PharMolix/UniProtQA huggingface dataset:
Protein: CXE1_ARATH
Sequence: MDSEIAFDYSPRFRIFKNGGIERLVPETFVPPSLNPENGVVSKDAVYSPEKNLSLRIYLPQNSVYETGEKKIPLLVYFHGGGFIMETAFSPIYHTFLTSAVSATDCIAVSVEYRRAPEHPIPTLYEDSWDAIQWIFTHITRSGPEDWLNKHADFSKVFLAGDSAGANIAHHMAIRVDKEKLPPENFKISGMILFHPYFLSKALIEEMEVEAMRYYERLWRIASPDSGNGVEDPWINVVGSDLTGLGCRRVLVMVAGNDVLARGGWSYVAELEKSGWIGKVKVMETKEEGHVFHLRDPDSENARRVLRNFAEFLKEETF
What is the function of this protein?
Carboxylesterase acting on esters with varying acyl chain length.
What are the official names of this protein?
Probable carboxylesterase 1, AtCXE1.
What is the protein family that this protein belongs to?
Belongs to the 'GDXG' lipolytic enzyme family.
Protein: MYC4_ARATH
Sequence: MSPTNVQVTDYHLNQSKTDTTNLWSTDDDASVMEAFIGGGSDHSSLFPPLPPPPLPQVNEDNLQQRLQALIEGANENWTYAVFWQSSHGFAGEDNNNNNTVLLGWGDGYYKGEEEKSRKKKSNPASAAEQEHRKRVIRELNSLISGGVGGGDEAGDEEVTDTEWFFLVSMTQSFVKGTGLPGQAFSNSDTIWLSGSNALAGSSCERARQGQIYGLQTMVCVATENGVVELGSSEIIHQSSDLVDKVDTFFNFNNGGGEFGSWAFNLNPDQGENDPGLWISEPNGVDSGLVAAPVMNNGGNDSTSNSDSQPISKLCNGSSVENPNPKVLKSCEMVNFKNGIENGQEEDSSNKKRSPVSNNEEGMLSFTSVLPCDSNHSDLEASVAKEAESNRVVVEPEKKPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYSLRAVVPNVSKMDKASLLGDAISYISELKSKLQKAESDKEELQKQIDVMNKEAGNAKSSVKDRKCLNQESSVLIEMEVDVKIIGWDAMIRIQCSKRNHPGAKFMEALKELDLEVNHASLSVVNDLMIQQATVKMGNQFFTQDQLKVALTEKVGECP
What is the function of this protein?
Transcription factor involved in jasmonic acid (JA) gene regulation.  With MYC2 and MYC3, controls additively subsets of JA-dependent responses.  Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis.  Binds to the G-box (5'-CACGTG-3') of promoters.  Activates multiple TIFY/JAZ promoters.
What are the official names of this protein?
Transcription factor MYC4, AtMYC4, Basic helix-loop-helix protein 4, AtbHLH4, bHLH 4, Transcription factor EN 37, bHLH transcription factor bHLH004.
What are the subcellular locations of this protein?
Nucleus.
Protein: TKN4_RAT
Sequence: MLPLLALFLLIGPAVSTTTRDREDLTFGAEAESWVTVNLKGIPVPSIELKLQELKRSRTRQFYGLMGKRVEGVHPIQSAERTGYQLGRIVQDLLGTRGLSIEGSCRQETNHQSAGPGAVARESLQSQRGRSEPPNHQQHVALSLGTEEDDQSSERAPRDASQMMPRPSRP
What is the function of this protein?
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.  Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior.  Increases sperm motility.  Induces potent analgesic effects and may play a role in pain modulation.  Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation.  Lowers systemic arterial pressure following intravenous injection.  Induces interferon-gamma production and may play a role in the inflammatory response.  Shows potent affinity and specificity for the NK-1 receptor.
What are the official names of this protein?
Tachykinin-4, Preprotachykinin-C, PPT-C.
What is the protein family that this protein belongs to?
Belongs to the tachykinin family.
What are the subcellular locations of this protein?
Secreted.
Protein: HMDH2_ASPFU
Sequence: MAPTNTKDSDTPGWLHRHGTSVLGSVARQACKQPIYTLVITALLATMTYTSLLEGSLYNANLTRLSNSHLNQLDVTDFLQGSRSLRLGKATAWQWETDDESMSDQEVRPSFFLDPVASHLALITLVFPTSENNPGISAVQESIISDLAAAQLVSRTPSVLSSTFRETSITLSVPYNNLEEVLRKTQNFPQPEAEHSWTLKNAGKCNSGPKLRLWLIDVLASFVGLIKHAQIIDIIIMLLAYLAMHLTFLSLFMSMRQLGSRFWLAYSVLLSGFFSLFFGLKVTTSSGVSTSMITLSECLPILVIIVGFEKPIRLTRAVLRAATESYLPAKPMARRSTPEAIEVAIMREGWRIVRDYAIEIAILAAGATSRVQGALPQFCFLAAWILLFDSLLLFTFYISVLCVKLEITRIRKHVEPRRALEDDDISTGNQDFDSRVFGCKVKAANISRFKFLMVGGFVLFNVLQLSSLTYGNVRVSDWMPYLSNLSNTLMPAPINPYRVARNGLDDIYVASRANNIETRVTVLPPIKYVLQSQSRHCRDNFAGPLCDTLRGRTLGCVLAWLEDPVISKWVIAALFLSLVLNSYLMKAARWNLRQSEVIPDSSATVSQTKDSSNKLAEKRTVDAMLQEGRVSLLEDEEIVNLCLRGKISAHALEKTMERHPTMSRLEAFTRAVKIRRTVVSRTPSTIDVSSSLEYSKAPFENYDYTLVHGACCENIIGYLPLPVGAAGPLVIDGRNYFIPMATTEGVLVASASRGCKAINAGGGAVTVINADGMTRGPCLAFSSVSRAAEAKQWIDSDEGKKILATAFNSTSRFARLQGLKSAQAGTYLYVRFKSTTGDAMGMNMISKGVEKALEVMKGHGFSDMSTISVTGNYCVDKKPAAINWIDGRGKSVVAEALIPADAVRSVLKTDVDALVELNTAKNLVGSAMAGSIGGFNVHASNLVAAVLLATGQDPAQNVESSSCITIMKNVNNNLHISVSMPCIEVGTIGGGTILEPQAAMLDLLGVRGAHATNPGDNARQLARIVAAAVLAGELSTCAALAAGHLVSAHMAHNRSKVAAKTG
What is the function of this protein?
HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity).  Hmg1 and hmg2 catalyze the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate (By similarity).  The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase erg10B that catalyzes the formation of acetoacetyl-CoA.  The hydroxymethylglutaryl-CoA synthases erg13A and erg13B then condense acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.  The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases hmg1 and hmg2.  Mevalonate is also a precursor for the extracellular siderophore triacetylfusarinine C (TAFC) (PubMed:16110826, PubMed:22106303) (Probable).
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2, HMG-CoA reductase 2, Ergosterol biosynthesis protein hmg2.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PAT03_SOLTU
Sequence: MATTKSVLVLIFMILATTSSTFATLGEMVTVLSIDGGGIKGIIPGIILEFLEGQLQKMDNNADARLADYFDVIGGTSTGGLLTAMITTPNENNRPFAAAKDIVPFYFQHGPHIFNSSTGQFFGPKYDGKYLMQVLQEKLGETRVHQALTEVAISSFDIKTNKPVIFTKSNLARSPELDAKMSDICYSTAAAPTYFPPHYFATNTSNGDKYEFNLVDGAVATVADPALLSVSVATRRAEEDPAFASIRSLNYKQLLLLSLGTGTNSEFDKTHTAQETAKWGALQWMLVIQQMTEAASSYMTDYYLSTVFQDLHSQNNYLRVQENALTGTTTKADDASEANMELLVQVGENLLKKPVSKDNPETYEEALKRFAKLLSDRKKFRANKASY
What is the function of this protein?
Probable lipolytic acyl hydrolase (LAH), an activity which is thought to be involved in the response of tubers to pathogens.
What are the official names of this protein?
Patatin-03.
What is the protein family that this protein belongs to?
Belongs to the patatin family.
What are the subcellular locations of this protein?
Vacuole.
Protein: RL33B_SCHPO
Sequence: MPAQGHRLYVKAKHLSFQRSKHVIHPGTSIVKIEGCDSKEEAQFYLGKRVCYVYKSSKAVRGSKIRVIWGTIARPHGNSGAVRARFVHNLPAKTFGSSLRVMLYPSNI
What are the official names of this protein?
60S ribosomal protein L33-B, L37B.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eL33 family.
Protein: HIR1_GIBZE
Sequence: MHIIKPSWLSHCGEQKDFEVYSCHVSPDGKRLATAGGDGHVRVWSTESIYNANTPDYNKPRQLCHMSHHLGTIHSVRFSPNGRYLASGADDKIICVYHLDKNPPAATFGTNEPPPIENWKTYKRLIGHDNDVQDLAWSYDSSILVSVGLDSKVVVWSGHTFEKLKTLPAHQSHVKGITFDPANKFFATASDDRTIKIFRFTSPAPNATQHDMVNNFVLETTISSPFKSSPLTTYFRRCSWSPDGNHIAAANAVNGPVSSVAIIERTRWDSEINLIGHEAPTEVCMFSPRLFHTSKPDPSVDDKSPSLVTVIASAGQDKTLSIWNTNTSRPVVILQDLAGKSVSDLAWTPDGQTLFASSLDGSIVVAKFSEGELGWVAQPEENDKALQKYGASRKGMGIAEDVDGLMLENQSKAGESRAVESRMGALMGDLPDSTKESTPVTNGTKTTAPTSKPATNGQSEAEKDKEPEKEQEKEPEEAADKTAQRVKELKSRVTVGKDGKKRVAPLLVSSSGTGTSSLPQTQLVGTTSNNKAAQNDAPQTTLDLAKPFDGLPKGGIAAMLLGNKRRLNLGEAEEEEEPVSKRAATGPTTIVTNGHDSVEPAALVPVQHGVVPTPEFLRPAVMNPSIAFAQVRLAVPKIRSHVLRPLDRGILQGESSLEDASKTPENIILEAKNDPNPRDPSHVLVSKRGALIWEEWLPRAIILVTATKQFWAVACEDGSIHTWTPAGRRLLAPIILESQPVILEARGHWLLCITAVGLAHVWDLKTQSSPSPPVSLGPILDIATTSLNQHSATPGPGVTSAHLNSTGHIIVTLTNGDGYYYAREMFTWQRLSEAWWAVGSQYWNSNDSSISALQSTAVGPASKEGKDKESTKATVSSGIIPFLERHTTNEFLLKGRAYGLQRIIKMVVQRKEAENLESSVSIAHLETRIAGALQLGAREEFRLYLFTYAKRLGAEGARVKVEELLNSLLGGILEENEEEEDEDDGHGWFSKEGDLCGWDRKELLKDVVMILGKYRELQRLTLQYAKVLDISLEDGPVDVEQMDVEA
What is the function of this protein?
Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.
What are the official names of this protein?
Protein HIR1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat HIR1 family.
What are the subcellular locations of this protein?
Nucleus.
Protein: F16PC_LACCB
Sequence: MDLYSELTAKYQTVPAIATEIINLEAILNLPKPTEAFMSDIHGEYNAFQHVLRNGSGNVKSKIRSCFRDEMTEATLQRFAFLVYYPSERMAAIHREMAGDDLQQWYLTTFRRLIRLLAFTATKYTRSKVRKAMAPEFVYITEELLYNDADTPDKLAYYWQIIRNLIVLEQADQWIAATCQTIQRLTVDHFHVVGDIYDRGPAPDQVVESLIRRDRRHSVDIQWGNHDILWIGAAAGSALCIANLVRISARYNNLSILEDVYGINLRHLARLAEQYYQDNPAFSPKMERSDRPITEAERLQITQIHQAIAMIQFKLEGPVIKRRPEFDMDHRLVLEKLAPDFSTIKLNGDTYTIENGCFATVDPADPYKLLPEEQEVIDSLVESFTHSEKLHRHMDFLLDHGSMYLRYNRNLLLHGCVPVDEDGNFIGLTIKGTTYTGRQLFDMLEANLRLAYSQPTENADLATDLMWYLWTGPNSPLFGKHDMTTFERYFISDPKAHVEGRNPYYHLRKDPEFIKKILAEFVLDPEVGHVINGHTPVKKGTDPIMANNKMIVIDGGFSKPYQKTTGIGGYTLLDNSYGMQLVTHQPFTTKADAIANLTDIISTRRVVETEARRRTVAETDIGTELQDEVEVLKRRLGELREEE
What are the official names of this protein?
Fructose-1,6-bisphosphatase class 3, FBPase class 3, D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3.
What is the protein family that this protein belongs to?
Belongs to the FBPase class 3 family.
Protein: MTGA_RHIE6
Sequence: MPARRRWFENRPMLKRIVLAVLALVILPYVLIFFYLLPFIHPVSTLMLRDLVLLRGYDRRWVSLDQISPALVQSVMMSEDGQYCFHGGVDWAEMRMLVEDTLKGQATRGGSTIPMQTAKNLFLWNSRSFVRKAMELPLAVSTDFVLSKRRLMEIYLNIAEWGPGIYGVEAAAQHHFKVPASKLTRRQASLLAVSLPNPIDRNAGKPGRGLRRLAGVIERRAQGSGEYIKCIYE
What is the function of this protein?
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
What are the official names of this protein?
Biosynthetic peptidoglycan transglycosylase, Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 51 family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DDL_METPP
Sequence: MSATPDPRSFGKVAVLMGGTSAERDISLMSGGGVLKALQDAGVDAHAFDPKDHELVELRRQGFQRCFIALHGRHGEDGTVQGALELLRIPYTGSGVMASAIAMDKIMTKRVWLAEGLPTPRYVRLAPDEQTPERVRGVPDDLGLPLIVKPPREGSSIGVTKVLGYSQMQDAVALSARHDPDVLCEEFIDGAEVTCPVLGEGANARALPVIRIVPPEAGYDYQNKYFTDEVKYLCPSGLPADEEAEIQRIVLAAYRALGCRGWGRADLMIRASDRKPFLLEMNTSPGMTGHSLVPMSAKAAGLGYEQLCLHILQGAALDA
What is the function of this protein?
Cell wall formation.
What are the official names of this protein?
D-alanine--D-alanine ligase, D-Ala-D-Ala ligase, D-alanylalanine synthetase.
What is the protein family that this protein belongs to?
Belongs to the D-alanine--D-alanine ligase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYA_STRPF
Sequence: MKELSSAQIRQMWLDFWKSKGHCVEPSANLVPVNDPTLLWINSGVATLKKYFDGSVIPENPRITNAQKSIRTNDIENVGKTARHHTMFEMLGNFSIGDYFRDEAIEWGFELLTSPDWFDFPKDKLYMTYYPDDKDSYNRWIACGVEPSHLVPIEDNFWEIGAGPSGPDTEIFFDRGEDFDPENIGLRLLAEDIENDRYIEIWNIVLSQFNADPAVPRSEYKELPNKNIDTGAGLERLAAVMQGAKTNFETDLFMPIIREVEKLSGKTYNPDGDNMSFKVIADHIRALSFAIGDGALPGNEGRGYVLRRLLRRAVMHGRRLGINETFLYKLVLTVGQIMESYYPEVLEKRDFIEKIVKREEETFARTIDAGSGHLDSLLAQLKAEGKDTLEGKDIFKLYDTYGFPVELTEELAEDAGYKIDHEGFKSAMKEQQDRARAAVVKGGSMGMQNETLAGIVEESRFEYDTYSLESSLSVIIADNERTEAVSEGQALLVFAQTPFYAEMGGQVADTGRIKNDKGDTVAEVVDVQKAPNGQPLHTVNVLASLSVGTNYTLEINKERRLAVEKNHTATHLLHAALHNVIGEHATQAGSLNEEEFLRFDFTHFEAVSNEELRHIEQEVNEQIWNALTITTTETDVETAKEMGAMALFGEKYGKVVRVVQIGNYSVELCGGTHLNNSSEIGLFKIVKEEGIGSGTRRIIAVTGRQAFEAYRNQEDALKEIAATVKAPQLKDAAAKVQALSDSLRDLQKENAELKEKAAAAAAGDVFKDVQEAKGVRFIASQVDVADAGALRTFADNWKQKDYSDVLVLVAAIGEKVNVLVASKTKDVHAGNMIKELAPIVAGRGGGKPDMAMAGGSDASKIAELLAAVAETV
What is the function of this protein?
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala).  Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
What are the official names of this protein?
Alanine--tRNA ligase, Alanyl-tRNA synthetase, AlaRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HEM6_ECO27
Sequence: MKPDAHQVKQFLLNLQDTICQQLSAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV
What is the function of this protein?
Involved in the heme biosynthesis.  Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
What are the official names of this protein?
Oxygen-dependent coproporphyrinogen-III oxidase, CPO, Coprogen oxidase, Coproporphyrinogenase.
What is the protein family that this protein belongs to?
Belongs to the aerobic coproporphyrinogen-III oxidase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SEC_ARATH
Sequence: MISSKNGAAMISRPVFLSDRVDEVFSRKLDLSVSSSSSSSLLQQFNKTHEGDDDARLALAHQLYKGGDFKQALEHSNMVYQRNPLRTDNLLLIGAIYYQLQEYDMCIARNEEALRIQPQFAECYGNMANAWKEKGDTDRAIRYYLIAIELRPNFADAWSNLASAYMRKGRLSEATQCCQQALSLNPLLVDAHSNLGNLMKAQGLIHEAYSCYLEAVRIQPTFAIAWSNLAGLFMESGDLNRALQYYKEAVKLKPAFPDAYLNLGNVYKALGRPTEAIMCYQHALQMRPNSAMAFGNIASIYYEQGQLDLAIRHYKQALSRDPRFLEAYNNLGNALKDIGRVDEAVRCYNQCLALQPNHPQAMANLGNIYMEWNMMGPASSLFKATLAVTTGLSAPFNNLAIIYKQQGNYSDAISCYNEVLRIDPLAADALVNRGNTYKEIGRVTEAIQDYMHAINFRPTMAEAHANLASAYKDSGHVEAAITSYKQALLLRPDFPEATCNLLHTLQCVCCWEDRSKMFAEVESIIRRQINMSVLPSVQPFHAIAYPIDPILALEISRKYAAHCSIIASRFGLPPFTHPAGLPVKREGGFKRLRIGYVSSDFGNHPLSHLMGSVFGMHNRENVEVFCYALSANDNTEWRQRIQSEAEHFLDVSAMSSDAIAKIINQDKIQILINLNGYTKGARNEIFAMQPAPIQVSYMGFPGTTGATYIDYLVTDEFVSPLQYAHIYSEKLVHLPHCYFVNDYKQKNQDVLDPNSKPKRSDYGLPEDKFIFACFNQLYKMDPEIVNTWCNILKRVPNSALWLLRFPAAGEMRFRTYAAAQGVQPDQIIFTDVAMKSEHIRRSVLADVILDTPLCNGHTTGTDVLWAGVPMITLPLEKMATRVAGSLCLATGLGHGMIVNSLEEYEEKAVSLALNKPKLQALTKELRASRLTCPLFDTMRWVKNLERSYFKMWNLHCSGQQPQHFKVLENDLEFPHDR
What is the function of this protein?
O-linked N-acetylglucosamine transferase (OGT) that mediates O-glycosylation of capsid protein (CP) of virus in case of infection by Plum pox virus (PubMed:16014901).  OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine (PubMed:16014901).  Probably acts by adding O-linked sugars to yet unknown proteins.  Its OGT activity has been proved in vitro but not in vivo (PubMed:12136030).  Required with SPY for gamete and seed development (PubMed:16014901).  Mediates O-glycosylation of the DELLA protein RGA, a repressor of the gibberellin (GA) signaling pathway (PubMed:26773002).  O-glycosylation by SEC inhibits RGA binding to four of its interactors PIF3, PIF4, JAZ1, and BZR1 that are key regulators in light, jasmonate, and brassinosteroid signaling pathways, respectively (PubMed:26773002).  Activates ATX1 through O-GlcNAc modification to augment ATX1-mediated H3K4me3 histone epigenetic modification at FLC locus, thus preventing premature flowering (PubMed:30150325).
What are the official names of this protein?
Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC, Protein SECRET AGENT.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
Protein: VATA_METB6
Sequence: MEVKANQAKETKKGVLKRIAGPVVTAVNLDAHMYDVVRVGNEALMGEVIKIQGDNVIIQVYEDTTGIKPGEPVSNTGLSLAVELGPGLLTSIYDGIQRPLEVLVNKMGNFIERGVSAPGLSHEKKWTFKPVVKAGDKVEPGAILGEVQETNIVHKVMLPPNVKAGVVKTIKAGDFTVDEIIVILEDGREYPMIQRWPVRVPRPVKEKKNPTIPLLTGQRILDGLFPIAKGGTAAIPGPFGSGKTVTQQQLAKWSDAKIVVYIGCGERGNEMTEVLTEFPHLEDPTSGKPLMERTVLIANTSNMPVAAREASVYTGITIAEYFRDMGYDVSLMADSTSRWAEAMREISSRLEEMPGEEGYPAYLAARLSEFYERAGLVETLNHQSGSVSVIGAVSPPGGDFSEPVTQNTLRIVKVFWALDAKLSQRRHFPAINWLNSYSLYLDALHDWYDKNVSPDWNKLRSWAMGVLQKEAELQEIVQLVGSDALPETEQITIEVARMIREIFLQQNAYDAVDTFCDMQKQYDMMKAIRLYSDLANTAQAAGVSPAQITTIKAKNELPQIKFVKDYKQPLAKIEKDMDAEFNALRSAA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The archaeal alpha chain is a catalytic subunit.
What are the official names of this protein?
V-type ATP synthase alpha chain, V-ATPase subunit A.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
Protein: RUVB_EHRCR
Sequence: MKNILQSTECLEDQQNVSMRPNLLDDFIGQSSVVNNLKIFINAAYTRKEPMDHVLLYGPPGLGKTTLAHIIAKELKVNFRSTAGPLLSKAGDLAAILTNLQAKDILFIDEIHRLNRNIEEILYSAMEDFCLDIIVGEGCGARTLRVDLPPFTLVGATTRIGLLSNPLRDRFGIPIHLEFYSTEELTKVIQRAAKVIKTNISNSGAQEISLRSRGTPRIALRLLRRIRDFMEVTEHNKIITDTFADKALLRLGIDKLGLDRQDIQYLKFIYDSNNPTGIDTISSGLSEDTGNIEETIEPYLIKINFIQRTPRGRVITEKAISHLREQEYI
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time.  Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange.  Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration.  The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration.  Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvB.
What is the protein family that this protein belongs to?
Belongs to the RuvB family.
Protein: MEOX2_RAT
Sequence: MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQSNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPRDYGRQALSPAEVEKRSGSKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSLANDDSRDSDHSSEHAHL
What is the function of this protein?
Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation.  Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity).  May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (PubMed:8098844).  Also acts as a negative regulator of angiogenesis.  Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation.  While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (By similarity).  Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).
What are the official names of this protein?
Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2.
What are the subcellular locations of this protein?
Nucleus. Nucleus speckle.
Protein: GSTA1_BOVIN
Sequence: MAGKPTLHYFNGRGRMECIRWLLAAAGVEFEEKFIEKPEDLDKLKNDGSLMFQQVPMVEIDGMKLVQTRAILNYIATKYNLYGKDMKERALIDMYSEGVADLGEMIMHFPLCPPAEKDAKLTLIREKTTNRYLPAFENVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDPSLLANFPLLKALKARVSNIPAVKKFLQPGSQRKPPTDEKKIEEARKVFKF
What is the function of this protein?
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds.  Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2).  It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis.  Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.
What are the official names of this protein?
Glutathione S-transferase A1, 13-hydroperoxyoctadecadienoate peroxidase, Androst-5-ene-3,17-dione isomerase, GST class-alpha member 1, Glutathione S-transferase alpha-1.
What is the protein family that this protein belongs to?
Belongs to the GST superfamily. Alpha family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SYDND_BORRA
Sequence: MFKIIKCNQINNKLINKKIEINGWVKKIRNHGKVTFINIRDRYDEAQILVSDEKLLKITSQIKMEYCIKIQGKLNLRPLELVNREMKTGELEIIAENIDIISKCNELPFMIENNNNASDNSKLEYRYLDLRREEQKQKIILRSKVIHIIRNHLTKQDFLELETPTFVKSTPEGARDFLVPSRIHKGHFYALPQSPQIYKQLAMIAGLDKYFQIARCYRDEDSRGDRQPEFTQLDLEMSFIKKENIFKLIENLIFTIFKNSLNITLPKKFKKITYKDAMNIYGSDKPDTRYELLIQDMSKALKQSPFDVFKDTLQNKGTIKALIIKNQAHNFSRSKINSLEEHAKLYKARTLYFTKIENNEFTGGIAKFINPIKKTLIETYSLKNNDIIFFIADLWETACKAIGQIRIKIATELNLINKNIFEFLWIYDFPLFEYDEDTQSYKAAHHMFSMPQAKYINTLESNPSKVLGEVYDIVLNGTELGSGSIRVHTKELQQRIFNIVGFNDKIAEERFDFFLKALEYGAPIHGGIAIGIDRLLMLMTNSNSIKDVILFPKNSFAASPLDKSPSKISDEQLKELNLTIENK
What is the function of this protein?
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn).  Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
What are the official names of this protein?
Aspartate--tRNA(Asp/Asn) ligase, Aspartyl-tRNA synthetase, AspRS, Non-discriminating aspartyl-tRNA synthetase, ND-AspRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPT_STRZJ
Sequence: MKLLEERILKDGHILGDNILKVDSFLTHQVDFSLMREIGKVFAEKFAATGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVQAIGIVIEKSFQDGRDLLEKAGYPVLSLARLDRFENGQVVFKEADL
What is the function of this protein?
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
What are the official names of this protein?
Xanthine phosphoribosyltransferase, XPRTase.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XDHB_ECO57
Sequence: MFDFASYHRAATLADAINLLADNPQAKLLAGGTDVLIQLHHHNDRYRHIVDIHNLAELRGITLAEDGSLRIGSATTFTQLIEDSITQRHLPALCAAASSIAGPQIRNVATYGGNICNGATSADSATPTLIYDAKLEIHSPRGVRFVPINGFHTGPGKVSLEHDEILVAFHFPPQPKEHVGSAHFKYAMRDAMDISTIGCAAHCRLDNGNFSELRLAFGVAAPTPIRCQHAEQTAQNAPLNLQTLEAISESVLQDVAPRSSWRASKEFRLHLIQTMTKKVISEAVAAAGGKLQ
What is the function of this protein?
Presumed to be a dehydrogenase, but possibly an oxidase.  Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) (By similarity).
What are the official names of this protein?
Xanthine dehydrogenase FAD-binding subunit.