PharMolix/UniProtQA huggingface dataset:
Protein: RL6_HYPNA
Sequence: MSRIGKLAIPVPAGATVTVAGQTIKVKGPKGELELVLPEVITPKFDNNELSVNPRADLIQAANDVIEAETAKGKRPPTFAQSLSQDARTQWGTARARAANMVEGVTKGYSKTLELVGVGYRAQMQGVDLKLALGYSHDVIYKAPQGIKIEAPKPTEIIISGADKQAVGQVAAEIKKFRPPEPYKGKGIRLQGEYVRRKEGKKK
What is the function of this protein?
This protein binds to the 23S rRNA, and is important in its secondary structure.  It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
What are the official names of this protein?
50S ribosomal protein L6.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL6 family.
Protein: UAP1_HUMAN
Sequence: MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
What is the function of this protein?
Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc.  Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
What are the official names of this protein?
UDP-N-acetylhexosamine pyrophosphorylase, Antigen X, AGX, Sperm-associated antigen 2.
What is the protein family that this protein belongs to?
Belongs to the UDPGP type 1 family.
Protein: ITB4_RAT
Sequence: MAGLCSSPWVKLLLAVVLSAGLPGNMANRCKKAQVKSCTECIRVDKSCAYCTDELFKERRCNTQADVLAAGCRGESVLVMESSLEITENIQIDTSLHRSQVSPQGLQVRLRPGEERNFVFKVFEPLESPVDLYILMDFSNSMSDDLDNLKQMGQNLAKILRQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTENVEEFWDKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRADSTHLLVFSTESAFHYEADGANVLAGIMNRNDEKCHLDATGAYTQYKTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHKYFPVSSLGVLQEDSSNIVELLEEAFYRIRSNLDIRALDSPRGLRTEVTSDTLQKTETGSFHIKRGEVGTYNVHLRAVEDIDGTHVCQLAKEDQRGNIHLKPSFSDGLRMDASVICDMCACELQKEVQSARCHYRGDFMCGHCVCNEGWSGKTCNCSTGSLSDTQPCLREGEDKPCSGHGECQCGRCVCYGEGRYEGHFCEYDNFQCPRTSGFLCNDRGRCSMGECVCEPGWTGRSCDCPLSNATCIDSNGGICNGLGFCECGRCHCNQRSSLYTDTTCEINYSAIRLGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKKAEEVVEYCSFRDEDDDCTYSYTVEGDGSPGPNSTVLVHKKKDCLPAPSWWLIPLLIFLLLLLVLLLLLCWKYCACCKACLGLLPCCNQGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDTVRWKITNNVQRPGFATHAASISPTELVPYGLSLRLGRLCTENLMKPGTRECDQLRQEVEENLNEVYRQVNGVHKLQQTKFRQQPNAGKKQDHTIVDTVLLAPRSAKQSLLKLTEKQVEQGSFHELKVAPGYYTLTAEQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPVGTATLGRRLVNITIIKEQASGIVSFEQPEYSVSRGDQVARIPVIRHILDNGKSQVSYSTQDNTAHGHRDYVPVEGELLFYPGETWKELQVKLLELQEVDSLLRGRQVRRFQVQLSNPKFGARLGQPNTATVIIGEQDETDRSLINEISASPPLPRGDLGAPQNPNAKAAGSRKIHFNWLPPPGKPMGYRVKYWVQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAHGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQGGEDYENFLMYSDDVLRSPASSQRPSVSDDTEHLVNGRMDFAYPGSANSLHRMTAANVAYGTHLSPHQTHRMLSTSSTLTRDYHSLTRTDHSQSGTLPRDYSTLTSLSSQGLPPIWEDGRSRLPLSWTLGSWSRAQMKGVPASRGSPDSIILAGQSAAPSWGTDSRGAMGVPDTPTRLVFSALGPTSLKVSWQEPQCDRALLGYSVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDILGYLVTCEMAQGGGPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSHSGLFQNPLQSEYSTVTSTHSTTTTEPFLIDGLTLGTQRLEAGGSLTRHVTQEFVSRTLTTSGSLSTHMDQQFFQT
What is the function of this protein?
Integrin alpha-6/beta-4 is a receptor for laminin.  It plays a critical structural role in the hemidesmosome of epithelial cells.  Is required for the regulation of keratinocyte polarity and motility.  ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling.  ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling.  ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.
What are the official names of this protein?
Integrin beta-4, GP150.
What is the protein family that this protein belongs to?
Belongs to the integrin beta chain family.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid- anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes.
Protein: TAL_ACIET
Sequence: MNQLDALKQYTTVVADTGDFKQLAQFQPQDATTNPSLILKAVQKPEYAPLLKDCVTRWHGRAIDELMDRLIVRFGCEILSIIPGRVSTEVDARLSFDTAATVARAERIVELYQAEGLHIDRVLIKIAATWEGIQAARQLEQRGIHTNLTLLFSFAQAVACGQAKVQLISPFVGRIYDWYKKQAGANWDEAAMAGANDPGVQSVRAIYNHYKHFGIGTEVMGASFRNTGQIVALAGCDLLTIAPELLAQLAASDAPVARVLDPEAARRVALQPVQYDEAGFRYALNADAMATEKLAEGIRAFAADAAKLEQLMQAAA
What is the function of this protein?
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
What are the official names of this protein?
Transaldolase.
What is the protein family that this protein belongs to?
Belongs to the transaldolase family. Type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: MNTP_CORGL
Sequence: MPFLQISLLSIGVAADAFACSVVRGTAIQVNLFKRALVLAGIFGVFQAAMPLIGWFIGRFFAGITFIAEIDHWIAFALLGIVGTKMIWDAFQPEDDETIVDDGRVQFRPAIILGLATSIDALAVGMGLAFVEVSILKVALSMGSITFALSLAGAWIGHHGGGKFGKWATILGGIILIGIGANIVYEHLSA
What is the function of this protein?
Probably functions as a manganese efflux pump.
What are the official names of this protein?
Putative manganese efflux pump MntP.
What is the protein family that this protein belongs to?
Belongs to the MntP (TC 9.B.29) family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: GLGA_HYDCU
Sequence: MKILFATSEAHPLIKTGGLADVSGSLPDAYHHLKQKVRMVMPAYGDIWEKVSGVKQLSELSIAACGRQLHVRIHVASAEGIDVPIWLVDIPELFHRPGNPYLALDGKDWWDNGERFAVFSKVVAEIAMNRAGLKWQPDLVQTNDWQTGLVSALLTLEAERPKTVFTIHNMAYAGLFPKSLFEGLGLPWSWWEPHDGIEFYDNMSMLKAGIQMADWVTTVSPTYAKEITFPEYAYGLEGVLIKRLDEGRLVGILNGIDHDVWNPKTDPFIRYHYSVDKGRVAAKKRNKKDMLDFWDLPKAVVDADDPVIGLVGRLVPQKGIDLVLEVLPELIEQTNVRFVIVGTGDSLFEYQLTELAHQYPERLMIYIGYSESLAHKVEAGADLFLMPSRFEPCGLNQLYSLAYGTPPIVHSTGGLSDTVVNATKENLATGQATGFVFYDPSRHALKSTILHALHLFSKKGTWQKLQKNGMRQDFSWTRSAKQYLALFKAMV
What is the function of this protein?
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
What are the official names of this protein?
Glycogen synthase, Starch [bacterial glycogen] synthase.
What is the protein family that this protein belongs to?
Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
Protein: GPX4_MACFU
Sequence: MNLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGVRILAFPCNQFGKQEPGSNEKIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF
What is the function of this protein?
Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity).  Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity).  Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity).  Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity).  The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity).  The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity).  May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity).  Required for normal sperm development and male fertility (By similarity).  Essential for maturation and survival of photoreceptor cells (By similarity).  Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity).  Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity).  Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity).
What are the official names of this protein?
Phospholipid hydroperoxide glutathione peroxidase, PHGPx, Glutathione peroxidase 4, GPx-4, GSHPx-4.
What is the protein family that this protein belongs to?
Belongs to the glutathione peroxidase family.
What are the subcellular locations of this protein?
[Isoform Mitochondrial]: Mitochondrion. SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm.
Protein: NUOK_MYCSJ
Sequence: MNPDNYLYLSALLFTIGAAGVLLRRNVIVVFMCVELMLNAANLAFVAFSRMHGQLDGQVVAFFTMVVAACEVVIGLAIIMTIYRARRSASVDDANLLKH
What is the function of this protein?
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.  The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone.  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
What are the official names of this protein?
NADH-quinone oxidoreductase subunit K, NADH dehydrogenase I subunit K, NDH-1 subunit K.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Cell membrane; Multi-pass membrane protein.
Protein: ALS2_DROME
Sequence: MASAADDSALGGQEERESFTIYHEGRELQLHWRGLPPLQRFPASRICSNAGGELLLLTTDHALYSAKLQANREHMDLQLLRTDVVDMDFCSGSQELFVVLTNGSVQRQATGSGRDVGHPHAWQTLGFDPLELHAEGVRIRRVCCSAQGVVFVGASGETYVMGSCGEVFKAEQQPRHMRLYEEGKELLDLAAGNEHFVMLVAPYNLADDALQLSVASAKEEPEDERASVKSISSGHSERSVAANTRHLLHQGYALLHTQLFTFGASNNGLLGSGDHIRRANVMRLQKLDSMGVCSIAAGLEHTVARTLDGRLYHWGLNNHSQLGEDVSSPMEITITENTAALPIEQNSALEATCGDYHTLLLNASGQIHSLQPAPPMRHLQQSSTYAQTLLQLQLGAAWPRQLRLLMCSGGYTLQNQRQFQRQYHYYLSHLQSQLQLLLKHRQAVQTLEIWQRQSALEPLSALGPLLINWERILCLLVATLHSLEGFYRADFVQPADLLFICHYKEYIDLFDGYTKAYCDVFSVNGFGEAVVAITGLSSPLAELNEESYVTRLFQQPFSIYQLFVQFMELLVRTQSEYGEHRVAWSEFARHSCISQELAVNTKDFWSSNDRNPRIVQFRGRHRRVILTSALVPLKLVTSGISRSSNSFILFSDFLCQVSGNSLYSYPLTTLWVWTEGDSLRLTTPEKSFLVSTRSQEMRKVWLDQLQSSIIASLGKPLGSPVPSYRSTGYEFSREHPKFSRVKACGTWRKGVLHGNCYLEYPDGSVYCGELQHGIIEGFGKMVIPTTGLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFCEGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFEGSFSGDDLTGSGVAVFENDYYYEGELTLLGPNGRGEYYMPSGDACGGSGAMGTGEFDDTCELIGNKMFGQLSGTWDTVRIQAGELVLNRRFPKYPSSLGRQVVDHNRKWRSLFNNFESDLANCTASTSSSGGNQSAGTLRKSSKPTLSTAQIWNCIAVYMSKQRAREGTKPGNYFNNILLSLPLPQKTSSPLAKARTTTSALSKLQTEAASALDFLGFPPRRIQSQEALNSKPGGLQRADSLISMGHNTSRDLDNSSLASFQLDQSLMNSTVNGDESSTFNESFSKLSHNNNNSISKHMNNIDCSITSTTSTTSAVLDQVPSFGMALVLTEQDVTSIRLYLEQAFKDRHHPLYVLNERIANCFHYSYGYWKVKPTPILAKQAMREWESISRRIYRFVRKMFPALPEELCQMEGSREVISHITLLYPLVLSEGIYSTLFVLYANKYSRKDEMYRQNLNLAEKLKDQELVELMGHESFLHNVMLDPKFVESVQTLKELQEKFSPQDMLTVIQRSTQLLTEAYEHAMAANAAQLNADNMIPLTMLTMLRAAVPHLGAELALLDDLTGGPNFQAEMNGMAGYCYTTLKAAYEHVTSRALQKIP
What is the function of this protein?
Has guanine nucleotide exchange factor (GEF) activity towards Rab5.  Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab5 into its active GTP-bound form.
What are the official names of this protein?
Alsin homolog, Amyotrophic lateral sclerosis 2 protein homolog.
Protein: Y3703_CELJU
Sequence: MLKTTLLFVVTALAEIIGCFLPYLWLRKGGSIWLLLPAALSLALFAWLLTLHPTASGRVYAAYGGVYVAVALLWLYWVDGVKLSAYDWAGAAVALLGMAIIAMGWQRS
What are the official names of this protein?
UPF0060 membrane protein CJA_3703.
What is the protein family that this protein belongs to?
Belongs to the UPF0060 family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: RECR_LIMRJ
Sequence: MIQYPEPLAKLIESYTKLPGIGQKTATRLAFYTLSMQEDDVTNFAKSLLSAKRDLHNCSICGNITEDDPCPICRDKTRDHSQILVVEQSQDVMAMERMHEYHGLYHVLHGVISPVAGTGPEDINITSLLKRLKKDDEVKEIIIATNASSDGELTAGYLAKLIKPAGIKVTRLAHGLSVGADIDYADEMTLFKAVQGRTEM
What is the function of this protein?
May play a role in DNA repair.  It seems to be involved in an RecBC-independent recombinational process of DNA repair.  It may act with RecF and RecO.
What are the official names of this protein?
Recombination protein RecR.
What is the protein family that this protein belongs to?
Belongs to the RecR family.
Protein: SYE_LACDB
Sequence: MANKKIRVRYAPSPTGHLHIGNARTALFNYLFARHNKGTLVLRIEDTDTARNVEGGAESQIENLHWLGIDWDEGPDIGGDYGPYKQSERKDIYQKYIDQLLEEGKAYYSFKTEEELEAQREEQRAMGIAPHYVYEYEGMTTDEIKQAQDEARAKGLKPVVRIHIPEGVTYEWDDIVKGHLSFESDTIGGDFVIQKRDGMPTYNFAVVIDDHLMEISHVLRGDDHISNTPKQLCVYEALGWEAPVFGHMTLIINSATGKKLSKRDESVLQFIEQYRELGFLPEAMFNFITLLGWSPVGESEIFSKREFIKQFDPARLSKSPAAFDQKKLDWVNNQYMKTADRDELLDLALHNLQEAGLVEANPAPGKMEWVRQLVNMYANQMSYTKQIVDLSKIFFTEAKYLTDEEVEEIKKDEARPAIEEFKKQLDKLDNFTAKKIMDAIMATRRETGIKGRKLFMPIRIATTRSMVGPGIGEAMELMGKDTVMKHLDLTLKQLSEAGIE
What is the function of this protein?
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
What are the official names of this protein?
Glutamate--tRNA ligase, Glutamyl-tRNA synthetase, GluRS.
What is the protein family that this protein belongs to?
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: P2C04_ORYSJ
Sequence: MGVEVPPEESNRCVRGCCRSAAIPLHLPPSSFSLLSPIAKGSESTVYEARLGGERVAAKKPVLSTSDDLDKFHYQLQLLWWVLPIELDHPGLARLVAAHARPPNYLMFFDFFEPPNLADKIHVEEWNPSVQQVVTIATDLAKALQYLNILGIVHRDIKPANILIDKDFHPHLADFGLAMYQKDIKHVSVENWRSSGKPTGGFHKKNMVGTLIYMAPEILRKDIHTEKSDVYSFAISINELLTGVVPYTDLRAEAQAHTVLEMTYTEQQLTAAIVSQGLRPALALPESGAPPSLLSLIQRCWDSDPQQRPSFKDITEELKIIEKHIAVNSCSLASPANKSQNGNTEVHHYQEALSWLNQGELFAKGNKLDSTVDHWSDIFDQSSKYCPTLSWGSFATCGRRETMEDTHFMLPHMSEEKDLHAFGIFDGHRGSAAAEFSVRAVPGFLKQFNSNTSPTDALTEAFVRTDIAFREELILHQKSKRITQKNWHPGCTAVTALIVRNKLFVANAGDCRAILNRAGEPFPMTRDHVASCPKERERIVKEGTEVKWQIDTWRVGAAALQVTRSIGDDDLKPAVTAQPEVIETILSPDDEFLVMASDGLWDVMSNEDVLSIIKDTVKEPGMCSKRLATEAAARGSKDNITVIVVFLRPVSTAERIY
What are the official names of this protein?
Protein kinase and PP2C-like domain-containing protein.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PP2C family.
Protein: MIS35_CAEEL
Sequence: MSDRHMSSIFPECDHLKQIYDKCFTEFFQKFITPNYRHQYAVNPCERLHDVYKRCVEERLATQRPFEIDLDEIRKEYLNTDDDKLKDRQNNQKTNSENKCSSS
What are the official names of this protein?
Uncharacterized protein mdmh-35, Mitochondrial intermembrane space protein homolog 35.
What is the protein family that this protein belongs to?
Belongs to the TRIAP1/MDM35 family.
Protein: AGO_METJA
Sequence: MVLNKVTYKINAYKIKEEFIPKEVHFYRIKSFVNEAFNFYRFVNFYGGMIINKKDKSFVLPYKVDNKVLKYKDGNNEIPIDIEYIKSLKLEYVKPEIAEKLVRGYLKSVHKIEPELSRIIKNIRKHKVVENIKVESYCEYEVKKHDGDYYLILNFRHTASITKHLWDFVNRDKALLEEYVGKKIIFKPNPKVRYTISLVDAPNPQKIEEIMSHIIKYYKWSEDMVKSTFGEIDYNQPIMYCEEILEPFAPQFCNLVFYMDELDSYILKELQSYWRLSNENKGKIINEIAKKLRFIDNTPKELEFMKFNNTPLLVKDVNKNPTKIYSTNTLFTWIYNQNAKIYLPYDVPEIIRNKNLLTYILIDEEIKDELKAIKDKVNKMFRNYNKIANKTELPKFNYANRWKYFSTDDIRGIIKEIKSEFNDEICFALIIGKEKYKDNDYYEILKKQLFDLKIISQNILWENWRKDDKGYMTNNLLIQIMGKLGIKYFILDSKTPYDYIMGLDTGLGIFGNHRVGGCTVVYDSEGKIRRIQPIETPAPGERLHLPYVIEYLENKANIDMENKNILFLRDGFIQNSERNDLKEISKELNSNIEVISIRKNNKYKVFTSDYRIGSVFGNDGIFLPHKTPFGSNPVKLSTWLRFNCGNEEGLKINESIMQLLYDLTKMNYSALYGEGRYLRIPAPIHYADKFVKALGKNWKIDEELLKHGFLYFI
What is the function of this protein?
A DNA-guided ssDNA endonuclease that may play a role in defense against invading genetic elements.  Uses short ssDNA sequences as guides (gDNA) to bind complementary target strands, resulting in slicing of the target DNA (tDNA) (PubMed:24442234, PubMed:27741323, PubMed:28319081, PubMed:28319084).  Endonucleolytically cleaves tDNA (the gDNA indicates where to cleave); two major and two minor products are seen which correspond to cleavage sites between nucleotides 9/10, 10/11, 13/14, and 14/15 downstream of the target residue base-paired with the 5'-end of the gDNA (PubMed:24442234, PubMed:27741323, PubMed:28319081, PubMed:28319084).  Efficient guide-dependent tDNA cleavage requires a minimal length of 15 bp and is maximal at 19 bp (PubMed:28319081).  Prefers gDNA with 5'-phosphorylated purines and 3'-pyrimidines; changing these bases alters the cleavage activity and patterns (PubMed:28319084).  Also has guide-independent activity on tDNA called 'chopping' (PubMed:28319081).  Probably a first round of guide-independent activity on an invading plasmid or virus would generate guide DNAs for subsequent, more efficient, guide-dependent degradation of invading nucleic acids (PubMed:28319081).  Has no activity on substrate with a mismatch at positions 10 and 11, on ssDNA or RNA, nor on DNA:RNA hybrids (PubMed:24442234).  Digests longer (750 bp) dsDNA as well as circular plasmid and naked genomic DNA, but not chromatin, in a guide DNA-independent manner (PubMed:28319081).  Addition of endogenous histone A3 protects DNA from cleavage, while cleavage is insensitive to methylation (PubMed:28319081).  When plasmid encoding active or mutated protein (Ala-541) is transformed into Sulfolobus acidocaldarius about 25-fold fewer transformants are found with active protein; reduced levels of plasmid are found in wild-type transformed cells.  While S. acidocaldarius grows at a similar temperature to M. jannaschii (70 to 80 degrees Celsius) it has very different histone-like proteins, which presumably do not protect against MjAgo (PubMed:28319081).  Binds ssDNA, dsDNA and DNA-RNA hybrids; binding is most efficient with dsDNA (PubMed:24442234).
What are the official names of this protein?
Protein argonaute, MjAgo.
What is the protein family that this protein belongs to?
Belongs to the argonaute family. Long pAgo subfamily.
Protein: RNH_BUCBP
Sequence: MLKTIKIFSDGSCLGNPGPGGYSFIIQHLEYENISSSGFYLTTNNRMELMGIIVATESLKQPCCITISTDSQYVQKGILYWIKNWKTKGWKTSRKTYVKNVDLWLRLEKSLNLHQVTWKWIKSHSGNKKNEQCDHLARESAKFPTLKDFGYIL
What is the function of this protein?
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
What are the official names of this protein?
Ribonuclease H, RNase H.
What is the protein family that this protein belongs to?
Belongs to the RNase H family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ZIC3_MOUSE
Sequence: MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSPATAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHASQVPTYGGAASAAFNSTRDFLFRQRGSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNNQVHLGLRGELFGRADPYRPVASPRTDPYAASAQFPNYSPMNMNMGVNVAAHHGPGAFFRYMRQPIKQELSCKWIEEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGYESSTPPAIASANSKDTTKTPSAVQTSTSHNPGLPPNFNEWYV
What is the function of this protein?
Acts as transcriptional activator.  Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification.  Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
What are the official names of this protein?
Zinc finger protein ZIC 3, Zinc finger protein of the cerebellum 3.
What is the protein family that this protein belongs to?
Belongs to the GLI C2H2-type zinc-finger protein family.
What are the subcellular locations of this protein?
Nucleus. Cytoplasm. Note=Translocation to the nucleus requires KPNA1 or KPNA6 (By similarity). Localizes in the cytoplasm in presence of MDFIC overexpression.
Protein: TRPD_STAAS
Sequence: MTLLTRIKTETILLESDIKELIDILISPSIGTDIKYELLSSYSEREIQQQELTYIVRSLINTMYPHQPCYEGAMCVCGTGGDKSNSFNISTTVAFVVASAGVKVIKHGNKSITSNSGSTDLLNQMNIQTTTVDDTPNQLNEKDLVFIGATESYPIMKYMQPVRKMIGKPTILNLVGPLINPYHLTYQMVGVFDPTKLKLVAKTIKDLGRKRAIVLHGANGMDEATLSGDNLIYELTEDGEIKNYTLNATDYGLKHAPNSDFKGGSPEENLAISLNILNGKDQSSRRDVVLLNAGLSLYVAEKVDTIAEGIELATTLIDNGEALKKYHQMRGE
What is the function of this protein?
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
What are the official names of this protein?
Anthranilate phosphoribosyltransferase.
What is the protein family that this protein belongs to?
Belongs to the anthranilate phosphoribosyltransferase family.
Protein: GSHAB_LISW6
Sequence: MIKLDMTILDSLKENKALRKLLFSGHFGLEKENIRVTSDGKLALTPHPAIFGPKEDNPYIKTDFSESQIEMITPVTDSIDDVYNWLENLHNIVSLRSKNELLWPSSNPPILPAEKDIPIAEYKTPDSPDRKYREHLAQGYGKKIQLLSGIHYNFSFPEALIDGLYDEISLPNESKRDFKNRLYLKVAKYFMKNRWLLIYLTGASPVYLADFTKTKQEEKLRDGSSALHDGISLRNSNAGYKNKESLYVDYNSFDAYISSISNYIEAGKIESMREFYNPIRLKNAHTDQTVESLAKHGVEYLEIRSIDLNPLEPNGISKEALHFIHLFLIKGLLSEDRELCENNQQLADENENNIALNGLSKPAIKNCDNEEMALADAGLLELDKMNDFIQSLRPEDTYFQAIIEKQKERLLHPEKTIAAQVKEQSATAGFIEFHLNQAKTYMEETEALAYKLIGAEDMELSTQIIWKDAIARGIKVDVLDRAENFLRFQKGDHVEYVKQASKTSKDNYVSVLMMENKVVTKLVLAENNIRVPFGDSFSDQALALEAFSLFKDKQIVVKPKSTNYGWGISIFKNKFTTEDYQEALNIAFSYDSSVIIEEFIPGDEFRFLVINDKVEAVLKRVPANVTGDGIHTVRELVEEKNMDPLRGTDHLKPLEKIRTGPEETLMLSMQKLSWDSIPKANETIYLRENSNVSTGGDSIDYTAEMDDYFKEIAIRATQVLDAKICGVDIIVPRETIDRDKHAIIELNFNPAMHMHCFPYQGEQKKIGDKILDFLFE
What is the function of this protein?
Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.
What are the official names of this protein?
Glutathione biosynthesis bifunctional protein GshAB, Gamma-GCS-GS, GCS-GS.
What is the protein family that this protein belongs to?
In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
Protein: OTCC_STRPY
Sequence: MTQVFQGRSFLAEKDFTRAELEYLIDFSAHLKDLKKRGVPHHYLEGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMFDGIEF
What are the official names of this protein?
Ornithine carbamoyltransferase, catabolic, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: NANK_HAEIN
Sequence: MRCLALDIGGTKIAAAIVKNGEIEQRQQIHTPRENVVEGMHQALGKLLADYEGQFDYVAVASTGIINNGILSALNPKNLGGLAEFPLKASIAKHTDKPIGLLNDAQAATYAEYQLQNSEQVSNFVFITVSTGVGGGIVLNQILQTGSRGIAGHIGHTLADPNGAICGCGRRGCVEAIASGRAIEAVSSQWEEPCDPKEVFERFRKNDEKATALVERSAKAIANLIADLVISLDIQKIAIGGSVGLAEGYLSLVEKYLQDFPSIYCCEIETAKFGQDAGLIGAAYWVKDVLLDKPEGTIYG
What is the function of this protein?
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
What are the official names of this protein?
N-acetylmannosamine kinase, ManNAc kinase, N-acetyl-D-mannosamine kinase.
What is the protein family that this protein belongs to?
Belongs to the ROK (NagC/XylR) family. NanK subfamily.