PharMolix/UniProtQA huggingface dataset:
Protein: WTPC_METJA
Sequence: MLKVNNLSKIWKDFKLKNVSFEIDREYCVILGPSGAGKSVLIKCIAGILKPDSGRIILNGEDITNLPPEKRNVGYVPQNYALFPNKNVYKNIAYGLIIKKVNKLEIDRKVKEIAEFLNISHLLNRDVKTLSGGEQQRVALARALILNPSILLLDEPTSAVDIKIKESIISELKKIKHIPVLHITHDLAEARTLGEKVGIFMNGELIAFGDKSILKKPKNKKVAEFLGFNIIDDKAIAPEDVIIKDGNGGEVVNIIDYGKYKKVFVKYNGYIIKAFTERDLNIGDNVGLEFREQTKLT
What is the function of this protein?
Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Molybdate/tungstate import ATP-binding protein WtpC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RF1_STAAR
Sequence: MFDQLDIVEERYEQLNELLSDPDVVNDSDKLRKYSKEQADLQKTVDVYRNYKAKKEELADIEEMLSETDDKEEVEMLKEESSGIKAELPNLEEELKILLIPKDPNDDKDVIVEIRAAAGGDEAAIFAGDLMRMYSKYAESQGFKTEIVEASESDHGGYKEISFSVSGNGAYSKLKFENGAHRVQRVPETESGGRIHTSTATVAVLPEVEDVEIEIRNEDLKIDTYRSSGAGGQHVNTTDSAVRITHLPTGVIATSSEKSQIQNREKAMKVLKARLYDMKVQEEQQKYASQRKSAVGTGDRSERIRTYNYPQSRVTDHRIGLTLQKLGQIMEGHLEEIIDALTLSEQTDKLKELNNGEL
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ROT1_COCIM
Sequence: MVLIVALLVFFCFLTAVPAALDPKLTGTWATKSRKVVTGPAFYDPAEDRFQEPENTGISYSFTEDGYFEEAYFRAIPNPTKPSCASAMMQFQHGKYSVESNGSLVLTPFAVDGRQLISSPCKSEGSMYFRFNQTEVFKRYEVLTDPFHNVKRLNLYQFDGTPMNPMFLVFDPPQMLPTETLNPTAQASATGRSKAKRGLPYGSGMASSRNKRPSTQVGGLTDPDKWWWAGVMMTLVGGVAFLYSESPWKDW
What is the function of this protein?
Required for normal levels of the cell wall 1,6-beta-glucan.  Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity).
What are the official names of this protein?
Protein ROT1.
What is the protein family that this protein belongs to?
Belongs to the ROT1 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: SELA_ECOL5
Sequence: MTTETRSLYSQLPAIDRLLRDSSFLSLRDTYGHTRVVELLRQMLDEAREVIRDSQTLPAWCENWAQEVDARLTKEAQSALRPVINLTGTVLHTNLGRALQAEAAVEAVAQAMRSPVTLEYDLDDAGRGHRDRALAQLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLMKVHTSNYSIQGFTKAIDEAELVALGKELDVPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQAGIIVGKKEMIARLQSHPLKRALRADKMTLAALEATLRLYLHPEALSEKLPTLRLLTRSAEVIQIQAQRLQAPLAAHYGAEFAVQVMPCLSQIGSGSLPVDRLPSAALTFTPHDGRGSHLESLAARWRELPVPVIGRIYDGRLWLDLRCLEDEQRFLEMLLK
What is the function of this protein?
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
What are the official names of this protein?
L-seryl-tRNA(Sec) selenium transferase, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase.
What is the protein family that this protein belongs to?
Belongs to the SelA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LAEA_ASPFS
Sequence: MFLNGQGGQRPPTVASPPLNVRGSISSDFNALGRSRNNSDAMDIYTITDRGPAAERDPAAGRWHANGSPSINSTSSKNPDRYPCYQENGRTYHGYRKGIYMLPCDEQEQDRLDIFHKLFTVARVSDGLIYAPHPTNGRFLDLGCGTGIWAIDVANKYPEAFVVGVDLAPIQPPNHPRNCDFYAPFDFESLWALGEDSWDLIHMQMGSGSVASWPNLYRRIYSHLRPGAWFEQVEIDFEPRCDDRSLEGLAIRQWYQLLKQATEETMRPVAHNSRETIRNLQEAGFTEIDHQMVGLPLNPWHQDEHERRVARWYNLAISESIETMSLAPFSRVFGWPIERIKQIAADVKSEAFNKEIHTYNILHIYQARKPLAN
What is the function of this protein?
Methyltransferase that performs automethylation (By similarity).  No other methyl-accepting substrate has been identified yet (By similarity).  Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:26466873).  Controls the expression of the cyclopiazonic acid (CPA) gene clusters (PubMed:26466873).  Regulates also pigmentation and conidial head morphology (PubMed:26466873).
What are the official names of this protein?
Secondary metabolism regulator laeA, Methyltransferase laeA, Velvet complex subunit laeA.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. LaeA methyltransferase family.
What are the subcellular locations of this protein?
Nucleus.
Protein: TMM70_HUMAN
Sequence: MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAARLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVITPVLLHFITKGYVIRLYHEATTDTYKAITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDKEEFILYMEETSEEKRHKDDK
What is the function of this protein?
Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929).  Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072).  In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929).
What are the official names of this protein?
Transmembrane protein 70, mitochondrial.
What is the protein family that this protein belongs to?
Belongs to the TMEM70 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein. Note=Mostly located within the inner cristae membrane.
Protein: MATK_PAEMR
Sequence: MEKSQGYLELDKSWRHNFLYPLIFQEYIYALAHEQGLNRSILLENTDHDNKYSSLIVKRLITLIHQQNHFLIFDNDSNQNPFWKHNNNLYSQTISEGFVIIVEIPFSPRFVDSLEEKKKILKSNNLRSIHSIFPFLEDQILHLNFVANILIPYPIHLEIVVQSLRYRVKDASSLHLLRFFLFTLNKSISSFSKRNQRFFLFLYNSHVYEYESTFLFLRNKTSHLRSTSSGAFLERIFFYGKIKHLIEVFANDFQAILWLFKDPFMHYVRYQGKSILASKRTSLRMNKWKYYLVNFWQCQFYVWSQPGRVSINQLSNHSLDFLGYLSSVRRNPLAVRSQMLENSFLTDNAIKKFDIIVLLISLIGSLAKAKFCNVLGHPLSKPARADSSDSDIIERFVRICRNLSHYHSGSSKKKSLYRIKYILRLSCARTLARKHKTTVRSFLKRLGSELLEEFLTEDGQVISLIFPRTSSTSWRLYRGGIWYLDITCINDLANHE
What is the function of this protein?
Usually encoded in the trnK tRNA gene intron.  Probably assists in splicing its own and other chloroplast group II introns.
What are the official names of this protein?
Maturase K, Intron maturase.
What is the protein family that this protein belongs to?
Belongs to the intron maturase 2 family. MatK subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AMP1_SCOMU
Sequence: FLPKMSTKLRVPYRRGTKDYH
What is the function of this protein?
Antimicrobial peptide against both Gram-positive, -negative and yeast.  Also induces histamine release by mast cells and shows moderate hemolytic activities against both human and rabbit red cells.
What are the official names of this protein?
Antimicrobial peptide scolopin-1.
What are the subcellular locations of this protein?
Secreted.
Protein: CCM1_VANPO
Sequence: MLRYTRNYRLHNVASSLILKRTAIIPSLQGLRRGNFSQDDTTNLNNKKRRKRKVTSISLDDLNSVNLKKVNTKELEFKVRQLKEFTKNLKAQIKRSESRNEKRETEDDIDLEEINKDADSVFENLSNHERRKNHKVQNHLGIPIGNSQNQSTNLSSLILGSSLEQAQKFLPSTLVTRLNDNNLVLKCLTDKTRQNWNPIIKSISKNREGLNGIGKNKLNSTLLSSVKGLYFDNIERLDKMLLEYVDNDITKFTTEMYLSLFENLSNIKLTDPNMSNEVIVKMKELLERYDEALIKGTDTKMTQYILNNGIKFASKLNNHEHMEYFLTKFKGYGIIPNRINYTTVLQYYIRMGISKKSWDIFDTMKFLSKEHAPDLIAYNSVLTLCSRDKDYSKALDIYNEMVNSGINPGTSTRTIMAKILAIASRDSFTSEGKSESLRLLGWKFIHEIIETTGSKLSHKSLESMIALAAYDGDVGMSRALYHCYVTTKYRNVVQNWVGKRDYVKIWKSVLDPRMLNYLFLAYSNYNSNKLPLLLGYEQGILLRRNIINSVDYSGRSEFDDDLGVLLPFLPVTEIKHNWELLAESRAIWHFNLEYGGSTSLRSTSESIVDKSTIMTAVENSKTIDDFKWNIFSKIHELKSQTINTDVLNSIVLNTYLTIPIKLHDKKEFVLRLKEFTFQQHDFDSKIESFYLESNNKMVEDNDKNSSSPSTSEDTSIELAEDPNDLLAHYILSLKHKILANCSTYELTMKAASKFNDIKLATEAWEERGKFRKSSSFQKLAQNNRMESDTKFAELMVAFFSSQKMYTDALHVVMSSKRYIDWKYPMVKNLHRGLLEIEDSRSIDILLDIVNRKSKVQTIEETISSLTL
What is the function of this protein?
RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts.  Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity).
What are the official names of this protein?
Mitochondrial group I intron splicing factor CCM1.
What is the protein family that this protein belongs to?
Belongs to the CCM1 family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: XAC4_XYLVO
Sequence: GVLSLLKKFTMILKHVHVN
What is the function of this protein?
Antimicrobial and mast cell degranulating peptide which probably acts by forming pores in membranes (By similarity).  Active against both Gram-negative and Gram-positive bacterial strains as well as against yeasts (By similarity).  Has little hemolytic activity (By similarity).  In the context of inflammation and cancer tests, is weakly cytotoxic to normal cells, induces calcium signaling but does not impact cAMP production (PubMed:36548715).  In addition, prevents LPS-induced nitric oxid (NO) synthesis but does not affect the IP3 signaling and pro-inflammatory activation of endothelial cells (PubMed:36548715).  Also shows significant antiproliferative activity on the breast cancer cell line MDA-MB-231 (PubMed:36548715).
What are the official names of this protein?
Antimicrobial peptide Xac-4, Xac4.
What is the protein family that this protein belongs to?
Belongs to the xylopin-like family.
Protein: CHSA_EMENI
Sequence: MDCQNGRRANRTVRFARTAESRYPERYSYEYDPEETLSRAAPSMRNAPTIPPPTASGADEMRYTASRPASPARPWSPTRAADWVRPPSAAASYYERADINGSPRPGTPSSRYGGSPRRPLPPAPLFSKPGTTTQDTKIDIGDGEEDPFGGGGRTISSRHGPQGSVQSFTSESTFIADETDLEKVDLDEYEEESNETKSMVDPNLHYGPAPEKQSRRGVRNAQMAKKEVQLVNGELILECKIPTILHSFLPRRDDREFTHMRYTAVTCDPDDFTQRGYKLRQQIGRTMRETELFICITMYNEDETHFTRTMHGVMQNISHFCSRSKSRTWGKDGWKKIVVCIISDGRKKVHPRTLNALAALGVYQEGIAKNVVNQKQVNAHVYEYTTQVSLDSDLKFKGAEKGIVPCQVIFCLKEHNQKKLNSHRWFFNAFGRALQPNICILLDVGTRPEPTALYHLWKAFDQDSNVAGAAGEIKASKGKNMLGLLNPLVASQNFEYKMSNILDKPLESVFGYITVLPGALSAYRFFALQNDAEGNGPLNQYFKGETLHGKDADVFTANMYLAEDRILCWELVAKREERWVLRFVKSAVGETDVPDSIPEFISQRRRWLNGAFFAAVYSIVNVKQLWKTDHSLARKILLQIESVYQLLQLIFTYFGLANFYLAFFFIAGSLTDEKIDPFGHNMGKYIFIVLRYACVLVMCLQFIFSMGNRPQGAKKLYLSSMIVYSIVMAYTAFCTLYLIVLELMAKTGHDVPITMSDTLFVNIVVSLLSTVGLYFFTSFMYLDPWHMFTSSAQYFALLPSYICTLQCYAFCNTHDVTWGTKGDNTINTDLGTARIINGSIVEVEMPSEQLDIDSGYDAALRNLRDRLEVPDPGVSESQQQEDYYRAVRTYMVSVWMVANVVLAMAVSEVYGVGSSGTNVYLAIILWSVAVLAIIRAIGSTAYAVLYLIQKLVEGKAKFQAGNIASANASAAGSSLGTKSNVSYGSKGLNMTDRINETKWAISRGMQKAMFWKK
What is the function of this protein?
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
What are the official names of this protein?
Chitin synthase A, Chitin-UDP acetyl-glucosaminyl transferase A, Class-II chitin synthase A.
What is the protein family that this protein belongs to?
Belongs to the chitin synthase family. Class II subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RNC_CLOB8
Sequence: MNRYTLKEIEENLGVFFNNHTLLKTALTHSSFGNQFKDAEYNERLEFLGDSVLQLCITEYLFNNYKHKTEGELTKIRSLIVCENSLYEIAKKINLGSYIRMSKGEEITGGRERISIQADAVEAIIAAVYLDKGIGFVRDFILLHFEEIINKAINNEIVLDFKTKLQELLQKDGEVVIQYELTKFEGPPHRRKFFTNVVIDKKLMGEGSGYSKKEAEQNAAKQALDILEGKHE
What is the function of this protein?
Digests double-stranded RNA.  Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S).  Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon.  Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
What are the official names of this protein?
Ribonuclease 3, Ribonuclease III, RNase III.
What is the protein family that this protein belongs to?
Belongs to the ribonuclease III family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DGKZ_RAT
Sequence: MEPRDPSPEARSSDSESASASSSGSERDADPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESERQIRSTVDWSESAAYGEHIWFETNVSGDFCYVGEQYCVAKMLPKSAPRRKCAACKIVVHTPCIGQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPMCHPLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSLQGDAALPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDHQSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
What is the function of this protein?
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids.  Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes.  Also plays an important role in the biosynthesis of complex lipids.  Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species.  Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity).  The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (By similarity).  By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity).  Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (By similarity).  Regulates RASGRP1 activity (By similarity).
What are the official names of this protein?
Diacylglycerol kinase zeta, DAG kinase zeta, 104 kDa diacylglycerol kinase, DGK-IV, Diglyceride kinase zeta, DGK-zeta.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic diacylglycerol kinase family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium.
Protein: GPDA_XANOM
Sequence: MSDSTHKIAVIGAGSWGTALAALLARHGHPTVLWGRDAAMVDTIDRTHENARYLPGIALPDSLRATTDLQAAVADAAWILVVVPSHAFTETIRLIAPLRPACPGVAWATKGFEPGSGRFLHEVARDILGPSVPLAVVTGPSFAKEVTLGLPTAITVHGDDATFAQAVADAMHGPTFRAYTGDDMVGAELGGAMKNVLAVATGVADGMQLGLNARAGLITRGLNEMLRLAAAIGARPETLMGLAGLGDLVLTCTGDLSRNRRLGLALGRGQSLNDAIRQIGQVVESVQMADEVMRQAEHHGIELPISNAVRAVLHGEITPEAGLKELLARERKPEYPQTLFT
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YPEA_SALPA
Sequence: MEIRVFRQEDFEEVITLWERCDLLRPWNDPEMDIERKVNHDVSLFLVAEVSGEVVGTVMGGYDGHRGSAYYLGVHPEFRGRGIANALLNRLEKKLIARGCPKIQIMVRDDNDVVLGMYERLGYEHSDALSLGKRLIEDEEY
What are the official names of this protein?
Acetyltransferase YpeA.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. YpeA subfamily.
Protein: DAPD_PELUB
Sequence: MKEFESIINTAWENKDSINGQSDKSILDAINQTIELVDKGELRVAEKNGNEWVVNQWVKKAIMLSFRTHDMDSLSGPYSSWYDKSHLLKGKTANWTKEDHIKAGFRMVPNSPVRKGSFIGKNAVLMPCFVNIGAYVDEGTMVDTWASVGSCAQIGKNCHISGGAGIGGVLEPMQANPTIIEDNCFIGARSEIVEGVIVGEGSVLSMGVFIGQSTKIVYRETGEVIYGKIPPYSVIVPGSIPSKDGKGPALYCAVIIKQVDEKTRSKTSINDLLRD
What are the official names of this protein?
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, Tetrahydrodipicolinate N-succinyltransferase, THDP succinyltransferase, THP succinyltransferase, Tetrahydropicolinate succinylase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PPE68_MYCTU
Sequence: MLWHAMPPELNTARLMAGAGPAPMLAAAAGWQTLSAALDAQAVELTARLNSLGEAWTGGGSDKALAAATPMVVWLQTASTQAKTRAMQATAQAAAYTQAMATTPSLPEIAANHITQAVLTATNFFGINTIPIALTEMDYFIRMWNQAALAMEVYQAETAVNTLFEKLEPMASILDPGASQSTTNPIFGMPSPGSSTPVGQLPPAATQTLGQLGEMSGPMQQLTQPLQQVTSLFSQVGGTGGGNPADEEAAQMGLLGTSPLSNHPLAGGSGPSAGAGLLRAESLPGAGGSLTRTPLMSQLIEKPVAPSVMPAAAAGSSATGGAAPVGAGAMGQGAQSGGSTRPGLVAPAPLAQEREEDDEDDWDEEDDW
What is the function of this protein?
Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M. tuberculosis infection.  Together with PE35, stimulates the secretion of IL-10 and MCP-1 from human macrophages, via the interaction with human Toll-like receptor 2 (TLR2) (PubMed:24467650).  Stimulates high levels of gamma interferon secretion in peripheral blood mononuclear cells isolated from tuberculosis patients, as well as from healthy tuberculin purified protein derivative-positive donors.  Does not interfere with the secretion and immunogenicity of EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:14573626, PubMed:15039340).
What are the official names of this protein?
PPE family immunomodulator PPE68.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial PPE family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell membrane. Cell surface. Note=Detected predominantly in the membrane and cell wall fractions.
Protein: AAXB_CHLTA
Sequence: MPYGTRYPTLAFHTGGVGESDDGMPPQPFETFCYDSALLQAKIENFNIVPYTSVLPKELFGNILPVDQCTKFFKHGAVLEVIMAGRGATVTDGTQAIATGVGICWGKDKNGELIRGWAVEYVEFFPTWIDDEIAESHAKMWLKKSLQHELDLRSISKHSEFQYFHNYINIIKKFGFCLTALGFLNFENAAPAVIQ
What is the function of this protein?
Part of the AaxABC system, catalyzes the decarboxylation of L-arginine.  The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response (By similarity).
What are the official names of this protein?
Pyruvoyl-dependent arginine decarboxylase AaxB, PvlArgDC, Biodegradative arginine decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the pyruvoyl-dependent arginine decarboxylase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NU160_MOUSE
Sequence: MAAAGSLERSFVELSGAERERPRHFREFTVCDIGTASAAFGTVKYSESAGGFYYVESGKLFSITRNRFIHWKTSGDTLELVEESLDLNLLNNAVRLKFQNYNILPGGVHVSETQNHVIILILTNQTVHRLILPHPSRMYRSELVTESQMQSIFTDIGKVDFRDPCNSQLIPSVPGLSPGSTTSAAWLSSDGEALFALPSASGGIFVLKLPPYDVPGIASVVELKQSSVMQRLLTGWMPTAIRGDHGPSDRALSLAVHCVEHDAFIFALCQDHKLRMWSYKDQMCLMVADMLEYVPVNKDLRLTAGTGHKLRLAYSPSMGLYLGIYMHAPKRGQFCVFQLVSTENNRYSLDHISSLFTSQETLVDFALTSTDIWALWHDAENQTIVKYINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLRSLFTPGHFINAALCKALQIFCRGTERNLDLSWNELKKEITLAVENELQGSVTEYEFSQDEFRTLQQEFWCKFYACVLQYQEALSHPLALHLNPVTNMVCLLKKGYLSFLVPSSLVDHLYLLPDEHLLTEDETTISDDADVARDVLCLIKCLRMIGESVTMDMAVLMETSCYNLQSPEKAAEHILEDLITIDVENVMEDICSKLQEIRNPVHAIGLLIREMDYETEVEMEKGFDPAQPLNVRMNLSQLYGSSTAGYIVCRGVYKIASTRFLICRDLLILQQLLTRLGDAVILGAGQLFQAQQDLLHRTAPLLLSYYLIKWASQCLATDVPVDTLESNLQHLSVLELTDSGALMANKLVSSPQTIMELFFQEVARKQIISHLFSQPKAPLSQTGLNWPEMITAVTGYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEVQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPKLQYYDKVLRLLDVVGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEALTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAAINCLRLIRPEYAWIVQPASGAVSDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKEYSLARIRLTLARHDPSVIAIAGSSSAKEMSALLVQAGLFDTAISLCQTFTLPLTPVFEGLAFKCIKLQFGGEAAQGEAWSWLATNQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVPLPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALGENSANSHNIILSQKILDKLEDYQQKVDKATRDLLYRRDL
What is the function of this protein?
Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705).  Involved in poly(A)+ RNA transport (PubMed:11684705).
What are the official names of this protein?
Nuclear pore complex protein Nup160, 160 kDa nucleoporin, Gene trap locus 1-13 protein, GTL-13, Nucleoporin Nup160.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex.
Protein: ACCD_GOSHI
Sequence: MEKSWFNLILSKGELEYRCGLSKSMDSRLGPVENTTVNEDPTRNDTDKNIHDCSDSSSYYSKVDHLVDVKDIRNFISDDTFLIRDSNQDRYSIYFDSENQIFELNNDHSFLSELESFFYSYHNSSYMNNGSKNDEPHYHFNLYDNDTNCGWNNHINSCIDSYLRSQICIDSSILSGSDNSNDNYISNYICGEGGNSSEGKNFDIITRENGNDLTLKESSNDLDLYKDLWVQCECENCYGVNYKKSLNSKMNICEQCGYHLKMRSSDRIELSIDPGTWGPMDEDMISLDPIEFQSEEELYKDRIDFYQRKTGLTEAIQTGTGQLNGIPIAIGVMDFQFMGGSMGSVVGEKITRLIEYATNNFLPLILVCASGGARMQEGSLSLMQMAKISSALYDYQSNKKLFYVSILTSPTTGGVTASFGMLGDIIIAEPNAYIAFAGKRVIEQTLNKTIPEGSQAAEYLFHKGLFDPIVPRNPLKGVLSELVQLHGFFPLNQNSIK
What is the function of this protein?
Component of the acetyl coenzyme A carboxylase (ACC) complex.  Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
What are the official names of this protein?
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic, ACCase subunit beta, Acetyl-CoA carboxylase carboxyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the AccD/PCCB family.
What are the subcellular locations of this protein?
Plastid, chloroplast stroma.
Protein: RL4_CYTH3
Sequence: MELSLLNIKGKDTGKKVVLSDDIFAVEPNNHAIYLDVKQYLAHQRQGTHKAKERAEVSFSTKKLKKQKGTGGARAGSRKSPIFVGGGTIFGPRPRTYGFKVNKKVKDLARKSAFSHKLKESNVTVLENFTLNAPKTKDYLAILKDLSLDTKKTLFVIADIDKNIILSSRNLKKAKVVSVDQINTYDLVNADKVVISEGSVSKIEALLN
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: RECX_YERPP
Sequence: MNDQLSRAMRLLSQRDHSESELRRKLAAPPFSAKGNWGKRSGAKSSDVVESNLVESNPVESNLAESNAIEESDPQVIEQVIDYCYQHNWLDDSRFAASYINSRSRKGYGVQRIRSELMQKGVDKERILAAFENSEIDWCQLAKEVAQRKFSETLPVEWKEKAKVQRYLLYRGFFQEEIQSIYTDSVE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROB_CHLAB
Sequence: MIENLISHPHHIKLVGDFFNKKLFSSISTDHPLVILTDVQVAKEILPPIVDFIHSLDYTVVPLSFPSGEKNKTWETFISLQNQLIDHDIPLGSTMIGIGGGVVLDMVGFLASTYCRGIPLFLVPTTMTAMIDACIGGKNGINLRGLKNRLGTFYLPQDVWICPEFLSTLPKKEWLYGISEAIKHGCIADASIWEFLHNYGDMLFSSREILSEFIKRNCLVKAAIVAKDPHDQHLRKILNFGHTIAHAIETLSQGCLPHGLAVSVGMMIETKISLESGIMKNPALLEQLHHLSKRFHLPTTLEELRDLIPQHLHHEFYDPENIIHALGYDKKNLSKKAIRMVMMEDAGKATSCNGIYCTVPKMAILYEILKSECYAMCNN
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL19_STRS2
Sequence: MNPLIQSLTEGQLRTDIPSFRPGDTVRVHAKVVEGNRERIQIFEGVVISRKGQGISEMYTVRKISGGVGVERTFPIHTPRVDKIEVVRYGKVRRAKLYYLRALQGKAARIKEIRR
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.