PharMolix/UniProtQA huggingface dataset:
Protein: CSP3_CAEEL
Sequence: MFFGKLGGFAFFLQRAVRCDGFIDNFFDRIPKFFQFMKSKFPSHQTSSSQADLLVSFSTSPGFLSFKDETKDTWYIQELYRVIIENAKDTHLADLLTETNRRVVEKYEADKVVFVCKQAPEFWSRFTKQLFFMSRNDVF
What is the function of this protein?
Non-catalytic caspase homolog which does not contain the region necessary for caspase activity (PubMed:9857046).  Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4-induced ced-3 processing (PubMed:18776901).  Has no effect on active ced-3 (PubMed:18776901).  Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development (PubMed:18776901).
What are the official names of this protein?
Non-catalytic caspase homolog csp-3.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14A family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: S13A2_RAT
Sequence: MATCWPALWAYRFYLIVLCLPIFLLPLPLIVQTKEAYCAYSIILMALLWCTEALPLAVTALFPIVLFPLMGIMDASEVCIEYFKDTNILFVGGLMVAIAVEHWNLHKRIALQVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMVPIGHAVLEQLQGSKKDVEGGNNNPTFELQEECPQKEVTKLDNGQPVSAPSEPRTQKTQEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSLFPQNGNVVNFASWFGFAFPTMIILLLLAWLWLQVLFLGVNFRKNFGFGEGEEERKQAAFQVIKTQYRLLGPMSFAEKTVTVLFVLLVVLWFTREPGFFPGWGDTVFANEKGQSMASDGTVAIFISLVMFIIPSKIPGLMQDPKKPGKLKAPPAILTWKTVNDKMPWNIVILLGGGFALAKGSEQSGLSEWLGDKLTPLQHIPPSATAVILCLLIAIFTECTSNVATTTLFLPILASMAQAICLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLNIIGVLAITLSINSWSIPIFKLDTFPSWAHSNTSQCLLNPSNSTVPGGL
What is the function of this protein?
Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:9691021, PubMed:9694847).  Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:9691021, PubMed:9694847).  Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:9694847).  Has a critical role in renal dicarboxylate transport (By similarity).
What are the official names of this protein?
Solute carrier family 13 member 2, Intestinal sodium/dicarboxylate cotransporter, Na(+)/dicarboxylate cotransporter 1, NaDC-1.
What is the protein family that this protein belongs to?
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: LIGB_PSEPG
Sequence: MPYLLLFAMLFALNTPLAWAASCPDWTPQKAEAEAAQLQATLTGWDEHYHRQGIALVADELYDQSRQRLVHLQQCFGLAPSPSPLTSARGPLPHPVPHTGVDKLADRQAVARWMAGKTGVWVQPKFDGVAASLIYRQGQLVQLISRGDGLQGHDWSRHIPQLGAVTRQLPQAIDLHLQGELYLRLNEHVQAKAGSANARGTVAGLLARKQLTREQGNTIGLFVWGWPHGPERQADRLAQLAQLGFPDSQHYSIAVDTLEDAARWREHWYRSPLPFASDGVILRLGSRPPAERWQAKAPYWIAAWKYPYVQALAEVRDVRFRVGRTGRITPIAHVQPVTLDDRRITQVSLGSLARWQALDIRPGDQVAISLAGLTIPRLEHVVHRAVERQPLGAPAPGRHHALSCWQPSEGCEEQFIARLTWLSGKQGLALPRTGPGTWRRLVDAGLVTSMTDWLQLDAERLQQVPGISSLTAAQLLGSFDQARSRPFDQWLRGLGAPIGKHLQLTGGWQEMASRSAGQWQTVPDIGVKRSRQLVGFFAAAEVQAIATRLAESGIEGFSPPPERIEQ
What is the function of this protein?
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
What are the official names of this protein?
DNA ligase B, Polydeoxyribonucleotide synthase [NAD(+)] B.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Protein: TRPD_YERP3
Sequence: MMQHLFEKLFRAESMSQEESQQLFAAIVRGELEPSQLAAVLISMKVRGETPAEIAGAAQALLADAQHFPRPDYLFADIVGTGGDGTNSINISTASAFVAASCGVKVAKHGNRSVSSRSGSSDLLAAFGIRLDMSAEQSRLALDDLGVCFLFAPQYHTGFRHAMPVRQQLKTRTLFNVLGPLINPARPPLALIGVYSPELVLPIAQTLKVLGYQRAAVVHGGGMDEVAIHAPTQVAELNNGSIESYQLTPEDFGLNRYPLAALQGGMPEENRDILARLLQGKGETAHAAAVAANVALLLKLYGQENLRHNAQQALEMIHSGQAFDRVTALAARG
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: GUAC_VARPS
Sequence: MQIFDYDNILLLPRKCRVESRSECDASVTLGARSFRLPVVPANMKTVVDEPICLWLAQNGYFYVMHRFDLDNVKFVKQMHAKGVFASISLGVKKPDYDTVDQLVAEGLVPEYITIDIAHGHADSVKNMIGYLKQKLPGSFVIAGNIGTPEAVIDLENWGADATKVGIGPGKVCITKLKTGFGTGGWQLSALKWCARVATKPIIADGGIRDHGDIAKSVRFGASMVMIGSLFAGHEESPGRTVEVDGALFKEYYGSASDFNKGEYKHVEGKRILEPIKGKLADTLIEMEQDVQSSISYAGGRALMDIRKVNYVTLGGDNAGEHLLM
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: YIDC_BURO0
Sequence: MDIKRTVLWVIFFMSAVMLYDNWQRDHGRPSMFFPSATHTAPAAAGGASGTGATTTAGDVPAAAAGAAPSTTAPAAQAQLVKFSTDVYDGEIDTRGGTLAKLTLKKQGDGKQPDLYITLFDHTAGHTYLARTGLLGGDFPNHNDVYTQLNPGSTSLTGDQNTLKLSFESPVKGGVKVVKTYTFTRGSYVIGVDTKIDNVGTAPVTPTVYMELVRDNTAVETPMFSHTFLGPAVYTDAKHFQKIDFSDLDKNKANFEKSADNGWVAMVQHYFASAWIPQQGAKRDIYAEKIDPALYRVGVKQPVAAIAPGQSADVQARLFAGPEEERMLEGIAPGLELVKDYGWVTIIAKPLFWLLEKIHGYVGNWGWAIVLLTVLIKAVFFPLSAASYKSMARMKEITPRMQALRERFKSDPQKMNAALMELYKTEKVNPFGGCLPVVIQIPVFISLYWVLLASVEMRGAPWILWIHDLSQRDPFFILPVLMAVSMFVQTSLNPTPPDPVQAKMMKFMPIAFSVMFFFFPAGLVLYYVVNNVLSIAQQYYITRKLGGVKKKPA
What is the function of this protein?
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane.  Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.  Aids folding of multispanning membrane proteins.
What are the official names of this protein?
Membrane protein insertase YidC, Foldase YidC, Membrane integrase YidC, Membrane protein YidC.
What is the protein family that this protein belongs to?
Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
Protein: IHH_HUMAN
Sequence: MSPARLRPRLHFCLVLLLLLVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTFSDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQPGQYVLVAGVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSLAWGSWTPGEGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS
What is the function of this protein?
The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.  Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity).  Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (By similarity).  Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy.  In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (By similarity).
What are the official names of this protein?
Indian hedgehog protein, IHH, HHG-2.
What is the protein family that this protein belongs to?
Belongs to the hedgehog family.
What are the subcellular locations of this protein?
[Indian hedgehog protein N-product]: Cell membrane; Lipid-anchor. Note=The N-product remains associated with the cell surface. SUBCELLULAR LOCATION: [Indian hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted. Note=Co-localizes with HHAT in the ER and Golgi membrane.
Protein: MURC_BORA1
Sequence: MKHRIQHIHFVGVGGSGMSGIAEVLLNLGYTVSGSDLSESTVTRRLADLGLKVSIGHAAENVADADAIVTSTAVAGDNPEVIAARLARIPVVPRAVMLAELMRLKRGIAVAGTHGKTTTTSLVASVLAAGGLDPTFVIGGRLNSAGANAQLGQGEFIVVEADESDASFLNLLPVMAIITNIDADHMDTYGHDVARLKSAFIEFTQRLPFYGSAVLCADDANVREIMPFVSRPITTYGLSSDAQVRAENVQADGTRMRFSVRRQGREQDLPTLEVELNLPGLHNVRNALAAIAVASELGVADAAICQALAGFKGVGRRFTQWGEFPVAEAQGGGRYSVIDDYGHHPVEMAATLAAARGAWPDRRIVLAFQPHRYTRTRDCFEDFVRVLGTADAVLLTEVYAAGEAPLVAADGRALARALRVAGKVEPLFVEDVAALPQAVRDFMRDGDVLILMGAGSISKVPSQLGEHA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
UDP-N-acetylmuramate--L-alanine ligase, UDP-N-acetylmuramoyl-L-alanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the MurCDEF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_OCEIH
Sequence: MSSVVVVGTQWGDEGKGKITDFLSQNAEVVARYQGGNNAGHTIKFDDVTYKLHLIPSGIFFEDKICVLGNGMVIDPKAFVEEVAYLHERNVSTDNLRISNRAHVILPYHLKLDILQEEDKGANKIGTTKKGIGPAYMDKAARVGIRVADLMDKDAFREKLVQNLKEKNRLFEKVYEADPIQVEEILDEYYAYGQKMAPYVTDTSVVLNDAIDEGKRVLFEGAQGVMLDIDQGTYPFVTSSNPIAGGVTIGSGVGPTKINHVVGVSKAYTTRVGDGPFPTELHDEIGNQIREVGREYGTTTGRARRVGWFDSVVVRHARRVSGITDLSLNSIDVLTGIETLKICVAYRYKGEIMKEFPASLKVLAECEPVYEEMPGWQEDITGAKSLDDLPENARHYLERVSQLTEIPLSIFSVGPDRSQTNVVRSVYRP
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1514_ARCFU
Sequence: MEIMDEIKVNLQKEVSLEEAERYAKNIASKYGDGILLSVHDSKTGYRAPEVYCCGEKPWEVYACNRGANLKISVNQFEFYFRIEVEGQAKY
What are the official names of this protein?
Uncharacterized protein AF_1514.
Protein: MRAY_ACIF2
Sequence: MLYALFMQLGSLYHGFYVFQYLTLRGVLATLTALVLSLFIGPFFIARLRRYKIGQMVRNDGPETHLIKQGTPTMGGALILLVVILTTLLWSDLGNPLVWVAVLTTLAFGAIGFVDDWRKLRRQNSKGLSARAKYGLQSLVAFAAGGVLYALASNPVETSLILPFIPHVLIPMGAGFIVFSYFVIVGTSNAVNLTDGLDGLAIVPTVMVAGALGVFAYVSGNAVFARYLDVPWVPGSGQMLIFCGALVGAGLGFLWFNTYPADVFMGDTGALALGAALAIVAIVARQELVLFIMGGVFVVETLSVIIQVVSFRLTGKRVFRMAPLHHHFEKKGWPEPRVAVRFWIITVILVLVGLSSLKIR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: SYE2_HALHL
Sequence: MTMIRTRFAPSPTGYLHIGGARTALYSWLHTRRHGGRFVLRIEDTDRERSTPEAVNAILEGMAWLGLDYDEGPFYQTERYDRYRQHLQTLLDAGQAYYCYCTKDRLERLRTEQQARKEKPRYDGRCRDLDGPPSEEVADEPVIRFRTPLEGHVVVEDAIRGKVQFLNSELDDLVIARGDGSPTYNFTVVVDDLEMGVTDVIRGDDHLNNTPRQIHLYQALGFEPPRFAHVPMILGEDGKRLSKRHGSVSVLQYRDEGYLPEALLNYLVRLGWSHGDQEVFGVDELIQLFDINEVNHSASTFNPSKLQWLNQQHIMRAEPNHIARHLGPFLAERGVDPAEGPALEAVVRTQQERAKTLVEMADNSLFFYRRPEAYEEKAARKNFKEGTAEILEHCQHCFSGLPSWDAESIHGVVTEAAEAFDVKMGKVAQPLRVAVSGSAVSPPIDATLELLGREETVARVGQAAEWVRQNVG
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase 2, Glutamyl-tRNA synthetase 2, GluRS 2.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CSX1_METJA
Sequence: MQKILIAPWGNFSSWKKVIYSFNGVEKESKSSLSAIYDKINPDKVYILVLDTLSNLESENYGDIVKEVKEKTENFIKENLNIDNYEVIVCPGVGTFYNKDFEKYFKFYGNLTDYYSFALYELSKRLDGDLEVHLDLTHGLNYMPVLTYRVIKDLLEILAIKNKVRLVVYNSDPYVGREKEILNIHTVEDVIIKPSYDIKGMTLDFLDATKFVDKKEIGKIKKEINMNPKIKELRIMKQNINAFIASIVYALPLVYSTFFVKKDKIEIYLNELIGAFISNIKINPEDKILKRYLYFGEGFNSLVKAYFASKISEIPQLIKDELSLEEIDELKNTLFKENPNSQYIKNEISSLYNIINTKYKEEELSEILGNWTPIYKIRRENIDKFKIRNFLAHAGFEKSVTEIYISVENKNGKIELSEKTSLRYNKNYIEEKNGIKRFIFKYKDKNGKVEEINILEKIEEILLNK
What is the function of this protein?
Activated by cyclic oligoadenylate (cOA) to endonucleolytically degrade linear RNA; when cOA levels decrease the RNase activity of Csx1 is abrogated.
What are the official names of this protein?
CRISPR system endoribonuclease Csx1.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated Csx1 family.
Protein: KDSA_RICBR
Sequence: MQKIIKLKDLKIGNDLPFTLIAGPCQIEGLDHALFMAEELVKLTTRLNIPFIYKSSFDKANRTSVNGARGLGIDKGLEVLAEVKRAFNCPIVTDVHSENQCAEVAKIVDMLQIPAFLCRQTDLLQAAAATGKIVNVKKGQFLAPWDMKNVHKKLESFGAKDILLTERGTCFGYNNLVSDMRGLAIMAELNTPVIFDATHSVQQPGGLGGSTGGERKYVELLAKAAVAVGVAGLYMEVHQDPDNAPSDGPCMIRLDNLERVLTKLKKYDEITKEK
What are the official names of this protein?
2-dehydro-3-deoxyphosphooctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the KdsA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEG1_NEUCR
Sequence: MYPPALTLLLTPGLVAAAIQPQAYASSADGRYKLSSYSAPVRGTGTPGSNSTWKLTIDDTPSGRKQTIKGFGAAVTDSTVSVFNALPSAQRTALLNTLMTTAGANFAMMRHTIASSDLSANPAYSYDDSNGQTDLSLSNFNLGGRGNAMASLLAEMRRLQPGLTILGSPWSPPGWMKLNRAIQGTTVNNNLDHAYASQFAQYFVKYLQAYQAKGATIDAITIQNEPLNSRAQMPTMYIYADEAGDLIQNNIGPALRNAGLDTKIWAYDHNTDQPSYPSTVLSRAGGYVPAVAWHCYASSLDWSVLTTFHNAHPGVEQYMTECWTSAKQPTPWNWAASFTMGPLQNWASGVTAWVLGTDTNDGPHLTGSDACDKCTGLVTVDAAAGTYNLRGDYYMMAQFSKFMKKGAVVMSGTGSWTYGDGSGLESVAATNADDGSRVVVIENKFGNEIYVTVEAKSGEVWSGLVYRNSVVTWVLPAAGA
What is the function of this protein?
Partially degrades N. crassa cell wall beta-D-glucan, liberating small amounts of oligosaccharides.
What are the official names of this protein?
Endo-1,6-beta-D-glucanase, Beta-1,6-glucanase Neg1, Glucan endo-1,6-beta-glucosidase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 30 family.
What are the subcellular locations of this protein?
Secreted.
Protein: ALF2_CAEEL
Sequence: MATVGGAFKDSLTQAQKDELHQIALKIVQDGKGILAADESTGTIGKRLDAINLENNETNRQKYRQLLFTTPNLNQHISGVILYEETFHQSTDKGEKFTDLLIKQGIVPGIKLDLGVVPLAGTIGEGTTQGLDKLAERAAAFKKGGCGFAKWRCVLNIGTHTPSHLGMLENANVLARYASICQANGLVPIVEPEVLCDGEHDLARAQKVTEQVLAFVYKALADHHVYLEGTLLKPNMVTPGQSSASKASHEAIGLATVTALRRGVPAAVPGITFLSGGQSELDATANLNAINSVQLGKPWKLTFSYGRALQASVLKAWGGKDENIAAAQKTLLHRSKANGDASLGKYAGEDAAGAAAESLFVAKHSY
What are the official names of this protein?
Fructose-bisphosphate aldolase 2, Aldolase CE-2, CE2.
What is the protein family that this protein belongs to?
Belongs to the class I fructose-bisphosphate aldolase family.
Protein: COAD_HAEIE
Sequence: MTSVIYPGTFDPITNGHLDIIERSAVIFPRVLVAVANSPSKKTLFSLEERVELVRQSVAHLSNVEVFGFSDLLANVIKQHNISAIIRGVRTTIDFEYELQLAALNRLLTKGVESLFFPPAEKWVFVSSTIVREIYLHGGDVAELVPVPVFNALKAR
What is the function of this protein?
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
What are the official names of this protein?
Phosphopantetheine adenylyltransferase, Dephospho-CoA pyrophosphorylase, Pantetheine-phosphate adenylyltransferase, PPAT.
What is the protein family that this protein belongs to?
Belongs to the bacterial CoaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OBP2_RABIT
Sequence: VDPAQVSGSWRTAAIASD
What is the function of this protein?
Binds the chemical odorant, 2-isobutyl-3-methoxypyrazine.
What are the official names of this protein?
Odorant-binding protein 2, Odorant-binding protein II, OBP-II.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
Protein: POL1_ARMVN
Sequence: MWQISEGSQCCCTGKTWSNAEAKEARYVCNCILSCRLVKVEVVPQLPKSRIAPAQDKAERITPLCNSNGGAAPTIPKSKRAFEPRTPLIKQRCDVVVRVGPPADLDLVYPALVQEEVAIPPTEKVLQPTLKAEVRVPIFCAPKRMVAFPKPPTKIASKRDALQFPAGAVAFNGINFIDAKGKVVLSEGAKRILKGIRVAKQQRQRTARRSAACKKVRKARDLALFKRLSEECTFQDLPGGFAGEIPAGHACYRKVAAPTTSFKKEVSKGKKAKKPSTPVLPAQDFSCVDSFDWGEKSSPVEIEDDWVLIEKPVLQRQAAHSAQGRATEALTRFAASGGFTVKAHQKVEELASSGEAGHLIAGEFAELCLRSLVYNDAPVLSASIEELITEQDFKDAIELFNIELAELPTDSTTCGQFNDWASAAKKMAKGVGSIVGDFARMSGAGVLITFDRCIEYLQKKALTFCQKVFNATMAPYLSHLAEASNIISKIWKKLAEWMESLKGKAGLALEVLAQHAIFALGAIVVGGVVVLVEKVLVACKVIPNCGIVLGAFLTLFFASLGLTALECTAEEIFRMHQCCKGAIYSMYSVKEPMNEAEGSSVTMGVLQGLDNAISALTRVGQSMISFKLGSFSYYAKIAQGFDQLARGKKAIGELTGWLIDLVGGVYSKVSGQESTFFDELSTIVCLDVRSWLLKSKRVRLQVETMAIGDRITLDTISKPTGMQGHKILITAAGVPRKTSADFTMCIKEEVSKLEEVHQRTACAGINEGMRQFPFWVYIFGASQSGKTTIANSVIIPSLLEEMNLPKTSVYSRPKTGGFWSGYARQACVKVDDFYAIEQTPSLASSMIDVVNSEPYPLDMAYLHEKGMSMDSPLVVTTANTVKPPTNAGITDEASFFNRRAAVIEVRRKDNTHFTPRAYDNCIEVRFLHNKCAYVDSEGIPQGPAVNTPMEEGWISPSEAVATLKNLLGEHVLAEEEKLLDYRERIGNDHPIYNAAQEFIGNMHYPGQWLTTEQKNTYGINEEGFSFLAVDGKMYKYNVLGKLNPCETVPPHPNVIPWLEEKTLSIVHWDAHKHIATGPRNALVSCFLQGLVQDQSRVQSVDLMGKDSSPEQQAFFKRLTLSERIYLRLCQIRIDAVKKEQLSSVSRGALDVLRDCMYKSKAKLVENYSLLLTLVAILVLIATAYSLISTLIGLAGCSSFAGGMVALNHVSNASIPCSEPRLEEGYIPRNKFVSRISRTRGDGPAQGQGDHEELVTELYYYFDGVKRLISCCWFKGRSLLLTRHQAMAIPIGNEIQVIYADGTERKLVWPGRQEDRSCKGYIEFPDNELVVFEHARLLTMPIKYEKFFVDDPDHQISPNVAVKCCVARLEDGIPQFHFWNKYASARSDVHTIKDEGGSAVYQNKIRRYIIYAHEAKRNDCGAIAVAEIQRTPKVLAMLVSGIGNVTYSSVIPSYSSSFVRGDVPYVPEDGIKTNGYRKVGYLMAKDAPHVPSKTAFMKVPDEICFPYPNPKQPAILSAEDERLIGTVHEGYTPIREGMKKFAEPMHLLDAQLLDEVAGDMVHTWFDAGEILEDVPLSIAINGDVEEEYFDPIAMDTSEGYPEVLQRKNGEKGKARFFVGEPGAREFVPGCGPERAYLSLEEECKTRIPSLVSIETPKDERLKRSKIETPGTRLFSVLPLAYNLLLRVKFLSFSRLLMKKRSHLPCQVGINPYSREWTDLYHRLAEKSDVGYNCDYKGFDGLITEQILAVVATMINAGFRNPVSNQQRSNLLMAISGRLSICGSQVYETEAGIPSGCALTVVINSIFNELLMRYCYKKIVPPIYRECFDRCVVLITYGDDNVFTVSQSIMTSFTGDALKAEMANLGVTITDGKDKSLATIPARPLLELEFLKRGFKKGNGGLIYAPLEKLSIMSSLVYIRSDGSDMLQKLVDNVNTALVELYLHQDREYSESVRDFYLEKLPPGSYKELTTWYEAQIFHECQLSGESGWKPQGLIEVSHGASFASFVQQNGTELERHDICPGLAISGSKYIAREEEILMSLSSLLPGDINAVKLTLKCGDGIGRLPSKASVLSQRKPGIVMQLCARAIKEKKTLVIRDERPYIGGWAMACICGESFGFSIKDTLALYANLMGPNRKNGLATYFTDFDSPVHVKKIHAITNGEEGVAMLKDSFAFCEPTTIAATSCDTRKEMVSHLPTSFPNIVLIGGISYPKEGGEPGALYSPTDVVMSKKLQGVYVSEAVLKCCLRCPGAAVKTVLQTSSPGSSLSQAHFRSLRRVQSHRCMRKS
What is the function of this protein?
Picornain 3C-like protease is a thiol protease that cleaves the P1 and P2 polyproteins.
What are the official names of this protein?
RNA1 polyprotein, P1.
What is the protein family that this protein belongs to?
Belongs to the nepoviruses RNA1 polyprotein family.
What are the subcellular locations of this protein?
[Viral genome-linked protein]: Host endoplasmic reticulum lumen. SUBCELLULAR LOCATION: [Putative ATP-dependent helicase]: Host endoplasmic reticulum membrane; Single-pass membrane protein.
Protein: PRDX3_HUMAN
Sequence: MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ
What is the function of this protein?
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.  Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:7733872, PubMed:17707404, PubMed:29438714, PubMed:33889951).  Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477).  Required for the maintenance of physical strength (By similarity).
What are the official names of this protein?
Thioredoxin-dependent peroxide reductase, mitochondrial, Antioxidant protein 1, AOP-1, HBC189, Peroxiredoxin III, Prx-III, Peroxiredoxin-3, Protein MER5 homolog, Thioredoxin-dependent peroxiredoxin 3.
What is the protein family that this protein belongs to?
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
What are the subcellular locations of this protein?
Mitochondrion. Cytoplasm. Early endosome. Note=Localizes to early endosomes in a RPS6KC1-dependent manner.
Protein: Y4LI_SINFN
Sequence: MKKDTKTARSAVTGKFVTQPIGGKKAAKFAQVEGLKMNAASKALSEKLTASGLKGDAYRSEIVKAFKKG
What are the official names of this protein?
Uncharacterized protein y4lI.
Protein: PUR7_METPP
Sequence: MSATTPLLESRLQSLPLLARGKVRDNYAVGSDRLLMVASDRLSAFDVVMGEPIPGKGELLTRMALFWFARLGHIVPNHLTGDAPESVVSAAERSQVTGRSMLVKRLKPLPVEAVVRGYLAGSGWKEYQHNGQVCGVKLPPGLKNASKLPSPIFTPATKAEMGEHDENIPFERMVEIIGAPLAEQVRRVAIALYETAAAFALGKGIIIADTKFEFGLDEAGTLTLMDEVLTPDSSRFWPVEGYAEGINPPSYDKQFVRDWLEQAVVDGRPWNKQAPAPALPADVVARTAAKYREALERLTA
What are the official names of this protein?
Phosphoribosylaminoimidazole-succinocarboxamide synthase, SAICAR synthetase.
What is the protein family that this protein belongs to?
Belongs to the SAICAR synthetase family.
Protein: TX90A_PHOKE
Sequence: ACLARGETCKDDCECCDCDNQCYCPFDWFGGKWHPVGCSCAHANKYFCDHKKEKCKKA
What is the function of this protein?
No toxic effects on mice at dose levels of 5 ug per mouse.  May be toxic to insects.
What are the official names of this protein?
U8-ctenitoxin-Pk1a, U8-CNTX-Pk1a, Probable neurotoxin PKTx23C3.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 09 (Tx3-6) family.
What are the subcellular locations of this protein?
Secreted.
Protein: RS16_CAEEL
Sequence: MTSTVQSVQTFGRKKTATAVAHCKKGQGLIKVNGRPLEFLEPQILRIKLQEPLLLVGKERFQDVDIRIRVSGGGHVAQIYAVRQALAKALVAYYHKYVDEQSKRELKNIFAAYDKSLLVADPRRRESKKFGGPGARARYQKSYR
What are the official names of this protein?
40S ribosomal protein S16.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
Protein: MVHD_METTH
Sequence: MAEDDIKIVMFCCNWCSYGGADTAGTARMQYPTNIRVIRVMCSGRIEPQFVLKAFREGADGVLVTGCHHGDCHYDAGNYKLDRRMRLIYKLADELGIGRERIHHDWISASEGEKFAETVKMMVNRIKDLGPSPIKKQLAEA
What is the function of this protein?
Part of a complex that provides reducing equivalents for heterodisulfide reductase.  MvhD may form the contact site to heterodisulfide reductase (By similarity).
What are the official names of this protein?
F420-non-reducing hydrogenase iron-sulfur subunit D, Methyl viologen-reducing hydrogenase subunit delta, MVH subunit D.
What is the protein family that this protein belongs to?
Belongs to the MvhD/VhuD family.
Protein: FIMDH_DICNO
Sequence: MFKKFLWRDCVFIIVLITTIALPAYIHTNYPQAFSRFFYPVEAWFTKRDLRCSKNAPHFLRQLLIEMIDEQKSLNNQVAFWHNGQLFHCESGWEDGFRGEKPMRVNSRFRYASVTKVLTSALVLHAINEQKLSLDSKIIELLELPAPKDPRVAAITIKMLLEHSAGFDRLKTYTPMLTMDVKPWCPTNLAQLSETKLDFDPETQFQYSNVGYCLLGAAIEKAYGRSFQSVAEDYFQLKKYGVSYVGDGFLPDEIQYDYRFEPFYAESYSKHFDFKDSLYAVGGLSGSAADIVQLLAALPKETPLTIFSHNHAPCSINILDACYGYALQPYQASRQSYTLWGKSGFFPGVNTDVFLDEQGNILATFRAASTKKTADTLLLRQYAYSLMNEYVNQK
What are the official names of this protein?
Probable fimbrial assembly protein FimD, serogroup H1.
Protein: ASIP_HUMAN
Sequence: MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC
What is the function of this protein?
Involved in the regulation of melanogenesis.  The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).  In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition.  Could well play a role in neuroendocrine aspects of melanocortin action.  May have some functional role in regulating the lipid metabolism with adipocytes.
What are the official names of this protein?
Agouti-signaling protein, ASP, Agouti switch protein.
What are the subcellular locations of this protein?
Secreted.