PharMolix/UniProtQA huggingface dataset:
Protein: CIART_MOUSE
Sequence: MDSPSSVSSYSSSSLSPSFSTSSVNSDFSFPSDNEREGKGTHELRPDTVGQRGGSRPSPGPIRCRHRPRVSSNQHTAPHLEQQGSEVKRSRDGEQETSLNTQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFDRGLSSFQQSVAMDRIQRIVGVLQKPQMGERYLGTLLQVEGMLKTWFPHIAAQKSSSGGSRHQISKHFPSHHGDPGAASPAPLLEKMGQTQLGHLVLKPKQPWHLTGWPAMNLTWIHSTPICNPPLSSQGSASGHSPIGTGASIGVILVLQKGGQPFTHSAPGTPVPPTPLSPVVPGDLKKLPGEEPRCHSLPVTLPSDWSCILCPPVLPTTDREMTKGHPEPQMTSHPPVAPDPQP
What is the function of this protein?
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41.  In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.  Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes.  Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1.  Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response.
What are the official names of this protein?
Circadian-associated transcriptional repressor, ChIP-derived repressor of network oscillator, Chrono, Computationally highlighted repressor of the network oscillator.
What are the subcellular locations of this protein?
Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body.
Protein: URED_AZOSB
Sequence: MNAVSDLRALHAAQPGWQAALSLGFERRGARTVLATRRHVGPLVVQRALYPEGDGVCHAIVVHPPAGIVGGDALRIDVDLGAGAHALLTTPGAGKWYRSAGARGSLVQRIAVGDGAVCEWLPQESIVYDGAAGDLATEVDIAGDGVFIGSEMTCFGRSGAGERYTRGDFAMRTRIRRDGRTLWLERGRVEGGGALLDSPVGLAGWPVTATLLVAAKTVDAALLEACREVPAEAGEGAATLLPGLLVARYRGPACEPGRNWFNRLWTLLRPPLAGRAATLPRIWHT
What is the function of this protein?
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
What are the official names of this protein?
Urease accessory protein UreD.
What is the protein family that this protein belongs to?
Belongs to the UreD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SECA_FRATN
Sequence: MLSLVQKIIGSRNERFIKKVSRIVQKINSLEPEFEKLSDEQLKAKTFEYRERLANGEILDNLLPEAFATVREAGKRTKNMRHYDVQLIGGIVLHQGKVAEMRTGEGKTLVATLPAYLNALTGDGVHVITVNDYLAKRDAELMSDIYEFLGMSVGVIVADLNPQQRKEAYACDITYGTNNEFGFDYLRDNMAYEKEQQVQRSRNYVIIDEVDSILIDEARTPLIISGASDDSSEMYNLFNRLVPYLEKQEKEEVENEQEQRDFYVDEKSKNAYLTEKGYAKIENMLKKEGILEEDDNLYSPHNITKMHYLNACLRAHSLYQLNIDYIVRDQEIVIIDESTGRAMPGRRWSDGLHQAIEAKEGVKINAENQTMASITFQNFFKLYNKIAGMTGTADTEAFELHSIYGLEVIIIPTNKPMIRKDHHDEIYGSVREKFDAIVEDIKERISKGQPVLVGTASIEASEVLSTLLKKKKIRHNVLNAKQHEKEASIIAMAGYPGNVTIATNMAGRGTDIILGGNLEVEIAQLEDPTPEDIAQIKAEWLKRNEAVKKAGGLCIIGSERHDSRRIDNQLRGRAARQGDPGESKFYLSMDDNLLRIFASQSMAERVKKGLKGGESLAFGFMSKVISKAQGKVESYHFDIRKNLLEYDNVVNTQRKVIYEQRQSFLEAEDVSDILADIRIDVAEQLFHDYVPAGSMHELWDLEGLEKALKSDFMIELDLQKLYQEDDSLGEEDLKKLVREAIEIEFVEKTKNLDSGAVRQFEKFSLLQSLDTHWREHLSSIDHLRNSINLRGYAQKDPKNEYKKEAFELFSTMLDNFKYEVISSLAKIRIATEEETQRAQQEWQESMSDIKAEHESVIDNNQRHDEDEQEETPKVQQVRREGPKVKRNDPCPCGSGKKYKQCHGKVE
What is the function of this protein?
Part of the Sec protein translocase complex.  Interacts with the SecYEG preprotein conducting channel.  Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
What are the official names of this protein?
Protein translocase subunit SecA.
What is the protein family that this protein belongs to?
Belongs to the SecA family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50- 50.
Protein: CU1A_CONLO
Sequence: LFHYCQCQCPPGFKGKFCQFKLRPP
What is the function of this protein?
Peptide with nanomolar affinity for human melanocortin receptors.  The natural disulfide pairing being unknown, the activity of all three possible peptides (with the cysteine pairings 'bead (I-II, III-IV), 'globular' (I-III, II-IV), and 'ribbon' (I-IV, II-III)) have been tested.  All three isomers show similar affinities on each human melanocortin subtype (MC1R (~500 nM), MC3R (~100 nM), MC4R (~50 nM), and MC5R (~50 nM)).
What are the official names of this protein?
NU-conotoxin-Ltg1a, NU-CTX-Ltg1a, N-CTX-Ltg1a.
Protein: RIMM_ACICJ
Sequence: MDDRLILMGVIGRPHGVRGAVHVTTYSPDPEGLAELPLRDERGRRVGLAWTGAGIARVTIGEGDEAAAIADRDAAAKLTNLRLYVRRADLPPPEDEDEFYFADLIGLHAVGPDGAALGTIRAVHDFGAGASIELSDGSLLPFTRAVVPEIDLPGGRAVVVRPVEVEMRE
What is the function of this protein?
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region.  Probably interacts with S19.  Essential for efficient processing of 16S rRNA.  May be needed both before and after RbfA during the maturation of 16S rRNA.  It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
What are the official names of this protein?
Ribosome maturation factor RimM.
What is the protein family that this protein belongs to?
Belongs to the RimM family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NSH5_ARATH
Sequence: MLSPRRFILVVTILGLLGHNLTHVLNSPHRILLDTDVDTDDFIALLYLLKLNKTEFDLVGITLSANSWTNAGHGVNHIYDILYMMGRDDITVGVGGEGGILEDGTILPDVGDYLPIIEQGMTTAGGCRYRQSIPKGRIQKIDSNYGFRKHFLPQGNRRYTPLEQPTAQKVIVDKVSEGPISIFVIGSHTNLALFMMSNPHLKHNIQHIYVMGGSVRCQNPNGFCGNLFTDYTSNPYAEFNIFTDPFAAYQVFRLLWFL
What is the function of this protein?
May be involved in the degradation of extracellular nucleosides.
What are the official names of this protein?
Nucleoside hydrolase 5.
What is the protein family that this protein belongs to?
Belongs to the IUNH family.
What are the subcellular locations of this protein?
Secreted, extracellular space, apoplast. Note=Present in the apoplastic fluid.
Protein: SUCC_SHEPC
Sequence: MNLHEYQAKSLFAEYGLPVSEGFACDTAQEAVEAAGRIGGNLWVVKCQVHAGGRGKAGGVKVTGDKEEIRAFAEHWLGKNLVTYQTDEKGQPVAKILVESCTDIANELYLGAVVDRSTRRVVFMASTEGGVEIEKVAEETPELIHKAIIDPLTGPQPYQARDLGFKLGLNPTQMKQFTKIFMGLATMFVDHDFALLEINPLVITTEGNLHCLDGKIGIDGNALFRQPKVKAMHDPSQDDAREAHAAMFELNYVALDGNVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGATKERVAEAFKIILSDSNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVKVPVVVRLEGTNAELGREVLAKSGLDIIAATSLTDAAERVVKAAEGK
What is the function of this protein?
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA.  The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
What are the official names of this protein?
Succinate--CoA ligase [ADP-forming] subunit beta, Succinyl-CoA synthetase subunit beta, SCS-beta.
What is the protein family that this protein belongs to?
Belongs to the succinate/malate CoA ligase beta subunit family.
Protein: PNP_EXISA
Sequence: MLGTKQVFSTEWGGRPLSVEVGQLAKQANGSALVRYGDTVVLATVTASKAPKDLDFFPLTVNYEEKLYSVGKIPGGFLRREGRPGENAILTSRLIDRPIRPLFPDGFRHDIQVMIYVMSNDPDCSAEMAGMLGTSIALSISDVPFDGPIAGVTVGRVDGEFVINPTTAQLEKTDLELQVAGTSTAINMVEAGANEVPEDVMLESILFGHEEIKRLIAFQQEIVEAVGKPKFEYTVSKYDEALTAELEAARPEIVEAVQVEEKHARDEAINEVIAKYVAMYEARLADEPSKLGEVSGILNKFVKDEVRRLITVEKVRPDGRRPDVIRPLASEVGLLPRAHGVGLFTRGQTQVMSVATLGVIGDAQIIDGIGLEENKRFMHHYNFPPFSVGEARPVRAPGRREIGHGALGERALLPIIPKEADFPYTIRLVSEVLESNGSSSQASICGSTLALMDAGVPIKAPVAGIAMGLIMEGEHYTVLTDIQGLEDHLGDMDFKVAGTKDGITALQMDIKIAGITREILEEALEQARVGRLHILDHMLETLETPRTQLSKYAPKIVTMTINPDKIRDVIGPGGKMINSIIDQTGVKIDIEQDGTVFIASTDQEGIDLAMSMIGDIVREVVVGEVYDATVRRIEKFGAFVELFKGKDALVHVSEFSLERVANVEDVVKLGDSIQVKVTEIDDKGRVNASRKALILEGLSPEEREAYEAKRKAARESRPPRDSRPPRRDGDRRPPRSTN
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: UPP_DESHD
Sequence: MAKVHILDHPLIQHKLSLIRDENTGSKDFRELVEEVSMLMAYEVTRDFPLQDVEVKTPVATMTAKAIAGRKVGLIPILRAGLGMVDGMLRLIPTAKVGHVGLYRDPETLKPVEYYCKLPTDVEERDLIVIDPMLATGGSATAAITFLKDRGAKSIKLMCLIAAPEGIKEVQNYHDDVDIFVAAVDDYLNDHGYIIPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: RL24_STRA1
Sequence: MFVKKGDKVRVIAGKDKGTEAVVLKALPKVNKVVVEGVALIKKHQKPNNENPQGAIVEKEAPIHVSNVQVLDKNGVAGRVGYKVVDGKKVRYNKKSGEVLD
What is the function of this protein?
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
What are the official names of this protein?
50S ribosomal protein L24.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL24 family.
Protein: VP35_MABVO
Sequence: MWDSSYMQQVSEGLMTGKVPIDQVFGANPLEKLYKRRKPKGTVGLQCSPCLMSKATSTDDIIWDQLIVKKTLADLLIPINRQISDIQSTLSEVTTRVHEIERQLHEITPVLKMGRTLEAISKGMSEMLAKYDHLVISTGRTTAPAAAFDAYLNEHGVPPPQPAIFKDLGVAQQACSKGTMVKNATTDAADKMSKVLELSEETFSKPNLSAKDLALLLFTHLPGNNTPFHILAQVLSKIAYKSGKSGAFLDAFHQILSEGENAQAALTRLSRTFDAFLGVVPPVIRVKNFQTVPRPCQKSLRAVPPNPTIDKGWVCVYSSEQGETRALKI
What is the function of this protein?
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
What are the official names of this protein?
Polymerase cofactor VP35, Marburg VP35, mVP35.
What is the protein family that this protein belongs to?
Belongs to the filoviridae polymerase cofactor VP35 family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: YEH5_SCHPO
Sequence: MLLHGLGRMNIIFICFPSLACLLTSRTPLCAPLFSHLDGMTPCPIDCGFAVGRSRGGGFGGKPESNSLHYDTMHKQHAMPFFIINPTEWKRNFCNTG
What are the official names of this protein?
Uncharacterized protein C23H4.05c.
Protein: SHE3_CANTT
Sequence: MPDTPVSPSKNNVKTSSTPVSSSTKVIDSLHSKIDELTDELTTLKQSHQELTKKHSIVAKKNDSFVDQLANAKHENDMLSALLKRKERRILDLEDQYNDLNSQIENLSLSNKNMKIRCENLQNNSNASIAEFERLKISYDALIASQMEYKNHYQQELNTLQTSFDKYRTENTKRYEDLQSSISSNDKDIDTLLDSLTNKRKTMDNIYVNKNNKILQLLTSLASLIKLHAEDTKGQVEQNVDVIKILMEKYPDLQEKILEKEKVEVDLDEIISHSNEILANTSFEEDATLINSPDLDSQSNLNSGAATPVQNSGPFRKKKNYKRNSMILKDSPSGIPENSVPSSLPKKPQVNNNIINIPKNRSKFNTPPTTPRQFSNQSTDFEVTHQWNGNNNQHNNSGHYNNNNHRRTTSYDARSDNGGNRRQHSQGSNYNNNNNNNNNNNNGFVRRSGSVRNGSNNNNNNNHGKQAKRRSTYNPNNNSKRNSQIFDSNFALNV
What is the function of this protein?
RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease.  Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell.  Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity).
What are the official names of this protein?
SWI5-dependent HO expression protein 3.
What is the protein family that this protein belongs to?
Belongs to the SHE3 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein.
Protein: NADD_GEOSM
Sequence: MRLGILGGTFNPIHNAHLRIAEEARDLYELDRVVFIPAATPPHKPLVGELSFASRLEMVRLAVADNSGFMVSDMEGVRGGRSYSIDTLRELKAEHPDDELFFIVGADSFNDISTWKEYAAIFGLCNVISVQRPGSTITSLAEVLPVAIAGEFCYDPAANRLNHCSGHAVYALDGVLLDISSSHIRLLVQGGRSIRYLIPDAVEQYIKEQRLYVDAR
What is the function of this protein?
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
What are the official names of this protein?
Probable nicotinate-nucleotide adenylyltransferase, Deamido-NAD(+) diphosphorylase, Deamido-NAD(+) pyrophosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase.
What is the protein family that this protein belongs to?
Belongs to the NadD family.
Protein: ZFP41_HUMAN
Sequence: MEKPAGRKKKTPTPREEADVQKSALREEKVSGDRKPPERPTVPRKPRTEPCLSPEDEEHVFDAFDASFKDDFEGVPVFIPFQRKKPYECSECGRIFKHKTDHIRHQRVHTGEKPFKCAQCGKAFRHSSDVTKHQRTHTGEKPFKCGECGKAFNCGSNLLKHQKTHTGEKPYECTHCGKAFAYSSCLIRHQKRHPRKKP
What is the function of this protein?
A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.
What are the official names of this protein?
Zinc finger protein 41 homolog, Zfp-41.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: DXR_PSEF5
Sequence: MTAVQQITVLGATGSIGLSTLDVIARHPDRYQVFALTGFTRLAELLALCVKHEPRFAVVPEAAAASRLQQDLRGAGLATQVLVGEQGLCEVASAPEVDAVMAAIVGAAGLRPTLAAVEAGKKILLANKEALVMSGALFMQAVGKSGSVLLPIDSEHNAIFQCMPADFSRGLSRVGVRRILLTASGGPFRQTPLEELEHVSPEQACAHPNWSMGRKISVDSASMMNKGLELIEACWLFDARPSQVEVVVHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPERIDSGVAPLDLFAIARLDFQAPDEQRFPCLRLARQAAEAGNSAPAMLNAANEVAVSAFLERRIRYPEIASIIDEVLTREPVVAVNELDAVFAADARARVLAQQWLQRNGR
What is the function of this protein?
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
What are the official names of this protein?
1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase.
What is the protein family that this protein belongs to?
Belongs to the DXR family.
Protein: RL36_GRABC
Sequence: MKIRNSLKSAKVRDKNCRVVRRHGRVYVINKKNPRMKARQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: APT_MYXXD
Sequence: MHPPVPSLTDTTLVADLNARLRDVPDFPKPGIVFKDITPVLADPRLFGRVIDAMSAPFRGQHVTKVVGVEARGFLLGAPIALALNAGFVPARKPGKLPHRSVVERYSLEYGSDGVEMHEDAILQGERVLVVDDVLATGGTAEATARLVSRLGGELVGFCFLLSLDFLEGPNRLGRERVTTLLTF
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MMP3_HUMAN
Sequence: MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
What is the function of this protein?
Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans.  Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9 (PubMed:11029580, PubMed:1371271).  Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway (PubMed:2383557).  Acts also intracellularly (PubMed:22265821).  For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:21330369).  In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1 (PubMed:35940311).  Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311).
What are the official names of this protein?
Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3, Transin-1.
What is the protein family that this protein belongs to?
Belongs to the peptidase M10A family.
What are the subcellular locations of this protein?
Secreted, extracellular space, extracellular matrix.
Protein: THIG_BACLD
Sequence: MLKIADRQFSSRLLLGTGKYPSFEIQKEAVSASESEILTFAVRRMNIFEESQPNFLEQLDLSRYTLLPNTAGAKTAEEAVRIAKLAKASGLCDMIKVEVIGCDRSLLPDPVETLKASETLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGSGQGIINPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGAKDPVQMAKAMKFAVEAGRLGYLAGRIPEKNYGIASSPEEGKLTI
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS1_NEIMB
Sequence: MQDNALTIALSKGRIFEETLPLLAAAGIVPTEEPEKSRKLIIGTNHENIRLVIVRATDVPTYVRYGAADFGIAGKDVLIEHGGTGLYRPLDLEIAKCRMMVAVRKGFDYEAASQPGCRLKIATKYPEIAASHFAGKGVHVDIIKLYGSMELAPLVGLSDAIVDLVSTGNTLKANGLEAVEHIVDISSRLVVNKAALKTKYALLEPIIQAFGGAVKAK
What is the function of this protein?
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP).  Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
What are the official names of this protein?
ATP phosphoribosyltransferase, ATP-PRT, ATP-PRTase.
What is the protein family that this protein belongs to?
Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSPQ_SHIFL
Sequence: MIASKFGIGQQVRHSLLGYLGVVVDIDPVYSLSEPSPDELAVNDELRAAPWYHVVMEDDNGLPVHTYLAEAQLSSELQDEHPEQPSMDELAQTIRKQLQAPRLRN
What is the function of this protein?
Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
What are the official names of this protein?
Heat shock protein HspQ.
What is the protein family that this protein belongs to?
Belongs to the HspQ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLND_PSEPG
Sequence: MPQVDPELFDRGQFQAELALKASPIAAFKKAIRLAGEVLDKRFRAGSEIRPLIEARAWLVDNILQQAWNQFDWGDQSGIALVAVGGYGRGELHPHSDIDLLILLGAAEHEQYRDAIERFLTLLWDIGLEVGQSVRTVDECAEQARADLTVITNLMESRTICGPEALRQRMLEVTSTAHMWPSKEFFLAKRAELKARHHKYNDTEYNLEPNVKGSPGGLRDIQTVLWVARRQYGTLNLHALAGEGFLLESENELLASSQDFLWKVRYALHMLAGRAEDRLLFDHQRSLATLLGYGDDNPKRAIEQFMQQYYRVVMSISQLCDLIVQHFEEVILADEESGSTQPLNARFRLHDGYIEAANPNVFKRTPFAMLEIFVLMAQRPEIKGVRADTVRLLREHRHLIDDTFRTDIRNTSLFIELFKCEIGIHRNLRRMNRYGILGRYLPEFGLIVGQMQHDLFHIYTVDAHTLNLIKHLRKLQYTPVSEKFPLASKLMGRLPKPELIYLAGLYHDIGKGRQGDHSEIGAVDAQKFCERHQLPAWDSRLIVWLVQNHLVMSTTAQRKDLSDPQVINDFALHVGDETRLDYLYVLTVADINATNPSLWNSWRASLLRQLYTETKRALRRGLENPLDREEQIRQTQSSALDILVREGTDPDDVEQLWSQLGDDYFLKHNAADVAWHTDAILQQPADGGPLVLIKETTQREFEGGTQIFIYAPDQHDFFAVTVAAMSQLNLNIHDARIITSSSQFTLDTYIVLDNDGGSIGDNPQRVKQIRDGLTEALRNPEDYPTIIQRRVPRQLKHFDFPPQVTILNDAQRPVTILEITAPDRPGLLARLGRIFLEFDLSLQNAKIATLGERVEDVFFITDADNQPLSDPQLCSRLQEAIVQQLQAGQGSDTSPTRVTF
What is the function of this protein?
Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level.  Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation).  Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
What are the official names of this protein?
Bifunctional uridylyltransferase/uridylyl-removing enzyme, UTase/UR, Bifunctional [protein-PII] modification enzyme, Bifunctional nitrogen sensor protein.
What is the protein family that this protein belongs to?
Belongs to the GlnD family.
Protein: Y067_OSHVF
Sequence: MRLRSQKRGNKFVALPAKTRKGKGKKLKPKNLTITKKDEVKKIKKTITPKPNNIDEDDGIGEVDDIMDITPNYQGNNDGNELDLQQTPIIPNEIKDLFMGDNWRKISGPHAVSIITKPQHRRYIALKGTMGTGKTHVTVESLNKITGSTGSILLIVGRKELANEIERRINGSCKVYNYLEKEEFSNGISLSRGGLLTERCVFIVCVNSITTDLFKEDGFKTDMIVVDEVETTFMNIVSESLMTYSAAIETRNTLVEKLFPYTNVLLTIDAALAEPMVVGCAKMFGGKFEEYKLDLVRIRPPIYHRAVQCSTAYNIIDHNPLEKRYDTLFNAITYHVYELGKRIVISVPYHKTALQLKRHILAARPQHFHKIPHVVVYTAKTRDARLARIKALQTGEQYGIEALAKEADVFIFNSCMSAGHSLNMDGYEACFSYFLINHMTCSVMEQLQMTARLRNNNSKTLYWGLMNTMNDPLRGIRDIEELKTYSTMMRKFGKWMGSSFDNGIKGFKILLKMAYPNIVFEKGVVKSREYPYKNNEIINQTMQNDASVLRKLFINPEPSKWRFVTQEHEALYGKDLPPRQFNYYSTLSGLYNVVLS
What are the official names of this protein?
Uncharacterized protein ORF67.
Protein: ARGR_HAEI8
Sequence: MTDNLTRAFKELLNQERFGSQNEIVDALKKQGFTGINQSKISRMLSKFGAVRTRNTKMEMVYCLPNELSVPNTSSPLKNLVLDVDHNSMLIVIKTTPGAAQLIARLLDSIGKSEGILGTIAGDDTIFVTPTNDKPIAELLQNIQRLFENAL
What is the function of this protein?
Regulates arginine biosynthesis genes.
What are the official names of this protein?
Arginine repressor.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y056_SIFVH
Sequence: MSFLLNLGQAFFSGLSSIATGVTSDVTSVANGINYAFNVLANFLQKLPSEIATFFQSIPGALIGFAHTFGTYIWDGMQRIASGFTAIMAPIERGLETLGTTVINALTVVWNDIKAFASAIYNSIVSMINNIVSFVQPFINDFKNAISFAYNFLLNVINDVYSAFTIISNFFLDLPTFFQNASNYLNSLFTDPGNQPNLLTMVPNLVASEVSRIAGAFPDVIAYNTFMEVLPKMVSGIASSPIFGNTVKGMFAKALLMAGSPILSALLSELTKALMQSLFTSTQTTQTTQRPSQPQIQPPTAPSTQLQQRSTQQTSLSDLQNLQTQQLTPTQIEVQLERPNVTGVFTQDVIGMGTASGGTAKLVTGYINFQNSIKQFEDVFNITASFFMELIQSLQTEFSQDMAVNVSLTLLENIYQVSQSIEIIPSVDATTIILPPGISLCNPSQAPSPSESTSTSTNSIDVTTTVDVTEELCIPPYDLLADGLTTQFAVIALLHSNISDVMLAITQLIYGITFSNLISDILSATTQLMYSITSNISTSDTVSVSASFTPSPPPSETYTYYVPIDIAVTYTIQVASSTTYSGALSYTVSTS
What are the official names of this protein?
Uncharacterized protein 56.
Protein: FABA_PSEA6
Sequence: MTINQDSFTKEELLACSRGELFGPGNSQLPAPNMLMMDRIVKISEEDGEHGKGVIIAELDITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLGWCGGPGKGRALGVGEVKFSGQILPTAKKVTYKIDMKRVIKRKLFMGIGDGEVSVDGRVIYQAKDLKVGLFQDTSNF
What is the function of this protein?
Necessary for the introduction of cis unsaturation into fatty acids.  Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP.  Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
What are the official names of this protein?
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA, Beta-hydroxydecanoyl thioester dehydrase, Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: JANB_DROSE
Sequence: MKMLKSLSLIPRIVSPFQKCYSTDLISLVGVPRVKISKGQNRYLLVNIHTHGFTKYGRVIVRGADVDNHLAIFDSILEELEPEGICAKILGGGRILNEPDNKKIKIYGTSRTFGGADHTRTRNILQAWTTYKDFKITVKQ
What is the function of this protein?
JanA and janB regulate somatic sex differentiation.
What are the official names of this protein?
Sex-regulated protein janus-B.
What is the protein family that this protein belongs to?
Belongs to the janus family.