PharMolix/UniProtQA huggingface dataset:
Protein: YGFB_ECOLU
Sequence: MSIQNEMPGYNEMNQYLNQQGTGLTPAEMHGLISGMICGGNDDSSWLPLLHDLTNEGMAFGHELAQALRKMHSATSDALQDDGFLFQLYLPDGDDVSVFDRADALAGWVNHFLLGLGVTQPKLDKVTGETGEAIDDLRNIAQLGYDEDEDQEELEMSLEEIIEYVRVAALLCHDTFTHPQPTAPEVQKPTLH
What are the official names of this protein?
UPF0149 protein YgfB.
What is the protein family that this protein belongs to?
Belongs to the UPF0149 family.
Protein: NDK_RALSO
Sequence: MAIERTLSIIKPDAVAKNVIGQIYARFEGAGLKVVAAKMIHLSRAEAEQFYAVHKERPFFKDLVDFMISGPVMVQALEGESAIVKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAAETAAVEVAFFFPGLNIYSR
What is the function of this protein?
Major role in the synthesis of nucleoside triphosphates other than ATP.  The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
What are the official names of this protein?
Nucleoside diphosphate kinase, NDK, NDP kinase, Nucleoside-2-P kinase.
What is the protein family that this protein belongs to?
Belongs to the NDK family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: SOPB_SALDU
Sequence: MQIQSFYHSASLKTQEAFKSLQKTLYNGMQILSGQGKAPAKAPDARPEIIVLREPGATWGNYLQHQKTSNHSLHNLYNLRRDLLTVGATVLGKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIELIAARTQQQDGLPAKEAHRFAAVAFRDAQDKQLNNQPWQTIKNTLTHNGHHYTNTQLPAAEMKIGAKDIFPSAYEGKGVCSWDTKNIHHANNLWMSTVSVHEDGKDKTLFCGIRHGVLSPYHEKDPLLRQVGAENKAKEVLTAALFSKPELLNKALAGEAVSLKLVSVGLLTASNIFGKEGTMVEDQMRAWQSLTQPGKMIHLKIRNKDGDLQTVKIKPDVAAFNVGVNELALKLGFGLKASDSYNAEALYQLLGNDLRPEARPGGWVGEWLAQYPDNYEVVNTLARQIKDIWKNNQHHKDGGEPYKLAQRLAMLAHEIDAVPAWNCKSGKDRTGMMDSEIKREIISLHQTHMLSAPGSLPDSGGQKIFQKVLLNSGNPGDSEPNTGGAGNKVMKNLSPEVLNLSYQKRVGDENIWQSVKGISSLITS
What is the function of this protein?
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2.  It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC).  Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements.  The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cells.
What are the official names of this protein?
Inositol phosphate phosphatase SopB, Effector protein SopB.
What is the protein family that this protein belongs to?
Belongs to the phosphatase IpgD/SopB family.
What are the subcellular locations of this protein?
Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS).
Protein: DZAN1_MOUSE
Sequence: MTAGSVCAPQIIPLRVPQPGKANHEIDTNTLLEMKSDTPDVNIYYTLDGSKPDFLKKVGSGENNTFKYVKPITLPDGKIQVKAVAVSKDCRQSGIVTKVFQVDYEPPKMVSSEDNVEDALKGFSKQELKNGFVGPKLRKKYKNAENKSTWNVNLRRLADLKVGERADPKTLKDLRFAESPLEIPAYHEGASARLPTHQAQSPGFAHITGQKSLTSTEIMRIQRETDFLKCAHCLASRPSDPFARFCHECGAPVPPIFGYRLPPPEGAQMGLCAECGSMVPMNTPICVVCEAPLAPQLRPQASLYLKERVICRTCGTGNPAHLRYCVTCEGPLPPTQEQWLCNGDEVPHPPARNGETISCSRCGCQNLWEASFCDWCGAMLGISASHSVCPKCGASNHLTARFCGSCGIYVKSITRFRMHNSLAIVAGAPRPFPEPRSAWQSLNVPLPTSASGSKKDTGTQTSGLFYPSGKLLAKKELEAASHRQRQEKMSDHRPVLTAVSPGRGYWRKQLDHISAHLRSYAQNNPEFRALIAEPRMGKLISATVHEDGYEVSIRLNYIQVSNKSLYFNKSVNLSDHFLSSVTEGGNGLYDSRSSLVSAYSQSVSDTPESIKKMKNLKAKSFLVNPEPLTPENKLLLEEVGSSGKGRLSVLEQLLDEGADPNCCDSQGRPAVIVAVVNKHYEAIPVLAQRGADIDQQWGPFRNTALHEATLLGLEGRESIATLLGCNANAQKKNTRGQTAYDIALEMGDDLTSSLFAAKFTQGLEDQLSPPGNRILGDS
What are the official names of this protein?
Double zinc ribbon and ankyrin repeat-containing protein 1.
Protein: NUOA_RHOPB
Sequence: MGDFLFPIDSGAALAIHVALSAGIVAAIIGVAAVLREKRAGARPDTPYEGGVLPAAPPQGPQNAPYFLIAALFVIFDMEAAILFAWAVAAREAGWVGLIEAAIFIGVLLLALVYLWIDGALDWGPGERK
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit A, NADH dehydrogenase I subunit A, NDH-1 subunit A, NUO1.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 3 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: U79_HHV6U
Sequence: MYAEERAYGSFDDVMEVYQQIVTESIQLKRLHFGSGCLIEFLGDSGTCETFCGGWISMICWTSDTNSMGSLTVDIGIDDGKYKTYNARGFLLCSKSITSISQNTEGRDRILTVSQENNKLQITFVTLTKVFKEHDIRNLGDPKCIEKFEKECRALDRKKHDDEHRKRSGKQKEKRKVEDTDKKKDDDRRKQEERKRNDEDKQPDKKEESDELPKEKRQKYHDMKRNLEEQSHEDGITLTSTTLVNGAVEGALPPCISIDNHEDQQHDELDKRAYAQGTNREGLSNEDNYGNFRLNKSLEQLRAKLVASSGDIVERSLLKLKECLDNVKDNLIKNECADVTGPSKCLSKTKHIEPKKQIVFSDCVRPVPVCEIKPFIDVRLFETARSPRRLRQRTRTIVGSTDGAIEQQRVISGQNRGRARGRGRGRAPRRRNSNINNSRTQTTIVIDDSSEAENFENEGSFNEDLLATTILETL
What is the function of this protein?
May be involved in DNA replication.
What are the official names of this protein?
Protein U79/U80.
What is the protein family that this protein belongs to?
Belongs to the herpesviridae U79/UL112 family.
What are the subcellular locations of this protein?
Host nucleus.
Protein: BIOB_LAWIP
Sequence: MRNDWTFKEAKQIFNLPLLELLYKAQTIHRKYFDPNKIQISMLLNIKTGNCPENCGYCSQSSHYKTDLQKEPLVDIDTLISEAKKAKELGSTRFCMGAAWRSPLDKDLKIVCQMIEEVKKLGLETCVTLGFLKEHQIAMLKKAGLDFYNHNMNTSPEFYEHIATTHTFDDRLATLKAVRKFGIKLCSGGIIGLGETIDDRISMLLLLATLEEQPESVPINRFVKVAGTPLNPQSDIDPFDFVRIIALTRILMPKSYIRLAAGREQMSDELQTLCFMGGANSIFYGGRLLTTDGPQPEQDDLLFQKIGLEKVQTICH
What is the function of this protein?
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
What are the official names of this protein?
Biotin synthase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. Biotin synthase family.
Protein: 1433Z_SHEEP
Sequence: MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNRSQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
What is the function of this protein?
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways.  Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif.  Binding generally results in the modulation of the activity of the binding partner.  Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB.  Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity).  In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
What are the official names of this protein?
14-3-3 protein zeta/delta, Protein kinase C inhibitor protein 1, KCIP-1.
What is the protein family that this protein belongs to?
Belongs to the 14-3-3 family.
What are the subcellular locations of this protein?
Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.
Protein: GNGF_VIBCH
Sequence: MSLYENKKVVAIGGGHGLGRMLAALKVFGSNATGIVTTTDNGGSTGRIRHCQGGIAWGDTRNCINQLITEPSISSMMFEYRFKGAGELNGHNLGNLMLTALDNLSVRPLDAINLIRNMLKVDVNILPMSEHPSDLAALAMDGKWVTGETSVDEMTQDLRRLDLAPEVPATKEAVTAIQDADCVILGPGSFLTSVMPPLLLPELGKAIARNQTAKVIFVENLSPEYGPAGRMSLEQKLEWCERACQGRKIDVVLGHHPHPELEQRWNFVTRDLASANRDWRHDRQKLRQAIEEQLMN
What is the function of this protein?
Required for morphogenesis under gluconeogenic growth conditions.
What are the official names of this protein?
Putative gluconeogenesis factor.
What is the protein family that this protein belongs to?
Belongs to the gluconeogenesis factor family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NHAP2_VIBC3
Sequence: MDAVTINSFFMIGALLIGISVLLSPVSSKLGIPILLVFLAVGMLAGEDGIGQIAFDNYPVAYLVSNLALAIILLDGGMRTRVASFRVAFWPSVSLATLGVAVTTLLTGLLAMWLFNLSLLQGVLVGAIVGSTDAAAVFSLLKGRSLNERVGATLEIESGTNDPMAVFLTVTLIAVLGSAETNLSAGFLLLSFAQQFGVGALLGLAGGWILWWLINRNQLPEGLYSILAVSGGLMIFALSNALGGSGILSIYLTGLLLGNRPTRSRHAILNVLDGMTWLAQIGMFLVLGLLVTPSELMEIALPGLALAVGMILFARPIAVWIGLAPFKSFTAREKWFVSWVGLRGAVPIILAVFPMMAGLPNAQLYFNLAFFVVMVSLVVQGGTLTKAMSLAKVELPPKPEPISRTGVEIYPTSEWELFIYKLKADKWCIGEPLRNLFMPEGTRIAAVFRDNQLLHPSGSTELCEGDTLCVMAQERDLESLSRLFSEAPEKASLARFFGDFFLDIEAKLQDVALLYGLDLGELEADAKLKDLVLEHLGETPVLGDYFEWHGLQWVVADVVDWKVTKIGLRLPPEEELQEGAE
What is the function of this protein?
K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels (PubMed:20163190).  In vitro, can also catalyze Rb(+)/H(+), Na(+)/H(+) and, possibly, Li(+)/K(+) exchange, but not Li(+)/H(+) exchange.  Nonelectrogenic antiporter that exchanges one cation per proton (PubMed:20163190).
What are the official names of this protein?
K(+)/H(+) antiporter NhaP2, Potassium/proton antiporter NhaP2.
What is the protein family that this protein belongs to?
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: GUAC_STRGC
Sequence: MLNDFQVFDYEDIQLIPAKCVVKSRAEADTRVKFGNHTFRLPVVPSNMQTIIDESVAEELARGGYFYIMHRFDEEGRKPFVKQMHEKGLIASISVGVKDYEYDFVSSLKEDAPEYITIDIAHGHSDSVIKMIQHIKKELPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLSALRWCSKVARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHIESPGETIEIDGDKFKEYYGSASEYQKGAYKNVEGKKILLPAKGHLQDTLTEMEQDLQSSISYAGGRDLHSLTRVDYVIVKNSIWNGDAH
What is the function of this protein?
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP.  It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
What are the official names of this protein?
GMP reductase, Guanosine 5'-monophosphate oxidoreductase, Guanosine monophosphate reductase.
What is the protein family that this protein belongs to?
Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
Protein: MSS4_DROME
Sequence: MTEEADFSEQITDGKNKSNVRCQFCNCLMLKAQEGTYNQEEVDVPLMTQKQDRTADSLNSEPLKDFWLVKDMMTFENIGFSNTVDGRKFLVCADCERGPVGYHDLSTRHCYLALKRVVHKDT
What is the function of this protein?
Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8.  During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells.  Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side of the FE cells.  This function is independent of the Crag/Rab10 regulation of polarized BM protein secretion in the FE.
What are the official names of this protein?
Guanine nucleotide exchange factor MSS4 homolog, Guanine nucleotide exchange factor stratum.
What is the protein family that this protein belongs to?
Belongs to the DSS4/MSS4 family.
What are the subcellular locations of this protein?
Basal cell membrane; Peripheral membrane protein. Note=Diffuse intracellular localization early in oogenesis which later becomes basally enriched in follicular epithelial cells.
Protein: HSLU_MARN8
Sequence: MSAMTPREIVHELNKHIVGQEEAKRAVAIALRNRWRRMQLDSSLRDEITPKNILMIGPTGVGKTEIARRLAKLADAPFLKVEATKFTEVGYVGRDVESIIRDLADMAVKMLREQEMKRHEHRALDAAEDRILDALLPPPRDFNEDSQRTNADSSTRQLFRKKLREGELDDKEIEIDLRSSGAGVEIMAPPGMEEMTSQLQSMFSNLSSDKRKTRKMKVADAMKRVKDEEAAKLVNEEEIKQKAIQAVEQNGIVFIDEIDKVAKRSENTSSDVSREGVQRDLLPLIEGSTVSTKYGSIRTDHILFIASGAFHLSKPSDLIPELQGRLPIRVELQALTPDDFKRILTEPDASLVQQYEALMGTEGVKLTFADDAIARIAEVAYKVNETTENIGARRLHTVLERLLESLSYDAGDQVTDTFEVTADYVDEKLGELSEDEDLSRYIL
What is the function of this protein?
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity.  The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV.  HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
What are the official names of this protein?
ATP-dependent protease ATPase subunit HslU, Unfoldase HslU.
What is the protein family that this protein belongs to?
Belongs to the ClpX chaperone family. HslU subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZN215_PONAB
Sequence: MQPLSKLMAISKPQNLSLHEQREVLRADMCWQQETIPVMETHDSEASRQKFRHFQYLKVSGPHEALSQLRELCLQWLRPEIHTKKQIIEQLVLEQFLAILPEEVRTWVHLQHPNNSEDMVTLIEDVIEMLEDEGMPCKDSAPQMGSIKEKMKAGSPTGKPQEPVTFKDVVVEFSKEEWGQLDSAVKNLYRNVMLENFRNLNSLRKAHLLSKPFESLKLESRKKRWIMEKEIPRKTIFDMKSISGEESSHGVIVTRLTESGHPSSDVWKGENWLYRNQKKWDINLPQEAFIPETSYTDEEDFECSENKETFDINSVSSICAIQQGIPSRKGSPKCDKFKTQFKFNLDSVGKQHSEYEYVNDLSLRTDIRHQKSHTTMNSYECYQCGKAFCRSSSLIRHQIIHTGEKPYKCSECGRFFNRRTNLTKHQKLHAEVKACTSNKCGKAVSKSEDGNNPALHFGNNFYECVNCGKSFNRSSSLIRHQMIHTGEKPFKCKECNKAFNRSSNLVKHQKLHTRDKS
What is the function of this protein?
May be involved in transcriptional regulation.
What are the official names of this protein?
Zinc finger protein 215.
What is the protein family that this protein belongs to?
Belongs to the krueppel C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus.
Protein: MCA1A_ASPNC
Sequence: MNPHHSHHHSSYGGGGYPGQAYRQQQPPSNPYQYNQPSPQPYQGSQPPQNGYNGGYPAASQGPMYGGRPGIADVYHNSYNQGNHSAPAPPPSDPVSFGQGAPQGYNFQYSRCTGKRKALLIGINYFNQKGQLRGCINDVKNMSTYLNQNFGYAREDMVVLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEDDGYDEVIYPVDFRAAGHIVDDEMHRIMVKPLQPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMSSMMSTAVGFFKKATKGDEAYERTIQTKTSPADVVMWSGSKDDQTSQDAQIAGQATGAMSWAFISALRKNPQQSYVQLLNSIRDELSAKYTQKPQLSCSHPLVAL
What is the function of this protein?
Involved in cell death (apoptosis).
What are the official names of this protein?
Metacaspase-1A.
What is the protein family that this protein belongs to?
Belongs to the peptidase C14B family.
Protein: SYI_BUCAT
Sequence: MDDYKDTLNLPKTLFSMRGNLSKKEPNILKSWNENNLYKLIRKKNQEKKIFFLHDGPPYANGNIHIGHAVNKILKDIIIKSKNMSGFDAPYIPSWDCHGLPIEQKVEEKIKSNQGEISTTEFQEKCRKYAQDQVEKQKKDFIRLGVIGDWDNPHLTMNFKNEANIIKTLSKIVQKKHLYQDFKPIHWCLKCASSLSEAEIEYSKKKSDSIIVGFKFKYRSIIEKLFDFQISNKKEIHLLIWTTTPWTLPSSKAISIHPDFQYQLIETERCYLIIAKELVEKTLNTLKIKKSIIRNYVKGRFLEKMICLHPFLKNIDLPVILGKHVTLESGTGAVHTAPDHGLEDYIISQKYNIKTSNIVNFKGEYISNTHDKLDGVNVLEANSIIIELLIKNNTFFHHESLIHSYPHCWRHKSPVIYRATPQWFIDIDQKQLRIKLLQEIKKVRWIPEWGESRIGEMIKKRPDWCISRQRKWGVPMSIFIHKNTRKIHPNTFVFMKKIAKKVELEGLQVWWNIDSKEILGEEYQSYEKILDILDVWFESGNTHTTINYKNKNYTKKNADMFLEGSDQHRGWFMSSLIISTLISEKKPYSEVLTHGFVVDGKGQKMSKSIGNTISPNEIVDTLGADILRLWVASSNYSNDISISNEILKSSSDIYRRIRNTARFMLANISDFDPKKNIISKENMVLLDKWAIGQTKIVQEEIIQHYNNYNFHAVIQRLMYFCSIEMGSFYLDIIKDRQYTLKKHSQERRSSQTAIYYIINSLVRWIAPILSFTADEIWSYLPENNSQYVFMEEWFDKLFYLDQDDLFNYQFWNEIITIKHEINKFLEEAIQNKTINNSLETSIILYVSHELSNKLKILEQETKFIFLTSDIQIKLYDTAPKNAKKSKIVPYLKVSLEKIKGKKCPRCWHYFNFTKKNIKNSDICNRCILNTIGNGEKRIFI
What is the function of this protein?
Catalyzes the attachment of isoleucine to tRNA(Ile).  As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities.  One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP.  The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
What are the official names of this protein?
Isoleucine--tRNA ligase, Isoleucyl-tRNA synthetase, IleRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ABCB6_RAT
Sequence: MVTVGNYCEAEGPAGPAWTQNGLSPCFFYTLVPSTLMTLGVLALVLVLPCRRREVPAGTEELSWAAGPRVAPYALQLSLAILQMALPLASLAGRVGTARGVRLPGYLLLASVLESLASACGLWLLVVERSQARQSLAMGVWMKFRHSLGLLLLWTVTFAAENLVLVSWNSPQWWWSRADLGQQVQFGLWVLRYMTSGGLFILGLWAPGLRPQSYTLHVNEEDQDGGRNQGRSTDPRSTWRDLGRKLRLLSGYLWPRGSPSLQLTVLLCMGLMGLDRALNVLVPIFYRDIVNLLTSKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFNIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIMVTEWRAKFRRDMNTQENATRARAVDSLLNFETVKYYNAEGYELERYREAILKFQGLEWKSTASLVLLNQTQNMVIGFGLLAGSLLCAYFVSERRLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFHKGRVEFENVHFSYADGRETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEIQAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVVAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEDS
What is the function of this protein?
ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (By similarity).  May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (By similarity).  May play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (By similarity).  In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (By similarity).  In addition may play a role in the transition metal homeostasis (PubMed:18160489).
What are the official names of this protein?
ATP-binding cassette sub-family B member 6, ABC-type heme transporter ABCB6, Ubiquitously-expressed mammalian ABC half transporter.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Lysosome membrane. Late endosome membrane. Early endosome membrane. Secreted, extracellular exosome. Mitochondrion. Endosome, multivesicular body membrane. Melanosome membrane. Note=Present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation. Traffics from endoplasmic reticulum to Golgi during its glycans's maturation, therefrom is first targeted to the plasma membrane, and is rapidly internalized through endocytosis to be distributed to the limiting membrane of multivesicular bodies and lysosomes. Localized on the limiting membrane of early melanosomes of pigment cells (By similarity). Targeted to the endolysosomal compartment (PubMed:18160489).
Protein: ANMK_CROS8
Sequence: MKSGRYIGVMSGTSLDGVDVVLAAIDEHMVAQQASLSWPMPPEIKKAILDICQGQPLTLSQLGRLDHQLGCLFADAVNALMEQQKLKPEDVMAIGCHGQTVWHEPTGSAPHTMQIGDNNQIVARTGVSVVGDFRRRDMALGGQGAPLVPAFHQALLAHPTERRMVLNIGGIANLSLLFPGQPVKGFDTGPGNMLMDAWIWRQKGKPFDKDGEWAASGNVVQPLLQKMLRDPYFSTPAPKSTGREYFNYGWIERQLSSFAGLPAQDVQATLLELTASTIARDVQLSGGAERLMICGGGGRNPRLVARLAALLPGTEVSSTDEMGIRGDDMEALAFAWLAYRTLSGKPGNLPSVTGAREASVIGAVFPANPLNNRSLPTFPAPPGR
What is the function of this protein?
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P.  Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
What are the official names of this protein?
Anhydro-N-acetylmuramic acid kinase, AnhMurNAc kinase.
What is the protein family that this protein belongs to?
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Protein: TRUB_BRUC2
Sequence: MARRGKKKGRPISGWVIFDKPKGMGSTEAVSKIKWLFSAEKAGHAGTLDPLASGMLPIALGEATKTVPYVMDGTKVYRFTVTWGEERSTDDLEGQPTKTSDKRPSREEVEALLPDYTGVISQVPPQFSAIKIDGERAYDLAREGETVEIPTREVEIDRLEIVGFPDADRTEFEVECSKGTYVRSLARDMGRDLGCYGHISDLRRVEVAPFTDEDMVTLAKLEAVWPPLPPKDEDGNVIEPAPRRDFSALDALVIDTGAALDCLPQVPLSDDQAQRVRLGNPVILRGRDAPLEADEACVTTRGKLLAIGYIEHGQFKPKRVFTAG
What is the function of this protein?
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
What are the official names of this protein?
tRNA pseudouridine synthase B, tRNA pseudouridine(55) synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase.
What is the protein family that this protein belongs to?
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Protein: HIS2_BURMA
Sequence: MTQSTTEDTLLRLAAVIDSRKGGDPEQSYVSRLFHKGDDAILKKIGEEATEVVLAAKDVRQGGAPSALVGEVADLWFHCLVALSHFDLSPADVIAELERREGMSGIEEKALRKRREREENGG
What are the official names of this protein?
Phosphoribosyl-ATP pyrophosphatase, PRA-PH.
What is the protein family that this protein belongs to?
Belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMG_HYPNA
Sequence: MSERDDRAAFLAANDVSRETLDRLDRVIDTLDVWRQKSNLIGPKEWPQIWTRHVGDSWQLLDHIPETAHLVDLGSGAGFPGLIIAAARSLGHVTMIESVGKKCAFLRAAIQEADLSAAVHQGRVEAAPPIKAEFVTARAFAPLPELLDYAAPWLRKGAVGVFPKGERWNEELTAARQRWNFAYEAIPSRSGGSGVILIIREVARRND
What is the function of this protein?
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase G, 16S rRNA 7-methylguanosine methyltransferase, 16S rRNA m7G methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RS2_BRUSI
Sequence: MALPDFSMRQLLEAGVHFGHQTHRWNPKMAPFIYGERNNIHILDLSQTVPLLNSALKVVSDTVARGGRVLFVGTKRQASDIIADAANRSAQYYVNARWLGGMMTNWKTISNSIQRLRKLDELLAGEAQGFTKKERLNLEREREKLDRALGGIKDMGSVPDLMFIIDTNKEAIAIQEAKRLGIPVVAVIDSNCDPDQIDYPIPGNDDAARAIALYCDLIARAALDGIARQQGAMGIDVGAQVEAPVEPALQAPAEGA
What are the official names of this protein?
30S ribosomal protein S2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS2 family.
Protein: PSD_PELPB
Sequence: MFTSYGYSTMIKVFLLCLAISAAALIFPLWAQIPIHLTTGLALLFTLYFFRDPKRVAPDEKRIILAPADGKILLVQKQNGNIAGKTSTLVSIFMSPLNVHVNRVPLSGKVTRLHYRPGQFLMAFDNRSMESNEKMEIGINNGEIEVQFSQVSGFLARRIVCQLQKGENVKLGNRFGMIKFGSRVDLILPPSATVLLQPGQRTRAGETILARY
What is the function of this protein?
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
What are the official names of this protein?
Phosphatidylserine decarboxylase proenzyme.
What is the protein family that this protein belongs to?
Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: HYCC2_HUMAN
Sequence: MLGTDRCVVEEWLSEFKALPDTQITSYAATLHRKKTLVPALYKVIQDSNNELLEPVCHQLFELYRSSEVRLKRFTLQFLPELMWVYLRLTVSRDRQSNGCIEALLLGIYNLEIADKDGNNKVLSFTIPSLSKPSIYHEPSTIGSMALTEGALCQHDLIRVVYSDLHPQRETFTAQNRFEVLSFLMLCYNSAIVYMPASSYQSLCRMGSRVCVSGFPRQHEKHWKELCGRIVLDPEFMVQLLTGVYYAMYNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDSTQEGQKVLKVEVTPTVPRISRTAITTASIRRHRWRREGAEGVNGGEESVNLNDADEGFSSGASLSSQPIGTKPSSSSQRGSLRKVATGRSAKDKETASAIKSSESPRDSVVRKQYVQQPTDLSVDSVELTPMKKHLSLPAGQVVPKINSLSLIRTASASSSKSFDYVNGSQASTSIGVGTEGGTNLAANNANRYSTVSLQEDRLGQAGEGKELLSPGAPLTKQSRSPSFNMQLISQV
What is the function of this protein?
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.
What are the official names of this protein?
Hyccin 2.
What is the protein family that this protein belongs to?
Belongs to the Hyccin family.