PharMolix/UniProtQA huggingface dataset:
Protein: P53_CANLF
Sequence: MEESQSELNIDPPLSQETFSELWNLLPENNVLSSELCPAVDELLLPESVVNWLDEDSDDAPRMPATSAPTAPGPAPSWPLSSSVPSPKTYPGTYGFRLGFLHSGTAKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVTEVVRRCPHHERCSDSSDGLAPPQHLIRVEGNLRAKYLDDRNTFRHSVVVPYEPPEVGSDYTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNVLGRNSFEVRVCACPGRDRRTEEENFHKKGEPCPEPPPGSTKRALPPSTSSSPPQKKKPLDGEYFTLQIRGRERYEMFRNLNEALELKDAQSGKEPGGSRAHSSHLKAKKGQSTSRHKKLMFKREGLDSD
What is the function of this protein?
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.  Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.  One of the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.  Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity).  However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity).  In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.  Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.  Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1.  LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation.  Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.
What are the official names of this protein?
Cellular tumor antigen p53, Tumor suppressor p53.
What is the protein family that this protein belongs to?
Belongs to the p53 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (By similarity).
Protein: HSLU_HALH5
Sequence: MKNVLTPRQIVERLDQYIVGQEGAKRSVAIALRNRYRRFQLEDKLRDEITPKNILMIGPTGVGKTEIARRLAKLVGAPFVKVEATKFTEVGYVGRDVESMIRDLVETSVRLVKEEKMKGVKKQAEEQANQRIVELLVPAKKKTQAYKNPLEMLFGQQQENTDHQETSAEQDTLTERRRRMSHQLALGELEDHYVTVEVEEQTPQFFDMLQGSGMEQMGMNMQEMLGNMMPKKRKKRKLTVREARRVLTEEEAQKLIDMDEVTQEAVSKAEQLGIVFIDEIDKIAGKGQQSADVSREGVQRDILPIVEGSTVVTKYGPVSTDHMLFIGAGAFHVAKPSDLIPELQGRFPIRVELSNLTVDDFVRILVEPDNALLKQYAALLETEGIKIVFTDEAVHKIATIATEVNQETENIGARRLHTLLERLLEDLSFEAPDVNLEEIVITPEYVTEKLAAIAKNRDLSQYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
Protein: RS7_GEOSE
Sequence: MPRRGPVAKRDVLPDPIYNSKLVTRLINKIMIDGKKSKAQKILYTAFDIIRERTGKDPMEVFEQALKNVMPVLEVRARRVGGANYQVPVEVRPDRRVSLGLRWLVQYARLRNEKTMEERLANEIMDAANNTGAAVKKREDTHKMAEANKAFAHYRW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.  Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity).
What are the official names of this protein?
30S ribosomal protein S7, BS7.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS7 family.
Protein: PGK_PSELT
Sequence: MKKLTIKDIDLSNKAVIMRVDFNVPIGKDGKVSDDTRITAALPTIKYAVEKKAKVILLSHLGRPKGSFDPKYSLKPIAEHLKNISGLNVIFVPHVVGEEVKEAVKNMKVGDVLLLENTRFHPGEEKNDQELAKAWAELADIHVNDAFGTAHRAHASNVGIANFIPSVAGFLMEKEIDFLNKVTYEPDHPYVVVLGGAKVSDKIGVITNLLNKADKLLIGGAMMFTFLKAQGLKVGSSLVENDKLDLAKQILEQAKEKKVEIVLPVDAIVAQKIEAGVEKKTADLKDGIDDGWMGLDIGPKTIKVFEEALKNAKTVVWNGPMGVFEIEDFAGGTKAVAEMIAKIKGTTVIGGGDSAAAVAKFGLESAYSHVSTGGGASLEFLEGKDLPGIRSIADKKK
What are the official names of this protein?
Phosphoglycerate kinase.
What is the protein family that this protein belongs to?
Belongs to the phosphoglycerate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRG_FRAT1
Sequence: MNSNTKIIFVTGGVVSSLGKGVTAASLATLLESRGLNVTMMKLDPYINVDPGTMSPLQHGEVFVTEDGAETDLDLGHYERFIRNKMTQANNFTTGKVYQSVLRRERKGDYLGATIQVIPHITDEIKRRICSGIADDVDVAIVEIGGTVGDIESQPFLEAIRQLRIELGRNRTLFVHLTLLPYIKVAGEIKTKPTQHSVKELRGIGIQADVLVCRCEKKFDDSEKRKIALFTNVDQDCIFTAEDVDTIYEVPLKYNQQGFDAKLVELLNLNAKEADLSEWQNVVNTIRDVKGEVTIAMVGKYVSLTEAYKSLNEALYNAGYKKGVKVKIKFVDSEDVNENNVESYFKDVAAILVPGGFGSRGVEGKIISIKYARENQIPFLGICLGMQLAVIEYARNILGIKDAHSSELEPTTANPVIGLITEWQAEDGTVHQRTHSSDLGGTMRLGGYKCVLKQGSRAREIYQADEVVERHRHRYEVNSNYVERLEEAGLIFSGRSEDNKLMELIEIPQHKWFIACQAHPEFTSTPRYGHKLFESYIQAAIENSNN
What is the function of this protein?
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.  Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
What are the official names of this protein?
CTP synthase, Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase.
What is the protein family that this protein belongs to?
Belongs to the CTP synthase family.
Protein: PUR5_NEIM0
Sequence: MSTSLSYRDAGVDIDAGDQLVENIKPFAKRTMRPEVLGDLGGFGALVEIGKKYKNPVLVSGTDGVGTKLKLAFDWDKHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVPRATDVIKGIAQGCEESGCALIGGETAEMPGMYPVGEYDLAGFAVGVVEKENVITGRSIGAGDVVLGLASNGAHSNGYSLIRKIIERDNPDLDAEFDNGKTLREAVIAPTRLYVKPILAALEKFTIKGMAHITGGGITENVPRVLPENTVAQIDAKSWELPKLFQWLQKAGNVETQEMYRTFNCGIGMVVIVAAEDADAVQGLLGEQGETVYRLGLIRERQGDEHQTQVA
What are the official names of this protein?
Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase.
What is the protein family that this protein belongs to?
Belongs to the AIR synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ESTE_HVAVE
Sequence: MCKSRLPTVLSLTLIYISISIGFSVYFYVLMEAAYDQFSSMFESYTQTAVHLQSNSRTLKSDLSDYMQLLNYSRKFDESGEESVLRRHNITTPRVFYIDLNYTTALGAENRNLNMINFYAIPYRYVDLLDPFGNSIPVTGRTPATEYIDCSRDKKEKCIDSIPPFDGVLDCLSLDIHMQPWSRNNKSFNRPIIIWLGEVAGELWRLVAGGLIVIRANYRRGCYGFLCHHDQSLPYRNQGVNDVLHAIDWTIENARHFAGDISKITLAGHGASASLVEYIRLNHGHHLPLDKYIVMSANNFGSRDLYCSSNSNVMVTTARLLGMPPSPATESGKERSVYESVRYLSFVEPKLVMSKLYGLKAAFHPCPLSVNNRRASTFGIGFKTKNHTSSNCIRTANEQPVLFTNTLNEYHNFVYGSTVFTHARSETILRTIGDMLSRHFIESRLAYANSSTEKLIQQVNGQYNVVDGEFVDYDAFIRLLTDFAFIMPTVKMNEFTTECGGNSYHYVFDFGNSTHGDDLKMLTSSANDTSLTHFQRQLADGLGFILSKFVRRGYPVKKQDGWCPSTGLVAQIMEMNTKDENVVVKKSTEGVLIPLLNQSYVLHFHRVSVAKQKCYNRLGNVPFWNDLLKFHQSARRGWRDGDTGCARSKYLSEIV
What are the official names of this protein?
Putative esterase.
What is the protein family that this protein belongs to?
Belongs to the type-B carboxylesterase/lipase family.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: RL27_RHOPA
Sequence: MAHKKAGGSSRNGRDSAGKRLGVKAFGGEHVIPGNIIARQRGTQWHPGLNVGMGTDHTLFAKVEGRVEFRAKANGRTYVSVLPIAMQAAE
What are the official names of this protein?
50S ribosomal protein L27, RRP-L27.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL27 family.
Protein: LET12_SOLLC
Sequence: MEFQDHFSQEMVLHQQQQQQQQQQNAVLRSMLPESPHHDARKSPPTWLNTSLLRQQHSQFGNASSPSSAAAAAAVAGGNNFLHLQTSNSDSSNSNQWLSPTAAAGGGSNGGGSGHNDELSESMNFAKKMSQQHSGGGEENNNNNNNNNNNNNEEENSWEREKCKADILNHPLYDQLLSAHVSCLRIATPVDQLPRIDAQLAQSQNVVAKYSVLGQGQPPLDDKDLDQFMTHYVLLLSSFKEQLQQHVRVHAMEAVMACWELEQSLQSLTGVAPGEGTGATMSDDDDDQADSDTNFLDGGFDGPDSMGFGPLVPTESERSLMERVRQELKHELKQGYKEKIVDIREEILRKRRAGKLPGDTTSVLKAWWQSHSKWPYPTEEDKARLVQETGLQLKQINNWFINQRKRNWHSNPSTSSSQKSQTQECR
What is the function of this protein?
May have a role to play in formative events in ovule and embryo morphogenesis.
What are the official names of this protein?
Homeobox protein knotted-1-like LET12.
What is the protein family that this protein belongs to?
Belongs to the TALE/KNOX homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: YDIB_ECO8A
Sequence: MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPGAIEGLKALKMRGTGISMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMKPLENESLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA
What is the function of this protein?
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate.  Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively.  It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.
What are the official names of this protein?
Quinate/shikimate dehydrogenase, NAD-dependent shikimate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: XYNB_TALPU
Sequence: MKVTAAFAGLLATTLAAPATELVTRSINYVQNYNGNLGAFSYNEGAGTFSMYWQQGVSNDFVVGLGRSTGSSNPITYSASYSASGGSYLAVYGWVNSPQAEYHVVEAYGNYNPCSSGSATNLGTVSSDGGTYQVCTDTRVNQPSITGTSTFTQFFSVRQGSRTSGTVTIANHFNFWAKHGFGNSNFNYQVVAVEAWSGTGTASVTVSA
What is the function of this protein?
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
What are the official names of this protein?
Endo-1,4-beta-xylanase B, Xylanase B, 1,4-beta-D-xylan xylanohydrolase B.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 11 (cellulase G) family.
What are the subcellular locations of this protein?
Secreted.
Protein: 2A5D_RABIT
Sequence: MSPSPSSSGKDGGGENAEEAQPQPQPQPQPQPQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL
What is the function of this protein?
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
What are the official names of this protein?
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform, PP2A B subunit isoform B'-delta, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-delta, PP2A B subunit isoform PR61-delta, PP2A B subunit isoform R5-delta.
What is the protein family that this protein belongs to?
Belongs to the phosphatase 2A regulatory subunit B56 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: RS27L_HUMAN
Sequence: MPLARDLLHPSLEEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH
What are the official names of this protein?
40S ribosomal protein S27-like, Small ribosomal subunit protein eS27-like.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS27 family.
Protein: FADA_HAHCH
Sequence: MSLNPRDVVVIDCVRSPMGRAKAGCFRNVRAETLSATLIDALFDRNDKVDPAEVEDLIWGCVNQTLEQGFNVARQISLLTRIPHTSSAQTVNRLCGSAMSAIHTAAQAIMTGNGDVFVVGGVEHMGHVPMTQGFDHNPAASKYSAKASNMMGLTAEMLAKMHGISRQQQDEFGARSHRLAHEATLEGRFRNEIISIQGHDDDGFPALIENDETIRPETTAESLAQLRPAFDPKSGTVTAGQSSQLTDGASAMLLMSAERAQALGLTPMAKIRSMATAGCDPAIMGYGPVPATKKALKRAGLKVEDIDFWELNEAFAAQSLPVIKDLKLMGVVDQKVNLNGGAIALGHPLGCSGARISTTLLNVMAAKGGTLGVSTMCIGLGQGIATVWERI
What is the function of this protein?
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
What are the official names of this protein?
3-ketoacyl-CoA thiolase, Acetyl-CoA acyltransferase, Beta-ketothiolase, Fatty acid oxidation complex subunit beta.
What is the protein family that this protein belongs to?
Belongs to the thiolase-like superfamily. Thiolase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PURA_CAMLR
Sequence: MSKADIVVGIQWGDEGKGKIVDKLCENYDYVCRSAGGHNAGHTIWVDGIRYALHLMPSGVLNKQCINVIGNGVVVNPDVLISEMAQFENLEGRLFISDRAHLNLNHHALIDQARERLKGDKAIGTTGKGIGPSYEDKISRNGHRVGELLEPEKLCENLMKDFELKKTYFDVLGIAMPSYDEILKDLKRFKEVLAPYITDTTRMLWKALDEDKKVLLEGAQGSMLDIDHGTYPYVTSSTTISAGALSGLGLNPKEIGKVIGIVKAYTTRVGNGAFPSEDLGEDGEKIGLIGKEIGVSTGRKRRCGWFDAVAVRYTARLNGLDTLSLMKLDVLDGFESVKICKAYEYKGQEIDYVPCDLENAKPIYEVMEGWDKVAGIRDYDLLPENAKKYIKRLEELSGVKVGYISTSPEREDTIIL
What is the function of this protein?
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.  Catalyzes the first committed step in the biosynthesis of AMP from IMP.
What are the official names of this protein?
Adenylosuccinate synthetase, AMPSase, AdSS, IMP--aspartate ligase.
What is the protein family that this protein belongs to?
Belongs to the adenylosuccinate synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: F234A_BOVIN
Sequence: MTDGKDLEAEIHPLKSENRKVPENAGALAGKEPRGTPAPQTRLSHCRTAAFFLSLFACLLVVFVVSFIIPCPDRPALQGVWRIDYNAAVAYDFLAAEDVNKDKIQDILFLYKNTNSSRGNSSFSCADEGFSCPCTFVAAVSGASGSVLWERPVAQDRAFVECGILQPRGSAAPSACVVLGRPGSLVAVDTLTGKTLWSQPSSFGGNASVLSPLLRVPDLDADGAPDLLVLIQEENQVNGSIYSGGTGQQVSPPDSLGVDGTSGSILHVTRAGAHYVLIPCGTALCSRSVKGLYEKVSRRDSPLKSDPLWEDMLSAASHRLVVHSSGAIRYLMNVPGKAGDDLLLVSTEAYMLLDGQDLTPRWTFGTTQVLRKPVLGYYKPDTPAVLVENGTGPDRQVLLLDLGSGAVLWSQALPGLPGDPPSASLPTADHRSAFFFWGIHEPTDSNQTEPGAAGRRLYMLHPTLPGVLLELDNVSVPIVAFQVVLLEPGRHAACILLTGPASPSPPGLVSVTKHKVQDLVLAGRVVHLAEGGAESDQAVRDRLSRLRYRSEA
What are the official names of this protein?
Protein FAM234A, Protein ITFG3.
What is the protein family that this protein belongs to?
Belongs to the FAM234 family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: RK14_CITSI
Sequence: MIQPQTHLNVADNSGARELMCIRIIGASNRRYAHIGDVIVAVIKEAVPNTPLERSEVIRAVIVRTCKELRRDNGMIIRYDDNAAVVIDHEGNPKGTRVFGAIARELRQLNFTKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: Y1169_SULIK
Sequence: MSYLVVTIKVILITGMPGSGKSEFAKLLKERGAKVIVMSDVVRKRYSIEAKPGERLMDFAKRLREIYGDGVVARLCVEELGTSNHDLVVFDGVRSLAEVEEFKRLLGDSVYIVAVHSPPKIRYKRIIERLRSDDSKEISELIRRDREELKLGIGEVIAMADYIITNDSNYEEFKRRCEEVTDRVLKNG
What are the official names of this protein?
UPF0200 protein M164_1169.
What is the protein family that this protein belongs to?
Belongs to the UPF0200 family.
Protein: RS12_EHRRG
Sequence: MPTINQLVRSPRKSRALLNKAPALQHNPQKRAVCVKVYTTTPRKPNSALRKVARVKIAGYGSEVIAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGALDSRGVQNRKKARSKYGVKKS
What is the function of this protein?
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone.  Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together.  The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S12.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS12 family.
Protein: CPSF1_BOVIN
Sequence: MYAVYKQAHPPTGLEFSMYCNFFNNSERNLVVAGTSQLYVYRLNRDSEAPTKNDRSTDGKAHREHREKLELVASFSFFGNVMSMASVQLAGAKRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLIYGTRLVVLPFRRESLAEEHEGLVGEGQRSSFLPSYIIDVRALDEKLLNIVDLQFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIGGVVIFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQAAFISYDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSLLLKYTEKLQEPPASTAREAADKEEPPSKKKRVDATTGWSGSKSVPQDEVDEIEVYGSEAQSGTQLATYSFEVCDSILNIGPCANAAMGEPAFLSEEFQNSPEPDLEIVVCSGYGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEQEETLKGEGTEPEPGAPEAEDDGRRHGFLILSREDSTMILQTGQEIMELDASGFATQGPTVFAGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGSPIVQCAVADPYVVIMSAEGHVTMFLLKNDSYGGRHHRLALHKPPLHHQSKVITLCVYRDVSGMFTTESRLGGVRDELGGRGGPEAEGQGAETSPTVDDEEEMLYGDSGSLFSPSKEEARRSSQPPADRDPAPFRAEPTHWCLLVRENGAMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEARKEEATRQGELPLVKEVLLVALGSRQRRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGGSTEEGTGPRGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMGIDGPIDSFAPFHNINCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTSTPCTRVPRMTGEEKEFETIERDERYVHPQQEAFCIQLISPVSWEAIPNARIELEEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGAAEGPSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRVLQNAVRNVLDGELLNRYLYLSTMERGELAKKIGTTPDIILDDLLETDRVTAHF
What is the function of this protein?
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition.  This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).  May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity).
What are the official names of this protein?
Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor 160 kDa subunit, CPSF 160 kDa subunit.
What is the protein family that this protein belongs to?
Belongs to the CPSF1 family.
What are the subcellular locations of this protein?
Nucleus, nucleoplasm.
Protein: PHSB_STRVT
Sequence: MTAPQTDDVVTGRIAAIWAGLLDRPEIGIDDNVFRLGASSVMAVRAAARIREALDTPLPLRDVFESPSPAALAKRIRASRSTAPTASGPPRTAPVDSTATAPLTFQQEPMWLFDRMQPGNATYTIHFALRHEGHLDLGVLDRCVRDVVRRHAVLRTVFPSVDDRPAQQVLDRAHIPLGESDLRALPEAERPVAAARIAAREAQAPFDLSTGPMLRVRVLHLSDTRQRLLLTMPHIVTDAWSDDILVRELNHLYRAHTDGIAPALPPLPVQYHDWAARQRAELAGTEAELLDWWRHHLAGVPPLLELPADRPRAAVKRHRGGRLLFDIPESVTRRLEGLAKDEGTTPYAVLLAGFAALLHRLTGQDDLLVGSPVAGRTHTETEGLVGLFVNTVAVRCDVAGRPSFLELVRRTRRTVVESFARQELPFHRLVEELAPVRSPAYTPLVQVMLALQNTPDRDGREPGEGPFAREESGGDTGSAMFDLTLFVTGSASGMRGEWEYDSDLFDRERVAELGPQLVTLLDAALDRTDLPVALLPLQEPAARDRMVQAWNDTADVLPGGPDADSLPALLSAQAHRTPDAVALRTDDGAELTYRQLHLRADRLARRLLSYGLAPESVVAVACERSFEMVVALLAVLKAGCAYLPIDPGDPAERTAYLLRDSGARVLLTLHRHTANLPDADGTTVVTLDEPDPSGDMQDTTSALPGIAPGQLAYLIYTSGSTGRPKGVLNEHGPVCNRIRWGMRAFPPGPGTIVLQKTPIHFDVSVWEMFWTLATGATLVLARPDGHRDPQYLAGRLVEEGVTDVHFVPSMLAAFLDVGALPEGHSLRRVFCSGEALSPGLRDRLFARLPHVELHNLYGPTEAAIEVTHWRCRPGEPTVPIGRPIANARCYVLDAELNPVPPGVPGELWLGGVPVARGYHGRADLTAERFLPDPYGPAGSRMYRSGDLARWRRDGVLEYLGREDGQVKLRGQRLELGEIEATLAGHAEVADVVVDVRGTGPQDRRLVAYVRPARPGRDEQLRTTLRELAAARLPAYMRPSSYVTLDRVPLTPSGKTDRKALPDPAAGEQPRSGRGAAPGTPAERELAGIWAELLGAGEVGGDDNFFEIGGHSLLAARMTGRASTAFGVDLPVSLAFEHPVLRDFALAVVTAQAATDSAATERLLAELEALADTELEALPDEDGPDGRSGE
What is the function of this protein?
Involved in the biosynthesis of the antibiotic phosphinothricin tripeptide (PTT), which has bactericidal, fungicidal and herbicidal properties (PubMed:16251301).  Adenylates L-alanine and loads it onto a peptidyl carrier domain via a thioester linkage to the phosphopanthetheine moiety (PubMed:16251301).  Shows weaker activity with aminobutyric acid and L-serine (PubMed:16251301).
What are the official names of this protein?
Phosphinothricin tripeptide synthase PhsB, PTT synthase PhsB, L-alanine--[L-alanyl-carrier protein] ligase, Nonribosomal peptide synthase PhsB, Phosphinothricin tripeptide synthetase III, PTT synthetase III.
What is the protein family that this protein belongs to?
Belongs to the NRP synthetase family.
Protein: OADC_RHOP2
Sequence: MAWRDRRGALRAILEGSACVRPASVYDAISIRIADDLRFPLGMFGGSVASLAILGDPDSALITLTELAEQMRRMARAAALPVLVDADHGYGNALNVRRTVQELEAAGCAGLTIEDTLLPQAYGEAKPQLISSEEGLGKINAALDARLDPSLVIIGRTGACSISSLDDAIERAVAYEAAGVDALFFTGVKARDQLQAISAATRLPIVLGSPPAELADWEYLAAQRVRIAVQGHAPIAAATEAVFRTLSALRDGAAPQQLTGLATPELMDRVTRASLVDERGARFLGLARE
What is the function of this protein?
Catalyzes the decarboxylation of oxaloacetate into pyruvate.  Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate.
What are the official names of this protein?
Oxaloacetate decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family.
Protein: ACYP_METAR
Sequence: MKAVDVLISGRVQKVGYRAFTRKNALLLGIKGYVENMPDGKVHAVLEGDDHQIDKLLELLRQGPVVSQVRDIKVTEIERAGHQGFEVR
What are the official names of this protein?
Acylphosphatase, Acylphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the acylphosphatase family.
Protein: NTRK3_RAT
Sequence: MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEARLDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLHWLYNGQPLRESKIIHMDYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNALGTANQTINGHFLKEPFPESTDFFDFESDASPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPYQKGPFSVSWQQQRLAASAASTLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
What is the function of this protein?
Receptor tyrosine kinase involved in nervous system and probably heart development.  Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation (By similarity).  NTRK3 isoforms containing insertions within the kinase domain can autophosphorylate in response to NTF3/neurotrophin-3, but cannot mediate downstream phenotypic responses (PubMed:8494647, PubMed:8494648).
What are the official names of this protein?
NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.