Protein: SDGA_EMENI
Sequence: MAYDNTVVEPIAIIGTGCRLPGGSSSPSRLWTLLKNPRVVASETPGDRFDINAFYHEDPGYPGTTNSKEAYYISDDPRPFDAPFFNISATEAESIDPQQRQLLETVYESLESAGLRLDALQGSSTGIFCGVMNNDWGELQSADYKSLPQYLATGAARSIIANRISYFFDWHGPSVVVDTACSSSMVALHHAVTALQQNECTLALATGTNLIQAPNIFISTTKIQMLSPTGRSRMWDANADGYARGEGVISIVLKRLSDAIRDGDDIECVIRATGTNQDGRTMGLTMPSSVSQLQLIQSTYARAGLDPRRVQDRCQYFEAHGTGTLAGDPQEAAAIHHAFFGPPASPEKNGVYNGCDVSVNGAANGAFADDNDILLVGSVKTVVGHTEGTAGLAGIIKASLNLQHGLISPNLLFETLNPALEPFASHLKVVTELTPWPSLPTGAPRRVSVNSFGFGGTNAHAILESYDANVKESGSTVAAGQSLTAALLPFVFSAASEGSLAAVLNSYAGYLKGKPALNLVDFAVTLLRRRSALKFRVSLWASSTEELIGKMEEEAEAIGKRTKTTNSRRCSDTPRILGVFTGQGAQWTQMGWELVGASPVARAWLEEMQNSLNDLPTKYRPSFSLTGELSNSVSKMKSATLSQPLCTALQIIIVNFLRAIGVSFTSVIGHSSGEIAAAYAAGYLTATDAIRIAYLRGFMASRAGGRNSQPGAMLAAGVSAQEAADICAKSKGTITVAAENAPFSVTFSGDANAIQSLEKKLKDENKFCRILQVDTAYHSHHMEPCCRPYLDALEECNISVKDAISGITWYSSVHPGDYIDSASLRGAYWIENMAMPVLFSQAVAHALDEGDSPPDFVIEVGPHPALKGPVQQNIAEFFPAASNVTYLAPCIRGSSSIASLSNVIGSLWETIGAGAIDTTRYLRLFGLGQAKFIKDFPTYPFDHSRSYLAQSRMIKNHLHKRSVPHPLLGSLEPESADGEWRWRHYIRQKDLDWLNGHCIQAQPVFPATGYIVMALEAASSLSSRSIQSIQLGDVAIHQAITLPENEAEGVETLFRFNRMETTDEMTSGTFHIHASTGDAFQLRASGQMIISWGAPNPDLLAQSSGSGSAGMSAVDVDELYAFLAKVGYGYSGVFRGIRSLYRQKDASHGEIQDVLPDGKPCRFLLHPALLDCTLQTMLGAIGAPDDGELYTLLVPTRIKSVIVNSALCRNPTGETFLSNANVTQIDADGISGDVSLFTHNNEGIVQMEGVEIAPLVQPPTERVVFSKLAWGPLNPGHGSFADPVDFSTHALTMEHVALLYIKLVNSQLTDDERRNLAQDHHRSRLAAWIDRTLTKTSAGEHPILHKDWMNGTQADLDTLLAEASGSVMAEIANVVGTTLRRFFRGEASILEEVRKNDVLTRFYRHDVETEMMNERLGRIVGQLAFRYPRMKILEIGAGTGSATHSILENIGRSYHSYTFTDISVGFFEEARSAFAAHEDRFLFAPLNVEIDPAHQNFEAHSYDLIVAANCLHATRSMVETMAHVRSLLKPGGYLVMLEITNLDAIRATFLMGGFEGWWAGEKDGRIWGPMLDVLTWEQLLRDSGFGGIDLRVGLGDPKLCLYEVLVAQAVNDQVNLLREPLSAQAETHTQQQWGDLLILGGSTAKTSALVKELGQMLKARFHLVLVAPTLESLSLTGCSQLSVLCLTDMDSPCFRGLTEQRLQALQMLISVTHKLLWVTAGPESDCLDLGLTKGWLRSLAYERRESLHQYLNVENADAVTAELLATTLMRLVYTESGNDYMLSRLVHATEHEMYFRNGRMDICRLQYENDMNQRYLSARQWLSKQVRATDEISVVPVGKNRYKLRVGTGERQLLRCQSVDGVRIHVQYSTVSAVPVGDGFLHLVLGEDKSTGARLIALTERYENTIECPESWTFKVRHEILAGKEALFLGILAGVLLAAYLVDKTPPHSTLFVHKAGPALCNAIWTRALGKNVNPFFTTDTPTSKTQNTTFVHPRVSTRRLKELLPRNIAVAAALDGNTTDGVSSRVKGLLSLPVRVETLETLYRSSPLRPVCGDTEIHDLLQSSCLLATRLSDMDQQVTVVGIDTVANQDVQPDHILNWNPSSPFEAQVKPVTSLVTLSASKTYILAGMTGDLGQSICEWMVSKGARHVVLASRTPKVAPDWIRTMARKSARVLSLPMQVLRIVSSMRTVLIVYRTIQQQQFPAVGGVVNGALVLEDRLFEQMTLDVMQSTFAAKVQGSMLLDELSGPDVDLDFFILFGSITGVVGNFKQTAYSAATGFQSSLIHARRARGLVGSIIHPGLISGVGYITRKGSRWVQHVRKTTGSLLLSERDIDKLFAEAILAGRPECDSDPEIVIGLPLIDLEQHPDIFWSSNPLTWDFIDYSIKSTSQLGGTLHSRGSLKAVLQSDSISSIEDITPIVSEALIAKVRSKFSVSANTIVSPSTQLTDLGVDSLVAVDIRTWFATELAVDIPLLQILGGASIEELTATAVAKLPAGVDLIDDDSVLGTV
What is the function of this protein?
Highly reducing polyketide synthase (HR-PKS); part of the gene cluster that mediates the biosynthesis of the polyenes aspernidgulenes (PubMed:30302871).  The carbon backbone of aspernidgulenes is synthesized by the HR-PKS sdgA, which accepts acetyl-CoA as the starter unit and performs malonyl-CoA extensions as well as regioselective methylation and reduction (PubMed:30302871).  The resulting nonaketide offloads the HR-PKS by intramolecular lactonization to yield the 5,6-dihydro-alpha-pyrone-containing hexaenoic acids preaspernidgulene A1 and A2 (PubMed:30302871).  The FAD-dependent monooxygenase sdgC then installs the first epoxide on the penultimate double bond (PubMed:30302871).  Subsequently, the FAD-dependent monooxygenase sdgF presumably generates a ketone intermediate through Meinwald rearrangement involving a hydride shift (PubMed:30302871).  Next, sdgC introduces another epoxide on the last olefin of the ketone intermediate after E/Z isomerization (PubMed:30302871).  The epoxide hydrolase sdgD then catalyzes stereospecific cyclization of the 5,6-dihydro-alpha-pyrone and opening of the epoxide ring to form an oxygenated trimethylcyclopentanone and an oxabicyclo[2. 2. 1]heptane unit (PubMed:30302871).  Finally, the bicyclic unit undergoes hydrolytic cleavage, either spontaneously or catalyzed by sdgD, to assemble the dimethyl-gamma-lactone moiety in aspernidgulene A1 (PubMed:30302871).
What are the official names of this protein?
Highly reducing polyketide synthase sdgA, HR-PKS aurvA, Aspernidgulenes biosynthesis cluster protein A.