PharMolix/UniProtQA huggingface dataset:
Protein: MYPC2_CHICK
Sequence: MPEPSKAAPKKEAKKKEEKKEEKKEAPPPQEHKDEAPDDVHPPETPDPEGLFLSKPQNVMVESGRDVTVSARVAGAALPCAPAVKWFKGKWAELGDKSARCRLRHSVDDDKVHTFELTITKVAMGDRGDYRCEVTAKEQKDSCSFSIDVEAPRSSEGNVLQAFKRTGEGKDDTAGELDFSGLLKKREVQVEEKKKKKDEDDQFPPEIWELLKGVTKKSEYERIAFQYGITDLRGMLKRLKKVHVEPKKSEAFIRKLDPAYQVDKGNKIKLVVELSDPDLPLKWYKNGQLLKPSTKYVFENVGLKRILTIHKCSLADDAAYECRVNDEKCFTEVFVKEPPVTVVRGLEDQQVVVGDRVVLEAEVSEEGAQVMWLKDGVDVTRDDAFKYRFKKDGKKHFLIINEAELSDSAHYKIMTNGGESEAELSVEEKQLEVLQDMADLTVKASEQAVFKCEVSDEKVTGRWFRNGVEVKPSKRIHISHNGRFHKLVIDDVRPEDEGDYTFIPDGYALSLSAKLNFLEIKVEYVPKQEPPKIHLDCSGKAAENTIVVVAGNKVRLDVPISGEPAPTVTWKRGDQLFTATEGRVHIDSQADLSSFVIESAERSDEGRYCITVTNPVGEDSATLHVRVVDVPDPPQSVRVTSVGEDWAVLSWEAPPFDGGMPITGYLMERKKKGSMRWMKLNFEVFPDTTYESTKMIEGVFYEMRVFAVNAIGVSQPSLNTQPFMPIAPTSEPTHVVLEDVTDTTATIKWRPPERIGAGGVDGYLVEWCREGSNEWVAANTELVERCGLTARGLPTGERLLFRVISVNMAGKSPPATMAQPVTIREIVERPKIRLPRHLRQTYIRRVGEQVNLVIPFQGKPRPQVTWSREGGALPAEVQTRTSDVDSVFFIRSAARPLSGNYEMRVRIDNMEDCATLRLRVVERPGPPQAVRVMEVWGSNALLQWEPPKDDGNAEISGYTVQKADTRTMEWFTVLEHSRPTRCTVSELVMGNEYRFRVYSENVCGTSQEPATSHNTARIAKEGLTLKMVPYKERDLRAAPQFLTPLVDRSVVAGYTVTLNCAVRGHPKPKVTWLKNSVEIGADPKFLSRHGLGVLSLLIRRPGPFDGGTYGCRAVNEMGEATTECRLDVRVPQ
What is the function of this protein?
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands.  In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase.  It may modulate muscle contraction or may play a more structural role.
What are the official names of this protein?
Myosin-binding protein C, fast-type, Fast MyBP-C, C-protein, skeletal muscle fast isoform.
What is the protein family that this protein belongs to?
Belongs to the immunoglobulin superfamily. MyBP family.
Protein: AROA_GEOSM
Sequence: MENYTVQPAKSVRGEISVPGDKSISHRSIMFGSISSGVTKVTGFLRGEDALATLQAFRAMGVQIDDDGETVTIQGRGLHGLSEPTDVLDCGNSGTSMRLLTGLLAGQNFFSVLSGDKYLRARPMKRVVGPLALMGARISGRAGGEKAPLAIQGSKLIGIEYDSPVSSAQVKSAIMLAGLYAGGETVVREPHLSRDHSERMLRAFGAHVETFPGGVKVRGGAELTGRDIVVPGDISSAAFFLVAALIVPGSDLLIRGVGVNPTRTGIIDVLKGMGGDLELTNQRDESGEPVADIRVRHSKLTAMEICGEVVPRAIDEFPAICVAASLAQGTTVVRDAAELRVKETDRISAMADNLRRAGVNIVETPDGMQITGVASLKGCAADSFGDHRIAMSMMVAGLVAQGETSVSDVECIATSFPGFVNLLDGVVQR
What is the function of this protein?
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
What are the official names of this protein?
3-phosphoshikimate 1-carboxyvinyltransferase, 5-enolpyruvylshikimate-3-phosphate synthase, EPSP synthase, EPSPS.
What is the protein family that this protein belongs to?
Belongs to the EPSP synthase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RSMA_VIBVY
Sequence: MRNDVHMGHKARKRFGQNFLNDPYIIDGIVSAINPRPGQNLVEIGPGLGAITEPVGREVDKFTVIELDRDLAERLRTHPELADKLTIHEGDAMRFDFTQLVKPNNKLRIFGNLPYNISTPLMFHLFEFHKDIQDMHFMLQKEVVNRLAAGPGSKAYGRLTVMAQYYCKVVPVLEVPPTAFVPPPKVDSAVVRLVPYETLPHPANNLQWLERVCREGFNQRRKTVRNCYKSLMSEQVLEELGVNPGMRPENLTLQQFVAMANWLDANHK
What is the function of this protein?
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle.  May play a critical role in biogenesis of 30S subunits.
What are the official names of this protein?
Ribosomal RNA small subunit methyltransferase A, 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase, 16S rRNA dimethyladenosine transferase, 16S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: ISC10_YEAST
Sequence: MDVDERLHQDENQTHPFSQKKSSSFLIKEKAATKSKDLEHIRLRDLNFNHRKKLDDKKLAKQIPVKANFKKPNEIEARANLNSNELTDINLDYIPDSPSIEKISGPEDSIVVTPRNIIHLQSDSDIILEECEHNYDCSPFYRLFNYENRIEPDDYEAIINAIITDEIAGTYPVFERELEYQELKSLVRKRDYIMYYFLSRDYRGFFQLKEERTLFYRYPSIAYTSPLRYLDNGSETEQFTGDDDEELQSFDFENTSSVRTLDSNIWR
What is the function of this protein?
Indispensable for spore formation.
What are the official names of this protein?
Meiosis-specific protein ISC10.
Protein: GATA_LEPIC
Sequence: MNEILKKPYVELKDSLNSGKISSTELVSACINRIREVDGAVKAFLYLDEKKVLNSAEESDKRRKEGKPLSEFDGMPVAIKDNICIRDTITSCSSKILENYKSPFHATVVEKLLEKGFILFPRTNMDEFAMGSSTENSAFQTTRNPFDLERIPGGSSGGSAAAVAASMVPLALGSDTGGSVRQPASLCGLYGLKPTYGTVSRYGLVAYASSLDQIGPFSRELQGCIDLYSVISGKDVRDSTSIHRPKFSASDVQPQDFKGLKVGVIKMTPEIQSEVVKSYDKVLNQLKEKGATLVDIDFSKFGFAIPIYYIIATAECSSNLSRFDGIRFGSRKDKTGKLEDLFVDSRTEGFGPEVKRRILLGTFSLSAGYYDAYYGTAQKARALIRKEYESFFSKVDCILQPTSPTTAFKIGEKTKDPIQMYKADIWTTSVNLAGLPAMSVPMGADQKGLPIGLQITTPHFQEGKLFGIALALSTLEGMNIQFPESIK
What is the function of this protein?
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase.  The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
What are the official names of this protein?
Glutamyl-tRNA(Gln) amidotransferase subunit A, Glu-ADT subunit A.
What is the protein family that this protein belongs to?
Belongs to the amidase family. GatA subfamily.
Protein: TRPR_YERPE
Sequence: MTDEKQVSDSLNRQTAGNPYSAADPALSAEDNQHWLSFVALLQNAITQDLHLPLLQLMLTPDERTALGTRVRIIEELMRGELSQRELKSQLGAGIATITRGSNSLKTAPPQLKSWLEAQLLANKR
What is the function of this protein?
This protein is an aporepressor.  When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription.  The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity).
What are the official names of this protein?
Trp operon repressor.
What is the protein family that this protein belongs to?
Belongs to the TrpR family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: DRC8_HUMAN
Sequence: MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSPGIQSGPSSRPGSPRGAEQAGTPRPRLSLGISQATGSAARWRTRRTGKGLGYNSDEIRPRTLLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIRSLGCCPTEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEILLERKYRPIPEDVLLRAFEVLDSAKRGFLTKDELIKYMTEEDGVSLRRPG
What is the function of this protein?
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
What are the official names of this protein?
Dynein regulatory complex protein 8, EF-hand calcium-binding domain-containing protein 2.
What is the protein family that this protein belongs to?
Belongs to the DRC8 family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, flagellum axoneme.
Protein: COFH1_METAC
Sequence: MNSKIPEDLMERAYQGKCTKEDALQLLEVPPFELFRFADELRDLAVGDTVTYVVNRNINFTSRCVGTCGFCAFRTNNGKVLSIEEIMEKVRDAEKANATEVCIQGGLLPEVGLDFYQGIAEAIKAEFPEMHIHSFSPMEVYHASRISEIPVKEALRRLKRSGLDTMPGTAAEILSDRVRKIICPSKLKTAEWVEVVRQAHAAGIPTTATMMYGHVETREERIDHMLIIRDIQKETGGITEFVPLPFMPYNNPVGEKMIREGRYATPGLEDLKIYAVSRILFHGHVDNIQASWVKLGKKLAQFSLHCGTNDLGGTLMEESISRSAGACHGEMITVDELEWMIHGAGRIPKERTTLYRRVELASGNLRKISGCGAYE
What is the function of this protein?
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
What are the official names of this protein?
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase 1, FO synthase subunit 2 1.
What is the protein family that this protein belongs to?
Belongs to the radical SAM superfamily. CofH family.
Protein: ATPB_AERS4
Sequence: MSNGFIVQIIGAVVDIEFPQDAVPQVYDAVKVVSEGQGQGLVLEVQQQIGGGVVRCITMGSSDGLRRGLEVMNSGKSIQVPVGVSTLGRIMNVLGEPIDEKGPIGEEERWSIHRAAPSYEDQSNSNDLLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELIRNIAIEHSGYSVFAGVGERTREGNDFYHEMMESNVLDKVSLVYGQMNEPPGNRLRVALTGLTMAEKFRDEGRDVLFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTRTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRQIAALGIYPAVDPLDSTSRQLDPLVVGKEHYETARGVQTVLQRYKELKDIIAILGMDELSEEDKLTVARARKIERFLSQPFFVAEVFTGSPGKYVPLKETIRGFQGILKGEYDDLPEQAFYMVGSIDEVVEKSKKL
What is the function of this protein?
Produces ATP from ADP in the presence of a proton gradient across the membrane.  The catalytic sites are hosted primarily by the beta subunits.
What are the official names of this protein?
ATP synthase subunit beta, ATP synthase F1 sector subunit beta, F-ATPase subunit beta.
What is the protein family that this protein belongs to?
Belongs to the ATPase alpha/beta chains family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: TYPH_ECO5E
Sequence: MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAAIKLADKAPESTPTVYRRISE
What is the function of this protein?
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
What are the official names of this protein?
Thymidine phosphorylase, TdRPase.
What is the protein family that this protein belongs to?
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein: TTCA_METCA
Sequence: MPANAAAPLYAKERYEFNKLQKRLRRLTGQAIADYGMIQEGDRVMVCLSGGKDSFTLLDILLKLRINAPVNFDLVAVNLDQKQPGFPADVLPNYLSEQGIPFHIIEQDTYSVVKSIIPEGKTTCGLCSRLRRGLLYRYAADHGITKIALGHHRDDILETFFLNLFYGGTLKAMPPKLLSDDRRHIVIRPLAYCKEEDIARYARIRAFPIIPCNLCGSQENLQRQAMKAMLKDWEKRHPGRVETVFTALQNVAPSQLADSRLFDFAALDSLRNTAETTPEHGAGLDILSR
What is the function of this protein?
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32).  The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
What are the official names of this protein?
tRNA-cytidine(32) 2-sulfurtransferase, Two-thiocytidine biosynthesis protein A, tRNA 2-thiocytidine biosynthesis protein TtcA.
What is the protein family that this protein belongs to?
Belongs to the TtcA family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: AT131_CAEEL
Sequence: MGVDQLVETIIPYNLRSIATHLYVPPFTIITAIWTYVWLNIFGYEEYYELGMLGYAAIFVILALVLLFCHWMMPVRCFLMCSKQEDVRIASHVCVIPTQNNGWPELVKLMRTTRDKQTKLWFEFQRVHYTWDEESREFQTKTLDTAKPMVFFQKSHGFEVEEHVKDAKYLLGDNKTEMIVPQFLEMFIERATAPFFVFQVFCVGLWCLEDMWYYSLFTLFMLMTFEATLVKQQMKNMSEIRNMGNKTYMINVLRGKKWQKIKIEELVAGDIVSIGRGAEEECVPCDLLLLRGPCIVDESMLTGESVPQMKEPIEDVEKDKIFDIETDSRLHVIFGGTKIVQHTAPGKAAEGMVKSPDGNCICYVIRTGFNTSQGKLLRTIMFGVKKATANNLETFCFILFLLIFAIAAAAYLWIKGSVDETRSKYKLFLECTLILTSVIPPELPIELSLAVNSSLMALQKLGIFCTEPFRIPFAGKVDICCFDKTGTLTTDNLVVEGVALNNQKEGMIRNAEDLPHESLQVLASCHSLVRFEEDLVGDPLEKACLSWCGWNLTKGDAVMPPKTAAKGISGIKIFHRYHFSSAMKRMTVVAGYQSPGTSDTTFIVAVKGAPEVLRNMYADLPSDYDETYTRLTRQGSRVLAMGIRKLGETRVGELRDKKRENFENDLAFAGFVVISCPLKSDTKTMIREIMDSSHVVAMITGDNPLTACHVSKVLKFTKKSLPTLVLDEPADGVDWMWKSVDGTIELPLKPETKNKMERKAFFNSHEFCLTGSAFHHLVHNEHTFLRELILHVKVFARMAPKQKERIINELKSLGKVTLMCGDGTNDVGALKHANVGVALLTNPYDAEKAAEKEKEKKAKIEEARSLVRSGAQLPQRPGAPGAPPAANAARRDAPPGARARAPLPPMANAAQARLDNLMKELEEEEKAQVIKLGDASIAAPFTSKYTSIASICHVIKQGRCTLVTTLQMFKILALNALVSAYSLSALYLDGVKFSDTQATIQGLLLAACFLFISKSKPLKTLSRQRPMANIFNAYTLLTVTLQFIVHFSCLLYIVGLAHEANTEKAPVDLEAKFTPNILNTTVYIISMALQVCTFAVNYRGRPFMESLFENKAMLYSIMFSGGAVFTLASGQATDLMIQFELVVLPEALRNALLMCVTADLVICYIIDRGLNFLLGDMF
What is the function of this protein?
Mediates manganese transport into the endoplasmic reticulum.  The ATPase activity is required for cellular manganese homeostasis.
What are the official names of this protein?
Probable manganese-transporting ATPase catp-8, Cation transporting ATPase 8.
What is the protein family that this protein belongs to?
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
What are the subcellular locations of this protein?
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein: OBG_SALPA
Sequence: MKFVDEASILVVAGDGGNGCVSFRREKYIPKGGPDGGDGGDGGDVWMEADENLNTLIDYRFEKSFRAERGQNGASRDCTGKRGKDVTIKVPVGTRVIDQGTGETMGDMTKHGQRLLVAKGGWHGLGNTRFKSSVNRTPRQKTNGTPGDKRDLLLELMLLADVGMLGMPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVRMDSEKSFVVADIPGLIEGAAEGAGLGIRFLKHLERCRVLLHLIDIDPIDGSDPVENARIIIGELEKYSQDLAAKPRWLVFNKIDLMDKTEAEEKAKAIAEALGWEGKYYLISAASQLGVKDLCWDVMTFIIENPIAQAEEAKQPEKVEFMWDDYHRQQLAEVEEDADDDWDDDWDEDDEEGVEFIYKR
What is the function of this protein?
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate.  Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
What are the official names of this protein?
GTPase Obg, GTP-binding protein Obg.
What is the protein family that this protein belongs to?
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: PYRB_CLAM3
Sequence: MRHLLSTRDLSRDEAVHILDVAEDMADVGTREIKKTPALRGRTVVNLFFEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTAQTLQAMGADGVVVRHPSSGAPHTLAGSGWIDAGIVNAGDGTHEHPTQALLDAFTIRRRLHGTAARGKGLDGTRVVIVGDVLHSRVARSNAWLLTTLGAEVTLVAPPTLVPVGVGSWPVTVRYDLDAALAEGKPDAVMMLRIQAERMRAAFFPNPCEYARIWGLDDARLALLGPDTIVMHPGPMNRGLEISAAAADSERSTVREQVANGVSVRMAVLYLLLSGDGKADR
What are the official names of this protein?
Aspartate carbamoyltransferase, Aspartate transcarbamylase, ATCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Protein: CLCB_ECO8A
Sequence: MFRRLLIATVVGILAAFAVAGFRHAMLLLEWLFLNNDSGSLVNAATNLSPWRRLLTPALGGLAAGLLLMGWQKFTQQRPHAPTDYMEALQTDGQFDYAASLVKSLASLLVVTSGSAIGREGAMILLAALAASCFAQRFTPRQEWKLWIACGAAAGMAAAYRAPLAGSLFIAEVLFGTMMLASLGPVIISAVVALLVSNLINHSDALLYNVQLSVTVQARDYALIISTGVLAGLCGPLLLTLMNACHRGFVSLKLAPPWQLALGGLIVGLLSLFTPAVWGNGYSTVQSFLTAPPLLMIIAGIFLCKLCAVLASSGSGAPGGVFTPTLFIGLAIGMLYGRSLGLWFPDGEEITLLLGLTGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVIASVISRTLHRDSIYRQHTAQHS
What is the function of this protein?
Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
What are the official names of this protein?
Voltage-gated ClC-type chloride channel ClcB.
What is the protein family that this protein belongs to?
Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PTSN_KLEOX
Sequence: MINNDSALQLSNVLNQECTRSQVHCQSKKRALEIISELAAKQLGLSSQIVFEAILTREKMGSTGIGNGIAIPHGKLEEDTLRAVGVFVQLETPIAFDAIDNQPVDLLFALLVPADQTKTHLHTLSLVAKRLADKTICRRLRAAQSDEELYEIITEAGSNNEA
What is the function of this protein?
Seems to have a role in regulating nitrogen assimilation.
What are the official names of this protein?
Nitrogen regulatory protein, Enzyme IIA-NTR.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: EPHA1_HUMAN
Sequence: MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRMTLRLPSLSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFKD
What is the function of this protein?
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.  The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.  Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand.  Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC.  Also plays a role in angiogenesis and regulates cell proliferation.  May play a role in apoptosis.
What are the official names of this protein?
Ephrin type-A receptor 1, hEpha1, EPH tyrosine kinase, EPH tyrosine kinase 1, Erythropoietin-producing hepatoma receptor, Tyrosine-protein kinase receptor EPH.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
What are the subcellular locations of this protein?
Cell membrane; Single-pass type I membrane protein.
Protein: UPP_MYXXD
Sequence: MEFPNCTVVDHPLVKHKLTQMRRVETSTASFRALLQEISLLLAYEALRDLKVREEDIQTPMARTVAPVLDGKKLVLVAIMRAGQGILDGMLQLVPSARVGHIGLYRDPETLSPVEYYYRVPGQLADRDVVVCDPMLATGNSAVAALQRLKKSKPGSLRFVCLLACPEGLTNLREHHPDVHVYTAAIDERLDEHGYILPGLGDAGDRLFGTK
What is the function of this protein?
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
What are the official names of this protein?
Uracil phosphoribosyltransferase, UMP pyrophosphorylase, UPRTase.
What is the protein family that this protein belongs to?
Belongs to the UPRTase family.
Protein: YCIB_ECO5E
Sequence: MKQFLDFLPLVVFFAFYKIYDIYAATAALIVATAIVLIYSWVRFRKVEKMALITFVLVVVFGGLTLFFHNDEFIKWKVTVIYALFAGALLVSQWVMKKPLIQRMLGKELTLPQPVWSKLNLAWAVFFILCGLANIYIAFWLPQNIWVNFKVFGLTALTLIFTLLSGIYIYRHMPQEDKS
What is the function of this protein?
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
What are the official names of this protein?
Inner membrane-spanning protein YciB.
What is the protein family that this protein belongs to?
Belongs to the YciB family.
What are the subcellular locations of this protein?
Cell inner membrane; Multi-pass membrane protein.
Protein: PYRD_SYNP6
Sequence: MDFYRPLLRPLLLSQLNVDPEWLTRNALGFLATLARSRSPLAANLRSYLRQTYGFQDPRLAMSLWGLTFATPVGLAAGFDKDGIAAPLWSDLGFGFAELGTVTALAQPGNPRPRLFRIPQDLAAFNRMGFNNASAEALADTLRGYFPEGQRSIPIGINLGKSKLTPLSGAVSDYVSSFRSLRSLGDYFVVNVSSPNTPGLRSLQAVTELEPILAALQAENTEQRPLLLKIAPDLVDEEVVAIAHLAQRQQLAGIIATNTTIDKSLLSVEHLPGRREPLATEAGGISGAPLRSRSTEVIRLLHRTTQGQLPIIGVGGIFSAEDAWQKIVAGASLVQVYTGWVYEGPLLVKTIQQGLLERLDSAGLPNLAAAVGSAAIDS
What is the function of this protein?
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
What are the official names of this protein?
Dihydroorotate dehydrogenase (quinone), DHOdehase, DHOD, DHODase, Dihydroorotate oxidase.
What is the protein family that this protein belongs to?
Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
What are the subcellular locations of this protein?
Cell membrane; Peripheral membrane protein.
Protein: RL23_BURP0
Sequence: MSEIRKNDHRLMQVLLAPVISEKATLVADKNEQVVFEVAPDATKQEVKAAVELLFKVEVDSVNVLVQKGKQKRFGRSMGRRKDVKKAYVCLKPGQEINFEAEAK
What is the function of this protein?
One of the early assembly proteins it binds 23S rRNA.  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.  Forms the main docking site for trigger factor binding to the ribosome.
What are the official names of this protein?
50S ribosomal protein L23.
What is the protein family that this protein belongs to?
Belongs to the universal ribosomal protein uL23 family.
Protein: PRPK_HUMAN
Sequence: MAAARATTPADGEEPAPEAEALAAARERSSRFLSGLELVKQGAEARVFRGRFQGRAAVIKHRFPKGYRHPALEARLGRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSVTVRDYIQSTMETEKTPQGLSNLAKTIGQVLARMHDEDLIHGDLTTSNMLLKPPLEQLNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKARPVLKKLDEVRLRGRKRSMVG
What is the function of this protein?
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914).  The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914).  TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity).  Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
What are the official names of this protein?
EKC/KEOPS complex subunit TP53RK, Atypical serine/threonine protein kinase TP53RK, Nori-2, TP53-regulating kinase, p53-related protein kinase.
What is the protein family that this protein belongs to?
Belongs to the protein kinase superfamily. BUD32 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: SAHH_XANC8
Sequence: MNAVAKTVPHTDYKIADISLADWGRKELDIAEHEMPGLMSIRRKHAQTKPLKDVRITGSLHMTIQTAVLIETLKDIGANVRWASCNIFSTQDHAAAAIAATGTPVFAWKGETLEEYWDCTLDALTFTLPDGTLTGPELVVDDGGDVTLLIHKGYELENGSTWVDEPASSHEEGVIKALLKRVAVERPGYWARVVKDWKGVSEETTTGVHRLYQIAEAGKLLIPAINVNDSVTKSKFDNLYGCRESLADGLKRAMDVMLAGKVAVVCGYGDVGKGSAASLRAYGARVIVTEIDPICALQASMEGFEVNTIESTLGRGDIYVTTTGNKDIITVEHLQAMKDQAIVCNIGHFDNEIQVDALNALKGVEKINIKPQVDKYVFGNGNAIFLLADGRLVNLGCATGHPSFVMSNSFANQTLAQIDLWEKRDSYEKKVYILPKHLDEEVARLHLEKIGVKLTTLTKDQADYLGVDVAGPYKPDHYRY
What is the function of this protein?
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
What are the official names of this protein?
Adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, AdoHcyase.
What is the protein family that this protein belongs to?
Belongs to the adenosylhomocysteinase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: HIS2_VIBPA
Sequence: MSFKAAEVSSLSERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERLWTKGETSGNVLQLVNISLDCDNDTLLVRVNPIGPTCHTGTTTCWDGDAQEESQMVWLHQLEQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIYHLLVLLQDQGLSMNDVVNKLKERHK
What are the official names of this protein?
Histidine biosynthesis bifunctional protein HisIE.
What is the protein family that this protein belongs to?
In the C-terminal section; belongs to the PRA-PH family.
What are the subcellular locations of this protein?
Cytoplasm.