PharMolix/UniProtQA huggingface dataset:
Protein: CSK22_BOVIN
Sequence: MPGPAARSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
What is the function of this protein?
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.  Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection.  May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response.  During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage.  Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation.  Can also negatively regulate apoptosis.  Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3.  Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8.  Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV.  Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB.  Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function.  Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1.  Acts as an ectokinase that phosphorylates several extracellular proteins.
What are the official names of this protein?
Casein kinase II subunit alpha', CK II alpha'.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Interaction with SIRT6 prevents translocation into the nucleus.
Protein: ERA_DESVM
Sequence: MTKTEHRCGWVALLGPPNAGKSTLLNSALGHKVAIVTPRAQTTRNQIVGILSEPDAQVIFMDTPGIHQQRGRMNKILLQTAWQSMHSADVILVMLDADLYIKKPDFLENDVKPLMDAVAAEERPVIVAVNKVDLFRDKSKMLPLFIELQKLWPKAEVFPVSALKRDGLPELVKLVKSKLPVAPALYPEDQLSTLPVRFMAAEIVREKLFLALRQELPYSVAVEIEKWDEEEGRDLVTIHAVIYVGRPSHKSMVIGKAGATIKDIGTKARVDIQDLLEKKVHLELWVKVREGWTEDVGFLRSLGLADE
What is the function of this protein?
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange.  Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
What are the official names of this protein?
GTPase Era.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
What are the subcellular locations of this protein?
Cytoplasm. Cell inner membrane; Peripheral membrane protein.
Protein: LPE1_MAIZE
Sequence: MPPVKAEDLVVHAVKEQFAGLDYCITSPPPWITTVLVGFQHYLVMLGTTVLIATIIVPLMGGGHAEKAIVIQTILFLSGINTLLQVHFGTRLPAVMSGSYTYIYPAVAIILSPRYALLIDPLERFVFTMRSLQGALIIAGVFQAVVGFFGIWRVFIRFLSPLAAVPFVTLTGLGLFFFAFPGVTKCIEVGLPALVLLVIFAEYASHLFAKGSFVFSRCAVLVTVVIIWIYAEILTAAGAYNERGPVTQFSCRADRSGIIQGSPWVRFPYPFQWGYPIFCFQDCFAMLAASFASLIESTGTLIAVSRYSGATFCPPSVFSRGIGWEGISIILDGMCGTLTGTAASVENAGLLAVTRVGSRRVIKISALFMIFFSLFAKFGAVLASIPLPIFAALYCVLFAYSAGAGFSLLQYCNLNSLRTKFILSISLFLGLSIPQYFRVYEMFFGFGPVHTHSVAFNVMVNVIFSSPATVAAILAYLLDCTHLYWEASVKKDRGWFWWEKFKSYKYDGRSEEFYRLPYGLSRYFPSL
What is the function of this protein?
High affinity uric acid-xanthine transporter in A. nidulans.  Binds, but cannot transport ascorbic acid.
What are the official names of this protein?
Nucleobase-ascorbate transporter LPE1, Leaf permease protein 1.
What is the protein family that this protein belongs to?
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
What are the subcellular locations of this protein?
Membrane; Multi-pass membrane protein.
Protein: CLCC1_HUMAN
Sequence: MLCSLLLCECLLLVAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG
What is the function of this protein?
Seems to act as a chloride ion channel (PubMed:30157172).  Plays a role in retina development (PubMed:30157172).
What are the official names of this protein?
Chloride channel CLIC-like protein 1, Mid-1-related chloride channel protein 1.
What is the protein family that this protein belongs to?
Belongs to the chloride channel MCLC family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Nucleus membrane; Multi- pass membrane protein. Note=Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes.
Protein: DRB3_HUMAN
Sequence: MVCLKLPGGSSLAALTVTLMVLSSRLAFAGDTRPRFLELRKSECHFFNGTERVRYLDRYFHNQEEFLRFDSDVGEYRAVTELGRPVAESWNSQKDLLEQKRGRVDNYCRHNYGVGESFTVQRRVHPQVTVYPAKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSALTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
What is the function of this protein?
ALLELE DRB3*03:01: Presents a series of conserved peptides derived from the M.  tuberculosis PPE family of proteins, in particular PPE29 and PPE33, known to be highly immunogenic (PubMed:32341563).  Presents immunogenic epitopes derived from C.  tetani neurotoxin tetX, playing a role in immune recognition and long-term protection (PubMed:2788702).  Displays immunodominant viral peptides from HCV non-structural protein NS2, as part of a broad range T-helper response to resolve infection (PubMed:16148104).
What are the official names of this protein?
HLA class II histocompatibility antigen, DR beta 3 chain, MHC class II antigen DRB3.
What is the protein family that this protein belongs to?
Belongs to the MHC class II family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane; Single- pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Autolysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173). Component of immunological synapses at the interface between T cell and APC.
Protein: CCD82_MOUSE
Sequence: MVHVRRHETRKNSKTQKPEQKSRVDWHRTKRSISQLFDSDEELDSNEELDSDEEHDSGESIDSDEELDISKKSDINELPEKETELKLIKVESQGSNSKHLTNTSNSSADEEQLKETKHNDLPDDEAHPGQAENHHNRHTGQILEEDMEDEYIKPGKRKRLSSVMYDSDESDDSDILIRKASAKHPRRVVEDECSSLEMEQETPEKSSAARKREYHQKLQELSERSRQRRRRNSGRNFEDSEKDSCSGTGEEDEDEDEDDYRYDEDGDDYMIDDFVVRNEEGDDENSNQQGENLTTSQLKLVKQNSLYSFSDHYTHFERVVKALLINAFDESFLETLYAGTRKKSYAKDMLTSLHYLDNRFIQPRLESLVSRSRWKEQYKERVESYSNLNILSKSPENCVCQACGLHRHCKFSVHLSGKLYNIRTMETDDFMSHDKQVFTVGRICVERTRIYHKLKHFKFKLYQDCCLIAKPEEVGDEQVKDTVKRVFNHSKERGWIRKKYDQLQNFLNSADYFQDEKF
What are the official names of this protein?
Coiled-coil domain-containing protein 82.
Protein: OBG_SYNWW
Sequence: MFVDQARIFVKGGDGGNGIVAFRREKYVPMGGPSGGDGGRGANVILVADEGLKTLMDFKYRRHFKAERGAHGQGKNMHGAWGQDLRVKVPVGTVIKDDESGEVLADLLLQGQEAVVAKGGRGGRGNARFSSAINKAPSFSENGEPGEEKWIRLELKLLADVGLVGFPNAGKSTLISRVSAARPKIADYPFTTLVPNLGVVMTKERDTFVLADIPGLIEGAHQGLGLGHEFLRHIERTRVILFILDAAQTEGRDVVEDYRILYRELELHNPDLLKRPQLIVANKMDIPDARDNARRLESELGKTVHCISAVTGQGVEELMGKTYALLQAAPQEIPSGEEPVVRRFEEELPFKIDKVDGVFEVSGPRIEKLVVMTNFNSDEGLQRFQRTVIKMGLEEALKEHGIKEGDSVRIKDFEFEFTE
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: YUGJ_BACSU
Sequence: MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKRSGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVIDCTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEKYGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCESLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAVYDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSAFWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL
What are the official names of this protein?
Probable NADH-dependent butanol dehydrogenase 1.
What is the protein family that this protein belongs to?
Belongs to the iron-containing alcohol dehydrogenase family.
Protein: VAPC4_MYCTU
Sequence: MNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAWALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI
What is the function of this protein?
Toxic component of a type II toxin-antitoxin (TA) system.  Probably exerts its toxic effect by binding to mRNA, inhibiting translation.  Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis.  Upon expression in situ, in M. smegmatis or E. coli inhibits cell growth and colony formation; in at least E. coli also causes increased levels of cellular RNA.  Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4.
What are the official names of this protein?
Ribonuclease VapC4, RNase VapC4, Toxin VapC4, VapC-mt4.
What is the protein family that this protein belongs to?
Belongs to the PINc/VapC protein family.
What are the subcellular locations of this protein?
Secreted. Note=Following 6 weeks of nutrient starvation.
Protein: RF1_SALEP
Sequence: MKPSIVAKLEALHERHEEVQALLGDAGIIADQDRFRALSREYAQLSDVSRCFTDWQQVQDDIETAQMMLDDPEMREMAQEELREAKEKSEQLEQQLQVLLLPKDPDDERNAFLEVRAGTGGDEAALFAGDLFRMYSRYAEARRWRVEIMSMSEGEHGGYKEIIAKISGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPEAELPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIHAAETAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDETMEGKLDMLIEPIVQEHQADLLAALSEQE
What is the function of this protein?
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
What are the official names of this protein?
Peptide chain release factor 1, RF-1.
What is the protein family that this protein belongs to?
Belongs to the prokaryotic/mitochondrial release factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PTH_PSELT
Sequence: MKVIVGLGNPGPRYAFNRHNVGFMFVDRFKEFKKCSTWQHRDRYTFSQCKDIFLVKPNTFMNLSGIAVIKCQRDFHVTTTDIIVVYDDVDLPCGRLRIKAQGGSGGHRGLQSIIDYIGTNEFVRLRIGIGPKPENIDLADYVLEDFTEEELRLIDKVLDKAVEAVDVMLNEGLSKAMSVFNSYEVVL
What is the function of this protein?
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
What are the official names of this protein?
Peptidyl-tRNA hydrolase, PTH.
What is the protein family that this protein belongs to?
Belongs to the PTH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ENO_FRASN
Sequence: MPSIEAVGAREILDSRGNPTVEVEVVLEDGTLGRAAVPSGASTGAFEAVELRDGGDRYGGKGVTKAVEAVIGRIGPAIMELEATEQRLLDATLIDLDGTPGKSALGANALLGVSLAVAKAAAASSGLPLFRYLGGPSAHLLPVPMMNILNGGAHADTNVDIQEFMIAPIGAGTFAESLRWGAEIYQALKSVLKGRGLATGVGDEGGFAPSLPTNREALDLIAEAIDKAGFGLGDDIALALDVASTEFFADGSYTFEGSGRSAEQMIDYYADLVDSYPIVSIEDPLAEDDWAGWTSITTRLGARVQLVGDDLFVTNPERLARGIAEGAANALLVKVNQIGTLTETLDAVNLAHRSGYRCMMSHRSGETEDTTIADLAVAVDCGQIKTGAPARSERVAKYNQLLRIEEELDDAARYAGAGAFPRRTTTG
What is the function of this protein?
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.  It is essential for the degradation of carbohydrates via glycolysis.
What are the official names of this protein?
Enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase.
What is the protein family that this protein belongs to?
Belongs to the enolase family.
What are the subcellular locations of this protein?
Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Protein: HRCA_CHLFF
Sequence: MSRSWISKRESKILYILLTTTELYLKTGQPVGSKTLKEYECSNLSTATIRNYFSELESEGFLKKNHISGGRIPTDLAFRYYVDHCADFSQSELPESTTRLLNQLPEESQNIVKDLQKALEILGEALQLPTCFSSPRFENDSITNIQISLVDEQRVVVILSTEFGQVFTETLWLPETSSPASVKRIETFLQSYVRKQPPTEILSQKEEDLGMTLYNEVVVRYLTRYCNFSEEDLYQTGLSKLLKYDAFKDPDTLALGLSFFENRRHMCKLLDIGMHRDRPTAFIGNELSTIFGTPNPQCAVITTPYYMNRTPLGAFGVLGPINLPYREIFQTLTIFADKVKDSLTQSFYKFKLSFRRPCPSDPKLSKEPTLLARYSSIKLLPPKETS
What is the function of this protein?
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons).  Prevents heat-shock induction of these operons.
What are the official names of this protein?
Heat-inducible transcription repressor HrcA.
What is the protein family that this protein belongs to?
Belongs to the HrcA family.
Protein: PDE8A_MOUSE
Sequence: MGCAPSIHTSENRTFSHSDGEDEDVDVDVPGPAPRSIQRWSTAPGLVEPQPRDNGASKVSVADVQFGPMRFHQDQLQVLLVFTKEDSQCNGFHRACEKAGFKCTVTKEVQTVLTCFQDKLHDIIIIDHRYPRQMDAETLCRSIRSSKFSENTVIVGVVRRVDKEESSLMPFLAAGFTRRFIENPNVMACYNELLQLACGEVRSQLKLRACNSVFTALEKSQEAIEITSEDHIIQYANPAFESTMGYQSGELIGKELAQVPINEKKGDLLDAINSCVTVDKEWQGVYHTQKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKVETTTECVQTDSQTDNQAGKHKDRRKHSMDAKAVSSRTSDVSSQRRHSSLARIHSMMIEAPITKVINIINAAQENSPVPVTEALNRVLDILRTTELYSPQFNAQDDPHATDLVGGLMSDGLRRFSGNEYILATKNLPPLSNNLATPVSLHDVPPRIALAIENEEQWDFDIFELEVATQNRPLIYLGLKTFARFGMCEFLQCSETTLRSWFQMIESNYHSSNPYHNSTHAADVLHATAYFLSRDKIKETLDRIDEVAALIAATVHDVDHPGRTNSFLCNAGNQLAVLYNDTAVLESHHVALAFQLTLENDQCNIFKQMERNDYRTLRQSIIDMVLATEMTKHFEHVNKFINSINKPLTAQESEEPDRSLEDIKAMLKTPESRALIKRMMIKCADVSNPCRPLEHCIEWAARISEEYFSQTDEEKQLDLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPNLMQHLDDNFRYWKGLDEKKLRSLRPPPE
What is the function of this protein?
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.  May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.  Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling.  Protects against cell death induced by hydrogen peroxide and staurosporine.
What are the official names of this protein?
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MmPDE8.
What is the protein family that this protein belongs to?
Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
Protein: FABZ_VIBCH
Sequence: MMTLTTDKKTMNITEIQSLLPHRYPFLLIDRVTDYEEGKYLIGLKNVSVNEPQFTGHFPQLPVFPGVLILEAMAQATGLLAFKTFGAPKENELYYFASIDEAKFRKPVTPGDQLMVEVEFLKERRGIALFNGVAKVDGDVVCSAQLKCARREF
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CHLB_SPHCO
Sequence: KRSLRDLGIPVNQIIPEGGSLKDLKDLPRAWFNIVPYREVGLMTATFLEKEYGMPYVSVTPMGILDTAEFISQVEKLVNAWASVLSEERVNYMLYIQNQTRFV
What is the function of this protein?
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide).  This reaction is light-independent.  The NB-protein (ChlN-ChlB) is the catalytic component of the complex (By similarity).
What are the official names of this protein?
Light-independent protochlorophyllide reductase subunit B, DPOR subunit B, LI-POR subunit B.
What is the protein family that this protein belongs to?
Belongs to the ChlB/BchB/BchZ family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: QTRT2_SCHPO
Sequence: MAISSLSSPSGARVSSVTVKNKVLKTPCFFLPTSRGTVPHLTPDNVEEFDIPALYVGLEDCLDRLEASPILTNEGTIKKWIAAPSVQPTLLAPRRTSPLPSVSAGQSHINIVTASGAKKLTNDLYIKAVLKLCPELVIPLNDTPTSPPGVKRKPKIVERSVNWTTELLLALKATDAFNTTKVFFPVPDLDTQYLTPIFQFFQENQLANNIAGLAFSNNVNPLPADLVGLPRLSIQKFESPLEILKCIQRGIDIIVPDMITQATDAGVALTFSFPPPSKDVLNSKIELGLDMWDERFATDMEPLQSGCVCKTCRRYKRAYVRHLLQARELVAWILLQLHNVYAFTAFFQGIRASIQEGNFDEDVRKFEEIYMTSFPASHGFGPRKRGYQMDLTNVQPVENKPAWISMKSPLEKEIANEYEALKVTERKEDTQDYNEPELHNSNDPTVDLYADTYATQAATESDSELEDALFSQLDEFDDTAYREQRLEMLKKEFARVEAAKEKGHMQFLTVENEREVMDFTLSSKKVVIHFYHPDFIRCKIIDSHLEKIAKVHWETKFIRIEAANAPFLVVKLGLKVLPAVLCYVNSQLVDKIIGFADLGNKDDFETSLLEFRLLKSSAIDRLKEESSSNKSIYHDELQNNQSDDSDFFE
What is the function of this protein?
Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
What are the official names of this protein?
Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase domain-containing protein 1.
What is the protein family that this protein belongs to?
Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TM52B_HUMAN
Sequence: MGVRVHVVAASALLYFILLSGTRCEENCGNPEHCLTTDWVHLWYIWLLVVIGALLLLCGLTSLCFRCCCLSRQQNGEDGGPPPCEVTVIAFDHDSTLQSTITSLQSVFGPAARRILAVAHSHSSLGQLPSSLDTLPGYEEALHMSRFTVAMCGQKAPDLPPVPEEKQLPPTEKESTRIVDSWN
What are the official names of this protein?
Transmembrane protein 52B.
What are the subcellular locations of this protein?
Membrane; Single-pass type I membrane protein.
Protein: GOLM2_PONAB
Sequence: MVGFGANRRAGRLPSLVLVVLLVVIVVLAFNYWSISSRHVLLQEEVAELQGQVQRTEVARGRLEKRNSGLLLLVDTHKKQIDQKEADYGRLSSRLQAREGLGKRCEDDKVKLQNNISYQMADIHHLKEQLAELRQEFLRQEDQLQDYRKNNTYLVKRLEYESFQCGQQIKELRAQHEENIKKLADQFLQEQKQEAHKIQSNDGKELDINDQVVPKNIPKVAENVADKNEEPSSNHIPHGKEQIKRGGDAGMPGIEENDLAKVDDLPPALRKPPISVSQHESHQTISHIPTGQPLSPNMPPDSHVNHNGNPGTSKQNPSSPLQRLIPGSNLDSEPRIQTDILKQATKDRVSDFHKLKQSRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQDDEERELQMDPADYGKQHFNDVL
What are the official names of this protein?
Protein GOLM2, Cancer susceptibility candidate gene 4 protein homolog, CASC4, Golgi membrane protein 2.
What is the protein family that this protein belongs to?
Belongs to the GOLM family.
What are the subcellular locations of this protein?
Membrane; Single-pass type II membrane protein.
Protein: CYB_SOTGU
Sequence: MTNIRKTHPLMKILNNAFIDLPTPSSISSWWNFGSLLGLCLIMQILTGLFLAMHYTPDTSTAFSSVAHICRDVNYGWFIRYLHANGASMFFICLYAHIGRGLYYGSYMFQETWNIGVLLLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALAAVHLLFLHETGSNNPTGIPSNMDMIPFHPYYTIKDILGALLLILTLLALTLFTPDLLGDPDNYTPANPLSTPAHIKPEWYFLFAYAILRSIPNKLGGVLALLLSILILIFIPMLQTSKQRSMMFRPFSQLLFWTLIADLLTLTWIGGQPVEHPYIIVGQLASILYFLLILVLMPTVGLIENKLLKW
What is the function of this protein?
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain.  The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c.  Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
What are the official names of this protein?
Cytochrome b, Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit.
What is the protein family that this protein belongs to?
Belongs to the cytochrome b family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: SMTB_SYNE7
Sequence: MTKPVLQDGETVVCQGTHAAIASELQAIAPEVAQSLAEFFAVLADPNRLRLLSLLARSELCVGDLAQAIGVSESAVSHQLRSLRNLRLVSYRKQGRHVYYQLQDHHIVALYQNALDHLQECR
What is the function of this protein?
Transcriptional repressor of the expression of the smtA gene.  Binds two zinc ions per dimer.  The complex of DNA and SmtB is dissociated by zinc ions.
What are the official names of this protein?
Transcriptional repressor SmtB.
Protein: ATPE_ELUMP
Sequence: MKKLTFSFISPERPIVQNQEADFVALPAFEGEMGVLPGHVNSVVILMPGFVRFKNNGEEKEFAIIDGFAEVFKDHIDVFASEASLSEEKQSEEQKQRLERAKKALSSQDADIDIELAEIQLKTQILKMKMKKRKM
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.
What are the official names of this protein?
ATP synthase epsilon chain, ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit.
What is the protein family that this protein belongs to?
Belongs to the ATPase epsilon chain family.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RPOC1_DIOEL
Sequence: MIDQYKHQQLRIGPVSPQQIRAWANKILPNGEIIGEVTKPYTFHYKTNKPEKDGLFCERISGPIKSGICACGNYRVIGAEKEDPKFCEQCGVEFVDSRIRRYQMGYIKLACPATHVWYLKRLPSYIANLLDKPLKELEGLVYCDVFSFARPISKKPTFLRLRGSFEYEIQSWKYSIPLFFTNQSFETFRNREISTGAGAIREQLADSDLQIILNNSLVEWKELGDEEVIGTGNEWEDRKIRRRKDFLVKRMELAKHFIRTNVEPKRMVLCLLPVLPPELRPIIQIDGGKLMSSDINELYRRVIYRNNTLTDLLATSRSMPGELVMCQEKLVQEAVDTLLDNGIRGQPMKDGHNKVYKSFSDVIEGKEGRFRETLLGKRVDYSGRSVIVVGPSLSLHQCGLPREIAIELFQTFLIHGLIKQHVASNIGIAKSKIREKEPIVWEILQEVMRGHPILLNRAPTLHRLGIQAFQPILVEERAICLHPLVCRGFNADFDGDQMAVHVPLSLEAQAEARLLMFSHMNLLSPAIGDPISVPTQDMLIGLYVLTIGNRRGICANRYNTYNCRNSQNKILNNNKYNYIKMKATYCCSSYDALGAYRQKRIDLDSPLWLRWRLDQRVIGSREVPIEIQYESLGTYHEIYRHYLIVRSVKKKIRWIYIRTTIGHISFYREIEEAVQGFCWAYSYVI
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', PEP, Plastid-encoded RNA polymerase subunit beta', RNA polymerase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family. RpoC1 subfamily.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: FANCE_HUMAN
Sequence: MATPDAGLPGAEGVEPAPWAQLEAPARLLLQALQAGPEGARRGLGVLRALGSRGWEPFDWGRLLEALCREEPVVQGPDGRLELKPLLLRLPRICQRNLMSLLMAVRPSLPESGLLSVLQIAQQDLAPDPDAWLRALGELLRRDLGVGTSMEGASPLSERCQRQLQSLCRGLGLGGRRLKSPQAPDPEEEENRDSQQPGKRRKDSEEEAASPEGKRVPKRLRCWEEEEDHEKERPEHKSLESLADGGSASPIKDQPVMAVKTGEDGSNLDDAKGLAESLELPKAIQDQLPRLQQLLKTLEEGLEGLEDAPPVELQLLHECSPSQMDLLCAQLQLPQLSDLGLLRLCTWLLALSPDLSLSNATVLTRSLFLGRILSLTSSASRLLTTALTSFCAKYTYPVCSALLDPVLQAPGTGPAQTELLCCLVKMESLEPDAQVLMLGQILELPWKEETFLVLQSLLERQVEMTPEKFSVLMEKLCKKGLAATTSMAYAKLMLTVMTKYQANITETQRLGLAMALEPNTTFLRKSLKAALKHLGP
What is the function of this protein?
As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair.  Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.
What are the official names of this protein?
Fanconi anemia group E protein, Protein FACE.
What are the subcellular locations of this protein?
Nucleus.