Protein: EYS_DANRE
Sequence: MRNPKLAIIVFLLSCVIYGPVYSQVTCRRATSREWHTQPKNISVRWTLMENTCSSLTQCWSSFAETNGHFWTTGPYHFPQLCPLELQLGDLLFVSADGTLEQHGVQLIKVSKEEFDKCAILEPRKEQLVFASSINGTLQVESKWLMSGLNYFTIINRGSSHLCRFGLRIAVLVKPQLCQSSPLLRLCSGKGECRTTLKDDSFTCRCHKHFSGRYCENVDGCYEQPCLNGGTCLSEGSAYTDLPPYTCLCPAPFTGVNCSEIIGNQNCSKWCKEGACLKVSSTSYRCECFTGYTGTYCERKRLFCDSNPCRNDGRCEETANGYVCTCPGGFTGLNCETTAEADSYCKSSGCQLDEACATDKLNATCICVDPECLEQAEVCGTLPCLNGGICVVPNGQYHCRCRQGFSGKNCEEIIDFCKLLNINCLNEGLCLNRVGGYNCLCAPGWTGEFCQYLENACLAYPNRCLNGATCISMSQTTAPPHYMCTCLPGYTGPYCEAEVNECDSSPCQHQGTCTDFVGYYKCTCPSGYTGIDCEIDINSCWLPNATCPPETLCVDLPGDQLFKCHTPCPHYLQPCANGGHCVLHNITSYSCVCAPGWTGATCLVNINECVQHRCQNRATCVDEVGGYSCLCGHGYTGVHCELDFCSGHQCSEHAVCVDQQHNYTCRCMLGYEGTLCELETDECKSAPCTNNATCIDLVAGYQCLCAPGFKGRTCSESMNECWSRPCNNGGSCIDLVNDYICNCPLGFTGHDCSMPATGCTSNPCNTKGTSMCEEQQDGFKCVCHHGYTGLFCETSINHCVEGLCHHGSECVDLTKGFMCECLPGLRGRLCEVNIDDCLDKPCGALSICKDGINAYDCFCAPGFVGNNCEIEVNECLSQPCQNGASCSDELNSFSCLCLAGTTGSLCEINIDECQSSPCMNNGTCLDLSDGFKCICPSGFSGPECSMDINECVSYPCKNGGSCIDQPGNYYCRCLAPFKGLNCELLPCEAVNPCDNGAECVEEADLVLFPLGFQCRCRKGFTGPRCEVNIDECSSNPCLNGFCYDAVDGFYCLCNPGYAGVRCEQHINDCASNMCENNSTCVDLHLSYNCLCLPGWEGEYCQRETNECLSNPCKNNATCTDLLNAYRCVCPQGWTGLDCDEDVKECSSSPCLNGAHCVESDTPGEFSCTCPPFFTGPLCEQPYDPCELQRNPCLHNSTCRAQSDGTALCVCPVGFEGTRCEIDSDDCVSRPCQNRGICVDGVNSYSCFCEPGFSGLHCEEDINECASNPCQNQAVCQDLVNGFQCSCVPGYFGPHCNLDVNECDSSPCLHESVCINKPGGFACVCSAGFSGKWCELNVDECKSNPCRNNGSCIDGLNGYQCVCSRGFMGDHCERNTDECSSGPCVHGSCLDEIDAFSCQCEVGWTGHRCQININECEAHPCLNGGSCVDLLDKYACICADGFTGKNCDIDQNVCLQTSLNFSLCFNGGTCVDGPGVNFTCSCRPGFMGDFCEVEMNECCSEPCFNGAICQDLINGYQCHCRPGWTGLHCEDDINECLLQPCNQGMCIQNEPGHGYTCFCRPGFVGENCEYNYDDCLIQSCPETFSCKDGINNVSCVPVKTDTSSLPPISVVSWRSTDISTELQPTFAPVENLQHTEQPADASFGGYSGNSFLEFGGFEVAVPISVTVRFQTESMYGTLLYSASAKRSVFFIKLYISNGILQYDFLCNQKQGVQRINTAQWVADGNEHVVIFRQCLFPCVAEVTVSGVRTVRSAPGNYTSALRLQRTDHVFIGGLPRHRSPYKEAEPFHNYTGCIEIIEINKLRRFHMDHAIARNNVDNCRSQWHHEPPTSSTHSPTLLITVETPPGEWVRVLSPTQPAPVCPQGICLNGGTCRPVSLPSGASSFFCDCPLHFTGRLCEQDITVFSPRFDGNSFLELPSLTSLFQSDTYFPSRSSEDKRILYLTMKSRTPHGSLLYCREQDLGERFLHVFLQNARAVARLGCGAAHILTAVAAQNIRIDSLVAITVRYALPSQNNGQLCFIEIAADNGTANQQQKYMDEPVSEVVFGPTFLGGFPSVLELHHNSGNVSGFIGCIRELQMGSKELYVVGEAIRGQNIQNCDAAVCQHQPCRNGGTCISDAESWFCACPSLYSGKLCQFTACERNPCARGATCVPQTQLEAACLCPYGRQGLLCDEAINITRPKFSGLDEFGYSSYVAYPSIPSTGHFYEFHLKLTFANNASALRNNLILFSGQKGQGLSGDDFFALGVRNGRIVHKYNLGSGLATIISDRLNPRINIHTVHFGRYLKTGWLKVNGQKRRTGTSPGPLMGLNTFSQLYIGGYEEYTPELLPPGSRFQNSFQGCIFDMLFRTRQDGKFHALGGPDIRPLSGRNVGQCGVNPCSLVFCHNGGTCVDSGSSVYCQCVFGWKGALCSEKVSFCDAEHIPPPFCARGSTCVPLSDGYTCQCPLGSAGLHCQQAITISDPFFSGNQSSWMSFPPINIRHRTHVQLQFQTLSPEGILFYTAQHLSTHSGDFLSISLSAGFLQLRYNLGNQTIVLQSPKELDVTGVRWHTVKAGREGNSGFLIVDGESVTRNSSEGSTTLDVGANIFIGGISSLNTVSIDAVEKELVGFTGGIREVVVNGQELELTETGALDGANVGDWDGTACGYKVCKNGGHCHPSGDFSFTCICPSLWTGSRCQQSIQCLNNLCQHNSVCIHNSTSASYSCMCSLGWTGTHCDREVTLKTIRFIGNSYLKYKDPKYNSRNLMHTEVSLNFSTSAGDGLIFWMGKAESEDDDHLAVGLQDGYLKISVNLGERTALPLVYQNSFCCNYWNYLSITHNRTLIQVYVNEERVIFEDIDPFEQYVAVNYGGVIYLGGFELNRDVASVTSGVFTKGFEGSIKDVFLYQDTKQLQFLQTCEGFNVYQGEE
What is the function of this protein?
Required to maintain the integrity of photoreceptor cells (PubMed:27737822, PubMed:28378834, PubMed:30052645).  Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (PubMed:27737822).
What are the official names of this protein?
Protein eyes shut homolog.
What is the protein family that this protein belongs to?
Belongs to the EYS family.
What are the subcellular locations of this protein?
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822, PubMed:30052645). May localize to the cilium axoneme (By similarity). May also be expressed in the interphotoreceptor extracellular matrix (By similarity). Unlike the primate ortholog, does not appear to be expressed in the photoreceptor outer segment (PubMed:27737822).