PharMolix/UniProtQA huggingface dataset:
Protein: CYOA_BUCAP
Sequence: MISINFNNFFKTLLLILIAFTLHGCDSILFNPHGIIAIQECSILLISFLIMLFVIIPVIFMTIYFSVKYRASNINAKYKPDWCDSKKIEIIVWTIPISIILFLAFVTWNYSHILDPKKSIISKYKPIKIDVVSLDWRWLFIYPEYHIATINEIMFPINRSIIFHITSNSVMNSFFIPSLGSQIYAMPGMMTTLNLMSNSPGKYKGISSNYSGKGFSNMKFTAISVLNIKDFENWIKKAQQSPKKLNKMSIFNIISLPNENHFIEYFSDVKKNLFYEIINQTYSKNKVFKH
What is the function of this protein?
Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E. coli that predominates when cells are grown at high aeration.  Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity).
What are the official names of this protein?
Cytochrome bo(3) ubiquinol oxidase subunit 2, Cytochrome o ubiquinol oxidase subunit 2, Cytochrome o subunit 2, Oxidase bo(3) subunit 2, Ubiquinol oxidase polypeptide II, Ubiquinol oxidase subunit 2.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: TM39A_MOUSE
Sequence: MPSRRRGPSRQQLSRSALPSIQTLVGGGCGNGTGLRNRNGNAIGLPVPPTTALITPGPVRHCQIPDLPVDGSLFFEFLFFIYLLIVLFIQYINIYKTVWWYPYNHPASCTSLNFHLIDYYLAAFITVMLARRLVWALISEATKAGAASTVHYTALILARLVLLTLCGWVLCWTLVNLFRSHSVLNLLFLGYPFGVYVPLYCFHQDSRAHLLLTDYVVQHQAVEEAASNVGSLARSKDFLSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVECLKADFNHRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCEHLIMVWINAFVMLTTQLLPSKYCDLLHKSAAHLGKWQKLEHGFYSNAPQHIWSENTIWPQGVLVRHSRCLYRAMGPYNVAVPSDVSHARFYFLFHRPLRVLNLLILIEGSVVFYQLYSLLRSEKWNHTLSMALILFCNYYVLFKLLRDRIVLGRAYSYPLNSYELKAN
What is the function of this protein?
Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools (By similarity).  Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L (By similarity).
What are the official names of this protein?
Transmembrane protein 39A.
What is the protein family that this protein belongs to?
Belongs to the TMEM39 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: ISPF_CLOK5
Sequence: MRVGLGYDVHKLGYNTPLILGGVNIPFNKGLIGHSDADVLVHAIMDALLGALSLGDIGKHFPPSDMKYKNISSLKLLNYVSNLIKSKGYSIGNIDSTIIAEEPKLFPYIPDMRLNIAKILKVNTSIISVKATTEEGLGFTGKKEGIAAQSICLLYNNLKHSIDL
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: CLPX_ANAPZ
Sequence: MSETKKGAYSCSFCGKLHSEVKKLIAGPEAYICNECVELCGGILQEENLPAKQGRFDLKPREIKEVLDEYVIGQEHSKKVLSVAVYNHYKRLRNSGVISEVEISKSNVLLIGPTGSGKTLLARTLARVLQVPFAMADATTLTEAGYVGEDVENILLKLLQAANFNVEAAQRGIIYIDEVDKISRKSENASITRDVSGEGVQQALLKVIEGTVSSVPPQGGRKHPHQEFIQISTDNILFIFGGAFDGLEKIIEARNRGSSMGFEANVQSMVSPTKDVLSYAEPEDLVKFGLIPEFIGRIPVITSLGKLDENTLFRVLVEPKNSLVKQYAKLFEMDNLELKFDDDALMAIARKAVDRNTGARGLRAIMESLLLDFMFDPQGCAHEGKVSISKEMVENLVLGKNCFEDARKGNLYGRG
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: HMUV_GLOVI
Sequence: MLKAAGIGVRLAGRWLLEQVNLEALPGEVLAVVGPNGAGKSTLLKTLAGEIRPTRGSVSMAGKALADWPARERACVRAVLPQNSTLAFAFRVFEVVLMGRTPHSRGLEGERDRQIAREAMAAAGVAHLAERLYPTLSGGEKQRVQLARVLAQIWEAPPDSPRYLLLDEPTASLDLTHQHSTLAVARNFAHRGAAVVTVLHDLNLAAQYADRLALLKDGKLLVVGVPDIVLTPEWIETGFGLQTLVMRHPRLGCPLVIPLGSASVLQPGEQLAHGK
What is the function of this protein?
Part of the ABC transporter complex HmuTUV involved in hemin import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Hemin import ATP-binding protein HmuV.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RUVC_PROM2
Sequence: MRIIGIDPGLARVGYGIIEIENEKKILLDCGVIETGKDKKEEDRLYEIFKDLNELINHWNPTSAAVEKFFFYRSSTTISVVQARGVIMMVLASKKIQVSEYSPAQIKLTIAGSGKASKKEVLDAVMFSLELKKPPKPDDSADALAIALTKLNEDGIN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair.  Endonuclease that resolves HJ intermediates.  Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction.  The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'.  Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange.  HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Crossover junction endodeoxyribonuclease RuvC, Holliday junction nuclease RuvC, Holliday junction resolvase RuvC.
What is the protein family that this protein belongs to?
Belongs to the RuvC family.
Protein: RL25_BRUMB
Sequence: MSETYVLKADLRTRVGKGSSRELRRNGQIPAVIYGDKQEPLAIAVSYKEIFYKIHGGGFKTTVATIEVDGKKIQVLPKDYQLDPVRDFPQHVDFLRVSAKSVVHVNVPVHFKNEEAAPGIKRGGVLNVVRHDVELIVPANAIPEALEIDLSGLEIGDSVHISAVKLPKGATPAIQDRDFTIATIAAPAGLKSEENAEGAAEEAKDGE
What is the function of this protein?
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L25, General stress protein CTC.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
Protein: P5CR1_DICDI
Sequence: MKLYDNGVAVLGCGNLGNAIAKGLVASKQFKSNQIVLTKRNLSTIEPLKREGYHVTTSNHDAVSRCKIVIVCVVPAQLDDLLDSIKQSVTENHIIISVVSGASIEDIRSHLEKDVPIVRAMPNTAIQHCQSMTCLAIRSSHQKSTNSPSDKAKDNALEVAKKIFNCLGMSIVLSEEQIVPATALCACGIAFFCRAIRAAAQGGCEIGFHAEDAIRIAAQTAKGAATLLLENNFHPEYEIDKVTTPQGCTIAGLNQMEHAGFSSAMIKGIVTSSDKAASLYTQKQQNKKQQQLKQQQHQQHQHQQHQQHQQQVQQQEPHQYQQQQQQSHQQSQYNQGHNYGHQNQHHHNHDDQHQNYYNQDQKRRNNRKHRSNENYDNHHHHNQQYQQHQQPTQQESQEQTQQPEQTQSTNQSNQRRNSESRNGKSPQKQPQKQSQVQQPSSTTENTDQQQQQQPPQEQQQQQEQPQQPQEQQQQPNVVDEAERPKEQQQQPQQQQQTIDKKGYNNNRRGGRHYSYNNNYNSHHHRHNGINKNSSSMYHDEKRHEVKTEQIN
What are the official names of this protein?
Pyrroline-5-carboxylate reductase 1, P5C reductase 1, P5CR 1.
What is the protein family that this protein belongs to?
Belongs to the pyrroline-5-carboxylate reductase family.
Protein: CYB2_TALSN
Sequence: MARVLDAAEVAKHNTPESCWVILYGKVYDVTEFISSHPGGVKVILRLAGTDATEEYDPIHPPGTLEENLKPEALLGTVDPETLPKPDKQQSSPEEEEQGPPPMETLFNLDEIEQVATKQVSRKAWGYYYSAADDLISKNFNREIYRSILLRPRVFIDVGKCDLSTTILGHRVGLPIYISPAAMARLAHPAGEAGIAAACRGFGAMQMISNNASMSPEQIVENAAPDQVFGWQLYVQMERKKSEAMLARVEKLKAIKCVILTLDAPVPGKREDDMRTDNIGKKLPVSSAKVAEKEVETLPDGTPVPTDGGGGVGKQLFAGTAYDLTWKETLTWLTKVTKLPIILKGLQTHEDAYIASLYAPQVKGIILSNHGGRALDTAPPAVHTLLEIRKYCPEVFDKIEVLVDGGIRRGTDVVKALCLGARAVGIGRPALWGLGAGGIAGVERTLEILADETKTCMQLLGVEKISDLGPEYINSRIVEQQIYDGPSGLEKARAKL
What is the function of this protein?
Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate with subsequent transfer of electrons to cytochrome c.  Also displays oxidase activity in vitro, catalyzing the oxidation of a broad range of 2-hydroxyacids, such as glycolate, (S)-lactate, 2-hydroxyoctanoate, (S)-2-hydroxyglutarate and to a lesser extent mandelate, to the corresponding 2-oxoacids, with a reduction of O2 to H2O2 (PubMed:34555022).  However, the physiological activity of this enzyme is most likely to function as an L-lactate dehydrogenase.  May be involved in the utilization of (S)-lactate as a sole source of carbon for growth (Probable).
What are the official names of this protein?
L-lactate dehydrogenase (cytochrome).
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion intermembrane space.
Protein: FLGI_RHOP2
Sequence: MPSVSAVILKLAAAALSALLLSGVAANATSRIKDLANIEGVRQNQLIGYGLVVGLNGTGDTLNNIPFTKQSLQAMLERMGVNIRGATIRTGNVAAVMVTGNLPAFATQGTRMDVTVSALGDAKNLQGGTLLVTPLLGADGNVYAVAQGSLAIGGFQAEGEAAKITRGVPTVGRIANGAIIEREIEFALNRLPMVRLALRNADFTTAKRIAAAVNDFLGTKSAEPIDPSTVQLTIPAEFKGNAVAFVTEIEQLQVEPDQAAKIIIDERSGIIVMGRDVRVATVAVAQGNLTVSISESPQVSQPNPLANGRTVVTPNSRIGVTEDGKKLALVKDGVSLQQLVDGLNGLGIGPRDLIGILQAIKAAGAIEADIEVM
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: ATPD_ERWT9
Sequence: MSEFTTVARPYAKAAFDFAVEHQSVDRWQQMLAFAASVASNEQMTDLLSGALAPEALSETFIAICGDQLDEAGQNLIKVMAENGRLPTLTAVLEQFIQLRAAHDATAEVEVISSTTLSDEQLTKISAAMEKRLSRKVKLNCKIDKSVMAGVIIRAGDMVIDGSVRGRLERLADVLQS
What is the function of this protein?
This protein is part of the stalk that links CF(0) to CF(1).  It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
What are the official names of this protein?
ATP synthase subunit delta, ATP synthase F(1) sector subunit delta, F-type ATPase subunit delta, F-ATPase subunit delta.
What is the protein family that this protein belongs to?
Belongs to the ATPase delta chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: RS24_SULIY
Sequence: MESQAKVKISDKAEGIIERDVQNAVIGRREISLKVYHMGSGTPSRKDIIKAIIQAFASQENLVVVRKISTSYGAGISNIKLHIYKSREILEKIEPKYLLDRDAGTKQKKGGSKGGQGAKG
What are the official names of this protein?
30S ribosomal protein S24e.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS24 family.
Protein: RNFC_PECCP
Sequence: MLKLFSAFKKDRIWDFDGGIHPPEMKTQSSRTPLRQIPLPEQFIIPLKQHLGPEGEICVSVGDKVLRGQPLTRGRGRTLPVHAPTSGTVNAIRQHTTAHPSGLSELSIIIVPDGEDRWSDRQTLADYQTQSTDTLLAHLHQAGIAGLGGAGFPTAAKLQGGMRGIETLIINGAECEPYITADDRLMQECADEIIQGVEILSFLLQPKRILIGIEDNKPEAISALRLALGKRSDMQLRVIPTKYPSGGAKQLTKILTGKEVPFGKHSAAIGVLMQNVGTAFAIKRAVIDGEPLTERVVTLTGEALRQPGNVWARLGTPVRHLLKQGGFHVNKQPMVVMGGPLMGFTLPSLDVPIVKISNCLLAPSHTEMEPVAEEQSCIRCSQCADACPAGLLPQQLYWFSRGQEHEKARNHHLFDCIECGACAYVCPSNIPLVQYYRQEKAEIRAIDEDAQRAAQAKVRFDAKQARLEREKAARELRHKQAATGVSTSDKDAVQAALERVRRKQSTTTEIGAPIAVMPDAQPDNSAAIAARAARKALVREERARENQTQQETPTVDVPSTELDDPRKAAVAAALARVKARKAAQQTATNAEAPVSSVTSDVVAEPVAVVETQEPDDPRKAAVAAAIARVKARKAAQQTATNAEAPVSSVTSDVVAEPVAVVETQEPDDPRKAAVAAAIARVKARKAAQQTATNAEAPVSSVASDIVAEPVAVVETQEPEDPRKAAVAAAIARVKARKAAQASSHQEE
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit C, Rnf electron transport complex subunit C.
What is the protein family that this protein belongs to?
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: DAPA_THEPX
Sequence: MPVFKGSGVAIVTPFNEEGVNFEKLGELIEWHIKEGTDAIIICGTTGEASTMTQEEQQQAIKFTVEKVAGRIPVIAGTGSNNTAHAVEMSEYAQSAGADALLVITPYYNKTTQKGLVAHFTEIARHVDIPIIIYNVPSRTSLNMLPETYLELSKHVDNVVGVKEASGDIVQVAEIARIMGKSFEIYSGNDDQVIPIMSLGGLGVISVTANIIPAKIHEMTTAYLNGDIEKARDMQLELNPLNKALFIETNPIPVKTAMNLMGFNVGPLRLPLVEMSDKNLEYLKSVLSKYGLLKEAN
What is the function of this protein?
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
What are the official names of this protein?
4-hydroxy-tetrahydrodipicolinate synthase, HTPA synthase.
What is the protein family that this protein belongs to?
Belongs to the DapA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CCNC_CAEEL
Sequence: MALNFWKSSHCQQWIFDKTEIWKQRAEDMKIYNEEEYNRLNIFWANFITAVATEGAHSQANVGCKLRQQVIATAIIYFKRFYLRQSFRDMCPFLVASTALFLACKVEEHTTLSVSSFLKNTAIVLPKRWGVTFETTSTKNGVVYDSEFILVEILDCCLVVHHASRPMFELLEDLKQFTQQSTIANQPIKDLEAIEAQCQKVANDSLRCDVSLIFPPHVIGLSSIMVAMELMGRGEELEAWLVEVDTDFEKVTDCVEQIYKMYTLWKSFDEKEEVKKLMAKLPKPNQQPPPQQQHQHQQGYHL
What is the function of this protein?
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes.  Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.  Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.  Binds to and activates cyclin-dependent kinase cdk-8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
What are the official names of this protein?
Cyclin-C.
What is the protein family that this protein belongs to?
Belongs to the cyclin family. Cyclin C subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: NCASE_ORYSJ
Sequence: MEASSWLCYQARGFGSSRVWLWLLLALVLLNCSLVLSASPYLVGMGSFDITGPAADVNMMGYANTEQIASGIHFRLKSRAFIVAEPNGKRVVFVNIDACMASQIVTIKVLERLKARYGDLYNENNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQSFDVIVDGIEQSIVEAHNNLRPGKIFVNKGDLLDAGVNRSPSAYLNNPAEERSKYEYNVDKEMTLIKFVDDELGPVGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWAEQMGLPKQSAHANSDDLRSLHKTSVLPRRVSTIIPEPNEITDDLIQLASSYEASGGRRLAGSSITRRIRSTQQNKPKFVSAFCQSNCGDVSPNVLGTFCIDTNLPCDFNHSTCNGKNELCYGRGPGYPDEFESTRVIGNRQFLKARDLFDSASEEIQGKIDYRHTYLDFSKLEVKVSTSAGGQQTVKTCPAAMGFAFAAGTTDGPGAFDFRQGDVKGNPFWKLVRNLLKTPGKDQVECHSPKPILLDTGEMKEPYDWAPAILPVQMIRIGQLVILCVPGEFTTMAGRRLRDAVKTVLTSGNSEFDKNIHVVLAGLTNSYSQYITTFEEYQIQRYEGASTLYGPHTLSAYIQEFQKLAMAMIANKEVPTNFQPPDMLDKQIGLLPGVVFDSTPLGVKFGDVNSDVPGNSTFNKGSTVNATFYSACPRNDLLTDGTFALVEKLDGNNNWVPVYDDDDWSLRFKWSRPARLSSRSFATLEWTVPEDAAAGVYRLRHFGASKPMFGSVRHFTGTSRAFAVR
What is the function of this protein?
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.  Uses ceramide instead of phytoceramide as substrate.
What are the official names of this protein?
Neutral ceramidase, N-CDase, NCDase, OsCDase, Acylsphingosine deacylase, N-acylsphingosine amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the neutral ceramidase family.
What are the subcellular locations of this protein?
Secreted. Endoplasmic reticulum. Golgi apparatus.
Protein: CH10_ESCF3
Sequence: MNIRPLHDRVIVKRKEVETKSAGGIVLTGSAAAKSTRGEVLAVGNGRILENGEVKPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIVEA
What is the function of this protein?
Together with the chaperonin GroEL, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.  GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
What are the official names of this protein?
Co-chaperonin GroES, 10 kDa chaperonin, Chaperonin-10, Cpn10.
What is the protein family that this protein belongs to?
Belongs to the GroES chaperonin family.
Protein: NUSB_CHLL2
Sequence: MKTYRRQIREKILQALYTIELRDTDIDSAAGWLLTQEILDDPNAMKFFNMLIGSIKAHMSEIDCYIERHTFNWDMSRIAIIDKNILRMALAEILYCEDIPPKVSINEAIEIAKKFSSTEKSSKFVNGILDAIFNELKTDGKIHKNGRGLIDHSTAKLHKNETSK
What is the function of this protein?
Involved in transcription antitermination.  Required for transcription of ribosomal RNA (rRNA) genes.  Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
What are the official names of this protein?
Transcription antitermination protein NusB, Antitermination factor NusB.
What is the protein family that this protein belongs to?
Belongs to the NusB family.
Protein: RL22_GEOSL
Sequence: MEASAKLTFARLSPRKTRLVVDMVRGKGIQDALTILRFSPQASAKLVSKLLRSAVANAEQKGASDVDRLYVKSISVDGGPVLKRFVPRAMGRASKIRKPTSHITVVLADKQ
What is the function of this protein?
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L22.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL22 family.
Protein: HAS1_USTMA
Sequence: MAPHKSDDVDAEAELASQLAADVAAAESSAATKAKASSASSSSTPAAERQPFSILDLSEPTRKAIDAMGFKTMTEVQARCIPPLMAGKDVLGAAQTGSGKTLSFLIPAIEMLHRLKFKPRNGTGAIIISPTRELALQIFGVAKELMAHHHQTFGIIMGGANRRAEADKLQKGVNLIVATPGRLLDHLQNTKGFVFSNLKALCIDEADRILEIGFEDEMRQIVKILPNDNRQSMLFSATQTTKVQDLARISLRPGPLYINVHADLAASTVSRLEQGYVVCESDRRFLLLFTFLKKNAGKKIIVFMSSCNSVKYHSDLLNFIDVPVLDLHGKQKQQKRTNTFFEYCNAPCGTLLCTDVAARGLDIPSVDWIIQFDPPDDPRDYIHRVGRTARAGNSGKSLLFLLPTELGFLRFLKVAKVPLNEYTFPSDKVANVQGQLEKLISKNYYLHQSARDGYRSYLQAYGSYSLKRIFDIHKLDLAKVAKAYGFSVPPKVNITIGTGLKTSASSSSGSGGKRKEVDVDGEGEDADGEINPKRQQSDRRAYYRKNHQNGGSKDHFRKSGANATGNKGGKQWSR
What is the function of this protein?
ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis.  Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
What are the official names of this protein?
ATP-dependent RNA helicase HAS1.
What is the protein family that this protein belongs to?
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: PNOC_BOVIN
Sequence: MKILFCDLLLLSLFSSVSSSCQKDCLVCREKLRPTLDSFSLEMCILECEEKAFTSPLWTPCTKVMARGSWQLSPADPDHVAAALDQPRASEMQHLKRMPRVRSLFQRQKRTEPGLEEVGEIEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGNA
What is the function of this protein?
Has potent analgesic activity.
What are the official names of this protein?
Prepronociceptin.
What is the protein family that this protein belongs to?
Belongs to the opioid neuropeptide precursor family.
What are the subcellular locations of this protein?
Secreted.
Protein: MNMG_CHLPN
Sequence: MWTHPIAYDVIVVGAGHAGCEAAYCSAKMGVSVLMLTSNLDTIAKLSCNPAVGGIGKGHIVREIDALGGIMAEVTDQSGIQFRILNQTKGPAVRAPRAQVDKQLYHIHMKRLLENTPGLHIMQATVESLLDKEGVISGVTTKEGWMFSGKTVVLSSGTFMRGLIHIGDRNFSGGRLGDPSSQGLSEDLKKRGFPISRLKTGTPPRLLASSINFSCMEEQPGDLGVGFVHRTEPFQPPLPQLSCFITHTMEKTKAIISANLHRSALYGGCIEGVGPRYCPSIEDKIVKFSDKERHHVFLEPEGLHTQEIYANGLSTSMPFDVQYDMIRSVLGLENAIITRPAYAIEYDYIHGNVIHPTLESKLIEGLFLCGQINGTTGYEEAAAQGLIAGINAVNKVFNRPPFIPSRQESYIGVMLDDLTTQILDEPYRMFTGRAEHRLLLRQDNACARLSHYGYELGLLSEERYELVKKQNQLLEEEKVRLQKTFRQYGQSVVSLAKALSRPEVSYDMLREAFPNDIRDLGAVLNASLEMEIKYSGYIDRQKILIQSLEKAESLLIPEDLDYKQITALSLEAQEKLAKFTPRTLGSASRISGIASADIQVLMIALKKHAHH
What is the function of this protein?
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
What are the official names of this protein?
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG, Glucose-inhibited division protein A.
What is the protein family that this protein belongs to?
Belongs to the MnmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPP1_RHOJR
Sequence: MTNLFDPRSLGGQAPAGPQSRYILPSFIEHSSYGVKESNPYNKLFEERIIFLGVQVDDASANDVMAQLLVLESLDPDRDITMYINSPGGSFTSLMAIYDTMQYVRADITTVCLGQAASAAAVLLAAGSPGKRLALPNARVLIHQPATGGIQGQVSDLEIQAAEIERMRRLMETTLAKHTGKDAAVIRKDTDRDKILTAAEAKEYGIIDDVLEYRKLSAQK
What is the function of this protein?
Cleaves peptides in various proteins in a process that requires ATP hydrolysis.  Has a chymotrypsin-like activity.  Plays a major role in the degradation of misfolded proteins.
What are the official names of this protein?
ATP-dependent Clp protease proteolytic subunit 1, Endopeptidase Clp 1.
What is the protein family that this protein belongs to?
Belongs to the peptidase S14 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MIAB_NATTJ
Sequence: MTLYQLGNGKKFYTLTFGCQMNEHDSEVLAGMLDQMGFEKAASEEEADLLIINTCAVREKAEQKVLGKIGTLRYLKENKPDMKIAIGGCMVQQEHVANKIYRDFTHVDIIFGTHNINRFPQLLEHVMQKGKRVKEISQDDSQVFENLPHKREDSIKAWVVISYGCDNYCKYCIVPYVRGQQRSRDPEHIKYEVEKLAKEGLKEITLLGQNVNSYGKDLDQNISFTNLLEELSKIEGIERIRFMTSHPKDFDKELITTLKESNKICEHFHLPVQAGSNKILKKMGRGYTREHYVDIVNDIRAELPNASITTDIIVGYPGEEEEDFQETLDLVQNVKFDSAFTFVYSKRSGTPAAEMAEQVDEQTKKGRIQKLISVQQEISEQRNKDLENTVQRILVEGVSKNNEDMLSGRTRTDKLVHFPGDKELIGELVDVKITRGHSWNLYGEIFEDSLT
What is the function of this protein?
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
What are the official names of this protein?
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase, (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB, tRNA-i(6)A37 methylthiotransferase.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RRP42_SCHPO
Sequence: MQLSLPELSYTHKSITEFEPAIRNDGRSIDQLRPLSGQVDVLPGTNGSARVKWASSVEIVIGVKAEVGDATPEGGKYVASVEISPSVSIQNRETDEIPSFLTSALQDLLNALAVDYLKFTPSKAWIIHVDAVVILSSSPYENILSALSLAAYLALQTTRLPKISTPNVTDITIGSTKYEPSEEYDVDSEWENALPLQGLELMSVIILVSSIDQVIIVDPTIEESSVAQVTYAIGVQASGAISYTRVVGTGGGYASTGRAITVERYIELLETASTVGTKLLNASSDILSFKGLGFFDILP
What is the function of this protein?
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.  In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs.  The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.  ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation (By similarity).
What are the official names of this protein?
Exosome complex component rrp42, Ribosomal RNA-processing protein 42.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus, nucleolus.