PharMolix/UniProtQA huggingface dataset:
Protein: SIRB_LEPMC
Sequence: MSTLQDFQIAPAILHRVTVRDASAILFCTLLTVFLFISQGTVRGVKRVGKSRLRTLVTGETPLRFDLEKYGYLGYQQFSKKANKPFLVKIYGLDHYVLPVKYLDSLKTVDHHRLSFAQSLNDFLNVDASLGDLVTHSDMEIAVVTKHLNPRLTTLTPVLVDEANFAFEKELGKLETWKTVNALFLSAFLTNRTSGRVLVGDLCRDDNYLHAMMKYTESVFSSGVAFNGIPLGPFRKIVYYLGARQHRRDLDNAAALVLPEIKRRMAAQAEDPNCRKENDAIQWNLDLPLASPKEGLPLRHAHRVLHLSFAATGTVAILITHMIYNVLMYPEYLEPLREEVMACTKAHGGWTEKAMNEMWKLDSFIRETLRVQPPSVFTAYRTVKNQPFTFPDGFTLPVGSRITFPTLPVGLDPENYESASEFDGFRFFRKREEARLAKKAYNWGATKIDSSFLPFGYGNQACPGRFFGVRKTKILFGKLINDYDFSWAEPRSARPENIVIEGQILVNPTPEIKIKSRVAAGM
What is the function of this protein?
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sirodesmin PL, an epipolythiodioxopiperazine (ETP) characterized by a disulfide bridged cyclic dipeptide and that acts as a phytotoxin which is involved in the blackleg didease of canola (PubMed:15387811, PubMed:18272357, PubMed:19762440).  SirD catalyzes the O-prenylation of L-tyrosine (L-Tyr) in the presence of dimethylallyl diphosphate (DMAPP) to yield 4-O-dimethylallyl-L-Tyr, and therefore represents probably the first pathway-specific enzyme in the biosynthesis of sirodesmin PL (PubMed:19762440, PubMed:21038099, PubMed:24083562).  4-O-dimethylallyl-L-Tyr, then undergoes condensation with L-Ser in a reaction catalyzed by the non-ribosomal peptide synthase sirP to form the diketopiperazine (DKP) backbone (PubMed:18272357).  Further bishydroxylation of the DKP performed by the cytochrome P450 monooxygenase sirC leads to the production of the intermediate phomamide (PubMed:27390873).  This step is essential to form the reactive thiol group required for toxicity of sirodesmin PL (PubMed:27390873).  The next steps of sirodesmin biosynthesis are not well understood yet, but some predictions could be made from intermediate compounds identification (PubMed:18272357).  Phomamide is converted into phomalizarine via oxidation, probably by sirT (PubMed:18272357).  Further oxidation, methylation (by sirM or sirN) and reduction steps convert phomalizarine to deacetyl sirodesmin (PubMed:18272357).  Finally, acetyltransferase sirH probably acetylates deacetyl sirodesmin to produce sirodesmin PL (PubMed:18272357).
What are the official names of this protein?
Cytochrome P450 monooxygenase sirB, Sirodesmin biosynthesis protein B.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: HUTU_PSESX
Sequence: MTSTTPKSPAAFTRHRDGEIRAARGTQLTAKSWMTEAPLRMLMNNLDPQVAENPTELVVYGGIGRAARNWECYDKIVESLTNLNDDETLLVQSGKPVGVFKTHSNAPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWINIGSQGIVQGTYETFVEAGRQHYNGSLKGKWVLTAGLGGMGGAQPLAATLAGACSLNIECQQSRIDFRLATRYVDEQALDLDDALVRIAKYTAEGKAISIALCGNAAELLPEMVRRGVRPDMVTDQTSAHDPLNGYLPKGWTWEQYRDRAVTDPAAVVKAAKASMGEHVEAMLAFQKAGIPTFDYGNNIRQMAKEVGVENAFDFPGFVPAYIRPLFCRGVGPFRWVALSGDAEDIYKTDAKVKELIADDAHLHNWLDMARERISFQGLPARICWVGLGQRAKLGLAFNEMVRSGELKAPIVIGRDHLDSGSVSSPNRETESMKDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHSGMVIVCDGTDEAAERIARVLHNDPATGVMRHADAGYDIAIDCANEQGLNLPMING
What is the function of this protein?
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
What are the official names of this protein?
Urocanate hydratase, Urocanase, Imidazolonepropionate hydrolase.
What is the protein family that this protein belongs to?
Belongs to the urocanase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CP2D6_PANPA
Sequence: MGLEALVPLAVIVTIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQARMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR
What is the function of this protein?
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids.  Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase).  Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA).  Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling.  Catalyzes the hydroxylation of carbon-hydrogen bonds.  Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis.  Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid.  Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
What are the official names of this protein?
Cytochrome P450 2D6, CYPIID6, Cholesterol 25-hydroxylase, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: RPOA_GRATL
Sequence: MTYFQIECVESKTESNRQQYGRFILEPLNKGQGITLGNSLRRTILSDLQGAAIVAVRIAGINHEFSTITGVREDVLEILLNLKKVVLKSHSDTPQIGRIRLQGPAIITTGLFEVPPEILIIDPQQYIATICNNTIFEMEFRIEKGSGYKLVNKGFDKKSIDFLQIDAVFMPVTKFNYTVEEKKISPILIQEKLFLEVWTNGSLSPQEAISEGAQVLHSLFYPLTNLNFQNANNTDNEYEEEINQVLIEELQLSVRAYNCLKRAQINSISDLLDYSQDELLEIKNFGQKSAEEVIEALQNKLGIRLPKEKNIQNT
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit alpha, PEP, Plastid-encoded RNA polymerase subunit alpha, RNA polymerase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase alpha chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: PMA1_AJECA
Sequence: MAHSAASGAASAAHFEKKTPEVAHEEKKPPLPEEEDEDEDMDALIEELESQDGHIDIEDDEDGEPGGARPVPDELLTTDTRHGLTDAEVVARRKKYGLNQMKEEKENLVLKFLSYFVGPIQFVMEAAAILAAGLEDWVDFGVICALLLLNACVGFVQEFQAGSIVDELKKTLALKAVVLRNGRLTEVEAPEVVPGDILQVEEGTIIPADGRIVTEEAFLQVDQSAITGESLAVDKHKGDTCYASSAVKRGEAFMVITATGDNTFVGRGPALVNAASAGTGHFTEVLNGIGTVLLILVILTLLVVWVSSFYRSNSIVTILEFTLAITIIGVPVGLPAVVTTTMAVGAAYLAKKKAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLAEPYCVSGVDPEDLMLTACLAASRKKKGIDAIDKAFLKSLRYYPRAKSVLTQYKVLEFHPFDPVSKKVSAVVLSPQGERITCVKGAPLSVLKTVEEDHPIPDEVDSAYKNKVAEFATRGFRSLGVARKRGEGSWEILGIMPCSDPPRHDTAKTINEAKTLGLSIKMLTGDAVGIARETSRQLGLGTNVYNAERLGLGGGGTMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGASDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYAYVVYRIALSLHLEIFLGLWIAILNTSLNLQLVVFIAIFADIATLAIAYDNAPFSKTPVKWNLPKLWGMSVLLGIVLAVGTWITLTTMLVGSENGGIVQNFGRTHPVLFLEISLTENWLIFITRANGPFWSSIPSWQLSGAILLVDIIATLFTIFGWFVGGQTSIVAVVRIWVFSFGCFCVLGGLYYLLQGSAGFDNMMHGKSPKKNQKQRSLEDFVVSLQRVSTQHEKSS
What is the function of this protein?
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump.  The proton gradient it generates drives the active transport of nutrients by H(+)-symport.  The resulting external acidification and/or internal alkinization may mediate growth responses.
What are the official names of this protein?
Plasma membrane ATPase, Proton pump.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: RS4_FLAPJ
Sequence: MARYTGPSTRIARKFGEAIFGDDKSFEKRNYPPGQHGMAKKRGKKSEFAIQLMEKQKAKYSYGILEKQFRGLFKKAAASKGVTGEILLQLCEARLDNVVYRMGIAPTRRAARQIVSHRHVTVNGELVNVPSYHLKPGDKVAVREKSKSLEAIDRSLSNSSHVYEWITWNTAQMEGTFVSVPARLQIPENIKEQLIVELYNK
What is the function of this protein?
With S5 and S12 plays an important role in translational accuracy.
What are the official names of this protein?
30S ribosomal protein S4.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS4 family.
Protein: G6PI_ENT38
Sequence: MKNINPTQTSAWQALQKHFDEMKDVSLADLFAKDGDRFSKFSATFDDQMLVDFSKNRITEETLAKLQDLAKETDLAGAIKSMFSGEKINRTEDRAVLHVALRNRSNTPIMVDGKDVMPEVNAVLEKMKTFSEEIISGSWKGYTGKAITDVVNIGIGGSDLGPFMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNPETTLFLVASKTFTTQETMTNAHSARDWFLATAGDNKHVAKHFAALSTNGKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIILSVGYDNFVELLSGAHAMDKHFANTAPEKNLPVLLALIGIWYNNFFGAETEAILPYDQYMHRFAAYFQQGNMESNGKYVDRNGNAVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKMVPCDFIAPATTHNALSDHHQKLLSNFFAQTEALAFGKARDVVEQEYRDLGKDPATLENVVPFKVFEGNRPTNSILLREITPFSLGALIALYEHKIFTQGAILNIFTFDQWGVELGKQLANRILPELGDDKDINSHDSSTNGLINRYKSWRA
What is the function of this protein?
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
What are the official names of this protein?
Glucose-6-phosphate isomerase, GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI.
What is the protein family that this protein belongs to?
Belongs to the GPI family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_EHRRG
Sequence: MIKHNLVSDLRRLFIDFFVKNGHQFFPSSPLIIKDDPSLLFTNAGMVQFKQIFTSVDGRSINTAVSSQKCLRVGGKHNDLENVGHTNRHHTFFEMLGNFSFGSYFKEHAIELAWNFVIKELALDRKRLYITVYHDDQDAFNLWKKISSFSDDKIIKIKTNDNFWSMGNVGPCGPCSEIFYDYGESVKGGLPGTPEEDGARFTEIWNLVFMEYNRTKEGELSVLPRKCIDTGMGLERIAAVMQGVHDNYDINLFKALIAMSKKESGNSSCEIAHRVIADHVRSAAFLIAEGLTPGNEGRDYILRRIIRRAARYVYMLKYTDSLMYKIFPVLIDETSNAYMADYYPELLKAKDMIISILKTEEENFKDTLVRALPLLEKELTYLSAGDVLSGDVIFRLYDTYGFPVDITLDIIKERGIRFDEKGFYDNMEQQKTRSRLSHLIKSTEQLNGKIWEDIRQNYNNTRFVGYDNFQVQSKILSMVMNNDRNVTVANVGDKVSILMDVTPFYAEAGGQQADTGLLSVVRRDGKDLFGSSNIADVTNTKNIFDGLYIHECIIKSGSLIIGDIVSAEINSHRRKDLCANHSATHLLHYILRMEIDNNIMQKGSLVGNDKLRFDFSYNMALTEKQIKLIENRMCDLIRQNHPVETNICNLQDAMDNGAIALFTEKYDNHEVRVVNIGNSKELCCGTHVKYTGEIGCFKIISESSIACGIRRIEAVTGQYAIDYFRQQEKVLYQVAESVKSPVEDVLVQIDKINRENQELKQKLWAAYFDIIDMQGVNIEKIGNINFLHGTLSGVPIDVVRKFIMKRLVKDMIMLFSNVVNHNRIYVVGVGNSLHSKVKAADFVKIINCVVKSKGGGNAQLAQISTEYIAEVNVIQHIKDELVSIFNA
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEOB_ECOSM
Sequence: MKRAFIMVLDSFGIGATEDAERFGDVGADTLGHIAEACAKGEADNGRKGPLNLPNLTRLGLAKAHEGSTGFIPAGMDGNAEVIGAYAWAHEMSSGKDTPSGHWEIAGVPVLFEWGYFSDHENSFPQELLDKLVERANLPGYLGNCHSSGTVILDQLGEEHMKTGKPIFYTSADSVFQIACHEETFGLDKLYELCEIAREELTNGGYNIGRVIARPFIGDKAGNFQRTGNRHDLAVEPPAPTVLQKLVDEKHGQVVSVGKIADIYANCGITKKVKATGLDALFDATIKEMKEAGDNTIVFTNFVDFDSSWGHRRDVAGYAAGLELFDRRLPELMSLLRDDDILILTADHGCDPTWTGTDHTREHIPVLVYGPKVKPGSLGHRETFADIGQTLAKYFGTSDMEYGKAMF
What is the function of this protein?
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
What are the official names of this protein?
Phosphopentomutase, Phosphodeoxyribomutase.
What is the protein family that this protein belongs to?
Belongs to the phosphopentomutase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CDIP1_MOUSE
Sequence: MSNEPPPPYPGGPTAPLLEEKSGAPLTPGRTSPAVMQPPPGMPLPSADIAPPPYEPPGQPVPQPGFVPPHMNADGTYMPAGFYPPPGPHPPMGYYPPGPYPPGPYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYICTYKRLC
What is the function of this protein?
Acts as an important p53/TP53-apoptotic effector.  Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner (By similarity).
What are the official names of this protein?
Cell death-inducing p53-target protein 1, LITAF-like protein.
What is the protein family that this protein belongs to?
Belongs to the CDIP1/LITAF family.
What are the subcellular locations of this protein?
Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: O261_CONTE
Sequence: MEKLTILLLVAVVLMSTQALPQGGGEKRPRENIRFLSKRKSNAERWREGSCTSWLATCTDASQCCTGVCYKRAYCALWE
What are the official names of this protein?
Conotoxin TxMEKL-021, Conotoxin TxMEKL-022.
What is the protein family that this protein belongs to?
Belongs to the conotoxin O2 superfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: RUVB_STRT2
Sequence: MARILDNDLLGDEEYVERTLRPQYFKEYIGQDKVKDQLKIFIEAAKLRDEALDHTLLFGPPGLGKTTMAFVIANEMGVNLKQTSGPAIEKAGDLVAILNDLEPGDILFIDEIHRMPMAVEEVLYSAMEDYYIDIMIGAGETSRSVHLDLPPFTLVGATTRAGMLSNPLRARFGINGHMEYYELPDLTEIVERTSEIFEMTITPEAALELARRSRGTPRIANRLLKRVRDYAQIMGDGVIDDKIADQALTMLDVDHEGLDYVDQKILRTMIEMYGGGPVGLGTLSVNIAEERETVEDMYEPYLIQKGFIMRTRTGRVATAKAYEHMGYDYTRDN
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR) (By similarity).  Catalyzes branch migration on Holliday junction (HJ) DNA in complex with RuvA from S. typhimurim and ATP (PubMed:36002576).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  Forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle forms the mechanistic basis for DNA recombination by continuous branch migration (PubMed:36002576).  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA (By similarity).
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MTPN_CANLF
Sequence: MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ
What is the function of this protein?
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity.  Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation.  Promotes cardiac muscle hypertrophy.  Plays a role in the regulation of the growth of actin filaments.  Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer (By similarity).
What are the official names of this protein?
Myotrophin.
What is the protein family that this protein belongs to?
Belongs to the myotrophin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
Protein: PSD_PSEPW
Sequence: MKSRLFIISQYLLPHHLLSRLAGCVAECRARWFKNAFTAWFAKRYQVNMNEALVEDLTAYEHFNAFFTRALKPDARPLDETPGAILCPADGAVSQLGPIEHGRIFQAKGHSFSALELLGGDPALAAPFMGGEFATIYLSPKDYHRVHMPLAGTLREMVYVPGRLFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASIETVWAGLVTPPKRELKTFRYDEGSRAPIHLEKGAELGRFKLGSTAIVLFGPEQVKWAETLGAGSATRMGELLAVPVQA
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: A85B_MYCLE
Sequence: MIDVSGKIRAWGRWLLVGAAATLPSLISLAGGAATASAFSRPGLPVEYLQVPSEAMGRSIKVQFQNGGNGSPAVYLLDGLRAQDDYNGWDINTSAFEWYYQSGLSVVMPVGGQSSFYSDWYSPACGKAGCTTYKWETFLTSELPKWLSANRSVKSTGSAVVGLSMAGSSALILAAYHPDQFIYAGSLSALMDSSQGIEPQLIGLAMGDAGGYKAADMWGPPNDPAWQRNDPILQAGKLVANNTHLWVYCGNGTPSELGGTNVPAEFLENFVHGSNLKFQDAYNGAGGHNAVFNLNADGTHSWEYWGAQLNAMKPDLQNTLMAVPRSG
What is the function of this protein?
The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M. tuberculosis to murine alveolar macrophages (AMs).  They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor).  They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM (By similarity).
What are the official names of this protein?
Diacylglycerol acyltransferase/mycolyltransferase Ag85B, DGAT, 30 kDa extracellular protein, Acyl-CoA:diacylglycerol acyltransferase, Antigen 85 complex B, 85B, Ag85B, Extracellular alpha-antigen, Fibronectin-binding protein B, Fbps B.
What is the protein family that this protein belongs to?
Belongs to the mycobacterial A85 antigen family.
What are the subcellular locations of this protein?
Secreted.
Protein: TILS_CHLVU
Sequence: MKKDSTIISTCNEFSLSSVKTKRVYKNNHLLCSVSGGQDSIVSFFFLVNFLYLSKNFKLIKSKLSSFSVASKSAEKKRCFDCFFSLKKNKKINALINKEKKLSRLDLVFCQHFWQTQNFFCVEFLFQLTFFFDIPYTFVLSKNILVSENRARGWRKKTFSRLLKIQKLSTIVTGQTKTDTAEKSITNLLRGTSPKSFSLITKANSKTTSSFFCFRLFRPKTFYLTLTGNKRERKVNRRISFSFYRTQKKDSKKLRETRAPFFIEMASFSAFFGNTFQKKKSSNSFLLYKTRLSFSFCFSGETREHSINSLKPLQNRNRYHISKLVKFYKFPLTIDATNFSLNFSRNKIRHLFIPFIRFLFKLKFETLLLNFLYLVNLEHEQIENENLELKRVLNFLRINYLKKNFFSSNRRSFFVIQTGHKNNNVFPTKKKEKRWFYCNEIGISKIRKQCKIHEDPILETSLVIYFTSVLTTSRKYSLLQNLLYNYREIEINFRQISKLENSFW
What is the function of this protein?
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner.  Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
What are the official names of this protein?
tRNA(Ile)-lysidine synthase, chloroplastic, tRNA(Ile)-2-lysyl-cytidine synthase, tRNA(Ile)-lysidine synthetase.
What is the protein family that this protein belongs to?
Belongs to the tRNA(Ile)-lysidine synthase family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: AGRA_STAAN
Sequence: MKIFICEDDPKQRENMVTIIKNYIMIEEKPMEIALATDNPYEVLEQAKNMNDIGCYFLDIQLSTDINGIKLGSEIRKHDPVGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPAELRTRIIDCLETAHTRLQLLSKDNSVETIELKRGSNSVYVQYDDIMFFESSTKSHRLIAHLDNRQIEFYGNLKELSQLDDRFFRCHNSFVVNRHNIESIDSKERIVYFKNKEHCYASVRNVKKI
What is the function of this protein?
Required for high-level post-exponential phase expression of a series of secreted proteins.
What are the official names of this protein?
Accessory gene regulator protein A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AROE_SALCH
Sequence: METYAVFGNPIAHSKSPFIHQQFAQQLDIVHPYGRVLAPINNFINTLDAFFAAGGKGANITVPFKEEAFARSDELTERASLAGAVNTLKRLEDGRLLGDNTDGIGLLSDLKRLNFIRPGWRILLIGAGGASRGVLLPLLSLDCAVTITNRTASRAEALAKIFAHTGSVHATDMDKLDGCEFDLIVNATSSGIRGEIPAIPASLIHPSLCCYDMFYQKGNTPFLSWCVQQGAKRYADGLGMLVGQAAHAVLLWHGVLPQVEPVIKLLQQELLA
What is the function of this protein?
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids.  Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
What are the official names of this protein?
Shikimate dehydrogenase (NADP(+)), SDH.
What is the protein family that this protein belongs to?
Belongs to the shikimate dehydrogenase family.
Protein: SRSF3_HUMAN
Sequence: MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK
What is the function of this protein?
Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937).  Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937).  Also functions as export adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244).  Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396).  Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244).  RNA-binding is semi-sequence specific (PubMed:17036044).
What are the official names of this protein?
Serine/arginine-rich splicing factor 3, Pre-mRNA-splicing factor SRP20, Splicing factor, arginine/serine-rich 3.
What is the protein family that this protein belongs to?
Belongs to the splicing factor SR family.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle. Cytoplasm. Note=Recruited to nuclear speckles following interaction with YTHDC1.
Protein: XERD_RHIME
Sequence: MTDMSAAYVEAFLEMMSAERGAAANTLQSYERDLEDARSFLRSRGTGLTDASADDLRSYLSHLAGQGFKASSQARRLSALRQFYKFLYAEGLRTDDPTGILDAPKKARTLPKTLSIEDVTRLIGQAEAEAKSGSDDVMAKLRMHALIELLYATGMRVSELVSLPASVLAQNGRFLIIRGKGNKERLVPLSQAAIRAMRAYGEALQEESADSPWLFPSNGKSGHLPRQVFARDLKSLAARAGIRVAAISPHVLRHAFASHLLANGADLRAVQELLGHSDISTTQIYTHVLEERLHDLVQNHHPLAKQAKKQD
What is the function of this protein?
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.  The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.  It also contributes to the segregational stability of plasmids.
What are the official names of this protein?
Tyrosine recombinase XerD.
What is the protein family that this protein belongs to?
Belongs to the 'phage' integrase family. XerD subfamily.
What are the subcellular locations of this protein?
Cytoplasm.