PharMolix/UniProtQA huggingface dataset:
Protein: RL10_FRAT1
Sequence: MALRIEDKKAIVAEVAEQVSSALSAAVADYRGLTVNEMTSLRKQARESGVYLRVVRNNLARLAIKGTEFECLADALKGPLVLALSKDEPGAAAKLFKNFQKDHNAFEVKNLAMSGELFGPEKLDDFAKLPTREEALATLLNVMQAPVTKFVRTLNEIPSQAVRVFAAVGDSK
What is the function of this protein?
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
What are the official names of this protein?
50S ribosomal protein L10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL10 family.
Protein: FLGI_PSEF5
Sequence: MLNFKHLMAAALLLSTSLGVQAERLKDIASISGVRSNQLIGYGLVVGLNGTGDQTTQTPFTLQTFNNMLSQFGIKVPAGSGNVQLKNVAAVSVSADLPAFAKPGQQVDITVSSIGNSKSLRGGTLLLTPLKGIDGNVYAIAQGNLVVGGFDAEGRDGSKITVNVPSAGRIPGGASVERAVPSGFNQGNSLTLNLNRSDFTTAKRIVDKINDMLGPGVAQAIDGGSIRVTAPLDPSQRVDYLSILENLEIDPGQAVAKVIINSRTGTIVIGQNVKVSPAAVTHGSLTVTITEDPIVSQPGPLSNGQTAVVPRSRVNAQQEAKPMFKFGPGTTLDEIVRAVNQVGAAPGDLMAILEALKQAGALQADLIVI
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar P-ring protein, Basal body P-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgI family.
What are the subcellular locations of this protein?
Periplasm. Bacterial flagellum basal body.
Protein: NGCF_STRCO
Sequence: MKDTIPTAETASRRPEPAARGGRPRRRKLTFDRVTFFLAFLGVPLAIFVIFVLIPFGQAIFWGMTDWRGFSPDYNFVGFDNFTKMFQDDIFLKALRNVALLAAFVPLVTLTLALGVAVAITLGGPSKGPVRGIRGASFYRIISFFPYVVPAIIVGLIWAQMYDPNAGLLNGVLTGLGLDQFDTFAWLGEKAAAMPAVMFVIVWGLVGFYAVLFIAAIKGVPGELYEAAKIDGAGRFRTTISITLPAIRDSVQTAYIYLGIAALDAFVYVQAMVPNGGPDNSTLTISQRLFNVAFAKQQFGYATAMGVVLAAVTLVFAALVFLVNRLTGGGEGESKRKAPGSRARRAAAKGGAR
What is the function of this protein?
Part of the ABC transporter complex NgcEFG-MsiK involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake.  Responsible for the translocation of the substrate across the membrane.
What are the official names of this protein?
Diacetylchitobiose uptake system permease protein NgcF.
What is the protein family that this protein belongs to?
Belongs to the binding-protein-dependent transport system permease family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: DNAJ_SYNE7
Sequence: MQNFRDYYALLGIPQSADQAAIKAAFRKLARQCHPDLNPGDRQAEERFKQISEAYEILSDPDRRAEYQRFSRYWQQQGAASVGSDDDYGDFPDFDIFVDELLGRRTVERSPRRSARRSAATSSALSRDLERSLEVDPKTALQGGSAQLQLEDGRLLEVDIPAGIQAGEYLRLRGQGIKGGDLLLRVQLQASNFQVQGSDVIYTLNVSPAMAVLGGQVTVPTLDGPVQMKLPASLRSGQRLRLAGKGYSKPSGDRGDQIVVIQLQLPTRLSPEERQLYEQLRSLEQSR
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity).
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEMH_BORPE
Sequence: MFLRLFKYLWPERYLPETPAQDPFDENPPPCGPGRVGVLLVNLGTPDEPTRGAIRRYLGEFLSDPRVIEIPRYLWMPILHGLVLTMRPKKLAPRYAGIWMEEGSPLLVYSQRQAAGVRQGLAARGVHAEVELAMRYGKPSIPAAITALRERGCDHILAVPLYPQYAASTTATVVDAVTRHAGRLRDQPALRFVKRFHNDPAYVEAQAGRIAEFWQAHGRPQKLVMSFHGLPRYSIELGDPYYRDCLDTARLLRERLGLREDEVEVTFQSRFGSARWLEPYTEPTLAELARQGVTEVDVVCPGFVADCLETLEEISQECRDAFVAAGGRQFRYIPALNDCPPWIEGLTDLVERQLRGWPTGNP
What is the function of this protein?
Catalyzes the ferrous insertion into protoporphyrin IX.
What are the official names of this protein?
Ferrochelatase, Heme synthase, Protoheme ferro-lyase.
What is the protein family that this protein belongs to?
Belongs to the ferrochelatase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HLDE_ECO7I
Sequence: MKVTLPEFERAGVMVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIASLGANARLVGLTGIDDAARALSKSLADVNVKCDFVSVPTHPTITKLRVLSRNQQLIRLDFEEGFEGVDPQPLHERINQALSSIGALVLSDYAKGALASVQQMIQLARKAGVPVLIDPKGTDFERYRGATLLTPNLSEFEAVVGKCKTEEEIVERGMKLIADYELSALLVTRSEQGMSLLQPGKAPLHMPTQAQEVYDVTGAGDTVIGVLAATLAAGNSLEEACFFANAAAGVVVGKLGTSTVSPIELENAVRGRADTGFGVMTEEELKLAVAAARKRGEKVVMTNGVFDILHAGHVSYLANARKLGDRLIVAVNSDASTKRLKGDSRPVNPLEQRMIVLGALEAVDWVVSFEEDTPQRLIAGILPDLLVKGGDYKPEEIAGSKEVWANGGEVLVLNFEDGCSTTNIIKKIQQDKKG
What is the function of this protein?
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
What are the official names of this protein?
Bifunctional protein HldE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the cytidylyltransferase family.
Protein: RECX_GEOKA
Sequence: MGTIADIAATEQNAERFWIVVHRDGAPSLRLTVDQDVLLQFRLKKGMEISDDLLQHIVYADEVKKAYQQALYFLAHRMRSEHEVAAHLRKKGAPDSVIDEVLKKLRAERYVDDEAFAAAYVRTQKKTAAKGPLLVRAELERLGVPDRLIEQSLAEYTLDEQMAIARSLYEKAKKQRRDESARAFLERVRQQLMRKGFPHEVIAAVLADGGTHTEQEEREALSVQAEKAHRRYAHHPRPLYEQKMRQALYRKGFALDLINEWLRMHGNDE
What is the function of this protein?
Modulates RecA activity.
What are the official names of this protein?
Regulatory protein RecX.
What is the protein family that this protein belongs to?
Belongs to the RecX family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYY_PROMP
Sequence: MVDKFELPKWLLRGIEESFPLRNFDQTLSSKINDANKSKSKLRVKLGIDPTGTDIHLGHSILFKKLRAFQDNGHVAVLIIGDFTAQIGDPTGKNKTRVQLSEEEVKENSKTYLNQLGMGKSSDKSILDFDSEDRIEIRYNSEWLKNLNLNSIIELMGSATVSQMLAKEEFNKRYNSQTPIALHEFLYPLLQGYDSVAVNSDIELGGTDQKFNIAIGRDLQRHFKQEPQYGILLPILTGLDGIKKMSKSESNTVGLSEDSLSMYSKLEKVPDNIIPSYFELLTELDLTLLKDNNPRDLQRRMALEVTSLYHGKEEALRAQSNCEKLFLGLKEKVGEIPIISLKEIVFPVKFFYLLSSLNLFKSSSESKRSIKGGGVKIDSYKLVNPDLVFDSKEDLSGKILQIGKKIIKRFDN
What is the function of this protein?
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
What are the official names of this protein?
Tyrosine--tRNA ligase, Tyrosyl-tRNA synthetase, TyrRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EBNA1_EBVB9
Sequence: MSDEGPGTGPGNGLGEKGDTSGPEGSGGSGPQRRGGDNHGRGRGRGRGRGGGRPGAPGGSGSGPRHRDGVRRPQKRPSCIGCKGTHGGTGAGAGAGGAGAGGAGAGGGAGAGGGAGGAGGAGGAGAGGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGGAGGAGAGGGAGGAGGAGAGGGAGAGGAGGAGGAGAGGAGAGGGAGGAGGAGAGGAGAGGAGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGGAGAGGGAGGAGAGGAGGAGAGGAGGAGAGGAGGAGAGGGAGAGGAGAGGGGRGRGGSGGRGRGGSGGRGRGGSGGRRGRGRERARGGSRERARGRGRGRGEKRPRSPSSQSSSSGSPPRRPPPGRRPFFHPVGEADYFEYHQEGGPDGEPDVPPGAIEQGPADDPGEGPSTGPRGQGDGGRRKKGGWFGKHRGQGGSNPKFENIAEGLRALLARSHVERTTDEGTWVAGVFVYGGSKTSLYNLRRGTALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFMVFLQTHIFAEVLKDAIKDLVMTKPAPTCNIRVTVCSFDDGVDLPPWFPPMVEGAAAEGDDGDDGDEGGDGDEGEEGQE
What is the function of this protein?
Responsible for the origin of replication (oriP) dependent replication and maintenance of viral episomes during latent infection (PubMed:2996781, PubMed:15479791).  EBNA1 dimer interacts with the DS (dyad symmetry) element within the origin of replication oriP and with a host mitotic chromosome to initiate viral DNA replication during latency (PubMed:2996781, PubMed:8551585, PubMed:24067969, PubMed:31142669).  EBNA1 binding to DS recruits the host origin recognition complex (ORC) (PubMed:12953058).  Governs the faithful mitotic segregation of the viral episomes by binding both the FR (family of repeats) element within oriP and the host mitotic chromosomes (PubMed:15479791, PubMed:11172042, PubMed:24067969).  Forms a cell cycle-dependent tyrosine-dependent DNA cross-link and single-strand cleavage at oriP required for terminating replication and maintaining viral episomes (PubMed:33482082).  Counteracts the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival (PubMed:15808506).  Induces degradation of host PML through the ubiquitin-proteasome system, which promotes lytic reactivation and may impair the host cell DNA repair (PubMed:18833293).  Displays inhibitory effects on a SUMO2-modified complex that includes STUB1, KAP1 and USP7 (PubMed:32176739).  This inhibitory effect possibly participates to the maintenance of latency linked to PML silencing (PubMed:32176739).
What are the official names of this protein?
Epstein-Barr nuclear antigen 1, EBNA-1, EBV nuclear antigen 1.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae EBNA1 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: MAFG_CHICK
Sequence: MTTPNKGNKALKVKREPGENGTSLTDEELVTMSVRELNQHLRGLSKEEIIQLKQRRRTLKNRGYAASCRVKRVTQKEELEKQKAELQQEVEKLASENASMKMELDALRSKYEALQNFARTVARSPVTPVRGPLTSSMGPLVPGKVATTSVITIVKSKTDARS
What is the function of this protein?
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves.  However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites.  Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.  Transcription factor, component of erythroid-specific transcription factor NF-E2.  May be involved in signal transduction of extracellular H(+) (By similarity).
What are the official names of this protein?
Transcription factor MafG, V-maf musculoaponeurotic fibrosarcoma oncogene homolog G.
What is the protein family that this protein belongs to?
Belongs to the bZIP family. Maf subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: PLP_RICBR
Sequence: MKKLSIVLLSVSMLSSIAFADNSDRVVATYTGGEVRESQIMKEFKPQLNLPSGETIKNFDDFPPQDQDKLIRIYVNNILLKKEVEKSNITSSKEFQEKLENAKNQLAQKELLENYVKSNLTDKMFDDEYNKYVTSLKGKEQIKVAHILVKSEKEANDLKNKLNKGADFAKLAGESSLDKASATNGGVIGYILLNQPGQLVPEFENKAFALKVNEVSTPVKTDYGWHIIKVLEKKPVPIPTKEEAKMTIDNVLAAEILKKYISDLEAKADLKIMLPPAANNEAKK
What are the official names of this protein?
Parvulin-like PPIase, Peptidyl-prolyl cis-trans isomerase plp, Rotamase plp.
What is the protein family that this protein belongs to?
Belongs to the PpiC/parvulin rotamase family.
What are the subcellular locations of this protein?
Cell outer membrane.
Protein: ARLY_NOSP7
Sequence: MTKEQTWSQRFESALHPAIARFNASIGFDIELIEYDLTGSQAHAKMLAHTGIISSEEGEQLVAGLEQIRQEHRQGKFHPGVDAEDVHFAVEKRLTEIVGDVGKKLHTARSRNDQVGTDTRLYLRDQIQQIKSELREFQGVLLDIAEKHVETLIPGYTHLQRAQPVSLAHHLLAYFQMAQRDWERLGDVSRRVNISPLGCGALAGTTFPIDRHYTAKLLDFDNIYANSLDGVSDRDFAIEFLCAASLIMVHLSRLAEEVILWSSEEFRFVILKDSCATGSSIMPQKKNPDVPELVRGKTGRVFGHLQAMLVIMKGLPLAYNKDLQEDKEGLFDSVNTVKASLEAMTILLREGLEFRTQRLAQAVTEDFSNATDVADYLAARGVPFREAYNLVGKVVKTSIAAGKLLKDLELEEWQQLHPAFAADIYEAISPRQVVAARNSHGGTGFVQVSKALIAARAQIDQ
What are the official names of this protein?
Argininosuccinate lyase, ASAL, ASL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YCCU_ECOLI
Sequence: MKETDIAGILTSTHTIALVGASDKPDRPSYRVMKYLLDQGYHVIPVSPKVAGKTLLGQKGYGTLADVPEKVDMVDVFRNSEAAWGVAQEAIAIGAKTLWMQLGVINEQAAVLARDAGLNVVMDRCPAIEIPRLGLAK
What are the official names of this protein?
Uncharacterized protein YccU.
Protein: SYM_CHLTB
Sequence: MESSRILITSALPYANGPLHFGHITGAYLPADVYARFQRLQGKEVLYICGSDEYGIAITLNAELAGMGYQEYVDMYHKLHKDTFKKLGISVDFFSRTTNAYHPAIVQDFYRNLQERGLVENQVTEQLYSEEEGKFLADRYVVGTCPKCGFDRARGDECQQCGADYEARDLKEPRSKLTGAALSLRDTEHAYLHLERMKEDLLAFVQGIYLRPHMRNFVTDYIEHLRPRAVTRDLSWGIPVPDLENKVFYVWFDAPIGYISGTMDWAASIGDPEAWKKFWLDDTVTYAQFIGKDNTSFHAVIFPAMEIGQSLPYKKVDALVTSEFLLLEGFQFSKSDGNFIDMDAFLETYSLDKLRYVLAAIAPETSDSEFSFQEFKTRCNSELVGKYGNFVNRVLAFAVKNGCTELSSPQLEQKDLDFISKSQKLAKDAAEHYAQYSLRKACSTIMELAALGNGYFNDEAPWKLAKEGNWNRVRAILFCACYCQKLLALISYPIMPETALKILEMIAPYSLDLGSQDPDRLHSLWTDSFFDYSEEKFSLKEPELLFTMVE
What is the function of this protein?
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
What are the official names of this protein?
Methionine--tRNA ligase, Methionyl-tRNA synthetase, MetRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL29_SULTO
Sequence: MKSKEILGYDIKEISNQTVEQLIEKKKELQGKLNDLQQELLKRKVEARMGTLKNTASIRNLRKDIARILTLLSIINKEIENKKKESKK
What are the official names of this protein?
50S ribosomal protein L29.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL29 family.
Protein: ECHH_CAEEL
Sequence: MLRAVSTSFGTARAASAVAKKNMPNIVLVDAVRTPFVVSGTVFKDLMAVDLQKEAIKALVEKTKLPYEQLDHIICGTVIQECKTSNIAREAALLAGVPDKIPAHTVTLACISSNVAMTTGMGMLATGNANAIIAGGVELLSDVPIRYNRNARKAMLGMNKAKDVPSKLKIGGQIVKNLLSPELPAVAEFSTGETMGHSGDRLAAAFNVSRREQDEFAIRSHTLASEAAKNGKFTDVVPVFLDGKKPKTIKEDNGIRVSTLEKLSSLKPAFVKPHGTVTAANASYLTDGASAALIMTEEYALANGYKPKAYLRDYLYVAQDPKDQLLLSPAYVIPKLLDKAGLTLKDVDVFEIHEAFAGQVLANLNAMDSDYFCKEQMKRSGKFGRVPMDKLNLWGGSLSIGHPFGATGVRLATHSAHRLKEEKGQYAVIAACAAGGHGVGMLIEAYGK
What is the function of this protein?
Mitochondrial enzyme that catalyzes reactions of the mitochondrial beta-oxidation pathway.
What are the official names of this protein?
Probable 3-ketoacyl-CoA thiolase.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Mitochondrion.
Protein: MURA_METFK
Sequence: MDKLVIQGGVPLHGEISVSGAKNAALPILCAGLLTDGPLTLDNVPQLQDIATMRKLLLHMGVKIAELGAHCLRLDASDVHTCEAPYDMVKTMRASILVLGPLLARFGHARVSLPGGCAIGSRPVDLHIKGLQAMGAEIHIDHGYIEAKAAKLKGARVFMDIVTVTGTENLMMAATLADGLTILENAAKEPEVVDLAECLVKMGAKIEGAGTDVITVTGVASLHAASHDVVCDRIEAGTYMVATAMTGGEVRLSNARADLLDAVIDKLRESGAEVECSDNSIIVRSKGVVEHPGTLKSVSIRTAPHPAFPTDMQAQFMALNTVADTVATVTETIFENRFMHVQEMQRLGANIEVEGNTAIVRGREFLEGATVMATDLRASASLVLAALVARGETVIERIYHLDRGYERLEEKLRQLGARIQRIK
What is the function of this protein?
Cell wall formation.  Adds enolpyruvyl to UDP-N-acetylglucosamine.
What are the official names of this protein?
UDP-N-acetylglucosamine 1-carboxyvinyltransferase, Enoylpyruvate transferase, UDP-N-acetylglucosamine enolpyruvyl transferase, EPT.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family. MurA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YR648_MIMIV
Sequence: MMDNMQCGYYNSGSPYNFPSVLGPGAAIGPGPVPLGYCKEPCPTRSLCDPSYIGACGIQPLINPFGPRRAVTTWKINYLVSNRTNQAAHTDPDLINPWGIAIFGNQLWIANGQTDTITNYDLFGNKLLGSITVRNIAQNSSYPTGIAINCTGNFATTNGTLTKSGLFLTCSEHGTVHSYNPQVDPLVSFLVLNEQLTGEIHVFRGLAVAGDVLYLADFFQSKIMVFDSNYNRLLGFPFVDGDTSDPIPISYGPTNIVNIGCYLYVVYARKDPNVPLQAITGAGFGYISIFNLDGTFVRRFTSRGVLNDPWAIIPAPVECGFPPGSLLVSNHGDGRINAFDCNGRYVGPMLNQSGLPVIIDGLRGLAPHYTDFNEIFFTAEVDENIDGLVGSICKDQVIYF
What are the official names of this protein?
Uncharacterized protein R648.
What is the protein family that this protein belongs to?
Belongs to the mimivirus R640 family.
What are the subcellular locations of this protein?
Virion.
Protein: CAS9_ACTNH
Sequence: MWYASLMSAHHLRVGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGVGKEGKKDHDTRKKLSGIARRARRLLHHRRTQLQQLDEVLRDLGFPIPTPGEFLDLNEQTDPYRVWRVRARLVEEKLPEELRGPAISMAVRHIARHRGWRNPYSKVESLLSPAEESPFMKALRERILATTGEVLDDGITPGQAMAQVALTHNISMRGPEGILGKLHQSDNANEIRKICARQGVSPDVCKQLLRAVFKADSPRGSAVSRVAPDPLPGQGSFRRAPKCDPEFQRFRIISIVANLRISETKGENRPLTADERRHVVTFLTEDSQADLTWVDVAEKLGVHRRDLRGTAVHTDDGERSAARPPIDATDRIMRQTKISSLKTWWEEADSEQRGAMIRYLYEDPTDSECAEIIAELPEEDQAKLDSLHLPAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEAINAPVGNPSVDRTLKIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMADERDKANRRRYNDNQEAMKKIQRDYGKEGYISRGDIVRLDALELQGCACLYCGTTIGYHTCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSNTPFAVWAQKCGIPHVGVKEAIGRVRGWRKQTPNTSSEDLTRLKKEVIARLRRTQEDPEIDERSMESVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSRINLIGEKGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTGKEQTWKQYTGSTVGAREHFEMWRGHMLHLTELFNERLAEDKVYVTQNIRLRLSDGNAHTVNPSKLVSHRLGDGLTVQQIDRACTPALWCALTREKDFDEKNGLPAREDRAIRVHGHEIKSSDYIQVFSKRKKTDSDRDETPFGAIAVRGGFVEIGPSIHHARIYRVEGKKPVYAMLRVFTHDLLSQRHGDLFSAVIPPQSISMRCAEPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDFPNTTRWRICGYDTNSKLTLKPIVLAAEGLENPSSAVNEIVELKGWRVAINVLTKVHPTVVRRDALGRPRYSSRSNLPTSWTIE
What is the function of this protein?
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids).  CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids.  CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).  In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein.  The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA.  Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA).  Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs.  PAM recognition is also required for catalytic activity (By similarity).
What are the official names of this protein?
CRISPR-associated endonuclease Cas9, AnaCas9.
What is the protein family that this protein belongs to?
Belongs to the CRISPR-associated protein Cas9 family. Subtype II-C subfamily.
Protein: MLP43_ARATH
Sequence: MAEASSLVGKLETEVEIKASAKKFHHMFTERPHHVSKATPDKIHGCELHEGDWGKVGSIVIWKYVHDGKLTVGKNKIEAVDPEKNLITFKVLEGDLMNEYKSFAFTLQVTPKQGESGSIAHWHLEYEKISEEVAHPETLLQFCVEISKEIDEHLLAEE
What are the official names of this protein?
MLP-like protein 43.
What is the protein family that this protein belongs to?
Belongs to the MLP family.
Protein: SURF4_BOVIN
Sequence: MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCILVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSILQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW
What is the function of this protein?
Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion.  Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis.  Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins.  Promotes the secretion of PCSK9.  Also mediates the efficient secretion of erythropoietin (EPO).  May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi.
What are the official names of this protein?
Surfeit locus protein 4.
What is the protein family that this protein belongs to?
Belongs to the SURF4 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.
Protein: RS21_ORITI
Sequence: MIHVPVNANNSELAIRSLKKKMQRELVFRSMKMSRFYEPPSVKRVRKKQESERRHRKERAMRRRMMEE
What are the official names of this protein?
30S ribosomal protein S21.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS21 family.
Protein: ACKA_DEIGD
Sequence: MWTLVVNCGSSSLKFALLNPATGETPLTGLAERLGSDLAAVRVDRGEERGTVPLPQGSYSEAFGVLLAELDALGLRQEVRAVGHRVVHGGDRFNAPVRITPEVLEVIRTCIPLAPLHNPANLAGIEAALAAFPELPQVAVFDTAFHQSMPPVAYRYAVPTVWYTCYGVRRYGFHGISHAYVAEEAARLLARDLTDLSLVTAHLGNGCSVTAVQGGRSLDTSMGLTPLEGLVMGTRSGDVDPGLPDYLAREAGLTLAEITAALNRESGLLGLSGLTNDMRELEAAAAGGNTNAQLALEIFVYRLAKTIAGMATVLGRLDALVFTGGIGENSATVRAATLARLGLLGFQLDAAANAQAVRGQGGVITSGGVPALVVNTNEERMIARETARAVKGAPA
What is the function of this protein?
Catalyzes the formation of acetyl phosphate from acetate and ATP.  Can also catalyze the reverse reaction.
What are the official names of this protein?
Acetate kinase, Acetokinase.
What is the protein family that this protein belongs to?
Belongs to the acetokinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CLPX_BURL3
Sequence: MADKKGSNSEKLLYCSFCGKSQHEVKKLIAGPSVFICDECIDLCNEIIRDEAAAAGVEASLSRSDLPSPQEIRDILDQYVIGQERAKKILAVAVYNHYKRLKHLDKKDDVELSKSNILLIGPTGSGKTLLAQTLARLLNVPFVIADATTLTEAGYVGEDVENIIQKLLQNCNYEVDKAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLVEGTMASVPPQGGRKHPNQDFIQVDTTNILFICGGAFDGLEKVITDRTEKTGIGFGATVKSKQERDAGEVLRETEPEDLIKFGLIPELIGRLPVVATLGKLDEAALMKILVEPKNALVKQYHKLFAMERVELEIRPGALQAVARKAIRRKTGARGLRSIIEQALLDVMYELPTMKGVSKVIIDENVIDGDGKPLLIYEDTPKVAGSN
What is the function of this protein?
ATP-dependent specificity component of the Clp protease.  It directs the protease to specific substrates.  Can perform chaperone functions in the absence of ClpP.
What are the official names of this protein?
ATP-dependent Clp protease ATP-binding subunit ClpX.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family.
Protein: LEXA_ERWT9
Sequence: MKALTARQQQVYDLIRDHINQTGMPPTRAEIAAQLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLMMEDESGLPLIGRVAAGEPLLAEQHIEGHYQVDPGLFKPGADFLLRVSGMSMKNIGIMDGDLLAVHKTEDVRNGQVVVARIDDEVTVKRLKKNGNMVELLPENPDFQPIVVDLRQQTLTIEGLAVGVIRNGNWL
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: RS3_COXB2
Sequence: MGQKVNPVGMRIGITRDWTSNWYADKKDFADRLNEDLNVRQLLQKRLKGAAVSRIQIERPARNAKIIIHSARPGVIIGKKGGEIEALRDEISKVMKVPVHITIEEVRKPELDAKLVAENIAQQLERRVMFRRAMKRAVQNTLRQGALGVKISVSGRLGGAEIARTEWYREGRVPLHTFRADIDYATASAKTTYGIIGVKVWIFKGEVHAPKPQAEEAAPQETEEEVK
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: DEF1_BORPA
Sequence: MALLSILRYPDPRLHKTAKPVAVVDDRIRQLVRDMADTMYDAPGVGLAATQVDVHERVVVIDVSEEGNDLRVLINPEITWKSDERQTYEEGCLSVPGIYDEVERAARIRCKALDQQGQPYEFEADGLLAVCVQHEIDHLDGKVFVEYLSNLKQNRIKTKLKKAEREAERA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase 1, PDF 1, Polypeptide deformylase 1.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.