PharMolix/UniProtQA huggingface dataset:
Protein: FANCI_MOUSE
Sequence: MDLKILSLATDKTTDKLQEFLQTLKDDDLASLLQNQAVKGRAVGTLLRAVLKGSPCSEEDGALRRYKIYSCCIQLVESGDLQQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDRLVNGKSLELLPIILTALATKKEVLACGKGDLNGEEYKRQLIDTLCSVRWPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLTMFSKLNLQEIPPLVYQLLVLSSKGSRRSVLDGIIAFFRELDKQHREEQSSDELSELITAPADELYHVEGTVILHIVFAIKLDCELGRELLKHLKAGQQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKDLQLLQGSKFLQTLVPQRTCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSYGPKKILDGKAVEIGTSLSKMTNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLILQNCSKVTETFDYLTFLPLQTVQGLLKAVQPLLKISMSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKVLGSLPSSQCTQSIGVTQVRVDVHSRYSAVANETFCLEIIDSLKRSLGQQADIRLMLYDGFYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGACVLTQGSQIFLQEPLDHLLSCIQHCLAWYKSRVVPLQQGDEGEEEEEELYSELDDMLESITVRMIKSELEDFELDKSADFSQNTNVGIKNNICACLIMGVCEVLMEYNFSISNFSKSKFEEILSLFTCYKKFSDILSEKAGKGKAKMTSKVSDSLLSLKFVSDLLTALFRDSIQSHEESLSVLRSSGEFMHYAVNVTLQKIQQLIRTGHVSGPDGQNPDKIFQNLCDITRVLLWRYTSIPTSVEESGKKEKGKSISLLCLEGLQKTFSVVLQFYQPKVQQFLQALDVMGTEEEEAGVTVTQRASFQIRQFQRSLLNLLSSEEDDFNSKEALLLIAVLSTLSRLLEPTSPQFVQMLSWTSKICKEYSQEDASFCKSLMNLFFSLHVLYKSPVTLLRDLSQDIHGQLGDIDQDVEIEKTDHFAVVNLRTAAPTVCLLVLSQAEKVLEEVDWLIAKIKGSANQETLSDKVTPEDASSQAVPPTLLIEKAIVMQLGTLVTFFHELVQTALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVCQSSRGIPNTVEKLVKLSGSHLTPVCYSFISYVQNKSSDAPKCSEKEKAAVSTTMAKVLRETKPIPNLVFAIEQYEKFLIQLSKKSKVNLMQHMKLSTSRDFKIKGSVLDMVLREDEEDENEEGTASAHTQQDREPAKKRRKKCLS
What is the function of this protein?
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites.  Required for maintenance of chromosomal stability.  Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA).  Participates in S phase and G2 phase checkpoint activation upon DNA damage.
What are the official names of this protein?
Fanconi anemia group I protein homolog, Protein FACI.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges (By similarity).
Protein: TATA_ACTP7
Sequence: MGGISIWQLLIIVAIIVLLFGTKKLRTLGTDLGESVKGFKKAMADDKSQPQDASFEKVEAKEAASTEQKAKEKEQA
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: WTF33_SCHKA
Sequence: MKNKYYPLRSSMDELSTKNDNEIDLEKGPLPEYNSEDGSTLPPYSENLNLKDPKQMGANNPNLFNTDESTTPPDYGEDSLSTTHRENHSSGTADNSCASTLKKAILSFIPIFVLNVSAVCYLTYKDALFKDYGKDEWVYFGMWCASCLMILISLWCFYETWIKAVKVTAVFLAQCIKVTAVFLPQCIKVTAVFLAKCVKVTAVFLAKCIKVTAVFLAQCVKVTAISLAKCVKVISIGLFNIRREMMIIIWILWLIICCILFGCVKDGRLNFNKALICSTCTISAVLFLIVSSVCIPIWTLWRALSGMLQVLGIHGIIAVLVNGSMSLFGKHFGWRGYEIEGFVLFFTSSALFLYEMERPGVLKRMRNTTGNVIGYICGVIGDAFRRIENAFRGANDNNNIPLGEMDVEGEV
What is the function of this protein?
Forms toxic aggregates that disrupt spore maturation.
What are the official names of this protein?
Meiotic driver wtf33.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
[Isoform 1]: Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Contained within spores expressing the isoform and localizes isoform 2 to the vacuole. SUBCELLULAR LOCATION: [Isoform 2]: Ascus epiplasm. Cytoplasm. Spore membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localizes in trans to all spores within an ascus. Localization to the spore vacuole is dependent on isoform 1.
Protein: KTNB1_XENLA
Sequence: MAAPSPTKTTWKLQEIVAHGCSVSSVVLGRSSGRLVATGGDDCRVHLWSVNKPNCIMSLTGHTTPVESVRFNNSEELIVAGSQSGSLRIWDLEAAKILRTLMGHKANVSSLDFHPYGEFVASGSLDTNIKLWDVRRKGCVFRYKGHTQAVRCLRFSPDGKWLASASDDHSVKLWDLTAGKMMAELSEHKGPVNIIEFHPNEYLLASGSADRTVRFWDLEKFQLVGCTEGETIPVRAILFSNDGGCIFCGGKDSLRVYGWEPDQCFDTVPVGWGKVSDLAICNNQLIGVSSAQSNISSFVVDLTRVKMTGCAPQGPVPAEIPISQPAPTGTSLRRIYERPSTTCSKPNRVSPTSDDEEKESRAEIQNPEDYKEIFQPKNAISRTPPRNSEPFPAPPEDDISIVKEAVAPTPDVVTPATSNKKNTEQLQRPPVAASTPIVCQEPSPVPAPQSKPPVISAARNEPIGLKAADFLPAVKSSSPTEVVDDEAVSQIRKGHDTMCMVLTSRMRNLDTVRAVWSSGDIKTSIDSAVAINDLSVVVDLLNIINQKASLWKLDLCMTVLPQIEKMLQSKYESYVQTGCISLKLILQRFLPLITDILAAPPSVGVDISREERLSKCKLCYKQLRILSPLVKSKASQSGRYGSAFRELHLLMSGLE
What is the function of this protein?
Participates in a complex which severs microtubules in an ATP-dependent manner.  May act to target the enzymatic subunit of this complex to sites of action such as the centrosome.  Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.
What are the official names of this protein?
Katanin p80 WD40 repeat-containing subunit B1, Katanin p80 subunit B1, p80 katanin.
What is the protein family that this protein belongs to?
Belongs to the WD repeat KATNB1 family.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.
Protein: FUMC_PROMA
Sequence: MAQSFRIENDSMGTIKVPDQALWGAQTQRSLINFAIGHNKMPMKLIYSIVQIKASAAIVNCRLGVLDKQRKNFILNACNEISNGMHDEQFPLSVWQTGSGTQTNMNVNEVISNIASHLNGNKLGSHEPLHPNDHVNRSQSTNDVFPAAIQIATVQEILENLLPELDQLIETFDKKIIKWNRIIKTGRTHLQDAVPLTLGQEASAWKEQLIASRNRLNKSLNELYPLPLGGTAIGTGLNAPAKFDKEIALEIAKSTRSPFVSAQNKFAIMASHDALVHTMSQLKLLAVSLFKIVNDLRLLSCGPRGGLGELRLPENEPGSSIMPGKVNPTQCEAMAMVCTQIMALDSAVTMAGSGGHLQMNSYKPLIAFNLLESIDLLSSACKSSRILMIEGIEPNLEKIQNSLQNSLMLITSLTPIIGYEKASKIAQCAHEKDITLKEATKLLGYLNEDDFDRIVNPQSMTGMEN
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAIB_ECO5E
Sequence: MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKARETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMSKGKDPYYAGCGLYKCADGYIVMELVGITQIEECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLAAHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKGPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
What is the function of this protein?
Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine.  Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
What are the official names of this protein?
L-carnitine CoA-transferase, Crotonobetainyl-CoA:carnitine CoA-transferase.
What is the protein family that this protein belongs to?
Belongs to the CoA-transferase III family. CaiB subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS20_VEREI
Sequence: MASAKPKKKNPRLASGRKRVRQDIKINAANTSLRSKYRTAVKNVEKAVLAGDKTKATEQFAKMQAVVDTVADKGIFHKNKAARDKSRLSAKVKALALAA
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: EFG_ACIF5
Sequence: MARTTPIERYRNIGIMAHIDAGKTTTTERILFYTGVSHKIGEVHEGTAVMDWMAQEQERGITITSAATTCFWKGMDGQRAEHRINIIDTPGHVDFTIEVERSLRVLDGAMAVFCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRQGANFKRVVDQIATKLRGNPVPVQLPIGEEDHFSGVIDLMKMKSINWDDALQGTRFTEEDIPPALQADAEAARHFMVEAIADADEDVMMKYLEGEEISIAELQAALRKATISGAVVPVLCGSAFKNKGVQAALDAVLDYLPSPVDIKPVEGTNPDNGEEIVRFADDSEPFSALAFKIATDPFVGQLTFFRVYSGVLTAGSTVLNPGRNQKERIGRVLQMHANERHEIKEVLAGDIAAAVGLKTAYTGDTLCDLNKPIALEQMEFPEPVIHVAVEPKTKADQEKMGIALGKLAQEDPSFRVRTDQESGQTIISGMGELHLEIIVDRMKREFGVEATVGAPQVAYRETIRKTVESEGKFVRQSGGRGQYGHVWLRLEPLEPGSGFVFENGVVGGTVPKEFINPTEKGVEEALENGIIAGFPVVDVKVTIFDGSYHDVDSSEAAFKIAGSMGFKAGAAKANPVLLEPIFAVEVVTPEEYMGDIIGDINSRRGMMQGMEDEAGAKLIRCEVPLAEMFGYATTVRSLSQGRATYTMQFEKYMEVPGHVAEAIVKKSQR
What is the function of this protein?
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation.  During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively.  Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
What are the official names of this protein?
Elongation factor G, EF-G.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS17_ACIF5
Sequence: MTEAKNPRSLVGTVVSNLMDKSIVVNVERRIQHPLYKKYIRRSKKFHAHDAENICHIGDIVKIEECRPLSKTKSWRLVSVLAEGVIEGDNA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S17.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS17 family.
Protein: PDXJ_PROMM
Sequence: MASLGVNIDHIANVRQARQTVEPDPVPMALLAELGGADGITVHLREDRRHIQDRDLDLLRATVRSRLNLEMAATAEMVGIALKIQPDMVTLVPERRQEVTTEGGLDVAAQQGSLKGMVDQLQVAGIPVSLFVDPVSQQLEAAFKSGARWVELHTGAYAEACWADQSFELARLTEATARARSLGLRVNAGHGLTYQNVEAVAAIEGIEELNIGHTIVARSIAVGLKEAVREMKRLVQNPRREPLFG
What is the function of this protein?
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
What are the official names of this protein?
Pyridoxine 5'-phosphate synthase, PNP synthase.
What is the protein family that this protein belongs to?
Belongs to the PNP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MEND_LISIN
Sequence: MTNHEQVLTDYLAAFIEELVQAGVKEAIISPGSRSTPLALMMAEHPTLKIYVDVDERSAGFFALGLAKASKRPVVLLCTSGTAAANYFPAVVEANLSQIPLIVLTADRPHELRNVGAPQAMDQLHLYGSHVKDFTDMALPENSDEMLRYAKWHSSRAVDIAMKTPRGPVHLNFPLREPLVPILEPSPFTATGKKHHHVHIYYTHEVLDDSSIQKMVTECTGKKGVFVVGPIDKKELEQPMVDLAKKLGWPILADPLSGLRSYGAMDEVVIDQYDAFLKEADILDKLTPEVVIRFGSMPVSKPLKNWLEHLFGIRFYVVDPGAAWKDPIKAVTDMIHCDERFLLDIMQQNMPDDTKDASWLNRWTSYNQKAREIVLEEMANTTTLEEGKIVSELRRLLPDKAGLFIGNSMPIRDVDTYFSQIDKKIKMLANRGANGIDGVVSSALGASVVFQPMFLLIGDLSFYHDMNGLLMAKKYKMNLTIIIVNNDGGGIFSFLPQANEPKYFESLFGTSTELDFRFAAAFYDADYHEAKSVDSLEEAIDKASYHKGLDIIEVKTNRHENKANHQALWEKIATALKALD
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.
Protein: FEN1_DICDI
Sequence: MGIKKLTDLIEDNAPTSIKTNILKNYFGRIIAIDASTSLYQFLIAMNADVSSALTNQLGETTSHLQGMFYRTIKLISRGIKPIYVFDGSAPVLKSGELAKRQARRKEAKENLKEATEVGTNEEVQKFAKRVITVTRKQNEDCIKLLTLMGVPIVKAPCEAEAQCAEIVKKGKAWATGSEDMDSLTLGSTVLLRRLFFSEAKKMPILEFELQSVLEGLGLTQDEFIDLSILLGCDYCDSIKGIGPKRAIELIQKHKSLEEVIKHLDKSKYPLPEFFPYPEVRELFKNPNVIPADQLPPFQWKDPDVEGLNKFLVEEMGFSDVRVAQGIEKLKKFKNTSVQSRMDSFITVIKKPEDPNDKKKKVTKTPSKPSAKTSKKSSSTFKRK
What is the function of this protein?
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair.  During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.  It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation.  Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap.  Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions.  Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity.  Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
What are the official names of this protein?
Flap endonuclease 1, FEN-1, Flap structure-specific endonuclease 1.
What is the protein family that this protein belongs to?
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
What are the subcellular locations of this protein?
Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Protein: NRDR_XANCB
Sequence: MHCPFCQHNDTRVIDSRVSEDGTTIRRRRECEACGERFSTLETIELKLPTVVKSDGGREAFDARKLRTSFDRALQKRPVSEEQIEAAVRAVVHQLRMSGEREVGSLRVGEYVMVELRKLDHVGYVRFASVYRSFQDVADFREEIEKLERELPVGSEQLPLLEAALERAGKPGKR
What is the function of this protein?
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
What are the official names of this protein?
Transcriptional repressor NrdR.
What is the protein family that this protein belongs to?
Belongs to the NrdR family.
Protein: HEM11_FLAJ1
Sequence: MENNNVPKHLYFYSVGLSYKKADAEVRGQFSLDAVAKTRLLEQAKNDGIESLLVTSTCNRTEIYGFAEHPFQLIKLICDNSNGSVDAFQKVGFVYKNQEAINHMFRVGTGLDSQILGDFEIISQIKTSFTHSKSMGLANAFMERLVNAVIQASKRIKTETEISSGATSVSFASVQYILKNVEDISNKNILLFGTGKIGRNTCENLVKHTKNEHITLINRTKDKAEKLAGKLNLIVKDYSELHLELQKADVVVVATGAQNPTVDKAILNLKKPLLILDLSIPKNVNENVEELEGVTLIHMDYLSQLTDETLENRKLHIPAAEAIIEEIKEEFVTWMKGRKFAPTINALKEKLNAIKASELDFQSKKIADFNEEQAEIISNRIIQKITTHFANHLKDDDTMVDESIEWIEKVFKIKAS
What is the function of this protein?
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
What are the official names of this protein?
Glutamyl-tRNA reductase 1, GluTR 1.
What is the protein family that this protein belongs to?
Belongs to the glutamyl-tRNA reductase family.
Protein: VP2_AHSV4
Sequence: MASEFGILMTNEKFDPSLEKTICDVIVTKKGRVKHKEVDGVCGYEWDETNHRFGLCEVEHDMSISEFMYNEIRCEGAYPIFPRYIIDTLKYEKFIDRNDHQIRVDRDDNEMRKILIQPYAGEMYFSPECYPSVFLRREARSQKLDRIRNYIGKRVEFYEEESKRKAILDQNKMSKVEQWRDAVNERIVSIEPKRGECYDHGTDIIYQFIKKLRFGMMYPHYYVLHSDYCIVPNKGGTSIGSWHIRKRTEGDAKASAMYSGKGPLNDLRVKIERDDLSRETIIQIIEYGKKFNSSAGDKQGNISIEKLVEYCDFLTTFVHAKKKEEGEDDTARQEIRKAWVKGMPYMDFSKPMKITRGFNRNMLFFAALDSFRKRNGVDVDPNKGKWKEHIKEVTEKLKKAQTENGGQPCQVSIDGVNVLTNVDYGTVNHWIDWVTDIIMVVQTKRLVKEYAFKKLKSENLLAGMNSLVGVLRCYMYCLALAIYDFYEGTIDGFKKGSNASAIIETVAQMFPDFRRELVEKFGIDLRMKEITRELFVGKSMTSKFMEEGEYGYKFAYGWRRDGFAVMEDYGEILTEKVEDLYKGVLLGRKWEDEVDDPESYFYDDLYTNEPHRVFLSAGKDVDNNITLRSISQAETTYLSKRFVSYWYRISQVEVTKARNEVLDMNEKQKPYFEFEYDDFKPCSIGELGIHASTYIYQNLLVGRNRGEEILDSKELVWMDMSLLNFGAVRSHDRCWISSSVAIEVNLRHALIVRIFSRFDMMSERETFSTILEKVMEDVKKLRFFPTYRHYYLETLQRVFNDERRLEVDDFYMRLYDVQTREQALNTFTDFHRCVESELLLPTLKLNFLLWIVFEMENVEVNAAYKRHPLLISTAKGLRVIGVDIFNSQLSISMSGWIPYVERMCAESKVQTKLTADELKLKRWFISYYTTLKLDRRAEPRMSFKFEGLSTWIGSNCGGVRDYVIQMLPTRKPKPGALMVVYARDSRIEWIEAELSQWLQMEGSLGLILVHDSGIINKSVLRARTLKIYNRGSMDTLILISSGVYTFGNKFLLSKLLAKTE
What is the function of this protein?
The VP2 protein is one of the two proteins (with VP5) which constitute the virus particle outer capsid.  It is the major target of the host immunogenic response.
What are the official names of this protein?
Outer capsid protein VP2.
What is the protein family that this protein belongs to?
Belongs to the orbivirus VP2 family.
What are the subcellular locations of this protein?
Virion.
Protein: GSPM_ECOLI
Sequence: MIKSWWAEKSTSEKQIVAALAVLSLGVFCWLGVIKPIDTYIAEHQSHAQKIKKDIKWMQDQASTHGLLGHPALTQPIKNILLEEAKRENLAITLENGPDNTLTIHPVTAPLENVSRWLTTAQVTYGIVIEDLQFTLAGNEEITLRHLSFREQQ
What is the function of this protein?
Inner membrane component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.  Plays a role in the complex assembly and recruits GspL resulting in a stable complex in the inner membrane.  Provides thus a link between the energy-providing GspE protein in the cytoplasm and the rest of the T2SS machinery.
What are the official names of this protein?
Putative type II secretion system protein M, T2SS protein M, Putative general secretion pathway protein M, Transport protein PshM.
What is the protein family that this protein belongs to?
Belongs to the GSP M family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: DLRB1_HUMAN
Sequence: MAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNEIMVAPDKDYFLIVIQNPTE
What is the function of this protein?
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function.  Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
What are the official names of this protein?
Dynein light chain roadblock-type 1, Bithoraxoid-like protein, BLP, Dynein light chain 2A, cytoplasmic, Dynein-associated protein Km23, Roadblock domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the GAMAD family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton.
Protein: Y341_CARHZ
Sequence: MGEKIKNLPEELRPRERLLRHGPESLNPAELLAVLLGSGTPQENALELALRLLTTFGGLKGLIEVHPEQLKSFKGIGQAKAAKLLAALELARRYYELTGENKLNFLNPDDVYNYLRYKIGHKKQEQVVVLYLNTKNQLCGENIVAIGGVNHAGVSPGDIFREAVKIGAYAVIIAHNHPSGDPTPSKEDIDFTGRVKKASEILGIKLLDHIILGENKYISMKAERLF
What are the official names of this protein?
UPF0758 protein CHY_0341.
What is the protein family that this protein belongs to?
Belongs to the UPF0758 family.
Protein: RS13_SHEB2
Sequence: MARIAGINIPDQKHTVIALTAIFGIGRTRARAICAATAIAETAKIKELSEAQIDILREEVAKYIVEGDLRREISMNIKRLMDLGCYRGLRHRRSLPLRGQRTKTNARTRKGPRKPIRK
What is the function of this protein?
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA.  In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.  Contacts the tRNAs in the A and P-sites.
What are the official names of this protein?
30S ribosomal protein S13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS13 family.
Protein: MNMA_BARQU
Sequence: MFLNSLDLPGQPDNSRIVVAMSGGVDSSVVAGLLKKEGYDVIGITLQLYDHGAATHRVGACCAGQDIEDARRVAETLGIPHYVLDYEKRFREAVIDPFAESYAHGETPVPCVACNQTVKFADLLATARELGADALATGHYIRSRPHGAHRALFRPFDVERDQSYFLFATTQEQIDYLRFPLGDLPKAHVREIATEMGFVVADKHDSQDICFVPQGKYSDVITKLRPEAVNPGVIVHIDGQVLGKHSGIVNYTVGQRRGIGVATGEALYVVYLDVENARVIVGPREMLETHKLFLRDVNWLGDERLDNFPSDGLEMAVKVRSTRPSHLARLHYQEGVFSVDFLECENSVAPGQACVFYDGNGDGARILGGGFVTHSQRAVGVEMMLRRVLCNPETKAAVSSEFKTTASK
What is the function of this protein?
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
What are the official names of this protein?
tRNA-specific 2-thiouridylase MnmA.
What is the protein family that this protein belongs to?
Belongs to the MnmA/TRMU family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL35_LEPBL
Sequence: MPKLKTNRAAAKRFKFTKNNKIKRKSMNTRHILTKKGPKRRRRLRGLTLVNNSDWKSIVRLMPYGVR
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: CK5P1_CAEEL
Sequence: MLRQWWLRSVGSCSTVYRAHSGCSTSAAVKPKRAIPTDGLQLSDFIKESTKKQRQKAIIPSIEDTKEYLNPEDLQGNGRTVCYVTYGCQMNVSDMEIVRSIMTKYGFVESDKKENADIVLLMTCSIRDGAEKKVWNQLKLIRSNSVNKGQIVGVLGCMAERVRHDLLEKRNLVNIVAGPDSYRDLPRLVAVAAGGSNGINVQLSLDETYADVQPIRVDSASKTAFISIMRGCDNMCTYCVVPFTRGRERSRPIESIVEEVQRLRDQGYKQVTLLGQNVNSYRDMTSMDFSMAPSTSQEDRVPGFKTVYKPKSGGLTFTTLLEKVADAAPDIRFRFTSPHPKDFPMQLIELIASRPNLCKQLHLPAQSGDDETLERMERGYTRDLYLRLVDDIRHVLPSVSLTSDFIAGFCGETEQAHQNTLSLIRAVRYSFCFVFPYSMRGKTRAHHRLTDDVPEDVKARRHLDLTTVFREEALKLNQALIGSEQTVLLEGKSKRDASFSHGRIDGGVKAVFDNSKLCLEPGQYAKILITDANSQTLKAQLIGQSSI
What is the function of this protein?
Potential regulator of CDK5 activity.
What are the official names of this protein?
CDK5RAP1-like protein.
What is the protein family that this protein belongs to?
Belongs to the methylthiotransferase family. MiaB subfamily.
Protein: MUTS2_LISW6
Sequence: MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATNFQVVQKSQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEIGGDLNGLEIYQIGSNLRVSRQMKNFMTDLLEMGVELPLLGALSDELLVLKEVEEDIAISVDESGKILDTASEALSTIRRTLRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKALQAKEKQEIERILAEISASLAGWINEIHHNTFILGRYDFIFAKARFGKAMKAVTPHLSDAGIVHLIAARHPLLDAANVVANDIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIVSILEKVNHKSLILYDELGAGTDPQEGAALAIAILDASHEKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYKLLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGADALLKDLQKEITNYYQQKDKLMEQAREKAANIVTKAEVEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGKAKPKTINKTIPQAPKQKPHVFQVGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTTDLEYIQPETPKKQRIITSVHSSDSPVKSELDLRGERYEDALQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK
What is the function of this protein?
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
What are the official names of this protein?
Endonuclease MutS2.
What is the protein family that this protein belongs to?
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Protein: HTPX_PELTS
Sequence: MNNLKVWLLMAALSAILVLIGGAIGGKSGALLFFLISLGMNLFSYYYSDKVAISMTRSRPVSEEEAPGLYDVVRRLTKRAGLPMPRLYITPSPQPNAFATGRNPAHSAVAVTEGLLRLLNQSELEGVLAHELAHIKNRDVLIGTIAAAFAGAITMISNIVQWGAFFGMGQDDEEGGGGSFIASLLLALIAPVAAMIIQLAISRSREYLADETGARMAGNSGGLANALLKLDSAARRIPMQVNPAASHLFIVNPLSGESIARLFSTHPPISERVKRLNAMAI
What are the official names of this protein?
Protease HtpX homolog.
What is the protein family that this protein belongs to?
Belongs to the peptidase M48B family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.