PharMolix/UniProtQA huggingface dataset:
Protein: OTCC_ENTFA
Sequence: MNSVFQGRSLLAEKDFSRAELEYLVDFSIHLKELKKKGIPHHYLEGKNIALLFEKTSTRTRSAFTTAAIDLGAHPEYLGANDIQLGKKESVEDTAIVLGSMFDGIEFRGFSQEVVEDLAKYSGVPVWNGLTDQWHPTQMIADFMTVKENFGRLEGITLVYVGDGRNNMANSLLVTGAILGVNVRICAPKELFPSDEVVNYAKEFAKESGAELMITDDVAKGVKGANVLYTDVWVSMGEEDKFEERVNLLKPYQINMAMLEKTENMDGDLIVLHCLPAFHDTKTQYGEMVAEKFGITEMEITDEVFRSKYGRQFEEAENRMHSIKAIMAATLGNLFIPRV
What is the function of this protein?
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
What are the official names of this protein?
Ornithine carbamoyltransferase, catabolic, OTCase.
What is the protein family that this protein belongs to?
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: TATA_PSEMY
Sequence: MGFGGISIWQLLIILLIVVMLFGTKRLKSLGSDLGDAIKGFRKSMDNGEAEKPAVEEPKGQTIDAQARKVEEPAKKD
What is the function of this protein?
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.  TatA could form the protein-conducting channel of the Tat system.
What are the official names of this protein?
Sec-independent protein translocase protein TatA.
What is the protein family that this protein belongs to?
Belongs to the TatA/E family.
What are the subcellular locations of this protein?
Cell inner membrane; Single-pass membrane protein.
Protein: LEU1_CAMHC
Sequence: MNKNKIIVFDTTLRDGEQSPGASMNTAEKVELAIQLEKLGVDVIEAGFAAASPGDFDAIERICGAVSKIRVCSLARAIEKDIKAAGESIKSAKFKRIHTFIATSPIHMEYKLKLSPDDVIKKAINSIKYAKTFCDDVEFSCEDAGRSEISFIKEIVEAAINAGATTINLPDTVGYRLPSEMSYMIGELVKFVGDRAVISSHCHDDLGMSVANTIACIKAGARQIECTINGLGERAGNTALEEVVMAIKTRSDVFAPLYTDINFKEIYHSSRLVATITGIEPQPNKAIVGKNAFAHESGIHQDGVLKHKETYEIMRAEDIGLEKNSIVLGKHSGSHAFRDKLVSLGYNLSEDELANVFEKFKILADAKKEIFDDDLRELMTDELVKIPCAFEIIALSSSECNKGHASAALTLKHNDEILKDSALGNGVVDAIFKTIDRISGIKGNLKDYQVRAVSQGKDAQAKVTVKVLFENSSTIIGHGLDTDTLMATAKAYIGALNSYISMKQ
What is the function of this protein?
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
What are the official names of this protein?
2-isopropylmalate synthase, Alpha-IPM synthase, Alpha-isopropylmalate synthase.
What is the protein family that this protein belongs to?
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Protein: TBG_SCHJP
Sequence: MGREIITLQAGQCGNQVGSQFWQQLCLEHGICPDGTLEDFATEGLDRKDVFFYQSDDTRYIPRAILLDLEPRVVNNILSDTYGSLYNPENIFVATDGGGAGNNWAHGYAHAEKIFEDIVDMIDREAEGSDSLEGFSLLHSIAGGTGSGLGSYLLERLNDRFPKKIVQTYSVFPNNRSVSDVVVQPYNSLLTLKRLTLNADAVVVLDNAALAHIAADRLHIQNPTFHQQNQLVSTVMSASTTTLRYPGYMNNDLVSIIASLIPTPRCHFLSTSYTPFTSQQVEDARTIRKTTVLDVMRRLLQPKNRMVSVNPGKQSCFISILNIIQGEADPNDVHKSLLRIRERKLATFIPWGPASIQVALSKKSPYIKTNHRVSGLMLANHTSIASLFKRTLDQYDRLRKRNAFLDQYRKESIFENSLDEFDNSREVVADLIREYEACEQPEYLSM
What is the function of this protein?
Tubulin is the major constituent of microtubules.  The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
What are the official names of this protein?
Tubulin gamma chain, Gamma-tubulin.
What is the protein family that this protein belongs to?
Belongs to the tubulin family.
What are the subcellular locations of this protein?
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body.
Protein: CYSI_ECOK1
Sequence: MSEKHPGPLVVEGKLTDAERMKLESNYLRGTIAEDLNDGLTGGFKGDNFLLIRFHGMYQQDDRDIRAERAEQKLEPRHAMLLRCRLPGGVITTKQWQAIDKFAGENTIYGSIRLTNRQTFQFHGILKKNVKPVHQMLHSVGLDALATANDMNRNVLCTSNPYESQLHAEAYEWAKKISEHLLPRTRAYAEIWLDQEKVATTDEEPILGQTYLPRKFKTTVVIPPQNDIDLHANDMNFVAIAENGKLVGFNLLVGGGLSIEHGNKKTYARTASEFGYLPLEHTLAVAEAVVTTQRDWGNRTDRKNAKTKYTLERVGVETFKAEVERRAGIKFEPIRPYEFTGRGDRIGWVKGIDDNWHLTLFIENGRILDYPGRPLKTGLLEIAKIHKGDFRITANQNLIIAGVPESEKAKIEKIAKESGLMNAVTPQRENSMACVSFPTCPLAMAEAERFLPSFIDNIDNLMAKHGVSDEHIVMRVTGCPNGCGRAMLAEVGLVGKAPGRYNLHLGGNRIGTRIPRMYKENITEPEILASLDELIGRWAKEREVGEGFGDFTVRAGIIRPVLDPARDLWD
What is the function of this protein?
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide.  This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
What are the official names of this protein?
Sulfite reductase [NADPH] hemoprotein beta-component, SiR-HP, SiRHP.
What is the protein family that this protein belongs to?
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
Protein: ABDA_SCHGR
Sequence: PNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARREREEQDRLKQQQEKKLEQQQQQQQQQQQQQQQQQQQQAPPQQPPQQHHTISHHLHDQHKLGLEKAPPGADLLKAVAKVPT
What is the function of this protein?
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
What are the official names of this protein?
Homeobox protein abdominal-A homolog.
What is the protein family that this protein belongs to?
Belongs to the Antp homeobox family.
What are the subcellular locations of this protein?
Nucleus.
Protein: GLKIN_CAMJE
Sequence: MAELKFKTKAQNLKNLQTKLKKAKVLPLVLTSLEELISNEDKVLQDIQTLKANRLIIRSSSLSEDSMKNSNAGAFLSLANIKADSKDELLKALYEVANSMPSKSDEILVQPMLENITLCGVGFSVDKDNFSPYFCLQYDENGSNSSITDGSSKSAKTYYHYRNYLEFKDIRLQKIIELIKELEVLYDCHFLDVEFAFAIQDDKEELFCLQVRPLVMHEKNNLFHSLPKEALYRFYKRFESLKESRSRVLGDKAIFGVMPDWNPAEIIGLRPKRLAFSLYKEIITDNIWAYQRDNYGYRDLRSHPLIHSFLGIPYVDVRLSFNSFIPKKLDENIAQKLVNFYLDKLNKNHELHDKIEFNIVYSCYDFNSSKKLEELLNHGFNENEIKRLEFSLLELTNKIINPRSGFYLKDIQKAYKLKERYDGIINSNFSLIDKIYWLIEECKRYGTLPFAGVARAAFVAMQLLNSLVEIDFITKEEKDDFLNSLNTVSKNLSKQTNHLNFHNKDQFLKDFGHLRAGTYNILSPRYDEDFELYFDADQKDSKVYLQDKAFVFSKEKTRALNALLKEHGLEINACEFFDFLKQAIEGRELVKFEFTRLLSKAIVYIEELGKYYDIEKEDLAHLDIKSILNLYSSLYSINPKEQFIEEINRNKKEYELTQAIKLPSLLCNADEIFSFYNHSIIPNFITQKSITAFTAKENDKDLEGKIVLIYAADPGYDYLFTKNIAGLITCYGGANSHMAIRASELGMPAVIGVGEENFEKYLKAKKINIECESEQIFCL
What is the function of this protein?
Involved in the biosynthesis of the O-methyl phosphoramidate (MeOPN) group found on the capsular polysaccharide (CPS) of C. jejuni (PubMed:17675288).  Catalyzes the ATP-dependent phosphorylation of the amide nitrogen of L-glutamine to form L-glutamine phosphate, the first committed step in MeOPN biosynthesis (PubMed:28650156, PubMed:30142271).  Catalyzes also the phosphorylation of D-glutamine, gamma-L-glutamyl hydroxamate, gamma-L-glutamyl-hydrazide and beta-L-aspartyl hydroxamate (PubMed:30142271).  Does not phosphorylate L-glutamate or L-asparagine (PubMed:28650156, PubMed:30142271).  Does not act on L-glutamine derivatives with removed alpha-amino or alpha-carboxy groups (PubMed:30142271).
What are the official names of this protein?
L-glutamine kinase.
Protein: WTF15_SCHKA
Sequence: MSNNYTSLSSSLDEEMGLKAGHEIDLEGSPPSEHNSEEKSTLPSNSDILTSANPVSQASETPDHSIESNTGSTQSPTSHSLLLKFSFCIVYYFYFAIVVLGCVLPFEHTHTFLIAFLVIFGIISVILFSGSIYYYETWTKTVKHFLKKVISPFKKEYIVCAFLKTFVFYGLLKTIEHFLVLLSGDKWGWKCSTLSSILTPVSCISFCLNESVQLRSCSTHLFINTVAWIKSLGGGKNAFENNYNQLNETSPEDLV
What is the function of this protein?
May act in meiotic drive.
What are the official names of this protein?
Wtf element wtf15.
What is the protein family that this protein belongs to?
Belongs to the WTF family.
What are the subcellular locations of this protein?
Spore membrane; Multi-pass membrane protein.
Protein: UBIE_SALTI
Sequence: MVEDSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRMVGETGKVILADINDSMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTEKEKALRSMFRVLKPGGRLLVLEFSKPIIEPLSKAYDAYSFHILPRIGSMVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVDYYNLTAGVVALHRGYKF
What is the function of this protein?
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
What are the official names of this protein?
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE, 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase.
What is the protein family that this protein belongs to?
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
Protein: ANKR7_MACFA
Sequence: MNKLFSFWKRKNETRSRTSSDPSIGQGYKLREKDLKKLHRAASVGDLKKLKEYLQLKKYDVNMQDKKYRTPLHLACANGHRDVVLFLIEQQCKINIRDSENKSPLIKAVQCQNEDCATILLNCGADPNLRDVRYNTALHYAVCGQSFSLVEQLLDYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILAVSGEPTRLVKLLLQQGVELSCRDICGFTAEEYAYFNGFTVYPQFTASHGRKKHVK
What are the official names of this protein?
Ankyrin repeat domain-containing protein 7.
Protein: Y063_BORBU
Sequence: MLILPKTTIKALLLVIFGSLIVSFAIFFMVLENNEITVVPNLYSLAIEDAVLELQRKELIPHIEFKFSSSALDKGKVIDQGPKPGTVLRHGNKVIIFISKGAIINRVDSFIGKNIDDVIINLKANSFDNSKLLYHIVQPLEVESELPKGIIISQNPSPGSQISSLTDLQFLISKGKDHLDKHVKNYVGIYYKDAIASLLSDSINFDIDLANIGDFGNIISQSIPPGTKINESDKILITIAKPKVDNKIVFGILTYKLRQHPSYVDISVRLKGVDGKNSLIYSFKSKGGLIKLPYEVNKGSMIELYIYDKLINQTVIN
What are the official names of this protein?
Uncharacterized protein BB_0063.
What are the subcellular locations of this protein?
Membrane; Single-pass membrane protein.
Protein: BKRF4_EBVB9
Sequence: MAMFLKSRGVRSCRDRRLLSDEEEETSQSSSYTLGSQASQSIQEEDVSDTDESDYSDEDEEIDLEEEYPSDEDPSEGSDSDPSWHPSDSDESDYSESDEDEATPGSQASRSSRVSPSTQQSSGLTPTPSFSRPRTRAPPRPPAPAPVRGRASAPPRPPAPVQQSTKDKGPHRPTRPVLRGPAPRRPPPPSSPNTYNKHMMETTPPIKGNNNYNWPWL
What is the function of this protein?
Overcomes the host DNA damage response (DDR) triggered by double-stranded DNA breaks by binding to host histones H2A/H2B, H3/H4 and to cellular chromatin (PubMed:35870648, PubMed:36067323).  Can associate with the partially unfolded nucleosomes, promoting the nucleosome disassembly (PubMed:36067323).  Interferes with histone ubiquitination and recruitment of repair proteins (PubMed:29743367).
What are the official names of this protein?
Tegument protein BKRF4.
What is the protein family that this protein belongs to?
Belongs to the lymphocryptovirus BKRF4 family.
What are the subcellular locations of this protein?
Virion tegument.
Protein: MDTA_SALPC
Sequence: MKGSNTFRWAIAIGVVVAAAAFWFWHSRSESPTAAPGVAAQAPHTAAAGRRGMRDGPLAPVQAATATTQAVPRYLSGLGTVTAANTVTVRSRVDGQLIALHFQEGQQVNAGDLLAQIDPSQFKVALAQAQGQLAKDNATLANARRDLARYQQLAKTNLVSRQELDAQQALVNETQGTIKADEANVASAQLQLDWSRITAPVSGRVGLKQVDVGNQISSSDTAGIVVITQTHPIDLIFTLPESDIATVVQAQKAGKTLVVEAWDRTNSHKLSEGVLLSLDNQIDPTTGTIKIKARFTNQDDTLFPNQFVNARMLVDTEQNAVVVPAAAVQMGNEGHFVWVLNDENNVSKKRVKIGIQDNRNVVISAGLSAGDRVVTDGIDRLTEGAKVEVVEPQTTMADEKSPSRHEGQKGARA
What are the official names of this protein?
Multidrug resistance protein MdtA, Multidrug transporter MdtA.
What is the protein family that this protein belongs to?
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
What are the subcellular locations of this protein?
Cell inner membrane; Peripheral membrane protein.
Protein: LECM_THRJA
Sequence: MGRFIFATLGLLLVAFSINGAKGCCCPHDWLTLKGFCYKVFNEHKTWNDAEMFCRKYKPGCHLASIHSGEESTDLAEYVSDYLKSGGNVWIGLNDPQKKRSWQWTDRSQNNFYPWKQGEPNNRANNENCVELWSPLGYKNWNDESCASTRAYLCKCRF
What is the function of this protein?
Mannose-binding lectin which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids.  May be a calcium-dependent lectin (By similarity).
What are the official names of this protein?
C-type lectin lectoxin-Thr1, CTL.
What is the protein family that this protein belongs to?
Belongs to the true venom lectin family.
What are the subcellular locations of this protein?
Secreted.
Protein: SC52_SHEEP
Sequence: METQRASLSLGRRSLWLLLLGLVLASASAQALSYREAVLRAVDQLNEKSSEANLYRLLELDPPPKQDDENSNIPKPVSFRVKETVCPRTSQQPAEQCDFKENGLLKECVGTVTLDQVGNNFDITCAEPQSVRGLRRLGRKIAHGVKKYGPTVLRIIRIAG
What is the function of this protein?
Broad spectrum bactericidal agent.
What are the official names of this protein?
Cathelin-related peptide SC5, Antibacterial peptide SMAP-29, Myeloid antibacterial peptide MAP-29.
What is the protein family that this protein belongs to?
Belongs to the cathelicidin family.
What are the subcellular locations of this protein?
Secreted.
Protein: NTPPA_PSEPF
Sequence: MKKLYLASGSPRRRELLTQIGIPFTAISADIDETPLANESPLAYVERLARGKAEAGRRIVTSEPPFCVLGADTAVVLDGKILGKPVDEADACAMLMMLSGKEHEVLTAIAVLDGERCESRVVRSLVRFRSISREEAAAYWASGEPRDKAGGYGIQGLGAVFVAGLNGSYSAVVGLPVCESAELLGHFGIPCWQTLNAQ
What is the function of this protein?
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP.  May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
What are the official names of this protein?
dTTP/UTP pyrophosphatase, dTTPase/UTPase, Nucleoside triphosphate pyrophosphatase, Nucleotide pyrophosphatase, Nucleotide PPase.
What is the protein family that this protein belongs to?
Belongs to the Maf family. YhdE subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: REPJ_ECOLX
Sequence: MATHKPINILEAFAAAPPPLDYVLPNMVAGTVGALVSPGGAGKSMLALQLAAQIAGGPDLLEVGELPTGPVIYLPAEDPPTAIHHRLHALGAHLSAEERQAVADGLLIQPLIGSLPNIMAPEWFDGLKRAAEGRRLMVLDTLRRFHIEEENASGPMAQVIGRMEAIAADTGCSIVFLHHASKGAAMMGAGDQQQASRGSSVLVDNIRWQSYLSSMTSAEAEEWGVDDDQRRFFVRFGVSKANYGAPFADRWFRRHDGGVLKPAVLERQRKSKGVPRGEA
What is the function of this protein?
This protein is involved in regulating the plasmid copy-number.  Increasing the level of this protein results in a higher plasmid copy-number.
What are the official names of this protein?
Regulatory protein RepA.
Protein: LOT5_DEBHA
Sequence: MKPNPKLIFEQPNIENTIPLSVYQASSPEKFSIEDDDKLVMHAGGSGYKISILRNDPTQEVKVHEDFQSMENSSVSLFVLNTCVIIWLDEIQKGLELPYQSISLSALQSNNDHQALYLQVLSNDYISSIPTEPTEYTSTVELIITKEKDIPESMVNRLFESMVSDIHGLYNGLSTCSAFHYDSDSDEENGDNTNGFYGMDFQDSDTNAPALEIPSSWIDDEGHDHDIAIKNIGDADDLELDEEELQRVRDESGTPVAGMNVDVGYASIVGSIRKRGEDDMGEFNKSRKLI
What are the official names of this protein?
Protein LOT5.
What is the protein family that this protein belongs to?
Belongs to the LOT5 family.
What are the subcellular locations of this protein?
Cytoplasm. Nucleus.
Protein: RL19_BURL3
Sequence: MNLIAKLEQEEIERALAGKTIPEFAPGDTVIVNVNVVEGNRKRVQAYEGVVIAIRSRGLNSNFIVRKISSGEGVERTFQTYSPLLASIVVKRRGDVRRAKLYYLRERSGKSARIKEKLVSKDRTAAASQE
What is the function of this protein?
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
What are the official names of this protein?
50S ribosomal protein L19.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL19 family.
Protein: LV1D_MOUSE
Sequence: MAWISLILSLLALSSGAISQAVVTQESALTTSPGETVTLTCRSTTGAVTTGNYANWVQEKPDHLFTGLIGGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLG
What are the official names of this protein?
Ig lambda-1 chain V region H2020.
Protein: NU4LM_CHEME
Sequence: MLSISMNMTLAFTTALLGMLMFRSHLMSSLLCLEGMMLSMFILSTLLILNMQYTITFMMPILLLVFAACEAAIGLALLVTVSNTYGLDYIQNLNLLQC
What is the function of this protein?
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
What are the official names of this protein?
NADH-ubiquinone oxidoreductase chain 4L, NADH dehydrogenase subunit 4L.
What is the protein family that this protein belongs to?
Belongs to the complex I subunit 4L family.
What are the subcellular locations of this protein?
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein: VIF_HV1H2
Sequence: MENRWQVMIVWQVDRMRIRTWKSLVKHHMYVSGKARGWFYRHHYESPHPRISSEVHIPLGDARLVITTYWGLHTGERDWHLGQGVSIEWRKKRYSTQVDPELADQLIHLYYFDCFSDSAIRKALLGHIVSPRCEYQAGHNKVGSLQYLALAALITPKKIKPPLPSVTKLTEDRWNKPQKTKGHRGSHTMNGH
What is the function of this protein?
Counteracts the innate antiviral activity of host APOBEC3F and APOBEC3G.  Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions.  Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F.  In turn, they are directed to the 26S proteasome for degradation.  Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism.  May interact directly with APOBEC3G mRNA in order to inhibit its translation.  Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core.  Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells.
What are the official names of this protein?
Virion infectivity factor, Vif, SOR protein.
What is the protein family that this protein belongs to?
Belongs to the primate lentivirus group Vif protein family.
What are the subcellular locations of this protein?
Host cytoplasm. Host cell membrane; Peripheral membrane protein; Cytoplasmic side. Virion. Note=In the cytoplasm, seems to colocalize with intermediate filament vimentin. A fraction is associated with the cytoplasmic side of cellular membranes, presumably via the interaction with Pr55Gag precursor. Incorporated in virions at a ratio of approximately 7 to 20 molecules per virion.
Protein: TYSY_ACTSZ
Sequence: MRQYLDLCQRIVDEGVWLENQRTGKRCLTVINADLTYNAAANEFPIITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGAKTWDANANENQAWLNNPVRKGVDDMGRVYGVQGRAWRKPNGETVDQLRKIVDDLSRGIDDRGEILTFLNPGEFDLGCLRPCMYSHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKPGQAYHKIVNAHIYEDQLDLMRDVQLKRRPFPSPRLEINPDIKTLEDLETWVTLDDFNVVGYECHEPIKYPFSV
What is the function of this protein?
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product.  This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
What are the official names of this protein?
Thymidylate synthase, TS, TSase.
What is the protein family that this protein belongs to?
Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
What are the subcellular locations of this protein?
Cytoplasm.
Protein: RL36_PARP8
Sequence: MKVMASVKRICRNCKIIKRKGVVRVICSSDPRHKQRQG
What are the official names of this protein?
50S ribosomal protein L36.
What is the protein family that this protein belongs to?
Belongs to the bacterial ribosomal protein bL36 family.
Protein: THIC_CUPNH
Sequence: MARTAPAASFESLESDLDQKFAYPASSKTYLTGSRPDIRVPLRTILQTSTRTDKGEMQNPPIPVYDTSGPYSDPDVHIDLKAGLPAVRAKWIEERGDTEVLPGLSSEYGRDRANDPATAHLRFAQLTNPRRAKAGANVSQMHYARKGIITPEMEYVALRESLNLQALYDKPDYKALLRQHPGNALGAGLPLRPEDITPEFVRQEIASGRAIIPANINHTELEPMAIGRNFRVKINGNLGNSAVTSSLAEEVEKMVWSIRWGADTIMDLSTGKHIHETREWILRNSPVPIGTVPIYQALDKTGGIAEDLTWEMFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTADRVTGIVSRGGSIMAKWCLAHHKENFLYTHFDEICEIMKAYDVSFSLGDGLRPGCIADSNDDAQFGELRTLGELTAKAWKHDVQVMIEGPGHVPLQRIQANMDEELKHCYEAPFYTLGPLVTDIAPGYDHITSGIGAANIGWMGTAMLCYVTPKEHLGLPDKEDVREGIITYKIAAHAADLAKGWPGAQLRDNALSKARFEFRWEDQFNLGLDPERARSYHDATLPAEGAKIAHFCSMCGPKFCSMKITQEVRDYAASLPKEAQQGMEEKSIEFLKKGSKIYS
What is the function of this protein?
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
What are the official names of this protein?
Phosphomethylpyrimidine synthase, Hydroxymethylpyrimidine phosphate synthase, HMP-P synthase, HMP-phosphate synthase, HMPP synthase, Thiamine biosynthesis protein ThiC.
What is the protein family that this protein belongs to?
Belongs to the ThiC family.
Protein: OGDHL_XENLA
Sequence: MSHLRSVAAKLKPYCTGLLVKHNSILRTLPPRCYVYSSGAKEPFLSGTNSSYVEEMYYAWLENPKSVHKSWDAFFRSADNGTPQCEIQGVPSLADIESKLPSLSSQGLATAPAKAEKIVEEHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTLDKLGFYGLHEGDLDKVFRLPTTTYIGGTDSTLSLREIIRRLENSYCQHIGLEFMFINDVEQCQWIRQKFETPGIMKFINEEKRTLLARLIRSTRFEDFLARKWSSEKRFGLEGCEVMIPALKAIIDKSSEMGLEYVILGMPHRGRLNVLANVIRKDLDQIFCQFDPKLEASDEGSGDVKYHLGMYHERINRATNKKITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDTEGNKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTIHIVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVMYVCSVAAEWRNTFNKDVVVDLVCYRRSGHNEMDEPMFTQPLMYKQIHKQVPVLKKYADKMIAEGTVTLQEFEEEIAKYDRICEEAYARSKDKKILNIKHWLDSPWPGFFTLDGEPKSMTCPPTGIPEDMLSHIGAIASSVPLKDFKIHGGLSRILKSRLEMTNSRTVDWALAEYMTFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRWTCVPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFYNTAQCIIDQFISSGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPEFTQDFDVSQLFDCNWIVVNCSNPASYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDDMKTGTNFQRVIPENGAASHSPQEVKRVIFCTGKVYYELVKERHRKGLDSQVAITRLEQISPFPFDLVKQEAEKYATSELVWCQEEHKNMGYYDYVKARFLTILNHARPVWYVGRDPAAAPATGNKNTHHVELRRFLDIAFDLEYFEGKPF
What is the function of this protein?
2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle.  The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH.  The OGDHC complex is mainly active in the mitochondrion (By similarity).  Involved in the inhibition of cell proliferation and in apoptosis (By similarity).
What are the official names of this protein?
2-oxoglutarate dehydrogenase-like, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1-like, OGDC-E1-like, Alpha-ketoglutarate dehydrogenase-like.
What is the protein family that this protein belongs to?
Belongs to the alpha-ketoglutarate dehydrogenase family.
What are the subcellular locations of this protein?
Mitochondrion matrix.
Protein: CUL5_RABIT
Sequence: MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTRKLYIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA
What is the function of this protein?
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.  As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.  The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component.  ECS(SOCS1) seems to direct ubiquitination of JAK2.  ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine.  As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A.  May form a cell surface vasopressin receptor.
What are the official names of this protein?
Cullin-5, CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1.
What is the protein family that this protein belongs to?
Belongs to the cullin family.