PharMolix/UniProtQA huggingface dataset:
Protein: M1_I89A2
Sequence: MSLLTEVETYVLSIVPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLYRKLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFGLVCATCEQIADSQHRSHRQMVATTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEIASQARQMVQAMRAIGTHPSSSTGLKDDLLENLQTYQKRMGVQMQRFK
What is the function of this protein?
Determines the virion's shape: spherical or filamentous.  Clinical isolates of influenza are characterized by the presence of significant proportion of filamentous virions, whereas after multiple passage on eggs or cell culture, virions have only spherical morphology.  Filamentous virions are thought to be important to infect neighboring cells, and spherical virions more suited to spread through aerosol between hosts organisms.
What are the official names of this protein?
Matrix protein 1, M1.
What is the protein family that this protein belongs to?
Belongs to the influenza viruses Matrix protein M1 family.
What are the subcellular locations of this protein?
Virion membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus.
Protein: RRP42_SULIK
Sequence: MSSTPSNQNIIPLIKKESIVSLFEKGTRQDGRKLTDYRPLSITLDYAKKADGSALVKLGTTMVLAGTKLEIDKPYEDTPNQGNLIVNVELLPLAYETFEPGPPDENAIELARVVDRSLRDSKALDLTKLVIEPGKSVWTVWLDVYVLDYGGNVLDACTLASVAALYNTKVYKVEQDSNGFRVNKNEVVGKLPLNHPVVTVSIAKVDKYLIVDPDLDEESIMDTKVSFSYTPDLKIVGIQKSGKGSMSLQDIDQAENTARLVAVKLLEELKKQLGI
What is the function of this protein?
Non-catalytic component of the exosome, which is a complex involved in RNA degradation.  Contributes to the structuring of the Rrp41 active site.
What are the official names of this protein?
Exosome complex component Rrp42.
What is the protein family that this protein belongs to?
Belongs to the RNase PH family. Rrp42 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AC75_NPVAC
Sequence: MSNLMKNFFTELVKSTTFTTKVSVVKTTLSNWLCEQVYPDKDFSLKLKRVVNMFLNNEIENNKIYKLVETVDSSNKLSRRQVDFLIHALLNNVSVTFTLHRFVDDNVLTQDELSFLANFLVTKMDEAYQLPAY
What is the function of this protein?
Plays a role in nuclear egress of nucleocapsids and intranuclear microvesicle formation.
What are the official names of this protein?
Protein Ac75.
What are the subcellular locations of this protein?
Virion. Host cytoplasm. Host nucleus. Note=Localizes predominantly in the host intranuclear rim, site of several morphogenetic processes associated with occlusion-derived virions (ODV).
Protein: RR15_SECCE
Sequence: MKKKGGRKIFGFMVKEEKEENRGSVEFQVFSFTNKIRRLASHLELHKKDFSSERGLRRLLGKRRRLLAYLAKKNRVRYKKLIGQLNIREQ
What are the official names of this protein?
30S ribosomal protein S15, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS15 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FEPB_ECOLI
Sequence: MRLAPLYRNALLLTGLLLSGIAAVQAADWPRQITDSRGTHTLESQPQRIVSTSVTLTGSLLAIDAPVIASGATTPNNRVADDQGFLRQWSKVAKERKLQRLYIGEPSAEAVAAQMPDLILISATGGDSALALYDQLSTIAPTLIINYDDKSWQSLLTQLGEITGHEKQAAERIAQFDKQLAAAKEQIKLPPQPVTAIVYTAAAHSANLWTPESAQGQMLEQLGFTLAKLPAGLNASQSQGKRHDIIQLGGENLAAGLNGESLFLFAGDQKDADAIYANPLLAHLPAVQNKQVYALGTETFRLDYYSAMQVLDRLKALF
What is the function of this protein?
Part of the ABC transporter complex FepBDGC involved in ferric enterobactin uptake (PubMed:3011753).  Binds ferric enterobactin (PubMed:7551033, PubMed:10986237, PubMed:25173704).  Can also bind ferric enantioenterobactin, the left-handed stereoisomer of the natural E. coli siderophore, and the apo-siderophore, enterobactin, but does not bind ferric agrobactin (PubMed:10986237).
What are the official names of this protein?
Ferric enterobactin-binding periplasmic protein FepB.
What is the protein family that this protein belongs to?
Belongs to the bacterial solute-binding protein 8 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: GATB_METBF
Sequence: MVYENPDGVRIGLEIHIQLNKLKTKMFCGCSTDYHNAAPNTHTCPICLGLPGTLPVLNKKAVEAAIKVGLALEGEIAEETQFHRKNYFYPDLPKGFQITQYDFPIVSNGKVVIEGEDGEHTVGITRAHMEEDPGKLVHIGSIEKSKGVLIDYNRSGVPLIETVTEPDMRSPKEARRFLDKFRNILEYLDVFDGNLEGAMRVDANVSVHWGTRVEVKNISSHKGVEKALLYEIMRQKNVIRRGGKVSQETRHFDEGRGVTLSMRTKEEAEDYRYFREPDLMPMRITGWIPSIKKTLPELPDAKRARFIEQYGITDMHAKSLTSKIMLADFYESVCAKGVDPKIAATWTADVFLGELNYRDLEISSYDGKKIGFIHAKDPGIKNSIKASDMVELINLFAEGKISDRAAVEVIRTMLDAAEEKTPSQIIEEKGLFKAEDDLVTKAIAETIAENEAAVQDYIGGTEKSLNFLVGQVMKKTKGTADAKTARELIIKELKG
What is the function of this protein?
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases.  The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Asp/Glu-ADT subunit B.
What is the protein family that this protein belongs to?
Belongs to the GatB/GatE family. GatB subfamily.
Protein: ENTP2_MOUSE
Sequence: MAGKLVSLVPPLLLAAVGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKENDTGIVGQHSSCDVRGGGISSYANDPSRAGQSLVECLEQALRDVPKDRYASTPLYLGATAGMRLLNLTSPEATAKVLEAVTQTLTRYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRPRKGTLGAMDLGGASTQITFETTSPSEDPDNEVHLRLYGQHYRVYTHSFLCYGRDQVLQRLLASALQIHRFHPCWPKGYSTQVLLREVYQSPCTMGQRPQTFNSSATVSLSGTSNAALCRDLVSGLFNISSCPFSQCSFNGVFQPPVAGNFIAFSAFYYTVDFLKTVMGLPVGTLKQLEDATETTCNQTWAELQARVPGQQTRLPDYCAVAMFIHQLLSRGYRFDERSFRGVVFEKKAADTAVGWALGYMLNLTNLIPADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQVRSAKSPGAL
What is the function of this protein?
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission.  Hydrolyzes ADP only to a marginal extent (By similarity).
What are the official names of this protein?
Ectonucleoside triphosphate diphosphohydrolase 2, NTPDase 2, CD39 antigen-like 1, Ecto-ATP diphosphohydrolase 2, Ecto-ATPDase 2, Ecto-ATPase 2.
What is the protein family that this protein belongs to?
Belongs to the GDA1/CD39 NTPase family.
What are the subcellular locations of this protein?
[Isoform Long]: Cell membrane; Multi-pass membrane protein.
Protein: PTEA_BACSU
Sequence: MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEADALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEMLDLFKTKNI
What is the function of this protein?
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.  The enzyme II GmuABC PTS system is involved in the transport of oligo-glucomannans such as cellobiose or mannobiose.
What are the official names of this protein?
PTS system oligo-beta-mannoside-specific EIIA component, Glucomannan utilization protein A, Oligo-beta-mannoside-specific phosphotransferase enzyme IIA component.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IHFB_AGRVS
Sequence: MIKSELVQIVAARNPHLYHRDVENIVNAVLDEITDALASGNRVELRGFGAFSVKNRPSRTGRNPRTGDTVFVEEKWVPFFKTGKELRERLNPGMDDEDDGDAD
What is the function of this protein?
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
What are the official names of this protein?
Integration host factor subunit beta, IHF-beta.
What is the protein family that this protein belongs to?
Belongs to the bacterial histone-like protein family.
Protein: CDK4_PIG
Sequence: MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGAGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATARTDRETKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFSPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKAEGNPE
What is the function of this protein?
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition.  Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase.  Hypophosphorylates RB1 in early G(1) phase.  Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.  Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity.  Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
What are the official names of this protein?
Cyclin-dependent kinase 4, Cell division protein kinase 4.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Nucleus membrane. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus (By similarity).
Protein: ARNA_SALEP
Sequence: MKAVIFAYHDMGCQGVQAVLDAGYEIAAIFTHADNPAENTFFGSVSRLAAELGIPVYAPDNVNHPIWVDRIAELAPDIIFSFYYRNLLSEEILHLAPAGAFNLHGSLLPAYRGRAPLNWVLVNGESETGVTLHRMVKRADAGEIVASQRVAIAQDDVALTLHHKLCQAARQLLNSILPTMKCGDIPSVPQRESDATYYGRRRPEDGLIDWHKPVSTVHNLVRAVAAPWPGAFSYNGSQKFTIWSSRICPDAQGALPGSVISVSPLRVACADGALEIITGQAGDGITVQGSQLAQTLGLVAGARLNRPPATSGKRRIRVLILGVNGFIGNHLTERLLNEENYEVYGMDIGSNAISRFLLHPRFHFVEGDISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYRKRVVFPSTSEVYGMCTDASFDEDKSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKEGLRFTLFRPFNWMGPRLDSLNAARIGSSRAITQLILNLVEGTPIKLIDGGQQKRCFTDIRDGIEALFRIIVNDGDRCDGKIINIGNPDNEASIQELATLLLDSFDKHPLRCHFPPFAGFQVVESRSYYGKGYQDVAHRKPSIDNARRCLGWEPSIAMRDTVEETLDFFLRSVDVAERAS
What is the function of this protein?
Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN).  The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
What are the official names of this protein?
Bifunctional polymyxin resistance protein ArnA.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
Protein: Y2393_NOSS1
Sequence: MNLLFKDLFGIFKIFEDVYERIRKILIPTTAYSWQTFIYLSVFSWIMSYFATGYIRDIIALCGWLFLIAGTAWYTTDDPLRVPGTFMPVGAVITGFLVSVFAFSNQEDVITSRTIVLWPTISALITAIPEFIEGSDTDSKTRIPKPDARQKIIVLVASCMMISCWLQFYFVLDKWLQEYPSLLAENFGRSTFVITREEQQKIPTNGVVILDRLQPLVEEQIAERPWSEVERWLLEANVRVGQLGREVLDNNLAQYEEKVLWRVEPRVVNNKSGYRLDLLSIWTGPTANPRGYFLRKSCQIDPVATTPINTTTNSRIPEEKKAVAEIQCDRLNKLFSGAAPPQQ
What are the official names of this protein?
Uncharacterized protein alr2393.
Protein: PIMT_GEOMG
Sequence: MNFDIARKRMVETQIISRGVKDRRLIEAMLKVPRHVFVEEAMAAQAYSDTPLPIGEKQTISQPYMVALMTELLELSGREKVLEIGTGSGYQAAILATLADRVYTVERIRPLALKARRALDRLGLLNVNIKISDGTIGWEEEAPFDAIIVTAGAPDVPDKLAEQLAVGGRLVIPVGNQFDQVLVRITKQEDGSLIRENVTGCRFVKLVGKYGWGTEE
What is the function of this protein?
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues.  It plays a role in the repair and/or degradation of damaged proteins.
What are the official names of this protein?
Protein-L-isoaspartate O-methyltransferase, L-isoaspartyl protein carboxyl methyltransferase, Protein L-isoaspartyl methyltransferase, Protein-beta-aspartate methyltransferase, PIMT.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RUNT_DROME
Sequence: MHLPAGPTMVANNTQVLAAAAAAAAAAAAAVAQGPGPQQSSNATTASAIAINPAQSLANTSTHSASSTGSSTPDLSTNNTSSSSNATTSPQNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSYGYPHPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSASSVSPNPNPSVATSSSSAVQPSEYPHPAAAVAAAAGQPAAMMPSPPGAAPATPYAIPQFPFNHVAAAAAAKAATPHAFHPYNFAAAAGLRARNAALHHQSEPVHVSPASSRPSSSSPTQQHVLLKLNTSIETSSIHEQSASDGDSDDEQIDVVKSEFDLDKSLDVAPLRMRCDLKAPSAMKPLYHESGPGAVANSRQPSPETTTKIKSAAVQQKTVWRPY
What is the function of this protein?
Plays a pivotal role in regulating the expression of other pair-rule genes such as eve, ftz, and h.
What are the official names of this protein?
Segmentation protein Runt.
What are the subcellular locations of this protein?
Nucleus.
Protein: ZNF99_HUMAN
Sequence: MGSLTFWDVTIEFALEEWQCLDMAQQNLYRNVMLENYRNLVFLGIAVSKLDLITCLKQGKEPWNMKRHEMVTKPPVISSHFTQDFWPDQSIKDSFQEIILRTYARCGHKNLRLRKDCESVNEGKMHEEAYNKLNQCWTTTQGKIFQCNKYVKVFHKYSNSNRYKIRHTKKKTFKCMKCSKSFFMLSHLIQHKRIHTRENIYKCEERGKAFKWFSTLIKHKIIHTEDKPYKYKKCGKAFNISSMFTKCKIIHTGKKPCKCEECGKVFNNSSTLMKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTEEKPYKYEECGKAFSNLSALRKHEIIHTGQKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKAFKRFSALRKHKIIHTGKQPYKCEECSKAFSNFSALRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHMEEKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEECGKAFNNSSTLMKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSHLTRHKVIHTEEKPYKCEECGKAFNHFSALRKHKIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTAEKPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEECGKAFNNSSTLRKHEIIHTGEKSYKCEECGKAFQWSSKLTLHKVIHMERNPANVKNVAKLLNISQPLENMR
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 99.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: HIS6_ECOLC
Sequence: MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDGETGKYHVNQYTGDESRTRVTQWETLDWVEEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRIC
What is the function of this protein?
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate.  The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
What are the official names of this protein?
Imidazole glycerol phosphate synthase subunit HisF, IGP synthase cyclase subunit, IGP synthase subunit HisF, ImGP synthase subunit HisF, IGPS subunit HisF.
What is the protein family that this protein belongs to?
Belongs to the HisA/HisF family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SJ711_SCHJA
Sequence: MMSTQHFILSLTILIIISNLHDEVNACRELGEECVTRGPKSCCEPLICGLKSHGTGVCVKCIPGGSECKKSEDCCSKRCKSGYCKFK
What are the official names of this protein?
Uncharacterized protein SJCHGC06711.
What are the subcellular locations of this protein?
Secreted.
Protein: AMIC_ECOL6
Sequence: MSGSNTAISRRRLLQGAGAMWLLSVSQVSLAAVSQVVAVRVWPASSYTRVTVESNRQLKYKQFALSNPERVVVDIEDVNLNSVLKGMAAQIRADDPFIKSARVGQFDPQTVRMVFELKQNVKPQLFALAPVAGFKERLVMDLYPANAQDMQDPLLALLEDYNKGDLEKQVPPAQSGPQPGKAGRDRPIVIMLDPGHGGEDSGAVGKYKTREKDVVLQIARRLRSLIEKEGNMKVYMTRNEDIFIPLQVRVAKAQKQRADLFVSIHADAFTSRQPSGSSVFALSTKGATSTAAKYLAQTQNASDLIGGVSKSGDRYVDHTMFDMVQSLTIADSLKFGKAVLNKLGKINKLHKNQVEQAGFAVLKAPDIPSILVETAFISNVEEERKLKTATFQQEVAESILAGIKAYFADGATLARRG
What is the function of this protein?
Cell-wall hydrolase involved in septum cleavage during cell division.
What are the official names of this protein?
N-acetylmuramoyl-L-alanine amidase AmiC.
What is the protein family that this protein belongs to?
Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
What are the subcellular locations of this protein?
Periplasm.
Protein: MET7_YEAST
Sequence: MISRTIGESIPPNTKHAVSVCLPTWEATVGYEEGESSIINSLTTGYPRFFIHKSIKKLCEILSAKYSMEDEACLCFPSYKVANRCREFIKVKTGLSTKVRILQLCTPKPMNQEEKLWRRECKITVVFVDQEIFPVMKQYWQHSGEIVSSRMAEYILHELQVKDNLKKMETVDNGKKFMTEDENRVNEEYIETRFGRNLNFLAADKAKYLIRKRIATKVVEKIDSEGLSDLFSFEHYNESNGPFNVGSGEALDDDQLNSDIPAETITSMGESGSNSTFENTATDDLKFHVNPNTDVYLFPSGMASIFTAHRLLLNFDAKRLSRSSSRQDKLIGYGPPFKKTVMFGFPYTDTLSILRKFNHTHFLGQGDSTSMNALKNILHSGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPYADIVCSSLTKIFSGDSNVIAGSLVLNPRGKIYEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILLKRVLLPQVGKLFKKIYYPSLTSEDTKRNYDSVMSTKDGGYGGLFSLTFFNIEEAKKFFNNLELCKGPSLGTNFTLACPYAIIAHYQELDEVAQYGVETNLVRVSVGLENSDVLCNVFQRAIEKALGE
What is the function of this protein?
Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction.  In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.
What are the official names of this protein?
Cystathionine gamma-synthase, O-succinylhomoserine (thiol)-lyase, Sulfur transfer protein 2.
What is the protein family that this protein belongs to?
Belongs to the trans-sulfuration enzymes family. MET7 subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL2_CLOK5
Sequence: MAVKGFKPTTPSRRHMTVNTFEEITTDIPEKSLLVALKRSGGRNAHGKITVRHIGGGAKRKYRIIDFKRNKDGIPAKVSTIEYDPNRSAFIALVTYADGEKRYIIAPVGLKVGDVIVSGADSDIKVGNCLPIVNIPVGTTIHNIELQAGKGAQLVRSAGTSAQLMAKEGKYATLRLPSGEVRYVRIECRATIGTVSNLTHEIINIGKAGRKRHMGIRPTVRGSVMNPNDHPHGGGEGKSPVGHPGPLTPWGKPALGLKTRKNKKYSDKFIIKRKNKK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: OPSD_NEOAR
Sequence: TEGPYFYVPMVNTTGIVRSPYEYPQYYLVNPAAYAVLGAYMFFLIILGFPINFLTLYVTLEHKKLRTPLNYILLNLAVADLFMVIGGFTTTMYSSMHGYFVLGRLGCNLEGFSATLGGMISLWSLAVLAIERWVVVCKPISNFRFGENHAIMGVSLTWTMALACTVPPLVGWSRYIPEGMQCSCGIDYYTRAEGFNNESFVLYMFFCHFMVPLIIIFFCYGRLLCAVKEAAAAQQESETTQRAEREVTRMVILMVIGYLVCWLPYASVAWFIFTHQGSEFGPLFMTIPAFFAKSSSIYNPVIYICMNKQFRNCMITTLFCGKNPFEGEEEGASSTKTEASSASSVSPA
What is the function of this protein?
Photoreceptor required for image-forming vision at low light intensity.  While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity).  Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins.  Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity).
What are the official names of this protein?
Rhodopsin.
What is the protein family that this protein belongs to?
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
What are the subcellular locations of this protein?
Membrane; Multi- pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.
Protein: BIOB_LEPCP
Sequence: MTTATISLSTLQASRPSVAARADAAARWRVADVEALYALPFMDLLFQAQQVHRAHFDANEVQLSTLLSIKTGGCAEDCGYCPQSAHFDTAVEASKLMPIDEVLDAANAAKAQGATRFCMGAAWRSPKERDMERVTEMVREVRALGLETCMTLGMLDGEQARELKDAGLDYYNHNLDSAPDFYGQVISTRTYQDRLDTLGNVRDAGINVCCGGIVGMGESRTQRAGLIAQLANLSPYPESVPINNLVPVPGTPLADAEPIDPFEFVRTIAVARITMPTTMVRLSAGREQMDEALQALCFAAGANSIFYGDKLLTTSNPQAARDRALFERLGLRVQGERPAVRTSDN
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: NTPP_NITWN
Sequence: MAIWRGSEPLILASQSRVRQLLLANAGLPFETMPAAIDERAVQRSSGLTTAGEIAVRLACEKAREVSSRSPGRYVIGADQTLECDGRLLNKPAGRADAGAHLRALSGRTHALHAGVAVVRDGRLMFENVSVARMTMRELSEDTIESYLDAAGDAASASVGAYQLEGLGIHLFSRIEGDHFTILGLPLLPLLAYLRSQWLLSL
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MODC_SALCH
Sequence: MLELNFSQTLGTHCLTLNETLPASGITAIFGVSGAGKTSLINAISGLTRPQKGRIALNGRVLHDAENGICLTPEKRRIGYVFQDARLFPHYKVRGNLRYGMAKSMTGQFDKLVSLLGIEALLDRLPGSLSGGEKQRVAIGRALLTAPELLLLDEPLASLDIPRKRELLPYLQRLAREINIPMLYVSHSLDEILHLADKVMVLEDGQVKAFGPLEEVWGSSVMHPWLPKEQQSSILKVSVLEHHPHYAMTALALGDQHLWVNKLNQPLQSTLRIRIQASDVSLVLQPPQQTSIRNVLRAKVANCYDDNGQVEVQLEIGGRTLWARISPWARDELNIKPGLWLYAQVKSVSITA
What is the function of this protein?
Part of the ABC transporter complex ModABC involved in molybdenum import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Molybdenum import ATP-binding protein ModC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: GATA2_CHICK
Sequence: MEVATDQPRWMTHHAVLNGQHPESHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANSAHARARVSYSQAHARLTGSQMCRPHLIHSPGIPWLDSSKAALSAHHHNPWTVNPFTKTPLHPSAAGAPGAISVYPGSSTSSTASVSSLTPASHSGSHLFGFPPTPPKEVSPDPNSTSAASPSSSAGARQEDKDSIKYQVSLSEGMKMESASPLRSSLTSMGAQPSTHHPIPTYPSYVPAAHDYSSSLFHPGSFLGGPASSFTPKPRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGSECFEELSKCMQEKSSPFSAAALASHMAPMGHLPPFSHSGHILPTPTPIHPSSSISFGHPHPSSMVTAMG
What is the function of this protein?
Transcriptional activator which probably serves as a general switch factor for cell-specific development.  It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.
What are the official names of this protein?
GATA-binding factor 2, GATA-2, Transcription factor NF-E1b.
What are the subcellular locations of this protein?
Nucleus.
Protein: HSP12_MEDSA
Sequence: MSLIPSFFGGRRSNVFDPFSLDVWDPFKDFPFNNSALSASFPRENSAFVSTRVDWKETPEAHVFKADLPGMKKEEVKVEIEDDRVLQISGERSVEKEDKNDQWHRLERSSGKFMRRFRLPENAKMDQVKAAMENGVLTVTVPKEEVKKPEVKTIDISG
What are the official names of this protein?
18.2 kDa class I heat shock protein.
What is the protein family that this protein belongs to?
Belongs to the small heat shock protein (HSP20) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PQQC_ACIB5
Sequence: MTQTPEALTTEQFKQAIIDKGQYYHIYHPFHVMMYEGKATQQQIQAWVANRYYYQINIPLKDAAIMANCPDQRVRQEWIQRMIDQDGEYPDGGGREAWLRLAEAVGLSREQVISEELVLPGVRFAVDAYVNFARRASWREAASSSLTELFAPQIHQSRLESWPQHYPWIDDKGYEYFRSRLSQARRDVEHGLTITLDSFTTHEQQQRMLEILQFKLDILWSILDALTLAYVHNEAPYHSVTQERVWHKGLFK
What is the function of this protein?
Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.
What are the official names of this protein?
Pyrroloquinoline-quinone synthase, Coenzyme PQQ synthesis protein C, Pyrroloquinoline quinone biosynthesis protein C.
What is the protein family that this protein belongs to?
Belongs to the PqqC family.