PharMolix/UniProtQA huggingface dataset:
Protein: ILDR1_HUMAN
Sequence: MAWPKLPAPWLLLCTWLPAGCLSLLVTVQHTERYVTLFASIILKCDYTTSAQLQDVVVTWRFKSFCKDPIFDYYSASYQAALSLGQDPSNDCNDNQREVRIVAQRRGQNEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCTIEAPGDTSGDPDKEVKLIVLHWLTVIFIILGALLLLLLIGVCWCQCCPQYCCCYIRCPCCPAHCCCPEEALARHRYMKQAQALGPQMMGKPLYWGADRSSQVSSYPMHPLLQRDLSLPSSLPQMPMTQTTNQPPIANGVLEYLEKELRNLNLAQPLPPDLKGRFGHPCSMLSSLGSEVVERRIIHLPPLIRDLSSSRRTSDSLHQQWLTPIPSRPWDLREGRSHHHYPDFHQELQDRGPKSWALERRELDPSWSGRHRSSRLNGSPIHWSDRDSLSDVPSSSEARWRPSHPPFRSRCQERPRRPSPRESTQRHGRRRRHRSYSPPLPSGLSSWSSEEDKERQPQSWRAHRRGSHSPHWPEEKPPSYRSLDITPGKNSRKKGSVERRSEKDSSHSGRSVVI
What is the function of this protein?
Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027).  Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs.  Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine.  In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity).
What are the official names of this protein?
Immunoglobulin-like domain-containing receptor 1, Angulin-2.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. LISCH7 family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytosol.
Protein: RS19_HELPY
Sequence: MSRSIKKGPFIDDHLMKKTLKAKEGKDNRPIKTWSRRSTILPEMIGFTYNVHNGRVFIPVYITENHVGYKLGEFAPTRTFKGHKGSVQKKIGK
What is the function of this protein?
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S19.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS19 family.
Protein: TKFC_PIG
Sequence: MTSKKLVNSVAGCADDALAGLVACNPSLQLLQGHRVALRSDLDSLKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTSPAVGSILAAIRAVAQAGTVGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVVGDDSAFTVLKKAGRRGLCGTVLIHKVAGALAEAGVGLEEITNRVSVVAKAMGTLGVSLSSCSVPGSRPTFELSADEVELGLGIHGEAGVLRIKMATADEIVAHMLNHMTDSSNVSHVPVQSGSSVVLMVNNLGGLSYLELGIIADAAVRFLEGRGVKIARALVGTFMSALEMPGVSLTLLLVDEPLLKLIDAETTAAAWPNVAKVSVTGRKRSRAAPAEPPEAPDATAAGGATSKQMVRVLERVCTTLLGLEDQLNALDRAAGDGDCGTTHSRAARAIQGWLKESPPPASPAQLLSKLSLLLLEKMGGSSGALYGLFLTAAAQPLKAKTDLAAWSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGANLLPVLTKALLENAEAAAEATKNMEAGAGRASYISSARLDQPDPGAVAAAAILRAILEVLQSQGA
What is the function of this protein?
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate (PubMed:7831203).  Represses IFIH1-mediated cellular antiviral response (By similarity).
What are the official names of this protein?
Triokinase/FMN cyclase, Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing).
What is the protein family that this protein belongs to?
Belongs to the dihydroxyacetone kinase (DAK) family.
Protein: FLA2_BARBA
Sequence: GAAILTNDNAMDALQDL
What is the function of this protein?
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.  Flagella are an important component in the invasiveness of B. bacilliformis.
What are the official names of this protein?
Flagellin.
What is the protein family that this protein belongs to?
Belongs to the bacterial flagellin family.
What are the subcellular locations of this protein?
Secreted. Bacterial flagellum.
Protein: OB99A_DROME
Sequence: MKVFVAICVLIGLASADYVVKNRHDMLAYRDECVKELAVPVDLVEKYQKWEYPNDAKTQCYIKCVFTKWGLFDVQSGFNVENIHQQLVGNHADHNEAFHASLAACVDKNEQGSNACEWAYRGATCLLKENLAQIQKSLAPKA
What is the function of this protein?
Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
What are the official names of this protein?
General odorant-binding protein 99a.
What is the protein family that this protein belongs to?
Belongs to the PBP/GOBP family.
What are the subcellular locations of this protein?
Secreted.
Protein: UREE_BURVG
Sequence: MRTLDKRIAPNVKLAASLVARAPTLTLAFDARCKSRVAATLDTGEDVAVLLPRGTVLRDGDVLVADDGALVRIVAAPETVLLVRAHDPLTLMRAAYHLGNRHTPVEIGDGYLKLEADPVLADMLRRLGTQVDETQAPFQPEAGAYGGGHKHGHDATFAEDYALAQQVFGEHHGHAHPHPHDHDHQHGPGCAHGRHGHDHH
What is the function of this protein?
Involved in urease metallocenter assembly.  Binds nickel.  Probably functions as a nickel donor during metallocenter assembly.
What are the official names of this protein?
Urease accessory protein UreE.
What is the protein family that this protein belongs to?
Belongs to the UreE family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PP4C_RAT
Sequence: MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMTCRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL
What is the function of this protein?
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration.  The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.  The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA DSB repair.  Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity).  In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity).
What are the official names of this protein?
Serine/threonine-protein phosphatase 4 catalytic subunit, PP4C, Pp4.
What is the protein family that this protein belongs to?
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Protein: RNH2_PARMW
Sequence: MGLKPPLKTRNPRNPAVAGVGLRPQPLLIDSIPCHRGVAGVDEVGRGCLFGPVFAGAVVLEAANASRLQQEGLTDSKRLSARRRGDLVPLIEHEAEAWGLGQSSTREIDRLGIRPATELAMLRALQRLPNRPELVLVDGNLPLRPWTGEQRSIVAGDQHSLAIAAASVIAKQCRDALMQRLSQRFPGYGLERHAGYGTALHRAALLDLGPSALHRRSFLRRFLG
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease HII, RNase HII.
What is the protein family that this protein belongs to?
Belongs to the RNase HII family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PHNC_ECOUT
Sequence: MQTIIRVEKLAKTFNQHQALHAVDLNIHHGEMVALLGPSGSGKSTLLRHLSGLITGDKSVGSHIELLGRTVQREGRLARDIRKSRAHTGYIFQQFNLVNRLSVLENVLIGALGSTPFWRTCFSYFTREQKQRALQALTRVGMVHFAHQRVSTLSGGQQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYALRYCERIVALRQGHVFYDGCSQQFDNERFDHLYRSINRVEENAKAA
What is the function of this protein?
Part of the ABC transporter complex PhnCDE involved in phosphonates import.  Responsible for energy coupling to the transport system.
What are the official names of this protein?
Phosphonates import ATP-binding protein PhnC.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: SOT14_ARATH
Sequence: MAIPSFSMCHKPELLKEGKSEGQEEEGLSYEFQEMLDSLPKERGRRNRYLYLFQGFRCQAKEIQAITSFQKHFQSLPDDVVLATIPKSGTTWLKALTFTILTRHRFDPVSSSSSDHPLLTSNPHDLVPFFEYKLYANGNVPDLSGLASPRTFATHVPFGALKDSVENPSVKVVYLCRNPFDTFISMWHYINNITSESVSAVLLDEAFDLYCRGLLIGFGPFWEHMLGYWRESLKRPEKVLFLKYEDLKEDIETNLKKLASFLGLPFTEEEEQKGVVKAIADLCSFENLKKLEVNKSSKLIQNYENRFLFRKGEVSDLVNYLSPSQVERLSALVDDKLAGSGLTFRLS
What is the function of this protein?
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor.  Not active with 11-hydroxyjasmonate or 12-hydroxyjasmonate.
What are the official names of this protein?
Cytosolic sulfotransferase 14, AtSOT14, Sulfotransferase 2b, AtST2b.
What is the protein family that this protein belongs to?
Belongs to the sulfotransferase 1 family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: CAPM_STAAU
Sequence: MKNQKIFHLVTVSKSIPLMRGQIEFLRKKNMDVHIVSSDGKELKQYDNEIAHVIPMKRDIALFSDLKSLLKMILLFHKEKPFIVNSGTPKAGLIGTIAAFITQRPIRIYTVRGLRLETVKGFKYFVLYLMEKIAMFCATDIIAISESLKHKIITSNLAKENKITVLGFGSSNGIQFEKFQLDNNKLEEKYHKLLNDNFVIGYVGRIVKDKGIHELIQSFKIIVSKGYNVKLLVIGSLETENSIDESDYLFLTQNPNVVLIKHVSDPISFYNNMNVFVFPTHREGFGNVSIEAQALEVPVITTNVTGAIDTVVNGETGFIVEKGDFKAIAEKIEKLINDESLRETIGHNGRKRVENKFSSQIIWEELESMYNTFLKESEGK
What is the function of this protein?
Required for the biosynthesis of type 1 capsular polysaccharide.
What are the official names of this protein?
Capsular polysaccharide biosynthesis glycosyltransferase CapM.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Protein: RS6_CELJU
Sequence: MRHYEVVVLIHPDQSEQVPAMVERYTSTVKADGGQVHRFEDWGRRQLAYSINKVHKAHYVLLNVECSDAALEELTTNFRYNDAVLRSLVIREDAAITEESFILKAEKEGRERKARPARAERRDDTEAEDLSDEEGVEAEDFEEEQGV
What is the function of this protein?
Binds together with S18 to 16S ribosomal RNA.
What are the official names of this protein?
30S ribosomal protein S6.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS6 family.
Protein: PNP_ALIF1
Sequence: MFANPVVKSFQYGNHTVTLETGVIARQATAAVMASMDDTSVFVSVVAKKEAVPGQDFFPLTVNYQERTYAAGKIPGGFFKREGRPSEAETLTARLIDRPIRPLFPDAFKNEVQVIATVVSINPEVNPDMITMIGTSAALAIAGIPFNGPIGAARVGHINGELVLNPSNTELENSKLDLVVSGTEGAVLMVESEADNLTEEEMLSAVVFGHEQQQVVINAINEFAAEVATPAWDWVAPEENTVLNARIAELAEAKLVEAYQITEKMTRYDRIHEIAAEVNEVLVSENEDVNLKEVHTIFHDLEKTVVRRSIIAGNPRIDGREKDMVRALDVRTGVLPRTHGSSLFTRGETQALVTATLGTQRDAQIIDSLMGEKKDHFLLHYNFPPYCVGETGFVGSPKRREIGHGKLAKRGIQAVMPSIEEFPYTVRVVSEITESNGSSSMASVCGTSLALMDAGVPIKASVAGIAMGLVKEGDDFVVLSDILGDEDHLGDMDFKVAGTNEGITALQMDIKIEGITKEIMQIALNQAQGARKHILKVMDEAISGAREEISEFAPRIHTMKISSDKIKDVIGKGGAVIRALCEETGTTIEIEDDGTIKIAATEGAAAKEAIRRIEEITAEVEVGKIYTGKVMRIVDFGAFVTVLGPKEGLVHISQIAEERIEKVADHLQVGQEVKTKVLEIDRQGRIRLSIKEANAELNPAPAAEAKDAE
What is the function of this protein?
Involved in mRNA degradation.  Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
What are the official names of this protein?
Polyribonucleotide nucleotidyltransferase, Polynucleotide phosphorylase, PNPase.
What is the protein family that this protein belongs to?
Belongs to the polyribonucleotide nucleotidyltransferase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NTPP_MYCPA
Sequence: MTRLVLASASAGRLKVLRQAGVDPLVVVSGVDEDAVIAALGPDASPSAVVCALATAKADRVAGALQAGVAADCVVVGCDSMLFIDGGLCGKPGSADAALRQWRRIGGRSGGLYTGHCLLRLRDGDITHREVESACTTVHFASPVEADLRAYVAGGEPLAVAGGFTLDGLGGWFVDGIDGDPSNVIGVSLPLLRTLLTRVGLSVSALWAAD
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RLMN_FRAP2
Sequence: MQQDKINLLGLNQKAIEDFFISIGEKKFHARQVFKWIHKKGVIDFDSMTDLGKNLRNKLKENAEIVIPKVVFNKASKDGTHKWLIDVGGSAVETVFIPEEGRGTLCVSSQVGCTLNCSFCSTGKQGFNRNLSSAEVISQLWIAARTLSKNNGEHDFSVTNIVMMGMGEPLMNFENVVPAMDIMMDDLAYGLSRRKVTLSTSGVVPRIYDLLEQSGVSLAVSLHAPTDSLRNEIVPINKKYNIDELLEACKLYAEKGPHKHITFEYTLMEEVNDNLSDAEQLIELLRSREVPAKINLIPFNPYPGTPYRKPSNNRIHRFKEFLQHNGFVTTVRKTRGDDIDAACGQLAGDVMDKTKRKERYLKKLGDKNAI
What is the function of this protein?
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.  m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
What are the official names of this protein?
Dual-specificity RNA methyltransferase RlmN, 23S rRNA (adenine(2503)-C(2))-methyltransferase, 23S rRNA m2A2503 methyltransferase, Ribosomal RNA large subunit methyltransferase N, tRNA (adenine(37)-C(2))-methyltransferase, tRNA m2A37 methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. RlmN family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: METK_JANSC
Sequence: MARNNYLFTSESVSEGHPDKVCDRISDAILDAFLSEEPEARVACETFATTNRVVIGGEVGLSDQDKLAEYMGQVDPIVRACVKDIGYEQDKFHHETVEITNLLHEQSAHIAQGVDAAENKDEGAGDQGIMFGFAVAETPELMPAPIHYAHAILKKLAEVRKSGEQAVLGPDAKSQLSVRYEDGTPVGVSSIVLSTQHLDESLTSDDVRAIVEPYIRGELPDGWISAETEWHVNPTGKFVIGGPDGDAGLTGRKIIVDTYGGAAPHGGGAFSGKDPTKVDRSAAYASRYLAKNVVAAGLAHRCTIQLSYAIGVAKPLSIYCDTHQTGQVHEAEIERALGQVMDLTPRGIRTHLGMNRPIYERTAAYGHFGRAAEADGGFSWEKTDLADAIKAAL
What is the function of this protein?
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP.  The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
What are the official names of this protein?
S-adenosylmethionine synthase, AdoMet synthase, MAT, Methionine adenosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the AdoMet synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PSB28_GLOVI
Sequence: MAVAQFLEGINEEITDIRVMASKYDTSRKTALIYIAAPKADLNQVMSFRMRDEEGEITVRDIRSKHLNGKFIGLEISHEMGSDAAWNRFYRFMERMGYA
What are the official names of this protein?
Photosystem II reaction center Psb28 protein, Photosystem II 13 kDa protein, Photosystem II reaction center W protein.
What is the protein family that this protein belongs to?
Belongs to the Psb28 family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Protein: SPEE_NEIMB
Sequence: MARHPYRRLRPAKSGFPEVGISEEGNIRSLHLGSDTVQSSMNLDHPSELVLSYSRAMMGWLLFTDALPQHITQIGLGGGSFARWIDTYLPDTRQTAVDINPQVIAIARNLFELPFEGEKFEIIEADGAEYIKVFRHNTDVILVDGFDGEQIIDALVEEPFFRDCRNALSSDGIFVTNWWSGDKRYQRFIERLLSVFEGRVLELPAESHGNVAVMAFQSSPKEQNIDKLKKRADKLSNAYGLDFHRMLAGLKASNPNNGKHFHL
What is the function of this protein?
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
What are the official names of this protein?
Polyamine aminopropyltransferase, Putrescine aminopropyltransferase, PAPT, Spermidine synthase, SPDS, SPDSY.
What is the protein family that this protein belongs to?
Belongs to the spermidine/spermine synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y006_RICPR
Sequence: MVAATGHRICNDCSKACIYQKQDPVNIPLIESNILEETLKLPYGLEIYILLTRWNPLNIYAPLPKEPTNYNILVTGLGPAGFSLSYYLLRSGHNVTAIDGLKITPLSFNIHKPVKFWHEYKNLLSERIPKGFGGVAEYGITIRWDKNNLDILRLILERNNNFKYYDGVALGFNITKEQALDLSFDHVAFCIGAGKPKILNIENFEAKGVRTASDFLMTLQNGGAFLQNSNTNMMIRMPIVIIGGGLTSLDVATESLFYYKKQVEEFAKNYIEKDLTEEDKEIAEEFIAHAKLFKEAKNNEELKKVFNKLGGATVYYRGRLQDSPAYKLNHEELIYTLALGVNFKENMQPLRINIDKYGHVESVEFSITTWLDRRTHKKYHINMCPTVKPSSNTVLIKTKTVIMAIGIENNTQFDYDKYSYFGDCNPKYFGSVVKAITSAKEGYEVINKRLIDNVPSFKGSYACFITQLDYLLTSRINKINILNDKTFELIIHSPLAAKNFQFGQFFRLQNYSKDITKLIEPVALSPADIDIEKGLISFIVYEVGKSTSLCKTLSENEKVVLMGPTGSPLEIPQNKKIIIIDSKYRNVGLLKILKENKNKVIFATYPDIKKHKLTSVDIVIINTSPEIAEELQELKIFGENTELIINVNSLMQCMMKGICGQCIQKVKGKQKYIFACSEQNQNVEIIDFKSLKTRLRQNSLQEKMSN
What are the official names of this protein?
Uncharacterized protein RP006.
Protein: RS3_NOVAD
Sequence: MGHKSNPIGLRLQINRTWDSRWYAEGRNYAQMLEEDLKIRKYIVENLPQAAISKVVIERPAKLCRVSIYAARPGVIIGKKGADIEKLRSKLATMTGSDVKLNIVEIRKPEIDSKLVAQGVADQLVRRVAFRRAMKRAVQSALRLGAEGIKITCGGRLGGAEIARVEWYREGRVPLHTLRANIDYAEAEAHTAYGVIGIKVWIFKGEILGHDPMAQDRLMMEAQTSGVRPAR
What is the function of this protein?
Binds the lower part of the 30S subunit head.  Binds mRNA in the 70S ribosome, positioning it for translation.
What are the official names of this protein?
30S ribosomal protein S3.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uS3 family.
Protein: CH60_SALHS
Sequence: MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQSIITEGLKAVAAGMNPMDLKRGIDKAVAAAVEELKALSVPCSDSKAIAQVGTISANSDETVGKLIAEAMDKVGKEGVITVEDGTGLQDELDVVEGMQFDRGYLSPYFINKPETGAVELESPFILLADKKISNIREMLPVLEAVAKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIATLTGGTVISEEIGMELEKATLEDLGQAKRVVINKDTTTIIDGVGEEAAIQGRVAQIRQQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALIRVASKIADLKGQNEDQNVGIKVALRAMEAPLRQIVLNCGEEPSVVANTVKGGDGNYGYNAATEEYGNMIDMGILDPTKVTRSALQYAASVAGLMITTECMVTDLPKSDAPDLGAAGGMGGMGGMGGMM
What is the function of this protein?
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding.  The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
What are the official names of this protein?
Chaperonin GroEL, 60 kDa chaperonin, Chaperonin-60, Cpn60.
What is the protein family that this protein belongs to?
Belongs to the chaperonin (HSP60) family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: IFGC_PENRF
Sequence: MMFHFLGTAGLGIALSWLVFTHFLQSSCRCQPWEPCWPSDEQWELLNRSMEFTLVRLQPIASVCYNHSLDHTLCEDVMRMSRDSGWRASQPGALQDWVWESGQSPGDACPLGSQMNGHTQCHQGRIPLYSAMVNSTKHVQEAVMFAKRHDLRLIIRNTGHDLAGRSSSPNALQIHTHRLQDIKFHDNVQLHGFEKSFGPAVSVGAGVMMGDLYARSAQNGYIVVGGDCPTVGVVGGFLQGGGISDFLSLHHGLAVDNVLEFEVVTASVSLPEPDAIQYCGFLTLRQGDIVLANAIRNPDLFWALRGGGGGTFGIVTRATMRVFPDVPAIAAELGVQTSQSHGEYSRSLAAFFTVLQSLNRENVGGQLIITVISEHSIEAKLKMFFLNQTNTADVDQRMQPFVEDMRRIETHVTYESTSLPKLSMNYRQVPDIHTDNDYGVLGSTVAISNDLFNASKGPAYVADGLAQLPTRPGDLLFTSNLGGQVMRNGDLMETSMHPAWRNATQLINFVRPVEPTIEGKAGALQNLTNIHMPLLYAIDPRFRLSYRNVGDPNEKDFQQVYWGQSYARLLQLKRRWDREGLLISKLGVGSEEWDSEGMCRTGRRSLENLAIDTLSSLAHLIHVTYRCIW
What is the function of this protein?
FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids (PubMed:28620689).  The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan (PubMed:28620689).  The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan (PubMed:28620689).  The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde (PubMed:28902217).  The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline (PubMed:28620689, PubMed:28902217).  The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine (PubMed:28620689).  Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A (PubMed:28620689).  Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 (PubMed:28620689, PubMed:28902217).  The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions (PubMed:28902217).
What are the official names of this protein?
FAD-linked oxidoreductase ifgC, Isofumigaclavine biosynthesis cluster A protein C.
What is the protein family that this protein belongs to?
Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
Protein: Y1770_RHOPA
Sequence: MSLITNAKLYPPRHPRAVHLAHHLAAIAPGVLVTAAIAAAAVGLRAIPGMPGISPMLLAILIGIVAHNGIGTPSWAVPGVKFSLRRVLRFAIILLGLQLTTAQLIEVGGEGLAIIAATLLATFCFTVWFGRVLGVDRKLTELIAAGTSICGASAIIATNTVTRADDEDVAYGVACVTVFGSLAMVSYPLLQSVLNLDAHGFGLWTGASIHEIAQAVAVSFQGGQRAGEFGTIAKLSRVMMLAPLVIGLGMLARVRAKHQPAGDHTATPPMPWFVLGFVAMIGVNEFVAIPHEAKSWIVAITAFLLSMALAAMGLETDLRKLAARGLRPALLGLTASLFIAGFSLALIKLTGWHG
What are the official names of this protein?
UPF0324 membrane protein RPA1770.
What is the protein family that this protein belongs to?
Belongs to the UPF0324 family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: Y775_PROMT
Sequence: MEYLTHSLIAKSEARQIVNKLKAEKLSWQDGKKTAGSHASEKKSNFQLDKNSKLSIKLRDIIVNKIISNPLLKSFTLPSLIHGVMFTQSLAGHHYGSHIDNPYMPSGRSDLSFTLFLNAPEDYEGGELCIQTINKTEKIKLSAGEMIIYPSTQLHSVAEVKDGERHVCVGWIQSYVQNNEDRNFLFGLDAGAKGLLAKHGRSDELDLIFQAYSNILRRLGD
What are the official names of this protein?
PKHD-type hydroxylase PMN2A_0775.
Protein: Y843_HAEIN
Sequence: MVPLCEGDLWQELSLLAAGCRFPHLDEMVNIASINGRKVLGLELI
What are the official names of this protein?
Uncharacterized protein HI_0843.
Protein: RPIA_ENTFA
Sequence: MNLKQMVGIEAAKYVEDGMIVGLGTGSTAKFMVDEIGRRVKEEGLSIVGVTTSKETEKQALALGIPLKSIDEVPYVDLTIDGADEISADFQGIKGGGAALLFEKIVATYSKKCIWIVDKSKMVDDLGAFPLPVEVVPYGSRQLVHLFEEKGYHPTLRLNAAGETLITDGGHHIIDLHLEKITDPEALGSYLDNLVGVVEHGLFLNMVSMVIVGYEDGPKTLHVPAR
What is the function of this protein?
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
What are the official names of this protein?
Ribose-5-phosphate isomerase A, Phosphoriboisomerase A, PRI.
What is the protein family that this protein belongs to?
Belongs to the ribose 5-phosphate isomerase family.
Protein: MTAP_DANRE
Sequence: MTSNSHVKIGIIGGSGLDDPDILEGRTERYVVTPYGKPSDALILGKIKNVDCVLLARHGRQHTIMPTNVNYQANIWALKEEGCTHLLVTTACGSLREDIQPGDIVLIDQFIDRTTKRVQTFYDGQPTSPPGVCHIPMAEPFCSKTREVLLEVAQGLGVKCHTRGTMVTIEGPRFSSRAESLMFRQWGADVINMTTVPEVVLAKEAGLCYASIAMATDYDCWKEHEEAVCVDNVLKTMKENANKASSILLTAIPQICQMDWDSTINAHKSMSQSSVMLPKH
What is the function of this protein?
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate.  Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis.  Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine.  Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
What are the official names of this protein?
S-methyl-5'-thioadenosine phosphorylase, 5'-methylthioadenosine phosphorylase, MTA phosphorylase, MTAP, MTAPase.
What is the protein family that this protein belongs to?
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.