PharMolix/UniProtQA huggingface dataset:
Protein: MDR_LEITA
Sequence: MVDNGHVTIAMADLGTVVEIAQVRCQQEAQRKFAEQLDELWGGEPAYTPTVEDQASWFQQLYYGWIGDYIYKAAAGNITEADLPPPTRSTRTYHIGRKLSRQAHADIDASRRWQGYIGCEVVYKSEAEAKGVLRWVGHLQQSDYPRSLVAGVEWRMPPRHRRLAVLGSAAALHNGVVHGERLFWPHEDNYLCSCEPVEQLYVKSKYNLIPPRPPPSPDLLRTLFKVHWYHVWAQILPKLLSDVTALMLPVLLEYFVKYLNADNATWGWGLGLALTIFLTNVIQSCSAHKYDHISIRTAALFETSSMALLFEKCFTVSRRSLQRPDMSVGRIMNMVGNDVDNIGSLNWYVMYFWSAPLQLVLCLLLLIRLVGWLRVPGMAVLFVTLPLQAVISKHVQDVSERMASVVDLRIKRTNELLSGVRIVKFMGWEPVFLARIQDARSRELRCLRDVHVANVFFMFVNDATPTLVIAVVFILYHVSGKVLKPEVVFPTIALLNTMRVSFFMIPIIISSILQCFVSAKRVTAFIECPDTHSQVQDIASIDVPDAAAIFKGASIHTYLPVKLPRCKSRLTAMQRSTLWFRRRGVPETEWYEVDSPDASASSLAVHSTTVHMGSTQTVITDSDGAAGEDEKGEVEEGDREYYQLVSKELLRNVSLTIPKGKLTMVIGSTGSGKSTLLGALMGEYSVESGELWAERSIAYVPQQAWIMNATLRGNILFFDEERAEDLQDVIRCCQLEADLAQFCGGLDTEIGEMGVNLSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVGQRIVQDVILGRLRGKTRVLATHQIHLLPLADYIVVLQHGSIVFAGDFAAFSATALEETLRGELKGSKDVESCSSDVDTESATAETAPYVAKAKGLNAEQETSLAGGEDPLRSDVEAGRLMTTEEKATGKVPWSTYVAYLKSCGGLEAWGCLLATFALTECVTAASSVWLSIWSTGSLMWSADTYLYVYLFIVFLEIFGSPLRFFLCYYLIRIGSRNMHRDLLESIGVARMSFFDTTPVGRVLNRFTKDMSILDNTLNDGYLYLLEYFFSMCSTVIIMVVVQPFVLVAIVPCVYSYYKLMQVYNASNRETRRIKSIAHSPVFTLLEESLQGQRTIATYGKLHLVLQEALGRLDVVYSALYMQNVSNRWLGVRLEFLSCVVTFMVAFIGVIGKMEGASSQNIGLISLSLTMSMTLTETLNWLVRQVAMVEANMNSVERVLHYTQEVEHEHVPEMGELVAQLVRSESGRGANVTETVVIESAGAASSALHPVQAGSLVLEGVQMRYREGLPLVLRGVSFQIAPREKVGIVGRTGSGKSTLLLTFMRMVEVCGGVIHVNGREMSAYGLRDVRRHFSMIPQDPVLFDGTVRQNVDPFLEASSAEVWAALELVGLRERVASESEGIDSRVLEGGSNYSVGQRQLMCMARALLKRGSGFILMDEATANIDPALDRQIQATVMSAFSAYTVITIAHRLHTVAQYDKIIVMDHGVVAEMGSPRELVMNHQSMFHSMVESLGSRGSKDFYELLMGRRIVQPAVLSD
What are the official names of this protein?
Multidrug resistance protein, P-glycoprotein.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: TAT_HV1BN
Sequence: APEDSQSHQVSLSKQPASQAGGDPTGPKESKKKVESETETDPVP
What is the function of this protein?
Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR.  Neurons are rarely infected, but they internalize Tat via their LDLR.  Endosomal low pH allows Tat to cross the endosome membrane to enter the cytosol and eventually further translocate into the nucleus, thereby inducing severe cell dysfunctions ranging from cell activation to cell death.  Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression.  Tat seems to inhibit the HAT activity of KAT5/Tip60 and TAF1, and consequently modify the expression of specific cellular genes.  Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines (such as IL10) or cytokine receptors.  May be involved in the derepression of host interleukin IL2 expression.  Mediates the activation of cyclin-dependent kinases and dysregulation of microtubule network.  Tat plays a role in T-cell and neurons apoptosis.  Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS.  Host extracellular matrix metalloproteinase MMP1 cleaves Tat and decreases Tat's mediated neurotoxicity.  Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways.  In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.  Binds to KDR/VEGFR-2.  All these Tat-mediated effects enhance angiogenesis in Kaposi's sarcoma lesions (By similarity).
What are the official names of this protein?
Protein Tat, Transactivating regulatory protein.
What is the protein family that this protein belongs to?
Belongs to the lentiviruses Tat family.
What are the subcellular locations of this protein?
Host nucleus, host nucleolus. Host cytoplasm. Secreted. Note=Probably localizes to both nuclear and nucleolar compartments. Nuclear localization is mediated through the interaction of the nuclear localization signal with importin KPNB1. Secretion occurs through a Golgi-independent pathway. Tat is released from infected cells to the extracellular space where it remains associated to the cell membrane, or is secreted into the cerebrospinal fluid and sera. Extracellular Tat can be endocytosed by surrounding uninfected cells via binding to several receptors depending on the cell type (By similarity).
Protein: FMT_YERPA
Sequence: MSDSLRIIFAGTPDFAARHLGALLSSQHKIVGVFTQPDRPAGRGNKLTPSPVKILAEHHGIPVFQPKSLRPEENQHLVADLNADIMVVVAYGLILPAAVLAMPRLGCINVHGSLLPRWRGAAPIQRSVWAGDEKTGITIMQMDIGLDTGAMLHKIECAIQPEDTSATLYDKLAQLGPQGLLITLQQLAAGTALAEVQNETQATYAEKLSKEEAKLDWTLSATQLERCIRAFNPWPVSYFIVDEQPIKVWQAQVLPAGEDAEPGTIIHADKHGIQVATADGVLNITQLQPAGKKAMSAADLLNSRREWFIPGSQLV
What is the function of this protein?
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet).  The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
What are the official names of this protein?
Methionyl-tRNA formyltransferase.
What is the protein family that this protein belongs to?
Belongs to the Fmt family.
Protein: TSN15_MOUSE
Sequence: MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGGLVLSVGIYAEAERQKYKTLESAFLAPAIILILLGVVMFIVSFIGVLASLRDNLCLLQSFMYILGICLVMELIGGIVALIFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCSAPGPLACGVPYTCCIRNTTDVVNTMCGYKTIDKERLNAQNIIHVRGCTNAVLIWFMDNYTIMAGLLLGILLPQFLGVLLTLLYITRVEDIILEHSVTDGLLGPGAKSRTDTAGTGCCLCYPD
What is the function of this protein?
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:23035126, PubMed:26668317).  Promotes ADAM10-mediated cleavage of (CDH2) (PubMed:26668317).  Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity).
What are the official names of this protein?
Tetraspanin-15, Tspan-15, Transmembrane 4 superfamily member 15.
What is the protein family that this protein belongs to?
Belongs to the tetraspanin (TM4SF) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Late endosome membrane.
Protein: ATP6_RHILW
Sequence: MSNDPTHQFQIFKIVPIEIGGIDFSFTNASLFMAASAAVAVGFLYFATSNRAIVPGRSQSVAEMSYEFIANMLKEGAGKQGMKFFPLVFSLFMFVLTANLLGMFPYFFTITSQIIVTFALAILVIGTVLVYGFYKHGFHFLNVFVPSGVPGILLPLVVSIEIISFLSRPISLSVRLFANMLAGHITLKVFAGFVASLGALGAVGVGGAVLPLIMTVALTGLEFLVAFLQAYVFAVLTCMYLNDAIHPGGH
What is the function of this protein?
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
What are the official names of this protein?
ATP synthase subunit a, ATP synthase F0 sector subunit a, F-ATPase subunit 6.
What is the protein family that this protein belongs to?
Belongs to the ATPase A chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: CH60_ACIBT
Sequence: MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEISLKDKFENMGAQLVREVSSKTNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVKTVVENIRSIAKPADDFKAIEQVGSISANSDTTVGKLIAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELISVLEAVAKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQATLQDLGTAHKITVSKENTVIVDGAGDAAAIAERVQQIRAQIEESTSEYDREKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALVRAVNALEGLKGANEDQTAGINILRRAIEAPLRQIVANAGDEPSVVINAVKNGEGNFGYNAATGEYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTECMITDIPEDKPAAPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OST48_CAEEL
Sequence: MRWLPGLLLIASIGFHQSLADRVLVLGETAAVKDTHSVFLNSVKERGHELTVRAADDSQLALFKHGQLIFDHLFILAPGVQVFGGSLSPSEISKFVDAGGNVLVAAGSNIGDALREIAAEHGFEFEEAGTSVIDHHNYDQTLDSGDHTTLVVGKDQLISAELIVGNSAKLHPVLFKGIGLVAGKTNNLALSIVRASGTAYSYDPKAVRATNPSIAGSRTLLVGGLQSRNNARIVFTGSSELFSNTFFSAKTNSVNPSVQGAQSGNADFATAITRWVMKESGVLRVKTVNHHKKGETVPPVEGYFITEDVVYTIEIEELKNGKWVPFQGKDVQLEFVRIDPFVRATLKNSNGRLSVAFKLPDVLGVFKFLVDYRRVGYTHLYDVQQVSVRPLWHTQYERFIRSAYPYYASSFSMMAGLVLFSIVYLYHKDTPVKGAKVLDSEKKKN
What is the function of this protein?
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation.  N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  All subunits are required for a maximal enzyme activity (By similarity).  Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity).  Required for normal lifespan (PubMed:36173858).
What are the official names of this protein?
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Oligosaccharyl transferase 48 kDa subunit, Oligosaccharyl transferase beta subunit 1.
What is the protein family that this protein belongs to?
Belongs to the DDOST 48 kDa subunit family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: KAE1_COCIM
Sequence: MIAIGLEGSANKLGVGIILHPDNGGEPRVLANIRHTYVSPPGEGFLPKDTAKHHRKWVVSLVKAALKEAEIGVSDVDCICYTKGPGMGPPLQSVALAARTLSLLWGKQLVGVNHCVGHIEMGRYITGAQNPIVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLHISNDPAPGYNIEQLAKKGKRLVELPYTVKGMDCSFSGILAAIDALAAAYGLSGDQQAKENIGLTEDALKLKVDSVDKYNNEGGIPTREDLCFSLQETVFSMLVEITERAMAHVGSREVLIVGGVGCNERLQEMMGIMARDRGGNVFATDERFCIDNGIMIAQAGILAYKTGFTTKLEDSTCTQRFRTDEVFVQWRDD
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.  KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.  The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation.  The complex is required for efficient recruitment of transcriptional coactivators.
What are the official names of this protein?
tRNA N6-adenosine threonylcarbamoyltransferase, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1, tRNA threonylcarbamoyladenosine biosynthesis protein KAE1.
What is the protein family that this protein belongs to?
Belongs to the KAE1 / TsaD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SYS_SALPB
Sequence: MLDPNLLRNEPDAVAEKLARRGFKLDVDKLRALEERRKVLQVNTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDTLLAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEIRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNHDTLYGTGQLPKFAGDLFHTRPLEEEADSSNYALIPTAEVPLTNLVRDEIIDEDQLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWVPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FOLD2_GEOSL
Sequence: MATIIDGKAIAEKIRADLAAQVKELQSRGITPGLATVLVGSDPASEVYVRMKGDACNKLGMHSVKITRPAETTEEELLALINELNNDPAIHGILVQLPLPPQINADRVLEAISPAKDVDGFHPYNVGRLVTGKPTFQPCTPYGVMVMLQEAGVDLAGKEVVVVGRSNIVGKPVALMCLQRNATVTICHSKTRDLPGRVRAADVVIAAVGVPEMIKGDWIKEGAVVIDVGVNRVGEKKLVGDVEFAAAAERASAITPVPGGVGPMTITMLLHNTLEAAKMAGSGNR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD 2.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: IFT57_CHLRE
Sequence: MSSKRGGRSSLAKAPEEAVNGEAFAPEASPPPPGDDGDAGGEDGGAPAPPPPPATKGGPVAVGRSLEIQTTPDVCMEMLADKLKLLNYEADFCRKKKPYRKPLSRLYFAVPLANSSEQFFYFTSLATWLLGLAGVELPAPKEFDDPNLTCQNILGAVKKLGFAPPSYHPTKLTVGNGKEVVGVLDGLVDFVLERRHHKYSRPAYGNDGQPEEGVQLDDEAEAAAMEGADELAMPAQNQADDDEEEEGVYVDPGRGDAAGPGTGASAAMDAEKAVLVSKVDPTLWKIELERVAPKLRITIAADSKDWRSHLDEAHQHKEVISKAWPDSKTSLERLRADLNGTLEKLQTREKFLNEQFESLMQQYRAARTTFTDVQETYNRKTEAVADRNQEMHRIGETLEEVKAMMDEKGSNIADATPVARIKTAIKQLNKELHDMEVRIGVVSHTLLQLSLRNKRLLQAQAALSDEEED
What is the function of this protein?
Required for the maintenance and formation of cilia.
What are the official names of this protein?
Intraflagellar transport protein 57.
What is the protein family that this protein belongs to?
Belongs to the IFT57 family.
What are the subcellular locations of this protein?
Cell projection, cilium.
Protein: CSPL1_GINBI
Sequence: MNASHPAVHPVGVPPAVAGQLPPRMRMKEIQGMPGTIGGLLLRLGQFCFALVAFSIMVSIENFSTVTAFCYLVAATVLQCLWSLALAIIDGYALLVKRSLRNSLLVSLLVVGDGVTATLTFAAACASAGITVLIGNDLRQCKENHCARYETATALAFLSWFMVSLSFILTFWLLATR
What are the official names of this protein?
CASP-like protein 5A2, GbCASPL5A2.
What is the protein family that this protein belongs to?
Belongs to the Casparian strip membrane proteins (CASP) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y2295_STAES
Sequence: MDKHFVYIVKCNDGSLYTGYAKDVNARVIKHNNGKGAKYTKIRRPVELVYQETYTTKSEALKREYEIKTYTRQQKLKMIQEG
What are the official names of this protein?
UPF0213 protein SE_2295.
What is the protein family that this protein belongs to?
Belongs to the UPF0213 family.
Protein: NDK_PASMU
Sequence: MAVERTLSLIKPDAVKRHLIGAILSRFEQAGFRVVAAKMLHLTQAQAEGFYAEHQDKAFFPELVAYMISAPVLALVLEKENAVKDYRTLIGATNPAVAAEGTIRRDFAIDGRHNSVHGSDSLDSAKREIAYFFVESEIF
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SWM2_YEAS7
Sequence: MIDLYNYSNLEGLLDGLTDLNRIPKEYSAVLEPYFQNIARNAHLKSRALKICRSNFHKWNEEGAKTVNPEIIRRCLNLWYVLKGKEYKKLKDPPPADNIIKDEIDVSYVKNLNEVRLEFDEFGKLISNPLENLILEEVEVNDFIQE
What are the official names of this protein?
Nucleolar protein SWM2, Synthetic With MUD2-delta protein 2.
What is the protein family that this protein belongs to?
Belongs to the SWM2 family.
What are the subcellular locations of this protein?
Nucleus, nucleolus.
Protein: ID1_RAT
Sequence: MKVASSSAAATAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGTRLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVATAGGRGLPVRAPLSTLNGEISALAAEVRSESEYYIILLWETKATGGGCPPYFSGA
What is the function of this protein?
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity.  Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.  Inhibits skeletal muscle and cardiac myocyte differentiation.  Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity).
What are the official names of this protein?
DNA-binding protein inhibitor ID-1, Inhibitor of DNA binding 1, Inhibitor of differentiation 1.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: Y382_RHIME
Sequence: MQIPFLHKRKRGKKPSAAAAAARAVDKARYDGTLIARGLTKSYRSRRVVNGVSLVVRRGEAVGLLGPNGAGKTTCFYMITGLVPVDEGSIEINGNDVTTMPMYRRARLGVGYLPQEASIFRGLTVEDNIRAVLEVHDENVDRRESKLNDLLGEFSITHLRKSPAIALSGGERRRLEIARALATDPTFMLLDEPFAGVDPISVADIQALVRHLTSRGIGVLITDHNVRETLGLIDRAYIIHAGEVLTHGRANDIVTNPDVRRLYLGDNFSL
What are the official names of this protein?
Uncharacterized ABC transporter ATP-binding protein R00382.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
Protein: EX7S_RHIE6
Sequence: MTDSAKPEVAGLSFEKAVAELESIVARLERGDVALDESIEIYERGEALKKHCETLLSAAENRIEKIRLDRAGKPQGVEPLDGA
What is the function of this protein?
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
What are the official names of this protein?
Exodeoxyribonuclease 7 small subunit, Exodeoxyribonuclease VII small subunit, Exonuclease VII small subunit.
What is the protein family that this protein belongs to?
Belongs to the XseB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IMPE2_DROME
Sequence: MKPVALILVFLAISQARVLNLPKEAIDIPVAIVEDKEPPVALSLVKEEVKAEEVKPEEVKPIAQEEKAKDLKEEVKPEIKPEIKEQPKPDIKDEIKEDLKADIKEELKEKIEEQINELPNAKPLELKEKSLEAEEKPQEIKEEVQQPEIKKEATEIKEEPAQNILKSLPAEETVVVPAEELSPNPVEQEQSENQDAAHPQVRQATQATPTQQSTTQGNFVQQLIQNSPIGQFLNQFQPQPAAAAAPAAAQVQADDAAAAAPATPAPTVPGFLNPQAAITSAQQAVQNAAQSAVNATTQAFQGIQQFASNLGNQFQNTLSSLTGQQQQAVSTTPRPPGPIQQFVNNVFGGNNNATAAAPPAQQSGNPLQGIINFLGGNRPQNAPAAAPATQATEKPAVDDKIDPANDEVGEFVPESDNELRASGENIDDSFEDAGVPSNEVIVVNDDAGEEGNAVQNHPVATDAVAL
What is the function of this protein?
Probably has an essential role in embryogenesis, induces morphogenesis of imaginal disks, and may participate in multimolecular aggregates.
What are the official names of this protein?
20-hydroxyecdysone protein, 20-HE.
What are the subcellular locations of this protein?
Secreted. Note=Secreted from the apical cell surface.
Protein: NTPTH_METBF
Sequence: MLRIAVTGIPGIGKSTVVAKAAEKLADQPGFKIGGIQTAEIRKEGQREGFSIMDLATGKTGVLGSIRESGPRVGKYHVNLEDLEKIGANALRSAMDCDLIVIDEVGTMELKSEAFVSAVKVVLESDKPVLAVLHRSSSHQLVQRMRREFEVLVVNEKNRDGLPGKIANRFREMR
What is the function of this protein?
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP.  May hydrolyze nucleoside diphosphates with lower efficiency.
What are the official names of this protein?
Nucleoside-triphosphatase THEP1, NTPase THEP1, Nucleoside triphosphate phosphohydrolase.
What is the protein family that this protein belongs to?
Belongs to the THEP1 NTPase family.
Protein: MRAY_SALTO
Sequence: MRAVIVAVGVAFLVSLFCTPIAIKVFTRLKAGQPIRAEGPVMHQGKKGTPTMGGVVFILATVIAYVAGHLALTTLPDAQIAQVEPTITALVLLGLMVFSGAVGFIDDFLKVRKRHSGGLNKRGKLLGQILVGAVFGVIALYFPSTMTDSQGTLTNTETVGSTTLSFIRDIPALELTKVGAVVLFIFVVMAATNGVNLTDGLDGLATGASVMVLAAYALIAFWQYRHWCADPNYTQEYCYAVRDPLEVALIAGAAAGACVGFLWWNTSPARIFMGDTGALGLGGLIAGMAMSTRTILLLPIIGGLFVIITMSVVIQIISFRTTGKRVFRMSPLQHHFELAGWSEVNIVVRFWIIAGIGVAIALGLFYSEFLARVG
What is the function of this protein?
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
What are the official names of this protein?
Phospho-N-acetylmuramoyl-pentapeptide-transferase, UDP-MurNAc-pentapeptide phosphotransferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 4 family. MraY subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: LUXS_LIMRJ
Sequence: MAKVESFTLDHTKVKAPYVRLITVEEGPKGDKISNYDLRLVQPNENAIPTAGLHTIEHLLAGLLRDRLGGVIDCSPFGCRTGFHLITWGEHSTTEVAKALKSSLEEIAYKTKWEDVQGTTIESCGNYRDHSLFSAKEWSKKILDEGISDKPFERHVVD
What is the function of this protein?
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment.  The regulation of gene expression in response to changes in cell density is called quorum sensing.  Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
What are the official names of this protein?
S-ribosylhomocysteine lyase, AI-2 synthesis protein, Autoinducer-2 production protein LuxS.
What is the protein family that this protein belongs to?
Belongs to the LuxS family.
Protein: PG031_MONPV
Sequence: MDTIKIFNHGEFDTIRNELVNLLKVVKWNTINSNVTVSSTDTIDISDCIREILYKQFKNVRNIEVSSDISFIKYNRFNDTTITDDNMGYYLVIYLNRTKSLKTLIYPTLETVISSSDDIMFSKSLNFRFENTKREYKLVMCSISLIYKPSICRIQYDNNKYIDISDSQEGNNLCYCVITMDPHHLIDLETMCVLVDKSGKCLLVNEFYIRFRKNHIYNSFVDICMDHIFELPNTKELFTLCNDDGRNIAWDNDKLESGNNTWIPKTDDEYMFLSKLMNIAKFNNTKFDYYVLVGDTDPCTVFTFKVTKYYININYE
What is the function of this protein?
Plays a role in the inhibition of host NF-kappa-B activation.  Mechanistically, blocks the subunit p65/RELA translocation into the host nucleus.
What are the official names of this protein?
protein OPG031.
What is the protein family that this protein belongs to?
Belongs to the poxviridae OPG031 family.
Protein: TNAA_SALRD
Sequence: MDTIIEPFRIKSVEPIQLTSRAERERMIRDAHYNLFNLHADDVIIDLLTDSGTSAMSAAQWAGLMQGDESYAGSPSYFRFEEAVKDLMPFEHVIPTHQGRAAERILMGIVAGPDAKIPSNTHFDTTRANIEATGAEAVDLVIDAGHVPDAEHPFKGNINLDRLEALLDAEGDRVPIVMLTVTNNTGGGQPVSLANIRGAKALCDTYDVPLVLDACRFAENAYFIKQREDGYGDRSVKEIVREMFSHADGMTMSAKKDALVNIGGWLALDDDAWARKARNQLILTEGFPTYGGLAGRDLEAIAVGLQEIVDEDYLEYRMASTRYLGEALTELGVPIVKPVGGHAVYIDAKSLLPHIPPLDYPAQSLAVALYVTGGIRGVEIGSVMFGRQPDGSEEPADQELLRLAIPRRVYTQSHVDYVIECFEALVGRKGALCGYEITEEPPQLRHFTAHLRPKAPEAVHHETDGPVEASS
What are the official names of this protein?
Tryptophanase, L-tryptophan indole-lyase, TNase.
What is the protein family that this protein belongs to?
Belongs to the beta-eliminating lyase family.
Protein: PAND_SALTY
Sequence: MIRTMLQGKLHRVKVTQADLHYEGSCAIDQDFLDASGILENEAIDIWNVTNGKRFSTYAIAAERGSRIISVNGAAAHCAEVGDIVIIASFVTMSDEEARTWRPKVAYFEGDNEMKRTAKAIPVQVA
What is the function of this protein?
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
What are the official names of this protein?
Aspartate 1-decarboxylase, Aspartate alpha-decarboxylase.
What is the protein family that this protein belongs to?
Belongs to the PanD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RHOAD_DANRE
Sequence: MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDSKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELIKMKQEPVKPEEGRDMANRISAFGYLECSAKTKDGVREVFEMATRAALQVRKRKKRSGCLLL
What is the function of this protein?
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
What are the official names of this protein?
Rho-related GTP-binding protein RhoA-D.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rho family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.