PharMolix/UniProtQA huggingface dataset:
Protein: YEEF_BACSH
Sequence: MKVLEVKTLLSEATDRAKEYKELRTQMVNLRKALKSVADLGDSEFSGKGASNIKAFYHDHVGVTDQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEHELANAHKKSKSIMSEQKKAMKDILNDIDNILPLDLFSTETFNDELADANDKRKKTLEKLDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKKGDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQRYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAVAHPIKTYEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTATKVTTKVKTAASKSATAQKAITVSKQTIDHIKQKVNKGIEVSKKHVKTKLNQIGDLTLADILPYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPVVPPVTVKYGEHYARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQSHAGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGRWYEMEQEWAKALKEEPPQKVNVNIKAIYKGDSLRPDKFIVKFRIGDADFEKVTIKNQSGG
What is the function of this protein?
Toxic component of an LXG toxin-immunity module (PubMed:32117125).  These modules promote kin selection, mediate competition in biofilms, and drive spatial segregation of different strains, indicating that LXG toxins may help avoid warfare between strains in biofilms (By similarity).  The C-terminus (residues 527 to 669) has DNase activity in E. coli and in vitro, and inhibits growth upon expression in E. coli; does not have RNase activity.  Acts on supercoiled, genomic, linear and nicked DNA.  By 2 hours post-induction cells have an irregular surface, membrane disruption and elongate.  All toxic effects in E. coli are neutralized by cognate immunity protein YezG.  Binds DNA in the presence and absence of YezG; substrate-binding and immunity protein-binding must occur at distinct sites on the toxin (PubMed:32117125).
What are the official names of this protein?
Toxin YeeF, DNase YeeF.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the LXG family.
What are the subcellular locations of this protein?
Cell membrane. Membrane raft. Note=Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion. Delivery to target cells requires the type VII secretion system (T7SS) and YukE.
Protein: TLR2_MACMU
Sequence: MPHTLWMVWVLGVIISLSKEESSNQASLSCDHNGICKGSSGSLNSIPSVLTEAVKCLDLSNNRITYISNSDLQRYVNLQALVLTSNGINTIEEDSFSSLGRLEHLDLSYNYLSNLSSSWFKPLSSLKFLNLLGNPYKTLGETSLFSHLTKLRILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDLTSSVECLELRDTDLNTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLSQISGLLELEFDDCTLNGVGDFRGSDNDRVIDPGKVETLTIRRLHIPQFYSFNDLSTLYPLTERVKRITVENSKVFLVPCLLSRHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLGKIGETLLTLKNLTNLDISKNTFHYMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDISNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNTITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLVDWPANYLCDSPSHVRGQRVQDVRLSVSECHRAALVSGMCCALFLLILLMGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPNRDICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILVLLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEARQEGFWVNLRAAIKS
What is the function of this protein?
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components.  Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.  Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  May also promote apoptosis in response to lipoproteins.  Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway.  Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
What are the official names of this protein?
Toll-like receptor 2.
What is the protein family that this protein belongs to?
Belongs to the Toll-like receptor family.
What are the subcellular locations of this protein?
Membrane; Single- pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.
Protein: MSHD_PAEAT
Sequence: MSHAHPENWPVLIIAGALDTELLRDVKTLAAAAGESDGNPPFSEQTLVTLRGADAGDHSVLSFVLYAPDEDSDPATAEDLAGVAVVVENGDESGVLELAVHPSYRNQGVAGRLLDALQGKRGLGGLSAWSHGNHEAAAELATRFGYGPVRELWKMRLMSSTSALPDAGLPDGVSLRAFVPGQDEQAWLTANSAAFSHHPEQGSMTRADLEARKAEDWFDPEGFLLAVNAEGELLGFHWTKVHPRQGPHPAIGEVYVVGVTPEAQGLGLGKALTVAGIKHLQDQGLHAVMLYVDADNEAAVALYQKLGFVRWDTDVMYGPLTKN
What is the function of this protein?
Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
What are the official names of this protein?
Mycothiol acetyltransferase, MSH acetyltransferase, Mycothiol synthase.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family. MshD subfamily.
Protein: YQ86_SCHPO
Sequence: MQGKINYKDITQKEMFNEIFKEYVKEEKQIDLGTCDQDSVHDLWRRFVKRWNDGKMKSKWYSLGKRISQPSYARLVGPSRPTLENLQDRRELQEQLNELRKLSRKSAFKSQAKRETELLDEILPKEPAGSKEAMQQKKKEKRAALKHYREASDNEEDLKETDLYGDRDSFQSRLKQKKQRSEFRASKREMERLERDQELRNKIEERNKKELETIEKLRELAKARLQGFSS
What are the official names of this protein?
Uncharacterized protein C297.06c.
Protein: FABZ_BARQU
Sequence: MINTEGTKSLEAVDIEELLSILPHRYPFLLIDRIVEIDGEQQAIGIKNITINEPHFMGHFPAKPVMPGVLILEAMAQTAGAISLLRLGNKQTNLVYLMTVDNAKFRKPVIPGDQLKIHVRLLKKRSGMRRFSCVAEVEGVRVAEAEIAAMIIEAE
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ATPH_THAPS
Sequence: MDSIISAASVIAAGLAIGLAAIGPGIGQGNAAGQAVEGIARQPEAENKIRGTLLLSLAFMEALTIYGLVVALALLFANPFNS
What is the function of this protein?
Key component of the F(0) channel; it plays a direct role in translocation across the membrane.  A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
What are the official names of this protein?
ATP synthase subunit c, chloroplastic, ATP synthase F(0) sector subunit c, ATPase subunit III, F-type ATPase subunit c, F-ATPase subunit c, Lipid-binding protein.
What is the protein family that this protein belongs to?
Belongs to the ATPase C chain family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
Protein: PMEL_HUMAN
Sequence: MDLVLKRCLLHLAVIGALLAVGATKVPRNQDWLGVSRQLRTKAWNRQLYPEWTEAQRLDCWRGGQVSLKVSNDGPTLIGANASFSIALNFPGSQKVLPDGQVIWVNNTIINGSQVWGGQPVYPQETDDACIFPDGGPCPSGSWSQKRSFVYVWKTWGQYWQVLGGPVSGLSIGTGRAMLGTHTMEVTVYHRRGSRSYVPLAHSSSAFTITDQVPFSVSVSQLRALDGGNKHFLRNQPLTFALQLHDPSGYLAEADLSYTWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLTSCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTTEVISTAPVQMPTAESTGMTPEKVPVSEVMGTTLAEMSTPEATGMTPAEVSIVVLSGTTAAQVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDGTATLRLVKRQVPLDCVLYRYGSFSVTLDIVQGIESAEILQAVPSGEGDAFELTVSCQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKGGSGTYCLNVSLADTNSLAVVSTQLIMPGQEAGLGQVPLIVGILLVLMAVVLASLIYRRRLMKQDFSVPQLPHSSSHWLRLPRIFCSCPIGENSPLLSGQQV
What is the function of this protein?
Represents a potent melanoma-specific antigen.  Among melanoma non-mutated self-peptides, G9-154 (KTWGQYWQV), G9-209 (ITDQVPFSV) and G9-280 (YLEPGPVTA), appear to act as immunodominant common epitopes that stimulate anti-tumor immune response mediated by HLA-A-restricted cytotoxic T cells.
What are the official names of this protein?
Melanocyte protein PMEL, ME20-M, ME20M, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, Premelanosome protein, Silver locus protein homolog.
What is the protein family that this protein belongs to?
Belongs to the PMEL/NMB family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus. Melanosome. Endosome, multivesicular body. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes predominantly to intralumenal vesicles (ILVs) within multivesicular bodies. Associates with ILVs found within the lumen of premelanosomes and melanosomes and particularly in compartments that serve as precursors to the striated stage II premelanosomes. SUBCELLULAR LOCATION: [M-alpha]: Secreted.
Protein: ATPF_XANAC
Sequence: MDITLTIFAQALAFAGLIWIVATKIWPPLLQAIEERQQKIAEGLAAADRSQKDLAQAQEKVNEALKDARTKANEIIDQAHARANQIIEAAKLEAIAEANRQKDLAQTEIDASATRAREELRKQVSVLAVSGAEKLLKREIDANAHKALLDELAAEI
What is the function of this protein?
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
What are the official names of this protein?
ATP synthase subunit b, ATP synthase F(0) sector subunit b, ATPase subunit I, F-type ATPase subunit b, F-ATPase subunit b.
What is the protein family that this protein belongs to?
Belongs to the ATPase B chain family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: RPOZ_PEDPA
Sequence: MILYPSVDDLLERVDSRYSLIMLASKRAHQLDEGQPELLDKYTSQKNVGKALEEVVAGDVIIDPNEKDL
What is the function of this protein?
Promotes RNA polymerase assembly.  Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
What are the official names of this protein?
DNA-directed RNA polymerase subunit omega, RNAP omega subunit, RNA polymerase omega subunit, Transcriptase subunit omega.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase subunit omega family.
Protein: PSF1_MOUSE
Sequence: MFCEKAMELVRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSAGRGDLIPTVKFRHCALLRNRRCTIAYLYDRLLRIRALRWEYGSVLPNSLRFHMSAEETEWFNHYKKSLATYMRSLGGDEGLDITQDVKPPKSLYIEVRCLKDYGEFEVDDGTSVLLKKNSQHFLPRWKCEQLIRQGVLEHVLS
What is the function of this protein?
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks.  GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
What are the official names of this protein?
DNA replication complex GINS protein PSF1, GINS complex subunit 1.
What is the protein family that this protein belongs to?
Belongs to the GINS1/PSF1 family.
What are the subcellular locations of this protein?
Nucleus. Chromosome. Note=Associates with chromatin.
Protein: LEXA_BURM7
Sequence: MIKLTARQQQVFDLIRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAAGASRGIRLLGIDDAPHQLTLPHAALMQLSLPLVGRVAAGSPILAQEHISQHYACDPALFSSKPDYLLKVRGLSMRDAGILDGDLLAVQKRTEAKDGQIIVARLGDDVTVKRLKRRPGGVELIAENPDYENIFVKAGSAEFALEGIAVGLIRPGEF
What is the function of this protein?
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA.  In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
What are the official names of this protein?
LexA repressor.
What is the protein family that this protein belongs to?
Belongs to the peptidase S24 family.
Protein: ANO9_HUMAN
Sequence: MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRIRIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARSTDV
What is the function of this protein?
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity).  Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22178883).  Can inhibit the activity of ANO1 (PubMed:20056604, PubMed:22946059).
What are the official names of this protein?
Anoctamin-9, Transmembrane protein 16J, Tumor protein p53-inducible protein 5, p53-induced gene 5 protein.
What is the protein family that this protein belongs to?
Belongs to the anoctamin family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Protein: UBIA_XANOM
Sequence: MSKHDVERLPAACGLTCPQRLGQYWQLVRGDRPIGSLLLLWPTWWALWLAADGLPPLWTLFVFTAGVWLTRSAGCVINDYADRWLDPHVERTKSRPLATGAVSGREALWVFVVLMLVAFALVFTLNWLTVLLSVPGVFLAASYPYLKRHTHLPQVYLGMAFGWGIPMAFAAVQGSVPVLGWLLYAANILWATAYDTWYAMVDRDDDIRMGSKSTAILFGRFDLVAQGILYALMFAVLALVDLRADLGAAYWAGLGVAALLVAYEFRIARHRERGPCFRAFLHNNWVGLAIFVGIAVAGR
What is the function of this protein?
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group.  Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
What are the official names of this protein?
4-hydroxybenzoate octaprenyltransferase, 4-HB polyprenyltransferase.
What is the protein family that this protein belongs to?
Belongs to the UbiA prenyltransferase family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: NUCS_MYCS2
Sequence: MRLVIAQCTVDYVGRLTAHLPSARRLLLFKADGSVSVHADDRAYKPLNWMSPPCWVTEQDTETGVALWVVENKTGEQLRITVEDIEHDSHHELGVDPGLVKDGVEAHLQALLAEHVELLGAGYTLVRREYPTPIGPVDLLCRDELGRSVAVEIKRRGEIDGVEQLTRYLELLNRDSLLAPVAGVFAAQQIKPQARTLATDRGIRCVTLDYDQMRGMDSDEYRLF
What is the function of this protein?
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
What are the official names of this protein?
Endonuclease NucS.
What is the protein family that this protein belongs to?
Belongs to the NucS endonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FLGC_BORHE
Sequence: MGLFSSINTASTGLTAQRLRLDVIANNIANVETTRTSEGGSYRRQRVIFAPRVVSPYWK
What are the official names of this protein?
Flagellar basal-body rod protein FlgC.
What is the protein family that this protein belongs to?
Belongs to the flagella basal body rod proteins family.
What are the subcellular locations of this protein?
Bacterial flagellum basal body.
Protein: RS3A_PHANO
Sequence: MAVGKNKRLSKGKKGLKKKTDTFAKKDWYNVKAPGTFAIRDVGKTLVNRTTGLKNANDALKGRIFEVSLADLQKDEDHAFRKVKLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQTLIEANVVVKTTDDYLLRLFAIGFTKRRPNQIKKTTYAASSQIRAIRKKMVEIMTRDASSCTLAQLTQKLIPEVIGREIEKSTQGIYPLQNVHVRKVKLLKAPKFDLGALLGLHGESSADDSGQKVEREFKETVLNEV
What are the official names of this protein?
40S ribosomal protein S1.
What is the protein family that this protein belongs to?
Belongs to the eukaryotic ribosomal protein eS1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NUPL_DICDI
Sequence: MNGRIRQNQTAYNPYSTSGRNNRNTINSERDESENGSLLMNGSSSPPNNQQTNKAGFFKNMVSKLLSKPLQWMFSNFDESSSSSSSSSSSYDDGNNIPQKGSSTTTTNINNNNNNNNSNSNSNSNNNTNNQNNNSNNNNNNNNKINISDDYDSNLSKVKVPSGINFDTSSLSVADLTRSYQTNISNKNILDNKPILKKDQNPTTTTTTTTAAAVPKKSVAIGGVTNNDKKPTTTTTATTSILKTNINSLYPNLSQDRINANASTFNSSRNIKNNLSPTQTTLKITNNNTIYSNSQFKKKPISSTFNASPFESSIINSSSILSKRKQFDDNNNSNINDNQSIYNRQSIYSPNSKIEQPPLKKRLPNADGTDNSVMMATSQAAKRILEHLDSFSNPVLAHYNPSSTMAPSSQSLYNGNDSTYQPPTSVYRPKIKIPQISINYKYNPYGLSKLLEKKPKSNKDLGLEIPTNSITSSVSLYKKPLNKKSEDESTEPIKTYATPSTTTTTATVANTSSSSSSSSSSSSSSSSSSSSSSSSSSLFSSKPATISSNTTTTTTTSSPPSSSLFSTTSSAASTNTATASSLFSATPATTIATSSPSTSTSTSSSSSGNEKKLDNMFTSDSNKSNLFSKENDGGGVNPFKNLATTVSKTDFIGINGVSTSTSSSTSTSKSSPIAKKDITSINKSAPYEKKKRGLENEDTPLDVPGLKNIEPPSGLFNFSGIKPIETTLFSVSTTTPLATTTTASSSSSSSLFSSPPTTDKSSADKSSADKSSTDKSTSPVTTSIPSFTSSSTSTSLFGPTTTTTDKDSKTASIFSTKPTTEGLFSKPTTSLTSSSLFSSTITTATTTPSIFGDASKSSTSTSLFGSSNTTTAKPPASFGVNLSAAPKKSSPPPPPESDEEDEENEGDEGDEEGDENGELEAEEAFYVPPDSDEENEGDGNGGDLEAEEEFYVPPDSDEEKEKEKKPKTKQQSTQLTGLFAAPPKGGSLFGNTPTGGSLFGSAPTGSSLFSGGSLLTSSFLTKKGENDDDSSDEDSNKKRKKKRESSSSSSTSSNIIIPTTSKKEKIDDKPSTTTTTTTTSLFGSTTTSGLFSNPSTTSTGSLFSSNPLGSTASTSSLFGASTLASTATTTATPTTSLFGSTTPSSSSSSSSSSSSTTSTTTPSNSLFGTSSSSSSTSSSLFGSTTSATTPSSLFGTTTTSSDSKSETKTTPSLSSGGLFSTTSASPFSIPSSTSSSGLFGSTNQTESKVATTTTTAATTATPSTSLFGSTTTPSTSSSTSSLTTTPSTGLFGASSSTTPSTGLFGSATTPSTGLFGASSSSSSSSISSSSTTSTTTTPSTGLFGSTTPSTGLFGSTTTAATTTPSTGLFGSTPSSTTSTTTTPPNGLFGSTTPSTALFGTSTPATTSTLTTSTSTTPSTGLFGSSSSIATTTPSTGLFGSTSSSTTNTAPSTGLFGSTTTSTTATPFGSSSSTPSTGLFGSSSSSTSSSLSSSSTTATQPTGLFGSTAPSTGLFGSTTATNPSTGLFGSTTTTSTTTTPSTGLFGSSSSTPSSTGLFGSSSSTTSSTTTPSTGLFGSAAPSTSSPFSIPTSSTPATSNPFGSNPFPTSSPTTVSSTPSSNPFGAPSLSNSTSSSSLFGAPTTSTAATTTPSFGSSPFGAPSSTSSTPFGASPFGAPTSTSSPPFGAPTSASSTPFGAPQISTSSSTNLFGGASSSTAAPSFVSSPFGAPITSSSSSSSSSLPFGAPTTSSSSSTPFGASPFGNSMASTTSPFGAPAASPSPFGIQAASPSPFGAPAASPSPFGSTPSTAPNPFGNFGAVPANGFSLGKMGTSKKPAKKK
What are the official names of this protein?
Nuclear pore complex protein DDB_G0274915.
Protein: YDFG_ECOLI
Sequence: MIVLVTGATAGFGECITRRFIQQGHKVIATGRRQERLQELKDELGDNLYIAQLDVRNRAAIEEMLASLPAEWCNIDILVNNAGLALGMEPAHKASVEDWETMIDTNNKGLVYMTRAVLPGMVERNHGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLNLRTDLHGTAVRVTDIEPGLVGGTEFSNVRFKGDDGKAEKTYQNTVALTPEDVSEAVWWVSTLPAHVNINTLEMMPVTQSYAGLNVHRQ
What is the function of this protein?
NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids.  Catalyzes the NADP-dependent oxidation of L-allo-threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone.  Also acts on D-threonine, L-serine, D-serine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L-glycerate (PubMed:12535615).  Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid.  YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde (PubMed:20400551).
What are the official names of this protein?
NADP-dependent 3-hydroxy acid dehydrogenase YdfG, L-allo-threonine dehydrogenase, Malonic semialdehyde reductase.
What is the protein family that this protein belongs to?
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein: PROB_LACLA
Sequence: MIMTRKNILSVKRIVVKIGTSSLILPNGKINLSNIDELAFVLSDLNNKGYEVILVTSGAIGVGLNVLGIDKRPKGIADQQALASIGQVELMSLYTQMFRRYSQKVSQLLLTRDVTDFPTSRENAENALNALLGLGIIPIINENDAIAVDEMDHQTKFGDNDKLGAIVSKLVNADLLIMLSDIDGLFDKNPSIYDDAKIFNEIHEITDELRQMAGGAGSRFGTGGMTSKLAAAQILFENGQEMVLTNGERIREIKEIIEGREIGTYFHQKS
What is the function of this protein?
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
What are the official names of this protein?
Glutamate 5-kinase, Gamma-glutamyl kinase, GK.
What is the protein family that this protein belongs to?
Belongs to the glutamate 5-kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: FBX38_MOUSE
Sequence: MGPRKKSAKVCVMDSEVAEEMTADEEKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDSSFLTLLKKMPDVEQLYGLHPRYLERRRVRGQEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWMRLVDINLVRCHALKLDSFGQFVELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAPNNNANLHDNNHHHPDDSDDDNDFRPDLQAGEAQFAADALNEMEDMVQEDGELVAESGNGMPAHNREVLPVDADEEQAGPSGLQRVVKPTPIADHDSESDDEEDSLELQEVWAPKNGTRRYSEREEKTGDSGQSRETAVSGKGKTPLRKRCNNSHQTGQAKPFPLEESSCEKGCQVTSEQIKADMKAARDVSEKKKSKDVYPSCSSSSSSTAASTAGNASSPSTASQSPDFARTVTSSGSSEPSPPEVDVSRQCVCSPGGSEDSEAMEEGDAESSVCPRCCCLRPQESQRRTGRCSDEERPSTSRACVVNGADGTRSAFSFRTLPQGGSSGPAHDERTNGSGCGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVPLISESEVAKTKPCHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRNWMDTIANINQELIKYEFFLEATRTEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRTAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKRGIFQRVVAIFIHYCDVNGEPVEDDYI
What is the function of this protein?
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606).  Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606).  May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (PubMed:14729953, PubMed:16990251).
What are the official names of this protein?
F-box only protein 38, Modulator of KLF7 activity, MoKA.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Nucleus. Note=Accumulates predominantly in the cytosol (PubMed:16990251). Exported from the nucleus in a XPO1/CRM1- dependent manner (PubMed:16990251).
Protein: PSAB_SYNJB
Sequence: MTTATRFPQFSQDLASDPTTRRLWYGIATAHDFETHDGMTEERLYQKLFATHFGHLAIIFLWASGNVFHIAWQGNYEQWVANPTGVTPIAHAIWDPHFGKAAVEAFTQPGGGGPVNAAYSGLYYWFNTIGLRTNGDLYAGAIGLLLLAAVFLFAGWLHLQPRFRPSLSWFKNAEARLNHHLAGLFGVSSLAWTGHLVHVAIPESRGQHVGWDNFLTTLPHPAGLKPFFTLNWGVYAQNPDTANHVWGTAEGAGTAILTFLGGFNPNTQSLWLTDMAHHHLAIAVIFIVAGHMYRTNWGIGHSIREILGAHNPPKGTPFGGLLGEGHKGLYDTVNNSLHFQLALALACLGVVTSLVAQHMYALNPYVFMSMDHTTEAALYTHHQYIAGFLMVGAFAHGAIFLVRDYDPEANKNNVLARVLDHKEAIISHLSWVSLFLGFHTLGLYVHNDVMQAFGTPEKQILIEPVFAQFIQASHGKMIYGMDVLLSNPDSLASTAWPNYGNVWLPGWLQAINDPNGSLFLPIGPGDFLVHHAIALGLHTTTLILVKGALDARGSKLMPDKKDFGYSFPCDGPGRGGTCDISAWDAFYLAMFWMLNTIGWVTFYWHWKQLGVWSGNTAQFNENSTYLMGWLRDYLWANSAQLINGYNPYGMNNLAVWAWMFLFGHLVWATGFMFLISWRGYWQELIETLVWAHERTPLAKLIRWKDKPVAMSIVQGRLVGLAHFTVGYVLTYAAFVIASTASQSG
What is the function of this protein?
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX.  PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn.  Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
What are the official names of this protein?
Photosystem I P700 chlorophyll a apoprotein A2, PsaB.
What is the protein family that this protein belongs to?
Belongs to the PsaA/PsaB family.
What are the subcellular locations of this protein?
Cellular thylakoid membrane; Multi-pass membrane protein.