PharMolix/UniProtQA huggingface dataset:
Protein: PMPB_CHLMU
Sequence: MSSMKWLSATAVFAAVLPSVSGFCFPESKELNFSRTGTSSSTTFTETIGENGTEYIVSGNSSFTNFTNIPVKKPTTDDSSTSTPTTSSAVDPTEKIVRASSSSSPNSGDTSATPDPKGGGAFYNEHSGILSFMARSGVEGSLTLSNIKMTGDGGAIYSQGELLFTDLTGLTIQGNLSQLSGGGIFGGSTISFSGINQATFSSNTAEVVPEETTPNPNPGTQTTTSQPSPTSKVQSLFTYSSSTQANGNGADSQTPSHKPGSGGAIYATGDLTISDSQEIVFSVNKASKDGGAIFAEKNVSFENITTLKVQNNGAEEKGGGIYASGDLSIQSSKQSLFNSNTSKQGGGALYIEGNVDFKDLEEIRIKYNKSGTFETKKVTLSLPEAQTNKSSVTAASQSGPNTTPTPTPPVTAKGGGLYTEKNLSISNITGIIEITNNKATDVGGGAYVKGTLTCKDSHRLQFQKNSSEKKGGGLYTEDTITLSNLTGKTLFQENTAKEEGGGLYIQGDDKTLTMTGLDSFCLIDNTSATHGGGAYVTKEISQTYTSDVEEFPGITPVHGETIISGNKATGGSGGGVCTKHLVLSNLQTISISENFASENGGGACTCPDNFPAPTASTPSTNQTAAPKDDKDFLIDYVVSTTIDKNKATKKGAGVYAKKAKLSRIDELNISDNAAQETGGGFCCTESLELDTIASLSVTKNLAGKEGGGLHAKTLNISNLKSGLSFSNNTANSSSTGVATTATTSQSPTVSSFLPRATAGSSPAPAQTTPTYAGVVGGAIYGETVSFSKCSGLCQFTENSAIDNTPSSPSLNVQGGAIYAKTSLSIEAEDPSTSYVFSKNSVSTGKAQTTGQIAGGAIYSPSVTLNCQTVFSGNSASMATTNPPSGTSPKDTIGGAIAGTTISLSKTSHFSENTADLGAAIGTLSGGSSSNLTEKITLSNGSFTFEKNKANKRGVIYAPSVSIKGNNITFNQNTSTHDGSAIYFTKDATIESLGSVLFTGNNVTAEQASSTATGGQTTNTTNYGAAIFGDPGTQTTDTTLKLIASSGNITFSNNSQNTATNNPATKFCSISGYVKLTLQAAQGKTISFFDSIRTSTKKTGQAQNSYETLDINKTENSNTYAGTVLFSSELHEVKSYVPQNVVLHNGTLVLKKNAELHVVSFEQKEGSKLIMEPGAVLSNQNIANGALAINGLTIDLSSLGAPQTGEVFSPPELRIVATTSNSGGGGGVGGYVTASKNLSAASPTVAATNPTMADNKVFLTGALTLIDPDGNFYQNPILGTDLTDVPLIKLPTTANQVDVSNLTLSGDLSPKKGYTGTWTLNPDPQTGKVVANWKFDMYRRWEYIPRDNHFYANSILGSQNSMIVVKQGLINNMLHNARFDDAAYNNFWVSGVGTFLSQQGTPLSEEFSYYSRGTSVAIDAKPRPDFILGAAFSKMVGRTKAIKKVHNYSHKGSEYSYQASVYGGKFLYFLLNKQHGWALPFLLQGVVSYGHIKHDTTTLYPSIHEKNKGDWEDLGWLVDLRVSMDVKEPSKRSSKRVALYGELEYSSIRQKSFTEIDYDPRRFDDCAYRNLSIPMGCYFEGAIMSYDILMYNKLSLAYMPSIYRNNPVCKYWVLSSNETSKVVCGVPTRTSARAEYSTQLYLGPFWTLYGNYTIDVGMYTLAQMTSCGARMIF
What are the official names of this protein?
Probable outer membrane protein PmpB, Polymorphic membrane protein B.
What is the protein family that this protein belongs to?
Belongs to the PMP outer membrane protein family.
What are the subcellular locations of this protein?
Secreted, cell wall. Cell outer membrane; Peripheral membrane protein; Extracellular side.
Protein: RS8_SULSY
Sequence: MITDPIADMIARINNAIKARKDEVSVPTSKIKEQLSEILKREGYIEDYVVSEENKKGNQGTLIIKLKYLGRRNTKPAISKIQRVSKPGLRKYVSVDEMPYVQKGLGIAILTTNKGIMTDSEARKQRLGGEIICYVW
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: PUR2_RHILO
Sequence: MNVLLLGSGGREHALAWKIAASPLLTKLYAAPGNPGIGAEAELVKLDITDHAAVTAFCQEKKIDLVVVGPEGPLVAGIADDLRAENIRVFGPSKAAARLEGSKGFTKDLCARYNIPTAAYGRFNDLASAKAYVDQTGAPIVIKADGLAAGKGVTVAMTSDEARAALDACFEGSFGAAGAEVVVEEFMTGEEASFFCLCDGTTALPFGTAQDHKRVGDGDVGPNTGGMGAYSPAPVMTPEMIERTMREIIEPTMRGMAELGAPFAGILFAGLMITDKGPKLIEYNTRFGDPECQVLMMRLKDDLLVLLNAAVDGQLAHTSIRWRDEAALTVVMAARGYPGTPEKGSVIRGVEQAAGEGVQIFHAGTAINGGALVANGGRVLNVTASGATVGEAQKRAYAALDRIDWPDGFCRRDIGWQAVARERAS
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: AAS_KLEP7
Sequence: MLLGFFRLLFKGLYRVRLTGDTQALYQQKVLITPNHVSFLDGILLALFLPVRPVFAVYTSISQRWFMRALTPIIDFVPLDPTKPMSIKHLVRLIEQGRPVVIFPEGRISVSGSLMKIYDGAAFVAAKSQATIVPLRIEGAELTPFSRLKGLVKRRLFPRIQLHLLPPTHLPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQDRFGARKPCVEDINFQPDTYRKLLTKTLFVARILEKYSQPGEKIGLMLPNAGISAAVIFGAIARGRIPAMMNYTAGVKGLSSAIAAAELNTIFTSRTFLDKGKLWHLPEQLTQVRWVFLEDLKGDITLADKLWIFAHLLAPRLAQVKQQPEDAAMILFTSGSEGNPKGVVHSHKSLLSNVEQIKTIADFTANDRFMSALPLFHSFGLTVGLLTPLLTGAEVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLANYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKVGTVGRILPGMDARLLAMPGIDQGGRLQLKGPNIMKGYLRVENPGVLEAPAAENQHGEMEAGWYDTGDIVTFDEQGYVRIQGRAKRFAKIAGEMISLEMVEQVALGASPDKMHATAIKQDASKGEALVLFTTDNELTREALLRYARQHGVPELAVPRDIRWLKQLPVLGSGKPDYVTLKNMVDEAETTHE
What is the function of this protein?
Plays a role in lysophospholipid acylation.  Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium.  Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
What are the official names of this protein?
Bifunctional protein Aas.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HTPG_BUCAI
Sequence: MKTQKKEVYNFQSETKKLLHLMIHSLYSNKEIFLRELISNSSDAIDKLRFESISSPELYENDSDVKIQISINKAQRTLIISDNGIGMTKEDTIENLGTIAKSGTKSFLQSLEQKQNKKNELIGEFGVGFYSSFIVSEKVSVRTRFAGLESNKGILWESSGEGEYNITNIVKKTRGTEITLFLKKEEEEFLETWRIKNIISKYSDHITIPIHIQDYDKKNKTYFWEQINKAKALWTLNKSSITEEEYKDFYKHLTNDQNDPLIWSHNHVEGNQEYISLLYIPEKAAWDIWNRDNKHGLKLYVKRVYIMDNSQAFLPNYLRFIKGLIDSSDLPLNISREILQDNSITEKLRKSLIKKSLSMLEKLAQKNNEKYQIFWNQFGLVLKEGPAEDHENLNKIANLLRFTSMKSNNSEQKMSLKEYISNMNEQQEKIYYITADSYSSANNSPHLELFKKNNIDVLLLSDRIDEWMMNYLSEFEGKKFQSISKEDISLNKLTKEKKIKNKDVSTEMIEFLKKVKNILGNQVKDVRLTHRLTETPCVLLSDSTEMTTQMAKLFSAAGQSVPELKYIFEINPDHILIKKICTINNENELHQWIKLLLDQALLAEKGNLENPHKFISRMNKLLIK
What is the function of this protein?
Molecular chaperone.  Has ATPase activity.
What are the official names of this protein?
Chaperone protein HtpG, Heat shock protein HtpG, High temperature protein G.
What is the protein family that this protein belongs to?
Belongs to the heat shock protein 90 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: GLNA2_STRCO
Sequence: MDKQQEFVIRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEQAFDEGIGFDGSAIEGFARVYESDMIAKPDPSTFQVLPWRAEAPGTARMFCDILMPDGSPSFADPRYVLKRALARTSDLGFTFYTHPEIEFFLLKDKPVDGSVPTPADNSGYFDHTPQNIGMDFRRQAITMLESMGISVEFSHHEGAPGQQEIDLRYADALSTADNVMTFRLVMKQVALEQGLQATFMPKPFSEYPGSGMHTHLSLFEGDRNAFYESGAEYQLSKVGRSFIAGLLRHAAEISAVTNQWVNSYKRIWGGTERTAGAGGEAPSYICWGHNNRSALVRVPMYKPGKTGSARVEVRSIDSGANPYLTYAVLLAAGLKGIEEGYELPPGAEDDVWALSDAERRALGIEPLPQNLGEALALMERSDLVAETLGEHVFDFFLRNKRQEWEEYRSQVTAFELRKSLPVL
What is the function of this protein?
Involved in the catabolism of polyamines.  Catalyzes the ATP-dependent gamma-glutamylation of polyamines.  Substrates include putrescine, cadaverine, spermidine and spermine, with a preference for short-chain polyamine putrescine (PubMed:35409114).  No complementation of the L-glutamine auxotrophy of an E. coli glnA mutant (PubMed:16932908).  Together with GlnA3, enables survival of S. coelicolor under exposure to high local environmental polyamine concentrations, which is toxic to the cells (PubMed:35409114).
What are the official names of this protein?
Gamma-glutamylpolyamine synthetase GlnA2.
What is the protein family that this protein belongs to?
Belongs to the glutamine synthetase family.
Protein: RL14_HYDCU
Sequence: MIQMQTVLDVADNSGARKVQCIKVLGGSKRRYASVGDVIKVAVKEAAPRGKVKKGDVFDAVVVRTAQGVRRPDGSKIKFDGNAAVILNTKLEPIGTRIFGPVTRELRNDKFMKIVSLAPEVL
What is the function of this protein?
Binds to 23S rRNA.  Forms part of two intersubunit bridges in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.
Protein: RF3_LISMF
Sequence: MSQDLQKEVASRKTFAIISHPDAGKTTITEQLLLFGGVIRSAGTVKGKKSGKFATSDWMEIEKQRGISVTSSVMQFDYNGSRINILDTPGHSDFSEDTYRTLMAVDSAVMVIDAAKGIEAQTLKLFKVCRMRGIPIFTFINKMDRQGKMPLELLAELEEVLGIESYPMNWPIGMGKELAGLYDRYHRVIEQYRSEEDERFLPLGEDGDLKEAHAIQKSLYYDQALEEIMLLDEAGNDFSRERIIAGEQTPVFFGSALTNFGVETFLRTFVDFAPSPSSHESNEGVIEADNPKFSGFIFKIQANMNPAHRDRIAFIRICSGEFERGMNVTLTRTGKSMKLANSTQFMADDRETVNRAVAGDIIGLYDTGNYQIGDTITNGSKKLEFEKLPQFTPELFMRVYAKNVMKQKHFHKGVEQLVQEGAIQLFKTWRTEEYIIGAVGQLQFEVFEHRMRGEYNSEIRMEPIGKKIARWVKEEDADEKLSTARSMLVKDRFDQPLFLFENEFAINWFNDKNPDIELTSLL
What is the function of this protein?
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2.  It binds guanine nucleotides and has strong preference for UGA stop codons.  It may interact directly with the ribosome.  The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
What are the official names of this protein?
Peptide chain release factor 3, RF-3.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL32_VARPS
Sequence: MAVQQNKKSPSKRGMHRSHNALVVPGIAVEPTTGETHLRHHISPNGFYRGRQVLKNKSEA
What are the official names of this protein?
50S ribosomal protein L32.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL32 family.
Protein: HRCA_SYNJA
Sequence: MKLELTPRQRKILWATVRRYIATAEPVGSKTLAQSYNLGVSTATIRNDLATLEQVGLLFQPHTSAGRIPSDFGYRVYVNDLLSSANMDGIPNDAPQPEPHPALQQLLDQLNRELGDDLDSFLQRVAQLLAHLSGCIALITPPQGPVVAVHHVQLLSVGPGRVMVLVVTDSYQTHSALVSPPDWPDDRREDLEDELQLLSNFLTLKLRGKTFAELQDLSWLKLDEEFRAYSHWLQQLLRSVVQRYLRPSLGQVFSAGMTELMRQPEFSQAQRMQAVAQLLEEGSEQLQGMIGLYSTPGCLFTSEAALSAPSAREKASSSTADQDPSHNVPVIIYIGSENPLESLHHCTVIASVYRRRSAPLGTVTLLGPTRMAYERSIAAVQTVASHLTRALA
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: SYCP2_RAT
Sequence: MPVRPDPQQLEKCIDDALRKNDFKPLVTLLQIDICEDVKIKCSKQFLRKLDDLICRELHKKDIQTISNILISIGRCSKNIFILGQTGLQTMIKQGLVQKMVSWFENSKEIILSQRQSKDEAVMNMIEDLFDLLMVVYDVNDEGKNQVLESFIPHICALVIDSRVNFCIQQEALKKMNLMLDRIPQDANKILCNQEILTLMSNMGERILDVGDYELQVGIVEALCRMTTEKRRQELAYEWFSMDFIANAFKKIKDCEFETDCRIFLNLVNGMLGDRRRVFTFPCLSAFLGKYELQIPSDEKLEEFWIDFNLGSHTLSFYIAGDDDDHQWEAVTVPEEKVDMYNIEVRESKKLLTLTLKNIVKISKKEGKELLLYFDAALEITNVTKKLFGGNKYKEFTRKQDISVAKTSIHVLFDASGSQILVPESQPSPVKENLIHLKEKSNLQKKLTNPLEPDNSSSQRDRKNSQDEITTPSRKKMSEASMIVPDTDRYTVRSPILLINTSTPRRSRAPLQAIHSAEKAVSKTSESGVDYAVSLKSRQSDGRNRGNNRANHNKTATVQNKGHEHHESPDQTFNEIEETLSDAYAVEKVDKPVLPGVLDISKNKAHSRWACWTPVTTIKLCNNQRSCALPGDTFTQDTGVNKKCTKQKSVSDDDSEETQRVKYSKDVIKCNKSEEAEVCERNIQEQNHPKYSQKKNTANAKKNDWHIESETTYKSVLLNKTTEESLIYKKTCVLSKDVNTTICDKSPSRKSMRSHTKSRKELMSEVTSCELDEIPVRENSKGKRFTGTAESLINLINKRYNSSDDMISTRKLKEPRDGSGFSKKPELQFNKVQRKSYRKLKTVVNVTSECPLNDVYNFSLNGADEPVIKLGIQEFQATTREASMDNSIKLVDVRNRDERDLSLKTKDERILSHERKTLFSDTETECGWDDSKTDISWLRKPKSKRLMDYSRNKNTKKCKSIKSRSSTEKGQPRSTVVLSKNIAKNDYEVIVDGRTRLPRRATKTKKNYKDLSTSGSESESEKEISYLFKDKLPTKEETVHSSAQTKKLPKKQQKVFNTEALKGQPSEEQKNSSTLRNGREDSLYLSSASVSGSSSSVEVMRCTEKITERDFTQDYDYITKSLSPYPKAASPEFLNRSNRVVGHGKSPRISETSAVCVRKSCSPASGLPFSPRHTTKNNSVMNIKNTNSVINNQRTQHCNSYSDVSSNSSEKLYMEPESPDSCENHVQSKREENHAASPFSLSSEKIEKIWFDMPNDNTHVSGPSQRGSKRRMYLEEDELSNPSEAEVQEAEEREHLVSKKLCQREHFDQHTSETSLSTPEFSVPKDWQQELQGAGMFYDNINSDYKRKTDTQHKIMDDFTTKTLKLTQQHLLAMACQARGHRDENIDKFQVTLLDELEKVEKDSQTLRDLEKEFVDIEEKIVHKMRAFHQSERERFRALKTSLDKSLLVYNSVYEENVLTSEMCLMKANMKMLQDKLLKEMHEEELLNIRRGLESLFKDHEGNNA
What is the function of this protein?
Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase (PubMed:9592139, PubMed:9933407).  Plays a role in the assembly of synaptonemal complexes.  Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.  Required for insertion of SYCP3 into synaptonemal complexes.  May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions.  Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.
What are the official names of this protein?
Synaptonemal complex protein 2, SCP-2, Synaptonemal complex lateral element protein, rnSCP2.
What is the protein family that this protein belongs to?
Belongs to the SYCP2 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes.
Protein: RNH2_HELPG
Sequence: MILGIDEAGRGCLAGSLFVAGVACDDQTALEFLKMGLKDSKKLSPKKRFFLEDKIKTHGEVGFFVVKKSANEIDSLGLGACLKLAVQEILENGCSLANEIKIDGNTAFGLNKRYPNIQTIIKGDEKIAQIAMASVLAKAFKDREMRQLHALFKEYGWDKNCGYGTKQHIEAISKLGATPFHRHSFTLKNRILNPKLLEVEQRLI
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPSD_TASV1
Sequence: MSAPAGKAGPKAQKKCKVVTQKTKTVPKKTKQQKPRKVRLQKVERQVKTLKAKTRGPKISDTFSTVVTVGRIIGNNDDSLTRQLKVFVNPLLMKNQDSGSTSSPLSIRASQYGLWKIAKLHVYFTPLAGSANVIGTVSFASLEQESGVATAESPDTIKAKYHAEVPIGSRFVWKVPPRMLTGPREGWWNMDSGDDPTNSVGPSISFWTYLKTILALSTATTTSYLGSLFLIEIRCTYLFSNYAPKPNLAIMVNEKITTTQPVTLTNLSDGSLVMTTTDTRLCALLDNDRGPRGPNAQTNGPGEKFWAVSTLVVDTVAASIGPWGWLLKGGWWVIRKIFGAANTTSTYAIYASVEDAAKDSRIYQPVSGTQTLAAGDVYVTQLTQPNVNEAGSTSLGFSPPTPPAPTGSYLPLPQAAGVPGIPPQYTFSDGQYTAATTWSGTQLYLTGVPATKTVSGSNEMFGVENNTMSRANIDRVQIYDFTTTGIIFLGGQNRSGGAIHTAKTLIVALKTATTKAPWLAADATGTNWAMPSWVGFPVPGAGDHFLQMQNSTDRTTHTTPVGVYFLVAYGATNKLVAFWAAPTDVQAEPTSLMTLYNVDAGRAPITAGLNFTTAMTEYSDDDDDAESDISSLFAPDEVDWKFKIEASSSRHLEEELQFWKSKATQLMLEKN
What is the function of this protein?
Capsid polyprotein VP90: self-assembles to form an icosahedral T=3 capsid.
What are the official names of this protein?
Capsid polyprotein VP90.
What is the protein family that this protein belongs to?
Belongs to the astroviridae capsid polyprotein family.
What are the subcellular locations of this protein?
Virion.
Protein: SYS_SHEB8
Sequence: MLDPKFLRNELEVTAERLATRGFILDIAHLTQLEEKRKSLQVATEELQASRNAISKSIGQAKARGEDVEAIMAQVGDLGSQLDAKKIELAAVLEEVNAIAMSMPNLPDESAPIGADETENVEVRRWGTPRTFDFPIKDHIDLGEGLNGLDFKNAVKITGSRFIVMKGQVARLNRAIGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPLTNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPEDSMAALEALTGHAETVLQRLGLPYRTVILCTGDMGFGSSKTYDIEVWLPAQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSITIPEVLRPYMGGLTQIG
What is the function of this protein?
Catalyzes the attachment of serine to tRNA(Ser).  Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
What are the official names of this protein?
Serine--tRNA ligase, Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM39A_HUMAN
Sequence: MPGGRRGPSRQQLSRSALPSLQTLVGGGCGNGTGLRNRNGSAIGLPVPPITALITPGPVRHCQIPDLPVDGSLLFEFLFFIYLLVALFIQYINIYKTVWWYPYNHPASCTSLNFHLIDYHLAAFITVMLARRLVWALISEATKAGAASMIHYMVLISARLVLLTLCGWVLCWTLVNLFRSHSVLNLLFLGYPFGVYVPLCCFHQDSRAHLLLTDYNYVVQHEAVEESASTVGGLAKSKDFLSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVECLKADFNHRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCEHLIMVWINAFVMLTTQLLPSKYCDLLHKSAAHLGKWQKLEHGSYSNAPQHIWSENTIWPQGVLVRHSRCLYRAMGPYNVAVPSDVSHARFYFLFHRPLRLLNLLILIEGSVVFYQLYSLLRSEKWNHTLSMALILFCNYYVLFKLLRDRIVLGRAYSYPLNSYELKAN
What is the function of this protein?
(Microbial infection) Positively regulates the replication of encephalomyocarditis virus (EMCV) via autophagy-dependent pathway.
What are the official names of this protein?
Transmembrane protein 39A.
What is the protein family that this protein belongs to?
Belongs to the TMEM39 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: CYSD_MYCBP
Sequence: MTSDVTVGPAPGQYQLSHLRLLEAEAIHVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNFDEVIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAEQVRLPSIYFAHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFRTVGDVTCTGCVESSASTVAEVIAETAVARLTERGATRADDRISEAGMEDRKRQGYF
What is the function of this protein?
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway.  APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
What are the official names of this protein?
Sulfate adenylyltransferase subunit 2, ATP-sulfurylase small subunit, Sulfate adenylate transferase, SAT.
What is the protein family that this protein belongs to?
Belongs to the PAPS reductase family. CysD subfamily.
Protein: RPN1_ENCCU
Sequence: MEEGELKIIVERIQDPDIDIQNNALNMLFDVTKSSHSKSIDTINFQYLADNLDVLEDVCKRLEGNKKRWLCDIISAICVVDDERKLLAYRVEGNIIDLKEWGHLYVKKLIGCIADVKNNKMDFPFAKTRDVGRECIDFLFKHNAEFEAIDFLVEVGGIETVLDYVDTHNYNRIVLYLEDMNSFVDLEEVILKIYLKMGDHSRYVVGLIRRQKSKEAIEYVRSIEDRDYKKQCLYILARCNLYYEASDPEEKYILSNGYIKDVYREIGAELEIDKPSKMDAILKGFKYDKDTRQLASIGIANGFVHMGYGRDPIFLPQEGDSRVPLDYEAILGCDVPDLISVFGSIGVIESWNSEKVMETLQEHIFADFSYRKTGSLLGLALSGLRNFEERPAILALLSNNLQSSSSIHVIATLLGIEAMFSGTQAEEVRELLQPLMFSDSSEVVFFTSFTLGSVFCGSADEDLTSLMLQTFVEKGKESETQFFRFLMLGLASLFYRRKDVECGIMEIGGALSKHESILIKGFQYVGTGDSNVIESILTDSFTGDTDALLESLGLLSCALVSMGDETSSQMVGRIVSSSLLLDSSHLRSVLPLCYSILYPSNPQVNVLDMLEKSLNIGETNCIISTIVSLGLIGAGTLNSRITKILDQQYSYYYKDSKVLPVLKIAQGLVSLGKGLLSISPLYFDKTTFMPKNTIGLFSTVFMLLDSSISPLVSSHAYMFFLLCQACTQKYVTCSEKINIRVGHPINTVGMVGEPKKLSSVQTHTSPVVLSEKIRAETDENVCSSYIEDVLILKKN
What is the function of this protein?
Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus.  It is essential for the regulated turnover of proteins and for the removal of misfolded proteins.  The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).
What are the official names of this protein?
26S proteasome regulatory subunit RPN1.
What is the protein family that this protein belongs to?
Belongs to the proteasome subunit S2 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: PB2_I75A3
Sequence: MERIKELRNLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRITEMVPERNEQGQTLWSKMSDAGSDRVMVSPLAVTWWNRNGPVTSTVHYPKVYKTYFDKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQDCKISPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDIDQSLIIAARNIVRRASVSADPLASLLEMCHSTQIGGTRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSIKREEEVLTGNLQTLKIRVHEGYEEFTMVGKRATAILRKATRRLVQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWGIEHIDNVMGMVGVLPDMTPSTEMSMRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETHGTERLTITYSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQNPTMLYNKMEFEPFQSLVPKAIRGQYSGFVRTLFQQMRDVLGTFDTTQIIKLLPFAAAPPKQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKTTKRLTILGKDAGTLIEDPDESTSGVESAVLRGFLILGKEDRRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN
What is the function of this protein?
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.  Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA.  Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.  In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.
What are the official names of this protein?
Polymerase basic protein 2, RNA-directed RNA polymerase subunit P3.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses PB2 family.
What are the subcellular locations of this protein?
Virion. Host nucleus. Host mitochondrion.
Protein: Y1848_STRZT
Sequence: MKLPKEGDFITIQSYKHDGSLHRTWRDTMVLKTTENAIIGVNDHTLVTESDGRRWVTREPAIVYFHKKYWFNIIAMIRDNGTSYYCNMASPYYLDEEALKYIDYDLDVKIFTDGEKRLLDVEEYERHKRKMNYSDDLDYILKEHVKILVDWINNGRGPFSEAYVNIWYKRYVELKNR
What are the official names of this protein?
UPF0374 protein SPT_1848.
What is the protein family that this protein belongs to?
Belongs to the UPF0374 family.
Protein: GGYF2_XENLA
Sequence: MTAETQTLNFGPEWLRALSSGGSVISPPLSPALPKYKLADFRYGREEMLALYVKDNKVPSDLLDKEFLPILNDEPLLPLALVSFTEEEQRNFSMSVNSAAVLRLTNRGSSGGGGTVVGVPRGRSSSRGRGRGRGESGFYQRSFDEVESGFGRGAREMHRSQSWEERGDRRFEKPARKEPDGVRGSAWREIPDRRRRFDYDLRESKDERGYRRPRSGSGIAEDERDSLPEWCLDDAEDETGTFDSSGAFLSSKPSKKVQKEPIPEEQEIDFHPSVDGAEVSDSDGSQTEEAKETDPVQSQNQDDDLSRNDHTVQAAPSPDHKTSSPVRRTDMTLDTAHQKAVSPHLSCKMDAKSQSPSSPPTPSKHKEDAASASHQGTREKAGPCLPHPQSPALSQRSPARQPDPHIVPAMSSVPVPQLDTPTVPIHSSVCAAPGMEPVPPEPDEDGLEHLEQQAQQMVAYLQDGTLDDDHLLTKVLDQRVKGPSLDNQQKWYYKDPQGEIQGPFSNREMAEWYQAGYFPMTLLLRRVCDETFQPLGDIFKKWGRVPFSTPPTPRLGDLDPERLSRQQEITALYQMRHLHYQQLLFQQQYAVLAQQQKVALSSQQQQLPLPLQPLSMRIPEHTVIPPVVRALSVPESTSLWELPPAPTQPAVWEGSSVWDLPVEPTTQGTTREQLAQMDKVKAAKMEQERREAELRAKQEEEEQHRRKEAEEERKRREEEELARRKQEEALQRQKELALQKQMEEEERQRKKELQLLEERMRQEEERKRLEEERRRQEEERRKQLEERKRAEEERRRREEEKKREEDERRQLEEIQRKQEEAARWAREEEEAVRLLLEEARLKAEEEERNKREEAQRQKELQRQRQQQQEALRRLQLQQQQQQLAQMKLPSSSTWGQQVTPSAASQSALSLAEIQKLEEERERQKLQEQRHQQQELKALQQQQQQQQQKIPGWGTMSKPTGTTKSLLEIQQEEAGQMQKNHQQPGRNRPANISLPVAPVVNNHISSPTVGNSGSSVWGSLNNNLSPQWSSDSMSSIWGSTDVKGSSVGFWDDAVKEVAPRNATSKNKNNASKSAGSNSRQSKKVEQEEKLLRLFQGANKCQDDFTQWCEKTMHAINTAHSLDVPTFVSFLREVESPYEVHDYVCAYLGDTPEAKDFSKQFIERRTKQKTSQHRPQQDVAWVTCQTSQANSQPITLEAVQCAGRKKKKQKMVRADPSLLGFSVNASSERLNMGEIETAEDY
What is the function of this protein?
Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.
What are the official names of this protein?
GRB10-interacting GYF protein 2, PERQ amino acid-rich with GYF domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the GIGYF family.
Protein: IF2_MARMM
Sequence: MSDADDNNSSGRRPLSLKRSGGGTVQQSFARGRSKAVVVEKKRKRVATPAKDGGPGGKQGGGAKGGESALAAKARQLGLSEEELVARQRAIARARAEAADREAQKKQDAAAMAQRAASEQRQLEEQRERVAREAREAEEAAQKAIEDEARLKAEAEAATAAKDSGRKRDDESSRRRPPAKDEKRTPEVVPMDEASALEALGGRVKRKGGAAGPGPAAKQQPARAKTDNRRRGKLTIQNILEGDEERQRSLASVRRAREREKQRRQDTSGGREKIEREVVVPEAITVADLANRMAERSVDVIKYMMKQGQMVRMNDVLDADTAELVVEDFGHIVKRVSEADVEQGFIDDDDADEAKLPRAPVIAVMGHVDHGKTSLLDALRSTDIASGEAGGITQHIGAYQVELKGGQKITFLDTPGHAAFSAMRSRGAMATDIVILVVAADDSVKPQTIEAIHHAKAAGTPIIVAVNKCDKHEANPQKVLTDLLQHEIVVEAMSGEVQSVNVSAKTREGLDELTEAIALQAELLDLKANPERSAEGIVIESQVDKGRGPVATLLVRRGTLKRGEIVVAGAQWGRVRALVDARGQQLPEAGPSLAVEILGLDGAPDPGELFAVVDSESRAREIADYRQRKGREATGGSSPASASLEQMMARLKQDETQEMPLLVKSDVQGSAEAIKQSLEGIGNDEVRARIIRAAPGGVNESDVLLAKSSGAPVFAFNVRANKQARELAEREGVEIRYYSVIYDVIDDVRNTMEGMLAPEKRENFIGYAEILEVFNITKTGKVAGCRVTEGVVRRGCGVRLLRDDTVLHEGKLKTLKRFKDEVSDVRAGTECGMAFEKYEDLRKGDQIECFEVIEVARKLEA
What is the function of this protein?
One of the essential components for the initiation of protein synthesis.  Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits.  Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
What are the official names of this protein?
Translation initiation factor IF-2.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.