PharMolix/UniProtQA huggingface dataset:
Protein: PYRH_ALIB4
Sequence: MNKRVLVKFSGEALAGAEGYGIDTKILDYIAEEIKSLVENGIEVAIVIGGGNIIRGVTAAADGVIKRTSADYMGMLGTVINGVAMQEALEYKGLSARLQTAIKMEQIAEPFIVRKAMRHFEKGRVVIFGAGTGNPYFTTDTGATLRATEIGASMLIKATKVNGVYDKDPMKYPDAQKLETLSYDRALEDQIKVMDDTAIALAKDNKLPIAVTNMNEKGNLLRIVKGDYSKCSIVK
What is the function of this protein?
Catalyzes the reversible phosphorylation of UMP to UDP.
What are the official names of this protein?
Uridylate kinase, UK, Uridine monophosphate kinase, UMP kinase, UMPK.
What is the protein family that this protein belongs to?
Belongs to the UMP kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: KDPB_ERWT9
Sequence: MSRNQLALFDAALMRVALLDALKKLDPRTQVRNPVMFVVWLGSVVTTLLAVAMAAGKTPGDTGFTVAISVWLWFTVLFANFAEALAEGRSKAQANSLKGVTKTSFAKKLNEAKYGTSHYPVAADTLRKGDWVLVEAGDIIPCDGEVLEGGASVDESAITGESAPVIRESGGDFSSVTGGTRILSDWLVVQCSVNPGETFLDRMIAMVEGATRRKTPNEIALTILLLALTIVLLLATVTLWPFSAWGGNPVSITVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGDVDVLLLDKTGTITLGNRQATQFLPAAGVSEEQLADAAQLASLADETPEGRSIVVLAKQKFNLRERDLNSMGATFIPFSAQTRMSGVNVQQRAIRKGAADAVRRYIDSNGGQFPGEVNSLVDRVARAGGTPLVVSDGNRVMGVVALKDIVKGGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGVDDFLSEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLLEVVHIGKQMLMTRGSLTTFSIANDVAKYFAILPAAFAATYPQLNQLNVMGLHSPASAILSAVIFNALVIVFLIPLALKGVSYRALSAAALLRRNLWIYGVGGLLVPFLGIKLIDMLLTVTGLA
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
What are the official names of this protein?
Potassium-transporting ATPase ATP-binding subunit, ATP phosphohydrolase [potassium-transporting] B chain, Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: HIS7_THET8
Sequence: MREATVERATAETWVWLRLGLDGPTGGKVDTGLPFLDHMLLQLQRHGRFLLEVEARGDLEVDVHHLVEDVGIALGMALKEALGDGVGLERYAEAFAPMDETLVLCVLDLSGRPHLEFRPEAWPVVGEAGGVNHYHLREFLRGLVNHGRLTLHLRLLSGREAHHVVEASFKALARALHKATRRTGEGVPSTKGVL
What are the official names of this protein?
Imidazoleglycerol-phosphate dehydratase, IGPD.
What is the protein family that this protein belongs to?
Belongs to the imidazoleglycerol-phosphate dehydratase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: XPO4_CHICK
Sequence: MMAAAAAAGGAPEVIAQLENAAKVLMAPPSMVNNEQRQHAEHIFLSFRKSKSPFAVCKHILETSKVDYVLFQAATAIMEAVVREWILLEKTSIESLRTFLLTYVLQRPNLQKYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSSSSKTSNIGLSMEFHGNCKRIFQEDDLRQIFMLTVEVLQEFRRRENLNAQMSSVFQRYLALANQVLSWNFLPPNLGRHYIAMFESSQNVMLKPTESWRETLLDSRVMELFFTVHRKIREDTDMAQDSLQCLAQLASLHGSVFPDEGSQVDYLAHFIEGLLNTISGIEIEDSEAVGISSIISNLITVFPRNILTAIPNELFSSFVNCLAHLTCSFGRSAALEEVLDKDDMVYMEAYDKLLESWLTLVQDDKHFHKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDRDQFCDQLASVGMLGRIAAEHCIPLLTSLLEDRVTRLHGQLQRHQQQLLASPASGSIDNKVLDDLYEDIHWLILVTGYLLANDTQGETPLIPPEVMEYSIKHSTEVDINTTLQILGSPGEKASSIPGYNRTDSVIRLLSAILRVSEVESRAIRANLTHLLSPQMGKDIVWFLKRWAKTYLLADEKLYDQISLPFSTAFGADTEGSQWIVGYLLEKVISNLAVWSSEQDLANDTVQLLVTLVERRERANLVIQCENWWNLAKQFARRSPPLHYLSSSVQRTLMKALVLGGFAHMDTEMKQQYWTEVLQPLQQRFLNVINQENFQQICQEEEVKQEITATLEALCGIAEATQIDNVAILFNFLMDFLNNCIGLMEVYKNTPETVNLIIEVFVEVAHKQICYLGEAKAMNLYEACLTLLQVYSKNNLGRQRIDVTAEEDQYQDLLLIMELLTNLLSKEFIDFSDTDEVFRGHEPGQATNRTVSAADVVLYGVNLVLPLMSQDLLKFPSLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMSSMSSEVCQLCLEAVTPLAEQCAKAQETDSALFLATRHFLKMVFDMLVLQKHNTEMTTAAGEAFYTLVCLHQAEYSELVETLLSTQQDPVIYQRLADAFNKLTASSTPPTLDRKQKMAFLKSLEEFMANVGGLLCVK
What is the function of this protein?
Mediates the nuclear export of proteins (cargos) with broad substrate specificity.
What are the official names of this protein?
Exportin-4.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: ECFA2_STAAS
Sequence: MTIRFDNVSYTYQKGTPYQHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQFPESQLFEDTVEREMIFGPKNFKMNLDEAKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVVDEPTAGLDPQSKRQVMRLLKSLQTDENKAIILISHDMNEVARYADEVIVMKEGSIVSQTSPKELFKDKKKLADWHIGLPEIVQLQYDFEQKYQTKLKDIALTEEAFVSLYKEWQHEK
What is the function of this protein?
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.  Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
What are the official names of this protein?
Energy-coupling factor transporter ATP-binding protein EcfA2, ECF transporter A component EcfA2.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL5_DELAS
Sequence: MARLQKLYREKIAAELKEKFGYTSSMEVPRLTKITLNMGVSEAVADKKVMDNAVADLTKIAGQKPVVTKAKKAIAGFKIREGQAIGCMVTLRGVQMYEFLDRFVTVALPRVRDFRGISGRSFDGRGNYNVGVKEQIIFPEIEYDKVDALRGLNISITTTARTDDECKALLAAFRFPFKN
What is the function of this protein?
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.  In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement.  Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
What are the official names of this protein?
50S ribosomal protein L5.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL5 family.
Protein: CAPSD_WHV4
Sequence: MDIDPYKEFGSSYQLLNFLPLDFFPDLNALVDTATALYEEELTGREHCSPHHTAIRQALVCWDELTKLIAWMSSNITSEQVRTIIVNHVNDTWGLKVRQSLWFHLSCLTFGQHTVQEFLVSFGVWIRTPAPYRPPNAPILSTLPEHTVIRRRGGARASRSPRRRTPSPRRRRSQSPRRRRSQSPSANC
What is the function of this protein?
Self assembles to form an icosahedral capsid.  Most capsids appear to be large particles with an icosahedral symmetry of T=4 and consist of 240 copies of capsid protein, though a fraction forms smaller T=3 particles consisting of 180 capsid proteins.  Entering capsids are transported along microtubules to the nucleus.  Phosphorylation of the capsid is thought to induce exposure of nuclear localization signal in the C-terminal portion of the capsid protein that allows binding to the nuclear pore complex via the importin (karyopherin-) alpha and beta.  Capsids are imported in intact form through the nuclear pore into the nuclear basket, where it probably binds NUP153.  Only capsids that contain the mature viral genome can release the viral DNA and capsid protein into the nucleoplasm.  Immature capsids get stuck in the basket.  Capsids encapsulate the pre-genomic RNA and the P protein.  Pre-genomic RNA is reverse-transcribed into DNA while the capsid is still in the cytoplasm.  The capsid can then either be directed to the nucleus, providing more genomes for transcription, or bud through the endoplasmic reticulum to provide new virions.
What are the official names of this protein?
Capsid protein, Core antigen, Core protein, HBcAg, p21.5.
What is the protein family that this protein belongs to?
Belongs to the orthohepadnavirus core antigen family.
What are the subcellular locations of this protein?
Virion. Host cytoplasm.
Protein: ATPF_ALKPO
Sequence: MGFDINWGSALYQLLAFSVLLFFLSKFALKPLLGIMEKREQMINEQISSAEKNRKDSEAFIAEQRQALEQARMEANEIIQNAKKLSEQQGQDIVKAARNDAERIKESAVAEIQREKEQAVSALREQVAGLSVLIATKVIEKELNEAEQEKLVQEYLKEVGEEL
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass membrane protein.
Protein: PCKG_PARP8
Sequence: MNHPAFAAHSTLEAPAWVKHKKLIEWVQRVAALAKPERIVWCDGSQEEYDRLTAQMVAAGTLRRLNPAKRPNSYLACSDPSDVARVEDRTFICSQRREDAGPTNNWIAPAEMRATLDGLFDGAMRGRTMYVVPFSMGPLGSPIAHIGVELSDSPYVVSNMRIMTRMGRKVYDVLGEDGEFVPCVHSVGAPLAAGQKDVAWPCNDTKYIVHFPESREIWSYGSGYGGNALLGKKCFALRIASTMGRAEGWLAEHMLVLGVTSPEGKKHHVAAAFPSACGKTNFAMLIPPQGMNGWKITTIGDDIAWIKPGKDGRLYAINPEAGYFGVAPGTSEKTNFNAMATLKENVIFTNVALTDDGDVWWEGMTDEPPAHLIDWQGRDWTPAIAKETGRKAAHPNARFTAPASQCPSIDADWENPAGVPIDAFVFGGRRSTTVPLVTEARDWVEGVYMAATMGSETTAAAAGQQGVVRRDPFAMLPFCGYNMSDYFAHWLKTGVKLEQMSVRTPKIFCVNWFRKGDDGKFVWPGFGENMRVLRWMVDRIEGKAKGEEHAFGVSPRYDDLDWSGLDFTREQFEQVISVDDAAWRKELALHSELFDTLKQGLPVALQDTRSALEKKLTA
What is the function of this protein?
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase [GTP], PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS10_STRS2
Sequence: MANKKIRIRLKAYEHRTLDTAAAKIVETATRTGAQVAGPVPLPTERSFYTIIRATHKYKDSREQFEMRTHKRLIDIINPTQKTVDALMKLDLPSGVNVEIKL
What is the function of this protein?
Involved in the binding of tRNA to the ribosomes.
What are the official names of this protein?
30S ribosomal protein S10.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS10 family.
Protein: RS20_GEOSW
Sequence: MANIKSAIKRAKTSEKRRAHNASMRSAMRTAIKKFEAFVELKDVEKAQEAFIIASKKLDKAVTKGLIHKNTASRKKSRLAKKLNSIIAS
What is the function of this protein?
Binds directly to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S20.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS20 family.
Protein: MLTF_SHIFL
Sequence: MKKLKINYLFIGILALLLAVALWPSIPWFGKADNRIAAIQARGELRVSTIHTPLTYNEINGKPFGLDYELAKQFADYLGVKLKVTVRQNISQLFDDLDNGNADLLAAGLVYNSERVKNYQPGPTYYSVSQQLVYKVGQYRPRTLGNLTAEQLTVAPGHVVVNDLQTLKETKFPELSWKVDDKKGSAELMEDVIEGKLDYTIADSVAISLFQRVHPELAVALDITDEQPVTWFSPLDGDNTLSAALLDFFNEMNEDGTLARIEEKYLGHGDDFDYVDTRTFLRAVDAVLPQLKPLFEKYAEEIDWRLLAAIAYQESHWDAQATSPTGVRGMMMLTKNTAQSLGITDRTDAEQSISGGVRYLQDMMSKVPESVPENERIWFALAAYNMGYAHMLDARALTAKTKGNPDSWADVKQRLPLLSQKPYYSKLTYGYARGHEAYAYVENIRKYQISLVGYLQEKEKQATEAAMQLAQDYPAVSPTELGKEKFPFLSFLSQSSSNYLTHSPSLLFSRKGSEEKQN
What is the function of this protein?
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product.  Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus.  Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
What are the official names of this protein?
Membrane-bound lytic murein transglycosylase F, Murein lyase F.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the transglycosylase Slt family.
What are the subcellular locations of this protein?
Cell outer membrane; Peripheral membrane protein. Note=Attached to the inner leaflet of the outer membrane.
Protein: UBC_ASFK5
Sequence: MVSRFLLTEYRNLTENPSEHFKVSVNENNLTEWDVILKGPSDTFYEGGLFKAKITFPPNYPYEPPKLTFTSEMWHPNIYPDGRLCISILHTDNVEERGMTWSPAQKIETVLLSVISLFNEPNTDSPANVDAAKSYRKLMHKEDLESYPMEVKKTVKKSLDECSAEDIEYFKNAVFNVPAIPSDAYEDEHEDEEMEDGTYILTYDDEDEEEEDDEMDDE
What is the function of this protein?
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity).  Performs the second step in the ubiquitination reaction that targets specifically a protein for degradation via the proteasome (By similarity).  By controlling the ubiquitination status of specific host proteins, the virus may target them to degradation and thereby optimize the viral replication (By similarity).  May be implicated in the shutoff of protein synthesis through its interactions with components of the host translation machinery (By similarity).  Blocks p65 nuclear translocation upon cytokine stimulation, thereby impairing NF-kappa-B signaling (By similarity).  Inhibits type I IFN production and 'Lys-63'-linked polyubiquitination of host TBK1 through binding to host RNF138.  This binding enhances the interaction between RNF138 and RNF128 and promotes RNF138-mediated degradation of RNF128.  Also inhibits the activation of AP-1 transcription factor (By similarity).  Monoubiquitinates the viral protein P15/PIG1 in vitro (By similarity).
What are the official names of this protein?
Ubiquitin-conjugating enzyme E2, E2 ubiquitin-conjugating enzyme, UBCv1, Ubiquitin carrier protein, Ubiquitin-protein ligase, pI215L.
What is the protein family that this protein belongs to?
Belongs to the ubiquitin-conjugating enzyme family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus. Note=Accumulates in cytoplasmic viral factories. Faintly detected in the nucleus.
Protein: MAB21_DROME
Sequence: MLVPSDMIAAQSKMVYQMNKYCADRVQVRKAQIHKQIQEVCRIVQDVLKEVEVQEPRFISSLNDYNGRFQGLEVISPTEFEIIIYLNQMGVLNFVDDGTLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQACDKCAYRDIVKMIADTTEVKLRIRERIIVQITPAFKCAGLWPRSASHWPLPGIPWPHPNIVAEVKTEGFNMLSKECIALQGKNSAMEGDAWVLSFTDAENRLLQGASRRRCLSILKTLRDRHLDLPGNPVTSYHLKTLLLYECEKHPREMEWEENCIADRINGIFLQLISCLQCRRCPHYFLPNMDLFKGKSPGALENAAKQVWRLTRIMLTNVRCLEEL
What are the official names of this protein?
Protein mab-21.
What is the protein family that this protein belongs to?
Belongs to the mab-21 family.
Protein: CAPP_VEREI
Sequence: MQPADKDLPLMDDIRLLGRILGDVIREQEGPRVYALVEQVRKLSVSFRRDADQEADRALKKLLESLSTGQTVGVIRAFTYFSHLANLAEDRHRIRRRAVHERAGDTQEGSIELALARLRAAGIAPQTIAQTLAGSHVAPVLTAHPTEVQRKSILDAERSIAQLLAERDDIQARARLYDGANDALTPRALAANEALLRARVTQLWQTRLLRYSKLTVADEIENALSYYEATFLREIPEIYAALENALGQHPVHSFLRMGQWIGGDRDGNPNATAQTLQYALGRQAEVALRHYLTEVHYLGGELSLSTRLVQVSAPMQALALRSPDRNEHRQDEPYRLALTGIYARLAATLKALTGGEAARHAVAPQNAYASAQEFLADLRVIEDSLTAHHGAALAAGRLHPLIRAVQVFGFHLATVDLRQSSDKHELVVAELLATARVQERYADLPEAGKRALLIRLLNDARPLRVVGARYSAHAQGELAIFETARALRERFGAEAIRHYIISHTETMSDLLEVLLLHKEVGLMSGTLDDAAARNQLIVVPLFETIADLRNAAPIMREFYALPGVAALVQRSGGEQDIMLGYSDSNKDGGIFTSNWELYRAEIALVQLFDELAASHGIQLRMFHGRGGTVGRGGGPSYQAILAQPPGTVRGQIRLTEQGEVIASKYANPEIGRRNLEILVAATLEATLLQPTKPAPKTFLAAAGQLSQASMAAYRALVYETPGFTEYFFNATPIREIAELNIGSRPAARKASQKIEDLRAIPWGFSWGQCRLTLPGWYGFGAAVAAFVNLQGKTPGAQLALLQRMYRQWPFFRTLLSNMDMVLAKSDLALAGRYSELVSDARLRKKVFAAIEAEWHSTADALSRITGDQQRLAHNSALARSIKHRFAYIDPLHHLQVELVRRWRAGQDDERVQTGIHISINGIAAGLRNTG
What is the function of this protein?
Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
What are the official names of this protein?
Phosphoenolpyruvate carboxylase, PEPC, PEPCase.
What is the protein family that this protein belongs to?
Belongs to the PEPCase type 1 family.
Protein: HR3_MANSE
Sequence: MNNNQFHELFGSQWPPDQHGGHSSASTMLHQQTMPQTMQLKREPHTEVGVMHNQMGMDITSGSVADSTSPPPGSSEGMFGPISGMFMDKKAANSIRAQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSTVVNYQCPRNKACVVDRVNRNRCQYCRLQKCLKLGMSRDAVKFGRMSKKQREKVEDEVRYHKAQMRAQNDAAPDSVYDAQQQTPSSSDQFHGHYNGYPGYASPLSSYGYNNAGPPLTSNMSSIQAQPQAQQPYDYADSTTTYEPKQPGYLDADFIGQVEGDISKVLVKSLAERHANTNPKLEYINEMFSKPQDVSKLLFYNSMTYEEMWLDCADKLTAMIQNIIEFAKLIPGFMKLTQDDQILLLKSGSFELAIVRLSRLIDVNREQVLYGDVVLPIRECVHARDPRDMALVSGIFEAAKSIARLKLTESELALYQSLVLLWPERHGVMGNTEIRCLFNMSMSAMRHEIEANHAPLKGDVTVLDTLLAKIPTFRELSLMHLGALSRFKMTHPHHVFPALYKELFSLDSVLDYTHG
What is the function of this protein?
Putative receptor whose ligand is not yet known.
What are the official names of this protein?
Probable nuclear hormone receptor HR3, mHR3, Nuclear receptor subfamily 1 group F member 4.
What is the protein family that this protein belongs to?
Belongs to the nuclear hormone receptor family. NR1 subfamily.
What are the subcellular locations of this protein?
Nucleus.
Protein: STON1_MOUSE
Sequence: MYSTNPGSWVTFDDDPAFQSSQKRKDFSLETQGVCRPNGLKLTLPTLRDPPSTPSSASSTPLSSPMVDFYFSPGPPSNSPLSTPTKDFPGFPGIPKAGTHVLYPIPECSSSSAPTTAGGVGPPLLLTKPDCSPHVSLPSSHSHTQPTPTLGFTEDAGPQRVQSEARQFEYFQDHCAFSNPFWKDEGSASPFPLDSLASRKPFSPKDKEVPIGHKSLTQCSLDYICEKLEHLHSAETQDPLGDLSMQDPYAGDTVSFVPHSLFRSQPRAGWSFMLRIPEKKNMMSSRQWGPIFLKVLPGGILQMYYEKGLEKPFKEFQLDPHCRLSEPKLENFSMAGKIHTVKVEHVSYSEKRKYHAKTEVVHEPEVEQMLKLGSTEHRDFLEFLTTVEEELIKLPATAKPKNKSYEEQEICLDIQDSLWGKVTKEGQLVESAVVTQICCLCFLNGPAECFLALNDRELQKRDECYFEKEPEKKGIAILDYHFHTCVKAEEFEQSRIIKFVPLDACRFELMRFKTSYEAGELPFAVKSVVTVQGAYVELQAFVNMTPAAQGSPHAGALRSCNNIMIHFPVPAQWIKALWTRNLQRQKSLKAKMNRRACLGSLQEPESEPVIQVTVGSAKYESAYRAVVWKIDRLPDKNSSPDQPHCLSYKLELGSDQEVPSDWYPFATVQFSMLEACASRTEVRSLGVESDAQPQKHVCQRACYNIQVEIEKKWIQVDGEDADKTGGCVTQ
What is the function of this protein?
May be involved in the endocytic machinery.
What are the official names of this protein?
Stonin-1, Stoned B-like factor.
What is the protein family that this protein belongs to?
Belongs to the Stoned B family.
What are the subcellular locations of this protein?
Cytoplasm. Membrane. Note=Some fraction is membrane-associated.
Protein: GLYA_PROM0
Sequence: MNILQNLKESDPVISNFIKSEKNRQETHLELIASENFASIAVMEAQGSVLTNKYAEGLPQKRYYGGCEFVDQIEELAIQRAKKLFNANWANVQPHSGAQANAAVFLSLLKPGDTIMGMDLSHGGHLTHGSPVNMSGKWFNAVHYGVNKETSELNFDEIREIALETKPKLIICGYSAYPRTIDFESFRNIADEVGAFLMADIAHIAGLVASKLHPNPIPYCDVVTTTTHKTLRGPRGGLILCKDAEFGKKFDKSVFPGTQGGPLEHIIAAKAVAFGEALQPDFVNYSQQVIKNAKVLASTLINRGIDIVSGGTDNHIVLLDLRSINMTGKIADLLVSEVNITANKNTVPFDPESPFVTSGLRLGTAALTTRGFNENAFAEVGEIIADRLLNPDDSLIESQCKERVLTLCNRFPLYESKLEASIK
What is the function of this protein?
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier.  This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules.  Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
What are the official names of this protein?
Serine hydroxymethyltransferase, SHMT, Serine methylase.
What is the protein family that this protein belongs to?
Belongs to the SHMT family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LEU3_CORA7
Sequence: MKLAVIGGDGIGPEVTAEALKVLRAVRQDVEVTDYDLGARRYLRNGELLSDADFASLREHDAILLGAIGAPGEVPPGVLERGLLLKMRFALDHHVNLRPSKLYPTSTSPLANPGDIDFVVVREGTEGLYCGNGGTLREGTEHEVASEVSQNTRFGVERVVRDAFQRAMGRRKHVTLVHKTNVLVNAGGLWQRTVNEVAQEFPEVTVDYNHIDAATIYMVTDPARYDVIVTDNLFGDILTDLAGAVTGGIGLAASGNIDASGANPSMFEPVHGSAPDIAGKGIADPTAAILSAAMLLRHLGDEENAVRIEEAVAADVSARGDAQARTTEIGDRIAAALSA
What is the function of this protein?
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate.  The product decarboxylates to 4-methyl-2 oxopentanoate.
What are the official names of this protein?
3-isopropylmalate dehydrogenase, 3-IPM-DH, Beta-IPM dehydrogenase, IMDH.
What is the protein family that this protein belongs to?
Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DXS_THET8
Sequence: MILDKVNSPEDLKRLSLEELLLLAEEIRSEIIRVTAQNGGHLASSLGAVELVLALHRVFDSPRDRILFDVGHQAYAHKLVTGRKDRFHTLRKEGGISGFTKVSESPHDAITAGHASTSLANALGMVLARDLMGEDYHVVAVIGDGALTGGMALAALNKIGELQKRMLIVLNDNEMSISENVGALNKYFKELQIRKWVQDAEKLGKNILERISPQLFGLVDRAKEAAKFLLHQENPFYAWGIRYVGPVDGHDLKGLVHILEHLKALDGPTLLHVVTKKGKGYKVAEADPIYWHGPPGFDPKKPEKVSKGYTWSQAFGDAVTELAHMEPRLFVLTPAMREGSGLVRYSLEHPERYLDVGICEDVAVTTAAGLALRGMKPIVAIYSTFLQRAYDQVIHDVAIENLPVVFAIDRAGIVGADGATHHGVFDIAYLRTVPNLQIAAPKDALELRAMLKKALEVGGPVAIRYPRDNVERAPEGVWPEIAWGKWEVLKEGTEAYILAFGKTLRYALEAAGDDPRVGVVNARFLKPLDREMLRELSRYKLLTVEDHQKMGGFGSAVLEALNEMGLKPEVQILGLPDRFFEHGAIPSLHRQAGIDAEGIRKALAAMGVALVHERA
What is the function of this protein?
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
What are the official names of this protein?
1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS.
What is the protein family that this protein belongs to?
Belongs to the transketolase family. DXPS subfamily.
Protein: DNAJ_STAA8
Sequence: MAKRDYYEVLGISKDASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDDNKRASYDQFGHDGPQGFGGQGFNGSDFGGFSGFGGGGFEDIFSSFFGGGRQRDPNAPQKGDDLQYTMTLTFEEAVFGTTKEISIRKDVTCETCHGDGAKPGTSKKTCSYCNGAGHVAVEQNTILGRVRTEQVCPKCNGSGQEFEEACPTCHGKGTENKTVKLEVKVPEGVDNEQQIRLAGEGSPGVNGGPAGDLYVVFRVKPSETFKRDGDDIYYKLNVSFPQAALGDEIKIPTLNNEVMLTIPAGTQTGKQFRLKEKGIKNVHGYGYGDLYVDIKVVTPTKLTDRQKELMKEFAQLNGEEINEQPSNFKDRAKRFFKGE
What is the function of this protein?
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion.  Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex.  GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.  Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
What are the official names of this protein?
Chaperone protein DnaJ.
What is the protein family that this protein belongs to?
Belongs to the DnaJ family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NEF_HV2BE
Sequence: MGASGSKKLSKHSRGLRERLLRARGDGYGKQRDASGGEYSQFQEESGREQNSPSCEGQQYQQGEYMNSPWRNPATERQKDLYRQQNMDDVDSDDDDLIGVPVTPRVPRREMTYKLAIDMSHFIKEKGGLQGMFYSRRRHRILDIYLEKEEGIIPDWQNYTHGPGVRYPMYFGWLWKLVSVELSQEAEEDEANCLVHPAQTSRHDDEHGETLVWQFDSMLAYNYKAFTLYPEEFGHKSGLPEKEWKAKLKARGIPYSE
What is the function of this protein?
Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
What are the official names of this protein?
Protein Nef, 3'ORF, Negative factor, F-protein.
What is the protein family that this protein belongs to?
Belongs to the lentivirus primate group Nef protein family.
What are the subcellular locations of this protein?
Host cell membrane; Lipid-anchor; Cytoplasmic side. Note=Associates with the inner plasma membrane through its N-terminal domain.
Protein: CTSL2_DICDI
Sequence: MSSGLKTQTTIDILHDHSVESSSDHLYILKQQQQHQHEDTDSPKKKKLRHQCEETSQYIVPSLNDEVDDLGHHHLHHHHVNNINNSLLKQGLSALSSLSASSTSSISPSSSQSSSPLKQSERSIATSIDSMNDSTSSSSSSNNNNNFSSVPSHNIYTPSCLLSNLNNDTDSIIPNMNGSTDGDGGDIRREKVDENDEEVLCNDNHLSKDNEQEDNMVSFLNESNEEVIQTNNNNNNDNNNSSNICINNFCNINNNQQQQQQQQQQQQNNVNSSIILEDSNKENKTESNNSNSNSNSSPSFFHNLQQHPTSAATTTTTTTTTITTTSATTSIIIKEDNSDDEIDDECDDESEEEEEDEEEFNPFLFIKQLANATTMPPPVALPPKEHSSPKISLVLDLDETLVHCSTEPLEQPHLTFPVFFNNTEYQVFAKKRPFFEEFLHKVSDIFEVIIFTASQEVYANKLLNMIDPNNKIKYRLYRDSCVYVDGNYLKDLSVLGRDLKQVVIIDNSPQSFGFQVDNGIPIESWFEDENDKELLQLVPFLESLTNVEDVRPHIRDKFKLYQLISQA
What is the function of this protein?
Probable phosphatase.
What are the official names of this protein?
CTD small phosphatase-like protein 2, CTDSP-like 2.
What is the protein family that this protein belongs to?
Belongs to the CTDSPL2 family.