PharMolix/UniProtQA huggingface dataset:
Protein: GYRA_STRP3
Sequence: MQDRNLIDVNLTSEMKTSFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRHMLVDGHGNFGSMDGDGAAAQRYTEARMSKIALELLRDINKNTVNFQDNYDGSEREPVVLPARFPNLLVNGATGIAVGMATNIPPHNLAESIDAVKMVMEHPDCTTRELMEVIPGPDFPTGALVMGRSGIHRAYDTGKGSIVLRSRTEIETTQTGRERIVVTEFPYGVNKTKVHEHIVRLAQEKRLEGITAVRDESSREGVRFVIEIRREASATVILNNLFKLTSLQTNFSFNMLAIENGVPKILSLRQIIDNYISHQKEVIIRRTRFDKDKAEARAHILEGLLIALDHLDEVIAIIRNSETDVIAQTELMSRFDLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLSDILAKPERIITIIKEEMDEIKRKYANPRRTELMVGEVLSLEDEDLIEEEDVLITLSNKGYIKRLAQDEFRAQKRGGRGVQGTGVNNDDFVRELVSTSTHDTLLFFTNFGRVYRLKAYEIPEYGRTAKGLPIVNLLKLEDGETIQTIINARKEETAGKSFFFTTKQGIVKRTEVSEFNNIRQNGLRALKLKEGDQLINVLLTSGQDDIIIGTHSGYSVRFNEASIRNMGRSATGVRGVKLREDDRVVGASRIQDNQEVLVITENGFGKRTSATDYPTKGRGGKGIKTANITPKNGQLAGLVTVDGTEDIMVITNKGVIIRTNVANISQTGRATLGVKIMKLDADAKIVTFTLVQPEDSSIAEINTDRENSISKNKDN
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit A.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrA/ParC subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SLYX_SHESH
Sequence: MDQLERRIEDLEMKLAFQEGTIEELDQQVIKLNDLMAAQQQQLRILITKLQSVEPSNMANQSEESPPPHY
What are the official names of this protein?
Protein SlyX homolog.
What is the protein family that this protein belongs to?
Belongs to the SlyX family.
Protein: GYRB_HALVD
Sequence: MSQDNEYGAGQIQVLEGLEAVRKRPAMYIGSTDSRGLHHLVYEVVDNSIDEALAGHCDAIEVALHEDGSVSVTDNGRGIPVDTHEQYDRPALEVIMTVLHAGGKFDNKSYQVSGGLHGVGVSVVNALSSELEVEVKRDGAVWTHRFEVGEPQVEEFERVRDLEPGEDTGTTIRFWPDDGIFETTEFDFKTLENRLRELAFLNSGVEISLSDERTDESSTFLFEGGIREFVEYLNETKTALHDDVIYYDDESEGIEVEIAMQATDELQGSIHAFANNINTREGGTHLTGFKTALTRVVNDYANTHDMLDDLDGDNLRGEDVREGLTAVISIKHPDPQFEGQTKTKLGNSEVRGIVESVTHQQLGTFFEENPDTATAIISKAVEAARARKAAKQAEELTRRKSALESTSLPGKLADCQSRDPAESELFIVEGDSAGGSAKQGRDRKFQAILPLKGKILNVEKHRLDRILENDEIRALITAIGGGVGDEFDIEKARYQRLILMTDADVDGAHIRTLLLTLLYRHMRPLIEAGYVYAAQPPLYRVRYRGNTYDAMDEAERDRIIEEECNGNPTQVQRFKGLGEMNPDQLWDTTMNPENRVLKRITVEDAAAADRMFNILMGDAVGPRKQFIKDHANDAEWVDI
What is the function of this protein?
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.  Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation.  Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings.  Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
What are the official names of this protein?
DNA gyrase subunit B.
What is the protein family that this protein belongs to?
Belongs to the type II topoisomerase GyrB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDGA_SACS2
Sequence: MGRQGNLEELWCLRMPEIITPIITPFTKDNRIDKEKLKIHAENLIRKGIDKLFVNGTTGLGPSLSPEEKLENLKAVYDVTNKIIFQVGGLNLDDAIRLAKLSKDFDIVGIASYAPYYYPRMSEKHLVKYFKTLCEVSPHPVYLYNYPTATGKDIDAKVAKEIGCFTGVKDTIENIIHTLDYKRLNPNMLVYSGSDMLIATVASTGLDGNVAAGSNYLPEVTVTIKKLAMERKIDEALKLQFLHDEVIEASRIFGSLSSNYVLTKYFQGYDLGYPRPPIFPLDDEEERQLIKKVEGIRAKLVELKILKE
What is the function of this protein?
Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway.  Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively.  It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal).
What are the official names of this protein?
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase.
What is the protein family that this protein belongs to?
Belongs to the DapA family. KDPG aldolase subfamily.
Protein: RNZ_PSEE4
Sequence: MDLQFLGTSSGVPTKARNVSATAVIEATGHGWYLVDCGEGTQHQLLRSPLSMRDLRAIFITHVHGDHCFGLPGLLASAGMSGRKAPLPLIMPTALHDWVRQGLAASDTYLPFELQLQALETFDGFTCGNIQVGKVELSHRVPSYGFVFDEQDPEPRLDTARLQADGVPAGPLWGQLARGMTVEHEGRQLDPQHYLQPQRPPQRIIVCGDNDRPELLAELAKGVDVLVHESTFTEPVVERAQATFGHSTAAAVARFAEAAQVPNLVLTHFSARYQGAGAARGSSIEDVREEALAHYRGNLVLAQDLQRYHLARDGRLVEVL
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: CLSA_PSEA8
Sequence: MAATGVDKDRPRAMTSTTYLGLLLVGIQVLGFVAAIHAVLTVRTAQGAIAWATSLVFMPYLTLLPYLVFGRSRFDAYIEARRQANREMHLAAAELDWRPWVEEALAARQVSGYKGLKALVRMTRTPTLANNRVRLLVNGEASFEAMFKAISAARQVILVQFFIVRDDALGQRLQQLLLERAANGVEVFFLYDAIGSHALPHRYVERLRQGGVQMHGFSTGSGMLNRFQVNFRNHRKVVVVDGECGFVGGHNVGVEYLGEKPPLAPWRDTHMELRGPAVACLQESFAEDWYWATHSLPPLILPPQYDSEGALCQVVASGPADAQETCSLFFVEMINAAHERVWITSPYFVPDEAVMAALRLAVLRGVDVRLLIPSRPDHRTVYAASSLYALEAIRAGVKVFRYQPGFLHQKVVLVDRDTAAVGSANLDNRSFRLNFEVMVVTVDEGFAGEVEAMLEADFAESLEFTPEDRRSVRRLQQLGMRVARLVSPIL
What is the function of this protein?
Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
What are the official names of this protein?
Cardiolipin synthase A, CL synthase.
What is the protein family that this protein belongs to?
Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DEOB_AGRVS
Sequence: MARAFLFVLDSFGVGGAPDAPAYGDDGADTLGHIAEFCAAGAGDRDGLRAGPLMLPNLSALGLLQIASLASGSLPAGMALPERVFGLYGAANEISRGKDTPSGHWEIAGTPVMFDWGYFPQEGDAFPADLVADICKRADLPGILGNCHASGTDILARLGEEHCRTGQPICYTSSDSVFQIAAHEHVFGLERLLRLCEIVRELLTPYRIGRVIARPFIGNSASNFQRTGNRRDYSVPPPEPTLLDRLSEAGRTVHAIGKIGDIFAHQGTGRDIKANGNAALMEATLAVMDEAADGDLVFTNFVDFDMLYGHRRDVPGYAAALEAFDLWLPDVYRKLIPGDMVILTADHGCDPTWRGTDHTRERVPIMAFGPGIRARSIGIRDTYADIGETIAAHLGIAPGRHGMSFL
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PLSY_PSEAE
Sequence: MVWLLAILAYLLGSLSFAVLLSRWFGTQDPRASGSGNPGATNMLRVAGKKLAILTLLGDVGKGLLPVLVARWLGLGVMEEAWVGIAAVIGHLYPLYFNFRGGKGVATAAGMLLGLYPPAVLLAAAAWLLTFKLSRTSSLASLVATPLTLPLLAWQQPGALLPMTVLTGLIVWRHRANLRDLFAGRERHF
What is the function of this protein?
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA).  This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
What are the official names of this protein?
Glycerol-3-phosphate acyltransferase, Acyl-PO4 G3P acyltransferase, Acyl-phosphate--glycerol-3-phosphate acyltransferase, G3P acyltransferase, GPAT, Lysophosphatidic acid synthase, LPA synthase.
What is the protein family that this protein belongs to?
Belongs to the PlsY family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GLO2_SHIB3
Sequence: MNLNSIPAFDDNYIWVLNDEAGRCLIVDPGDAEPVLNAIAANNWQPEAIFLTHHHHDHVGGVKELVEKFPQIVVYGPQETQDKGTTQVVKDGETAFVLGHEFSVIATPGHTLGHICYFSKPYLFCGDTLFSGGCGRLFEGTASQMYQSLNKLSALPDDTLVCCAHEYTLSNMKFALSILPHDLSINDYYRKVKELRAKNQITLPVILKNERQINVFLRTEDIDLINVINEETLLQQPEERFAWLRSKKDRF
What is the function of this protein?
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
What are the official names of this protein?
Hydroxyacylglutathione hydrolase, Glyoxalase II, Glx II.
What is the protein family that this protein belongs to?
Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
Protein: CKLF4_HUMAN
Sequence: MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
What is the function of this protein?
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity.  May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
What are the official names of this protein?
CKLF-like MARVEL transmembrane domain-containing protein 4, Chemokine-like factor superfamily member 4.
What is the protein family that this protein belongs to?
Belongs to the chemokine-like factor family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TMCAL_STAA8
Sequence: MKSVGLITEYNPFHNGHQYHINQSKKLTNADVTIAIMSGNFVMRGEPAIYNKFTRAKMALSTADLVIELPATASLSSGDHFAELAVKVADYMSVDTIAFGSENNDIKTLKQLAHSINEIEQSESFSQKVKEGKSYPRIISELLEHHEALASPNNILGISYLKAIAKNAKNINAISIKRENAQHHDSLIQHHQFASGTSIRTSIISQDDHWHHVVPKDIQHLYVTPHITLNQIFPYLKYQIIAMTTDSLKNIYTVTEGFENRLKSNIYEATDFHHFVKLLKTKRYTYTHIQRLLMNVLLNIKPTDVTSNIHAVKVLAMNDRGRQYLKHLKTAFPERQYITNINKSNAHYFTNEIKATHIYNAISGQQQTDFNTPVIQQYR
What is the function of this protein?
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates.  First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
What are the official names of this protein?
tRNA(Met) cytidine acetate ligase.
What is the protein family that this protein belongs to?
Belongs to the TmcAL family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RECO_STRSY
Sequence: MERIETRGLVLYNRNFREDDKLVKIFTEKAGKRMFFVKHASKSKLVASIQPLTYADFIVKINDDGLSYIEDFHQVQPFKNINGDIFKLSYATYILALADAALQDKVYDPALFAFLVKTLDLMESGLDYEVLTNIFEIQLLGRFGISLNFHECAFCHRVGLPFDYSYKYSGVLCPQHYQQDERRAYLDPNVPYLLDQFQAISFDELETISIKPEMKRKLRFFIDQLYEEYVGIHLKSKKFIDDLSSWGQIMKPRTENEETE
What is the function of this protein?
Involved in DNA repair and RecF pathway recombination.
What are the official names of this protein?
DNA repair protein RecO, Recombination protein O.
What is the protein family that this protein belongs to?
Belongs to the RecO family.
Protein: DEF_STRGC
Sequence: MSVIEKLIKPAHLIDMRDIIREGNPTLRAVAEEVSFPLADEDILLGEKMMQFLHNSQDPVMAEKLGLRGGVGLAAPQLDISRRIIAVLLPNPEDENGNSPQEAYALKEVMYNPKIVAHSVQDAALADGEGCLSVDRDVPGYVVRHARVTVDYFDKNGEKHRVKLKGYKAIVVQHEIDHINGIMFYDRINETDPFAIKEGMLILE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: STAD2_OPHAA
Sequence: MELHLALRASPLPAADPGRRPPPPRGNFATNCTAAINSTHISQEKFRSLDSWVEHNMLTFLKPVEKCWQPQDFLPDPSHLSAEELGDAVREIHERAAEIPDEVWVCMVGNMVTEEALPTYQSLISSVLGGTVAGSTPWDRWIRGWSAEENRHGDLLNKYLYLTGRLDMRQVEKTIQYLIGSGMDVGVGNSILCGFIYTCFQEKATFIPHGNTARLAKHHGDTTLAKICGLVAADEKRHAAAYTNLMRKLFEVDPNESMLAFAHVMQARVTMPASRMFDGRDPHLFTHFSDVSQKIGVYTVGDYSEMLDFFLKEWDISAIVDGLSPEGRRVQEYVCGLPEVMRKLAERADDRRKKLVNVGEPRYIPFSWIFNKQVRV
What is the function of this protein?
Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain.  Converts palmitoyl-ACP to (4Z)-hexadec-4-enoyl-ACP by introduction of a cis double bond between carbons 4 and 5 of the acyl chain.  Catalyzes the desaturation of saturated fatty acid 18:0 and 16:0 to generate 18:1 (delta-9) and 16:1 (delta-4) intermediates, expected to give rise to 9-alkenes and 12-alkenes, respectively.
What are the official names of this protein?
Palmitoyl-[acyl-carrier-protein] 4-desaturase 2, chloroplastic, Acyl-[acyl-carrier-protein] desaturase 2, Stearoyl-[acyl-carrier-protein] 9-desaturase 2, Stearoyl-ACP desaturase 2.
What is the protein family that this protein belongs to?
Belongs to the fatty acid desaturase type 2 family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: YADW_ECOLI
Sequence: MAIIIGLEFAQLPMSFGAKYE
What are the official names of this protein?
Protein YadW.
Protein: PCAT2_RAT
Sequence: MNRCAEAAAVAATVPGSGVGDSGLRPPMVPRQASFFPPPVPNPFVQQTRISAARRLQMILLGIILLPVRALLVGLVLLLAWPFAVISTVCCPKKLTHPISDWRRKITQPALKFLGRAMFFSMGFRVTVKGKVASPLEAPIFVVAPHSTFFDGIACVVAGLPSLVSRNENAQTPLVGRLLRALQPVLVSRVDPDSRKNTINEIKKRAMSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCVLTFCQLFTKVEVEFMPVQAPSEEERNDPVLFASRVRNLMAEALEIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGIRKHLDEYASIASSAKGGRIGASSAKGGRIGPVSDVLRQLFALFDRNNDGSIDFREYVIGLAVLCNPANTEDIIQVAFKLFDVDEDGYITEEEFCTILQASLGVPDLNVSGLFREIAQGDSVSYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPEDVQTAPSVASNKVSPESHEEGTSGKKVD
What is the function of this protein?
Exhibits both acyltransferase and acetyltransferase activities (By similarity).  Activity is calcium-dependent (By similarity).  Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity).  Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity).  Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (By similarity).  Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity).  Under resting conditions, acyltransferase activity is preferred (By similarity).  Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity).  Involved in the regulation of lipid droplet number and size (By similarity).
What are the official names of this protein?
Lysophosphatidylcholine acyltransferase 2, LPC acyltransferase 2, LPCAT-2, LysoPC acyltransferase 2, 1-acylglycerol-3-phosphate O-acyltransferase 11, 1-AGP acyltransferase 11, 1-AGPAT 11, 1-acylglycerophosphocholine O-acyltransferase, 1-alkenylglycerophosphocholine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acetyl-CoA:lyso-platelet-activating factor acetyltransferase, Acetyl-CoA:lyso-PAF acetyltransferase, Lyso-PAF acetyltransferase, LysoPAFAT, Acyltransferase-like 1.
What is the protein family that this protein belongs to?
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Lipid droplet.
Protein: RS15_ALKOO
Sequence: MIQENKKTIIDTFKTHENDTGSPEVQIALLTERINHLNEHLKSHKKDFHSRRGLLKMVGKRRNLLNYLKDRDIERYREIIAKLGLRK
What is the function of this protein?
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
What are the official names of this protein?
30S ribosomal protein S15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
Protein: MSP1_CAEEL
Sequence: MTDRNELIGVAIRVVAAAAVSFLSVRYLVKYLDPNYSVNEESKKKVAQLFHELGIDRQIELSEHEIRIATQFVGGEDVGADWDEIGGCEELVAELKDRIILPLRFASQSGSHLLSPPRGILLYGPPGCGKTLLAKAVARAAGCRFINLQVSNLTDKWYGESQKLAAAVFSVAQKFQPTIIFIDEIDSFLRDRQSHDHESTAMMKAQFMTLWDGFSSSGDQIIVMGATNRPRDVDAAILRRMTARFQVPVPNAKQRSQILNVILRNEKINNTVNLGEIAQAAEGLSGSDLKEVCRLALLARAKATVASGGSVNQLLPLEQSDFESAVHKYMRAAHLLVEETLD
What is the function of this protein?
Involved in intramitochondrial sorting of proteins.
What are the official names of this protein?
Mitochondrial sorting homolog.
What is the protein family that this protein belongs to?
Belongs to the AAA ATPase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.
Protein: FADB_VIBC3
Sequence: MIYQAKTLQVKQLANGIAELSFCAPASVNKLDLHTLESLDKALDALAADSSVKGLLLSSDKEAFIVGADITEFLGLFAKPEAELDEWLQFANRIFNKLEDLPFPTLSALKGHTLGGGCECVLATDFRIGDATTSIGLPETKLGIMPGFGGTVRLPRLIGADSAMEIITQGKACRAEEALKVGLLDAIVDSDKLIDSAITTLTQAIEEKLDWQKRRQQKTSALTLSKLEAMMSFTMAKGMVAQVAGKHYPAPMTSVVTIEEAARLPRDAALDIERKHFIKLAKSTEAQALVGIFLNDQYIKGLAKQSAKAASQDTQHAAVLGAGIMGGGIAYQSALKGVPVLMKDIAPHSLELGMTEAAKLLNKQLERGKIDGFKMAGILASITPSLHYAGIDQADVIVEAVVENPKVKAAVLSEVEGLVDAETILTSNTSTIPINLLAKSLKRPQNFCGMHFFNPVHRMPLVEIIRGEHTSEDTINRVVAYAAKMGKSPIVVNDCPGFFVNRVLFPYFAGFSLLMRDGANFTEIDKVMERQFGWPMGPAYLLDVVGIDTAHHAQAVMAEGFPTRMAKSGREAIDALYEAKKFGQKNGSGFYQYTVDKKGKPKKAFSDDVLAILAPVCGAPQNFDPQTLIERTMIPMINEVVLCLEEGIIASAQEADMALVYGLGFPPFRGGVFRYLDTIGIANYVAMAEKYADLGALYQVPQLLKNMAQQGTSFYSAQQASAL
What is the function of this protein?
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle.  Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA.  It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
What are the official names of this protein?
Fatty acid oxidation complex subunit alpha.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
Protein: TXS4D_CUPSA
Sequence: FLAKNVAKKLVSHVAKKQLE
What are the official names of this protein?
Short cationic peptide-4d, SCP-4d, Short cationic peptide-4f, SCP-4f, Truncated variant of Cupiennin 4 family.
What is the protein family that this protein belongs to?
Belongs to the cationic peptide 04 (cupiennin) family. 04 subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: KUP_NITMU
Sequence: MTNQQMPSGHSLERQPLSLLCLAALGVVYGDIGTSPLYVMKTVFDPIHGLAVTESNVIGIISLIFWTIMIVVSLKYVTLILRADNHGEGGIMALLSLASSSVTDRPRLHNILFLIGAFGAALFFGDGVITPAISVLSAVEGLEVATPLLQPYVLPITVVVLIALFMLQQRGTGGIGALFGPVMVIWFVSLGLVGLINIAGAPQIVAAFNPMYAFAFCISNGWLAFIALGAVVLAVTGGEALYADMGHFGAKPIRLAWYGGVLPALTLNYLGQGALLLANPAAISNPFFLLFPSWALYGAVGLATAATVIASQSVISGVFSVTRQAIQLGFLPRMQIRHTSERKIGQIYIPFVNWTLLSVVLMAVLGFGSSSNLASAYGVAVTTTMVIETTLTFFVLRYVWNYPFLLGILVTAFFLAIDSAFFSATILKVAQGGWFPLVIGSVIFFIMITWSRGRQMLVDHLRSVAIPLQSFLESLIAHPPTRVAGTSVFLTANPDGVPHALLHNLAHNQVLHERVVFLTVTYQETPWVPVEQRISIKPLMENCYQITVRYGFKDEANLPYALELCEPHGLVFEPLRTSYFLSREIVVPSPGTGMSLWRERLFAAMVRNASNAAEYFKLPANRVLELGARVEI
What is the function of this protein?
Transport of potassium into the cell.  Likely operates as a K(+):H(+) symporter.
What are the official names of this protein?
Probable potassium transport system protein Kup.
What is the protein family that this protein belongs to?
Belongs to the HAK/KUP transporter (TC 2.A.72) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DEMA_BOVIN
Sequence: MERLQKQPLTSPGSVSSSRDSSVPGSPSSIVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRERSLSPKSTSPPPSPEVWAESRSPGTISQASAPRTAGTPRTSLPHFHHPETTRPDSNIYKKPPIYKQRAESTGGSPQSKHPIEDLIIESSKFPAAQPPDPNQPAKIETDYWPCPPSLAVVETEWRKRKASRRGAEEEEEEEDDDSGEEMKALRERQREELSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHAGTSKSSSLPAYGRTTLSRLQSTDFSPSGSEAESPGLQNGEGQRGRMDRGNSLPCVLEQKIYPYEMLVVTNRGRTKLPPGVDRMRLERHLSAEDFSRVFSMSPEEFGKLALWKRNELKKKASLF
What is the function of this protein?
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization.  Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA).  Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane.  Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties.  Also plays a role as a modulator of actin dynamics in fibroblasts; acts as negative regulator of the RhoA activation pathway.  In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation.  Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration.  Acts as a tumor suppressor and inhibits malignant cell transformation (By similarity).
What are the official names of this protein?
Dematin, Dematin actin-binding protein, Erythrocyte membrane protein band 4.9.
What is the protein family that this protein belongs to?
Belongs to the villin/gelsolin family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane. Membrane. Endomembrane system. Cell projection. Note=Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane (By similarity).
Protein: PSIT1_PSICU
Sequence: MNPTTATDAHERTSLLSGRPQSAANSTAPYERQVQPSRKSQCFTPVTVITIITLIYRLATTMVITTNIRVLHTVACQLWYHVNDPDVFPGGNIPEKYCALPGVDKYYAIMVSMTTVIDGLGGILGTGIASYMSSRFGRKPVLMFLLSCTMIDHLAILTVQNVYGWKQLVTFGLIMIVETIGNENTTVFLVSMYVVDVTEAERRTAALSSITGWLVLGGALAYSIGGSITTFLHSNSAVYIVSFSVTGIVLTFTAFVLPESFPAEKRDLLRLERLAETRGHSQSWTQKIKAVATVALEPMELLKPTFNPITGKANWRLVYCALHSFIVTLADAYALPAMLIFFTTQYSYTPAQMGYVMTTYSVSSVFVLAIALPLFIRWFKPLYNNTQTKSVPDEGDGLRATDSGEAGVHTQEVVVSETSDRMDVHITVISWTIESLAYIVLGTVGSFYAQLLGRPLPLLALDLDAFQEFEA
What is the function of this protein?
Major facilitator-type transporter; part of the gene cluster that mediates the biosynthesis of psilocybin, a psychotropic tryptamine-derived natural product (PubMed:28763571).
What are the official names of this protein?
Major facilitator-type transporter psiT1, Psilocybin biosynthesis cluster transporter 1.
What is the protein family that this protein belongs to?
Belongs to the major facilitator superfamily. TCR/Tet family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CDO1_DANRE
Sequence: MEQTEVMKPETLEDLIKTLHQIFQSDSINVEEVQNLMESYQSNPQDWMKFAKFDQYRYTRNLVDEGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGQLKETLFDWPDRKLQSGMKPRGQSVLQENQCAYINDSLGLHRVENVSHTEPAVSLHLYSPPFQSCRTFDQRTGHHNTVKMTFWSKYGERTPYELSVSQENN
What is the function of this protein?
Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
What are the official names of this protein?
Cysteine dioxygenase type 1, Cysteine dioxygenase type I, CDO, CDO-I.
What is the protein family that this protein belongs to?
Belongs to the cysteine dioxygenase family.