Protein: PAR14_MOUSE
Sequence: MAASGSFPLLVEGSWGPDPPKNLINKLQVYFQSRKKSGGGECEVVPEPGNPARFRVLFSPEDVRQNVLERGNHELVWQEKGTFKLTVLMPTDPEEASASKKSRKESPEEESKTKEDAVKQGDLDITHSPSSGSEKTEDVPKECENISSMVAFENLPEKVSEMVLTILVENISGLPSDDFKVEVNRDFAVAVVTFQKPIDIKKFIVDCISHRSNQQLQLAPRLLETTNVVRVENLPPGVDEYQLQLFFENPFNGGGRVARVECFPEESSALVEFCDSKVLDTVMAKTHSYNKMPLSVFPYYPSLGTALYGEEKPLIKLPASFQESLDLPLWKFFQKNNHLIEEINNEMRCCHCELTWSEINGKLTIRPAATLVNHRLSIKTWQRDASAVLSGIKSKYGVELFEVCSPVWDIIKHELESGDDRVLVEFEKESLNIAGKSEDVQGMSQKIRELIESTTEKLRREEQSLKEKVAISPGKHYLLHHSGFLKDLSKGFPEMEISYDATAQFLYLKGFRADVYKVKCDIQEKVFSMAQKDVQVSSEVFEFLQQVDSQRLSKSLFEAQNILAIYELKGTALFLVGSSFKDLAEAETKMLSALSHKQIEVEDKEVLISNGWKKKVHPLQKRHSSCATIIVQNELTSETPAKVIVTGCVKEVNEIHRQLFEYLENNMKVERALKIKPSLIVDYLRTDKRLLSKIKKAHVYVHFKPKDNPNSILLTGCKSKVLECMNLVKEIQDSVCVQRFQTDKAGVRHFFKDKESYYKTEIGRQFGCVIELEEDREEKGEEEDGEEEEGEEEGESSINEQKCHLQRDIAPGVKLFVLEEDLSRFPVDVVVNAANENLKHISGLAQALSKAAGPELQTECDQIVKEGGVVLPGNAVISKAGKLPCHHVIHAVGPRWKGDKVLECVSLLKKVVRQSLSLAEEHRCRSIAMPAVSAGIFDFPLELCVANIVSAIKEHFQHKRDTHTLKKIYLVGLPAKVARAFAEAVKTTYKDSLSHTAFPSSLKALVPLGKTPQKQGSLLVSPEGLRIRLVEEGVQNATTHAIVNSISPDLKLNKGPLSQAFLEKAGPKLQEELTRSGQGVSVDVGTILQTSGCNLNSRHVFHVVPPPWKSNNSAWSLKIMKNIIRDCLKTTENLSLQSIAFPAIGTGNLRFPKPEFAKLIISEVLKFSSRNQLKTLQEVQFLLHPKDHENIQAFSDEFDKRNNGDPSDKNPKAEDTQGIYGSLSSPTLGMHEMNIGPILFQVATGNIIKEVADVIVNSTTLTFDLKSGVSKAILEGAGQNVEQECSLLAKQSNHGYIVTGGGLLQCKNIIHVVGGNDVKKSVSCVLEECEQRNYSSICLPAIGTGNAQQDPNVVAKAIIDAIEEFVQKKSVQAVKRVKVVIFQPHILQFFYDNMKEREGSPAPPKQSPAKQSVMSKIASFLGFPKQASPKKNTLVLEKKIEHTVFQVCGSGVDSVNKTISWLKELITKEQLSYTNDDECVSDFDMEEYEKLNEIQKELNITIEMNQKKTSIQVSGISRDVIKARDEIEGMIKSIRLAKEKESQADYISTYVEWQYIDKNITQCFDKMTNMKLEVAWKAKKKDTVVQIHNQDFTVDLSTNTATAPQGQTFTVQRLVKAEAEIPANWSDMKQDKLLLVNLQTSDPEYNMVASAFRQTCSNFFIEKIERIQNPALWRRYQAYKKSMDEKNGNVRNEKHLFHGTEASSLPQLNSNGFNRSYAGKNATAYGKGTYFAVKASYSACDTYSRPDTNGRKYMYYVRVLTGNYTNGNASLIVPPSRDPQNAADLYDTVTDNDKNPSIFVVFYDNQTYPEYLITFRQ
What is the function of this protein?
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:27796300).  In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity).  Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation (PubMed:27796300).  However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569).  Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300).  In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300).  Mono-ADP-ribosylates PARP9 (By similarity).
What are the official names of this protein?
Protein mono-ADP-ribosyltransferase PARP14, ADP-ribosyltransferase diphtheria toxin-like 8, ARTD8, Collaborator of STAT6, CoaSt6, Poly [ADP-ribose] polymerase 14, PARP-14.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=In steady state cells the protein is mostly nuclear (PubMed:16537510). A minor proportion is detected in the cytoplasm (PubMed:16537510). In macrophages, mainly localizes to the cytoplasm (By similarity).