PharMolix/UniProtQA huggingface dataset:
Protein: RS18_ECOLI
Sequence: MARYFRRRKFCRFTAEGVQEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
What is the function of this protein?
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S18, Small ribosomal subunit protein bS18.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS18 family.
Protein: SYI_LISMF
Sequence: MEYKDTLLMPKTDFPMRGNLPNKEPEWQAKWEEEKLYEKIQEKNAGRKAYILHDGPPYANGELHMGHALNKTIKDIIVRYKSMAGFSSPYVPGWDTHGLPIETAIAKKGVKRKEMSIAEFRKLCAEYAMTQVDGQRTGFKRLGINGDWENPYITLLPEYEAEQIKVFGEMAKKGYIYKGKKPVYWSPSSESALAEAEIEYQDKKSASIFVAFKVTDGKGVLDEGTNIVIWTTTPWTIPANMGITVNPDLDYVVIESAGEKYVVAEALLPSLREKLGFEDATVVKTVRGSELDRVVTKHPFYDRDSLVMNGEHATAEAGTGAVHTAPGHGEDDFLIGKKYDLEVLAPLDDRGVFTEEAPGFEGVFYDTANKMVTEKLEEVGALLKMEFITHSYPHDWRTKKPVIFRATAQWFASIDAFRDDLLAAVKGVNWTPAWGETRLFNMVRDRGDWVISRQRAWGVPLPIFYAENGEAIITDETINHISELFREHGSNVWFERDVKDLLPAGFTHPGSPNGEFTKETDIMDVWFDSGSSHQAVLNARPELSRPADLYMEGSDQYRGWFNSSLTTAVAITGEAPYRNVLSHGFALDGEGRKMSKSLGNTLLPGKVIKQLGADIVRLWVASVDYQADVRVSDEILKQVSEVYRKIRNTMRFLLGNINDFNPTTNAVSYENLREVDKYMLIKLNDLVKNVKDNYEAFEFSTIYHQINNFCTVELSQFYMDFAKDVVYIEAADSHDRRAMQTVFYEAVVTLTKLLAPILPHTTEEVWNSLIGEGVESIHLQDLPEVKVLADSEEITAKWDAFMQIRDNVQKALEFARNEKLIGKSMLAKVTLYVDGEAKTLFDSLEGDFAQLFIVSDFELVEGLENAPESAFKSNQVAVQITVAEGETCERCRVVKKDVGVNPKHPTLCGRCADIVVKHYEA
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YL057_MIMIV
Sequence: MNNYFTTVYPIKKILEKNGCKNCKVGYTGQRAFIIKCEKCKNYDRGNKLKKKNGRVEVSTSQELSIFPIGSMVSYINNKDEFRKGGYITKITADYFIYVTPDFETKYRVRYKNIKKMWVGDVYKVSSDIVSLSETTQPKTDFPVKIGNITVYYASDNTKKKNFMKTKKYKTSLEWYNYFHKN
What are the official names of this protein?
Uncharacterized protein L57.
What is the protein family that this protein belongs to?
Belongs to the mimivirus L6/L7/L57 family.
Protein: RL18_GEODF
Sequence: MSSLSQKKNSRLKRQVRVRKKIKGTAERPRLNVFKSAKHIYAQLINDADGSTVASASTLLDEVSTGLDYTGNKEAAQKVGAALAKKALAKEISKVVFDRNGFLYHGRIKALAEAARENGLSF
What is the function of this protein?
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
What are the official names of this protein?
50S ribosomal protein L18.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL18 family.
Protein: KPRS_NEIMA
Sequence: MAAYDSLMVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLENVRGRDVFILQPTCAPTNDNLMEILTMADALKRASAGRITTAIPYFGYARQDRRPRSVRVPISAKLVANMLYSAGIDRVLTVDLHADQIQGFFDIPVDNIYATPILLNDIKQQRIENLTVVSPDIGGVVRARAVAKSLNADLAIIDKRRPKANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKERGAERVLAYASHAVFSGEAVSRIASSEIDQVVVTDTIPLSEAAKNCDRIRQVTIAGLLAETVRRISNEESVSYLFNEEVMTGSMLLP
What is the function of this protein?
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
What are the official names of this protein?
Ribose-phosphate pyrophosphokinase, RPPK, 5-phospho-D-ribosyl alpha-1-diphosphate synthase, Phosphoribosyl diphosphate synthase, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase, PRPPase.
What is the protein family that this protein belongs to?
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SNP47_RAT
Sequence: MSSDVRVHTWPCSYYLDLEKQWLPGKLTLTPRSLKFSVDKAEEVLVGLPLSSITEIRKETSLFIFSAITVLEKGQAKHWFSSLRPSRNVVFNIIEHFWRELLLSQPGTAANPTSPMTRGQELMGLMASSQRRMEDTAKVLHHQGEQLDSVMRGLEKMESDLDVADRLLTELETPSWWPFSAKFWKTPVEAKPRDSVSVAPCEPFGKEGVVIRVPAVVSQRTESHSKPGKLTVLVSGLEIHDSSSLLLHRFEKEDVDDIKVHSPYEVSIRQRFIGKPDVAYRLISAKMPEVIPILEVQFSKKIELLEDALVLRSRGRASPAEGGCSIRHAASRLMGCTTHQELPTGGQEGQQSQLQKDWPLLSEGEAQELTQILSKLKGLALDTEAELERQDAALDGITVAVDRATLTVDKHNRRMRKLL
What is the function of this protein?
May play a role in intracellular membrane fusion.
What are the official names of this protein?
Synaptosomal-associated protein 47, SNAP-47, Synaptosomal-associated 47 kDa protein.
What is the protein family that this protein belongs to?
Belongs to the SVAP1 family.
What are the subcellular locations of this protein?
Endomembrane system. Cytoplasm, perinuclear region. Note=Appears to be exclusively membrane-bound.
Protein: BIOB_CERS4
Sequence: MIRPALRTDWTLEEARAIHALPFPELMHRAQTLHRAHFDPTAIETASLLSIKTGGCPEDCGYCSQSAHHDTGVKATKLMGTEEVLAAARRAKAAGAQRFCMGAAWRSPKDRDMDRLCDMVRGVADLGLETCMTLGMLSPGQVARLKAAGLDFYNHNIDTSPAYYARIASTRTMEDRLETVEQVRRGGIKVCCGGILGMGEAEEDRIALLVTLATLPAHPDSVPVNLWNEIEGVPVQGRAQAVDPFALVRIVALARILMPASVVRLSAGRTEMSDELQALCFLAGANSIFVGDQLLTTGNPAAWKDRDLLSRLGLHVAPARARPPVAAD
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: KIF2B_HUMAN
Sequence: MASQFCLPESPCLSPLKPLKPHFGDIQEGIYVAIQRSDKRIHLAVVTEINRENYWVTVEWVEKAVKKGKKIDLETILLLNPALDSAEHPMPPPPLSPLALAPSSAIRDQRTATKWVAMIPQKNQTASGDSLDVRVPSKPCLMKQKKSPCLWEIQKLQEQREKRRRLQQEIRARRALDVNTRNPNYEIMHMIEEYRRHLDSSKISVLEPPQEHRICVCVRKRPLNQRETTLKDLDIITVPSDNVVMVHESKQKVDLTRYLQNQTFCFDHAFDDKASNELVYQFTAQPLVESIFRKGMATCFAYGQTGSGKTYTMGGDFSGTAQDCSKGIYALVAQDVFLLLRNSTYEKLDLKVYGTFFEIYGGKVYDLLNWKKKLQVLEDGNQQIQVVGLQEKEVCCVEEVLNLVEIGNSCRTSRQTPVNAHSSRSHAVFQIILKSGRIMHGKFSLVDLAGNERGADTTKASRKRQLEGAEINKSLLALKECILALGQNKPHTPFRASKLTLVLRDSFIGQNSSTCMIATISPGMTSCENTLNTLRYANRVKKLNVDVRPYHRGHYPIGHEAPRMLKSHIGNSEMSLQRDEFIKIPYVQSEEQKEIEEVETLPTLLGKDTTISGKGSSQWLENIQERAGGVHHDIDFCIARSLSILEQKIDALTEIQKKLKLLLADLHVKSKVE
What is the function of this protein?
Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement.  Has microtubule depolymerization activity (PubMed:17538014).  Plays a role in chromosome congression (PubMed:23891108).
What are the official names of this protein?
Kinesin-like protein KIF2B.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Association with kinetochore is transient.
Protein: SYG_SCHPO
Sequence: MTEVSKAAAFDRTQFEELMKKRFFFSPSFQIYGGISGLYDYGPPGSALQSNLVDIWRKHFVIEESMLEVDCSMLTPHEVLKTSGHVDKFADWMCKDPATGEIFRADHLVEEVLEARLKGDKEARGQNSNDQPEESDDKKKRKKKVKEIRATRLDDKTVEEYEFILAQIDNYDGDQLGELMKKYDIRNPATNGELETPRQFNLMFETQIGPSGGLKGYLRPETAQGQFLNFSRLLEFNNGKVPFASAMVGKAFRNEISPRSGLLRVREFLMAEVEHFVDPKNKEHDRFDEVSHMPLRLLPRGVQLEGKTDILEMPIGDAVKKGIVDNTTLGYFMARISLFLEKIGIDMNRVRFRQHMSNEMAHYACDCWDAEIQCSYGWIECVGCADRSAYDLSVHSKATKTPLVVQEALPEPVVVEQFEVEVNRKKFGPRFKRDAKAVEEAMISWPESEKVEKSAQLVAEGKIIVNVNGVEHTVESDLVTIEKRKHTEHIRTYTPNVIEPSFGLGRILYVLMEHAYWTRPEDVNRGVLSFPASIAPIKALIVPLSRNAEFAPFVKKLSAKLRNLGISNKIDDSNANIGRRYARNDELGTPFGLTVDFETLQNETITLRERDSTKQVRGSQDEVIAALVSMVEGKSSFEDALAKFGEFKSTQE
What is the function of this protein?
Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP).  Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.  Thereby, may play a special role in Ap4A homeostasis.
What are the official names of this protein?
Putative glycine--tRNA ligase, Diadenosine tetraphosphate synthetase, Ap4A synthetase, Glycyl-tRNA synthetase, GlyRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AMPA_CUPPJ
Sequence: MEFSTKALDWSKAGQNGFLATKTDCLVVGVFEGQNLAGVAKALDVATKGLVARLLKQGDFEGKRGTQLTLHEVAGVGAARVLLVGLGKEADFNDKAFAEAVRTAVRALSSTRATSALWCLSQQPPQQRDIGWAVITTISLVRDAGYRLLERHPGLKRANGKPGAADKATLRKVVLAVDANDAKAATQAVVRGTAIANGMELTRDLGNLPSNICTPTYLANTARAIAKRHKLKVEVLGRKQIEALNMGSFLAVTKGSVEPPQFIVLRYDGAGAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTLQAVAEMGLKLNVIAVVPTCENMPSGVATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAAVVDVATLTGACIIALGHINTGLYARSDMLADQLLQAGRKSMDTAWRMPLDDEYQDQLKSNFADMANIGGRPAGSVTAACFLARFTEKYDWAHLDIAGTAWKSGAAKGATGRPVPLLTQFLMDRAA
What is the function of this protein?
Presumably involved in the processing and regular turnover of intracellular proteins.  Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
What are the official names of this protein?
Probable cytosol aminopeptidase, Leucine aminopeptidase, LAP, Leucyl aminopeptidase.
What is the protein family that this protein belongs to?
Belongs to the peptidase M17 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EHF_PANPA
Sequence: MILEGGGVMNLNPGNNLLHQPPTWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDASCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIVNTWKDENYLYDTNYGSTVDLLDSKTFCRAQISMTTTSHLPVAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN
What is the function of this protein?
Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation.  May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades.  Binds to DNA sequences containing the consensus nucleotide core sequence GGAA.  Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity).
What are the official names of this protein?
ETS homologous factor, ETS domain-containing transcription factor.
What is the protein family that this protein belongs to?
Belongs to the ETS family.
What are the subcellular locations of this protein?
Nucleus.
Protein: INSL3_RAT
Sequence: MHALLLLLLLALGSALRSPQPPEARAKLCGHHLVRALVRVCGGPRWSPEATQPVDTRDRELLQWLEQRHLLHALVADADPALDPDPALDPQLPHQASQRQRRSVATNAVHRCCLTGCTQQDLLGLCPH
What is the function of this protein?
Seems to play a role in testicular function.  May be a trophic hormone with a role in testicular descent in fetal life.  Is a ligand for LGR8 receptor (By similarity).
What are the official names of this protein?
Insulin-like 3, Leydig insulin-like peptide, Ley-I-L, Relaxin-like factor.
What is the protein family that this protein belongs to?
Belongs to the insulin family.
What are the subcellular locations of this protein?
Secreted.
Protein: RF3_PSYIN
Sequence: MTSKDIIENVEKRRTFAIISHPDAGKTTITEKVLLFGNALQKAGTVKGKKSGQHAKSDWMEMEKDRGISITTSVMQFPYKDRLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEQRTIKLMEVTRLRDTPIITFMNKCDRETRDPVDLMDEVEAILNIACAPITWPIGMGKEFKGIYDLLRDEVILYSSGQGHTIQEVRIIKGLDNPELESVLPNHIHDLREELELVVGASHQFDHELFLKGQLTPVYFGTALGNFGVDHVLDGLVEWAPKPLSRAAKQRVVEPLEDVFSGFIFKIQANMDPRHRDRIAFMRVCAGKYEKGMKMHHVRTGKMVSISDAVTFMAGDRTATEEAYPGDIIGLHNHGTIQIGDTFTSGETLKFAGIPNFAPEMFRRIRLLDPLKQKQLLKGLMQLSEEGAVQVFRPLRSNDLIVGAVGVLQFEVVVQRLKSEYKVDAIYEAISVATALWVESDNPLKMAEFEKKAYDNLALDGSNNLAYIAPTMVNLNLAMERYPDIRFRKTREH
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GUAA_YERPN
Sequence: MTKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSPESTIENGSPRAPDYVFTAGVPVLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSALIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVASTDTCPFAIMANEEKRFYGVQFHPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDSSVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALTGVDEPEAKRKIIGRVFVELFDEEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDFMTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing], GMP synthetase, Glutamine amidotransferase.
Protein: RDRP_I80A8
Sequence: MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSEKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHPGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMDKEEMEITTHFQRKRRVRDNMTKKMVTQRTIGKKKQRLNKRSYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLANIDLKYFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPFVSHKEIESVNNAVVMPAHGPAKNMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFFPSSSYRRPVGISSMVEAMVSRARIDARIDFESGRIKKEEFAEIMKICSTIEELRRQK
What is the function of this protein?
RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments.  The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching.  5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA.  In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs.  During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
What are the official names of this protein?
RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 1, PB1, RNA-directed RNA polymerase subunit P1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses polymerase PB1 family.
What are the subcellular locations of this protein?
Host nucleus. Host cytoplasm.
Protein: PANB_BACFR
Sequence: MAGYISDDTRKVTTHRLIEMKQRGEKISMLTSYDYTMAQIVDGAGIDVILVGDSASNVMAGNVTTLPITLDQMIYHGKSVVRGVKRAMVVVDMPFGSYQGNEMEGLASAIRIMKESHADALKLEGGEEIIDTVKRILSAGIPVMGHLGLMPQSINKYGTYTVRAKDDAEAEKLIRDAHLLEEAGCFGLVLEKIPAALASRVASELTIPVIGIGAGGDVDGQVLVIQDMLGMNNGFRPRFLRRYADLYTVMTDAISHYVSDVKNCDFPNEKEQY
What is the function of this protein?
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
What are the official names of this protein?
3-methyl-2-oxobutanoate hydroxymethyltransferase, Ketopantoate hydroxymethyltransferase, KPHMT.
What is the protein family that this protein belongs to?
Belongs to the PanB family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RAS1_CANAX
Sequence: MLREYKLVVVGGGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKQCTIDDQQVLLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSINSLNSFQELNSFYDQILRVKDSDNVPVLVVGNKCDLEMERQVSYEDGLALANSFNCPFLETSAKQRINVEEAFYGLVRNINQYNAKIAEAEKQQQQQQQQQNANQQGQDQYGQQKDNQQSQFNNQINNNNNTSAVNGGVSSDGIIDQNGNGGVSSGQANLPNQSQSQSQRQQQQQQQEPQQQSENQFSGQKQSSSKSKNGCCVIV
What is the function of this protein?
Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway.  The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity).
What are the official names of this protein?
Ras-like protein 1, Ras homolog type B.
What is the protein family that this protein belongs to?
Belongs to the small GTPase superfamily. Ras family.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor; Cytoplasmic side.
Protein: AMPPA_METMA
Sequence: MMQLKLEHYNIKIGQHKVLLNIVDAKELGVNPGDRVRIRGHQSLSAIVDTTDDMVPPGTLGVFTEVYEHFEDWDKPVEVVPSFRSKSAAVIKKMLDKKPVVQDEIKMLVSDIVDENLSDVELSAFITASYIHGMTDDEVEWLTRAMIDTGDTIEFDTHPIMDKHSIGGVPGNKISLLIVPIVAANGLLIPKTSSRAITGAGGTADLMEVLSPVEFSSQEVKEITEKVGGALVWGGATNIAPADDKLIKIEYPLSIDPYYQMLASIMAKKGAIGADNVVMDIPVGPGTKVPTVQEGQKLARDLINLGHRLGMNVECAITYGSSPIGRRVGPSLEVKEAMKVLESMEGPNSLIEKSAALAGILLEMGGAAPRDQGKELALETLRSGKALEKMKQIIEAQGGDPNIKSDDIQTGQYTADIFASTDGYVMEFDNKWIIEIARLAGAPNDKGAGVAIHKKRGEQVKKGDPILTIYAEKEIKLDNALATAQRTNPIIVEGMLLRRIPGTYGFQ
What is the function of this protein?
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P).  Exhibits phosphorylase activity toward CMP and UMP in addition to AMP.  Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
What are the official names of this protein?
AMP phosphorylase, AMPpase, Nucleoside monophosphate phosphorylase, NMP phosphorylase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Protein: GLGB_ECO24
Sequence: MSDRIDRDVINALIAGHFADPFSVLGMHKTTAGLEVRALLPDATDVWVIEPKTGRKLAKLECLDSRGFFSGVIPRRKNFFRYQLAVVWHGQQNLIDDPYRFGPLIQEMDAWLLSEGTHLRPYETLGAHADTMDGVTGTRFSVWAPNARRVSVVGQFNYWDGRRHPMRLRKESGIWELFIPGAHNGQLYKYEMIDANGNLRLKSDPYAFEAQMRPETASLICGLPEKVVQTEERKKANQFDAPISIYEVHLGSWRRHTDNNFWLSYRELADQLVPYAKWMGFTHLELLPINEHPFDGSWGYQPTGLYAPTRRFGTRDDFRYFIDAAHAAGLNVILDWVPGHFPTDDFALAEFDGTNLYEHSDPREGYHQDWNTLIYNYGRREVSNFLVGNALYWIERFGIDALRVDAVASMIYRDYSRKEGEWIPNEFGGRENLEAIEFLRNTNRILGEQVSGAVTMAEESTDFPGVSRPQDMGGLGFWYKWNLGWMHDTLDYMKLDPVYRQYHHDKLTFGILYNYTENFVLPLSHDEVVHGKKSILDRMPGDAWQKFANLRAYYGWMWAFPGKKLLFMGNEFAQGREWNHDASLDWHLLEGGDNWHHGVQRLVRDLNLTYRHHKAMHELDFDPYGFEWLVVDDKERSVLIFVRRDKEGNEIIVASNFTPVPRHDYRFGINQPGKWREILNTDSMHYHGSNAGNGGTVHSDEIASHGRQHSLSLTLPPLATIWLVREAE
What is the function of this protein?
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
What are the official names of this protein?
1,4-alpha-glucan branching enzyme GlgB, 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase, Alpha-(1->4)-glucan branching enzyme, Glycogen branching enzyme, BE.
What is the protein family that this protein belongs to?
Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
Protein: HMDH_PYRAB
Sequence: MNVEDIIEKVANGEIKLHQVEKYVNGDKRLATEIRRKALERKLGISLKHIGHYSIDPNELIGRNIENMIGVVQIPMGVAGPLKINGEYAKGEFYIPLATTEGALVASVNRGCSALTEAGGVVTTILDDKMTRAPLIRCPNARRAREVAEWVKENLNYLQEKAVAKVTRHGKLRDVKPFIVGNNLYLRFEFETGDAMGMNMVTIASEEIMKVIEEEFPDVRYLALSGNLCVDKKPNAVNFILGRGKTVVAEAIVPREIVEKKLKTTPELIAEVNYFKNLVGSAQAGSYGFNAHFGNIVGAIFLATGQDEAQITEGSHGITIAEVTPEGDLYISITMPSLEIGTVGGGTRVPTQREALSIMGVAGGGDPPGVNAKKFAEIVAGAVLAGELSLLAAIAAKHLARAHKMLGR
What is the function of this protein?
Converts HMG-CoA to mevalonate.
What are the official names of this protein?
3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase.
What is the protein family that this protein belongs to?
Belongs to the HMG-CoA reductase family.
Protein: ARLY_VIBCM
Sequence: MALWGGRFTQAADSRFKSFNDSLRFDYRLAEQDIVGSIAWSKALVSVNVLSVQEQQQLEQALNHLLQSVQQDPEQILASDAEDIHSWVEQKLIEQVGDLGKKLHTGRSRNDQVATDLKLWCRDQGVHLLLALKTLQQQLVAVAAEHQSTVLPGYTHLQRAQPVTFTHWCLAYLEMFERDESRLTDALARLNTSPLGSGALAGTAYAIDREVLAADLGFTRATRNSLDAVSDRDHVMELMSVASISMLHLSRLAEDMIFYTTGEAGFIELADTVTSGSSLMPQKKNPDALELIRGKTGRVYGALAGMMMTVKALPLAYNKDMQEDKEGLFDALDTWFDCLQMAGLCFDGIKVNAARTLEAAKQGYSNATELADYLVAKGIPFREAHHIVGVAVVAAIGKGVALEELCLAELQQFSPLIEQDVYPILTIESCLEKRCALGGVSPKQVAHALQQAQARVKS
What are the official names of this protein?
Argininosuccinate lyase, ASAL, Arginosuccinase.
What is the protein family that this protein belongs to?
Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GPI11_CANAL
Sequence: MPAAIRPMKKTVSFSKDVSNNNNNLESDSDTKQSPQSYLTFIPQIKNSLLVVPFHNIFILVGMFYSGLTQDLETVMWKGFLTSIPIQVIYNYIIYINLLPLKKSTRNDHQNNSSGSAINNNNNNNNNNVPLLIGSSIFVSIVLSLPLFVVIILMGAPVYKYSLKTLYLSLHLSQLIFNPLIILSNLNVNKIKRLFKQDHLYRIIFHHGILSSVLLTLGGCWLGVIPIPLDWDRPWQQWPITLLVGGYLGGVVGGVLSLIVNYFSH
What is the function of this protein?
Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
What are the official names of this protein?
Glycosylphosphatidylinositol anchor biosynthesis protein 11.
What is the protein family that this protein belongs to?
Belongs to the PIGF family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: TCAA_STAAS
Sequence: MKSCPKCGQQAQDDVQICTQCGHKFDSRQALYRKSTDEDIQTNNIKMRKMVPWAIGFFILILIIILFFLLRNFNSPEAQTKILVNAIENNDKQKVATLLSTKDNKVDSEEAKVYINYIKDEVGLKQFVSDLKNTVHKLNKSKTSVASYIQTRSGQNILRVSKNGTRYIFFDNMSFTAPTKQPIVKPKEKTKYEFKSGGKKKTVIAEANKVTPIGNFIPGTYRIPAMKSTENGDFAGYLKFDFRQSNSETVDVTEDFEEANITVTLKGDTKLNDSSKKVTINDREMAFSSSKTYGPYPQNKDITISASGKAKDKTFTTQTKTIKASDLKYNTEITLNFDSEDIEDYVEKKEKEENSLKNKLIEFFAGYSLANNAAFNQSDFDFVSSYIKKGSSFYDDVKKRVSKGSLMMISSPQIIDAEKHGDKITATVRLINENGKQVDKEYELEQGSQDRLQLIKTSEK
What is the function of this protein?
Plays a major role in decreasing resistance to glycopeptide antibiotics.
What are the official names of this protein?
Membrane-associated protein TcaA.
What is the protein family that this protein belongs to?
Belongs to the TcaA family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: HEM3_PROMP
Sequence: MTKFKLKIASRRSKLAMVQTLWVKEQLEKNIPDLEVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVHSLKDLPTNLPDGLTLGCITKREDPSDALVVNKKNKIYQLESLPPGSIVGTSSLRRLAQLRYKFPHLDFKDIRGNVITRIEKLDSGEFDCIILAAAGLKRLGFESRVHQIIPNEISLHAVGQGALGIECKSDDKEVLKIISVLEDKVSSQRCLAERSFLRELEGGCQVPIGVNSSIQNDEIALIGMVASIDGKRLIKNESIGNIKYPEEVGKKLAEKLKLQGADKILSEIFEQFRDK
What is the function of this protein?
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
What are the official names of this protein?
Porphobilinogen deaminase, PBG, Hydroxymethylbilane synthase, HMBS, Pre-uroporphyrinogen synthase.
What is the protein family that this protein belongs to?
Belongs to the HMBS family.
Protein: RL3_MARMM
Sequence: MRQEDRRTGVVARKLGMTRIFAEDGSHVPCTVLHMDNVQVVSHKTADRDGYVALQLGAGEAKAKRTPKAMRGHFAKAKVAPKRKLVEFRVAEDALIEVGSELTADHFVPGQKVDVAGISIGKGFAGAMKRHGFGGLRATHGVSISHRSHGSTGQCQDPGKVFKGKKMAGHMGAVRVTTQNIEVVRVDVERGIVLVKGAVPGSAGGWVELRDAIKGHGGTELPLPGKFRTLDELNAPVTAEVVENEAAPADADNAAPEAAADGEEGTQA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
What are the official names of this protein?
50S ribosomal protein L3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL3 family.
Protein: ISAB_STAA8
Sequence: MNKTSKVCVAATLALGTLIGVTVVENSAPTSKQAQAAITPYYTYNGYIGNNANFILDKNFINAIKYDNVKFNGIKLAKTNTIKKVEKYDQTFKGVSAKGNEASQLQFVVKNNISLKDIQKAYGKDLKKENGKTKEADSGIFYYQNAKKTLGIWFVVDHNRVVEVTVGHTPYKTSK
What are the official names of this protein?
Immunodominant staphylococcal antigen B.
What is the protein family that this protein belongs to?
Belongs to the IsaB family.
What are the subcellular locations of this protein?
Secreted.