PharMolix/UniProtQA huggingface dataset:
Protein: TTCA1_FRATN
Sequence: MTNNTDKQTLKKLERQILRKTAQAINQYNMIEDGDKIMVCLSGGKDSYCLLEMLLLLQKKAPISFEIIAVNLDQKQPGFPEEVLPNYLKNKGVEFHIIQRDTYSVVKRVIPEGKTTCGLCSRMRRGILYDFAEENSVTKVALGHHRDDIIETFFLNLFYNGSIKAMPAKLLSDDKRNIVIRPLAFVSEKETLEYSQLKEFPIIPCNLCGSQDNLQRVFIKDMLNRWEQNNPERKNVIFKALSNISPSQMLDKELFDFINISKDDIQR
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase 1, Two-thiocytidine biosynthesis protein A 1, tRNA 2-thiocytidine biosynthesis protein TtcA 1.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y1216_XYLFM
Sequence: MMRGNIAQLMQQAQKMQENLQRAQEELAKLEVTGSAGGSMVSVILSGTKECRKVRIDPSILNDQEMIEDLIAAAFNDASNKVDAESKERMGSATLGMSLPPGFKLPF
What is the function of this protein?
Binds to DNA and alters its conformation.  May be involved in regulation of gene expression, nucleoid organization and DNA protection.
What are the official names of this protein?
Nucleoid-associated protein Xfasm12_1216.
What is the protein family that this protein belongs to?
Belongs to the YbaB/EbfC family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid.
Protein: PAR1_TRYBB
Sequence: MAPRSLYLLAVLLFSANLFAGVGFAAAAEGPEDKGLTKGGKGKGEKGTKVGADDTNGTDPDPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPGAATLKSVALPFAIAAAALVAAF
What is the function of this protein?
Major surface antigen of procyclic forms.
What are the official names of this protein?
Procyclic form-specific polypeptide B1-alpha, PARP, Procyclin B1-alpha.
What are the subcellular locations of this protein?
Cell membrane; Lipid-anchor, GPI-anchor.
Protein: YJN3_SCHPO
Sequence: MDADDFGKKDLENGNESPKKPIFMKDWKNSQPNEQGRWLHLDARMNRNIEDLEISNYNLRLMNEQLESQLLSLNVKPVVSFAEQGKSSESKTDEEGFILNSASNVLDNFISIVNELVQHAEDVLDDLG
What are the official names of this protein?
Uncharacterized protein C24B10.03.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: DEF_VIBC1
Sequence: MSVLQVLTFPDDRLRTVAKPVEEVTPEIQKIVDDMIETMYDEEGIGLAATQVDIHKRIVVIDISETRDEPMVLINPEILEKRGEDGIEEGCLSVPGARALVPRAAEVTVKALDRDGKEYTFEADDLLAICVQHELDHLMGKLFVDYLSPLKRKRIQDKLAKIKRFNEKQQNA
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: KDPC_SALA4
Sequence: MIGLRPAFSTMLFLLLLTGGVYPLLTTALGQWWFPWQANGSLIHKDNVIRGSALIGQSFTAAGYFHGRPSATADTPYNPLASGGSNLAASNPELDAQIQARVAALRAANPQASSAVPVELATASASGLDNNLTPGAAAWQIPRVAAARQLPVEQVAQLVAEYTHRPLARFLGQPVVNIVELNLALDALQGHRAK
What is the function of this protein?
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm.  This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
What are the official names of this protein?
Potassium-transporting ATPase KdpC subunit, ATP phosphohydrolase [potassium-transporting] C chain, Potassium-binding and translocating subunit C, Potassium-translocating ATPase C chain.
What is the protein family that this protein belongs to?
Belongs to the KdpC family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: ARGR1_CLOPE
Sequence: MSNLEKSLRHEVILDIIESKCICKQEELIIELKECGINVTQATLSRDLHEMNIIRKSFENHEHRYIVTKEDKFIKKFKNIFKSSVRSISMQEYFISVNTLDGMASLIGEFIDRLGDGRIAGTVAKKNHILVLCRSVNATQQIFKELDSLRV
What is the function of this protein?
Regulates the transcription of the arc operon, involved in arginine catabolism.
What are the official names of this protein?
Arginine regulator.
What is the protein family that this protein belongs to?
Belongs to the ArgR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: Y01G_BPT4
Sequence: MNKDMTLEEAKAKANEAMDLLLKIGSKMMEENEKYIQENKIPDGPLVGKRKSHD
What are the official names of this protein?
Uncharacterized 6.2 kDa protein in modB-mrh intergenic region.
Protein: RNAAM_HAEIN
Sequence: MTKKYDLHCHSTASDGVLSPTELVHRAYAQGVNVLALCDHDTIAGIDEAEIAAKEVGIELITGVEISTNWEGRGIHIVGLNFDKTHPKMTALLQSQKALREKRAVEIGDKLEKAGIPNAYDGAKALADGEVTRAHYARYLVQIGKVSNDGQAFKRYLGQGKSAFVKAEWADIPTAIETIHAAGGIAIIAHPLRYNMTGKWVRKLIVDFKAWGGDGMEMADCGQTKDQRQMLARWAKEFDLQGSVGSDFHFPCGWIELGKNLDLVDSVIPVWEKF
What is the function of this protein?
Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base.  Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides.  This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency lower than that of the corresponding single-stranded oligonucleotides.
What are the official names of this protein?
5'-3' exoribonuclease, 3',5'-nucleotide bisphosphate phosphatase, RNase AM.
What is the protein family that this protein belongs to?
Belongs to the PHP family. TrpH/YciV subfamily.
Protein: MUKF_ECOL6
Sequence: MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLNGERLDGEMSEGELVDAFRHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAEEGGDEFHWHRNVYAPLKYSVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDEPWALTYANADRLLDMRDEEMVLRDEEVTGELPEDLEYEEFNEIREQLAAIIEEQLAVYKTRQVPLDLGLVVREYLSQYPRARHFDVARIVIDQAVRLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY
What is the function of this protein?
Involved in chromosome condensation, segregation and cell cycle progression.  May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.  Not required for mini-F plasmid partitioning.  Probably acts via its interaction with MukB and MukE.  Overexpression results in anucleate cells.  It has a calcium binding activity.
What are the official names of this protein?
Chromosome partition protein MukF.
What is the protein family that this protein belongs to?
Belongs to the MukF family.
What are the subcellular locations of this protein?
Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Protein: RUVA_CAMHC
Sequence: MIVAVEGIITKKEPTFCVLKTVTGVSYGISISLGCSARINKGEKIELLTAQILREDADLLYGFLDEKEKRMFEMLIKLNGIGANTAMAVCSSLSSDNFLRAIINGDTATLTTVPGIGPKTARRIIAELSDAKIELANDGEQYKIETISALENLGFKRDKINKILLNCKSTNTADLIKEALKKLA
What is the function of this protein?
The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR).  RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure.  The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex.  HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.
What are the official names of this protein?
Holliday junction branch migration complex subunit RuvA.
What is the protein family that this protein belongs to?
Belongs to the RuvA family.
Protein: MACB_HYPNA
Sequence: MTPPLIELKDVTRYYGSGDTEVRALDGVSLTIETGEFVAIVGQSGSGKSTLMNLLGCLDRPTNGRYAIRGQNVSELDPDNLAALRRETFGFIFQRYNLLASVSASENVEIPAVYAGLALSERREKAAGLLAKLGLGERVHHKPGQLSGGQQQRVAVARALVNDAEVILADEPTGALDSGSSNDLLNLLEELHASGRTIILITHDQKVAARAKRVIEIRDGKIISDSGNKQAAAEEAPQYRYARKGPSPIAQVAESVKMAFRSLRANLFRTALTLLGVVIGVSAVVAMLAIGEGSRAEVMARFESMGPNLLFVRPGAPGTRMRGGAIATLTLEDAQALGELENILAAVPSRSTNATLRNGGNDYSSSIEGVSETWPIAQNRDMLYGTFFTKDDVDRRIGAVVLGTTTAGNLFDDIESAVGQYVFLGGAPFEVAGILESKGASSWGQDQDDIALVPITTGMMRLFGQSYLSSITLAVDDTDRITETEAAAHAFLLARHGTEDFQIRNTASILASVEETQNSFSILLGSVAAISLLVGGIGVMNIMLVSVSERTREIGVRMATGARRSDIQTQFIVESLVVGGLGGIAGVAIGFGIVFIIAQMGMTVAVTPLPAILAFSSALGTGLVFGLLPARQASRLDPVAALASE
What is the function of this protein?
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation.  Confers resistance against macrolides.
What are the official names of this protein?
Macrolide export ATP-binding/permease protein MacB.
What is the protein family that this protein belongs to?
Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: DEF_BRADU
Sequence: MALREIIILPDKQLRLVSKPIEKVTTEIRKLADDMFETMYDAPGIGLAAIQIAQPLRLITMDLAKRDENGETKPEPRVFINPEVIASSEELSVYEEGCLSIPEYYEEVERPAKVRVRFTDLDGKVHEEDAEGLYATCIQHEIDHLNGVLFVDYLSKLKRDRVLKKFEKAAKRAE
What is the function of this protein?
Removes the formyl group from the N-terminal Met of newly synthesized proteins.  Requires at least a dipeptide for an efficient rate of reaction.  N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
What are the official names of this protein?
Peptide deformylase, PDF, Polypeptide deformylase.
What is the protein family that this protein belongs to?
Belongs to the polypeptide deformylase family.
Protein: BPHR_PARXL
Sequence: MNARTPNSLTMGGDKSFADASPVPIANVRSLIEATFQRLRADIVEGRLAAGSRLAIEDLKSRYEVSGGTVREALSLLVANNLVQTQAQRGFHVTPMSLDDMRDLAATRIALECEALRQSVLNGDAEWEARVVSSYHRLSLLDERTMRDPVHLFNQWEQANRDFHEALISACSSAWTQRFLSILYLQMERYRRLTAMHNRPARNVHEEHLALRDSALARDAERCTELLRMHIESSISVVRQFGLLR
What are the official names of this protein?
Uncharacterized HTH-type transcriptional regulator BphR.
Protein: SYFA_BRASO
Sequence: MSDLASLETSILDQIAAAGDEAALEAVRVAALGKKGSISALLATLGKMSPDERKTQGAAINLAKDKVTQALSARRDVLKAAALDARLAAETIDVTLPLQDTPADTGRIHPLSQVMDELTTIFADMGFSIAEGPDVETDDYNFTKLNFPEGHPAREMHDTFFFNPKEDGSRMLLRTHTSPVQVRTMLSQKPPIRVICPGRTYRIDSDATHTPQFHQVEGLVIDKGSHLGHLKWILHEFCKAFFEVDHINMKFRPSFFPFTEPSLEVDIQCRRDKGEIRFGEGEDWLEILGCGMVHPNVLRACGIDPDEYQGFAWGMGIDRIAMLKYGMSDLRQLFEGDVRWLSHYGFKPLEVPTLAGGLST
What are the official names of this protein?
Phenylalanine--tRNA ligase alpha subunit, Phenylalanyl-tRNA synthetase alpha subunit, PheRS.
What is the protein family that this protein belongs to?
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DEF46_ARATH
Sequence: MGSTKTLVTCFLTIILAVSLSNHNVLAIDAGIKGFDTDHCDTRCYGRDECMNYCIKAGFPKGGQCGSLCIPCGFKCCCQK
What are the official names of this protein?
Defensin-like protein 46.
What is the protein family that this protein belongs to?
Belongs to the DEFL family.
What are the subcellular locations of this protein?
Secreted.
Protein: DPH2_GIBZE
Sequence: MASELSSAPVLSTPDDHILEVPAADSIPTSTLSDDALRTTYEIVRTADEIRAGGWKRIGLQFPDFMLVDAPRVVEALSKEINTHDQEEAKPERRIYVLADSSYSACCVDEIAAEHVSADVVVHYGRTCLSPTSHLPAIYVYTTHDLDYEVTINEIKKEFSDKTVKLVIMADLTYQNHVDKVVSLLKEQGYNDAVSTEVTRDPAALIPNRKILSDETHDDEHWKAYSIIHISDPPSALLLALYTRFASLHVLSTPSPALENPTMRTAGLLRRRFAKVLALASAGVIGILVNTLSVANYLSSINTLRERIARADKKSYTIVVGKLNPAKLANFAEIEGWVVVGCWESGLIEDDAGYWRPVITPFELEVALMSEEERVWGGEWWGGIEKLGLNDKPEDASKESEGAVAEEEVEFEDVAGGVEGEESAPPEFDMRTGKLISSSRPMRLPVRKNPSTTAETEANSDGQPTSTQQNDSLIKRSVGELASINGVASPGAEFLRSGRTWQGLGTDFDNEASTLVEEGRSGVARGYEVGESGRH
What is the function of this protein?
Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.  DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity).  Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).
What are the official names of this protein?
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, Diphthamide biosynthesis protein 2, Diphtheria toxin resistance protein 2, S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2.
What is the protein family that this protein belongs to?
Belongs to the DPH1/DPH2 family. DPH2 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL2_FRATF
Sequence: MIEIKKAKPTSPGRRHVVSVKNTELHTGKPFKGLVEVKKSKAGRNNTGRITVRHQGGGHKQHYRIVDFKRNKDDITAKVERIEYDPNRSANIALVLYADGERRYIVAPKGLKKDMSVISGEKVDIAVGNCMPLRNIPLGTVIHNIEMKPKKGAQMIRSAGTFAQLVGKDNAYAIIRLRSGEMRRVLLDCRAVIGVVSNSEHNLKSLGKAGAKRWRGIRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVTPWGIPTKGYKTRRNKRSNKLIVQKRK
What is the function of this protein?
One of the primary rRNA binding proteins.  Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation.  It has been suggested to have peptidyltransferase activity; this is somewhat controversial.  Makes several contacts with the 16S rRNA in the 70S ribosome.
What are the official names of this protein?
50S ribosomal protein L2.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL2 family.
Protein: YIQ5_YEAST
Sequence: MKNIAYEGRLFLISAVQFMPDATAMGFGEIIDQATGKRKLPGWPSADDNCINGGSVIIDPYGEIIAGPLLGQEGLLTAEINTDLIAEARFDLDPVGHYARGDVFQLTVNERSHDVKFTK
What are the official names of this protein?
Putative nitrilase-like protein YIL165C.
What is the protein family that this protein belongs to?
Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
Protein: FUMC_COREF
Sequence: MSDFMTEQEFRIEHDTMGEVKVPAQALWRAQTQRAVENFPISGRGLESAQIRAMGLLKAACAQVNKDSGALDAAKADAIIAAGKEIATGKHDAEFPIDVFQTGSGTSSNMNTNEVIASIAKANGTEVHPNDDVNMGQSSNDTFPTATHVAATEAAVNDLIPGLKVLHESLAKKANEWDSVVKSGRTHLMDAVPVTLGQEFGGYARQIQLGIERIEATLPRLGELAIGGTAVGTGINTSADFGGKVVAELVELTGVTQLQEAANHFEAQANRDALVEFSGAMRVVAVSLYKIANDIRLMGSGPLTGLGEIQLPDLQPGSSIMPGKVNPVLCETATQVSAQVIGNDAAVAFAGSQGQFELNVFIPVMARNVLESARLLANTARVFATRLVDGIVPNEEHMKQLAESSPSIVTPLNSAIGYEAAAKVAKAALAEGKTIRQTVIDMGFVDGEKLTEEELDKRLDVLAMANTDRKQKF
What is the function of this protein?
Involved in the TCA cycle.  Catalyzes the stereospecific interconversion of fumarate to L-malate.
What are the official names of this protein?
Fumarate hydratase class II, Fumarase C, Aerobic fumarase, Iron-independent fumarase.
What is the protein family that this protein belongs to?
Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ALL2_TYRPU
Sequence: MKFLILFALVAVAAAGQVKFTDCGKKEIASVAVDGCEGDLCVIHKSKPVHVIAEFTANQDTCKIEVKVTGQLNGLEVPIPGIETDGCKVLKCPLKKGTKYTMNYSVNVPSVVPNIKTVVKLLATGEHGVLACGAVNTDVKP
What are the official names of this protein?
Mite group 2 allergen Tyr p 2.
What is the protein family that this protein belongs to?
Belongs to the NPC2 family.
What are the subcellular locations of this protein?
Secreted.
Protein: RL9_PERMH
Sequence: MKVILTKDVEGWGTIGDIIDVKRGFARNYLIPKGFALEATESHIKHVQEILKQKARKLEREKAKAEEIAKQLEGLEIEIKKSVGTTGKLFGSVTTSDIAEVLKEKGIEVEKKKIMLRNPIKNIGSYNITIRLHPQVSATIKVHVTPENI
What is the function of this protein?
Binds to the 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L9.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL9 family.
Protein: OBG_PARMW
Sequence: MQFIDQARITVRGGRGGDGIAAFRREKYVPAGGPSGGDGGHGGPVVLEADSNLQTLLDFKYKRLFAADDGRRGGPNKCTGASGRDLVIKVPCGTEVRHLATGILLGDLTDPGERLTVAFGGRGGLGNAHYLSNRNRAPEKFTEGRDGEEWPLQLELKLLAEVGIIGLPNAGKSTLIAVLSAARPKIADYPFTTLVPNLGVVRRPSGDGTVFADIPGLIAGAAQGAGLGHDFLRHIERTRLLIHVVDAGADDPVGDLRVVEKELEAYGHGLVDRPRLLVLNKQELLLDEQLPELSNELEQVSGRAPLCISAAMGRNLDQLLERVWKELGIA
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HSV2_EMENI
Sequence: MLGQSNYLALVGGGRQPKFPQNKLVIWDDAKQKVVITLEFRTSVLGVRLSKSRIVVALLNSIHTFVFSSPPKKLAVFETTDNPLGLACLGQKVLAFPGRSPGQVQLVELETGNVSIIPAHSTPLRAMALSPDGEVLATASEAGTLVRIFATSNCAKMAELRRGVDHAIIFSLAISPSNNLLAVTSDKSTLHVFNLPHPRNAPYSNQQASSSDDGVNKKWGILGKIPLLPRVFSDVYSFASAHFELGEEEPGPTYAPPLGTVLGRPPKGVIGWSNDNTILVVGSGSDGRWEKFVLRDDEEGKKHCIREGWKKYLGSGS
What is the function of this protein?
Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
What are the official names of this protein?
SVP1-like protein 2.
What is the protein family that this protein belongs to?
Belongs to the WD repeat PROPPIN family.
What are the subcellular locations of this protein?
Vacuole membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Vesicular and vacuolar.
Protein: Y892_PSEP1
Sequence: MLLHIPGLFDADELARICEALERADWADGKVTAGYQSAKAKHNLQLPEGHALAKEIGSALIDRLWKTPRFMSAALPHKVFPPLINCYREGGNFGFHIDNALRQPKGSPERVRTDLSSTLFLSDPESYDGGELVIQDTYGVQQVKLAAGDMVLYPGTSLHKVNPVTRGQRYAAFFWTQSLVRDDSQRTLLFEMDNAIQQLTADVPDHPSLLQLTGTYHNLLRRWAEV
What are the official names of this protein?
PKHD-type hydroxylase Pput_0892.
Protein: TM254_MOUSE
Sequence: MGTATGAGYFQRGSLFWFTVITVSFGYYTWAVFWPQSIPYQSLGPLGPFTKYLVDHYHTFLRNGYWLAWLIHVGESLYALVLCKRKGITDVQAQLLWFLQTFLFGVASLSILIAYRSKRQKHN
What are the official names of this protein?
Transmembrane protein 254.
Protein: AP2A_SCHPO
Sequence: MVASNNMKGLRAFISDLRSLEHDDEEKRVNVELAKIRAKFQSSTLSAYDRKKYVSKLLYIYMLGYPITFGHMEAAKLLSGTKYSEKLIGYLAVALLLNENHELMKLVINSIKKDLLSHDSLQNSLALHTIANIGGRELCETVYYDIYKLLMSASNENIVRQKSALALLHIYRKFPDLINPEWFEPIVMILGDDDLNVSLAVSNFVNLIVIREPKYQKFAYGKAVGKLKNIVFEHGYSSDYLYYSVPCPWLQVNLCRILLACERPSDNPTRATLIRVLDRILSLPNDNSNVQQVNAVNAILFEAIKLAFLVDESHSLYEKCMDRLADMIADKESNIRYLAFETTAYLISCGHSITSLKHYKELILSSLRYKDVSLRKKSLELLYMMCDEENAKLIVADLLQYLPHLDSVTQEDLISKVAIISETFATDYEWYVDVTIQLLRIAGKSADDGVWHQLVHVIVNNEEIQEYATKRLFSLLQSETIHECLVKAGGYVLGEFGHLITDYPDSQPVHQFSTIYRKLNVSSPSTRVLLLTTLIKLANLQPELNDRIAKVFQEYSTIINPEVQQRACEYLQLLKMPRDFLQLVCDEVPPFLDGNRDGVHPKSRPSSKVNLVDTYPQTIPNVSKPSTPIDVPEYDISACLPGFYRLCWKDKGILYQDSQIQIGVRSEYHNSEGAIYLYYENRQSNTLKSLSSTLIRTFSTFHLATTFQDTNLPSGVQLQQKYVMSGVNEIFEPPIIHVSYVTGVIRSIDLQLPVLLSKFMKPTIFDSYDFFNHWGQMGVEREAQLTFGLNSKDRKLDAKRLTKIVSGFHWGICQNVDSIALNIVGAGIIRFGTQNVGCLLRIEPNYEQNLIRLSIRSTNTSIANTLAKEMQEILRNSF
What is the function of this protein?
Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles.  Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.  Alpha adaptin is a subunit of the plasma membrane adaptor (By similarity).
What are the official names of this protein?
AP-2 complex subunit alpha, Alpha-adaptin, Clathrin assembly protein complex 2 alpha large chain, Clathrin assembly protein large alpha chain.
What is the protein family that this protein belongs to?
Belongs to the adaptor complexes large subunit family.
What are the subcellular locations of this protein?
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Protein: VE4_HPV47
Sequence: MADSKAPHHQGHQEDKQTQTPPPRPPPPPQPPLTPRPDANPSINSHNKPKPNEEGTDGDHQAEQGDRKRTKGDPDPDPGRGPVLKPTLPPPPPPPPTGPGLRRSTRLVLVPGQGPPPDLPAPPVEGEVEGHPQGKDRDHPPPTPQNGHGKETQGAEGGGDKGEQGAVGGESSDGEGDHSQPPLTPPNESDGSLLNTVACLLARWESNFDQLVQNIQGDLEGYWRKLGTPQ
What is the function of this protein?
Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions.  Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes.  Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin.  Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity.  Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism.  Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
What are the official names of this protein?
Protein E4.
What is the protein family that this protein belongs to?
Belongs to the papillomaviridae E4 protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host nucleus.
Protein: JJJ2_VANPO
Sequence: MKIDETTYYSVLGLPTTANKKDIHKSYLRLARKLHPDKSKSNDFEELFKVVVQAHSILTDISSKQEYDAILKRKGLSNYTPLGYKEHTKKQNQSNNLNQQDASKNSKKNDGVPTQSKVTRKNKPYEQQPYGFGLDFNEGSKMKKDKQKGRNTSKNSKEQQGSQETTNTSENLQRNAKGNKNNKNPRKDRFHTLDNSLDTENDNKRRNIKKAKDRTSKDQNTYSHTNYQRKRNKVKFTQGSIRMRNPEATQSNPDLQNDWDPLKDIISQFGNSNIQDDFGIENIKPSSDPRTFELEDLSLDCEYDFVESNSRVRRANMQNVFINEMDRLMINDPLDMSSIKHSLYSIPYTKRQKTSQSTYTFNDQNYRFTERLPRQENSEGPFGEIPSVFESSTGTMENHRSDFNLRGRPETRENDNIIIPEMMHFPDAVTSKEEEVSLKTRFNHFNEDCNRTKEYILKVLKNRISVDKDLSDMMTVPEYHSLILATKSFDVHLSKQLLELNELQFNAGQRYTELFKSIQY
What are the official names of this protein?
J protein JJJ2.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: AAAS_HUMAN
Sequence: MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGRLDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRWASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPERCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPRVQDGKPVILLFRTRNSPVFELLPCGIIQGEPGAQPQLITFHPSFNKGALLSVGWSTGRIAHIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSAPWDPLPGPPPVLPHSPHSHL
What is the function of this protein?
Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285).  Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606).
What are the official names of this protein?
Aladin, Adracalin.
What are the subcellular locations of this protein?
Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Note=In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate (PubMed:26246606). The localization to the spindle is microtubule- mediated (PubMed:26246606).
Protein: RL13_AGRRK
Sequence: MATFSQKPAEVEKKWILIDAEGLVVGRLASIIAMRLRGKHKATFTPHVDDGDNVIVINADKIVLTGKKYEDKVYYWHTGYAGGIKERTARQIIEGRFPERVVEKAVERMVPRGPLGRRQMKNLRVYAGSNHPHEAQQPVVLDVAKLNKKNVRSA
What is the function of this protein?
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself.  It is important during the early stages of 50S assembly.
What are the official names of this protein?
50S ribosomal protein L13.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL13 family.