PharMolix/UniProtQA huggingface dataset:
Protein: SSRP_CLOP1
Sequence: MAKRKDNKTLAENRKARHDYFVDEAMEAGIALVGTEVKSIRNGRVNLKDCYADINNGEIFINNMHISPYEQGNIFNVDPLRKRKLLLHKSEIQRLIGIVQQQGVALIPLSLYLKNGRVKVNLGVCRGKKNYDKRDTMLEKAHKREMDRQLKERNRY
What is the function of this protein?
Required for rescue of stalled ribosomes mediated by trans-translation.  Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes.  tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB.  tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame.  During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA.  The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation.  The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
What are the official names of this protein?
SsrA-binding protein, Small protein B.
What is the protein family that this protein belongs to?
Belongs to the SmpB family.
What are the subcellular locations of this protein?
Cytoplasm. Note=The tmRNA-SmpB complex associates with stalled 70S ribosomes.
Protein: MRAY_XYLFT
Sequence: MLFEFARWLQQFESLFGLFNYLTFRSILAALTALFLSLWIGPVLIQKLSQFKGGQPIRQDGPKMHFSKAGTPTMGGSLILMTVTLSVLLWGDLRNRYVWLVLVVMLAFGAIGWYDDWIKLARRDPNGLKSRWKYLLQSIFGLAAGLFLYFTADVPAAVTFYIPMFKSIALPLTSISFVAITYFWIVGFSNAVNLTDGLDGLAIMPTVLVACALGVFAYASGNTLFSSYLKIPTIPGAGDLIIICAAIAGAGLGFLWFNAYPAMVFMGDIGALALGAVLGTIAVIVRQELVLVVMGGVFVIETLSVIIQVTSFKLTGKRVFRMAPIHHHFELKGWPEPRVIVRFWIISVVLVLVGLATLKVR
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HBB_SAISC
Sequence: MVHLTGDEKAAVTALWGKVNVEDVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMNNPKVKAHGKKVLGAFSDGLAHLDNLKGTFAQLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPQVQAAYQKVVAGVANALAHKYH
What is the function of this protein?
Involved in oxygen transport from the lung to the various peripheral tissues.
What are the official names of this protein?
Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain.
What is the protein family that this protein belongs to?
Belongs to the globin family.
Protein: MOB2_DROME
Sequence: MNWAISNLTGGNRVSRAILVRYSSVPLADATNDGSSTAPQTPTASTPRPSSSHSSLSSTFAATFLHASSRHIPGRAVPRQNANGQNGGKGNASGAGGGAGGGGAGGASGGTGGTGAQAAGQLSLPLDVEETVTCFCRKARRKERDGDQNSTDTKLYLEESVLERKLPEADLKALVDLPAGLDYNEWLASHTLALFEHVNLVYGTISEFCTQSGCADMTGPGNRTYLWFDEKGKKTRVAAPQYIDYVMTFTQKTVSDESIFPTKYANEFPGSFESIARKILRLQFHVIAHLYAAHFREIALLGLHTHLNLTFAHLTALHRRFNLIDEKETDVLRDLEVALRLTDDTGGCQDATSTTSSVHDHSHSGDLQHQSLQQQQQHHNSSSNSTSSAEAFHVNSQSNNGSTSASASVSLIDGDAVAPPICTQPEAGAGCKPAGSSGLLGGILGDLTSGEFGDTTRYCTSAVPQAAAAAGAGVGGTAIGATDAAALNNGAGALHLNFSNNNNNNHNLNHHHHHHHHHGHHGHHHAAQQQQQHSGLIQCNAAGGGGNATGVATGGATAAASSTTTA
What is the function of this protein?
Required for the normal morphogenesis of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites.
What are the official names of this protein?
MOB kinase activator-like 2, Mob as tumor suppressor protein 2, Dmob2, Mps one binder kinase activator-like 2.
What is the protein family that this protein belongs to?
Belongs to the MOB1/phocein family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Note=Trc colocalizes with Mob1 to the cell periphery in wing cells and wing hairs.
Protein: NU6M_RAT
Sequence: MTNYMFILSLLFLTGCLGLALKPSPIYGGLGLIVSGCIGCLMVLGFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNWFIFSFFVLGLFMELVVFYLFSLNNKVELVDFDSLGDWLMYEIDDVGVMLEGGIGVAAIYSCATWMMVVAGWSLFAGIFIIIEITRD
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.  Essential for the catalytic activity and assembly of complex I.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 6, NADH dehydrogenase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 6 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RS18_ALISL
Sequence: MARFFRRRKFCRFTAEGVQEIDYKDVATLKNYITEAGKIVPSRITGTRAKYQRQLARAIKRSRYLALLPYTDKHL
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: MGMT_RAT
Sequence: MAEICKMKYTVLDSPLGKIELSGCERGLHGIRFLSGKTPNTDPTEAPACPEVLGGPEGVPEPLVQCTAWLEAYFHEPAATEGLPLPALHHPVFQQDSFTRQVLWKLLKVVKFGEMVSYQQLAALAGNPKAARAVGGAMRSNPVPILIPCHRVIRSDGAIGNYSGGGQTVKEWLLAHEGIPTGQPASKGLGLIGSWLKPSFESSSPKPSG
What is the function of this protein?
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA.  Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme.  This is a suicide reaction: the enzyme is irreversibly inactivated.
What are the official names of this protein?
Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase.
What is the protein family that this protein belongs to?
Belongs to the MGMT family.
What are the subcellular locations of this protein?
Nucleus.
Protein: COMCA_BPT4
Sequence: MAIKFEVNKWYQFKNKQAQENFIKDHTDNGIYARRLGMEPFKILDADYLGRPTKIMTSIGVLKRCAGGDILDENFIWLSTNEAGFFDEVENPYQAVEEQEQEEKEQEQIEDFTEFPVMKVTIENNDQAWSLYQMLKAYFKE
What is the function of this protein?
Plays a role in the expression of some T4 genes involved in DNA synthesis including the helicase/primase gp41.  May act as a transcriptional antitermination factor.
What are the official names of this protein?
Protein comC-alpha.
Protein: NADB_LISMO
Sequence: MIKERVIIVGSGISGCTAALRLMQDYDVTIITKGYKEESNSMLAQGGVAAAVSKNDTPKKHFSDTFQAGCFHNKVLAVNQLVTHGPMVIQKLIAEGMAFDEQDGELALGLEGAHQLPRILHTGGDQTGKFLTTFLQEKLTDIHWQEQKMAIEIIKQNDSAIGVHCLDKENRLHTYYGEHIILASGGLGQLFPVTTNAATISGDGLALAYRAGAKLTDMEFIQFHPTLLFLNGRCHGLISEAVRGEGAKLIRADGSAIMTDVHPRADLAPRDIVAATLFAEIQDGNEVFLDITAIPNFEKRFPGITANLDAHHIPFRETKRIPVHPGAHFLMGGIRTDLSGKTNIPGLYAIGEVANAGVHGANRLASNSLLETLVFGEKVAEYIRTQKINPIDHPEIPLSNQIQTPHLPDKQLLQEKIWETLGITRKPEKITEFLHWLTDFDYANHTRKTAEISHMLITAKLIAESALKRTESLGAHRILKGVIK
What is the function of this protein?
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
What are the official names of this protein?
L-aspartate oxidase, LASPO, Quinolinate synthase B.
What is the protein family that this protein belongs to?
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TPIS_BORGP
Sequence: MRKTFLAGNWKMHYTSTEASIVAKKIATEVKTLKDDFVIMITPPFTALSKVSECIKGSNILLGAQNMSYMESGARTSEISPSMLLEFGVEYVILGHSECRLYLGETDEIINKKILTGLKHPFKYLILCVGETLNERDSEKTLDVVLNQVKKGLDGVSESDIKRIILAYEPIWAIGTGKTATKEEAEEVHKAIRLEIMKLYSKSVSDNVIIQYGGSVNSSNVKELMNEPDIDGALIGGASLKAESFLSIINNVL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
What are the official names of this protein?
Triosephosphate isomerase, TIM, TPI, Triose-phosphate isomerase.
What is the protein family that this protein belongs to?
Belongs to the triosephosphate isomerase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS7_PSEA6
Sequence: MSLSQQAILFIDRDGTLVEEPPIDKQLDTLAKLVFEPMVMPVLTQLQNAGFRLVMVSNQDGLGTDSFPQVDFDLPHNKMMDIFASQGIVFDDVLICPHFPEDNCTCRKPNLGLVKDYLQQGKIDFTRSFVIGDRETDIQLAQNMGIVGIRYDRDAKDWPAIAKQLLASSRIAEVVRKTSETDIHVKVDLDSQAKSTIETGIGFFDHMLDQIATHGGFELNLRVDGDLHIDDHHSVEDTALALGEALKKALGDKRGIGRFGFALPMDECRAECILDISNRPHLKFEAEFSRDTVGEMATEMVPHFFYSIAQAMGLSLHLSTSEGNAHHQVESLFKVFGRALRQAIQKNGEALPSSKGTL
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisB.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALG10_CANAL
Sequence: MPLIIPSNDIYISIISKYVAIVIFLIFVIIMFNNITHHLTQPYIDEIFHLRQCQTYCQYNFHHWDNKITTPPGLYILGFIYSEGIKILTRSSSTGGGGGGGHLTCFNDNVLRSINLIGGVVILPRILQQFHNGWSKNSKNQFFWSINIISQPLLFTYYFLFYTDVSSTILIILSLGLINYKLLQYPMLSALVGFMSLWFRQTNIIWIAFIASIFIDRQIKIKTGVIDRIRQFIMKSLTNWNKLLGYIVNIILFVIFLKLNGGITLGDNDNHQIELHIVQVFYCFTFITFFTIPNWLNKSTIKKYYNFIINHIILNLVIGLIIWYIMENFTIVHPFLLADNRHYAFYIYKRLLSQSYLKPLILMAYHFSSFQIISSLIKGGQLSFIGIFSYLIAVGLTLIPSPLFEPRYYITPLIIFNLYINHPHNLLEFIWLNSINLITSYIFLHKGIIW
What is the function of this protein?
Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation.  Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
What are the official names of this protein?
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Alpha-1,2-glucosyltransferase ALG10-A, Alpha-2-glucosyltransferase ALG10, Asparagine-linked glycosylation protein 10, Dolichyl-phosphoglucose-dependent glucosyltransferase ALG10.
What is the protein family that this protein belongs to?
Belongs to the ALG10 glucosyltransferase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TSAC_THIDA
Sequence: MSTAESREGAQPGLHAYLRRGGVIAYPTESCYGLGCDPRNAAALRRLIRLKGRDAGKGMLLIADRYRRLQPFVGALSPTGRARMRRSWPGPVTWVVPASRRCPPELTGGRTTVAVRVTAHRPAAALCRSLGTALVSTSANKSGHTPAKTAAQCRRMFGARVRVVDGRIGTRRRPSTLIDLATGKILRA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
What are the official names of this protein?
Threonylcarbamoyl-AMP synthase, TC-AMP synthase, L-threonylcarbamoyladenylate synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC, tRNA threonylcarbamoyladenosine biosynthesis protein TsaC.
What is the protein family that this protein belongs to?
Belongs to the SUA5 family. TsaC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROA_XYLFT
Sequence: MYCRRSQLKKPSMSHRTHYYWIAHQGTPLHGVLSIPGDKSISHRAVMFAALADGTSRIDGFLEAEDTRSTAAILARLGVRIETPSFTQRIVHGVGVDGLQASDIALDCGNAGTGMRLLAGLLVAQPFDSVLVGDASLSKRPMRRVTDPLSQMGARIDTSDDGTPPLRIYGGQLLRGIDFISPVASAQIKSAVLLAGLYARNETVVREPHPTRDYTERMLTAFGVDIDVSTGCVRLRGGQRLCATNITIPADFSSAAFYLVAASVIPGSDITLRAVGLNPRRIGLLTVLRLMGADIVESNRHEQGGEPVADLRVRYASLQGTRVPEDLVPDMIDEFPALFVAAAAAEGQTVVSGAAELRVKESDRLAAMVTGLRVLGVQVDETADGATIHGGPIGHGTINSHGDHRIAMAFSIAGQLSVSTVRIEDVANVATSFPDYETLARSAGFGLEVYCDPA
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCGL_SHIFL
Sequence: MPKPGILKSKSMFCVIYRSSKRDQTYLYVEKKDDFSRVPEELMKGFGQPQLAMILPLDGRKKLVNADIEKVKLALTEQGYYLQLPPPPEDLLKQHLSVMGQKTDDTNK
What are the official names of this protein?
Protein YcgL.
Protein: GUN_CLOSA
Sequence: MFSKIKKINFFKKTFSFLIAVVMMLFTVLGTNTYKAEAATTSFGGQLKVVGSQLCDSNGKPIQLKGMSSHGLQWYVNFVNYDSMKFLRDKWGVNVIRAAMYTNEGGYISNPSSQKEKIKKIVQDAIDLNMYVIIDWHILSDNNPNTYKEQAKSFFQEMAEEYGKYSNVIYEICNEPNGGTNWANDIKPYANYIIPAIRAIDPNNIIIVGTSTWSQDVDIAADNPLRYSNIMYTCHFYAGTHTQSLRDKINYAMSKGIAIFVTEWGTSDASGNGGPYLDESQKWVDFMASKNISWTNWALCDKSEASAALKSGSSTTGGWTDSDLTTSGLFVKKSIGGSNTTSQTSAPTFSLQSGTYDSAQTVTLTSSDNDSVIHYTTDGTTPTSSSPVYTSPITISKTTTVKAFTTKTGMTDSNITSAVYTISNTDPVKQVSAPTFSYNQEHTIQLKL
What are the official names of this protein?
Endoglucanase, Cellulase, Endo-1,4-beta-glucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 5 (cellulase A) family.
Protein: 12KD_MYCSM
Sequence: MFHVLTLTYLCPLDVVXQTRPAHV
What are the official names of this protein?
12 kDa protein.
Protein: NADA_MYCSK
Sequence: MTLLDETASAQFGDDVAPTEEWAAEVRRLARQRGATLLAHNYQLPAIQDVADHVGDSLALSRIAAEAPEDTIVFCGVHFMAETAKILSPDKTVLIPDARAGCSLADSITADQLREWKAEYPGAVVVSYVNTTAAVKAETDICCTSSNAVDVVASIPADREVLFCPDQFLGAHVRRVTGRTNMQIWAGECHVHAGINGDELADQARAHPDAELFVHPECGCATSALYLAGEGAFPADRVKILSTGGMLDAARESRASQVLVATEVGMLHQLRRAAPEIDFQAVNDRASCRYMKMITPAALLRCLTYGTDEVDVDHETARLARRSVQRMIEIGQPGGGE
What is the function of this protein?
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
What are the official names of this protein?
Quinolinate synthase.
What is the protein family that this protein belongs to?
Belongs to the quinolinate synthase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TMM33_HUMAN
Sequence: MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQALLEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDARGSNSLPLLRSVLDKLSANQQNILKFIACNEIFLMPATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRTLFNELRIVVEHIIMKPACPLFVRRLCLQSIAFISRLAPTVP
What is the function of this protein?
Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis.  Mechanistically, stimulates PKD2 calcium-dependent activity (By similarity).  Suppresses the RTN3/4-induced formation of the ER tubules (PubMed:25612671).  Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling (PubMed:26268696).  Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis (PubMed:30760708).  Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325).  Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM.  Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane (PubMed:34487377).
What are the official names of this protein?
Transmembrane protein 33, Protein DB83, SHINC-3.
What is the protein family that this protein belongs to?
Belongs to the PER33/POM33 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Melanosome. Nucleus envelope. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Co-localizes with RTN4 at the ER sheets.
Protein: DEF_LEPBL
Sequence: MSVRKILRMGDSILRQVSIPVTENELQTKEFKKLIRDMFDTMRHAEGVGLAAPQIGILKQIVVVGSEDNERYPDTPNVPERVILNPIITPLTKDTSGFWEGCLSVPGMRGYVERPNKIRMQWMDEKGDRFDETIDGYKAVVYQHECDHLSGILYVDRLKDTKLFGFNDTLDSGRNVLD
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: RL1_HELPH
Sequence: MAKKVFKRLEKLFSKIQNDKAYGVEQGVEVVKSLASAKFDETVEVALRLGVDPRHADQMVRGAVVLPHGTGKKVRVAVFAKDIKQDEAKNAGADVVGGDDLAEEIKNGRIDFDMVIATPDMMAVVGKVGRILGPKGLMPNPKTGTVTMDIAKAVSNAKSGQVNFRVDKKGNVHAPIGKASFPEEKIKENMLELVKTINRLKPSSAKGKYIRNAALSLTMSPSVSLDAQELMDIK
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: ARGC_YERPE
Sequence: MLNTLIVGASGYAGAELTAYLNRHPHMNITGLAVSAQSADAGKLLSDLHPQLKGILDLPLQPLVDVAQAAKGIDVVFLATAHEVSHDLAPQFLAAGCVVFDLSGAFRVRDAAFYSQYYGFEHQHPDWLDKAVYGLAEWQSEDIKQAQLIAVPGCYPTASQLALKPLVDGQLLNDAQWPVINAVSGVSGAGRKASMGNSFCEVSLQPYGLFTHRHQPEIVTHLGTPVIFTPHLGNFARGILATITCRLKAGVTAQNIADAYHHAYQNKPLVRLYQQGVPALKAVVGLPFCDIGFSVQGEHLIIVATEDNLLKGAAAQAVQCMNIRFGFPETQSLL
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
What are the official names of this protein?
N-acetyl-gamma-glutamyl-phosphate reductase, AGPR, N-acetyl-glutamate semialdehyde dehydrogenase, NAGSA dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: VATC_ARCFU
Sequence: MITMIYKGNRAAWAYIVARTKVMKSRLLKPEDFRKLLNMEFDEIVRYIGETEYKKEIDELGYKFTGPRLLDHALYANLARTYRKLIEVSFGASKFLIMKYLEKWDVWNIINIIRGKMANVQPEVVDDILVPAGERDMDFWKTLLVKDIEEIVKSFEGTPYYEPLSKIGSEDMSKIEDGLYKVYYRELLKLNPSDFAMKLFLDFIKMEIDIRNVKTLLRLKAEDATPDEIMECTIPGGYELTEEELRKLAAMPIDEMIKALEGYWFWNDVQIEGKEVAAVEIEFDKVWIKTISKRASNYPLSILPVLQYIVLKKVEVDNLRVLGWGKYYGLPSEEIERQMVIL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
V-type ATP synthase subunit C, V-ATPase subunit C.
What is the protein family that this protein belongs to?
Belongs to the V-ATPase V0D/AC39 subunit family.
Protein: LY6S_HUMAN
Sequence: MSSLQAMKTLSLVLLVALLSMERAQGLRCYRCLAVLEGASCSVVSCPFLDGVCVSQKVSVFGSKVRGENKLSLLSCQKDVGFPLLKLTSAVVDSQISCCKGDLCNAVVLAASSPWALCVQLLLSLGSVFLWALL
What are the official names of this protein?
Lymphocyte antigen 6S.
Protein: MBD3_MOUSE
Sequence: MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEEEEEEEEEEEEPEPERV
What is the function of this protein?
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity).  Acts as transcriptional repressor and plays a role in gene silencing (By similarity).  Does not bind methylated DNA by itself (PubMed:9774669).  Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity).  Recruits histone deacetylases and DNA methyltransferases (By similarity).
What are the official names of this protein?
Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci.
Protein: BG3_ARATH
Sequence: MKMCNGSSFLASLPLLLLLLSFILASFFDTAVGQIGVCYGRNGNNLRPASEVVALYQQRNIRRMRLYDPNQETLNALRGSNIELVLDVPNPDLQRLASSQAEADTWVRNNVRNYANVTFRYISVGNEVQPSDQAASFVLPAMQNIERAVSSLGIKVSTAIDTRGISGFPPSSGTFTPEFRSFIAPVISFLSSKQSPLLVNNYPYFSYTGNMRDIRLDYTLFTAPSTVVNDGQNQYRNLFHAILDTVYASLEKAGGGSLEIVVSESGWPTAGGAATGVDNARTYVNNLIQTVKNGSPRRPGRATETYIFAMFDENSKQGPETEKFWGLFLPNLQPKYVVNFN
What is the function of this protein?
May play a role in plant defense against pathogens.
What are the official names of this protein?
Probable glucan endo-1,3-beta-glucosidase BG3, Beta-1,3-glucanase 3, AtBG3.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum. Secreted.
Protein: PURA_FUSNU
Sequence: MAGYVVVGTQWGDEGKGKIIDVLSEKADYVVRFQGGNNAGHTVVVNGEKFILQLLPSGVLQAGTCVIGPGVVVDPKVFLDEIDRIEKRGAKTDHVIISDRAHVIMPYHIEMDKIRESVEDRIKIGTTKKGIGPCYADKIARDGIRMSDLLDLKQFEEKLRANLKEKNEIFTKIYGLEPLDFDKIFEEYKGYIEKIKHRIVDTIPIVNKALDENKLVLFEGAQAMMLDINYGTYPYVTSSSPTLGGVTTGAGVSPRKINKGIGVMKAYTTRVGEGPFVTEIKGEFGDKIKGIGGEYGAVTGRPRRCGWLDLVVGRYATEINGLTDIVITKIDVLSGLGKLKICTAYEIDGKVYDYVPADTKSLDKAIPIYEELDGWDEDITQIKKYEDLPVNCRKYLERVQEILACPISVVSVGPDRSQNIHIREI
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IBPL1_BOVIN
Sequence: MPRSPGLFLLLLVLQPLPALGLGLRSAGGRNPECGPCRPERCPEPVRCPVPGIVARDECGCCALCLGAEGASCGGRAGARCGPGLVCASRAAGAAPEGTGLCVCAQRGSVCGSDGRSYPSVCALRLRARQAPRALPGHLHKARDGPCEFAPVVITPPQSVHNVTGAQVYLSCEVRAVPTPVVTWRKVTRSPEGTQVMEELPGDHTNIAVQVQGGPSDHEATAWVLINPLRKEDEGVYQCHSANAVGEAQSHGTVTVVDRSQYRAPRFPAPDDRL
What is the function of this protein?
IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture.  They alter the interaction of IGFs with their cell surface receptors (By similarity).
What are the official names of this protein?
Insulin-like growth factor-binding protein-like 1.
What are the subcellular locations of this protein?
Secreted.
Protein: DPS_SALG2
Sequence: MSTAKLVKTKASNLLYTRNDVSESDKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALTDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAVVANDVRKAIGEAKDEDTADIFTAASRDLDKFLWFIESNIE
What is the function of this protein?
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages.  It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction.  One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
What are the official names of this protein?
DNA protection during starvation protein.
What is the protein family that this protein belongs to?
Belongs to the Dps family.
What are the subcellular locations of this protein?
Cytoplasm.