PharMolix/UniProtQA huggingface dataset:
Protein: BST18_CAEEL
Sequence: MTVSYNQSVATSRPWTFLALIFRWRGSVWSAIWIQYSVWLGLYFLVSAIYRFILSAYQQQIFVRLVDYVNSRMSYVPLDWMLGFFIAGVLRRFWYLYDIIGFIDNIACSTATYIRGDSERAKQYRRNIIRYCELTQVLIFRDLSMKARKRFPTLDTVAAAGFMMPHEKANFDLIQYNYNKYFLPFNWAWALVYNARKEGLIEGDYYVTVISEDIKKFRTGLAWVCNYDWVPLPIIYPTIVCLAVHMYFFVGILARQYVKGSEIDPDMIDLVFPFMTSIQFVFYMGWLKVGEGLLNPWGEDPDDFETNMLIDRNLAMGLKIVDEGYDKTPRLEKDAFWDDTWVPLYSEASAHEKRYHQRQGSLAHIKIGRSVSQVRMVPRDGRRASIVKERIVNVKPGSGIGDILRPSSLLNLMKHASSSRSLERQRSPGSFRMETLTPGSPTNTPIEPIDKIDKKK
What is the function of this protein?
Forms chloride channels.
What are the official names of this protein?
Bestrophin homolog 18.
What is the protein family that this protein belongs to?
Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: MA2B1_MOUSE
Sequence: MGTGPLTSGVRAGGGNTGWLWMSSCNLGSPVLPISFLFWLLLAAPGARAAGYKTCPPTKPGMLNVHLLPHTHDDVGWLKTVDQYYYGILSDVQHASVQYILDSVVSSLLEKPTRRFIYVEMAFFSRWWKQQTSATQDAVRNLVRQGRLEFVNGGWVMNDEAATHYGAIVDQMTLGLRFLQDTFGSDGLPRVAWHIDPFGHSREQASLFAQMGFDGFFLGRIDYQDKLNRKKKLRMEELWRASDSLEPPAADLFTGVLPNNYNPPKYLCWDVLCTDPPVVDNPRSPEFNAKTLVNYFLKLASSQKGFYRTNHTVMTMGSDFHYENANMWFKNMDKLIRLVNAQQVNGSLVHVLYSTPTCYLWELNKANLTWTVKEDDFFPYADGPHMFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGPEANVGPYGSGDSAPLQEAMAVLQHHDAVSGTARQNVVNDYARQLAAGWGPCEVLVSNALARLSHYKQNFSFCRELNISICPVSQTSERFQVTLYNPLGRKVDQMVRLPVYEGNFIVKDPHDKNISSNVVMVPSYYSETYQWELLFPASVPALGFSTYSVAKMSDLNHQAHNLLSRPRKHKSHHVLVIENKYMRATFDSGTGLLMKIENLEQNLSLPVSQGFFWYNASVGDEESSQASGAYIFRPNVGKPIPVSRWAQISLVKTALVQEVHQNFSAWCSQVIRLYKGQRHLELEWTVGPIPVRDDWGKEVISRFDTPMKTKGQFFTDSNGREILKRRDDYRPTWTLNQTEPVAGNYYPVNTRIYITDGQMQLTVLTDRSQGGSSLQDGSLELMVHRRLLVDDDRGVSEPLLETDTGDKVRGRHLVLLSSVSDAAARHRLLAEQEVLAPQVVLSLGGSSPYHSRATPKTQFSGLRQELPPQVHLLTLARWGPKMLLLRLEHQFALKEDSDRNLSSPVTLNVQNLFQTFTINYLQETTLAANQPLSRASRLKWMTNTGPTSYPEPSKLDPTSVTLKPMEIRTFLASVQWQEHRPA
What is the function of this protein?
Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.
What are the official names of this protein?
Lysosomal alpha-mannosidase, Laman, Lysosomal acid alpha-mannosidase, Mannosidase alpha class 2B member 1, Mannosidase alpha-B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 38 family.
What are the subcellular locations of this protein?
Lysosome.
Protein: AROC_MYCBP
Sequence: MLRWITAGESHGRALVAVVEGMVAGVHVTSADIADQLARRRLGYGRGARMTFERDAVTVLSGIRHGSTLGGPIAIEIGNTEWPKWETVMAADPVDPAELADVARNAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTVARAFLRQALGVEVLSHVISIGASAPYEGPPPRAEDLPAIDASPVRAYDKAAEADMIAQIEAAKKDGDTLGGVVEAVALGLPVGLGSFTSGDHRLDSQLAAAVMGIQAIKGVEIGDGFQTARRRGSRAHDEMYPGPDGVVRSTNRAGGLEGGMTNGQPLRVRAAMKPISTVPRALATVDLATGDEAVAIHQRSDVCAVPAAGVVVETMVALVLARAALEKFGGDSLAETQRNIAAYQRSVADREAPAARVSG
What is the function of this protein?
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis.  This reaction introduces a second double bond into the aromatic ring system.
What are the official names of this protein?
Chorismate synthase, CS, 5-enolpyruvylshikimate-3-phosphate phospholyase.
What is the protein family that this protein belongs to?
Belongs to the chorismate synthase family.
Protein: RL3_MYCBT
Sequence: MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAEIFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ACT1_BOMMO
Sequence: MCDDDVRALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGLMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETVYNSIMKCDVDIRKDLYANTVMSGGTTMYPGIADRMQKEITALAPSTIKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPGIVHRKCF
What is the function of this protein?
Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.
What are the official names of this protein?
Actin, muscle-type A1.
What is the protein family that this protein belongs to?
Belongs to the actin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: AMPA_ESCF3
Sequence: MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSSDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LY6I_MOUSE
Sequence: MDTSHAIKSCVLILLVTLLCAERAQGLECYQCYGVPFETSCPSFTCPYPDGFCVAQEEEFIANSQRKKVKSRSCHPFCPDEIEKKFILDPNTKMNISCCQEDLCNAAVPTGGSSWTTAGVLLFSLGSVLLQTLM
What are the official names of this protein?
Lymphocyte antigen 6I, Ly-6I, Lymphocyte antigen 6M, Ly-6M.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI- anchor.
Protein: MTLD_ASPFC
Sequence: MGKKAIQFGGGNIGRGFVAEFLHEAGYEVVFIDVVDKIIDALKSTPSYEVTEVSEEGEKTKTITNYRAINSKTNEEDVVKEIGTADVVTCAVGPNVLKFIAPVIAKGIDARTASKPVAVIACENAIGATDTLRGFIEQNTDKDRLSSMSERARFANSAIDRIVPNQPPNAGLNVRIEKFYEWTVEQTPFGEFGHPDIPAIHWVDDLKPYIERKLFTVNTGHATTAYYGHMRGKKMIADALADAEIRQIVHKVLEQTAKLITTKHEITEQEQNEYVDTIVKRMSNPFLEDNVERVGRAPLRKLSRNERFIGPASQLAEKGLPFDALLGSIEMALRFQNVPGDEESAELAKILKEMSAEEATGKLTGLEKHHPLYEPVQNVIAKVQKDSK
What is the function of this protein?
Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase, M1PDH, MPD, MPDH.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: VPS51_ARATH
Sequence: MATEAAPMDEKAKRMRDLLSSFYAPDPSISTSGSSINASFDNINSTSFDADQYMDLMIKKSNLEVLLQRHVQMAAEIKNLDTDLQMLVYENYNKFISATDTIKRMKSNIFGMEGNMDQLLQKIMSVQSKSDGVNTSLFEKREHIEKLHRTRNLLRKVQFIYDLPARLQKCIKSEAYGDAVRFYTGAMPILKVYGDTSFQDCRRASEEAIEIIIKNLQTKLFSDSESIQARAEAAVLLKQLDVPVDSLKAKLLEKLEQSLDGLQIKPEEASTLVEDDDSSNDTESNDQHPAKIHEDAVRGFSEAIRAYREIFPDSEERLFKLARALTAMHFEYMELYIKKRVSAADFLGIFRIVWEDVVLMDEVLPEAALSDLSAEAAQVTLKQFVARMFSHLQQDISDTLLKFDINQKEAVEGELLKVVLEASQKAVLQGTTNIFQDFRQLLDEKTGIFIKMKDLISGWIQKGSQDFFRSLEAQFLVLSGKTSSSNDIEGKSSDKIHAGLILVLAQLSVFIEQKVIPRVTEEIAASFSGGNSQAFENGPAFIPGELCRVFHAASEKLLQHYIDTRTQKVSVLLRKRFKTPNWVKHKEPREVHMYVDMFLHELEEVGKEVKQVLPQGTFRKHKRTDSNGSNTTTSSRSNTLHNDKMARSNSQRARSQLFETHLAKLFKQKVEIFTKVEFTQESVVTTTVKLCLKSLQEYVRLQTFNRSGFQQIQLDIQFLKAPLKEAVEDEAAIDFLLDEVIVAASERCLDVIPLEPPILDKLIQAKLAKSKEHNNNTVSS
What is the function of this protein?
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).  The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy.  VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.  Acts as component of the EARP complex that is involved in endocytic recycling.  The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (By similarity).  Required for vacuolar targeting and cellular trafficking.  Involved in the regulation of vascular tissue patterning, probably by regulating PIN1 expression pattern, thus modulating auxin flux.  Important to prevent PIN1 accumulation within margin cells, possibly by targeting PIN1 to the lytic vacuole.  Regulates PIN1 and ATHB8 expression pattern in secondary veins (PubMed:24757006).
What are the official names of this protein?
Vacuolar protein sorting-associated protein 51 homolog, Protein UNHINGED.
What is the protein family that this protein belongs to?
Belongs to the VPS51 family.
What are the subcellular locations of this protein?
Golgi apparatus, trans-Golgi network. Recycling endosome. Prevacuolar compartment. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.
Protein: LSM5_HUMAN
Sequence: MAANATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEITPEGRRITKLDQILLNGNNITMLVPGGEGPEV
What is the function of this protein?
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).  The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).
What are the official names of this protein?
U6 snRNA-associated Sm-like protein LSm5.
What is the protein family that this protein belongs to?
Belongs to the snRNP Sm proteins family.
What are the subcellular locations of this protein?
Nucleus.
Protein: CH60_AERS4
Sequence: MAAKEVKFGNEARIKMLEGVNILADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVIAAVAELQVLSQPCADNNAIAQVGTISANSDEKVGRLIAEAMDKVGRDGVITVEDGQGLDDELAVVEGMQFDRGYLSPYFVNKPETGAVELDDPFILLVDKKVSNIREMLPVLEGVAKAGKPLLIVAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAMLTGGTVISEEVGMELEKATLEDLGRAKRIVITKENTTIIDGVGDAALIESRVAQIRQQIEETSSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVDDALHATRAAVEEGVVAGGGVALVRVAAKLAGLRGDNEDQNVGIKVALRAMEAPLRQIVINAGEEASVIANAVKNGEGNFGYNAYTEQYGDMLAMGILDPTKVTRSALQFASSIAGLMITTECMITELPKKDTPAMPDMGGMGGMGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RP54_ACIFI
Sequence: MKQGLELKLGQHLAMTPQLQQAIRLLQLSTVDLQQEVQGMLESNPLLDEETGDEGGGGPIPETVELPSEERQLDLAAENILPDELPVDSQWDDIFDMGTSGSGNGSDEDLPDFESRNSRTQSLQDYLRWQADMTHFTADERNMAELIIDAIDERGYLADSLEDLAATMNVQEDALLAVLLRVQDFDPPGVGARNLSECLLLQLKQMVEKDDAHVLLAQRIVKDHLQALGRHDYPRLCTVLGVDEAALRAAMALISALNPKPGEDVGTESTEYVIPDVIVRWAGSRLRTDLNPEAMPKLRINRHYADMAGGKDAAHKYIQDQLNEARWFIKSLQSRQDTILKVARAIVERQKDFFANGPESMRPMVLRHIADAVEMHESTVSRVTNQKYMITPRGLYEFKYFFSSHVGTDSGGSASATAIRALLIKMTQAEDAQHPLSDAEIARVLADQGIQIARRTVAKYREAANVPPASQRRRL
What is the function of this protein?
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.  This sigma factor is responsible for the expression of the nitrogen fixation genes.  The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein NifA for the expression of the nitrogen fixation proteins.
What are the official names of this protein?
RNA polymerase sigma-54 factor.
What is the protein family that this protein belongs to?
Belongs to the sigma-54 factor family.
Protein: ISPE_CHLL3
Sequence: MPSISVHAYAKINLGLFITGKRDDGYHNLETIFAPVSWHDTLCFSPADAISMRCTNADLPTDGSNLCIRAARSLQEYAGVGDGVSIELDKQVPFGAGLGGGSSDAATVLRVLNGFWNINATVEDLHPLAVKLGADVPYFLEMEGLAYAGGIGDELTDLHAGLPWHVVTVFPAEHISTAWAYGNFHRRFGQSRPDIRTIAADLSGIGDTGRLELFENDFQSAVFEQFPKVRRVHTDLLEAGAVFASLSGSGSAVYGLFETAMDARRAIERQRASYPTNLTPPGFSMRQ
What is the function of this protein?
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
What are the official names of this protein?
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CMK, 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. IspE subfamily.
Protein: MYADM_XENTR
Sequence: MPVQHRTIVVGNTSTLKSPVGIVRILEVIFACVTFSLVVHTGRWGGRIGDLCMFCWCFCFAVTLVILIVEFAGVQNRMPVSWKNFPITFAMYGVLMCLSATVIYPLQYLEDKAYNSEARNYQIVAIVFSCLTTLAYIIEVSLTRAKPGEVTGYMATTPGLLKVLETFIACIIFVFISDPAQYERHDAMKWCLAVYCICFILSIVVIILCVGECTGWLPCAFNKFLSGYALLAVLMYASAMIVWPIFAFDRKHGGTPSRPSYCRSGQGNLYRVCDWDKLVAVAVLTAVNLIAYIMDLVHSARLIFITV
What are the official names of this protein?
Myeloid-associated differentiation marker homolog.
What is the protein family that this protein belongs to?
Belongs to the MAL family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: IF1_FRATO
Sequence: MAKEDCIEMEGVVLEALPNTMFRVELENGRIVTAHISGKMRKNYIRILTGDKVVVEITPYDLTKGRIKFRSK
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds.  Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).  Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
What are the official names of this protein?
Translation initiation factor IF-1.
What is the protein family that this protein belongs to?
Belongs to the IF-1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MENJ_MYCTU
Sequence: MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRDKPCGDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWPGPSFPSYGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVSLTLADGTEVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSRRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGGAVSGVAGSNWMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRYGRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLVTDDDRDWVARVWRGGGQLSRLVDRRPPFS
What is the function of this protein?
Catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in M. tuberculosis, likely the beta-isoprene unit, forming the predominant form of menaquinone found in mycobacteria, MK-9(II-H2).  Is required for M. tuberculosis survival in host macrophages.
What are the official names of this protein?
Menaquinone reductase, MK reductase.
What is the protein family that this protein belongs to?
Belongs to the geranylgeranyl reductase family.
Protein: NADD_CHLTE
Sequence: MRTAVFGGSFDPPHNGHLALSLFARELAGLDRLIVSVSKNPFKAAADASDDDRSAMARLLVAEINVAGVFAEISGWELQQSGPSYTIDLLRHVEERCPGDELVLLVGEDSYLQMPQWKFASEILKHCTIAVFGRSDIDAADAPPSDPLLPAIHYDFDMPVSATKIRRLAAAGQPIGQFVPSSIAQYIAEHKLYSA
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: HP29_SARPE
Sequence: DSXVPEXFDARKXXPN
What is the function of this protein?
Involved in the dissociation of the larval fat body on metamorphosis.
What are the official names of this protein?
29 kDa hemocyte proteinase.
What is the protein family that this protein belongs to?
Belongs to the peptidase C1 family.
Protein: PNP_RALSO
Sequence: MFNKIVKEFQWGNHKVRMETGEIARQASGAVLLDMDDTVVLATVVGAKNAKPGQDFFPLTVDYIEKTYAAGKIPGGFFKREGRPSENETLTSRLIDRPLRPLFPEGFYNEVQVVIHVLSINPEVPADIPALVAASAALAVSGLPFNGPVGAARVGYKDGQYLLNPNRAQLAHSDLDLVVAGTERAVLMVESEANQLSEEVMLGAVVYGHEQMQIAINAIHDLVRDGGKPEWDWQAAPKNEALVAKVSELGLADLQAAYQLRQKSARSQKLKEVYASVAAKLAEAGVEADGVEVDNILFELESKIVRGQILNGEPRIDGRDTRTVRPIEIRSSVLPRAHGSALFTRGETQALVVATLGTKSDEQIIDALQGEYRDRFMLHYNMPPFATGETGRVGSPKRREIGHGRLAKRALIPVLPKEDEFAYTIRLVSEITESNGSSSMASVCGGCLALMDAGVPVKAHVAGVAMGLILEGNKFAVLTDILGDEDHLGDMDFKVAGTDNGITALQMDIKVQGITKEIMQVALAQAKEGRLHILGKMQAAMGHARTELSEHAPRMITVKINPEKIRDVIGKGGSTIQALTKETGCTIDIQEDGTITIASTSSEGMAEAKRRIEGITAEAEVGKIYSGTVLKLLDFGAIVNILPGKDGLLHISEIANERVNQVSDYVKEGQMVRVKLLSTDEKGRMRLSIKAAKAEEGDVPATAPQAPGAGDATSQQQ
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YJT3_YEAST
Sequence: MFQQLSASIRHNAHIIFLCISWYFISSLASQVTKQVLTVCPLPLFLGEFQFIYTAVLAWFTCYIAYSFPGFYRIFPNGTFPEYYIDDRETSRAARKESKLSSLIIPPSKPILQTVLPLGLFQFVGKYFGHTATSLVPVSTVASIKTLSPMFILLLQKILKISTLKITLTLIFSLCTLVLGVWIIVQEDNRSPASSNELREFSKYGVICAMISMFIFVLQNIYGKTVFTYRSQTDESQSNSGFSRQESPLPLYEKLDEKLVAKKKPKSYDKLTLMIYISLVGFCLSFGWFITLEFPVLFRYFFQINSSSTVIKAFPVSLFLLNGTFHFIQAMITFHLLGEVSTLTYSIANLMKRFAIIAVSWVFIGRRITWLQVFGLVLNTLGLFLYERCTSQSKIKAKIRPE
What are the official names of this protein?
Uncharacterized transporter YJL193W.
What is the protein family that this protein belongs to?
Belongs to the TPT transporter family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: DNCH_NOSS1
Sequence: MPFTYHRTINFQDTDAAGVVYFANILSICHEGYEASLRTSGISLKEFFTNPSMAFPIVHASVDFLRPLFCGAQVIISLVPQKIGAEKFEINYEIYLADVLVAKAVTRHVCIDANTRSKQELSMEIIQWLDGYRKDTEEVERRKAREVV
What is the function of this protein?
Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
What are the official names of this protein?
1,4-dihydroxy-2-naphthoyl-CoA hydrolase, DHNA-CoA hydrolase, DHNA-CoA thioesterase.
What is the protein family that this protein belongs to?
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.
Protein: KHSE_STAA1
Sequence: MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPILCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGFYNDVSKETSVAHIDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDEVKTIASQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ
What is the function of this protein?
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
What are the official names of this protein?
Homoserine kinase, HK, HSK.
What is the protein family that this protein belongs to?
Belongs to the GHMP kinase family. Homoserine kinase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_ASPNC
Sequence: MGVTIVLGSQWGDEGKGKITDMLAQQATLCCRAAGGHNAGHTIVHGDKTYDFHILPSGLVSPSCVNLIGAGTVVHVPSFFKELASLEDKGLEGAGKRIFISDRAHVCFDLHSVVDGLEEAKLGGRKVGTTGKGIGPCYSDKAARRGVRVGEILDEALFERKLRSLDAGYRARFGELEYNVEEELARFKEYRKRLGPYIVDQLAFLQKYKDAPNTLVEGANALMLDLDHGTYPFVTSSSTGLGGAVQALSLNPTSISSIIGVVKAYTTRVGSGPFPSEQLNDAGDKLQGVGKEFGVTTGRRRRCGWFDMVLCRYSQAINHYTALNLTKLDVLDDFDEIKVGVAYILPDGTRTENTMPADPEVLEKVQVEYVTLPGWKSNTMGVKKYEDLPANARAYIEYIERGLGGVPVKWIGTGPARDHMICRE
What is the function of this protein?
Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSF3_NEUCR
Sequence: MSYYDIDAILTDAEKIPCTFQIDVPDLGYLDNQPGHTLKSGSRVALPIWLAEMLAIANTGAVDMDDPSQSSKSFITFDLPPALGNDVVQALKADPRSVPLRDQSAHFYALATHMMELSEEPELSAVLRKTFVSRAAEIALHARKVGGGGSSYHGRDGGGAGGKGKGKATKDDNASNLGVGGAGEDFLRGLDEWERKLFRSAHDGTKASKEWMENVKKR
What is the function of this protein?
The GINS complex plays an essential role in the initiation of DNA replication.
What are the official names of this protein?
DNA replication complex GINS protein psf3, DNA replication complex protein 3.
What is the protein family that this protein belongs to?
Belongs to the GINS3/PSF3 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PA24C_MOUSE
Sequence: MELSSGVCPATRLQEAEKAAVHKRSPKVLEALRKLNIQADQAPVIAVLGSGGGLRAHIACLGVLSELKELGLLDAVTYLAGVSGSTWALSSLYTKNGNMEGIEEELKHRYEKNEWDFHESLEKAIQASKRENYSLTDFWAYLIVSRQIRELQDSNLSSLKKQVEEGVLPYPIFAAIDEDLLADWRERKTQNSWFEFTPHHAGYPALGAYVPITEFGSRFENGKLVKSEPERDLTFLRGLWGSAFADIKEIKNYILNYFRNPFGKLKFIEGPVTYSEAPRMNVDAMLLDLVMAYFTDMNDPSIKDKLCALQQALGTETDEFGIEMAEIIQNWNETSAEKKEQFLDHLLDRFKKTQEDTTTYSLMNWNTGLVWDRCVFVNETRKCVSKWQWGTVYNFLYKHGKIADETMCSRELLHLVDAGFAINTPYPLVLPPVRETHLILSFDFSAGDPLETIRATADYCQRHEIPFPEVSEDQLKEWAKAPASCYVLRGETGPVVMHFTLFNKDNCGDDIETWRKKYGTVKLSDSYTPDLVRDLLRVSKENVKKNKINILSEMRKVAGNPGNIPRVNKEACLGDRVKDPQGSQTVEFKKSHNISKD
What is the function of this protein?
Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling.  Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles.  Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids.  Cleaves ester bonds but not alkyl or alkenyl ether bonds at the sn-1 position of lysophospholipids.  Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency.
What are the official names of this protein?
Cytosolic phospholipase A2 gamma, cPLA2-gamma, Cytosolic lysophospholipase, Cytosolic lysophospholipid O-acyltransferase, Phospholipase A2 group IVC.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm. Nucleus envelope. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, spindle. Note=In germinal vesicle stage oocytes and early embryos, shows mainly uniform nuclear and cortical expression. During germinal vesicle breakdown, found in intensely stained foci which accumulate near the dissolving nuclear envelope. Also localizes to spindle poles at metaphase II.