PharMolix/UniProtQA huggingface dataset:
Protein: RR8_ANGEV
Sequence: MVNDTVANMITSIRNANVIEATTVRIPATNTTKDVGKILLQEGFITNLREHKENTRSFLILTLKYRGRKKKPYITNLKRISKPGLRIYSNHREIPKVLGGMGIVILSTSSGIVTDREARQKQIGGEILCYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: TRAM1_CANLF
Sequence: MAIRKKSTKSPPVLSHEFILQNHADIVSCVAMVFLLGLMFEITAKASIIFVTLQYNVTLPATEEQATESTSLYYYGIKDLATVFFYMLVAIIIHAIIQEYVLDKINRRMHFSKTKHSKFNESGQLSAFYLFSCIWGTFILISENYISDPTILWRAYPHNLMTFQMKFFYIAQLAYWFHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSDEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSAGNFNVLAVRIAVLASICITQAFMMWKFINFQLRRWREHSTFQAPVVKKKPTVTKGRSSRKGTENGVNGTVTSNGADSPRNRKEKSS
What is the function of this protein?
Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel (PubMed:1315422).  Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER.  May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport.  Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane.  Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane.  Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome (By similarity).
What are the official names of this protein?
Translocating chain-associated membrane protein 1, Protein TRAM1.
What is the protein family that this protein belongs to?
Belongs to the TRAM family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: LPXA_ECO7I
Sequence: MIDKSAFVHPTAIVEEGASIGANAHIGPFCIVGPHVEIGEGTVLKSHVVVNGHTKIGRDNEIYQFASIGEVNQDLKYAGEPTRVEIGDRNRIRESVTIHRGTVQGGGLTKVGSDNLLMINAHIAHDCTVGNRCILANNATLAGHVSVDDFAIIGGMTAVHQFCIIGAHVMVGGCSGVAQDVPPYVIAQGNHATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPEVKAFTDFFARSTRGLIR
What is the function of this protein?
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
What are the official names of this protein?
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, UDP-N-acetylglucosamine acyltransferase.
What is the protein family that this protein belongs to?
Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TBC30_MOUSE
Sequence: MRQDKLTGSLRRGGRCLKRQGGGGVGTILSNVLKKRSCISRTAPRLLCTLEPGVDTKLKFTLEPSLGQNGFQQWYDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKNVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRLKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNHTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYGTMGRLTQEMLEQDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATIKPTSVSGRHSKARDSDDENGPDDEDAVASAVGCLGPLSGLLAPELQKYQKQIKEATEEQTLRSNNIAELSPGAINSCRSEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQLHQVYIRADKGPVTSILPSQANSSPVINHLLLGKKMKITNRAAKNAVIHVPGHPGGKISPVPYEDIKTKLNSPWRTHIRVHKKNMPRTKSHLGCGDTVGLIEEQSEGCKASSLGAAEEFPSGRTVTAHSEGSSGDGDGGGSTPRTIEGQSPEPVFGDADVDVAAVQVKLEALELNQRDAAAETEPKVHFPCQRHASELADAPGENQTAIKLLPGSTSKTPIFSPFPSVKPLRKSATARNLGLYGPTERTPNVHFPQMSRGFNKSGIGNSSTKKR
What is the function of this protein?
GTPase-activating protein (GAP) with broad specificity.  Acts as a GAP for RAB3A.  Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro (By similarity).
What are the official names of this protein?
TBC1 domain family member 30.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: Y4254_TRIV2
Sequence: MRSIMVQSAKTDSVNQQTIEGLKLQIKKLNSKAGQLKMDLHDLAEGLPIDYQNLTALAAETYEIYRHLDELKSQLKSLEKNHDMGY
What are the official names of this protein?
UPF0437 protein Ava_4254.
What is the protein family that this protein belongs to?
Belongs to the UPF0437 family.
Protein: F27D1_HUMAN
Sequence: MLEKRLLRMGMRLQLLRDRRISSRGPGLHRAKADPQQQKRLTTGLMTQAETQKEAQQRQAAMRKTALWHTGHLQPKTHTHTGMHTQTHRERERNTQRLRDRERRENGRHTHRHTHTLTHTHTHRDTHTASYRRGIETHTTRQPLRLRGSAHDENDPRVREQPRGTQADLSSRSRMAARLLGRLTPTNTVRAGLRLGSRAASPDPAWGFLIVVGPL
What are the official names of this protein?
Protein FAM27D1.
What is the protein family that this protein belongs to?
Belongs to the FAM27 family.
Protein: UBQL1_MOUSE
Sequence: MAESAESGGPPGAQDSAADGGPAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHIDQLVLIFAGKILKDQDTLSQHGIHDGLTVHLVIKTQNRPQDNSAQQTNAPGSTVTSSPAPDSNPTSGSAANSSFGVGGLGGLAGLSSLGLNTTNFSELQSQMQRQLLSNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFASLVSSSSSAEGTQPSRTENRDPLPNPWAPQTSQSSPASGTTGSTTNTMSTSGGTATSTPAGQSTSGPSLVPGAGASMFNTPGMQSLLQQITENPQLMQNMLSAPYMRSMLQSLSQNPDLAAQMMLNNPLFAGNPQLQEQMRQQLPTFLQQMQNPDTLSAMSNPRAMQALLQIQQGLQTLATEAPGLIPGFTPGLAAGNSGGSSGTNAPSTAPSEDTNPQGGTAEPGHQQFIQQMLQALAGVNPQLQSPEVRFQQQLEQLSAMGFLNREANLQALIATGGDINAAIERLLGSQPS
What is the function of this protein?
Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress.
What are the official names of this protein?
Ubiquilin-1, Protein linking IAP with cytoskeleton 1, PLIC-1.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Endoplasmic reticulum. Cytoplasmic vesicle, autophagosome. Cell membrane. Note=Detected in neuronal processes and at synapses. Recruited to the ER during ER-associated protein degradation (ERAD). Colocalizes with PSEN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes. Colocalizes with ORAI1 and TICAM1 in the autophagosome. Colocalizes with EPS15 and HGS in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and with EPS15 also in aggresomes.
Protein: WLS_CAEEL
Sequence: MAGGAVIENLSNRKLFVIFAGLLVIQIMFFLIGAWYAPSPSSYMEFEMITCRDETKGLSGEWIHRDNCQQISELSEYTPSSFDLREIVFIAKMPHTRDGIELEYSPWFQFLLGVLHVDVEYSEHFKYVAHAPLELEVRMGYRDKESKKNEWKELVTSNVTRILECTIAEDEKKAGGTYDCDMLDLFELGSSSYPFYLINIRIPINQQACQFDNKSANCQIGKLTGLRLIEIHQNGGFTLVWLWTKTFMTPVVAICLWWYYNRINQLARNPLLLERAILLLGLSLVILDFPIEWISLTYRIPFLLLISDLRQGLFYTVLFSFWLIFAGEHLIDDNTRNNLKSYRFNLSFIITASLGLLIYDLIERGIQLYDPFYSVWSSPTGSQIAYFAIFISAISTVAYFIFLFFKIARVWSTIKSKRSAQIYQTSENRRLKVEGVIYRFKFLMLFTLLCSAFTIAAYFMKQYGEAQLHGDEARDGFLTGSTSAFFTGAFGMCNIYVLLLLAMYAPSHKHYRGASQLIDENDDDEIMEDPSNQHTESNAMTTFLKPSTD
What is the function of this protein?
Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20 (PubMed:18160346, PubMed:18160347, PubMed:21076391).  Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function (PubMed:18160346, PubMed:18160347, PubMed:21076391).  Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex (PubMed:21076391).  Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:9288749, PubMed:16678095).  Functions during vulval development, playing a role in vulval precursor cell fate specification (PubMed:11063687, PubMed:18077322).  During development, specifically regulates the migration of HSN neurons, the left Q neuroblast (QL) and its descendants and the distal tip cells of the gonads (PubMed:8898225, PubMed:10388818, PubMed:11063687, PubMed:18160346, PubMed:18160347).  Positioning of Q neuroblasts may be both dependent and independent of hox gene mab-5 (PubMed:8898225).  Involved in establishing ALM and PLM neuronal cell polarity (PubMed:18160346).
What are the official names of this protein?
Protein wntless homolog, Abnormal cell migration protein 14.
What is the protein family that this protein belongs to?
Belongs to the wntless family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Note=Traffics between endosomal cell membrane and the Golgi apparatus membrane and the cell membrane to mediate wnt/egl-20 secretion (PubMed:18160347, PubMed:21076391). Co-localizes with snx-3 on intracellular punctae and early endosomes to facilitate recycling and wnt/egl-20 secretion (PubMed:21076391). Localizes to the basolateral cell membrane of intestine cells, but not the apical cell membrane (PubMed:26115433).
Protein: GLND_CUPPJ
Sequence: MPTNLPALPMDTTPELLLAARVRDQLKADKQALFADFDLSSHVGTLVTRLRRAVDAALAEAWRGLDMPADAALVAVGGYGRGELFPYSDVDVLLLLRAEPDADTVSRLERFIGMCWDLGLEIGSSVRTVEDCIREARADITIQTSLLEARLLTGNRKLFEALRTQHQADLDPAAFFQAKLLEMRQRHAKYQDTPYALEPNCKESPGGLRDLQVILWMTKAAGLGDSWKELFERGLLTQREAQELSRNERLLKTIRARLHLVAGRRQDVLVFDLQTALAESFGYRQNANKRASEQLMRRYFWAAKAVTQLNSVLLLNIEALLFPSESQVTRVINERFVERQGMLEITSDSLYEDDPHAILETFLLYERTPGIKGLSPRTLRGLYNARTVMDARWRSDPENRRLFLAILQEPQGITHALRLMNQTSVLGRYLINFRRIVGQMQHDLFHVYTVDQHILMVVRNMRRFAIVEHTHEFPFCSQLMASFDKPWVLSVAALFHDIAKGRGGDHSKLGTVDARRFCKQHGIGREDADLICWLVEHHLTMSHVAQKQDLTDPDVVHAFARVVGDERHLTALYLLTVADVRGTSPKVWNAWKGKLLEDLYRITLRVLGGARVDPHSIWAQRQEETISQLRLKAFDPELGKPLWAQLDVAFFLRHDSRDIAWLTRHLFNKVDSPVPVVKARISPAGEGLQVAVYVKDQPDLFARICGYFERKAFSIQDAKIHTTRHGYALDTFQVTDPGLADDGGNYRDILALVEHELGDRLQQQAALPEPSQGRLSRQSRSFPIKPRVDLRPDERGQYYLLSLSANDRTGLLYAITRVLAKHRVSVHTARINTLGERVEDVFLVDGSRLAADNRLQIQLEQDLLAALEI
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: HISZ_BURCH
Sequence: MSTWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLSGRTLGLRADITPQVARIDAHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLGHAGVLAALLARDAQAAERGESLYDALSGKDVPLLNELTDDLGADTRAALRALPNLYGDASVLAEARTRLPVLPEITRALDDLAQLASQAKGVEVAIDLADLRGYAYHSGAMFSAYIDGVPNAIARGGRYDHVGQAYGRSRPATGFSLDLRELARISPVEARGTAILAPWAQDDALGAAVAALRDAGEVVIQALPGHDHVLDEFACDRSLVERNGAWVVEPR
What is the function of this protein?
Required for the first step of histidine biosynthesis.  May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
What are the official names of this protein?
ATP phosphoribosyltransferase regulatory subunit.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATC4_YEAST
Sequence: MSSPSKPTSPFVDDIEHESGSASNGLSSMSPFDDSFQFEKPSSAHGNIEVAKTGGSVLKRQSKPMKDISTPDLSKVTFDGIDDYSNDNDINDDDELNGKKTEIHEHENEVDDDLHSFQATPMPNTGGFEDVELDNNEGSNNDSQADHKLKRVRFGTRRNKSGRIDINRSKTLKWAKKNFHNAIDEFSTKEDSLENSALQNRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNILFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIEDSRRTVLDLEVNNTRTHILSGVKNENVAVDNVSLWRRFKKANTRALIKIFEYFSENLTAAGREKKLQKKREELRRKRNSRSFGPRGSLDSIGSYRMSADFGRPSLDYENLNQTMSQANRYNDGENLVDRTLQPNPECRFAKDYWKNVKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSLKCSKIIKSSRDITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINAGVTPTKKSRISRELNFSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLVEPNKDDPKKLDIKAQSPDESALVSTARQLGYSFVGSSKSGLIVEIQGVQKEFQVLNVLEFNSSRKRMSCIIKIPGSTPKDEPKALLICKGADSVIYSRLDRTQNDATLLEKTALHLEEYATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCKAVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAIGQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYGIYNNFDGSYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRKEWNQTKFLWYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRWDWFCGLFICLSLAVFYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRKIFYPKDIEIVREMWLRGDFDLYPQGYDPTDPSRPRINEIRPLTDFKEPISLDTHFDGVSHSQETIVTEEIPMSILNGEQGSRKGYRVSTTLERRDQLSPVTTTNNLPRRSMASARGNKLRTSLDRTREEMLANHQLDTRYSVERARASLDLPGINHAETLLSQRSRDR
What is the function of this protein?
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.  Required for protein transport from Golgi to vacuoles.
What are the official names of this protein?
Phospholipid-transporting ATPase DNF2, Flippase DNF2.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ST2A1_RAT
Sequence: MPDYTWFEGIPFHAFGISKETLQNVCNKFVVKDEDLILLAYPKSGTNWLIEIVCLIQTKGDPKWIQSVTIWDRSPWIETDLGYDMLIKKKGPRLITSHLPMHLFSKSLFSSKAKVIYLVRNPRDVLVSGYYFWGNSTLAKKPDSLGTYVEWFLKGNVLYGSWFEHIRAWLSMREWDNFLLLYYEDMKKDTMGTIKKICDFLGKKLEPDELDLVLKYSSFQVMKENDMSNYSLLMKKSIFTGIGLMRKGTVGDWKNHFTVSQAEAFDKVFQEKMAGFPPGMFPWE
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (By similarity).  Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:7854148).  Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites.  Plays an important role in maintening steroid and lipid homeostasis.  Plays a key role in bile acid metabolism (By similarity).  In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (PubMed:7854148).
What are the official names of this protein?
Sulfotransferase 2A1, ST2A1, Bile salt sulfotransferase, Hydroxysteroid sulfotransferase, ST, ST-20.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TSAD_RUEPO
Sequence: MAQTLTILGLESSCDDTAAAVVRQTEGQAAEILSSVVHGQADLHSAYGGVVPEIAARAHAEKLDICVRQALTEAGVSLTDLDAVAVTAGPGLIGGVMSGVMCAKGIAAATGLPLIGVNHLAGHALTPRLTDQIAYPYLMLLVSGGHCQYLIAHGPEQFSRLGGTIDDAPGEAFDKTARLLGLPQPGGPSVEGEARQGDPKRFRFPRPLLDRPDCDLSFSGLKTALMRMRDQLVGEKGGLTRQDRADLCAGFQAAVVDTLAEKTRRALTLYLDEAPAEPVVAVAGGVAANAAIRAALETVCAEAGARFTAPPLRLCTDNAAMIAYAGLERFRSGARDGLDLTARPRWPLDQSSPAMLGSGKKGAKA
What is the function of this protein?
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB.  TsaD likely plays a direct catalytic role in this reaction.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD, tRNA threonylcarbamoyladenosine biosynthesis protein TsaD.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNMA1_BACFR
Sequence: MMEKNKRVLLGMSGGTDSSVAAMLLLEAGYEVTGVTFRFYEFNGSTEYLEDARALAARLGIGHITYDARKVFQEQIIDYFIDEYMSGHTPVPCTLCNNQLKWPLLAKIADEMGIFYLATGHYVRKQWVDGNYYIAPAEDVDKDQSFFLWGLRQEILQRMLLPMGGMTKSEARAYAAGRGFEKVSKKKDSIGVCFCPLDYRSFLKKCLCDESGDKNRNIYRKVERGRFLDESGNFIAWHEGYPFYTIGQRRGLGIQLNRAVFVKEIHPETNEVVLASLKSLEKSEMWLKDWNIVDESRLLGCDDVIVKIRYRKQENHCSVTITPEGLLHIRLHEPLSAIAEGQAAAFYKDGLLLGGGIITMSDQR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA 1.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_CERS1
Sequence: MKLFVGLGNPGARYAGNRHNIGYMAVEAIAADHGFGPWRARFQGLTSEGRLGSEQVLLLKPETFMNLSGQSVGEAMRFYKLTPADVIVFHDELDLAPGKLRLKQGGGHAGHNGLRSIHAHVGEAYGRVRLGIGHPGHKDAVAPYVLSDFAKADQDWLADLLRGIADGAEALARGDGAKFQNAVALRMQPPKPEKPKPAAKAPEAQAPEAAPDERSALQKLADRFR
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FER5_AQUAE
Sequence: MPKVIVANINAEFEGIENETIMQILYRNGIEIDSACGGHGQCTSCKVLIISGSENLYPAEFEEKDTLEENGMDPETERLSCQAKLNGKGDVVIYLP
What is the function of this protein?
May be involved in the assembly of iron-sulfur clusters (Isc-Fd).
What are the official names of this protein?
2Fe-2S ferredoxin-5, Fd5.
What is the protein family that this protein belongs to?
Belongs to the adrenodoxin/putidaredoxin family.
Protein: T126B_MOUSE
Sequence: MAASQRPSWSESKVAGVVQEGNREAPQDIKMALYKHGQLIPSLGDAKFRSPIISEIIEKKFEHYRNDKTLNIHGTLVFGTSSSLSGIMANLVFRNSFKVKYEALKTYASLTTLPVLATIVSYKLFVTDALQSGDISKESCVLRSALIGMACGVSYPSALAFYKNGRLAVKYQTVPLPPKGRVMLHWLLLCQTGMKAMAIPLFFQIVMGAFTGLHHYNICEKPRARLVPDD
What is the function of this protein?
As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.  Participates in constructing the membrane arm of complex I.
What are the official names of this protein?
Complex I assembly factor TMEM126B, mitochondrial, Transmembrane protein 126B.
What is the protein family that this protein belongs to?
Belongs to the TMEM126 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Multi-pass membrane protein.
Protein: PRMA_BACC1
Sequence: MKWSEISIHTKEEAVEAVSHILHEAGASGVAIEDPAELTKEREQQYGEIYALNPDEYPAEGVLIKAYFPQTDSLHETIAGVKSSIDVLPSYDIEIGTGNITVNEVNEEDWATAWKKYYHPVQISDTFTIVPTWEEYTPSSPEEKIIELDPGMAFGTGTHPTTTMCIRALEKTVQQGDTIIDVGTGSGVLSIAAAKLGASSVQAYDLDPVAVESAEMNVRLNKTDDIVSVGQNSLLEGIEGPVDLIVANLLAEIILLFPEDAARVVKSGGLFITSGIIAAKEKVISEALEKAGFTIEEVLRMEDWVAIIARNA
What is the function of this protein?
Methylates ribosomal protein L11.
What are the official names of this protein?
Ribosomal protein L11 methyltransferase, L11 Mtase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. PrmA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISPH_BURP2
Sequence: MRVILAQPRGFCAGVVRAIEIVERALQQNGAPVYVRHEIVHNRHVVENLRNKGARFVEELDEVPHGAVAIFSAHGVAQTVEQDAQARGLDVLDATCPLVTKVHVQGRQYVAAGRRLILIGHAGHPEVEGTIGQIPAEVILVQSEAEVDTLTLPADTPVAYVTQTTLSVDDTRGIIEALQRRFTDIVGPDTRDICYATQNRQAAVRELSEQVDVLLVVGATNSSNSNRLREIGTESGVPSYLVADGSEVRAEWFANARTVGLTAGASAPEEMVEDVIAALRALGPLEVATMSGREEKVEFKLPAKLTQAVAREV
What is the function of this protein?
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).  Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
What are the official names of this protein?
4-hydroxy-3-methylbut-2-enyl diphosphate reductase, HMBPP reductase.
What is the protein family that this protein belongs to?
Belongs to the IspH family.
Protein: RSSA_SPAAU
Sequence: MSGGLDVLQMKEEDVLKFLAAGTHLGGTNLDFQMDQYVYKRKSDGVYIINLKKTWEKLLLAARAIVAIENPADVCVISSRNTGQRAVLKFASATGATTFHGRFTPGTFTNQIQAAFREPRLLIVTDPRADHQPLTEASYVNIPTIALCNTDSPLRYVDIAIPCNNKGHHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVGKEEFQGEWSAPAAEFTQPEVADWSEGVAVPSVPIQQFPAGTPAPAPAVKTEDWSTQPATEDWSTAPTAQASDWGGATSDWS
What is the function of this protein?
Required for the assembly and/or stability of the 40S ribosomal subunit.  Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.  Also functions as a cell surface receptor for laminin.  Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways.  May play a role in cell fate determination and tissue morphogenesis.
What are the official names of this protein?
40S ribosomal protein SA, 37 kDa laminin receptor precursor, 37LRP, 37/67 kDa laminin receptor, LRP/LR, 67 kDa laminin receptor, 67LR, Laminin receptor 1, LamR, Laminin-binding protein precursor p40, LBP/p40.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
What are the subcellular locations of this protein?
Cell membrane. Cytoplasm. Nucleus. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus.
Protein: T184B_MOUSE
Sequence: MTVRGAALAPDPASPTTTTASPSVSATPEGSPTAMEHPVFLMTTAAQAISGFFVWTALLITCHQIYMHLRCYSRPNEQRHIVRILFIVPIYAFDSWLSLLFFTNDQYYVYFGTVRDCYEAFVIYNFLSLCYEYLGGESAIMSEIRGKAIESSCMYGTCCLWGKTYSIGFLRFCKQATLQFCVVKPLMAVSTVILQAFGKYRDGDFDVTSGYLYVTIIYNISVSLALYALFLFYFATRELLSPYSPVLKFFMVKSVIFLSFWQGMLLAILEKCGAIPKINSARVSVGEGTVAAGYQDFIICVEMFFAALALRHAFTYKVYADKRLDAQGRCAPMKSISSSLKETMNPHDIVQDAIHNFSPAYQQYTQQSTLEPGPTWRGGTHSLSRSHSLSGARDNEKTLLLSSDDEF
What is the function of this protein?
May activate the MAP kinase signaling pathway.
What are the official names of this protein?
Transmembrane protein 184B.
What is the protein family that this protein belongs to?
Belongs to the TMEM184 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: RL15_TREPS
Sequence: MADFHLIAPKGANRARRIVGRGSSSGRGTTSGRGTKGQQARAGHKAYVGFEGGQMPLYRRVPRRGFSNCAFKKEYAVVNVGALEFVYAPGETVNRQTLIEKGLVKGRVPFIKILADGELTKSIVVRVDRVSARAQEKIQQAGGSVECIEAQER
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L15.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL15 family.