PharMolix/UniProtQA huggingface dataset:
Protein: PRR37_ORYSI
Sequence: MMGTAHHNQTAGSALGVGVGDANDAVPGAGGGGYSDPDGGPISGVQRPPQVCWERFIQKKTIKVLLVDSDDSTRQVVSALLRHCMYEVIPAENGQQAWTYLEDMQNSIDLVLTEVVMPGVSGISLLSRIMNHNICKNIPVIMMSSNDAMGTVFKCLSKGAVDFLVKPIRKNELKNLWQHVWRRCHSSSGSGSESGIQTQKCAKSKSGDESNNNSGSNDDDDDDGVIMGLNARDGSDNGSGTQAQSSWTKRAVEIDSPQAMSPDQLADPPDSTCAQVIHLKSDICSNRWLPCTSNKNSKKQKETNDDFKGKDLEIGSPRNLNTAYQSSPNERSIKPTDRRNEYPLQNNSKEAAMENLEESSVRAADLIGSMAKNMDAQQAARATNAPNCSSKVPEGKDKNRDNIMPSLELSLKRSRSTGDDANAIQEEQRNVLRRSDLSAFTRYHTPVASNQGGTGFVGSCSPHDNISEAMKTDSAYNMKSNSDAAPIKQGSNGSSNNNDMGSTTKNVVTKPSTNKERVMSPSAVKANGHTSAFHPAQHWTSPANTTGKEKTDEVANNAAKRAQPGEVQSNLVQHPRPILHYVHFDVSRENGGSGAPQCGSSNVFDPPVEGHAANYGVNGSNSGSNNGSNGQNGSTTAVNAERPNMEIANGTINKSGPGGGNGSGSGSGNDMYLKRFTQREHRVAAVIKFRQKRKERNFGKKVRYQSRKRLAEQRPRVRGQFVRQAVQDQQQQGGGREAAADR
What is the function of this protein?
Controls photoperiodic flowering response.  Seems to be one of the component of the circadian clock.  Expression of several members of the ARR-like family is controlled by circadian rhythm.  The particular coordinated sequential expression of PRR73, PRR37, PRR95, PRR59 and PPR1 result to circadian waves that may be at the basis of the endogenous circadian clock (By similarity).
What are the official names of this protein?
Two-component response regulator-like PRR37, Pseudo-response regulator 37, OsPRR37.
What is the protein family that this protein belongs to?
Belongs to the ARR-like family.
What are the subcellular locations of this protein?
Nucleus.
Protein: IL21_PIG
Sequence: MRWPGNMEKIVICLMVIFSGTVAHKSSFQGQDRLLIRLRQLIDTVDQLKNYVHDLDPELLPAPEDVQRHCEQSAFSCFQKVELKSANTGDNEKIINVLIKQLKRKLPPTNAGRRQKHGLTCPTCDSYEKKPIKEFLERLKSLIQKMIHQHLS
What is the function of this protein?
Cytokine with immunoregulatory activity.  May promote the transition between innate and adaptive immunity (PubMed:15107555).  Induces the production of IgG(1) and IgG(3) in B-cells.  Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers.  Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity).  May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15.  May regulate proliferation of mature B- and T-cells in response to activating stimuli.  In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity).  During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
What are the official names of this protein?
Interleukin-21, IL-21.
What is the protein family that this protein belongs to?
Belongs to the IL-15/IL-21 family.
What are the subcellular locations of this protein?
Secreted.
Protein: TBA2_ANEPH
Sequence: LFHPEQLISGKEDAANNFARGHYTVGKEIVDLCLDRVRKLSDNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLLDIERPTYTNLNRLVSQIISSLTTSLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVISAAKAYHEQLSVPEITNAVFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTVQFVDWCPTGFKCGINYQPPSVVPGGDLAKVQRAVCMISNNTAVAEVFSRIDHKFDLMYAKLAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVAAEGVDEPEGDDY
What is the function of this protein?
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers.  Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms.  Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
What are the official names of this protein?
Tubulin alpha-2 chain.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: RNZ_SULIK
Sequence: MIQIFFLGTGAGSPSKKRKLPAFLVRREGLNILLDCGEGTQYTLMNNKLGINSIKIIGITHMHGDHVFGLLGVIASMGLLDRKETLYILGPRDLKDFLYTSFEYSKFNPSFKIEFIDNYNDQNITIATFKTCHTVESQGYLISERDRVKIDEEKLEKEKIKDWRVMRKLKEGKTVEYNGKFLKPEDYLVIKRGLKVAYTGDTIPCQSVIESVKGVDLLIHDSTFLNEPSACTYGHSNVADAAKVALEASVKLLALTHISPRYEDVTEHLKVARRIFPKSILPDDLSYITLK
What is the function of this protein?
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity.  Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
What are the official names of this protein?
Ribonuclease Z, RNase Z, tRNA 3 endonuclease, tRNase Z.
What is the protein family that this protein belongs to?
Belongs to the RNase Z family.
Protein: TRM1_METM6
Sequence: MKIISEGETKLMVPEESTLSKKDTVFYNPMMETNRDISVSVVQSFLDNFNRDEFLMCDPLGGSGARGIRYANELKFNGDLKVSIGDINPSAVKMIKENLKLNELENVEVFHEDANVLLSKNFKIFNVVDLDPFGSPVPYLDSGIRASLTKGGLLCMTATDTAVLCGAYRKTCIRKYNAIPLKGDKELAVRLMIGYAVKMASKYDIGLKPIFSHVTDHYARTFMVTERGAGKADSAIENLGYIRQDSEQKSFKSFEEGYEKGYTGPFYLGEISDNDIVQNSLETAKNRNYSKRAVDILELISKESKIEQVGCFDIHELCSFIKKLVPPVNDIMKNLKENGFKVSRVHYNPYGLKTDAELSDLVVLISEYHSKKY
What is the function of this protein?
Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
What are the official names of this protein?
tRNA (guanine(26)-N(2))-dimethyltransferase, tRNA 2,2-dimethylguanosine-26 methyltransferase, tRNA(guanine-26,N(2)-N(2)) methyltransferase, tRNA(m(2,2)G26)dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Protein: PER15_ARATH
Sequence: MARIGSFLIILYLIYALTLCICDDDESNYGGDKGNLFPGFYRSSCPRAEEIVRSVVAKAVARETRMAASLMRLHFHDCFVQGCDGSLLLDTSGSIVTEKNSNPNSRSARGFEVVDEIKAALENECPNTVSCADALTLAARDSSVLTGGPSWMVPLGRRDSTSASLSGSNNNIPAPNNTFNTIVTRFNNQGLDLTDVVALSGSHTIGFSRCTSFRQRLYNQSGNGSPDRTLEQSYAANLRQRCPRSGGDQNLSELDINSAGRFDNSYFKNLIENMGLLNSDEVLFSSNEQSRELVKKYAEDQEEFFEQFAESMIKMGNISPLTGSSGEIRKNCRKINNS
What is the function of this protein?
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress.  These functions might be dependent on each isozyme/isoform in each plant tissue.
What are the official names of this protein?
Peroxidase 15, Atperox P15, ATP36.
What is the protein family that this protein belongs to?
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: SURE_ECO7I
Sequence: MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLDGHKHYDTAAAVTCSILRALCKEPLRTGRILNINVPDLPLDQIKGIRVTRCGTRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPGTDFAAVDEGYVSITPLHVDLTAHSAQYVVSDWLNSVGVGTQW
What is the function of this protein?
Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP.  Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25).  Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.
What are the official names of this protein?
5'/3'-nucleotidase SurE, Exopolyphosphatase, Nucleoside monophosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the SurE nucleotidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ICOS_MOUSE
Sequence: MKPYFCRVFVFCFLIRLLTGEINGSADHRMFSFHNGGVQISCKYPETVQQLKMRLFREREVLCELTKTKGSGNAVSIKNPMLCLYHLSNNSVSFFLNNPDSSQGSYYFCSLSIFDPPPFQERNLSGGYLHIYESQLCCQLKLWLPVGCAAFVVVLLFGCILIIWFSKKKYGSSVHDPNSEYMFMAAVNTNKKSRLAGVTS
What is the function of this protein?
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.  Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens.  Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10.  Prevents the apoptosis of pre-activated T-cells.  Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
What are the official names of this protein?
Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD28 and CTLA-4-like protein, CCLP, CD28-related protein 1, CRP-1.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: RL4_ACIB5
Sequence: MNLKTVSGSAVELSEVAFGREFNEALVHQVVTAYLAGGRQGTRAHKSRADVSGGGKKPFRQKGTGRARAGSIRSPIWVGGGKTFAARPQDWSQKVNRKMYRGAMQCILAELVRQDRLVLVEEFAVAAPKTKELLAKLNDLNAARALIVTDAVDENLYLAARNLPHVDVVDATAIDPVSLIAFDKVVMSVAAAKKIEVELG
What is the function of this protein?
Forms part of the polypeptide exit tunnel.
What are the official names of this protein?
50S ribosomal protein L4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL4 family.
Protein: CSD_PASMU
Sequence: MDYGKTLTQSLLSNGADKRENKMAFNPSVFKQHFPYLQQADAVVYLDSAATALKPQVLTDATIAFYQSAGSVHRSQYDEKQTALFEQARENVKNFIGAESEETIIWTSGTTHAINCVARGLSHQLHPKAEIIISEADHHANFVTWSEIARQYGATLHILPINEQWLIEEQDLIAVLNTNTVLVALNMVSNVTGTEQPVANLIKLIRQHSHALVLVDAAQAISHLPIDLQRLDADFIAFSAHKLYGPNGLGVLSGKRHALEQLHPLLYGGKMVERVSAQHIRFAELPYRLEAGTPNIAGVIGFNAVLEWLSQWDLTAAEQHAIALAEQCKMRLKNYPHCQLFLSPQPSSIVCFVFNGIATSDIATLLAEQNIALRAGEHCAQPYLARLGQHSTLRLSFAPYNQQADVDAFFSALDNALALLD
What is the function of this protein?
Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
What are the official names of this protein?
Probable cysteine desulfurase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
Protein: GATC_CUPMC
Sequence: MALALSDVKRIAHLARIETSDAEAEQTLAQLNNFFSLVEQMQAVDTTGIEPLAHPLSAVRDIAQRLREDAVTESDRRADYQRPAPATENGLYLVPKVIE
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C, Asp/Glu-ADT subunit C.
What is the protein family that this protein belongs to?
Belongs to the GatC family.
Protein: RNPH_COREF
Sequence: MTSTTSFTRADGRAQDQMRTVKITRGFTTNPAGSVLIEFGNTRVMCTASVELGVPRFKRDSGEGWLTAEYAMLPAATAERNRRESMAGKVKGRTHEISRLIGRSLRAAVDLSQLGENTIAIDCDVLQADGGTRTAAITGAYVALADAIRVLKEQGVVPGDPLLPPVAAVSVGLIDGQPCLDLPYEEDVRADVDMNVVMTESGEFVEIQGTGEETTFTRAQLNEMLDIAEKGCRELVHAQKAALGI
What is the function of this protein?
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation.  Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important.  Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
What are the official names of this protein?
Ribonuclease PH, RNase PH, tRNA nucleotidyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family.
Protein: NRX1_ARATH
Sequence: MAETSKQVNGDDAQDLHSLLSSPARDFLVRNDGEQVKVDSLLGKKIGLYFSAAWCGPCQRFTPQLVEVYNELSSKVGFEIVFVSGDEDEESFGDYFRKMPWLAVPFTDSETRDRLDELFKVRGIPNLVMVDDHGKLVNENGVGVIRSYGADAYPFTPEKMKEIKEDEDRARRGQTLRSVLVTPSRDFVISPDGNKVPVSELEGKTIGLLFSVASYRKCTELTPKLVEFYTKLKENKEDFEIVLISLEDDEESFNQDFKTKPWLALPFNDKSGSKLARHFMLSTLPTLVILGPDGKTRHSNVAEAIDDYGVLAYPFTPEKFQELKELEKAKVEAQTLESLLVSGDLNYVLGKDGAKVLVSDLVGKTILMYFSAHWCPPCRAFTPKLVEVYKQIKERNEAFELIFISSDRDQESFDEYYSQMPWLALPFGDPRKASLAKTFKVGGIPMLAALGPTGQTVTKEARDLVVAHGADAYPFTEERLKEIEAKYDEIAKDWPKKVKHVLHEEHELELTRVQVYTCDKCEEEGTIWSYHCDECDFDLHAKCALNEDTKENGDEAVKVGGDESKDGWVCEGNVCTKA
What is the function of this protein?
Probable thiol-disulfide oxidoreductase required for pollen tube growth and pollen function in the pistil.  Seems not to be required for in vitro pollen tube growth.  May be involved in the generation of lipid signaling molecules in pistil.
What are the official names of this protein?
Probable nucleoredoxin 1, AtNrx1.
What is the protein family that this protein belongs to?
Belongs to the nucleoredoxin family.
Protein: SRBP2_DANRE
Sequence: MDASEFMDTMDPSLSELGDEFTLGDIDEMLQFVSNQVDFPDIFEDQMGGGATARTLPQAVPSAILTPPHTPVQTSSQTHTQTLTQAHTQTHTQTHTQTRTPPVLQPRPQPITQVQTQTFPMQTLAVQTQAQPQTVMITPTATPSRFIQNQVICQQNNATSFQVLQPQMQSIMTSPQVQPMTIQHQRVLTPAGQTIQTLSTAPTTVHTMSQQVPVLVHQPQILKTDSLLLTTKPDGTQVLSTVQSPTGITTLTTPIQTTALQMPTLMSSNILTTVPVVMGGGDKLPIKQLSSGPAHNIGGARVGVEQSPVVGPGGVVKEGERRTTHNIIEKRYRSSINDKILELRDLVLGNDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENLTLKMANQKNKSACVSDVDLELKAEVSLISPPPSDSGSSSPAQLSPYCIDSEPGSPLLEHEQLKSEPDSPSCVGVMDRSRLLLCALSFLCLSLNPLPSLLGAEAPAGSPEVAGHGPTRTLFSLPAQTQSFGAWLWCVLPFLLVWVVSGVGVVWGCVRVLYLWEPVTPLHSPTSVRFWRHRKQADLQLYRGDYAGAVLSLQTCLSVLSRVLPVTTLDIMCSLSWNLIRYCLRRPAPLGWLVRLVGGRHEGEESQTSSRDAALVYHKLSQLQLTGQMERRPLWGVCVSLSAVNLCESAEGKLTATQQVQVYVTAAISVRAALGKHLTCLPAYLLSCAEALTCQSDSKPLPDCLRWIFTPLGRQFFLSCDWSVRSESDGQIFTSARDKADPIAQLHRCFCQKLLERATHTLIEPQSREDAGEFTGVLEFLQLLNSCTEDSAPSTAPFPALANQSSTSVRDPVCRWWASVLTAAVHWLQGDDASVRSLLAEAERMPRALHTLDHPLPKAVLALCKAVQMSVCPQKGEGVVSCLSHCQRASAQLHISVCQSHNNTWLHKGVELLVCDLLLTLRTSLWQRGGGSNGEPGPAPGSQLSGFQRDLSSLRRLGQAHRQAQHKLFLHETTVRLMAGASPTRTHQLLRHRTHNYTTTDGECVLGERERAHAILLACRHLPLPLLTPPGHRARLLAEAKRTLERVGDRRSLQDCQHILLRLSGGTTIAAS
What is the function of this protein?
Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis.  Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3').  Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').  Regulates transcription of genes related to cholesterol synthesis pathway (By similarity).  Activated by mediated cholesterol efflux, transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (PubMed:30705153).
What are the official names of this protein?
Sterol regulatory element-binding protein 2, SREBP-2, Sterol regulatory element-binding transcription factor 2.
What is the protein family that this protein belongs to?
Belongs to the SREBP family.
What are the subcellular locations of this protein?
[Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed. SUBCELLULAR LOCATION: [Processed sterol regulatory element-binding protein 2]: Nucleus.
Protein: Y1967_POLSJ
Sequence: MAGHSKWANIQHRKGRQDEKRQRVWTRVMREIMVAARMGGGDLGTNPRLRLAVDKAKAANMPADNVKYGIAKATGSLEGVHYEEVRYEGYGFGGAAIIVDCMTDNRVRTVAEVRHAFSKHGGHMGTEGSVAFQFKHCGQLIFAPGTSEDKVMEVALEAGADDVITHDDGAIEVLTPYTDFEAVKKALEAAGLKPELAEVTMRADNMIELTGEDARKMQKLLDVLEDLDDTQEVFHNAALDASE
What are the official names of this protein?
Probable transcriptional regulatory protein Bpro_1967.
What is the protein family that this protein belongs to?
Belongs to the TACO1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSBJ_TRIV2
Sequence: MSAGSGRIPLWVVATIAGLGVITVVGIFFYGAYAGLGSSI
What is the function of this protein?
One of the components of the core complex of photosystem II (PSII).  PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.  It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
What are the official names of this protein?
Photosystem II reaction center protein J, PSII-J.
What is the protein family that this protein belongs to?
Belongs to the PsbJ family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Single-pass membrane protein.
Protein: PAR4_CAEEL
Sequence: MDAPSTSSGAQSKLLMPGDDEADEDHQNRGDPNLQQKQKIQLNVDPDYDDDEDDDCFIDGCEASAPITRELVDGAIERRSKDRNVKMSIGVYDEYDDDDDDEEETEEDQRRRFVEGIRNIRHKQQESFDLEEHPIPVESEAMRQFINQQVNNAMMFNQDNSEFQHIEFEPIVKQKGPKIIEGYMWGGQIGTGSYGKVKECIDMYTLTRRAVKIMKYDKLRKITNGWENIRSEMSILRRMNHRNVIKLIEIFNIPAKGKVYMVFEYCIGSVQQLLDMEPARRLTIGESHAIFIELCQGLNYLHSKRVSHKDIKPGNLLVSIDFTVKICDFGVAEQINLFQRDGRCTKVNGTPKFQPPECIYGNHDFFDGYKADMWSAGVTLYNLVSGKYPFEKPVLLKLYECIGTEPLQMPTNVQLTKDLQDLLTKLLEKDFNERPTCLETMIHPWFLSTFPEDQGLGRIMERMRTGDRPLTMLSSMTALYDGITPEDELIIEDNLGIIQQILPINLTSEAVLERGSFPGFKFLEAKPGDGPDGVEGSEDSAAPLGPQRRPSSRSMPTCAPPGPAAGNAQNSTAENGAETDGVASASDPPPTAAPGAPPRRRKRNFFSCIFRSRTDSA
What is the function of this protein?
Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis (PubMed:10704392).  Controls the asymmetric cell division of the Q. p neuroblast lineage (PubMed:23267054).  Involved in mediating cell polarization via regulation of anillin family scaffold proteins (PubMed:21276723).  Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization (PubMed:18842813).  May phosphorylate par-1.  Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein stabilization.  May regulate the integrity of the early embryonic cortex in a strd-1-dependent manner (PubMed:20110331).  Phosphorylates and regulates aak-2 in response to oxidative stress and during dauer development (PubMed:18408008, PubMed:20110331).  May also play a role in motility, behavioral response, regulation of lifespan and dauer formation through this pathway (PubMed:15574588, PubMed:18408008).  Required to establish germline stem cell (GSC) quiescence during dauer development (PubMed:20110331).  Acts downstream of unc-40 in dendrite outgrowth (PubMed:21186357).  May play a role in cell shedding during embryogenesis, probably by phosphorylating pig-1 (PubMed:22801495).
What are the official names of this protein?
Serine/threonine-protein kinase par-4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cell cortex.
Protein: ADRB1_CANLF
Sequence: MGAGALALGASEPCNLSSAAPLPDGAATAARLLVPASPSASPLAPTSEGPAPLSQQWTAGIGLLMALIVLLIVAGNVLVIAAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVMRGRWEYGSFLCELWTSVDVLCVTASIETLCVIALDRYLAITAPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAGGDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPAPPPAPAPAPPPAPGSPRPAAAAPLANGRVGRRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRRAFQRLLCCARRAARGSHGAAGDPPRARPPPSPGAASDDDDDDEDDAGAGAGAAPPARLLEPWAGCNGGAAADSDSSLDGAGSPAGASESRV
What is the function of this protein?
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.  This receptor binds epinephrine and norepinephrine with approximately equal affinity.  Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity).  Involved in the regulation of sleep/wake behaviors (By similarity).
What are the official names of this protein?
Beta-1 adrenergic receptor, Beta-1 adrenoreceptor, Beta-1 adrenoceptor.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome. Note=Colocalizes with RAPGEF2 at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity).
Protein: ADEC1_HUMAN
Sequence: MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE
What is the function of this protein?
May play an important role in the control of the immune response and during pregnancy.
What are the official names of this protein?
ADAM DEC1, A disintegrin and metalloproteinase domain-like protein decysin-1, ADAM-like protein decysin-1.
What are the subcellular locations of this protein?
Secreted.
Protein: HSCA_BURPS
Sequence: MALLQISEPGMAPAPHQRRLAVGIDLGTTNSLVAAVRNSIPEALPDDAGRVLLPSVVRYLDKGGRRIGHAAKEEAAIDPRNTIVSVKRFMGRGKAEVEGAANAPYEFVDAPGMVQIRTVDGVKSPVEVSAEILATLRQRAEDTLGDDLVGAVITVPAYFDDAQRQATKDAARLAGLNVLRLLNEPTAAAIAYGLDNGAEGLYAVYDLGGGTFDLSILKLTKGVFEVLAAGGDSALGGDDFDHLLFEHVLAQAGLEAAALAPEDVRLLLDRVRGAKEALSAAPQARVDVKLSTGEKLAQTITRDTFAALVEPLVQRTLGPTRKALRDAQVSAADIKGVVLVGGATRMPVIRDAVAKYFGQPPLVNLDPDQVVALGAAIQADLLAGNRSGGDDWLLLDVIPLSLGVETMGGLVEKIIPRNSTIPVARAQEFTTFKDGQTAMAIHVVQGERELVSDCRSLARFELRGIPPMTAGAARIRVTYQVDADGLLSVFAREQHSGVEASVVVKPSYGLGDDDIARMLEDSFKTAEVDMRARALREAQVEAQRLVEATEAALVADGDLLDASERATVDALVASLRALAPGDDADAIDTATKALAEGTDEFAARRMDKSIKRALAGRKLDEI
What is the function of this protein?
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins.  Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
What are the official names of this protein?
Chaperone protein HscA homolog.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 70 family.
Protein: SYDC1_ARATH
Sequence: MVGSEVLEECGEKISKKESKKRAAKLEKLLRKQEREEATSSSLSLEEEDESCSSNYGDVTTNELQSAVEGKELTDVSNLVEEIVGSEVSIRGRLHKNRLVGTKLFVILRESGFTVQCVVEETRVGANMIKFVKQLSRESVVELIGVVSHPKKPLTGTTQQVEIHVRKMYCLSRSLPNLPLVVEDAARSESDIEKSGKDGKQAARVLQDTRLNNRVLDIRTPANQAIFRIQCQVQIAFREYLQSKGFLEIHTPKLIAGSSEGGSAVFRLDYKGQPACLAQSPQLHKQMAICGDMRRVFEVGPVFRAEDSFTHRHLCEFVGLDVEMEIRMHYSEIMDLVGELFPFIFTKIEERCPKELESVRKQYPFQSLKFLPQTLRLTFAEGIQMLKEAGEEVDPLGDLNTESERKLGQLVLEKYKTEFYMLHRYPSAVRPFYTMPYENDSNYSNSFDVFIRGEEIMSGAQRIHDPELLEKRARECGIDVKTISTYIDAFRYGAPPHGGFGVGLERVVMLLCALNNIRKTSLFPRDSQRLTP
What is the function of this protein?
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
What are the official names of this protein?
Aspartate--tRNA ligase 1, cytoplasmic, Aspartyl-tRNA synthetase, AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: FABV_XYLFA
Sequence: MIIHPKTRGFICTTTHPVGCEYNVLEQIQSTRARGVRSNGPKKVLVIGASSGYGLATRISAAFGFGADTLGVFFEKPGTEKKPGTAGWYNAAAFDKSAKNAGLYSRSINGDAFSDEMRAKVIEIIKSEMGGHVDLVVYSLASPLRKMPSTGEIKRSVLKPIGVAHISNAIDTNKDQIIQATVEPATEQEIADTVAVMGGQDWELWINALTQADVLAPQTRTVAFSYIGTEITWPIYWHGALGKAKADLDATSRRLDARLQALGGGANVAVLKSVVTQASAAIPALPLYIAIVFKVMKEKGLHEGTIEQADRLLRERLYREDGQPAAVDEEHRLRLDDWELREDVQATCKVIWKQVTNENLFQLTDYANYKRDFLKLFGFERADVDYDADVNPEVTFDVIEL
What is the function of this protein?
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II).  Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
What are the official names of this protein?
Enoyl-[acyl-carrier-protein] reductase [NADH], ENR.
What is the protein family that this protein belongs to?
Belongs to the TER reductase family.