMDSREVVEGGLFFCIKGYTVDGHDYAQQAVSNGAVAVVSERPLELSVPVVVVRDSRRAMAQVATKFYGEPTNDLQLIGVTGTNGKTTITHLIEKIMQDQGKMTGLIGTMYTKIGHELKETKNTTPESLVLQRTFADMKKSGVTTAMMEVSSHALQSGRVRGCDFDVAVFSNLTPDHLDYHGTMERYKFAKGLLFAQLGNTYQGKVAVLNADDPASADFAEMTIAQVVTYGIENEADFQAENVRITSTGTTFELAAFEERMELSIHLIGKFSVYNVLAAAAAAYVSGVPLQEIKKSLEEVKGVAGRFETVKHDQPFTVIVDYAHTPDSLENVLKTVGELAKGDVRVVVGCGGDRDKTKRPVMAEIATTFANQAIFTSDNPRSEEPMDILRDMEQGAKGDSYLMIEDRKEAIFKAIELAKEDDIIVIAGKGHETYQQFRDRTIDFDDRIVAQQAIKERWT
What is the function of this protein?
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
What are the official names of this protein?
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase, Meso-A2pm-adding enzyme, Meso-diaminopimelate-adding enzyme, UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase, UDP-MurNAc-tripeptide synthetase, UDP-N-acetylmuramyl-tripeptide synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family. MurE subfamily.
Protein: CYB_TURTR
Sequence: MTNIRKTHPLMKILNDAFIDLPTPSNISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTSTAFSSVAHICRDVNYGWFIRYLHANGASMFFICLYAHIGRGLYYGSYMFQETWNIGVLLLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAAVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGALLLILILLALTLFTPDLLGDPDNYTPANPLSTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILVLIFIPMLQTSKQRSMMFRPFSQLLFWTLIADLLTLTWIGGQPVEHPYIIVGQLASILYFLLILVLMPTAGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: XGPT_PHOPR
Sequence: MSNKFVITWDNMQMYTRQLAEKLLPADQWKGIIAVSRGGLVPAAILARELNIRHVDTVCISSYDHDHQREMKVLKQADGDGEGFIVIDDLVDTGGTAELIRAMYPKAKFVTVCAKPAGKHFIDDYVVDIAQDTWIEQPWDMAVTFVDPISKK
What is the function of this protein?
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi.  To a lesser extent, also acts on hypoxanthine.
What are the official names of this protein?
Xanthine-guanine phosphoribosyltransferase, XGPRT, Xanthine phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ORFC3_PICV
Sequence: MHKTLQMRGPLLPDLLPHNGIVEVTHQPRFQALNLFFSGVVQSEAPSLCCSLAGGSTGRFATGAAFGGGHAALGGVAAWFARSHIAARCGSVAPSRG
What are the official names of this protein?
Uncharacterized protein ORFC3.
Protein: RL11_CHLAB
Sequence: MSNKKVIKLIKLQIPGGKANPAPPIGPALGAAGVNIMGFCKEFNAATQDRPGDLLPVVITVYSDKTFTFITKQPPVSSLIKKALNLESGSKIPNRNKVGKLTQAQVTAIAEQKMKDMDVVLLESAKRMVEGTARSMGIDVE
What is the function of this protein?
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L11.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL11 family.
Protein: CKB11_ARATH
Sequence: MEKYEKLEKVGEGTYGKVYKAMEKGTGKLVALKKTRLEMDEEGIPPTALREISLLQMLSTSIYVVRLLCVEHVHQPSTKSQSTKSNLYLVFEYLDTDLKKFIDSYRKGPNPKPLEPFLIQKLMFQLCKGVAHCHSHGVLHRDLKPQNLLLVKDKELLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTGVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTEQQWPGVSTLRDWHVYPKWEPQDLTLAVPSLSPQGVDLLTKMLKYNPAERISAKTALDHPYFDSLDKSQF
What is the function of this protein?
May control G2/M (mitosis) phase progression.  Plays a role in regulating seedling growth in darkness via regulation of hypocotyl cell elongation and cotyledon cell development.  Plays a role in stomatal development.  Required to suppress endoreduplication.  Together with CDKB1-2, promotes both the last division in the stomatal cell lineage as well as the number of stomata (PubMed:20675570).  In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage (PubMed:24123248, PubMed:24687979).
What are the official names of this protein?
Cyclin-dependent kinase B1-1, CDKB1;1, Cell division control protein 2 homolog B.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: NFUA_ACIAD
Sequence: MSTENTSTAVAEEIPNLLITPSAQEYLGDLLEKQNTPGIGVRIFVENPGTPRAECCMAYSAPDEVNPADYKQEYSDFPAYIDAPSIPYLLDAVIDYNKDRFGGQLTFRAPNSKVPRVGPDASIEERITYILQSEINPGLAGHGGNCALVEVQDDPENGLTAVLKFGGGCQGCSAIDVTLKQGVETTLRQQIPELQRVVDQTDHTQAEGAYFK
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: RIMP_MYCTU
Sequence: MTTGLPSQRQVIELLGADFACAGYEIEDVVIDARARPPRIAVIADGDAPLDLDTIAALSRRASALLDGLDGANKIRGRYLLEVSSPGVERPLTSEKHFRRARGRKVELVLSDGSRLTGRVGEMRAGTVALVIREDRGWAVREIPLAEIVKAVVQVEFSPPAPAELELAQSSEMGLARGTEAGA
What is the function of this protein?
Required for maturation of 30S ribosomal subunits.
What are the official names of this protein?
Ribosome maturation factor RimP.
What is the protein family that this protein belongs to?
Belongs to the RimP family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPPP_DESVH
Sequence: MSDMITAAILGLVEGLTEFLPVSSTGHLIITGELLGFTGPKATTFEVAIQLGAILAVVVLYWDRFWGLLRPQPYVRFAGLRGIMLLLLTSLPASVLGLAAHSTIKAHLFTPSTVAIALAVGAIFMLLVERRTERPRYMTLDEMSPALALGIGCFQCLALWPGFSRSAATIMGGMLLGARRGLAAEYSFIAAVPIMFAATGYDLLKSWTLFTPADLPFFATGFVVSFLSAWAAVKLFIALVGRMTFRPFAWYRLAIAPLVYYFMAY
What is the function of this protein?
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).  Confers resistance to bacitracin.
What are the official names of this protein?
Undecaprenyl-diphosphatase, Bacitracin resistance protein, Undecaprenyl pyrophosphate phosphatase.
What is the protein family that this protein belongs to?
Belongs to the UppP family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RABP1_BOVIN
Sequence: MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLPTWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE
What is the function of this protein?
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
What are the official names of this protein?
Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TREF_ECO7I
Sequence: MLNQKIQNPNPDELMIEVDLCYELDPYELKLDEMIEAEPEPEMIEGLPASDALTPADRYLELFEHVQSAKIFPDSKTFPDCAPKMDPLDILIRYRKVRRHRDFDLRKFVENHFWLPEVYSSEYVSDPQNSLKEHIDQLWPVLTREPQDHIPWSSLLALPQSYIVPGGRFSETYYWDSYFTMLGLAESGREDLLKCMADNFAWMIENYGHIPNGNRTYYLSRSQPPVFALMVELFEEDGVRGARRYLDHLKMEYAFWMDGAESLIPNQAYRHVVRMPDGSLLNRYWDDRDTPRDESWLEDVETAKHSGRPPNEVYRDLRAGAASGWDYSSRWLRDTGRLASIRTTQFIPIDLNAFLFKLESAIANISALKGEKETEALFRQKASARRDAVNRYLWDDENGIYRDYDWRREQLALFSAAAIVPLYVGMANHEQADRLANAVRSRLLTPGGILASEYETGEQWDKPNGWAPLQWMAIQGFKMYGDDLLGDEIARSWLKTVNQFYLEQHKLIEKYHIADGVPREGGGGEYPLQDGFGWTNGVVRRLIGLYGEP
What is the function of this protein?
Hydrolyzes trehalose to glucose.  Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity.
What are the official names of this protein?
Cytoplasmic trehalase, Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 37 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CR002_HUMAN
Sequence: MVRHPYSVQTQLSTEAKAIWRSMQQQETNLLANLTTNDARDNSKDFQNSKVGAAATSRDEGCNCPIIGEIVISCYWLFEIPPLISE
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC00470.
Protein: VAPB_MOUSE
Sequence: MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTVPRRYCVRPNSGVIDAGASLNVSVMLQPFDYDPNEKSKHKFMVQSMFAPPDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENAKPHDVEINKIIPTSASKTEAPAAAKSLTSPLDDTEVKKVMEECRRLQGEVQRLREESRQLKEEDGLRVRKAMPSNSPVAALAATGKEEGLSARLLALVVLFFIVGVIIGKIAL
What is the function of this protein?
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity.  Involved in cellular calcium homeostasis regulation.
What are the official names of this protein?
Vesicle-associated membrane protein-associated protein B, VAMP-B, VAMP-associated protein B, VAP-B, VAMP-associated protein 33b.
What is the protein family that this protein belongs to?
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Protein: HSLU_HAMD5
Sequence: MSDMTPSEIVKKLDDYIIGQDDAKRAVAIALRNRWRRMQLDTELRQEITPKNILMIGPTGVGKTEIARRLAKLAEAPFIKVEATKFTEVGYVGKEVESIIRDLTDTAVKMVRHQAIEKMRDKAKELAQERILDILVSPARNSSGQVEGSQNTSTARQFFLEPLIKGELNEQEIEIDLAVTPVDIEIMSPPGMEEMTNQLQSMFQHMSSQKHKIRKMKIGDALKLLIDEEASKLVNPEELKQVAIHSVEQNGIVFIDEVDKICRHGSKSTSDVSREGVQRDLLPLVEGCTVSTKHGMVKTDHILFIASGAFQVAKPSDLIPELQGRFPIRVELKSLTPKDFERILTEPSASLTYQYKSLMKTEGIKIEFTKDGITSIAGAAGQVNENTENIGARRLHTILERVMEDISYNADKIKKKSITIDSKYVDTHLSKLINNEDLSRFIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LGT_SALPK
Sequence: MTSSYLHFPDFDPVIFSIGPVALHWYGLMYLVGFVFAMWLAVRRANRPGSGWTKNEVENLLYAGFLGVFLGGRIGYVLFYNFPLFLDNPLYLFRVWDGGMSFHGGLIGVILVMIIFARRTKRSFFQVSDFIAPLIPFGLGAGRLGNFINGELWGRVDPNFRFAMLFPGSRAEDIALLPSHPQWQPIFDTYGVLPRHPSQLYELALEGVVLFIILNLFIRKPRPMGAVSGLFLIGYGAFRIIVEFFRQPDAQFTGAWVQYISMGQILSIPMIIAGAIMMVWAYRRRPQQHVS
What is the function of this protein?
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
What are the official names of this protein?
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase.
What is the protein family that this protein belongs to?
Belongs to the Lgt family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COX1_SQUAC
Sequence: MAINRWFFSTNHKDIGTLYLIFGAWAGMVGTALSLLIRAELSQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPVMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAGVEAGAGTGWTVYPPLAGNMAHAGASVDLAIFSLHLAGISSILASINFITTIINMKPPAISQYQTPLFVWSILVTTILLLLSLPVLAAAITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHVVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWETPLLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFIHWFPLFSGYTLHSTWTKTQFLVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYALWNTVSSIGSLISLVAVIMFLFIIWEAFAPSGKVLSVELPHTNVEWLHGCPPPYHTYEEPAFVQVQRTYF
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: CS3HD_PYRFU
Sequence: MSCKAFQGQTLREHIEAMLAAWEIVKNKYIPSIIRVMKTVGVKFTEEDADKFMKTLIILHDVGKCSEVYQKHLSNNEPLRGFRHELVSAYYAYNILKDMFKDETIAFIGALVVMMHHEPILMGQIRSLDKEELTPEVVLDKLRTFNGVMEGTESFIKSMIKEKLGVIPKVPSPTQEDVLREVIRLSVLARHRPDSGKLRMVVGALLIPLVLCDYKGAKEREGESPKFAEVLRVEMMK
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity.  Acts as a ssDNA and ssRNA nuclease, probably with both exo- and endonuclease activities.  Activity is higher for DNA than RNA.  Templates include 2',3'-cAMP and 2',3'-cGMP.
What are the official names of this protein?
CRISPR-associated endonuclease Cas3-HD, CRISPR-associated ss-nucleic acid exo- and endonuclease Cas3-HD.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated nuclease Cas3-HD family.
Protein: SUI1_ORYSJ
Sequence: MSDLDIQIPTAFDPFAEANAGDSGAAAGSKDYVHVRIQQRNGRKSLTTVQGLKKEFSYNKILKDLKKEFCCNGTVVQDPELGQVIQLQGDQRKNVSNFLVQAGIVKKEHIKIHGF
What is the function of this protein?
Probably involved in translation.
What are the official names of this protein?
Protein translation factor SUI1 homolog, Protein GOS2, Protein eIF1, Translation initiation factor 1.
What is the protein family that this protein belongs to?
Belongs to the SUI1 family.
Protein: COBS_HALLT
Sequence: MILTALRGALGFLTRIPVGRDEAAWAAFARSPWTFPVVGYLVGGLVALSLFVPAPAPTVALAFVLAVYAVTGIGHLDGVADIGDAAAVHGDREERRRVLKDSALGVGGTVALALVVLGLATAALGLVEVAATAGDGGPLPPVIGIVVAAEVGAKAATATLVCVGDAPHEGLGSALTGESSPGATLSVFALAAPAALLTWPQVLPGLAALLVALATAALVARWSRRRLGGVSGDVLGATTELARVAALHAGVIAWTRF
What is the function of this protein?
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin).  Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
What are the official names of this protein?
Adenosylcobinamide-GDP ribazoletransferase, Cobalamin synthase, Cobalamin-5'-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the CobS family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.