PharMolix/UniProtQA huggingface dataset:
Protein: RL14_ANAPZ
Sequence: MIQKNAILDVADNSGARKVLCIGFLGGKKSATVGDVIVVSAKVAAPKGRVTKGKVYKAVIVRVKGPIRRLDGSIIRFSSNAVVLVNDQGDPLGTRVFGPVRKFPVGEFTKVMSLAVEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RTCB_THEKO
Sequence: MREMVPLKRIDKIRWEIPKFDKRMRVPGRVYADDQLIEKMKQDRTLEQAANVAMLPGIYKYSIVMPDGHQGYGFPIGGVAAFDAKEGVISPGGVGYDINCGVRLIRTNLTKDEVRPKIKELVDTLFKNVPSGLGSKGRVRLHWTQLDDVLADGAKWAVDNGYGWERDLEHLEEGGRMEGADPDAVSQKAKQRGAPQLGSLGSGNHFLEVQYVDKVYNEEIAKAYGLFEGQVVVMVHTGSRGLGHQVASDYLRIMEKANRKYGVPWPDRELVSVPFQSEEGQQYFSAMKAAANFAWANRQMITHWVRESFEEVFKRKAEDMEMEIVYDVAHNIAKLEEHEVDGKKVKVVVHRKGATRAFPAGHPDVPRAYRDVGQPVLIPGSMGTASYVLAGAEGSMRETFGSSCHGAGRLLSRKAATRQYRGDRLRNELLQRGIYVRAASLRVVAEEAPGAYKSVDNVVQVVHEAGIANLVARMRPMGVAKG
What is the function of this protein?
Essential for tRNA splicing and maturation.  Acts by directly joining spliced tRNA halves to mature-sized tRNAs.  Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
What are the official names of this protein?
tRNA-splicing ligase RtcB, 3'-phosphate/5'-hydroxy nucleic acid ligase.
What is the protein family that this protein belongs to?
Belongs to the RtcB family.
Protein: RR9_GUITH
Sequence: MIENLKTNYTGTGHRKQAIARVYLTPGSGLIEVNGIKGELYFQYSPNYIRLSKSPLTTLGLENKYNIYVNAHGGGLTGQVEAIRLGLARALCKLNPENRTALKFEGYLTRDSRITERKKYGLKKARKAPQFSKR
What are the official names of this protein?
30S ribosomal protein S9, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS9 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: NIT2_DICDI
Sequence: MYRGLINSFKNTSKFSTSLFNNNNNCSTTTKSFTHISQQLRKVHLMADKEKVFKFAGIQLLCGDNKEENVQNAIKHIDEAAKNGAKLISLPECFNSPYSTSTFEKYSETEDGETVKKLSEAAKRNQIFLVGGSIPEIDKATGKIYNTCFIFNDKGEVVKKHRKIHLFDIDVPNKIRFKESETLTPGDSFSVVDIGYCKIGVAICYDIRFPELAMLYSKMGAKFLIYPGAFNMVTGPAHWELLQRGRAVDNQVFVAAISPARNPSSTYQAWGHSTIVNSWGTILATTDEHQSIIYSDIDLNTLNETRSSIPIYSQKRDDLYKLDSIKKQ
What are the official names of this protein?
Nitrilase homolog 2.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Protein: T2R31_PONPY
Sequence: MITFLPTIFSILVVVIFVIGNFGNGFIALVNSIEWVKRQKISFADQILTALAVSRVGLLWALLLNWYSTVFNPAFYSVGVRTTVYDVWTVTGHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVILVMLLGPLLFLACQLFVINMKEILRTKEYEGNMTWKIKLRSAMYLSDATITTLANLVPFTLTLLSFLLLICSLCKHLNKMQLHGKGSQDPSTKVHIKVLQTVISFLLLCAIYFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHPFILIWGNKKLKQTFLSVLRQVRYWVKGEKPSSP
What is the function of this protein?
Receptor that may play a role in the perception of bitterness and is gustducin-linked.  May play a role in sensing the chemical composition of the gastrointestinal content.  The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).
What are the official names of this protein?
Taste receptor type 2 member 31, T2R31, Taste receptor type 2 member 44, T2R44.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor T2R family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: Y691_RICTY
Sequence: MDIKLLYRLAKYLRFYKKDLIIVMISLLSVSASLLLIGSVFRNLIDKGLAEDNILSVNKSILYICLLIVILSVASFFRSYFINNVAEKIVNQIRKEAYSNLINYEIEEYEELKIGDIISRLTNDIDQIATLIVNFLSFFIRNSVMLIGGITLMFFESFKLASIVIVTIPILLVPLIKFGKHVKSLSKKALESKSLLVSDIDETFNNIRVIYAFNHQINKISDFDTKLQSYLIYCKIRLKIRALFFAISIAVIFLTITLIVWIGASDIVQGDLSAGQIISFIYYAIIAGVSSGGIFELLSEIHLPTTALERIITIIDKISIVHNNYYALNNPDTVSIEFKNVDFTYNSRPNLKIINNMSLKINANKFVGIVGRSGAGKSTLIQLLLRFYRQDNGTILINNQDISRINPTDIRKFIAYVPQEASIFSDTIKSNIIFGNNKASDYEINEIIKITGIEEFSNKLHDGINTKIGEKGVRLSGGQKQRIAIARALLRKPKILLLDEAMSALDTMSEQKLLNAIKKIMKGNIIISIAHRISSIESADYILVIDKGKVVTAGSHYDLSKNSEIYRNICREQLTI
What is the function of this protein?
Part of an ABC transporter complex.  Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity).
What are the official names of this protein?
Putative export ATP-binding/permease protein RT0691.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: ARNC_WIGBR
Sequence: MLNFKKLSIIIPVYNEQDSLIELIKRTVNTCSKLKIKYEIIIIDDGSNDKSINILEKEALKQNSKIVAIFLKKNYGQHSAIMAGFKHSSGDLVITMDADLQNPPEEIPKLILNAEKGYDVIGTFRQNRKDNWFRKISSRLINIIIQIVIGKSMKDYGCMLRAYNRNIINSILEYNKKNIFIPILANTLSKNIIEIPVLHYEREFGCSKYNLIKLIKLIYDLFFCISFNLIKKNKMFNIFIILIFLAVLMSIVFFFIFFLKIKLNIFYKILFIPIIITLFLIKSFIIIILKILIDIFFVKAKKNSIYYINKIIKNNFSKKKDVT
What is the function of this protein?
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate.  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase, Undecaprenyl-phosphate Ara4FN transferase, Ara4FN transferase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 2 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: HEM6_YERPB
Sequence: MNSPDIALIKTYLLTLQDNICAALAQADGHAEFTEECWVREEGGGGRSRVLVNGAVFEQAGVNFSHVSGAMLPASATAHRPELAGRSFQALGVSLVIHPLNPYLPTSHANVRFFIAEKPGEDAVWWFGGGFDLTPYYGFEEDAIHWHQVAHSLCQPFGEQIYPRYKKWCDDYFYIKHRQEARGIGGLFFDDLNSPDFMTCFNFTQAVGDGFLAAYMPIVARRKALGWGDRERQFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSLPPLVRWEYNYQPEADSAEAALYRDFLPVKDWLAIKGETH
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_DESDA
Sequence: MKVRPSVKKICPKCKVIRRKGVLRVICENPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: NA11_ANTXA
Sequence: GVPCLCDSDGPNVRGNTLSGTYWLAGCPSGWHNCKSSGPNIGWCCKK
What is the function of this protein?
Weakly inhibits voltage-gated sodium channels (Nav).
What are the official names of this protein?
Delta-actitoxin-Axm1c, Delta-AITX-Axm1c, PCR1-2, Toxin PCR1.
What is the protein family that this protein belongs to?
Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.
What are the subcellular locations of this protein?
Secreted. Nematocyst.
Protein: ADD_ECO27
Sequence: MIDTTLPLTDIHRHLDGNIRPQTILELGRQYNISLPAQSLETLIPHVQVIANEPDLVSFLTKLDWGVKVLASLDACRRVAFENIEDAARNGLHYVELRFSPGYMAMAHQLPVSGVVEAVIDGVREGCRIFGVQAKLIGIMSRTFGEAACQQELEAFLALRDQITALDLAGDELGFPGSLFLSHFNRARDAGWHITVHAGEAAGPESIWQAIRELGAERIGHGVKAIEDRALMDFLAEQQIGIESCLTSNIQTSTVADLAAHPLKTFLEHGIRASINTDDPGVQGVDIIHEYTVAAPAAGLSREQIRQAQINGLEMAFLSAEEKRALREKVAAK
What is the function of this protein?
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
What are the official names of this protein?
Adenosine deaminase, Adenosine aminohydrolase.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Protein: NIFX_SINFN
Sequence: MNSVRRLSLVTDEIQPRRSGALRIAIATQDMKVLNAHFGSAKHFAVYDVSRDGWDFVEAVSFDDVSDESGKHPIEGEDRITPKVTALTGCHLLFCRAIGGPSAARVVSAKIHPIRVGEPEAIQDVLSRTQKMLKTAPPPWLRKVLAQAGVAEKKPFEDED
What are the official names of this protein?
Protein NifX.
What is the protein family that this protein belongs to?
Belongs to the NifX/NifY family.
Protein: SAHH_MARSD
Sequence: MLKVDSKLDYKVADISLADWGNKEMQLSEREMPGLMSIREKYGKEKPLKGLKVMGSLHMTIQTAMLIETLHALGADIRWASCNIFSTQDHAAAAIAANGTAKVFAWKGETLEEYWWCTEQALTWPDGSGPDLIVDDGGDATLLIHHGVKAEKDASILDEKTDNKEFQCVLDRLKLSVAETPGKWTAIAEKVRGVSEETTTGVHRLYQMQEAGELLFPAINVNDSVTKSKFDNLYGCRESLADGIKRATDVMIAGKVVVVVGYGDVGKGCAQSMRGFGARVLVTEIDPICALQAAMEGFEVCTMANAVERGDVFVTCTGNYHVITGEHISKMKDEAIICNIGHFDNEIEMGYLENSKTAKKIEIKPQVDKWVMESGKSVIVLAEGRLVNLGCATGHPSFVMSNSFTNQALAQIDLAKNEYEPKVMILSKKLDEEVARLHLERLGVELDVLSKEQADYISVDVEGPYKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXR_PROA2
Sequence: MKSLSILGSTGSIGLSTLDVVRQHPDRFTITGLAEGHDVTLLAEQIREFKPSIVSVRDEASANQLRELIGESGPEIRWGIEGAAVVGEADGSDMVVSAIVGAAGLVPTVRAIKAGKDIALANKETLVVAGQLVSELVREHKVQLLPVDSEHSAIFQSLSGHRTEDIERIILTASGGPFRKTPAEELKLVKPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFNMPAEKIGVVVHPQSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALSWPERCESGIKKLDLTQIGTLTFEEPDMKRFPALRLAFDALREGRTYPAVLNAANEIAVAAFLNNNIGFTDIPAIVDKTMQAHEALTPVDLDEYLAVDRWARETAAALTL
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: SSR3_SCHPO
Sequence: MSNNSRLPENGVQSGNGEDAELKKSMRIIEREIPDSLLEKIPEAEDYIALQDLERKLDSLIVRKRFDLQDSLSRNSHKTRILRMYIHSTVANQSWQQKGENQENNSGDINSLPIPEWTLHIEGRLLVNPDDEDDKAFELAPFTNFFRKIAIQILRSDDLYPSGNYVEWNKLPDNSNTSNGITVTRKGDQSVDVKIMLYPEEHPERYKLSKAFANILGIREGTRPDIVSYLWQYIKFHRLQDMEEKRLINCDKALRDLFEADRLYFPRIPELMNRFLEPIDPIVIPYTINVSEHTVEKVTIFDIRINTEDPRHSQIRSFLATMMSQDKIRSIDDKLTELIQAITYSQSKYDFMKKFSESPIEFINEWIESQSRDLEIVLDGTNMNYAEKRSADYYQQPWVHESAFHYLNLLNSKKQQSVLNASAKK
What is the function of this protein?
Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning.  Controls particularly membrane and organelle development genes.  Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes.  It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
What are the official names of this protein?
SWI/SNF and RSC complexes subunit ssr3.
What is the protein family that this protein belongs to?
Belongs to the SMARCD family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: FOLD_KOSOT
Sequence: MGILLDGKPVAKMIYAEIKEWLGNLQEKPPKLVLFCSEPDDSTKTYMNSIVKRGGKLGISVEICHAGENPVEEIKKLNESRDVAGVMIMHPLKNVDEKLVVSALSLEKDVEGRTPGNLGGIMTGDESFAPPTAEAVMEILRFYDVSLSGKDVTIVGRSTTVGKPLSMLMLKKGIDATVTICHSRTKNLVEKIKRANVLVSAVGRAGFITKEMVGKDSIIIDVGINLYDGKIVGDVDFEQVEPEVAAITPVPGGVGIVTTAILFRHFMVSSRRMVGRR
What is the function of this protein?
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
What are the official names of this protein?
Bifunctional protein FolD.
What is the protein family that this protein belongs to?
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Protein: KMO_MOUSE
Sequence: MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSYRGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLTAVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKKPRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMPFEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY
What is the function of this protein?
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn).  Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development.  Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
What are the official names of this protein?
Kynurenine 3-monooxygenase, Kynurenine 3-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Multi-pass membrane protein.
Protein: ARP3_CAEBR
Sequence: MSSHQLPACVIDNGTGYTKLGYAGNTEPQFIIPSAIAVKDKVASSNAQALRWNNRVGGAGIDDLDFFIGDEALSPAASNYTVKYPIRHGIVEDWDLMERYWEQCIFKYLRAEPEDHFFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALTASWQSREASDRSLTGLVIDSGDGVTHCIPVADGYVIGSCIKHIPIAGRDITYFIQNLLREREHTIPAEQSYEVAKTIKEKFCYVCPDVMKEFVKYDTDSSKWLRTYDGINSITKRPFSVDVGYERFLGPEIFFHPEFCNPDFTTPISDTIDTLIQQCPIDVRRGLYENIVLSGGSTMFKDFARKLQRDVKRLSDARLQMSETLSGGRLKPKPIDVQVISHKMQRYAVWFGGSMLASTSEFYQVSHSKAEYMEKGPSICRYNPVFGALT
What is the function of this protein?
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.  Seems to contact the pointed end of the daughter actin filament (By similarity).
What are the official names of this protein?
Actin-related protein 3, Actin-like protein 3.
What is the protein family that this protein belongs to?
Belongs to the actin family. ARP3 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y2797_LACP7
Sequence: MINFNEVLETNKMIEQENLDVRTITLGISLLDCISSNLEELNQNIYDKITTVAKDLVTTGKKIERQFGIPVVNKRISVTPIAMIGASACKTPSDFVTIAKTLDRAANTVGVNFIGGYSALVSKGMTSSERLLIESIPEALAVTERVCSSVNVGSTKTGINMDAVKLLGQIMLDTAEYTKEKDSLGCAKLVIFCNAPDDNPFMAGAFHGVTEADAIINVGVSGPGVVKTALESVRGEDFGTLCETIKKTAFKITRVGQLVAMEASKMLNIPFGIVDLSLAPTPAVGDSVAEILQEIGLEYPGAPGTTAALALLNDSVKKGGVMASSYVGGLSGAFIPVSEDQGMIDAVRAGCLTLEKLEAMTCVCSVGLDMIAIPGDTKATTISGIIADEMAIGMINQKTTAVRLIPVIGKKVGDIAEFGGLLGYAPIMPVNNFSCDNFVNRGGRIPAPIHSFKN
What are the official names of this protein?
UPF0210 protein Cphy_2797.
What is the protein family that this protein belongs to?
Belongs to the UPF0210 family.
Protein: TRPR_ECO57
Sequence: MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RPGF1_CAEEL
Sequence: MERIVSRVRRLSPLHTFSDALLISLLSESDFQPDSIQQGVVLFEKDEPTEYWYLLLSGEVQLYSKTYTGDFNHLKTLRCGALFGDLSTLTHSCSCLVTRPAQLIRIAQNHFLSVYNKHGDHLQPFIIIMHDILTDETPSDPIHPHSSGLFNGQRSMDLISTEINPSEIVSVSTNGMLSKMILPSIPNQREKPMNRVVVNQQKNEERNFIEFHNPTGIEKQIRDSGGILHRKMLTDNHQVIRDITTEHTRVQNCMIGAEMIDWLLTLFVSTSTTCSSLSRIQMSAIWQVLLNNGLISHIDGEHQFLDKTNSYYRWVQQFRSRNKVAPSIEEVSKSITLLSSVAPETLFLMIVSKPGFERSPEELEVVYEELTFIKALSHLSTMVKRQLSNFVKVEQYVHAGSVVFRQGEIGVYWYIVLKGAVEVNVNGKIVCLLREGDDFGKLALVNDLPRAATIVTYEDDSMFLVVDKHHFNQILHQVEANTVRLKDYGEDVLVLEKVDIPRGAALENSNSCNFNCGYSVMAGKAEKILEYVLETRIDALGDDISELDVFVEDFILTHDAFMPDNTVCNFLKSYYFRTPYRATRDSITDSCTEEVRCKRRVVQFVYVWCSLLRVNFFLNPVTNSFVEELFCHVIDDRKRLGGMEDILTRIGSIRSTRENMQLVLARHPAIVLDCGVLSAHTPCPVLPSDVCNQIIYLADTTCFVLPIRVDKTAEEICELSRRRMSFSAEPLNLVEVKSNGEKLIFSPNDRAIPTVLSLNSKLYVVNREEIPLLVPMEDQNGPTPSSHSSILHLIDSQELAHQLFLFHLQLLRSTDSNELLYQVIGRESFPLSMPFNLDLLVRRFNEVQHWSTTEILLATEENRMEILKKFISIATIAREYRDLLTVFAITLGLSHTSISRLTLTWSKLPPASLKTFSELENLLDPTRNHRMYRLLVSKMSSPYIPFVPLILKDLMFIHQGNKSFYNGLVNFEKMHMFAKIFRSFRQCKSQMDNGAEHEFIEPQSLIRNLRVIDNQKKLMQLSYEIEPKSAPKRNVIFH
What is the function of this protein?
Guanine nucleotide-releasing protein (By similarity).  Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1 (PubMed:22897658).
What are the official names of this protein?
Rap guanine nucleotide exchange factor 1, Exchange protein activated by cyclic AMP 1.
Protein: UVRC_SYNJB
Sequence: MTVPLIHSRDVLESRLKEIPAEPGVYLMRDATDQILYVGKSKKLRSRVRSYFRFTSDLSPRIQRMVAQVCEIEFIVTDNESEALALEDNLIKTHQPPYNVLLKDDKKYPYLCITWSEPYPQLYITRHRRLDRNQDKYYGPYTDVGLLRHTLGLVKRIFPLRQRPKPLYKDRTCLNYDIGRCPGVCQGLISPEEYRKTLTQVAMIFQGQTDELIRELQEKMIQAAEQENYEAAARYRDQIRGLEQLGESQKVSLPNSTVSRDALALAMNDSRACIQLFQVRAGKLVGRLGFVAENRGDDPGLILQRALQEHYQYCDPVEIPSEILTQYELPDHDFLESWLSQKKGRKVSLVAPQRQSKAELIELVERNAQLELTRTQRLADRDAAALERLAEVLDLPDVPRRLEAYDISHIQGSDAVASQVVFIDGLPAKQHYRRYKIRNPEVRPGHSDDFASHAEVARRRFSKMTPEDQPDLVLIDGGKGQLSAVMAVLADLGLDHLPVIALAKREEEIFLPGNPVPLRLPAQDPARLLLQRLRDEAHRFALAFHRQQRKARQHASTLDEIPGLGKYRQKLLMEEFRSIARIQVASEDQLAQVPGIGPKIARQIYRYFHPETQAESPETAQVE
What is the function of this protein?
The UvrABC repair system catalyzes the recognition and processing of DNA lesions.  UvrC both incises the 5' and 3' sides of the lesion.  The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
What are the official names of this protein?
UvrABC system protein C, Protein UvrC, Excinuclease ABC subunit C.
What is the protein family that this protein belongs to?
Belongs to the UvrC family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GSFF_PENAE
Sequence: MTVLFILSAGLVAVFGYLVSWFIYCRTLHPLSKVPGPFWPSVTRLWLTYAVSRGELDVVQRDLHRRYGPLVRIAPDEIACADPEAIRKIYSTTSPLNKSDFYHIWDVGAFSKYPNAFAIVDENMHFERRRIVSSVYSMSTVLTLEPYIDNCSRLFVKRMTERTVPHEAIDLGDWFLWYAYDVIGELFFGHSLGFIENRGDEGGFLASLEVMLPVLTIAAASSPLVRGLIMGLFTLSSTARKGLKGMNHIIETARASVDKRASAVAEPGKGERKDLLHNLLNIVSSKGDKLDFGIEDVKNEAFAALTAGADATMIELQAIFYYLVKDRSVYEELRKEVDQAVETGKLSEFPSYSEVVQLPLLKATIKEALRLHPAVGFTMPRVVGQAGIELLGMYIPPGWKVGMNAAVVGRDEGVYGTDANTFRPERWIERTDSDMDRCNNLVFGAGTRTCIGKQIALSEIYKMVPLLIRKFDFALVDPSKSWTTHDYFFNKQSGVQVKVTVRGL
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of griseofulvin, an important antifungal drug that has been in use for a long time for treating dermatophyte infections (PubMed:20534346, PubMed:23978092).  The first step of the pathway is the formation of the heptaketide backbone by gsfA which is initiated by priming with acetyl-CoA, followed by sequential condensations of 6 malonyl-CoA units (PubMed:20534346, PubMed:23978092).  The resulting benzophenone can undergo a spontaneous dehydration to form norlichexanthone (PubMed:23978092).  However, the true precursor for the griseofulvin biosynthesis is not norlichexanthone, but the heptaketide benzophenone that is O-methylated at 3-OH by gsfB to produce griseophenone D which is further methylated at 9-OH by gsfC to yield griseophenone C (PubMed:23978092).  Griseophenone C is then substrate of halogenase gsfI which is responsible for the regio-specific chlorination at the C13 position to form griseophenone B (PubMed:23978092).  The cytochrome P450 gsfF catalyzes the coupling of orcinol and phloroglucinol rings in griseophenone B to form desmethyl-dehydrogriseofulvin A which is further methylated at 5-OH by gsfD to yield dehydrogriseofulvin (PubMed:23978092).  Finally, gsfE performs stereospecific reduction of enone 18 of dehydrogriseofulvin to afford the final product griseofulvin (PubMed:23978092).
What are the official names of this protein?
Cytochrome P450 monooxygenase gsfF, Griseofulvin synthesis protein F.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
Protein: AROB_ACIB5
Sequence: MQTLHVELGERRYPIFIGSQLDPKQLLEPYIHGQQVMIVSNVTVAPLYLSHYQEALESLGKTVATCILPDGEKYKDIQHLNLIFDALLEAGFNRDCTVLALGGGVIGDMAGFASACFQRGVYFVQVPTTLLSQVDSSVGGKTGINHPLGKNMLGAFQQPQVVLADMAQLNTLPERELSAGLAEVIKYALLGDEDFLVWLEENMDGLVARDADLLAEAVYRSCAHKARIVANDEKEQGERALLNLGHTFGHAIESYLGYGTWLHGEAVATGMVMAADLSQRLGWISNEDVARTKKIIQRANLPISCPQIPLDDFLGYMAHDKKVLNGQLRLVLLKQLGQAVITKDFDVELMKQAILANQHG
What is the function of this protein?
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
What are the official names of this protein?
3-dehydroquinate synthase, DHQS.
What is the protein family that this protein belongs to?
Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRMD_BURPS
Sequence: MDEATQSAIQFDVVTLFPEMFRALTDWGITSRAVKQGRFGLRTWNPRDFTTDNYRTVDDRPYGGGPGMVMLAKPLEAAIGAAKAAQAAQGVATSRVVMMSPQGAPLTHERVARMAAEPGVVLLCGRYEAIDQRLIDRCVDEELSLGDFVLSGGELPAMALMDAVVRLLPGVLNDAQSAVQDSFADGLLDCPHYTRPEEYEGVRVPDVLLGGHHAEIERWRRQEALRNTIAKRPDLIARARREKLLSRADEAWLASLAKEAKQAS
What is the function of this protein?
Specifically methylates guanosine-37 in various tRNAs.
What are the official names of this protein?
tRNA (guanine-N(1)-)-methyltransferase, M1G-methyltransferase, tRNA [GM37] methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase TrmD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MCR1A_VANPO
Sequence: MFARIARINPKILPFVIGAPTIALCSYYYSSGAFLRNESSKVFIGDNNWIDLPISRIEEISHDTKRFTFKYPSQDSVSGLVVASALLTKFVTPKGSNVIRPYTPVSDVDEKGSLDLVIKHYPDGKMTNHIFSLKVNDTLSFKGPIPKWKWVPNSFESITLIGGGTGITPLYQLIHAITKNPNDKTKIRLFYSNKTSQDVLMKKELDELQAKYPDQLRITYFITTPDKGYKGESGFISKEFIASNADKPSPKSHVFVCGPPPFMNAYSGDKKSPTDQGELVGILKELGYTIDQVYKF
What is the function of this protein?
May mediate the reduction of outer membrane cytochrome b5.
What are the official names of this protein?
NADH-cytochrome b5 reductase 2-A, Mitochondrial cytochrome b reductase A.
What is the protein family that this protein belongs to?
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
What are the subcellular locations of this protein?
Mitochondrion outer membrane; Single-pass membrane protein.