PharMolix/UniProtQA huggingface dataset:
Protein: LEU1_PARL1
Sequence: MLKNPSVKYRAFAPVPLSDRQWPSKTITKPPIWMSTDLRDGNQALFEPMNAERKLRMFEMLVKIGFKEIEAGFPSASDTDFGFIRKLVEEGRVPDDVHIEVLTQARPELIARTMESLKGAKNAIVHVYNATAPNFREVVFQQGKQGVKAIATESARQIKEIAATQPETNWTFQYSPEVFSGTELDFAKEVVDAVTEIWEAGPERKVVINLPATVEMATPNIYADQIEWMHRNLERRDGIILSVHPHNDRGTAVAAAELAIMAGADRVEGCLFGNGERTGNVDLVTLALNLYSQGIDPGLDFAQINEIARTAEYCTQLPIHPRHPYVGDLVFTAFSGSHQDAIKKGLAAYKAGDIWQVPYLPLDPKDLGRTYESIIRVNSQSGKGGVSYLLEAEYDLRLPRRLQVEFSSAVQRVTDDTGKEVRAADIWRIFEEEYLTRAEPIEYLSHSLYDESGKQGVKIRIRRFGKEEELSGSGNGPIDAAMDALKLGVELRHYEEHSIGSGTDAKAVAFMEVADPEHPGDLFGVGIDANIITASFKAMLSAANRAAARRPKSEWARLCGGAE
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
Protein: THIG_CORJK
Sequence: MLEIAGKKFDSHLIMGTGGATSQTLLEKALVASGTQLTTVAMRRFRAGNTPSTAGASNGAAGGESVFGLLNRLGIDVLPNTAGCRTAKDAILTAQLAREALGTNWVKLELIADDRTLLPDVVELVDTCEMLVANGFEVLAYTSDDPVVAKRLEDAGAAAVMPLGSPIGTGLGILNPHNIELICARASVPVLLDAGVGTTSDAALAMELGCSGVLLASAVNRCQDPVAMATAMRHAVEAGRLAAAAGRIPKRTHAQGALASSSFEGLASWDEDWAEEVL
What is the function of this protein?
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine.  Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS.  In vitro, sulfur can be provided by H(2)S.
What are the official names of this protein?
Thiazole synthase.
What is the protein family that this protein belongs to?
Belongs to the ThiG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: COX2_LEOSA
Sequence: MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISTLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTSDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFENWSASMI
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 2, Cytochrome c oxidase polypeptide II.
What is the protein family that this protein belongs to?
Belongs to the cytochrome c oxidase subunit 2 family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: Y3818_MYCTO
Sequence: MQVTSVGHAGFLIQTQAGSILCDPWVNPAYFASWFPFPDNSGLDWGALGECDYLYVSHLHKDHFDAENLRAHVNKDAVVLLPDFPVPDLRNELQKLGFHRFFETTDSVKHRLRGPNGDLDVMIIALRAPADGPIGDSALVVADGETTAFNMNDARPVDLDVLASEFGHIDVHMLQYSGAIWYPMVYDMPARAKDAFGAQKRQRQMDRARQYIAQVGATWVVPSAGPPCFLAPELRHLNDDGSDPANIFPDQMVFLDQMRAHGQDGGLLMIPGSTADFTGTTLNSLRHPLPAEQVEAIFTTDKAAYIADYADRMAPVLAAQKAGWAAAAGEPLLQPLRTLFEPIMLQSNEICDGIGYPVELAIGPETIVLDFPKRAVREPIPDERFRYGFAIAPELVRTVLRDNEPDWVNTIFLSTRFRAWRVGGYNEYLYTFFKCLTDERIAYADGWFAEAHDDSSSITLNGWEIQRRCPHLKADLSKFGVVEGNTLTCNLHGWQWRLDDGRCLTARGHQLRSSRP
What are the official names of this protein?
Putative Rieske 2Fe-2S iron-sulfur protein MT3926.
Protein: CL061_HUMAN
Sequence: MGGKSAVRHQLVLDCPREAASSAPALRPLGAAATSRAAPLAPLPAPSPRWGLGCGRVRYPGPHPRRAVEPAAGPLSAPIIAGGHPAEAAAGSAKQQPRHSREVPRPPVPQHPSGNSRSALQEAKTEQTKTP
What are the official names of this protein?
Putative uncharacterized protein encoded by LINC01465.
Protein: RS5_CAMJE
Sequence: MEKYNREEFEEVIVDIGRVTKVVKGGRRFRFTALVIVGNRKGLVGVGYGKAKEVPDAIRKAVDDAFKNIVEVKTKGSTIAHDVEVKYNASRILLKPASEGTGVIAGGSTRPIVELAGIKDILTKSLGSNNSANVVRATIKALTMLKG
What is the function of this protein?
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
What are the official names of this protein?
30S ribosomal protein S5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS5 family.
Protein: MFGM_CAPHI
Sequence: DFGHIQYVAAYR
What is the function of this protein?
Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors.  Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner.  Zona pellucida-binding protein which may play a role in gamete interaction.  Contributes to phagocytic removal of apoptotic cells in many tissues.  Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing.  Promotes VEGF-dependent neovascularization (By similarity).
What are the official names of this protein?
Lactadherin, MFGM, Milk fat globule-EGF factor 8, MFG-E8, SED1.
What are the subcellular locations of this protein?
Membrane; Peripheral membrane protein. Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Peripheral membrane protein. Note=Located in the acrosomal region of zona-pellucida bound sperm.
Protein: MPRA_MYCTA
Sequence: MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRGTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP
What is the function of this protein?
Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host.  Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).
What are the official names of this protein?
Response regulator MprA, Mycobacterial persistence regulator A.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MTLD_OCEIH
Sequence: MKTAVHFGAGNIGRGFIGLLLYQSGYQTIFIDVNNQVIDEINKQKSYHVYLAGKEKQELTVNHITGINSIKEPDAVTEAIVKADVVTTAVGPTILPVIAKAISKGLQERTKQNNSPLNIIACENMVGGSSLLKEHVFESLEAHKIGEFDRLYGFPDAAVDRIVPNQTNKNLLDVMVEPYYEWVVEKKKIVGEVPPIFGITYVDDLAPYIERKLFTVNTGHAIPAYLGTHLGYDTIVEAMKDLRIDDTIYGALAESGEALIHAYGFNREMHQEYVSKIIQRFQNPYISDDVKRVARGPIRKLGAKDRLVKPALMYIEYTGKIPVYLAKTIAAALLFNNDEDREAIELQKKISATGYQQAFVEVSGCDSDSILTKKVIEQLRLLQNKK
What are the official names of this protein?
Mannitol-1-phosphate 5-dehydrogenase.
What is the protein family that this protein belongs to?
Belongs to the mannitol dehydrogenase family.
Protein: Y3148_BURP0
Sequence: MSKSSDRINLTNQFLIAMPNMADPTFSGTVVYLCDHSERGALGLVINRPTDIDLESLFNRIDLKLEIEPLLHIPVYFGGPVQTERGFVLHEPVEGSAYNSSMTVEGGLEMTTSKDVLEAVATGTGPKRFLLTLGHAGWGAGQLEEEISKNGWLTVAADPRIVFDTPAEERFEAALGLLGVSSSMLSGEAGHA
What are the official names of this protein?
UPF0301 protein BURPS1106A_3148.
What is the protein family that this protein belongs to?
Belongs to the UPF0301 (AlgH) family.
Protein: TRI39_HUMAN
Sequence: MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
What is the function of this protein?
Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251).  Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).  Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner (PubMed:26363554).
What are the official names of this protein?
E3 ubiquitin-protein ligase TRIM39, RING finger protein 23, RING-type E3 ubiquitin transferase TRIM39, Testis-abundant finger protein, Tripartite motif-containing protein 39.
What is the protein family that this protein belongs to?
Belongs to the TRIM/RBCC family.
What are the subcellular locations of this protein?
[Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Colocalizes with CDKN1A in the nucleus.
Protein: ISPF_THENN
Sequence: MESDSMFIGFGYDRHPLVEGRRLVLAGVEIDAPLGSLGHSDGDVLSHAIIDALLGAGCLGDIGTWFPETKEYKDANSLDLLKETVKILEERGFSVVNVDATVVASIVKLSPYREKILENLKSALETSRVNVKFKSGNTLGFEGEERGISAYAVCLVEEKKCTKSI
What is the function of this protein?
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds.  Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
What are the official names of this protein?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MECDP-synthase, MECPP-synthase, MECPS.
What is the protein family that this protein belongs to?
Belongs to the IspF family.
Protein: VIP1_YEAST
Sequence: MSGIKKEPIESDEVPQQETKNNLPSAPSEMSPLFLNKNTQKAMQSIAPILEGFSPKTSASENMSLKLPPPGIQDDHSEENLTVHDTLQRTISTALGNGNNTNTVTTSGLKKADSESKSEADPEGLSNSNIVNDADNINSISKTGSPHLPQGTMDAEQTNMGTNSVPTSSASSRKSSTSHPKPRLPKVGKIGVCAMDAKVLSKPMRHILNRLIEHGEFETVIFGDKVILDERIENWPTCDFLISFFSSGFPLDKAIKYVKLRKPFIINDLIMQKILWDRRLCLQVLEAYNVPTPPRLEISRDGGPRANEELRAKLREHGVEVKPVEEPEWKMVDDDTLEVDGKTMTKPFVEKPVDGEDHNIYIYYHSKNGGGGRRLFRKVGNKSSEFDPTLVHPRTEGSYIYEQFMDTDNFEDVKAYTIGENFCHAETRKSPVVDGIVRRNTHGKEVRYITELSDEEKTIAGKVSKAFSQMICGFDLLRVSGKSYVIDVNGFSFVKDNKAYYDSCANILRSTFIEAKKKMDMEKKNLPIIREEKEQKWVFKGLAIIIRHADRTPKQKFKHSFTSPIFISLLKGHKEEVVIRNVNDLKIVLQALRIALDEKAGNPAKIKVLANALEKKLNFPGTKIQLKPVLNKENEVEKVQFILKWGGEPTHSAKYQATELGEQMRQDFDLLNKSILQNIKIFSSSERRVLHTAQYWTRALFGADELGSDEISIRKDLLDDSNAAKDLMDKVKKKLKPLLREGKEAPPQFAWPSKMPEPYLVIKRVVELMNYHKKIMDNNFAKKDVNSMQTRWCTSEDPSLFKERWDKLFKEFNNAEKVDPSKISELYDTMKYDALHNRQFLENIFDPGLPNEAIADELGSHSLVDRYPINVLAKNNFKIIDSHSMNNSGKNSSNSVGSLGWVLESGKTSTARNPKSSSQFDEPRFMQLRELYKLAKVLFDFICPKEYGISDAEKLDIGLLTSLPLAKQILNDIGDMKNRETPACVAYFTKESHIYTLLNIIYESGIPMRIARNALPELDYLSQITFELYESTDASGQKSHSIRLKMSPGCHTQDPLDVQLDDRHYISCIPKISLTKHLDMDYVQQKLRNKFTRVIMPPKFTPVNITSPNLSFQKRKTRRKSVSVEKLKRPASSGSSSSTSVNKTLD
What is the function of this protein?
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17412958).  Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4.  Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity).  Required for maintaining cellular integrity, normal growth and interactions with the ARP complex (PubMed:10388810).  Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability (PubMed:17412959).  Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth (PubMed:10388810).  Regulates polarized growth and modulates interphase microtubule cytoskeleton.  Regulates microtubule dynamics without the requirement of microtubule plus-end tracking protein Mal3.  Required for growth zone selection (By similarity).
What are the official names of this protein?
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase, InsP6 and PP-IP5 kinase.
What is the protein family that this protein belongs to?
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton.
Protein: DER_VIBVU
Sequence: MIPVVALVGRPNVGKSTLFNRLTRSRDALVADFPGLTRDRKYGQAKVGEHDFIVIDTGGIDGSEEGVETKMAEQSLAAIREADVVLFMVDGRAGLTPSDEAIAAHLRKIEKATMLVVNKVDGIDADAASADFWQLGVDEMYQIAAAHGRGVTALIERALDPFFDNLLSANNEGEIEDLTDMEDEDAEQQEYSEEDAEESLKRLQDQPIKLAIIGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMERDGREYVLIDTAGVRRRGKVHETVEKFSVVKTLKAVEDANVVLLVIDARENISDQDLSLLGFALNAGRSIVLAVNKWDGLDNEVKENVKKELDRRLGFVDFARIHFISALHGTGVGHLFESVQEAYRSATTRVGTSVLTRIMKMATEDHQPPMVRGRRVKLKYAHAGGYNPPIVVIHGNQVRELPDSYKRYLMNYFRKSLDIMGTPIRIQFQNSDNPFENRVNKMTLSQERARKRMMSAVKNRKK
What is the function of this protein?
GTPase that plays an essential role in the late steps of ribosome biogenesis.
What are the official names of this protein?
GTPase Der, GTP-binding protein EngA.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
Protein: YGK5_SCHPO
Sequence: MFSWANIGSNEYLPLKNDRKAYLNQWAKRSGLAIAAICILGILILAIVKLFCFKAIIFPIVGGSFNNGTNVFQSTVIVISLDGFRADYLYRGFTPNLLSLAERNVHVPFLIPSFPSITFPNHYTIVTGLYPESHGIVSNNFFDPVTGKQFVNSMPECNKDPTWWDKGEPIWVNAERNNVRSAVHMWPGNEVENHGYRPTYSDGFNFDTTLREKKDRILEWLDLPDKDRPQLLLAYAPHVDMVGHAFGPDSPELNIIIQEVDIVIGELIEGLKKRNIDKHVNIIFLSDHGMAPTSDNRLIWLDNMFNLSAVAHRDAWPLGGFRGESDLDDEYIYESLVNYSRSSLPSAENWNVYSKKDIPSRWHYSNNERIAPVWMIPDVGWSLVSMLDHSPELEYEPLGVHGYDNLSPVMRALFIASGSSFKNFKGKKLAPFQNTEIYGILSHILDLPAQPNNGTYEGALPLRRNRNSTKEWLLKDIEQAYSKLI
What are the official names of this protein?
Uncharacterized pyrophosphatase/phosphodiesterase C725.05c.
What is the protein family that this protein belongs to?
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: APT_CLAM3
Sequence: MPETPASDLVRSLLLTVPDFPQPGILFRDLTPVLADGPALRAVVDDLVAACGPVDAVAGVEARGFLLAAAAAYASGVGTLAVRKAGKLPGEVLRETYALEYGEAAIELHPGQLAPGSRVLLLDDVLATGGTLEAAARLLERAGYEVAGIGVVLELADLGGRERLAGHDVRAILTL
What is the function of this protein?
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
What are the official names of this protein?
Adenine phosphoribosyltransferase, APRT.
What is the protein family that this protein belongs to?
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RK20_CYCTA
Sequence: MTRIKRGYIARKRRKKILAFASGFRGAHSKLFRTADQQKIRALVSAHRDRSKRKRDLRRLWITRINAAARNNGVSYNKFIRYLYKRQLLSNRRILAQIAVLDKNCFSTIINNIIE
What is the function of this protein?
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit.  It is not involved in the protein synthesizing functions of that subunit.
What are the official names of this protein?
50S ribosomal protein L20, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL20 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: EIF3G_BOVIN
Sequence: MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSLEPELLPGAPLPPPKEVINGNIKTVTEYRIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN
What is the function of this protein?
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.  The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).  The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.  The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.  The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.  This subunit can bind 18S rRNA.
What are the official names of this protein?
Eukaryotic translation initiation factor 3 subunit G, eIF3g, Eukaryotic translation initiation factor 3 RNA-binding subunit, eIF-3 RNA-binding subunit, Eukaryotic translation initiation factor 3 subunit 4, eIF-3-delta, eIF3 p42, eIF3 p44.
What is the protein family that this protein belongs to?
Belongs to the eIF-3 subunit G family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region.
Protein: DGCM_ECOLI
Sequence: MITHNFNTLDLLTSPVWIVSPFEEQLIYANSAAKLLMQDLTFSQLRTGPYSVSSQKELPKYLSDLQNQHDIIEILTVQRKEEETALSCRLVLRKLTETEPVIIFEGIEAPATLGLKASRSANYQRKKQGFYARFFLTNSAPMLLIDPSRDGQIVDANLAALNFYGYNHETMCQKHTWEINMLGRRVMPIMHEISHLPGGHKPLNFVHKLADGSTRHVQTYAGPIEIYGDKLMLCIVHDITEQKRLEEQLEHAAHHDAMTGLLNRRQFYHITEPGQMQHLAIAQDYSLLLIDTDRFKHINDLYGHSKGDEVLCALARTLESCARKGDLVFRWGGEEFVLLLPRTPLDTALSLAETIRVSVAKVSISGLPRFTVSIGVAHHEGNESIDELFKRVDDALYRAKNDGRNRVLAA
What is the function of this protein?
Part of a signaling cascade that regulates curli biosynthesis.  The cascade is composed of two cyclic-di-GMP (c-di-GMP) control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD (PubMed:23708798).  DgcM stimulates activity of MlrA by direct interaction, leading to the transcription of csgD.  It also catalyzes the synthesis of c-di-GMP via the condensation of 2 GTP molecules, which contributes to the c-di-GMP pool generated by module I in a positive feedback loop.  Production of c-di-GMP contributes to but is not essential for MlrA activation (PubMed:17010156, PubMed:23708798).
What are the official names of this protein?
Diguanylate cyclase DgcM, DGC.
Protein: RLMC_SHEON
Sequence: MSTLVQCGYFERGQCQSCRHIKLPMVQQLAAKTQELQQLLAPFVVSTNTQFLPPVVGEDSGFRNKAKMVVLGAAHAPVLGIVSPNGEAVSLCDCLLYPADMQALLYRLERFVQQAGIPPYRIDKAKGELKYILLTRSQVRGEYMLRFVLRSPDAIARIERELPALMAEYPQINVVSVNIQPIHMAILEGDEEIFLTENTRLEERFNDVPLFIRPKSFFQTNPHVAAKLYQTAREWVGEFAPKSLWDLFCGVGGFGLHCASKDIPLTGIEIEAEAIACAKMSAQMMGLDNVQFMALDSTDFAKGDAAATKPDLIIVNPPRRGIGESLCDALSEFAPRAILYSSCNPKTLAKDLVHIRGYQLTRVQLFDLFPHSDHFEVLAMLVKDSR
What is the function of this protein?
Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
What are the official names of this protein?
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC, 23S rRNA(m5U747)-methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
Protein: FLGH_HELPJ
Sequence: MKKALYLGAVAFGVVFSMASANEPNIDFNPPNYVEETPSKEFIPELNKLGSLFGQGERPLFADRRAMKPNDLITIVVSEKASANYSSSKDYKSASGGNSTPPRLTYNGLDERKKKEAEYLDDKNNYNFTKSSNNTNFKGGGSQKKSEDLEIVLSARIIKVLENGNYFIYGNKEVLVDGEKQILKVSGVIRPYDIERNNTIQSKFLADAKIEYTNLGHLSDSNKKKFAADAMETQMPY
What is the function of this protein?
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
What are the official names of this protein?
Flagellar L-ring protein, Basal body L-ring protein.
What is the protein family that this protein belongs to?
Belongs to the FlgH family.
What are the subcellular locations of this protein?
Cell outer membrane. Bacterial flagellum basal body.
Protein: EFTS_SHIFL
Sequence: MAEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAKKAGNVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAVAGKITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGARIGVLVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDIAMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNAEVTGFIRFEVGEGIEKVETDFAAEVAAMSKQS
What is the function of this protein?
Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP.  It remains bound to the aminoacyl-tRNA. EF-Tu. GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
What are the official names of this protein?
Elongation factor Ts, EF-Ts.
What is the protein family that this protein belongs to?
Belongs to the EF-Ts family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL34_BURMS
Sequence: MKRTYQPSVTRRKRTHGFRVRMKTAGGRKVINARRAKGRKRLAI
What are the official names of this protein?
50S ribosomal protein L34.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL34 family.
Protein: V1R50_MOUSE
Sequence: MSKANLLHTDNNMKITLFSEVSVGISANSILFVVHLCKLLHENKPKPIDLYIAFFSITQLMLLITMGLIAVDMFMPWGRWDSTTCQSLIYLHRLLRGLTFCATCLLNVLWTITLSPRSSCLTKFKHKSPHHISGAFLFFCVLYMSFSSHLLVSIIATFNSTSDNFLYVTQSCSILPVSYSRTSILSTMMTMREAFLIGLMALSSGYVVVLLWRHKKQARHLHSTSLSSKASPEQRATSTIMLLMGFFVVLYILDTVIFQARLKFKDVSTFFCVKIIISHSYATFSPFVFICNDKYMIKFVTSMCGRIVNV
What is the function of this protein?
Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
What are the official names of this protein?
Vomeronasal type-1 receptor 50, Pheromone receptor VN2, Vomeronasal receptor 2, Vomeronasal type-1 receptor A5, Vomeronasal type-1 receptor B1.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: YCHH_ECOLI
Sequence: MKRKNASLLGNVLMGLGLVVMVVGVGYSILNQLPQFNMPQYFAHGAVLSIFVGAILWLAGARVGGHEQVCDRYWWVRHYDKRCRRSDNRRHS
What are the official names of this protein?
Uncharacterized protein YchH.
Protein: 137R_IIV6
Sequence: MNEIIITIIVLILLLFITLSRNDRNNNQSNNGKKEKLIKCKKEVQQLRQKLDQLTFQ
What are the official names of this protein?
Uncharacterized protein 137R.