PharMolix/UniProtQA huggingface dataset:
Protein: RS19_STRMK
Sequence: MARSLKKGPFVDHHLVKKVEAAAGSKKPIKTWSRRSMILPDMVGVTIAVHNGKNHIPVLVNENMVGHKLGEFAITRTFKGHGGDKKSGK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: KCNH6_RAT
Sequence: MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQRPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVIMFILNFEDLAQLLAKSSSRSLTQRLLSHSFLGSEGSHSRPSGQGPGPGRGKYRTVSQIPQFTLNFVEFNLEKHRSGSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAPRIHRGTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESQRGTCGYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEPKIGWLDSLGAQLGKQYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFRGASKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPASLHARPGKSSADVRALTYCDLHKIHRADLLEVLDMYPAFADTFWNKLEVTFNLRDADGGLQSTPRQAPGHQDPQGFFLNDSQSGAAPSLSISDTSALWPELLQQMPPSPPNPRQDLDCWHRELGFKLEQLQAQMNRLESRVSSDLSRILQLLQHPQGRPSYILGASASSDLASFPETSVTRSSESTLLVGHVPSAQTLSYGDLDDHIQTPRNFSPRTPHVAMAMDKTLVPSSEQEQPGGLLSPLASPLRPLEVPGLGGSRFPSLPEHLSSVPKQLEFQRHGSDPGFTRS
What is the function of this protein?
Pore-forming (alpha) subunit of voltage-gated potassium channel.  Elicits a slowly activating, rectifying current.  Channel properties may be modulated by cAMP and subunit assembly.
What are the official names of this protein?
Potassium voltage-gated channel subfamily H member 6, Ether-a-go-go-related gene potassium channel 2, ERG-2, Eag-related protein 2, Ether-a-go-go-related protein 2, Voltage-gated potassium channel subunit Kv11.2.
What is the protein family that this protein belongs to?
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y1949_VIBPA
Sequence: MSDLISYDDVIDAAYDIFLEMAPDNLEPADVILFTAQFEDRGAAELVETGEDWVEHVGFEVDKEVYAEVRIGLVNEENDVLDDVFARMLISRDPEHKFCHMLWKRD
What are the official names of this protein?
UPF0263 protein VP1949.
What is the protein family that this protein belongs to?
Belongs to the UPF0263 family.
Protein: OBG_KLEP7
Sequence: MKFVDEATILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWLEADENLNTLIDYRFEKSFRAERGQNGQSRDCTGKRGKDVTVKVPVGTRVIDQGTGETMGDMTKHGQRLMVAKGGWHGLGNTRFKSSVNRTPRQKTMGTPGDKRDLQLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDNEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGSDPVENARIIIGELEKYSEKLASKPRWLVFNKIDLMDKAEAEAKAKAIAEALGWEEKFYLISAASQQGVKELCWDVMTFIIENPIVQAEEEQKPEKVEFMWDDYHRQQLEEAEAEAEDDEDWDDDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL184_MIMIV
Sequence: MCDFVFCYGSSNERKLSKYIKDTKKGLRLYVSDREYFYVEIKKTNRKNLVISFEDSLKFMKFLVKKKIHCQLLNDKHSCGFCKNYRTYFQYIVQNKHVQYIKLFVGKFIPMIRSICEFVNFNLSYVIEDKQIFGNNNIDLEIVKYIFEIGNLIDVDYIVEYTLKTLDDVGIDLLEIFIGIYKQKITYFFTEDFGNIGDLLNTVLNMWAFIIPAFKTDNVNLFNYVVEELSNITDDINEEELDKNQIVSLNKIKQIYIYSELKIGVFLNTCIYNSFDCPNVFKQLMEDYVKDYLDIDSFAYNFFRKILDNNKFACAGILCEKINGNQRVLKNLLFYTVSTIDEARILVDYELDYEKIYEDPGFNKLAENTRKIIEQLVKETDN
What are the official names of this protein?
Uncharacterized protein L184.
What is the protein family that this protein belongs to?
Belongs to the mimivirus L17x/L18x family.
Protein: TWIST_PODCA
Sequence: MQEHQLSRVTSGNKKKYQSFDDESRDEKRMKCDSTDKLESNSNSKNIYQKTHRVIANIRERQRTQALNQSFSTLRKIIPTLPSDKLSKIQTLRLAAMYIDFLRHVIRRGEINMDSSDETFFSAQERLSYAFSVWRMEGDFYSRDKTAHYFTEQELNLCEYNFHSSFGNRLFYKAGIEAVNSADSDDITCILNTFLEGRI
What is the function of this protein?
Probable transcription factor, which may be responsible for the formation of myoepithelial cells in early muscle development in larva and the formation of non-muscle tissues in later bud stages and mesoderm-like structures in the medusa.
What are the official names of this protein?
Twist-related protein.
What are the subcellular locations of this protein?
Nucleus.
Protein: GPMA_SALPB
Sequence: MAVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGFSFDFAYTSVLKRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFAVTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNDTILPRMKSGERVIIAAHGNSLRALVKYLDNMSEDEILELNIPTGVPLVYEFDENFKPLKHYYLGNADEIAAKAAAVANQGKAK
What is the function of this protein?
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
What are the official names of this protein?
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, BPG-dependent PGAM, PGAM, Phosphoglyceromutase, dPGM.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
Protein: RF2_MYCLB
Sequence: MEPDRQTDIAALDSTLTTVERVLDVEGLRTRIEKLEHEASDPKLWDDQVRAQRVTSELSHAQGELRRIEELRRRLDDLPVLYELAAEERAAAAASGMEAFAEADAELKALRVDIEATEVRTLLSGEYDEREALITIRSGAGGVDAADWAEMLMRMYIRWAEQHKYGVEVLDTSYAEEAGVKSATFAVHAPFAYGTLASEQGTHRLVRISPFDNQSRRQTSFAEVEVLPVVEITDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHVPTGLVVTCQNEKSQLQNKVSAMRVLQAKLLERKRLEERAELDALKGRGGSSWGNQIRSYVLHPYQMVKDLRNEYEVGNPTAVLDGDIDGFLEAGIRWRNRRDIS
What is the function of this protein?
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
What are the official names of this protein?
Peptide chain release factor 2, RF-2.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ERS2_ORYSJ
Sequence: MDGSCDCIEPLWQADDLLVKYQYISDFFIALAYFSIPLELIYFVKKSAFFPYRWVLIQFGAFIVLCGATHLINLWTFAIYTKTIAVVLTVAKAATAVVSCITALMLVHIIPDLLNVKLRERFLKDKADELDREMGIIRTQEETGRHVHMLTHEIRSTLDRHTILRTTLVELGRTLVLAECALWMPTRSGSALQLSHTIYNSAAIGSVVPINLPIVSKVFNSNRVVKIPHTSPLASITADKSRYVPPEVVAIRVPLLHLTNFQINDWPELSAKSFAVMVLMLPPDSAREWRPHERELVEVVADQVAVALSHAAILEESMRARDLLMEQNIALDAARREAEMAICARNDFLAVMNHEMRTPMRAIVSLSSLLLETNLSAEQRLMVETILKSSDLLATLTNDVLDVSKLENGSLELEIAPFNLHSTFTDVVNLIKPVAACKRLSVMVTLAPELPLHAIGDQKRLMQIILNVAGNSIKFTKEGHVSITASMARPDALRGPHEPDYHPVVSDGFFYLAVQVKDTGCGISPQDMPHTFRKFAHPENAGKWNSGSGLGLALSRRFVSLMEGNIWLESEGVGKGCTAMFFVKLGMPEKPNANLRRMAPHPLQPNQGAGGPDALSISIMDSNPRVPRVRYQSSV
What is the function of this protein?
Ethylene receptor related to bacterial two-component regulators.  Acts as negative regulator of ethylene signaling.  May play a role in the regulation of flowering by up-regulating GI (GIGANTEA) and RCN1 and regulate starch accumulation by down-regulating the alpha-amylase AMY3D.
What are the official names of this protein?
Probable ethylene response sensor 2, OsERS2, Ethylene response factor 2.
What is the protein family that this protein belongs to?
Belongs to the ethylene receptor family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: GLND_CORGL
Sequence: MNNPAQLRQDTEKEVLALLGSLVLPAGTALAATGSLARSELTPYSDLDLILIHPPGATPDGVEDLWYPIWDAKKRLDYSVRTPDECVAMISADSTAALAMLDLRFVAGDEDLCAKTRRRIVEKWRQELNKNFDAVVDTAIARWRRSGPVVAMTRPDLKHGRGGLRDFELIKALALGHLCNLPQLDAQHQLLLDARTLLHVHARRSRDVLDPEFAVDVAMDLGFVDRYHLGREIADAARAIDDGLTTALATARGILPRRTGFAFRNASRRPLDLDVVDANGTIELSKKPDLNDPALPLRVAAAAATTGLPVAESTWVRLNECPPLPEPWPANAAGDFFRILSSPKNSRRVVKNMDRHGLWSRFVPEWDRIKGLMPREPSHISTIDEHSLNTVAGCALETVTVARPDLLVLGALYHDIGKGFPRPHEQVGAEMVARAASRMGLNLRDRASVQTLVAEHTAVAKIAARLDPSSEGAVDKLLDAVRYDLVTLNLLEVLTEADAKATGPGVWTARLEHALRIVCKRARDRLTDIRPVAPMIAPRSEIGLVERDGVFTVQWHGEDLHRILGVIYAKGWTITAARMLANGQWSAEFDVRANGPQDFDPQHFLQAYQSGVFSEVPIPALGITATFWHGNTLEVRTELRTGAIFALLRTLPDALWINAVTRGATLIIQAALKPGFDRATVERSVVRSLAGS
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism (By similarity).
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: RDS2_YEAST
Sequence: MSANSGVKRASKAFKTCLFCKRSHVVCDKQRPCSRCVKRDIAHLCREDDIAVPNEMPSQHESSPNDNNIQGKYANKAHTGIPSDYQNEPVNKSGSTYGEELSPKLDSSLVNDTTSLLLPQQPVFVSENVGSEFSSLNEFLSMLENPLLTQTSLSSSSASNVHLENGSQTTQSPLEYQNDNRRDEIGVARQENRSPTIMSGSSNSISKGDKQDQEKEESRILANANENSAPTPKEQFFLTAADPSTEMTPEHRLKLVINAKLEAGLLKPYNYAKGYARLQDYMDKYMNQSSKQRILKPLSTIRPAFRTIARSLKDVDLVLVEESFERMLLSYDRVFTSMSMPACLCRRTGEIYRANKEFASLVDCTVDDLRDGKLAIYELMTEESAVNFWEKYGSIAFDKGQKAVLTSCSLRTKDGIRKRPCCFSFTIRRDRYNIPICIVGNFIPLS
What is the function of this protein?
Transcription factor which regulates the expression of genes for gluconeogenesis, the TCA cycle, and glucose metabolism.  Involved in the cell wall remodeling process and drug resistance.
What are the official names of this protein?
Regulator of drug sensitivity 2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: USIP1_CAEEL
Sequence: MSSNLQLVETFDSRQFVVARWNRNDTTAMVPSAIAVVVFVESVEYKLGCKEKIGYSPTPEDQDQFMILQMESIDEANRICHDSIAKGFAINNTKIVFTPLLGLNGFRLQDAIDFMKTSQPHFNNDELLEVLTMAICQELPERLKILEDGFSFIEQGVSELIQNSACEMFGSFASPVRRNGYSDIDINVESVSAPGQRVSTNVRPLNEVVANPKCLITHPLTKSELETYPQEEIIKILYRCFNENSAFKTKFEMRFLPARTPIIVFKNIEVEGMNVSYDLSVHNQISVEKASLLHEFIVKDKSKGSRMKNAMMFIVHWAKSNKLLSGDYPEEKLEVKTKLNSYIINQLVIHFVQAATNKVHVNPQAKRDSRVNEYNFDTLFGDYCKFFRELFKYYANFDFTNKAIYGKKAMQKKTLSSAHGGVEESPLMLMDPMDITHNISAKVTEDAVKLLNGLIRNALFILKQNHFHINYLLETNTMATMLMKSREPKISISTRVTDGAEHQYLSVQLPAVVITSSDLFLLLTRVLRFNVCPNEQGPSVVDLCTPTGAIFLVTSRAWVGRRNTKRALKNSRHDLTPLQIDVMCSDKYDYEEDIAELRISMSTVPGTRIRLACIDIMRGQVSEVRDAIHFLIDQFINNNYDDLEKNGVQTISRIPIAAPTWP
What is the function of this protein?
Acts as a specific terminal uridylyltransferase for U6 snRNA.  Responsible for the addition of UTP at the 3' end of U6 snRNA which stabilizes U6 snRNA (PubMed:25753661).  Does not have activity towards modified uridine containing 3'-monophosphorylation or 2'-O-methylation (PubMed:25753661).
What are the official names of this protein?
U6 snRNA-specific terminal uridylyltransferase, TUTase, PAP-associated domain-containing protein, U6 snRNA-interacting protein.
What is the protein family that this protein belongs to?
Belongs to the DNA polymerase type-B-like family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: ML3_ARATH
Sequence: MAMSHVQPMLLLLVSLFFLPALRGAIDFEYCAKNGNDYGTVTSIVVSPSVGPHENPTITINLFGSASKNIPAGTLVYVAFRDGEFTGLLKTYNLCDVSACNNEAEIEAGTNFELTLSDVLYVGYDEEIKYSVSLRRKTLEEEDPIIKMCVDFKVPAPAPAFVSI
What is the function of this protein?
May be involved in herbivory-mediated responses.  May play a role in herbivory-associated molecular pattern (HAMP) recognition.  May function is jasmonate (JA) signaling in response to HAMP (PubMed:23314818).  May play a role in defense response against the pathogens Altenaria brassicicola and Pseudomonas syringae (PubMed:23903439).
What are the official names of this protein?
MD-2-related lipid-recognition protein 3.
What are the subcellular locations of this protein?
Vacuole. Endoplasmic reticulum. Note=Localized in endoplasmic reticulum bodies (ER bodies).
Protein: CTF18_HUMAN
Sequence: MEDYEQELCGVEDDFHNQFAAELEVLAELEGASTPSPSGVPLFTAGRPPRTFEEALARGDAASSPAPAASVGSSQGGARKRQVDADLQPAGSLPHAPRIKRPRLQVVKRLNFRSEEMEEPPPPDSSPTDITPPPSPEDLAELWGHGVSEAAADVGLTRASPAARNPVLRRPPILEDYVHVTSTEGVRAYLVLRADPMAPGVQGSLLHVPWRGGGQLDLLGVSLASLKKQVDGERRERLLQEAQKLSDTLHSLRSGEEEAAQPLGAPEEEPTDGQDASSHCLWVDEFAPRHYTELLSDDFTNRCLLKWLKLWDLVVFGHERPSRKPRPSVEPARVSKEATAPGKWKSHEQVLEEMLEAGLDPSQRPKQKVALLCGPPGLGKTTLAHVIARHAGYSVVEMNASDDRSPEVFRTRIEAATQMESVLGAGGKPNCLVIDEIDGAPVAAINVLLSILNRKGPQEVGPQGPAVPSGGGRRRRAEGGLLMRPIICICNDQFAPSLRQLKQQAFLLHFPPTLPSRLVQRLQEVSLRQGMRADPGVLAALCEKTDNDIRACINTLQFLYSRGQRELSVRDVQATRVGLKDQRRGLFSVWQEVFQLPRAQRRRVGQDPALPADTLLLGDGDAGSLTSASQRFYRVLHAAASAGEHEKVVQGLFDNFLRLRLRDSSLGAVCVALDWLAFDDLLAGAAHHSQSFQLLRYPPFLPVAFHVLFASSHTPRITFPSSQQEAQNRMSQMRNLIQTLVSGIAPATRSRATPQALLLDALCLLLDILAPKLRPVSTQLYSTREKQQLASLVGTMLAYSLTYRQERTPDGQYIYRLEPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVENSPQVDGSPPGLEGLLGGIGEKGVHRPAPRNHEQRLEHIMRRAAREEQPEKDFFGRVVVRSTAVPSAGDTAPEQDSVERRMGTAVGRSEVWFRFNEGVSNAVRRSLYIRDLL
What is the function of this protein?
Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission.  Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5.  The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA).  The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA.  Interacts with and stimulates DNA polymerase POLH.  During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage (PubMed:20227374).
What are the official names of this protein?
Chromosome transmission fidelity protein 18 homolog, hCTF18, CHL12.
What is the protein family that this protein belongs to?
Belongs to the activator 1 small subunits family. CTF18 subfamily.
What are the subcellular locations of this protein?
Nucleus. Note=Associates with chromatin during S phase.
Protein: RIMO_SALAI
Sequence: MVSATSASPADGRRVALLTLGCARNEVDSEELAARLHADGWQVTTDGEGAEVVVVNTCGFVEKAKQDSIQTLLAAAETGAKVVAAGCMAERYGRELADSLPEAQAVLSFDDYPDISDRLGAVLAGTAIDAHTPRDRRELLPLTPVRRREAAVSLPGHGTRAAAAGPGGRSAPVEVDEHTPAHLRPVLRRRLDTGPVASLKLASGCDRRCAFCAIPAFRGAFVSRPPEELLAEAEWLARTGVRELVLVSENSSSYGKDLGDPRALEKLLPQLAAVDGIVRVRASYLQPAETRPGLVEAIATTPGVAAYFDLSFQHSSEPVLRRMRRFGSTERFLDLLASVRALAPEAGARSNFIVGFPGETRADVAELVRFLNEARLDAIGVFDYSDEDGTEAAGLSGKVSATTVKRRYDRLGALADELCAQRAEQRLGSTVQVLVDSVDDGVVEGRAAHQAPEVDGSTTLVAPSGGGVDLAALRPGDLVRCTVTATEGVDLVAVPDGMISAAPGVAR
What is the function of this protein?
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
What are the official names of this protein?
Ribosomal protein S12 methylthiotransferase RimO, S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. RimO subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y935_PELPB
Sequence: MRIHDFDPDNRPRERLLRSGAASLSPAELLAIILRTGTKNLNIVDTCNELIARYSLEKLANITLEELKKVKGIGDAKAMQIVAIFELNKRLHYSRNLNKKIQAARDVFEYMAGRVPDETKEHLFVLHLNTKNQIIKTELVSVGTLNAALIHPREVFKSAIKESSHAIILVHNHPSGDVEPSNADKQVTDLLKQASTVIQIDLLDHIIIGKTGCFSFRESGLL
What are the official names of this protein?
UPF0758 protein Ppha_0935.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: CTAA_STAAB
Sequence: MFGKKNLKWLGVVATLMMTFVQLGGALVTKTGSADGCGSSWPLCHGALIPEFFPIDTIIELSHRAVSALSLLMVLWLVITAWKHIGYIKEIKPLSIISVGFLLLQALIGAAAVIWQQNDYVLALHFGISLISFSSVFLITLIIFSIDQKYEAAELYIKKPLRRLTWLMAIIIYCGVYTGALVRHADASLAYGGWPLPFHDLVPHSEQDWVQLTHRIMAFIVFTIIMITYIHAVKNYPNNRTVHYGYTAAFILVILQVITGALSIMTNVNLIIALFHALFITYLFGMTTYFIMLMLRSVRSDKQ
What is the function of this protein?
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8.  The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
What are the official names of this protein?
Heme A synthase, HAS, Cytochrome aa3-controlling protein.
What is the protein family that this protein belongs to?
Belongs to the COX15/CtaA family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PB2_INCBE
Sequence: MSLLLTIAKEYKRLCQDAKAAQMMTVGTVSNYTTFKKWTTSRKEKNPSLRMRWAMSSKFPIIANKRMLEEAQIPKEHNNVALWEDTEDVSKRDHVLASASCINYWNFCGPCVNNSEVIKEVYKSRFGRLERRKEIMWKELRFTLVDRQRRRVDTQPVEQRLRTGEIKDLQMWTLFEDEAPLASKFILDNYGLVKEMRSKFANKPLNKEVVAHMLEKQFNPESRFLPVFGAIRPERMELIHALGGETWIQEANTAGISNVDQRKNDMRAVCRKVCLAANASIMNAKSKLVEYIKSTSMRIGETERKLEELIPETDDVSPEVTLCKSALGGPLGKTLSFGPMLLKKISGSGVKVKDTVYIQGVRAVQFEYWSEQEEFYGEYKSATALFSRKERSLEWITIGGGINEDRKRLLAMCMIFCRDGDYFKDAPATITMADLTTKLGREIPYQYVMMNWIQKSEDNLEALLYSRGIVETNPGKMGSSMGIDGSKRAIKSLRAVTIQSGKIDMPESKEKIHLELSDNLEAFDSSGRIVATILDLPSDKKVTFQDVSFQHPDLAVLRDEKTAITKGYEALIKRLGTGDNDIPSLIAKKDYLSLYNLPEVKLMAPLIRPNRKGVYSRVARKLVSTQVTTGHYSLHELIKVLPFTYFAPKQGMFEGRFFFSNDSFVEPGVNNNVLSWSKADSSKIYCHGIAIRVPLVVGDEHMDTSLALLEGFSVCENDPRAPMVTGQDLIDVGFGQKVRLFVGQGSVRTFKRTASQRAASSDVNKNVKKIKMSN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus.
Protein: GPDA_NITEC
Sequence: MNITVLGAGAWGTALAIYLSARHHVTLWTRNTGHLAELAALRVNQRYLPGQHLPDSIHLASALSDALEQAELVLVVVPVAGLRVTLQRIAALNQSLPLVLGCKGFEAGTAKLPCQVVEDVYSAEITCGVLSGPSFAQEVAMGLPAALTLASDDDAFARRIASEIHTSILRVYSSSDVVGVEVGGALKNVIAIAAGISDGLAFGNNARAALITRGLAEITRLGVALGGHRKTFTGLSGIGDLILTCTGDLSRNRQVGMMLAAGCQLPEILLEIGHVTEGVYTVREAHEMGRQLQIDMPVTQAVYSILYEQIPVESAIRNMLDREPGAETD
What are the official names of this protein?
Glycerol-3-phosphate dehydrogenase [NAD(P)+], NAD(P)H-dependent glycerol-3-phosphate dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EX7L_PSEAB
Sequence: MRNDPFQRLGLDREVLTVSQLNQRARLLLEDVFPQVWVEGELSNLARPASGHVYFTLKDSNAQIRCALFRQNALRVRQALRDGLAVKVRGKISLFEGRGDYQLIADTVEPAGDGALRLAFEALKEKLAGEGLFASERKRPLPAHPRRIGIVSSPSGAVIRDIISVFRRRAPQVELTLVPTAVQGREAVAQIVRALQLADRQGFDALILARGGGSLEDLWCFNEEAVARAVAACATPIVSAVGHETDVSISDFVADVRAPTPSAAAELLAPNAGDLQQRLDGLRRRLVLRMRDQLLRERLRLEGVARRLRHPGERLRQQAQRLDDLDMRLRRAFERHLAVRHERLVRLETRLAAQHPGRTLALLRQKLDSLAARLPRAAREVLKDRRQHLEGLAQTLNVVSPLATLGRGYSILLDERGRAIRDAGQTQPGQRLKARLAEGELEVRVEDNHRTPVTLSLLD
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 large subunit, Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit.
What is the protein family that this protein belongs to?
Belongs to the XseA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SUCC_MANSM
Sequence: MNLHEYQAKQIFAQYGLPVSEGCACQSLEEAIQAVKKLGGGQWVAKCQVHAGGRGKAGGVKLVKSEEEVRSFFEKFLGQRLVTFQTDAKGQPVNAIYMEACANVKKELYLGAVLDRSSQRIVFMVSTEGGVNIEEVAEKTPHLLHKMPIDPLVGAMPYQGRELAFKLGLQGKQIQQFAQIFCQLGKMFVEKDLSLLEINPLVILDNDQLHCLDAKIVVDGNALYRQPELNAMRDPSQEDAREAAAEQWHLNYVALEGNIGCMVNGAGLAMGTMDIVKLHGGQPANFLDVGGGTTKERVAEAFKIILSDQSVKAILVNIFGGIVRCDLIAEGIVAAVNEVGVSVPVVVRLEGNNAPLGREILAQSGLNIIAATSLTDAAVQVVNAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: NRDR_PSELT
Sequence: MKCPFCGHPDSRVLDSRPTLDGTAIRRRRECIECGARFTTYERYELLPIIVVKKDGRRETFDRSKLLNGVLKACEKRPISYETLEKLVEEVELALQKQGSTEIPSKLIGELVMSKLRQIDQVAYVRFASVYKDFREIDQFLDIVRELKKDQEVD
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: CIDB_STAA8
Sequence: MNDYVQALLMILLTVVLYYFAKRLQQKYPNPFLNPALIASLGIIFVLLIFGISYNGYMKGGSWINHILNATVVCLAYPLYKNREKIKDNVSIIFASVLTGVMLNFMLVFLTLKAFGYSKDVIVTLLPRSITAAVGIEVSHELGGTDTMTVLFIITTGLIGSILGSMLLRFGRFESSIAKGLTYGNASHAFGTAKALEMDIESGAFSSIGMILTAVISSVLIPVLILLFY
What is the function of this protein?
Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation.  Inhibited by the antiholin-like proteins LrgAB.  In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins.  When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability.  These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential.
What are the official names of this protein?
Holin-like protein CidB.
What is the protein family that this protein belongs to?
Belongs to the CidB/LrgB family. CidB subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CARB_STRT1
Sequence: MPKRSDIKKIMVIGSGPIIIGQAAEFDYAGTQACLALKEEGYSVVLVNSNPATIMTDKEIADKVYIEPITLEFVTRILRKERPDALLPTLGGQTGLNMAMELSKAGILDELGVELLGTKLSAIDQAEDRDLFKQLMEELEQPIPESEIVNTVEEAVAFATEIGYPVIVRPAFTLGGTGGGMCANEEELREIAENGLKLSPVTQCLIERSIAGFKEIEYEVMRDAEDNALVVCNMENFDPVGIHTGDSIVFAPTQTLSDIENQMLRDASLKIIRALKIEGGCNVQLALDPHSFKYYVIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMINPVTGTTYAMFEPALDYVVAKIPRFPFDKFEHGERRLGTQMKATGEVMAIGRNIEESLLKACRSLEIGVYHNEMSELAEVTDDALVEKVVKAQDDRLFYISEAIRRGYTIEELSELTKIDIFFLDKLLHIFELEQELAAHVGDVDVLKEAKRNGFSDRKIADLWNQTANQVRATRLENNIVPVYKMVDTCAAEFESSTPYFYSTYEWENESIKSDKESVIVLGSGPIRIGQGVEFDYATVHSVKAIQAAGYEAIIMNSNPETVSTDFSVSDKLYFEPLTFEDVMNVIELEQPKGVVVQFGGQTAINLAEPLSKAGVKILGTQVADLDRAEDRDLFEQALKDLDIPQPPGQTATNEEEAVEAARKIGFPVLVRPSYVLGGRAMEIVENEDDLRSYMRTAVKASPDHPVLVDSYIIGRECEVDAISDGKDVLIPGIMEHIERAGVHSGDSMAVYPPQTLSKKIQETIADYTKRLAIGLNCIGMMNIQFVIKDETVYVIEVNPRASRTVPFLSKVTDIPMAQVATNLILGKSLAEQGYKDGLYPESNHVHVKAPVFSFTKLAQVDSLLGPEMKSTGEVMGTDVTLEKALYKAFEASYLHLPTFGNVIFTIHDDTKEEALDLARRFDAIGYGIYATEGTAKFLNEHGVHATLVNKLGENDDNDIPALVRTGKAQAIINTVGNKRTYDEDGAAIRSSAIEAGIPLFTALDTADAMVRVLESRSFTTEAI
What are the official names of this protein?
Carbamoyl-phosphate synthase large chain, Carbamoyl-phosphate synthetase ammonia chain.
What is the protein family that this protein belongs to?
Belongs to the CarB family.