PharMolix/UniProtQA huggingface dataset:
Protein: NDUS4_RAT
Sequence: MAAVSMSVSLRQALLRQRAVATAAVSVCRVPSRLLNTSTWKLADGQTRDTQLITVDEKLDVTPLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSAKEDAVAFAEKHGWSYDVEGRKVPKPKSKSYGANFSWNKRTRVSTK
What is the function of this protein?
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.  Complex I functions in the transfer of electrons from NADH to the respiratory chain.  The immediate electron acceptor for the enzyme is believed to be ubiquinone.
What are the official names of this protein?
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial, Complex I-18 kDa, CI-18 kDa, NADH-ubiquinone oxidoreductase 18 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the complex I NDUFS4 subunit family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=The interaction with BCAP31 mediates mitochondria localization.
Protein: METAA_RHILW
Sequence: MPIKIPDTLPAFETLVQEGVRVMTETLAIRQDIRPLQIGLLNLMPNKIKTELQMARLVGASPLQVELSLIRIGGHKAKNTSEDHLLAFYQTWEEVKHRKFDGFIITGAPIELLPYEDVTYWPEMQEILDWTETNVHSTMNVCWGAMAAIYHFHGVPKYELKEKAFGVYRHRNLKPSSIYLNGFSDNFEVPVSRWTEVRRDDIEKSDELEILMESSEMGVCLVHEKRGRRLYMFNHVEYDSTSLSDEYFRDVNTGVPIKMPHNYFPHNDPALAPQNRWRSHAHLLFGNWINEIYQTTPFDVEEIGMDL
What is the function of this protein?
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
What are the official names of this protein?
Homoserine O-acetyltransferase, HAT, Homoserine transacetylase, HTA.
What is the protein family that this protein belongs to?
Belongs to the MetA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IRTA_MYCTO
Sequence: MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQDAEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTVKPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQHDDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLRDEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQAASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVGFAAVGLLGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTLALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPRIVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTLMDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTGLLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRPGTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQLVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVLGANSGLSGGERQRLTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQIVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQDGTR
What is the function of this protein?
Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT).  Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell.  Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation.
What are the official names of this protein?
Mycobactin import ATP-binding/permease protein IrtA, Iron-regulated transporter A.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Siderophore-Fe(3+) uptake transporter (SIUT) (TC 3.A.1.21) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: V029_FOWPN
Sequence: MANVFDNSSYRDMLKMVFVIRDDLKMTKGEIVSQCCHGAISAYEKSKKYSPDYLKRWLKNGQVKETVKVDNENEMMDIRENATAIGVNYYIVQNDKRQKCNTVLVIGPAPNYMFESLTRSLKPL
What are the official names of this protein?
Putative peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH2 family.
Protein: STRA8_HUMAN
Sequence: MGKIDVDKILFFNQEIRLWQLIMATPEENSNPHDRATPQLPAQLQELEHRVARRRLSQARHRATLAALFNNLRKTVYSQSDLIASKWQVLNKAKSHIPELEQTLDNLLKLKASFNLEDGHASSLEEVKKEYASMYSGNDSFPQNGSSPWYLNFYKQTMDLLTGSGIITPQEAALPIVSAAISHLWQNLSEERKASLRQAWAQKHRGPATLAEACREPACAEGSVKDSGVDSQGASCSLVSTPEEILFEDAFDVASFLDKSEVPSTSSSSSVLASCNPENPEEKFQLYMQIINFFKGLSCANTQVKQEASFPVDEEMIMLQCTETFDDEDL
What is the function of this protein?
Meiosis-inducer required for the transition into meiosis for both female and male germ cells.  In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase.  During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation.  In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis.
What are the official names of this protein?
Stimulated by retinoic acid gene 8 protein homolog.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent.
Protein: YDGD_BACSU
Sequence: MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTVTGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICLIVSIMIIMGSYT
What are the official names of this protein?
Uncharacterized protein YdgD.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: G6PI_BUCAP
Sequence: MKNINLIETKSWKDLKNHFKEVKNIHLKDLFLSDFNRFKKFSIFFENEILIDFSKNRITEKTLILLLNLAKEMNVKSAIKLMFSGSKINQTENRSVLHIALRNRSNFPILLNNSDIMSEVNDVLKKMKNFSELVIDGTWKGYSGKSISDVVNIGIGGSDLGPYMVTEALRPYKNHLNIHYVSNIDGTHLSEILKKINPETTIFLIASKTFTTDETITNANSAKFWFLKHSKTKETLDKHFFALSANINNAVNFGINIKNIFQFWDWVGGRFSLWSSAGLSIVLSIGFNNFEKFLQGAHVMDNHFYHTEYDKNIPILLALISIWYTNFFNSETEAIFPYDQYMHRFSAYFQQSNMESNGKSIDKNGNKVCYQTGPIIWGEPGTNGQHAFFQLIHQGTKLIPSDFIVPTVSHNNLNDHHLKLISNFLAQTQVLAFGKSKNSFLKESTSFKKEEDEFNRILPFKICEGNKPTNSILLRKITPYTLGMLIALYEHKIFVQGHILNIFSFDQWGVEIGKEVAQSIYKNINEKTKNSKSYDSSTQGLIDFYNFFKNKQNYL
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: D131A_HUMAN
Sequence: MRVLFFVFGVLSLMFTVPPARSFISNDECPSEYYHCRLKCNADEHAIRYCADFSICCKLKIIEIDGQKKW
What is the function of this protein?
Has antibacterial activity (Probable).  Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion (PubMed:26649771).
What are the official names of this protein?
Beta-defensin 131A, Beta-defensin 31, DEFB-31, Defensin, beta 131.
What is the protein family that this protein belongs to?
Belongs to the beta-defensin family.
What are the subcellular locations of this protein?
Secreted.
Protein: ATP6_BORPD
Sequence: MAAASDVSPQSAYIQHHLVHLNNIGEKQSVIAQFNVINYDSVFWSALTGLVVVLFLWLAARRASAGVPGRFQAFVEMIVDMVDEQAKGIVTNAKSRLFVAPLALTVFLWIILMNALDLIPVDLMPTVWRWTGLGAHHGDPLYYHRILPTADLNVPMGMSLGVLLLMFYYGIKIKHPGGFVKELFTAPFHAHGIAALFLAPANLLLNLIEYAAKSVSLGMRLFGNMFAGELVFMLIALLGGAWTGLNAASVGLGIGHVLAGSVWAIFHILIVLLQAFIFMMLTLVYIGQAHEGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: TBB_ASPFL
Sequence: MREIVHLQTGQCGNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVVDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATYSVVPSPKVSDTVVEPYNATLSVHQLVEHSDETFCIDNEALYDICMRTLKLSNPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVSVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGKVSMKEVEDQMRNIQSKNQTYFVEWIPNNIQTALCSIPPRGLKMSSTFIGNSTSIQELFKRVGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDASISEGEEEYLEEEEPLEHEE
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin beta chain, Beta-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: DRE4_SCHPO
Sequence: MSQPLPPGWTEHKAPSGIPYYWNAELKKSTYQRPSFIEKNHSSSVTASQASLAFNTSEKLFVNENAEERKNSRDLRKQLPDRPKFKKRIPNNDSWVVVFTKKNRYFFHNLKSHESYWEPPLEISKDLKILRLPIRKQISKDSSQSQNVDSGKTNHEEIHESRHLQTEIEEPSGLEESSEESVLYSEEFYEKSDEEEDEEKSHSAEELEFGEEDIMYQLQQLDDETVSYDIQEQATNLSTDDARRVFTELLKDKNIGAYQPWELVYPKLLDDDRFYVLDSGERRKEVFEEYCKSVVSTKKITRRKNTLSDFWTLLHSLPSTLLWPQFKRKYRKSSTLQIPGYSERDFEKLFREFQILRKQPMQDKLLNFKKLCKSKTVDPKNPDEFTESILNDTRYAVLTREELDSLACSSN
What is the function of this protein?
Component of the spliceosome involved in mRNA processing.
What are the official names of this protein?
Pre-mRNA-splicing factor dre4, DNA replication protein 4, Hyphal growth protein 1.
Protein: PHOU1_MYCTO
Sequence: MRTVYHQRLTELAGRLGEMCSLAGIAMKRATQALLEADIGAAEQVIRDHERIVAMRAQVEKEAFALLALQHPVAGELREIFSAVQIIADTERMGALAVHIAKITRREYPNQVLPEEVRNCFADMAKVAIALGDSARQVLVNRDPQEAAQLHDRDDAMDDLHRHLLSVLIDREWRHGVRVGVETALLGRFFERFADHAVEVGRRVIFMVTGVLPTEDEISTY
What is the function of this protein?
Plays a role in the regulation of phosphate uptake.  In this role, it may bind, possibly as a chaperone, to PhoR, PhoP or a PhoR-PhoP complex to promote dephosphorylation of phospho-PhoP, or inhibit formation of the PhoR-PhoP transitory complex (By similarity).
What are the official names of this protein?
Phosphate-specific transport system accessory protein PhoU homolog 1, Pst system accessory protein PhoU homolog 1.
What is the protein family that this protein belongs to?
Belongs to the PhoU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DTD_XANC8
Sequence: MLALIQRVTRASVAVDAQVVGQIGPGLLALIGIEPGDTAPQLRRLAERLLGYRVFSDEAGKMNRSLADTGGGLLLVSQFTLAADTKAGMRPSFSTAAPPEEAERAFNQLVAICREKHSGGVETGRFGAHMVVDLVNDGPVTFLLRP
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEPF_THEPX
Sequence: MSSKMIDKLMSFFGIDEPEEEKEEVDSLQPVIPYDRKPKIVNIHTQPQVKVLILKPEKFEQVMNICNELKNKKPVIVDLQKMDKNEAQRVVDFLSGAAYALNGEIKKISGYIFLVAPENFDITGDIKDEVNSLYNLN
What is the function of this protein?
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring.  Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments.  Its function overlaps with FtsA.
What are the official names of this protein?
Cell division protein SepF.
What is the protein family that this protein belongs to?
Belongs to the SepF family.
What are the subcellular locations of this protein?
Cytoplasm. Note=Localizes to the division site, in a FtsZ-dependent manner.
Protein: ADDB_STRSV
Sequence: MKLLYTDIRHSLTKVLVAEAESLVAAGKRVFYIAPNSLSFEKERSVLECLKTQASFAITVTRFAQMARYFVLNDVRQGQSLDDIGLGMLIYRTLTELDDGELKVYSRIKKDPQFIQQLMDLYHELQTAQMSFADLEFLEEPEKREDLVKIFTAVTAALNKGDFDSSSQIAAFAQHILAGDTDEELADLALVIDGFTRFSAEEEYLVGLLHRKGVEIVIGTYASQKAYRAAFREGNLYQASVDFLRKLAEDYQVKPDYIPHAEAEDAFGRISKILESRYDFSESTVSLSESDRSQLQIWATMNQKEELEYVAKSIRQRVHEGVRYKDIRLLLGDVEAYQLQLKTIFDQYQIPYYLGRSESMAQHPLVQFVESLERLKRYNFQLEDLLNLLKTGLYGDLTQEELDHFEQYLRFADIKGAGKLAKDFTANSQGKFDLDCLNHIRRRVMTPLQDFFKSRSQTASGLLAKFTEFVQAARLSDNLTALLQGESQQEQERHEEVWKAFSHVLEQFAQVFADSKVKLDDFLALVLSGMLLSNYRTVPATVDVVKVQSYDLIEPLAAPYVYAIGLTQERFPKIAQNKSLLSDEDRARLNDATDSQAELQIASSENLKKNRYTALSLMNSATKELVLSAPALVNEVEDSMSTYLLELTAAPLSLPIIVKKPQASSDDIGSYRALLSQIIELHQEEIDREWTAEEQTFWAVAVRVLRKKLAAEGISIPHISKELKTETLQSETLQALYPQEQPLRLSASALNEYFRHQYAYFLKYVLRLQEEWTIHPDARSHGIFLHRIFEKVLQDDSSADFDRRLAQAMEETSREAEFESIYSESGQTRFARQLLLDTARATGRVLAHPSGIETIGEETGFGSASTPFLTLENGRAVTVSGKVDRIDRLTKTESLGVVDYKSGDIKFSFEKFFNGLNSQLPTYLAAIEELADYQEDKGTFGAMYLQMTDPIVALKDTKTLADAVSQSMKPLQYKGLFVADAVKELGPLYEKNKTNLLSQEDLDLLLAYNAYLYKKAAEGILSGHFAVNPYTENGRSIAPYVEQFKAITGFEANLHLGQARQLEKLDASKFDRRPTGDKLRQAWLEKMREEMEK
What is the function of this protein?
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease.  Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination.  This subunit has 5' -> 3' nuclease activity.
What are the official names of this protein?
ATP-dependent helicase/deoxyribonuclease subunit B, ATP-dependent helicase/nuclease RexB.
What is the protein family that this protein belongs to?
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Protein: RS7_PSYA2
Sequence: MPRRRVVATREILPDPKFGSQTVAKFINHVMSHGKKSTAERIVYGALETVSQKRNIEDPVSFFEDVLENVRPMVEVKARRVGGATYQVPMEVRPSRRTALAMRWLAEAAAKRSEKSMALRLAGELNDAADGKGNAMKKRDEVHRMADANKAFSHYRF
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
What are the official names of this protein?
30S ribosomal protein S7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: NB5R4_HUMAN
Sequence: MLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTELFDQVHRWVNYESMLKECLVGRMAIKPAVLKDYREEEKKVLNGMLPKSQVTDTLAKEGPSYPSYDWFQTDSLVTIAIYTKQKDINLDSIIVDHQNDSFRAETIIKDCLYLIHIGLSHEVQEDFSVRVVESVGKIEIVLQKKENTSWDFLGHPLKNHNSLIPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPSTHLQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYFLIKIYPTGLFTPELDRLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGTGFTPMVKILNYALTDIPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKDKRLDVEFVLSAPISEWNGKQGHISPALLSEFLKRNLDKSKVLVCICGPVPFTEQGVRLLHDLNFSKNEIHSFTA
What is the function of this protein?
NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway.  Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS).  Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
What are the official names of this protein?
Cytochrome b5 reductase 4, Flavohemoprotein b5/b5R, b5+b5R, N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein, cb5/cb5R.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Note=Soluble protein.
Protein: ABHGB_MOUSE
Sequence: MCVICFVKALVHVFKIYLTANYSYNFRSWPVDFRWDDLHAPSTGNSSQRALTCAAAAAGVWLLHDAALGGDTLTRPPRGARSQVQCLLQQIRELPSQLASYALAHSLGRWLVYPGSMFLMTRALMPLLQQGQERLVDRYRGRRAKLVACDGNEIDTMFMDRRQHPGSHGRGLCLVICCEGNAGFYEMGCLSAPLEAGYSVLGWNHPGFGGSTGAPFPQHDANAMDVVVKYALHRLNFPPAHVVVYGWSIGGFTATWATMTYPELGALVLDATFDDLVPLALKVMPQSWKGLVVRTVREHFNLNVAEQLCCYPGPVLLLRRTQDDVVSTSNHIPSMPSCQVEGDVEGNRGNELLLRLLQHRYPSVMAREGRTVVTRWLRASNLAQETALYARYRVDDEWCLATLRSYRERCQKELDDAEAWGPHGLSFPWFVGQGLSARRRRQLALFLARRHLKNLEATHCSPLEPEDFQLPWRL
What are the official names of this protein?
Protein ABHD16B, Alpha/beta hydrolase domain-containing protein 16B, Abhydrolase domain-containing protein 16B.
What is the protein family that this protein belongs to?
Belongs to the AB hydrolase superfamily. ABHD16 family.
Protein: DRG2_ARATH
Sequence: MGIVERIKEIEAEMARTQKNKATEYHLGQLKAKIAKLRTQLLEPPKGSSGGGDGFEVTKYGHGRVALIGFPSVGKSTLLTMLTGTHSEAASYEFTTLTCIPGVIHYNDTKIQLLDLPGIIEGASEGKGRGRQVIAVAKSSDLVLMVLDASKSEGHRQILTKELEAVGLRLNKRPPQIYFKKKKTGGISFNTTTPLTRIDEKLCYQILHEYKIHNAEVLFREDATVDDFIDVVEGNRKYIKCVYVYNKIDVVGIDDVDRLARQPNSIVISCNLKLNLDRLLARMWDEMGLVRVYSKPQSQQPDFDEPFVLSADRGGCTVEDFCNQVHRTLVKDMKYALVWGTSARHYPQHCGLFHHLEDEDVVQIVKKKVREEGGRGRFKSHSNAPARIADREKKAPLKQ
What is the function of this protein?
Binds GDP and GTP, and has low GTPase activity.
What are the official names of this protein?
Developmentally-regulated G-protein 2, AtDRG2, Developmentally-regulated G-protein 2B, AtDRG2b.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1177_PECCP
Sequence: MKTKLNELLEFPCVFTYKVMGEAKPELVDLVVEVVQRHAPGDYTPQIKPSSKGNYHSVSITITATHIEQVETLYEELGNIDIVRMVL
What are the official names of this protein?
UPF0250 protein PC1_1177.
What is the protein family that this protein belongs to?
Belongs to the UPF0250 family.
Protein: NADD_BORBU
Sequence: MRIAILGGTYNPVHIGHIFLAKEIEYLLNIDRVIFIPTCNPAHKLIDENVSVSNRIDMLKLALENEDKMFIDDCDIINGGITYTVDTISCVKKKYKNDKLFLIIGDDLFQNFDSWKDPQSIVSSVELVVAHRIYKERLKSSFKHIYIDNKIIPISSSEIRNRIVNGLPVSYLLPFGVLKYIKDNNLYVKKVNV
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: PTGDS_MACFU
Sequence: MATHHTLWMGLVLLGLLGGLQAAPEAQVSVQPNFQPDKFLGRWFSAGLASNSSWLQEKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPGESLGSYSYGSPHWGSTYSVSVVETDYDHYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFSAFCKAQGFTEDSIVFLPQTDKCMTEQ
What is the function of this protein?
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation.  Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes.  Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter.  Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier.  It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity).  Involved in PLA2G3-dependent maturation of mast cells.  PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).
What are the official names of this protein?
Prostaglandin-H2 D-isomerase, Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2.
What is the protein family that this protein belongs to?
Belongs to the calycin superfamily. Lipocalin family.
What are the subcellular locations of this protein?
Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.
Protein: CP1A2_MOUSE
Sequence: MAFSQYISLAPELLLATAIFCLVFWMVRASRTQVPKGLKNPPGPWGLPFIGHMLTVGKNPHLSLTRLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVRQGDDFKGRPDLYSFTLITNGKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSASSCYLEEHVSKEANHLVSKLQKAMAEVGHFEPVSQVVESVANVIGAMCFGKNFPRKSEEMLNIVNNSKDFVENVTSGNAVDFFPVLRYLPNPALKRFKTFNDNFVLFLQKTVQEHYQDFNKNSIQDITSALFKHSENYKDNGGLIPEEKIVNIVNDIFGAGFDTVTTAITWSILLLVTWPNVQRKIHEELDTVVGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPFTIPHSTTRDTSLNGFHIPKERCIYINQWQVNHDEKQWKDPFVFRPERFLTNNNSAIDKTQSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLQHLEFSVPPGVKVDLTPNYGLTMKPGTCEHVQAWPRFSK
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2.  Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis.  May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver.  Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid.  Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer.  Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA.  May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).  Plays a role in the oxidative metabolism of xenobiotics.  Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.  Metabolizes caffeine via N3-demethylation.
What are the official names of this protein?
Cytochrome P450 1A2, CYPIA2, Cholesterol 25-hydroxylase, Cytochrome P450-P2, Cytochrome P450-P3, Hydroperoxy icosatetraenoate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: CENPP_MOUSE
Sequence: MDSETRELRALEAEVAALQRECRMLQNAGEKASGAWKSFQKISQSDSEEWESLKDLRSQLEHLRSEHSFLSKLTGFNIRNYSKMEDIVNTEETEKDTKKVLQKHRLSGNCNMVTFQLEFEVLEMETKEKKSSIITDLSIIMEPTEYSELSEFASRAEEKRDLLMFFRSLHFFVEWCEYRENTFKHFKEKYPDTVYLLEGTCSHCMEIRSTRQPGFELVIVWKIQIDEEGMVFPKLDLLTKVPERALGLDKNRVIETAPLSFRSLLGVLGIEAALDSLIRLFSGDNN
What is the function of this protein?
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.  May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity).
What are the official names of this protein?
Centromere protein P, CENP-P.
What is the protein family that this protein belongs to?
Belongs to the CENP-P/CTF19 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity).