PharMolix/UniProtQA huggingface dataset:
Protein: Y1375_METJA
Sequence: MSLCKDSIYILMSNLYSKGMAYLFYFITAFLLGTEAFGILKGLMPIADTLTIFFSSGIPPAIAKFLAEEKEVDINKYIPILYLMILLSVVGFILTPYIKYILGGHYLNLPNILYFAVGLCVVASTVIAFSRGILQGLLKMKYLSLTWIVEYTAKVILVFILTLYLGIFGSLLSISLAYLVGGIFGLYLIYKALKGKFDFKKLIDIKNTTKNIFSNFNLDILRYSIPIALTSSSYRLFGDIDNIVIMSIMGGFWSGIYGYSSLISRGIFMFASAVSIPLLPRISKTKDLSLLKEGIIQNTIFSSIFVIGCLFFPEIPLIAFFKTANPEGILCLRILAISSLFMSYYTLISSALQGLGYAKISFYIILFGLVLNIILNLILVNAYGIVGGSLATLITSISVFLIGVFAILRIKKHII
What are the official names of this protein?
Uncharacterized membrane protein MJ1375.
What is the protein family that this protein belongs to?
Belongs to the polysaccharide synthase family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: CPSD_STRA3
Sequence: MTRLEIVDSKLRQAKKTEEYFNAIRTNIQFSGKENKILAITSVREGEGKSTTSTSLALSLAQAGFKTLLIDADTRNSVMSGTFKATGTIKGLTNYLSGNADLGDIICETNVPRLMVVPSGKVPPNPTALLQNAYFNKMIEAIKNIFDYIIIDTPPIGLVVDAAIIANACDGFILVTQAGRIKRNYVEKAKEQMEQSGSKFLGIILNKVNESVATYGDYGDYGNYGKRDRKRK
What is the function of this protein?
Involved in the regulation of capsular polysaccharide biosynthesis.  Autophosphorylation of CpsD attenuates its activity and reduces the level of encapsulation.  May be part of a complex that directs the coordinated polymerization and export to the cell surface of the capsular polysaccharide (By similarity).
What are the official names of this protein?
Tyrosine-protein kinase CpsD.
What is the protein family that this protein belongs to?
Belongs to the CpsD/CapB family.
Protein: LOVHK_BRUO2
Sequence: MAIDLRPFIPFGRGALSQATDPFRAAVEFTLMPMLITNPHLPDNPIVFANPAFLKLTGYEADEVMGRNCRFLQGHGTDPAHVCAIKSAIAAEKPIDIDIINYKKSGEAFWNRLHISPVHNANGRLQHFVSSQLDVTLELSRLVELEKERKTLSIETARSKDQLDYIVEVANIGFWTREFYSGKMTCSAECRRIYGFTPDEPVHFDTILDLVVLEDRMTVVQKAHQAVTGEPYSIEYRIVTRLGETRWLETRAKALTGENPLVLGIVQDVTERKKAEANKALVSREIAHRFKNSMAMVQSIANQTLRNTYDPEQANRLFSERLRALSQAHDMLLKENWAGATIQQICATALAPFNSTFANRIHMSGPHLLVSDRVTVALSLAFYELATNAVKYGALSNEKGVINITWAIMEDKGEKKFHMRWAESRGPEVMQPARRGFGQRLLHSVLAEELKAKCDVEFAASGLLIDVLAPITPEVFPGMGHNVPEQRIA
What is the function of this protein?
Photosensitive kinase that is involved in increased bacterial virulence upon exposure to light.  Once ejected from an infected animal host, sunlight acts as an environmental signal that increases the virulence of the bacterium, preparing it for infection of the next host.  This photoreceptor protein is directly related to the bacterium's survival and replication within host macrophages (By similarity).
What are the official names of this protein?
Blue-light-activated histidine kinase.
Protein: MURI_STRGC
Sequence: MDNRPIGFLDSGVGGLTVVRELMRQLPHEEVIYIGDSARAPYGPRPAEQIRDYTWQLVNFLLTKDVKMIVIACNTATAVVWEEIKEKLDIPVLGVILPGASAAIKSTHSGKIGVIGTPMTVTSDIYRKKIEALSPEMEVSSLACPKFVPLVESNELTSSVTKKVVYETLLPLAGKVDTLVLGCTHYPLLRSIIQNVMGPDVKLIDSGAECVRDISVLLNYFEINRSREEQTLRHRFYTTASAKSFAEIAEHWLGQKVSVEHIDL
What is the function of this protein?
Provides the (R)-glutamate required for cell wall biosynthesis.
What are the official names of this protein?
Glutamate racemase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/glutamate racemases family.
Protein: CBIA_STRSV
Sequence: MKQFMLAGVSSGVGKTTVTLGILKALADRGYQVQPYKIGPDYIDTAYHSRITKRPSRNVDSFMIPDDQSLAWSYYKWHGDADVAVVEGVMGLFDGLGTDKDCASSASVAKKLGIPVVLIIDGKATSTSAAAMVHGFATFDPDLDIAGVIINRVASQTHFELIKGAIERYTDVEVLGYLPKNATAELPSRHLGLIPDVEMDDLDRRFEDLGAATAKHINLDRLLEKAELPDKRMTNPFRISNDQPLTLAYALDDAFHFYYEDNLDFLRELNVQLVPFSPLKDKELPAADAYYFGGGFPEVYAQELMANADFRASVKKAHEQGRPIYAECGGLMYLGELLEVEGQVYEMVGIFKGKSLMTPGLKSFGYCQAETQVDSLFGPKGTAVRGHEFHHSVFETEEDTVLKLEKVRDGQVVAAWTGGYQKGRTFASYLHVHFYQDEQLLANWLDYIKEAN
What is the function of this protein?
Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
What are the official names of this protein?
Cobyrinate a,c-diamide synthase, Cobyrinic acid a,c-diamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the CobB/CbiA family.
Protein: PFLA_ECOLI
Sequence: MSVIGRIHSFESCGTVDGPGIRFITFFQGCLMRCLYCHNRDTWDTHGGKEVTVEDLMKEVVTYRHFMNASGGGVTASGGEAILQAEFVRDWFRACKKEGIHTCLDTNGFVRRYDPVIDELLEVTDLVMLDLKQMNDEIHQNLVGVSNHRTLEFAKYLANKNVKVWIRYVVVPGWSDDDDSAHRLGEFTRDMGNVEKIELLPYHELGKHKWVAMGEEYKLDGVKPPKKETMERVKGILEQYGHKVMF
What is the function of this protein?
Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
What are the official names of this protein?
Pyruvate formate-lyase 1-activating enzyme, Formate-C-acetyltransferase-activating enzyme 1, PFL-activating enzyme 1.
What is the protein family that this protein belongs to?
Belongs to the organic radical-activating enzymes family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SSRA_CANLF
Sequence: MRVLPRLLLLLLLAFPAAVLLRGGPGGSLVAAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLAEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTIIEREDGLDGETIFMYMFLAGLGLLVVVGLHQLLESRKRKRPIQKVEMGTSSQNDVDMSWIPQETLNQINKASPRRLPRKRAQKRSVGSDE
What is the function of this protein?
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.  May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
What are the official names of this protein?
Translocon-associated protein subunit alpha, TRAP-alpha, PGP35, Signal sequence receptor subunit alpha, SSR-alpha.
What is the protein family that this protein belongs to?
Belongs to the TRAP-alpha family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein: Y1462_METJA
Sequence: MMIYGILLNIPEKHATKYEDLIRRIIGEGIARGDILSFTEARYKGDVAFVMLARSRRAAEKVYQQLKEHPIHVKVIEIEGKGD
What are the official names of this protein?
Uncharacterized protein MJ1462.
Protein: FNTB_BOVIN
Sequence: MASPSSFTYCCPPSSSPIWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQMVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDVINREKLLQYLYSLKQPDGSFLMHDGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSRWMFHQQALQEYILMCCQCPTGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATMHFLQKPVPGFEEHEDEASAEPATD
What is the function of this protein?
Essential subunit of the farnesyltransferase complex.  Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
What are the official names of this protein?
Protein farnesyltransferase subunit beta, FTase-beta, CAAX farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the protein prenyltransferase subunit beta family.
Protein: NFUA_ECOK1
Sequence: MIRISDAAQAHFAKLLANQEEGTQIRVFVINPGTPNAECGVSYCPPDAVEATDTALKFDLLTAYVDELSAPYLEDAEIDFVTDQLGSQLTLKAPNAKMRKVADDAPLMERVEYMLQSQINPQLAGHGGRVSLMEITEDGYAILQFGGGCNGCSMVDVTLKEGIEKQLLNEFPELKGVRDLTEHQRGEHSYY
What is the function of this protein?
Involved in iron-sulfur cluster biogenesis.  Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins.  Could also act as a scaffold/chaperone for damaged Fe/S proteins.
What are the official names of this protein?
Fe/S biogenesis protein NfuA.
What is the protein family that this protein belongs to?
Belongs to the NfuA family.
Protein: CCAP_PERAM
Sequence: MQMYHVVLGCSLAILLVILDIPQASCDDVVIQKRQVDPAEMDRLLDPKRKRPFCNAFTGCGKKRSDESMGTLVEMNSEPAVDDLSRQILSEVKLWEAIQEARVELLRRRQEQLQQQSNQFGAGMDRPLPLPIAGYRRKRFADPESQAPAPHSNLPRATSQLQEEITKPWSR
What is the function of this protein?
Cardioregulatory neurohormone that increases heart beat rate during adult wing inflation; has no effect on beat amplitude.  The effect of CCAP is both ino- and chronotropic (By similarity).
What are the official names of this protein?
Cardioactive peptide, Cardioacceleratory peptide 2a, Crustacean cardioactive peptide, CCAP.
What are the subcellular locations of this protein?
Secreted.
Protein: ATPA_NOVAD
Sequence: MEIRAAEISKVIKDQIASFGTEAQVSEVGSVLSVGDGIARIHGLDKVQAGEMVEFSNGVKGMALNLEADNVGVVIFGSDSEIKEGDVVKRTGTIVDVPVGKGLLGRVVDALGNPIDGKGPIVDATRQRVEVKAPGIIPRKSVHEPVQTGLKAIDALVPVGRGQRELIIGDRQTGKTAVAIDTFINQKAVNAGTDEGKKLYCIYVAVGQKRSTVAQIVRQLEENGAMEYSIVVAATASEPAPLQYLAPYTGATMGEFFRDNGMHAVIVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDENGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETGLFYQGIRPAINVGLSVSRVGSSAQTKAMKKVAGSIKLELAQYREMAAFAQFGSDLDASTQKLLNRGARLTELLKQPQFSPLGFEEQTCVIFAGTQGYLDAVPVNRVTEYEAELLSFLRSQHADLLGLIRDTKDLGDEAKGKLVAALDAFAKQFA
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The alpha chain is a regulatory subunit.
What are the official names of this protein?
ATP synthase subunit alpha, ATP synthase F1 sector subunit alpha, F-ATPase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SUFS_SALAR
Sequence: MTFPVEKVRADFPILQREVNGLPLAYLDSAASAQKPNQVIDAESAFYRHGYAAVHRGIHTLSAQATESMENVRKQASRFINARSAEELIFVRGTTEGINLVANSWGAENIRAGDNIIISEMEHHANIVPWQMLCERKGAELRVIPLNPDGTLRLEVLATLFDDRTRLLAITHVSNVLGTENPLPEMIAQARQHGAKVLVDGAQAVMHHAVDVQALDCDFYVFSGHKLYGPTGIGILYVKEALLQEMPPWEGGGSMIATVSLAQGTTWAKAPWRFEAGTPNTGGIIGLGAAIDYVASLGLDKIGDYEQMLMHYALEQLAQVPDIRLYGPAQRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAWYGVPAMCRASLAMYNTYEEVDRLVAGLTRIYRLLG
What is the function of this protein?
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules.  Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation.  Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine.  Selenocysteine lyase activity is however unsure in vivo.
What are the official names of this protein?
Cysteine desulfurase, Selenocysteine beta-lyase, SCL, Selenocysteine lyase, Selenocysteine reductase.
What is the protein family that this protein belongs to?
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PCKA_ECOSM
Sequence: MRVNNGLTPQELEAYGISDVHDIVYNPSYDLLYQEELDPSLTGYERGVLTNLGAVAVDTGIFTGRSPKDKYIVRDDTTRDTFWWADKGKGKNDNKPLSPETWQHLKGLVTKQLSGKRLFVVDAFCGANPDTRLSVRFITEVAWQAHFVKNMFIRPSDEELAGFKPDFIVMNGAKCTNPQWKEQGLNSENFVAFNLTERMQLIGGTWYGGEMKKGMFSMMNYLLPLKGIASMHCSANVGEKGDVAVFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDDGVFNFEGGCYAKTIKLSKEAEPEIYNAIRRDALLENVTVREDGSIDFDDGSKTENTRVSYPIYHIENIVKPVSKAGHATKVIFLTADAFGVLPPVSRLTADQTQYHFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTQYAEVLVKRMQAAGAQAYLVNTGWNGTGKRISIKDTRAIIDAILNGSLDNAETFTLPMFNLAIPTELPGVDTKILDPRNTYASPEQWQEKAETLAKLFIDNFDKYTDTPAGAALVAAGPKL
What is the function of this protein?
Involved in the gluconeogenesis.  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
What are the official names of this protein?
Phosphoenolpyruvate carboxykinase (ATP), PCK, PEP carboxykinase, PEPCK.
What is the protein family that this protein belongs to?
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: URE1_KLEP7
Sequence: MSNISRQAYADMFGPTVGDKVRLADTELWIEVEDDLTTYGEEVKFGGGKVIRDGMGQGQMLAADCVDLVLTNALIVDHWGIVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVTAGGIDTHIHWICPQQAEEALVSGVTTMVGGGTGPAAGTHATTCTPGPWYISRMLQAADSLPVNIGLLGKGNVSQPDALREQVAAGVIGLKIHEDWGATPAAIDCALTVADEMDIQVALHSDTLNESGFVEDTLAAIGGRTIHTFHTEGAGGGHAPDIITACAHPNILPSSTNPTLPYTLNTIDEHLDMLMVCHHLDPDIAEDVAFAESRIRRETIAAEDVLHDLGAFSLTSSDSQAMGRVGEVILRTWQVAHRMKVQRGALAEETGDNDNFRVKRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSPAFFGVKPATVIKGGMIAIAPMGDINASIPTPQPVHYRPMFGALGSARHHCRLTFLSQAAAANGVAERLNLRSAIAVVKGCRTVQKADMVHNSLQPNITVDAQTYEVRVDGELITSEPADVLPMAQRYFLF
What are the official names of this protein?
Urease subunit alpha, Urea amidohydrolase subunit alpha.
What is the protein family that this protein belongs to?
Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSTB_RHOPB
Sequence: MTEISITTSVPDAGAPPSVVGGQVERAKVSVRDLNFYYGDNHALKAINLNLIANRVTAFIGPSGCGKSTLLRVFNRMYDLYPGQRATGQVMLDSQNVLDAKLDLNLLRARVGMVFQKPTPFPMTIYENIAFGVRLYEKISKSEMDNRVERALRGGALWNEVKDQLGASGLSLSGGQQQRLCIARTIAVRPEVILFDEPCSALDPISTAKIEELIDELKEDYTIAIVTHNMQQAARVSDSTAFMYLGELIEFGETNKIFTSPTDRRTQDYITGRFG
What is the function of this protein?
Part of the ABC transporter complex PstSACB involved in phosphate import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphate import ATP-binding protein PstB, ABC phosphate transporter, Phosphate-transporting ATPase.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: ACNA_MYCS2
Sequence: MSSENTGKSSLNSFGARDTLTVGDQSYEIYRLNAVPGTEKLPYSLKVLAENLLRTEDGANITKDHIEAIANWDPNAEPSIEIQFTPARVIMQDFTGVPCIVDLATMREAVAALGGDPNKVNPLAPAELVIDHSVILDVFGNASAFERNVELEYERNAERYQFLRWGQGAFDDFKVVPPGTGIVHQVNIEYLARTVMVRDGVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLIPRVVGFKLSGEIKPGVTATDVVLTVTDMLRRHGVVGKFVEFYGKGVAEVPLANRATLGNMSPEFGSTAAIFPIDEETINYLRLTGRTDEQLALVEAYAKAQGMWHDPEREPVFSEYLELDLSTVVPSISGPKRPQDRIELTDAKNAFRKDIHNYVEQNHPTPETKLDEAVEESFPASDPVSLSFADDGAPDMRPSAANGATGRPTNPVLVHSEERGDFVLDHGAVVVAGITSCTNTSNPSVMLGAALLAKKAVEKGLTTKPWVKTNMAPGSQVVTDYYNKAGLWPYLEKLGYYLGGYGCTTCIGNTGPLPEEISKAINDNDLAVTAVLSGNRNFEGRISPDVKMNYLASPPLVIAYGIAGTMDFDFESDPLGQDSEGNDVFLRDIWPSAAEIEETIASSINREMFTESYADVFKGDDRWRSLPTPEGDTFEWDPASTYVRKAPYFDGMPAEPEPVSDIKGARVLALLGDSVTTDHISPAGAIKPGTPAAQYLDANGVERKDYNSLGSRRGNHEVMIRGTFANIRLRNQLLDDVSGGYTRDFTQPGGPQAFIYDASENYKKAGIPLVVLGGKEYGSGSSRDWAAKGTVLLGVKAVITESFERIHRSNLIGMGVIPLQFPAGESAASLKLDGTETYDIEGIEELNSGKTPKTVHVTATKEDGSKVEFDAVVRIDTPGEADYYRNGGILQYVLRNMLKSSK
What is the function of this protein?
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route).  Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate.  The apo form of AcnA functions as a RNA-binding regulatory protein.  Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate.
What are the official names of this protein?
Aconitate hydratase A, ACN, Aconitase, (2R,3S)-2-methylisocitrate dehydratase, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase, Iron-responsive protein-like, IRP-like, Probable 2-methyl-cis-aconitate hydratase, RNA-binding protein.
What is the protein family that this protein belongs to?
Belongs to the aconitase/IPM isomerase family.
Protein: RL1_DEHM1
Sequence: MVTRGKKYQDAIKLLDQSLAYAPAEAIDVAKKMAAAKFDETVEMHLKMGLDPKNATQQLRGVAVLPHGLGKTVRVLVFAQGEAEKAAQAAGADVYGGDELIKKVEAGFLDFDVAISTPDMMSKVGKLGKVLGRRGLMPNPKSGTVVPAEDFKQVIEEARKGRVEFKLDRSGIVHIILGKASFEGQALLENMTSVVDAIIRSKPTGAKGQYIKSAYLATTMGPGVKMDLRAVSAMGGA
What is the function of this protein?
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
What are the official names of this protein?
50S ribosomal protein L1.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL1 family.
Protein: AFT11_ALTAL
Sequence: MVFTAPCWVPPLPSDLPDSTTLEEFIFCQVKDSQTRSELDRSILICGTQGREYTVQESMERTGRLAQGLSAWLNWPQKSPGKDWKVAAIFNVNCVDFFSISHAIHRLGGTISAINASSTADELEAQLRLSNAQAIFTCNTLLKIAMKASQRVGIPLANIFLTDAPGSYRPDDVYPFQEIDNIVRTAKSSLPLLQLGRGQGASTPAYICFSSGTSGAQKPVLLSHQGIIANIVQINTFEKFRQKGPNISLCILPLAHSYGLVCVAYSALYRGDRLAVLPSSGVEDLLSIVEKLKINTLYLVPTLVSRILSGGKAGRHDLRCVKEVYTGGAPLHPMLGEHILRHHPTWKIKQCYGATEAGTAVSVTSDCDLWPGSVGCLLPGVQAKIVKSDGSETTKHDESGELWVSSPSLAIGYLSNPLATKTTFTVDNTGKTWLRTGDEVKICLSPNGNEHLFIVDRIKDIIKVKGFQVAPVELEQLLLSNDFVEEVAVTSRQDEGEEERPQAFVVRSQVGLEEPQGAVAESLHALVKARKARYKWLHPHVIFVDSLPKTTSGKIMRRALRNMSPANSEVNSRLSSKI
What is the function of this protein?
Acyl-CoA ligase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AF-toxins responsible for Alternaria black spot of strawberry disease by the strawberry pathotype (PubMed:12019223).  AF-toxin I and III are valine derivatives of 2,3-dyhydroxy-isovaleric acid and 2-hydroxy-isovaleric acid respectively, while AF II is an isoleucine derivative of 2-hydroxy-valeric acid (PubMed:15066029, Ref. 3, PubMed:22846083).  These derivatives are bound to a 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) moiety (PubMed:15066029, Ref. 3, PubMed:22846083).  On cellular level, AF-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).  The aldo-keto reductase AFTS1 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV) by reduction of its ketone to an alcohol (PubMed:15066029).  The acyl-CoA ligase AFT1, the hydrolase AFT2 and the enoyl-CoA hydratases AFT3 and AFT6, but also the polyketide synthase AFT9, the acyl-CoA dehydrogenase AFT10, the cytochrome P450 monooxygenase AFT11 and the oxidoreductase AFT12 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common EDA structural moiety (PubMed:12019223, Ref. 3, PubMed:18986255).  The exact role of each enzyme, and of additional enzymes identified within the AF-toxin clusters have still to be determined (PubMed:12019223, Ref. 3, PubMed:18986255).
What are the official names of this protein?
Acyl-CoA ligase AFT1-1, AF-toxin biosynthesis protein 1-1.
What is the protein family that this protein belongs to?
Belongs to the ATP-dependent AMP-binding enzyme family.
What are the subcellular locations of this protein?
Peroxisome. Note=The peroxisomal location requires the C-terminal tripeptide peroxisomal targeting signal.
Protein: 1A112_ARATH
Sequence: MRLIVPLRGVIQGRGGLFVGSLIPCCLFYFLQLYLKRRRPPPSDPTDLPRTFSRTNLFSRGNSIGRVRVSSRAVPVAKPSDSPYYIGLERVKTDPYDRITNTDGIIQLGLAESTLCFDLLQRWMSENLMESMMQSDDGEFDISSIAMYKPFEGLLELRVAFADFMSRIMGGNVSFDPSNMVITAGGTPAIEVLAFCLADHGNAFLIPTPYYPGFDRDIKFRTGVELIPVHCRSSDNFTVTVSALEQALNQARKRGSKVSGILFSNPSNPVGNILSRETLCDILRFAQEKNIHVISDEIFAGSVYGDKEFVSMAEIAGSGEFDKTRVHIIYGLSKDLSIPGFRAGVIYSFHEDVVNAAKKLMRFSSVPVLVQRILISLLSDVRFIEGYMAAHRQRIRDKHIRFVEGLKQLGIPCAESGGGLYCWVDMSSLLTSYSEKGELELFEKLLTVAKINATPGTACYCIEPGWFRCCFTALADEDIPVIMERIRQLAESFRS
What is the function of this protein?
Probable aminotransferase.  Does not have 1-aminocyclopropane-1-carboxylate synthase (ACS) activity, suggesting that it is not involved in ethylene biosynthesis.
What are the official names of this protein?
Probable aminotransferase ACS12.
What is the protein family that this protein belongs to?
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Protein: CH60_ACIAD
Sequence: MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEITLKDKFENMGAQLVREVSSKTNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVRAVVENIRATAKPADDFKAIEQVGSISANSDETVGKLIAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELITTLEAVAKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQASLQDLGTAHKITVSKENTVIVDGAGDANAIAERVQQIRAQIEESTSEYDKEKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALVRAVNSLDGLTGANDDQTVGINILRRAIEAPLRQIVSNAGDEPSVVINAVKAGEGNYGYNAATGVYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTEAMITDIPEDKPAMPDMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENGB_PASMU
Sequence: MSDIKLNYHKTHFLTSAPDIRALPEDSGIEIAFAGRSNAGKSTALNALTNQKSLARTSKTPGRTQLINLFEVEPQCRLVDLPGYGYAAVPEQMKIQWQKALGEYLQKRQCLAGVVILMDIRHPLKDLDQQMIEWAVASELPVLLLLTKADKLSQSARSKQVKMVREAILPFQGDVQVEAFSALNKTGIDRLAAKLDSWFAPVLSE
What is the function of this protein?
Necessary for normal cell division and for the maintenance of normal septation.
What are the official names of this protein?
Probable GTP-binding protein EngB.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
Protein: RL35_MYCAP
Sequence: MPKMKTKSALKKRIKVTATGKVIREQAYRSHLAQNKTTKQKRQSRKSAQMHSSDLKRFKALI
What are the official names of this protein?
50S ribosomal protein L35.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL35 family.
Protein: ORN_MYCBP
Sequence: MQDELVWIDCEMTGLDLGSDKLIEIAALVTDADLNILGDGVDVVMHADDAALSGMIDVVAEMHSRSGLIDEVKASTVDLATAEAMVLDYINEHVKQPKTAPLAGNSIATDRAFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPPKGLTHRALADIHESIRELRFYRRTAFVPQPGPSTSEIAAVVAELSDGAGAQEETDSAEAPQSG
What is the function of this protein?
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
What are the official names of this protein?
Oligoribonuclease.
What is the protein family that this protein belongs to?
Belongs to the oligoribonuclease family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS8_RALSO
Sequence: MSMSDPIADMLTRIRNAQAVEKASVVMPSSKLKVAIAKVLKDEGYIDDFAVTEQGGKASLTIGLKYYAGRPVIERLERVSKPGLRVYKGRNEIPQVMNGLGVAIISTPQGLMTDRRARATGVGGEVICYVA
What is the function of this protein?
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
What are the official names of this protein?
30S ribosomal protein S8.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS8 family.
Protein: MEND_PROA2
Sequence: MNHKEITTLWSWIIVEELVRNSICFFCISPGSRSTPLTVAASRHQKTTCKIFPDERAAAFFALGYARATGRPAVLICTSGTAAANYFPAVVEASMGHQPMLVLSADRPFELRETGANQTIRQSGIYGSYSRWSFQLPEPSTDTPPEAILSAIDYAVSTCTANPSGPVHLNIAFREPLEPVPLNENSPWLSSLGKWNSSRAPWSRTLQRQSSPESASVKEVARLLASAENPLIIAGHLDRPADAQAVLNLSKSLNIALYADISSQLRLHKETVALQQAWLSDKYVEQHRADLVLHFGGSLVGKKPGQAMKTWRPDHTIVIKNHPDRYAPDHTVTMSIEASVKAFAEALAKTSQPQGKKANPIDEIEQEIERFTRPDSPVTEISAARIVSRLIDPGHGLFLANSMPVRDMDMYATRSGGTIIPTAMNRGASGIDGIISSAAGFASGLERPVTLLIGDISFLHDMNALCLLRSMTVPLTIVVINNNGGGIFSFLPISDQPDVFEKNFGTPQEFNIAAAATAFSIEYQCPPSNAAFSESYMAARSSAETSIIEIRSRRDENLALHRKLNQSLIDRLDRQQSC
What is the function of this protein?
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
What are the official names of this protein?
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, SEPHCHC synthase, Menaquinone biosynthesis protein MenD.
What is the protein family that this protein belongs to?
Belongs to the TPP enzyme family. MenD subfamily.