PharMolix/UniProtQA huggingface dataset:
Protein: IL1B_MACNE
Sequence: MAEVPELASEMMAYYSGNEDDLFFEVDGPKQMKCSFQDLDLCPLDGGIQLQISHEHYNKGFRQAVSVVVAMEKLRKMLVPCPQIFQDNDLSTLIPFIFEEEPVFLDTRNNDACVHDAPVRSLHCTLRDAQLKSLVMSGPYELKALHLQGQDLEQQVVFFMSFVQGEESNDKIPVALGLKAKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTRGGQDITDFTMQFVSS
What is the function of this protein?
Potent pro-inflammatory cytokine.  Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.  Promotes Th17 differentiation of T-cells.  Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.  Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6.  Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
What are the official names of this protein?
Interleukin-1 beta, IL-1 beta.
What is the protein family that this protein belongs to?
Belongs to the IL-1 family.
What are the subcellular locations of this protein?
Cytoplasm, cytosol. Secreted. Lysosome. Secreted, extracellular exosome. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10.
Protein: XPOT_MOUSE
Sequence: MDEQALLGLNPNADSDFRQRALAYFEQLKISPDAWQVCAEALAQKTYSDDHVKFFCFQVLEHQVKYKYSELSTAQQQLIRETLLSWLQAQMQNPQPEKTFIRNKAAQVFALLFVTEYLTKWPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVHTSEASGLENTLIKDTMREQCIPNLVESWYQILHNYQYTNSEVLCQCLEVVGAYVSWIDLSLIANDRFINMLLGHMSVEVLREEACDCLFEIVNKGMDPVDKMKLVESLCQVLQTAGFFSIDQEEDLDFVARFSKLVNGMGQSLIVSWTKLIKNGAVKNAQEALEAIETKVPLMLQLLVHEDDDISSNIIGFCYDYLHILKQLPVLSDQQKANVEAIMLAVMKKLTYDEEYNFENEGEDEAMFVEYRKQLKLLLDRLAQVSPELVLASVRRVFSATLQNWQTTRFMEVEVAVRLLYMLAEALPVSHGAHFSGDVSKASALQDMMRTLVTSGVSSYQHTSVTLEFFETVVRYEKFFTVEPQHIPCVLMAFLDHRGLWHSSAKVRSRTAYLFSRFVKSLNKQMNPYIEEILNRIQDLLALSPPENGYQSLLSSDDQLFIYETAGALIVNSEYPAENKQALMKDLLTPLMERFKVLLEKLMMAQDEERQASLADSLNHAVGFASRTSKAFSNKQTVKQCGCSQVYLDCLQTFLPALSCPLQKDVLRSGVRTFLHRMIICLEEEVLPFIPSASEHMLKDCEAKDLQEFIPLINQITAKFKMQVSPFLQQMFMPLLHAIFEVLLRPAEDNDQSAALEKQMLRRSYFAFLQTVTGSGMSEVIANQGAENVEQVLVTIIQGAVDYPDPIAQKTCFIILSKLVELWGGKDGPVGFADFVYKHIVPACFLAPLKQTFDLADAQTVLALSECAVTLKTIHLKRGPECVQYLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYLKVFFQRAKP
What is the function of this protein?
Mediates the nuclear export of aminoacylated tRNAs.  In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form.  Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins.  Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor.  XPOT then return to the nuclear compartment and mediate another round of transport.  The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
What are the official names of this protein?
Exportin-T, Exportin(tRNA), tRNA exportin.
What is the protein family that this protein belongs to?
Belongs to the exportin family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm (By similarity).
Protein: FABZ_AGRFC
Sequence: MADETKATLGTADILEVMKLLPHRYPFLLIDKIIEIDGDSSAIGIKNVTVNEPHFTGHFPDRPIMPGVLIVEAMAQTAGAICARNQGEGGHLVYFMTIDNARFRRPVVPGDRLEIHVVKQRQRGNVFKFHCEAKVEGALVAEADVGAMMIPEGQ
What is the function of this protein?
Involved in unsaturated fatty acids biosynthesis.  Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
What are the official names of this protein?
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase, (3R)-hydroxymyristoyl-ACP dehydrase, Beta-hydroxyacyl-ACP dehydratase.
What is the protein family that this protein belongs to?
Belongs to the thioester dehydratase family. FabZ subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNHA2_STAAR
Sequence: MSLVYLLIAILVIMAMILLTSKRRAMAKYAGYIALTAPVIASIYFLLQVPSVIKQHYLSVSIPWMTSLDINVDLRLDGLSLMFSLIISLIGIAVFFYATQYLSSRKDNLPRFYLYLTLFMFSMLGIVLADNTILMYVFWELTSVSSFLLISYWYNNGDSQFGAMQSFMITVFGGLALLVGFIMLYIMTGTNNITEILGQADHIKNHALFIPMIIMFLLGAFTKSAQFPFHIWLPRAMAAPTPVSAYLHSATMVKAGIFLLLRFTPLLGLSNMYIYIVTFVGLITMLFGSITALKQWDLKGILAYSTISQLGMIMAMVGIGGGYAQHQQDAIASIYVFVLFAALFHLMNHAIFKCALFMGVGILDHEAGSRDIRILSGMRQLFPKMNLVMMIAALSMAGVPFLNGFLSKEMFLDALTQTGQLSQFSLISMIIIVCMGVIASIFTFTYALYMVKEVFWTKYDSKVFTKKNIHEPWLFSLPSLILMVLVPVIFFVPNIFGKGIIVPALRGVSGGNHQIDPLVPHVSQWHGFNIPLLLTIIIILLGSVLAIKVDWKKVFTGKIRQISVSKGYEMVYRQFEKFTTKRFKRVMQDRLNQYIIMTLGIFMVIIGYGYIRIGLPKVHQLHVSEFGPLEVILAIVTVIIGLSLIFIRQRLTMVILNGVIGFVVTLFFIAMKAPDLALTQLVVETITTILFIVSFSRLPNVPRSKVNKKREIIKISVSLMMALIVVSLIFIAQQADGLASISNFYLRADKLTGGKNIVNAILGDFRALDTLFEGLVLIITGLGIYTLLNYQDRRGQDERE
What are the official names of this protein?
Putative antiporter subunit mnhA2, Mrp complex subunit A2, Putative NADH-ubiquinone oxidoreductase subunit mnhA2.
What is the protein family that this protein belongs to?
Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: WASH1_HUMAN
Sequence: MTPVRMQHSLAGQTYAVPFIQPDLRREEAVQQMADALQYLQKVSGDIFSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPGRLQEYGSIFTGAQDPGLQRRPRHRIQSKHRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIHVPSYLPDLPGIANDLMYSADLGPGIAPSAPGTIPELPTFHTEVAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPSVQGAPREVVDPSGGWATLLESIRQAGGIGKAKLRSMKERKLEKQQQKEQEQVRATSQGGHLMSDLFNKLVMRRKGISGKGPGAGEGPGGAFVRVSDSIPPLPPPQQPQAEEDEDDWES
What is the function of this protein?
Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922874, PubMed:19922875, PubMed:20498093, PubMed:23452853).  Involved in endocytic trafficking of EGF (By similarity).  Involved in transferrin receptor recycling.  Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration (PubMed:22114305).  In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T cell proliferation and effector function.  In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation (By similarity).  Involved in Arp2/3 complex-dependent actin assembly driving Salmonella typhimurium invasion independent of ruffling.  Involved in the exocytosis of MMP14 leading to matrix remodeling during invasive migration and implicating late endosome-to-plasma membrane tubular connections and cooperation with the exocyst complex (PubMed:24344185).  Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity (By similarity).
What are the official names of this protein?
WASH complex subunit 1, CXYorf1-like protein on chromosome 9, Protein FAM39E, WAS protein family homolog 1.
What is the protein family that this protein belongs to?
Belongs to the WASH1 family.
What are the subcellular locations of this protein?
Early endosome membrane. Recycling endosome membrane. Late endosome. Cytoplasmic vesicle, autophagosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2 (PubMed:19922874). Localizes to MMP14-positive late endosomes and transiently to invadipodia (PubMed:24344185). Localized to Salmonella typhimurium entry sites (By similarity).
Protein: ARGP_SHISS
Sequence: MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPTEQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIRLNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVSSKPFAEKYFPNGVTRSALLKAPVVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELASGELIDLTPGLFQRRMLYWHRFAPESRMMRKVTDALLDYGHKVLRQD
What is the function of this protein?
Controls the transcription of genes involved in arginine and lysine metabolism.
What are the official names of this protein?
HTH-type transcriptional regulator ArgP.
What is the protein family that this protein belongs to?
Belongs to the LysR transcriptional regulatory family.
Protein: MGTC_SALPA
Sequence: MEERMLMFPYILNLLAAMLLGALIGAERQWRQRMAGLRTNALVATGAAVFILSSMTTSPDSPGRIAAQIVSGIGFLGAGVIMREGMNVRGLNTAATLWCSAGIGVLCGLGQFKNALAATIIILCANILLREAAQRINQLPVSAEAEKRYILKVTCNKEDESAVRQWLLNIVKEAAICLQGLGSVPAQEQGYKEIRAELVGHADYRKTRELIISRIGDNDNITAIHWCIDSQ
What is the function of this protein?
Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival.  May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity).
What are the official names of this protein?
Protein MgtC.
What is the protein family that this protein belongs to?
Belongs to the MgtC/SapB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RPOC_LACJO
Sequence: MIDVNKFESMQIGLASPNKIRSWSYGEVKKPETINYRTLKPEKDGLFDERIFGPTKDWSCACGKYKGIRYRGIVCDRCGVEVTSAKVRRERMGHIELAAPVSHIWYFKGIPSRMGLVLDISPRALEEVIYFAAYIVIDAGDTDLEDKQLLTEAEYREKKAKFGDRFEAKMGAEAVKELLEQVDIDKEVHELKEELKTATGQKRTRAIRRLDILDAFKNSGNKPSWMVMDCIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPRIIVQNEKRMLQEAVDALIDNGRRGRPVVGPGNRPLKSLSHMLKGKQGRLRQNLLGKRVDYSGRSVIDVSPELKFYQCGVPRPMALELFKPFVMHELVKRGLASNIKNAKRKIDREDDDIWDILEDVIKERPVLLNRAPTLHRLGIQAFEPVLVPGKSIRLHPLACEAYNADFDGDQMAIHVPLSDEAVAESRLLMLAAHHILAPKDGKPIVTPSQDIVLGNYWLTQAERGREGEGMIFDSPAEAAIAYANGDIHYHTRIGLAADSMPEKPWPKGYEHGIFVTTYGKLVFNQIFPKDFYYINDPTQENLTHPVDERYFLQPGEDIHEKLDNMKLGQAFKKGFLSDSIAQIYKDYKVQRTSDFLDDLKELGYTVCTTSGLTIGVEDIPTISDKDDIVAEARKKVDVVSKQYRRGLITDEERHDRVISIWNNCKDIVQNEIAQIIHAPRNPITIMADSGARGNISNFTQLAGMRGLMAAPNGGMMEIPVTSNFREGLSVLEMFMSTHGARKGMTDTALKTANSGYLTRRLVDVAQDVIIREEDCGTDRGLTVHAITEGDEMIEPLFDRLVGRYTSKSVYDPETHEVICPADVLMDEDMAHKIVDAGVTEVTIRSVFTCNTQHGVCKKCYGMNLATGDDVEVGEAVGTVAAQSIGEPGTQLTMRNFHNGGVAGAADITQGLPRVQELFEARNPKGRATISEVTGEVTSIEEDPAEHTRQITVKGQTDTRTYDVPYTASVAVAEGDHVVRGDKLTLGSIDPKELIRVRDALTTEKYILSEIQKAYRMQGVEIADKHVEVMARQMLQKVRILDPGETDILPGELMDIGEFKARNREVIISGGIPATAQSVILGITKAALETNSFLSAASFQETTRVLTDASIRGKNDPLLGLKENVIIGKIIPAGTGMPVYREMEPKVDVPEDEKKKSVYSIADIEKKLAAADAEKDNGSAD
What is the function of this protein?
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
What are the official names of this protein?
DNA-directed RNA polymerase subunit beta', RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'.
What is the protein family that this protein belongs to?
Belongs to the RNA polymerase beta' chain family.
Protein: RNFD_SHESH
Sequence: MAFKIASSPHLSRSFQTSSLMQRVILCALPGVAVQCFFFGWGTVIQALLAMSVALLSEAVVLKLRARNVTDTLRDNSALLTGLLIGIAIPPLAPWWVTVIGTLFAIVIVKQLYGGLGHNIFNPAMAAYVMLLISFPVQMTSWVAPSVIASQPVDFIHSLQMIFTGASSSEINAYKLGFDGISMATPLDTIKTDLAMGLTTTESLSKAIFSDGFGVGWFWVNLAYLAGGLVMLKLKVIRWHITAGILAALFICSGVGYLLNPDTFTGPLLHLFSGATMLAAFFIATDPVTAATSVRGRLVFGALIGILVYIIRTFGGYPDAFAFAILLANLCAPFIDHYMKPRAYGHRSAT
What is the function of this protein?
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
What are the official names of this protein?
Ion-translocating oxidoreductase complex subunit D, Rnf electron transport complex subunit D.
What is the protein family that this protein belongs to?
Belongs to the NqrB/RnfD family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: COX1_PANTR
Sequence: MFTDRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIQFAIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNVLSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSANLEWLYGCPPPYHTFEEPVYMKS
What is the function of this protein?
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.  The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase.  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water.  Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)).  The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
What are the official names of this protein?
Cytochrome c oxidase subunit 1, Cytochrome c oxidase polypeptide I.
What is the protein family that this protein belongs to?
Belongs to the heme-copper respiratory oxidase family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: RA05_ORYSJ
Sequence: MASNKVVFSVLLLAVVSVLAATATMAEYHHQDQVVYTPAPLCQPGMGYPMYPLPRCRALVKRQCVGRGTAAAAEQVRRDCCRQLAAVDDSWCRCEAISHMLGGIYRELGAPDVGHPMSEVFRGCRRGDLERAAASLPAFCNVDIPNGGGGVCYWLARSGY
What is the function of this protein?
Seed storage protein.
What are the official names of this protein?
Seed allergenic protein RA5.
What is the protein family that this protein belongs to?
Belongs to the protease inhibitor I6 (cereal trypsin/alpha-amylase inhibitor) family.
What are the subcellular locations of this protein?
Secreted.
Protein: CML11_ARATH
Sequence: MEEIQQQQQQQQQQQQQQQQQQQQQQELTQEQIMEFKEAFCLFDKDGDGCITADELATVIRSLDQNPTEQELQDMITEIDSDGNGTIEFSEFLNLMANQLQETDADEELKEAFKVFDKDQNGYISASELRHVMINLGEKLTDEEVDQMIKEADLDGDGQVNYDEFVRMMMING
What is the function of this protein?
Potential calcium sensor.
What are the official names of this protein?
Calmodulin-like protein 11.
What is the protein family that this protein belongs to?
Belongs to the calmodulin family.
Protein: GUAAA_HALSA
Sequence: MTHILVVDNHGQFTHLEHRLLRDMDGVTVDLTDNTTPPADIDADGLVLSGGPTMADIGHCREYLTLDVPILGVCLGHQLIADELGGRIEAGDYGGYADVTVSISDADDPLVGSLAPDTRVWASHADEVVAVPDGFTITAESDICGVEAMGDTDRDLYGVQWHPEVAHTEEGEAVFENFVAICE
What is the function of this protein?
Catalyzes the synthesis of GMP from XMP.
What are the official names of this protein?
GMP synthase [glutamine-hydrolyzing] subunit A, Glutamine amidotransferase.
Protein: CDD_YERPP
Sequence: MQARFHTSWAELPASLQFALEPILSAENFPAMLTAEQVKTVKNISGLDDDALAFALLPLATACALTPISHFNVGAIARGKSGNFYFGANMEFRGVPLQQTIHAEQCAVTHAWLRGETNLVAITVNYTPCGHCRQFMNELNSGSELHIHLPGRPPSTLGQYLPDSFGPTDLAITTLLMDPVNHGYTLAETDPLTQAALNAANHSHAPYSQSHSGVALETTNGKIYAGRYAENAAFNPSLPPLQAALILANITGENCASIRRAVLVEGHNAVTSQWDTTLATLNALGCSAVKRVTF
What is the function of this protein?
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
What are the official names of this protein?
Cytidine deaminase, Cytidine aminohydrolase, CDA.
What is the protein family that this protein belongs to?
Belongs to the cytidine and deoxycytidylate deaminase family.
Protein: YJAB_ECOLI
Sequence: MVISIRRSRHEEGEELVAIWCRSVDATHDFLSAEYRTELEDLVRSFLPEAPLWVAVNERDQPVGFMLLSGQHMDALFIDPDVRGCGVGRVLVEHALSMAPELTTNVNEQNEQAVGFYKKVGFKVTGRSEVDDLGKPYPLLNLAYVGA
What is the function of this protein?
N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins (PubMed:30352934).  Binds acetyl-CoA (PubMed:19343803).
What are the official names of this protein?
Peptidyl-lysine N-acetyltransferase YjaB, KAT.
What is the protein family that this protein belongs to?
Belongs to the acetyltransferase family.
Protein: DTD_ACTSZ
Sequence: MIALIQRVTRAQVDVDGKTAGKIGKGLLVLLGVEKEDNQARANKLAEKVLNYRVFGDENDKMNLNVRQAQGELLVVSQFTLVADTGRGLRPSFSNGATPALADELYRYFIRKCREKIQVETGEFAANMQVSLTNDGPVTFWLQS
What is the function of this protein?
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs.  Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS.  Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site.  By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
What are the official names of this protein?
D-aminoacyl-tRNA deacylase, DTD, Gly-tRNA(Ala) deacylase.
What is the protein family that this protein belongs to?
Belongs to the DTD family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RR16_MAIZE
Sequence: MVKLRLKRCGRKQQAIYRIVAIDVRSRREGRDLRKVGFYDPIKNQTCLNVPAILYFLEKGAQPTRTVYDILRKAEFFKDKERTLS
What are the official names of this protein?
30S ribosomal protein S16, chloroplastic.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bS16 family.
What are the subcellular locations of this protein?
Plastid, chloroplast.
Protein: CP2CC_RAT
Sequence: MDPFVVLVLSLSFLLLLYLWRPSPGRGKLPPGPTPLPIFGNFLQIDMKDIRQSISNFSKTYGPVFTLYFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPVFEKATKGLGISFSRGNVWRATRHFTVNTLRSLGMGKRTIEIKVQEEAEWLVMELKKTKGSPCDPKFIIGCAPCNVICSIIFQNRFDYKDKDFLSLIENVNEYIKIVSTPAFQVFNAFPILLDYCPGNHKTHSKHFAAIKSYLLKKIKEHEESLDVSNPRDFIDYFLIQRCQENGNQQMNYTQEHLAILVTNLFIGGTETSSLTLRFALLLLMKYPHITDKVQEEIGQVIGRHRSPCMLDRIHMPYTNAMIHEVQRYIDLAPNGLLHEVTCDTKFRDYFIPKGTAVLTSLTSVLHARKEFPNPEMFDPGHFLDENGNFKKSDYFMPFSAGKRKCVGEGLASMELFLFLTTILQNFKLKSLSDPKDIDINSIRSEFSSIPPTFQLCFIPV
What is the function of this protein?
This P450 is active in 15-beta-hydroxylation of steroid sulfates.
What are the official names of this protein?
Cytochrome P450 2C12, female-specific, CYPIIC12, Cytochrome P450 15-beta, Cytochrome P450-UT-1, Cytochrome P450-UT-I, Cytochrome P450I.
What is the protein family that this protein belongs to?
Belongs to the cytochrome P450 family.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Protein: PUR2_RHOBA
Sequence: MSKYNVLIVGSGGREHALAWKVKQSQHVQNVFVAPGNAGTGMDATNVDLDPADHDAVIQFAKENNVGLVIVGPEAPLVAGLVDALTDAGLRAFGPSKAASELEGSKVFCKNLLRSADIPTADYRTFRSADDASRYIKDRFSEPTDPVNVVVKADGLAAGKGVVVCDTRSEALEAIDRIAARKEFGAAGKELIIEERLTGPEVSVLAITDGETIVTLPPAQDHKPANDGDTGPNTGGMGAYCPAPVLDEETLAKVESSILVPVVHAMKRSRRPFKGVLYAGLMLTPAGPKVLEFNVRFGDPECQPLLMRLKTDLVEVMQAVVDGKLEETGPLEFDPRPAICVVMASEGYPADYEKGHAITGIESADKMENVKVFHAGTQRVDGEVVNTGGRVLGVTAMGDSISAAKLQAYKAVREIRWQGAWCRKDISDKALVTADKA
What are the official names of this protein?
Phosphoribosylamine--glycine ligase, GARS, Glycinamide ribonucleotide synthetase, Phosphoribosylglycinamide synthetase.
What is the protein family that this protein belongs to?
Belongs to the GARS family.
Protein: YL108_MIMIV
Sequence: MTSCADNIHDIICNDPNNIVVASMTCDDYFKKIITVIKKIHNRCYMKFINSQTKNGENTCKFIVTGDNSDNTMNCTRIVMKKKHFKYLRCDEKELFIKINVNDFCKKLDMINSYSEIIFYIKKDNINHLFINIITDKNSNNATRIPLIELNYNNISPLKIVFNDKLSVRSWYFFSIFKQIACSSKTIDIITDKKTILFVYTHGNKIKNIDNNINVNTDITTTNLGTYDLTTLSLISDFYEVYSEINMYFKENGLAFVIPIGFGKIYFLIESKK
What are the official names of this protein?
Uncharacterized protein L108.
Protein: HIS8_ACIET
Sequence: MTTPSAELPALARIRDDVRAMQAYVVADATGYLKMDAMENPFGLPPALQAALGQRLGQLALNRYPGTRQNDLKAALAAYAGEPAGSAVLLGNGSDELISLVALACARAQATVLAPVPGFVMYAMSAQLQGLGFVGVPLTADFELDEAAMLDAIAQHRPAITFLAYPNNPTATLWDEAVVQRIIDAAGAQGGIVVMDEAYQPFASRSWIERMRAQPERNGHVLLMRTLSKFGLAGVRLGYMIGPAALVAEVDKVRPPYNVSVLNTEAALFALEHADVFAAQADELRAARTELLAALRAMPGIERVWDSQANMVLVRVPDAARAYEGMKARKVLVKNVSTMHPLLAGCLRLTVGSSADNAQMLTALQASL
What are the official names of this protein?
Histidinol-phosphate aminotransferase, Imidazole acetol-phosphate transaminase.
What is the protein family that this protein belongs to?
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
Protein: DUT_HAEI8
Sequence: MKKIDVKILDSRIGNEFPLPTYATEGSAGLDLRALIDESFEIQPGETKLIPTGLSIYIADPNLAAVILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSMWNRGNEPFKIEVGDRIAQLVFVPVVQAEFNIVEDFQQTERGEGGFGHSGKQ
What is the function of this protein?
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
What are the official names of this protein?
Deoxyuridine 5'-triphosphate nucleotidohydrolase, dUTPase, dUTP pyrophosphatase.
What is the protein family that this protein belongs to?
Belongs to the dUTPase family.
Protein: COAX_CLOK1
Sequence: MILVLDVGNTNIVLGVYDDRELISVWRLSTDSKRTADEYGVQVIDLFLQSKLKPEDITGSIISSVVPTIMYSLEHMIIKYFQVSPIIVGPGVKTGINVKYDNPREVGADRIVNAVAAHEIYNRSLIIIDFGTATTFCAVTSAGDYLGGAICPGIKISSSALFEMAAKLPRVEIIRPQNIIGKNTVSSMQSGIVYGYIGQVDYIVKKMKMEMMDLGEEEPLVIATGGLAKLINEGTKSIDIIDSVLTLTGLRLIYEKNKE
What is the function of this protein?
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
What are the official names of this protein?
Type III pantothenate kinase, PanK-III, Pantothenic acid kinase.
What is the protein family that this protein belongs to?
Belongs to the type III pantothenate kinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL14_HALMA
Sequence: MEALGADVTQGLEKGSLITCADNTGARELKVISVHGYSGTKNRHPKAGLGDKITVSVTKGTPEMRRQVLEAVVVRQRKPIRRPDGTRVKFEDNAAVIVDENEDPRGTELKGPIAREVAQRFGSVASAATMIV
What is the function of this protein?
Forms part of two intersubunit bridges in the 70S ribosome (By similarity).  Binds to 23S rRNA.
What are the official names of this protein?
50S ribosomal protein L14, Hl27, Hmal14.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL14 family.