PharMolix/UniProtQA huggingface dataset:
Protein: MSCL_METPP
Sequence: MSFFSEFKEFAVKGNVIDLAVGVIIGGAFGKIVDSIVGDLIMPIVSKLFGGLDFSNYYVGLAGQAAGLPLAEAKKAGAVFAYGNFITVALNFAILAFIIFLMIKQINRLKKDEPAAPPAPPAEDIVLLREIRDALKK
What is the function of this protein?
Channel that opens in response to stretch forces in the membrane lipid bilayer.  May participate in the regulation of osmotic pressure changes within the cell.
What are the official names of this protein?
Large-conductance mechanosensitive channel.
What is the protein family that this protein belongs to?
Belongs to the MscL family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DIP1_SCHPO
Sequence: MEFTDVFYNLENEKQFLAEIDELLTIPYEKNELEIGVSKFLSFINKYGEPYLITEFQLQRCMEKFLNSPLYQLDENAVLSIFYDCFFFLKEQQTLKFIIIVFQSEIQENEYCLRLLASTGFIPVLIKAMKQFKDRSENVAFTSFRYALFLVYYICRSRRLSPTDLVAIDEYFLVNLFKTSEEAWNDEDMDSFGMCVLTLLSINEQFMLVRLASKGSFEIANGIMDLLSSSKVDNGIYSEGLVFTLNREKDPRSRMLILKQLFLLFTTPATYEIFYTNDLNVLIDIFIREINNIPDELSDLRYAYLQVLIPLLENTQVRHPPHYKTKCIVDAVNNVLISHSKSSNMEDARTTDVAIRVLEVPWLQQEMKSLGTAQ
What is the function of this protein?
May be involved in protein-linked oligosaccharide phosphorylation.
What are the official names of this protein?
Protein dip1.
What is the protein family that this protein belongs to?
Belongs to the LDB17 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cell tip. Cell septum.
Protein: E13B_BRACM
Sequence: MLASSPMLLFLLSLLMAYNFDTTAGQIGVCFGQMGNNIPNPSEVVAMFKQYSIPRMRMYGPNPDALNALRGSNIEFILDVPNGDLKRLADSQAEANTWVRDNVQKYNDVRFKYISVGNEVKPGEPGAAALIQAMQNIDRALSAAGLSNIKVSTTTFMGPSRNTYPPSRGRFKDEYRNFLQPVIGFLVNKRSPLLVNIYTYFGYMNRDVSLQFALLQPNSNNEFTDPNNQLRYLNFFDANLDSVYAALEKSGGGSLDVVVSESGWPTQGGPGASVPNAEAYVNNLRLHVNKNGSPKRQEAIETYIFAMFDEAPRQTSPNDEYEKYWGMFSPTTRQLKYGVKFN
What is the function of this protein?
Is thought to be an important plant defense-related product against fungal pathogens.  Accumulation of the glucanase can be detected as early as 4 hours after inoculation.
What are the official names of this protein?
Glucan endo-1,3-beta-glucosidase, (1->3)-beta-glucan endohydrolase, (1->3)-beta-glucanase, Beta-1,3-endoglucanase.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 17 family.
What are the subcellular locations of this protein?
Vacuole. Note=In intact tissues.
Protein: RUVB_CERS5
Sequence: MTSSDPTLRPERLPEDMDRALRPQSLEEFVGQAEARANLRVFIESARMRGEAMDHTLFHGPPGLGKTTLAQIMARELGVGFRMTSGPVLAKPGDLAAILTNLEPRDVLFIDEIHRLSPVVEEVLYPALEDFALDLVIGEGPAARTVRIELQPFTLVGATTRLGLLTTPLRDRFGIPTRLQFYTEAELTLIVARGARMMGVDSDPEGTQEIARRARGTPRIAGRLLRRVVDFALVEGDGRLTQAIADRALTRLGVDHLGLDLGDRRYLSLIAENYGGGPVGIETIAAALSEARDAVEEVIEPYLLQQGLIQRTPRGRMLAHKAWRHLGLEAPKGPGQADLFG
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MNMA_MYCSK
Sequence: MRVLVAMSGGVDSSVAAARMVDAGHDVVGVHLALSATPGTLRTGSRGCCSKEDAGDARRVADVLDIPFYVWDFADRFKEDVIDDFVASYERGETPNPCVRCNEKIKFSALAGRALALGFDALATGHYARLSDGRLRRAVDADKDQSYVLAVLTAQQLRHAVFPIGDTPKAQIRAEAAERGLAVADKPDSHDICFIPSGDTRAFLGARIGVRRGAVVDAGGTKLAEHEGVHGFTIGQRKGLGIAGPGPDGQPRYVTGIDAATGTVRVGGAEDLDVWRLTGERPVFTSGAAFGGPVECQVQVRAHGGLADAVASHDAGVLSVELRAPLRGVAAGQTMVIYRPDPEGDEVLASATISGADGR
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y2289_ARATH
Sequence: MEGRRQRLLVFIFGALAITHLVQAQPPDQRGFISLDCGLPVNESPYTDPRTGLTFSSDADFILSGLRGEAGDDNTYIYRQYKDLRYFPDGIRNCYNLKVEQGINYLIRAGFGYGNYDGLNVYPKFDLHVGPNMWIAVDLEFGKDREIIYMTTSNLLQICLVKTGSTIPMISTLELRPLRNDSYLTQFGPLDLIYRRAYSSNSTGFIRYPDDIFDRKWDRYNEFETDVNTTLNVRSSSPFQVPEAVSRMGITPENASLPLRFYVSLDDDSDKVNVYFHFAEIQALRGNETREFDIELEEDIIQSAYSPTMLQSDTKYNLSPHKCSSGLCYLKLVRTPRSTLPPLISAIEAFKVVDFPYAETNPNDVAAMKDIEAFYGLKMISWQGDPCVPELLKWEDLKCSYTNKSTPPRIISLDLSSRGLKGVIAPAFQNLTELRKLDLSNNSFTGGVPEFLASMKSLSIINLNWNDLTGPLPKLLLDREKNGLKLTIQGNPKLCNDASCKNNNNQTYIVPVVASVASVLIIIAVLILILVFKKRRPTQVDSLPTVQHGLPNRPSIFTQTKRFTYSEVEALTDNFERVLGEGGFGVVYHGILNGTQPIAVKLLSQSSVQGYKEFKAEVELLLRVHHVNLVSLVGYCDEESNLALLYEYAPNGDLKQHLSGERGGSPLKWSSRLKIVVETAQGLEYLHTGCKPPMVHRDVKTTNILLDEHFQAKLADFGLSRSFPVGGETHVSTAVAGTPGYLDPEYYRTNRLNEKSDVYSFGIVLLEIITSRPVIQQTREKPHIAAWVGYMLTKGDIENVVDPRLNRDYEPTSVWKALEIAMSCVNPSSEKRPTMSQVTNELKQCLTLENSKRGVREDMGSRSSVEMSTSFTTEINPKAR
What are the official names of this protein?
Probable LRR receptor-like serine/threonine-protein kinase At2g28960.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: COAE_DICNO
Sequence: MIVGLTGGIASGKTLCCNWFAAQGCYIIDADLIAKELVTVGGVVWLQLRAHFGETIFYADGNLNRALLREKMFHNQEIKEKVNQIFHPAVRAEIEKRIHLYPHAFTLLDVPLLFETQLHKICHMVIVVDIPVSLQIARGVCRDGVNSAQMQRIIASQISREKRLSLANFIIDNSNSIAQTYQQCQQIYQQILSLNAA
What is the function of this protein?
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
What are the official names of this protein?
Dephospho-CoA kinase, Dephosphocoenzyme A kinase.
What is the protein family that this protein belongs to?
Belongs to the CoaE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DYM_DROME
Sequence: MGINVSRTADLGSNQWLQRFVGRQHIAHDDEAFWNGLLNYNIVLPENSQDQLNLDSRLEALCQSFIGNNLKTGNFGSLVTVFLEKTSELLSLSDQESNMHVWQTFNALFIIRSLVKYINETGSEFQLLQHFEAMPNAELLQAALEQQQQTPAESATIAMEATEQSAAAAVPVIVDGSKFETFIDALVNLIVVIPVKEFTYHLHLEAVNMLITLLSVHLFAQQPTDKSIVFRTVFKCQHANVLMSALLHFVARIVEVPHTMFGSSSAGSFVFGIAESLLSIFTFRKQPDILKAGQAAGGGELSQRFRTHYPLANQSLLLILILTNHCTAQDNAYRTSLFSCADSKDSPKQGAVSFQIDFSAVYETLCTIVTIDQATLLLYLLLHRNERFYRFVMQQQDLEQLVIPILQTLYNAPDSNSHHIYMSLIVLLILSEDEGFNKNVHTIMLKNITWYTERTISEISLGGILILIVIRTIQYNMLKMRDKYLHTNCLAALANMSGHFRALHPYVAQRLVSLFETLARKHTRLDAQLKEPADSAVFVNVSTTPEDMLQDLSVLEEVLRMVLEILNSCLTNQLVYCPNLVYTLLYKRSVFEGFRSHHAFQDVIQNIDMVVGFFSSRLQRVQEQRGELGVNEVLEVISKGASQWSSDRLRKFPDLKFKYVEEDAPEEFFIPYVWTLVCKYGCVHFSSESIKSVTTDIAC
What are the official names of this protein?
Dymeclin.
What is the protein family that this protein belongs to?
Belongs to the dymeclin family.
Protein: RLMH_LIMRD
Sequence: MNIKIIGVGKLKEKYFKAGIAEYAKRLGRYCKFEIVEVPDEKAPESLSQAEMDEVMAKEGERILDKIKDREYVYALAIKGKERSSEEFAKEINKLTTYGHSDITFVIGGSLGLSPAVLKRADAQISFGRFTLPHQLMRLVLSEQIYRAFTIINGLPYHK
What is the function of this protein?
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
What are the official names of this protein?
Ribosomal RNA large subunit methyltransferase H, 23S rRNA (pseudouridine1915-N3)-methyltransferase, 23S rRNA m3Psi1915 methyltransferase, rRNA (pseudouridine-N3-)-methyltransferase RlmH.
What is the protein family that this protein belongs to?
Belongs to the RNA methyltransferase RlmH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAB2A_PONAB
Sequence: MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
What is the function of this protein?
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.  Rabs cycle between active GTP-bound and inactive GDP-bound states.  In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology.  Required for protein transport from the endoplasmic reticulum to the Golgi complex.  Regulates the compacted morphology of the Golgi.
What are the official names of this protein?
Ras-related protein Rab-2A.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Rab family.
What are the subcellular locations of this protein?
Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (By similarity).
Protein: RPOB_CORK4
Sequence: MLEGPILAVSRQTSLTSGIPGATKRYSFAKIKEPIEVPGLLDLQRDSFAWLIGAPEWRAKKQAESEEGARITSGLEDILEELSPIEDYSGNMSLTLSEPRFDDVKNTIDEAKDKDINYSAPLYVTAEFTNAMSGEIKSQTVFIGDFPMMTDKGTFIINGTERVIVSQLVRSPGVYFDESIDKSTERPLHSVKVIPSRGAWLEFDIDKRDTVGVRIDRKRRQPVTVLLKALGLSTQDITDRFGFSELMMSTLEHDGVANTDEALLEIYRKQRPGESPTRDSAQALLDNSFFNPKRYDLAKVGRYKVNRKLGLGGGSTTGEHTLTEEDILTTIEYLVRLHAGERTMESPDGTELMIATDDIDHFGNRRLRTVGELVQNQVRVGLSRMERVVRERMTTQDAESITPTSLINVRPVSAAIREFFGTSQLSQFMDQNNSLSGLTHKRRLSALGPGGLSRERAGLDVRDVHASHYGRMCPIETPEGPNIGLIGSLASYARVNPFGFIETPYRRVENGQATDVVDYLTADEEDRHIVAQANTKMDSEGRFVEDTVEVRMKGGNVEVVPASEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLLRNEAPFVGTGMELRAAHDAGDVVIARRSGVVETVCADFITTLGDDGQRDTFLLRKFERTNQGTCYNQKPLVEAGDRIEEGQALADGPGTENGEMALGRNLLVAFMPWEGHNYEDAIILNQRIVEEDVLTSIHIEEHEIDARDTKLGPEEITRDIPNASEDILADLDERGIVRIGADVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSMKVPHGETGKVIGVRVFSREDDDDLAPGVNQMVRVYVAQKRKIQDGDKLSGRHGNKGVVGKILPAEDMPFLPDGTPVDVILNTHGVPRRMNIGQVLELHLGMLAKSGWKVDPESQDPAIKAMLETLPEDLYDVPADSRVATPVFDGTTNEELSGLMRSSRPNRDGDQMVNEFGKSTLIDGRTGEPFQQPISVGYMYMLKLHHLVDEKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMEVWAMQAYGAAYTLQELLTIKSDDVVGRVKVYEAIVKGDNIPDPGIPESFKVLLKELQSLCLNVEVLSADGTPVDLGADDDDLDQANASLGINLSRDERFDADAV
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta, RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
Protein: RL19_LACPL
Sequence: MRQNQLIEKITNEQLRTDIPDFRAGDTVRVHARVVEGTRERIQLFEGVVIKRHGSGISETYTVRKISNGVGVERTFPLHTPRVAAIDVVRQGRVRRAKLYYLRNLHGKAARIPERRRG
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: RFAZ_ECOLI
Sequence: MKNIRYIDKKDVENLIENKISDDVIIFLSGPTSQKTPLSVLRTKDIIAVNGSAQYLLSNNIVPFIYVLTDVRFLHQRRDDFYKFSQRSRYTIVNVDVYEHASKEDKLYILQNCLVLRSFYRREKGGFIKKIKFNILRQIHKELLISVPLSKKGRLVGFCKDISLGYCSCHTIAFAAIQIAYSLKYARIICSGLDLTGSCSRFYDENKNPMPSELSRDLFKILPFFRFMHDNVKDINIYNLSDDTAISYDVIPFIKLQDISAEESKDMTRKKMQYRTSTDSYAN
What are the official names of this protein?
Lipopolysaccharide core biosynthesis protein RfaZ.
Protein: DBR2_ARTAN
Sequence: MSENPPTLFSAYKMGNFNLSHRVVLAPMTRCRAINAIPNEALVEYYRQRSTAGGFLITEGTMISPSSAGFPHVPGIFTKEQVEGWKKVVDAAHKEGAVIFCQLWHVGRASHQVYQPGGAAPISSTSKPISKKWEILLPDATYGTYPEPRPLAANEILEVVEDYRVAAINAIEAGFDGIEIHGAHGYLLDQFMKDGINDRTDEYGGSLENRCKFILQVVQAVSAAIATDRVLIRISPAIDHTDAMDSDPRSLGLAVIERLNKLQFKLGSRLAYLHVTQPRYTADGHGQTEAGANGSEEEVAQLMKTWRGAYVGTFICCGGYTRELGLQAVAQGDADLVAFGRYFVSNPDLVLRLKLNAPLNRYDRATFYTHDPVVGYTDYPSLDKGSLL
What is the function of this protein?
Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:18495659, PubMed:27488942).  Catalyzes the double bond reduction of artemisinic aldehyde to produce (11R)-dihydroartemisinic aldehyde (PubMed:18495659).  Also able to reduce 2-cyclohexen-1-one into cyclohexanone to a lesser extent (PubMed:18495659).
What are the official names of this protein?
Artemisinic aldehyde Delta(11(13)) reductase.
What is the protein family that this protein belongs to?
Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol.
Protein: CH602_ACAM1
Sequence: MAKRIIYNENARRALEKGMDILCESVAVTLGPKGRNVVLEKKFGAPQIVNDGVTIAKEIELEDNIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKEGMRNVVAGANAISLKRGIEKAAGFLVEKIAENARSVEDSTAIAQVGTISAGNDDEVGQMIANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFEKGYISPYFATDTERMEAVLDEPYILLTDKKITLVQDLVPVLEQAARAGKPLLVIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDIAVLTGGQVITEDAGLKLETAKLEMMGQARRITITKDTTTLVAEGNEADVQARCEQIRRQMDETESSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDRKLRLEDAINSTKAAVEEGIVPGGGTTLAHLGPQLASWAADNLTGEELIGATIVERALTAPLKRIAENAGQNGAVIAERVREKEFNVGFDASVNEFTDMFAAGIVDPAKVTRSALQNAASIAGMVLTTECIISDKPEPKENAPTGAGMGGDFDY
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL 2, 60 kDa chaperonin 2, Chaperonin-60 2, Cpn60 2.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAIC_ECO24
Sequence: MDIIGGQHLRQMWDDLADVYGHKTALICESSGGVVNRYSYLELNQEINRTANLFYTLGIRKGDKVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLREESAWILQNSQACLLVTSAQFYPMYQQIQQEDATQLRHICLTDVALPADDGVSSFTQLKNQQPATLCYAPPLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDDVYLTVMPAFHIDCQCTAAMAAFSAGATFVLVEKYSARAFWGQAQKYRATITECIPMMIRTLMVQPPSANDRQHRLREVMFYLNLSEQEKDAFCERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRAGFCYEAEIRDDHNRPLPAGEIGEICIKGVPGKTIFKEYFLNPKATAKVLEADGWLHTGDTGYCDEEGFFYFVDRRCNMIKRGGENVSCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFRFCEQNMAKFKVPSYLEIRKDLPRNCSGKIIRKNLK
What is the function of this protein?
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.  Also has activity toward crotonobetaine and gamma-butyrobetaine.
What are the official names of this protein?
Crotonobetaine/carnitine--CoA ligase.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
Protein: SMS1B_CARAU
Sequence: MQLLSSLVSLLLVLYSVRAAAVLPVEERNPAQSRELSKERKELILKLISGLLDGVDNSVLDGEIAPVPFDAEEPLESRLEERAVYNRLSQLPQRDRKAPCKNFFWKTFTSC
What is the function of this protein?
Somatostatin inhibits the release of somatotropin.
What are the official names of this protein?
Somatostatin-1B.
What is the protein family that this protein belongs to?
Belongs to the somatostatin family.
What are the subcellular locations of this protein?
Secreted.
Protein: LAT_MOUSE
Sequence: MEADALSPVGLGLLLLPFLVTLLAALCVRCRELPVSYDSTSTESLYPRSILIKPPQITVPRTPAVSYPLVTSFPPLRQPDLLPIPRSPQPLGGSHRMPSSQQNSDDANSVASYENQEPACKNVDADEDEDDYPNGYLVVLPDSSPAAVPVVSSAPVPSNPDLGDSAFSVESCEDYVNVPESEESAEASLDGSREYVNVSPEQQPVTRAELASVNSQEVEDEGEEEGVDGEEAPDYENLQELN
What is the function of this protein?
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development.  Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells.  Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
What are the official names of this protein?
Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.
Protein: H3A11_CYRHA
Sequence: MKASMFLALAGLVLLFVVGYASESEEKDFPRELLSKIFAVDDFKGEERGCKGFGDSCTPGKNECCPNYACSSKHKWCKVYLGK
What is the function of this protein?
Selective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC(50)=1270 nM on Nav1. 1/SCN1A, 270 nM on Nav1. 2/SCN2A, 491 nM on Nav1. 3/SCN3A and 232 nM on Nav1. 7/SCN9A).  This toxin suppress Nav1. 7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics.  Short extreme depolarizations partially activate the toxin-bound channel, indicating voltage-dependent inhibition of this toxin.  This toxin increases the deactivation of the Nav1. 7 current after extreme depolarizations.  The toxin-Nav1. 7 complex is gradually dissociated upon prolonged strong depolarizations in a voltage-dependent manner, and the unbound toxin rebinds to Nav1. 7 after a long repolarization.  Moreover, analysis of chimeric channels showed that the DIIS3-S4 linker is critical for toxin binding to Nav1. 7.  These data are consistent with this toxin interacting with Nav1. 7 site 4 and trapping the domain II voltage sensor in the closed state.
What are the official names of this protein?
Hainantoxin-III 11, HnTx-III, Hainantoxin-3.11, Mu-theraphotoxin-Hhn2a, Mu-TRTX-Hhn2a, Peptide F7-18.76.
What is the protein family that this protein belongs to?
Belongs to the neurotoxin 10 (Hwtx-1) family. 15 (Hntx-3) subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: ILVC_NITMS
Sequence: MAQTWKDTDISLDPIKDQTIAVIGYGIQGDAQANNMKDSGLNVIIGLKEGGNSWKKAEADGHKVMSVADATKQADIIHILIPDMIQGQVYKDEIGPNLSEGKALSFSHAAAIYWKWIEAPNNVDLIMIAPKGPGSKVRETYLDNFGTPAIVAVEQDFTGKAWDRTLGIAKAIGSARAGLIKTAFKEEVETDWFGEQADLCGGAASMVTNAFETLVEAGYQPEIAYFEVLHELKLIVDMIQRYGINGMWRRVSETARYGGLTRGPMVMDSANKENMKKVLTMIQDGTFNNEWISEYQKNGKDAFDKYMKQYDEHQIEKVGKEMRKMMWPDSTE
What is the function of this protein?
Involved in the biosynthesis of branched-chain amino acids (BCAA).  Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate.  In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB).  In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
What are the official names of this protein?
Ketol-acid reductoisomerase (NADP(+)), KARI, Acetohydroxy-acid isomeroreductase, AHIR, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase type 1, Ketol-acid reductoisomerase type I.
What is the protein family that this protein belongs to?
Belongs to the ketol-acid reductoisomerase family.
Protein: QUEA_COXB1
Sequence: MKNQWKTSDFDYNLPVELIAQRPLADRSGSRLLYIDRSRRTVSHRQFNGFVEQVKPNDLVVLNDTKVIPARLFGHKQTGGKVECLVERILSKDRFLAHIRASKAPKLGSQIIIADNFKIIIEGRYNDLFECVLHSSASILDLLYQHGRIPLPPYIQREPDKDDQARYQTIFAERAGAVAAPTAGLHFNEETFDALRKKGAAITYVTLHVGAGTFQPVRADSLADHRMHHEWMEVSKAVCDAIAKCRKNNGRVIAVGTTVMRCLETATKNGECRPYAGETDLFIYPGFQFNCVDALLTNFHLPKSTLLMLVCAFGGYELVMEAYQKAVENRYRFFSYGDAMLIS
What is the function of this protein?
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
What are the official names of this protein?
S-adenosylmethionine:tRNA ribosyltransferase-isomerase, Queuosine biosynthesis protein QueA.
What is the protein family that this protein belongs to?
Belongs to the QueA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TRPC5_RABIT
Sequence: MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKQPRRSLSTSSTELSQRDDTNDGSGGARAKSKSVSFNLGCKKKACHGPPLIRTMPRASGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHYMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVRGAAQSSECPLTCSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
What is the function of this protein?
Thought to form a receptor-activated non-selective calcium permeant cation channel.  Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.  Has also been shown to be calcium-selective.  May also be activated by intracellular calcium store depletion (By similarity).  Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).
What are the official names of this protein?
Short transient receptor potential channel 5, Rtrp5, TrpC5, Capacitative calcium entry channel 2, CCE2.
What is the protein family that this protein belongs to?
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.