PharMolix/UniProtQA huggingface dataset:
Protein: CH25H_PIG
Sequence: MSGHNNSELFVLCSSSQLFLQPLWDHLKTWETLILSPFFPVFFSITTYLGFCLPFVVLDVLCPWVPALRRYKIHPDFSPSVWQLLPCLGLTLYQHVVFVFPMTLLHWAASPVLLPPEAPELLQLVRHIVLCLLLFDTEFFIWHVLHHKVPWLYRTFHKMHHQNSSSFALATQYMSVGELLSLGVFDMVNIMLLRCHPLTVLIFHVINIWLSVEDHSGYDFPWSAHRLVPFGWYGGVTHHDLHHSQFNCNFAPYFTHWDKILGTLRSAHAK
What is the function of this protein?
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (By similarity).  Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity).  May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing.  As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses.  Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts virus-host membranes fusion which inhibits virus replication (By similarity).  In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation (By similarity).  Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (By similarity).
What are the official names of this protein?
Cholesterol 25-hydroxylase, Cholesterol 25-monooxygenase.
What is the protein family that this protein belongs to?
Belongs to the sterol desaturase family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: PSBT_PINTH
Sequence: MEALVYTFLLVSTLGIIFFAIFFREPPKLPTKGGK
What is the function of this protein?
Seems to play a role in the dimerization of PSII.
What are the official names of this protein?
Photosystem II reaction center protein T, PSII-T.
What is the protein family that this protein belongs to?
Belongs to the PsbT family.
What are the subcellular locations of this protein?
Plastid, chloroplast thylakoid membrane; Single-pass membrane protein.
Protein: MURI_FRASN
Sequence: MSGAPIGVFDSGVGGLTVARAILDQLPGESLLYIGDTAHAPYGPRPIAEVRRYALAALDELVSAGVKLLVIACNSASAACLRDARERYDVPVVEVIVPATRRAVAATRSGRVGVIGTVATITSRAYEDAFAAAAGTELVSVACPAFVDFVERGITSGRQLLGLTEAYLAPLQEADVDTVILGCTHYPLLTGVIGLVMGEGVTLVSSAEETAKDTYRVLARDGLFRDPDLPPPAHRFLTTGDPAAFARVGRRFLGPEITAVSIAPAAAPRQAQAVGR
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: CH60_HAEIN
Sequence: MAAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRHVILDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVSAVVSELKNLSKPCETAKEIEQVGTISANSDSIVGQLISQAMEKVGKEGVITVEDGTGLEDELDVVEGMQFDRGYLSPYFINKPETATVELDNPYLLLVDKKISNIRELLPVLEGVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEDLGQAKRVVINKDNTTIIDGIGDEAQIKGRVAQIRQQIEESTSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALVRAAAKVAASLKGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVASAVKNGEGNFGYNAGTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKDDKADLGAAGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB5A_ARATH
Sequence: MKLDTSGFETSMPMIGFGSSSDMLDELSSVPSFDLPRTKEFDGFQKKAKDMLKHAKGTTTLAFIFKGGVMVAADSRASMGGYISSQSVKKIIEINPYMLGTMAGGAADCQFWHRNLGIKCRLHELANKRRISVSGASKLLANMLYSYRGMGLSVGTMIAGWDETGPGLYYVDNEGGRLKGDRFSVGSGSPYAYGVLDSGYKYDMSVEEASELARRSIYHATFRDGASGGVASVYHVGPEGWTKLSGDDVGELHYHYYPVAPATAEQVMEEATAE
What is the function of this protein?
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.  The proteasome has an ATP-dependent proteolytic activity.
What are the official names of this protein?
Proteasome subunit beta type-5-A, 20S proteasome beta subunit E-1, Proteasome component E, Proteasome epsilon-1 chain.
What is the protein family that this protein belongs to?
Belongs to the peptidase T1B family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RAE1_ARATH
Sequence: MATFGAPATANSNPNKSYEVTPSPADSISSLSFSPRADILVATSWDNQVRCWEISRSGASLASAPKASISHDQPVLCSAWKDDGTTVFSGGCDKQAKMWPLLSGGQPVTVAMHEGPIAAMAWIPGMNLLATGSWDKTLKYWDTRQQNPVHTQQLPDKCYTLSVKHPLMVVGTADRNLIVFNLQNPQTEFKRIQSPLKYQTRCVTAFPDQQGFLVGSIEGRVGVHHLDDSQQSKNFTFKCHRDGNDIYSVNSLNFHPVHGTFATAGSDGAFNFWDKDSKQRLKAMSRCNQPIPCSSFNHDGSIYAYAACYDWSKGAENHNPATAKSSIFLHLPQESEVKAKPRVGATGRK
What are the official names of this protein?
Protein RAE1, RNA export factor 1.
What is the protein family that this protein belongs to?
Belongs to the WD repeat rae1 family.
What are the subcellular locations of this protein?
Nucleus envelope. Nucleus, nuclear pore complex.
Protein: YIDD_ACIB3
Sequence: MVRILRWFIRLYQIAISPLLGPRCRYIPTCSQYALEALQTHGAIKGVWLSSKRICRCHPWGGSGYDPVPPKAIRFISFHQIDSQTHHVAVPFRDRLMKQNLSNHLG
What is the function of this protein?
Could be involved in insertion of integral membrane proteins into the membrane.
What are the official names of this protein?
Putative membrane protein insertion efficiency factor.
What is the protein family that this protein belongs to?
Belongs to the UPF0161 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: RPC2_DROME
Sequence: MVELKMGDHNVEATTWDPGDSKDWSVPIKPLTEKWKLVPAFLQVKGLVKQHIDSFNHFINVDIKKIVKANELVTSGADPLFYLKYLDVRVGKPDIDDGFNITKATTPHECRLRDTTYSAPITVDIEYTRGTQRIKRNNLLIGRMPLMLRCSNCALTGKSEFELSKLNECPLDPGGYFVVRGQEKVILIQEQLSWNKMLTEDFNGVVQCQVTSSTHEKKSRTLVLSKHGKYYLKHNSMTDDIPIVVIFKALGVVSDQEIQSLIGIDSKSQNRFGASLIDAYNLKVFTQQRALEYMGSKLVVKRFQSATTKTPSEEARELLLTTILAHVPVDNFNLQMKAIYVSMMVRRVMAAELDKTLFDDRDYYGNKRLELAGSLLSMMFEDLFKRMNWELKTIADKNIPKVKAAQFDVVKHMRAAQITAGLESAISSGNWTIKRFKMERAGVTQVLSRLSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTEVEERPVMIVAFNAGVEDIREVSGNPINNPNVFLVFINGNVLGLTLNHKHLVRNLRYMRRKGRMGSYVSVHTSYTQRCIYIHTDGGRLCRPYVIVENRRPLVKQHHLDELNRGIRKFDDFLLDGLIEYLDVNEENDSFIAWNEDQIEDRTTHLEIEPFTLLGVCAGLVPYPHHNQSPRNTYQCAMGKQAMGMIGYNQKNRIDSLMYNLVYPHAPMVKSKTIELTNFDKLPAGQNATVAVMSYSGYDIEDALILNKASIDRGYGRCLVYKNSKCTVKRYANQTFDRIMGPMKDALTNKVIFKHDVLDTDGIVAPGEQVQNKQIMINKEMPAVTSMNPLQGQSAQVPYTAVPISYKGPEPSYIERVMVSANAEEDFLIKILLRQTRIPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDFGICPDMIMNPHGFPSRMTVGKTLELLGGKAGLLEGKFHYGTAFGGSKVEDIQAELERHGFNYVGKDFFYSGITGTPLEAYIYSGPVYYQKLKHMVQDKMHARARGPKAVLTRQPTQGRSREGGLRLGEMERDCLISYGASMLIMERLMISSDAFEVDVCRTCGRMAYCSWCHFCQSSANVSKISMPYACKLLFQELTSMNVVPKMILENY
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.  Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.  Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit.  Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
What are the official names of this protein?
DNA-directed RNA polymerase III subunit RPC2, RNA polymerase III subunit C2, DNA-directed RNA polymerase III 128 kDa polypeptide, C128.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta chain family.
What are the subcellular locations of this protein?
Nucleus.
Protein: PKN1_HUMAN
Sequence: MASDAVQSEPRSWSLLEQLGLAGADLAAPGVQQQLELERERLRREIRKELKLKEGAENLRRATTDLGRSLGPVELLLRGSSRRLDLLHQQLQELHAHVVLPDPAATHDGPQSPGAGGPTCSATNLSRVAGLEKQLAIELKVKQGAENMIQTYSNGSTKDRKLLLTAQQMLQDSKTKIDIIRMQLRRALQAGQLENQAAPDDTQGSPDLGAVELRIEELRHHFRVEHAVAEGAKNVLRLLSAAKAPDRKAVSEAQEKLTESNQKLGLLREALERRLGELPADHPKGRLLREELAAASSAAFSTRLAGPFPATHYSTLCKPAPLTGTLEVRVVGCRDLPETIPWNPTPSMGGPGTPDSRPPFLSRPARGLYSRSGSLSGRSSLKAEAENTSEVSTVLKLDNTVVGQTSWKPCGPNAWDQSFTLELERARELELAVFWRDQRGLCALKFLKLEDFLDNERHEVQLDMEPQGCLVAEVTFRNPVIERIPRLRRQKKIFSKQQGKAFQRARQMNIDVATWVRLLRRLIPNATGTGTFSPGASPGSEARTTGDISVEKLNLGTDSDSSPQKSSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLSPPRDARPLTAAEQAAFLDFDFVAGGC
What is the function of this protein?
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation.  Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.  Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization.  Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly.  Acts as a key coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C.  Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus.  Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP.  Able to phosphorylate RPS6 in vitro.
What are the official names of this protein?
Serine/threonine-protein kinase N1, Protease-activated kinase 1, PAK-1, Protein kinase C-like 1, Protein kinase C-like PKN, Protein kinase PKN-alpha, Protein-kinase C-related kinase 1, Serine-threonine protein kinase N.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via its interaction with RHOB. Association to the cell membrane is dependent on Ser-377 phosphorylation. Accumulates during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis.
Protein: AMIF_BACC2
Sequence: MGSSGSMVKPISGFLTALIQYPVPVVESRADIDKQIQQIIKTIHSTKSGYPGLELIVFPEYSTQGLNTKKWTTEEFLCTVPGPETDLFAEACKESKVYGVFSIMEKNPGGGEPYNTAVIIDPQGEMILKYRKLNPWVPVEPWKAGDLGLPVCVGPGGSKLAVCICHDGMFPEVAREAAYKGANVLIRISGYSTQVSEQWMLTNRSNAWQNLMYTLSVNLAGYDGVFYYFGEGQVCNFDGTTLVQGHRNPWEIVTAEVYPELADQARLGWGLENNIYNLGSRGYVATPGGVKENPYTFIKDLAEGKYKVPWEDEIKVKDGSIYGYPVKKTIHS
What is the function of this protein?
Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide.
What are the official names of this protein?
Formamidase, Formamide amidohydrolase.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.
Protein: YESK_BACSU
Sequence: MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPEWMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR
What are the official names of this protein?
Uncharacterized protein YesK.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: PARP8_HUMAN
Sequence: MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIATELRKTNDINCCLSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTDDVCVTKSHRTFGRSLSSDPRAEQAMTAIKSHKLLNRPCPAAVKSEECLTLKSHRLLTRSCSGDPRCEHNTNLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNAEGRRLSLTSGLIGILTPSSSSSSQLAPNGAKCIPVRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKSSNTSQSQKKGQQSQFLQSRNLKCIALCEVITSSDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG
What is the function of this protein?
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
What are the official names of this protein?
Protein mono-ADP-ribosyltransferase PARP8, ADP-ribosyltransferase diphtheria toxin-like 16, ARTD16, Poly [ADP-ribose] polymerase 8, PARP-8.
What is the protein family that this protein belongs to?
Belongs to the ARTD/PARP family.
Protein: OBG_RIPO1
Sequence: MQFIDYAEIEVEGGKGGDGIVAFRREKYVPAGGPAGGNGGWGGSVIFVANSNLQTLLDFRYARRFKADDGKRGGPNNCTGANGKDCLVEVPCGTMVYNLETEEILGDLVENGQTLCVAAGGKGGLGNKHFLSNQNRAPDYALPGLEGEHRWLRLELKLLAEVGIIGLPNAGKSTLMASLSAARPKIADYPFTTLVPNLGVVRKPTGDGTVFADIPGLIEGAHEGIGLGHEFLRHIERTRLLLHLVDITSPDPVKDYQIIQQELEAYGRGLSDRPQIIALNKMDAADEETFLLIKNELTHLSSSPIIGISGVSRTGLEDLLQIVWQLLDS
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: B2KA3_SICCD
Sequence: IMGHMVNAIEQVDEFLNLGANAIEFDIDFDKDGIAQITHHGIPCDCGRKCTKKAIFTEYLDNIRQVTTPDDPKFREQLVLLALDLKLQRISSAKAYRAGEDVAKKLLDHYWRRGNSKARAYILLNIPLVEDYEFIRAFKDTLKNEGYESYNDKVGINFTGNEDLDKIRDVLEILGIHKQVWQADGITSCFARGTERLKEALKKRDTPGYNYIDKVYAWTLVRKSIMRRSLRLGVDGVMSNNPDRVIKVLKEKEFADKFRLATYNDNPWEKFRG
What is the function of this protein?
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity).  This toxin acts on sphingomyelin (SM) (By similarity).  It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity).  It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity).  Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).
What are the official names of this protein?
Dermonecrotic toxin SdSicTox-betaIIB1aiii, Phospholipase D, PLD, Sphingomyelin phosphodiesterase D, SMD, SMase D, Sphingomyelinase D.
What is the protein family that this protein belongs to?
Belongs to the arthropod phospholipase D family. Class II subfamily.
What are the subcellular locations of this protein?
Secreted.
Protein: YIHI_VIBCH
Sequence: MSRSKKSRKPGTNSNDQLVVVRTRSESELESRLRKKLKKRKGLKSGSRHSEGSESQVRQAAQKRDPRLGSKKPIPLIVAEPKKLNKQERKLAAEQELAMLEKDAQLNVLLDRLDNGEKLGIGLQKYVDEKLDRIEVLMEQLGLLDDEPEPAPAPQSKPTKKRKTEDDLLSEFEQLDVDKYQD
What is the function of this protein?
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function.  May play a role in ribosome biogenesis.
What are the official names of this protein?
Der GTPase-activating protein YihI.
What is the protein family that this protein belongs to?
Belongs to the YihI family.
Protein: PUR9_SYNWW
Sequence: MKRALISVSNKEGLLDFARGLEKLGYEIISTGGTYNTIKEAGIKVKKVADITGFPEILDGRVKTLHPKIHGGILARRIPEHLQQLQENDIGPIDIVAVNLYPFRETISRPGVSLEEAIENIDIGGPAMVRAAAKNYQDVAVVVKPEFYQALLEALEKPGGISPEFRLKLALEAFSHTAAYDAMISSYLSRVSNSDLNQNLILAGEKVYDLRYGENPHQKASFYRFMTPGLGLPDARQLNGKELSYNNIIDTQAAWELVREFDEPACVIIKHTNPCGTAVAATLEEAFDRAFAADPLSAFGGIIALNRPVDGATAQKAAEPFMEVIIAPAYTPEALESLQAKKNLRVLELPLEVAGGLQIRTVAGGFVVQESDRDKLDMDKVQVVTQKEPTVEQLKELAFARKVVKHIKSNAIVVARDGMTLGVGAGQMNRVGSARIALESAGEKARGAVMASDAFFPFKDTVELAAQYGITAIIQPGGSVRDQESIDECDKHGIAMVFTGIRHFKH
What are the official names of this protein?
Bifunctional purine biosynthesis protein PurH.
What is the protein family that this protein belongs to?
Belongs to the PurH family.
Protein: AIM36_KLULA
Sequence: MFVRAAPRLLKSPVMRRMLSGKMDKAEEPPSFKTILLVGLVGTAIFVKAVDSLEQNKPKNTYTFSEFDTVMSGLRRRVSIFEQDDLNLRCVQTGVATKKLKFPEDAKVIKPSEAIEFFRNKSDDKYYVLLNDLYEKEGKSYMEKLPTGLSVVLIGKYMKEKCQKGDTVYLLDFPDNIKDAIKFENEVSVIDKVIVPNSEGDGQVSKYFKTVDKVETI
What are the official names of this protein?
Altered inheritance of mitochondria protein 36, mitochondrial, Found in mitochondria protein 39.
What is the protein family that this protein belongs to?
Belongs to the AIM36 family.
What are the subcellular locations of this protein?
Mitochondrion membrane; Single-pass membrane protein.
Protein: Y1819_BRUSI
Sequence: MENEPDTICILVDADACPVKAEIYRVAERHNLPVVIVANSFIAIPREAQRVERVVVSGNLDAADDWIAEHSRPGAVVVTADIPLASRALEKGASVIAPNGRIHTQSTIGNTLAARNLMDSLRSAGEVTGGPAPFAPKDRSAFLSALDLAIVRLKRAGFHAS
What are the official names of this protein?
UPF0178 protein BSUIS_A1819.
What is the protein family that this protein belongs to?
Belongs to the UPF0178 family.
Protein: SIRP1_ORYSJ
Sequence: MAEAAITRYWCHECEQAIEEAMVDEIKCPSCGGGFVEEMTDEEIERLTNRQPEPGFSQWNPIEHPGETMDSDDEDNDLGREFEGFIRRHRRASTLRRVLDSIHDDLADDQERDSSILINAFNQALALQGSVLDPDEGQGDQGGSTNDDGLLEEYVLGAGLSLLLQHLAESDPSRNGTPPAKKEAVEALPTVKIEEVVSCSVCLDDLEVGSQAKQMPCEHKFHSSCILPWLELHSSCPVCRFELPSEETKDLNEPSNIGRVEDSHEEVRADGPGNVSESSNRPWAIVPWLNELFSTREAQNAGGVSTDQQSPHTSGTNPNAGHS
What is the function of this protein?
Possesses E3 ubiqutin-protein ligase activity in vitro.  Acts as negative regulator of salinity stress tolerance mediated by the ubiquitin-proteasome degradation pathway.
What are the official names of this protein?
E3 ubiquitin-protein ligase SIRP1, Salt-induced RING finger protein 1, OsSIRP1.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OTC_MYCTO
Sequence: MIRHFLRDDDLSPAEQAEVLELAAELKKDPVSRRPLQGPRGVAVIFDKNSTRTRFSFELGIAQLGGHAVVVDSGSTQLGRDETLQDTAKVLSRYVDAIVWRTFGQERLDAMASVATVPVINALSDEFHPCQVLADLQTIAERKGALRGLRLSYFGDGANNMAHSLLLGGVTAGIHVTVAAPEGFLPDPSVRAAAERRAQDTGASVTVTADAHAAAAGADVLVTDTWTSMGQENDGLDRVKPFRPFQLNSRLLALADSDAIVLHCLPAHRGDEITDAVMDGPASAVWDEAENRLHAQKALLVWLLERS
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis.
What are the official names of this protein?
Ornithine carbamoyltransferase, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: LON8_CAEEL
Sequence: MRNSRFCAILAVISAISVSYVLAQRSQQSVIADLGKLIVDNCPPMLCTGLDCAVVTERNGCQLCACPIGSPSRGCDPMPFILWHDLIVNGCPNVTLNSRDPAQKVHRWFRRVNRFTNTDQCEPYIFPYCPELDFNLWRSPRTKQECELYCYSIDEQRKRGII
What is the function of this protein?
Secreted protein that is involved in larval elongation, early adult growth and male tail development.
What are the official names of this protein?
Protein lon-8.
What are the subcellular locations of this protein?
Secreted.
Protein: FABZ_PSE14
Sequence: MMDIKEIREYLPHRYPFLLVDRVTELDIENKNIRAYKNVSVNEPFFNGHFPEHPIMPGVLIIEAMAQAAGILAFKMLDSKPSDGTLYYFVGSDKLRFRQPVLPGDQLVLEAKFLSSKRQIWKFECKATVDGKAVCSAEIICAERKL
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: OPRI_PSEAE
Sequence: MNNVLKFSALALAAVLATGCSSHSKETEARLTATEDAAARAQARADEAYRKADEALGAAQKAQQTADEANERALRMLEKASRK
What are the official names of this protein?
Major outer membrane lipoprotein, Outer membrane lipoprotein I.
What are the subcellular locations of this protein?
Cell outer membrane; Lipid-anchor.
Protein: TWF1_RAT
Sequence: MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVVGSCSPPSDSWEQDYDPFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYRKYLLSQSSPAPLTAAEEELRQIKISEVQTDVSVDTKHQTLQGVAFPISRDAFQALEKLSKRQLNYVQLEIDIKNETIILANTENTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSPLLDIVERQLQMDVIRKIEIDNGDELTADFLYDEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAEAEATTD
What is the function of this protein?
Actin-binding protein involved in motile and morphological processes.  Inhibits actin polymerization, likely by sequestering G-actin.  By capping the barbed ends of filaments, it also regulates motility.  Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).
What are the official names of this protein?
Twinfilin-1.
What is the protein family that this protein belongs to?
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Cytoplasm, cytoskeleton. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).